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<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUF0</accession>
    <name>A0A0B1NUF0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005917">
        <property type="protein sequence ID" value="KHJ29992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUF0"/>
    <dbReference type="STRING" id="52586.A0A0B1NUF0"/>
    <dbReference type="HOGENOM" id="CLU_2051397_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ29992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="120" mass="13793" checksum="01AEC9442A53C71C" modified="2015-03-04" version="1">MVEEVVKDGLRQYVKTQGKSWSEDLEQDKRLKPDLLLSTHQEEKSETAEENGGKNNLDGINEVDFQITLDHSSVETIMECLRPWWVAQPYVRPLPKEALAKGSWALSKRELKEAAQKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVY7</accession>
    <name>A0A0B1NVY7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tuberous sclerosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005010">
        <property type="protein sequence ID" value="KHJ30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1NVY7"/>
    <dbReference type="HOGENOM" id="CLU_004261_0_0_1"/>
    <dbReference type="OMA" id="IMFLPHI"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="887" mass="103340" checksum="9A81F7216998569C" modified="2015-03-04" version="1">MSSGSLKDLTKAISKEIPKLSLPLPTSILDVISAYLERHSPDDDSDVIYLQDELLILYKNIVEQYPTSLAAFLAILSRLKQFFPQTGRLLQWWNELLIPILNNLSIQPKLADEARDILLDILVYDEDDSEGKRLENLKASSFSVAEILLSSWLLKIKQADDELNDLAGYVAGHIQLILIEYGKKRPKDFLIVLNKYFARPESRIFSLSLLCSFLRHPPPHLHQMLLTPLFVNLLKCLQFDTSTRAVSLAMTALAMFLPHIPCTLSQYLPTLFNIYTRMLFWDRVREVENFSNSDIKEISTDAHANDWTKLPHLLDSKDEYIPELLQYFTFLYGLYPINFINYIYKPQEYLGHTFSLETELDIHPTEVKQRSEPFRQVHILHPNFFRYTIESELCDDSRWIKSDAADVVAECFALYIPSEDFNEKSSRPNTIKYDPDIIGLTLHDDDSSLIQTGFYEFQAPDQFTNPPSSQKRTSLSSLSISSSQVDPGNKFSESSSAPEKSSLDAYLGPSQYQRTVRKLSPTIFQRHNVLRSMKNTSVASFASSNQHYSQLDCFHTSLKQDDIAPSPFLYTKPAEPLTSDKRIAYLYREIQLLRNFLNFERYLKQQHLSHIGKLRRKYIREALNEAETQNILTSNRSLQLKLQEAKRLITQLRKEGEKSKIHWRKWEAELSCKIRFLREEQRKWMTERQEMGRELDTLKTNETVMRHIILKLEADELKEKQKAAHVQSNLEELERLRSEIEELEMRVRIYEVNEQSIKEAKEDDVTKARLVMLEELLKSRDQELLDARKIFDQEVSYIRKQVQINKVSPKIDNPNFQEMIDGALAISRSRINELQKKYNHLLTRYSNLQDQYYGFHNDNDDSLNIDEILLSGNDRDRAEAPLCHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWH7</accession>
    <name>A0A0B1NWH7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004582">
        <property type="protein sequence ID" value="KHJ30283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWH7"/>
    <dbReference type="HOGENOM" id="CLU_1327257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="207" mass="23155" checksum="3D87EF31CD542BC3" modified="2015-03-04" version="1">MTDQSEGAYYREADKSQNQEHGYAFEKASAASSVLSNPAESSSRPRKQKTSVGKPEKNGMKAVKDLREIVGREGLGPLNYRALAEKTNVPLNLLEFFQASPDAAKEFRKISQRFNIRKGPRPGNKAKTKAKIPADSASVKVDRKNTDSRETLTQSDFNIDPKTIFSRVNPEHKAFHFVAVLRGRYNEKSHWKKVTLSPGISQAYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWP2</accession>
    <name>A0A0B1NWP2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004375">
        <property type="protein sequence ID" value="KHJ30373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWP2"/>
    <dbReference type="HOGENOM" id="CLU_041336_0_0_1"/>
    <dbReference type="OMA" id="CDIRIDV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="42527" checksum="8AB29EF05DD6FA34" modified="2015-03-04" version="1">MISPSLIGKIKPVRSGFALSPCSTEARDTIWNAGNGLFLTGAKLEPATNWVSVLIPTVPSKIRKQHGEVEINSSLLSDEIKRVCSVRPTHVKLYVHNKSEAPHRTWMAFFVKAPHSGFRVFDESGIARAFKKQQPIEFCKRCNGHHPAKNCSRAPSCSNCGSTNHAADSCMAVTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQLKIYRQAGDREYQAVLMARAAEEKAANSTCIEIDPSNSQETEASDNIQVTHVESQTGDIALSRACDIRIDVLLVQEPWWSNCTKTHPCFDLYLPFGGDNIRPRAVTYVRKDPNRLTSSQKYPFVPTGDYCWVEVNNITFLNIYKAPNDPNAVRPLLEWSPTSKTITIGDFNSVYWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWP5</accession>
    <name>A0A0B1NWP5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004365">
        <property type="protein sequence ID" value="KHJ30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWP5"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10975" checksum="1A846BA09EF3219D" modified="2015-03-04" version="1">MAATKCRNCSGPHRADSRRCLARPTRSDAPTKEQLKTYRQMGEREYNAVQRAKVAEEKAASIDRTEIDLTDSQASEVSMTIDNSQATPVEDMTAVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXB8</accession>
    <name>A0A0B1NXB8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01003313">
        <property type="protein sequence ID" value="KHJ31037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXB8"/>
    <dbReference type="STRING" id="52586.A0A0B1NXB8"/>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="OMA" id="YRYRHIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="79"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="380"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="718" mass="82802" checksum="E4F684AD3BE904C9" modified="2015-03-04" version="1">MTDLSRWRLTSTNLGVHRWIYLKEEELAESAEQSDAERYLLGLDLNLGGEKEEEKEKIDLSKPPRSYEDSARAGWKFYSRLQLPQGHWACEYGGPSFLLPGIIFSMYISDTPVPDEWKLEIFRFLSNHVNNDGGWGLHLYGKSTVFGTCLYYVALRLLGYEKEVPLLSEARKCLLSLGGAIGIPQWGKIWLSCLNLYGWDGVNCIPVDLWILPTWLPIHPSRWWVQCRVVYLPTSYLWSNRCTKPLNSLLKQIRDEIYCEPFERINFAKHGNNVAPSDRIRSVTPILRFFFFILTIWCNYLRPNWLLRYANQKVSKLMKMEEQNTDHECLAPVNKAFHVAVTWFEESESERLQRHRENIATYMWMGPAGMTCNGTNGVQVWDTEFSVLAATTAGFAFDADLNRSLFKAHSFLERSQFRDNLDDEFRQPRKGGWPFSTKTNGYIVSDCAAEGLKSTLVLQNDCSFPELIDDSRLKECVDTLLLMQNSNGGFASYEKNRGSEYLELLNPAEVFDRIMVEYSYPECTTAVLTALSKFKKHYPGYRKSEIQRAISEAHRYIIESQREDGSWYGSWAICFTYATFFALQSLEAVGEQYKNSPRVKLACEFLLSKQKDDGGWGEHYTSCEEKRYIDHENSQVVNTSWATLALMHAGYPDPTPIQRGLDLIQNRQKANGEWLQEAVEGVFNQTCMIGYPNYKFSFTIMALGAYKTLYLPKLKEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXH6</accession>
    <name>A0A0B1NXH6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003257">
        <property type="protein sequence ID" value="KHJ31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXH6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXH6"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39114" checksum="32BF7D01E59E4C49" modified="2015-03-04" version="1">MHFSKIIATVARKGQKKARINLSTTARLAPLGKTSHCSNNKEKSENPTSSTKAISDNRLFLRLPQDQEWCKLSPAGVREVMVKKLHISPSIISRIKPVHSGFALSPSNSEVREKILKAENGLFLSGAKLEPATNCVSVLVPTVTAFIQMEEGQVEVSKSMLSDEIERVCSVRPAYIKLFGQNNSKAPHRTWMAYFCKAPRSGFRVFDESGIMRPYKKQQSIEFCKRCNGHHPSKNCSRAPSCGNCGSKNHNVDICKAATKCRNCGGPHRADSRRCLARPTRSGAPSKEQLKVYRQAGEREYQAVLRVRAAEEKAMITEKIIIDSTNSNLPEADSSSDIIQVTPDEVSTGVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYI9</accession>
    <name>A0A0B1NYI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002879">
        <property type="protein sequence ID" value="KHJ31447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYI9"/>
    <dbReference type="STRING" id="52586.A0A0B1NYI9"/>
    <dbReference type="HOGENOM" id="CLU_1662113_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="159" mass="17860" checksum="9FDF7F3D062900EC" modified="2015-03-04" version="1">MSSGRLLGFVNRSGRYESPYNSDRNAAQALKFSQKPTAITSGVGVAAQKELGSGYIDQNNNRALSPLPILQKDLEAQDEHQLQNNYNENAYPQSIVFDSIVDSDFDHTRTDSLGEPETNFQPDDKDNQINFMLGRKYVDSNFEQSGVDRRMEPYSNFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYL1</accession>
    <name>A0A0B1NYL1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003291">
        <property type="protein sequence ID" value="KHJ31068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYL1"/>
    <dbReference type="STRING" id="52586.A0A0B1NYL1"/>
    <dbReference type="HOGENOM" id="CLU_891967_0_0_1"/>
    <dbReference type="OMA" id="GISREHN"/>
    <dbReference type="OrthoDB" id="3598256at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="35088" checksum="5BCB457F9B338FEF" modified="2015-03-04" version="1">MRPEFNTGTQENNVDYNDFTNIYPSTKNVKRKVNGRLRTIVGREDKGPLDYKKLLDNTMVTMSMMELYQASPDFAKCSRKYSTRINEKRVKKGKIATSVAEEEEEILLAEATSSSAGMRNFSDPTQSRFEESYPMNCNSVTSNQFPQVNLISNVTLKTTARKDRAFRVPGEVLLSRDGRPGRIYLNNSMVCADQGSDLVLISPQLVRILRLEKNTLSSPQNQVITMGTADGASHRITEWVSFVFVSGGITRHVHAFVRPDKGMTNDLFLLLGLPWLHSVKAVINIVKSQIRIGDKRLGEKRTTLQGPTFECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ18</accession>
    <name>A0A0B1NZ18_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002695">
        <property type="protein sequence ID" value="KHJ31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ18"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ18"/>
    <dbReference type="HOGENOM" id="CLU_020802_0_0_1"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="40734" checksum="FDD11C9683706423" modified="2015-03-04" version="1">MLVITCISILAIDFHIFPRRFAKVETWGTSLMDVGVGSFVFSSGIVAARPLLLDQGKPSRNESLPRDELLKAGRSSLPLLMLGLIRLWSVKELDYAEHTSEYGVHWNFFFTLGFLPPFVSLFKSAFNYIPSYAILAVILGTVYQVCLDFTNLKAYILTAPRDNLLSMNREGVFSFVGYLAIFLIGQETGLYVLPRRLLQKRFSAWQQRKRLLLYLGGASLAWILLFKTTTNRNYGLNMTVSRRLANLPYILWIAAFNTSQLTAFCLIETFFFPDVWGVSEHITEIEEEVIYHYATSGILEAYNRNGLAVFLLANVLTGAVNLSVSTLYCSNLKAMVILVLYTACISGTATALNWWNISIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ94</accession>
    <name>A0A0B1NZ94_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc knuckle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005645">
        <property type="protein sequence ID" value="KHJ30011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ94"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ94"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_7_1"/>
    <dbReference type="OMA" id="ERRRCVY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="457"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="579" mass="65918" checksum="BCFF9574B428924F" modified="2015-03-04" version="1">MLNPKKHKVVALQEPSLNPRTLDTYCPRGYILCMEPTLETKVAFLISRDIGVANWTYKWYSNLVAEIKLSFHESLLRIVNVYSPTTSGSELTGWDETTEAIAHDRGSCLFLGDFNCHHPMWGGHGAQRDTRAQQLLNYTLGNGLDLITPEGIPTFRRNGARGTIQETVIDLTFATGDLLKSIHACRPREDWCIRHDHIPIEIILTTGQMLNLERRRCVYHKANLEKMKSMIRECKWEQAQQPLVALQEVIIQALNEHCPRAHPSPFAKPAWSAKATELVANARSSRRQALATKEDHDVTRAKLIRQELKKEIRRLKRSSWRSFVASSTDTRGDHNRGLWNLSKWAKKSTNIVQGPPHLPGLRRSETDPPTDDNRSKVAILSDKFFPKRVEADLSDMELIQQAKRHTIAIPDVTPDEVGRILKQLPRNKAPGPDEIPNEILQALLYDWRVDLAQAIRSLLRNGQIPSSFKESITLTIRKERHPDYTLPSSYRPIALENSLAKIVEKLVANRMIEAAEQHNMLPWAQMGARKNRSTILALELLTSTVQTAWEARPSRVVSMLGLDIKGAFDNVSKRRLLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG9</accession>
    <name>A0A0B1NZG9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004264">
        <property type="protein sequence ID" value="KHJ30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG9"/>
    <dbReference type="HOGENOM" id="CLU_700563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="45333" checksum="1A63AD653FF7C704" modified="2015-03-04" version="1">MFAGDAREKYLDLTLHDNHLTFDDRCDLIKSHYETDHWINRRKTVWNTINLIEEMRKCSDKPEAFNNLERKLRCIQRGLQSHAGDAALRTQIINACSGVAELHFVLFSPAKTAEGVCSDIRARFMQLSLSNTSSSQYHQLEYPERGYDSTYLAERHYQTARGQGKGQGNRIFNSKIKNNGKEFRAADSKWNKCCIVCKKTNCWSSEHTPEERRAAFDKVRNTYPTKTENAVQQFILQFEGESPVSELHHFLTINEPNDEIDPDEENLYEKDTYQYLTSEIGEINALTYLQNKTIPHKFTAPKLKFATPDREEGRIITADSLNFDTFCNNDDNISKEFNIKTSKPNEFYLFNEQFSIECYNNKYDERIFHGVLVDTGAAGHSTVGIGQAKALQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS4</accession>
    <name>A0A0B1NZS4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005227">
        <property type="protein sequence ID" value="KHJ30084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZS4"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_4_1"/>
    <dbReference type="OMA" id="VIDCKHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="12992" checksum="5BB51D5060BA74FA" modified="2015-03-04" version="1">MATTAKQGQWIAQVLRDMGYPQYIARNAMTVQTRGDNQGAIHLVKNPILSERSKHIDISYHFVRDLAEKKRIAVEYIPTKDMIADGMTKPLPRVSYEKFVRELGLGENKSDDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZT9</accession>
    <name>A0A0B1NZT9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003990">
        <property type="protein sequence ID" value="KHJ30555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZT9"/>
    <dbReference type="HOGENOM" id="CLU_934454_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="298" mass="34891" checksum="E491F9A7D0D70815" modified="2015-03-04" version="1">MSEDFQGIRVWVEENSSVSWVMLLEAIFTMMQQLDLLHSPRTIFTRLAVNTGENIVSFASRLRSAFYQLSKNDRECDSVRDTFVDIVKTGMPQVWLHVQPQMKDKSTREGIELLVQIANRMMSWPSQINLCTNSATSFPTPQVNIANPLLNDTQVFPSNNTDIPLHPYLTTESALPIRDDTCHICKRKGHWAKDCLQKNHRYMQPHHNRQLQNDDRYDNLKKRFSNLINKKRQPELSNKRYYKPNNNQKSYLVELNDKNTDELLYETCPNNNCEHHEQIDTDDELDKIFAEINDDNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW1</accession>
    <name>A0A0B1NZW1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ccaat-binding factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW1"/>
    <dbReference type="HOGENOM" id="CLU_066247_10_2_1"/>
    <dbReference type="OMA" id="EDHSMEQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20642" checksum="29DD7EE2D111EB41" modified="2015-03-04" version="1">MSASPPKEDVEQPAESPPDDSDAQMNQDQQSSNPQELDVKEQDRWLPIANVARIMKIALPENAKIAKEAKECMQECVSEFIAFITSEASEKCQIEKRKTVNGEDILFAMTSLGFENYAETLKIYLSKYRETQTSRGENRPGSQGFVPNTVMETANTEVNLNTSADANVETDINTDANANMNVNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0M5</accession>
    <name>A0A0B1P0M5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">EV44_g1099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01004390">
        <property type="protein sequence ID" value="KHJ30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0M5"/>
    <dbReference type="SMR" id="A0A0B1P0M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0M5"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="276" mass="30590" checksum="D26EA48F583A2ABF" modified="2015-03-04" version="1">MAPTGDSEIQLLKEMVSKLELRVDQLEQSLSVAEAKVEGSRKSDGVRLILIGPPGAGKGTQAPKIKEKFGCCHLATGDMLRSQVAKKTQLGNEAKKIMDQGGLVSDEIVIGMIKQELETNEECKRGFILDGFPRTVLQAERLDSMLSKRQQKLQSAVELQIDDSLLVSRITGRLIHPASGRSYHKIFNPPRRDMADDITGEPLIQRSDDNVDALRKRLVTYHQQTAPVVQYYQKTGIWKGIDASQEPGQVWKSLLSAIEDPSKEKSGGLLRKIIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y9</accession>
    <name>A0A0B1P0Y9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mfs transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002492">
        <property type="protein sequence ID" value="KHJ31893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Y9"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_2_1"/>
    <dbReference type="OMA" id="GICAKME"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="39853" checksum="F3685644A049A3C3" modified="2015-03-04" version="1">MRNHNEFGAVYELLQNSGCQNSFEDIPESLREKSDEERVALEKKLKRKIDLRLIPMLVLIYIMNYLDRGNIAAAKIAGLPEDLNLKGSEYQWAVSVLFFGYILMQVPSNLYLNRIGKPGIYLPACMLAWGLVSTCMAASHNFRDLLICRLFLGFAEAAYFPGCLFYLSCWYTRAELTFRTAIFFSGSIISGAVSGLVSSGICAKMEGLKGLRAWRWLFILEGITTMFVAFLSFFILPDLPHTTTFLSTEERELALWRLEKDTCEQTVSEDKHQSFLTGALLAAKDIKVYVLMLLIHCIAVASSVVTYFPSIVKTLNYNRVTTFLLTVPPFALAVITTYFNAWHAGKSILNPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P153</accession>
    <name>A0A0B1P153_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01003333">
        <property type="protein sequence ID" value="KHJ31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P153"/>
    <dbReference type="STRING" id="52586.A0A0B1P153"/>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="OMA" id="FKTEGQW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="370" mass="40899" checksum="C5A0F42BA2AD21AB" modified="2015-03-04" version="1">MTHLAMSRATTCRLITSVSNSSLHAEARSPSTALKVANNGSNILEPCDLPFKFETGTALFAKKNARPFPPPFLSPPSRSFSDPLSTYNRSRDTRVSMDYEALRGITNGDDAVYVGRYFIAANDGVGAWSSRPGGHSGLWARLILHFWAQEMEKDLNEPDPIKHLQNAYEKTIQATSESNICQGTTTVTGAQLYYQPSCGKLGTSATPLLYVTNLGDSQVLVLRPRKSKIIFKTTQQWHRFDCPRQLGTNSPDTPRQDASLDLVEIEENDIVLAVSDGVIDNLWEHEILENVMKSIKKWESRKTDQSYKENSGAAEQMKHVAEELMKAAKAIATNPHAESPYMEHALEEGLTIEGGKLDDISVVAAICKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P195</accession>
    <name>A0A0B1P195_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0774</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01002121">
        <property type="protein sequence ID" value="KHJ32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P195"/>
    <dbReference type="STRING" id="52586.A0A0B1P195"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="OMA" id="CTALQWM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="469"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="566"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="613" mass="69873" checksum="DC19C947C6CC1E7C" modified="2015-03-04" version="1">MTLTRDPNTYSNYNQWKTRHTDVDLVIVFEEQRLTGNINLTLESLTDKESEEVILDTSFLDIKSINIAGSKSTEWLVRDRSEPFGSPLYIKIPGGISKGSILSVDISLSTTDKCTAIQWLKPAQTSNKKYPYMFSQCQAIHNRSIFPCQDTPDVKSTYKFRIRSPLPVVASGLFTGASKFEQKEDKNPGSLLYSFDQQIPIPSYLFAIASGDIATASIGPRSLVSTGPEELPSAKWELEKDTEKFIEIAENLIFSYPWTQYNVLVLPPSFPYGGMENPIFTFATPTIISGDRGNVDVIAHELSHSWSGNLVSNASWEHFWLNEGWTTYLERRILSAVHGEAHRDFFAIIGWKALEDSVTMFGSDHEFTKLVIDLRGRDPDDAFSSVPYEKGFHLLYHLEKLLGKPNFDRFIPHYFCKWSMKSLDSYDFKSTLFEFFSSDSEAQSKLESVDWDSWFHKPGLPPKPQFDTSLVDKCYSLASKWQSEQFIPSVSDTVDWNANQVVVFLEQVQLFPKPLSVSQSRAMGQTYSLIESKNVEISSRYISIGLLARDPTVYQLAADLLGKVGRMKFVRPLYRKLVLVNCQLALDTFEKNKEFYHPICRAQLQKDLEQFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B5</accession>
    <name>A0A0B1P1B5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative perilipin mpl1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003742">
        <property type="protein sequence ID" value="KHJ30701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B5"/>
    <dbReference type="HOGENOM" id="CLU_082150_0_0_1"/>
    <dbReference type="OMA" id="YSYVAPY"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17316">
        <property type="entry name" value="Perilipin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="20509" checksum="D60AF619306F17C1" modified="2015-03-04" version="1">MPHFAEANDMSSQLNGESRPNSAFLSHLKSYPIVSDGITTFTSNPYGAKSLSLTTSSYEKISKPLLPYLRMPIAYISPYAARADSIGNSTLSSLEEIFPVVKKPTGELIEEGKSVVFFPLRKGCEGRDYVKGVFGSEKKKFGDAGLINYGKAALATSLVISSDALNWLNGYLAAKTDQAKEIKKEKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1G0</accession>
    <name>A0A0B1P1G0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0443</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002067">
        <property type="protein sequence ID" value="KHJ32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1G0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1G0"/>
    <dbReference type="HOGENOM" id="CLU_027285_2_1_1"/>
    <dbReference type="OMA" id="YEHKAHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058817" description="Probable beta-glucosidase btgE" evidence="14">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="450" mass="48274" checksum="5E0348C7C43ECCFD" modified="2015-03-04" version="1">MKAKSLIFMMALVTSATAEIQFDARDRIELMHLRRNKPLMTASAESSCGCTTLYSTFTGEGVLLFPPTPSTSTKLVAQPTPDYPHIDKDTCPTPATITVTETNFISTTPGPSTVPTDSIEPDVIHTTDKNDSDVAHATETPEPDMAHTTDTPESPVLTIPGLYLPSPPSSTPKAQVPAAPNTDSLGSKNGMWAITFSLFNDDGKCKSVTTVWAEVNMIRIAGFKSIRVYGTECDGIENISTATSFHGMKLIIGVFIGETGCSGAKEQVNHIVKWGKWDLVELIVIGNEALFSGHASPEELAEFITSTKITLRSAGYNGPCTTAEPLNIWEKNSGALCGAVDVVGCNIHPFFNPEIDASHAGLFVKSQLEIVEKICPGKHGINLECGWPSAGECNGKACPGVSEQETAVSSIQSFAGNTSVMFTFSNDKWKNPGRFHVEQSFGLIKLLTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q9</accession>
    <name>A0A0B1P1Q9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003655">
        <property type="protein sequence ID" value="KHJ30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q9"/>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="23293" checksum="BA0F4A91F7E37AD2" modified="2015-03-04" version="1">MMASTTAKAYPQGGTIIDTFKRSFTDVPVDEEKDNSISSTEFLEAAESMTALFDILGSLAFQPVKKDILGNIKKIRDRQLAAPAESLSLQELVINELKTKKHTASEGLLWLTRGLEFTAAALAQNVAHPNEELSVSFRGAYAETLKPHHSFVVKPIFSAAMSACPYRKDFYDKLGDDETKVIKALQDWIAALQKIIVILKSFLAKKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P212</accession>
    <name>A0A0B1P212_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002986">
        <property type="protein sequence ID" value="KHJ31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P212"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10853" checksum="D2FFF7C7A08EDC3B" modified="2015-03-04" version="1">MAATKCRNCGGAHRADSRRCLARPTRSGAPFKEQLKIYRQAGEREYQAVLRARVVEEKAATTESINIDLTSSQITEINSSTDNIQVTPDEVSTGVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P274</accession>
    <name>A0A0B1P274_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transcriptional activator hac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002138">
        <property type="protein sequence ID" value="KHJ32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P274"/>
    <dbReference type="STRING" id="52586.A0A0B1P274"/>
    <dbReference type="HOGENOM" id="CLU_035741_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="105"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="31786" checksum="F409A7B34B63A162" modified="2015-03-04" version="1">METIEAMGVTTLIKYEQSPAENEINSFVSTPGSFYPTLFDNTINPIEALTPQSLDGDCHFNAKLPGITSPEKKLVKKRKSWGQQLPEPKTNLPPRKRAKTEDEKEQRRVERVLRNRRAAQSSRERKRQEVEALEAEKRAIERKNMDLEMRLADLRAKYHLLQMEMEWFDCGKNSHRSYSGTSSSHSPELRQPSPITFSMELFSSQDDIVRPFSPQSISSPASGTVDPTILSPESQVSMESPSASPSELTHHTASMMYDQQCQSEAFELWMDLTSATSMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2E2</accession>
    <name>A0A0B1P2E2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003246">
        <property type="protein sequence ID" value="KHJ31116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2E2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2E2"/>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="OMA" id="TKDRYVP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17055">
        <property type="entry name" value="Ubl_AtNPL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="263"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="638" mass="71479" checksum="E05DF246B265C376" modified="2015-03-04" version="1">MLLRFRGPDGMVRIVADRDDTFGELEHKLSKVLPEDVDYETLILSNKPAGGDNKLLKEISKYKISQIGLGHGDMVFLNYKKIESPSTELYSNTATTRASDYSSSANKQIGISPLKSYDQNVSISALNQGDSKKGTESIYQSELDDRLDKKDGRIIRKRDHKMCRHGEKGMCDYCMPLEPFDPGYMHDNNIKNLSFHSYLRKINSTTNKSGQGSSFMPPLSEPYYRVKNKCPSGHPEWPGGICTKCQPSAITLQPQPFRMIDHVEFSKPSIVENFLNFWRISGCQRFGYLYGRYSEYTEVPLGIKAVVEAIYEPPQSGEIDGITLTEWENKEGIDEVASLCGLEKVGVIWTDLLDSGKGDGTVFCKRHIDSYYLSSLEIVFAARLQAKYPKSTKWSDSGKFGSNLVTCVLSGDTSNQIAISAYQVSNSAIEMVRADIVEPSADPGKMLVRSEHNEDSNQSISYIPEVFYRRINEYGCSVQENAKPSFPVEYLLVTLTHGFPSNPKPLFIAPDPGFPIENRSIIGIDQDIKAISKHLEFGKNLMGEEPIFHISAVSDFHLLCYLHTFGWLDKNEEALLCLVATQHDEIEGKKLSYTSGWNTLVAVIQSTGERPLKRLSPIDCDGSNSERLAKRIGVVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G2</accession>
    <name>A0A0B1P2G2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002049">
        <property type="protein sequence ID" value="KHJ32483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G2"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_12_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="258"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="632"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="79716" checksum="BC1E011569B81790" modified="2015-03-04" version="1">MLETDASDGVVAGVLSQKHGDDWLPVAFFSKTLAPAELNYAVYDKEMLAIARWSEVLADFNFLISYRPGVHNPLADTLTRRINEVDSQNLAKKSQRLQQLLRDNQVDPVILLSRELRTNTATEALINSFDLKPISTDLNIVDMILKANRNSSSLQALRKQATSNIPGPFSMENGLLLYNDRLIVPDTNNLRTLIIREAHDQISSAHLSAKKTLRLLPKRNYWKGMSNHISQYCRNCHLCRRSSVPLDKKPGFLHQLPIPSRPWEHVTMDFCCFNKDKHGYDKVLVIIDRFSKQAISMPAKLKSSPSRGAGVNAQPSILSISGIAKNIRTILPFRTPIHHRGSQSSSFLHHSPLSTFFHEAPHDWPREYRVKGSILSQRTSDENELLVQMVGCWLDFLEVFISAFWNEFNKILGTKVKLSTANHPQTDGQTEIYNQYLQKRLRLFVNYYQNNWSELLPIMDYAQLILPHDSLGGLSPFEIVHGYPARTTWDWKIKDDVPPPEKLDIEDARKMIKQQHDAWSLAKSHLLQAQSRMARKSNIHRREINFDVGDYVWLDMRDFLTQRPTKKLDFPTNGKFLITEKVGNSFRLALPTSMKVHNIFPPEKLRLASSDLLPGQINDEPLPINITGDDEWEIEKVLASRVKRQRLEYRVAWLNKDEDLDWISASDLKYAPHKIKEFHLQNPNQRGPPAQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2K5</accession>
    <name>A0A0B1P2K5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional coactivator hfi1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003495">
        <property type="protein sequence ID" value="KHJ30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2K5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2K5"/>
    <dbReference type="HOGENOM" id="CLU_038277_1_0_1"/>
    <dbReference type="OMA" id="EMAFTRG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="51639" checksum="0353A0C272C814A4" modified="2015-03-04" version="1">MQQCMIFGHTLRHIIHGKLHTITNPAALNNSTTLSSSTQPQKLSSTPVQNVSRLAKPGIGPPPPRINLEPLYMALKIAFGENWPTYKDALIKFLSGNLNQAELSAQIDHFIVTSKGEKEHLHNQLISAIYGNTTRELPDHNIATWVSANDKPFIASAKLSSGDAAEQRLKVEVMQLPRKDRQRLKQLSKNDDDPEEIFSNIFGENRRPKSVPKLAEPFSASAGGSFQMTNLDVEIRKRYVHPLASESGEFPDTTSIESRMLPICYETGILSGHASDAPHFMSVATETFIKEVLSSIFTKTQSNGPGTSGTAGTGGGANWIQTHKYRTQLVKEEEASLRGETLRDKSGLLPIEARSAVERGPLGMADVRMALELGDCGIGQMPVVLQQIMLSYREGEIDLWDDFTWLESQLHIVDKHLEANDKDVEMSDVRDVTGCAYETSPEEWGWEGCEPEDMAKLDDLLDSCLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P318</accession>
    <name>A0A0B1P318_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001890">
        <property type="protein sequence ID" value="KHJ32678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P318"/>
    <dbReference type="HOGENOM" id="CLU_582917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="464" mass="51778" checksum="DB55EC048A551C50" modified="2015-03-04" version="1">MLINPEAPMTNDPKNDTSVTKTMTEASSVKKTANTGKNLHTSLHSIVVAMEQAENERKEGLALAQEFLELIDTWAKAKEDTYAAALVVPFIQKIAPIVTSFATGITCSGQTAPSFCFENKKKITPAVSKATNRSERRRMDTTTQKPPRDTWAAVTSRAAALPHPTIAQTHNNQVNQIKTVQNREQKEDKRLFLRLDPNHEWKKLSPSTIKKMIIERAGVAASAIATIYSVLSGLAIECVSDALRESILGIGQTFLQNGAIIEAASDWTSYIIPHVPHYIRILDERILVTDEMVKKECRTVCGVVPVVARPMKTKLEQQSTGWLVHFKQKPPRNGFRLFDESGPAMPFTRRRPIEQCQRCCGFHPTRTCTKAQRCKRCSKSHEAYECKEQVPKCSNCAGPHESTDLKCMARPCRQNGIVTLRTPAEPRVIRERGNRDFVAVLAESKKKDNTTDVAIIQEVTKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P326</accession>
    <name>A0A0B1P326_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosome assembly protein noc2 nucleolar complex protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003016">
        <property type="protein sequence ID" value="KHJ31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P326"/>
    <dbReference type="STRING" id="52586.A0A0B1P326"/>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="740" mass="84274" checksum="5149FD992EF651B2" modified="2015-03-04" version="1">MGKSAKKSTRKYEKNQLKDALERRKAGAKIKQRQQIKLKRKAKNAEKSYEKNEKDSGIHSVTEQDPVAKISVDNFFQNGIEIPEKTINAPESKSSERKNGKQKRKYQEADDNIQFETPVIDGSDLSDSEKEESGEEDDIGMSKDIMDGLAEKDPEFYKYLKENDPDTLDFDENSSLSELNVTSALDEEKPRKKRKKTNLSEDEETESSIIQIATVEKWTKAMTKNYSLRAMRQVVLAFRAAAHVNEDENKHKYSISSPDVYHNLVISALKYIPIVLQHHLPVKESSGKSRVSTESKKFKTLTPLLKSHSISINHLLSNLSDSSTIKATLSSITILIPYLVSFKKILKIIIKTVVGIWADISHSEAIRITAFLALRRLTVEGDAGIRETVLKTVYQGLVRSSRSTTMHTIHGINLMKNSASELWGIDAPVGYATGFTFIRQLAIHLRNSITKNQKESFKTVYNWQYLHSLDFWSCVLSEHCSPLREAENGKESELKPLIYPTVQITLGALRLIPTAMYFPLRFHLIRSLLRLSRATGTYIPLASSLLEVLNSNEMKNPPKSSVLKPIEFALNYKVPKSYLHTRVYQENIGEQVVELFAEFFVIWCTNIAYPELALPVVVMLKRWLKDVKCRNKGNKNAKVSNSIALLIQKLETNSKWIEEKRAKVDFAPNNRVGVDEFLKGFDLEKTPLGAFVMGQRKLRESKMKIIEEGRKKDEEVKKKIDKRQGSKEIDQDLSDEEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3B6</accession>
    <name>A0A0B1P3B6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001835">
        <property type="protein sequence ID" value="KHJ32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3B6"/>
    <dbReference type="HOGENOM" id="CLU_1103461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="27238" checksum="885279F0C0E2D226" modified="2015-03-04" version="1">MASIGQAQLPRIEVYSPSGSSKMSQESSRLVSRSKSKFNDPFRDKYSIKASAAQGTLSYGREIQMNETSSQPSLIGTGEAAYRNKGITSKSSSSLEIQDRLAKNLDKTEDSEIIADQGTNEELSSKIDEVTNLLPVPGILLLSSNNPTLTSISEAPNNIVPIHDTNVPLEPAFSDNGIGCPVAPEIPALAIQKSSNSKKGKKTLKQGYRMTRRAIMRKGVLQILVGRELAGPAKEIIKRSCEGPAEMENTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D6</accession>
    <name>A0A0B1P3D6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002564">
        <property type="protein sequence ID" value="KHJ31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D6"/>
    <dbReference type="HOGENOM" id="CLU_494486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="65768" checksum="238DEB89C03575ED" modified="2015-03-04" version="1">MARLNEDEVISENDGVFRDINRRNTITAKIDNLPVNELGLKKDVLQLADHVCQLYDHWKMHSEEFGVDYDLRNKRRQTLLSLNHTISNKRDEFQATNEIEILDLREHTDWFINNNADLNIRFTSEEVFKEAVNNQPRVWFLFLKYISNSLHYADLHIGSQDNEVDNLRSSNEELSSGSYPNPLTNDKRTKYSNEILRLRKEIDIISKERDTLRAKNNLHEIDSDDEFLNHDCTHNQPHDHSTKPPMITHSRPTTYENVMTHQINSPTVKYGSNKPSDKIDVFDGKVREKYDEWVDKFLGQIKTYSDWFIDEDRKLTYLMRHLTGPPYNLLKDKYDERARLNPLHGRTLMNALAELDRAFRARNIRLDAKTKLETLRMGNNQSFGDFFAKFQIQINKLNYNDEDKIDELKSRLNFRFASRIISGRKESYDELVDHFYTLDSELSMYEAKKAGISLNNPRNLPDIPLSNGKPHLDHATVELGKSSKPLAEMTLKELKDYRNSLPRSAVIKQRLQDEKRCHRYMQKGYTGLDQVCQFNRLPQTEKFKQKAFVNSISASDEGNGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K7</accession>
    <name>A0A0B1P3K7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fha domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003079">
        <property type="protein sequence ID" value="KHJ31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3K7"/>
    <dbReference type="STRING" id="52586.A0A0B1P3K7"/>
    <dbReference type="HOGENOM" id="CLU_398600_0_0_1"/>
    <dbReference type="OMA" id="EVESCTI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="691" mass="76383" checksum="7107DC0B31B2C4DD" modified="2015-03-04" version="1">MMSIQAKITFTSLNDSIFPAKRVITLNSRLSKITVGRASKSSSKSLFSAGDNAWFDSPVMSRDHAEISLDSKCETLLLRDVGSMHGTSINNSQLVSYVPTSLCNGDVVIFGTEVKRGTETYPPCKFIVNYEISSQKTANTFAYPESSDFDDDDDISLGESDIEQNQVIGTVNDRNIKTIDSLLDSNHSPRISSNSNVAPISINEKVEGKVLESKKPATEKTTGGLEDIKKYRDLGKITPKSKEHTTSKSDDGRQSSLNPNSQNPIGLGILNVPKGITETQKLDTNKPTEKSTYSEASPRIAEAEAEASGDNIKNTTKPCNLANEPSINYYSSDGESDTQSEYRLSSCTDEELRVLLDDDLNSNHGSSLTFYNYDNHRDKKDKEQYNSSQCTAAESRLSPSITSTQYFMSSVTSSSRSVLSEHDDKCSIKSDENVLKNLTPQREKNLQTRVNRPSKSEETLEEERLRKLAFFKAREYNKAKFNLQANKDDRTSQNTPLKRQLPKQTCFKSPKALDEQSFVSTLIDNNQNDSPQKINGFNQYSLINISTPEDMKRDVNCGSSTDSSAVLNSGEEFTSKKAIKYQNENKLSVLSPTSNCNESGSLKCRKRKADELSGNSEDEVESCTIDSFFAPRDTINKNSAEAYHEKSTSYHSAPLSKRRKIMESLGYVALGSFAAAAGLFSVLVATAPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q2</accession>
    <name>A0A0B1P4Q2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g3071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Q2"/>
    <dbReference type="HOGENOM" id="CLU_017633_7_0_1"/>
    <dbReference type="OMA" id="IIGCRGC"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="13">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="20224" checksum="44592FFFB40F48CA" modified="2015-03-04" version="1">MSEFKSEFTDYKLTYYEILGLSEEFQKSPSISSKKLRAAYRHTLLQHHPDKTSSSITRRNRQTFTVDQISQAFSTLLDPLSKAKYDHEIKMRRILSADSRKGADDSVGMETIDLEELESDEHNKLWYKSCRCGNGQGYLILEKDLEAAVHDQEIYVECRGCSLMLKVLFAINEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R9</accession>
    <name>A0A0B1P4R9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002681">
        <property type="protein sequence ID" value="KHJ31674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4R9"/>
    <dbReference type="HOGENOM" id="CLU_001645_9_12_1"/>
    <dbReference type="OMA" id="WSIDKAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="44174" checksum="EA9E79FA72C04908" modified="2015-03-04" version="1">MAFCGNDKSNKSSENKTHLNHDQYMAKVYGNEYLNCRLPVFLTLSPNVISHKFNLISQYEATLAAKPSAILSHVHLSQRDRYINIRPWAHNAIQLKNAQKFPDNYINASPISLGRNQEIFIATQGPGPGDTILHFWQMIWQERAEVIVMLTKFVEDGTEKCGVYMPLQKADVLILKPRTGPVWGKVECETLQKEDWGEIRQLRIMKNSESQLFEERLVYHLLFMRWPDHKVPREKNDRMALINLINLSREKMSHNVDSPKVNTPPRIIHCSAGVGRTGTFIALDHLLHELEENKLDYIGDEDDPILNTVQRLREQRMGLVNNVQQYALIYQILRERWELRRTHIFGTASVMRDHKVSSAITNHMRLTSTLKRKFQNLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P569</accession>
    <name>A0A0B1P569_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01001434">
        <property type="protein sequence ID" value="KHJ33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P569"/>
    <dbReference type="STRING" id="52586.A0A0B1P569"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000015">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="317"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="718" mass="79570" checksum="6045EC25ADD7885B" modified="2015-03-04" version="1">MDRQSVYSLSVLPPDYGNDDTRGRIQNQLEQFILQFRLDNVFIYRDQIRENILVKQYYCDVDVGHLISFNEELAHRLTTEPAEIIPLFEAALKRCTQRIVYSSVRDVVIPEHQLLLHSSAGEISIRNLDALTISRLVIVPGIVIGASVPSSKATALHIQCKNCRQTKILPVTGGFAGISLPRVCDRPKMPGEDSCPMDPFVVVHESSQFVDQQIIKLQEAPDQVPVGELPRHVLISTDRYLTNRVVPGTRCKIMGIFSIYQNKQSKISGSASAVAIRTPYLRAVGIHSDVDHTAKRSSIFSEEEEQEFLEISRRPDIYSILANCIAPSIYGNQDIKKAIACLLFGGSKKILPDGMKLRGDINVLLLGDPGTAKSQLLKFVEKVAPIAIYTSGKGSSAAGLTASVQRDASTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNARTSVLAAANPIFGRYDDLKTPGENIDFQTTILSRFDMIFIVKDEHDRGRDEKMAKHVMGIHMGSHGAEVQAEAEISVDKMKRYISYCKSRCAPRLSPEAAEKLSSHFVSIRKQVHRAELEANTRSSIPITIRQLEAIIRITESLAKLSLSPIASESHVDEAIRLFLASTMDAVKMGAGQGSQELNKEIHLLEDEMRRRLPIGWSTSLSTLKRELCQAKGFSESALARALIVMQRKDTITIRGQGNQVYRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F4</accession>
    <name>A0A0B1P5F4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001980">
        <property type="protein sequence ID" value="KHJ32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5F4"/>
    <dbReference type="HOGENOM" id="CLU_331269_0_0_1"/>
    <dbReference type="OMA" id="MPMSSEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061884" evidence="2">
        <location>
            <begin position="19"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="865" mass="85299" checksum="4B11F0BBDB6DF1AD" modified="2015-03-04" version="1">MKFNTAFIALSLTAKSLGYPSSLAKRVKISSVGDVSGSEVISSGKTVGGTGLDALTSVQAEGAASAETKSTNGLNNLSEILSILSGNQGATSVVSSTGGSKNDEDEKSGKNIGNKGPAGAVSAAEETKDQKNKASNSEKSHDSSSSSKKQANSAENESQSIQEVTIGGKAGVLVGGGNGSNSLASGLGALTTKGKSGEEKKAKKADEVNAEAEGEDGDEEENPSKTKGSGKEDTAKAENSNVGIVVDGKEIPIDSDNITGLLTAGKDAEGVAAKSEAKSNGIQNNQKSSNHDTKKVDEAETKEKESKSDISSTSGKSDIKINDKENSLGSSASLGIGSTEKKEKKKAESNNKEKDLSQASEEEGTGNSEAPEKENKNAKLGGAHRLTFGESQLSFGESQTKSELKGTAAGKSKNPEDDALALSESVQAQATSAGDKALAEADEVLAKGEEALALSENLQAESTAKGDEAQAQVQGKGNSIPGTSKALQVKAEASEVGGNPEAEDQGGDESLNSIAQASGGLDEEGNIGPMNGSDDNKSKGEAVKSQPSKASAAQECNAILSSKAADAEEKAGKTEEIGKKSAKAKETETEAEATHAGGKEKEIAEDEQQETAPQAGGNEKEIAEDEQQDKATQAGGNEKEIAEDEQGDDEAANVEEEDCRQLLASQSGATSKLEVGPGGPRASGASGGPGGPGGPRASGGPGGPGGPGGPGGPGGPGGPGGPGGPGGPGGPRGAGGAGGPRGPGGPGGPGGAGGPRGPGGPGGPGGPGGPRGLNAQETQEPEGKSKSEGESKPAEVQAIGKQPKSGEELSLADKQAPQAGQAGQAGQAELAELAELAGQGGQGGQAGQAGQAGQAGQAKQASQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q0</accession>
    <name>A0A0B1P5Q0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01002230">
        <property type="protein sequence ID" value="KHJ32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Q0"/>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="165"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="739" mass="84334" checksum="BB491CA83BEF1B40" modified="2015-03-04" version="1">MPRNRPQITGYSRIAQAEEEESDLDDDLVNGYTSIQPASLPQFSSTYPGNNNKTPSDGNKSTDTGKKLKSRKTTRRNSSGVDVRAINARLERWADEITAKFKINKIKGKTDEEEKLEIYHSVFQAPDGIRPATAETLAAKDGQGRMSKQEFDEIVESVRIAIENGIHPKMIAQGSSGSYFARNSDGKIVGVFKPKDEEPYAAGNPKWNKWIHRNLFPCFFGRACLIPNLSYVSEAAAYTLDCRLRTNLVPYTDIVHLSSKSFHYDFWHRRNYYKRKKRFPPKVGSFQVFLEGYKDANIFLREHAWPDHTESEYRPVGAPQKRTKDTETSGKRQNRRFFWTDNLQQSFREELEKLVVLDYIMRNTDRGLDNWMIKVDRKKEKNSNSPEIPIQVISNEVGASPSLESSDGTSESGPYRQQKPMKVDSTSSTLKNSKATKITIGAIDNSLSWPWKHPDAWRSFPFGWLFLPVSLIGQPFSKKTRDHFLPLLTSKQWWSETQMELRKVFSQDVDFKERMFARQIAVMKGQAWNVVETLKMADHGPLELTRRARVCVWDDLVDIPIAIPMKMPSGEMRLRRDQALQEEVDISAANSSAQQSDLLGIVNSPSELPNANRFELACPSTRDNIQSKEIGLNRPKDLSINSEDQKDDSINLSIRPSKNLSRNRMSYDGPQREQIHDPQLSRRFSFSYKTSVNSFNCGGDDLEGDLGYAAAEGMEGNHLKVIVERLETVKSKNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B3</accession>
    <name>A0A0B1P6B3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sam domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000984">
        <property type="protein sequence ID" value="KHJ34227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6B3"/>
    <dbReference type="HOGENOM" id="CLU_011433_0_0_1"/>
    <dbReference type="OMA" id="YYGWMKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="738"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="667"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="966" mass="107388" checksum="5F699F8152932DF2" modified="2015-03-04" version="1">MTLRTVEAMGAPEPGHILLVVHDFSARSSDELSLSKGDRVELIERDDDFGDGWFLGRHLLNGKSGLFPEVYTRIAPRGSLICSPASSSIQNSNSKIRKTSNTVSPQTPFSGENTVSLPSEPLKMLDTPQIQPTLGPRGIKAPSNLTITSPETMIQSKSISSVNIKNHRQDSPVMNETLSVIDEHITHLKSPHGIVDRDRQVISDSGSEYSSQTDQRLSYINGEETDQDEEDIIFTREQVASWTSEEVSEHLFTRGVEPKHCEILRDQEITGDVLLDMDQATIFLKEFDFGSVGRRLKTWQRIKSIQDEVEGDTSSKRNTTNYMSEVGEEISRNKTRSANSSHTLPRMSSTHERQKISLNSRLSNQNSLWTDSVQALPTVSKISPEICYSDADKTRYPLIPQDQYHSRQNSSNQTATAFLGSNLSLTLKSPVHATQDRTHKKRGSFDKNWTMQNSNSSYSGQPSSSIHVKVAKKSSACSSTDDLFNVENLTSSIDPLGSNYFVSNETESGVKNIIRRRESPSVNIASQSRRSSLADEQKVRNSPAQRVHSRFGSIDSIRDAPPHSAEKYFSIGVTSNRRRTPSETSLSILSRAYYSKDQPLSVSPTIMKLEGEPMRSFDVRPDKSDFITSIKSASNGRFGLRAISSAVTGHEKSRVVKSPPELNLYPPLKFSPIQSPPRTGSSTPSGGFSFDLESPDLKGASTYSTNNSNGRIKKKTKKETSAYTRGLEKKKPQEAILNADYSGWMKKKSTNLMASWKPRLFILKGRRLSYYYSEDDDEERGLIDISFHRVLPADNDRLTGLHATLTGATNTKSHGLDNSISAFQSATEAEPKPDKGNDSVFIFKLVPPKAGLQRAVTFTKPTIHYFAVPNVKQGRLWMAALMKATIERDETVQLKSTYQQKTISLTKARAMRHRPPALKEDISEAIKSTESDENFMETTGIVYHTDPLEGDSGVSGVSNSNSHMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6E6</accession>
    <name>A0A0B1P6E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002228">
        <property type="protein sequence ID" value="KHJ32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6E6"/>
    <dbReference type="HOGENOM" id="CLU_036943_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="18355" checksum="980B4D6AB565687B" modified="2015-03-04" version="1">MTKARGLLNLVGPYLEEMELECPGLGTGFLALMSDGVSRAIRGEKIYTNIDVLLRNASTPPSNNRNTWAARAARGNNLSLNNSVWGPPAKPSNPPRGQSFEDRRIMIRLEHDHEAHKAESFLLRQQIQSLISDPSLVSDAWQALSGIAILAPTPAKAATLLQYKDVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M4</accession>
    <name>A0A0B1P6M4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001958">
        <property type="protein sequence ID" value="KHJ32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M4"/>
    <dbReference type="HOGENOM" id="CLU_1797875_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="16325" checksum="28FE01B889A97725" modified="2015-03-04" version="1">MISDQRPAPEVWNSNKTKITISRGHGSLRSTSSFAKAIHMDLVGGQKSLTPTTIDNSKVSLANSTARNYNYNTWKWAWPDYTKKTVPSQIRYLLEHLETKFSKTPTRIHTDGGTEFSNAELQEILLSCDIEWHKSSSHATEKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T7</accession>
    <name>A0A0B1P6T7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative had-superfamily subfamily iia hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001915">
        <property type="protein sequence ID" value="KHJ32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T7"/>
    <dbReference type="HOGENOM" id="CLU_030880_2_2_1"/>
    <dbReference type="OMA" id="ECAENDW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="29769" checksum="F0B0F23688B61C8A" modified="2015-03-04" version="1">MVEKYKTVLVVGGEGEKCREVAEGYGFQDVVTPGDIIKYNEATTPFRRLTNEERARSRRRDFSKTRIEAIFVFADSRDWASDIQIMLDLAMSKGGYIGTLSDTFDEGPTIYFSHNDIVWSAAHDNVRIGMGALRKMVEILFKDLTKGKELETIAFGKPQIGTFQFATRLLQQWRKEEHHINRPPETVYFVGDTPESDIKGTNNYNENAKNDWYSILVNTGVYQEGTEPTYKPRVNVSTVLDAVQYGIKREMEWKLEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W1</accession>
    <name>A0A0B1P6W1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative chromatin remodelling complex atpase chain isw1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001628">
        <property type="protein sequence ID" value="KHJ33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W1"/>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000005">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="183"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="479"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="846"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1113" mass="127767" checksum="C7DF2CE472E69739" modified="2015-03-04" version="1">MADEILKETNTETMDVDGTPELTEDSDTNPNTTPSSLAEENSNEDGRKRRSIATQLRRSVFGKKHDILGESKEDDSIRRFRYLLGLTDLFRHFIETNSNPRVQEILHEIDRQNADKDKAKKGRDRQGGAAAERRRKNEAEEDAELLKDEKDGCPAETVFRESPGFIQGGVMRDYQVAGLNWLISLHENGISGILADEMGLGKTLQTISFLGYLRYILGITGPHLVIVPKSTLDNWKREFGKWTPEVNVLVLQGAKDERHQLINDRLVDERFDVCITSYEMILREKSHLKKFAWEYIIIDEAHRIKNEESSLAQVIRMFDSRNRLLITGTPLQNNLHELWALLNFILPDVFGDSEAFDQWFSKQSGDQDTVVQQLHRVLRPFLLRRVKSDVEKSLLPKKEINLFIGMSDMQVKWYKKILEKDIDAVNGAGGKRESKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLIFNAGKMTMLDRLLVRLKKQGSRVLIFSQMSRLLDILEDYCVFRGFKYCRIDGGTAHEDRIAAIDEYNEPESEKFVFLLTTRAGGLGINLTSADIVVLYDSDWNPQADLQAMDRAHRIGQKKQVVVYRFVTENAIEEKVLERAAQKLRLDQLVIQQGRAQTTAKAAANKDELLNMIQHGAEKVFASKGATGALTEKGSDLNDDDIDEILKHGEQRTAELNARYEKLGIDDLQNFTSESAYEWNGQDFTSHKKEIGINWINPTKRERKEQSYSMDKYYKQALSTGGRTADVKPKAPRAPKQVNVHDYQFFPSALKEIQDRETAYHRKEMGYKVPLPEGPEDKLSDREAERASDQAYIDNAEALTEEEQELKQKLSQQGFSDWNRRDFQQFVNGSAKYGRKDYASIAIEVDSKNEQEVKEYAKVFWSRYSEINDFSKYISMIEAGEEKLRKIDHQRKILRKKMTQYRVPLQQLKINYSVSTTNKKIYTEEEDRFLLVLLDKYGIDSEGIYERIRDDIRDSPLFRFDWFFLSRTPTEISRRCNTLLTTITREFEEATAPKASNIVGNGKHKREVEDDNEDSNIQVMVPAKKRAKNGLKNRTLDNVKTSGGNKMSSASNRSRASSVASNAYSTTTSSSKSNPKSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Y4</accession>
    <name>A0A0B1P6Y4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002098">
        <property type="protein sequence ID" value="KHJ32419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Y4"/>
    <dbReference type="HOGENOM" id="CLU_1636672_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="18483" checksum="B7EA5D89B12036AA" modified="2015-03-04" version="1">MPKLLVNSFRTRSSLQIKYGNSRVDKDIRPQSKVTATQSRQVILSSINWLLGFFHTLASLASTTWLHGNYEWQWHLLNPFPVAQRQYYRSSSSTAVINVNTTSVSRKDVGDYHSLTGKDQLDDYLPCRQCKGARKDHEMVPKSSILESENLIRPTSVILKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z1</accession>
    <name>A0A0B1P6Z1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001617">
        <property type="protein sequence ID" value="KHJ33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Z1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Z1"/>
    <dbReference type="HOGENOM" id="CLU_064548_0_2_1"/>
    <dbReference type="OMA" id="WRIMQTD"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="23000" checksum="7DE7B802B2AF2EE1" modified="2015-03-04" version="1">MFSSSSQQRWLVIGKNYCKSFSSTTKILAKSTKQRLKFEHNEVPPYPYGPSQIYKQSNYGLYGTQKIRFGNMVSEKNEIKTRRHWRPNVQVKELYSESLCKNISIRITTRVLRTLRKVGGLDEYLLGEKSARIKELGMAGWKLRWQLMQTPKVKERFKKQRETLGLPPLEEELLPEQNQNIIIPKNDVKELPGPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P747</accession>
    <name>A0A0B1P747_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000834">
        <property type="protein sequence ID" value="KHJ34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P747"/>
    <dbReference type="HOGENOM" id="CLU_036943_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="29380" checksum="D48DD2A21C1799EA" modified="2015-03-04" version="1">MEIDDEPDESEKEPEIDDFPPLTSNTTLKKNADIFSSSDQTQDISSTQKDELPPQNSTLMAKARGLLNLVGPYLEEMELECPGAGSDFLALISDGVSCAVRGKKIFLKVDDPFDPQTTSARNNSWASRVAMKSIRSSNNPIRAPPTRPTPPQGQSYEDRRVMIRLDKDHESRKTEPFLLRQQIQQLLPDPSFVCDAWQAPSGITILAPTPAKAAAVLQYKDVIARRFGNAIVERQESWATFIVGPLPKLVTTMDRTEDPVDGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7N3</accession>
    <name>A0A0B1P7N3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf1754 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000741">
        <property type="protein sequence ID" value="KHJ34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7N3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7N3"/>
    <dbReference type="HOGENOM" id="CLU_098435_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="156" mass="17569" checksum="DD88C3B32CF5650B" modified="2015-03-04" version="1">MPPSEEYAPVVHGPLKLKGSGPSGIRKIKKKKKKKKAHEENGSQNQNENSSKSIVQSIPLSEPSNPNKNEGEKNISNKTHDLSLSKVDEHLDDTIDQDWAAGKTASERAFEEMRKKRLMDRIAKEGLKTHKQRVEELNKYLSNLSEHHDMPRIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7T1</accession>
    <name>A0A0B1P7T1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7T1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7T1"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="103" mass="11756" checksum="2D509F70CFCB6093" modified="2015-03-04" version="1">MAHGFDMGIAIKTTICVILGRQIPMYLCTHSHSLYECISKLGTIQEKSLKKDILWLRESYERRDITELRWITGNSNPADAMTKSKACLALQNLVDILICMRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7W5</accession>
    <name>A0A0B1P7W5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g0681</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000703">
        <property type="protein sequence ID" value="KHJ34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7W5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7W5"/>
    <dbReference type="HOGENOM" id="CLU_016864_3_0_1"/>
    <dbReference type="OMA" id="PGMPSMY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="390"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="521"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="63572" checksum="39CAB385DA61520C" modified="2015-03-04" version="1">MAWRTQGSTGSNNIPLGNKRRFGSDEQSSRREDSGFNSNHSSSRNEGYKRGRTPIKTEEPTGDDGKRRRKRNRWADATDNKAAGLMGLPTAIMANMTSEQLEAYTLHLRIEEISQKLRIDDVVPADGDRSPSPPPQYDNFGRRVNTREFRYRKRLEDERHKLIEKAMKVIPNYHPPQDYRRPTKTQEKVYVPVNDYPEINFIGLLIGPRGNTLKKMETESGAKIAIRGKGSVKEGKGRSDAAHTSNQEEDLHCLIMADTEDKVNKAKTLIHNIIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCGQIGHRKYDCPEQRNFTANIICRICGNAGHMARDCSDRQRGTDWRQTPGALPGTSAIAGSTGDAVDREYEQLMQELSGTPANGDAPRRIEAGPGAFDQPSQDDVKPWQRGPTGAAAPWQKRDDRGFESRDTTSGTSAVPWGRDRTRIDNIGEGYYGGQVGYPSSTATGTPGNAVPWNQAVSVYPPAASASVYPGYNAPGYTGGYSAQQAVGAPPGLTAPPGLSGPGLSALLQQFAGSPPPPPPTANIPPPPPGAAPPPPPPSDQPPLPPPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y1</accession>
    <name>A0A0B1P7Y1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative deoxyribonuclease tatd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001412">
        <property type="protein sequence ID" value="KHJ33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y1"/>
    <dbReference type="HOGENOM" id="CLU_031506_1_0_1"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="342" mass="37664" checksum="FDF7AADC2A26A0BE" modified="2015-03-04" version="1">MIEIKDSDNMKRVWRARFVDIGINLTDPVYQGIYNGKSRHPPDLSSVITRAQRYNCDKLIVTGSDISSSQEAVRLAREYPNICYATVGVHPCSCTNFTKGSSPPLSDPSSSSSAASVQLAQLSALASSAKASGLAVAFGEIGLDYDRLELCSKEIQIEFFERQLSIAVQVQLPLFLHSRAAHTDFMRLLSSRETDLPLRGVVHSFTGSCVEMKELTSKGWHIGVNGCSLKTSENCDVVRAIPLQYLHLETDGPWCEIRPSHAGAQVLSGIQEKILVEDGVQISDSLKWMKKEKWQDDCCVKGRNEPCTISKVAWAVAAIKGLDIKVVVEAAWENSLKMFQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P831</accession>
    <name>A0A0B1P831_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dna mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000663">
        <property type="protein sequence ID" value="KHJ34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P831"/>
    <dbReference type="STRING" id="52586.A0A0B1P831"/>
    <dbReference type="HOGENOM" id="CLU_011171_4_0_1"/>
    <dbReference type="OMA" id="YAIAQPS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058965" evidence="3">
        <location>
            <begin position="20"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="216"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="889" mass="99477" checksum="D58220CFE559EB08" modified="2015-03-04" version="1">MTIAPLPTVTICLLGSTQALTTPTSLVKELIDNALDAKATAVEIIISPNTIDRIEVRDNGNGIPREDFNALGRRGHTSKLKTFEELKFIGGVSLGFRGEALFSAVQLGKVFVTSKSEGETVATTAKLNPQGGAESLTSISHPVGTTIVVTEFLWSVPVRKQTCLKEASKTIGKIKELLRAYSLARPHVRFSLKDNRGGKVSWLYSPRRNDGIKETVSQVISRDLASQCLEKSVIFSENILFDEGNESEIVTTFSRDKSLDKKKYTVDVFLPKPTADCPKLSHGQYISVDGRPVSNEKGTIKRIITIFKHYIKSCFTEKNMRISNPFLHMKIKCPMESYDPNIEPAKDDIIFINEKILLENIEGVFKEVYGERQLIANIVGVSEKATQKNFDILLSRQVPASTPNELPLPMTEISPCYSIDHGVKLLGDLSPIRLKDGSSEIKSVSQTEKLELCRDHEEIAGTPAKSITPSKNLVSTPESANFSLSGNTLNPWIISKINQSLKKPEYKRSPPKGRSICQNLLPSPQLSSDPTMIEFEINEVQEMPVGSNEIPNTINSNSALAPTIENASGNLISPCSSLAEKDRNPKNVDTELGLFVSPDDSSSPRRCDFISARQILDPQQYPELESSKPKRLKTIKKPFISPIKKKKKIQQEDLQQTLLTDVSLISRSGTNENDQKSKEANSDLDWFMDYEHRKQEATKNFREELRMSQKSNGSPYNNRYNAATLALDANSCPDHLKAKKSISYPKIDTSLSDNDPRGYYIRRQKSFLSLVGMADGPKISRAKSLRLPLERIPVEQQLHQLLMRIRTSIEEVNKMSDSLKSIDLYVKRGNQKIPLKYGLANSDSKDKEYLIYTVRDLIEKKLKNDHNSSDLTTDNIEFKFNQYVATNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P850</accession>
    <name>A0A0B1P850_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative arm repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001372">
        <property type="protein sequence ID" value="KHJ33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P850"/>
    <dbReference type="STRING" id="52586.A0A0B1P850"/>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1077" mass="123142" checksum="78A715EDEB0D22A6" modified="2015-03-04" version="1">MAPTIEELDATVRTFYEGRGDSQKAAQIALNQFKEDPDSWLLVDKILQDATFPQTKYLGLQVLDNVIMTRWKVLPKEQCQGIRNFVVNFIIQCSSSEESLKTQRTLLNKLNLVLISVLKQEWPHNWPTFINEIISSCHTSLSICENNMAILRLLSEEVFDYSADQMTSTKTKNLKITMCAEFSSIFQLCSEVLNSATQQGLIKATLETLLRFFNWIPLGYIFETPIIDTLRTRFLEMPEFRNVTLKCLTEIGGLETGPNSTYDEKLISMFTEVLTTIANIIPLTLDLKATYNTSNARDQEFIQNLALFITNFFSAHLPLIENLPNRDFLTHAHYYLIRISQIDDREIFKICLEYWCKLVQELYNEMQSLPLTDINPLINIGATNISNPGAPNPNILANYPLRKHKYNEVLSNLRVVIIEKMVRPEEVLIVENDEGEIVREFVKESDTIQLYKTTRECLVYLTHLDVVDTENIMTEKLARQVDGSEWSWANCNTLCWAIGSISLAMNEDTEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHESHEGVQDMACDTFIKIAKQCKRHFVTLQPNETEPFIEEIVRNMRKITYDLSPQQVHTFYEACGYMIAAQPQKNAQERLISELMSYPNAAWDSIIEQAATNPSILQDAETIKVIGNVMKTNVSACSSIGSYFYPQIGKIYLDMLSMYRATSQMISEAVARDGEIAAKMPRVRGLRTIKKEILKLIETYIEKADDPEMVRTNIVPALLDAVLVDYNRNVPNARDAEVLKVMSTIITKLSSLMEDQVPTIMENVFECTLEMINKDFSEFPEHRVGFFTLLRAINLHCFPALLKLDNRQFKFVIDSCMWASKHDNREVEYAGLNMCLELITNIAETDPATSNAFFQQFFIPILQDVFFVLTDTDHKAGFKSQSMLLSRMFYFVHPADGATPKIQGPIYQPSQAPVGTSNKEFLGGFVATLLQNAFPNLQLGQIKTFVEGLFTLNKSNDRFKLNLRDFLIQLKEFSGDNAELYADEKEQQEREAKAAERARLAKVGGLLKPTELGEDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P852</accession>
    <name>A0A0B1P852_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ww domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000871">
        <property type="protein sequence ID" value="KHJ34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P852"/>
    <dbReference type="STRING" id="52586.A0A0B1P852"/>
    <dbReference type="HOGENOM" id="CLU_013872_1_0_1"/>
    <dbReference type="OMA" id="MLKSTYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="405" mass="47257" checksum="F6A71867C064ABD0" modified="2015-03-04" version="1">MLKSTYKITPPSELPSGWTEHKAPTGHTYYYNAVTKQSTYTRPSHPGYAQVPLSLIGTTENFLQEQTNPQISSYPKTLTRDKIFKVRNDYNANEQTSNKFRAPKPQPLDKPKSCQTIPGFENWKLIHTKFNRRFVYNIEKDQSFWRIPEKLKSGILILDQTRIKEKAEALNQDNGHESKDSFQGSTNSFPAFGLGGCDADASSDNEEVEVTDDELEQDITVKSHAVANQNSEKPVEFTEDDIAFQLAVMGEEYGLEPDEYGGEVDHENHGYNVDQESVTLFKDMLDEFNVNPYSPWDKIINEGILIDDIRYTALPNMKMRKKVWDEWSRDKIQFLRETRANQEKKDPRSLYTQFLLKHATPKLYWLEFKRKYRKENEMRDPGLTDKDREKMYREYINRLKLSQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8P1</accession>
    <name>A0A0B1P8P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001657">
        <property type="protein sequence ID" value="KHJ33039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8P1"/>
    <dbReference type="HOGENOM" id="CLU_1042790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="281" mass="31558" checksum="8CE01CCC1DEBC86F" modified="2015-03-04" version="1">MIRLEHDHEARKTKPFLLRQQLQSLLPNPSLVADAMQVPSGIAILAPTPAKAAEILQYKDDIERRFGKAVVERQESWTTFIVGPLPKQVTTMDEKEDPLDGLILQEPGLASIRDEIPIKRIAWKNRSKESSDLLGQVRIHIPKTKAHKFPKKLQLFGFAVGIQRIQDRKPIPTCEKCHGFHSTRTCARQPMCKMCGTESHEGSCAHPIRCLNCRGPHESTSISCPARSCRKNGAIVRPSGAQLRHIRIVGRREFIKAHPHENTQESTPTETCANDSNFTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T3</accession>
    <name>A0A0B1P8T3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000519">
        <property type="protein sequence ID" value="KHJ35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8T3"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="OMA" id="EIIVIHK"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="12"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="691"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1078" mass="124892" checksum="01926D80883D67EF" modified="2015-03-04" version="1">MSIDFPKEEEHILKIWKKIKAFETQLELSRDRPVYTFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGFHVERRFGWDTHGLPIEHEIDKKLGVSGKDAVMKFGLEKYNEECRAIVMRYSSEWRATIDRLGRWVDFDNDYKTLDVTFMESEWWIFKKIFDQGAIYQGHRVMPYSTVLTTALSNFEANQNYQEITDPAVVVSFPLLEDSNTCLLAWTTTPWTLPSNTGLAAHPDFEYIKIFDDLTGKYYILLEKLLKTLYKDPKKSKFKIVERIKGSEMLGWKYEPLFDYFYDEFKEYGFRVLNATYVTDDSGVGIVHQAPAFGEEDYNVALEYGIINERRAPPNPVDESGHFTSKVREFSGQHVKSADKAIIKYLKGKGRLIIDSQIRHSYPMCPRSDTPLIYRTVPSWFIRITDIIPKMIKNIEGSHWVPTFVKEKRFTSWIANARDWNVSRNRYWGTPIPLWVSDDLEEKICVGSIEELKELSGFKGELTDIHRDKIDHITIPSKMGKGPLKRVEEVFDCWFESGSMPYASQHYPFENKEKLESSFPGDFIAEGLDQTRGWFYTLLVLGTHLFGISPFKNCVVNGIILAEDGKKMSKRLKNYPDPTLIISKYGSDALRLYMINSPALKAEPLRFKEAGVKEVVAKVLLPLWNSYKFFEGQVALLKKSEKIDYIFDPKLEKENFNVMDRWILASCQTLLQFVNEEMDAYRLYTVVPRLLCMIDNTTNWYIRFNRKRLKGEFGVEDTKHALNTLFEVLYTLIKVLAPFIPFITENIYQRLLPHIPETLEGEDTRSVHFLRYPGVREELFDPEVERRVGRMQRVIELARVSRERRTIGLKTPLKSLIVIHSDPIYLQDIKSLETYIIEELNVRDLFLSSDEAKYNVQYSVSADWPVLGKKLKKQVQIVKKALPLLPSSEVQKYLIDGSVIVEGIKLEKGDLIVKRVLKDESSKNLETNTDNDVLIILDAELYPDLVNEGLAREIINRIQRLRKKAGLVPTDDVKMQYQILSDPEDTGLAKAFAEQSKLMERALRGPIENFNISSDEVNITENQGKGIILQEEQEIQNATFLVRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P993</accession>
    <name>A0A0B1P993_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative srf-type transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001369">
        <property type="protein sequence ID" value="KHJ33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P993"/>
    <dbReference type="STRING" id="52586.A0A0B1P993"/>
    <dbReference type="HOGENOM" id="CLU_024080_1_0_1"/>
    <dbReference type="OMA" id="LGRYQYF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="629" mass="67822" checksum="51004F72FEF181A9" modified="2015-03-04" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVIIFGSNKKLYEYSSSDLGEILTRYQYYGGANEHKGPEDFNGKDKLDDDDDDDDGSIPSHHGSVEPHMMPSQFQNQVAYQHMRHQTPSASPPISSGSAFPHPVQRKHTPQPQLPDKKPSSRNGGPRTSSNLVQQLSQPPNGFAYMSNPGIYNSQNVAMPTSHPHSLSSHMQASSMQGPPIQNHSLQGSQYANYPPPSNSHIHSHQHQMRHTYLEDQRKLTMPTAPQERLPTRPGSCPPHQVHEPSDVGIKQETVPAPQALQPVKRMSVKSRSIFTPIDESRSILSQHWASSTSKFEAPRSENPSSNNRLQSVESKNSQVGKYPAPTEGTPSQNTTSTSGSTPESLPPPSRADSASLAGGKRPILKVQIPDEPSDEGSATADSTSSPSGTNATSSQSRPNGNTTDSLSSGLVLPPPSPSAGGSLLSAGATGPPNPFARPPPIQQNPQSNGINGNGLNGNSSNGNNNGNSNQSNNSNSGNNGNNSNNGNLISSNHTIETPVSALPSRFMTNEFLPSPSSFYPEWNFRSGDGNTLPSPLNFATPVLGTGPSFLREDITNKEINKDASTKRTGNEDEMDRLDSKRIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A1</accession>
    <name>A0A0B1P9A1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cohesin loading factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001142">
        <property type="protein sequence ID" value="KHJ33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A1"/>
    <dbReference type="HOGENOM" id="CLU_006541_2_0_1"/>
    <dbReference type="OMA" id="QMVDICC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="694" mass="77218" checksum="298D043C3F5C07F6" modified="2015-03-04" version="1">MQPPLNSLQHLTPKHISEIYPISPNYQNQDVSMQRKAGNTFKSNSQIPQSKSFQREPDLGKLLISMAEEYFEAAYKLAACTTPTVTGNLDEKRLKLIATGLACLETTLKRVTGLDPRDEACIRLRYAGVLFEETENAMEAETALSKGIELCERNHYYDLKYSMYFLLAQCVAKSNLKASIKALDAYISEVETFSNISWVYAFRFLRASYSLECGTYIDNNAAIRNLKSITSLAEQRGDRPIRFVASLMVVIAYLRISGPEASQHLKSSMASVWSHQTDASCQITPLIVLAHILDLACSIREGDPQIMMNKLQAARSAMDASIRNKDWSSSDIILIPIPSSINVSRVLSPGTGMVLSIGDDGADNLIMTLLDQKGAYCLSCLLYGVVLLNRSANERIPALKYLYQGLSILEKIDESNVSKSLSNRTSQNLMARFLWKEQILCYIRIYIAFCHSLSAEWIQLKTSLEKLQKTMNNIEIPIKNQLQSLIIYLSGVCYQGSGDLDTALEIFQDSRFKLPVEKTSNISSIEQMELDIAILAGLNALLILQHPKRFDPVRNKTMLNMLEPICLSHNNQDIVNAFNLTMVTVKTNSLKTFMEIKHHLSAALNGAKKTNNSQLLSITVTLMFSTFFVGRIGNQAENGAQAASRTAAKSGNPLWMSVADNLLAQCNELHGKTEDAKAAMTLALESARRVSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9G6</accession>
    <name>A0A0B1P9G6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mrna export factor mex67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000630">
        <property type="protein sequence ID" value="KHJ34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9G6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9G6"/>
    <dbReference type="HOGENOM" id="CLU_024991_1_0_1"/>
    <dbReference type="OMA" id="YGGHEAW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="406"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="617"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="672" mass="74599" checksum="69D253A8110DCE8E" modified="2015-03-04" version="1">MPTGRLNMSRGTRNSSSSSSSRGTARGGIKKRRNGTTRVDKDGDLLMDTFTPGLGIGGNEKKRRSERGNIQLPISSRSRGSTRLKGESKVGGIRSQQAILRGPRDSQPIFLETLEVIGLKSSKASSHPDGGLESLLGFLERRASGLNAKSNMAVKIKKSWQVGDTVYITASKQDIAQILKLDNVLFAGATLSIKPHDQSRKKDEEKNEGISAEARSLREELREFLASRYNAQHKLLDLSRLGTDPRLQALGLFKDGVKNEKKLFNAIMAICEGLFKTCQDKQDAITSISLTDNSLSSLNDISTLAQTFPDIKNLDLSRNKIPNLKALDAWQWKFRSLEILIIEDNPIESHHPNLKTDLMKRYPRLHTINNLRVRSLEEVSSIIAAIEHAKNPIPIAGPIFHDLDRVGETFIRYFIPNYDNDRVALATSAYDAESTFSLSINMLAPRDKDNVVSAPNWHEYVKYSRNLSKVIYLPSRMNRLFTGAQSIQNIWTSLPKTKHPDIEIENNKYLFEGHKLPGVPDPTGQSPMGVTGIIITMHGEFQELGKSATDCVQLRSFSRTFILGPGLPGGPAIRVISDLLMLRPWAPLVSPVTVSISNISNQGHVTSAPISAKAIEEQQELIAQKFMEHTGMTLQYCLLCLQQAEWDVQKANELFNQKKASLPADAFIANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Q1</accession>
    <name>A0A0B1P9Q1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000410">
        <property type="protein sequence ID" value="KHJ35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Q1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Q1"/>
    <dbReference type="HOGENOM" id="CLU_033347_0_2_1"/>
    <dbReference type="OMA" id="IHARIDW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="47855" checksum="55F76F5788A42337" modified="2015-03-04" version="1">MTDLFSRLNLSLNAKFIGNILLRPVFYSTRVSEPLRILFCGSDEFSSASLISLKEEKTKNPGLIRSIDVLCRPAKKVGRGMKKFAEVPIKAVAQDIGFPVHETEKLDQWELPRPEGDDINLVIAVSFGLFLPARILRLVKYGGLNLHPSILPNFRGAAPIERTLMTGYGFTGVTLQTLDYKKFDHGIVIAQTKPWLKVPDLCTYARLLDIVTPIAANMLVESLNQRLFVPPLKNMGWVPQANEKLFYANKITPEDKKMPWRSKNVTDGIVRTYNALGCLWSNVYVNHQSQKRLKFNHIYLDLQFVNIYTGSVSSPNSLREKLSTSIGRPIHHIVVPTSPNQKQAVLYFENTSHKGCINFLFPCGTDREGSWSSVRVGEITIEGKKPTTAQQALKSISREGLWNLDFSNKSHASSEEYLIAYSLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W6</accession>
    <name>A0A0B1P9W6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative powdery mildew-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001265">
        <property type="protein sequence ID" value="KHJ33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W6"/>
    <dbReference type="HOGENOM" id="CLU_918874_0_0_1"/>
    <dbReference type="OMA" id="HINFLEQ"/>
    <dbReference type="OrthoDB" id="3541874at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="303" mass="34736" checksum="41460F74051AC025" modified="2015-03-04" version="1">MAERKDKHINFLEQKLTYALSAAIFMPFKGINFEANSESTSPVQSLMSTTLTTTTTTHVLTSLDPATKLEKILKHLPQQQDVVRNKMIEIILDQIEEVKQKARKELENNKILRDRLWAKEEKERERLDLVELEEMLRRLKAPPKERYSYELHPESSFNEGYQPLPEKPRQDIDGDVEMNTGLAVNAWQNTRQIKDQLAQDMLIIVRCGLRELDKYDRHCRSVLQPYESSLARRTAGPSRNNTDPKSNPKMNSMAPQATKLGSSSRIGATHDVGRLSNGMPVSMERHPASKIESLGELMRRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9X8</accession>
    <name>A0A0B1P9X8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ccch zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000555">
        <property type="protein sequence ID" value="KHJ35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9X8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9X8"/>
    <dbReference type="HOGENOM" id="CLU_028685_1_0_1"/>
    <dbReference type="OMA" id="ESWFEDY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="581" mass="63600" checksum="AFB00591554D89AF" modified="2015-03-04" version="1">MPQICKYWQQGHCKYGDTCRYDHGSSSDPRLVNDAQLRYLSTDLVEYVFDKQVIINDLTTEKPKWILSAYGPGRQAPAQLFGGFPREQSFEEIRLLHYVVSSDQQQLQQVISSVNKLIDDSEQQILYTVQNIDAAIKYLVESRKQHPNRVDICRNSRPALSSMTQSGAQSSSLISALTLDSSTPAFSVFGQPSGFGEPLVFAKLSTVGQPSVFGKPTALGQPSAFGKPSAFGQPSVFGQPSVFGKPTALGQPSAFGQPSAFGQPSAFGQPSAFGQPSVFGKPAALGQASAFGQPTSLGQKINPFAKVTSGPGPPIQSSGVLRNPQDSLASTESINKTLNPFEKAGIDSSRNQSSPNGILGNQKSSKSANLEKFESTLIVNDVQGKPSTTTKSNLSFELEPKPSFGAPTCSFKNNLSEPNSFSSRDNINKKPLSMANDSRPFSRSPRKMSDTQALPQHSNLPQLLSNHDSDFSNVIVKPPFHYSDQNLGSLNSNQNYPTKLKNKTVEYKDLMPGYKNEDGVWQRIWFPEGKPIFPQELKLPAETVYDEPTIKAYAYARKNKRFEGGKIPALPPKEEWCSFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA14</accession>
    <name>A0A0B1PA14_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative u3 snornp wd40 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001395">
        <property type="protein sequence ID" value="KHJ33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA14"/>
    <dbReference type="STRING" id="52586.A0A0B1PA14"/>
    <dbReference type="HOGENOM" id="CLU_002392_2_1_1"/>
    <dbReference type="OMA" id="MWDVELP"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="922" mass="102806" checksum="8633816ECC610805" modified="2015-03-04" version="1">MDIHRCRFVPLPPSSINALEFSHSHLKRHKLTAPLRLAIGRANGDIEIWNPLKGSWFQETVIHGGKDRSIDGLVWIQNPDEEVNGRAIIGKLRLFSIGYTSTITEWSLATGQPLRQASGNHGEIWCFAAQPVSLDHNAGQDYSQSLAAGCTDGALVLYSTQDDSLQFQKLLVRPSSKKAKIISITYQNRNIVAAGCTDSTIRICDTRNGKLIRVMSLGSGLKGGPKDIIVWAIKALRDGTIISGDSTGELKIWDGKTYTLRQRILAHKQDVLCLTTNLDGSAIFSGGMDRRTVLYRSTSKLKGRWIEVAHRRFHSHDVKAMASFEGLGMNVIVSGGHDSSPIIVPIGKYGLENHRTLPFLPQDPTLRSASKARLIISWWDREIWIWRIEKLDVQANDETSDESLPGRELVAKVFIKGEANITSADIDLEGNILVVATITEIKAFQLRPRANSKGRGYQISQVQIPSNLFGGARLLKISPNGKWLCVIQPENQILLARLAQSKFPARFMSLVTKLSRIDRQNDKLVSSGGLGSYSRVITQLAFSAHNRILVVSDLSGYVDSFVLRGTEDYSLDLDAPKTLAPTDYGIDSDTDNDNDNEADKNLNTVFGQSWIRNPLASSVPQLPATPVVLSFRPSCTPTTHGVESNLSNLDQKIAESSDTIEEDRLLVATATSNIFEIEVLKGKLSDWSRRNPPSVFPEKYRMTLETVKGIIWDISANRERVWLYSISWLWMFDLGRDFPQVKNDHPKKKLKRKRGTCGAGGEIKNSEMKIGLEGNLLNSTDERFNGANTNYIDDDDDDDNDHVEISRLPQITSEPPPPHIFNAVDLEVGEKTEISGNSQIFNNPTSTIPPITSTVSKEIRSTYHTFKYRPIVGLVTLGKTKTTKEPEIALVERPIWDAKLPPRYFGEQEWRIQEDDGSEVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA60</accession>
    <name>A0A0B1PA60_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001360">
        <property type="protein sequence ID" value="KHJ33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA60"/>
    <dbReference type="STRING" id="52586.A0A0B1PA60"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="258"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="695" mass="77532" checksum="1E5F91EEBD9F4752" modified="2015-03-04" version="1">MTESLDTAYSSVLYKPPSLLPISKYKDELLYLTETYPVTIVVGQTGSGKTTQLPKFLEQGGWCNQGKIIAVTQPRRLAATTVATRVAGEYGCELGKEVGYSIRFEDVTSSATRIKFLTDGLLLREVLVDPLLSRYNVIMIDEAHERTLSTDILLGVLKKILKRRRQNDLRVIISSATLQAEAFLRFFMENHSDSSALNSDAETSRLSSGTNLKPKQENPNNGSDYGRIICLEGRAYPVDIHYLKNPTDDYLKRAVQTVLDIHMKESKGDILVFLTGREEIEKAIESLSEQAAILGPKAQQIMPLPLYAGLPIEKQLYVFEEAPEDTRKVIFSTNIAEASVTIDGIVFVVDSGFLKLRAYNPTNGIDILTVTPISKASATQRAGRAGRTSPGKCFRLYTESDYEALPDVSSPEIQRSNLTTVILQLKALGIDNIARFDFLTPPPAELVIRALELLYSLGALDDYAKLTRPLGVRMAEIAVDPMLAKTLLSASSFNCLSEILTIAAMISLDGGVWFHHDGEKKRIETAQRKFATEEGDHLMLLNVYQAFVTIGKKEGKFCHENFINFKAMLRAVNIRAQLKRYLERFGINVDETLSSRKDKQSNSIGGLSKSEQIRRCLTTGFFAHAAKMQPDGTFRNVQGDLVLHAHPSSLMFNRKADWVIFHAVVETGNKTFIRDVTKIDRSWLVEYAPGYYKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA66</accession>
    <name>A0A0B1PA66_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sucrose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA66"/>
    <dbReference type="HOGENOM" id="CLU_151460_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="102" mass="11243" checksum="7258042FCE04DAF3" modified="2015-03-04" version="1">MSCVLQIPSLTSNYGFLERSEAKKSEEVSDTFRPTKSKSSLSRGAGVNAQYTLHVWDSQEDSHHPSLQDSHSSPRVSVVFVSTSLSPQHLFSRSPPRLAQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAA6</accession>
    <name>A0A0B1PAA6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative chalcone synthase c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001177">
        <property type="protein sequence ID" value="KHJ33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAA6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAA6"/>
    <dbReference type="HOGENOM" id="CLU_034992_1_1_1"/>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="6">
        <location>
            <begin position="240"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="468" mass="51449" checksum="2813448A41153C2E" modified="2015-03-04" version="1">MTSNTFDDINLSIIGLGSEYPPYNHEYSVLERMCAQHYPENAALDKVKMINRYTGIDNRSAVVPADHPLVNMDRPAYISELSEIFLKDGVALAVSAARKALHEAQISPFEITHMVSTTCTNSANPGYDHYVMKGLGITQPVERVLLQGIGCSGGLAAIRTAANLALAHTFRGRPARILVTAVEICSLMIRSELNSIVETGETRIGVTLFSDCASSLVLSNGLGHQRAEPIYELLGWDHRIISNSDADLRFDAHPNGWKVVLSPRVPKLACEIVKPSFDILMSSLPNLPPNYREAADFDWALHPGGSTILTGVEKELNLTPEHMRASYDIYMNHGNSSSATIISVLSRLREQDMNECAPNGKVKDFVVGCAFGPGISVETCMLKRNLNHVRRILRRAGALTPPETESEGSRSEADELDLDTRSDENDSSPLQAEFRVSDRIENNIPSNGSPSRSPENHIPEELNEFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAD3</accession>
    <name>A0A0B1PAD3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="13">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g4800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01001326">
        <property type="protein sequence ID" value="KHJ33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAD3"/>
    <dbReference type="SMR" id="A0A0B1PAD3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAD3"/>
    <dbReference type="HOGENOM" id="CLU_006038_1_1_1"/>
    <dbReference type="OMA" id="ITHDMVV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051984">
        <property type="term" value="P:positive regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180037">
        <property type="term" value="P:rapid tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="846"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="920"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="968" mass="110391" checksum="8A3AD3D3A9DC8C2A" modified="2015-03-04" version="1">MGVPALFRWLSQKYPKIVSPVIEEQPRNINGQIIPVDSRGPNPNGEEFDNLYLDMNGIVHPCSHPEDGPVPKNEDEMMVAIFKYTDRVVKMVRPRKLLMIAIDGVAPRAKMNQQRSRRFRSAKEAKEKADDREQYLKLFKSEESNNKEPEKKIVWDSNEITPGTPFMDILAASLRYWIAFKLNTDLAWANMKVIISDSTVPGEGEHKIMEFIRSQRSSPDHNPNTRHVMYGLDADLIMLGLGTHEPNFRVLREDVFSQDSKPRVCKLCNQTGHEAGECTGRSKAKDGEFDEKESAPHLKPYIWLHVSILREYLAAELCIPNQPFKFDLERALDDWVFMCFFVGNDFLPHLPSLEIRENGIDTLIAIWRDNIPTMGGYLTKDGQVDLKRAQIILQGLAIQEDAIFRRRKQIEDRREANNKRRKLEKDRDGRGRPNERLNLQESPPKNKNTTNHRHSAPSGLPIFAPGELSKEAKALTYDMVVNRGAIYKANQANKSAAAALKSKMNANIDEKNSSAFETNIENTKTTPSTSKRKASTLEHEITSQPETPQTADDEPQIDTVRLWEEGYAERYYEQKFGADPKDLNFRHKVAKAYVEGLAWVLLYYFQGCPSWDWYYPYHYAPFAADFTEISDMEISFKKGRIFLPFEQLMGVLPAGSRQAIPKEFHHLMTSPESEIIDFYPEDFEIDLNGKKWAWQGVALLPFIDSKRLLDAMAKIYPRLPSDVAARNSVGKDVLLFAENNQLLYDEVAKNFYSKKQGSRNFKLNPKICQGLSGEIEKNDTYLPHSSLISPLTSGNLPNLDNDRSITVHYQMPKLTYTHKSMLLRGASIPPPVLTLAEVETTRDKALRSGQSYGGVPLHGDGSRRKQFNYGSSKNPQYSQSYNSYGQRSFSTNYSNNFGNNPLPGLLQSWQQPASGGYVNFGRGNFSYPPPPPPSYINRPNYNPPDFGRVSTGKFRRQNTGPRQYEPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAL3</accession>
    <name>A0A0B1PAL3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="JNVN01001100">
        <property type="protein sequence ID" value="KHJ34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAL3"/>
    <dbReference type="HOGENOM" id="CLU_089358_2_2_1"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="17964" checksum="A7613ED82603B7F8" modified="2015-03-04" version="1">MTSQELDVPVSVKGPGVFPPLDGARLRIAIVHARWNTPIIGALVAGAKSSLLATGVYEQNIDIHSVPGSWELPIACSKICSSYPFPDALIAIGVLIKGETMHFEYIANSVSQGLMKVQLEKNVPIIFGLLTVLNQEQAEIRAGLKNGGHNHGEDWGKTAVELGIMGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT7</accession>
    <name>A0A0B1PAT7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 3-oxo-5-alpha-steroid 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001062">
        <property type="protein sequence ID" value="KHJ34091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAT7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAT7"/>
    <dbReference type="HOGENOM" id="CLU_065395_0_0_1"/>
    <dbReference type="OMA" id="PHYALEW"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="251"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="335" mass="37998" checksum="DEB7BD997123E73E" modified="2015-03-04" version="1">MSPMPSNLYPISRELWEQVVTIFQYFPLVAAIQLFVSYYPAGKTSIESRLNLPGKQAWISMEVPGFMVVLYCLVSIPSKNAEITSSISECVTFAWNNLPIENIILAALFVIHYIYRAIIGPLLNPSMSPIHISIWISAIIFQLMNGISIGGFLAGYGPAITADMTKSAILPGSNKSQVDWLQIASRWRRELGIFIWALGFATNIYHDEVLRDIRRPIKKEGVNPEEAEKHKIGSLGQEKIGKQISGKEKHCVNKLYKIPQKGLFQFILFPHYLCEWIEWSGWWIAGGSLFFPARTFLINEITTMLPRAIQGRNWYIERFGKEHLAGRRAIIPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB49</accession>
    <name>A0A0B1PB49_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000208">
        <property type="protein sequence ID" value="KHJ35912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB49"/>
    <dbReference type="STRING" id="52586.A0A0B1PB49"/>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="114"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="62857" checksum="8CFADC0B95A11C5B" modified="2015-03-04" version="1">MASTLTIVKSFNDTDDKENIVNPSQRYLSTRGGSHGLSFENTVLKGLASDGGLFIPEEIPYLPQDWESKWENISFLDLAFEILSLYISPSEVPTSDLRDIISRSYSSFRVPDITPLVTLDEQKKLHLLELFHGPTFAFKDVALQFLGNLFEYFITRKNRGKQGKERYHLTVVGATSGDTGSAAIYGLRGKKDVSVFILYPKDRVSPIQEAQMTTVLDPNVHNLAVQGTFDDCQDIVKALFADSEINKNLDLGAVNSINWARILAQITYYFQAYFLLKNSHVFKSGDKIRFVVPTGNFGDILAGYYAKRMGLPIDKLVIATNENDILDRFWKSGKYEKMVVSSANAQGGIPSDGAKAHEGGVKETLSPAMDILVSSNFERLLWLMVYESKPKTQNCDDDIKKHACSDVKVWLEALKINGGFQVPDNILNIAKKDFESQKISDPQTLETIKDFYSPATKNQDRKSYILDPHSAIGIAASLLSIECNSTNEIHHIALATAHPAKFAHAVEMALQHEKDFDFKSVLPLQFVGLEEKEKRVQIVPRDAELESIRTIIEQGIQAELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBA0</accession>
    <name>A0A0B1PBA0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative rrm domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000366">
        <property type="protein sequence ID" value="KHJ35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBA0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBA0"/>
    <dbReference type="HOGENOM" id="CLU_017928_1_0_1"/>
    <dbReference type="OMA" id="ITYDSHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000007">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000647">
        <property type="entry name" value="CCCH zinc finger and RRM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="359"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="471"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="791" mass="88422" checksum="7CC82B31A31E9670" modified="2015-03-04" version="1">MLFIEEDAPLLKKWIVKRLENTSDADADVLADYVLALLRHDGDDETVRALCESEIPDFLKEDSVLFVRDVFDAINYKKYLPSAKNSRKISAPFDPPTGPSALQVRNHVSNYLNGNSNSNKKRSYNDRIDSQVYERGYVGGNHHESNKFQRRAGPQLGTDLAEANKGGEYNQNLQPYMGLPNILSQYSGIQESMPNSSPKVPTFDPIDPVTAMIAMQALTFPIPGTNPFGQIGFTAHNDPNMSLNKQRCRDYDVKGFCARGITCKFEHGENPLWNPSQSQILSEEYDPSNSIMTSVDLNGAGKSSKSEGVSDNTQIVVDSEGRRKSKARRGELRQTGNSNRRGGRSEFSSDRPNFDKTKTTIVVENIPEENFNEDNVRSFFTQFGTIVEISLYQYKRLAILKYDSWNSANLAYKSPKVIFDNRFVKVYWFDEHDPQLKNKDDSISGTINQKITGAPIPARETSEPKIDLEEFARKQQEAQELHIEKQKKRKEMEAAKKELEIRQEELLKCQAEEKRKLMERIAAKERNRETTLGLEADSLGSTDKSSSQTEALKAQLAALEAEAQLLGIDTSLSETNGWSPRGRGRGRGRGRIYSGHRGRGGYRGRGAAPFVLAGSLPDPRSFNLDNRPKKIGLTGVDFSDPEKDENLKQYLLVSNKYHQLFVVISLDPFCTKKLKGIGEYEDIEVTPSRTIITFKDRRTAESFMFGSIGGEIPSVGKVEMSWISTLNPSHALSRQADTIKSGPERGGDAAASATGTSQGTDMVLSFKAGNQQNTNANMDYDVAYENEWGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB6</accession>
    <name>A0A0B1PBB6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB6"/>
    <dbReference type="HOGENOM" id="CLU_033319_3_0_1"/>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="27449" checksum="7D40CF0D60FEE14E" modified="2015-03-04" version="1">MKPPTKERDRSHFFAADFESDGKKHLLLCASGSVATIKIPEILQSLSKHSNLSIRLVFTKAALHFLNYSSNEGFHLGIFESIPNVDGIFLDNDEWNQPWNQGGILHIELRRWADIMLIAPLSANTLAKIVAGMADNLLTSVVRAWDTEGLIQNSGERKRIIVAPAMNTAMWNHPITKVQLKVLGHDWAISEKNDIDMDINKGTCHGWFELLMPVEKKLACGDIGIGAMCEWRDIVKIVEKRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBJ2</accession>
    <name>A0A0B1PBJ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBJ2"/>
    <dbReference type="HOGENOM" id="CLU_2814336_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="67" mass="7606" checksum="318B8613EE4823A3" modified="2015-03-04" version="1">MLRGIIAAVSSIIDFCPEMLPGSTFLNFEVLRTDLLFSTPFWTPKNSNEQVLGAVISRQNRLFSRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBL3</accession>
    <name>A0A0B1PBL3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBL3"/>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="33100" checksum="7671F1605B48FA6D" modified="2015-03-04" version="1">MTAEISTSHSDPQPLLTAQSQEHVVNSDSESNENKSSKIAVMKAKERMERFRELQARAKVGSQKNLREVTLESQRLATDPTLVASLNRKSAIASHNLLKSDIEDAGEDFERKRAWDWTIEESERWDKRLKKKEAHRDNQAFQDYRQESLKVYKRQIGNLKLDMDHYEKEKMAAVEKAAASGALEIVEIENGELVAIDKDGTFYSSTDSTSFVDHKPPKAAIDRLVLDLQQAEEVRLRKRRDRMAQNGEDGDVTYINEKNKQFNQKLSRFYNKYTVEIRDSFERGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBP0</accession>
    <name>A0A0B1PBP0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 3-methylcrotonyl-carboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001066">
        <property type="protein sequence ID" value="KHJ34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBP0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBP0"/>
    <dbReference type="HOGENOM" id="CLU_000395_3_0_1"/>
    <dbReference type="OMA" id="FINKPKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="28"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="144"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="655" mass="73741" checksum="5A9D45AD741D60D8" modified="2015-03-04" version="1">MLFRIYKFPASWLRPCHIRTISSASVKPINSVLIANRGEIAIRVGRTASKLGIRCTTVYTESDLKSQHALHSPLNANLGHISAYLDGEQIISIAKERNCEALHPGYGFLSENSEFARRCIEEGLVFIGPSWEAIEAMGNKSRSKEIMINACVPCIPGYHGSNQDPEFLLNEAKKIGFPLMIKAVKGGGGKGMRVVFYENEFLEKLNSAKSEGINSFGDDVMLIEKYIASPRHIEVQIFGDKHGNVVTLGERDCSIQRRHQKILEEAPAPNLAEDTRQKLWEKARLAALAVKYHGAGTVEFIYDNDTGTFYFMEMNTRLQVEHPVTEFVTGEDLVEWQFRVAAGESLPKDQDTISNNLKYRGWAIESRIYAENPERNFSPDSGRIRYLRIPKISDHVRLDTGFIEGDTISPAYDGMLAKLIVSAPTRKLAIKRLFTSLQEYEIVGVSTNIEFLKKICQSRAFIEGEVGTNFIQENKDQIFAPSLIGPEVYVQAAIRLLTCKTSKASLSKPIPHGLDVGFKNFIEREINFLTFTGNKENNTRVVLKSIKNNCYTFELNINGAIKVFENVVFECRDFTISSFFSHTRIDSTVILHDNTITVFQQGQKIELNIALPDWANKVLDHKDHLNSVLAPMPCKILRLVVREGDKVDENDPLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBR0</accession>
    <name>A0A0B1PBR0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001055">
        <property type="protein sequence ID" value="KHJ34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBR0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBR0"/>
    <dbReference type="HOGENOM" id="CLU_010862_2_0_1"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="732" mass="81760" checksum="B48C092E96B17970" modified="2015-03-04" version="1">MRLWSQVLLGRSSEKLSKFKICSARKKFSYSTAMDVTAAPAIDQCIEYEGRRYTTLKEGLAYILIPADNSKVPQQSPLENSKPQDVFYNPIQQFNRDLSVLAIKAYGEQVVEVQKKKEKHSNLTKIRAKEKRCNKRKNHHDELLENLSTKKSCLPDITSPRTDNVKEEPNIALPTIEKNGSPIQPLTEARDDERIALVVPESSTSQDDGNCCLEREKIKDLKSDESNKAPSYVPHFTILDALSATGLRALRYAHEIPFVTSITANDLLPSATKQIKLNILHNRISSKIIVTNGNAISHMYNLIDSNKTSNLCTKPSKYNVIDLDPYGTASPFLDAAVQAVQDGGLLCVTCTDAAVWASNGWPEKCFALYGGLPLKGPLSHEAGLRLILHAIATSAARYGLAITPLLSLSIDFYARIFVRVYKSAQHVKFLAGKTMIVYNCDTGCGAWTTQMLGRNRFATSKKGNEMWKHGLEQGPSTNQNCAECGFKTHIGGPMYAGPLHDPDFVQRILDSIKDVDKETYQTIPRIQGMLTVALEECLSPSHMNENQSNPTDTQKKDVSSSALPNSVNDSHFTTDHTTIDPAPFLFMLPMLSKVLHTITPHENAIRGALRHLGYRATRSHTKGGCIKTDAPWKEIWRIMRAWVDERAPIKEGTIRENTAGWAILGLGLKEEEKKSKDLESLVHKTEIVSDHSNKIVFDETLGADKDRNRLVRYQRNPRENWGPMARAKGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY6</accession>
    <name>A0A0B1PBY6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wh1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000111">
        <property type="protein sequence ID" value="KHJ36207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY6"/>
    <dbReference type="HOGENOM" id="CLU_015385_1_1_1"/>
    <dbReference type="OMA" id="EYNQDRK"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="704" mass="75733" checksum="203C8404713871DB" modified="2015-03-04" version="1">MPSILTDEEKEIVRRQVPKASNKIQAIAAARLYIAYPDRNKWTNTGYQGVIVLANDLVGNTFWLKLVDTSPQNRGILWDQEIYDTWNYSQDRTFFHTFEIEECLAGLSFVDEKEAKTFLKKMNDREKNASKATKAKLFGGISVPVGGTGFRHGILGGFFGGYRHSSASSIQPTPPESPSFSLSPTHKKEYSEPSKTKDDSDFTALYAIDPNWRENWGDDLKSLGITDDLIRENQDFIADYIKAPKVDQIHSSTNVIKNQRIRSPPPPPQNLAPSSASGRGRGTPPAPPPARRTAVKVDLHREPTPPRDSSPLNTSLSQRFAAPPPLPDAGKLAHIPNQQVPKVRISTQSNQSPRPPPRPPKNSKENSESGVSKFNVPPPFSGEKNTGSFISHRAGPLIPPRETIPPLTRVFHTSSSQVTTPLAKSEHLPPPQLPPKIPIVSASATPPLPPSSLRPSVQITTRDCEKNREPNSPQPQSFTVSQIPKNPSVSPAPSPTSLRVTQTSSLPLLPVHQAQSSPSLIAAQEPSSLPPPLPISRASPPSPPPPPPPPPPPPPLSQAQSPVNEPVSFTSPIPPPPPPPPPPAPVLQTDMGSSTFPAALKSHSNCGTSHLIENTSLPHVGDRSNLLAGIQKAGGIGCLKKVDPSKIRDRSQALVPGSSEHKSSSNEGVSLGADGGLAGALAAALNNRKKKVSASDDEAEDDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC00</accession>
    <name>A0A0B1PC00_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000275">
        <property type="protein sequence ID" value="KHJ35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC00"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="21885" checksum="A634420C1D223128" modified="2015-03-04" version="1">MTDSMDITQENQVLSTDTSNKPPPIPPIPTIPNPLPPIAPPTPPSNSQLLNSTTSSRKILKPAIPIKLPIPERPQQNNKDRSDTANAFLPLELAEVVATRRRRERAWNARIMICTTVYSNIESTLANFSDEIQKEEVIAFKAYLRQAIANFAAVDNSPNSPNPPKIPSHSKPTKICGSGSGRSKNVEKNVPVAQVPVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE4</accession>
    <name>A0A0B1PCE4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000561">
        <property type="protein sequence ID" value="KHJ35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE4"/>
    <dbReference type="HOGENOM" id="CLU_594742_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF27">
        <property type="entry name" value="OS08G0421700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="322"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="460" mass="52172" checksum="CF63A24D428A4B9B" modified="2015-03-04" version="1">MSTNAVVILGNQKANLPILVGQSNFRRWYKSWHIALRGAKLWTVVSDGDDKEVRPIKRKDETNDEYKMRLERYNDRNDVAHSAILSGVSDDLQELVCSCDEELESARVAMRLLKDKYDYETTTSTIQLFKEFSELKMAEGDSISHHITQFETAYSHIYSRCSGSTRPEAIALRNFLSVEQVKVMYLFLSLPASYNNIIDNLTTKETLRFADVNRRLLDLNSIKPLDVPSSSKAYFGNGKPINDNKILECTYCKKHGGKYMGHIHNNCRKLQKHLDQKSKNKSQSIPQRNKANAVMIPDEDLFDVILNDKAFLTCSTNSSSSWILDSGCFAHMTSRKELLSPLNHHKGVVTIANGRQIPVEGKGNLSLNLRTSTGGEISVTIRNVLYVPELKGGNLISESQLELDGNLIISQNGRRRVLFKNKEWMYAVLDSSKQFIVQENNNKTLFTSYHEAHECFGHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCG0</accession>
    <name>A0A0B1PCG0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g0842</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000946">
        <property type="protein sequence ID" value="KHJ34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCG0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCG0"/>
    <dbReference type="HOGENOM" id="CLU_030988_6_0_1"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="185" mass="21232" checksum="88D9F0DD5A7174B8" modified="2015-03-04" version="1">MLKIWSLKQQQQKDENENTATRSKKKKVTAAQLRAQKDLSELSLPSNMFTEFPDPDDTLNFKLTIMPDEGMYKGGRFQFTFSISQNFPHEAPKVKCIEKIYHPNIDLDGNVCLNILREDWKPVLNLQSVVVGLQFLFLEPNSSDPLNKEAAEDLRNHREIFKRNVRNSMAGGTIKGQTFDCVLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM7</accession>
    <name>A0A0B1PCM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mfs maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g3795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000165">
        <property type="protein sequence ID" value="KHJ36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCM7"/>
    <dbReference type="HOGENOM" id="CLU_855792_0_0_1"/>
    <dbReference type="OMA" id="TIMISYI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="35764" checksum="D09DAC4E20D7F3E2" modified="2015-03-04" version="1">MNSNSCLEMTAKNDLSVHAATPKQGADANPASCLEPGQASVNHDATRAKTRAEKLEREMSVTASWKLWRPASYWSILLSLVVIMEGYANLLLAQFYAMPAFCQRYGVIGPHGTYEIPTLWQAGLSIGCLAGETAGLCTSAIAVDRLGYRKTMIISLLALVAFINIIFFSQSLVVLLIGEILCGVPLGVFQTLSCTYASDVCPMKLRPFLTTYTNLCWLIGQLLSSGVLRMLVGRSDQWSYRIALALQWACPLPVAIAIFFAPESPWWLVRHGRKEEARKALTRLTNSKDQPSAFSVDDTLSMVSLFDDFFSPFSPRETFGISPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCS4</accession>
    <name>A0A0B1PCS4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCS4"/>
    <dbReference type="HOGENOM" id="CLU_068316_1_0_1"/>
    <dbReference type="OMA" id="RRENECK"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="35889" checksum="74A9BFE41B538A27" modified="2015-03-04" version="1">MPSKEATSYFSPTITQWTDRPMSRFSMASETATFYSALDSPLSPNKSSHAITSPDCTDLDSHAGENKLWKEMSGRENDSPKLLRQDSGYAAHTSNTVSPLKVPLPKLRSKPKRSTKSQTRCKNWRSTTTRSSLSPPHHSQLNIEDCQIKSHRQRPCNNNKKPKYLLERRYFSELSIFTLSGLDTDKSLSSGESSSPSSPLPFPPTINYWTSDDSRRLEYAAIDAASKGVRGFFVRIVPDFMLPPQIRRTKFWGLESEGRQREGSVRRYRLALPEDLVDKSAKKKDQNYLGSLNKERKGNRPGILRRWSTGLKINRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD13</accession>
    <name>A0A0B1PD13_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000469">
        <property type="protein sequence ID" value="KHJ35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD13"/>
    <dbReference type="STRING" id="52586.A0A0B1PD13"/>
    <dbReference type="HOGENOM" id="CLU_638087_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="292"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="48219" checksum="BF564686CBA27DD0" modified="2015-03-04" version="1">MTQLNSSTLKSHLQGTLYLTNISPIFATPFTSLQSQPHQVIRKQPPYLKDSVECSASATIQTQQKTETAYTFQNTAPKKYEAARIDWNQGESNRRQRLSLWNPQNFTPRNVASRERILDDSNDTSDHSGLKGSVISTEANSSFINVSEIEGSLQSDFEPTYKYKKVSLDNSENLVTAAVDGGWDLPFATSLYPLSEYTANIRNMVDLESGLRPQYSETSNSTPVLQYANQSERSTPAGLGSMPTPTLSDSSSIIGSEMVGNNQEEWGPQHPCYPHLNPHVPLSSPLFGSTRIIRIQRDWMLQGDLAPTFSNLYPEVLDTAGVTEQEFRNLLENLNKELIPAFNPLGFRNIFDGIMSVLTGWLWEDAGLADIKEKLRRVEKLLEDWNKKMEKKLMSRPETGAIPKALPLRRTGYMTLDIQVPNPEISSSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD34</accession>
    <name>A0A0B1PD34_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000123">
        <property type="protein sequence ID" value="KHJ36168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD34"/>
    <dbReference type="HOGENOM" id="CLU_1972102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="127" mass="14214" checksum="0D324B7D6DDFCF32" modified="2015-03-04" version="1">MSDNEGKVALGQRVSLYKWIADLQSALARRHCTGHVFHDINGIKAIIAPTLPERGPSSNEAYKVAVGEYETEMQKFQEGEIEARSVLASRIERSICPPSLMTMSSKSIYEYVLVPRITLSERKVMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD5</accession>
    <name>A0A0B1PDD5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative zinc knuckle transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDD5"/>
    <dbReference type="HOGENOM" id="CLU_024213_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="450" mass="51076" checksum="589C3D282BCC346A" modified="2015-03-04" version="1">MSWDFPTAADAHASEWETQDFDTYGGTEDKNNGKNCEEQGYAEGGGDGDYGGGGDGEWYGCEETGENCQNQTPREFTGNCRICDEQGHRANECPNKPATICRNCQEEGHEAFGCTRPRKINRDHIQDKTVEEAWKLINDAVEERDLDDLKDAIEIYIKAEPETTYQQLEKKFRDSDMGVYIIALEKELATTYTNMDFQGCLDKTYSITWRWSPKPMRPKEIPSWPNTPEENFERLADAGEPTDRGIPKCSNCNTLGHTRRRCPEQIVENPERTTVLCFNCNKTGHRMRDCPDPRVDRLAEHKNEDSGENALTCRNCDAEGHISKECPLPRDYSRIKCQNCEQMGHTKVRCTEPLKEAEYGDGDYAYGANTGSNEGQDQNYSGGYGADGWDTQAGDQGWDKPNNQSWDKPSNQGWDNPNNQSWDKPSNQGWDKPNNQSWDKPTSTLNNSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDY6</accession>
    <name>A0A0B1PDY6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000677">
        <property type="protein sequence ID" value="KHJ34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDY6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDY6"/>
    <dbReference type="HOGENOM" id="CLU_725652_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="433" mass="49605" checksum="C89B94C3EFC2F8E1" modified="2015-03-04" version="1">MWLKKAQEIMSNVATNYGLSRLRFGVTISIFGLGLSIYASSQFITREIISCSIFYIIVFLHGITMFGSSYVEEEQSFWYWATSAWLGCLLIKYSREKKMSKYLMFLGLVLVRTAMRWNQTGNKFAGQPDIAKSFLLKHYRMLWLLVMISYLWNLFSLQSQRHNYLQSTVFDIITILISSAALSLKIALIDEDSPEIISDSLRSIANLSLGLSTVFRVRLIFFIMSVLLYFTIRLRLKHKITSYQTAYIIHKILICILYTQSRVENIPLLLTFELLFMLLDKLNLSVIEVTITNILLQHTSFFALGGSNAISSIDLSNAYNGVDNFNVIVVGVLTFISNWAGPILWTSASNLMLLRIPRIRKRNIFLSHVALLTVFLTCSLSFTMVACILLRTHLFVWTVFSPKFLYSLAWSLGQHLCVNLVFGGLLYWVGTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE21</accession>
    <name>A0A0B1PE21_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000636">
        <property type="protein sequence ID" value="KHJ34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE21"/>
    <dbReference type="HOGENOM" id="CLU_2147735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="112" mass="12878" checksum="4D87F56A6D887EAD" modified="2015-03-04" version="1">MNGEEHDNVGLIFDFWHETLCHPAESSFEKTKPLTINSNILKVPKDFNFQAYSSSKSTHIKPKSVGIIKSEKRTDFILISVDPFQCFNTVMLGITYHSNTFNPSEDYVMYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE23</accession>
    <name>A0A0B1PE23_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4519</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE23"/>
    <dbReference type="STRING" id="52586.A0A0B1PE23"/>
    <dbReference type="HOGENOM" id="CLU_004372_3_1_1"/>
    <dbReference type="OMA" id="RGSWDGD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="27"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="740"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1047" mass="113588" checksum="28164F6A0E58FF7C" modified="2015-03-04" version="1">MKIIRPAWLMHSGEQKDFEVYSCHVSPDGYRLATAAGDGYVRIWSIEAILQAGDPNCSKPKQLCHMSYHSGTIHTVRFSLNGRYLASGADDKIICIYHLDANPPAHSASLGTNDSPPAENWKITKRLIGHENDVQDLGWAYDSSILVSVGLDSKIVVWSGHTLEKLKTISNHQSHVKGISFDPANKYFATASDDRSIKIFRFNPPSASATAYDSLNNFVLEHTIVAPFVSSPLTTYFRRCSWSPDGNHIAAANAVNGPVSSVAIINRGQWDSDINLIGHEGPTEVCTFSPRLLSKKEISADGTNNNYSLQSFVTVIACAGQDKTLSIWNTSSSRPLMVCHDLAGKSISDLAWTPDGLSIFASSLDGSIVALNFEKGEIGHIAPWSENDKALQKYGSGRRGAGIIEDVIGLRLEEKSKAGELKGAEGRMGALMGDANSVSTSTQDKSSDTLTPMTGVDPSHSAPTNGLGPKETPASAPVDINAAKLEALKQRVTITKDGKKRVAPLLVSSSGTGLSSLPQSQLMAASSKNTPIDTPDSVLDLSKPYDGLPRGGLAAMLLGNKRKPVTFEENEDEHLTYKKPGLSSGPVAILVNGETGAENALPAPPITGIQTTPEFIRPAVMNPILSVSQTRLAVPKIRSHIVRSLDRGTLPLSKSNDNTTNGTNGIEGLAKMEDDIILEVQNPTTLPSQIKDPSRITTMKRGSILWQDYLPRAVILVTGNKNFWAAACEDGTIYTWTPAGRRLLNGLVLEAQPVIIECREFWLLVITAVGMCYVWNVKSVSSPHPPVSLGPILEIAMHTLGTHTTSAPGITSAHLNSSGQIIVTLSNGDGYLYSQNLCVWQRLSEAWWAAGSQYWNTNDSAMSSLTSKAVGQDSRRSSNIKSTNLSAGIIPHLERHTTSEVLLKGRAYTLQRLIKSLLAKEGFENFESGISIAHLENRVAAALQLGAKDEFRIYLLMYAKRLGAEGLKAKIEELLRNIMGGILHGNRTSSEIRGQGWMSEDGLLCSWDRKEILKEVVLILGRFRDLQRITVQYAKVLGMVEEDCDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE66</accession>
    <name>A0A0B1PE66_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000481">
        <property type="protein sequence ID" value="KHJ35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE66"/>
    <dbReference type="STRING" id="52586.A0A0B1PE66"/>
    <dbReference type="HOGENOM" id="CLU_030571_4_0_1"/>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="36082" checksum="C7627A7E3E035435" modified="2015-03-04" version="1">MNSLLNKNRLFFRLHPLSTRLIQASNMHIQSIPMWKGSGDNYAYLVIDDKSNEAVIIDPAHPDEVMPILKEKINNAQINVKAIINTHCHRDHAGGNNIMKIQPEFKEIPIIGGKDCESVQITPKNGHSFKVGNINITALYTPCHTRDSICWVMEDEKQRAVFTGDTLFHGGCGRFFQGTAAEMNLALNKTLASLPDNTTVYPGHEYTKSNANFAISVLKDKFTTNLWKFAQENEETQGKFTIADEKRHNLFMRVNDPEVQKVIGTSNPIEVMSKLRDMKNNFSKPNQHLTICANSLLSSEVLCESIEPFTLYSLGQSWGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEE3</accession>
    <name>A0A0B1PEE3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEE3"/>
    <dbReference type="STRING" id="52586.A0A0B1PEE3"/>
    <dbReference type="HOGENOM" id="CLU_2051394_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="120" mass="13782" checksum="8B65A10D86454037" modified="2015-03-04" version="1">MLSSTSNILDQTQARVNELERELASKLGTKDPENLKEILAEFIKSIHPTDSIIKRSAKVPDPPVYTGNKKEFFSWMSSILLKLNVNEDHFPSDQIKMAYIHIYIYIQDWTHLVKHISIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEK5</accession>
    <name>A0A0B1PEK5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01000543">
        <property type="protein sequence ID" value="KHJ35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEK5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEK5"/>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="OMA" id="AAFKHSW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="435"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="689" mass="78675" checksum="47E6A27C771C4DEA" modified="2015-03-04" version="1">MSTFSIPQNVPSFSEPRRESENRAWGASGVNSRSGISPRNGIFGGIQERMGGVFEKNRVLPMYKDKPFTYIPSRRQRRTWRQRWVFGTGVLLFMLLTYLWWLSWNRKNLDMGNSKGIWNWLSKPEHNESEVNWLERRERVKEAFVLSWDAYDRHAWGYDEFHPVSKKGRQMTPNGLGWIIVDALDTMILMNLTSQLTHAREWLKTSLNYDQNQDVNTFETTIRMLGGLLSAHYLSNKFPDMAPITDDDEGNAGEDLYLEKAKDLADRIIGAFDSPSGIPFASVNLKTSKGLPSHEDGGASSTAEAATLQLEFKYLAKLTGEAFYWQAAEKVIKVIDDNIAQDGLVPIYISADIGHFRGENIRLGSRGDSYYEYLIKQYLQTSKEEPIYNEMWNEALQGVRKHLITYSKPSRFTILGERPNGLNGNLHPKIDHLVCFMPGTIALAVTGGISESEAKKLSSWNSQKEEDMRLAQELIFTCWGMYKVMATGLAPEIVHFNIENPPLPLSAPHNPPSELINSKDAEWKKDFVVKSNDRHNLQRPETVESLFYLWRITGDLKYREWGWEMFNSFMAHTAINGGLDGFTSLSDADVIPPITRDNMESFWLAETLKYFYLLFSPNDLLPLDQVVFNTEAHPFPRFKMGPLFKTGWTRIPRDPKGRVVPNSMHELVNMVPVESQSLDLNIATSASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFC8</accession>
    <name>A0A0B1PFC8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000333">
        <property type="protein sequence ID" value="KHJ35601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PFC8"/>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1961"/>
            <end position="2540"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="3066"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1758"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1761"/>
            <end position="1777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="3196" mass="361567" checksum="D298263EE295E593" modified="2015-03-04" version="1">MLEGLVASLLNRFLGLYIQNFDPKQLNVGIWSGDVKLRNLELRREALDQLKLPINVVKGHLGELTLRIPWSNLRGQPVQIHIKDVYVLAAPKENTEWNEEEEEKRIQALKIKKLESTDILKEPTQESLSQEEQQKNQSFTESLVTKIVDNIHTTIMNIHIRYEDTISNPSHPFAIGVTLQEFSAVSTDGEWNPTFIQDFIGSTQKLITLGALAIYWNTDTKLIEISREDEISNSITGSSEDVLEKFKSMIAEGYNLSTVNHQFILKPVNGLAKIQMNKPRRTGLPQINAKLVFDEIGMVFDENQYRDALMMVDLFHYFNLNQEFRKLRPRNSTPKEDPRAWLIFACHSILGKIHDRNRRWSWEYFKERRDDRLRYIELFKKKKKQIVALTIDEQSELSNLEWKLDFDDLRFWRSLARNQLKKENAVIKKTNTAKKNQGWVSWVWGSKSGDEGEDPESMITEEQKKELYDAIDWDEKSALANTIDLPKETIKIQVSASLNTGSFTLKRDTHRQETEVLSLYFDGFSAKYQQRPESFLADISLEGLRVNDGTVPDSLFTQIVRVKDAPNIPAQKMQLTEVIETEDSIDPFFQIKFEKNPLDGNSDIVLIGKLKPLEIIWNPEFIVGIVKFFRPPERHMDSIEAFIESAGATVESLRKQTRAGLEFALEEHKTLNAILDLHAPLIIIPESITEEKGACLILDAGHISVTSQIVDKNTLKQVQEKQSHSYSVEDYHQLRSLMYDKFLVKLSSAQLLIGPSLEETKIQIYERNESTSMHIVEKTNIDFMVETSIIPKAPNLAKMRVSGRLPLLHISASDKKYKSLMRIIDVIIPKFVDTENQNSLNEKKNVTSKSRNQINILKFGDSPKNFEYSEFQPDMQDTIINQASSIEDPKITDTAKEEVNETLKLQQHNFELSFEVDRLQGSLFRSGIDEYSPDQLLVELVAENYSLKLLVRPFDVKVNTSLRSLTVDDHVEEISDEFQSIISSGDISTGDVRELISVSIIVVNKESPEFLQEWEGVNVNIKVAISTINLIVTRKTLLTLLDFILVTFTTNDSSLPNSRKQLKQSENQVPISESVSVEKTEAMVVRIKVDLQSIRMILNNDGTRLATLSLSNTDVGISVMSNTLRIETKVADLTLLDDMNKDSSEDSSMRKLITIQGDDLADFRYETFDPEAGDAYPGYDSSIYLRAGSIKLNFIEEPIHNIIGFLIKFGKMQAIFNAARQAAANQASQIQQNADRMKVDIHIKTPIVVFPRSSAPRPDTITAHLGEIYAENKFISLSDTEFSTTAMKISTGVRNIRLTSNFYFSDDRNEEIELIDRVDLDFIMTYSQHIEGSQRPELEIEGKMTDINLCITQSQLNFIFKIMKSFPTIFVVDDEVLERDVNQDNFKDKAKLDVKSEPSDVSHNTLVDLGPELRLNSQNWTKLDLTFHVDTIGLELILANENEPTYDLEAASLSRFSLDNTRAKFRLTANGSIDSELLVHSMTIQDSRAKIINKFRKIMTSTNNNVQQFMASITISGGVERSIIAIMAVDSPRIIFALDYIFALQLFFNKGLAIDDFNSTGRQKSTSDLNDSSDSGSKKITKIENLTSKSSKSFIKDGAISIEASENKPFASFAFRVNIIDAQLILIANPVDINSEAIVLGAKQMLMSQQNSFTLQISEMGMYLCRMDHFEDIRLRIIDDFSAYISLDSSNLSSTNVEISLEPLVLRLSLRDILLALQIIGKASELSGTQDKSKSFSGACESSKQSKSSEVARTVCTETALKNNSPKPKSSVSLSNPTKNIPNGKEISKRQELIANLQGIRLVLIGDLYELPILDLSVKRFTVIVNNWSSNLRASATIEMFTNMYNFSKSAWEPFMEPWQVDFLISKKINPDSISVDLKSSKILELTVSSAMIALASKSAQFLTQKYDLLSKSRGVDAPYRIRNYTGYDLTVWADYNGHEKNDQLKINFKDGEEGPWRFQDWETERENISSDASNGIVGITLEGSGFSSISKISINREGEYLFCLQPRKDQVLHRILAEIKLGTNNVKYVTFRSPLSIENKSLIPVEMGVLDEQDGHLNRIEKILPGESRPAPVGYVYTNSLLVRPSQGFGYTWSTEKLWWKELIITPTKTLTCESEQDAEIHPFYFQMHASIDKSNPLTKIYPYMKIKISPPIELENLLPYDFNYRIYDKNAKKDWKNFLRKSGVTPIHVVELSHLLLMSIEMHDTPFKASEFSVINPGNNDDFRRETTLICKDNEGLTLNLRLHYFTIPNSGGAFRVTIYSPYIILNKTGLYTQIKAKSLLSQPKPTAGEGFYRNLAKSGRQKALPYLFAFSGDDQRHRAIIKVGESSWSRPQSFDAIGSSTEIILPSASNNTEIHVGITVKAGEGKFKLTKVVSIAPRFILKNQMIEEISVREPGSSEIMIIEPGALQPLYFLQKGNKKQLSLCHTGLNNKWSSPFNISDLGTTYVKIAKQGERQNLVRVEVLLESSTVFLHLSMETNHWPFSIRNESDTEFMFFQANPNFDDGDYDNNDRTGWRPIRYKLPPRSIMPYAWDYPAARNKELIIHANGIERHIKLAEIGNLIPMKIPTFRDELGSRHQKIIDLNVIADGPTQKLILSNYRVSKSLYRPRVQSESISGGTEGFEIKSQDIAINFRAQLHLTGIGISLINTQPIELAYITFRDITIKYSESPFYQTVIGSIKWVQIDNQLYGGIFPMILYPSVVPKNSKESGSHPSIHAMITRVKDDSYGVLYIKYATILLQQMTLEIDEDFIYALLEFSKVPGASWSEIHEGTLCDESLDIPEPEQNQSGKDIYFELLNIQPMQLDLSFVRTDRVNVEDKTSSRNPFMFLLNVLTMAIGNINDAPVRFNALMIENARVSASILFQNFSNHYSQEALYQIHKVIGSADFLGNPVGLFNNLSSGVADIFYEPYQGFIMADGPEDLGIGIARGATSFVKKSVFGVSDSVSKFTGSIAKGLAEATMDKQFQDRRRMTRSRNRPKHALYGVTAGANSFVSSLASGVGGLARKPLEGAEQEGLTGFFKGVGKGALGFVTKPAIGIFDLASNVSEGIRNTTTVFDADGLDRVRLTRFIDTDGIVRPYSQREALGQFWLKQLDNGKYFNEHYIAHLELPREDVVVILTYSRILLVKSKKLITEWDVPLKKIQTISKERTGLGLILRGGVNGPFIPVIEESSRNFLYRKIGIAVESFNQKYKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFH0</accession>
    <name>A0A0B1PFH0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000444">
        <property type="protein sequence ID" value="KHJ35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFH0"/>
    <dbReference type="HOGENOM" id="CLU_031263_0_0_1"/>
    <dbReference type="OMA" id="ECLMILV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="63790" checksum="7FCC940062B1256B" modified="2015-03-04" version="1">MKVWVEWDIKRKTTIAKSLYNTPIEKTPTEWTLEEVSNSNEKFDSVKIVNITKNIKDINSPLTLQLNPQNSFLPLKEKSPYLFEPSSSKAQLAVNKKTLSPFESTSNKTQLTSNHPSSSQFSISQPAPDYARELVNLSNMYEPDLKYRGDDDSFDFELNIFLELCEKSGLPEEIYAKAYSTMLTGPALTHYYSITSNGHRKNFNKLSTATRDYFEGPETKRNRSARWESLNLPLVIAENESKGKSTLECLMILVKELRFLQLSLDPEYRSDKHLRLKLINACRNVRACQLACFKTSDTLSCLINDLQSSISTAEGNKEESTTQLFTDRRFHKIDLVPINATFATVKDIGHIIIPEQEKVKKIFKKRLFQRFKDNADHYIAEIEGRADDIDQKESNLEFEFDTLILETDTPTEDEEVSDVEESFLTSVGSFEKTQEIFLNLADNSFIHAVTGEDPTTLANEEDTDSNILMIKRYNDKYFYGIVIDTGASKYSTAGHKQSLALKKISNTYLDTTKAGSIKVQFGIGSSTSLGTTLLNTLIGNIQYHIVDADTPFLLSLLDMERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFT0</accession>
    <name>A0A0B1PFT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative iq calmodulin-binding motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFT0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFT0"/>
    <dbReference type="HOGENOM" id="CLU_020021_0_0_1"/>
    <dbReference type="OMA" id="PNLRIYH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="576" mass="66532" checksum="CE836BD258904E7C" modified="2015-03-04" version="1">MHMSVLRKKKDEAMNYYGKENPQPSILTDKSLGIPISQAKTQPSLLPLNSIFSINRSREYFISLRVPNREQIQYIAAIQERKELEITKRLFDENSMLQNSHSRIFSDAALGEKNLIREQVAFGSHMSPTDRWVEAIRELCYRKLIWPYEPKNMKRILAKPNHSRNIDTICNGNESSTLKARRNWKKAGLIARRAGRDEKPGSEPVINNELEKGCIQLCITNQSTKEQLRKKAKLMDLQYFLEMVDPKHRYGPNLRIYHEEWKRVDSLDNFFQWLDFGEGLQISCQACPRERLERERVHYLSKEERSNYLIALDCKGRLCWAKNGTPVDTSKKSSDCIKEKIPPPDNTTRIQAITMEPSQDVLKYQEMKNLSMNSSSFISCIQKSLSKYKKNGKYANTTAYATTKLNRTPNAKIIRNISVATIIDRLLRGSVKKNTWIFVADTDFRIYVGMKQSGIFQHSSFLHGSRVSAAGSIKVIDGKLRGLSPLSGHYRTPVTNFRDFMRALKEAGVDTSQTSISRSYFILIGLETYFKARTVTMKHFDRLKKDKTESHKPRIPHPRKKKRQIIKNLGAETNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFX7</accession>
    <name>A0A0B1PFX7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g2973</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="JNVN01000276">
        <property type="protein sequence ID" value="KHJ35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFX7"/>
    <dbReference type="SMR" id="A0A0B1PFX7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFX7"/>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="271" mass="30769" checksum="80A640CC5F679AE4" modified="2015-03-04" version="1">MACVKSSIRLTTGRSALRSVSTIRTMATVLSKESVSREKTFQIYRWDPDKPDKKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPADTSKETKIYPLPHTYVVKDIVPDLTQFYKQYKSIKPYLQRTSPSPNGKEYLQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAVLMQSYRWLADSRDEKTAERKSALDNSMSLYRCHTILNCSRTCPKGLNPGLAIAAIKKEMAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG93</accession>
    <name>A0A0B1PG93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000327">
        <property type="protein sequence ID" value="KHJ35609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG93"/>
    <dbReference type="STRING" id="52586.A0A0B1PG93"/>
    <dbReference type="HOGENOM" id="CLU_508247_0_0_1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="60876" checksum="4D5F8D95FFE8B379" modified="2015-03-04" version="1">MKACPAYVEELDENDQILPGTRRTARAPTTEHASDNKSKTILSPNREKFHQSEVNISDIKSKEKTSHSPKKNPISIKIPASQSYPLATMAGNYNSYYYGMPPSNEGHHQYYPQPHDSYSMMINDYSLPPEEAYAMSTELHSPPPPHPQPMSGYYQYPSMSPTAISCFPPHSPSYVRYSAQSSQDYGYQSHQEYAYPPLQEYSYPPTQEYSYPPLPRTTSRSLAARFQVRDQPWDRSIDPISRTASAFGTRDFPRQRSRTLEEGYESASDSHFLRNRAHERRVGAIGARSHPRESFNSESTSGNLLPRDRYIRGSQPRESSSSNTKSQESSRARRPSVSFDLSHKDENPKFEPPANSSRRRQCCYDQSTPESFTDYESKLKMASSYQEEAMGPNAPLPKRLDAPQLRKLQKRLDNTNRTSKSSASRDGSDLRKSETRTNRSGSPSEDQNVTIKVLTGSARVTLGGAQIDCSEGGAIEIKHDKVFGRRPSPEYINSEPSVDDHERRHRLEKQYGRPRVSSRAHRHSPDDSDYYNGSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGC7</accession>
    <name>A0A0B1PGC7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000201">
        <property type="protein sequence ID" value="KHJ35931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGC7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGC7"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006521">
        <property type="term" value="P:regulation of amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000765">
        <property type="term" value="P:regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="34970" checksum="89C1FFC32D506195" modified="2015-03-04" version="1">MTEQLILKGTLEGHSGWVTSLATSLENPDMLLSGSRDKTLIIWNLTRDESSYGYPKRSLHGHSHIVSDCVISSDGAYALSASWDKTLRLWELATGTTTRRFVGHTNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKFTITEKGHNDWVSCVRFSPNPQNPVIVSSSWDKLVKVWELSSCKLQTDHIGHNGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLNAGDLIHALVFSPNRYWLCAATSSSIIIFDLEKKSKVDELRPDFQAVGKKSHEPECVSLAWSADGQTLFAGYTDNIIRAWGVMARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGM8</accession>
    <name>A0A0B1PGM8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGM8"/>
    <dbReference type="HOGENOM" id="CLU_2833069_0_0_1"/>
    <dbReference type="OrthoDB" id="10455882at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="66" mass="7339" checksum="4A38F14C910F2D52" modified="2015-03-04" version="1">MGVKQGKLRDLCFRRQWALPKYSVAPCYSGFICTLAVAGQEFSGLWAETDEEAKENAAEKALKDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGP6</accession>
    <name>A0A0B1PGP6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative arf gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGP6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGP6"/>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="52456" checksum="681A54A9B8025D8E" modified="2015-03-04" version="1">MTEERSLASKSESNQIFEKLKSKPANRICFDCGQKNPTWTSVTFAIYLCLDCSSNHRNLGVHISFVRSTNLDQWQWEQLRKMKVGGNESAMKFFMANGGTAALNNKNPTTKYGGAVATKYKVEIQKRSEKDAAKFPGRVVITDNMNTESNSGDSTPASKDEDDFFSSWDKPVIKKPSPSQTTTPPIIGRPLSPFHHPVNGNGSEKVLSPLQDTKKSSVPEAGRITSSAALRKSGTVGTGQRKPKILGTKKNKLGAKKVTGDVIDFDAAEKKAKEEAERISKLGYDPDAEEPRNVTSESKVSTLSLITSPVSPSPSGQGYGDTGKHSAGQVERLGMGIGRLGFGQIGGNKPTTTSNKISGFGSVGSTQFNKDYDNDDEKYARQKFGAQKGISSDEFFGKGDFDPNAKSEAKQRLQGFEGASAISSNAYFGRPEDDVGGEEYGDLESAAKDFVRKFGVTAGDDLENLTQALGEGASKLQEAIRSYLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH27</accession>
    <name>A0A0B1PH27_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative high mobility group protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH27"/>
    <dbReference type="STRING" id="52586.A0A0B1PH27"/>
    <dbReference type="HOGENOM" id="CLU_042807_0_0_1"/>
    <dbReference type="OMA" id="KRQHDPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="40620" checksum="45902D2B0A53CBEB" modified="2015-03-04" version="1">MARAKKPEDKGGAILQIDVDSFVRTRDSIVTGLQTLQDAIRILSSAYIKHTNAVLGEHGTGIDVDAALAKLGEIPLLKLGDDISHTNSARKYSVENVPEKKERKKRQFDPNAPKRPLTPFFLYMQTARPIIANDLGSNVPKGAVGAEGQRRWQTMSDEDKQLWADAYKENLRLYLARIHAYKAGNSNAKDMNETEAAQYAIKHNITVSTLEHPVDASLVGETSTVAFLEEDVDAEPGLEPEPEKGIEVESESESESEPELEPEPEPEPEPEPEPEPEPEVILPPKTPRSKTSRKAKSLITSDDLPIIQKVTVPIIPKAASIDKEKSPEKKRKRTKRKDGPVEKEEPSIETQRIIPKARKKRSKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIK3</accession>
    <name>A0A0B1PIK3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIK3"/>
    <dbReference type="STRING" id="52586.A0A0B1PIK3"/>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="OMA" id="AGLDFHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="303" mass="33008" checksum="DA910E3A70EE1570" modified="2015-03-04" version="1">MMAPKYLTGDHAAIESFIDQFETFLFDCDGVLWSGDQLFSGIVETLDLLRSKGRKIVFVTNNSTKSRAACHQKLASLGIPSNPEEIFASAYSSAIYIARILKLPGPKNKVFVLGEAGIETELRSEGIQFIGGTDPSYRRDITAEDYKLIADGSLLDENVGIVLAGLDLHINYLKLAIAYQYLARGAIFLATNTDSTYPSNNTLFPGAGSISRPLVNMTNQSPLALGKPSQAMMDAIEGKFKLDRQKTCMVGDRLDTDMKFGLEGNLGGTLLVLTGVSRKGDWELNDSAIVPGYYIDKLSDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PJ13</accession>
    <name>A0A0B1PJ13_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000010">
        <property type="protein sequence ID" value="KHJ36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PJ13"/>
    <dbReference type="SMR" id="A0A0B1PJ13"/>
    <dbReference type="STRING" id="52586.A0A0B1PJ13"/>
    <dbReference type="HOGENOM" id="CLU_012437_1_2_1"/>
    <dbReference type="OMA" id="ECSHEYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="603" mass="69284" checksum="8713A089352E1535" modified="2015-03-04" version="1">MKGFRQRVLSRAKDPNKSSKSKNKGESKDVQASSKDAPNSSLSTPSSSTATVHDFRSKPLPSGDSILPNIRVSSPSGQRMVTSLSPGPDRFPGAGAATPNNGGQGISSRYGQTTSNVVISPSANQISPPGTAENMPYDLAPPKAGQKPMIFDRLQMRPKDVPEGIRTPRRQHSSRFDISPQRELEKLPSFNEVPPNRRQELFMQKLEQCNIIFDFNDATGDIKSKEIKRLALHELLDYVANNRQVITEAMYPKVVDMFNKNLFRPIPPPMNPQGEIFDPEEDEPVLEVSWPHIQVVYEFFLRFIESQDFNISIAKAYIDHSFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRSYIRRSINNVFFQFVYETERFNGIAELLEILGSIINGFALPLKEEHKLFLTRVLIPMHKVRSLSMYHPQLAYCIVQFLEKDSALTEEVVLGLLRYWPKVNSTKEVMFLNEVEDIFEVMDPVEFTKVQEPLFHQLAKSVASSHFQVAERALYFWNNEYFCNLISDNVEVILPIMFAPLYENSKGHWNRTIHGMVYNAMKLFMEINPQLFDDCSLYYTEQQNNAEAREQARENKWRSLEEQAAHARSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUJ1</accession>
    <name>A0A0B1NUJ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005511">
        <property type="protein sequence ID" value="KHJ30037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUJ1"/>
    <dbReference type="HOGENOM" id="CLU_778887_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="40559" checksum="E933C8C58C975051" modified="2015-03-04" version="1">MNEPKTPFSMDDLPRILGNISKMYQTEDKKYNGWNDSLDYKMDMYKDICDINQCPLDRRMDGLILALKEPALGEFRAHRHDVGMTFDGMINHFRGCYEGIDFKRSELQAWHTISYKLNKEQNQKRPPSGCVVILVDALNAKRRSLDLSQRTDDAMHTRLTNACWGIPEFQSALSDPSSHLPTFINQLKMAVKEVKVDLSNWQSMDQSKLDKMSEWVTGNTKAANSIMYNCETTPQLVITNYQTSAEMWRALEQAYEGTGIVVQHQELIRFVTFLPKALTKNEPHILVKDRWLADSGADTMITNQFSDFLEYTVDQLEIQGAGGITLSPGVGTVQLNVALTNGTMRQINLSNVRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVH0</accession>
    <name>A0A0B1NVH0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004491">
        <property type="protein sequence ID" value="KHJ30317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVH0"/>
    <dbReference type="STRING" id="52586.A0A0B1NVH0"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OMA" id="AQNWPLR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="146"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="65120" checksum="BB847C603472910B" modified="2015-03-04" version="1">MDTPHQTVSNHEYDANHTVSFDPSAYVLGKPKMGRASSSSTVTMTNFSASTSVQSFPVSRTSTHDDVERNPYLCIRSQALSGHDCNKNDSNVTIQGRESRVSLPDSGLVKWYPPPLPDPNLYLVDFNGPDDPMHAQNWPMKKKLLTTAMLALTTMISVFTSSIFSTAISTVSNQYNVSFEVGILGLSLFVLGFAFGPMFWAPMSELKGRRLIIVWSGLGFSIFQIGTAVAKDIQTILLCRFWGGIFGAAPLAVVGAVFVDIFDNRTRGIAIAIFSMVVFIGPLIAPFIGGFITNSYLGWRWTQWLAAILGFTCFLINLFFLEESFDSVILVAKAAKIRQKTHNWAIHAKHEEIEIDLRQLFANYLSRPIQMLFKEPIILLISIYMSFIYGLLYLFLTAYPMVFQGIHGMSPGIGGLPYFGIISGMILAGIFVILIQPSYQRKLAANNNIGVPEWRLPPMMLGSFAFAIGVFWFAWSGYKASIHWIVPTLSGILTGFGLLIIFIQSLNYIIDSYLMFAASALAANSLLRFLAGAGYPLFARALLSSLGINWSCTILGGISTILIPIPCVFYYFGHRIRARSSLSQNFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVW8</accession>
    <name>A0A0B1NVW8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g1125</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01005055">
        <property type="protein sequence ID" value="KHJ30123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVW8"/>
    <dbReference type="STRING" id="52586.A0A0B1NVW8"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="198"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="400"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="565"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ30123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="69919" checksum="A2C78865676521D4" modified="2015-03-04" version="1">MADQLNMNGLNLNAGPGEQRSYIPPHMRGKMGNINLNGGINSSAWSNPEKITSGGNNWASAPNFTPSGGQPSNSRPSGGAQWENYRERPTFDRNEYAPQSGGNAPRGAGDGQWRDGQHIAGPANPRLERELFGVADDPTKQQTGINFEKYDDIPVEASGTNVPAPVLKFNNPPLDDHLLRNIELAHYKVPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILSQAFINGPSAVPAGTGGNYGRQRKAYPTSLILAPTRELVSQIFEESRKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLQNIKYLVLDEADRMLDMGFEPQIRRIVEQEDMPGVQSRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDVDKRSVLLDILHTHGTGLSLIFVETKRMADSLSDFLINQNFPATSIHGDRTQRERERALEMFRNGRCPILVATAVAARGLDIPNVTHVVNYDLPTDIDDYVHRIGRTGRAGNTGISTAFFNRGNRGVVRDLIDLLKEANQEVPAFLENIAREGGGFGGRGGGRSGGGRGRGGGANRDFRKYGGGGGGNGPSYGGGNFGGPPTLSYGSGSYGGSGGGGGGYGGSYGNPSAGGGGGGGNQSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWG3</accession>
    <name>A0A0B1NWG3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003726">
        <property type="protein sequence ID" value="KHJ30712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWG3"/>
    <dbReference type="HOGENOM" id="CLU_030818_1_0_1"/>
    <dbReference type="OMA" id="RWWILSK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="473" mass="52580" checksum="42125534A3C1166B" modified="2015-03-04" version="1">MLATSEGEKKVHNTITTGISIALGLNISSSFRHIAMAMRWSILALGKYNLEEMNLILKPANLMTVTKLAFVSRQPKIFTACLAWLLLNISIQFGIALISLTCYFDLDPNSVRLSPGIAAIPMMDHFYPQTNHVVNGQSIQDEQYTAHTYGESALNFGVGLVSSEPIPGKRYFPTDPLLWLDKSNSIINFIFIDSPKDSLVIDSFSAFTERKISVTYSCNSFAVLSRGDGTVTQINVDRVGNIVLPQVVPDSTTYLTRSNHTCKGDNRCSVVEVFESSATDPWYYVCEISLGQTQNDPQGVSSVSDYLAQIATATIAQVGYTDSRGYASQIYPRESLWGQELKGDADSVGMAIGIYALSSIAGAAQFNPFTSYYTPNAPSPGYLLIFKHKKIFYAILIIVNIFHLSLVLIVNTARSGPNEITGTCILLRPITDQFTTTQRQKDMKRYDEIMRQTYVRYEKDSDAKDLWKFNIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX43</accession>
    <name>A0A0B1NX43_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative apses transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003435">
        <property type="protein sequence ID" value="KHJ30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX43"/>
    <dbReference type="STRING" id="52586.A0A0B1NX43"/>
    <dbReference type="HOGENOM" id="CLU_016460_0_0_1"/>
    <dbReference type="OMA" id="HEAEYTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="640" mass="70240" checksum="1869FB1CE7BC58B4" modified="2015-03-04" version="1">MNHNPQEMYYPSHLSAGHAHHPPQTPTSNALSHFSPHQHSQHVQSGHPHYASSPGPYGQYSYSNGYTTQQSGNHQVSANMCQQGNVLPLPTSLNTGSSNVVSSQPYPSQPVGFDLTGQIAPPGMKPKVTATLWEDEGSLCFQVEAKGVCVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKHRHVVKIGPMHLKGVWIPFDRALEMANKEKITDILYPLFVQDIAQLLYHPTNQSRANQVIAASERRKLDQEQIKNSLSHGMSSFHQHHPSMNTAMSNIQGDPSHSLTPHPNWGRPPLDRIQNFPTPPTSASSVMGSMSNPDSNFQWGSQCGIGHVLSGNSMQIENGISHSRSVPNTPASTPPGTSIHGLQYTQTGQSYDPPRHVYSAPPPPPPPITASSQQNIYPHSSHDQQVNNRYSTSSHNTSNSNSNSNNTYLKNELVSSSSRALHTESESHEAKNLSSTHNQSHQQSTNEEEKEQENELEYTHGSEISPSPNHPKASTPSGRATPRTTGPTQTFYSQPQNYTSSPRHPAPSSNLYNVISSERGSPNSNHTTETFSTPPDNVATANGYLNSPQNPHSSGKKRARVDDDIKSNSRAIANENEAMKRRKILIPSNILIHDSPGKICSTSPINQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXD1</accession>
    <name>A0A0B1NXD1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative kelch repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003304">
        <property type="protein sequence ID" value="KHJ31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXD1"/>
    <dbReference type="STRING" id="52586.A0A0B1NXD1"/>
    <dbReference type="HOGENOM" id="CLU_008722_0_0_1"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="604"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="699" mass="80164" checksum="81ACE6FA7FEB6157" modified="2015-03-04" version="1">MAKDKKGKSDGKKAKIVEKKQKQEKKSGLKKEKTKKKHLNYDSDAAAEDDNLDLEAVLASYAREQEQFLKVTEVSCDPPKPRSSTSFIASPTNSNELFLFGGEYFNGAIATFYNDLYVYLINKDEWRSITSPNSPLPRSGHAWCRGGNQRSIFLFGGEFSSPKQGTFYHFWQLDPSTREWTRLEVKGKPPPARSGHRMTYYKNYIILFGGFQDTSQNTKYLADLWIYDTLTYAWFSPDLPSSMQKPDARSSFSFLPHEKGAVLYGGYSRVKVTVNGKPGKGHVQSHKSVYKPVVHQDCYFLRINQPDTSAASISSLTVRWECRKNPTNTPKPSRAGATMTYHKCRGILFGGVHDVEESEEGIDSEFFNGLFAWNIERNRFFPLTLRMPRHKVIKSIHEDEKSGRRGRGQANEEDLLKNLALIEAKSSLPNDENEMIEEKEITFESLPEKEISLELPHVRFNAQLTVQGDCLYVYGGTFEKGDREFTFDDMYAIDLGKLNGVKQIFRRETENWEGSDIEQSDLEEDEDDDIESKEEESDQEYIESNTKMLSKTNRPDTTAKKLNLTLAKDENEQLKKQESHEISSEMLASNIDDNLQEGTAVNSSDNPYPRPFESRKSFFERTGNEWQELLMTNLRWKGILPETLTVKEIKTKAFELSENYWWECREEIIMLEDEQLAAGIGEVVTLDKKETTSGVFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXK4</accession>
    <name>A0A0B1NXK4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cofilin tropomyosin-type actin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003729">
        <property type="protein sequence ID" value="KHJ30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXK4"/>
    <dbReference type="STRING" id="52586.A0A0B1NXK4"/>
    <dbReference type="HOGENOM" id="CLU_129657_0_0_1"/>
    <dbReference type="OMA" id="WIGPNCK"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="16181" checksum="093B6C8CAA47DA72" modified="2015-03-04" version="1">MSFDDQSAILQAYNAVREDKNASNWLILSYVAASGNRLKLDCTGTGGLSELAEKLDPSQAQYAYARVEYANDTESKRVKFILVIWIGEYTKVMRKARVSIESGAVKQILGHHSIQVDARDKLDLDEKDVIIRLRKAGGADYNGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXS1</accession>
    <name>A0A0B1NXS1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin-like protein smt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003147">
        <property type="protein sequence ID" value="KHJ31187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXS1"/>
    <dbReference type="HOGENOM" id="CLU_087700_1_0_1"/>
    <dbReference type="OMA" id="PTQFEYP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="19589" checksum="5E96E714CFD3BEBB" modified="2015-03-04" version="1">MSGAIENKSIISPTNALRKLSIEPQTPHKHRPKDVSRKDKDIPSGSWEDEITSSGDEEYPYSPQQPTVYPSAPPPTPISPITQPKFESPFDYNVMGISMTRNEQRITSRPDKTDAIARRLIAGALGVKPPPKSEEQKAYEAAMKGKEIKRRAEEKELLSKALEDAERSKEAMWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYC9</accession>
    <name>A0A0B1NYC9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">EV44_g1112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002952">
        <property type="protein sequence ID" value="KHJ31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYC9"/>
    <dbReference type="STRING" id="52586.A0A0B1NYC9"/>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="296"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="461" mass="52770" checksum="003BD56552B43861" modified="2015-03-04" version="1">MTIFRPPIVRSASLTLDRSLFSKVFPAAAARVQDSKDISRYRNELSKTREILKLERFLNIRPDPDPEIAAKGGKCVVLDPQVKPEDPATWSPMLAEAVITNKLKVLSYDVKLDYDYWSYLDIMTSILPEHAQGEIPVGFAIVGQIAHLNLRDEYLSFKKLIAEVLIDKNPQIKTVINKIQDVGEESEFRTFKYEVLAGPDDMKVELSEGGCNFKFDYSQVYWNSRLQTEHKRLIDAFNPGEMVLDVMAGIGPFALPAGRKKVFVWANDLNPECYKCLAEGIVRNKVHNFVRPFNKDGRIFIRHSVKELLQLASSNENLVLQPPRQRDKHSSSLKKQIMPLPLVPSHFVMNLPAIAIEFCDSFSGLYSGHDKLFEPFSDRLLPMVHVHCFSTKSKDNVQESIDICERISRAMNTVLLPKFETGELREGEVRIWDVRDVAPKKRMFCAEFRIPREVAFRRPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYJ9</accession>
    <name>A0A0B1NYJ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005116">
        <property type="protein sequence ID" value="KHJ30110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="OMA" id="TMPSINE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="34437" checksum="636D96CD0690836A" modified="2015-03-04" version="1">MHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLSCTPSDITRITRTSSGFALTVKGKETRQKLINDSDGISTQGAKLEPVSDLITYRIATVPVALRTSNGNVTVNDTNLASEIVRVTNVAPKMVRLGGKTRVGAPHRSWLAHFPRDQAPRPGFRLFDESGVAVLYKPRRSIQKCKRCHGFHDTRGCSRVPACENCSSTMPSINECKAPIKCRNCGGPHRSDSRNCLARLSRSGPASKDQLKTIRQMGQREYHAKARAEAAVIRAEVATTPAERLLSTNQNNLQAIIPTNEMAMSEAPTEGDIIPETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYS5</accession>
    <name>A0A0B1NYS5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002788">
        <property type="protein sequence ID" value="KHJ31557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYS5"/>
    <dbReference type="SMR" id="A0A0B1NYS5"/>
    <dbReference type="STRING" id="52586.A0A0B1NYS5"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_0_1"/>
    <dbReference type="OMA" id="NDARDHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080382" description="cutinase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="26274" checksum="43FADDD867413D7F" modified="2015-03-04" version="1">MINFNMRNLALLSLSFYFTLITASRENYDAVSPQRIDAIERVFAFYQARQITNFAERNSENELSGPCKPVTLIFAKGTGESGNVGGNHSPGPALFSQIRLSMGSQNIAIQGVDYKADIFGYLKGGDPEGSKRYYNLTEEAATKCPDTKIVLTGYSQGAQLAHNAARWLSVNTTQRISAAVMFGDPYSYDTMGFLPSTKVLNICHERDVICDGVSGGAAHHLTYARDAPEAARFIMKCVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYX0</accession>
    <name>A0A0B1NYX0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002742">
        <property type="protein sequence ID" value="KHJ31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYX0"/>
    <dbReference type="HOGENOM" id="CLU_072123_2_0_1"/>
    <dbReference type="OMA" id="SWKETGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="27233" checksum="95EF31D22DFCE791" modified="2015-03-04" version="1">MLSKLSTKIALRKVGIPSSALTLPDTSSIFGAGSGSGSGSGPRDPNAPSPLSSLLSGIQVPASLKSWQSPLPPPVEIAAPPIEGTAAPSCMKLSLPFKDGTKRPSVIVFLRHCGCPFAEKTFLLLRTLANKYPNISCIAISHCSSQATEKWLKDLGGAWAVQIIIDEDREVYAHWGLGISSTYHLMNPWTQIAARKLGNEEGIWARDVDESANRWVIGGAWCTNNLGSIQWGRANTTADDIPKFEEAVQKLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ81</accession>
    <name>A0A0B1NZ81_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004499">
        <property type="protein sequence ID" value="KHJ30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ81"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ81"/>
    <dbReference type="HOGENOM" id="CLU_074897_1_0_1"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28391" checksum="45D70904E708F53A" modified="2015-03-04" version="1">MGWTWFSNETSNKKDNIKEKEVEKTSSDTKSLVPSLSTSVSSTFSSPSFENNDNAEREFGVLFSEASKKSIAEDELNQINSSTSADYQPKLESASNRTINTTFDHPKSISEQLLPTDMSCREAFDSAFYCNSLGGSFNHLYRYGTARSCNEHWSKFWFCMRIRTYDDESKKTSIKNFYREMEKKKYSERGTSSEDIWKSRDQLVKKGTAFLATEEEWNRTDEEWQNDALEMRKRIIEAAGSSKNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ97</accession>
    <name>A0A0B1NZ97_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002632">
        <property type="protein sequence ID" value="KHJ31717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ97"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ97"/>
    <dbReference type="HOGENOM" id="CLU_010895_0_0_1"/>
    <dbReference type="OMA" id="FSWLQFC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="107184" checksum="9E060B2E5AFF8482" modified="2015-03-04" version="1">MQVMPVPTENALRILRNIALGTSCTMAFIFGILLDERQRLLQTAHRTRRNIKILKSSKRYTTKGASAIRAFEEKALRFDDDITADKLQSDLSPSVAKSIISQSTVAEGEGTAAISKLSNLESPNDIITYHDCEPCGQLQLRKLNSVRVLSTSPSIQRKEDISFLSVLEQRISYFLDQSPPQVETAAKIFIGTLENGLEFNGASFTVFDNFKALSLALALFRACTREFRLDISKRIFYSVMICAINERIFITFQLEKIIEKLMNGVSPQNINEIASLYFATLDRYTESISSQLLVLGHKLCETAFKYGKYQFVQETFRRMIKLCSKFPIGSLSYFIIAASHEQDYQSEVFEYFMKYFANTIPSENHHNKVVKVIVNHLLANRMFAEAEQVIATAENISRKSGYFSPATPCLILIRKNWEVYQDLDKTVALFDRVGYYIQSVRNQCVFYDIIIKICIEADDTLLAWSYYNKSQKKNCLKAQCILVQSTLLKAHQGDFEGVKNDLEKIDNAEIADKYSKLFPKILKIFSSKNDMTSVENFIELAFKMGISLNSNSINKIAELYAKERNFESIVCLLHYATNKGYPIDASFINMILKQSNDSWKYSIEKVLLLARIIIELDSHNPIIDCNTFLVLRRLISSNRRASIKWKNKISEKLNLMFEPYHFEQKNPFNPNHILSEMVVSLNLNDPQETLAIYDWARSEDVRIGSKHLNVAVEASFRYYNGDISEGMKRVRKSGLSGAQTAESIALLFVHHLQSLANKKTNSAEDIVQLTLSFISSFEKHNFQIPIQVITQTISTLERLRKYYDVGTFWDLVSNRLGLHLVKPNIETLTVFLNTYIKLEYVPGFWKIFQIMIKNRVFPDQRFCLTLDNARRRVSLELRSPIKSNPQKSAFLDTILEGRTLVKQIRSQNFSERHIGTTKVIKKIEENLRLLKSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZE7</accession>
    <name>A0A0B1NZE7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004313">
        <property type="protein sequence ID" value="KHJ30405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZE7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZE7"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="OMA" id="IENCWVS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="46378" checksum="FB4682DE7DB49BC7" modified="2015-03-04" version="1">MEYLMESQAPLTEMSSSIPPIPPIPPKTLPLPNPKTPPSPPQNNKPPSDQVLNRKILVPVIPTKRVASNATDSSKTGHSNEVEDTHPYMPRELLEIFTARKRQEQAWHTRLMVCTCFLSGIDGTVSNFQEGAEKEMAKTIQAYLRLAISEFAAVDTIPDVPKFIPTETILKSNSASKVNLPRKPPVVATPLRNLTEKTKHGHIQASDPLPSTTKNIENCWVSVTRNGHKKSRTIKKSVLQTTKAKKQNTQTSTGSDKRLFLRLTDDHEWRKLSPAGIREIVVKKLSISPASISTIKPVRSGFALSLYKDETRQELLKAAIRLSPFDAKLEAASNWTPVMVPTVPKTINTLEGKIELTKDMLANEIERVSLVRPAFLKMFGRNIPDAPHRTWMAYFSKAPRPGFRVFDESGIVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH8</accession>
    <name>A0A0B1NZH8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome-c reductase complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002953">
        <property type="protein sequence ID" value="KHJ31363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZH8"/>
    <dbReference type="HOGENOM" id="CLU_138679_1_0_1"/>
    <dbReference type="OMA" id="LKHWPTD"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14713" checksum="9C4B8A3F282355E5" modified="2015-03-04" version="1">MSKSIVYNHYLRALSKWPQDALRPECQFKDSVRKRVDKLFLRNTTAVTISERINEKSELEQVNALYHLLENRFSQRYPLRGLLMKPESNPNYYSDLVTELERAPSRGFWDRMKKKIQGMLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZK8</accession>
    <name>A0A0B1NZK8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative g2 mitotic-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002919">
        <property type="protein sequence ID" value="KHJ31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZK8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZK8"/>
    <dbReference type="HOGENOM" id="CLU_020695_9_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="390"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="483"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="487"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="638" mass="73106" checksum="49739FF0FD0F0089" modified="2015-03-04" version="1">MDARPQRSIRIMRSHPDENCAPAICNNQYLHHRQKSANQMATLPVGGLKATAKRTAFGDVSNTVKNLSNSQDDLRRTQNEFKSSDIQEKSNFFKPTKKHFAIAATKISKNNTKTNIDINYLGTSSKAAPSNSHSSIRRTSSMRSTSIYQDAIAKNKTVAQNQVYRYESTKSGIAAQYEARDHHEGIQMCSASINPNYKKYGHYLPETFKKITTSHDISEENSEEKVIASNETFHTARENLIEDLCSDDKNSIESETDLAQNQVDKPSLSSLLSDSEKDDDDDESYDDQGHLTMYSYRSCGENTTNGATTTLYPKVTNKIKQELESAKKFTEEIRTIEDIGDEIWDTSMVAEYSDEIFAYMRELEIKMLPNAHYMDLQTEIQWSMRSVLMDWLIQVHHRFSLLPETLFLCVNYVDRFLSSKIVSLGKLQLVGATAIFVAAKYEEINCPSVDEIVYMVDGGYTVDEILKAERFMLNMLQFELGWPGPMSFLRRVSKADEYDLETRTLAKYFLEVTIMDERFVGSPPSYIAAGSHCFARLLLRKGDWTKQHVHYSGYTWTQLRPLVAMIKECCEFPQEHHNAVFEKYSDRKYKRAAQFVYSEIRNFSLPSLQPYKPSLPSVENIVQNPHHKQELLNRLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZU6</accession>
    <name>A0A0B1NZU6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc knuckle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004845">
        <property type="protein sequence ID" value="KHJ30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZU6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZU6"/>
    <dbReference type="HOGENOM" id="CLU_861060_0_0_1"/>
    <dbReference type="OMA" id="NACHLIT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="37118" checksum="64055C558E9C0D9D" modified="2015-03-04" version="1">MEKRHGYQVPYGRESRSILRSNPNQHDTSIRSTFEERPSRPQWKNADWAEFIERLAIKLRELVTTKGQLTTTKDIDQRVTDITKMIQNIAEDLIPKVKSSQYAKPYWTKECSRVVTAARKARRERRAVVSEASNDPTKLWKLAKWARKNAKEKHTLPQIPDIIDKEGKIHTEAQKKARTMAQHFFPPPISANTQDIVGTVYPEELQTIVKNICQNEVEQTLGMIPSDKAPGPYRIPNRLLKHCRKALSKVLVDLFNSCLRLGYHPRGFKESIKVVLRKPQKPSYDTSKAYRPVALLNTVGKLLEKLVANRISKAAEDHNLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J1</accession>
    <name>A0A0B1P0J1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative vacuole-associated enzyme activator complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0J1"/>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="OMA" id="QCYQHVS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="591"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="858"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="901" mass="100527" checksum="7205DA0754864B47" modified="2015-03-04" version="1">MDPGIQRALNDKIYEKRKIGALDLERVIRDYVATNNLDKIKKIINQLCDDYAFAVHQPHARNGGLIGLAAAAIALGPDLPHYLDEIVPPVLACFSDQDARVRYYACESMYNIAKVAKGEVLPYFNDIFDVLCKLCADSELSVKNGAELLDRLIKDIVSESAATYVSLLHIPEVPQDNKDVSVDEPDDLMTAFSLARFIPLLKERIFVLNPFTRTFLVGWITLLDSIPDLELVSYLPEFLGGLFNFLSDPNSDVRVATQGALERFLGEIKRLSRIKKGIQASRKSRSDTKRRLVESLGSENSILPAAGEEEESITGGDDVNTSSDDDWVPGQDVVVNYKEILEILTANLDSPLEENSLLESLRWIVGFLDICPEEVLPFAPRILAHLLPAMASGVETIRQAAARVNTSLMDYVVSLSDEGTLLESTSVGISKPSSSVIKDSVNNDKKEQSNNTRGSIAGSRNGDRRESEVQTPPLSQSKLSLSSNQVSREQQPVALDYAAAVSSLTLLFLNDHEATRVAALTWLLMLHRKAPRKVIAFNDGTFPALLKTLSDPAEAVVTRDLQLLSQISKNSGDEYFSQFMQNLLQLFSTDRKLLETRGNLIIRQLCVSLSAERIYRTLAICIEKEEDVEFASIMVQNLNNNLITAPELAELRKRLRNLESKDGQTFFVALFRSWCYNAVATFSLCLLAQAYEQAYNLLLVFAELEMTVNMLIQIDKLVQLLESPVFTYLRLQLLEPEKFPHLYKCLYGLLMLLPQSSAFAALKNRLNSVCAIGYLYTAPRAAPTNASTSGLDRSSRLKGREESGIKWHDLLEKFRSVQDRAKRTQRVLDDIDDGPEINDINSRDFLDDRTFKDLARLHGPSLPTKDATTTQSGHPITQKHKPSLGSFRRLGGAMQGGRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P1</accession>
    <name>A0A0B1P0P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pr-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004362">
        <property type="protein sequence ID" value="KHJ30384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0P1"/>
    <dbReference type="HOGENOM" id="CLU_035730_9_1_1"/>
    <dbReference type="OMA" id="ASKLEIC"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="34"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="19316" checksum="81E7DC06E374E66E" modified="2015-03-04" version="1">MLLRPYLIAISVCFATISNKNFHVLSALMVEMSSDVIDALQVHNQARIKAVGPERPSLIWSESLAGAAHTWAKHLANENTLKHSSSSGQGENLFSRIGKGKATFAMAATAWVDEMPLYQGEAIPVGDFEAYGHYTQVIWPNTREVGMASAKSKQGWTYVVARYSPPGNYVNQTAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z7</accession>
    <name>A0A0B1P0Z7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-tubulin suppressor protein aats1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002489">
        <property type="protein sequence ID" value="KHJ31903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Z7"/>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="OMA" id="GWGNCRK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="38822" checksum="4F5F2AEE1C63D4D1" modified="2015-03-04" version="1">MIQIYAFGSNGSGQLAINHKNDVSMPEKTFVLDEFPINSIKQLRAGGNHTLLLTGGHLYTSGTLSSDSIGCIYAYDKFSRVSIPDESTSQLPVIYCAATWEASIFVQKNKNGLSNKVYTLGNGYYGELGQGETISVLPDAMLIKEFPPPRLEIKDLAASVSHVVVVLNNGEAYGWGNGRKGQIGEPKRNVHRPRKILGLDFKIVRVVCGREFTCLLGEPETGKFIILGSDKWSIISSAPAILPGWRDIGGGWGSIHVLKENGKVVSWGRNDQCQLAPSGLPEVLQIAVGSEHALGLTTDGNVIAWGWGEHGNCGPLLSGRDTVEKWNTFTAERLGDGYKFIGIGAGCATSWIYAELPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P113</accession>
    <name>A0A0B1P113_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003375">
        <property type="protein sequence ID" value="KHJ30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P113"/>
    <dbReference type="STRING" id="52586.A0A0B1P113"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="OMA" id="DDTMANC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="561" mass="61779" checksum="DA7FB9D2A40EBFF9" modified="2015-03-04" version="1">MEMSSHTPPIAPIPSLPQSPFPIATSPSPPSSTTPPNSVVENRKIIKPVLPSKRAAQNAAVIDLTNDKNNRTSSHAYLPQGLTNIVLARQRQERAWHIRLSICTCILSNVESTFSIYKEDIEREEADVIRKYLQKAIAHLVASDNAPQPPEIPIESKSSKMKSLNLPRNSKIIDSHVANSKTPTLPSQNYNHNIKGQVACPKQNENSWVMVARNGHKKARTIVPLASLSTGQSTKHKLLPSYPQHQKRDVHKKKTGKENKSDNRLFVRLPADHEWRILSPAGLREVIVKRLSVSPVSIGLIKPVRSGFALSPSNNESRENLLAAAGGLFMSGATLEAASNWTPILVPTVPRSITMLEGQVEVTKSMLADEIERVSTIRPAFVKLYGASNPDAPHRTWMAFFSEIPRTGFRVFDESGVTRNFKKKQQIEFCKRCNGHHNIRTCSRAPSCGNCGSTMHSQDVCMAATKCRNCGGPHRSDSHRCLARPTRTSKPTKEQLKVYRKAGDREYQAVVRANAAEARALSAEQSDGVNETPNSSQISETNAENSNIAPVTTSTGVEMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P130</accession>
    <name>A0A0B1P130_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g6510</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01004046">
        <property type="protein sequence ID" value="KHJ30534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P130"/>
    <dbReference type="STRING" id="52586.A0A0B1P130"/>
    <dbReference type="HOGENOM" id="CLU_004624_4_2_1"/>
    <dbReference type="OMA" id="WYWTWKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="297"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ30534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="656" mass="74319" checksum="CAC9E813C755B5D4" modified="2015-03-04" version="1">MAQTSKSRRLQYQQRKNARSNKKRKRRPATNADIHKLSAAALAKHNQLQQEMSQKPQDVVTKEIPLRKRSDISDLNTEMYHRRYYSSRSENRRITSGKLLEAGMIAKLRGGGGDDNKFTLNKRKLLCIGLGIIIVILLITIATVVLSKKKKNHPSIINQVTTSDSGKPSNANLNNIAESSIPMEAKDTYLDPFSWYDTTDFNVTFTNETVGGLPIMGINFTWDDSNSANSNTPPISHSWGSYSDRPTRGVNLGGWLSLEPFITPSIFKQVGAIDEYTLVSRLGNKAKDTLEKHYATFVSEQTFIDIANAGLDHVRIPYSYWAVAVYDTDPYVFRVSWRYLLRGIEWARRHGLRINLDLHALPGSQNGWNHSGKLGQIGWLNGTNGSLNMRRSLEIHDQLSKFFAQDRYKNIICFYGLVNEPKMTVLDTNAVIEWTNEVSKLVRRNGIKAHIVFGDGFMGIGNWKDKFYDNSGLVLDAHQYVIFNKDLISLSHTKKIEYACDEWKLQAQQSMNPSTGFGPTIFAEWSQTDTDCAPNLNNVGWGIRWLGTYDPGDPNYEVLKPACPLGNSKCDCANANADPTRYSKAYKKFLKTFAEAQMASFENGWGWFYWTWKTEVATQWSYQLGLKAGILPEKAYAPEFSCTTEIPSFAELPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P150</accession>
    <name>A0A0B1P150_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative blumeria specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002449">
        <property type="protein sequence ID" value="KHJ31958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P150"/>
    <dbReference type="STRING" id="52586.A0A0B1P150"/>
    <dbReference type="HOGENOM" id="CLU_361380_0_0_1"/>
    <dbReference type="OMA" id="MLNQRAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="774" mass="89218" checksum="7EF11A13F539E76E" modified="2015-03-04" version="1">MLHHYPQVPPIAQPVISIPHSLYTQSPHSQPQPQLQPQPIPPTVTVSFLPPATSLYANLLQPLSIKIIQSFAHTPLLHQYQLPTSTFGLTHLYPPHPLFLLTQSSPHVPLRPVHIFLPAPSQHALREFCTQSEVLLPCGGGRIELIEFGERCCVTDLDGNIIEVHWSSHHTARTNGYLIPDAPSQLSHPQRCKVKSLAYSSYRERDKSREKRKENEVRIYGEDRRIRQSSKNEPIVSENMTLEAESKPNTKNRRVLQWQKDVAKSINYEDVDSEDLDNSNEFVSSEDDEHPLADARSYTRSQSNYRARSGRNKAHSPYHDTYETSDNYRTRKDYRENYKYQKSSKRRNGSRKRREVNFIEDHDDSFTPKSKYGHDTAAVNVRSKNNDYLITKTPANKNNAISRRADMYSESSSSPSKYTYNRYFVPKKSSDLSANYISRRASTRPSESKHIMPNNSDRRDSGIGGICDYSGGELERGEFEKHPRHKYRSSRSITSKTPGDTRPRYLPRTSPKSHNHNDEYKKTEDRTGKRLHRKSRTSFKHQSCSSTSSDKFDDESYDTISSKSEFFSKHESSSVAKGREEEKRRRWIEERDQVRDLHRKQLGRELAGKNRQKSSRKSNRHHSSVRSAAPHSPSSVSGSAKRDNQQILARVPKPPSAVPPLTREKSKRFEKRHRDDYDDNSDDFSDSDSGYDLPITERKSHRRTSYLNPSPRHHSSRRQSGGDFNYSSGGKRELLSRHNPSRHEYATSDAISEGFTSESDQPRFGRRRSSIRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P173</accession>
    <name>A0A0B1P173_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002139">
        <property type="protein sequence ID" value="KHJ32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P173"/>
    <dbReference type="STRING" id="52586.A0A0B1P173"/>
    <dbReference type="HOGENOM" id="CLU_005884_0_2_1"/>
    <dbReference type="OMA" id="HNHPVWD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="85"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="520"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="564"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="729" mass="81368" checksum="F2EF14DABDC3FAC9" modified="2015-03-04" version="1">MSHHQPQGAGNATSNSGIGTQQQHSQYESHPQSQSMTQQNLNQIVIEYLVKKGYNRTEQMLRSESSRLDKDGRPIQDRVEDLGHLKYRRAFKLLLNWIESNLDIYKFELNRLPWPIFVYSYLSLVRDEAVVEKEIFFNEFSSKFEKLHADEIREFSLVTLPTHVNANPTAKLYCENRYKLPLNQHVYFNLITFLESNAKSGGTVILSLLQTYFEIKETTRGPIDRFSFEAIINNAKNQEIDEKELEEGIPGAFTGITNKDMTHNNATLKLGMMPLDPELIVDVRSELEEEDAKNPPDLGKRSLVEEFELSIKRGSSDTPNQNEIPLPPTRARDVLMEVQKIKEYRERFKIESRTGGVGTGVSVCMFTFHNTLDCITCIEFSDDHSLIAVGTEESYIRVWSMTGEPLHAILSGENQPTNSRRLIGHSASVYGLSFSPSISGSEEPNSALSTNPKLLLSCSSDKTVRLWSLETWSCLVVFKGHEGPVWDVRWGPFGHYFATCGRDRTIRAWSQDHISFLRLMVGHDTSVNKVAWHPNGAYIFSASDLSDKTVRMWALTTGECVRVFSGHLDFISAIECSPSGKILASADCSGTIILWDIVTGSSIKTCKGHGKGGIWSLSFSVESTLLVSGGADCTVRTWDIEVPTNAHKLAEGEVVSGNNQADNNRTSPSSTVPSGTTTNTSATSGTKKRSKDTTITPDQISTFPTKKTPVYKVKVSRMNLVMASGCYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D0</accession>
    <name>A0A0B1P1D0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative calcium homeostasis endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003723">
        <property type="protein sequence ID" value="KHJ30716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1D0"/>
    <dbReference type="HOGENOM" id="CLU_021915_1_0_1"/>
    <dbReference type="OMA" id="NYQGQWP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="541" mass="60664" checksum="D38B4C903D4BAC67" modified="2015-03-04" version="1">MTSHQLAIAKASLLAGLLRPDPTPVSREESLNFHALLKAVTVKCSPENIQLCKQWTLENIYQSTSRSIALGKYLIAFTASLVESELKNETDSKSKPSIKRQCLHVLYLVNDILYHGKYRINDLLICSKIQPILVSLIGSCASFKGSPKHLSKLKNLILLWKEKNYFTDEFIDSLLLALENALETRKQVELLTDKEKKEGKTILPKPISFTMPASHGDPSTPWYDLPAGNLMPHIIPNSTRPINPDMIKPLQFVSGPADESLVSAVKKLLSDVDEIFTEEQENNEKTLWDIDELGQPIIIDEITGDIIDGEGYYGWSRNFCEKMKKRRNEQNNLRKGNHSEWQERSVNSSPEARKRRYSGSGESPIRSRRRRRSFNSSRSSSISSRSLSSHSRSNSRSRPRSPLRVTPSLEKISKSSPPKDEIPAQSASSQIPPAFQHSLNANFAHSLPLPNMNMSGPNLFGAWPPPIPPPLPFPIDPNLQQFGAWPPVPFPPQPGQMNQHPAPFPYPGPNGWQHVPNSNGHPFEWNGTQPGGHDGNRTRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D9</accession>
    <name>A0A0B1P1D9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g2203</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003828">
        <property type="protein sequence ID" value="KHJ30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1D9"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="OMA" id="ENMPGWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="37"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="368"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="538" mass="61365" checksum="8003B171928C68AE" modified="2015-03-04" version="1">MTTEVFPENNAISPRTFAKQHMRSQSSFRGCSRISNYEQLGKLGEGTFGEVHRARSKKTGAIVALKKILMHHEKDGFPITALREIKLLKLLSHPNVLRLEEMAIEHHKKTSDKKKRAVIYMVTPYMDHDLAGLLENPSIIFTEPQIKCYLMQLLEGLKYLHNNHILHRDMKAANLLINNKGILQIADFGLARHYDEPVPVAGGGGGEAHRDYTVLVVTRWYRPPELLLQLRKYTTAIDLWGVGCVFGEMLIGKPILAGESDANQLKIIFDLVGTPTNENMPNWRSLPGAELYNVSSLPQTTGTLSQNFRTYGSGAISLLKELLKLDWRKRINAIDALNHPYFRNDPLPARPEDLPKFEESHELDRRKFRGQKAALPPAPKGGTVGMGQHGSWEATVVGNEAGTNSDGYHPYRQSNGARYSHHASYRNSKINLPSGTEERRPTWSRSHDRPDARLPPRPPPADYTRGDRSDAYRPRSREFERAPHSSRIRTSTNIDTYIPSYSSDGGRRDDRRSRERDERAMSDRSRNRRRDDRHERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1J6</accession>
    <name>A0A0B1P1J6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01003757">
        <property type="protein sequence ID" value="KHJ30689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1J6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1J6"/>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="58826" checksum="32846F973A22CEBD" modified="2015-03-04" version="1">MARHDNSIVMDYDPRYLVCKVQQRILLKPSISWNPEKQAYKIIQKQKHREDFNDEVAGGRITESLLSTLTIHMADMRMIKTSSFEYIKKLSLLYIYWKAFLLAVVACSPGPGYDTSSSFSYPNEHKKNIPFLVHYLAQKLTRWDAVYFIEISRRGYIFEQEWAFGWGMTRFMALCTLGVRKYIFDSDGLECVVGVLIAHTTHFLSVIVLFALTLKIFIGENLENFAFFTACLHIISPAGIFLSAPYAESPCALLSFIGILTFTKSFSVKLPLTKDFLILTSGALFGIATTFRSNAILNGFLILEEAIRTLLAFRKGFRATKFRHLLATGLAGLFVGSGSLIPQYIAYNEYCAESPTLKRPWCTKAFPSIYQYVQSFYWNVGLFRYWKLSNLPLFLISAPMYCLIFASGIWALNLTITKNFLKNLDSTGGLKINYRYCLIVRNLAISQLILSIVTFTTAHAQIISRTSSSYPVWIWFLTSLLLSQKKSKFEPLVKGLTSYLTTYGIVQAGLFSSFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1N5</accession>
    <name>A0A0B1P1N5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003684">
        <property type="protein sequence ID" value="KHJ30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1N5"/>
    <dbReference type="HOGENOM" id="CLU_1866627_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="137" mass="15656" checksum="46D664C25F42F5E9" modified="2015-03-04" version="1">MKSWAANKNIGLKQTVAFSPGTHKNAERANRTFIEKANNVRFPTNSPAEYGNTMLGRYFLRLPRKNKKILLCLAPKGQNVNKDSDKYFDDKNDGTISRSKGDSHNNQHVQDLEIFDNKYDISSNFMNNLQRESSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P208</accession>
    <name>A0A0B1P208_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative gpi-anchor biosynthesis protein (Pig-f)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002992">
        <property type="protein sequence ID" value="KHJ31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P208"/>
    <dbReference type="STRING" id="52586.A0A0B1P208"/>
    <dbReference type="HOGENOM" id="CLU_069429_1_0_1"/>
    <dbReference type="OMA" id="WQRWPVT"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="271" mass="29784" checksum="1DB889E7A75D1BE5" modified="2015-03-04" version="1">MSSTTTRKTIELKNMNKSGKPGSQSTTIEILPSTLARIFSLAHPFLLLSVYIARFYHLVSDPVGELKNFLIPLILIQITYVVVCLPIAGFSASSSANLSKVGARGKAKSKKAMKSPSRILVRFYLASNLQNYFFTSIQTILFALCLTGTSIPVLAIIQVLFGAPFTSHLLHTILSSTHLSLLSLFPLIYVHGTDSGKWKQILSAYCPMDEVFGATVGAFIGGWLGAIPIPLDWDREWQKWPITIVTGMYLGYISGKFAGGKVFKGKRIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P266</accession>
    <name>A0A0B1P266_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1381</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003318">
        <property type="protein sequence ID" value="KHJ31031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P266"/>
    <dbReference type="STRING" id="52586.A0A0B1P266"/>
    <dbReference type="HOGENOM" id="CLU_006587_3_1_1"/>
    <dbReference type="OMA" id="DMHVSGI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="297"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="488" mass="53062" checksum="3D3EDA61ACC6ED4F" modified="2015-03-04" version="1">MAAKSILEADGKAILNYHLTRAPLIKPSPLPTSTTHNPPPKLASLYFPEDANVMAVLDQAEQSYPWLLAPGAKFVAKPDQLIKRRGKSGLLALNKTWPEAKAWIAARAGKPQQVETVVGILRQFLVEPFVPHPAGTEYYININSQREGDWVLFTHEGGVDVGDVDAKAEKILIPVDLSEYPSNETIASTLLKKVPKGVHNVLVDFITRLYAVYVDCQFTYLEINPLVVIPNAQGTSAEVYFLDLAAKIDQTAEFECGVKWAIARSPAAIGMVAQKNASGKINIDAGPPLEFPAPFGRELSKEESYIAELDAKTGASLKLTILNPKGRVWTLVAGGGASVVYADAIASSGFADELANYGEYSGAPTETQTFHYARTVLDLLLRAPLNPNGKVLFIGGGIANFTNVASTFKGVIKALREVSPSLIEHNVQIWVRRAGPNYQEGLKNIKSVGQELKLKMHVYGPEMHVSGIVPLALIPGEWEKCKVEEFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V7</accession>
    <name>A0A0B1P2V7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative abhydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001941">
        <property type="protein sequence ID" value="KHJ32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2V7"/>
    <dbReference type="HOGENOM" id="CLU_017361_3_0_1"/>
    <dbReference type="OMA" id="ADQHLVM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="510" mass="57844" checksum="B93367AD3BD7AC09" modified="2015-03-04" version="1">MPPNSDTGHQNSLLTAQKLKLSDEDQSKSPYFPLGYKTAAWQWWSNLAPAIAEHRVLSFVPFIQPLSSPTNPGSSKTIPEDLGTANDPYGQRVRYSNIVVLSGNDRSLNEFSVERMGENIEQNLVMLHGYGAGLGFFYKNFEGLSRVKGWKIYALDMLGMGRSSRPPFRIHAKDQVGKIREAESWFIDALEEWRIKRKLEKFTLLGHSMGGYMAIAYALKYPGHINKLILASPVGIPEHPYATHNDISEPKKSALTQEFTESQDETARSKISNKSEAEEKYEFRSQPSEQPTKETASAPVQRKLPKWFSYLWDANISPFSVIRWTGPLGPRLVSGWSSRRFSHLPHSESEALHEYTYSLFRQRGSGEYALAYILAPGAFARDPIIRRIHKVGRQELPPKTTDADPDRSDSKPNNFHKETGFPIIFMYGENDWMDVAGGLAAEQKLKEEKAKILETASEEERRKENGSAKVITINNAGHHLYLDGWEEFNEILRKEMDDTSLHGRRELGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P303</accession>
    <name>A0A0B1P303_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative trimethyllysine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003301">
        <property type="protein sequence ID" value="KHJ31059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P303"/>
    <dbReference type="STRING" id="52586.A0A0B1P303"/>
    <dbReference type="HOGENOM" id="CLU_021859_2_2_1"/>
    <dbReference type="OMA" id="PYVDCQS"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="235"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="491" mass="56518" checksum="DB543B5131F7390A" modified="2015-03-04" version="1">MSYGPPCWRSLTLPSLLTHFRGHIKKNIPHSRNYHYQSSESEGINEEWPLAGEHYHIGGKLTRKHSLQDTSRVHENETRSYGLWGNDAFNFPYKAVTITNVEIDLIFGSGGKLVVNISRLAHTHRDNCQCKKCINLDTLQKSFNIFSVPENIIPNEVVTERGGLKVIWPEGDDLHVSFYPWNWILKKSSLTDGIHKKKLELKSDFYTYWGSEVEYEEPSVCYNEIMSCEKGVGKWTDMIRKYGFCYVDNCPISPKETKRLIERISFIRETHYGGFYDFTSDLSMKDTAYTTIALQPHTDTTYFTDPAGLQMFHLLTHENGSGGASILVDGFKAAKILKLECPQKYKILCSKPVPARTVGNKGITVRPAKTFPVFNLKDLVLGEDEAELYQIRWNNDDRGAFTLEDTISGNVEKWYTAARSFQSIINMSEMQYKTQLKPGRPLIFDNWRILHGRTAFTGKRRICGAYVNHDDYISRWLNTNYPRERILDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P323</accession>
    <name>A0A0B1P323_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2983</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003021">
        <property type="protein sequence ID" value="KHJ31291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P323"/>
    <dbReference type="STRING" id="52586.A0A0B1P323"/>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_1"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="673"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ31291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119462" checksum="B768A2D557AD87ED" modified="2015-03-04" version="1">MLRTKLQLKSRQLLKIGNHGSKYATLQHDPIKPKALSTNLIRPTSYYSCTSSYRRYATSNTSASCQNDNFLSGSASSYIDEMYMAWRTDPKSVHVSWQTYFKNIESGDMPISQAFTPPPTLLPTPTGGVPNFLPGLGMVNGKDSEVTKHLKVQLLVRAYQARGHHKANIDPLGIRREAEEFGYRNPKELRIEHYNFTENDLDDEYTLGPGILPRFKKDGREKMSLREIISTCERIYCGSYGIEYIHIPDREQCDWLRERIEVEQPFRYSIDEKRRILDRLIWSSSFENFLAIKYPNDKRFGLEGCETLVPGMKALIDRSVDFGVKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFGGLAAAEDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRAIQHYNNDEVTHTSAMGVLLHGDAAFAAQGVVYECLGFHSLPAYSTGGTIHLVVNNQIGFTTDPRFARSTAYCTDIAKSIDAPIFHVNADDVEAVNYVCQLAADWRAAFQKDVVIDLVCYRKHGHNETDQPSFTQPLMYKRIQSHQSQIDIYINQLLEDGTFTKEDIEEHRKWVWDTLEESFAKSKDYSPTSKEWTTSAWNGFKSPKELATEVLPHNPTGVPAHTLQHIAETIGTYPENFNIHRNLKRILSNRIKTVKEGTNIDWSTAEALAFGSLVIEGHHVRVSGQDVERGTFSQRHAVFHDQENEKTYTPLQHISKDQGKFVISNSSLSEFGALGFEYGYSLSSPNALVIWEAQFGDFANNAQCIIDQFIASGEVKWMQRSGLVMSLPHGYDGQGPEHSSGRMERYLQLCNEDPRVFPSLQKLERQHQDCNMQIAYMTTPSNLFHILRRQMNRQFRKPLIIFFSKSLLRHPIARSLLEEFTGNSQFKWIIPDPEHGKSINDHSEIDRIILCTGQVYAALQKHRVDNNLRNTAITRIEQLNPFPWQQLKENLDSYINAKTIVWCQEEPLNAGAWSFMQPRIETLLNETNYHDRKHVMYAGRNPSASVATGLKVKHSKEEKEFLQTAFEVTQDKLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3P1</accession>
    <name>A0A0B1P3P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002445">
        <property type="protein sequence ID" value="KHJ31960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3P1"/>
    <dbReference type="HOGENOM" id="CLU_1807661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="143" mass="16948" checksum="D8DBBF8D543E0519" modified="2015-03-04" version="1">MSGLDKVDTDVFAYEPAGQKRVRIDDDSEDDSYRARRAAEANECERHERHERRERHRHQKNSKRKENVVLPTPNHEKRRGDTKLRTIVGREGKGPLDYIKMLENTTITMSMIDFYLASPDFSKSCRTLPTRINEKRTRRKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3S2</accession>
    <name>A0A0B1P3S2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001521">
        <property type="protein sequence ID" value="KHJ33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3S2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3S2"/>
    <dbReference type="HOGENOM" id="CLU_143693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="119" mass="13366" checksum="D44969589D2301A3" modified="2015-03-04" version="1">MIRLGKDHEARKPDFLLIRQQIQQLIPDSTLVSDAWHAPSGIKILASTPAKAAAILQYKDAFARRFGNATLERQASWATFIVGPLPKLIITLDRKQDLIDELFLQEPGLALIRDVVPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P427</accession>
    <name>A0A0B1P427_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dephospho-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002351">
        <property type="protein sequence ID" value="KHJ32090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P427"/>
    <dbReference type="STRING" id="52586.A0A0B1P427"/>
    <dbReference type="HOGENOM" id="CLU_057180_0_1_1"/>
    <dbReference type="OMA" id="RWEMYRA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="32566" checksum="009B650778BD3CD1" modified="2015-03-04" version="1">MLIVGLTGGIATGKSTVSNILSQAPYNIPIIDADIIARHVVNPGTRAYYKIIEHFGPIIPDLLTESSSQSGTSQNHSHSLNDGPKCTENSMAPLNRMALARTIFGNTKESRENRAILNRIVHPEVRLEIIKEVLKKYICGYWMVILDVPLLFESQLDLLCGAVLLVTVRDMNVQMRRLQNRDIHLSSADAEARIQSQADLSAKVRKCLNRGKENGMIIYNDSDIQELNREVERVISQIKRSHPQWWTYLLWIFPPFACCVGFWHLGRSWLLNRQWKLQEDHTKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P483</accession>
    <name>A0A0B1P483_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002867">
        <property type="protein sequence ID" value="KHJ31474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P483"/>
    <dbReference type="HOGENOM" id="CLU_060790_0_0_1"/>
    <dbReference type="OMA" id="GWEAKGW"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="2">
        <location>
            <begin position="182"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="304" mass="34066" checksum="96E3885CFC759BE5" modified="2015-03-04" version="1">MDDGSESSFNEHTEIHLSLQELDPEPAGFYEYDEKSFLPDSPLLPLWSLPFGLSNGNGAGRGSIYYLTKLQKYSSYAFTIFASLHVTNTSFIPLLTQSIDESESYLLLTRPFYQSFPAELLFIGLPIAVHVTAGIVLRLYKRNINLLRYGAFCLPISTRLEKRLKVWPHMSWTSLAGYLMIPLVGSHILINRILPWLYEGGSSGIGLGYVAHSFAKHPLLASINYSLMIGLVTSHISWGFCRWKNLIISGDSQKARRRWWTINSVSAALALGWIIGGIGVVGRGGRANGWVGNEYDNILRHLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D6</accession>
    <name>A0A0B1P4D6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g4768</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4D6"/>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="OMA" id="LYNCNYF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="563" mass="65242" checksum="748AF3BE448576E3" modified="2015-03-04" version="1">MAYLRTKSKSPLVCDDVILTRRQIESLIAEGKKIILVNNYVLKVDAWLKYHPGGEKTILHMIGRDATDEVSVLHSSEAREQMMKYRIGRIEGQWKNFLPPIQGGKFRKVNNDMEIKPEEEPDYSSVTFNALEISRSPSPICENDEIYPRRNVMPSYKSTIPSTRTPDHSIVDLPVKMSVLDCLTKEQLNLDTAKYPSLDAATQEMVVEKYRALHNKLHKEKLFDCNYGAYAVEACRYVFLFALMIICLQKCWYALSGVFLGCLWHQLVFTVHDAGHMGITHNFTYDTLIGIFIADFIGGLSLGWWKRNHNVHHVVTNSPEHDPDIEHLPFFAISHRFFDSLKSSFYERVMSYDAFARLVVPYQAYLYYPILTFGRFNLYFLSWDYLIRGLGPRKGPAWWHRWLEITGQIFFWYWFGYGILYKTILSTSGRLSFVLASHMVTMILHVQITLSHFAMSTAELGPNESFPQKMLRTTMDVDCPQWLDFFHGGLQFQVIHHLFPRMPRHNLRRTQKLVQEYCQEVGIPYAIYGFVKGNKKVIARLEEVGRQAAILMKCQNVIAEKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4K1</accession>
    <name>A0A0B1P4K1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4K1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4K1"/>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OMA" id="GISFPIM"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="33676" checksum="4D5E2B646A913460" modified="2015-03-04" version="1">MTSHRVRKQALNSTNTSPSTVLDQRTTDADNTTLDDSLSDFPSENIFLFWPNVIGYARIVLAIASLYYMPLHPRTCSGLYSVSCLLDALDGYAARFFEESTRFGAVLDMVTDRCTTACLLVFLSSAWPRWALLFQGLISLDLASHYIHMYATLVMGGSETSHKSVDRSRSWILNLYYTNKTVLFIFCALNETFFIALYLLSFSSPYLSPGLLQATNAAGSLSVESAKSFLFANPHSAAALELARANKMDSFVPWLVAGISFPVMLIKQIINVVQLAKASIWLAQGDVEIRKRQGLPRRRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P559</accession>
    <name>A0A0B1P559_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002042">
        <property type="protein sequence ID" value="KHJ32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P559"/>
    <dbReference type="HOGENOM" id="CLU_2559998_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="82" mass="8844" checksum="6E5FE1046F0AC3FB" modified="2015-03-04" version="1">MISDAISTQGAKLEPASDLITYRIATVPFALRTSIGSVTVDDVNLAPEIVRVTNVAPKMARVHGKTRAGAPHRSWLAHIPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P613</accession>
    <name>A0A0B1P613_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001031">
        <property type="protein sequence ID" value="KHJ34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P613"/>
    <dbReference type="STRING" id="52586.A0A0B1P613"/>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="OMA" id="VVGFEVY"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354021" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="25"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="720" mass="80697" checksum="EC24D5CD5E36C12E" modified="2015-03-04" version="1">MAENFLIGLLRSFLFCSIILCSQAFYVPGFSIKSYENNEAVPLLVNKVYSENSQLQYAYYSLPFVCPPSGINHAGSSLLSGQPIPLNLGEVLRGDRIQQSDIELFIGRDFECKFLCNRTVTAPDIKRAKKLIKEGYSVEWIVDNLPGATSFVTVDKSRKYYVPGFKLGYIDLAPVSGKKTYYLNNHLTIVLKYRKASGRDGDKGKKIIIGFEVYTKSVGNVSRDRDGCPIDLENNITSFELEFVQNKTEATTDYLHSSYQPPETESDASYDSENTLDIPYTYSVYWREDDEIEWSHRWDMYFVNQEAGSKVHWLAIINSLIISGLLSGIVALILARTIRADINTGKEFLLENDKFRAKRKIKNGLSPTFKVEKSGLLGQVEDEGNDADISSDEEPLEEQSGWKLLPGDVFRVPSHASLLAHLVGSGTQLFFMANGLLLLSSLGVLNPSLRGGFVSAGVGLFVFAGVFSGYFSGRLYKTFSGLDWKKNALVTALLFPGLLLAFFFILNLFVWAQASSTALPFGTLVGIILLWLCIQLPLVYAGSWYGYTHSGAWKHPTKSTLNPRPIPPQNWYTKNPHSIILSGFIPFAVIFVELAFVFQSLWHERSGSYYLFGFLFIVSIILIITIIEVTIVSVYVKLCSEDYRWWWHSFAVGGGSSIWVFGYCAWYYFTQIKVEGFISGLLFFSYSGIACVAYGLLCGTIGFLTGYTFVRRIYGAIKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P657</accession>
    <name>A0A0B1P657_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">EV44_g4804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001000">
        <property type="protein sequence ID" value="KHJ34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P657"/>
    <dbReference type="STRING" id="52586.A0A0B1P657"/>
    <dbReference type="HOGENOM" id="CLU_035060_0_2_1"/>
    <dbReference type="OMA" id="CSWARTQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="43732" checksum="E338EA6FDB27A0DC" modified="2015-03-04" version="1">MVRHKKDEFSSKKPKKSFHRGHRTKHCTDVANERHSPTSFKAACWDLEHCDPKRCSGKRLMKLGLMRGLHIGQKHSGLVISPNAKEVISPADRQIMEQFGVAVVECSWARTKEVPWNKIGGKSERLLPYLVAANSVNYGKPWRLNCVEALGAAFYICGHPEWAAEILSHFSYGETFLQINSSILKRYAACNDQADVRKTEEAWLARLEKEYSDQRVSEYDNSDELWKNGNFNHREASSDEELDENEGGESNDEVDGIFLGSNSFYSTKKSDEDEQTSALLSDGSCSDDSEDEMVELRKKVLASKPFSGCSVAGKRDKLEKIARPVINSKKESDTESELESDNGNDDEFDSIMNVAPITDRLGLAAKQKAISQAYSSKTSFIGSISSHLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P664</accession>
    <name>A0A0B1P664_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002086">
        <property type="protein sequence ID" value="KHJ32431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P664"/>
    <dbReference type="HOGENOM" id="CLU_1769466_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="147" mass="17377" checksum="580669ACC0DA79EF" modified="2015-03-04" version="1">MSRLNNSRTTKKGNSSGLKRTLSQFFNGLRSCKRNYPTDLSHLHMAELWAEKWELKIEESTQKKRRSKSTCLETIPEEQEYDEELKKAMVNLSTKIQFPDADFVVIGDKSSPLRPKDRIWILRLRLSIMLHFPAFEQLAHKRLWSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P670</accession>
    <name>A0A0B1P670_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pumilio domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000997">
        <property type="protein sequence ID" value="KHJ34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P670"/>
    <dbReference type="STRING" id="52586.A0A0B1P670"/>
    <dbReference type="HOGENOM" id="CLU_013994_1_0_1"/>
    <dbReference type="OMA" id="YGPEFSI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="123"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="757" mass="84701" checksum="D0CE7BF305700AE5" modified="2015-03-04" version="1">MMSTVTVSNSGSSGVKRKSASISHKNTKKSKLAKPDKVKDSENEEKSEKSRSKSNSEKKSKVKSALVKKLYNSKIQKVQKIQKVSEFDSSVETSLGVEKKKTEENFDKNSSLETKNQDGLHPERVKAILQNGQSSREAHAKQKQIAQERKAAKPLADDLVRTKKIWERLRRKSHVPREERKQLVKELFDILTGRVKDFVLKHDSVRVVQTAIKYANPEQKRIIAKELAGSYRQLAESKYAKFLIGKLLVQGDDEIRDIIIPEFFGHVRRLIKHPEASWILDDIYRGAATKSQKAQILRECYGVEFALFQDKELNDVTSVLSEILSHDPGKRETIMNSLMELINQLIQKKMTGFTLLHDAMLQYFLNTKIGTNEATDFLGLLKGEEEDDLLKNLAFTKSGSRLVCLALAHENAKGRKLIMRAFKDTLQMMASDDYGHVIILVAYEVIDDTVFTSKSIFPEILSKDADKQVENAVLSANNLNARTTLLYLFEGRSKALFPISLSSDIKILEEIEDARKLTSKKDSKIRRAELAKELSPYLLKVIEVAASRLIQTSFGCQFVTTVLLEAQGDKSAALHAVAKTAAGNPTSTYLDKIINAPDGSTCDDTSSLTHISSSSYGGKMLRSLLAGGRFNHETKSIMPVVPALDFSNILYPYIRENILQWAIGPASFVILALVESESFSKKQEVLELLKSEKTLLEKASEELRTDEVIQNKILDTVVATSSESKCKNLAKKKSQTGKKSQAGNRGSKLLLNMLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G7</accession>
    <name>A0A0B1P6G7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G7"/>
    <dbReference type="HOGENOM" id="CLU_011743_1_0_1"/>
    <dbReference type="OMA" id="MCYLSEQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="656" mass="74092" checksum="10960AEC63B890A2" modified="2015-03-04" version="1">MPENPKPLLPLTEDLPPVEATNRPKVRRFAIEPIETSIRSSRGGKTTTQLEESSEKKILPKPTHRKHLPVPIETSYHSNRQKRDDKEPPSSSRSKPATTPKGKVVSSKPKTPRKFVPELIETTVRSRRVGDSKPATLPTDKTDITPGVPNIYTSSQTRRQRGILEIPFDRERNEYPTHNLSFNPRRQRSVRPHNNTRCQSSFTSVLESISSSGSGSPSSPSKSQSYQQFFSAQDIASESAFQLSRNRESCDERFSGYILALAAKSARKQLMEKALLLAAYPNESDHQNVEHFYNREIETPSGNGSPGVGDAMDIDIDDDTSDSSIKSRRAFVRRRSSDSLYAIKEMQVHKDKHIKLRREQAAESRLEKFGGFSTQGPFRTRVKKSHASPNRDAVEKELQKMRNVTSPPMLGAGLKFRKCSSPKSTKFETDQKIDLKLTRSKKGGGLWGGYCVAEEPKSIECQDDKRSPLIHTPWSGKSFGNLLEESMAEKMSNFIDVSARGTDDEKNTTMNDRISKNPRLKSSVLTEKENCSEEFDDKFVTQVYNYLSLGYPSLAWQFDEELSRISKIPVEELRRSDESDIKGHIGLRAMSFREDETPVQAVKIESQEKDKSQSCTRWRALKIYILEWSRQNPSLDQAALGPSAWGVTARKGSWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L7</accession>
    <name>A0A0B1P6L7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000945">
        <property type="protein sequence ID" value="KHJ34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L7"/>
    <dbReference type="ESTHER" id="uncne-a0a0b1p6l7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="OMA" id="WGQFTYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="41"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="574" mass="62727" checksum="A5FF8DB4B5C6701F" modified="2015-03-04" version="1">MLPIINVYTILLWKSKVDPQTIAKVRNVDRPGNFVVGIPNPIVDLQYTLHQGTLVESGKYYSFSNIRYAAPPIGNLRFAPPVAPAINRTLNNGEKAAVCAQGSPFWGNLMIKNLMGVGLEQLKKDEEELELLKKSLTIETIYTYQPLDPRTSEDCLFLDVLVPEDVFNSNKSAPVLIWIHAGGYVSGDKTSAGKPLNLLAKAEENGEGIIFVAINYRLGLFGWLSGSTFTSQHGQPNAGLYDQRLALEWVQRNIHLFGGDNKRVTVIGESAGGGSIMHHITAWGLNDPPPFQRAILQSPGYMPVVGDGQQGRTFDLVLSKAQSLISKNIKTVADLKSIHFTVLAALNNVIVAQSAPHGTFTFGPVVDGKYVPKLPGTLLNEGRHAEPLSVMAAHNLDEGYIFTLPYITDQRIDSNIEEIFPDASDAIKSHLINKIWPAIYNESSLYSNPPQRASLAISEIGFSCFSRYTALAFPNSSYAYSFAVPPGFHSYDVPYTFFNGETGNVNITVAETMQSLITNFAKHGDPNGPGVPNFPQYLPGSRMLILSNSSIDDVEVDSAANERCAWLQNAPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M7</accession>
    <name>A0A0B1P6M7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000939">
        <property type="protein sequence ID" value="KHJ34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6M7"/>
    <dbReference type="HOGENOM" id="CLU_050424_1_1_1"/>
    <dbReference type="OMA" id="TVWEVKD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="37178" checksum="F5DBBC9103A38334" modified="2015-03-04" version="1">MGFGDFESICHRSMVPLCSVIGPASAIEGIIRLEASCYPRNIELANTIIFQGAASFMHIAALLMTVIMIIHIRSKFTAVGRKEITSFFYIYMLLSFISLILDSGVVPLGNTFYPYFVAAQAGLISALCMCLLINGFVGFQIYEDGTALSVWLLRTLTFAMFSITFLVATATFKSWAGLSPTKTIGLFVVLYLLSGINIIIYVVSQIVLVTNTLQDRWPLGDIAFGVFFLVLGQLILYFGSNTICNAFQHYLDGLFFATTCNLLAVMMVYKYWDSITREDLEFSVGIKQNNWEVKDSFYDDDPRNTVYQDSDFPNPQYNFPQYPRGSFLGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P729</accession>
    <name>A0A0B1P729_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative te1b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000840">
        <property type="protein sequence ID" value="KHJ34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P729"/>
    <dbReference type="STRING" id="52586.A0A0B1P729"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_3_1"/>
    <dbReference type="OMA" id="FNWGATE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="130" mass="14629" checksum="E95406B2AF1954EF" modified="2015-03-04" version="1">MHRQGWPNSILRWTSSFLRDRRVHVRYLGGITSPKDLTCGIPKDSPISSLLFLLYMAEPMKSGKVRAHFGYADDIGALAIGRTISESLSVAQREVDSLSDWTHSNAVSFDIKKSDVIQFLSHRQDTPINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7L5</accession>
    <name>A0A0B1P7L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001524">
        <property type="protein sequence ID" value="KHJ33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7L5"/>
    <dbReference type="HOGENOM" id="CLU_010595_7_1_1"/>
    <dbReference type="OMA" id="LMYMPLH"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="40698" checksum="09ED07DF43619A35" modified="2015-03-04" version="1">MSDSRMEPKTESKIEDEIQAARVANIDAATEQAEDEIEIDSDNYDTSSDAGYETDGAGSVSTSLSSSVRDYAFENGRRYHRYREGAYNFPNDDLEQEREDMKHAMMVNLCGHRLHYAPIGNNPQNVLDMGTGTGIWAIEMGDLYPSANILGVDLSPIQPEWVPPNVVFMVDDIESPWLKPHDYFEYIHGRHIVMAIKDWPLLMRRAFDHLKPGGWIELQEIHHYPQCDDGSMPANHEVAQFWKVINEGLAALGINFNAAHLLEEMLRDAGFINITCKILHVPIGTWPKNSILKLVGLYWRTILIDGLQPIALGPLTRGLKWSKEQVDVSLIDVRKAYMDSRVHSHMPLYIVWGQKPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P846</accession>
    <name>A0A0B1P846_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative apses transcription factor xbp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001809">
        <property type="protein sequence ID" value="KHJ32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P846"/>
    <dbReference type="STRING" id="52586.A0A0B1P846"/>
    <dbReference type="HOGENOM" id="CLU_027582_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="461" mass="51592" checksum="1B948E80D8537F4F" modified="2015-03-04" version="1">MLSVASLLNPVKSDKKKMSSSPSRPNFCVPKSSPLKFSTTIKKQEPKKFEMTIPKAKINGDVCYPPFEDLDEQTLQSVRRFQINPLGKIKENSRHIPYNSGKNNFLEKTGRESFEVFCYDFRIPGESKDYTVMWDYNIGLVRITPFFKCCNYTKTTPAKMLAQNYGLRDITHSITGGALMAQGYWMPFNCARDLCATFCHHIASALIPIFGPSFPSICIHPEAPEYGRMIISSKTIAEAAIQAKKSCSLMFAAREIVSTYSRGNSHRLSAENDSSLLNKNYNLLDKQNSGSSQLAETAESFNPHFLSASNPLAKKLYARETFDSYLIMDTNVPSHFSPLKRSHSFLTDISNLQIMPSLNAREQTDVKKNRANKRKTISGTCSGEIRNFSIEKAALSAKEENSTSVSSAKTIDSNSEISSRSEEAKAALSLINLRLKYHTVSYEEAEIGTEPHANRRRATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8J0</accession>
    <name>A0A0B1P8J0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative copper resistance protein crd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000815">
        <property type="protein sequence ID" value="KHJ34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8J0"/>
    <dbReference type="HOGENOM" id="CLU_133919_0_0_1"/>
    <dbReference type="OMA" id="CTCEKAT"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="106" mass="11323" checksum="0EF612C316059E13" modified="2015-03-04" version="1">MGLSTCCRRNGETCLCATQAKCSCGKKSALRCDCDKAQTENSIRGPRCSCRARPARACTCERAHIENSSPEGNLCPCGIRPADSCSCEEAKDGGLLPSEIDFTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Q1</accession>
    <name>A0A0B1P8Q1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Q1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Q1"/>
    <dbReference type="HOGENOM" id="CLU_015599_1_0_1"/>
    <dbReference type="OMA" id="ARIPECH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="245"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="599" mass="67964" checksum="E49B59D0C9CE1C96" modified="2015-03-04" version="1">MKISFPILRNPTSTYPKLSPLPETIITTDEFFAALCQSRGRLGVSDNEEWQQKKMGLAISGGVDSMALAFLCSNLQLYELPNYRRLKFHGFIIDHGVREGSEREALSVAKILANRGIPASIWKIKWQVRHPHLLPNFESLARKHRYRLLGKACFENKIDSLILGHHEDDQAELIMMRIIAGHRGRGLMGMKSRSAIPECYGIYGVHESGGGMIGSDINCQYSPPISKSILKISSNQAWQQNQNKVKLLEETGGIQIYRPLLNISKTRLVSTCEAYQIPWFEDKSNHNAKFTQRNTIRHLFRCHTIPDALSKPSLIKLAKRISINVQRLEQDVNRHLSKLYICSFDSASGTIKVEFPNFINEKRLADSEYLRLFQIAAEILRKVISLVTPQEHVELSSLQTSVTRIFPELLNKTPIIYSPPSKSPQVTNFTVAGVLFQPISLIATPSQSLHVSDKCIWLISRQPVPRLYFHNHIYTIPATQENNPPILFDGRFWIKIKNTSQSHNLILRFFEAADLKLFISQFKSLEKAIIIKKLSKLAPGNIRWTLPIICARQIAATSSNPFQPLSLPSLKIDVPGASAFGAWQTHYKKIYTDHMNIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U6</accession>
    <name>A0A0B1P8U6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blumeria specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001491">
        <property type="protein sequence ID" value="KHJ33341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8U6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8U6"/>
    <dbReference type="HOGENOM" id="CLU_325160_0_0_1"/>
    <dbReference type="OMA" id="DIMAMEE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="941" mass="106633" checksum="3A511F88FB318DF0" modified="2015-03-04" version="1">MATHLTGQYSPSSRKNSPSRYNSQNYHPSTKLPQSARDHHGDRSLPSRRYPQYEHEPDDHNVANRQSIPPPSHRANLTSTSPHTGNSSIIDRSELRASSETMKNPRPINSNTSNDITGSEDLKKKQEDIFKNILEVVTDISSLKVENKKAIVLFETSKEKYERTTCHHSRFPNLKTTLQNELDKAKESVEKINEELCRRDVTLRELAGQSLPILLPAIQAYRNESNQKPEDPKILEKLENVISKSEQQYSDLKQELGRFKEEQRKYQTLKDKQLATQETQLKVIKSTQLEKEKLLASQEIQLKEIKSSQQEKDSEIAKLRSQLRTLNDELSILRKEKLDTLGQIELVRDKFNSTHKETIRISAHLAETIGKNLEKFKSFESQFQSLASVKSGFKMLRDNGLLDLKASTVEDISTTLKVAVGRIDSLPSAASYFSLNSRLETLEKEINSEPHKKEIIDLLGLQIQNRLIALENEVVKNQEINSESVKKEITELLGLQIQNRLIAIENEVAKKKESPASSEIAISTVEEKIDALSKKFMENSNPSKTEEELQNLRVLIGELQRSLNIVRINVAGLHERTQSATNQSYDDTKMERMVEVKTRKFVAETFRKISEVSQMLAATNHSVENLMSRVDNVTTGHLAQAILNQLSETYPHIQTVEQLYITQGKQLRDLQSKVDNLSDVKADFLALNQSTISTGNNFRNLGNEVDKISEDIFKTNQNIKKLTTALEDERKSIIECLTSKLDGLVSSDNLHTYKTQLDTQIQTLVEKCVEEYTKKTIVPQLDKASTSLDIEAFNKYKSGIESSLVMVEKNASKISEIEDKISSMRAEIVNRVTNKFQEQNGGLSELIATHVDRSFATKKPDFVKEVTKYLELKESSISRSTHNSPSHVPSNKTTEKNSLSPNSSQKSKRKFHDIKSESSHRSGSPTNKSIGNKKNRLNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8W9</accession>
    <name>A0A0B1P8W9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001478">
        <property type="protein sequence ID" value="KHJ33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8W9"/>
    <dbReference type="HOGENOM" id="CLU_151460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="130" mass="14590" checksum="202A4E44BD2A9129" modified="2015-03-04" version="1">MPSIRYVKHDPVIAVPRKFPPALVEVDPAKSKSSPSRGAGVNAQYALHVWDSQEDSHNPFLQDPHSSSRVSIVFVSISLSPLRLFFTKPPHDWPREYRVKGSILSQRASDEIKLLAQMVGCWLDVLEVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Y7</accession>
    <name>A0A0B1P8Y7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="9" type="ORF">EV44_g1450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001454">
        <property type="protein sequence ID" value="KHJ33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Y7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Y7"/>
    <dbReference type="HOGENOM" id="CLU_058171_0_1_1"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="8">
        <location>
            <begin position="205"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="32330" checksum="FF640B52C7C85977" modified="2015-03-04" version="1">MSPSNLPPIFNATTQDIEMLLSAQCHIGAKNLQVHMDGYLWKTRPDGVNIINIGKTWEKIVLAARIIAAIDNPADICVISARSYGQRAVLKFAAHTGAVAIAGRFTPGNFTNYITRSFKEPRLIVVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAVGLIWWMLAREVLRLRGSLATRETEWDVMVDLYFYRDPETEENKEAIEEKVPDVEVGTSINDPTAFAAGNADWEVSAATNSGFVGAATNVPGAPAGISWDGAADGADWGAGAAGEWGASEVKVTEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P905</accession>
    <name>A0A0B1P905_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001601">
        <property type="protein sequence ID" value="KHJ33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P905"/>
    <dbReference type="STRING" id="52586.A0A0B1P905"/>
    <dbReference type="HOGENOM" id="CLU_2359737_0_0_1"/>
    <dbReference type="OMA" id="HDADCSH"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="84" mass="9282" checksum="24C591ED6568EB4E" modified="2015-03-04" version="1">MGKGPRFAIYDFNYELSSGEGSRNKIVFISWSPDDAAIQAKMIYASSKDGLKRALEGIASEFQANDEDEIEYQSVLKNISKGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P981</accession>
    <name>A0A0B1P981_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="13" type="ORF">EV44_g0046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P981"/>
    <dbReference type="STRING" id="52586.A0A0B1P981"/>
    <dbReference type="HOGENOM" id="CLU_018195_3_1_1"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="131"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="343"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="459" mass="50675" checksum="08870A62D6D78CED" modified="2015-03-04" version="1">MSIPGLGQAVSVTALSVTSPESVPVIHEIQANSEWRFDIAVDQNIQVRILSGTAEIFGTEIALNHIYKFQGIKSSIFTWHGCRIEVKGECEEYTAEETPMIQYANTHFALEKLREKAEESSNDGPRVLVVGPSNAGKTSLVKILTAYALRMGRKPMVINTDSKEGLLSIPGTMTAVPFASILDVEQGWGSSSTSTTSPVPAKLPLCYYYGLESPEDNTKLYKPLLTRLALAATSRMTDDTDVNVSGMIIDTPGVISQGKGGYDLISHIVSEFSVNIILVLGSERLHSELHRRFSSLKTNTGESITLIKLDKSGGCVDRDEEYLRQSRECSIKEYFFGVPNSTLSPHTLQINFDEVFIYRIKEINSLSFMPGGEEIFDQELYEKIEPNLSMMNCILAVMYASGADSQETIRDASVMGFVYVSEVNQKKGKLKVLAPMNSKITERPLIWGSWPEPTVSIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P982</accession>
    <name>A0A0B1P982_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative catabolite repression protein crec</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001564">
        <property type="protein sequence ID" value="KHJ33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P982"/>
    <dbReference type="STRING" id="52586.A0A0B1P982"/>
    <dbReference type="HOGENOM" id="CLU_016971_1_1_1"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="621" mass="68914" checksum="7ADD2CBC146AEF28" modified="2015-03-04" version="1">MFVHPPTTRYPSQSAAYNTATSNGQTTFPMVENYNTLSHPFGQQYQLVVGEGTYILKDDLHIATPPPHPLETHVIAPNPLATTPQPATAGMKVSLLQLETPNLSPVTTASSGLSRQRVSSAENSEEIPSEIHELPENIQGSSEDGGTSSAGSVKQGLSCGPSPAFGEGNNMLSVNVKDSGKKKKPKNNIAKSNSSFISRCIVHENLAKRLNERQHNGYFAFANINRAFEWFDLSSPQKAEFLTKILFAKSHCLCHDINNVTKSQHHIDIIMGFSSGEIIWYEPISQKYTRLNKKGIINQHAVSEIRWIPGSDSLFLAAHTDGSLVVYDKEKDDAAFMSEGSETSINGQSSHQEGNSEQILHVDKSVHSKNQKFNPVSIWKFSNQRINAFAFSPDNRHLAVVCEGGTLRIVDYLKEKLLGNFSSYYGGFICVCWSPDGKYILTGGQDDLVSIWSFSEYRIVARCQGHHSWVTAVSFDPWRCDDSNYRFGSVGEDCRLLLWDFSVGILHRPKSKAVRLRGSVCSWYPGLYRAETNGSKIRTNSVASVHDDYADTIDHAAEPRSTTATLPPVMSKVIHDDPLCWLEFTKESILTSCRSGHLRTWDRPQNVTRRSVANKINSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D8</accession>
    <name>A0A0B1P9D8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000645">
        <property type="protein sequence ID" value="KHJ34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D8"/>
    <dbReference type="HOGENOM" id="CLU_090424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28137" checksum="C12B4FA1E512631B" modified="2015-03-04" version="1">MAIANFAAVENSPAPPQIPSHTRSNKSGGYGSANGKNGLKKVAIATPRAPMGVAAKIGKIYEAPSLPKIPKMTENTWATVTINGQKKARVTPSTKTQAAPAGTKKDKSGIRSPPNKDPSDKRLFVRLPVDHEWRKLSPAGIREVIVKKLSISPTLIGKIKPVHSGFALSPCSSEARENILKAGNGLFLTGAKLEPATNWVPILVPTVPATIFMEHGKVEITKSMLSDEIERVCSIRPSHLKLYGRNKPEAPHRTWMAYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9E0</accession>
    <name>A0A0B1P9E0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000642">
        <property type="protein sequence ID" value="KHJ34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9E0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9E0"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="67"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="553" mass="60313" checksum="1ED79EB2347EC8DC" modified="2015-03-04" version="1">MLLNYNTVFKQLSPKLNHSLLANRLHVLSKWMTSSPSTLAYTKFNYPITHSIIQDVKDTPWFIDNKFVKSEATQFFDVHDPATNNLVTRVPQNTDAELQASVESAKKAFRTWKSFSVMARQQIMFKFTQGIRDNWDRLAASITLEQGKTLDDARADVFRGLQVAENSCNIPQQMIGEVLEVAKNMETKCYREPLGIVAAICPFNFPAMIPLWSIPIATAAGNCLILKPSERDPGAAMILAEIARDSGFPDGVLNIIHGSSKTVNFIIEEPHIKAISFVGSNQAGEYIFANGSAKGKRVQSNLGAKNHAVTLPDADKLHALNSIVGAAFGAAGQRCMALSTLVMVGSTQSWYADLVKLAKSLKVDGGFEKNVDLGPVISPASKKRIEDLISSAENEGATILLDGRNFKSKKYPGGNWVGPTIITNVKKHMECYRQEIFGPVLVCLDVDSLEEAVSLINDNDYGNGVALFTRSGSAAATFQKKINVGQIGINVPIPVPLPMFSFTGNKKSIAGGGASNFYGKRGLDFYTQLKTVTSLWKDEDVVDQVAAVAMPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9E1</accession>
    <name>A0A0B1P9E1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001346">
        <property type="protein sequence ID" value="KHJ33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9E1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9E1"/>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="OMA" id="RAKPKAW"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="366" mass="39260" checksum="DA19B256DEE260C7" modified="2015-03-04" version="1">MSASSTTQPLLTASPQKLRTPATDLLKINHPILLAGMNVAAGPRLAAAVTNAGGLGVLGGIGYTPQMLRDQINELKIFLIDKSAPFGVDLLLPQVGGSARKTNYDYTKGKLDELITIIIESGAKLFVSAVGVPPQHVVDRLHAAGILYMNMIGHPKHVNKCLNLGVDIICAQGGEGGGHTGDIPTTVLIPAVVKLCKDKFSPMSRKPVQVIAAGGIYNGQTVAAALMLGASAVWVGTRFILTDEAGASKAHQEAVRTSGFDDNVRTIIFTGRPLRVRTNAYIQDWEENRTAEIKELTKKGIIPVEHEMENLPDDVDEEKLDQMRPFLMGKAAAVVDEKKSAKDLVDELVNDAVYWIQKGGKMVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9E2</accession>
    <name>A0A0B1P9E2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001538">
        <property type="protein sequence ID" value="KHJ33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9E2"/>
    <dbReference type="HOGENOM" id="CLU_1070365_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28945" checksum="36A96CA12E8D6A0D" modified="2015-03-04" version="1">MLQLIFDISCLICSSILNLLIFIVKGEPLWAQVGVVKEITQKSDERKIDVSNGKIVIGVKRLKDKSGYQILRVPELLKSSRLRKNRGEISGPSPNHNYSSSPSFHSAIGSQKVGSMNREKKSNAGLKSRSTTAFIRSQKIDGNSRNTKKTTLITNVKTSLDSKGGRPSMQQHENQYYTSFKTSSSTMNYKIQSSSPLQISSFTNTRPSQSATVHNSTSSVTTNSKKTIPTKKTIKFRHYERSIGHSPMDRQGHCARCFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9E6</accession>
    <name>A0A0B1P9E6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000636">
        <property type="protein sequence ID" value="KHJ34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9E6"/>
    <dbReference type="HOGENOM" id="CLU_003016_0_0_1"/>
    <dbReference type="OMA" id="NYINWYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="159"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="895" mass="103683" checksum="F22EC83E9B6BB99D" modified="2015-03-04" version="1">MGTHHEIVSENGGICQMYRFNLYETATCYYIVGSDVMDKKFRILKLSRTGDDGDLTITEDEVIYPKNEMTQMLNTIDVSSKNTGGIKLRCSTWGLLGFIQFTGAYYMLIVTKRSQRAMIGGHYIYSIDGTEIIPLTTGIKSRFKSEARTPEEARFLSILNNLDLTRSFYFSYSYDITRTLQHNIITERTSIAQGNPFPHNQDYNSMFVWNYNLLKPCLDKFKCTYSWCLPVIHGYIDQSVLYIYGRTVFITLIARRSRYFAGARFLKRGANDRGYVANDVETEQIVSEVLTTSFHAPGPKLYSNPNYTSYVQHRGSIPLYWTQDNTGVTPKPPIELNLVDPFYTAAALHFDNLFERYGTPIYVLNLVKSRERMPRESKLLHEFTEAINYLNQFLTVDQKIIHKAWDMSRASKNQDQDVIGTLESIAEDVVTKTGFFHNGDGKTTPTMVQNGVARTNCIDCLDRTNAAQFVIGKRALGHQLHALGIITGTYLAYDTDALNLFTHMYHDHGDTIAVQYGGSQLVNTMETYRKINQWTSHSRDMVESFKRYYNNSFLDGQRQEAYNLFLGNYKFELGKPLLWDLPTDYYLHHTNPRLWSSRIRRSYINWYTPKFLEKRTLPDYVTPPDYDNYKLLCYLNDYWLEYYKPLALSSLKFIYSYTGKMNSTLRYISIRPTQGPYNFSPFTVRTNFDHELKRLKKEVTITNTIHESKQIIDDDTTSTRSEAIMSNKRISLQRWLQPIQDRSQTNRVIKESQAHDVNQKATALDKGRAAQWTFTQVVQESLNPNVSPPEADDYAYYILHPQTLPLVVSTETPTDIDSEYLDYVNKNWQDIGAMKILEEKDVNESVLDDMVEYKAFLTVAKNPLTVTADDLNKKRYKAYQKWLMGKSLFKEQPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9K8</accession>
    <name>A0A0B1P9K8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001513">
        <property type="protein sequence ID" value="KHJ33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9K8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9K8"/>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="724"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="837" mass="92926" checksum="9300E0233B682D2A" modified="2015-03-04" version="1">MVKFVSKQNVKLFIRNVRASKTIADERAVIQKESAAIRASFREESGDSNVRRNNVAKLLYLFTLGERTHFGQIECLKLLASPRFADKRLGYLGTMLLLDENQEVLTLVTNSLKNDLNHSNQYIVGLALCTLGNIASIEMSRDLFPEIENLLSTANPYIRKKAALCAMRICKKVPDLQEHFFEKAETLISDRNHGVLLCGLTLVTSLCEADIEADEEGEENIVEKFRPLTGSLVQTLKALASSGYAPEHDVIGITDPFLQVKILQLLRVLARGDPETSEQINDILAQVATNTDSTKNVGNSILYEAVLTILDIEADSGLRVLGVNILGKFLSNRDNNIRYVALNTLIKVVAVEPNAVQRHRNTILECLRDPDISIRRRALDLSFTLINESNVRLLIRELLAFLEVADSEFKPIMTSQIGIAADRFSPNTRWHIDTMLRVLSLAGNYVKEQILSSFIRLIATTPEFQTYAVQKLYTSLKKDITQEGLTLAGTWCIGEYADALLSGAQYDKEEPINEIKEKDVVDLFSSILNSSYATLIITEYITTSMMKLTTRFSDPAQIDRIRRILHNNTTSLDVEVQQRAVEYGNLFGYDAIRRGVLEKMPPPQIKEQSRVLGEALKKSNKASHRKSKSIKPIEQDLLFDLMGDVNAPTANLGANLGKNSSQNNTDLLADILNSTDAPTVSSIPQVSNVSSIMDLFGGPGASQNHSHTTTTSADIISDVSLSPNNIPTYSCYEKNELQLTFLLQRNSEGTVQVLAKFKNISPISSISNLILQAAVPKTQKLQLHAISNTNLLPGTEASQLMKIMGSKGPPLRLRLKIAYLHTSIGQVQDQVDWSEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA07</accession>
    <name>A0A0B1PA07_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA07"/>
    <dbReference type="STRING" id="52586.A0A0B1PA07"/>
    <dbReference type="HOGENOM" id="CLU_054412_0_0_1"/>
    <dbReference type="OMA" id="WTENKDA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="345" mass="38691" checksum="9CE9E304E1E68A50" modified="2015-03-04" version="1">MDKIQFNSNFQTSIRTFFQPSQSKKSTTSAVTTLGSSSGTKPGVLGVISHNTTSINLELMSQKCSPSNISSNASIIEVEEDHLQPLRRINALLLPISFPDSFYRKILSPDPPISFSRSIIWSDPEPKVVGGILCRIDPTSCPIFSTERPQDLQGANDIYILSLTLLSPFRGQGLATQALRAVIDVARKHKDLNITSLYAHVWTENKDALKWYFDQGFQRGESVIHGYYRTLKPDTAWILRRRLTPTDYLTTSFSTLKEVDVELTVPPARFPKTSSHTESNAHPPARSFQGKGPDQEWNDLPDDVVHSSQPRLDRNQGDSTRSKNKVKSHSKSKKKRVYPVSAYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA17</accession>
    <name>A0A0B1PA17_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative succinate dehydrogenase cytochrome b560 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2241</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA17"/>
    <dbReference type="STRING" id="52586.A0A0B1PA17"/>
    <dbReference type="HOGENOM" id="CLU_094691_0_2_1"/>
    <dbReference type="OMA" id="MNGIRHL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="187" mass="20656" checksum="D45D8211D282A3E4" modified="2015-03-04" version="1">MLSQRIGQQSFQRTLRSLRASHIAGTQVQVPITLGSIYLKRNIETHRIKSSESYEILVAQRKKRPTSPHLTIYRPQITWYLSALNRITGCLISGGFYTFGAAYLVSSLLGWHMNSAFLATAFGALPLALKLGIKTLVALPFTFHSINGVRHLVWDMGKAFTNKAVIRTGWMVVGLSISSALALVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA20</accession>
    <name>A0A0B1PA20_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative vhs domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001000">
        <property type="protein sequence ID" value="KHJ34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA20"/>
    <dbReference type="STRING" id="52586.A0A0B1PA20"/>
    <dbReference type="HOGENOM" id="CLU_017092_0_0_1"/>
    <dbReference type="OMA" id="PDNYEPN"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="9">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="11">
        <location>
            <begin position="195"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="10">
        <location>
            <begin position="509"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="629" mass="69230" checksum="C940BCDA21B127CA" modified="2015-03-04" version="1">MEAASARMAVRDRISTTGDVGSSTLQRYIKQACSLENFEPNLALNLEIADLINSKKGNAPREAAMTIVNYINHRNPNVSLLALDLLDICVKNCGYPFQLQISMKEFLNELVRRFPERPPLRPTRVQLKILEAIEEWRGTICQTSRYKDDLGYIRDMHRLLSYKGYVFPEVKREDAAVLNPSDALKSAEEMEEEERAAQSAKLQELIRRGGPEDLQEANRLMKIMAGYDTRMKTDYRAKAAEEVGKVQQKAKLLEERLESFKPGDTMTEGDVFDELAAALQSAHPKIQKMCEEESDDHEAVAKLFEINDSINRTVERYKLMKKGDIAEASKIAKGTLGTSTGVNSHNELSLIDLDGDDEIKTSVPMPQNNGLANDLLGLSLGDDNDFNSGSSYVPNPISGTNTASYTANPARPPLPPLKQDTVLSIFGPSQPPSSSTNRLTSLQPQSKYIPPHSSRAFPTPVAPSTTNTSVPSIFDFSSDELATLSTQPAFVAPVDDEEWAFESALPESLPSSNTLKISQTALTISLHATRLPYSQNEITISLSFSNTTSEAITELTFMAAVTKGHHLKLQPQSGRTLQPREQNGVTQVITLMGAEQGKGDAVRLRWKASYRVGARPVSEQGEVASLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA63</accession>
    <name>A0A0B1PA63_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ring finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000986">
        <property type="protein sequence ID" value="KHJ34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA63"/>
    <dbReference type="STRING" id="52586.A0A0B1PA63"/>
    <dbReference type="HOGENOM" id="CLU_017097_0_0_1"/>
    <dbReference type="OMA" id="IQIEVFR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="299"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="682" mass="79208" checksum="560D8BBD56A79D09" modified="2015-03-04" version="1">MGMPAAAQHDFSLFGLFQTSGSRRRQRNQLNLQGRDKFSLSNTFEQQQEPGNTPVAQKSTCNQHDCHKQFDEETELKELNFCLEMLAAIFPDIKIGVFREMLLNCDKESRLAVVTEALLQQKSEWLKGRYKPASQNTRLNPQEDKISTLDRGQVPVQEKFRSSNYKRSVMEVTYQEFKGLSRSTINEILADYNYSYTHARPTLLALSSKTWRFSLSTLFKRRKPISSSDISCHPLLVWQPIGQESLNPTLKKSGCAELDQELLESLFDPFKKQVIAEQEEKDYRIASEINTAEAEKNGSLHDCECCFTASSFEELAACEEGHFICFQCIKNSLQEAIYSNGWQRLINLERGSLRCIAATSDECFNTIPIYLVRRALEKEKTGKNLLRRLDERLAEENILKSNLPLIRCPFCNYAEVDELYIPRLKKSCRLNLRPFSFKTVLILLLGVLMIPFLFLQLLSHFLFPSNQSLSKYIVGQFNSSTSRIRRKYIGLKFRCMNKLCGRVTCRFCFKEWSDIHICHESSLQDLRTFVELAMSDAIKRTCPRCNTSFVKTSGCNKLTCVCGYQMCYICRKDIGNGEGYRHFCEHFRPTGGKSCTECMKCDLYRCEEDEVVARKAKREAEKQWMKKEERLLNCDEKLRRILEQKWKQVGDTSSLENKRWNWKFPKKEFILDMIVESIIFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA67</accession>
    <name>A0A0B1PA67_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative rna recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000334">
        <property type="protein sequence ID" value="KHJ35597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA67"/>
    <dbReference type="STRING" id="52586.A0A0B1PA67"/>
    <dbReference type="HOGENOM" id="CLU_050438_7_0_1"/>
    <dbReference type="OMA" id="RAKEECQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="33002" checksum="FAB2F2E5A0CB9F6E" modified="2015-03-04" version="1">MDYENENGARYEEENSRYEHDRSASPRPRRHESPRDHNRRSASPSGNGHVDSRGPPKGDSRSGQDDGAINPGSNLFVTGIHPRLSEQDVTRLFEKYGDVEKCQIMLDPHTKESRGFGFVKMVTADQADAAKEGLQGEVIEGRTLSIEKARRSRPRTPTPGKYHGPPKREDPRSSGRYNDRYDDRRRGGYGGGRDDYRGGGGYRRDDRDRGYGGRDRDEYLPRGGDRYARDDRYGGRGIDDRRGGGGYSDRYDRGDRGSGRDAPSATTYGEPAPRREGREPYGGGDRRYRKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA70</accession>
    <name>A0A0B1PA70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001227">
        <property type="protein sequence ID" value="KHJ33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA70"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10911" checksum="F89ACE9F7D014FE3" modified="2015-03-04" version="1">MAATRCRNFGGPHRSDSQRCLARPSRSGISTKHQLKTFRQVGEREYQAVLRAKAAEESAACDEKIDIDLTSSQGSEIDFNTDDIQASPVENSTGRALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA95</accession>
    <name>A0A0B1PA95_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ph domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001345">
        <property type="protein sequence ID" value="KHJ33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA95"/>
    <dbReference type="STRING" id="52586.A0A0B1PA95"/>
    <dbReference type="HOGENOM" id="CLU_037393_1_0_1"/>
    <dbReference type="OMA" id="SWKPAYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="305"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="47244" checksum="D749DBD5467A59A0" modified="2015-03-04" version="1">MAALQGTIHQDQATFNSNILKPLNFNEPHTQRGVPSLSLVVGRPRNSILDLDITSPVNQNGSFEFDRVIKSGLVQKRTRKTKAWKSIFLVLRPYSLSIYKNQREDKLRHKIHLSDLTAVTLLKDPKNKRQHIFGLFSPSRNYHLQAQSWADVKEWVDLIRKESRVEEEEEEIFLCSPTSNATSNLFASSVIDKTMRNKIEIRRSIDGRRESSSPEPTDSTDQTRKNGANDTIDPRKPSYVVEYSGNEVASHSDWSDAELSKVKGPQQSSVIEKNLSLKPPRSSALLGTRNLDQKRGLHAEQELERVVWQGYLLWLRSRGGVRQWKNMWVVIRCKSITCYKDESEYLPSIIIPLSSIINAVEIDPMSKTKNLCLQIITDEKSFRFCAQSEDILDKSLGAIKSLIAQRRETTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA96</accession>
    <name>A0A0B1PA96_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001187">
        <property type="protein sequence ID" value="KHJ33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA96"/>
    <dbReference type="STRING" id="52586.A0A0B1PA96"/>
    <dbReference type="HOGENOM" id="CLU_007683_0_2_1"/>
    <dbReference type="OMA" id="DQTVIHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="157"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="534"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="848" mass="96811" checksum="F4658DBBC0412DF4" modified="2015-03-04" version="1">MGKLFNLGSKLKYPLTIGRLLKSPGDEIHKQEPIMQFKFTWKQKVGDPFGEEWEEDQTTIADWDSPTDGHIKLWKVHEGMIIEKDTPFVEIEESCLHAVQYFGLCCFCGKDMTLVTWASANDDTVYAKINMIHNQTSLTISEDEASKAEKELQIRLLKNRKLSLVVDLDQTIIHACIEPTIGEWQNDPTCPNYEAVKEVRSFQLNDDWPRGVTSGCWYYIKMRPGLKKFLNKISEMYELHVYTMGTRAYAMNIAKIVDPEKKLFGDRIISRDENGSITTKSLSRLFPVSTKMVVIIDDRADVWPKNRPNLVKVVPYDFFLGIGDINSSFLPKREEIFKIIDSPKKDNIVFDNKKSTEQGEIISITEDIDKPETNDDNKVLDQSENNDSQKILKADALEELLSMGGGGGEDEARRLQQTVEQEKLLEKQFKERPLLQMQEKLDKEETEEEEQSKVELSSNIEQNVHNKHNLLKDDDVELEYLEKHLTQLHRVFYEEYDKAIIKAGYRNSVKGNNPNYNVPDLNIVPDIGNVLPKLKARTFDGCVIATAGLFIFNEELLKLKTDFGARVVHNVSRSCTHLVVSSDSPCSDEVRQALKYSHIKIVNKDWLRDSINKWEKEDEMPYLIHFGKESALDEPIQDELAMLSTQPSDDDGPSITGDETYLLTSTSQNEGTDRENVVKSKVKVDSQTNGLGSIDWRVVDEELAEFMSEEDFENDSDTLESMTIKRGYEEMTDNEESESESSLFKKQKITNERRSGLNEVVTLDQDYAIENKSLTTPKIFIDGEEISDQIEVTKNETLEGHSCDEDSDLEALLMAEFEREEAEEITNPDQDEKITGEGNSNVLTISGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAN7</accession>
    <name>A0A0B1PAN7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000892">
        <property type="protein sequence ID" value="KHJ34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAN7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAN7"/>
    <dbReference type="HOGENOM" id="CLU_575142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="54032" checksum="C6938FFEB83201E2" modified="2015-03-04" version="1">MEKLPDFDYYNVLGVSNKATSTEIRTAYRKLILKCHPDKIQDASLRAVKQVEFQKVQEAYENLCEDKSRREYDELLKKIEIRRQMSQGKPTPWSNPFEYEIKTPGTPNFKVYMYKNTTNGATEGVKFSKGTPGQSNSGPDLRRSSRSESTKAESVKAESQKKKAREEEIRKVKAEIKRKQKEMEENRKKKEEEAKQRHKEKEEAKRRLARKKEKERKEKRTRNSFVDVYEVSDDEYRTPRSSEKKPGQNKSTQEVPMNKKWTGHQDYAGAYVHASLKKSDIPNTPSPSGSYGVRFTKSSDNTPRVSRDKKQSPETPSPLSGRKPSLKSQTSAPPLFRTTSTRRRSQESTVYSKGPSSMPKAQTFSGPSSSTAIPNLSSFSYLSVSNNTYTPGYNALNRSFSSGYYPADHCHVSFATHIQASSTESSAHRASFSSYNTSHNIKMLSADNVNYSPRYGYEHVNFASHSIHYASPGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY4</accession>
    <name>A0A0B1PAY4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative smc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000410">
        <property type="protein sequence ID" value="KHJ35413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY4"/>
    <dbReference type="HOGENOM" id="CLU_010168_0_0_1"/>
    <dbReference type="OMA" id="FSEMPGI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="692" mass="76864" checksum="6FB1BDFCCF5933DE" modified="2015-03-04" version="1">MASPLSELKATSLNVVLSENNSRNKSLDPTKMNSCETGSNQLLSNSTENSTITYESENATPTEYASRSQKPISDHESLSSVRLPSSRPPSISLKNFELSRSPRKLSSPDRRFPVKPYSPPKQSPAAQSPSIEDVLQNNEGISKFLETSEGKNGEIEEDRSSDDTRSSGKRTLVADYDSSNMDDTMISTFSSFSAVPEPTMFSKLRQNTNANNENNATQKSQMTPATSRRPITKPLYEKSREEGYTTNLLEFTGELEKYSDGILSPAKIGRHYAKPNMRSLDLSLVTSPTVKRHTMSNLLDFDIPPAPTPRSLPTITPRELESLKSGFLCEISSLKASLSGKEAEVQSLKSAVGDAEKRVGESLQQFREEQSHRQQLAADKEDWEKRGLEMETLLRSLQEQILLSEQNREELEGRLAESDARRHAAELMAQEAESRVAALRAGRSSPESEIKSQGAVTEGKLVEVAVENVSKELHALYKDKHEAKVAALKKSYERRWDKRVHELEKQVEDLIKENKELKVDRNDKIIGAMSNPNDQSTEKIKELEIKIEITQTENTELQKFLNKERAEKEKLVQTVEEMIPLIASFDELLANMDKKSPSVQPNRFSAQPLDQGSNIDNFRGSISKTSGIRAPICHANIGESRIGKGGFGVPAPKENRSRSGSSMARPLSGIACKSGIMTSIERMGSNKGRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBD1</accession>
    <name>A0A0B1PBD1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative mitochondrial import receptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000167">
        <property type="protein sequence ID" value="KHJ36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBD1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBD1"/>
    <dbReference type="HOGENOM" id="CLU_032751_0_0_1"/>
    <dbReference type="OMA" id="GYMVHVG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="9">
        <location>
            <begin position="212"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="423" mass="47496" checksum="AA67E4C4A6B56FBB" modified="2015-03-04" version="1">MFELHVWGPAFGLPSIDPHCLAAIAYLQQAVPAGKWVVTASSNPTISPTYELPALRDGDIWIGGFRNIFHYLAQHSSGKWILDVGLSEQEGADCIAFSSFLDSTARLLLDLSLYVSIENYSKVTRPAYSNLQPFPLPYLMPDAIRSTARSRTQNLGLASFNIDREKDSINNSSKSISSIIPENLRRSKHTVSSLVTASPECVAQIRLNALAIDCLEPIENLRAKKRYLVSDVQITSLDCLALGYLSLMLIPELPQSWLAKTMRQKFPRLSAWTQELRTEIFGGAVGCQDVFSDRKKGDWGDRLPWQKSETENIWSRGQVFFLTMFDDLKGFGRLRRKDKMRSYTAKKSDNRNVWNTSSKIFTTLSAVFLTGATAGIGMILLSLFKTDHRKIKNEKFDNNKLNSFGDAGKILGAYSQEDEFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF6</accession>
    <name>A0A0B1PBF6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF6"/>
    <dbReference type="HOGENOM" id="CLU_012103_0_1_1"/>
    <dbReference type="OMA" id="ANSEMVC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="679" mass="74407" checksum="AB986C7C49FFDE3B" modified="2015-03-04" version="1">MAAMRAAILAAKDSAPIFGPDHPNPNKQLPSLTDEVRVRRLPSSNYRFPLQPRDKNAKMRAPLKAPTITKTATNSKMGPYDKQHQNSEQLTASTLSRSSKAFNRAPLTPRIASSVSLTGASPFTRRALSPAISVKSRDDTRSTPVSTYLNNVTPRSESRKSRVNSANSMPLSIYNDGSNPARDNIFTPSQSSDLGSDLENMGSDREYIRKPSVSFSGSFDNENPKKYIDTEKDSKFFFANEVKLAISSARTQSPKKNSPTFLYANQGSRNISHSKYPSVSSVGSMANEDRTYPIFYHANGTPDLSYSSATQSIPSRPSSAQSSTSRATTSKALGKQPTLMSVPITQPRSNSPSKLNQYVSSPRHLLHEQNLRSSSSLKVELANESSGTQDTNSLAIVSPAANFQGAPHLDETRDFTTSFSVNNDTVKPSDTISSLSTPANINASQSPIKAGNSLQQLNELAANARRERKVLDLEITNSSLAAINRTLEREMRKQTAELRRYRRLSRSGRLSIVKSPTNLMLSNGVDNQAPTLEPSADEDEDSEEYSTEQEEEISEDDSLDGSSLSPGIVSKSDLWHRKRDEKRLQLDLAKHQKLLASSQEVNQSIKRCLGLTEELIGEGLKALKYKVAATDVELGGRILTPDEKEDIDNEGMSEVGFQILKEARLSALNGKLGFNSNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC39</accession>
    <name>A0A0B1PC39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative enoyl-hydratase isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000984">
        <property type="protein sequence ID" value="KHJ34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC39"/>
    <dbReference type="STRING" id="52586.A0A0B1PC39"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="OMA" id="QYVAHVE"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="322" mass="35322" checksum="EB85E05F534F640B" modified="2015-03-04" version="1">MSSIHKQPPSDNINDEEESSAIGVKVGGEGGEKKYLYFIVTQPFPFVTHVEINRPEKLNSFHKAMWMELETIFDALSLASNVRVIVLSGAGDRAFCTGIDIKAALQGGILGKQKTPASTTSSQEDSRRKIDAARQAVSIRRHVVEFQKCVSSIERCEKPVICVLHGFTFGLGIDISACADIRLCSEDAKFAVKEVDIGLAADIGTLSRLPKLVGSFSWVKDVSLSARFFLANEALRVGFVSQILQNKVEALSEAFRMGQLLASKSPIAIQGTKELLNHARDHSIADSLQYTGVWNSAAIQTDDVYESLMSIDKKRSPKFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCC4</accession>
    <name>A0A0B1PCC4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000209">
        <property type="protein sequence ID" value="KHJ35908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCC4"/>
    <dbReference type="HOGENOM" id="CLU_088979_2_0_1"/>
    <dbReference type="OMA" id="WEMDSTH"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22316" checksum="00C2DDAED2E9AAE8" modified="2015-03-04" version="1">MAAPANITIKNLSGKWVMDKNKSTPPDPVLNTQGVGWAKRKAIGIATITLSVTQTVDDSGITHINIDQTATGGIPGTSEKRDLDWEVREHTDHVFGTLKGRTRWIALDAVKEPLSGEDYTDSEEDVKFLCEGWIEDASENGGPNGERHIDSFVRNESRGWTARQIWGFQLVDGARHYVRKVIVKKEKTVHQVTLIYDYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCG8</accession>
    <name>A0A0B1PCG8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000942">
        <property type="protein sequence ID" value="KHJ34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCG8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCG8"/>
    <dbReference type="HOGENOM" id="CLU_127753_0_0_1"/>
    <dbReference type="OMA" id="PQNVDAD"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="159" mass="16951" checksum="9ACB94EDC81AF6E5" modified="2015-03-04" version="1">MTLKRERTKNEKIASSSSSSAIDHDEESSLQGIAHIKSAEDRKTAAALSSIDVTSNDDCDGILGNSNSSPDNLDQEAVKKAMERLNKNSSLVGNASGPKEKNVQSSNGILSASKSIKVDPTDVTLLVEELELSKAKATSLLKSFEGDVQKALRSQIYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH9</accession>
    <name>A0A0B1PCH9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phd finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000042">
        <property type="protein sequence ID" value="KHJ36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCH9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCH9"/>
    <dbReference type="HOGENOM" id="CLU_015602_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="431"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="818" mass="93639" checksum="CF7D3EC29315E04E" modified="2015-03-04" version="1">MVSRKRGLQEFESNELPRESELLRQVRNMWEFASLSQWIHLFGRAVKIGEEVDTEYIESECLNPDSTALSDIGLAILKFVSSHRGLTHDIFDEYTRRQYVAKAPLQNPFGTDKEPTHFKELDIFTKIKVLQQLTQWTMVNPERIRERTIEQKDVEQIKWRTEQFGRDSEDRVYIVLADSRLYRRTEPKIQLSKPKKSSKKARAARRTSERIKASGLMEIKSTAVERENTDNKKKAQIDNGDQYETIWECMAINLEDYESFLSVIKKSRDPNEKMLFKRITNEVLPTLEKKLELKQRKQAQKESELLNLQKLACAKRSSRIASKMEQQKQLEELRSSERKRAAEIAMAQKEQKKWIRLEKERDSRIMTREQRLKEREARRILHEEELADLNLDKKRIENGEARLSERHLKAEIGRKKKMLEQLAEDDDWIFDCICGAYGQIDDGSHSIACDNCNTWQHSKCVGVSKTEADRTDFSFVCATCKRRADDSERAKSKLPITIKLSRHYLTKTPERLQLNIYHPTSPTLANSAEHDVPLHDIYLQELHKNQKKDDHTLLQPGELLNLKKSNYSPINDIDESSLNTDPISVISAHTNHKPDISESPSSKNPGQKADASPKKSYIKSYLDDPATSRTIDEKSINSSNGLQITQSHCTRNLTSQSPVKVDQTSLERDLVDFQLNSCDGKRQISSSKFSSLLTCVPTLSPCQLNNTDRKNATPSSTISTNLSGPQDIDLPEENKLSALYTGISISESHNAAVLPPAATGVSPIKNCHPRYVINNNQDEKCTSKLLPFTSLVPTTQILNHSSPVKPSESEKLDQLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM4</accession>
    <name>A0A0B1PCM4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000527">
        <property type="protein sequence ID" value="KHJ35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCM4"/>
    <dbReference type="HOGENOM" id="CLU_019274_0_0_1"/>
    <dbReference type="OMA" id="EYGMQKQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="618" mass="68786" checksum="E8CC0E00F3FE5FF2" modified="2015-03-04" version="1">MPCFKGIAVSVHAEGAPLPEYSVQKQSRVSRVNTYIPVPKLKIPIHGDKLEPSKFAISITLLTPGLPIPYSQPKSTPENPYPSPQIVADLPVADLPGLAVQKGGQSRTIGPYIPITKSENETIAAYIYFDGRKKEEVATLLRPGEETWVNSRWVQVPSSEGGGLAEREFLFREVGLERWLNGLDLDGQDAAAKIERRRQKYEMRRRRRKLESNGDNSKVSNSMDSSLRSLMRYGDDEKSPLEQISDGEFSWSSDSDDEGPPESAGQIKVAMFRVLASGEIKRGEYSPQFDVHDDEEEEKKSNNPEDGSLDHTTCFAKPKTLDPKSVSTQTVTGIDGPDKPFAVFTFFYRGERQLQKMGLISPKIAKNPLDSNKRRSTQLDFSTLKPLKLGGTVGFSTFREQIPSHKRIKSENNRNGIVKGLLEEDSDEDDDSSQLLEKVEDNEEKTKKSLLSPKDIESAVEIADGVERIKLKRQHSAEPLSSISRKLPGSNETRSVVTKLPDGSEVDIDLTQSLPTKSFALDFTEKSDVGSPLKKARAYVPELEVTDNQPVNQHGKELASIVSENMITSKTLQSAQITSSARIEEDLHMLEAAWEMSRTKIEFERPQLPANSYAIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCW8</accession>
    <name>A0A0B1PCW8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCW8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCW8"/>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OMA" id="EIDWCKQ"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018484">
        <property type="term" value="F:4-hydroxybenzaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047770">
        <property type="term" value="F:carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046185">
        <property type="term" value="P:aldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="59654" checksum="93FF082DF2F3B8A0" modified="2015-03-04" version="1">MEPLKLTPFETTKIDSIPSIVSRCKATFSSQTTKPIEFRLRQLRQLYWGLNDYSALLVEACKQDLGKPTFETFVTEIDWCKNDILFVTQNLKKWMKDEPAPDISLSNLLVKPKIRKEPLGTALVIGAYNFPIQLAIGPFIGLIAAGCTGVLKPSEVSPATASILKVIFDKYLDPSAFAIVNGAVTETTALLNEKWDKIFYTGNTQVGVIIAKKAAETLTPVCLELGGINPAIITKNADPYLAARRLLWGKLMNAGQVCISQNYILVEQEVLPIFVEHLKNTLNEFYPNGIRNSPDFGRIVNQRHFSRIKKMLEGTRGKVLLGGGVDEAENYIEITVVEVPDTDDPMIVNESFGPLIPILTFNGVDEAIRIANSIHSSPLGFYPFGNKVEVDKMLNEVTSGGASVNDAFFHGSISTLAFGGVGYSGQGSYRGKASFDTFTHRRSVTTTPNWMERLLNVRYPPYEGKLAKLRAMNSSKPNFDRNCKEIKNFKYWSGILFSLGSDSIKSALIKWAAIIIIFLSIKRFVYLSNEHMSWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY3</accession>
    <name>A0A0B1PCY3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000833">
        <property type="protein sequence ID" value="KHJ34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY3"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="30905" checksum="CE57D71A48BCE66B" modified="2015-03-04" version="1">MALPARDKKRGVSETLDPKRRIQKSTNNAGRAQPRAATLTRSVGKTNVAVEKIAATQVTQAVASPLTQNLDPPMEIDDEPDESEKEPEIDDFPPLSSNTTLKRNADIFSSSDQTQDIKEMELECPGAGSDFLALISDGVSRAVRGKKIFLKVDDPFDPQTTSARNNSWASRVAMKSIRSSNNPIRATPTRPTPPQGQSYEDKRVMIRLDKDHESRKTEPFLLRQQIQQLLPDPSFVCDAWQAPSGITILALAPAKAAAILQYKDVIARRFGNAIVERQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD19</accession>
    <name>A0A0B1PD19_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative na+-h+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000467">
        <property type="protein sequence ID" value="KHJ35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD19"/>
    <dbReference type="STRING" id="52586.A0A0B1PD19"/>
    <dbReference type="HOGENOM" id="CLU_1416140_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21473" checksum="08B8D3222297A811" modified="2015-03-04" version="1">MLIWLIWPITTFLVISSILVHGSSIAVFTLGKHINTLALTMSYTVGNEDGPGWVNRLPKITSTSRSQAKSISLGTDENELKIGDLPPGMLPPIGIPREFLRRQKEEESPVYNVYPVSRNRNERKKSMLWEDEVGPGGPISRSAIFPQRESEVHIESNDRVTSGKESPKNEKNLLKPVNTTSRSYSDRSVDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD72</accession>
    <name>A0A0B1PD72_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000789">
        <property type="protein sequence ID" value="KHJ34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD72"/>
    <dbReference type="HOGENOM" id="CLU_132238_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19159" checksum="A0F3FEF3F39E5CC4" modified="2015-03-04" version="1">MNSNNLTSVLYDPASPNAYDPFQSHVISTDRPPSSQNINLKFLDMDDPGPNTLFPQSPLPYGDEHEDLPPSPCAIQEALLSVNAAADQRALEAKSFFGPIAGILDQYCESNPNMSDKQQRAFKTFYDDLVKLASKHFDAYIRGTKVSPMSHKTSNEPPPPTDARPEKKTMQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD75</accession>
    <name>A0A0B1PD75_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000111">
        <property type="protein sequence ID" value="KHJ36203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD75"/>
    <dbReference type="STRING" id="52586.A0A0B1PD75"/>
    <dbReference type="HOGENOM" id="CLU_025144_2_0_1"/>
    <dbReference type="OMA" id="EKTHDLY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ36203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="60083" checksum="E6B98A0ED8A9E45B" modified="2015-03-04" version="1">MRSVLSPPSLLLLRFLKAQSEGVGFLCSINGKTEFSKDKQEIPKLYHAPSHFKNTKINHVSSNKVRLSSPNYLATIPAACKFSAHNHVPDPKRLFSGSPNLVTQRKISDGSRTWIFTKLWGKNKVFKNDNPIRIDNLYQSRTEENHDSSMFSLGRYISAKAATQPILRCTEIDEKGNVVLASGEFKKSELIAKYGLLPRDLRKIDSSLLPHILVRPSAILINLLHLRVLIKSNRVLVFDAYGTTDTYNQSAFIYDLENKLRHKQSSVSAGGLPYEFRALESVLISVITSLETEFEGVRAPVVRVLRDLEEDIDRDKLRLLLILSKKLGTFEQKAKLVRNAIDELLEADDDLAAMYLTEKSQNLVRGDDDHTEVEMLLESYHKLCDEIVQESGNLISNIRNTEEIVKAILDANRNSLMLLDLKFSIGTLGIGSGAFIAALFGMNLKNYLEDSNLGFLGVTGWTLIFSGIICTYGLSKLRGVQRLTMWGEGGRRGRSWRDEENRALLNRETKSLKRLERQRCTRDRRISGEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDE3</accession>
    <name>A0A0B1PDE3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000601">
        <property type="protein sequence ID" value="KHJ34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDE3"/>
    <dbReference type="HOGENOM" id="CLU_839906_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="331" mass="37528" checksum="1408317AC80437D1" modified="2015-03-04" version="1">MSAVDPKPTYTLKTEIYLVSLALSCRIAAVRKELLKMAGMPLNATERLDIMDKIHAKHLVDYIENDIEDGKEISLVELLIGRKEDQIREGLDNTGVQCIARAFVEWSSNCDTVYTGSRAAFIVMEDLVIAETYINMEMKDRFSKAADLAVGLTHASACALKMHPEATYAVITNMYREFVLRCGEVVHIREVAEDISFHTVSRRVRRAYAFAMSRRSFKAKDQVFQDGVSTKRFKERLSGAIRRNEDHISGIEYFFMGPVRAIKRGGELYIVDQDNIHKVYHTFHRRMMAVFSAHMSEISSACSYSAKITKDFFDTLIKAASDLAKKGRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDE4</accession>
    <name>A0A0B1PDE4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ring finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDE4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDE4"/>
    <dbReference type="HOGENOM" id="CLU_047453_0_0_1"/>
    <dbReference type="OMA" id="CLQSWRH"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="305" mass="35256" checksum="0A353A4BC4C6E693" modified="2015-03-04" version="1">MSIPNITEEKITHESQPFLLEKNHINTTDSSDQQKQFSTRTCRICLEEVYPSYEVSHKNFSSFFHPVPKPRWISEDPTSGRLLRPCLCRGSQKYVHELCLQKWRYANSHGLQKPNFWQCPTCKFQYRLQRMIWSRLIISPTVRIGITFIVIIATTFVFGFFADYIITLYTNPLITLSHISSESRAILNQEGDDSSWAIHFLKGFVSIGILGIMKTTLAMSPWQWVFKGFGVGRLRRRDQPAQDVLNGIPWIIIIFGVITFFHAVWKFVTAWTNFVLEKVGESVADIQDLNDEGKTEEPGFHLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDL9</accession>
    <name>A0A0B1PDL9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secretion pathway protein sls2 rcy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000074">
        <property type="protein sequence ID" value="KHJ36318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDL9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDL9"/>
    <dbReference type="HOGENOM" id="CLU_003875_0_0_1"/>
    <dbReference type="OMA" id="WYQVKRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="912" mass="104115" checksum="2841E6167C1BB9E1" modified="2015-03-04" version="1">MMFSSRNTQRITSDHLIISSLKATQLLNESKSLLPAELISNILELLSVPDLMRFARTSKRMLEMVYEDSRWVQRLQAIGVWNEEEARRRRAENFQIFGSEIKDNNYHNINWDLTYEGKLITTSNALHDIGRMEAKQLEMNSIKSTQNYSYDTHETRGGLTHFPKQMKSVISITTPDPEALLHILNQVKSIRGFARHEFAKIYAALAPYYYELTRSPDYSGQAIFNSFPNLEQQAQILAQILRFSRCDWAMGWKERDEKLSKIIHAFEIVQLREFEHGFITKDIHGKMREHARVLAILNGGQTAINYFVENCPMLKDQRIISSYPLDCPNQDSYEGISLPLFINFLEDASRILNEQSEVIDCVFPQAVDILHIVLGKFVEERFVPYVNSLLKNLYEKNPVLYIKAFPNVFEQSLKFGLSIRPSRNSSQNFSENVKKTIAKVFELQLNLYLQEELKYFKRNVESEGSKWEKKLNAQDATTESFLMANFNRVSDKKDFITSFKKVFKMPTRILPSVSKFGTKNPLNRENLYIPTSPSSISSQSPGSPHTNFPVLSPISPIEMTPNEELIARTAFIASQLEGIRSLVSIEVALKFTHAAKESIERTALFVCLSGQSGEKARKQCSLIYVSLIQILGEQHVQSGFDRAVNHLSKYNPREVIGHQQAVVPLVNFLELVNVGDLISQMIDVFYEQQLCANKLSDLNDSFDPAIQAKKNFEKMLDSCVAAGLNQGIDVLMGEVEYICATVQLPTDYNASSPSDCDLELRPSKAAELIVTLVESHTKILEGGTDKKVLDAFNQEVGLRLFSVLCRHLKRQRISINGAMKLISDMNHYFLYIKSLRNNELLEYFKALKALSQIFLIAPSHAKEIAEVVADKRRFSGLFSAEEVYEFVQRRADWYSVKKNVEKAMYGIGCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PER3</accession>
    <name>A0A0B1PER3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000414">
        <property type="protein sequence ID" value="KHJ35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PER3"/>
    <dbReference type="STRING" id="52586.A0A0B1PER3"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="36150" checksum="952A0218AEEAF36B" modified="2015-03-04" version="1">MNSKETIISLTSDNCSIKNNDHEEYQYLNLIREILQTGEHRPDRTGTGTYSIFAPRPLKFQLSASGKPILPLITTKRVFIRAIITELLWFISGSTSSIPLAEAGIKIWDGNGTREYLDSVGLSHRAVGDLGPIYGFQWRHFGAEYVDATTDYTGKGVDQLNDVITKLKTNPYDRRIILTAWNPSDLKLMALPPCHILAQFYVSFPRGDKNIGTLHCQLYQRSCDMGLGVPFNIASYALLTHMLAHVCGLHPGTLTHAMGDAHIYADHKEPLKIQLEREPRPFPEIEIKRQKYGSIDGWHVDDFIIKEYQPHNSIPMNMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEZ0</accession>
    <name>A0A0B1PEZ0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEZ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEZ0"/>
    <dbReference type="HOGENOM" id="CLU_047332_2_0_1"/>
    <dbReference type="OMA" id="RQKEMGG"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="188" mass="21485" checksum="A4F52CB1D00248B7" modified="2015-03-04" version="1">MVDKELTKEEEEAARAREAEEQAALPYKWNQTIGDLDISLEVPGNLRSRDLRVEIKKKTISIGVKGQEPILSGDLAHEIHVDESTWTLTDTPSGMKSLEIHLDKVNKMQWWEHVVLTAPKIDVTKITPENSKLSDLDGETRSMVEKMMFDQRQKELGKPTSDEQKKLDMLESFKKQHPEMDFSNAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF97</accession>
    <name>A0A0B1PF97_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF97"/>
    <dbReference type="STRING" id="52586.A0A0B1PF97"/>
    <dbReference type="HOGENOM" id="CLU_006057_0_0_1"/>
    <dbReference type="OMA" id="ERMNVTP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="978" mass="110327" checksum="4F961FD880617FD7" modified="2015-03-04" version="1">MATSFKIVNTDKGQNWNFNTTQCLVSAKDCIVSFVPGYLTKLMNQFVQITISIKDLRSDSNILPENIRREVIAQNMETITTAVPTRSFGLFTETGVEKEIQATGSSSKFTMEGARTVGNIFNYVTSKWALGCIVTAVILNRTNVYARTRWNLQLSWKVRFLLRITPIILLAMQCRKILQSLHCQTSPEFTLMRWGNASVQSDLIFNQSGNFLYKISSILLLGASDKKSCLDMNMIPPEYNSKINKLDSEIETIPIELKGSLPILWPLFKTFAFSQFVETISCAVLGRQIVTEYGMSLFELSLAFTEAEAIAMNKSDIGGLETSTTSATWINTAGNVNTRNLMDRPKIIKYINTSPEVLLIGFISAMNHLTSHFLALFDQQSNFRLLNTGIWGLAYTASILQGISSFSLDDRPDQSIFRFPTVCVISFIPHVLIIFGIVGCSIIYIVALLLTATSLPPMVEEIGHSDLNSNCPLIQKIWLAHKNMQANVSFSRIHVTLSMDFYTALLRTGISIMSMANEAVYLNESRGVNIKQRTWLEDERLQELETNGLNWLEPRDQLRDSSAELTDVFSNDISLVTAEDQPIDRLQQVPSGYLREMITHTSGSGNRQQGRLSSNVAGTTERSGRWYMAFELCLGFSRLLLGCYGAFHLWLIARLGIRAQPKWLLWMARPPKSFSKDLKSNNQVDFDSFDSLNSYEENSELKKQIDMDIEDEFRKIAIQNRQVWTDADEKKLDADLYRWWLDGGCWGEKDSSGNFAPTGQGEDDDTSSVVSTRTTEGDYWQSDSADEDNHLTPTQMTPLFSRESTPYYDTTLTVSNLAQLLNPKTPEMRAEAEALSIHLSNDHVVTRSRFHKLRQRSRAKFLTSTRVRPPNFTPSSPSGKLTLEEESQILEYLIVSRRGLTNNSNQNQSASWARNNIGIDEAGPLCVVCQTSPRCIIIWPCRCLSLCNDCRVTLAMNNFEKCVCCRRDVGSFSRIFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFI0</accession>
    <name>A0A0B1PFI0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000153">
        <property type="protein sequence ID" value="KHJ36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFI0"/>
    <dbReference type="HOGENOM" id="CLU_037541_0_0_1"/>
    <dbReference type="OMA" id="RFPQDSY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="39762" checksum="581D0B112DA1B838" modified="2015-03-04" version="1">MPSRIESPLPVVPEPTTYRKSILGRPRTKTGFSLRSSHSRKSSTSASKVVLHESHEEKEAHRLQSKADPSMAIVEVEPSEVASNTKITIAPIRAIQHRDNYGNLITEPDRSNPTRNRWERPLDTIRSFEAAIDGSYLRKSQLRNDSIAMKRRSHYAGSSHSAYEENLRTRPRSYYSPSPTPSAQYNSYENNNHYLSRPRNSRSEFYNSHTIYSVPDVQETYEFANSASGSGSSLDPSYSTGQSSENSSIDRVVPIPQKESNDCISSNGGYEAPFQRYTISSQSQDVHKPTNESSQVIPDLSVKSVPRTPIKLGNNTVSRILSTTTKSKSEKRGSWLRRRLSRISRDHDQLSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFJ9</accession>
    <name>A0A0B1PFJ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cullin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000432">
        <property type="protein sequence ID" value="KHJ35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFJ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFJ9"/>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="449"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="842" mass="97102" checksum="4AB44CB5CEDD3CB1" modified="2015-03-04" version="1">MISGRGRGKIRPPRRSLTTHDDSKDLETQWDILKSSLMEIHTKNASTLSFEQIYRASYKMVLKKQGDQLYDRVIKFEQDWLCSVTMPQIRTLISNNLVSFAFDSFTGVTANERRLTGEQFLKGIKASWEDHIMITNMTTDVLMYMDRVYCADNRKASIFTTFMGLFRDHILRSKPAGYDVILFDILNAIILDQIDMERDGDVINKSLIRSCVYMLEGLYETDFENADEKLYLTVFEVEYLKNSQKFYQKECTKLLRSSDASTWLRQTKRRLEEEESRCQTTISILTAPKISKIIEAEMISAHISEFLAMEISGVKAMIENDRLEDLTLLYQLLARVDSLKEPLMIALQSRVVELGSDINNNFLVADNSNNTIALQDQGEKTIERIEKQNSLSKSGTAARQLTAAIRWVDEVLRLKDKFNMLWEQCLHKDLVLQTAITKSFSQFINLFPRCSEYLSLFIDDNLKRGIKGKTETEIDDLLDKAVTLLQYIHDKDMFERYYKKHLARRLLYKKSESGDVEKQMISKMKQEIGNSFTTKIEGMFRDMTISDELTSQYRRHTQDSGSSNKSKIDLGINILTTNYWPIESMGGGSALRADRIRVPCIWPSEIVFLQESFKRFYLKDRNGRQITWLGFLGSADIRCFFPKVAGKEGTLGRDRRYEIIVPTYGMIVLLLFNNVADCESLSFEEIQENTSIPSSDLSRILFTLSVPPKCKVLNKIPANKELPKPGDQFSFNATFTSKVMKIKAPVVVGGGVNSVEADDERKETETRNDEHRGNVIDTVIVRIMKTRKQLAHQELFSETISQLSSRFKPDINLMKRRIESLIEREYIERVENTTVPTYQYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFX2</accession>
    <name>A0A0B1PFX2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000377">
        <property type="protein sequence ID" value="KHJ35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFX2"/>
    <dbReference type="STRING" id="52586.A0A0B1PFX2"/>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="OMA" id="KVYYMFG"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="647" mass="72324" checksum="D64B8351FB0EBD63" modified="2015-03-04" version="1">MLPKDLLPSTALIAFLISVPYYSNAFYLPGVAPTTYGLDDKVPLHVNRLSPLTSGVDGTLHSVVSFDYYHPAFHFCRPSPQPEYVPESLGSILFGDRIMTSPFELKMARNETCKTLCSGKKFDPISAQFVNRRITQGFAMNWLVDGLPAGQLIEDEMTNTKFYSQGFALGSADQKNLYFNNHYDILIDYHETSSGFYRVVGVIVQPDSRAIKKEDESVKNTQNCGLGAPKITLDEKGETEVDFTYSVYWLKSSTAWATRWDKYLHVFDPKIHWFSLINSTIIVVFLVVTVMSVLLRALKKDIARYNRLDSFNLDDLSGTSAIDDGIQEDSGWKLVHGDVFRSPSSALILSVFLGNGAQLFIMTGLTIIFALLGFLSPSNRGSLGTIMVLLYTVLGLVGGYVSSRVYNFFGGENWKLNIVLTPTLVPGIVFSTFFLLNLFLWAKESSGAVPFTTMLVLVGIWFLISVPLSLTGSWFGFRQPSISPPVHTNQIPRQIPPCSVYLKPIPSMLLVGILPFGAIFVELYFIMSSIWLSKAYYMFGFLFLCYSLMVITCAAVTILMVYFLLCSENYHWHWRSFTTAGASAGYVFANAIIYWLTKLQPVGLTSSVLYIGYSALISFLFFILTGSIGFFASWAFVQRIYGSIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG02</accession>
    <name>A0A0B1PG02_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative c2h2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000106">
        <property type="protein sequence ID" value="KHJ36220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG02"/>
    <dbReference type="STRING" id="52586.A0A0B1PG02"/>
    <dbReference type="HOGENOM" id="CLU_055660_1_0_1"/>
    <dbReference type="OMA" id="CMTPQKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="28939" checksum="F4EC348A08F77D25" modified="2015-03-04" version="1">MAKRSRKEFEDSSEDSIQLSFDNLNTSISEPKAAINIGQSPCKLIELDPNNLDLNTFAAAPVMYCSLLPHRHTLKFDSFEEYNVHYAKEHTNRCLVCFKNFPTDHLLSLHIEENHNSLFVIKKERGNKMYACFVEDCDRLCSSPQKRKMHMIDKHFFPKDYDFYVVNHGIGNRSSMLKSWNRRIGGSSDVSSAPDDKHKTQLRVEKTLTSATAMSNSQKSLEDQNMNDLASAMSSLRFIPPSVRFKHVRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG32</accession>
    <name>A0A0B1PG32_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4403</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000351">
        <property type="protein sequence ID" value="KHJ35559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG32"/>
    <dbReference type="STRING" id="52586.A0A0B1PG32"/>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OMA" id="INYICQL"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="563"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="824" mass="92513" checksum="72BE242EB2BD368E" modified="2015-03-04" version="1">MKCWAQIVTTPTADTPGTALLLHFDSKRYLIGNLAEGIQRASIQRKFGLIKVSDIFLTGTLGWSNSGGLLGLILTIADMRSASLEEKKASKLEKLPPKNRAEPEKNQSLTLHGGSNLTHLLATSRRFIFRKGMPITTNEFTVKRESKRNDWAPSWRDENIKVWTMVIEPEESFATLRKRSHDEISDSNSIENSQISYQEDDNESQFARMSVVSSMFDSSWRYDTLVKRKLSEVKLPATIFRRGDDGKIQIYKGPTISEDSSVGDLEVLVRNPWPGALVERLPSTTPSKSSICYIIKNYAQRGKFNPQRAKELGVTPGPDFSRLTKGESVIATTGDVVTPEMVLGRGKDGGGFAVLEVPNESYIEPLFARKEWSSDTVMLGVGAIFWILGPGVINDPRLKMFMKEHDKLKHIVSSVDCCPNYLALESAATAAIRLNILDSKHFPIPDFNNKVQNLINEDSDIFQEAKSGMILQLEPTLEIQDKSIVPLLNTNRLISEFPKEVKELAEAACREIENPEYLLTLANNQSDILCKNAEVVTLGTGSSLPSKYRNVSATIVLVPGFGNYLFDCGENTLGQLRRVFGAQVLDVLRNLKVIWISHLHADHHLGTVSVIKAWHEEIQRLDVNKENKLIIASDLGMINWLNEYAEVEDYGYNQVELIALNEQRDYEYHLCEKQSSRAGLSSIQACRVEHCAGALAVVFKFPNGFKIAYSGDCRPSSRFVKIGQGATLLIHEATFDDELRDDAIAKKHSTTSEALEIGKRMNARRILLTHFSQRYQKIPIMNDNKGKDQVAIVAFDYMKIKIEDFAKMEAFKPALIKLYEEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG63</accession>
    <name>A0A0B1PG63_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000340">
        <property type="protein sequence ID" value="KHJ35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG63"/>
    <dbReference type="HOGENOM" id="CLU_2414935_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="92" mass="10075" checksum="81A24F4CEECEC100" modified="2015-03-04" version="1">MIQPVQAAVIFLLGTKGIGWLDNWRDTKALECDNKFASLEYMISSLRAVEANTTPSKLTIYAASIAPNKAEGCNRSNNQAEAIKLNDGKFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH32</accession>
    <name>A0A0B1PH32_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000249">
        <property type="protein sequence ID" value="KHJ35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH32"/>
    <dbReference type="STRING" id="52586.A0A0B1PH32"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="112"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="576" mass="64620" checksum="710419C5774D562D" modified="2015-03-04" version="1">MSGSQIKQAAIHKAKQVAYVSNGSASKKRKKDVLKPIITAESNHEAEAPTGQAATGARNINNAKNSTVNRTPSNSSREETADTTADEEDCEDYCKGGYHPVTIGEKFKEGRYTVIRKLGWGHFSTVWLSRDNVTGKHVALKVVRSAAHYTETAMDEIKLLTRIASAKPDHPGRKHVVSLLDSFQHKGPNGIHICMVFEVLGENLLGLIKRWNHRGIPLPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEHIVKTYVKDNIKEKEDNPNGRRRRRTLITGSQPLPSPLDSSFNQPETSSRARKSSGAHTSLNKILHEDISKEISAAENQDEENHKQREKTADILSRQVGDISLDKRTSERKESETRVFDVISVKIADLGNACWTNHHFTDDIQTRQYRSPEVILGAKWGASTDVWSMAAMIFELITGDYLFDPQSGSKYGKDDDHIAQIIELLGPFPRSLCLSGKWSQEIFTRKGDLRHIHRLRHWALPDVLKEKYHFQDEAGRRVADFLLPMLELVPEKRANAGGMASHEWLEDTIGMKGIEIKGLEIGSRGEGIDGWGCEVRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUL4</accession>
    <name>A0A0B1NUL4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005376">
        <property type="protein sequence ID" value="KHJ30062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUL4"/>
    <dbReference type="STRING" id="52586.A0A0B1NUL4"/>
    <dbReference type="HOGENOM" id="CLU_096917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28802" checksum="8B25FAFC5FC72D8B" modified="2015-03-04" version="1">MIICVKMIFPSWKIYSRDISQAYTQSGTKLNRKFFIKAPKEISIGDENILQVLLPLYGVPEAGTHWFARYHKWHLDALKLSTSSYDPCLMFGPNSIVGLQTDDTLYASNQEYANFEDTELKKAKFKAKDIEILSENFPMTFNGVNIKIVKDSICMTQQRQCRKIELINPKNKDFKSQYVCQRARGAYIASMIQPEASFSLSYAAQTTDPSTDDVELLNKCLKWQFDNQSRGLRFIKLSPKGLKTFVFVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV00</accession>
    <name>A0A0B1NV00_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004832">
        <property type="protein sequence ID" value="KHJ30187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV00"/>
    <dbReference type="STRING" id="52586.A0A0B1NV00"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="ISHICWV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="38037" checksum="150C121467E57BB6" modified="2015-03-04" version="1">MMIFAFSAYKPMDDTLFGANETFCIKEQTQLAKAGFIAKEREMLTISTPIKFNGGKINLEEDNSITLTQAQHCENLSIIISNPIDTISPRSKIRKSLGPKEQYVAQRVRGAYVGNTCQPEASFDLSSSAQIIDPTEKDIKQLNQRINWQIKNSYRGIKFVKLDEKSLKVIVFADSSFANNKDLSSQIGFIVILADKVSRANIIHWSSTKCKRITRSVLAAELYAMVHGFDSGATIKSTLEKILGIRITFIIFTDSKSLYECLVKLGTIREKRLMIDLMCLCQSYERREISHICWVKGGCNPADAVTKSKCSNALRDLINTNTIKIHNNEWVEREETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVQ8</accession>
    <name>A0A0B1NVQ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004245">
        <property type="protein sequence ID" value="KHJ30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVQ8"/>
    <dbReference type="STRING" id="52586.A0A0B1NVQ8"/>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="13855" checksum="ABB5F7B59BCC2DCE" modified="2015-03-04" version="1">MAAPASTYKDREFLAIIGDEDSVTGLLLAGIGHVTAPPDSQKNFLVVDSKTDNAAIEEAFDQFTSHRKDIGIVLINQHIAERIRHRVDSYTAAFPALLEIPSKDYPYDPEKDSVLRRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWM1</accession>
    <name>A0A0B1NWM1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative capsule-associated protein cap1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004439">
        <property type="protein sequence ID" value="KHJ30343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWM1"/>
    <dbReference type="HOGENOM" id="CLU_005027_4_2_1"/>
    <dbReference type="OMA" id="LFAWRHF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="332"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="647" mass="75695" checksum="E031A2665237336A" modified="2015-03-04" version="1">MLKTYDYSSRWLFTCFGVIIILITLINLHSLSVIDVRSRLRNLYIPISGRGKWTELGLRPDPYPYDDFDKYSKVNDHHPIAKSMQEADLSWLKYNENRSTTFFETITKYRKTYGRHPPPGFPDWYRFARDRNVHHLDDFKQIMDDLRPFWAIKPSTIRLQAAHLHQNPDHGISGLHIRQNKVWKLTNVDWRMEIFSKMVKPFVKFLPDMDVAMNRLDQPRMVVPWDDMQSLLAKENESKRLHEKVEDKWTKNLVGLFNGNDEEHPSAVDLGFFPAHGQQYMNIARESCPPESPARNSSFHPKDIEKLYKDAESGLVTNFNLSSDLCTVGPVLENKHGFLFAPSTIWATRKLLPIFGESKTSVNSDILFPANMYYSNDKRYAYDPTYDYDWDDKKDCLLWRGVTSGGTNTVDNWQNMHRQRLVAVANATLVADKKSRILKYNMNLNGAYYRPWSHFNPSNWLINHTDVGFTEPIACVPNCEFYKDLLSFKEQMTLSQQFKYKYLVDVDGHSFSGRWHAFLRSKSLPIKSTIFREWHDSRLFAWKHFVPLDNLYDDLYSILTYFIGLGSPISAKRGVPYVQRHNFEGRKIGLQGREWAAKVLRQEDIEVYLFRLLLEYGRLIDDNRDLIGYTGDGSELAEFDSKYARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXE3</accession>
    <name>A0A0B1NXE3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003803">
        <property type="protein sequence ID" value="KHJ30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXE3"/>
    <dbReference type="STRING" id="52586.A0A0B1NXE3"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_0_1"/>
    <dbReference type="OMA" id="KMHEDSF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31388" checksum="1D79C693390352DA" modified="2015-03-04" version="1">MPEVRKPRRQHSLAHYAKTRARSRLLEKGLAIDEIDFEAIEAEIIKGIEEIPVIEMVDTKVDKIITQGLNDSQWARPIQDKDSENNSQISRNLQSKTAARGAGQVKDLSKSIQQPNRSLPALSTRPNTEDTSPQTAYQSTEIDNARFEEVVGKMSVPQELQEMIEAEICRAAQAKANIQICTTAINAVEDSLSPMLTGGNKSFVNSLRVFLRASIAQFLQVGPGAAPPKLPMVPPRTLLTVAKMHEDSFPSLGPKTCAISPAQQEPSEQQQDGSWVTVLKGGNSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXQ9</accession>
    <name>A0A0B1NXQ9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g2673</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="JNVN01003152">
        <property type="protein sequence ID" value="KHJ31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXQ9"/>
    <dbReference type="STRING" id="52586.A0A0B1NXQ9"/>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="105"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ31177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="55408" checksum="EE217CE0D64C95D0" modified="2015-03-04" version="1">MLLKGPEIAKHNSEKSCWVIIHKKAYDVTEFLSNHPGGSEIILKFAGKDATSEFEPIHPSDTLQKYLDQSKHLGDVDMNSVKIEKQDLNEIKEEEKRQERIKVMPSLEECYNLQDFEAVASGVLKRNAWAYYSSGADDETTMRENNAAFRRIWFRPRVLIDVEKVDCSSTMLGHKVDMPYYITATALGKLGNPEGEVILTRAAKKHNVIQMIPTLGSCSLDEILDAADSSQVQWLQLYVNKDRALTKRIVQHAEKRGCKGLFITVDAPQLGRREKDMRSKFTNARPKITIDTRIDTSQGASRAISSFIDPSLNWKDIPWFREITRMPIVLKGVQCIEDVLLAIDAGVQGVVLSNHGGRQLDFARSAIEILAEVMPALRELRLESKIEVYIDGGVRRATDIIKALCLGAKGVGIGRPFLYAMSAYGQSGVDRAMDILKDEMEVNLRLLGCKEINGLNPTFIDSRALGSHSSMMQISSNGLLSCDSIEFSRGKVSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXT0</accession>
    <name>A0A0B1NXT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003651">
        <property type="protein sequence ID" value="KHJ30768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXT0"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="24573" checksum="3AC7ECBCB62EE50A" modified="2015-03-04" version="1">MIDSMDISQESQALSTDSSNKPPPIPPIPPIPISPSPIASPPSPLNLQSLTKNTDGRQILKPVAPSKRPGTERTTLNNSNKINIGNAFLPKELADIVAIQQRRERAWHARLIIFTTAISSLESTLANFKDEIEVEEVAAFKAYLQLAIANFAAVDNSPIPHKIPSHSRPSKGSSHGLGKDEITAKKVAVAIPRSITSIESSLGKTQETVSLPKIPEIVESTWATVAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXY5</accession>
    <name>A0A0B1NXY5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003609">
        <property type="protein sequence ID" value="KHJ30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXY5"/>
    <dbReference type="HOGENOM" id="CLU_664291_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="414" mass="46375" checksum="25DD6DCC5790BCB4" modified="2015-03-04" version="1">MENHMQYIPPKQSRESSFRHTREKESISSKISSVDFDFQSDINNEESPFSSCRSSLGAEFSENQNAYLKSRGPNSNESIRIRCENHPDPIQFQFSKLHSVSVGKVIDETIAAIEATNRELLSRAQAAEKSTRILQEQNSDLQRTLNKFTRFNPDPCSPPLANINHRSRPSLNFPRSNPIVPQHRNSLGHSVGIATGSKDSFDFLDAELTASLRSRDRSSHITQSMQSFHFSPKTPSSSLNSPLPLLPTSPPSVQHNNISKSHHSRKNSLDFGNTDLSHSNNVQSSSPFSSSDFQPLSSHPASNISSPLPGTVRYHPVTIEGAKFNESNRPKLVSLEEARRRAKYTSTTPMKSTIHITPEDNNHFIEGNLVSLSDEVLPQKMGEKEIKSEKKKNRLQDLFTGRRNGSRKFSLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXY9</accession>
    <name>A0A0B1NXY9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003598">
        <property type="protein sequence ID" value="KHJ30803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXY9"/>
    <dbReference type="STRING" id="52586.A0A0B1NXY9"/>
    <dbReference type="HOGENOM" id="CLU_491075_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="64538" checksum="8CADB90892A30580" modified="2015-03-04" version="1">MQTSKPRKIGNGIITKNKPEMSPCSFRKSANGGLCDELWMRIFELTDARFLSTRARLICRRFKNIIDNCNSLFLNQRIEIYGTNLPGPPKGMSERQYNNLLGGKGCEECSDRSCTATKWAWYKRWCVSCWEKKIAKEHDIVRDYENYVPEIIMLQLLECLPYCMYDAYMKPQDVRRGRSTNPHIGPKVYKYYQTRDVADIIESYKTLLPAPYDEDPTLTLDEQISAMIKYQDLTEKLFEKRKTFLTQKNRERDELMERVYKIENAIRIRRQEISRPNKIARQGRREFHTKMAMQELPHIPIDFIQKGKSFKASCRIYRNAGTERTWKALKPKIENEWKQELEKRATFAVESNTNVDILESYLSKNSSTQLKTNSLPYQNMEKPDLMKKSFIWQESSLSQRNNEPQIMPRPLINKYHPSRTSCDISLEHRLSFVSNECLNAPEGSKLNIARSTFKNSDVTMVMPQNGQAFQAEPNSFGKKNSHKSCESNVLDDSSYRSNTRPSILARTLYETSQIKDIWNSPHAVSLESSVIPNSTERTVIPISSLLTNELLPVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY93</accession>
    <name>A0A0B1NY93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003003">
        <property type="protein sequence ID" value="KHJ31312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY93"/>
    <dbReference type="STRING" id="52586.A0A0B1NY93"/>
    <dbReference type="HOGENOM" id="CLU_582917_0_0_1"/>
    <dbReference type="OMA" id="RFCEKDS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="469" mass="52211" checksum="06996A11E3267D34" modified="2015-03-04" version="1">MNNSDHNFPSSPNPQVNTSTQLRAEASDPMPSKSGRLHPSLLSIANAMQQLETERKERMGLAQEFLEIIDAWAKGKTGTKAEAIIVPLIQKIAPTVTAFATGAVEGALLVPTSTHKAKNFQSLSEKPIHNNIQLDENKQNQRNYNTSWATVARKSAKLPQPPSSAIPLPKKPDGNKKETESNHPKEDKRLFLRLRPDHAWRKLSPIAIKKMITEKAGVAATAITALYSVRSGYAIECVSDALRDTILTAGKSLGDTDAIIEAASDWTSLLVPNVPLRIRTLDSNVIVTSEMVANECLAVCGMLPIQLRPMKSSTGQFYTSWLIHFKKRPVDIHFRLFDESGPAMAFKRRRPIEQCQKCWGFHSTRFCEKDSHCGKCKGSHETEKCEAKTPKCSNCNGPHMSTDVKCMARPRRQGEHFVPRTPAELKIIKERGNRDFQAALAEARKADELDKEERTPEGVTILEENMQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYA9</accession>
    <name>A0A0B1NYA9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005593">
        <property type="protein sequence ID" value="KHJ30025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYA9"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="151" mass="16586" checksum="E48B53C322628088" modified="2015-03-04" version="1">MSKIRPRVSIVERASAAPTDNRLFLRLPQEHEWRKLSPAGIREVIVKKLSISPVWVGKIKPVNSGFALSPCSTEPREKILNAGNGLFLTGAKLEAATNWVSVLIPTVPAFLHKEQGVVEVSNSMLADEVERTASNMDGILSESSTRHFQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYM8</accession>
    <name>A0A0B1NYM8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glycolipid 2-alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005002">
        <property type="protein sequence ID" value="KHJ30140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYM8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYM8"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_1_1"/>
    <dbReference type="OMA" id="YCDIHYD"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="48745" checksum="83C15EB4FBE92450" modified="2015-03-04" version="1">MLSWMSRYLRYILFALTSLAILFFISSSSTRLPSEILEKGKQWTGIPLRPVTQAPDDTSSLKASPLVETTLHEPTNIPLAEINSTINAAKMNATFVTLARNSDVWDIARSIRQVEDRFNRKFHYDWVFLNDQPFDTTFKKVTTSLVSGQTFYGQIPKEQWSFPAHIDQNKARKVREDMAQRKIIYGDSISYRHMCRFESGFFFRQPLMNKYEWYWRVEPSIELFCDIDYDVFRFMSYHKKKYSFVLSLYEYVETIPTLWESVKKFMKAHPEHISEGNSMGFLSDDGGNSYNHCHMWSNFEIGNLDWLRSKAYLDYFESLDQDGGFFYERWGDAPIHSIAAALLLKKEEIHFFEDIAYYHVPFTHCPTSEKMRLDSKCHCNPQDNFDWKAYSCTSRFFEINNMKKPEGYQNQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYN4</accession>
    <name>A0A0B1NYN4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004992">
        <property type="protein sequence ID" value="KHJ30145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYN4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYN4"/>
    <dbReference type="HOGENOM" id="CLU_001908_3_0_1"/>
    <dbReference type="OMA" id="SGNNWMA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="977" mass="110090" checksum="FF2B3B1430086879" modified="2015-03-04" version="1">MKCMFEKSLYDLIRGLRNHKGNEKEYIQNCLKECRVEIKGQDNDLKTTALLKLIYLEMFGHDMSWAAFHVLEVMSSTNYLQKRVGYLGAMQSFRTDTDVLMLATNLLKKDLTSTSIPTISLPITTLPHIITSSLALSTLQDLLPRMSHSDPVLRKKAIVTLYRLALVYPEALRPAWPKIKSRLVDEEEDASVTAAIVNVVCELGWRRPQDFLPLAPRLFELLVNGGNNWMAIKLIKLFATLTPLEPRLIKKLLPPLTSIIRTTPAMSLQYECINGIIQGGILNSCEESISSEEIATLCVSKLRDMIMVDGDANLKFVALLAFNRIVLTYPSLVEQQEDVIMECIDSPDISIRSRALDLVVGMVNVENLISIIDRLMTQLKDSRSGNNEDFNSQPNPIEMTPDLDETSESMITSKIISSESLIVPDDYKLNVICRILDMCSSNNYSNLMDFDWYINTLIQLIYLIPSSEPLSTQSSDMNLNNFSVFKTSERIGEELRNVAVKVRAVREQVTRAAEVLLISTSNNELPPHIVSSGALGPIGWVVGEFASDLAVPESTLSAIIYLLKESVKPEILIIYLHTLPKIFSFIVGDNQREWTRERKTMISLLLAKIIYAFEPFTIHPDLEVQERAVEFSELLKLTLEALSSQEASTGNTLQEAPLLLTQALPSLFSGFELNSIAPSAQKNVPLPIELDLEQVINVDLALHLKDADSPLYDEPAKEAFDIYYHTPFSSTFGVSKAKSSCFISKESNLSYQEGNKEVFLDTEMSKRRHAERMEKHRDDPFYIFNADEASMISSPPPNLEKTSYRSQLDLHEIPIIQLDPGRSTYPLSKTPEKILCTPETRKKLEVATDETLAISNILSSHLKNPQGSSEVAQKPKQNKNTSLLQVDSSHIVNFSLDEDFMEGQNDYYQEDDTQIIKAMKEVEMKRLELLRAKERILAPHGAEGVTVVKKKKKKKKKKIKPTKFESDAIDIESTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ99</accession>
    <name>A0A0B1NZ99_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ccaat-binding factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005629">
        <property type="protein sequence ID" value="KHJ30016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ99"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ99"/>
    <dbReference type="HOGENOM" id="CLU_045277_1_0_1"/>
    <dbReference type="OMA" id="THMSPAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="378" mass="43056" checksum="181EB2BF4AB2F261" modified="2015-03-04" version="1">MEQLSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQQVPDQRRNQPAYDMNLGGHFGASAALSNQGSVLVPEFYSGTWVNVYQGLHGTFKDILTTYWQHIINHLENDTHDYKLHQLPLARIKKVMKADPEVRMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQRSDIASALSKSDMFDFLIDIVPREESSLDRHKRVVPPTMAPTRQQIQTLRPPPQFMTHMSPAGQGAFVQRPGIYTSDLQSGSGPTGYGGPTGQMYGEMDGMYGYASIQPQQPIYQVQQSQQQLHTQSSSQQQQSQSSRQQQQQQQSLSQSQTPQQSRQAPMGHDLSAVRNDSNVAQHSYIVRDDADADGERDYETSQATESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM6</accession>
    <name>A0A0B1NZM6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002576">
        <property type="protein sequence ID" value="KHJ31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZM6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZM6"/>
    <dbReference type="HOGENOM" id="CLU_1741922_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="150" mass="16535" checksum="14659E7A3783EA66" modified="2015-03-04" version="1">MTLKAVNDTAGPNGLLSHELVPPSTSFPRAFLSGLRRINSLSDSGSLVGLTSMKALRRVQAERQINDAINTRNGPSIHEIPSLPLQSEVCVWREKNGWQGPFKVMATDGHIVTVDMLNVPATFRSTVLKPYYRDINTMIESPSSKNDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN5</accession>
    <name>A0A0B1NZN5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002571">
        <property type="protein sequence ID" value="KHJ31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZN5"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="540" mass="58968" checksum="6D918C70229DC1EB" modified="2015-03-04" version="1">MQAPVLVMNTQSGNRQTGRKAQVSNITAAKLVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVSHPAAKSMIELSRTQDEEVGDGTTTVIILAGEILALALPQLERNIHPVVIISAFKNALKDALHIIEEISLPVDTSDDKAMHQLIASSIGTKYVNRWSELMCNLALTAVRTVTHEVDVGIKEVDIKRYARVEKIPGGQIEDSKVLDGVMLNKDITHPKMRRRIENPRIVLLDCTLEYKKGESQTNVEISKEEDWNKILQIEEEQVKIMCDAILAVKPDLVITEKGVSDLAQHYFVKAKVTALRRVRKTDNNRIARATGATIVNRVEDLQESDVGTKCGLFEIEKIGDEYFTFLTKCQSPKACTILLRGPSKDVLNEIERNLADAMGVARNVLFHPRLSPGGGATEMAIAVRLGQLAKGIEGVQQWPYKAIAEAMEVIPRTLIQNAGASPIRVLTALRAKHAEGESTWGINGDNGGLVDMKSYGVWEPEAVKSQSIKTAIESACLLLRVDDICSAKAARQSGGGGATQGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZQ2</accession>
    <name>A0A0B1NZQ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative m serotype protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005371">
        <property type="protein sequence ID" value="KHJ30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZQ2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZQ2"/>
    <dbReference type="HOGENOM" id="CLU_015321_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="506" mass="55984" checksum="00637E8D96552974" modified="2015-03-04" version="1">MSAATKKPLVGGSENRAILRDTSIASPNRNPIRSTPSSTSGTGSVVTRSRSVRSPAPATNRASISRFNNINVKASQATANPEPEDEPRNVNAELLEDLSERLRKSEELSNEHQKQIQALQSRLEETTKEKVSLEEKVHENEERIEILENEKREAIRSKRELEAIYEAEKASVIKEREEASNREEELQMIIQRLKESQNTQLNGDEEFRTNRRSNNTSPNLENGQFTTSGLNRSDSLNNSKLLLQKDRLIESLRMELAECQTKIVESENTGENRLQDIVLNLLDKDLPSPPKETNSTTALKRAKTVAMGTTRRPRPQSFMPSSSHSLVTDQGTAPSIPFNLHRSNNHRNIRPHSEQFTGSASIAVSQMLRYGPISPPIQGGLSPRHSSAAAVPPTPVGHQNNTQSNPSIRQSSISSNCPGTISESSCTSSEGSDLNTPPTNSPPRIEKATTFAGNKPRPLRLLQETGPSEAARRSEEAAAKLAKRSSWMGWAFGKKEDTHVENMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P049</accession>
    <name>A0A0B1P049_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative vacuolar protein sorting-associated protein 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002736">
        <property type="protein sequence ID" value="KHJ31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P049"/>
    <dbReference type="STRING" id="52586.A0A0B1P049"/>
    <dbReference type="HOGENOM" id="CLU_024079_0_1_1"/>
    <dbReference type="OMA" id="LFGQAKF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080403" evidence="1">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="37809" checksum="A587F348A954E5E0" modified="2015-03-04" version="1">MASLLVYFFFVLWLDTTFAFSIKRISQRDGQLPQFVKDFAPLVFLDKNEKYFPSDIGKHLENTTPFIDKTAIDPAPSIAVENLDSLNQYINEVNNVYLTLKEPIENDPAFLQGTQPNENGKTVDATSCVVIVTDHGDGIIDAFYMYFYSFNQGNVVLSQELGDHVGDWEHTMVRFKNGAPDALWLSQHSSGQAFSYDIMKKKGDRPIVYSARGTHANYAIEGGHDHTIPGINLPKGLLEDHTSEGKLWDPIQGAYFYSFDPASNTIESVEGSPTGFMNFKGRWGDDEYADGDHGQKNFFGFKKYTAGPTGPLDKNLFRKQVCPDRIQNCDIKSELAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P088</accession>
    <name>A0A0B1P088_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative la domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002370">
        <property type="protein sequence ID" value="KHJ32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P088"/>
    <dbReference type="STRING" id="52586.A0A0B1P088"/>
    <dbReference type="HOGENOM" id="CLU_005100_0_0_1"/>
    <dbReference type="OMA" id="WPTPQVA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="653"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125069" checksum="FFF5BA563B018EEB" modified="2015-03-04" version="1">MMSSTAIKFMGEKSAGPPVFSYAQAAKGRTSATAAYAVQMNQSTMNSSIASTKDTNSLASTPSQNSVREDRSAIESIEALSRLETPTETLALESKTIHSELTESPLSTPEFLSASVPSSKENEKEDDYVSVESSSGIVREQNSIGKKGKKQKSAVDEAEKEEVKPEVLVPAPLPAVNFWQQRKEKLAKLISPPLTKNTKATVETNNSVEGPHSLNIKTAEFKKRGKQLAIDINERHIASNQNGLTRESTISSRTPKKSSNLPSKFKDEQSNKRNGTRGGKLTEKDDKSLGTQAPPPVEDASSWPTPETVLIEDKRKVQEKQDRDDKDDNTSNKPRQKEKWVPVPYIPTVTFNTPLPSRGGRTRGAGRSGRSEHEVRSNHGSNGVMPTEKTHNVASESTNSATEIDRANAREGSSVTASSLRRQSGDNSNTRKLSNAQLADKTGSNHAKGDNIYPNESLNLKNTQSGPNFEENRDSRNHTAEQFNSLKLAQIQSKDVSGMSFTERRIESSARHSDHNHIGRENSHSTRERIEGRPERGRGGFRGRGSHSSYVNSHSHHSNFTNGASSQHQNSYNVRQAPYSPPLIPPYNNQFVPPPRANRVGPRSQSIPSNGTYGRFSQNGGNVPQPLTSLQTSTPIYDYAQIHPMSAPPYQPYIDQVSVFAMVTMQLEYYFSIDNLCKDVYLRKHMDSQGFVYLSFIAGFKRIVALTQDFELIRFACQESEVIELVRGEDGIDRLRRKEGWEKWVLTVEEREDSMKNLSPSFWHPPQYAQKLQHVGQMVITSPHPACMMSYSMSESSYPPYSKDGSVVPSINKNDGYQPPTPLSAAVPDFAPSLPPIDISNDLLEAENTFHEDEVANLTLVFATPDVSNGNNDMQPLPSYYHTSSRTFSNGSLDKRIIIEQAHKDTYSEEKVIIEAPHQNDNALESLPLPKSSQSPTRSDTSNSPPVMWVKGERQQVPISERNSQELYITFRARALRNREISLLTTTEIHPDMNLLYEFWSHFLCRNFNSQMYSEFRRYALEDARSGSLNGMHKLINYYDEALNSKKKVIPEILARHFLDLVKLETSDERPAFERLRAAWRNGALDLRSRKRIDSLMNSRLKQELEQAPFQKSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L7</accession>
    <name>A0A0B1P0L7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002248">
        <property type="protein sequence ID" value="KHJ32202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L7"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="101" mass="11309" checksum="20DC3F90474C3F72" modified="2015-03-04" version="1">MYRSVPEGTSQRGGHYSVNANAFLPEELAEILVIRQSRERAWHTRLMICATVISNTEITLANFTKKVEKEEVVALKAYLRMAKAKYVAADSSPAPPKIPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0N7</accession>
    <name>A0A0B1P0N7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mrt a raffinose family of oligosaccharides transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g3584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003553">
        <property type="protein sequence ID" value="KHJ30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0N7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0N7"/>
    <dbReference type="HOGENOM" id="CLU_855792_0_0_1"/>
    <dbReference type="OMA" id="QASNIEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="110"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="368" mass="40595" checksum="1CE80ACFC62A2078" modified="2015-03-04" version="1">MVNTVVNKMVSTMVNKMVNTMVNTMAVLNLAAIIFSLYSNLCLETTDETGLSVLAATPKQGADDNPASCLEQGQASVDNDATPAKTRAEKLEREMSVTASWKLWRPASYWSILLSLVVIMEGYANLLLAQFYAMPTFCQRYGVIGPYGTYEIPTLWQAGLSIGCLAGETFGLCTSAIAVDRLGYRKTMIISLLALVAFVNIIFFSQSLVVLLIGEILCGVPLGVFQTLSCTYASDVCPMKLRPFLTTYTNLCWLIGQLLSSGVLRMLVGRSDQWSYRIPLALQWICPLPVAIAIFFAPESPWWLVRHGRTEDARRALTRLTNSKDQPSAFSIDDTLSMVSLLIISFHNLVLEKPLVSAQASNIEWPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P3</accession>
    <name>A0A0B1P0P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003542">
        <property type="protein sequence ID" value="KHJ30840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0P3"/>
    <dbReference type="HOGENOM" id="CLU_036462_0_0_1"/>
    <dbReference type="OMA" id="VGTHPKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="392" mass="44326" checksum="3324C6FD93D32AF7" modified="2015-03-04" version="1">MVVRLGVAMMPYNTRRKLLSLPSLGIHLPVSHATRATAQTSPPSAAGAVVNMEVPSKKIKRSHNQSPSSTVNHSKRVPTKYENTPPPSPTAESDEREVNWFKPISIDVKSIKDEIVEAVILQLHKTGNRPHLVKELATILSRSVKIVEQSANPSAIVSSRLSAYIKRSWSPASPCPISKVLETVHPRRTHYYLTTYPHQSVSDLSNRISTARAIISPSISSAASRYDEIDTDRRRELSPSPEIDLFPPEYEDENQDYQTRPSAYRFSCQIKQMPRTLRSTSPPLEKDEKEFTQAARGMQKRKFGDVVSSGVPSEIEEFTPKNFESESFFEKQSFHPSNHDFLSSPDLKSGTFRRNNEESNFTWLQIEADAKWDMRCPELVDLEELDGMFDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q2</accession>
    <name>A0A0B1P0Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004102">
        <property type="protein sequence ID" value="KHJ30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Q2"/>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="28783" checksum="D04902880B8A10F8" modified="2015-03-04" version="1">MSTSALPALKTNPKFIFFTDFDGTITVNDSNDYLTDNLGFGQVLRRQGNINILDGKQSFREALQQMLDSVQLPFNECIKVLEENIKLDPYFPEFFEFCSMNNIPIVILSGGMEPIIRALLHKFIGEDASSIQIVSNDVISRDGKQINEKGGWKIKFHDDSDFGHDKSREIKPYANLPPNKRPTLFYAGDGVSDLSAAKETDLLFAKKGYDLVTYCLREKVPFTVFEDWSTILSTVKSIVSGKTTVKEVSLAGMEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q4</accession>
    <name>A0A0B1P0Q4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="JNVN01002231">
        <property type="protein sequence ID" value="KHJ32232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Q4"/>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="449" mass="48965" checksum="A65219F7719EEAFA" modified="2015-03-04" version="1">MSAPAHKFKVADLSLAAFGRKEIELAENEMPGLMATRAKYAQDQPLKGARIAGCLHMTIQTAVLIETLTFLGAEVTWTSCNIFSTQDHAAAAIAAVGVPVFAWKGETEEEYQWCLEQQLVAFKDNKHLNLILDDGGDLTALVHKKYPEMLKGCFGVSEETTTGVHHLYKMLKNNTLLVPAVNVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKIAVVAGFGDVGKGCALALQGMGARVLITEVDPINALQAAVSGFQVTTMEKAASQAQIFVTTTGCRDILVGKHFEVMPNDAIVCNIGHFDIEIDVAWLKANAQSVQNIKPQVDRFLMKNGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQILLFKAQDAEFGTKYVEFGKTQKLEVGVYVLPKILDETVAKLHLAHVNAELTVLTPVQSEYLGLPIEGPYKSDLYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S9</accession>
    <name>A0A0B1P0S9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative inner centromere protein mis6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002568">
        <property type="protein sequence ID" value="KHJ31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S9"/>
    <dbReference type="HOGENOM" id="CLU_1564043_0_0_1"/>
    <dbReference type="OMA" id="THDTVED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="171" mass="19453" checksum="3743A5C9217FB49F" modified="2015-03-04" version="1">MEDHSVEPQSEFSNLLADLEQAAQKPAKKRLTKVSIVIDKINSKSYQNGLSALDLDKLIDIIILPNQLDQSSRINLIRNLYPIDKISKSVFFRVVASLGHGITKAPYSTQAMLLKWLIMTHDTVEDPTVFSQVYSILFNLLDTAAIRSQLCHLLSIITRRKHVRPFRIQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B2</accession>
    <name>A0A0B1P1B2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002398">
        <property type="protein sequence ID" value="KHJ32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B2"/>
    <dbReference type="HOGENOM" id="CLU_1644978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="17597" checksum="770C661B415BDFE0" modified="2015-03-04" version="1">MLDCYHVGTPLDLGTQLGKEQKEEKVDDHTIYQSIIGSLMYACIGTRPDLAYAATLLSQFSSCLNKTHLTDAKRVLCYLKGFMRIIVPNLNSDSSSSLSPSEESFQTALGLLFSPSLISIFNMLGTSKGFDIEMGEANANALRGLSAEDILELVILLAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1E3</accession>
    <name>A0A0B1P1E3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative bzip transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002381">
        <property type="protein sequence ID" value="KHJ32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1E3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1E3"/>
    <dbReference type="HOGENOM" id="CLU_034316_1_0_1"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="410"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="57237" checksum="8C9B7DE1B36A08E1" modified="2015-03-04" version="1">MVSSPTVSTAADVTSPISSKRESPKQNNLIRKPDDIKSEKKESLAPPPRLGQPSVQSADYFSSSHSHLASEANPFDFSFAGGSSGNTNGGNIQTPGGTRLPPVSNLTSPAGILGPGITGAYWGANSLRSGPVSPAMIGGPQKPADDYFVDGHHIRDLRSGFITANESALRSGFTPEAESNVRAGLTPGGSGTMFPELVANPPTSIYNSMTNAAQTPSTIEFHRVAINAQKRNQPPQQSNTTSQPQEHVNAIDVKPVPCNFDDANAAASGLFLLAQSRESSQSNNQYALTNNQLPIHAHPVIKKNDKDDKSTENSPVLQHRKGLSISNSSRGDDSASENDVNKSQLRDQSKKSSPGTSGRRKASEVSTKASSSKKAKINNATSQVTENPTSEDDTGNNSEHGTDGKKITDEEKRKNFLERNRIAALKCRQRKKQWLNSLQAKVEVYASENEGLNAQIQALRDEIVHIKTLLLAHKECPVSVAQGISGMNMHQLMNEGGFTAPINPYGINATLNHQQSQQHVVNGRNLQQRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1L8</accession>
    <name>A0A0B1P1L8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="7" type="ORF">EV44_g4863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003724">
        <property type="protein sequence ID" value="KHJ30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1L8"/>
    <dbReference type="HOGENOM" id="CLU_026505_1_0_1"/>
    <dbReference type="OMA" id="VPGYRQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="395" mass="44581" checksum="EC4A30EC9FFDE8CE" modified="2015-03-04" version="1">MLDFMDYIKNTWHSASQWNQDNSYSQLTSTAKDLLEFEPPRGLRLQLSSLSSPNFATSYSLCSTGLVDGSISYLYSSIKLYPLFKTSKIDLRHIIRSYKQIQELCESKDSQSDEPWNKGEKLVKKGTLMYGRMYLPQTTLEALYIRRLSPTQQLSVSAVSDSCLKNKGTILALHQYDVGKYSVETLYSTDGGLIGVRGLYNFGMDTRKGKKILVQNEDRFYGRFSIGAEIYYGGLNKSGGMSFGGKFATLPTHKGIPIITTFTLNPLMGNISTTYAVKAGKDISLCSKFDFNFYSYESDFVLGAELWRMKNKSPPLGERSMAAKLQWRQDSAEEKIKAQEEISGVLKVRADQNWRIGLLWEGHVKELIFSLGSFIDMKRLDQSLGTIGLELQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1U5</accession>
    <name>A0A0B1P1U5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003534">
        <property type="protein sequence ID" value="KHJ30851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1U5"/>
    <dbReference type="HOGENOM" id="CLU_2122890_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="13010" checksum="AC4BFEC3FC2DEB09" modified="2015-03-04" version="1">MNNRAQNRHIFIVEIVTVVALKVMPVTIASIKERHIKFIRTLNDPLGSLGKKILKGEMKSSLYRKIFSLVVGAIFWTSVSIYFACILCRRSLVRDSGIINETMIMKKKWKLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P218</accession>
    <name>A0A0B1P218_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002973">
        <property type="protein sequence ID" value="KHJ31345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P218"/>
    <dbReference type="HOGENOM" id="CLU_1469269_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21381" checksum="32C5868F130E26C2" modified="2015-03-04" version="1">MTKTINETITEAFSSSHLNPQSSLQSRNHTDNNSTHTITLSQQPQSLASSNIKNVWQPEPGLIPAFDKFNGNTDILEYIKDLETRFLLLPNLSSTDRLKVIIAVENLTGSRENQTDAPKQWARVELRFDENLRDDWPAFREKLRSRYQNVELRKRLVEERQALKQLSLTIQAYKQSFEQLCYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C8</accession>
    <name>A0A0B1P2C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative microtubule associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001804">
        <property type="protein sequence ID" value="KHJ32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2C8"/>
    <dbReference type="HOGENOM" id="CLU_041744_2_1_1"/>
    <dbReference type="OMA" id="WIKRFWD"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099609">
        <property type="term" value="F:microtubule lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030989">
        <property type="term" value="P:dynein-driven meiotic oscillatory nuclear movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="250" mass="28203" checksum="1D6789BB3E6984AD" modified="2015-03-04" version="1">MGESRQELVAWLNNLLSLNITKVEQCGTGAALCQVFDSIYQDIPMSKVKFNVNTEYAYLQNFKILQNCFTRHGIERPINVELLIKCKMQDNLEFLQWTKRFWDQNYPGGEYDAVSRRRASGAPISVSSNTPKASSMAGRRGATPTTMGRPIKGNLGISALQQENAALKDTVQGLERERDFYFSKLRDIEILVQQADEDEAFPDKDKEDETNGGTEKIDGLIQQIQTILYSTEDGFEIPSDAEGVDDHETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2I0</accession>
    <name>A0A0B1P2I0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2886</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003544">
        <property type="protein sequence ID" value="KHJ30839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2I0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2I0"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="33"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="408" mass="44257" checksum="3A71A06C4CF31EAA" modified="2015-03-04" version="1">MFVQLLKPKSKTIFSEQLVNVKSTTPKIPEGIEGIIGDTPIFKIKSLSEATGCLIFAKAEFLNGAGGSPKDRVALNIIRTAEAQGFLSPGRGDTIYEGTVGSTGISLASLARALGYKAHICMPSDQSKEKEDILKCLGARVERVTPAPITSDEHFVNLAKRRAIYHTQDNFESRGFFADQFENSANFNAHFSNTGPEIWNQTGGHIDAFVTGAGTGGTISGVALYLKQKMGLGKNLRVVLADPEGSGLHNKVKYGVMFSNSEKEGTRRRNQVDTIVEGVGINRLTNNFEAGMELIDDSVKVSDLQAMKMAKWLVENDGIFVGSSSALNCVAAVVVALKMPKNSRIVTILCDNGTRHLSKFWKKIAELEPDVGLEGTDLFNILGIKDNIDKRETFDAIDIKSNSFCCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W3</accession>
    <name>A0A0B1P2W3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator medusa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001938">
        <property type="protein sequence ID" value="KHJ32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2W3"/>
    <dbReference type="HOGENOM" id="CLU_013895_0_1_1"/>
    <dbReference type="OMA" id="HSENWIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="394"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="672" mass="74747" checksum="D874AAF421AF78E0" modified="2015-03-04" version="1">MSTYGKAPKTHNHELYEIGRSYHDPHPYTTTMYPSQSLGLPSVLSGYTNLPQSQSTPIPYSLNELRPAYNDPPISYLDISSPSPQLTLFSPSKGSEYSTIHIEFTTVYDITTANFPGLYITFGSCKRSANAHKIPPKNSSHSYYVAADVPSFSTTGWSSFIVPVTMTMELKDGTLISKMFIGEFEYIDRHESLSGSNRSNSSSSGVCSLSSSTSESNKRKASGDLLELMNSPRKKLPYYHSRSKEEYSNYQYNGTGSSSLYSYLPNTSFYMPPVTPSYGGIQTINFNGGQVSTKPMQYENLGPGATTSPMSKASSPPPQNWSSSSLRKNVRKSPGISPTSTSQQDSIPSKSPPSLLVNPPLFRTSTFHQTSSPADTPHMKNYKQFNSYSLYPHKAKLEIIGDLNSMAQSWTDEEINCRRRLVLFKRSQSGSTITTNFNSIRLDDRPKDSICISCIYWEEKRDFFITSVDTIYLLQKLVAAQFTVEEKNRIRRNLEGFRPLTVSKGKTESEEFFKIIMAFPAPKPRNIEKDVKVFHWSDLSSALQKIIGKYSASPSSILNTVSTLTPISTSGYTTESSTGRSCSNEHTRSSSPRSFSSSATSNTAPSTRLMSPLSNEKSNCMTVPMFRGGENDIQIFPDINQSPWHNSPHRFQSSRVLLHAQGDYHNQILGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Y0</accession>
    <name>A0A0B1P2Y0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003319">
        <property type="protein sequence ID" value="KHJ31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Y0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Y0"/>
    <dbReference type="HOGENOM" id="CLU_037358_0_1_1"/>
    <dbReference type="OMA" id="CNNYVEF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058846" evidence="2">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="453" mass="49406" checksum="343F2BEBA1FB1CE9" modified="2015-03-04" version="1">METLTLLFLLAATVSSVATEDTTSIPESLMTLTGPAVSTVPTGSYQTYLSTLTVTPSPISTEAIVSTITDDTSTRTITIGLTTILGIGTNAENVTVEILSTQTQTLLTGRPSTTSNGTTNSTSSSPTPTPTNDTPCNNYPEFCSRKFGNITEVSAHNSPFIRAGNAGANQALSVTAQLNDGIRLLQAQIRFVNETPHFCHTSCQILDAGPITEYLGEVQDWVSSHPYDVVSILLGNGDYRPVTQIAPYVEESGLVPYAYLPSKIPMMKDDWPTLSSMILTGKRVLFFMDYQANQTAVPWIMDQFSQMWETPFSPTDRAFPCTVERPPGLLPPDASQRMYIMNHNLNYEISILGNSLLVPNLPLLNVTNNVTGYGSLGENAQGCNDTWHYPPKFLNVDYYNIGNGSVFQVAAKFNNVTYDRECCGRVPNASSNFRQSISSLLLISLLISGFFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P304</accession>
    <name>A0A0B1P304_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromatin spt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001639">
        <property type="protein sequence ID" value="KHJ33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P304"/>
    <dbReference type="STRING" id="52586.A0A0B1P304"/>
    <dbReference type="HOGENOM" id="CLU_049218_0_0_1"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="35231" checksum="E9A341C68D8827AC" modified="2015-03-04" version="1">MPIGDLLAQITGNPGSDTKKPSHQEINLLERKSEVQTQRLLSKTRDTSKPRNAIRKTMSLGKSETPDRLSEIKPSRDESVRNNKNALISINSKAASIIQNRESKQPKKGSYAEIMARGKAAHAILGQVGRITHKNIEKPPSKREREEMKTLKSQKKTKTSDSSEMSRRLDNGRERSSGKINLEPAKKIKKSALATTGYTGTARPKSNSLPTMSRASTTSSSKKDLDIRRSSSRSMNRYLSEDEEEYDEEDQYYESDLSDMEADTFEVDEEEEIAAKIARREDAEALAEENRLKREKEAKRKKLAAMAKSRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P311</accession>
    <name>A0A0B1P311_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative spry domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001627">
        <property type="protein sequence ID" value="KHJ33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P311"/>
    <dbReference type="STRING" id="52586.A0A0B1P311"/>
    <dbReference type="HOGENOM" id="CLU_009129_2_0_1"/>
    <dbReference type="OMA" id="LPTRWNK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="154"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="431"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="663" mass="74449" checksum="BAF5D58C7B4C68DC" modified="2015-03-04" version="1">MSQSYGNPTRTGVYLDFLNQSIDTRYDLSNPSAAPSRYDSEATEIESSLNAINRIRSKSRGRGGHLPHLINAFGTLGDGSTSNCLLTGQGEGFFIPSYLKGSVYIQRLQKEYEAKNVSQKNNSSTHSSLAGSLSKSTSSTNLNARMAPSHRGMTYDLIEKVPSYEYEPLPPLPSKWNNHDKQAALEVLSDGLELKLSTQKPERDREIESCAIRANHPMPSQCGLYYFEVSILARKREESTIGIGFSSKKVPLTRPPGWEPESWAYHGDDGDSFCSQTSGKGYGPSYCANDVIGCGVNFKTKSAFFTKNGIHLGTAFKDLKGEFYPSVGMKKSGEHIRVNFGQTPFIYDIDGMMEREKILIEHEVNAVSTDKVAPPLRETELTQALVLQFLKHDGYVESAREFAKEVYFEKKALSLNPETILPDYDIKEEEDTSHRQRIRSAILDGDIDAALRYTNLYFPQILKDNEKVYFRLRCRKFVEMIRKAAELQNSNQENGTKKCHKYDTDWYDDIINHQMEIDGNDPLSQTYGLLERDDTSKDLSEHEHLLNETIKYGTELSAEFRDDPRKEVRQALEDAFALMAYQEPLNATGVAYLLDPSGRVAVAEELNSAILQSLGKSSSSFLELIYQQTTVLLEGLREQGGSAAAFLNINDYSKPKPNMGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P331</accession>
    <name>A0A0B1P331_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="JNVN01003011">
        <property type="protein sequence ID" value="KHJ31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P331"/>
    <dbReference type="STRING" id="52586.A0A0B1P331"/>
    <dbReference type="HOGENOM" id="CLU_016734_1_2_1"/>
    <dbReference type="OMA" id="FRAWIVR"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="360"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="712" mass="77077" checksum="A89945FF5A712663" modified="2015-03-04" version="1">MECLKLKFDQCKRESRAAFITYVTAGFPKLNDTVDILLALEAGGADIIELGLVFTDPYADGPTIQKANTIALKNGVTLGSTLQMVKSAREKGLKVPVVFMGYWNVLLSYMDKHGGEKLISDCRKAGVNGFIIVDLPPEEATNFRKFASHGGLSYIPLIAPSTTTERMNHLCQLADSFVYVVSRMGVTGATGSLNPQLPKFLNRVKNASGGVPTVVGFGISTREHYQLISSIADGVVIGSQIVETLFKAPVNEGPTAVKNYCAQVCGLSSRSSLVQNGNTSHPNKAMQAMNDPVIGMTSQVKSLNTNGMVSDQTRFGEFGGQYVPESLMDCLSELENGFNKIKTDPEFWAEYESYYPWMGRPSQLHMAENLTRYAGGANIWLKREDLNHTGSHKINNALGQILLARRLGKTEIIAETGAGQHGVATATVCAKFGMKCTIYMGAEDVRRQALNVFRIKLLGAKVVAVESGSRTLRDAVNEAMRSWVVNLQNTHYIIGSAIGPHPFPTIVRTFQAVIGKETRDKFFKLRGKLPDVVVACVGGGSNASGMFHPFSEDLDVKLLGVEAGGDGLNTTKHSATLTSGTKGVLHGVRTYILQDEHGQISDTHSVSAGLDYPGVGPELAFWKDTCRAEFIAATDAEAFIGLRTLSELEGIIPALETSHAIYSAIELAKKMEKGKDIVICLSGRGDKDVQSVAEKLPTIGPIIGWDLRFEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P360</accession>
    <name>A0A0B1P360_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rare lipoprotein a-like double-psi beta-barrel domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001862">
        <property type="protein sequence ID" value="KHJ32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P360"/>
    <dbReference type="STRING" id="52586.A0A0B1P360"/>
    <dbReference type="HOGENOM" id="CLU_052701_0_0_1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31107" checksum="0943DAAA2DE1C6BE" modified="2015-03-04" version="1">MRAFYLLFAAISSQNVLSSPHRHLHNHHHAARHVKREDDSPVTTWVTEWVSVLKTVEVTTTMWVTPSVPEPTHVKNVNHDVTTEIPVDDAVVPSPAPAQFFEPHPTPLTESSPDLKDDMNLEATPSSAISFNNDKVELPQTQNEVVKETIAPLTVDDEHDSMISNDTKTALVDHAASAGQCTSGSPCNGDITYYDPGVGSGACGWKNTKDEPVVALPHAFMGEKSNGNPYCGKTITIVHNGKTSTARVVDKCMGCTGFSIDLSDSVFSQFEALSVGRTSAKWWINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P371</accession>
    <name>A0A0B1P371_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003236">
        <property type="protein sequence ID" value="KHJ31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P371"/>
    <dbReference type="SMR" id="A0A0B1P371"/>
    <dbReference type="HOGENOM" id="CLU_029060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061790" evidence="1">
        <location>
            <begin position="19"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="590" mass="67863" checksum="C9B32E8B98EFA003" modified="2015-03-04" version="1">MRFPVFFVTFLRLRKTFAVHPSEGLLSDRVESTALPDRNDNKGYECGNVFFTYSETRQALQLYHQYLNRNPAFVIQENTSPQVTPQKFQALDNYVPQQNVDFPGNSFPQESDVSLNFDIDKEIDNLKEFNDQNYYNIFDDFNVQEYDNAQYNYGLKKRNDFGKGCVPREYHGRLYGDADTSKYILWPIVRENLTPFPSPINPFYIVIDRNGDNIIDVIASMANGDYIKCIRRDSSLTNFSTPGPETTNGYVCTHEFLSDGLITNSLMLAKKNGVKNSYYPKPYFGNLYPRGKSYKLWPIFARRKLYRGGSSPVEPFFLIINKKYELVDVVAKGVESNFIRCSRSYKIVTISIPDTPNVAKRSGFQCGKLFFDIEDIKRVGSEAKGSNFLRKSKKLPQEYDGPPFNEPVLLWPILSTKRGYKKGSLGPYRVVLTPDHKIKGAAYYLNKKIRKCEPRKITGQINHDPNDYYCLDFILRNQHLIRSTKIGCSKMTGKTDTHFPALYEGPKFEKVGPYFTYPVYEINDFKTNAGLHRVVFNADCEVVGALTTMLVNVNTKADRQLVKCIKLKDSETSFSSFDPENPISEHRFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I6</accession>
    <name>A0A0B1P3I6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative heat shock protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002829">
        <property type="protein sequence ID" value="KHJ31511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3I6"/>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OMA" id="PQWQPKF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="40"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="166" mass="18869" checksum="A37DC94B4E1A01A2" modified="2015-03-04" version="1">MALFPRSYSTSERSSIPPIIRLLDEFDQYSRKVDRSNQSSNNNSFTPRFDIKELSGSYQLYGEFPGIEQKDIEIEFTDASTLTISGRSERSYDDRSGSNSTKKSEATKETDSTFWVLERSVGEFSRSFGFPIPVDQDGVKASLKNGILRVEVPKTKKQESRKITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K4</accession>
    <name>A0A0B1P3K4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002823">
        <property type="protein sequence ID" value="KHJ31531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3K4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3K4"/>
    <dbReference type="HOGENOM" id="CLU_003925_2_0_1"/>
    <dbReference type="OMA" id="LWARYIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000588">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="572"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="648"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="739"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="867"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="969"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1029" mass="117504" checksum="C6184F8F48D4DDE6" modified="2015-03-04" version="1">MPDPTGEEDWLALTDEIKRNASDLEKCVEVVECYKRAITIEPCSIKIWLAYCEWFWSLYEKCQTTKTGWSEEELELGKEIFNIETALDVWQQGAHATKYRLNDSHELWNRWISIELENLSESTDEGKIKHIRGLFIDRLQIPHATWDDTSQMFSSFLTKYSESTWEATMIEITKIAKEAKEIFRRREQFESKLKKAEESGSAEAVKTQILDYLSWEQNQALKKNKKGTLTKYIILCVTLFERALTSTQLTIDPTLWEDYIVFLLNTKSDHFNNELPSILSICHRGTTHCPWSGALWARYILCAEMEPLPFASIERIKHAATNTRELDRDGMNDVILFYIAWCGYLKRRTMIEGATDEDHDLAEMGLPTALEDVTQWGIRRLGKSWKGDPYFRIETILIENLTERLALEEARGLWQGLVATHADSYDFWYQYYQWEMIVRDSKKPPTLATAVLATALRHKALDWPEKMMEVYVKHCNNHENATVVLEAINMVHRVAKGVIKRREREAAMYQAEFVNPGAEADCISNQEDQESVSERNKRKRENDEIESTSKKKKTIDQATLQEKNLKRDRENTTVIVTNLPPEVTQTKVKNYFKDYAHINSLILKTEIDNKSSLALIELRTREDVQSALLKDKKYFGDRQISVIPAIGLTLYVTNFPPTADDNYFQKLFKDCGEILSIRWPSVKYRTSRRFVYITFRTLRGAEAAVQLNGLSLGDIYKLYVAYSNPNIKKDREGATAESREIHVTNLDTSLNEEDVKKTFSKYGTVQKVNILKKLSGKSKGAAFIVFETKEEASAALELDKTKLKSSVLSVEISKERNFKPIATIVNKDSKAIGIDNDTMKSPQTDLENFNTILAESKAPTSSEIAKRTITLLNIPDTINDARIRLLCSSFGEITRLVLRPDHQGAIIEFSNSISAGKSILGLENYEILPGQRLKTGTLKDLFADKNTDKTKFGQSKKLPTRLMQPAASIRRPTAPGSVKQGKKKALTQFKSSSINTENTVFSKSNDVGEDKSKKQMSNADFKALISSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W2</accession>
    <name>A0A0B1P3W2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001485">
        <property type="protein sequence ID" value="KHJ33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3W2"/>
    <dbReference type="HOGENOM" id="CLU_1644976_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="18049" checksum="3F170DA26E7A68B3" modified="2015-03-04" version="1">MNWTRRSQNDEPTGCIRISVPESKSNKFPSRLRIFGEAVFVQRIRPRDQPVVCTKCHGFHTARKYARNPKCKTFSSDLHDGPCIKPIRCLNCCGPYTSDDKNFPARPRRINGVFVRPTGAKLHQIRTAGGREFAKTNPQSTLDSSQLSPSSLATESLVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4M9</accession>
    <name>A0A0B1P4M9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002521">
        <property type="protein sequence ID" value="KHJ31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4M9"/>
    <dbReference type="HOGENOM" id="CLU_1723675_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="152" mass="17224" checksum="7D5E7190C0FEA516" modified="2015-03-04" version="1">MKPIIQPHSDNRVPIKHPQLITVPKTTAMASIAGKNEPKSSKSVDWKIVSHRGTKNKNARDTRPGQVKNAEESKCRKLFTRKVENTGRLISTAQNILHAANLILMVMKASALLRLKRLRFNDRGSLMGLTSSETTAETMITRFKKYIYLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4T2</accession>
    <name>A0A0B1P4T2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="JNVN01002667">
        <property type="protein sequence ID" value="KHJ31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4T2"/>
    <dbReference type="HOGENOM" id="CLU_033449_2_3_1"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="10">
        <location>
            <begin position="289"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="445" mass="49279" checksum="0C8956426A047376" modified="2015-03-04" version="1">MVFIIRNYKTINRTNPSFYFLKSLARMATLSLLKKKHKVTVIGSGNWGSTIAKIVAENTIEHPELFEEQVQMWVYEEEITLPQESKYTSNNEKNPQKLTDIINTYHENVKYLPGITLPLNVIANSSLIDAAKNSSILIFNLPHQFISKITKQLEGHILPYARGISCIKGVNVTEAKISLFSEWIGQGLGIYCGALSGANIASEIAREMWCETTIAYDPPSVDSRVTTPVNPSPMSISINNSLDSIESGLVNRSGKRNLMPIPSEYPPLDHSVFKALFHRHYFHVRMVSDVAGVSLGGALKNIVALAAGFVDGKGWGDNAKAAVMRVGLLEMVRFGKEFFGQTVRTETFTEESCGVADLITSCSGGRNYRCAKLSVEQNLSITEVEQKELNGQKLQGTLTAKEVNVFLKARGREDAYPLFKAVLDILENRNTVDDIPQLLSSASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P572</accession>
    <name>A0A0B1P572_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rrna processing protein ebp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P572"/>
    <dbReference type="STRING" id="52586.A0A0B1P572"/>
    <dbReference type="HOGENOM" id="CLU_036007_2_0_1"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="43069" checksum="5D7C9880F216A075" modified="2015-03-04" version="1">MVSKSKLKMALLAEKAVDLKKLSIKKKEKASRKRKSSKVKDVKHDVNKSDNNDEEVEENEGIEEKEESDEKIKEKTIDGKDEETNSNKKVGNELVETEKTDKNSAAEDESEDDEENEDIPISDLEDIDHEDMEDLIPHQRLTINNTVALTAALNRISLPISELQFSEHQSVTTSEPVSVPDVSDDLNRELAFYAQSLAAVKEGRKKLKLEGVPFTRPNDYFAEMVKPDEHMTKIKSKLIDEAASKKASAEARKQRDLKKFGKQVQVAKLQERDKERKSTLEKIKVLKRKRQGITAENETEADIFDVAVDEEIKSMKNSKDKSTGVRKRQKKDEKFGFGGRKKFKKSGDAFSSGDLKGFSSKKMKTVAKNRPGRARRASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P576</accession>
    <name>A0A0B1P576_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002335">
        <property type="protein sequence ID" value="KHJ32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P576"/>
    <dbReference type="HOGENOM" id="CLU_758597_0_0_1"/>
    <dbReference type="OMA" id="EDHIFAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="39284" checksum="0DE41ACFCC722CCB" modified="2015-03-04" version="1">MEIDTRFKTLEKTIELGHVNTNGRIEKIEQRLDKIETRNTNIEKIVIQIQKTLNSQLRNQEDPKEPKEKSVQKEEKSESIKRDNQGRIQLSDFQNTDNLTISEKFVKRAWPEAIFPRDIQDDAYASVKNKVVLKPEWRLVVANVEIFDKLLLIQNALQMALIPYHMWAKRVAMDMGGDFHGVRVWSSGRNLTWIELLEAIFTTMQRLNVLHSPFTTFSLIIPNKNESPHAFAWRLREAFYKLSGIDRDSDSTRELLKELIMNHLPRIWTLTYQNIKSSNNYEIIEMAVQMASQVVKWSTEDAMPLTNTIEPPKNIIPHLESPSFPNSEENSFLGPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P591</accession>
    <name>A0A0B1P591_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001204">
        <property type="protein sequence ID" value="KHJ33837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P591"/>
    <dbReference type="STRING" id="52586.A0A0B1P591"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="334" mass="36720" checksum="DFD99175E2679C16" modified="2015-03-04" version="1">MELDVDSIAPSTTARSTPSTPLAPPAQPPLPPLTTSSNIVVNEEGKSSHVPRTILDPVAPSKRAAQYFTDGMTQSLRDEAQHAPAYLPKELQAIIQRRQDQERAWHVRLSKFASVICNVESTLEMYKRDIEKQEAEFIRNYIRKAIARLASSDNSPKPPQIPMNTKPCQTKDRCQEKDSEKNNPPTGLYKPPKDTPGQNSWAIVARNGHKKSRVTTTTPLVSKNISTGDQQKPSTSSKSTMNKNIKSKNAKEISPDSRLLLRLPANHEWRNLSPADIREVIVKCLAVSPASIGLIKPVRNGFAISTSNSGAREALLQIKIGLLDTGAKLEPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J6</accession>
    <name>A0A0B1P5J6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dead deah box dna helicase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001364">
        <property type="protein sequence ID" value="KHJ33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5J6"/>
    <dbReference type="HOGENOM" id="CLU_044364_0_0_1"/>
    <dbReference type="OMA" id="ILREMEF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="369"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="520" mass="57348" checksum="CF81831DE6C27749" modified="2015-03-04" version="1">MFVSGENKTKETVVLNLAPKNEPDDSDSLLTASKEIHHKKSTGHHSEHSRPELPIMEQSQNEENELPKNSISEDSPQATDLAPQTQEMMQNLLPKKKRSRDQIEERKDLDNQEVDKSENSDESNVNCTRTSSSEPEKKRARDKSEPIEYPTNQNEAANKLLPTPKIIEVVENVQDNNQVEPKPCIIPTLSDQPEKTKLTFASSGFASLANSSVSPFGSLGMAKLSVFGGGVNEGSGSEKSVISSNFTVSNSGSSSNDQLGKEEPTSINFSGKMESGLKHVAGENKFTSTFSSSAFSTNSGVRLSSFASPGAEIPTFKSKEIREFGAPETSAINYESETHNVTKENELGNNKNGENTLVGHDESLTIKKKIDDGEADEVTILQIRAKLFAIESKKSGWKERGVGTLKINLPKNSVQYDEKGNPISGSYKSSIRKGKHNNETNSAQAARLIMRQESTHRVILNTFILREMEFEEKSAVSSAQFLFTAFEGEKEVKPVRLLLKMSELNSKLFRSEIQSIKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P641</accession>
    <name>A0A0B1P641_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ubiquitin conjugation factor e4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002108">
        <property type="protein sequence ID" value="KHJ32396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P641"/>
    <dbReference type="STRING" id="52586.A0A0B1P641"/>
    <dbReference type="HOGENOM" id="CLU_003224_0_1_1"/>
    <dbReference type="OMA" id="WLTEIAM"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="972"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1063" mass="121360" checksum="6F081B66C54C037B" modified="2015-03-04" version="1">MDSNFTPADLASDALDKDKMDQIRRRRLEKLGGNASKSIGRSEGSGNSLPTAIKSGEISSLKANVNNASPTPSIIENPFAKLTKQDTSNSSTIRPKAKKKVLEETIEAYENKVLSSIFYITLDPEKNTKLPNQKLIYLSNLRKELDDEGAPTLLSQDKLDSAILEAASVIPTHNSVLGYLLPCFKRVTKAINGLRENSDAKLAILKEAERLIICYCILAIDEPDLFGRSPNPVRDSLVHYMILDPSLEESADFSFIAKLATDFDENESVKSILINAAIDLSRQLSNLTMNDNFKPYINALKILCQESKIITAISRHQSFYSNEEPVRGIEKNTFLGPFFHISPIQPEISLQYFSNVKSMNTRMINTAQEALRLTSQAHQRDLLDITYLFVRANVEARNRTLDWFAYVLNSNHKRRALRPDPTTLSTDGFLLNITVVLNGLCSPFMDVSFSKIDKIDTQYFRRKPRICITEETKLNADQEASENYYKFSLDGSPNFISEVFFLTLAAHHYGSGGTISMLKSLDKDIGFLEQKIFQLEQERDKIASSQSLLRFEEQLNKFRDVLDKSCSLKYACEAVLFDRTMQAKSLIFMRYVSVWLLRVATCSDYTPDKTIILPLSSNIPDVFRYLPEYALEDIVNTFIFIFRHIPDITISSIDDELVVLCVTFLESDYIKNPYLKAKLVSLLFFGTWPIHHLQKGVISDALIGSKFANDNLLHALMKFYIDVELTGAHTQFYDKFNIRYEIFQVIKCIWTNDVYQQRLVQESKKNIDFFLRFVNLLLNDATYVLDEALTKFPKIHDLQNELKTNFSLNDEQRTAKEEDLRTAESQAQSYMQLTNETVSMMKLFTKSLSASFTMPEIVDRVAAMLDYTLDILVGPKSTNLKVDDMKKFRFEPRTLLSEFIDIYLNLSVSEDFVRAVAQDGRSYKPTNFEAALRILTRYNLKSPDEISAWDDLRLRFIRAKEEDDQEEDDLGEIPDEFLDPLLANLMKDPVLLPRSQQVLDRSTIRSHLLSDPNDPFNRQPLKIEEVIELPELKARITQWKQEAKAKAKAAKLNSRDSMDISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P667</accession>
    <name>A0A0B1P667_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tpr repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001809">
        <property type="protein sequence ID" value="KHJ32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P667"/>
    <dbReference type="STRING" id="52586.A0A0B1P667"/>
    <dbReference type="HOGENOM" id="CLU_040446_0_0_1"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="266"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="43160" checksum="B80DC1B1644B6473" modified="2015-03-04" version="1">MKDTKEITSQDEFLPALPPAMVPFHNKSANEILADLNKMPLFMTTIEENDDVEALRALAYEGTPLEVASGFKENGNECFSKKKWKDAKIFYGKAIDVLLVEQRKRQGDNIESSLASSQIEREKQQETLLLEICLVNRAACHLELQNYRSTIQDCGKALQTNPRNIKAYYRSSKALLALGRVTEAKDACECGLSIDTDNKSLCSLITAITQQSSNIAKKEKERCERVERERIEAKTLKAALAARDIIICKTGQSLDMDGERIKLVPDPLDPSSTLSFPTLFLYPISLQSDFIREFNEKECISDHLEYILPLPWDSECIYTPTSVDCYVEGRTGGLSKIGKNVPLLRVLVSGKIEIIDELIKIFVVPKANAADWIKEFKSKKSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6A2</accession>
    <name>A0A0B1P6A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glucose-inducible sam-dependent methyltransferase rrg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002056">
        <property type="protein sequence ID" value="KHJ32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6A2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6A2"/>
    <dbReference type="HOGENOM" id="CLU_049351_1_1_1"/>
    <dbReference type="OMA" id="ARIMACL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="38229" checksum="29D0E5C7962D775B" modified="2015-03-04" version="1">MMEVILNLHDKPDFNQIVVALESRNHGVNNLCMGNNTALTSINDFSMRIIKSDLGWLSEIEKDIVYDMASKCIAEKCGRTAMPEMRRKWTIPATDLHPTIEILLREPSLTGDNLGLKTWATSFSVSKKIGQVGRDYFLHLLSPINSLKNCIHLNTLQSKIRVLELGSGTGLLGIVAAAVWGVPVLSTDLEDVQENLCYNIQLNYDAISRVSGGSVSSKVLDWRIPEKAFSELREFELIMATDPLYDEFHPLAFARTVNLFLKKNSDSRLLVAIPLRDKYTFQLSQDLKRQLLLRQFQIVSVDLELSQDNDWAGSRNNSDSFHIETTIWRRSEVDTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6I8</accession>
    <name>A0A0B1P6I8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g1043</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001178">
        <property type="protein sequence ID" value="KHJ33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6I8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6I8"/>
    <dbReference type="HOGENOM" id="CLU_006714_0_1_1"/>
    <dbReference type="OMA" id="EDNEPHT"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="538"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="773" mass="84704" checksum="ED8000206727CDF7" modified="2015-03-04" version="1">MPFLNQGPRTLYDKVFQDHVVDERLDGTCLLYINRHLVHEVTSPQAFEGLRNAGRKVRRPDCTLATTDHNIPTTSRKNLKNIASFVEQEDSRLQCITLEKNVKEFGITYFGLKDKRQGIVHIIGPEQGFTLPGSTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLILRRSKNMRIQVDGPLNPGVTSKDVILHTIGKIGTAGGTGMVIEFCGTTIESLSMEARMSICNMSIEAGARAGMIAPDEITFEYLRNRPLAPKFGSDEWNNAIKYWRSLKSDPNAKYDVNVFIDAKDVAPTVTWGTSPEDAIPITSCVPDPESFSTEEKRAAGRRMLEYMDLKPGTRLEDVLIDKVFIGSCTNGRIEDLRAAAAIVKGRKVAPNVKRAMIVPGSGLVKERAEAEALAEIFIDAGFEWREAGCSMCLGMNPDVLQPGERCASTSNRNFEGRQGAGGRTHLVSPATAAACAITGKLTDVRKLVDQSNLPIKQSSPLKTTTYIEKSKESCDDNDCSSPDQDLKPDSCNDTISTQSKVSELPKFNILKGYAAYLDRVNVDTDAIIPKQFLKTIKRTGLGTALFHSLRYNLDGSENSDFILNKEPYRQAKILVAGSNFGCGSSREHAPWALHDFGIDCIIAPSFADIFFNNTLKNGMLPIAITNSSDYDAVVAESIAGNEIEIDLPNQTIKSSTGLRICSFEIEEFSKYCLVNGLDDIGLTLKNEEKISTFEKQMTLKMPWLDGSGYLKRGVGGMLAATAAEIPKTNRGEEIQEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W7</accession>
    <name>A0A0B1P6W7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gtp-binding protein rab2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000876">
        <property type="protein sequence ID" value="KHJ34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W7"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="ANGVMQY"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001537">
        <property type="entry name" value="Secretion related GTPase SrgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="239" mass="26478" checksum="46274D62B5751392" modified="2015-03-04" version="1">MSSWDYIAKLVCIGDSGTGKSSLTIRLCEGRFSPHHDVTIGVEFGSRILPVGPPNSLDKSSRMNIQDTSNTNSTEQRYMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDITRRHTFLHVMDWLNDLRQIAETDIVVVLVGNKCDLSTEGDNKREVEKEEAMEWAQKNGVLEYIETSAKSGDGVEMAFARVAERIYMNIEAGKYDLNDRRSGVKGPQSKGNKGNVQLTATSKGTSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z3</accession>
    <name>A0A0B1P6Z3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000859">
        <property type="protein sequence ID" value="KHJ34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Z3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Z3"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_2_1"/>
    <dbReference type="OMA" id="TMTKGSP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="66" mass="7699" checksum="4D254FF05734F9CB" modified="2015-03-04" version="1">MVKLGTNNEKRLMIDIMAIRQSYERRELSEIRWINGNDNPDDTMTKGSPIKALEQMLNLIPLKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z6</accession>
    <name>A0A0B1P6Z6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002081">
        <property type="protein sequence ID" value="KHJ32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P6Z6"/>
    <dbReference type="HOGENOM" id="CLU_000310_0_1_1"/>
    <dbReference type="OMA" id="NSHLTLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="1">
        <location>
            <begin position="609"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1304" mass="149504" checksum="8EDB140ABA1C3C27" modified="2015-03-04" version="1">MHCMLPGNPIPVTQAICTGFWDGKQFITYITGTAIVILTTPQILWQVIYDDSEEQLEAISFDEITGKIVVCARYQIRIYKPYGQGREIEENLKWSLQESFNLDETSITTYSVKTLSWGSSEELLVGSSYLELFSTTNNATRIWRKRLANNVRFAELSYDSAFIASSGPYDRFVKIWRRQSFESDETRFDFSYLSHPAAVTNIYWRKPYHIDQSIINVLYTTCADQIIRIWVASDIHSHCVKHLNFWNQIDLSESLKPRTLSKLSNIRFSFIIDGRDFLQATELAVQSKKINNNPENLALSHLVEVANHSPEICVVLDDLGHMSAWGIENISSKTVMEARIFNVAHVNDLSIGLPSVSESQSRQVRFYSYSNRSGNGLHILLHHFDGRIEVFESDLASLFDPSPRPNRLVSKTVLTGHSSRITNILRGGNGHEFVSWTDRNEVILWKLANSGACESINRKSVIMQEEKIHEVCVLEKYDMVVIATQSKISLWDTRSLEAILYAESTFSLDGKLSCMLALPYDEKIGVIFISTISSKMNGILWGIKRLDCKSTLKKAEYDYEIRKFCTFNIDSPDGPSTFHPLDTFGKLSETTGYPKNFNSNVAISHTKSGVLQLWSANINLNLNKIDWIKTSSLCTCITQPSIVSGNYLRKIALVNSKKTQLTIWNLLDACIEHVQDYDFYDTIQGLDWISTPDSKLILAVRFLYRVTILAQIKYDFLDRSPSWITIRNFSVREITPHPIGISMWMCNGDYIIGTGNQILTANKAVVTTDLAIDHQLLPYKSEWDIFEIMTQLNKSIPAYHPQFLIQCVNADKFEFVEQVILELCKILKYYIEGDPIDDFLGIDIESFYIEPNYKPITYTTGQSNFSILSHHFDERETITEAHVSYVTDKLAKIFLPFLSRLEQLNLIDTINCVSNILPIKKSLDENAIKYLFSFLFQNIRCRVGSPIMGWREINWAYHSKCQDTLIDMVSRQYRGKVSWEKAQESGICMWIKDRTKLLSFFEDIARNEYNKTDLKNPIDCSLFYLALRKKSVLQGLWRIATWNREQSATSRLLANNFQEKKWRTAAMKNAYVLLGKHRYQYAAAFFLLADCLSDSINVILTQLKDLQLAIAIARVYEGDDSAALVDLLEKKMLPLASQKGDRWMASWAYYILQKNDLGLKVLIFPSHNLSDLSWAINFEAKSYLINDSSITAFYVQLRDTTTIPHEIALMEWNLVLQNARLYYRMGCPLLALHLIRNWRFHHPEQPAIKNVEGIRLKSSFQRNSLMTDVSSKTASFGIKACSHQPSSSIFQEPESTSLLDNFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P761</accession>
    <name>A0A0B1P761_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transcription initiation factor tfiid subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001589">
        <property type="protein sequence ID" value="KHJ33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P761"/>
    <dbReference type="STRING" id="52586.A0A0B1P761"/>
    <dbReference type="HOGENOM" id="CLU_035243_2_1_1"/>
    <dbReference type="OMA" id="RRIVNQT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="172"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="318" mass="35813" checksum="DCE4BE860AB77502" modified="2015-03-04" version="1">MASPPNNQSFSTASSSNTIFHQSIPHMSKRRQLENPPSAPANKRRKASMAPLNFSSIAHPLRQTSFPSERTSQSPLGHSRSPSVDRMSAVSGSFSAYKKKKSRIVKSKDLENTLGSGVYPAASDANKVTSRKPISDTNLEEEEEESSQELGGNSTETSKEERLKEERRRHLLTRAFNKEQWQRYEAWRSSKLSDSVVRRIVNQTLSQSAPQQVILAVRSVAKVFAGDMIERARKVQTEWLEISGENPGLPFLKVEDSSIPKQKEKRRGPLMPDHLREAFRRHIMTDPALVGQLGLWQHQQQSGVERFGARIGGKRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A7</accession>
    <name>A0A0B1P7A7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001562">
        <property type="protein sequence ID" value="KHJ33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A7"/>
    <dbReference type="HOGENOM" id="CLU_169175_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061935" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="81" mass="8697" checksum="A030DB4F938297BF" modified="2015-03-04" version="1">MLFKTLLAFFPVFHMIAIHGAVIKAIRDEGGNLPTFRVDASSSGGSQRNGGQRDPIQTDKKNHRSVNVDICGKTSGDAPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B1</accession>
    <name>A0A0B1P7B1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001018">
        <property type="protein sequence ID" value="KHJ34153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B1"/>
    <dbReference type="HOGENOM" id="CLU_565240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="483" mass="55978" checksum="8B520D2127432280" modified="2015-03-04" version="1">MTVSRVVSGLSDDALKVKAIERGVASSSNLEESFRIIRDQRENLKSKWFNRILKALNQVTEVLQDFAYRYNNPNELHQIIMLACQSTPQQSYITPILNQNALPSAARQLTSRFFSMPNSQGMNEYPREVKFLNIDDNNPWKQQADYTPQVQKTEVRYQGPEYRGENPWKGESSWAMRWHNRDEQTVPSQNADRNGKGREDMITPQSFHSSHLMVNGEIEYRNNKHRQKKEVFERRETQPKSFIQSSDQLTANEVEIEQRKKHRYEAAGLPQPYIEERTMPRNNGVEEMSVEELIALDKITGQNENKVNAVDESLDEYLLDEPLEVETSKTSFPRNTTTTEKTKERSPTESEILLSAHVIDRDNTKRPRTHHDILNDEDIEPLPKVSSIQDEFTQFRGRAKLGRRQIEPLINARINEGPLDYMKILGRTKVEVSLTDLAQMSPAARKHWKHGILRVNDKRSRRKRHQAEISEVASNSLSHPNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7F9</accession>
    <name>A0A0B1P7F9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001539">
        <property type="protein sequence ID" value="KHJ33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7F9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7F9"/>
    <dbReference type="HOGENOM" id="CLU_008206_0_0_1"/>
    <dbReference type="OMA" id="TMEKDDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056687">
        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="4">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="3">
        <location>
            <begin position="472"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="764" mass="84376" checksum="B41B302C42C9C19D" modified="2015-03-04" version="1">MSSMNAVLSPPMILDSVTSSMNLSKRKRENSVSSSECEAPPEIPLAESQALIKDFIQILEADDTTPSILTRSIPELPRLNCSNSKRQKADEAGEPPTSIMGRLSSNTYTNIDEVLADIDAAVNEIVDKLDLSNSVGQNQCSTTSRAPSELSIKIMEFRKRAHDLVKREKSSWERRRKTNANGTSHDYVRFSGQDDHSQLSSSINDNKLVLTIFGNAPTPKQLFSGFQLPTRINPNEEGVVIPIREMALPNGISTTRIITTHPSSVIDSRKRPQTMGEIFPTPPNVTPSIPPKPFFKATTKSSTVGWYRPSNFKSSTKSLSYFNQGISSGQWIDYSKTQSSIGGYMNRNNALDLDIDRGISIDSEASESEAERLEALFRRAYSSFAPTKDNAAAIAPTGCLDQMWWNEIGKKKFNNFVQTSSIETDEAIPSLSESSSTNDLLTFEKDLEELEKNLIDPDLCALQSEEDKAIHEKEIDEVLKEISQLLETLASYQQIRHLSSNLSNRPTTISSTLDQNPLGAIPQPNESEISIYEILRSQLSLMVSSLPPYAVAKLNSDRLADLSISTKIEVRLNDFKGVMEEEESSARHKIPSTVTSAVPSPRQSNQSIHRSSNSGNNGSSPHYGNQLASPQSRGLTAQYYSSAQTPIRPTTQYYNSIQTPLRPSPSNTQRPTATTTASYQAQRTSTTGPFRTNTYGTSSFPHQPTRPTQQQFTPSGQHIPYSQTPIGQGYLRVQGQSHHLQHGPQSVAQTAMTNNYSSVMNVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7S0</accession>
    <name>A0A0B1P7S0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="JNVN01000722">
        <property type="protein sequence ID" value="KHJ34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7S0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7S0"/>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="OMA" id="IVRFGCE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="326" mass="35970" checksum="A164B24CCA623B6F" modified="2015-03-04" version="1">MSSSLDQLKASGTTIVCDSGDFESIGKYKPQDATTNPSLILAATKKPGYSKLIDIAIAYGKEKGGSINEKVDATLDRLLVEFGKEILNVVPGRVSTEVDAAFSFSIQGSVEKALHIIKLYESIGIDKSRILIKIASTWEGIQAARILQRDHAINVNLTLMFSQVQAIAAAEADTFLISPFVGRILDWYKAKTGKTYSKEEDPGVQSVKEIFNYYKKFGYSTIVMGASFRNVGEITELAGCDYLTISPNLLEILSTSKEIVTKKLDVSSASALQIEKKSYINDEPSFRFDFNEDQMAVEKLREGISKFAADAIELKDILRKKIESEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7T2</accession>
    <name>A0A0B1P7T2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000717">
        <property type="protein sequence ID" value="KHJ34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7T2"/>
    <dbReference type="HOGENOM" id="CLU_1168208_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="29699" checksum="ABBF815BA89980D8" modified="2015-03-04" version="1">MITATTWIRRGVAAPLPSKCVFDEVEYQRIAELTRLQLDDANEDMMDTLESVPDNLNPKLDDKNESDSDISEHMDVSNEEDELKKYDLENYDDEQEMEQDNSDKSLSMFGNLRSLIYYESNADDPYITLPENEEEDEERQELQILPTDNLIIAAKVEDEVANLEIYVYEDEADNLYVHNDIMLPAIPICLEWLEFPVGKTDSENKSGTNFVAVGTLDPDIEIWDLDMIDCMYPNAILGQERNENISGPNKKKKKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P817</accession>
    <name>A0A0B1P817_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000894">
        <property type="protein sequence ID" value="KHJ34398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P817"/>
    <dbReference type="HOGENOM" id="CLU_1518972_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="177" mass="20079" checksum="3D73DE868BF3CDEE" modified="2015-03-04" version="1">METSKSGEEKREIAKLSYQELVEKTGLKELISAKQISNGRVKIYFTGQGTKEMMEKHTDWTTKLAPTAQVSNPTYQIFVHDISLSFDPGIAEYIKELQRANEIYLQGIRIQKAVWVKKKLDPKKIAGSLILWLEQAEVAEKAITKEIMWKCDLNTMEIFRSGFGPCSASTAKDMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P820</accession>
    <name>A0A0B1P820_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000891">
        <property type="protein sequence ID" value="KHJ34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P820"/>
    <dbReference type="SMR" id="A0A0B1P820"/>
    <dbReference type="HOGENOM" id="CLU_1994305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="14106" checksum="AC6FFE85CAC39135" modified="2015-03-04" version="1">MAPLPVLTSAADLISRIEAASPKNRSEILTELYNSGKQYLGLSLDLKTKISELTEQLSELTKQLSDHKLVEERLRMEIKDLNSAAIQNLKSTAVLEYKLSESDKKVKRKLACWNRNGLSQFFTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P836</accession>
    <name>A0A0B1P836_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cp2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000654">
        <property type="protein sequence ID" value="KHJ34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P836"/>
    <dbReference type="STRING" id="52586.A0A0B1P836"/>
    <dbReference type="HOGENOM" id="CLU_012196_1_0_1"/>
    <dbReference type="OMA" id="NQPPGYY"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="245"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="789" mass="87653" checksum="250ECB5CC62B85A2" modified="2015-03-04" version="1">MFRNRTSSLKPGMEFIANFRQSFPEVSTIMSPDPSSAGTSLGSVLIEAPLLERHHSFGSDSIKDLESTPRAQHEPWRFTPSLLDPNSFGFSPFPSQPPGYYSPTPGSSNSQWQGQAGDLQTPGVNMSIGLHTPLSLPASAESLPSGPLLDMAAFNSQLQPQFSNYNPFGHQNSDQQHQSNSFTPSSFLQHQDNRYDCIEHHGSPMDDDVCLQSMEVNLPNHQPVIPYHLSPFNMLGVASIPSSTENFRFHVTLNAPTAMIKHPDEIPVTYLNKCQAYTFSIIDKAPILPLPVGTRYRTFVRISFEDEQQRQRPATCWQLWKEGRGTNEAHQRGGKLQAVEFVESNQQSENDENRTRVELDTASFDGFSVIWTPGSSGLAECTLAVRFNFLSTDFSHSKGVKGIPVRLCAKTQTLSTGSPHADSETSEVAYCKVKLFRDHGAERKLANDVAHVKKTIEKLNQQIQQSESGMKDFGKRKRTGSSSIKVHPNQRPVKVHKHKRTWSMSSASSSGGRIPVEEDLYVKLKNMKDMFTSTRPISILYLRGSEQDDPDLYPVVLAGEPLDLTKVDPRTNALWQQRNSDRGSASGGASSLISLSPSGGSYHSQVLSSSAQPSQHGNWADFSQITPNDLHSSQHLSSSPDQLTKIAKTDETGNLSGWIEALGVDPSYKAPVEPASKAIACFYIALEDKNHPEKHKYHRAIYLTQRTLKDFKNGIALKWGFDPARIIRILRILERGLQVEVDDDIILGLAEGQDLTMEIVPVEDTVDCKNLNLITNGSYSENFELRIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8F5</accession>
    <name>A0A0B1P8F5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endothelin-converting enzyme 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001566">
        <property type="protein sequence ID" value="KHJ33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8F5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8F5"/>
    <dbReference type="HOGENOM" id="CLU_065920_2_2_1"/>
    <dbReference type="OMA" id="WDINVEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="14338" checksum="B9763639498FDAE2" modified="2015-03-04" version="1">MKKKYSSLETEWSVMDVRELDLEDESVDFAIDKGTLDAFLHGSLWDPPEDVAKNVGLYVDQIMRVLKLGGKWLYITYRQPHFIKPFLYRINSTTDVEVLDDVNGAGCFSYFGYIISKEGNIDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8G3</accession>
    <name>A0A0B1P8G3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bet3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001715">
        <property type="protein sequence ID" value="KHJ32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8G3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8G3"/>
    <dbReference type="HOGENOM" id="CLU_1959341_0_0_1"/>
    <dbReference type="OMA" id="HDSQITW"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="13643" checksum="CECA6667E8DA441E" modified="2015-03-04" version="1">MSNDALLPPSNFSDPTATYLNLSCLDLLMIELVPLAYRLANEIDATATTTMNTELEGRAIKRQNIHGGEGNLGIDGNLGVSRVKANSTIIAESKKMEEDEERDAVFFRLEALGYRVGQGLVESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8J8</accession>
    <name>A0A0B1P8J8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001300">
        <property type="protein sequence ID" value="KHJ33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8J8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8J8"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="OMA" id="QSYTFFW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="501" mass="56355" checksum="A0D65C9CF0E7E420" modified="2015-03-04" version="1">MGSNSSKPASNEKLIIERLRSLEMKDEEYFNVNEKSVPGISKMTFQTPWKPLSVSEIKFWEHQLLQDPKNRLALSALSKADPKAVLTSRSAVIRDQHVFNTVIPLEGAPITNQKSSGRCWLFASTNVFRVALMKRHNLDKFELSQAYLFFYDKLEKSNYFLQQVLDTVHEPLDQRLMQTLLNQPVSDGGQWDMVVNLVEKYGLVPHVLYPDSFNATSSSSIDDLITTKLRENALRLRSFASSGTKSIEEISSIKDRMVREIHLILILTLGPPPAPSTEFVWSYLDKNGIAHELRKTPIAFASELESQKSIRITNSAVQSMISLVNDPRNEYNTLLTVDRLGNIVGGRSITYINVSISTLKNACIKMLQAGLPIFFGSDVGKYSNSSTGIMDDSLIDYELGFNVKLSMTKAERLMTGESAMTHAMVLTAVHIEDGKSVRWRVQNSWGSGAGVDGWFVMSDKWMDEFVYQAVVEPRFISQEVKDVLKTKPKVLPLWDPMGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P960</accession>
    <name>A0A0B1P960_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001181">
        <property type="protein sequence ID" value="KHJ33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P960"/>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3746"/>
            <end position="4082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="749"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1192"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1550"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2355"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2675"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2868"/>
            <end position="2955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3027"/>
            <end position="3057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1550"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2374"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2407"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2458"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2477"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2493"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2510"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2685"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2868"/>
            <end position="2905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2920"/>
            <end position="2931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2941"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3027"/>
            <end position="3046"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="4082" mass="456150" checksum="07963936B16A8FBD" modified="2015-03-04" version="1">MVRITKVMQPKHAESLTPWTKNFCDRACSIPLTELASFLSTFPTRWPFPRGDLHHWIPLLNRFDTILEQFCKVYKLDEGPQLVEFGNLLLDAERLKSDSEPHQDADRELVESVLNFSRILIQNCGNRTVYASSSHLDNLLNTTSLSLLESTLYLGSELAQRYQSAIKRMSVTTRHLHNSLLQSHYNIPLDKVIKLALPFSRIVKNSTENSHQNSSLNPGLKGKEKTPQSLLTSSPKNPTTTICANDIMTMVRDGISVKRTSKTTYSGTEDASHQTETCWSDWGDVKLIFYPKLHSDVEAATDLSSNNIPAITPSTPSPVRRSSNLGPRGQRSTKISSSESPLATSPCSKAHQSTDETLRPSYKIIEIPQSTLLSTDIHSILRENITGLSKELKYELLVKLRIAYALTSCLETRRQIVAIRILAIINLAYIYPDSLFQDLVMKHEIEQPRRLQLVHQLAELVHPPTDGEIAVPRKLQALAFVALEVLQGHQSKVSEVSAALNTNVNHGVLLYVVRKAVAEMDRVDSGDHDTINDEWRDCLFSLLSSISLISRTAIDLVAAGLIQILVDILNQRTTIAERYYPMVLTFLDNVMYSARDGFQTLVEADGLNAISNLIIYQVRTAAENVSAGKGTPQEFRSAVVDYEIPYYQQQTIKWLFKFIHHLMSATGGFGGNFDRLLRNLIDSSQLLASLRQIIGNANCYGSIVWTNAVLILNDFINNEPTSYVVIAEAGLSKVFLEAVTGRMITASDESKVEEIPTESTNSGDATTSSSPHIEDDSDEETPHVERLSLTMLKATRKGPLAKGILPTSETISIVPQAFNAICLNTAGMKMFQASNALQSFFEIFESPEHVKCMDTHKELPATLGSSFDELARHHPGLKNSIIIAIVNMVARVEYLCSSRARENMLGAKLWSMDNAGKIIVANSDAMEPSNDPKINQEASDVTTDVEMHDIDADPDINLNNTSNTNEMTPGALQTNMTPYICATINFLSSILGNTSIRTGFCVMGGIENVLSLSQSPSLEYDFWDSTFSLTIHQVIAMLAESKPHLTVPSLLKRALKAVNELKPLTSYDGNPAFFSPFVYPQLQASTNIETLSKGTEFAKALVSIHSLVSTIMTCFQSPPYNHRGSSNIFHQINVADYCIQLVQSLGPLLASSLREVIKLRNIVPDNWKDATSFESPLSSLLSNFSITGARLSQTGPSDNSHSINPPDPSNTAEKPTTSINTNSFEINPGSISKVEMESAAFKNYITLKFLLKKLPRIISPFLQTLGKVLLAKRNLDSFQKQYHFAVANALADSILNQMTIEENIEENPNLADIYTYWLGMIAVLHELLLEYSNQNERHSHTITLVLQAFKEHGGFEKLNQMLENFANTICTQGGTLKTIQESTLRVELATSGIISLLSLYGNLVNGINFTEAPQTTALVTRTERDRRGLEYFSAPQFLVEMRMIILPTVRRLWSSELTEKGSSQISERLIHVIRMIVLADSENIPINRADRLTNQAKISHKVFKTNQDSSTTLLDQGYPESLVNEALYRCNNNIAFAQEYCRELKGIEDSNRRNPIPEKDVEAPAEAPAEARPELDVTESTSSNSLLLVDHPMDQEIISGAVDSFNEVEAPFPSDELANFDQLLTSLVPVLGSGPTIITGPTDTTSPQESARENIKSTSVTINDLNKERTLISDNLIDKCLDTINAHGEVTFDISDLIMTVVSKSSDPVILQKVIGETLVVALMSFVGEDDFSKSGKKIAAYAHLLALLLRDKSFYSATVPELKQNLDSLLMFIKLSPKHVPEEPSPWIAHILLIVEILLKEDEKPQKIKWNPPVDENSVIDVPEIEAPELSISLEYRSILLENILDILPRIGKDEPLALSVLRVLVIITRNREIAQTMAEKKNIQRLFVMIKQLAGVSSARIHSPLMLILRHIIEDHDTVKQIMKSEIKTSLEPIRSQRNVDEKTYVRLLAHNALRNPELFVKVTEETVKLNRWSYPSSDSPSRHYNIVLKQASIDAPPQISPIDTDLPTVQATEDLSIQGSSTCKETSSTGYQESTKLAQEKKASFAESSDGVIHFLLCELMNYRDVEEKEHAGASPYISEKGNLNSNGDITMGGGTPILPSISIDNKNTNLVSKKEFKAEDNPIYIYRCFILQCLTELLSSYNRTKIDFINFKRSSQPQAVTSTKPRSSVINYLLYDLVPTGTLEHAENTYLRKKLVTSSWANCVLAALLCKTNEQPLDKSRDPYETEVEPDILFVRRFVLENILKAYKDASSSVEPLDIKYSRLLGLAELMTHIIHGKENIAIIDQTNLSASQKQIRRIMFEKGFISALTSSIAEIDLNFPGAKRAVKYILRPLKTLTQTAIALSDLSLIKSTPDQGDEDEIESAKSISESEDEREETPDLFRNSTLGMFEHGTEDSESQSGDNEDEDMEGTYDEYVDEMDYDDGDMDENDEDDISDEDEIEGIGSIEGLSGDHQVEVEVFMNDHDDDHDLSPDNEDDSGSGDDDDDDDHHVEIIEELEDIQHQMDDDDELADEWESDGQDDDDDDRDGEEYEGSYEDQEEEGATIDLGAMSHLVRALEDDPAALEILGRMAEGEENEAGHVIADYAEEDEEDDDENDDEDEDDIFENQHAIDSASGNVTFGWPPEIRTVLPARIRSRSGFSPFPSFPGVSRDPLGRHNISYRPYRPGISLSRSVDDGTNPLLQRNNSDSRTASSLPPLMGTWIPGIRGSSNNELLDIGFATQGGNTTEGLTTTQFLEDVIRTLPLPGHLGRHGQALQFHITTSGPSSRHIPPELEALFGSRHTRFEERRNAPEPVSVSHFTAQSTVSRWAEEAKILFGSSWVDRAADLAGTLLSILVPPAIEADKAQKAAQLERTRLEKLAADKKAEEERLEKEAKANEEKLAEEKKEQEELQAAERPDEGNVTEVTQVDNADFEPANENQEAAPESMEGVETELPESNNSTQSASVESRERVVTVIRGNSFDITDLGIDADFLSELPEEIREEVIMSAVAERRSHAAATGAQPSEIDQEFLNALPDDIRDEIIQQERRDRRRREREERSRQNMVANGGPSVGDMDAATILATLDPTFRNQVLMEQDEATLALLPPEIADQARNTTSDQDRASIRDFANSLRLPNTTVIRRQTGYIPPLPELRDSANHRSTRRSTVQILDKSGVATLLRLMFISQHGTLRSTFNAVLQNISMNKINRQEVLGTILYILQDGSIDMAAIERSFVYLSVKAKQSKDAQIKTPQPIKKSLLGSSSIILTNFEASPLMVVSQCLTTLVFLNQLNQHISAYFLTEHETPGGLKRSLSRKGKGKENKSSKYAINTLLSLLDRDLIMESSSIMESLSTLLNMITLPLQVLQRKNKDTEGAIIEPAQSNMDIVASIASPETSNTNNEQSLDMHVRPDNSDLPPSTQISSTQVVTTPAEQSSANLADVPIAKAEDMSKHLEKKQRAISQPVIPDNNLKLVINIFVARECSSKTFRETLSTIKNLSAIPDAKAVFGRELVNKAQFLGNIILQELEDLLLHIQKANSGTEIQAIALAKISPGGSDQNKLLRVLTALDHLFDPKREKKDKNDDSQPENNSTQLIAKDLLSSLYENPTFGRMWQMLSACLNAIRQRENMLNVATILLPLIEALMVVCKNTTKDTSQSNFHQGKELALTSPPPDARIGSLFFTFTEEHRKILNELVRHTPKLMSGTFSLLVKNPKVLEFDNKRNYFNRSIHAKASNSRETYPTLQLSVRRDLVFHDSFKSLYFQSGDQMKYGKLSIRFHGEEGVDAGGVTREWFQVLSRQMFDPGYALFIPVSSDRTTFHPNQLSSVNEEHLMFFKFIGRIIGKALYEGRVLDCHFSRAVYKRILGKSVSLKDMESLDPDYYKSLIWMLENDITDIMTETFSVDSDKFGVNETIDFIPNGRNINVTEENKHEYVRLMVEWRLTGSVKEQLDEFLKGFHDIVPADLVSIFNEQELELLISGLPEIDVDDWKGNTEYHNYTASSPQIQWYWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELEGMNGFSRFNIHRDYGNKNRLPSSHTCFNQLDIPEYESYEILRQQLLTAITAGSEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P995</accession>
    <name>A0A0B1P995_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gtp-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P995"/>
    <dbReference type="STRING" id="52586.A0A0B1P995"/>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_1"/>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="45395" checksum="945295851A468BE5" modified="2015-03-04" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDASSKVGPFTTIDPQRAIGYLQIDCACKRYDLSDRCKPNYGSCVDGRRSVPIELLDVAGLVPGAHEGRGLGNKFLDDLRHADALIHVVDVSGTTDAEGKSTRGYDPSSDINWLRSEIVQWILGNLIKRWESVKRRHVAVKSSAVETLQSQFSGYGSTTPLIVRTLERISIKEPLEQWTPDIITKVVESFIDEKFPTVIALNKIDHPDAGKNISKIMKIHDPKTIVLCSAIMEVFLRKLNKQGYVRYTEGSEYVQTKEDLIEEGDPNGGNLKDLDEKLQARVENIKDMVLYRFGSTGVVQALSRAAELLGLVPVFPVRNTTTFSSGASSSSAVFRDCVLVKRGTTVAEVARKIIGDAPLAYIEGPGSIRVAEDKPVSAGNNDILAFRIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A9</accession>
    <name>A0A0B1P9A9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A9"/>
    <dbReference type="HOGENOM" id="CLU_112609_0_0_1"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="154" mass="16626" checksum="6A1F11F1BD46864B" modified="2015-03-04" version="1">MDDWDSVTKIGSKTRGGGVARETVVRGKSALNAAQRNGAVLATEKKFTSGNLSSKPGVEGQHLTKVDRSDDIVKPTTVGKEVGSAISERRQKMEPKMTQKDLATKCNTTQSIIADFERGTAIPDQKLLMNMEKVLGIKLRGSDIGAPRFGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9H8</accession>
    <name>A0A0B1P9H8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0302</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9H8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9H8"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="71"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="587"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="783" mass="85710" checksum="771674947F690B49" modified="2015-03-04" version="1">MMVLRRLHGVGQLRASAMLRTRGMATIGSSPLDKKVRQNNKEANNFINYKAMAENLAIVRSRLNRPLSYAEKIIYSHLDDPHGQEIERGVSYLKLRPERVACQDVTAQMAILQFMSAGMPSVANPTTVHCDHLIVAQSGGEKDLVTAENVNKEVFDFLSSSCAKYNIGFWRPGSGIIHQILLENYAFPGGLLIGTDSHTPNAGGLGMCAIGVGGADAVDVMANLPWELKAPKVIGIKLTGQLSGWTSPKDVILKVADILTVKGGTGAIVEYFGPGVETISATGMGTICNMGAEIGATTSVFPFNDRMYEYLAATNRSEIGDFSRIYAKELRADENAEYDQFIEINLSELEPHINGPFTPDLATPISKFSDAVKKNNWPEDLKVGLIGSCTNSSYEDMSRAASVARSALDHGIKAKALFTVTPGSEQIRATIERDGQLQTFEEFGGMVLANACGPCIGQWDRRDVQKGTPNSIISSYNRNFTGRNDANPATHSFVASPELVVAMTIGGSLHFNPLKDKIKDKDGNEFLLSPPSGDGLPVRGYDPGKETYQAPPVSGESITVQVSPTSDRLQVLEPFKPREWKDVLDIPILLKAKGKTTTDHISMAGPWLKYRGHLDNISNNMLIGAVNEMNGEVNKVKNFITGEIDSVPATARDYKKRGIPWVVIGDWNYGEGSSREHAALEPRHLGGLAIITKSFARIHETNLKKQGMLPLTFINPEDYDKIKSDDKIDLMITEFCVGKPITLRVHPKDGKTFDIKLAHTFNERQIEWFKNGSALNTMAKSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9P8</accession>
    <name>A0A0B1P9P8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5262</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="JNVN01001068">
        <property type="protein sequence ID" value="KHJ34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9P8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9P8"/>
    <dbReference type="HOGENOM" id="CLU_054856_0_0_1"/>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="251" mass="27310" checksum="616611B61B08C7F2" modified="2015-03-04" version="1">MSPPAIIAPSILSADFADLGAECRKMMDCGSSWLHIDIMDGHFVPNITFGAPVVTKIRSHVPKPQMKHGVGTFDCHMMIAEPKKWVKEFHKAGCDLYCFHYEAAINSTAAESPEASSNEKTSPRDLIRYIHECGLLAGIAIKPDTPVDVLWEILESKDVREVPDMVLVMTVYPGFGGQKFMASELPKVQELRKRYPNLNIEVDGGLGPATIDQAAQAGANVIVAGSAVFGAKDPGEVIAKLKTVVESYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U2</accession>
    <name>A0A0B1P9U2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001439">
        <property type="protein sequence ID" value="KHJ33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9U2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9U2"/>
    <dbReference type="HOGENOM" id="CLU_018190_3_0_1"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="58798" checksum="D7549FD1206B28E1" modified="2015-03-04" version="1">MATTDTKIAVTDLSAECQKDLSTLQRRNVVTAYLNPPRNELAKLQPFTEAISQKKYKHAAVVHSLPRTSCLSHESQMAPSFLGFRNLMVLVLIVGNLRLMMENFKKYGVLICVQCHNYRSQDILLGVALLLVIPCHLFLAYVVELIAAQQARSSLQLKKDRDGTATPGGSYIASEKEKREFNNTWQIIAWIHGINASLCLLITSVVVYFFIHHPLIGTLIEVHALIVWLKTASYALTNRDLRDAYLHPSKRGQDAMPELYKKCLYPSNITLSNLTYFWWAPTLVYQPVYPRTPKIRWIFVAKRLAEVFSLNAFMWIASAQYAAPVLRNSLDKIATLDLISILERLMKLSTISLVIWLAGFFALFQSFLNALAEIMRFGDREFYKDWWNSPSVGVYWRTWNKPVYHFMKRHIYMPLISQQGGAKKANIIVFLFSAVLHELLVGIPTHNIIGVAFMGMMLQLPLVAITAPLEKIKGINGKILGNCIFWISFTLIGQPLAALLYFFAWEAKYGSASRPAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Y1</accession>
    <name>A0A0B1P9Y1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001413">
        <property type="protein sequence ID" value="KHJ33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Y1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Y1"/>
    <dbReference type="HOGENOM" id="CLU_012596_2_0_1"/>
    <dbReference type="OMA" id="PTMWWLA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="561" mass="61824" checksum="7B1BFCB5BC1A8D9F" modified="2015-03-04" version="1">MSDADASSLLIASQKSNLIPQSVPARSKFKMQKSAIIRYTALFSAVFSSLCAGSISTFSLYGHLLQTRLKYTQTQVNTVALAAQITLCLSVSFIGYLCDRVQPAFISLSSAITFGLGYSVAAFTYKYGANSVYENIQPSALSVWIMVIAFVMIGLATTMMYLSTITTCAKNFRNDKHRGLALASPIAAFGLSGFWQSQIGSKLFIEHSLNGKKGDVDVFKYFIFLAFLLTVAGTVGFFLLRIVDENNLIDEATEQQERTRLLGSNEPSFNSRINYNSRVDAPNNDEMGNRSKKLSKEEMSRYLNLKTATFVRDPTMWFFAVGFLLVSGTGDAFITNMGTVIGTLDFSSQDPNKLSTIVATQVSIVSLSSTAARLIFGSLTDIFAPAPSLNFDHYSVHSSTHHKFCPSNFSISRNVFLIGSALLLSAGQVVLAAGFAQNHMNRFWIVSTFIGFGYGAVYTLSPLIVSIVWGVENFGTNWGIITTTPVLCIAFWDLIYSKIYEAGARASNYEHQSEYDEILCYGKSCYSTTFWAMAVSVWVACALWLWAWKGKQGWAKRKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA33</accession>
    <name>A0A0B1PA33_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative stress response rci peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA33"/>
    <dbReference type="STRING" id="52586.A0A0B1PA33"/>
    <dbReference type="HOGENOM" id="CLU_107649_0_0_1"/>
    <dbReference type="OMA" id="ARITRYI"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="152" mass="16403" checksum="1DD1101CEE01997C" modified="2015-03-04" version="1">MNDSDIFLGLIAILFPPFPVWVKRGLCSADSLINICLCALGGIPGILHAWYIISKYSHHDQGRLSDTESARITRYIVIHDPQSPNKVSNSSAQPFTGYGATASTNQSHHGTANQSSAFPQNVSGPVEGNENISGLPSYQEAIETSFKVQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA39</accession>
    <name>A0A0B1PA39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pci domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000995">
        <property type="protein sequence ID" value="KHJ34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA39"/>
    <dbReference type="STRING" id="52586.A0A0B1PA39"/>
    <dbReference type="HOGENOM" id="CLU_017745_1_0_1"/>
    <dbReference type="OMA" id="IPCNIIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="564" mass="64188" checksum="9CE19BEEE58803DD" modified="2015-03-04" version="1">MLIVDQYLTSIAGFLKTKDARQLQTFLRVEPPLPDEFTHLSLGIKDLFPKEAQEALDGRNEKLDRYIEGFLPVSENESIDTNDMICAWPGFQVLIREYFKFWRDVDFNDLLMTHTFLSEVTSACIAALSHPVYGIFVLPATVYFCSCLAKLTITLDKRPDLTARVRNVADEGERKSLAEHSAETILRAFTICLTERSPKKNGYLKDGHPESKKAEIYQFANMVLKLLYQCKKPRLASQIFTNILQNSPPLANYATSKRVTYLYYLGRYHFASNHFFYSQQCLEAAYCQCLTKFVKHKRLILVYLIAANLIIGRFPSRVLMSRPEFADIIARFLPIIQAIRTGDMILFKKAFSPELGNQRWFFEKGVYLPLLGRCEMLVWRSLARKVFLLTYQFPIDPNSRRAPTLDVSDVVVAAQYCQKILEGWRQAIDNLELLQSGRSHTNKIFMKPHELVGPLKGPKRLVAQEGIIFGNQVPDVVHVEAIMASLIQQGLIYGYLSHSQGKFAIIGSKQRGGPVKAGFPNVWETLKLKAEQEGKDVEIPGWVQKERNIGGVINLSGVGLQSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA87</accession>
    <name>A0A0B1PA87_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001198">
        <property type="protein sequence ID" value="KHJ33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA87"/>
    <dbReference type="STRING" id="52586.A0A0B1PA87"/>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="OMA" id="QTYCKGR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000027">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="116"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="436" mass="49211" checksum="4B716AE920655C44" modified="2015-03-04" version="1">MEPQSVITPPCDPWPRPYVLENGLRRVAPYHFTYNTYCKQRWRGRELLDIFASEFRDRSVEYYKDAIERGAVVVNGKRVETTSHIIQNGDIISHTLHRHEPPVTALPISILHEDDDIIVINKPSGLPVHPAGRYNYNSVVEIMRAERGHQWNPLPCNRLDRLTSGVMFIGKHAKAAEKLSLQISERTVRKEYIARVNGEFPLGDIVCDQPILQISPKLGLNRVRASGKSARTVFKRLAFYSLSPRKSDGSDVPSDEKGYSIVRCLPVTGRTHQIRVHLQYLGHPIANDPIYCNKRVWGANLGAYDVDATVNTDEDIITRLSRMGKSEVASAVAYHDEMVDEYNKKKAEKLSGEVCEVCSTPLYTDPSEQELSLWLHSLRYEDSKGSWSYVSPLPVWALPPDGEMGPREVGDIEELVAANSKNTEFSKSESTKLDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAJ9</accession>
    <name>A0A0B1PAJ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative duf726 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001114">
        <property type="protein sequence ID" value="KHJ33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAJ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAJ9"/>
    <dbReference type="HOGENOM" id="CLU_001695_1_0_1"/>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1146" mass="126897" checksum="AE19E0CB31F4B8FD" modified="2015-03-04" version="1">MPENTDVANTSHNSNGAKSRAIVNRKDNIELPLGVSLNRVSILVEEYDRKDARSKEKTYGISRRRSQLSRSSSKSNHENTLEGSEKQTRSHDNSLLESQSTQNPERSLSDKISSSDIEKENTLTASSQNPVTSTTQKPINEKFNAAKLESQTTSDPLESTSTLEANDNRFSQTRNANDQNTKSLGISEWSHQAFDKKDVSQDQDEGEWQPMPSYAPYNIYDDDNRLIAVEKEDSDSDNETCAAGNGYTRLQVDDDAQSATSLDENTQYLFNDCTGTGAGEMEDEEQRDTVSQLQATKNLLTEGQRIAYVGMVRLILSTMIRQSEKLISIGDAKKETSMAAEAMKMWSQKMMLRLYAHMEISSAEQIMIEQLSEHGVTPKDLTETLMQNSRVKNPMAQTGNLASESVTEENLKFSENSMSPLSRDSHGLGVKELDSASDLPPYIEHVAGEDLPEVRTPSQLPKTENLDIDLRWTVLCDLFLTLLADSIYDARSRTLLEKVGENVGISWLEICRFEKRVTDALEIQQQSEKESWNEDEHKENRRVMDLKKRYVMMGLATVGGSLVIGLSAGLLAPVIGAGLAAGFTTIGVTGTGGFLAGAGGAAIITSGAAASGGLIAVRAADRRTGAVKTFEYRPLHNNRRVNLIVTVSGWMTGKVDDVRLPYSTVNPIMGDIYSVLWEPEMLRSMGDTINILATEALTQGLQQVLGSTILISLMAALQLPVVLTKLAYLIDNPWTVSLDRANSAGLILADSLIERNLGTRPITFVGYSLGSRVIFSCLKELSRKGAYGLVQNVFLFGSPVVAKKDEYLKARSIVAGRFVNGYATNDWILGYLFRLTSGGIGAVAGLAPVGCVPDVENIDVTELVPGHMSYRTAMPRLLRHVGWIVESDEFVEIEDPDPDNHQERQRELINEIEEARKQLEKKEKEKVSRVKFAFFNRKKKAKKKADWETYVEYKKDSQQSKSRVEDEHGNNHGILFDVEAIRAELASEQMEVRELKSTLPPMKLDLDFSSARDLKSPKSKDQNQKMTSISASVPDISLTYENPQDQNFLALNTIHGDHLSSLYGVNQQKVGISHEINSLPISKSESDLSLPTQSFGENSNSGLKPMSSSPYSDFSKALETSPLDLIHNAWADNDELGEKEIQMTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB00</accession>
    <name>A0A0B1PB00_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000403">
        <property type="protein sequence ID" value="KHJ35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB00"/>
    <dbReference type="STRING" id="52586.A0A0B1PB00"/>
    <dbReference type="HOGENOM" id="CLU_015678_0_0_1"/>
    <dbReference type="OMA" id="FHESTAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="373"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="661" mass="74712" checksum="F5F7C4C3B3124686" modified="2015-03-04" version="1">MDLRSIINTESGDNLIEKQATLVTPVDENSIEGSSAYHHPTNALPDKHIFQKYGSQEPEISVVATYEQDFQYQGRPPLPIIVPSSNYSRSNSQTISANSPHQVALSSVTGHFPYLPGQQTPESPVQSYQFIAESQKRKNSQYSNTPHKIESQHTYNQSPPPQSPITSTLGSPDSHPAIPKTPISHNHPTRILNDQYQNSNFEKRDRSISSSPESRLSSLQKQDLSSDSEREKVNFSSPRIEKVLSSSMQELEPKKNSNNQSTLERTSSDNYGDTHLPLILTQSTRKRNRYSEPPIWARSVKTYGAIIIAHQNPAQLKEEQPEVEATTTQAQHSAKYNESEINSTASKATIVESHPSVILGSWEDSITGMKPIEHMTKVVADFLYLHVVSRNDLEELSAKGVQIEIEAKLGELINKDTNQRFFLPVMSECILADNLRVGFKSSMTEKQHQRLNEFLNEMVMNSHTNNSSSKSRVKIDYLHRREVDKFYDIPKELQAALPTVIKERMPPHHSAKLRVTLDQKSKKVLAKIIKARVINLDIHGGIFGTLDCRISINLEMPINDEFDELIAAGKTSNQSRDRNKDRLSYTQTYYQIDLTQITQNLSVNNDLRTEKEHELEIEISTSAVIDQGRRASRGDPNEYLPLVEGLLNNVRVLSRFVNEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE7</accession>
    <name>A0A0B1PBE7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2202</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBE7"/>
    <dbReference type="HOGENOM" id="CLU_000480_0_1_1"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="452"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="15">
        <location>
            <begin position="2134"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1684"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1796"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1929"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1969"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2481"/>
            <end position="2500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2484"/>
            <end position="2500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2500" mass="280107" checksum="7D140C060CF7D96B" modified="2015-03-04" version="1">MSSQKSLRASGDLPLLLGLNIRARNNSQTSIPESDTIDNEQLAQALDKIHITASHSETLTVFNEFAAPPSSASNTECKSITGDIMQNGLSGLYSRFRGAVGVVKEKTGSSLTSSSQEISSKLHLKDHKSLTKNLKGVAADQRDDDDDGEIFMTTNTIQGLTTSYKNSSPNSSYSALLLEAQSQNLKSLKAPLCSTTVTNPASGTSKPISSGRLSITSMTRATTSKAIDPTVAPINVSAFKNEDFVQGNIDNNIVETTNCTNPTTRNNSTGLKPNDGRQKQQNIVDNSLKEPLKVNEGNSNNAGIKATPDHEPLGGDGMIEKSKRLSGPTIATTSTLSSTLNVETARGNNLSVSNLAKKPTVMDHKSQPHLHGFQVSIGSVENAIAEASSLNTSAQNSAYHGSFSVDEKSQLAYLGMHRTAGTISNDGSPEVVNVRLEQMRKQVLSKEFWMADDICKECFLCGDTFSAFRRKHHCRTCGCIFDSKCTSIVSGQRFGVQGSLRVCTTCLDVINRRHDSSGSEDSADESTLPIILQSQHYDNGPIPQANIQESLFVPGQENEPSDGNTKSRPLATPMMAIPATRRIDDSTNRRSAVLEIDVPQLSRPSSSRSLIGLSTGGRPPSSGHKRHHSKHNMLSRFKNITDERPPFHRGIIDDLGNKSKLPAFHDDNIIDPDLAPYMSDEGSSADEQLSIFATINQANIMSPMFDNERLGFGSLSSNGKKHRVRTAEKSISGVSFTSRNIDDFNGNTSMGGFSRQNRRRNLSATNNSLHYARTSPRHQVSGFGNIDEKPAGKEPSSSLGNSRMIRSASMRDSKAPPIELNSASLHHVRRLLYQLLNDANIPNLVSWEKALLPILLQCTDDVNPNVRAGDDIDIRHYVKLKKIPGGKPGATAYVSGVVFTKNLALKSMSRTISNPRIVIVSFPIEYQRHQHHFMSLEPVIAQEKEFLRNMVNRIASLRPQLLLVQKHVSGLALQYLTEAGIAVAYNVKQSVIEAVSRCAQTEIISSIDMVVLKPVRIGKSAGFDLKTYVHEDIPYKKKTYVYLSGCSKDLGCTIVLRGGNMETLIKMKRITEFMLYVVYNLKLETSLMRDEFVLIPSIADNNVGANISDKQILTESSDKNLKNEYADGKSKPKNDQNQKNESQFTAANQIVKTMPKKQDIASTSITGLNPNNHELHVNRPGEDQLPEDIPMPTFYSDIVAKYQTKILSASPFVKFVQPYLLMRAREQERRLIYFKRLRDQDNYEEQTEMEKSKPQKFQLIKPEMVHNPVKGASRQIMEVLHAVHDAEYDKALHNYQTQKRQWENYLQGSLDLFEPYAHQNITVLYTVVCTATSIPCAGPDILTLVFYNEHVKFDSDCTLGQYVEDLCLNANITCASNGCERKMCEHHRTYVHGEARITVFVEKFPCKIKGLQDSILMWSYCKICRKETPVMPMSDNTWKYSLGKYLELSFWSTKLHLRAGLCNHDIHRDHLRYFGYRNVAIRIHYDPIDLLEIIVPRARITWKVDNDLWLKNKIFSKFEERWNRFMASVHSRIKGINIDSVAPEKADACKAEVERLTKLALEEHGALIRKLQQKYMESKYYEVIPLNRAVREMQEKVAKWDDAFADFDANFFPSEKDIRRLAALQLKGMFIDRDESTPSAISVDAPEVIPDLEKKSYDTMLNKNPNASNFSVDEAQDEISTVVEESKNKLQPPTSIEKKSPEKQPTSSLSVPDIPISIDQSISHIDILASAKKDATSIKNLSSVVPLNECSPKDNLMSFATTSRCLSGSSLESIQSENEEKLHRSNQSIAESISSLSEISGIPRPTERVSSRRSISVVSPTFGRNQSQPPHALRRANFKARVKSKKTNHISGSGIATPPLEATTHLGVEQVKLTEKKHLENLDLGTIKALRKAGHSMIPRSIHHKYKDSKVSNLAKHFEQLSREFEKERLRDRKQRREARVTQSRTFPKASSKPIVEVYRDVNEAVEERRHTDEDLCTPQTTEYDSLAPGTPKEVEASEAPLAIDDSGLLSPTGTMATGDETVTEAEYNQQTTSQAESDEEGTVSDVENSLLVDVTPSNAEKNEKLRLRKPSTEMSLEIPKHEKNSLMKLLTNFWAERSASGWTPLEYPMSASDHIFEDVDVIVREDEPSSLIAFALQTQDYKDKLEDIRRQGQLSNENSGPPNRDTTELQEISEDGLNQAGVEKSLLRATGTHLAYSFVDGSARMQCKIFFAEQFDAVRRKCGVSERIVESLSRCLKWDSKGGKTKSVFLKTLDDRLVLKSLSPIETAAFLKFAPAYFNLMAEALFHDLPTVIAKLLGFYQIIIKNPTTGTEIKWDVLLMENLFYDRSPTRIFDLKGSMRNRKIQSTGEQNEVLLDENMVEFIYESPLFVREHSKKLLRAAIFNDTLFLQRNDVMDYSLMIAVDETRKELVVGIIDVVRTYTWDKKLESWIKDRGFAGGSRNRPTVTSPKEYKSRFREAMNRYILQAPNSWHQLQQVERKHTVNSPNSTPNQLLRIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBM1</accession>
    <name>A0A0B1PBM1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative snare domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBM1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBM1"/>
    <dbReference type="HOGENOM" id="CLU_059257_2_0_1"/>
    <dbReference type="OMA" id="LMTYTKQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="177"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="271" mass="31161" checksum="3AB65ED51C8E8C53" modified="2015-03-04" version="1">MSFNQLSSLESQNVGFQRYEDPQYVDDPEFQKLSKELMAKLFTLTGNISRINNEVALIGTKRDKERLRERVHNLLKESKEVFKEIGQGVKKIQSWEDINPSQKYIQQKLAREFQNNLFEFQNVQRLALEKQRTQASVERTALEDQQQQSVLVEGQQNQEQALDQLRLASQEEVDFQDSLIMEREAEIRNIEQGVTELNELFRDVALIVNEQGDLLDTIHDNVENTRVDTQGAELELRSAARFQKQARSKACCLLLILGVILTIIIVAAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN6</accession>
    <name>A0A0B1PBN6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000144">
        <property type="protein sequence ID" value="KHJ36117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN6"/>
    <dbReference type="HOGENOM" id="CLU_1908238_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="133" mass="14913" checksum="71623E6155B13047" modified="2015-03-04" version="1">MRQSIIMKLTSSPFGWIDLSRKARGLGQGSPGSSNGDWLIKKVYSGRDKEVFDAELNGIEQALEIACRAGQLLAQQTSQATRQKLFSISKVHVRLDSKSAIERIKNLRLGQVQWLARRVSEHTSILEIYMNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC78</accession>
    <name>A0A0B1PC78_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g0182</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000815">
        <property type="protein sequence ID" value="KHJ34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC78"/>
    <dbReference type="STRING" id="52586.A0A0B1PC78"/>
    <dbReference type="MEROPS" id="S53.010"/>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OMA" id="VIRTMNY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059523" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="219"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="590" mass="65125" checksum="2A27A0DE593DA3F5" modified="2015-03-04" version="1">MKLVYAIVLSAAAAVLSQQQFFIGAGDQYKTFEQLAHIPYPWNLKETITLDPKHSFKLRIHLRNQNIQSFHRKVLDLSTPGHPDYGQHMDREAVNNYLAPFPESFDLVQGWLEYEGAGNVTVQNDWIILDTTIEEVEKLLNTKYQVYENNETGQLILRTLSYKLPSSLHSHIDLVAPTIKFSTPSAHRSTLVDWPYEEETKSANKEILENGVSAECNNSITIDCLKDLYNLRDFSPSSNPNNQFALAGFLEEYAQHDDLKKFLSTYEPAAAKSDFSTILINGGQNTQQNTVDYPLNMGEANLDIQYAFLAYPTPSIYISTGGRPPETPNMEVDNEPYLEFLTYLLNATEIPRTLSISYGDSEWTVPDSYARTVCDMFSQLAARGVSVLVSSGDSGSGSNCTETEPSALRYTPSFPASCPFVTTIGATYRVNPEVAVSFSGGGFSDFFPRPEYQDSTVTVYLETADPAFKNYYNTSGRAYPDISAQGVNFHVFVRGTDVLESGTSASAPAMAAIIALLNGERIERGQPPLGFLNPLLYGEFKAAFTDIIGGKTSGCPQVQGSGFAATTGWDPATGFGTPNFKRLQELSNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM6</accession>
    <name>A0A0B1PCM6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative duf803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCM6"/>
    <dbReference type="HOGENOM" id="CLU_012349_0_0_1"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="417" mass="45642" checksum="7B99969FBC751DE2" modified="2015-03-04" version="1">MLEDKYIGLALAITSTMAVGTSFVITKKGLMDAEERHGFEGDGFTYLKSPIWWAGIIALIVGEVANFAAYAFAPAILVTPLGALSVLIGAVLGSYFLEEKLGTLGTLGCAICLIGSLIIILHAPPDRDIQTIDEILHYAIQPGFLTYCLVVIVFNTIMIYRIAPIYGKKNPLIFLSICSTVGSVSVMSVKAFGIAVKLTIAGKNQFTHPSTYVFVILTGVCILTQMNYFNKALSQFPTSIVNPLYYVTFTTATLCASFILYGGFNTSDAVNTISLLCGFLVIFLGVYLLNISRGDLGEFRNQVNCLHHDGIATVPLSQLSTRRSMQLRRSMDHHRMSVDSSDYSKGDRQGLIRAYDEENIGSFALQDLTEESDEDIALRKSNGIINGITRKNKVVSDKKKSTSNRLKPGRVEKLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCT0</accession>
    <name>A0A0B1PCT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative te1b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCT0"/>
    <dbReference type="HOGENOM" id="CLU_1826729_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="15310" checksum="78B1D64F2A9514FB" modified="2015-03-04" version="1">MFLRNSGRLFVAKVYVSEFHGTMYAMEAILSSGKDNGYTTIYVMLDSSSAINALQSGITSSSAGRVENFQMMATISDAPVKVVWIPGHEDIARNVIADQLAREALNSQDLTGLGTRSLPKILTIIAIENQARKSAKELIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD30</accession>
    <name>A0A0B1PD30_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative rna-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000457">
        <property type="protein sequence ID" value="KHJ35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD30"/>
    <dbReference type="STRING" id="52586.A0A0B1PD30"/>
    <dbReference type="HOGENOM" id="CLU_004133_0_0_1"/>
    <dbReference type="OMA" id="HYKGELY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="576"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="783"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="855"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="955" mass="107154" checksum="A06293C043C0E8C7" modified="2015-03-04" version="1">MSYQNSTPERIDDLRYRSQHSPISDPSLIAMVSPSRTGTRLTQSTNSQNSRGGLMRRFTTESGRAPALSSVSSQRNSQEMQDYGQSLEKKKLEYERLREQKRLYEAEMQLLDLKQRRDEQELAQMQEDLGRCANTDQGHQSQPTTPPEFNESPSGFPSAFSRPNRYSTSSLNSPLNLFNSSGRSGTHITSPSSGSLQSRLILDDKLLSKQISEYRRTIDDDDKAEAVRQDPTSHRSTNALNRYSMPVTKTRPSFRDMSLDQINTARFLFGEDESNTSSGANEFLQVNATEENFPILVRREDYPNMLSASSAALDLALFQSPGSESSTWNSFTNGHRSTRSQQGFSLGNIQPSGPATSSKSNTNESSASVRQSYRHSLDTKYRHGFDIQQEKITQVTPSSNNQIASTTAPSKILSSFSTNDVQSTRSTINGGTNSKNTSNSRNQKCFHSHNASLGRIIPGAINILNRDSKSNESSGIREGQNVGFQSMNTALHANAPSFGPESTQSINQSAIAPPLSPNPTQSLAAQQSYYGMQMLISGMQNMSAGQYGYSSPNIYGYNGNQAFTPIRSQQPGPRENSARIIQNRRPNDADIIDKYANVSLESLDGEIYTLCKDQHGCRYLQKKLEERNPDEIHRIWLETNQHVIEFMTDPFGNYLCQKLLEYCNDEERTVLIENASHDLVRIALNQHGTRALQKMIEHITTQEQIDIIINALRYRVVELIQDLNGNHVIQKCLNKLNSQDAQFIFDAVGKHCVDVGTHRHGCCVLQRCIDHADGEQKAWLIRQISNNAYTLVQDPFGNYVVQYILDLNEPVFTEPLVAMLKGRVSQLSKQKFSSNVIEKCLRCAQEPTKDSLIEELLQPNELDRILRDSFANYVVQTALDYASLDMKTRLIEAIRPHLPAIRSTPYGRRIQAKISGNEARNNSISGQTISGEQSECYRLLPLGMNPELIRFRGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD35</accession>
    <name>A0A0B1PD35_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000676">
        <property type="protein sequence ID" value="KHJ34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD35"/>
    <dbReference type="STRING" id="52586.A0A0B1PD35"/>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="293"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="411" mass="44846" checksum="33356314717453D6" modified="2015-03-04" version="1">MKTSSHLKIVIKLGTSSIIDEKTHEPMLSNLENVVKTTLDLQKAGHKVVIVSSGAIGVGLKRMNYKMRPKHSSKLQGLAAIGQCRLMSLWDQLFSQYNQPIAQILLTRNDIADRNQYLNAQNTFRELLDIGVIPIVNENDTIAVSEIKFGDNDTLSAITAAMIHANFLFLMTDVDCLYDTNPRSNSNARAIEVVDDLSALQVDVSSAGSNLGTGGMSTKIVAARLATSAGVTTVITRSSTPGNITNIVEYVQSLKSKTPSSKDVIPLHTRFTASEDPIKDRHFWILHGLKARGTIYIDPGAYRALENKAGLFAVGVIGVEGNFVQLEAVRIVVVERDTKDNVTESKDSCVEQGTEVGKALVNYSAMEITRIKGVGSNEIEKILGYADSDYVALRENISLFRRRSSTKSGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD69</accession>
    <name>A0A0B1PD69_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD69"/>
    <dbReference type="STRING" id="52586.A0A0B1PD69"/>
    <dbReference type="HOGENOM" id="CLU_008220_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="2">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="439" mass="49361" checksum="C25924A7D555D9FB" modified="2015-03-04" version="1">MAQPICLEINTVKPNLGLTMGQTSVVTPNSPQHSSDNVLYTLEARPRSSKDSVSNLSAQSSTCLNDVKHEVMVNYLYQQQCSHLWVHDKSGNLEGVLLRKSRNTYMTYPPQLGSSALATACRALNVQCAMTVNSRVIKSFFQWSPNAVDVPLLNGLRIQVLPNIEDLSRARKHQFAAFIATETLLIVWDDEALHLAQRAKKIESELMELVWKSGEFKGDESKKLGNDLIETDEESGKNKPRDRRINLQNTVLVSLTLTLVMVTLGAGFRQLAIEVAIDGVYIRLVLLVLTPIQVFFTLFFAQVIIGCLAQMLGPIQQMSINSRFYSAQAPQRIRRVNLPHVTIQCPVYKEGLNSVIAPTVKSVKQAISTYELQGGSANLFINDDGLQIINEEERKERIEFYNNHNIGWVARPGHGDNFKRKGKCRFITHSAYFLIYLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDA2</accession>
    <name>A0A0B1PDA2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000778">
        <property type="protein sequence ID" value="KHJ34644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDA2"/>
    <dbReference type="STRING" id="52586.A0A0B1PDA2"/>
    <dbReference type="HOGENOM" id="CLU_034476_0_0_1"/>
    <dbReference type="OMA" id="ITMERTR"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="158"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="334" mass="38706" checksum="39652827F13618E5" modified="2015-03-04" version="1">MDTLLCDGDDSEVCCRARSDTSSRVRQYHDWVPSMPRRQHSIHRLPNYDSPRDTLPASYSSRSISTPTFNQDFDNYNDILVERTPAGNSILSIPPSELLHATNNLIDHQQSDISAATRVQNSFHRLPKDSKYERILRGLIRRHEPLNSGFMLDDSALESILTAADTLFFDGALAGRVQWEWSSEPRYRTEIIGTTALRRCTRREGFETLIILSEPLLRNERYDRRLLLTTFIHELIHCYLFITCGFEARVEGGHTAGFHRIAEIIDSWVGPGFLSISKLREDPERFNIHTSLGIKQRQYSNYMQWETFRREKEIKPDNPPQHSFFIPLHESLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDB9</accession>
    <name>A0A0B1PDB9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000436">
        <property type="protein sequence ID" value="KHJ35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDB9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDB9"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="610"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="697" mass="77512" checksum="558382A19B4D1B08" modified="2015-03-04" version="1">MSAPVQGGISDPGLITLVNKLQDVFTTVGVQNPIDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRQPISKTNGLLEDIASEGDKEANIDEWGEFLHIPAKKFHDFNKIRDEIVKETEAKTGRNAGISPAPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPRDIERQIREMVLKQISKPNAIILAVTGANTDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDEGTDVVDILAGRIIPLRLGYVPVVNRGQRDIENRKSITAALENERNYFENHKAYRNKSSYCGTPYLARKLNLILMMHIKQTLPDIKARISASLQKYTAELAGLGDSMLGNSANIVLNIITEFCNEWRTVLDGNNTELSSVELSGGARISFVFHELYANGIKAVDPFDQVKDIDIRTILYNSSGSSPALFVGTTAFELIVKQQIKRLEDPSLKCVSLVYDEMVRILTQLLNKQLFRRYPGLKEKFHMVVISFFKKVIDPTNKLVKDLVAMESCYINTGHPDFLNGHRAMAIVNERHSSTKPIQVDPKTGKPISTSTTLARATSPTSDLLGESNGGFFGSFFASKNKKKMAAMEAPPPMLKASGTLSEREGIEVEVIKLLINSYYNIVKRTMIDMVPKAIMLNLVQFTKDEMQRELLENMYRTDTLDDLLKESDYTVRRRKECQQMVESLSRASEIVSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDN5</accession>
    <name>A0A0B1PDN5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000546">
        <property type="protein sequence ID" value="KHJ35071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDN5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDN5"/>
    <dbReference type="HOGENOM" id="CLU_004458_0_0_1"/>
    <dbReference type="OMA" id="ASEWHFK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="878" mass="101340" checksum="1F3A8DBB577458ED" modified="2015-03-04" version="1">MTSSFEFYTSNLDRHLQESSSQNLISAAEHHLLFASEYYLKPKGVDYVQKEFKCQLDLLDLQDSLVKFKYDPEKYNFLITCSPGKSHNVWKIFHAIMTKMVREECQKSIRLHKYEDSIESTDGDSSCDDEYECYDEDLVLESDKIGRVGICEAQAQQSNLSVPSPICISTFSNISNQVDDQNFKYTYCWEDRVLKINDVFTDSVLQELSSLTGCTFIKEPNDCRIYIKSDLEASLNKGISKMDNIKNYFLPQNKIPVYHSFYTESEPNSQFAFLRISNSKNRIFKTTLIDNLSSKIGADEIKDLQDLIQDAVIIRYASFDRVSAAFQIRWKLKVVPIVKEEEKNLVSKSCRNPIYPLKDAHQEAHDLFGINQYKTRNSISRENHKEFVDIKKKLNLSSKNPQISNWVQDVVDSDSLKAEREGIEPTTTKLKNPPGKKKGPTSYDLANRFKDAPQSTIRESPKNELVLKKLRSSLISSKDKTEKAPINPKVKFEQETPRDFWSRHPGKFSVDLTDIKVNQQQQSKSVDLRLVANKIQASNLIDDFIPELSCNIPKPKKEKMISEIKNRDTLLIDFEEDTSIPTSTYTFSQADVSRNEEVLLHLPKLDIKQPPIQSKKKEGRNKNKKSAHAGLPLLDSTREIKESTVFDILSSNQETHILESFKQSFKSNFRSLMKNIRAFRGELVVEAHFGRTMTHGIKDIYISKKGEYEKTYDEETTRRILNESKSNSLTPGFTKVITTVPAEIQFIREMKDCHGLNCWSQEKTDWSLYYELYFEDRNFSHNNNFIVEINAQSFVCRAKTISELGNLYVHGTTRLWDFRVAATDIKYTDRLDIEHSELVEMISTSLFIPYAQLKVQFGTLRKLTQLGKSVHYPLSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDQ3</accession>
    <name>A0A0B1PDQ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000539">
        <property type="protein sequence ID" value="KHJ35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDQ3"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10760" checksum="307671D00A992227" modified="2015-03-04" version="1">MATTKCRNCGGPHHYISRRCLARPTRSGALTKKQMKAFRQAGEQEFLAVLRAKAAEESPTSAEDLNVRKIISQATEGNANIDMILASPVDSSMGDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFK3</accession>
    <name>A0A0B1PFK3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative uv-damage endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000431">
        <property type="protein sequence ID" value="KHJ35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFK3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFK3"/>
    <dbReference type="HOGENOM" id="CLU_017168_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="699" mass="80719" checksum="AD556FD2FBF4C9F0" modified="2015-03-04" version="1">MSPKRKLLSPVSVKILGLKTPQNPAEIFFKNHPGNDFTYPNVEKSPENEENGVKKAGIRSLTRVEDKSLNDVNDYIPSFNIKSELRNYSDTQEKREISSKSSVAPKKKKDRVIISERKNSKKNPIGFEQEERDVEDDINNNIDLDEEVMKVIEREDIERKEAERPPPINSSYLPLPWKGRLGYACLNTYLRYSYPSIFASRACRISSIIEHRHPLTKPNEAKHATRNRPDKSKTPTVESGQRYVEALCLANVHDVPKMLRWNHKYGIKFMRLSSEMFPFASHAEYGYKLAPFASEALAEVGRVTVELGHRVSTHPGQFTQLGSPREEVIASAIRDLEYHDELLSLLKLPRQQNADAVMILHMGGTFGDKAATIERFRENYKNLSESIKQRLVLENDDVSWSVHDLLPICEDLNIPLCLDFHHHNINFSSNHLREGTLDIVSLFPRIKATWTRKSIRQKMHYSEPCADAVTPRQRRKHNARPNTLPPCPDDMDLMIEARDKEQAVFELMRIYKLPGWDSFNNVIPYYRSDDNRPLPKKAKKKKSHKQTLGEIDEFGKNGEGEGEVKVDNLRKIVLEPEVGMGGKDNRVYWPPGYSKPYWTKECTRLVKEARKARRRWTKEGTEESWIAYNIAINKKKSQIKKDKLIGWRAGVTEATNDPKKIWKLAKWARRDPEEKRRPPQILDIMYALGNVHTLNIDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGM3</accession>
    <name>A0A0B1PGM3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative nuclear membrane fusion protein kar5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000035">
        <property type="protein sequence ID" value="KHJ36400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGM3"/>
    <dbReference type="HOGENOM" id="CLU_1416139_0_0_1"/>
    <dbReference type="OMA" id="KMNIDAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="22276" checksum="CD33670F52B29FE3" modified="2015-03-04" version="1">MAAYLLMNNCKGLNEIDEQNYSINRGRIQQDQVDAFAATLTMCDMERAKFDVPKPCFHFTSISLMKTAELKKDLKFSSQEVNDCLQGLGKNAKHWATWLSYRDSALLFCRAARLSIERDETIALHRELMVIMKDFTRDLHLDLQNLKDKVSLHKDLIDSIFKKMNIDATDWRFKLNKIFGDVSQNINVHLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGR1</accession>
    <name>A0A0B1PGR1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGR1"/>
    <dbReference type="STRING" id="52586.A0A0B1PGR1"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="48123" checksum="0DC81168368E8436" modified="2015-03-04" version="1">MSSDTEIQALPTDMRPTPPPPPAHSAPFPLSPSSPNILTSDNNCEHYTQSSRPILAPAAPSKRAAQCVAEQVSQSFEDESDQSHAYLPQDLRGIIKQRRRRERAWHVRLSICTSVFCKIEGTLLVFKDDIEEEEADIIRNYLQQAIARLVASDNAMKFPPILHHTEPHVTKGSTQENVIPKKKASIIPLTSLTNHKAPQPRKREQELQCDNNNKIQQNSWATEHELRKLSPAGIREMIVKRLYVSLIGLIKPVRSGFALGSCSIEAREELLKASGGLFLSGAKLEPVNQWVTPLIPTVPRSINTLQGHMEVSKEMLSDEIERVSSARPEALKFYGNHKPDAPYRTWLAFFTKPPKPGLRLFDESGITHLLKKKFQLIPANVAVDITPQNSVHEHPHMETVARICTLKIIAWPPLGAEIVEDLIDPTVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGT6</accession>
    <name>A0A0B1PGT6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cys met metabolism plp-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000154">
        <property type="protein sequence ID" value="KHJ36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGT6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGT6"/>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="OMA" id="HKKMHGV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="423" mass="47311" checksum="440112251657304F" modified="2015-03-04" version="1">MSFTHFDTDEKQDDSSSLIFSNSSLAIHADDFLNGDQRDVAPPLHVTTTFRYNKDPDSLVSSRSHDMQSLSTGTHIYSRISNPNTTRLEALLSSILKGPTLTYSSGLSAFHALLVFLNPKRIAISDGYHGCHGVIEIHQKLTGLKKIALDCDPEELQAGDIVHVETPLNPTGEAINLSYYAEKAHSRGAFLTVDATFGPPPLQEPFLWGADIVMHSGTKFLSGHSDLLCGVLAINPTRIKESWHSKLYQERVYLGNVMGSLDGWLGIRSIRTLELRVIRQSDNALKLVNWFISAMSAEEENTDIAHYRGIEIVQKVLNKIEHASLQQEAIKNGWLLKQMPNGFGSVFSIIMKEESFARKLPSKLHLFHHATSLGGVESLIEWRTMSDSKVDTHLLRVSVGIEDWQDLRNDLMQGFEAVWKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGY7</accession>
    <name>A0A0B1PGY7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heat repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000264">
        <property type="protein sequence ID" value="KHJ35774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGY7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGY7"/>
    <dbReference type="HOGENOM" id="CLU_005544_0_0_1"/>
    <dbReference type="OMA" id="PHPKKPW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="2">
        <location>
            <begin position="754"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116995" checksum="DAA565AB05A3899A" modified="2015-03-04" version="1">MDNETHKSARDKLFRELKPYCVKLNQLAFLNTGSLKNHDALINTTAELSIILEKNCAPTENGFDHNLADYVFYPLSQILQRREKTTDRLLELTIKCVKIILQYGWRQSIALELAKQLLILLTFMARGQPAKESSLASEEILFEALGALAALFQAVENTDKGPASFKEPKVILALGFCVTTILDSIAESYTAKLQLEALSALDAVWHCIQSNEILSKFLPGVVSTLTKCLTPSTKIRRPRRVLVRALEVLRYVLTSTLNDLSTRKVKTSQKCLKILSTSDSHQEVLTDEWLKVTSEQLRLALINIIKLRSHEAVEVQRALNSLCIALLDECHDTLSNSHQILVETCMSLYGIDSDNQLYNRKTNLTDLAFIYTNLIDLIQETAHNWMISLPKIMQTSDDTAKISLIKKLSMTQELFSCLHLRSNFLDEVFLKSLRDCITVTIDPLIPSKSLQETNDNLNSQAVSNFIMPNTNSMTFRPIIMPLENQKKIRENFMRLVNNLSPRESHVQLADEMLEYTRSASGSSLLSSYWLSFQILKSMTKNEEFDDLLNTTCLMSSNCQQESLEQELYSFSLSLLCKNDANHEMMDWRLPAVALEMIAYFALRMGHTFRTELVDTLYPVVQLLGSPSSELREHAITCLNIFSHACGYNDSSALIIQNVDYMVNAISLQLNTFNIAPQGPQVLIMMIRLSGPSILPFLDDTVDSIFAALANYHGYQKLVGILFSVLAEIVSVSSKSHQNQGIKRQISHQKQLPPVITIKQIIDSYITITTPLTPLESEEILPHEPFPHASWKSIESTPEDEEMELEHDHPTDKTQMENQTHSYEKKTFQMLLSIARLCQYYLTSSSPILRARLLDLLKISINALYSDEDQFLPLINDIWPVVIKRLYDPESFICIAACDLIAELCRCAGDFLATRISVEWSDILKLAHAKKLNVISEKKRYGSNVKFTQSSQVWEALLRMLTAILKFVNIQDVMFDDLLELFGSITWEREDINNALTQLNAEAVWLAMLISGCIRAPTTPELDGYIYVNYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHE6</accession>
    <name>A0A0B1PHE6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000178">
        <property type="protein sequence ID" value="KHJ35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHE6"/>
    <dbReference type="STRING" id="52586.A0A0B1PHE6"/>
    <dbReference type="HOGENOM" id="CLU_031381_1_0_1"/>
    <dbReference type="OMA" id="RYEYARE"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="55923" checksum="A3898613DEF62B94" modified="2015-03-04" version="1">MRGVLVAAAFFSFPFRIKSAQSNITNLEAPTEIVVPATFDPPQAFKNINLVHIINLEKNFPRETVNVVVENVDNAPQDEYYISFTSEQMKAVGALEVRDRNDLDKGSLELQTIRVENEEEIQYYRIKLPKPIIPKSQITLGISFSYLSAFNPRPKAIPQAGNQFLEYEFSALALSPYPTLNQKTEIKFPNSNVPEYTKIPELDGKAEFPIKAGSKLIYGPFSITPARATKPVKVRYQFTKPLIHVSSLERDIEVSHWGGNIAFEEKYRLRNRAANLSDLFSRVEWASSAQFNPQTTAIREFNIPLKVGSLSPYYVDIIGNVSTSRFRSNKHEAKLEIKPRYPIFGGWKYPFRIGWDSDSKNYLRKLKARDGYALNVPFLEGPKQAEGVEYKSVEVRIILPEGARNVKYSTNISLISANISLHKTFMDTIGRTTLTLAAKNIFDNQRDQELIVTYDYPLIATLRKPFVLFSGFLSLFVGAWLAGSLDLSIRAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHI2</accession>
    <name>A0A0B1PHI2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2432</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000088">
        <property type="protein sequence ID" value="KHJ36271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHI2"/>
    <dbReference type="STRING" id="52586.A0A0B1PHI2"/>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="208"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="341" mass="37442" checksum="5AB59275A868949A" modified="2015-03-04" version="1">MANESNAEKVNINIVTLTRFLTEGQVRQKEATGDFTLLCHALQFSFKSIAYYIRRATLINLTGLAGSSNTTGDDQKKLDVIGNELFIAAMRSSGKCAMLVSEEEEEAIFFPEHPNARYAVACDPIDGSSNLDAGVSVGTIFGIHKLAPGSKGEKEDILKPGTELIAAGFTMYGASAQLVITMKGGGVNGFTMDNALGEFILTHPEMKIPRSKSIYSVNEGNTLYWEDSVKNYFNSLKFPKEKGVAPYSARYIGSMVADAYRTLLYGGIFAYPADKKSPKGKLRILYECAPMAMVFENAGGQALNSRMQRMMEVVPEDIHDKSGLFMGSFEEVEEVKKFHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIX4</accession>
    <name>A0A0B1PIX4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIX4"/>
    <dbReference type="STRING" id="52586.A0A0B1PIX4"/>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="8">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="28463" checksum="182F5B2DD148EDD9" modified="2015-03-04" version="1">MASAVSSTAISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVLNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKSGPQKALPDSVTIIEPKEEQTIVQPISTDYGAKAAAVQAAADVANGTDPSEEIILDELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVK3</accession>
    <name>A0A0B1NVK3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative trafficking protein particle complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005837">
        <property type="protein sequence ID" value="KHJ29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVK3"/>
    <dbReference type="STRING" id="52586.A0A0B1NVK3"/>
    <dbReference type="HOGENOM" id="CLU_087110_2_0_1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="119" mass="13703" checksum="D39CA2E94DAF6ACB" modified="2015-03-04" version="1">MKRCLDFRETAEMIAKVGFKIFLNITPTVSSWTSDSKQFSLIFDENPLADFVELPDDGRAQDELWYSNILCGILRGALEMVQMQVEVKFIADILRGDDQTEMRISLVRYVDDEMPAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW32</accession>
    <name>A0A0B1NW32_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004859">
        <property type="protein sequence ID" value="KHJ30178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW32"/>
    <dbReference type="HOGENOM" id="CLU_802132_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="346" mass="40561" checksum="25AEC1EA4AD305FA" modified="2015-03-04" version="1">MHHNIESNGDHKSQLNFKITGLSKLYNLSEKYSGSKNDNLSFKFNIFQQKCKIVNITDENDLASSIFIMFVDEALEFYHLRCGGSHNTEQVINTMREQFEGPQKQRNAQTEWNKTTLRAFSLKYPDKSLPNVFEIMVKQLRKMQLCLRSNFQDEITLRDKILEAVSNTPECQSACLIPEESLNSVINNIRGAIGMSASHESNVDEAMFVNRKFHNEKRNGFQNKNSRFEQSYNQPTKSFDPRIKRCYCCKKIGCRSWRHTKKEQRDAKERFYQRHTSDNQKKFQQFLIEYEGITDDDLDEETMILDKISVEDNEEPISGLFITAQDYDYSDQETNQTYTTSQHHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWU0</accession>
    <name>A0A0B1NWU0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003614">
        <property type="protein sequence ID" value="KHJ30792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWU0"/>
    <dbReference type="STRING" id="52586.A0A0B1NWU0"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="138" mass="15211" checksum="17D3CC4C41B29A85" modified="2015-03-04" version="1">MSDREFGGNDDLSLPKATVQKIVSEILPPSSGIGFTKDARDLLIECCVEFITLISSEANEISERESKKTIACEHITKALEQLGFGDYVQSILNVACEHKEQLKGREKKANKLEQSGLSTDELLAMQEAAFRDAAKRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX54</accession>
    <name>A0A0B1NX54_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003988">
        <property type="protein sequence ID" value="KHJ30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX54"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="96" mass="10467" checksum="5B0E9418AC6C1832" modified="2015-03-04" version="1">MATTKCRNCGGPHRSNSRRCFACPTRSGTATKEQLKIYLQAREREYQAVLRAKAGEESTAAAETNKVNLTSSHESDNIDNILASPIDLPTGDATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX80</accession>
    <name>A0A0B1NX80_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003922">
        <property type="protein sequence ID" value="KHJ30588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX80"/>
    <dbReference type="HOGENOM" id="CLU_1070366_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061533" evidence="2">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28627" checksum="E2C04F56BB7A82BA" modified="2015-03-04" version="1">MHVLGTKGVLSASLLALWAVQITDATRTNTANAQYLLIEDGFGVTSYGFQCLDQVFLKYDIFSAAKQYCDSIAIKPELVSQSSQEAGYRRMLSPETIKAFVQQPRRLSTLTLIPILEDVTLYPYITPSDLRENKNSQGVKDKPAAGAYRLIIDQNCDVVGALTDLAFTSESDGGIVRGCKLLRSPDDLDIHSSRSSSSWDGSPFRSPFRDINELPAGDHSNSPYISTKSSPHTSPRRFPHASSQRSPGRSPERSPERTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX95</accession>
    <name>A0A0B1NX95_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003353">
        <property type="protein sequence ID" value="KHJ31007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX95"/>
    <dbReference type="HOGENOM" id="CLU_038480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="426" mass="47410" checksum="49845C30EDA893F1" modified="2015-03-04" version="1">MATDLQAQLITAFQQIWSNLASAIRGHQLTDDSNPVPLLSSIASTTDTPEKKKFCSLLGCYDVKFGEMKAQLESYNSRNSKSASELVQVQGEATELNKAISLAQQEILHLSQSSSQKSAARSPFSGHNDNDKIAKLNDKVSTLQAEYNRLPATHNTSSTKNSEVNDGSASKARRTRSDPEEFSGTKKDTEKRQMVYESWKAQIQQIFLVDGNCFPSSFHIISYITSQPSGKAWLAVQDGTAKNALDTLFQGKSAYGDFIADFDHLAEMAKYDDRTKVNLPASNNYTGWSDMINTIARNLQQQEHIAKLQAPTSTIQQNNPNEPNQNFEHDDPMDLSRIRLSTAEKNYRMENGLCVACGNSGHIAKDHHRKIDPIPMPRRSKNLIASRGNDNDNRPSPKQNFSPNQKIIPPNNSQPLPTPNLHYSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXE6</accession>
    <name>A0A0B1NXE6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003298">
        <property type="protein sequence ID" value="KHJ31067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXE6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXE6"/>
    <dbReference type="HOGENOM" id="CLU_691151_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="44345" checksum="EFB68598F9B64CC1" modified="2015-03-04" version="1">MTNTANIDTLMIDENNTLLNRLKYERTKLTLTKFASSNKSLQSANQNFRRSPESPNLLLSQNSFSNTSISSICFGNRLLGMAGKFNTQTQNQSILVPLESLSHKPVDLDANSHPSLSSGDIDSIDLSSQPGIKDLLVSAEGLLSRLQNAYVQRTSALNDMTKSRDNLVEELEESNTRVQNLRSQLETLATTISSKDQRIAELERELLSAKSNPCYYKSSLNKCHKLQNSNSLSQSYSSIDHECLTPEDHNCTNHMLIDLELEHESDCESSICDELFSRPQSPALTNTSSILTRSPHLRPVTYESPDPSLRNFDNKNSYCNERPKSQPYKSFFGFLSGRSSNKDVHTLQQESCPSCLGKGSLAAWDTVSLLQAENQGLKGRIVQLEDAVSGALDAIMGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY24</accession>
    <name>A0A0B1NY24_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003531">
        <property type="protein sequence ID" value="KHJ30853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY24"/>
    <dbReference type="STRING" id="52586.A0A0B1NY24"/>
    <dbReference type="HOGENOM" id="CLU_005931_0_0_1"/>
    <dbReference type="OMA" id="RSDHITK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="183"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1159" mass="132151" checksum="672B54F90F800CF5" modified="2015-03-04" version="1">MSQSTVNPETVNCALEDYFDWEYKAWVEILADLEQDTKEHFLPLDAVRSYFTTCDSQLQRNLDKILVEIFNMDSPPVNSDLILRDHIATFCILLQIDRGRYIEHFTCFEELSDNRLPFDSAHPPGPFPTVMGDYTFFQEFCEVQRRYCVPIFNSHMLHKNFGHQRLLPITFKERLQTRGVAAAHIIRLYGPHNKMTRESVKVKNPNSNTFVIKSYSTTRDHDLYTKQVNTFRSFKNADGILKFFGSFEYRGQSHILLEFADKGTLIDFFKTEAPPTRGDQIIDFWENILQLTKGLKAIHSVKGIHNDIFSENILVLSNGTRLPSNWLFKFSNPGTMSESNNYTGQLASMSIPEDSSSVHLKDHVINIESKSDHQGTKSLVNVDIWRLGCIFSQAAFWIADGYKGILDFERKFGDNIDIIKTLRIQEEKKISENIIDAHAEIENHLRRSDHITKDLLTDMIDEMLWPEDHPNIDILIEKAESMIATARQTLSEVSSKKSSRPRSQSRNTSRVCSPAPPVPLILKKDSTELPLSKPRFPRRCGSLRVNFNHHSNSLSSKISVASDINSSASGIKTTNLYTFNSMSKITSGLENKSPVTSWFLDSPTTDSPFTVPRLPSMRNKQFHSLSSESDLTFAKETSIEINLPSKSYQSKNPSQAFDESRETDTTNKSFVNNETVRSATYEVCLPSKQRTIPLQNTSHEYRLPPLAPYKSPFQNMQSENVKPFCPQFESFTESNHQSLSACTSINPKINPEESYPQSRPHTSIDVKRHNSIHRLKLENDTYQRIFNLSDQPIPSSMETSVISNDRCCNESISSSACSSLTNKSAASSFLSKSCRLSSFNSRRNSLRSMPENGVSLSRTATARSTFCQSLNEFHDQNKIAHIDINTCRYWKHLNKTSRRKSKVPLLPGAYLLLPLKKYDHIFIIDDSVSMAPHWPEVCLVFESLSYVVKGMSPLGTQLFFTISSESLRKKGTHDLCQFVSEKRLQRAQTNIAKRLDLQLAAYRLKLWESNKRTRDVRPVNFYILSNGLWTPESYEKLRDTIEQTALLLSQFGLKNQVYLSFIGFESTSAAAHSIETLSSIDWGDGLRVGWSWWTGNIWGMLRGDLVNIERNGSTLCYTNEPPVDEKNYDQNLIIENKVFMSGFNGNQVIGEVEGLYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY82</accession>
    <name>A0A0B1NY82_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005738">
        <property type="protein sequence ID" value="KHJ30000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY82"/>
    <dbReference type="HOGENOM" id="CLU_874915_0_0_1"/>
    <dbReference type="OMA" id="NSSCEIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="318" mass="34832" checksum="9085D990228451E7" modified="2015-03-04" version="1">MPNPRRTYPTGGNVDQGPDPTGNAFINMFANGKDQVDFTDHRQFNAPLLPLPTADDDMHTIKRKFMDFAMVVNSGKSVAIRTGYRAPAQEKRDPVQVAKQSMTPDEIMQYDAWAAGIMPPTFNWEVDRKPVAGGAGAQARFEKRARAARRIWGNNAIVPENISWIAANHNYILPLVIAMAKIVAIGMDNINRQQELIKCALRDITYAKDTLQARMNAIKGLIKGSKGYDDPVNRKKLVAGLAPIGSQLDFQKAGSGVRIERTDLLGNVGLKQDGSKRSGGAAGPSNTLPAPNKVIVTRRKVMLGRELECQNSNRLTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYI6</accession>
    <name>A0A0B1NYI6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative c2h2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002885">
        <property type="protein sequence ID" value="KHJ31442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYI6"/>
    <dbReference type="STRING" id="52586.A0A0B1NYI6"/>
    <dbReference type="HOGENOM" id="CLU_1273088_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="23825" checksum="CA9627D47795235A" modified="2015-03-04" version="1">MSYSQVSSSVPQNRMPPQAMRPMSHNGMHNMQGGMPSPYAPNNMLQMVDMKSPTHVVGSQGRRGILPSAPGRPPVNSNTAKSGLIATKDADGKFPCPHCTKTYLHAKHLKRHLLRHTGDRPYMCILCRDTFSRSDILKRHFQKCSIRRGNPTGASHLSHSQAHVKKAQLSTSKNINERIAEVNSSMAPPNEVIPMYRVAPDGAVPEQYSAACVSSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYJ2</accession>
    <name>A0A0B1NYJ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002878">
        <property type="protein sequence ID" value="KHJ31452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYJ2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYJ2"/>
    <dbReference type="HOGENOM" id="CLU_014533_0_0_1"/>
    <dbReference type="OMA" id="SPGNDWM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="619" mass="68399" checksum="12E932D193419D93" modified="2015-03-04" version="1">MTISGNLNEALVAGLELDDKKDCPDEDQSVSRNRSQRIRSISEIYLPALSPSSSSKESEKRIWRDDSIIDKPLNVPQSSSHLLHGLTLKMPPRELKNPSEFIPVSPNLEIFTTNMLPRHSRGMDFSRAATNLHHSTLADKSSPESSPIATGRAVSIHYKTNGFSVGNCGDFHHNISKIWPTSGGTDQMNLSSSLGSINMMMGSDSSDSCFDEDNLMDDIDDSILTTPHSKRFGDLNQDILKDNWLGQSISNFTPSNFKKNKRKSKKRNLNCESLNTTVGLITKQSANICNNNNSTQGLETLIDTGYQKRESKSWTTNKPHVSENESDEKASKNMLENIDSPPITPSREGQRGVIRRPVTRRGNMLPKTKGFARIQVALAEESAPIETEVMREAAVIRQTRESDIEYELRQPFGILPHTPILALSPHTSERSPKEIDKTALTSINQSEFKEKLLLRSKSKGPWATFGDDTMLSQNYPRTPASVVGSDIVLDSPLNSSMPPFSNESASPQPSLISRPATPQTGGRQIAVDITQKLSKKRLRDDDFDLCSIKRRAVSPGMSAHNSPIIKSPMQRDHTAWGSRPSSSSNFGEAGKSPVSTVQKRVGLQGMIDTNDSLMKMSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYM4</accession>
    <name>A0A0B1NYM4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Putative phosphoribosylformylglycinamidine cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g2287</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002854">
        <property type="protein sequence ID" value="KHJ31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYM4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYM4"/>
    <dbReference type="HOGENOM" id="CLU_005361_0_2_1"/>
    <dbReference type="OMA" id="EVMQACC"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="113"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="786" mass="84783" checksum="26BCC295B0040DEF" modified="2015-03-04" version="1">MHSMRVLIVGNGSREHAIAWKLSQSARVESIIVVPGNGGTEKCVKTTNVTTVRPDDYKALVALAQEKKINLVVPGPEAPLVDGIEGYFRAVGISCYGPSKEAARMEGSKTFSKDFMKRHNIPTARYKNFSNFDEAKKYLETVTYNVVIKASGLAGGKGVIIPNSKSEACTALEKIMLHEEFGSAGKEVVIEEFLEGEELSILTFSDGYSFKSLPPAQDHKRIFDGDQGPNTGGMGCYAPTKVATSDLIKEIERKILEPTISGMRNEKFPFRGTLFTGLMITKTGPKVLEYNVRFGDPETPTLLPLLSKETDLAEIMIACVEGWLSSVDLKVDSKFSATVVIAAGGYPGTYPKGKSIYIQPHTPNINLFHAGTTFREGQLQTSGGRVIAAQAISDTLGQAVETAYSGVKLVKFDDMFYRKDIAHRALDSSQPKIEALTYKSAGVNIDAGNDFVERIKKAVASTARPGSDAEIGGFGGELNLDQAGYKGAPILVGAIDGVGTKLMIAQAMQKHDSVGIDLVAMNVNDLIVQGAEPLMFLDYYGCSILNQDSAAAFIEGVAAGCREARCALVGGETAEMPDMYKPDEYDVAGAAIGVIQPGLRLPLKHEMIAGDLLIGIASVGIHSNGYSLVRRIVERESLLYDKDFAPWDNSKLIGDSLLTPTRIYVNSILQITNKKLIKGLSHITGGGLTENIPRMLPPHLSARVDIACWSQPPIFKWLQKTGGISSVEMARTFNNGIGMVVVVSPANLQNTISILEAAGEKVYEIGTLVARDGKDACILENINSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYU7</accession>
    <name>A0A0B1NYU7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003184">
        <property type="protein sequence ID" value="KHJ31158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYU7"/>
    <dbReference type="STRING" id="52586.A0A0B1NYU7"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23599" checksum="C505BB9CEF0F0793" modified="2015-03-04" version="1">MKPTIKDLAALNKRIQWQINNKNMGLKFVMLKQDSLRLVVFTDSSFANNPDYSSQIGFVIVLADTDGNCNIIQWSSIKCKRITRSVLASELYAMINGFDAACVLKHTIDTMNGKPIPLSLCVDSFSLYECLVKLGTTREKRLMIDISAIRQAYERREITEVIWIKGESNVADSMTKSVGNKALNRMIATNKLDLERKAWVERDDPKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ00</accession>
    <name>A0A0B1NZ00_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002711">
        <property type="protein sequence ID" value="KHJ31632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ00"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ00"/>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="OMA" id="QCKYINA"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="428" mass="48483" checksum="0949FB971A646BB4" modified="2015-03-04" version="1">MSENLDSEERLEGEPAVEILDGRIWVDGCWDFFHHGHAGAILQARKLGSELYVGVHSDKSILENKGPTVMTLEERIIAVNACKWVTRSISHAPYVTSLPWITHYGCKYVVHGDDITSDSDGQDCYRYVKAAGRFKVVKRTPSISTTDLVGRMLLCTRTHFIRNLNQLIQDTSHDEYEKSQNDGVNVKKLIQAYATDETGLNPSSSVWYWNICTDTREDNWKEQGDFIPLTQIIHPKPGQRAVYVDGSFDLFSSGHIEFLRLVVQNEEEISRKMGWYSEVEAQKRITSTGSDYAPVYVIAGIHNDETINHLKGLNYPIMNILERGLCVLQCKYINSAIFGAPIMLSHSFLSSIPFGTPCAVYHGPTNSNPPKVDPYLIPKEMGIYHEIKHHAYSAINASNICQRILRSRDLYEERQKLKALKSINEQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZJ6</accession>
    <name>A0A0B1NZJ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005143">
        <property type="protein sequence ID" value="KHJ30101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZJ6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZJ6"/>
    <dbReference type="HOGENOM" id="CLU_048612_1_0_1"/>
    <dbReference type="OMA" id="GSFGAHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="33233" checksum="6BD262D7F8A38723" modified="2015-03-04" version="1">MKRPAIDQLVYDYMFPKPRSTDPPNFQGLLQRQLVPEVRLETQAFYGHLKSQEAKYPGLDYSYQPHRARLSRYPWHRRLFRAFDNLGLTKSEIAGLTKWEGTRWAKERFEREQGIIIRDTTADGISDWVEPELRAPMAASVAKVSDKHESDKLDKVRVNSQIQEQTPERLGEQEEDHEVERETEARIEDDVDEESDLEIQSVGVALNERLRAVVAQREAGNPSMVIDEDWEQWYKEALESGGIPLLSSDNQLQARFSGPRQTSHTQTSSRLLSAGRLEHWHRTPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW3</accession>
    <name>A0A0B1NZW3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative rni-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002489">
        <property type="protein sequence ID" value="KHJ31907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW3"/>
    <dbReference type="HOGENOM" id="CLU_036208_0_0_1"/>
    <dbReference type="OMA" id="KWALLWR"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="558" mass="62872" checksum="A6F30EE6B2064B63" modified="2015-03-04" version="1">MLVLPPDILNLICEELGHQKDFQALFCCALAGKLMVRSALRWLYRIHSHSKIINSEGSDIENCNLTQAQVVQKWALLWRTIIRSSISDTAYPYCLYIRSLDLRNLADLLDDPSFRDYAMQMFFIDKMSRFLKFQKSQEVTTECAIAKISHLRLDIIKILELVGESVTTFIYKVATKSRATVAVEDLSGDIRADALIKWTSRLSKLKSITLWDGSVLNQETAKVIANGCFEFDDLTFYTCLNPKVDQELALFFRTLRPNSLRSFTALRANAVGSETFCSLCHHASSLRYLGLNGLKSDAIKKLSLLQDCKSIVSLKIEDSDGIIDLWESEKEVFEGIVKWLCGCRGLRELIIENLISAPEILTAVCLSNFVRLQRLQVIWYPLVNSHHFHRALAKQSSLEFLTLNATSEGAGRDDIDLLVSSISHLTKLKHLNILSTSDYFSTPAIVRLVSRLSKLEDLTFGGYDVTDDLWDAMANLPYLRALSIHAISSFSFEGILSYVDALHDTNEGLLLSVMSQSPDKPISEGEQSIIRQSLAANVCGIFDFTLYREPDSDIDFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P020</accession>
    <name>A0A0B1P020_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003840">
        <property type="protein sequence ID" value="KHJ30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P020"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10794" checksum="11C317627BFD6E5D" modified="2015-03-04" version="1">MAAAKCRNCGGLHRSDNRRCLARPSCFGAPTKEQMKPFRQVREREYQAVFRAKAAEESANSAENINNDLTCSQDPEVDGDIDNIPASPIGKSTGDAIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P040</accession>
    <name>A0A0B1P040_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative adp-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002742">
        <property type="protein sequence ID" value="KHJ31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P040"/>
    <dbReference type="STRING" id="52586.A0A0B1P040"/>
    <dbReference type="HOGENOM" id="CLU_062658_0_1_1"/>
    <dbReference type="OMA" id="NDPGLCN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="22978" checksum="33015A8D7C4238F0" modified="2015-03-04" version="1">MLTSVSKVLKTEILKSEDAKWIQLMLTTYRDPLGKERTWEYAERQTRPQSSSVDAVGIVAILDLPTGPEIVLQKQFRPPVNTVCIEIPAGLVDEGETPEQAAIRELKEETGYIGEISISTSIMLNDPGFCNTNLKMIHMTVDMNNPKNQNPQPELEENEFIEVFTLPLKSLFAQCEIWEREGFGLDARVATLAEGIELARKWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P059</accession>
    <name>A0A0B1P059_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002398">
        <property type="protein sequence ID" value="KHJ32022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P059"/>
    <dbReference type="HOGENOM" id="CLU_2639941_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="77" mass="8787" checksum="417F40CE70F9E808" modified="2015-03-04" version="1">MVTTRQISERAWHAPMMICTTAYEKDAAFKAYLRQAIAKFATVVIHPFPRKSQHILNRKICIIGFYFGDTSAPSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0F0</accession>
    <name>A0A0B1P0F0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative actin-related protein ro7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004385">
        <property type="protein sequence ID" value="KHJ30366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0F0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0F0"/>
    <dbReference type="HOGENOM" id="CLU_023246_0_0_1"/>
    <dbReference type="OMA" id="GDYRGWI"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="553" mass="61587" checksum="B66466C50C03B7F1" modified="2015-03-04" version="1">MTHRASSTARFSRTSTVGPQTPSRSQAINFGSPSVLRIEEECVIIELGSRFLRVGPAGCAFPQAITDFGPEQQRRAGDLRKWALDYDFSNRSGHNEKRWGKDYELWSLDLREVDLALVGDKIERALRESFTKTLLIDSRPRRILLAIPSLLPLPLLFTVLETIFSNFQPPSISLMPTSILTTVAAGLRSALVIDIGWAETSVTSVYELREVQCNRSIRASRTLGETVFNRINKIVTKCSSEGSPDDSKTQISFEECEEIIERMVWCKSIKQQAKNLDSGYLATLKEGEELNISIEGPCTTDEGEPDNIVSLPLNSIKPPKTIQIPFSEFSEPCEIALFANGIPESDIDDEELPLHLLAYKSLLKLPVDVRAMCMARIIFVGGSSQIPGLRTRIMQELSSLIETRGWNPVTGKTIKKNSMISSLQIHQKRSEETALQHETTNKSAKHASLRPQEIDSITEKLKREYLRTQPRAEMGKLRAVKSLGAWAGASLMSLMKIQPCSIIEKEQWAQNGASKFYTLGEPSLSSQRKSIGPGAIRSGVEEKSGWTLGIWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0M6</accession>
    <name>A0A0B1P0M6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003568">
        <property type="protein sequence ID" value="KHJ30815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0M6"/>
    <dbReference type="HOGENOM" id="CLU_010647_1_0_1"/>
    <dbReference type="OMA" id="QPANWYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="378"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="796" mass="89574" checksum="EF65F392B1CC49C5" modified="2015-03-04" version="1">MKTALHASNKCVFCAFREFEYGSRPFTFLNRNSGQKDSQKTLSNFRRLGRFFKENDENKNLAPSNPNSKTSEYRYRSRDFTSKSYWRNTDSTFNLFGELVLNELYTLQEKLKVDTSIDLAESWGIPSYEDLKEKISGFHQKVVDSINLASDGIVSKNSNPLFYRLRQAFVTGSIKALNLQVKFSFLSSIAPKSFSRDVQSKLEDLANLCHPDEWYPATRSLQRTVYLHVGPTNSGKTYHALQRLESVENGVYAGPLRLLAHEVYSRFNAKGKLCGLVTGEEKRIPPELKSNMYSCTVEMIPLNVPLDVAVIDEIQMIASPDRGWAWTQAFLGVQAKEVHLCGELRTVNIIKALCALVGDKLVIHKYQRLSPLELDSECVKADLSNLRKGDAVILFSRLAIHGMKQEIERVTGKRCAIVYGSLPPEIRAQQAALFNDPNNDYDFLVASDAVGMGLNLSIRRIIFETTQKFDGNERRVMETSEIKQIAGRAGRYKTGASDVYIDDSKASVSDITSSENIIDNNYDSKKKKSSTGLVTTLNQADFRTIKKCLSVEAPPITKVGISPPSEIVLRFASYFPPSTPFSYILLRLYEISSTLLPFTLCLPREEIAIADIIQPYDLSSRDRLTFTAAPISTHDPSMVSIIKELASCIASQSGGDLLRLKSFNLELLDININDHDTGSKGYLREAESLHKALTLYLWLSYRFAGVFTSQALAFHIKGLLEVKIDECLASATYYPDRRKEKNRTLKSKEQAMLEALLSSTDNEQEKLSSDFKIDSEKEDSLPFFGDEKALSLFLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P9</accession>
    <name>A0A0B1P0P9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01004121">
        <property type="protein sequence ID" value="KHJ30501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0P9"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="OMA" id="FRAGEIW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="202"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="692" mass="76734" checksum="5EBF8E8ADCFEAFD4" modified="2015-03-04" version="1">MDIFKILTRSTKIPRQNLINSGSETSLELPSAGTSINPQLFRGPELNSSGKKRKRWSEDVAEDSVPENNVDINFFASRSVVPEIKDETFGIKKPDQVQVMDESCCRKVLHSHKIKINILNSRKTSKKKSNKGKDLKPSAKKEYKQIYPQPLTKFSELKSLYGISNRLAENLAKQGYKIPTEVQMASLPLLLRPEIALKQSSDSLNGSDMNLLVVAPTGSGKTLAFLIPIIDQILQRRRKSENKAAHILEALVVAPTKELADQILYEAKILSEGTGVKVSGMRKGLKVVDEDITPQNTPGCAENQTKTLVPKQSITKADILVTTPGILLNSLKNNSTSTSLCLPSVRTLVLDEADILLDPLFYEQTSSIWAALTCPNLRTTLWSATISSSVENIALSTIRNRFTKNPPLIRIVVGLKDSALPTISHTLSYCGTETGKILALRSLLHTSSGEINTPKALRPPIIIFTQTIPRATALYDELLYDIPPQAGGSSRLAVLHSSLSDKARLTTLNRFRSGEVWILITTDILSRGVDFRGVNAVINYDIPNDAASYIHRVGRTGRCGRKGGTAVTFYTREDIPFIRGVVNVIEASNKASGICTNNGNGKGNTWLLDILPKLDKTDKKKLKLRGVEARRNDIANINNGTEERQSRKQKIRHSSTRISTRSGYERRLRNRKRDAIRASKIKRQKEMQEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0R6</accession>
    <name>A0A0B1P0R6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative c2h2 type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003496">
        <property type="protein sequence ID" value="KHJ30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0R6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0R6"/>
    <dbReference type="HOGENOM" id="CLU_014490_0_0_1"/>
    <dbReference type="OMA" id="SFQGHRR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="666" mass="74856" checksum="5FADF49E664346A5" modified="2015-03-04" version="1">MESRYSLWSTGYLESNSNRRHIWTPQKNTDTSEIVPSLGGSFLNSSQNSIKNNISSFQNSSTPFIGNSISPDYKLQSDLDQQFHKQENSLQFTPTVESKKNIGEDLLVVNPQNNLQANISLTPISCTSEQYDPKIYLDKTQKNNTNGLTHGMNSPQGHSFISSLSYLQPDMGSNPSGQQTLNLNQACFNTTSNNNRNTSLSSVNTGHFGRPFDFDLMLGQFHGHRRTPSEYSDVSATSLQHSPNLAQQNFLDQQNSPIQVAQDPASYQDVLAIGKFSLSDPQISCAQSTRSPSHSPAISPRLNPEQLLKGPQLADGGVDRFCHDYDFFPQEVFPPLQNEMGQALQMKPPEINVEFVSMPKQNSFEASKPNLLDQNALTPTDKVRRRAFTDTYKSNSELFSRPRNSSCFSPRFGPKLSTHSHDTLNSLSPNAISRNNSPNRLRRQSSPVMPSRDNQSYISNSAPQSLAIEKTKLERVQKHPATYQCHLCPKKFTRAYNLRSHLRTHTNERPFICSKCTKAFARQHDRKRHESLHSGEKRFICRGELKNGGHWGCGRPFARADALNRHFRSEAGRACINPLIEEDESENLRLWNEKQIQNIKQTQSHVAISSEMDVALNRFTLPAALLAQYPALTPYSWTDLPQGNSVIEDDLSGRSSFDASGSEHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0X7</accession>
    <name>A0A0B1P0X7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004162">
        <property type="protein sequence ID" value="KHJ30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0X7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0X7"/>
    <dbReference type="HOGENOM" id="CLU_597152_0_0_1"/>
    <dbReference type="OMA" id="ESGHELY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="337"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="49261" checksum="E1D8E2CB351DC266" modified="2015-03-04" version="1">MLPSLPSFTKFEYSHNASKLPYRTCASSEHHEQLPSIFELVPELSKESPRDFHLAFRRESEPRCYEPRNYQVLNTCAPLSSSNCHQSKRRRLSVDEDEDMRRLREVEDFRSRDKHFSGPWSYFQQTNAPTPDPSPSSRRSSTFSSNETWTESPPSNRFTNISSQTADNESSPFSRTETQSRPDSHRGLGNNSSPNFSLHKDPLEVNVANGSHLQDRYLHRLSTLNLAHLPQRPSCSSRTDKECYHDMPVSMAHSSLPNSELPYSSDSKMNSFRGYLNSDTVTYTASSQASNQFSKDGLDHKAAAREYSIFQGESGHELYAENVSHFNSDDVVGARENKPRKRRGNLPKDTTDKLRTWFLNHLEHPYPTEDEKQQLMDSTGLQMNQISNWYINARRRQLPAITANARAEAEARRHIQRSPNTPKSKKCEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C0</accession>
    <name>A0A0B1P1C0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003732">
        <property type="protein sequence ID" value="KHJ30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="178" mass="19819" checksum="36B2733EA4ADCAA7" modified="2015-03-04" version="1">MRPSFLKLYGRNVLEAPHRTWMAFFTKAPRPGFRVFDESGVMRNFKKQQSPEFCKRCNGHHPPKNCSRAPSCGNCGSTMHSEDLCMAQTRCKNCGGPHRSDSKKCLARPTRSGLPSKEQLKTYRQAGEREYQAILRANAAEKMATTAESESSNIASSKSSEITDASPIEATIVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F0</accession>
    <name>A0A0B1P1F0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dna polymerase epsilon subunit c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003815">
        <property type="protein sequence ID" value="KHJ30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1F0"/>
    <dbReference type="HOGENOM" id="CLU_004692_0_0_1"/>
    <dbReference type="OMA" id="DHAQEFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="105284" checksum="481548DAB4103857" modified="2015-03-04" version="1">MDFWSRLIAGIPLASTDKTTSKNPDKRLASFKKEYFQLLSHISLGISNLLANYESVETIRTSLQELTSILSDESRRPLPHPCISFASSEKIYVQIEKIAILSRNEGIIRESVAIFATLIESEEEDFVENHIFSRSLMKLLVQITGTNSIRLGLDTEVEVVELAFNITTKIRLDPDILPAWFASQSHNKISEKEIGLSEKFTGKTHKEDFPLFYLLIDYIHHEGRIGDFARTGLLYIIEAASNSINLEQWIVESDLATLMATGLGALYSQLSRKLVIDYPDEELAPVLALSDYQHPITSSEIVSSSSSEFQLQIETFLSHLVFWQDVLNHCKSSEINQTLLEHFRVIFLQQLLYPSLLESSDLDGGSSVAVLTYLRRILEALDHPDMIHLILHYLLALPDSAPSSSNTRASMSAARQRKSVDLATLMASQVEVKPSPALYNLVDLIHGSLTSPKKETISVTLQLLSVILKKHHRYAVTTLFRTSQILSCRPPRTIGAHNGMMHFLLGLAGQIGGERNVLDEIYHNHVKDCMNILECHSCSVTMIYPQSASNLPKITGAHATIPGAPRDVRLHTLRVDDPMLQIIIEMMSIFLVNSIEINLSLTANIVDLATCGYMRIDGWLLPDLSNHIYEQDSSITESISKPILTDPMEAQEEAQIRSLKLARQIPRWTESQIPALLSVLNKVVEQVNVYKTEIPRFDELIQQRRQAFITASISNPTPSISHKNINKSSADLNAESSPRPSSALDNLAQRIFPERTSPMRSKSPMGRMNQDRGNKLVANFESNSSSLSRSNSLTPRPSISREKLHNRISGVYSSSHIEKAETQPGHSKASINQIEAFLTQDQSIMTRKVILPVPDRKTVFLESRNLEDEEKKYTIDQSEIHQHNLDDNTNSNLEEKTSQKFVSVNHLLTNVIIVQDFLLELAALVQVRASLFGEVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H8</accession>
    <name>A0A0B1P1H8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003209">
        <property type="protein sequence ID" value="KHJ31145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1H8"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_25_1"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="586" mass="65335" checksum="CCABE5ABD9184990" modified="2015-03-04" version="1">MISEGESSNNNETPRTFINGSGTNNFYKPTVSNPMSIAKQSLTTMNGPTVKNGNNVDKLKTSYFGHDREEVTRILQQALLDLGYEKSALVLREESGFELESPAVAEFRNAVIQGDWAHAEELLLGGSAGQSGLGLALRNGVDMSGMRFWLRQQKYLELLEKRETGSALMVLRLELTPLYQDTGKLHFLSSLLMCQSADDLKAKAEWDGAAGNSRYNLLSDLCKCVSPSVILPEHRLAVLLQQVKNHQIASCLYHNTASSPSLYQDHTCDRTQFPSHSVIELDRHSGEVWQVKFSNDGTKLASCGEDGTCIIYEVGTFDLLQTLITSELGICSIAWSPDDSLIVTCANDKHATLWNSSTGVSRRKLPKFGEPVSSCVWAPDGQSFVTGCLDKERNLCQWNLNGQLVYDWGRTHRVQDLAVSNNGHYLVALDNETKIYVYNFVTRELEYQLDLKYKMGSVSISQNSRQLLVNKLNGEIRMIDLDTRQTIREFKSGEDGGHYVIRSSFGGANESFVVVGSEEGYIYIWHKESGKLIEKLEGHRKGCCTAVSWSPVDPCMFATAGDDTKVRIWANLDKFPTRTDELSINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P230</accession>
    <name>A0A0B1P230_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5739</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002200">
        <property type="protein sequence ID" value="KHJ32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P230"/>
    <dbReference type="STRING" id="52586.A0A0B1P230"/>
    <dbReference type="HOGENOM" id="CLU_004312_0_2_1"/>
    <dbReference type="OMA" id="FATAYNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052811">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902635">
        <property type="term" value="P:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="324"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="760" mass="86124" checksum="8490C4C946B1933C" modified="2015-03-04" version="1">MFPLQLPNAVEIQYFDPGPLFTSSRPSFDIPSYPRHSRKKANGSNTSSTNINIVRKGSYGNDIDENPLEILNKKPHVEVNTTPDVTIGSNSNIKTHSGSVFPCSPSVSIDLANIREIKVNGSDQISTSRKDPAISTSSDIEVSDFVDMEIKMKCEEEASKRSSKVSLPVYTDSRSTGSSNIPTHQSTASSAPTTNYRSSFPSTHPPKIEPVTSLVSTQSLKSHTPNEPRCRNTLQVPKVATTRTSADETTSTSGRFTPTLTSTSIRRSSFNHTARSPHPPNTAMPHEELPPDDNAMLWAEVVRQRRASKRRRKDDEDEDRVIVGTKVDQNHVNWVTAYNMLTGIRFTVSRTNAKIDRPLTDADFEARHKFSFDITGNELTPSAKYDFKFKDYAPWVFRHLRSKFKLDPADYLMSLTSKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHAEHKFLRKILKEYFAHVEANPNTLLSQFYGLHRVKMPYGRKIHFVVMNNLFPPHRDIHQTFDLKGSIIGRDYNEENLATNPRATLKDVNWLRRNLHLEFGPEKRKLFFEQMEKDVSLLQKLGIMDYSMLVGIHNLQIGNQENLRDKTLQVFQPGGDNPSEETDRGVDGRGALLRTPSKLENARKARELRQIIKQEKPIPMGQSSSRMPDTLEPNTSKKELLFYGDDGGFQATHEDNSPGDQIFFLSIIDCLTHYGTIKKLEHFIKGIKYDKRLISPVSPDPYGERFVQFIEGITKSPEEASKEASNIQSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P250</accession>
    <name>A0A0B1P250_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002175">
        <property type="protein sequence ID" value="KHJ32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P250"/>
    <dbReference type="SMR" id="A0A0B1P250"/>
    <dbReference type="STRING" id="52586.A0A0B1P250"/>
    <dbReference type="HOGENOM" id="CLU_018273_1_0_1"/>
    <dbReference type="OMA" id="YNGNHRP"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="420"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="58290" checksum="FBB6CA5747265218" modified="2015-03-04" version="1">MGQIRKKTATRGAEGGVKYVCDVCSADITSTVRIRCADPHCHDYDLCVLCFSNGEASHNHNPGTHPYRVIEQNSVPIYDRNWGADEELLLLEGAEIYGFGSWADIADHIGGYRDKDEVKAHYQKVYLDSPKFPLPVRASLKDTQLLEEIPREEFQARKKRRIEERKEAARLAPPTIPKTKPTASVPACHEVQGYMPGRLEFETEYANEAEEAVQLMQFDPGDGINPRTGELEPEMELKLTVMDIYNTRLTQRAERKKVIFEHNLLDYKKNSALDKKRTKEERELLNKAKPFARMMNRDDFQEFCSGLLEEYHLRLAINQLFEWRSMRIDDLRAGEKYEQEKVQRAQRSQPMGSLDRERFTSSQRGKPAASVETHSVVASYISPDLPIYQNPNILIEGKILTNGMGNCFNSSTRNKYHVLPIQSVQPISFEDGKFPDSHLLLPEEIELCEKTRIHPKPYLAIKENILREAIQTNGMLKRRQVKELAKVDPQKGARIFDFFIAHGWLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P299</accession>
    <name>A0A0B1P299_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002105">
        <property type="protein sequence ID" value="KHJ32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P299"/>
    <dbReference type="STRING" id="52586.A0A0B1P299"/>
    <dbReference type="HOGENOM" id="CLU_130032_0_1_1"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="143" mass="16770" checksum="B281D6716A4FCBDD" modified="2015-03-04" version="1">MTSILRSTRIQPRMLSKEEEARTDEVEVRREDQDKINKFSRLHHKEISLGEQLNLKLKEKEELDDVSNELELNDEDDKILYKIGDCFVSLQLREVQELLEASTTKVRNEINQLEEKLSAIRGEMSDLKIHLYARFGPSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X5</accession>
    <name>A0A0B1P2X5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mob1 phocein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001935">
        <property type="protein sequence ID" value="KHJ32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X5"/>
    <dbReference type="HOGENOM" id="CLU_038321_0_1_1"/>
    <dbReference type="OMA" id="VSYAHNP"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="39827" checksum="738056E03A8E251E" modified="2015-03-04" version="1">MSNLFSGISGRFRGSGKNGGSKSPGLSSPTSPTENSHNGAMSNIPPRVPQLPNSPLLSQNFSIEDNNFGQLNGDLLSHYNLPRPRPLWINDAYAKHIVKGNFMTLSTRPKTVEQGEWIAHQVVEHYRNLWNFVGVIHDKDEDGTSICNSSTCPRMSAGANFSFTWLNPRKEPVEVPAHEYISLMQRWISGKIDNTAIFPTDPNTVLYAPPPGNSNHAHSNLNISNSNSSIKPGSFNSYAHMGNPTDWIGKASGFPMEFFEVCQTIFRQMFRVYAHLYWSHFVDPFYHLSLEKSMNSCFSHFILTATEIDMLKPYELEPMQPLIDLWAANGTFPKESKAYAGANVKAGERLISLSGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P364</accession>
    <name>A0A0B1P364_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003244">
        <property type="protein sequence ID" value="KHJ31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P364"/>
    <dbReference type="STRING" id="52586.A0A0B1P364"/>
    <dbReference type="HOGENOM" id="CLU_077999_0_0_1"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="234" mass="26649" checksum="383D888ADEA71326" modified="2015-03-04" version="1">MTTDTEPNSHSTHADKEENRRDLKHRRSRSPSNEKRPRRNHNVSHGFRWKDKQQNERRDYIDTSESNRKRLERGYRDRSQTRRSRDSEIQTSKSAVGGIEDKYNVANKFGPSSTSTRGGSRRKQDNYEKEDESPSGQSLNSTAKALATTTTANDTEPMIVVYVNDRLGTRAAIPCLASDSILLFKAQVAARIGRQPHEIMLKRQGERPFKNQLTLEDYGVSNGVQLDLEVDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P383</accession>
    <name>A0A0B1P383_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative involucrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003217">
        <property type="protein sequence ID" value="KHJ31139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P383"/>
    <dbReference type="HOGENOM" id="CLU_227859_0_0_1"/>
    <dbReference type="OMA" id="EDINITX"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="896"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2051"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2174"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2232"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2051"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2068"/>
            <end position="2078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2607" mass="296327" checksum="3F356E917D34132B" modified="2015-03-04" version="1">MAEKELEEAAEKDLDGMVKNEINLKILETSRQSRLKGSSMQITTTDKKKKMKDRNISNSVLADSLSTQVDTDIEIQDKIFVAPEPKANMTRLCVVNKEEKFPQVINHLIDENKEISHGKYEEQFQLADKKFVENKEKDIKIKMEENSSINVLTKNNATITKKLGNKKKKKRNSLDTALIDTLRVQVDDGKGIFNAISENVEFSLPELNYDLESVNQFSNVKKIGKLEKEKTIIDHGVMEKSSEDNQTESSIIVDTNSNVKTKILEKEKSLDSSLPEASSTRNLYKNEQVSSTYELVSPMSNDIVEPKEELLNEMINTQNFQREKACEEKLNIKVEIEKKIKDRKQVEKKVVHKISENFHEVSQLEGSSIPVSSSGKKKKKKKKNNKRLDSALSDLQSTQVNNDIKGNDDLHEAAEPTTSETKINVVDIDEFSSKVVNQPKDKLNDENEFQNKNQETAKPGDVKESRNENEKKNTILEVSHQDKQLEDSPILISKSGKKKKKRKNQNSLDSVPIDVLSTQLVSESKIHDAQHKILNYLTPELELNTSSQENQFGDLADRQQVMNEGERRREKCGDEEKSRNEEKKYKVVNKNELEHKLVEINFSDDLSERTISLNTKLDKKMNRNILDTTMIEITHEESDDGKENLNTIPKRPLSSLKDSEQSSTKDNENENRKEHERGVDKKNNIEDKKVATEGVNFMIPTKTHYDQLDDSHGSEISTKRNSQESLGTAIIKSLSVIDNDTDKEFNESSSVRLSISKSENSGETIPMNLNEERSLSNCVKELEKLSEEHIQEMVLENTRYDEQLKNSSTLVTNLDRKKKREKNQIISDKSMTDKSRSQVNTGLNNKIISESARLLTPKIKFNEGVIDKKMVEKEGGKYNQKENEDVESRDLEIYQQESQLEDSSISVSSSGKKKKNDKRSELALANSQSTQVDDDNKVHNDMSQATEPTASETKINFVDKEVHLAKLVGRPNLAENDGMKDKLEIEKKTNPEISEKSHLQEEFEISTTLATNLDKKEKSNKILSVESSVSKNLSKLDGPSTFETIVYEKTNQKFLNDENLKIEKNESKEESKVSGEKNPEYEIIQLFNIGVDDKSVEETEPMTSEKNLDDQREISDTYESFSSVIQNMKMNFNKVSDLAFISTEPEKLVNQDKSLLNQYQTIKSSLSEDNYNDKVAERFGSEIEGGKEAKQINWNLSQENYTQPGNSFILGHTLSEIEINEEKTQNRPVEITDDPTTLDAINKSEKIEYLTNTPLPSDAKLILYSGPKKSNLIDKVKEKISGKGNLAGNEIDDMLENKPKLVAPEYSNIDIQDRTDSMVSNNQSIFITDRVKNYDELSLPRLKNGGRLDEKLLEDRLGLKTPSIDEKTDIQLIKNLDTSQNKNPMAMTVVENYSSSSPEILDEVDEIKNRTRSVFNSKPNPDVKKKISESLFSELKSEEFFGNTASASFQRNYQVNTSELVLTLDKKTRVIENWSNLDLSVSNQNDPIKKEEKKSDAEKEISIEVKCENPKIFLMELPDSTYGDNSSSVSFSLEKVESKGNMKTPDLAEGLEKVEDILMPHPESLISKLGTDNPDYWGNPVQLSNKFGKIPESNAPYDSSLEPISIPENIQFPLQDTTKVRNLLSNYHDNHFSTLRGDNEENEKLPIDFSVPLKDSITGRSTFTREAEVNQVREVDNLTNENTKALVDMKNKATLGIEFTNDANVLNGSKLLIKDKYNEHTFNGKNRVHNSLLSTTYNQKNEYLSEKIHLTLPTNDEDCPRIENLSNLSYFKNSQKSSTKDNLELSSSSSSKSIDSDIQLLTSIPCKNSLSGSSSSINNSSLNILEENDQSVTQKSTKFLSDPLGEFHALPLRSKRSSHFRFSKLPIVSEERQLENAEQNDRPLYQANKNDVSHCRLKKEISNLEIQNTKSNTITSKSDVLKENTNTSTALSNENPRIYEKSKLRNYRSFQIINKEKSMDIRRSLSYSSNLSNKGIVQECIRKFESSEDIHIPPKVGREGVEIPRSQMSAREVYAALKSSDPCAKKPSKAEIGISKTVADIPIKDIPTVLESNFEQQPSDVKSRRSTLKITNSPSKDSQISDHEISSHPLRRSKPDTSGDLRSLSQHKEKLGSQTLNPSQDKHKTSNAAPQPNEGRVRAKDMADIFDGVGEGHLISARSPTRPHSLRRRQSMKVLDLESKVENLVEQNRALIEEKQNIEQQIKLSEVSKLTEVNESLNCAASAITQQYSDRNAILESEHASLSQELEQIRISHQKLTRDFQNEVESKISLKDLEISELRTELDAAKQKIRESQKQILLLKESDLEYLHLRHEDYFERACQKLCQHVQQWVLRFSKYSDMKSCRLTSEIKDDKIVERLDNAILDGSDVDAYLLDRVKRRDVFMSMVITMIWEYIFTRYLFGMGRDQRQKLKLLEKSLFEVGPASAVHSWRAITLTLLSKRTVFVQQKEQDTQAVVDVIISVLSEILPPPSNFERQIQEQLSRVMNEAVDLSIEMRCQKAEYMMLPPLQPEYDNNGEVLSKVLFKAAVMNERSGDTLSNEELEAQKAIVRIVLFPLVVKRGDDSGHTKQETVICPAQVLIAKPKSLIHREDEVRSKISMKSNSLTLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3E3</accession>
    <name>A0A0B1P3E3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative duf6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003139">
        <property type="protein sequence ID" value="KHJ31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3E3"/>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="OMA" id="KYSLWDA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="207"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="41535" checksum="4F87873169A23492" modified="2015-03-04" version="1">MPEQDTIIRSNDSKESGTCKWKRIWMNNRGAFLILIAEAFASAMDAIARYLQQGEHGMHTFQIIFARMSGTFIISFIYLWWKRLPNFPLSNPSVRPLLILRSLFGFCGVFCIYYSVHYLPLAEATIFRFLVPLLTAFTCSILLHQPFTRKDLMLSILALVGIVIIAHPASIMGRASSIEGVVYNPVSKVVSIYLSHADATTPIQRVIAVVMATIGVIGGAGSYTTIRFIGERAHALHLMIYYSFLCTFCSAFFLLVVPGISFVKPQGLDWVMLLLLGLLGFAVQFLLTKGLQLDHSNKATSMLYSQVIYAILFDWVIWRVLPDKWGCIGGAIVIGSTLWSALTKPSVHSQKELTVSETPDEERPLLGDTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P407</accession>
    <name>A0A0B1P407_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001454">
        <property type="protein sequence ID" value="KHJ33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P407"/>
    <dbReference type="STRING" id="52586.A0A0B1P407"/>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="348" mass="38828" checksum="D27D8325F74039B3" modified="2015-03-04" version="1">MMRRLIIISSSLSMRLNLTISRKYATEASRPSTSLKVFNRHIKNLQRERAASYKDQSRQVDYLKDEVALRLVGRLHDIKRQFPHILDFGANSCNIARALTQKNPYSNPGDSLLSTKILRITAAESSGKLLNRDADLPFNKEIHLCREIIDMENLPYNPNSFDAVLSSMSMHWINELPSVLSQINNILKPDAPFLAAMLGGDTLFELRTSLQLADQERRGGISPHISPLADVRDMGGLLQKAGFKMLTVDVDDIIVDFPDTFSLMQDLQAMGENNAIILREAGAIKRDVLLANEGIYKELYGNEDGTIPATFRMIYMIGWKEGPNQAKPLPRGSADINIKDILGGGSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4M8</accession>
    <name>A0A0B1P4M8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycerol-3-phosphate o-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4M8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4M8"/>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="772" mass="86971" checksum="5271BFC11C9D200F" modified="2015-03-04" version="1">MADSYGTREQMPAFKLRHLERHPMTNWIYDFFLWVFSIMIDLFFREVHPRGSWKVPRKGPIILVAAPHANQFVDPLILMKTLRTDCRRRASFLIAAKSMDKWLIGWFARKVGAMPVARALDMVRAADGTIYMPEPDDDPLLIRGFGTKFGTNQAKVGDLLVLPTVHGIAANAEIGEIISFEELRLKKPFRDRAAITQLTQKIDCEDSGVEKLADSSGTVFKGSSYKIAPKVDQTKVYDAVFDRLRSGGAVGIFPEGGSHDRTELLPLKAGVAIMALGALAADPDSNLKIIPCGLNYFHAHKFRSRAVVEFGNPIDIPKELVELYRNGERREAVGKLLETVYQSLVAVTVTSPDYDTLMLIQAARRLYNPTGRHLPLPMVVELNRRLVKGYKHYKNDPRVVSLQKAVLNYNKQLRYLNIKDHQVEYAKHSIPKIITLLLYRLGKISILSIGVLPGLVLFSPVFVASKVISIKKSREALASSTVKLQGRDVVATWKLLVALIFTPILYNVYTFMLTYWTYRNRIQGYVPQWVPLTAVVLFGYIIFTAITFAALRFGEVGMDIFKSLRPLLLSLHPASSNSIRKLKERREKLSAQVTNVINTLGPEVFPDFDASRIVADPFVFEGSSPTIPTRMESNRRGSDHSSISEMEWPGIYKISTDYVMNRMNGNLPRSESLSNLGNISLFATRPPSRSRSRSSSRGEAISCEAYPLQSLSTLNSASGLEVVSSKIRDAMRERGLLRRKTIEGLRSEDVRDEYYQFCEKETGIENDERIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P514</accession>
    <name>A0A0B1P514_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P514"/>
    <dbReference type="HOGENOM" id="CLU_151460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="12723" checksum="6A8DA8391BE065B8" modified="2015-03-04" version="1">MDHKIELPVKSKSSPSRGAGLNAQYALHVWYSQEDSHSHSLQNPPFITAGLNRLRFYITFSSAPFFFHEAPHDWPREYRVKSSILSQRTSDESKLLAQMVGCWLDFLEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P574</accession>
    <name>A0A0B1P574_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative elmo ced-12 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002028">
        <property type="protein sequence ID" value="KHJ32505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P574"/>
    <dbReference type="STRING" id="52586.A0A0B1P574"/>
    <dbReference type="HOGENOM" id="CLU_009191_0_0_1"/>
    <dbReference type="OMA" id="CPHMKDL"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="257"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="724" mass="82195" checksum="8D1B7D67CF2AF284" modified="2015-03-04" version="1">MNQADIPELLTKLQSGEDAIRKLAIFKLQTSINDPSIADVFISTGGLQVLRQLIMTTSGNTLAYALSALSRLLEVEMGWEIFESNGAEALVERLVGLIVTHPLVNILRGAMSILVAVVGHSQNSKESSQVPGIFGFRALKPAIAVYPQFFEMVVSQLKSADHLLCSNALMLLNALIRDVITRAESTEKNSGESSKPHENWPELIKKLQDLGIVQTAYDLMQSSSHQDMAYSLLEFQAVSKLILKKRRETVVNIENLEHQSMLEKIYSSSQKKNKKEVQSTIKNTQQSSINGKTNSNEQNLEMWRNLGFQTESPILEFEQTGVLGMMDLVHFATSNEESYQKYLQEQETRPFNERCPIGRASMSVTGILYDHFDIERSDPEYIKDYRAIDGMKNYADLFRPFILQWPRIHVKALNSFIVLWKQVGAEKQEFGKVVELLRILVDKVLRGVSRTKDIQEIEEELTGLDARQLRKIQMEILNTAFEDEWEQHLFQIREELRNEALQFMKEQRIRTLLNGAWFPRTEINVDVVGAQDEHTHSLSWRYVRLSNDRRYLHYDDFESQATNEPSINNLSQKIDLENISSVASNTSACSNEDSSICTSTTAATARPSEAQTKATGITIRCFVSIKDSKQRNLDTSNEMVKEKTALILMPANKNLASSWLDGLLMLLDQAPITPETIKLVDFICDYGLKIRLLNVRMDDFLDPPDGAGVIPSREGLDEDYFYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F2</accession>
    <name>A0A0B1P5F2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001386">
        <property type="protein sequence ID" value="KHJ33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5F2"/>
    <dbReference type="HOGENOM" id="CLU_303512_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="981" mass="112544" checksum="0B4CC4E10AB8EE91" modified="2015-03-04" version="1">MVIISPKQADSVSDNDSISLTSTIGSAHSENEFFEVKKILAENPNSKTATFLIQWEGYPVSRATWEPRKQIRHLRSVINEWRQTQKLEQSGIQESFDTAAWAAAREKSEDERQSRKVRRAIKRKRLQKATKKELDWDLDFKSCVKTEKSENGLMTTDDIPENTIKKEPEEKNLVNLLPKSNRNRRKIISDDDEDNDTTETPETTDFHTRDIIPTNLQKSESPVDSFFQARPLNSTEPVIEVCLSPPMRMDQNNELKDYASNPNLEYSSNVIEEPEYPQEDVLEQKVNQNQNDSVKEVVLGADNSSFISLDFGNIQMISENYLKDTIMATKKIHFNQLCIAQDFQSQYCSIKSPVIWQESFTSVDPNDRDTTKKIEIVFNELVIRCAGLLAVVNKFIILMFPVRREEWRFIDQSPEISAEFRLRYSIFSNNFRDKLPIHTETSYEMVSRSPSLFGESRKLLIMKLLDRLIPRYENCQSTCKYFLLFPPSASKMANFVKFCLISYHPNIKVYGSMTEGSWDTFNQTQTLSTASHTTENETLRVVLIHESAITELFRIPNLSIILNNTKTTFWQFSDGSSKHSLYPSFYSPPNLQLGNITATELYPHGCAVFLTPSFLVAEPKSAINFIRWFVAEKIQKHIVPCRFVGAHNLPSFVLDVAKSKASEASSYEKRHAKNPKKKEVLKERFLDYQTCKIRWGLYNELFKLSQYYLNNSGCQKTFESVLLQAPSMINPDNEHELIRWFAAWSLINSDIFRKFLVIGTGLSSTPHAKYLKECPVKNRDSISKLKKQTPKTSSFIPDEVEGLKKGTLDRNLSITLNTQNTKPLSEGASKGVNLSLTNKSLETRISEASRDLSETMNSNPNYLRNTSSNLNTLEPELGFRTMNTPLLGATQNPGSKPFDSEPIVHNRKEKDNLNENLIHKLPVTSKVEEDNKAAHKPAIELKELKFEATTEWYKRLRARGSGWEHVTVTEFSEARKLLEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G2</accession>
    <name>A0A0B1P5G2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002505">
        <property type="protein sequence ID" value="KHJ31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G2"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="39149" checksum="BB9DC621A8B4DBA2" modified="2015-03-04" version="1">MGKSCSSDGNQQRTTPPIPIPNSPPLIASPSPPSNLETPSKTVDSRQILKPVAPSKGPVTGRPTQNNRDKPEIENAFLPKELADIIAIRQRRERAWDARLQICTNMISSIDSTLANFKEEVEIEEIVAFKTFRRQIIANFAADPSSSPPLIPSHTRPNKGNGNSNHKDKDKNLKKVLVATPYIVPTPVLNRKKTQEASLPKNPPTNNNIWVTVARNGHIKARVVSPTNKTATSGADKRLFVWVTQEHEGRKLSPAGIREVLVRKLSISPTLIGRIKPVHSGFALSLCCVEAREAILNAGNSLFLTGAKLESATNWVPVIIPTVPSTIRNEQGDVEVSSSMLADEIERVCSVQPAHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5H2</accession>
    <name>A0A0B1P5H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative translocon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002267">
        <property type="protein sequence ID" value="KHJ32176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5H2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5H2"/>
    <dbReference type="HOGENOM" id="CLU_133423_0_0_1"/>
    <dbReference type="OMA" id="MNESPEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="17186" checksum="84886FBA8405737D" modified="2015-03-04" version="1">MNESPEGKDCANLLGYPRHAELTGRLDRHRVKVKISTLPALLSALANEIKSPESSPRPSSPANAAARIVTTGRQASPMPPGGPKTAIRRRAAADQRDKAANARPSSTRAAGAGGSSSTMLRLYTDESPGLKVDPVVVLVLSLVFIFSVVALHVIAKITRKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5K2</accession>
    <name>A0A0B1P5K2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5K2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5K2"/>
    <dbReference type="HOGENOM" id="CLU_738090_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="137"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="40653" checksum="0C6817E3F2CDF267" modified="2015-03-04" version="1">MYQLYYKKKRQSEKACRIKDSEKRNFGTSGMNYKENPEIPRKNSSYSNPKVGLSITPSEKCASQDSHRANPFGKHAEVLADPVNSSRPNNIGKAVSEQSRLTHGSMKNLSSSSSPSAPAMQPNTNPSNTEFQNSFRPSSAVYRVQMDFTPSMNDELELRSGQLIRVLHEFDDGWAMCIRLDCSEQGVCPRTCLSTRPLKPRSPSASSSIRPGTQMMQGNQNSKEFAPLPMLPIAQLGSGQRSPPVSSPGNITVKSNDVAITSKNKGNETQSPTVCHEQQLPSVIPLKNAARYVSLTLPKFDGPVPHSIPELSGSPAPVDDYFSFSKPTVESVIKDVDNGQTPSPSSPSIGGGIGIPAEFLVQKPTPLKPVPGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P603</accession>
    <name>A0A0B1P603_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative upf0326 protein hag1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P603"/>
    <dbReference type="STRING" id="52586.A0A0B1P603"/>
    <dbReference type="HOGENOM" id="CLU_069001_2_0_1"/>
    <dbReference type="OMA" id="VYWTKPG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="237" mass="26209" checksum="E4B028CE15F55681" modified="2015-03-04" version="1">MNCTKINEDSSSTNQKLTTDYQRIKIAINIYDLLPPGKLSSILWACGSALLHSGVVINDREYAYGGHDSKGVTGIYYTPPRTVPPGGNFRCEILHGFTFQSLVEIDSIIKEASEVFQGTSYNILTMNCNHFTSFLLEKLTNRPGPSWLNRAASIGLALPCVVPKEWISPPDFETVNGDLVNNGDDDDDDDDDDDGIGHERTRMLGSTDNCSRISVDKNLNQKKHKIRVSQKGTKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P628</accession>
    <name>A0A0B1P628_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002311">
        <property type="protein sequence ID" value="KHJ32134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P628"/>
    <dbReference type="STRING" id="52586.A0A0B1P628"/>
    <dbReference type="HOGENOM" id="CLU_000384_20_1_1"/>
    <dbReference type="OMA" id="RIRYIRA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="41168" checksum="81F18E1618DC6666" modified="2015-03-04" version="1">MVGLNDVDMETEGSQYYQTPDSQPSTSNINESAPSWASQILRLLTQLIGIQSSTRQPPCDQKPGHSQPHPEKFSGFDPTLYPQFRSLLEAKLQIDAEAIGSEAEKVWYGFGRLTDTASRRIHPWIEFAKNTERFTVEEFLNRLDKAVGDSDKITKAINKLNTIKQGNRDFREFLQDFEQTILEAQGWGWDDQIKKGYLRTAINRELSDRLVSQDEPVGYEDFVSQLRRTFDKMEVIKTWSDRKNRSRGLIPQSTQTISNEPNGDPMDWEPTQTINIANTQRNLMRQTQPERATWVSREEIGRRIEAGLCLRCGGRGHMIRDCPLLPAYNPNRQGKNMSFKPKVTAASVSVDQVIEDVSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P677</accession>
    <name>A0A0B1P677_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 20s cyclosome subunit (Nuc2 cdc27) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002076">
        <property type="protein sequence ID" value="KHJ32446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P677"/>
    <dbReference type="STRING" id="52586.A0A0B1P677"/>
    <dbReference type="HOGENOM" id="CLU_008850_1_0_1"/>
    <dbReference type="OMA" id="WHSPQAW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="703"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="771"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="828" mass="93523" checksum="C84A49A95584C196" modified="2015-03-04" version="1">MAPSYSCISSQLRQLIYYHIDNNLLQNALFFAERYIAYDQRNLESAYLLSHCYLRLGDNASAYEYSKSAGLRGAHLGCAYVFAQACLALERYKEGINALEKSRNLWLGKNSFGRHSSSSRQPLADAAAVNCLLGKLYSGWDNKSKAISYFEDALKLNPFIWDAFTSLCDMGVNIRVSNIFKMNPEIEAILKINYHDHNEKLMHHKDTKNTSNPNLEQKRNLNRPNSVVIDNLDPFNNLSAKGTKPEPFGTLDSSRKLGESNSSSSTLPSSRSGSSNLETIETPNGPSVPNDKTTNSNRHEFSSVYSTEPPQAPIRKTRTTSALGMDLGMDIPKMSRSFNKRAQRFQEAIEEPSVIQALRPTSVVVTSIGDRKRTISGQVVPRHCPEDLNAPQRRSVRLFQKQPIISKSLSISLPNVAAPERELKKAKPPVSRIVKPCASFSSIGRQASGNNKISEDNIELDHREVLSRSQIGITSNTNQKIYEAEILKQEEAVKTLLELSKKIGNGYYALARYQCSEALQIFNSLPRTHRESPMIMTQIGRAYYEQAAYGEAEKVYKRLRQIAPTRFEDMEIFSTILWHLKRETDLAFLAHELINASWKSPQAWCVLGNSWSLARDHEQALKCFKRATQLNPKFAYAFTLQGHEHVANEEYDKALVSYRFGMAADKRHYNAWYGVGRVYEKLGKYDKAFVHFSAATAINPTNAVLICCIGTVLEKQKKPRQALQYFTRATELAPRSALTRFKKARTLMSIAEYEKAQAELMILKNIAPEEAMVHFLLGKLYKCLKEKGLAVRHFTIALNLDPKASQQIKEAIESLEYEDENDESLMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P693</accession>
    <name>A0A0B1P693_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002251">
        <property type="protein sequence ID" value="KHJ32194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P693"/>
    <dbReference type="STRING" id="52586.A0A0B1P693"/>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="OMA" id="NTKLMIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="27384" checksum="430075D088FAE185" modified="2015-03-04" version="1">MASSSNSTSLFYTCILYNSTILAEHSTSASFQSSSLLSVILPKISHNVPQKLTYTLNSKFIHYIADAPSEFPSNASAGRLTYLVVAEPSLGRRIPFGFLFDVKKKFLEDYPVLVTDFASLPHYGAGSFNSELKKMMIKHATIDEGKQDAIQNLQGEVDNVRGIMSQNIDSLLERGERIDLLIDKTDRLGGTAHDFRIRSRGLRRRMWWKNIKLILLLIFVVLTLAYLTTAFACGFPGWSKCISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H5</accession>
    <name>A0A0B1P6H5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000970">
        <property type="protein sequence ID" value="KHJ34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6H5"/>
    <dbReference type="HOGENOM" id="CLU_010668_4_0_1"/>
    <dbReference type="OMA" id="TETERCC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="302"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="818" mass="92322" checksum="D66FDECC7712ED58" modified="2015-03-04" version="1">MNYTACSVIYVNKTAKHDELVRQDMDISVLLESLTPLSLYTSPCRPSQNTELLRHNIKKLMRVFNEVYICASGKSCISKLFELSRGSVIDLVPIIVLIDVPNEDQPNDRFSNEIQSSEFISPGGFSNIKEDEFTQCYLNLEEKYGLELLQYIASEIGRQRLSSLIVPLAMVEAPNLDTYITRSNSLISLQPPHILSPRETFNHRDLSSSSNYQLHTVQSLDTGAVDVLISPIAEERLSSLLIHAYRAHYNALKEHRALIERRRNRKQSWVGLDVDDQKPFAYLREAMVSGLMDSICQIGVHTPPPNPLKISIELNRKEAITEAIASWNFSAHHFTDDELLHAALVMLEHTLKMPELEPWRISTESLTGFLLASRSAYNAFVPYHNFRHVVDVLQACFIFLIKLGRIPPFPDMKIELSSQSSTLAETIRPYDALTLLITAIGHDVGHPGVNNAFLTSLNAPLAQLYNDRSVLESFHCAAYSQILRCHWPSAFRSAEMRQLMISTILATDMGLHFEYMKKLARVKEDIISANTSAENSTQWSPGELRTLACALLIKCADISNVARNFEVASSWTLILTDEFSRQATMEKDMGIPSVLFAPPVREITTLGKSQIGFIETFAYPLFDGIAEVMPAMTFCVEELKRNKLIWNERISKKLNITKEDFIVEKETQLFTSKTKARRQSYIGSQCLTVPSQRKPKSRPYLKPLDVNLSTANFQNLSPFTNIFTSKSSEHSSSRESSRPNSPLSRPSSYKQGSISTQCDSPVSMNSMDFHIDSEHIERSESLLFNEEILTRKLSLQALQLDNGLCRNETESGVSICCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6J9</accession>
    <name>A0A0B1P6J9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative sec23 sec24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1813</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000964">
        <property type="protein sequence ID" value="KHJ34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6J9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6J9"/>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="360"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="615"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="711"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="838"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="996" mass="110922" checksum="9E6950B42AB322C7" modified="2015-03-04" version="1">MSGSANYQGEPHGDPSNKHQLQHQSGSVLTHQINSESSFSDQAFDNSQFYSSTSYGAPHASGYYSSQGAPNHDASLEVQMGGLNVTSSIPNRRKKAKDRHAYHQIGSAEAPVLTQDSSRVVPQYLDSSNSAQTNNLLDSQFPAQVNAPFIPKAPVSQAEFASRGGLSTDPVFAANVQTSSQGTVNPDEIPSIPKTREIVSQYYLSHVYPTFERHVPPPAFVSFVAIDQGNASPKFMRLTMNNIPSTADALSSTGLPLGLLLQPLAPLQPGELEIPVLDFGDTGPPRCHRCRAYINPFMVFRSGGNKFVCNLCNYANDVPPEYFSPLTPQGSRVDREQRPEIMLGTVEFLVPKEYWSKEPVELHWLFLIDVSQEAVNKGFLATFCEGIVAALYGYDNEEKTRNSRNQRYFPKNCKVGIVTFDKDIHFYNLNPALDEAQMMLTSDLNDPFVPLHEGLFVDPQDAKSNITSLLSKLPTLFTHIKNPEPALLPTLNAALVALEKTGGKILCSLATLPTWGPGRLFLRDNGKQQNEESEKKLYSTEHPGWRKIAEKLSQAGVGIDFFLASPNGGYLDIATIGHVSAVTGGEIFYYPNFTYPRDSEKLINEVIHSLTRKTGYQALMKVRCSNGLQVSSYTGNFRENKFGTEIELGTIDENKALSVMFKYDGKLDGTLDAHFQCALLYTTSTGQRRVRSSNIIASVTDNAKDCIKFVDQDAVYSLIAKDAVSKITTTSLKEIRGALSEKNIDIFAGYRKNFSGSHPPGQLVLPENLKELSMYILAIIKSRALKGGQEQSDRRVHDMRMLKSLGALELSLYLYPRMISLHNLELEDGFTDDQGHLKMPPSIRCSFSRIETGGVYLIDNGQNCYLWMHAQTSPNFIMDLFGENFNSLQALDPNLSSIPILETHLNAQVRNIIEYLKTRRGSKALTIQLARQGLDSAEYDFARLLVEDRNNEAQSYVDWLVHVHRYVQLEVTGQRRKEESDNSNPPYFPGLRPPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Y5</accession>
    <name>A0A0B1P6Y5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative an1-like zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001618">
        <property type="protein sequence ID" value="KHJ33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Y5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Y5"/>
    <dbReference type="HOGENOM" id="CLU_052358_2_0_1"/>
    <dbReference type="OMA" id="RQYCLKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="309" mass="34300" checksum="ADCAEEE15DE76BBE" modified="2015-03-04" version="1">MTSTLTSKLSADEKDPTLIGAHCQLKFCSRLDFLPFQCESCGYTFCLDHRSETAHQCTRAGEWAARRREENLKSQPLGIQKNMQEMERYCASSNCKTIIGTSLSISVHCTSCNQSYCLKHRLKDKHDCCNLTVASLSFTSNPSVLEQQLDQAKTALSKLKAWGSAQRANVSRSIPKIRPSPTTARIITANNLKKIAKGDDKLPPEKRVYVQVEAEATTTSSKLPSGAFFYSKDWAIGRVLDAAARALQVQNVNNESNDEMKKLRIFHIEKGRLLDFNEKVGSVLLNGETIVLLRGVGPSVPDLIDFTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z8</accession>
    <name>A0A0B1P6Z8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000856">
        <property type="protein sequence ID" value="KHJ34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Z8"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="MDSEMIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="59036" checksum="A17F5658DF1D4A49" modified="2015-03-04" version="1">MSHLIEQKGGLVIYPHACKSNQPHQQNTERNKIPEETSRKTPIAPSHLQAHDLRANITQRSENSPEKAPEAHDVPPELRKIIEAEKRRAAKITANLRTCTIAINGVQMALSTDRADGNKEFSQGLLIYLRAAIAQFMANGPGTTLPVLPSKPTQSLQVKQKEKSALPSNKALPQKLRNTEEKTWASIARKGNQVTPAMPTLSAIPSSTQKHLRADKEKGKHSKPSTCDDRLFLCLAKEYEWRPLAPSAIREIICKRLECSLTDILLIRRTATGFALTAKDKETRQLLLDKSSMISAQNATIEPASDLVTYYIPNVPVTIQFSNNKVFVTKDMIEAEIKRVTQASPTTVRPHGKTKAGAPYQAWLAHFPRPHAPRVGFRIFDESGLALVYKPRQNVLQYKRCLNFHPTRGCSHALACANCASTMHLTINCKAPTRCRNCGGPHKSESRNYLARPSRSGPATKEQLATIRQMSQREYHAVARAKAAVLRAEVTALPSATLDPSEQTREKNTVTAIELDMTEAPVDDENNTETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P709</accession>
    <name>A0A0B1P709_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4782</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="JNVN01001877">
        <property type="protein sequence ID" value="KHJ32701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P709"/>
    <dbReference type="STRING" id="52586.A0A0B1P709"/>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="744" mass="86674" checksum="8C5A2CF0D378A4F4" modified="2015-03-04" version="1">MSLNQAVHLTGYEKETQALRRRDVPKVPKYETVTDINHKDDKQRRITKSSRSIWKYLDEWEFLIAPVVLTFLAFFTRLYKIGLSPIVTWDEAHFGKFGSHYIKREFYFDVHPPLGKILVGFSGFLAGYNGTYEFKSGEKYPAELNYTFMRAFNAFFGAVCVPLAYFTARELRFKQPAVWFVALMVLCENSYTTISRFILLDSMLLCFTFTTVLCWAKFHRLRDQSFSIEWFSWLFLTGLSIGCVTSVKWVGLFCTALVGIYTAEDLWNKFGDTMMPKVEFIAHLIARVFGLIVLPIMIYMLFFVLHFAILTKTGPGDAQMSSLFQANLEGTSVGKDGPLYVAYGSRVTIKNMGYGGGLLHSHIQTYPSGSRQQQVTCYHHKDNNNEWWIYPNRSQPNFNSEAAIQFVSNGDVLRFIHSQTGRNLHSHEIQAPITKAHREVSCYGNTTIGDDKDHWKIEVLRDTVSSEHSKVRTLTTSFRIRHSVLGCYLRAGNINLPQWGFKQIEVTCDKKNNPRDKFTHWNIESHWNDKLPAADARAYKSFFFQDFIHLNVAMMSSNNALVPDPDKQDDLASKFWQWPILHVGLRMCSWDDSTIKYFLLGNPLVYWCSTISLIAVTLLIIWYLLRWQRGYSDLMPTDIDHLHYTAIYFLIGWILHYLPFVAMARVTYVHHYYPALYFSILNLGFLTDWILRDRQARIQYIIYGILYTTTIGLYIYFMPISWGMVGPNKKYRYLKWFETWRVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P727</accession>
    <name>A0A0B1P727_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched-chain-amino-acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001862">
        <property type="protein sequence ID" value="KHJ32716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P727"/>
    <dbReference type="STRING" id="52586.A0A0B1P727"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="OMA" id="EAIMFGM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="36414" checksum="52FCD01E9350C344" modified="2015-03-04" version="1">MSVPELNSPIIETASQCTDHMIIANWNITTGWADPELKPYSNFSIPPTASFLHYATQCFEGLKMYRGYDGALRLFRPDINCERLLISSRRISLPEFNPKEIVKLIIALAAFDGPKWLPRSRPGSCLYIRPCIMGSQAGLGVASPKEAILFIIATFMPPAVFPHGLRLLADDTVVRAWPGGFGYAKVGANYGPSLMATFEAKKKGFHQVLWLFDDIVTEAGASNFFVIWKHPTTSKLQLVTAPMNDQKLILDGVTRRSILQLTKERLWSPSLLLSNHRKYADAQKYFEQLEIVERNFSINELIQAIKEDRVLEAFSSGTAVSLIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7E0</accession>
    <name>A0A0B1P7E0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative helix-loop-helix dna-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001961">
        <property type="protein sequence ID" value="KHJ32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7E0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7E0"/>
    <dbReference type="HOGENOM" id="CLU_017389_0_0_1"/>
    <dbReference type="OMA" id="RKHINNN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="306"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="60491" checksum="15CA75F2F21FB4A9" modified="2015-03-04" version="1">MEFSNPYVKNDPDGCFSASNNSKPLSTFSPQMFGSSAIGSVDQNGLTNSFVSSFQNSYGPSSRGGGGFDDEELLDSLASRDMQLSNSLMNGLGRNSDTIDQFCYPSNIYDHNNASLSMNNNIYSSTPDADTSVASPYLQNFNQAQHRVSSHNFGTSLHSPSSFTGSPILVSDINGHTPRDQSSFLRQGIKIGMSDTKSNNLRSPLTPKTPALSSLHIGSAETGSGFVTQPIRTASAHGHQKSSSNQWDQTSSSFNSFGGDFSPIRSAHINAQISDILRGSSMPVKSNCALQTANNGLQSQEMKRRRRRESHNLVERRRRDNINERIQELSRLVPMHRLEDEKVRKALQNNSPLSPILAGTSAPPLGLSPPQATSGLAGPGARRAAAGNITTGIPIEEKDKGPNKGDILNGAVSWTHDLMWMLHLKLQQQEELANYIVELGGTFPFQPSEDEKRMQTELMDAIFKNNVDKFHYSRAPGSGLRVPKHTDLKGDSINSSNHNEKIESLSPENQNSNDSIQANLDNSNIYWNGQNSADSGNGSISFKEENEFCMDITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7P6</accession>
    <name>A0A0B1P7P6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nad-binding rossmann-fold containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000740">
        <property type="protein sequence ID" value="KHJ34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7P6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7P6"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="NSLACGP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="28436" checksum="BA0709616B66ABC1" modified="2015-03-04" version="1">MESETLFSVKDKIVLVTGGAKGIGRMISEGFVRNGAKVYISSRDVKAGEQACKELNELGRGSAHFIPADFYRLEDCNGMIEKLQKLESKLHILVNNSGSNWGAPYDKFPESAWTRVLTLNLTRVFTITQALTPLLERAATPNDPARVINIGSVDGIRIPALETFSYSASKAGLHHLSRVLANHLGKRYITCNTLACGPFESKMMAATLKSFGDQIKNEIPLKRIGKPEDVVGACIFLSSMAGAFVNGTTIALDGGSLVFAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7P7</accession>
    <name>A0A0B1P7P7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="7" type="ORF">EV44_g6091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01001489">
        <property type="protein sequence ID" value="KHJ33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7P7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7P7"/>
    <dbReference type="HOGENOM" id="CLU_050234_1_0_1"/>
    <dbReference type="OMA" id="FHVSIGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="318" mass="36281" checksum="E46956B937C076E5" modified="2015-03-04" version="1">MALVEYTSSDEDSNMNNRSSISSTSKSERAAPRITNSTDTPDALPPLPAKFHDLYASTKRLSTKDDPSLHGGRVRISPHVVGNWPTHIYLEWHPSTIERELLHQLIMTIQEKDCSFQVHSLLTSELKAPLPLHVSLSRPIQITTKQKDSISTSLRQAIECSSVQPFEISFTKLEWVSNFEKSRWFLILRTSSRHGNDELQSLLQICNNIVQRHGLLPLYEDPKYFRNVTSRLEKLSHIQSSNIATCSDENHKLKSTSNSTFNTFHVSIAWSLNPPSQNIVECMENTNEENFEIISKLKAKFEHIKLKIGNIDFENLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7S8</accession>
    <name>A0A0B1P7S8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001861">
        <property type="protein sequence ID" value="KHJ32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7S8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7S8"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="46124" checksum="594E697A3024F921" modified="2015-03-04" version="1">MRRVVITGIGAVTPLGIGIRQVWSKLIEGKCGIVSIANLQPVYKWKELPSTIAGLVPEGFQKDGKWNSSEWLSKEEERRMARFTQYAIAATQMALQDSGWWPEKQYDKERTGVCLGSGIGNLNEIYQTSIKYEQSGYKKVSPLFVPQLLINLGAGHISMKYGFEGPNHAVSTACTTGAHAIGDASRFIAFGDADVMVAGGSESCIHPLALAGFARSRSLTTEYNDQPMISSRPFDRDRSGFVIAEGAGIVILEELEHAKARRAEIYAEIKGYGCSGDAFHITAPRENGAGAFLAMRRALKNASLSPKEISYINAHATSTPLGDDAENSAIKQLMLGHDGVGKESDIAVSSTKGATGHLLGAAGAIEAIFSILAVKENVMPPTLNLHCIDNGFNCNYIPHFSQQKLVKNAISNSFGFGGTNASLVFSKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7U2</accession>
    <name>A0A0B1P7U2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001439">
        <property type="protein sequence ID" value="KHJ33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7U2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7U2"/>
    <dbReference type="HOGENOM" id="CLU_000288_77_1_1"/>
    <dbReference type="OMA" id="YGSSMVQ"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="647" mass="71419" checksum="B2F181286E402AEF" modified="2015-03-04" version="1">MVFEQREFSNNAVGVGRDAGLDGIYIRGRGKRPITDYTSTMVCWLRNRQPGYKGGYQGELERPSFSFIIDMLPPLSRVCSPADAVPSRHLHTSLNKNKHPVNVVAWTPEGRRLLTGSSSGEFTLWNGTGFNFETIMQAHDVAIRALSYSHSDDWLLSADHDGLIKYWQPNFNNVKVIQGHGDAIRDLAFSPNDAKFVTASDDSTLKIFDFAGGAEESVLNGHGWDAKSVDWHPTKGLLVSGSKDHLVKLWDPRTGRCLTTLHGHKNTITKTIFEPVKGLCLATSARDQTARIFDLRMMRDILLLKGHEKEITTLIWHPIVSSLLSTGGGDGTIFHYLLDECNNVPGTLPTLAPYDSPDPSTAPTQTIYPAHKINHAHEFPVWSLHWHPLGHILASGSNDRSTKFWTRARPGEMDIAKDRFHIGEAAAEAQGTYDRRGSRRQRQEEEEQEIEDEIDGLVDQQMPLKVPGFPGIPGLPLPQTGIPQIPGMQSSKNSNNRGILTPLSTITNKNTPIPNLSVVNPDNRPDFSRLADMMQKVGMPPTVNTNNPQFSSRMLASPGMIPPPLPGFGMNNYSSLPGIDSSNFIHHGVAVGASTNNPPDSQYLDNVGNNSITNSSSGGSIRRKGPLPSQEESLQMEQRKGKYTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X4</accession>
    <name>A0A0B1P7X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative saga complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000936">
        <property type="protein sequence ID" value="KHJ34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1P7X4"/>
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    <dbReference type="OMA" id="GNWMDGS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
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        <property type="entry name" value="SGF73"/>
    </dbReference>
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        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="374" mass="41429" checksum="3913AFECCDAFD5DD" modified="2015-03-04" version="1">MAPLASNESKSKVIAKKVVQGDRPYGSKIKLRISAPKHVKPGNWREGTIVDDTTNLESASTNNFQPPSGPVVNLLDNASRQTFPTGRPLEDPIDLIRCIICKKMILKSVSGPHVNACNAIKKQKAQRKKEQKEARDRERREAEVVADDDNDDEDGDYKTSNVIKKGKKRKADTDTDRVHKLKKKKDEPKPRVPKFRGPVDVERQCGVLKDGVPCARSLTCKSHSMGAKRAVAGRSLPYDFLLAAYQKKNQARQQKAAINANAPLEDEDPAQGPIDSDDELSTVMQGLSNWNPQPVVPPVVQIPIDRKYMRERLREQLAQATNGFTVNIFKIKVMTDVGADADADADWDENDVGISRKSSYTTGARRSVGHESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P810</accession>
    <name>A0A0B1P810_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000683">
        <property type="protein sequence ID" value="KHJ34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P810"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="324" mass="35713" checksum="D4D7277147B88718" modified="2015-03-04" version="1">MAPPLVSKRALPSEPPDTGNRVSKQKPTSGRIPQATAAKTHLLLATGDVFGKVVTNEKMLSEEYRSTDLNYDSDDSMESSTDQRASKTPENVPPEEHFPMLSEITQIRKDARTSRASHNSSDDSQNDAAKIQHPGIGADFLALLADGASRAMRGERVYCSVSKPVPTINQSSNDTWAEKAKFQSSGTKILNIKNQTIKASPPQGQSKEDRRVMIRLNPHHEARKSGSFELRQAIQKLVPDSPLVTDGWIVPSDIAALAPTPVEAAVILQAKKATEDRFGNAFVERQEVWTTFFISPINKRIKGLDDFCDPMDCLLQEELAHINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P811</accession>
    <name>A0A0B1P811_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001392">
        <property type="protein sequence ID" value="KHJ33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P811"/>
    <dbReference type="STRING" id="52586.A0A0B1P811"/>
    <dbReference type="HOGENOM" id="CLU_1416137_0_0_1"/>
    <dbReference type="OMA" id="CFLREWI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="22273" checksum="BB16F8F05BDC3CE5" modified="2015-03-04" version="1">MTNLYRSRAMQDAEMSNSSFLPSLPSELLFHILSYLDIPDLLSISRTMHYLRTISLDPLLHTYRLQRASVILSRAIPSRPPLTELMARRVYITRTTLTALNLGRSLTMIRLKRQLERRPTVERLIELGVLPPECYLNQSNGISTTLGLYRRRKVVQKEKVRNFLAEWIGELSKRITRRMIDSSRSTRDASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P862</accession>
    <name>A0A0B1P862_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001363">
        <property type="protein sequence ID" value="KHJ33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P862"/>
    <dbReference type="HOGENOM" id="CLU_1778839_0_0_1"/>
    <dbReference type="OMA" id="MKTGVRP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="15842" checksum="ACFD57A076F9F572" modified="2015-03-04" version="1">MSPHYVKLSLASKLKTANSAIEKVTVVNSGFAVTAASEAARNLLLQEARVLKDLDMKLEPASKWVSVLVANAPDRLNTLNGVVPVTAEMVSEETSMKTGVRPTSVRAFKSLLERPASDWILHFATGTSSLGGRIFEKSGRLVEFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P870</accession>
    <name>A0A0B1P870_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P870"/>
    <dbReference type="HOGENOM" id="CLU_1587723_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="19671" checksum="B6AB64F39F658D4C" modified="2015-03-04" version="1">MGLKLDQETHPLILDSSTESQENMEKFPTNRRPHVRQMEEVDAETVENWFLSTGATLGLGIPDITSRESVLKFLYIYRDLNATELKHIEPTDLYEHKVRLKEGVEPWKRSHQRRWPVGQEYWLQKTVREGLRCGMYERIVIANGELSSWNVQPVLVPKDKTDPDPWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E2</accession>
    <name>A0A0B1P8E2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytokinesis protein sepa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000603">
        <property type="protein sequence ID" value="KHJ34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P8E2"/>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="OMA" id="NHYWKAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="257"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1635"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1616"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="954"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1623"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1660"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1707"/>
            <end position="1716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1760" mass="197787" checksum="19D682A9659C1E76" modified="2015-03-04" version="1">MSGEFKLRNTPAGKSLFSLSRSRQKHKRSTSDEILGADLEKSRSDSSKSARSSRHTRNSSSTISADDGFNTLSIDQSGINMAPSAITSISYESVTADNKSPISVEFLPRGDQIPMARRDLQSHQINKSGVSVPYGIRSIATMSPNEGKTQQQQSGSSRTNGTNLSMGLNSKYDSFSTNSTVQSSTYGRNSSDHSSLDSTNERSSVFSASSSRAGHSIKQQGVTSSNLSPQVSMNRESNRLGRVTSVPQSLLEPPSPTKPNDDRFIEEEFLALMQKRGWHNLPEQAKRQMMAYPPEKKWTLVHQDRLTEYQGEQRRRATMRGNMQQGQYGRDMEVMANSDEEGTPEWFVKKVMQNNITAKQLQSLAVSLRTQPIGWVQTFIECQGQITLTNVLGKINRRQAQGPVPLDGSISEKDHDREYEILKCLKAVMNNRYGADDALAHQQVIVALASSLISPRLTSRKLVSEILTFLCHWGDGEGHLKVIQALDYIKTQTGENGRFDAWMRVVEVTIDGRGKMGSLVGASDELRNGGIGMENLLMEYAVATLFLINMIVDAPRKDLQLRVHIRAQFMACGIKRILTKMEAFQYEVIDKQVERFRTNEVIDYEDLLEHESSSNKDSTEVEVKDLNDPNQIVDAIMQKVRGSRTQDYFISSLQHLLLIRDTQEEEQLRMFQLVDSMLTYVAMDRRLPDMDLKQSLNFTVRSLLDKLHTDSEARQALDEAMQARQIASSAMAERDEMKAFIEMGADGLVVKLQKQINEQLDIIHILKRQTDSLKLELENMTNIRAKEAQQNELETRELYLMLRDAQDIAMSSAANMKRGSPEEIDVKKKNGIINREKLMDRLEMQIERQKTQYKLEGRLWADAIDPSDRLRALREEMQTTGAQDSVTRKAQSTTRDADSKLTRGQSQIQKTVDSESSQTIKLQENKDAPEYLREMKSTVKKYDASEDEDMDNDGATTGDSHTSLDSNLPKTPTDEISTSKKVIRQSERFSDSTNLMNNDEIAQDKSYFEEEADTQVTSKDLLPPTLPLPQVDSEIIDKIVETTSIPTSIPTSIPTSVPTSVPTSITTSVPTSIPTPIPKNVNIPVNTSSTSPPPPPPPPPPPPTSTPLKTQISQPPPPPPPPPPPPPPPPAPPIPGKAPILNSHPPPPPPPPPPPPPMSGAKGLGMKFGAAAPPPPPMPGMIPGNFPSTYSAYSNLPKIGLPIVRPKKKLKALHWERVDMPLKTHWAIHLVSAAEKEEKYAELSRKGVLEEVEKLFSAKEIKSLNKGGQKKSDKKQIISSDLMRSFQISLAKFSSYSVEKIVQMIIQCEKEVLDNPVVMEFLQKEDMCNMPENISKALAPYSREWTSNSSKEIRELDPSELTREDQIYLQTAFELNHYWKARMRALLLTRSFESEFEDISSKLKQIVAVSESLRNSISLINILGLILDIGNYMNDVNKQASGFKLSSLARLSMVKDAKNESTFADMLERIVRNQYSEWEGFVNDISGVVTAQKLSVDQVIQDARKYVINIKNVQMSLDSGNLSDPKKFHPQDRVFQVVMRVMKDARWKAEQIQLYLENMMLVYDEIMRFFGEDPADENARRDFFAKLATFVEEWKKSREKNIKLEAIQKRNELSMKRKNTAQKYDKSFDKENPTSPVSTGAMDSLLEKLRAAAPETRGQRERRRRARLQNKHQIRMASGQILDATDEVKEVEEDTTKSPISTTGSESHSDTISPRECDDDVAGRAALLLQGIRGGTESISDETDNSSRRESLRRSRRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E4</accession>
    <name>A0A0B1P8E4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000830">
        <property type="protein sequence ID" value="KHJ34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8E4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8E4"/>
    <dbReference type="HOGENOM" id="CLU_036650_0_0_1"/>
    <dbReference type="OMA" id="HLWGSHS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="188"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="32358" checksum="A893BD6B9EC74CF9" modified="2015-03-04" version="1">MNISEVDKKYLIRFAGKFQNDHPLLAQSLFQILGIFTMLSGYVLKARKLRRQEIRQDIRSEDLYLRIVWLAREGLKILEEYVLPMVANYGEPKTLSYKLRASFYYLFVLFHNHPTVNLKHTYNDLTLSSREVFDSELKGKNEKYSFTTQRPTRSSSIKLIHPFGAAYDAATAATNLNIRANLLIPAKDYRSTARHCFQEAIVLADQYLYGSHPIRLSIMVEYATFIFECLHDCEESRQLAKTTIAEVFNAQEGIDNETFTDSIQLVNILGKIMTTRDFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R4</accession>
    <name>A0A0B1P8R4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R4"/>
    <dbReference type="HOGENOM" id="CLU_617053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="444" mass="50915" checksum="304F9B2AF29B017D" modified="2015-03-04" version="1">MKSRNDQERSVSELIREIRLTNPYEFEPDSPTIPEKELYIIPDSYQSHQISKSETRSKSDLSPKSLSPVYPPPTLNSSSILTSEPSPRIVSQDSSGSSYDWRHLEGTSDYTTEKDNNYSTRRHSPSSIPIVEYYRYEQNKNSSISNNQHCLPYSIYHLESPSYIKKDINSKISRKPNSISTRSTMNYLNDIISCHESNYDNKSSKPTRTRSTTKNMFGEKGWLGISPDEILNPWNRDPEKSLRLKDKISIMEKLRIKLGEFAEKVDLNSSPNTGIRRESFHNQKVSIGPSEQAEIYMEVELMIVHTANSFLMNNFSRGRMSIDSIKKIVDVWKNKGHPGILEFMYDQATQRDLVALNQHNCCFHGKQAKNNLRITSMLDNWKQIASLMAIRTFCNADIIVFRILFDTELILESLGANSTILLRLQQIRNSALKKLKPNLAMGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U5</accession>
    <name>A0A0B1P8U5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001624">
        <property type="protein sequence ID" value="KHJ33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8U5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8U5"/>
    <dbReference type="HOGENOM" id="CLU_008392_3_0_1"/>
    <dbReference type="OMA" id="NVSHACL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="938" mass="103150" checksum="D5D182D161B165A1" modified="2015-03-04" version="1">MSEGSLELDPLWNDLDWAIGQLFFMGWEGTEVTHQIKTLIEDYHLGAILLTAKNLKNAQETTKLVQELQSIARNAGHPVPLLIALDQENGGVNSLFDENFVCQFPSAMGVAATNSLNLAYDVAKATAEEISAVGVNMIMGPVLDVLTNARHQPLGVRATGDDPQEVSRYGISTINGYKDAGVATCGKHFPSYGNLEFLGSSVEMPFITETIEQLTLSALVPFRNAIREGLDSIMVGGCAMVNDTMNVMHACLSDQVVEDLLRLDLGFNGVTISECLEMDSLSHDIGVRGGTVMAVEAGCDLVLFCRSFTSQKEAISGLKLGIENGMISRERIIISLRRILNLKSKCTNWHKALNPPGIRLLSAFRPSHLELSTRAYESSITVVRDRDHYLPLLDHLLPEDELLLLTPLVKPLPASAASKALVDTSNFQLLNYCRQVPRSSIMVGEEVFRELGRSLARQRHGKLLHTSYTANGLRPVHENLIHRASAIIILTADANRNLYQNGFTKHVAMMCSMYSKGGKKKPLIVVAVSSPYDFAFDSSIGTYVCTFDFTETALSALVRALLGAFKPLGTLPGTFRKSRKISKSKQNWLVEDWDMERDHNGLMVLINSIEKTLPMSHQSILSGTTASSFSIPSVPIISESIEEFHYVVRNSSTQALFGFCSTYYYPEAKLGSISTLLVDPAKRNLSVGYSLHQRALRGLLSKEGIKILQLGSLLPNIYLGVPMTDLTEGEKVKSWFLANGWDNSTAKLLYVLKLPKLCQWNPREDSTKNIQRISFAFDLIYGHENASGALEYIFKHAGPETLILYHLALQDGNGIVRAKSPVDGSIVGTVIMTRLKSKLSTFIPALNISQDELESPDEVDNCNGGILAPVIVNSPQATIILQGLVHLGIRQSKAQGHNSCIMSWVQDDQRDILIEMGFNVVNAFEQLNCEANKIEAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P951</accession>
    <name>A0A0B1P951_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytosolic j-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001401">
        <property type="protein sequence ID" value="KHJ33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P951"/>
    <dbReference type="STRING" id="52586.A0A0B1P951"/>
    <dbReference type="HOGENOM" id="CLU_015935_2_1_1"/>
    <dbReference type="OMA" id="KMCLGLD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000055">
        <property type="entry name" value="DnaJ subfamily C member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="427"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="61215" checksum="145B1580273337D2" modified="2015-03-04" version="1">MPDPEHMDEDTDTTNTTSNPSKINVNPLVREGSKKNGCSPSTNEEGPVPPPHRSNSNSPIVITSSPAEEAEIYKCAGNKHYKAKDYKKAIEEYTKAVQRQPSSATYLNNRAAAYISNGQYSLALDDSIKACLLEPQDPKILLRLARIYTSLGRPQDALDTYLRIDPPASAKDIAPAKAMLQHIQVAEDALKDGTTGSMALHALDQAEKLLGTGVQRPRKWQLMRGEVYLKMGNVNSLGDAQNIAMSLLRTNNADPEALVLRGRVLSAQGENDKAITHFRQALNCDPDYRDAVKYLRIVQKQEKMKGEGNVDYKAGRFSEAIEKYSEALEIDQSNKSTNSKLLLNRALCHLRLKNYKAAIADCERAIILDPSYTKARKTKATATGQSGDWAGAVREWKELQELDPSDSSIAKELRTAELEQKKSMRKDYYKLLGVEKDADASQIKKAYRKAAIVHHPDKNPDDETAEERFKDIGEAYETLSDPEKRRRYDNGDDLVDPMQGFGGGMHGGMSTVDPEIIMRMFSAQMGGGSGFQTFVGGMPGGAGRQRSSQTGFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P964</accession>
    <name>A0A0B1P964_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001388">
        <property type="protein sequence ID" value="KHJ33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P964"/>
    <dbReference type="STRING" id="52586.A0A0B1P964"/>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="681"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="822"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="958" mass="106639" checksum="A8E6D60FAA216EAC" modified="2015-03-04" version="1">MASLLDCTYSLVHQDNAADIPTLQELRTALEKGTDENKVETMRRILTIMLNGDSMPQLLMHIIRFVMPSKHKNLKKLLYFYYEICPKTDSNGKLKQEMILVCNGIRNDLQHPNEYIRGNTLRFLCKLREPELIEPLLSSARSCLEHRHVYVRKNAVFAIASIYQHSESLIPDAPELIYTFLETESDTTCKRNAFAALLSICHEKALEYLTTVLDGISNADELLQLVELEFIRKDAAQNSQNKTRYLRIIFDLLESNATTVVYEAASSLTAITSNPVAVKAAASKFIELCIKEADNNVKLIVLDRVDTLRRNNEGILDGLIMEILRVLSSPDLDVRKKALDITLEMVSSKNVEEVVLLLKKELSKTVDQDFEKNDEYRQLLIYAIHQCAIKFSEVAASVVGLLMEFIVDLNNSSAIDVISFIKEVVEKFPNLRPSIVERLVATLSEVRAGKVYRGALWIVGEYSLEASDIRDAWKKIRISLGEIPILASEQRLLDETSEDQETSKADQLSNGHSKPSNTGSSRVLADGTYATENALTSQSAITAKLEAVKAAQKPPLRQLILDGDYYLASVLSSTLTKFVLRHSQISPDHPRTNALRAEAMLIMISIIRVGQSQFVKAPIDEDSVDRIMSCVKILAELGQNQELEAAFLADTREAFRTIVQAEENKLAAKEASEKAKTAVQVDDVLQIRQLSKKNVDDGTNEIQLDLEKATGGDSTTEDLTSKLSRVVQLTGFSDPVYAEAYVKVHQFDIVLDVLLVNQTTETLQNLSVEFATLGDLKVVERPTTQNLGPHDFQNFQSTIKVSSTDTGVIFGNVVYDGASSTENNVVILNDVHVDIMDYIQPATCTETQFRSMWTEFEWENKVNINSKAISLKDFLEQLMASTNMSCLTPKASMKGDCQFLSANLYARSVFGEDALANLSIEQGEDGSVTGFVRIRSRSQGLALSLGSLKGLTKLGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P989</accession>
    <name>A0A0B1P989_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000455">
        <property type="protein sequence ID" value="KHJ35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P989"/>
    <dbReference type="HOGENOM" id="CLU_1256869_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="220" mass="24677" checksum="A205EAF067D02406" modified="2015-03-04" version="1">MQTDTCKGSARLSSAETPELRGILAEFQKYRILSDIADEVTLISLMRNGISKEMRTQVSLQQDVRRKYSYNDFVEVCKDRQLRLDLDRPSFQSIPFTMQCRNPQVDLSTRPPRRADFATIPSSKFTPIGPISSAQGPATGSNLVPPGEDPMILDKASLSYLGPDEKLTSAERKRRYELNLCMRCGKFGHKAIHCRPNNSRLLAITLGKDVDDNPNVTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D5</accession>
    <name>A0A0B1P9D5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative f-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001538">
        <property type="protein sequence ID" value="KHJ33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9D5"/>
    <dbReference type="HOGENOM" id="CLU_017706_0_0_1"/>
    <dbReference type="OMA" id="SWSQVFQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="191"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="57225" checksum="C9259F14026F5E3C" modified="2015-03-04" version="1">MELRSSELDEFRENWRQEVSAKLQLETNYRSSHSDSQACCQSLTLTTNPSYKISQDIGIREKNESLPYLGPDNDTVVEKSTREIQLCDVGTLATALDHYELAVKREDDGNLGESLDLYRKAFHMDHRVDRKYKNKYFPTEKSIQVVDLKSTQDLKSDFPNEAIFDKKDLVESLSSLSIQASASDNEDIVLSCPLASLPDEILVHILMSLAILDVASFVRIAQVCKKLAYLVATEQQIWRRICIGSEFGFGGMHYEWQPNSLYGIFGKGIINTDIQDQDQNQEMNILSRYDITKILLHNCYSSSWYQMFRLRPRIRFNGCYISTINYLRPGESSSSQASWNNPIHIVTYYRFLRFFRDGTVISLLTTNDPVDVVPYITKEYLDARQVRGSAPKFMRQALRGRWHMAKFSGSHDVKIDNSMNNENDIFLETEGVNEKYLYQMKLSLRSSNKACKNNKLIWRDFRSINRITNEIDQFRIKEEKAFFWSRVKRYANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J9</accession>
    <name>A0A0B1P9J9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative meiotic recombination protein ski8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001518">
        <property type="protein sequence ID" value="KHJ33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J9"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_11_1"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="7">
        <location>
            <begin position="266"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="468" mass="51598" checksum="AEECDB29A2013303" modified="2015-03-04" version="1">MATSNVLLTSALSNILPRICTKYTINATYRFNKTLVSASPVGRIFDHSVDKTIINFTTQHLRKFQNLRLLSLNISVSVNKWFCDLWESILRAVPKKKTSHSKKRSRQRAGKALKDVTALNKCSGCGHVKRSHVLCPYCVKVLELTDPYLKSKQYLSYHTIDDAHISDIFSLAVTPKYILSASGASAIKIYSTESADIPLFQTLSGAHKIGCHHIATSRDGRHAVSAGFGGEVKVWRLSKIENKGENGGEEWVEEGSILGENKAGEIWAIAISDDGQYMASTSYDGRINVWDLVAGRKKIREFETNGSFGMCLDLSRDGRLTASGHENGTVYVFNNETGRMIYSLPGLVRPVRTVAFSPHGTRLAAAGDAGIIALYDVKHGEQVANFTGHSAWIFSLDWSYTGEYLLSGSSDGKVKVWSIDQRSCVTTHGETGKTLWSVKWLPKTGRNERFVTAGASRSISLYREATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9M3</accession>
    <name>A0A0B1P9M3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative proteasome component c5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001496">
        <property type="protein sequence ID" value="KHJ33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9M3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9M3"/>
    <dbReference type="HOGENOM" id="CLU_035750_1_0_1"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="29283" checksum="E16D7DA134B8B4AC" modified="2015-03-04" version="1">MATIFSHHCPIESPQYSFHNTASKKEAGEQQHARFNPYTDNGGSTLAISGSDFAIIAGDTRSTSGYNINSRYTPKVFKIGGTTSSQDDATLVLSVVGFAADGQALKEEIDRVIKMYRYQHGKSMSVKACAQRLSIILYQKRFFPYYVTAILGGLDEDGRGAVYSYDPVGSYEREQCRAAGAAASLIMPFLDNQVNFKNQYIPGSGVGHELKEREKIPLPRSEVEALVKDAFDSAVERHIEVGDGLQMMIITKDGIQEVYKELKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9S0</accession>
    <name>A0A0B1P9S0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative extracellular chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000401">
        <property type="protein sequence ID" value="KHJ35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9S0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9S0"/>
    <dbReference type="HOGENOM" id="CLU_114655_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="59"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="22963" checksum="B986EEC9F6C558DB" modified="2015-03-04" version="1">MVRVVRARSINALMASVALPLGFGRISFPFPFPFPISILVLHLVLNFANRTCSGSTPDYCNNCQGSAFGSGCQTPSISSLFQTAIANGITDEDAGGQYYFDRANNLFWTWDTATLIARKFNDIVAARGLGGVMAWSLAQDSYDFGHILALQKGAREMHLNATKSETKNYVSSRIMISSSFGNQIQNTPTPPASNPWWKPNWLKKLWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA27</accession>
    <name>A0A0B1PA27_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000526">
        <property type="protein sequence ID" value="KHJ35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA27"/>
    <dbReference type="HOGENOM" id="CLU_1273091_0_0_1"/>
    <dbReference type="OMA" id="WWYDAND"/>
    <dbReference type="OrthoDB" id="3588018at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="25765" checksum="4166A6F05DAB32BE" modified="2015-03-04" version="1">MFDSLKRTLRGHNGRRRCISSFLPQDRAKEDAANIEAKMALLNLGQRRRSLHELQLPTIPHLKPLTMSVLTAALEDRTWAEKSPPYDSQKPIQRKPVPPQEIWPHNLRLNEAAEFDPKTPLTNKSIHSRARKTLKKRYQSKFTLDFNPPRGLTPRAYDFLWVDEEELDRKVLDDIVWVRQRYAQARKLEPTDQDIIWWYDANDFDDEFTHQTFYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA61</accession>
    <name>A0A0B1PA61_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative csep0407 effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000504">
        <property type="protein sequence ID" value="KHJ35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA61"/>
    <dbReference type="HOGENOM" id="CLU_1272083_0_0_1"/>
    <dbReference type="OMA" id="EARCGSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080568" evidence="3">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="187" mass="20121" checksum="774F1D552E31E389" modified="2015-03-04" version="1">MYIATFKTLLLISSIIGFQKVTLAAAIPEFRTKLSGKVFYGPVSENAVTVDFRRNVHATAQDGADSPAAAPATIPEARCGSHVYNSDYIQNTLATVTELKSRAATAGTSDFPKPFGTDGKVMIYPLLRSAQVFDGTTNSQPGPDRLAVGTEGMRYSVFTAEGQPDPENSVNFQTCEYLMPENAQIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA69</accession>
    <name>A0A0B1PA69_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative miz zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000984">
        <property type="protein sequence ID" value="KHJ34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA69"/>
    <dbReference type="STRING" id="52586.A0A0B1PA69"/>
    <dbReference type="HOGENOM" id="CLU_555732_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="491" mass="54128" checksum="98AF964754FBA961" modified="2015-03-04" version="1">MNGGRSHPDNIREREVERSNVTLNTFFGASRQKSWMFRGGTPVRPTPRSSQAITALSQASLAPSVPSPVFNHKIRSASLGKKTTSPTAITESERSLDNLEKSRKDISIVTEKLIHLPTSRDLNLSQSVPDLNSVSSQPHSPQILDPNILGSVSKSSTDLTIDLQKELPTFSETELSATVRKESVTTLPKPSNIEISTESDAEIAPVLQEEPILEASEKPKAVISTGTLTQLRVDPVTDVYVQPIQQLSIDICETPIELDPESEGAAHNLSLVPSASPESTGRFQSEAHADSRKSQDPSDRSNIVQTEIVNAVRQTENSMLTQSVNNDCHNGSESVPPKTLSPNLSLKPNSPAQKSHNIGCVHDIALTEESSMSSPPQSNKFTLKSKLTMIEAQLKSVGGLESLNTGLERPRFQLLIEACRVEDFFYVIFHQIYILWDFRREEVLTIQEIIDINSLQTGFRIVAKIIHDNNQLAPNHKRWPQITIGKPASMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAJ2</accession>
    <name>A0A0B1PAJ2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000937">
        <property type="protein sequence ID" value="KHJ34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAJ2"/>
    <dbReference type="HOGENOM" id="CLU_055871_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34872" checksum="444F4ECAFB3EC717" modified="2015-03-04" version="1">MVQLKLEDNDNIPETSQYMTAYGEIDGFDAISQLHDQSIHHALAAAAPIKDKTNRYNSLTFQGIMIDIGAAQWSTAGEAQVRALQKLRNITIDSLTAGKVKIIFGIGATTSLGTVSLETNIGIINFNVVPSNTPFLLSLKDMDTLKVKLDNLRNVLLQGNQEFPFVRKFGHPFLLLTDITTTIIYSCDTECHLSEPELRQLHRRFGHPSSRRLLQILKRSGHNVNSSIVKYLGKYCHLCQLHGKSLGRFKFILRDDIEFNHSIIVDVMYIEGNPVLHVIDEATRFGAAGWLKNISTQHTLDMLRNCWIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAL8</accession>
    <name>A0A0B1PAL8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fungal zn binuclear cluster domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001098">
        <property type="protein sequence ID" value="KHJ34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAL8"/>
    <dbReference type="STRING" id="52586.A0A0B1PAL8"/>
    <dbReference type="HOGENOM" id="CLU_744324_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="41316" checksum="714811707CFE0EAB" modified="2015-03-04" version="1">MKSTIVSKPVSSLRGITSTDTNSLAQSTEKKRNKLGYHRTSVACGHCRRRKIRCIASPGDRRCSNCIRLKKECNFYPVDQQSSNPGRRDQKGHCSSERKSEDSLTSKKNNQISEISSALPYPGNHGLPIIQTLGCSQTKQSHLINSSPSSNKVFRSEHDFSNSNGSVTTSNWMGSNTLHIRDTSQDISPYWASSSPKSQLQSNYSPFVPNIQVSPLHNWNTSHTDLSSTEELQWPATSRTMLFSNIQGSNRHHLFTSSDSTSLQSSDNQTNKGVSNLSLCSSVNPIPSIGPTLTSMNDNSSHRNLGSILPVSMSTWQQPYSLQKTANRSLEHFENWDENQTDSILMKVESSDEALSPYIYDGFGTGIFYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAQ5</accession>
    <name>A0A0B1PAQ5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g0397</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAQ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PAQ5"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="61"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="43238" checksum="37CF5C7F52120B2F" modified="2015-03-04" version="1">MTTLSNLSTFIHIMLRLVVRKFSTSIRKSNAVTSIASYKAEDTNLRGISISKAQGIAHDLTHAIGNTPLIRLKRISDTTGCEVLGKAEFMNPGGSVKDRAALYLVRDGEERGLLKAGGTVVEGTAGNTGIGLAHVCRAMGYQLVIYVPDTQSEGKINLLRLLGAQVFPVPAVAYNHPRNYNHLAKLHAQRLHENGKSGFWTDQFDNVANRRAHLETTGPEIWHQTSGKIDAFTCATGTGGTLAGTTRYLKTVSKGRVRCYLADPPGSILDSYLRSGGKLSERTGSSITEGIGQGRITCNLSKDIDLLDGSLYISDEKSVEMIYRCLDEEGLYLGASSTLNVVAAKEVAERLGPGHTVVTILCDGAYRYADRIFSKTWLEKKKLLGAIPTHLLKYITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAQ8</accession>
    <name>A0A0B1PAQ8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative zinc finger protein 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000267">
        <property type="protein sequence ID" value="KHJ35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAQ8"/>
    <dbReference type="STRING" id="52586.A0A0B1PAQ8"/>
    <dbReference type="HOGENOM" id="CLU_038712_1_0_1"/>
    <dbReference type="OMA" id="SHQRGIH"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000394">
        <property type="entry name" value="Zinc finger protein 836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="395" mass="45091" checksum="C7305E9C5F66EFD9" modified="2015-03-04" version="1">MDVMELVENEPNARPFQCDWQTCHKSFNRKSDLQRHYRIHTNERPYSCMQPGCGKSFIQRSALTVHIRTHTGEKPHQCQHLGCGKRFSDSSSLARHRRIHTGKRPYKCAHEGCLKSFCRKTTMVKHQRRSHQHGIHSSETDDGDSSESENGDSPSTPQHSGHLQWSHGIPLTHTLIPHTLSHQPPQIHRSQSYNDFTLDNYGVGNGYRNAFSPNQFTPSLSEADQSILNRPNQIPTTNAYYVADHHNPAVSTMNTNHSIQTFVPRQQVDTKEGILHSSPTSSSPISRASPDSYYSHQAHQPNYTLHNTNQLEQSSLLQYQPLTSTLVSHSQLSNPMTHHSHINQYHSPPTQGAWFEASQYQQPELINVYSPEEFTKPIDTNSFKNFIHQLELKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAV3</accession>
    <name>A0A0B1PAV3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ankyrin repeat containing protein yar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAV3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAV3"/>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="OMA" id="EAENVGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="23645" checksum="CD73EDC8841EF515" modified="2015-03-04" version="1">MSLTEEEIDDLLYFARIGDYDEFKSLEIELCLREKIKVYELLQVAKDENSGNGILHMAAANGHCDFIQKICKSLSQPSPQNTIMLSLMNAQNLAGNTPLHWAALNGNLNTVQVLMEQGAEPTISNKMGHDAIYEAELNDKKQVVEWVLKEGGKSLDQVISKEETDHNFTHGNSKALESEDKYSEDVHLSLEQISLETDETPHRTLDRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB17</accession>
    <name>A0A0B1PB17_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000822">
        <property type="protein sequence ID" value="KHJ34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB17"/>
    <dbReference type="HOGENOM" id="CLU_1300500_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24639" checksum="C8ED8263450AA4E5" modified="2015-03-04" version="1">MDISLGLNARDVLINHIELSLPQTYVLLSRGILKMSSDQIANQVVHFTRQASRAELQNTIFQPYVEPKSSLSLQDHNNQGSSLLVVPPGSQNDNIFLSNQKETLDDSAYAALQNNECRICRRKGHWAKDCSFRNYNRLPHQQYEKDIYPKIKKSSKFFQKSSQLKENFHKSRPQFRKNKLKNNVYLISDNNNDDSDYDNENCLNMYMLVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE1</accession>
    <name>A0A0B1PBE1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nonsense-mediated mrna decay protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBE1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBE1"/>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119224" checksum="D3367CF3EAAF8A7C" modified="2015-03-04" version="1">MNAAGLRSRIVATLDADADVRRRAELELKAAEEHPGFTDALVDILQTEQEPSIRMSTAVYLKNRVNRAWSIDSNSSHQSKPIPDDEKQRFRERLLPLLASSPSQIRKQLIPVLQKSLHFDFPEKWPSFVTITAQLLNTNEVPSIIAGLQCLLALCRVFRFKTGESRSDFDKIVTATFPRLLEIGQGMMNETSEEVGEMLHTVLKTYKHATFFDLASILREQSVTIGWCSLFLQTVSKEFPMAALPEDLAEREASHWFKAKKWAYFNLNRLFVRYGNPAALHKGNGENYTEFANNFIISIAPEILKGYLQQIEKWVERTIWLSRPCLSYTLAFLDECVKSKEMWNHLKPHLDSLITHVIFPIMCLSSDDIEKFDTDPEEYLHHKLNYFEEASSPDVAATSFLVTLTKMRRKHTFTILTFVNKIVSEYETADDEKKNHVAKEGALRMIGTLSGVILGKKSPIAEQVEYFLVRFVFPDFQSHHGYLRARACNTVEKFEQLEFKDSNNLLTIYRKILDCMADPDLPVRVEAALALQPLIRHDVIRTSMQQNIPQIMQQLLKLANEVDVDALSNVMEDFVEVFATELTPFALALSEQLRDTYLRIIRELLEKNEKHDDDDEIYGEYLDDKSITALGVLQTIGTLILTLESTPDVLLHMESILMPVIKVTLENKLYDLYNEVFEIIDSCTFAAKSISPTMWQAFELIHTTFKAGAELYLEDMLPALDNFVQYGAPHLIENPQYLEAIFSMVSDMFSDTKVGGVDRICACRLAEGIMLNLRGHIDQYVLAFIEIGMRMLTNNEAKSKAYKLHLMEMIINAIYYNPALALHALETKGVASKFLGLWFSSIDSFPRVHDKKLSIAAIVSLLMLSPDHVPISVQQGWPRLLQGIIRLFQTLPAATKNREEALREDYSLDNQYGNDEDDEWKADDTAWNDDGEGDDDKDDKDEKNAYINYLNEEAQNFKNLESHESDDELGEESLLETSLDRIEPYVLFRDALLKLQQEQPQLYESLIKILTAEEKIILQGVIHQADINASQAAAALQGNMPPTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBH9</accession>
    <name>A0A0B1PBH9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001098">
        <property type="protein sequence ID" value="KHJ34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBH9"/>
    <dbReference type="HOGENOM" id="CLU_1972101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="127" mass="14912" checksum="BB748390343B14EC" modified="2015-03-04" version="1">MKLLINQIPSRHQNETHASQITKFSGKTNVVQYIEDLEARFFLQPYSHDTDRKKVIVAIENLCGAEDDLTSNAPKEWARLEVRLNPHLKDNWTAFPDRLRLRYQNTALRQKKVEERQNLIQKGNTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC44</accession>
    <name>A0A0B1PC44_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative rna-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000621">
        <property type="protein sequence ID" value="KHJ34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC44"/>
    <dbReference type="STRING" id="52586.A0A0B1PC44"/>
    <dbReference type="HOGENOM" id="CLU_012131_1_1_1"/>
    <dbReference type="OMA" id="MYDDRSP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="100"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="707" mass="79555" checksum="7248A228FBF8141E" modified="2015-03-04" version="1">MPDHRVDEYQFSSSQGYRHNRKDFQRSSRGPSGESRFQQDSYDRERWESRDMDNHVYERSRSPRRESRGRYTDRDREGYVSPRRERSRSRSPYYGAPPNRNVILEGLPFDFTQEDIFNELQNDKKVEGLEEVRVIKDKRTGQPRGFAFAQFVGISEARRFLQDFHPSIFLHGPPDKKHAISARPAKVRIAYSRERDDREKAGKGEDDWKCDVCCLPNFSHRTLCFRCNAPRTRSTAQGIVMAQSNQAGSSGFVTTGDSDASPDGTASQFLLFRGLEPGVTEELLAKGVRKLMKIKPEISSNNTFTVKKNKISSTTDDASLGAREGSMRRVLLVRDRKTNDSWRYGFAEFSSVEDAQAAMIKYKSLDKFTISSKPVLAAYIHAGVFVPIIQSIKDEDFNFTFTPLSNPSIKLMYWDEAAYVNELITSIDEDRSTSIVKEIENVGNAAIVSNGGLAPGGKIGEPRPKKRKVEKETKVVAPHLQFWTNRHAELHGLPIKETVESLSTKISESPKPKPVELPKTQSFADLEAKCCLLCRRQFKSEAEVHKHERLSKLHNENLKDEVLVAKALLKLGKSTGSPSDNVSYRDRAMERRRAFNQPKKPVLQNNRQVAPLKKEAEEPLPTPVPSKGAALLGKMGWTAGEGLGVRGTGRTEVINTDLYAQGVGLGAAGGKIGDAAEEAQRQTKSTYADFLNKTKDKAKERFENLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC61</accession>
    <name>A0A0B1PC61_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000607">
        <property type="protein sequence ID" value="KHJ34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC61"/>
    <dbReference type="SMR" id="A0A0B1PC61"/>
    <dbReference type="STRING" id="52586.A0A0B1PC61"/>
    <dbReference type="HOGENOM" id="CLU_060354_0_2_1"/>
    <dbReference type="OMA" id="CSYDERE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="30700" checksum="7AEB578B0FFC36CA" modified="2015-03-04" version="1">MSVVSLLGVNVLKNPARFGDPYEFEITFECLEALQKDLEWKLIYVGSATSNDHDQELDSLLVGPIPVGVNKFIFEADPPDTSKIPDAEILGVTVILLTCAYDGREFVRVGYYVNNEYESDELNTDPPAKPILEKVRRNILAEKPRVTRFAIKWDSDESAPPLYPPEQPEADLVADGEEYGAEEAEEELEEEVVEGTDGVADADAMIDEGETTGAQNKSSKAVDEESDVGSEDLEAESSGSDEDEVEEEDHDDEPMELDTPEKSDGPENNTHSTDAVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM0</accession>
    <name>A0A0B1PCM0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000896">
        <property type="protein sequence ID" value="KHJ34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCM0"/>
    <dbReference type="HOGENOM" id="CLU_041940_0_1_1"/>
    <dbReference type="OMA" id="YQRQSMQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="414" mass="45922" checksum="DCDC0C44469263CC" modified="2015-03-04" version="1">MSLPPPQPTYILRGHGSQIHKVTFIRSNARLVTGDVEGWVVIWDLAIKRPTAVWRAHQAPILGLNDWNFDKIITQGKDNKLLVWKLDEKDEALMSKVLPVDVPDESRMKPWLLYSLDINTVNFCSFAQTEAPFNEPPNSLLIAVPDALSSEKVEIYHLPSSAKLQTIPASSLFKGGMVMSLAVLFHPITSLLTVFAGFESGHTTINHLVDSSWSMIYIAQPHTQPILSLAVAPDKTYYLTSGADAIIAQHVIPRLTPRSIDIKDVELAKIETSTKTLNTKHAGQQDITIRNDGKIFATAGWDGRARVYSCQALRELAILKWHKEGCYAVAFAKTNLFSTEKNGSFNSPSEHIPNFCLSIDKDPAGQAQSEIGAIKSSQISSTTVVSETRLWRAHNTHWIAVGCKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCR4</accession>
    <name>A0A0B1PCR4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCR4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCR4"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="VRWSKDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="17967" checksum="67161B81CDB18D29" modified="2015-03-04" version="1">MGGWYSKLSSLVWSKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESITFKNLNFNVWDLGGQTSIRPYWRCYYSNTAAVIFVIDSTDIDRLALLVFANKQDQPGAKGAGEISEALKLGELRDRNWSIVACSAVDGSGVDEGMDWLVETVKQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD45</accession>
    <name>A0A0B1PD45_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000663">
        <property type="protein sequence ID" value="KHJ34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD45"/>
    <dbReference type="STRING" id="52586.A0A0B1PD45"/>
    <dbReference type="HOGENOM" id="CLU_051551_0_0_1"/>
    <dbReference type="OMA" id="QGQCKVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="27493" checksum="0FF6BBEB5A942379" modified="2015-03-04" version="1">MNIKIPPNKALPQILEVPPPPLNVNLSAQKGGGESLTEILMSTTSAAEKRTQEAKLIFQKIATILDEARDKIELPEQLQKPYRDFIANLNIVARRHFERHVKDTPRPPPPYATSSIKQTSSIPAIPLNKTVLVAPPKKSTYAAVTKAPAPRIQQDNRLFVRVPPGHTALKMSPYAVMLDLNSFLKETLIREIQVIKTGFAICPTSITARDILYSRTEEIEAYLSTQGQCKVEKPTKPKAYLLSGIPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ8</accession>
    <name>A0A0B1PDJ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="5">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="5">EF-G2mt</shortName>
            <shortName evidence="5">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MEF2</name>
        <name evidence="7" type="ORF">EV44_g1442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000738">
        <property type="protein sequence ID" value="KHJ34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ8"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ8"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="OMA" id="GPQFTFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="792" mass="87360" checksum="4239C839F44EED3E" modified="2015-03-04" version="1">MLYYSGLTRCIGDVDDGSTVTDFLPAERARGITIQSAAVTFHWPPINNANNIRSNQQRSLCPHTINLIDTPGHADFTFEVLRSLRILDGAICILDGVAGVEAQTEIVWTQAQKFNIPRIIFVNKMDRDGATFEKTVKDIATHLRSFPIVCQIPWWEGGKGNFVGVGDAINLCALKWRPNTDGMNVKRLEIQDLSQEDPKFCAELIRARKCLVENLCEFDEPILDLWLQVNDDTMAIKGQDIQESLRRCIMDGSGKLAPVFLGASFRNIGVQPLLDAINNILPNPSERPDPEIRLGSQKGCLQEFLHGKLCLTSNSKKNKPNTSKSLIANLEACALAFKVVNDVHLGILVYVRVYSGSIKRNSSLWNSNLQISEKSPRILQMLASKAIEINQINTGQIGVVVGLKHTRTGDTLISYTSFNPKCGPPAPINNLQLRTIEIPPPVFFAAIEPHNIGEEKNVANLLAILLREDPSLQVNIDNDSGQMLLSGMGELHLEIARDRLINDLKAKASMGSVEISYRECVTSISPETQANFDREVAGKKGRASCRASIGPSNDIASITENSNTIVSGENSVTIEILSSATKTDPNNLLHLDLPINIIQTALSNGAMAALARGPRRSFSLYNTHVVIRYDLDTDFYGKETFPAALSSAAKLAVQAALKESFINNQIAIMEPVMNVLISCDEASLGAVIHDLSAARDGQIISLSNHEDHDNTNSFLPKIDLQKVYIPKDPFTIAESEYDATTPSHRRQVRANVPLREMVGYLKHLRSLTAGRGTFIMNFDKYEKLKESKEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDK0</accession>
    <name>A0A0B1PDK0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000083">
        <property type="protein sequence ID" value="KHJ36288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDK0"/>
    <dbReference type="STRING" id="52586.A0A0B1PDK0"/>
    <dbReference type="HOGENOM" id="CLU_027018_2_0_1"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="44381" checksum="4E3CE5AABAD2BFAE" modified="2015-03-04" version="1">MNMKSTNPLISTQEFSESNFEVALHPLVLLSISDYITRHTLRHQTGPVVGALLGQQNGRQVSIEHAFDCLTLEVDGKIELNQTWFNERMQQMRDVHKSPSLDIVGWYTTLPPTGPQPIHLPIHIQILQNYNESALLLGFYPSLVANGSNSGKLPLAIFESNFETDDKSKDVGDDTMIVGIDPNPSIRFKEISYNIETGDVEMISIDTIARGGGKATAGVKETGLTIHPKDYRSDIAMEGKAEKSLMEDRTLAREEEELIAFLTAKMNAIKMLQARINLITIFLKELFHASDDIQLNEQVNRSANHIVLRSIQALLNRLTLLAPANSTEYKQELISEQNDINLISLLSSITETIKDLRGVGIKHGIIESSRNVKNRSNSQWGNSSQKAPQKGVSGVGDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDZ4</accession>
    <name>A0A0B1PDZ4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000347">
        <property type="protein sequence ID" value="KHJ35575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDZ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDZ4"/>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="OMA" id="AYRNNEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="144"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="59371" checksum="9F2C338C5C1F3E7E" modified="2015-03-04" version="1">MFPRTPQVVKTLHRKHQCLTEISKKLLSTSPKPKDKTPYSRKEARNQNFKKESEYQYQKNLEASTKKDLLRNQDRKSSGTFESSQMPLRSKFMDPSFQSKKSRVLAGNYSKHEELNSSSKPEIIKELPDDDKEDVLFNTLFGARFIELNRPSKFNALNSSMIRKIIPRLQEWAKSDMVNVIIIKGCGPKAFCAGGDVVELVKLNRTGKEGQKESADYFALEYKLDHLIATYSKPYVAFMDGYTMGGGVGLSMHAPIRIATERTVFAMPETKIGLFPDIGASFFLPRLTGSIGTYLGLTGSKIEGANVFYSGIATHYLHSSSLHSLEMRLAELRFKDYDSLEERLGLLNSTIKEFDTGLPHDQEILFTDKRLESINRCFDKGSITSILAALEAEKEVDKPWAEEALKTLQAHSPTSLCVTLRLMQLGKKWSIAESFRREYMLAARFMEKSDFNEGVDALLIRKDLSPKWDPPVIADYETENEIVEPYFKTEGIKPIKLLNEIDFQEYPHNNYGFRSRVDVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEY8</accession>
    <name>A0A0B1PEY8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">EV44_g4385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000488">
        <property type="protein sequence ID" value="KHJ35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEY8"/>
    <dbReference type="STRING" id="52586.A0A0B1PEY8"/>
    <dbReference type="HOGENOM" id="CLU_090154_1_0_1"/>
    <dbReference type="OMA" id="WYMDESQ"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="20745" checksum="C9AD25F771BFFB2B" modified="2015-03-04" version="1">MRAYWYQDDGSDQRLPHDSGRDVSPEYLAQIGVLYYRVSSEDEVDKLAEQRHYRNRDVITVSPQKMGDIYEEKVRSFFTEHLHEDEEIRYILDGAGYFDVRSKTDEWLRIRLVKDDLIILPAGIYHRFTTDENNFITAMRLFKEDPKWTPLDRAPSVDINPYRKMYLQSITAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF40</accession>
    <name>A0A0B1PF40_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aminotransferase class i and ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000201">
        <property type="protein sequence ID" value="KHJ35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF40"/>
    <dbReference type="STRING" id="52586.A0A0B1PF40"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="OMA" id="PRDFKLC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034276">
        <property type="term" value="P:kynurenic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="36"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="424" mass="47838" checksum="D949BB40FDA8FFD9" modified="2015-03-04" version="1">MAMLNKILPASRVACLKQDVWSIVNEAAATSPKQPILNMGQGFFGYNPPDYVLQAAKSAIERVDCNQYAPTKGRPRLKKAIADSYSPLWGRKLNPETEITITTGANEGMLCAFMAFIEPGDEVILLEPYFDQYISNIEMSGGIMVYVPLNPPKDGGIKNTSSSEWTIDFAKLESVITPRTKMIVLNTPHNPVGKVFSKEELMKIGKICVQNNILILSDEVYDRLYYVPFTRIATLSPEIENITLTVGSAGKNFYATGWRVGWLIGPSHLIKHIATAHTRICYSTVSPLQEAAAVGFEDADKYNFWDSAKQQMKHKMDLFNQIWIDLELPFTDPEGGYFVLVNMKKVVLPDNYVFPDHVKNRGRDFRLSWFLIQELGVAAIPPSEFYTPENAHIGEDWLRFAVCKEDKVLIEAKERLRGLKKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFU2</accession>
    <name>A0A0B1PFU2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative heat repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000123">
        <property type="protein sequence ID" value="KHJ36165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFU2"/>
    <dbReference type="STRING" id="52586.A0A0B1PFU2"/>
    <dbReference type="HOGENOM" id="CLU_004060_0_0_1"/>
    <dbReference type="OMA" id="GNAPHDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118516" checksum="6D0648AC69DAC81E" modified="2015-03-04" version="1">MSSERIDDVQVSNLLEVLRTDATIDAKVNLINQIKSAIKQNNVPETCIVPLFEATRTAMTSQQAAIVSAGFTTLGHLLSRISRQEPKYLLKESSRTLPLVIEKMGDSKEKYRQLAAQCLTTFWNKAPSDVEKTVKSIGLTSKNPKMKDACMSWIVQTHQESAMPFKNYVSALVTLLEDADGMVRDTARNSVIALFQNASNVAKSDLKKQLKICNVRPTIVSAIVAHLGPSNYPETGESEIPTRSVFANSVPSVSSTRPLSQAQEIKIEQIEPAYVNTQRELESTFQEMHPCFEGRESEQNWLKREQSCTTLRKLNAGNAPNDFHEAYLVGVKGLLDGILKAVNSLRTSLSKEGCCLIQEITNTVESGLDPMVEILLQNLIKLCGGTKKISSQQGNKTVDIIISKVTYNSRILQHIWAACQDKNVQPRTYASGWLKTLLKKEAHHKSHIEHAGGLDLVEKCIRKGLADPNPAVREAMRSTYWVFASLWPPRAEGIISSLDTTQQKLLENAPDNPNSYKNTNLMNSRPGLGFSKSTSIPQKPSLKDTMLAQKKAALANRNLFNRPGSAMSSFSPVRNTQNSSTSSDISAARLRIDSTSISHGGLSLAPMRPSKLRATVRTDLATRPATAGPYSIRRPAHAPSYSESSTSPSLISKGLKNRINSTGTPKRISPRPSTSHSTHITPPNHTIPKSTGLNKSISPFTTSRKPKSSEVDRSPSYRLSNRNEELTMVIPSKLNEINNEKTRKNISIVDSSDEEILVTPLIRSRKSKDPLLSIDDKLMNIRASVVVPTQEDSQSTQDVSKPEQEVPLAFQPHSESNLTDNLEQCPPLLVSGIKKILSQNLDVHGFRKLQGIIREIKSEWSENKFGILLSGLFDYLEAPLTSLTPEKRQDVKVQVLATIKLMFKKDPEAFKPYLTKGLGSLLKIRSIHDSRAYIVSGLELLSSELIMICEPSSTIDNILSQLEMKEATETENRCLSMGLLMLKEVLNIKKSFIPSDTQLENLSNLAIKCLNSDDSGVRMDAVQLCVAIHERVGGETFWKVLDGMRDDPKSLITYYIVKQQKELATTAAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFX0</accession>
    <name>A0A0B1PFX0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFX0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFX0"/>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="OMA" id="FYSKAFF"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="42865" checksum="B11F84E1184BAB18" modified="2015-03-04" version="1">MPDKRHFAPNAIPPRSSSTGAPTGLNSFQYAFYKSFNKSPGGESVNCSKRNRSDKIPSNLHITNLSGSSKTSKINRYNMSFHGKSSWSAEKDKILLGPYEYLDAQPGKDVRSQLIAAFNQWLEVPSESLEIITKVIGMLHTSSLLVDDVQDSSLLRRGLPVAHNIFGTAQTINSANYVYFLALQELQKLRSPKTITIYTEELLNLHRGQGMDLFWRDTLTCPSEDDYLEMVGNKTGGLFRLAVKLMQAESKNLKDCIPLVNLIGVIFQIRDDYQNLSSQDYSDNKGLCEDLTEGKFSFPIIHSIRARPDNMQLLNILKQKTNNEQVKRYAVSYMEETKSFEYCRKVLMTLIEKAKKMIAELDDGSNQGQGILKILEKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG51</accession>
    <name>A0A0B1PG51_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG51"/>
    <dbReference type="STRING" id="52586.A0A0B1PG51"/>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OMA" id="QGMLKVH"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="41895" checksum="10212F4852FDDD03" modified="2015-03-04" version="1">MSFKARRQPLSQRIIEPNATNKLNLPSGVRPSPLDGRLTTSTGTKSLDSLLAGHVGLALGNVLLVEETGTTDFSGCLLKYYAAEGVVQGHQVHVLGLNESWGTELPGIAIEKHNSTKSSESAPVDKMKIAWRYERLGEFGAEAKERTIGPRNNSLESIFCHDFDLNRRLPISSYSNIKFVSASNIKKSEALTSPFTSYLSHLISQINNSPPNTIHRVVIPSLLSPLFYPAKFCNPSNILQFFHALRSLLRKYRSQLTAIVTLPLTLYPRDTGLTRWMEILSDGVFELAPLTSTVSTTLSSSVQLAQDETPQGIFRIHRVPIFHEKGGGNYWGGAGDNLAFTLSRRKGLVIKPFSLPPVDGDPEAARGAPKKVKSNDIDIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGJ7</accession>
    <name>A0A0B1PGJ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin carboxyl-terminal hydrolase 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000302">
        <property type="protein sequence ID" value="KHJ35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGJ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGJ7"/>
    <dbReference type="HOGENOM" id="CLU_019318_0_0_1"/>
    <dbReference type="OMA" id="VIDFDIV"/>
    <dbReference type="OrthoDB" id="5369841at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="672" mass="73582" checksum="349A15BEB059EBF4" modified="2015-03-04" version="1">MDSQCTLSWEDVKSIQTNLKNIQTTQLNHSERLLKLEKRQADDAAIKSVWGSNTVFPNVLGGASQPDPLPILHDDLFDKFDGEQGQNILKSLRLEDDEEPVRRGTSRANSVRFDITALQSSSWSVPGRNSADFVSIRPNSSFGNHSMMERSLSHKSDGRQSSAGHSLSDFFSVASGRTSSLGLDVNYDVCEANQKETVHDPPPGMFILGPVPSIIRCWLAGDFSHDSLLYAAVCSGSQRSVIHYSLIKELGLQELIEKEESSQNIIKLTIYLPEATIIHPLSRLNSQNLQLPIISTRFEVIGINQKTDLKKNICVFLGNDTLRSHNADILFSRNLMTIYGDDKCKLSIPFVRPEDDELFKNLCTTNLSQEKVGLKATAAPFTPIDAKSRSDSKYTPIKKADKSDQNSKLDLVKDGQQPISSETILTSPNLSDGLDSLRFNSENSALVGSVDILAEHVKEHNLVSKQETEVAVSDVSSRKSTNAILDPWRQEKNRNWSQSGYQPARYGGNRSMKILKPSSKLNSMTLKSASPSNPENSSSSSSSSSSSSHFKTASSYDSSPLDVALTPSLSSNEQPGKKNYFMNGSGVGGHENGLLRRWESARKVNLDDSGKIKNFSVSSSNANIGLENSSNPIGGASAFVWMNSGKGQGNIIKHARNHITPTTAICKNADQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIT5</accession>
    <name>A0A0B1PIT5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000035">
        <property type="protein sequence ID" value="KHJ36399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIT5"/>
    <dbReference type="HOGENOM" id="CLU_2098642_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="116" mass="13191" checksum="7193F48EB11E7283" modified="2015-03-04" version="1">MQDSDNEYNQNLIEYDVQETAMQSTATTNYDDEFPCLEGIENQSENQNVSENVKSTPYEGSKFQLMDKVKGHFDITNPYLQEIEKDSPRVGADFMALLVEGASRVILGQRILFQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PJ19</accession>
    <name>A0A0B1PJ19_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rna exonuclease 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000001">
        <property type="protein sequence ID" value="KHJ36474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PJ19"/>
    <dbReference type="STRING" id="52586.A0A0B1PJ19"/>
    <dbReference type="HOGENOM" id="CLU_022453_4_0_1"/>
    <dbReference type="OMA" id="GQCTYHP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="455"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="72041" checksum="5574D26610825D54" modified="2015-03-04" version="1">MFSTKNLFSNITCPYEEFCLLPRCIFKHSNIPSKTSLKTSTAPIEEEKKPETTESCLPAIPQVLPPNSSLISDLDSLSPKKKIVTPDNSNSTNTKSLSKVNDQVKKRKVEASSIVDDISLPALKRKTVDGNSVSVNMRLSPVSKSLTSSQLSGLKNTLSEQTANVVSREGLNPRALKVPAPASHNMRYQLLKALYSQFKRLNTELAIDKKSVQAKLVLSDQSLITRALDFEEETAVISPLIYANLIKNKILIYKRMNVKQWAEERENEIIQAQKALEARSSLSKSGTAPGKTSEVIKLIETGLSPEEELKFLPELKIDFTKTSEHGFVTSIPTDQEIELAQKGIEAANGWEICDRCKSRFQVFPGRREEDGALTSGGQCTYHHGRTYLTEISTGSSKRIKKYRCCGESLSDSHGCTTAPCHVFKISEVKRLASILNFQNTPTPDSNEAITKQKRQPICLDGEMGYTVNGLELIRLTAISWPSGQDLFDVLVRPMGPILDLNSRFSGVYPEHMANALPWTPNQSLPKNSKSPHALPILSSVVEARSLLFSYLSSSTPLIGHGLENDLNAMRIIHPTIIDTAFLFPHKLGLPYRNSLKLLARKYLNRNIQDAGNNNSGEESSNSLAGHDSKEDAFAAGELVKYVLKTRKEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV41</accession>
    <name>A0A0B1NV41_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ash2-trithorax family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004737">
        <property type="protein sequence ID" value="KHJ30222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV41"/>
    <dbReference type="STRING" id="52586.A0A0B1NV41"/>
    <dbReference type="HOGENOM" id="CLU_014420_3_0_1"/>
    <dbReference type="OMA" id="GFRYTYA"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="166"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="569" mass="64612" checksum="53227C365D4088A0" modified="2015-03-04" version="1">MEIDGTPSLPKREKTPLVLISNSSIPQKRTQEDDHITFISSPLNPDFKETKPLEELPYVQRAARVKKESLKKRESKGNTNGETNIRDTNLERSSVKNKKKKKPVVEIGPLRYKLATVPGYNDFKPPQNPGFNPVERKSYSNGIEIVFNETIDHVFNKKSFNYTSAVPDPIFRHSLLFRQSEVPPYTARFSFEDRASNILIDQEAKHITTDKGWRSAKANVCMREGRWYWECRVNCGTPRLESTSTTGISGPHVRMGIGRREATLDGPVGFDCYSYGLRDLGGQKIHMSRPKAFFPNGENICEGDVIGFEVNLPSASLHHKIVNGTYKPKIDFKDLGNTGIEKADIIRDRAPIKIKDYWVFEQAAYAPGKELQDWCSPAPTAFKHEVKPCFTHPSVPLRTLPHSYIKVYKNGILMGTAFENLFAFLPPASKPATVKDMFFREGLDDGTLGYYPIVSVFQGGCAEVNFGPKYWFPPPEIKQFDNGDIISNNQPLDDFNEQRIRPLNERYDEQIIEDILADLVDEVYFWVLDEAPTDTDDMNHILYNGIHLSENSSNDRTGPTTNEETKYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVT2</accession>
    <name>A0A0B1NVT2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cyclin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005231">
        <property type="protein sequence ID" value="KHJ30083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVT2"/>
    <dbReference type="STRING" id="52586.A0A0B1NVT2"/>
    <dbReference type="HOGENOM" id="CLU_018149_3_0_1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="50582" checksum="A6D59208F33CE5BE" modified="2015-03-04" version="1">MSSTKRGGRKLVPLHKRAMSEFLHQNVHFGMIRFLADKTRRVIQCDPSPIKERGTTMYSASSSQITSPGHQRRQILNADEVNVVGDDDETEGEKIKRKNVPPLEDFISHLVKKSNVQVPTLMSTLVYLERLRLRLPPVAKGNNCTLHRIFLATLILSAKYLNDSSPKNKHWANYSNLRQNSGFELMEVNLMEMQLLELLDWDLRVSNKDLFRNLDPFLSPICDVIFRREHQAPSYYTHEYPDPIKNPLPLPPPFHPTVSHHARRGPKYIGAQSKAGHVPRKSVPTSIVSPTRSHRVLLRTSPPPAAAVPDLLRSGQSSVDSSMNSSLSSSPLTRSTLSTPTLTDFPDNSLSSSKRNSSNNHTTGQKLATKLDRIFNLHLDHGQKDKLICNPSLDHIADQYLGTETQSSPQEGKNLSPSVCLAHKHAEPAKSSRRSRGPVHFLNRLIGKGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW49</accession>
    <name>A0A0B1NW49_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4955</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01003884">
        <property type="protein sequence ID" value="KHJ30612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW49"/>
    <dbReference type="SMR" id="A0A0B1NW49"/>
    <dbReference type="STRING" id="52586.A0A0B1NW49"/>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="OMA" id="WKRPTLD"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="460"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ30612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="793" mass="90085" checksum="9763BC8B3BC505A0" modified="2015-03-04" version="1">MYGQRLTSILEFPDPFAVITLSGEQTKTTSVIRKTLSPYWNESFDMRANEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVLDLSSKQDEMLTRDLKRSTDNLVIHGQLIINLSTNLSEPLPSNSSSSNNNTSLRPPKTLGISHASNMSSSGLPSPSHASNSGTVANSGGTMSTAQAPAAGINGSSNESNFLNNNSGRQTSVFSFFEDAQGRLPDGWERREDNLGRTYYVDHNTRTTSWNRPSAGGTTETQRTERDATTQVERQRHQNRTLPEDRTGAHSPSNASTVVSGRGSPSNVATMLATGATTAGTGELPPRWEQRVTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGGPNTNRGSIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPALRILSGQCHVKIRRSHIFEDSYAEIMRQSASDMKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGLAIFHRRFLDAFFIGALYKMMLNKAVSLSDMEGVDADFHRSLQWMLDNSIEGVLEQTFSTEDERFGQTTIEDLKPGGRDIEVTDSNKKEYVELMVKWRIQKRVDEQFQAFITGFHELIPSELVNVFDERELELLIGGIAEIDVEDWKKHTDYRGYTESDEVINFFWQTIRSWDAEQKSRLLQFATGTSRIPVNGFKDLQGSDGPRRFTIERAGEINNLPKSHTCFNRLDLPPYKTLEMLQAKLTIAVEETMGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWH4</accession>
    <name>A0A0B1NWH4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003705">
        <property type="protein sequence ID" value="KHJ30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWH4"/>
    <dbReference type="HOGENOM" id="CLU_1099181_0_0_1"/>
    <dbReference type="OrthoDB" id="3595120at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="253" mass="28414" checksum="9865391F08AF70EF" modified="2015-03-04" version="1">MTPQIEDLGFEDFGRTQLNRKSCVIGLDDEKLGSKDVKIDRVPTEDSHHQDEPTPKSAKKAHKRGQKALQHLCEIMGRSGKGPINYTKIAEEIRVSVVVDKEKRDNASNSLDNIISYVNMEERAFCVPVVIRTSKDGRFVDVRLPSSVAQADTGSNMVVISYGLIKYINLPMKLLSEDGFSGLTMNVENETSLPLKYFTSFQINFLGISRHIEAFLRTRNSSFCLVYPGSMMRTQKFTFGTQLLKSAIQIGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWV3</accession>
    <name>A0A0B1NWV3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mfs monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003579">
        <property type="protein sequence ID" value="KHJ30812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWV3"/>
    <dbReference type="STRING" id="52586.A0A0B1NWV3"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="GLYAWTV"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="435" mass="47437" checksum="FB589B4B9BA07A6C" modified="2015-03-04" version="1">MSIREVKTHVYDVEDLSSLESTSSKRPINSDAIYDQPPDGGWFAWLQAGLCALIMLNTWGLINSFGVFQTYYHQTLLPNNDHSSISWIGSLQVFLLFFIGAFSGNLLDMGFSRSLFLNGSLLIVIGLLMTSFATTYWQLFFSQGICIGLGNGLLFCPSLSVLTTYFTSKRSIAMGICASGSAIGGIIFPALFSNLLPVIGFSWTIRAAALIEFVCLAICNIGLRSRVPPKKSGGFIDIDSLKDKSYILFTLGMFFNLWGVYFAAHYISLYASTILKLSSKDSSNLLMVLNGIGLIGRIAPNFLADFYAGSLNVLIIVCILSGIMNFCWVAVSDRTGLYSWAVFYGIVSAAVQSLYPAALSNLTKDMSKSGTRTGMVLTFISLTALTGAPIAGELIERQNGKYMYAQVFSGLSLMIGSGFLIASRMMESRKLAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWX5</accession>
    <name>A0A0B1NWX5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003538">
        <property type="protein sequence ID" value="KHJ30847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWX5"/>
    <dbReference type="STRING" id="52586.A0A0B1NWX5"/>
    <dbReference type="HOGENOM" id="CLU_042344_1_0_1"/>
    <dbReference type="OMA" id="IPNMGAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF65">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="3">
        <location>
            <begin position="224"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="36619" checksum="571D97F2CA8A8129" modified="2015-03-04" version="1">MSSPSYRATNGKGGSDELPKNLALTVIGCGTIGTALLGRIMEACERAKDKGDDVIFNRFFATVNGEESRYNLLNRFSTYQSHFRVYCGENDLWMDTADVVILAFKPSMVEHILSQRGVRDALAGKLVISVIGGTPQKRLCDAISKSIPSEVVEKRSSLYSDISYAPTDKPPYLKRVMMNIAAEYGQSITVIETSPPSDINSGYEKITQWIFEQCGKISFVSPETFDIGGILSAASGALLSVALDGILDGAVSQGLARSQAKEIVSQSLISLATLLENGAHPAILREDFSIPQGTTIAGLMSLEEDRARWAFSKATIVSSERSKNIASTVWEDKNSTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXD6</accession>
    <name>A0A0B1NXD6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative triose-phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003302">
        <property type="protein sequence ID" value="KHJ31057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXD6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXD6"/>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="OMA" id="IWFRSPT"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089721">
        <property type="term" value="F:phosphoenolpyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990536">
        <property type="term" value="P:phosphoenolpyruvate transmembrane import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="83"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="515" mass="56733" checksum="D277406F9D48F627" modified="2015-03-04" version="1">MEKFPDLQESSEGSYKSLPSSTKQQNFHANGTRNVRIGSTWIGKHSRQKSLSDAFSTIRARSGSVASNVHDVADALKAPVSAKLVILCIIWYMSSALTNTSSKAILNAFPKPATLTILQFAFVACFCIFFSWLSSLSSIFRESIPALRNGLRYPSQDVLVTTMPLAAFQIGGHLLSASATAKIPVSLVHTIKGLSPLFTVLAYRFIFDIRYPMATYLSLIPLTVGVMLACSASFAGNLFGITNALLAALIFVTQNIFSKRLFNEAAVAEYSGIRSRKLDKLNLLFYSSGLAFLLTSPIWFWSEGLDLLRDFFHDGSLDLTAGTLSKPAFDHGRLALEFLFNGTFHFAQNIIAFVLLSLVSPVTYSVASLIKRVFIIVIAIIWFRSPTTNVQALGIALTFFGLYLYDKTKSDKVDRKAKMLNMRERSLLPQSSLLRKNLTGRHGQPRSNSYSLGPLGIEKKDEILGNIRGSRQRGSSNAVWPPTKTFQDNEWPLHELGSSPASGGILLGQKECIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYB5</accession>
    <name>A0A0B1NYB5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative zinc finger protein pac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002970">
        <property type="protein sequence ID" value="KHJ31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYB5"/>
    <dbReference type="STRING" id="52586.A0A0B1NYB5"/>
    <dbReference type="HOGENOM" id="CLU_012842_1_0_1"/>
    <dbReference type="OMA" id="QWGNCRT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000458">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001875">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="584" mass="64422" checksum="A24A0CBA09816B62" modified="2015-03-04" version="1">MSAPGPKDLQDSSATTSSPTTRPPAVAIAAATDKSLVCQWDKCSERCVSAEALFNHICEKHVGRKSTNNLNLTCGWASCRTTTVKRDHITSHIRVHVPLKPHGCDFCGKAFKRPQDLKKHVKTHTDDSVVLRSSEVNQNGINKAIDVLHYRGSQSAYYKQSLAMPGNHGQYANAHNSVHNSYFTQQPNPYGSVYYPSTNGTDSGHNSSYDNRKRSFDTLNDFFGDAKRRQIDPNSYSQVGQRLLALHGLPIHHTGLSDYMSTGSSLVSVENQNGGNQLSVSTHQYALPLPNLRTKTDLMNVDQFLEQMQSTVYESSNAAAAAGVHQPGAHYTHAGINFRQSHSPPQTNTHNLNHLKSNIPSHSANLIPEHQQTIRSNAPNNTPTLTPSSSTMSYTSSHSPVSPNGLSPTVRNSNITSVAYPSLPAMSMGYQSHSSNTAPTSSLGPIFDNEVRRRYSGGMLQRSSNPLRRNGELISMDESPIESQNGKVNLNHSVNQNIDPALSEVNSHAEPLDNSESARDKAEEAWIKNIRVIEALRNLVNERLRRKEYESDDDDVSMTGICSKQLKEENFSRISYPTLRTDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYE3</accession>
    <name>A0A0B1NYE3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative peroxisomal-enoyl-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002944">
        <property type="protein sequence ID" value="KHJ31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYE3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYE3"/>
    <dbReference type="HOGENOM" id="CLU_009834_6_0_1"/>
    <dbReference type="OMA" id="WFPGVAD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF3">
        <property type="entry name" value="PEROXISOMAL D3,D2-ENOYL-COA ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="306" mass="34003" checksum="3935F587B9784493" modified="2015-03-04" version="1">MASIYTISTSKLYLTLFPTFFFKKKKRKLTVYWLNRPQTLNAFGGDLMIETISALDWLDKNSDTVITVLTGAGRFFSAGADVRSVNETLTDSNLGVDKTRDQVDADGQQVQKTKEKITYLSHFAPHVELMRSIINHRKVFVVALNGPAIGGGAAWFPGIADIVLASSNCYLQVPFSSLGLVPELGSAPIFSQIMGVHRANEFLMFGRRFDAPELEACGLFNRVFPELNFQDHVSQYLSEIIATSDGQSLMEAKRLMNEPLRIGRLAAVMESVDALANRFVAGAPKDRFQMIKRKLEAKSKGRLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYI8</accession>
    <name>A0A0B1NYI8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative vhs domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003312">
        <property type="protein sequence ID" value="KHJ31043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYI8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYI8"/>
    <dbReference type="HOGENOM" id="CLU_883382_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="36765" checksum="FA0527C2B0A9B2B3" modified="2015-03-04" version="1">MISYEDLRAIPRNYQIPDEVDRKYCTVICVRKKSDEQEEQESRLFNLEEQKETISSRISEAVIYSVNLINVLKQFNSEEYPKTETESKKKLTKDEALEKFKKDEAQKRINEGEGLKNFERAQAIARTNRDEALKRFKKEQVRRDLTDSITLRAKNCKMVRAVILGYTEKITSEEWLGPLIFVNEMLVTALRMYKKIIQPEGAEFYLGDKQEDVTSSKDKQKEDPVACTQKRGDVKPSNLSKTEGQDVFQECAMTKLFQGDENNPFFNISDAPIIDTNYSVANSAFLNNNPFSEYNYPSYNNPFSRDYIRQRNREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYL0</accession>
    <name>A0A0B1NYL0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005070">
        <property type="protein sequence ID" value="KHJ30120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYL0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYL0"/>
    <dbReference type="HOGENOM" id="CLU_113002_0_0_1"/>
    <dbReference type="OMA" id="DFAAMIW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14387" checksum="7CC7D06368306132" modified="2015-03-04" version="1">MATTTNIPTIVTETMQRLSSKTSVIATLAIDRKTSTILASSGQTGVFQFSKASSITSSLNSNNEDHPPPSSINDFALKIWDYVVNTSKMILEIDQEDDLKLLRVRTKKYELVIVPDNNYIFVVAHEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ14</accession>
    <name>A0A0B1NZ14_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Putative blue-light photoreceptor pcmada1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g4933</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002700">
        <property type="protein sequence ID" value="KHJ31647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ14"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ14"/>
    <dbReference type="HOGENOM" id="CLU_007918_2_0_1"/>
    <dbReference type="OMA" id="DSEMWTK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="543"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="874"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ31647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="964" mass="109004" checksum="BC59B8B1709022B2" modified="2015-03-04" version="1">MNDLNHSQYSTEQLPQFYPARRPSAMLQSNGLPMTYASHDLSYPTDHISLLDSTTQESRRNSFDEIFRENDKEILRRHSSTGRTFDIGVEYGSAMKDESIESGGLDGFQYISANEQTGLDSRRGSSAAFESTGYDEMECSTNLCVPQFDMHQNMPANNILMNSNKLYQNRPGNIYDNMMSSLMGPEILMEEENSRINFFNSQYSMCPENTGLDQNKGEFMITSPQQEGLSSRCESISNSDTVKTTPTEATQNIQSDKAAFRSPINPAVLHSMRNLSPGENTDPQNNFSHQDGPKSMFTVPQTAVTNQLVVNQSKSPYQNLYCRSGFDLLGALTKVVSRKDPEIKIGKVDFSCAFTICDALQYDNPIIYVSEVFEQMTGYNQYEIKGQNCRFLQSPEGRVVAGTKREFVDNDSVRYLKERILEKKEAQRSVINYRKGGQPFMNILTVIPITGEDDKTIRYFVGFQIDLVEMPASVQGRTASGNFNINYCQSRIPRYLWQSSTANLGQALDFDRSISREDVSTVLASIYAGTESELMRRMWDKILIENTDDVVHVISLKGLFLYLSPSSRRVLEYDASELVGTALSSVCHPSDIVSVTRELKDTSTGAPVNVVFRIRRKKSGYTWFESHGSLYIEQGKGRKCIILIGRERPVYALDRFDIEMAGGIGDCEMWNKISISGMFLFVSSNVRNLLDRSPSDLIGTSIQALMRTESGLEFRKTLAKARTGIIISHKHEILGKRGLMMQAQTTLFPGDSLKGQKPTFLVAQTKLIKSAIKSTAGTISQTSTASEFEIPQYHDFLGTESQCGGSGSVIGSQHVALASKSNIFDELKTTRCTSWQYELRQIEKTNRLLAEELAILISNKKKRKRRRVAGYMQRDCANCHTRVTPEWRRGPSGHRDLCNSCGLRYAKQVSCSNFSMQLKLEQFIYHYEYFESKSHYKKITFFYLYHLSSFFLHTLLILLTINYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ52</accession>
    <name>A0A0B1NZ52_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002671">
        <property type="protein sequence ID" value="KHJ31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ52"/>
    <dbReference type="SMR" id="A0A0B1NZ52"/>
    <dbReference type="HOGENOM" id="CLU_797389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080383" evidence="1">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="348" mass="40221" checksum="A30D1A4ED2E62581" modified="2015-03-04" version="1">MQLQLVLIVITIVFVSITSSTDFWNEQTVFTEPAYYDCGSWIFYEENILEMLSSLGENIDQLGHPFIEPLYNLRPDYRKISIPQELCKGNHLPGLRQECHFSVIIDQMAQIVDIVSQMNNGFFIKCKRVDQLVPQPQPYNLNECNFECGHKIISHRVVHLSLTRAISDDAPIDLRGTQYHGNLYAPEIDYWIYPIPEKNQKKTAAIVPEYTYYTVLSPYGEIKDVIAKLMHKGFMKCDCKTKAPLVVSLDKKKGNYMCGTKLLTLKFMKRTALHAKRYKQRSKRWNDFPKPYNGPGSRPGQSYFPILAKGNFYIGSVGRKFKYFIVINSNFEIEFAVMKTPEGYKLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZB4</accession>
    <name>A0A0B1NZB4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin carboxyl-terminal hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004390">
        <property type="protein sequence ID" value="KHJ30365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZB4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZB4"/>
    <dbReference type="HOGENOM" id="CLU_045150_0_0_1"/>
    <dbReference type="OMA" id="HAWNCTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="209"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="35460" checksum="65407B67C8A4C88F" modified="2015-03-04" version="1">MLVKSKFSPSSDAGVNTQYALHVWDSHIFCLVISVADHLHTIIKLFLVFFFNHEIMALPAPLELLNSIFITLTTAPVFARPSSGKPPSNPFQTLPNSHRALLTTLHVLLPSTLLQAFDLLDRGLITRISLLNENECIEKHRSEFVPTSTTQIDAETVIKKHNNVNTEKSDFNIKSPTHTLYQVRSSHYRAKLSGRQNHSNIASHSPLSYTVYLDAWNCSCAAFTFSAFPVSESTSSPWSNIKNISDRDKLNNRRQKGEWVFGALHLEHDEMEFPPICKHLLACLFAEKWEDVLGSFVKEIQLGREEFAALACQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZB7</accession>
    <name>A0A0B1NZB7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative autophagy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004381">
        <property type="protein sequence ID" value="KHJ30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZB7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZB7"/>
    <dbReference type="HOGENOM" id="CLU_059602_0_0_1"/>
    <dbReference type="OMA" id="GTFSRCF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="40569" checksum="0DAC71735D626E00" modified="2015-03-04" version="1">MGWFWSQQDCDSGSDKDPLRNLDPSLREFLKKESPVKYYNKENSFSKESPSLSLASKSTTSTSKSSEVPLNLASEGASSNQHNASEDNESRTFSNSSPSTSSLPLVYKDGRYNHLWKSYQSPEEVDRHMKSDQEKIDEILEGFKYRRAEIGKAALENCALEQAALSDCWTHGSAKARLMLCREENKAFNRCHTMQSKFLKALGYLSTFDRPAVVDEEIQMYADTLYHRMLEEEKLIEAANAKGEPKPKFPPLLSHTPSFSLDSGDQKALQDVEKETCLPSDLKSSVRKQLKTRLEELTDIEREVEEQAIKAEIRAGESLGRNLADIYEKQKEERKARKEKGKETIGDKVISIFGFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZD4</accession>
    <name>A0A0B1NZD4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative double-strand-break repair protein rad21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004333">
        <property type="protein sequence ID" value="KHJ30390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZD4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZD4"/>
    <dbReference type="HOGENOM" id="CLU_015775_0_1_1"/>
    <dbReference type="OMA" id="WAKEGLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="628" mass="70259" checksum="4D897663FCBA7367" modified="2015-03-04" version="1">MFYSESLLSKTGPLARVWLSANIERKLSKNHVLQTNVKDSVDAIVTPNQAPLALRLTGQLLLGVARIYRRKAIYLLDDCNEALIKIKMAFRTSGNNDMTEGLHIPSRDALMLPDVLTEGDDLEIPLLPDASFLLSQTDDDPNTRKKRAGSRDINLHEDFSSQFMQSSIEITEEILEPMDELDLGLDLGFDLDSSSKNDHSIEIGRNISVARDIEDDLMSKMDIQVPAKGTLELSDRDASLKIEFGNDNTQIIDEVIRVEDTDLDVEMYKGDQPDLTLSSVPLLQPERISESPLSDLDETVTAAEVIHEQSLPEPTQIDPEGLEKQIQETFIRKPAQRAKSHRKLHPDSTIELSTAQIKSQQNNRDKILQPRTFVPRDQGLLALLQMQKRGEFISNVIRGGLSEKWAPELREIFSLNAIQNLKRKQLHDTDILEKDVEDEQRHSPRPRLQLPSEDIEQTSASDSANVDNLFREEINSDPMPQDQTIIELASDREVQISGYDDDQEVATSLEQAHSPTEIHTSTQPLADPKYISIGAKNAVNLLREHFDSEDKSVKSVLFEELLPFSSVTRADATKFFFEILVLGTKNAVKAEQSQSVLGGSITISPKDGLWNASAEKEAGGEQDEASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZL3</accession>
    <name>A0A0B1NZL3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative not2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005579">
        <property type="protein sequence ID" value="KHJ30029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZL3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZL3"/>
    <dbReference type="HOGENOM" id="CLU_032319_1_0_1"/>
    <dbReference type="OMA" id="RGVYLLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="370"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="502" mass="54938" checksum="03E0435EF69B4F03" modified="2015-03-04" version="1">MNRSATGPQTMRPLPNGFPSQPQIIPNRSVSSRIPPGSKMAANNATWAFGGGIPMGNAGLVGLRPSPMTGFGQTIGGSSLPSTPLDLSEFPSLSDNQPQQSQSAWVTSGARTSQNIRIQQQPSISTQQQDDLFSSSSQASNSNQGGFIFSSQNTGSQVSQTQNTEDFPPLSHNNNGEIGHDRGSNLNQNIGFPAQSSGLGFTAPSVTLSTRSNGLLNAISNSSRANSSNAAASRNIPSESLTGVSNSRSFNEPNLNELQDQDSTTHTNTKPGSQELSAHALISRQDVTHHSSLSSKHPPNIDSNLQINLEESKTSEAQDILSSMSEIDRWGLKGFSMMMNNFPAYAALVTGTDLTSFGFDLSASDLLSNQIYSLWDNDPPRPVLSSYKLPECYTVSNVAQLDTKMANFNDEALIFMFYSSPGDLQQVMAAQELHNRNWRYHKKLQLWLTKDEMMVPQSTGNGTERGYYIFFDIKNWQRERRELTLVYDDLESQNFTDHYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM7</accession>
    <name>A0A0B1NZM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002893">
        <property type="protein sequence ID" value="KHJ31433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZM7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZM7"/>
    <dbReference type="HOGENOM" id="CLU_552303_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42023:SF1">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="55584" checksum="641CB6B410C22B81" modified="2015-03-04" version="1">MEPASRNFRGDTAFAERQKLNHVTRTARTLSPKRDNTENRSFRQAIDPRWDPFSGEITSSDKGKPQSVKPKTFGISLRQVDGRKGTTSDFKTPTPVVERIRKLNSRPSVETLEGRSPSFISSSTTAFVSNVEILTPETSSGPEVDIEIRPQSRPGLVTQKSNSTMGKIPVQNSETRNQVPKFMSSDKDLANSTHEKSSTYNKYEAGADTKKEENTIISSDTFSPKSAKVEDKLSSKEPRPSIESNSTSQLLITELEFPKNHIRSSPPVTSENTDHAVQAPSPNNLNINSSIDAKKLTRMSNHKVDKPLIKTNAPVQQDAIVINRVRPSDLSPKLHRITRKAVPPGSPIFISMSIPPNMNANERHLLTKTLPLTPAENSSNDLVTVLQAHLDSLAHRRRNITRSIRQMTELMPRDNLLITDEVRLKREHEKRKVAMLREEEAEIKREEHEVGLRLHRAWKRTESGAVYEPTSLWVRRVTGVGKNWSWPNQDLPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW5</accession>
    <name>A0A0B1NZW5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004823">
        <property type="protein sequence ID" value="KHJ30196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW5"/>
    <dbReference type="HOGENOM" id="CLU_046750_0_0_1"/>
    <dbReference type="OMA" id="HIEGAFA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="51403" checksum="7778CAA55EEC6FFB" modified="2015-03-04" version="1">MAGVEAGATQAIGKNVVQTSENGKIHSSQVAIEKIGDVLKKMKGCLNKVGLKGVIMTVEEVDEAIEALNNNRFIWLHATQNNSLEHRMLALEEAVKKNLVEKCGQMGSKDVVGKSYASVVAPPAAKAAVRIRVPGAEELQPAELLSIAKQKIKGAYAIRQMRSHDTEVFVQSSNHRNAALSMEQPKEFKILRKDFPVEIAGVPLSTKIASGKNADNTELISSLTNASKVRIPGLQINRIRWLQDGKEHEKARKKGHTRGSVILSLPTEELQWRVVRNGIVIDSILYSAQIWTPKAQTKQCFNCSQWGHVQAVCSKLVRCGECAGQHQSCDCPKDRILCCNCGQNHRSWQRAVCKTFKVYKEGVERARLENQIKTAEIRSEKIPATEAKYVPVNTSDEEGFTLVTRKSSETKRGLGRPRKDALAPMTSQIIATSPNAKVGIPPRSSRLSNVRANVENIVALTSAPFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P050</accession>
    <name>A0A0B1P050_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004597">
        <property type="protein sequence ID" value="KHJ30271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P050"/>
    <dbReference type="HOGENOM" id="CLU_1972103_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14630" checksum="1005F695F69D3ADF" modified="2015-03-04" version="1">MDKNRSRSPSSRARGSQCYQCKSEEHRVDTCPYVGPAKKWAYRQRLQDEKQDENYKRQPTLSNSAQNRPHMRERHVHFNSSSTAGKAYTAHDDNDESLEDSPSSDQTDSEIEEECMMAHGVEPSMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0B1</accession>
    <name>A0A0B1P0B1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gata transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004615">
        <property type="protein sequence ID" value="KHJ30264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0B1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0B1"/>
    <dbReference type="HOGENOM" id="CLU_294395_0_0_1"/>
    <dbReference type="OMA" id="VMQSEYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1186" mass="131983" checksum="B541E27D7F988EB0" modified="2015-03-04" version="1">MKLKVLYTFDVENQRNHLARWPEVLSIKKYIINETTTIGVVELQTCLRAIVQASPEIISGASQDYTIYAHDFSECDFPLVGQGLLSNNLKFSSSSPTACPDKPKPLLTGRISNDVNCIFTSGIKETLEVKMRLVPMTSYERRQIDVTCKCKQLSCTASSSTESIEWNPIVPRGLDCGANSILPKNSANFQQEIESNQNINSFTSNSKFQKTKCSTTSHNGTTEDSGNESTETLKITRKSTKTSKSSSKRSRSNISRASIVGGCASSYEEVTEGEEAIAPKKRAKVQKIQRSRKSTFVPNPDSLRVAVGTSDSMRLFKPIAKENILKDLAVAPKENKSRVPTPAPYLSEEQENISAKPRLKLKLRRDSDLSYNSSRPIGKLEDQLHYSTASMDATPERSRSPFDTDTPPGMTSSPPVIKVRSPTRMISSPTCPSSPCLPQLPRLDSGLMGGSYKKPSTDVDTNIFGERILENKMKKVKKIQKRRDSLTTNSALKQGQKEFIIEEECPGPMDQLPTKMPIFRQQARARCATLRNKSIMSDDIQFSLSNQKDRNPSCKLKHKNQSEKHISTDIEDEVEPTQSEKRSMISTKIWPTSQAIVPITSKPPISRIAISASDPILPQNNIHYPQNMHGKLNSFEVQKTKYPSSIQPSSVQSFNGQNTATNSQSSSKKEMIKLKLETAIANGEMPPFCCNCGAIETPTWRKAWSKEMKGEPGYYEYSDEPGRVTAIIILTRDSEGKPTSYNLIKKYLGKDENQDDYNDYLLCNPCGIWMSKYKTSRPEERWESSSEKTSKAEPKKRPTQRVSRPKKSQNSLLPTPASEASYFPSDGPSVLNDTTKFTERVVPEEINKTSISLSTQNKPRSIRFLGTLANKSLDSSCSTIPSAIQSSPVRSIGTLESPIDLEDDLGNIRRLLFSSPQKSEATKILGEAVTNSATKSKRVTSTNETQTITIEKENLSPKNIVEENIDAQILQLFEEELPEEDKQRHKTPTQKSLAAGAEDQFKTPTCPSPTSRMITRSMSKSARSTKSSRKLIEFCQTPVSVKQRQTPKSDEIFESPFTTTLNQLISDAKKPNSPVSNADFASISTFPELVCANLDINMDFSVEDFFSTDLLDSNTCPTNFSDLGFNANSLDSITADITWQDLDFSNYNTADALSIGSVNRPNTLPELKEQMILENRDEDTVVTTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C9</accession>
    <name>A0A0B1P0C9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative allergen asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002647">
        <property type="protein sequence ID" value="KHJ31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C9"/>
    <dbReference type="HOGENOM" id="CLU_748402_0_0_1"/>
    <dbReference type="OMA" id="TWGEAQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079620" evidence="2">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="370" mass="39648" checksum="B4E1A02D384C7224" modified="2015-03-04" version="1">MHYTITVPIVLALFTGREAFCGPTHNHLHRRIHQKRELNNVNWNALDWDGMGINWAAAYAEGQSAPKPTPSIASVQDSIPLPSTAVPEPAVNPEPPVRAEPAAVLTSHAPEKDINEVSEKDSQPLGDSKPDHKVKPHHEPNSSDKPKSGSSKHGSSSKSWKNLVGASNNRKVFGMSTPTYGKEVGYVSNVGIPEGSNMIKVETASDHTFTNQFINISQEPMTVVIWNKAASPGLRDPMNADPNLGASIAPEHPALTIALEPNESQTVAFLDESVIGWAQACETRAISGGFQTTWGEAQFNTTGSGYDVSAIQNAEGSNYIMHISSIEASSCESTESTNMWITDTSTVGSGSCYIAQNTAHLITKMGGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0D7</accession>
    <name>A0A0B1P0D7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RfeD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004436">
        <property type="protein sequence ID" value="KHJ30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0D7"/>
    <dbReference type="HOGENOM" id="CLU_029950_0_0_1"/>
    <dbReference type="OMA" id="QIYCASC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="46329" checksum="63BEB4F807CBB1D8" modified="2015-03-04" version="1">MQEHIRRAHPEKYIPKLPATEESFRLMITSKISERPHSVIKCDLSPESRDSELKNQFREFSSSPNTPVHNLKASEESHTKSISSTDSATPAALSHLQNHSFDSESKLERGWSSDIEVHRQAMRHSLEFSTPKIGNYDIRSDTFSPLGRRGELLPSILSTPQFERSSTLPPIQRIPSVNRPRKESLSKRAREPQHKRNRSKCENVNLWKVNFDRKAQSTESLSSISVGWGKRWEDLIDAATSATKDTDEDNRQKSVPIAESVFNNKEPTNKQGMPLTSLNRDSLPVLATTQSYYEGYQVSPLQQTLTPPKNSRDISDTVKLMVNGETYKDHKFEANGHPGSSLGFTSRSLQIYCAACHGLSLLGQSYACTECICGICETCVDALMANYGARRKCPKCATIGGRYKKINLEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H7</accession>
    <name>A0A0B1P0H7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g5948</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01004571">
        <property type="protein sequence ID" value="KHJ30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P0H7"/>
    <dbReference type="HOGENOM" id="CLU_000846_5_0_1"/>
    <dbReference type="OMA" id="VSENEMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1322"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1372"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1406"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1434"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1481"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1258"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1575"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1634" mass="185433" checksum="6BB0ABA42A831DF5" modified="2015-03-04" version="1">MRDSNLLDKDSPRVRFSKELDNRESISEEIPTRVPGPSKSPNNTSENKPGNVFKPISILLKKSTSSNRPVRNSSASRTRERGYSLRKLILNRNRKHRLSEDDSTILSEILPPQVVQKDLSKTESETSKEAERHNRISPRENDFKTSQIGSNTWGGLGDSKSLAMRKDGGRRKNILMNLIQNSLIGQLWLRDSSLFSKVNQWRKETLKRLLGPTDIPPSKNGRRIKIDATRISPLIDERTGTEYFGNTIRSSRYTLFNFFPRQLFFQFSKLANAYFLLVSIFQLIPGLSTTGTYTTIGPLLFFVAISMGKEGYDDVRRYKLDQIENARKTFVLQASKSGETPIPKRSYWNGGWLALGQNNTEPSVGSCSDSVAQSETSPCWMTQKWKDVKVGDIVKLQRNDHIPSDIVLLHAEGQNGVAYIETMALDGETNLKSKQAPSILAKKYKTIDEIVTCRAQIVAEDPNIDLYNFEGHLIIDDEMLPLTCNEIILRGSILRNTSAVIGIVINTGEECKIRMNANKNPRIKAPELQKITNQIVVILVLFVLSLTVFCTIAYQIWSATTENKGFYLDQVHINIARIFIGFFILYNTLIPLSLYVSLEVIKVGQMLLMNDVDIYDPVSDTPMVVNTTTILENLGQVNYIFSDKTGTLTENVMRFRKLSVAGYAWLHDFDLQKEAKLSEQNHEIEDFLESNKDGSRSQMVKMLKIQTKGFRSSDMNASTYTDPDSIHRSSSIWRSTAQPYKTSNTTNYRTEELLRFMQYKPHSVFTKRARLFLLSLALCHTCLPEVQENGEIEFQSASPDELALIKAAQDLEWLVIDRTARSITLTYPGELNFSTKVTEAYQILDVIEFSSKRKRMSIIVRFPDGKLCIFCKGADSIILPKLKNAPLAIQKKSEVFRRASQRKSIEAERALRITSEWSPTMLSFRHSSQNLSRRRSTGQTRTSMAKKYLQPIRDDLDTWLRQREQSRVDVTACDLDANAYLSSRTSTYGHSLSSSCTSINDKNSLENLISDSVILNEAVILERCFQHIDDFASEGLRTLLFGYRFFDEKEYISWKKIYTDATTSLVDRQTLIEKAGDLIEYDFELSGATAIEDKLQKGVPETIDKLRRANIKIWMLTGDKRETAINIAYSARLCKSYSEIIILDYEKGNVNMVVSNALSDIKKGTLAHTVIVVDGQTLSEIDNNDFLALQFFDLVVLADSVICCRASPSQKASLVKRVRIKVVNSTTLAIGDGANDIAMILEAHVGIGISGKEGLQAARISDYSIAQFRFLQKLLLVHGRWNYIRTGKYILGTFWKELVFYLLQALYQRWAGYTGTSLFESTSLTFFNTLFTSLSVVIIGIFEQDLSATTLLAVPELYIQGQRNEGFNIKKYIGWMFMAVIESMIIFFTMFGLFGSATFNKDDNLLSLGTLCFTVTLIFINTKLLIFEMYNKTFLSIGAWAITIMGWFLWQILLSGVFKPGNIYPLYPIKDGFLHDFGANILWWTVVTLGIACLVILELGVSSIRKTFFPTDVDIFQELQRDALIHKRFEDTLQAELDGDITGVEMGREKTTMELKGGAEVEALLDQPRFMSYEETNSKPRYRKPPVNNSLTTGDMMINKNFTKVESMTTDTEMTRRQTLMRHSIDIAELMRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I1</accession>
    <name>A0A0B1P0I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002277">
        <property type="protein sequence ID" value="KHJ32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I1"/>
    <dbReference type="HOGENOM" id="CLU_2122888_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="12647" checksum="228B0F3AF80AFD22" modified="2015-03-04" version="1">MTDSMDISQDSQAPSTERSQQPPPISPNHNPSPSIASPSPPSITSADSRQMFKPVASSKLPIPERPLHNSRNHSDIANAFIPKELAEIIATRQRRECAWYPQKEEAVALMAYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J9</accession>
    <name>A0A0B1P0J9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004481">
        <property type="protein sequence ID" value="KHJ30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J9"/>
    <dbReference type="HOGENOM" id="CLU_2833070_0_0_1"/>
    <dbReference type="OrthoDB" id="10534179at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="66" mass="7984" checksum="477FDAE5FE0FBC03" modified="2015-03-04" version="1">MGNRVYLWCVWIYSEYHDEALIEGFQKDFAEWTSQIFDVAGRLQLRDIRDYMRHNGVFIENRPGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T3</accession>
    <name>A0A0B1P0T3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0T3"/>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="89" mass="10248" checksum="5263F5CA8FF8CF84" modified="2015-03-04" version="1">MEGLTSSEQKELQTRMERKQMKEFMGMFSNLVSHCFDACIDDFTTKSLIQRETGCVNRCVQKFMAGSERIGQRFGEQQAQMMNNTPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V7</accession>
    <name>A0A0B1P0V7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002539">
        <property type="protein sequence ID" value="KHJ31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0V7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0V7"/>
    <dbReference type="HOGENOM" id="CLU_416305_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="659" mass="75249" checksum="81F93584B71C6849" modified="2015-03-04" version="1">MSSQISKRNKLSPEEKMRLDSAVDWILDPNSINPNTGKASTAGEACDRYQLDVRRRTTIHMRVKVARERGQAVKNGGQNQMLSDVHEKIVCEYITKLSSPGQLGATKQLTYKTISYLLSQESPPRDPPSTSWFSKWWKNRKDDLGLHVIKTKPMAQTRLESHTDRSIRVWFIDNRKWCRILNIKKSKRVWNMDETGARIRCPTGETVVVPAHVHELYTGSPENGLSITVIKTISTGGNYQPPFIILPGEKLMDNWCHENVENDTWATTSPTGYISSQAMLEYLKYFVKFSDSGPNKPWAIHIYLQIFPSHGTHALQPLDVGIFRKWKHQQNRYINMAIRQYDFKYSLSSFFRNVSEFRKHALKSIPSKIIFSKPGIWPISFKKALRSRARYMGQIRRQNEKAQPQRIGKRKEVEAELDEPELPRQLEHLHPRPTTNFEAAKIIEEICKCDTLEPPSSPGTYKESLSIAHDLLIKADLQADTLQNYESAMMAERQCQTSTRKSVHKGGGINVGQWKTKIESRNAKREYLKTLGTSPPCPIIMKTFREPDKDETCRTVDEVASLLPPPDLQQTLNILKEDIELRWGYIDMTGEIEDIQIVTGTMYPNPVDSPVESECEGDDLNQGHLSDDGESVVSSIASSFRSYSSIDFAADYIELINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P114</accession>
    <name>A0A0B1P114_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004082">
        <property type="protein sequence ID" value="KHJ30519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P114"/>
    <dbReference type="HOGENOM" id="CLU_1653449_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="170" mass="18988" checksum="4F58E87220663150" modified="2015-03-04" version="1">MPQEKQSTWATVVRKGQKKVRVITPQVPVTPYISRDNQRSTLPKQGRSTNIQQNATGADKFAPTDSKDKGIFLRVPQEHEWRKLSPAGIREVLIKKLAISPASIGRIKPINSGFALSPSNNDARELIMKAEHGLFLPGTKLELATNYEPVIIPTVPACIHPNRRRPVRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P122</accession>
    <name>A0A0B1P122_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003868">
        <property type="protein sequence ID" value="KHJ30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P122"/>
    <dbReference type="STRING" id="52586.A0A0B1P122"/>
    <dbReference type="HOGENOM" id="CLU_062495_1_0_1"/>
    <dbReference type="OMA" id="DNWRIGR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="30269" checksum="DDAC7DD968A9E024" modified="2015-03-04" version="1">MPLQRLLPPLRASYANIAVAINHKGPIFEIFGKTDTKSINLGLNFVRYASHNQQSSHHQKKDGPGKRLGAKKSGEEYVIPGNIIFRQRGTHWFPGENVGMGRDHTIFSKVHGYVKYYKDPLKHPKRQYIGVALERDHVLPYNPTMPRHRRLNMVTEKMDEKELQILIGPEKTHEIQRKLKSNCRKTNQNLSLRPGYMYRESNWEIGRAAEKANVSVQPFKPRDRWEAWRKTVQRKLRNAEKRAGRMKKSKAKSKSKVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P192</accession>
    <name>A0A0B1P192_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003910">
        <property type="protein sequence ID" value="KHJ30594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P192"/>
    <dbReference type="STRING" id="52586.A0A0B1P192"/>
    <dbReference type="HOGENOM" id="CLU_422766_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="543" mass="62630" checksum="B78E1DE910DE8AFE" modified="2015-03-04" version="1">MAETNPTIPSIEFIPWTEVQVNSATASDVTDYINERIHEYEDENLYGSELHGYFVADFQKFTGFSSKKNVFIQKSRGQSIPAALIDALLDQWCSMPDEMINEVLEKYRPINNLKALRNSKTFPNNPTSSHNPVITLMKAYTEEQKYAGTPSESFDLKYKIFTDFCNTIDIPINKRNGAFKVMLKDAALQHYHATFNSENPPDLSTLYQTIKSNFEGKEYQQSMLVKWNEMSLKTVLKDIESSDVEIALNTLITNLRQIQMSLSPEFQSDKFLFAKILQACRTYPSCSIACSTVMDDTVATLTNRLRSNISTWKSQQNFAIEQYIEHNDGEANIHFTDRRYKRNQRTERQRKICFVCRKEGCWSTRHSDSERNQARKRLTDAYTLNDPPYNRNNNRRFVAETNFDESTIDAFIQQYEGINPDNDRSLVYAFDTFLTIKQDSDNKTNYIINQFFHTQCGMLDFTLAQNTAQQINTGITRYPLTEQVENLEIDNDTFAISKPRFNSDVFYGILIDTGAAGKSTAGYKQFQAFSKPLAQHRLINQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1E5</accession>
    <name>A0A0B1P1E5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="JNVN01003822">
        <property type="protein sequence ID" value="KHJ30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1E5"/>
    <dbReference type="SMR" id="A0A0B1P1E5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1E5"/>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ30644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="477" mass="55254" checksum="4FE3773EC8FC9F0C" modified="2015-03-04" version="1">MDDYLAEWSTNSNNAIQVSLVIPDKGGPKAIHTFKPKMTAPLFGEDEIISGYQGLRINLRFHACDMRPGLKISFSKRMKPDSEYSPTDLKEIFENYLPRSSFEKSTVFDSAIQDQSFSNWKPPGELWKTIQSGNRTFEVWKGNLADLTIQQMLKRIQILVSFFIEGGTPIELKDPEWSLQRWTVFFLYQKQAFESNISPYVFMGYSTVYQYFFVQAKKKGPLSKSHDITLPLPAIHFSSLPCRSRISQFIVLPPFQGKGNGSIFYNAIYDYYLKESRTIEITVEDPNEAFDDLRDLNDLARLRMIPEFMKLKLNKSAVITRTARVPGDIIDPTELEDIRKTVKIAPRQFSRLVEMQFLSGLPEDVRSDTKMGNFSKSESLEDKDKKHEYRLWKLLVKARLFHHNRDTLIQLDFLERIEKLDQTLWNVERDYERLLKAFETRSNPKVVESSSNSKNPKRLGSTEPADGEPIVKRAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1G1</accession>
    <name>A0A0B1P1G1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative sun domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002365">
        <property type="protein sequence ID" value="KHJ32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1G1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1G1"/>
    <dbReference type="HOGENOM" id="CLU_033459_1_0_1"/>
    <dbReference type="OMA" id="SIMNMDA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079646" evidence="11">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="44358" checksum="9FAAA76125E3FE44" modified="2015-03-04" version="1">MRFSCIVFLYILEVVIAQPHNHFHNHHARNGVSDRVRIKTSSVTVEAAVVTVYELNGQKISSSQVDACLKESKCVIVGTKVTAVPSANAAGQPLTTIQAPSLSPSPTKSSLKTNAPVVSPTAITTAALNNEVVDQNRNKELAAVNTNFPSGTIDCSEFPSAYGAVAADWVGLGGWTGVQKTPGYSLSSKSISYIQTAVAGEGCTPGSFCSYSCPAGYQKSQWPAAQGTSGQSIGGLYCNSNGKLELSRSSYKQICTPGVGNIQIKNLHDKNVAVCRTDYPGTEAETVALNALPGSTVRVTCPDAKDYYRTWEGSPTSAQYYINPSGFDVEEACNWGTPGSNSGNWAPVNMGVGKADSGTTFVSLFPNVPTNTNGVLDYNIDITGDVTGQCSYKNGKYYKDGVLSPTGCTVGVNGKAIFVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1G8</accession>
    <name>A0A0B1P1G8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002060">
        <property type="protein sequence ID" value="KHJ32472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1G8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1G8"/>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="226" mass="25406" checksum="A5612B8B13D2D5A7" modified="2015-03-04" version="1">MSGIWSWFGGQSAQKRKDAPKNAILGLRSQLEMLQKRERHLQNQMDEQDTIARKNATTNKTAAKSALRRKKQFEHSLEQTTAQVATLEQQIYSIEAANINRETLAAMERAGEAMQQIHGKLNIDKVDETMEKLREQHALGEEIAQAITSAPIGEPIDEAEIEDELAELEQEQLDNKMLGTGTIPVSDYVHKLPVASSSEIKGKSHAQTEEDDEEEELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1T8</accession>
    <name>A0A0B1P1T8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001943">
        <property type="protein sequence ID" value="KHJ32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1T8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1T8"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="13136" checksum="007EA40C7E7C0A53" modified="2015-03-04" version="1">MSHGFDVACVLKHSLDKILEHNISIVICIDSLSLYECLVKLGNTHEKRLMIDISAIRQAYERREIAEIIWITGESNPADAMTKNRANEALNQIIDTNKLNLRAAAWVEREYNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1V0</accession>
    <name>A0A0B1P1V0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative caf1 family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001937">
        <property type="protein sequence ID" value="KHJ32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1V0"/>
    <dbReference type="HOGENOM" id="CLU_022380_0_0_1"/>
    <dbReference type="OMA" id="LTTCHED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="565" mass="65292" checksum="B4751F7B75D28774" modified="2015-03-04" version="1">MEICQSNFYKNLLDILVNISRASYVTFDFEMSGITTRPKNSPGDRSLDVEKPTLQQQYDEVRSTAETFQILQMGITIVEEVRDKEFYIARPYNFDLSPLSYGGIDIGLQRTIRFNSSSCDFLHSNGFDFGKVFRTGVPYLSRAEESELRSEFELRAERNSKIPDLIIEDADKKASEFCDYIRNTITDWLEKPVQKYVNIGTTDNKLTGFQRRLVHQIVRRDFPNLRTYNRCDGDFMQIEKLNVEQEAIHRKFRLKKFDTKLLKQKGLGWIFEALCGGNLTGIDPLWVYNQQDEEPEKLPAGIATRITDVEAKLKLRNHIIVGHNIFMDLAFLYKTFVGPLPSQVEDFRKEIHRLFPRVIDTKFLATHGLESKYIRSSLKEVLEPFLKVDNPLILLHQDHRFYGSSFGKDHEAGYDSWMTAELFVKLSAKLMTDQKMNGKTIKAEKLLNNHYETCQKIANNDDETNINSYDTSNGIFPTQRAECTKNPYVSSNPFAILGIIEDEQDTALTETPTIQKWLPDFSSKFWTPYINKIRVSSIESCIFDLAQLDVKEYGDQLSKKICTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Y2</accession>
    <name>A0A0B1P1Y2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002213">
        <property type="protein sequence ID" value="KHJ32273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Y2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Y2"/>
    <dbReference type="HOGENOM" id="CLU_012260_3_0_1"/>
    <dbReference type="OMA" id="EFYNTTQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="698" mass="78019" checksum="A84EE092C8844AB4" modified="2015-03-04" version="1">MPFAIEDSPKSKTASISSMVKDDDMEPIKKIIESKSMEQHQLDTPPSEPSDSFDASNFFDLKPPPPPTETQESQVEEIMKRLYSEEHLHYVLGDQSLFQRFLSFLNRYRPNLVPTLTRYMEMRKAMKAVEYANAVARMIQWPSQTDYYKFSRIDAAQTDVRFEDYAIREVNILISEALPAWITYLIVNVVSDCVTRDITGHLLPVIKELVGTLGEVFCISDPSQKENPIIYCSQEFYRTTQYGTSLAINRNCRFLQGPQTDKNTTSRIAKAIANGQETNEILLNYRRDGTPFANLLMVSPLYDDKGIVRYFVGAQVDVTGLILDGLGLESFRCLLQKHSKKVTAPTSRPPSRGRTPSQSGTPTPYSQGNVKKMNESLIKLTDLSMMLSPDESEVVTKNTRPVTPPLPDNESVTSDGCSIRSMLPTNKVPRPIRRIVDSKDSEINNYSITLQRNGQAPARSFPGIYRHYLLVRPYPSLQIIFACPSLRLPGLLRTPLFTKIGGPSSVLSALEEAFRDGVSVTARVLWLPKHGYPANAKARRRWIRCTPLLGSDDSIGVWMVILVPADSEDDVGRPIYDSGYHSLGGPDCLLGLNRYGTGRNSNSDQLFDDNDDLTAIESLVEGRRNSPLDSNSNSSRLRRVTILDHDGDSIHKSESSFGIGSSSENGITSLGRRGTDDRIYGQFLANTTSNSTIIEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Z6</accession>
    <name>A0A0B1P1Z6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003009">
        <property type="protein sequence ID" value="KHJ31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Z6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Z6"/>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="734"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124519" checksum="96D20D2DDFCD69A0" modified="2015-03-04" version="1">MINIHKRTLFLSTNDSSTISKFPEYTDLLESTPRNIYSSNGSSDIINSGLSDSESMPPDDDLLINQVTITPRQESFSEPVHDDAFHGKGMRILRSQTVGYVAPIFMGKRVQKDDVKKQIEVGGLIPASVVDNEIAWFYEELGIDDVYFQSETVEEISRLIISLYAAKITAWAHKEKRQEIRLDMEAADHAIYIDTSEPGVSKSDGSRYEQRLESKYLDVSASSDICYRVETFRSTTSLPRMYESNSTMRCYFVYQCRFVNPSPSPQETCLELIGDRMFLAKATKNTLQIYQDVIKSAVSRTGPVIETFNVENSNKIRLVIAFRRRTALGIFSALSDLYHYYGITSSRKYVEQFSNGITIISLYLKPSSNLDPTKFPPLDVSIRHIRNEISLLYCLPQNRFHSLYVNGQLSLQETIYAHCLMIFVQHFLNRLGSEYSSLVSALDPSNGIHVEILTKIKRRLRTETFTADYITEIIKAQTDLIRPLYSSFASIHLTRFRDPQEESSPHSPMPEPYTEKQLRELIAKSCQNEHEELVMNSFLTFNNSVLKTNFYTTTKVALSFRLNPSFLPEIEYPQPLYGMFLVIGSEFRGFHLRFRDIARGGIRIVKSRNREAYSINARRLFDENYGLANTQQRKNKDIPESGSKGVILLDAQHQDKSSVAFEKYIDSILDLLIPAKSPGFKDPITDLYGKQEILFMGPDENTADLVDWATEHARKRGAIWWKSFFTGKSPKLGGIPHDAYGMTTLSVREYVCGIYRKLGLDPTKVRKMQTGGPDGDLGSNEILLSSEMYTSIVDGSGVLVDPNGIDHEELVNLAKKRQMISHFDMSKLSKDGYRVLIDENNVVLPSGEIVNNGTTFRNTFHLRVDNMTDCFVPCGGRPEAIDLSNLNKIICNGKSTIPYIVEGANLFITQDAKIRLENAGCILFKDASANKGGVTSSSLEVLASLSFDDKEFEENMCVDQDGNAPSFYKAYVEEVQEKIKENARLEFEAIWRESIATKTPKSILSDSLSIAITKLDEELQQTELWNDHELRTSVLRDALPKLLLSKIGLDLIIQRVPDNYLRAIFGSYLASRFIYQFGTSPSQFAFFDFMSKRFLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P211</accession>
    <name>A0A0B1P211_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003407">
        <property type="protein sequence ID" value="KHJ30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P211"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="39504" checksum="F4A075042BBD33D3" modified="2015-03-04" version="1">MAPPAREKRRGVPETLDPKSRVQKSVNNTERAQLLAAALTRSIAKANAVAEKLATVQGEQVVTPQSENPSPPKMNIDTASELDLESEIESESEIDEFPPLPSDPSLKRTLEALSPTQGSDYTKDNLKVNHRSQNSTLMTKARGLLNLVGPYLEEMETDCPGAGAGFLALISEGVFRAIRGETIYLKTSTNTEIMPNSSANKKNSWASRVANVQTSIVNNLTRKPRTKPTPPEGQSHEDRRVMIRLEHNHEARKTEPFLLRQQLQRILPDPSPVADTMQVPSGIAILAPTPAKAAAILQYRDVIAQRFGKAIVERQESWTTFIIGPLPKKVTTMDGKEDTLDGLLLQELGLCHRLKPCVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P246</accession>
    <name>A0A0B1P246_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002940">
        <property type="protein sequence ID" value="KHJ31390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P246"/>
    <dbReference type="STRING" id="52586.A0A0B1P246"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="46891" checksum="1C6A79F91C86C86A" modified="2015-03-04" version="1">MSQRLLICLALYNDYDIFTRDISQAYTQSKSRLARNFYVRPPIELNLPNNLLLKVLLPLYGVPEAGTHWFRTYHNHHTENLNLKQSSYDQCLLFNSQAIVGLQTDDTLIACNQIFKSKESEELKKANFAAKDLKQLTNENLITFNGAHISKLKSSIYVSQKDQIKKMSIIKDVNQSEYVSQRARGAYVSSVCQPQVAFCLSHAAQITHPTLPDVKILNKCLQWQIENSSKGLNFVKLEGKLRLIVFTDSSFANNPDYTSQIGYLIVLADDSDNCNIIHWSSVKCKRITKSVIASELYAMSHGFDVACVLKHSLDKILEHDISIVICIDSLSLYECLVKLGTTHEKRLMIDISAIRQAYERREIAEIIWITGESNPADAMTKSRANDALNQIIDTNKLNLRAAAWVEREDNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P254</accession>
    <name>A0A0B1P254_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002935">
        <property type="protein sequence ID" value="KHJ31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P254"/>
    <dbReference type="HOGENOM" id="CLU_025803_0_0_1"/>
    <dbReference type="OMA" id="GFSQCHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="77885" checksum="74FFD22D75DC7D0B" modified="2015-03-04" version="1">MTTNETFPLPNLAQCEGLTDEQCRKIMSFQDPEGIRAQKGWEPTHQPELIRQYMTMRSFTQIAERMKSKVDWSYKTYSNRYKDWLFPVDRNEREAAVRRLYACIARENESVNLEFNRAASESSFGAQKMQPKRCLRSQNTHDLVPELLGPFSPAESISTTSYGSDTIFDEVYDDYSGRLINSSMWPPLTIYNDTTNFQYPILNPSIAAGPMSQFSDQCQCYHHDLGAESVKHDPKKGLWNATLHVIPCHKDHSSDSWKEQFPPCIGCGFSQCHALMIHARNIDINTFREFLSILRDSAGPDYAGNYPISFLMTAGVRMEYFKAVLWDENWSTFGQNSFSQSPLHVLNPQDLGNELVDLLKLCPHSLSLRDSMCRTLLHYLFLFPLKRENYIRILQNFPNAAHHLQACDTSGKRITEIMQEAADSERALSKNYRDGIKIGLQEIKRFMSSSLVNSAKSQPYSYTDIVRGVYVDFEVDLFSPIYEYSLCLPSTQTKSHFDQMICACNNGGIDRNAPDKNGWTAAHLIVTHIRCSNNSSMKYETPEETEQLFRLLIFNSNLREALHVRDPNGNSLVYNIATRGHSRILKYVLELEDEGRRYSMVNFVGMTKSGQKRSVRESVDVVIANCKWNLNNHCFSTQEQKDRLIQLRYSLIECKRILEQWGADIRPSVEKQRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P267</accession>
    <name>A0A0B1P267_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002143">
        <property type="protein sequence ID" value="KHJ32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P267"/>
    <dbReference type="STRING" id="52586.A0A0B1P267"/>
    <dbReference type="HOGENOM" id="CLU_009400_0_0_1"/>
    <dbReference type="OMA" id="PRPDWAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="887" mass="98723" checksum="6A9D41D825CC0AB1" modified="2015-03-04" version="1">MPQVPSRSVVAHAQEQNNSASVLGADKPKIPSRPSDKRLGRSISPSQENYARSPLTKAPLNLNKDPDGNHHSANYSTRFTDTENCHQLSIRLPSIGQEGTEYADVYISQDENLNKLSLNNKDVNNSDQFLKPGPTNPNSEVKSLASTMDHKDFRKESVIATSNVNNGIDSQVSDSCKNTQGIPQIGLFVPMYPNAGDVQAPSQSLAISTVPDTSTDYNKAESKYFSQRLNGRGQEIPSDAYGRYGHGFISQDLFDKAYYKKHPELFKKEIGSYGEMRPEWALSSEDLNKIVQDTATNGTGIGSSTASFAAPSEQVGFKVSEEYICRISSPKSQPQPHTSHSNITEFQDMTPSVRKLSTTTLNLKVEASRSISQIPEQKNVTLENSQDSDVIHISDPLRSSNEINRAARLSSATDIVEYNTEFEKIDDDHQYKAPILAPDEVAKQPLDRELQPAVFPMNKNIENFREEPIYTPLTTYCNSLSKNLATAEGSPCSTPSIPQEDFNRYEPLFPEEEKASLNDHNPSRSLEILKRFEMSQRFPGQDVWEDTPSSLQYTTTVSAPQLPEEKKINECKELGTETPAQAFARRQEKMAEQGVRDNIFHQEKKNQFESNGQTESKSLFETTNHRFPSRDIWEDTPDSLLLQTTVANTQIEVETSNLDSEQKSTLSRENSKSRKSNGILTTNESLDNRKPENKLNLESTSTIHSTTLDSTISQESSLSSRQEALENIVKNSIKNHTSSVQIKAKPQVPARPARLISSNSSGSLSTCSNPSLEVTGKIKPQIPSRPVGGKIAALQGGFMMDLNKRLQLGPQPSRKEIPKDEYQNVEKDNAPLLDPRKSRARGPVRRAPNKAQLTNSVPTNLPKEKDMGISQTLTIWSYDPELEYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2J2</accession>
    <name>A0A0B1P2J2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003203">
        <property type="protein sequence ID" value="KHJ31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2J2"/>
    <dbReference type="HOGENOM" id="CLU_107277_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19789" checksum="0FEE855B67B7AAA9" modified="2015-03-04" version="1">MLDKVQRAAARAILPVYRTTPSATLYRELGVNPAELTLEHLSRRTIIWTRRLDPFHSLFIKCHRLAFRSPVTRFSRIIRTIPPSELIDPISIPPWERFSTRHRISEDTLDFSNPNSKASKFRNFLKSLPKNDILVFTDGSKLPDGRAGIGYVIFQLDRQISSGSSPLGKNNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D0</accession>
    <name>A0A0B1P3D0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002878">
        <property type="protein sequence ID" value="KHJ31451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3D0"/>
    <dbReference type="HOGENOM" id="CLU_042181_2_1_1"/>
    <dbReference type="OMA" id="HIYLIWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF288">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="42157" checksum="DB42F62CE02798C7" modified="2015-03-04" version="1">MGTVQYVAAAVLLVSFVTFVAFFGRNPLLRKTPVGWLHRVIWFHIPSGLRFIDQKLTHGRISTWVVKQVNHLWNDRHPLVLIFFMLLLGVSEIIFLPPAWPLLSNQRKLLALIVVALPWIFLYASASTDPGYISQTNHVHQMSLYPYDFTIFYPGLFCNTCRFLKPARSKHCSICKRCISKVDHHCIFINNCVGQRNHHYFILLISTTALLTTYATYVGISLLSEDIRKELPSWTIRGRGYSWTQYSGLLSYHLYLIWIGATTNETLKLSELSADMADGYVFKRSLCKGRLKNQRYEPLWTRWPTESSHIITRSFDGQHPDSKIIGSGEWERIWNLSDIPNLYDLGLVNNLRDIFLPGCSFQKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K6</accession>
    <name>A0A0B1P3K6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002484">
        <property type="protein sequence ID" value="KHJ31915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3K6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3K6"/>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="OMA" id="NRDRGTY"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15435" checksum="099E63AB7083095F" modified="2015-03-04" version="1">MASANYREAFALFDKRGTQRVQKESLGDLLRACGQNPTLAEIKELELNAGAEFDFETFSKILNRPGGFRDPGEPGEYCRGFQVFDKDMTGFIGVGQLRYILTNLGEKMSDDEVDELLKAVNVSSGEINYIDLVNTVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M1</accession>
    <name>A0A0B1P3M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002805">
        <property type="protein sequence ID" value="KHJ31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M1"/>
    <dbReference type="HOGENOM" id="CLU_2442503_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="90" mass="10279" checksum="F991936F738849CB" modified="2015-03-04" version="1">MLQALIDLLAVTPCEQASKEAVEQRAVETEILFGPITKTLDHYCFSTTQLPPILARVLRKFCDNVTKEATKHFELRNLDPLPLPRLYPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V8</accession>
    <name>A0A0B1P3V8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative udp-glucose:glycoprotein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0312</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002999">
        <property type="protein sequence ID" value="KHJ31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P3V8"/>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061816" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="278"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="414"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="672"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1471"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1491" mass="169028" checksum="F2C6BD44DBCF37C3" modified="2015-03-04" version="1">MGGLNLALGLFLILLVNVFQDSLFSFASPTIDVELRTAFPAPPFLLELLETAGSENSSSYFPLLDKISDGIFASASTDEELYKKFLKVLLDEGHLADPEAVSSYQLALSLRLSTPRIESHYQYYNTSVETSITPENDSSCSTWFLFQGLKFCSPSLDKASGSASLDLKGDELLFDRVLGNKSAPATILFADITSPKFGAFHKLLAKNARDGKSSYRVRHRKSQTSEFKTLAIPGWGVELALKNTDYIVIDDRNDDNEHDSKTNLPLTEEEIKLKDNEMNDLKPLSTSELSSLAVKASSYIMQSESPLDTLLKLSQDFPRYSQTISSHNISLDFITEFQYNRAQSIEGGRNNIWINGLPLTERQMQIMDLIDIMRKERKIISGMSDIGFTPSEAIKLLLHKEIVSAQTLDGVDRFDWTDKTEGGNVIIWLNNIEKDRRYADWPVSLAAMLQRGYPGQLPFVRRDAFNLVIPIDLTDQLDLELILETALNFVNRRLPIRIGLIPVIRNSNAAIEAKVIYHLIEIYGLQTAIAYLRSQNESKLSLNSKDVFDQITQKAKIKTNKTRIIFDEVLKSDELESRIQSSQKWVDRICADDLVPPVIINGVVIPKDEFWLQKMSQQIYTDLQLIQQTIVLGTENVRSQDFWVPSIFLNQAINRRNKLIIPENRKDLNFFDLNSIEKKSSEFFKDLPRFSASSSVTNSDIIFMILIVDLDSEMGENLLTNAATLYKKSPSIELLILHNPATESKPKLSHGLFNYLENNNLNGLEAVENMTATLYGQQSFHESTKLGESKIYWQKFAPISRLLGLVPGQNAILVNGRLIGPILNSKYLQMEDLELLISFERNRRVTPIFTALKDLKLEDKIQDPLKAAKLSSIIALSTVSEITNSIFGEASSIREDQFSVWRSQYTAIEVGDASTANIQFTVLLDPASHIGQRWASILKVLSKLKGVYLKIFLNPKDRLKELPVKRFYRYVLESEPLFDDTGAIKSLHGSFTGIPQEALLTVGLDIPPAWLVTPKISAHDLDNIKLSSVKTDINAIYELKNILIEGHSREVVGDQPPRGTQLILGTKKNPYIGDTIIMSNLGYFQFKANPGYYSISLQKGRSFDIYHIDSIGASGWSSVPGDDKTEVVLMSFKGATIFPRLSRKPGMEREDVLETRASSEMSFVSQGLKFAQGILSKGTYSPENEASINIFSVASGHLYERMLNIMIVSVMKNTKHSVKFWFIEQFLSSSFKEFIPYLAEEYNFSYEMVTYRWPHWLRAQSEKQREIWGYKILFLDVLFPLSLNKVIFVDSDQIIRADLIELINLDLNGAPYGFTPMCDSRTEMEGFRFWKKGYWAEFLRGLPYHISALYVVDLRRFRQMAAGDRLRQQYHALSADPGSLSNLDQDLPNHMQKVLPIYSLPQEWLWCETWCSDEALKDAKTIDLCNNPLTKEPKLERARRQVPEWTKFDDEIAALDKRRRGSNDLGEKSSKSSSSETIPEIKSTSVKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P419</accession>
    <name>A0A0B1P419_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nuclear cap-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002359">
        <property type="protein sequence ID" value="KHJ32085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P419"/>
    <dbReference type="STRING" id="52586.A0A0B1P419"/>
    <dbReference type="HOGENOM" id="CLU_012062_27_1_1"/>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="153" mass="16732" checksum="DA1E79A415BF4DC1" modified="2015-03-04" version="1">MTDQARWKATIYVGGLSKNVTISDLHAAFIPFGEIADISLPKPEVPNALEPHRGFGYIEFEDPDDTFDAINNMDQAELFGKVIKVNAAKPAKNLNEGLGSKIALWEQEGWLAENVVSEADKIATGRLRPDQEEKKDDPMQGLEGLDVAGPKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4W0</accession>
    <name>A0A0B1P4W0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001266">
        <property type="protein sequence ID" value="KHJ33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4W0"/>
    <dbReference type="HOGENOM" id="CLU_1628278_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="19038" checksum="DEBADD8968DC9CBD" modified="2015-03-04" version="1">MISRRLFEPKESLQNYYQRALDILSRSHCRDEPLASSGDECLNPLEVVFSSGVIISFIEGINDPELRSNVLLKSSNTYRSLHGAYEAVKDTQDSMRKFREIKTRLAEKRELEQFREIYYQGRNVTAASASFNQRYPIDNQNIYQARHISYPNQCYQPPLNIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4W6</accession>
    <name>A0A0B1P4W6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative monothiol glutaredoxin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001265">
        <property type="protein sequence ID" value="KHJ33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4W6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4W6"/>
    <dbReference type="HOGENOM" id="CLU_026126_12_0_1"/>
    <dbReference type="OMA" id="NGPRCGF"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="29046" checksum="9B3FBA2320275113" modified="2015-03-04" version="1">MNMSSLKEIKTKEEWQAYASSIPPTTLQIIYFKTEWAAPCKLMTTVLETLASSYPVTDPLSTSWISVDAEEAIEVSDIFKIAAVPFVILRRDTQIIESISGSDASKVRAAIEKNTNSVQAQPNITEKSSIANVEIKSPSSNSISQDTSVVNDTAGIETKETKEELHKRLAKTVRLHHVMLFMKGTPAAPQCGFSRQIVSLLRERGIKYGFFNILADETVRQGLKEFADWPTYPQLWVNGELVGGLDIVKEEFSNNPDFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4X5</accession>
    <name>A0A0B1P4X5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001530">
        <property type="protein sequence ID" value="KHJ33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4X5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4X5"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="CFDDYPE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="44082" checksum="4391774DA0FAA466" modified="2015-03-04" version="1">MKFTSNVRAIYSFAREKAFMSHHSDNGRPMTMVDILQASKKRHLRKCYKGKLGIQDFILIKILGTGTFARVWLVKLAHPAKEDQDKVYALKVLRKVDVIRLKQVDHVNNERKILADLAGYPFIVNLITSFSDRESLYMLLDYCPGGEVFSHLRKAKRFDEDCVRFYAAEIVLILEYLHESRGVAYRDLKPENILLDEEGHVKLVDFGFGKFIGHRETYTLCGTPEYIAPEVIQSKGHTTAVDWWSFGILLFEFLTGYPPFWHKSNPLDVYKQILNNPIIFPVDVDLSPEAKDIILQLCTVDRTKRLGNIVGGAARVKSHPFFRGVKWENIYVRKCSGPIIPVIRFSGDTQYFDHYPVDKYKKEPYSIDLERKWEHHFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Z6</accession>
    <name>A0A0B1P4Z6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002398">
        <property type="protein sequence ID" value="KHJ32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Z6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Z6"/>
    <dbReference type="HOGENOM" id="CLU_005620_1_1_1"/>
    <dbReference type="OMA" id="WAMTLFN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="799" mass="90762" checksum="43F6297E083CDC35" modified="2015-03-04" version="1">MAFDPSEEHIKLFGEMAPGIPRKEIIRRLKGNNNNVEQALNEYYDNPDTNKYSSFDTPSENELDGSQENHGILFKIQGEDVPSPHGQYHSAPSRPPSRINNNSPLNNIYSSTGHNIGNDLNEQHQDAELTKALALSAQEAGLNSQESGLSATTFGPATREVYDSNQWSMVPLGKMASMDSYTDSEPTFRKREPNAPAFLKPSIQNHFLAALITIYHEIPLMRNIFLKSANVLDVYRYDKQWWMGRSIELGSQVSSDPSCLDIDQELQRLMAFLDDTRRSYGSIEPLANSPTVKAFSRAYYGSDKACAFLEAWRQRNQQNSRLVDQVFSAGVASEDAEQDERQFAILELTTPSHSLYENLYDICDECLWPELQPLDLASSPYLSHIAEVITFKIEAASDHKSIKFPAVWYPDRYLKHSREASLEMRKKKYEILEEIDRISRLENRLTSITSANGNVYSVKDILEVSLKHDEDLLLGNESQDERESKDFTNLDDAVSRKLSAELRKLIKSIDKKLDELGRDKNILSASLRQISTLNTYQSPSPEAPILRPYSLRGLRTTQSTTYICQRINKTEISCSENDPKPPSDQWWRVHYSNDSTGAFTLERTTTQKVLTAASEECINPMLVYASEEALSVPKEPLPESLQKFVMWDNRLFNSELLENARSETDTQKATEFDKSECISGFSACSPSKRKYAYGDLDNVELELNRLERRDSESVLDIEALLPSYEDSHLKLDGNLERKLDEQPLVVGIEPSHGEVNNCIGDIDYEMNCSSPQVNISQTEPTDQMDYIYEKVGKNYDMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P575</accession>
    <name>A0A0B1P575_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P575"/>
    <dbReference type="STRING" id="52586.A0A0B1P575"/>
    <dbReference type="HOGENOM" id="CLU_963759_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37610">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37610:SF40">
        <property type="entry name" value="OS01G0909600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32530" checksum="56CF29F79223384A" modified="2015-03-04" version="1">MTSDQKIDTNQLSTSTNSLALKFDRLPILTGSENYRRWAGSWEIASDAMGLLEVLTGEMPKPEQSSENFKIWKNANKQLRGAILNAVDETLQTVVIDHQTAKEAWDQFKSRYDRETSNSTIDLLKSITNLSLKDGDDISDYLTLFNDSWNRLRNQSSSAKTPLAKAFQDLTSSEDAKGAFLLSSLPKSMKNVVDNPVTKELVSYGDVSAKLLDVSVNRKSSSTDDKAYNANKLEKKECSWCKARKYRFEGHLDTEYRKLKASQQKKKENKVANAAQASKSDNSDLMKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N8</accession>
    <name>A0A0B1P5N8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01002237">
        <property type="protein sequence ID" value="KHJ32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N8"/>
    <dbReference type="SMR" id="A0A0B1P5N8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5N8"/>
    <dbReference type="HOGENOM" id="CLU_073661_0_0_1"/>
    <dbReference type="OMA" id="DHAPNWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="24625" checksum="8806C8FBCD3DE83E" modified="2015-03-04" version="1">MMTILHSPFVTLLGTVIVAGVSGYLIGATSSSRKFFSKTASISSLIPGSRTINDNKIEISGDEDVDFDEELLNHAPDWENDDRSGTQSPSKAPRNKSVETKPSWDTQNQEECKMVLVVRTDLGMTKGKIAAQCSHAAIACYKNMLFSNPTSPSLRKWERQGQAKIALQVKSQDELLTLHAIALSLDVVAEIITDAGRTQIASGSQTVLGIGPAPRSIIDQITGTLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S8</accession>
    <name>A0A0B1P5S8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002394">
        <property type="protein sequence ID" value="KHJ32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S8"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="133" mass="14525" checksum="F3FE1BDFBA53CFEE" modified="2015-03-04" version="1">MVCTSFISNIDSSVSRFKDGDELEMAKSIQAYLRTAISKFAASDTTPPLPEKQLKSNTAKVSENSKAHLPNKPLVIPFPSKISSGQVENVTNSTKDFRSQNPSGLENSWSTIARNGYKKSRTIITSRSQASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X5</accession>
    <name>A0A0B1P5X5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002199">
        <property type="protein sequence ID" value="KHJ32291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X5"/>
    <dbReference type="HOGENOM" id="CLU_2607805_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="79" mass="9134" checksum="B53C785D6BFA4021" modified="2015-03-04" version="1">MTNCDMTQSASPEGSTFGTKKYVGNERRVGLTHPNTIKNKSVFQPRVKNIRSKDISSQEERNLWDEDDPHGMESFPQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X9</accession>
    <name>A0A0B1P5X9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sulfur metabolite repression control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002351">
        <property type="protein sequence ID" value="KHJ32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5X9"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_1_1"/>
    <dbReference type="OMA" id="GIAHVWS"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140299">
        <property type="term" value="F:molecular sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046686">
        <property type="term" value="P:response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="378"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="684" mass="77681" checksum="DAD1BB18941291D8" modified="2015-03-04" version="1">MKAKQSVDNVRHFGIEFKGQYEARQGKGVHEIVRDLNDSTLKSSFDTNNVDQILVDSLNTKQLLSQSVVESHAQSSRDSPKDSNTMYCYRHRPDSMCRRTADEPTMEALSKKVKILPASEQDPIYQVWSLFSKAPAKHRNLMLQGILSQCCFPQLSYLSTTVRDLIRIDFISALPCEIAIKILCFLDTKSLCKSAQVSRKWRKLADDDMVWQRMCEQHIDRKCTQCGWGLPLLERKRLRDWKRQQQLRAIGDKRNLKPHGSLPVPHEEVPETLKSQKTSSKRISLESTSDQIINQFEANKRQRTRAFKPEFRPWKDVYKDRFQIGSNWKYGRCSTKVFKGHSNGVMCLQLEDNILATGSYDLTIKIWNVDTGKCIRTLSGHTAGIRALQFDNQKLISGSLDQTVRIWNWRTGECINAYQAHTAGVIALNFVDNILASGSMDTTVKVWNFEDKSVFVLQGHSDWVNAVRVDADSRTLFSASDDRTVRLWDLDTRQTIQVFEGHVGFVQQVVLLPAGHEFDDIIAANDNDHCNGTCSDMTHEINSHPSTPQTNWHESWPTKRPKPPRYILTGALDSTVRLWDVVSGECLQTLFGHVEGIWAVAGDTLRVVTGAEDKMVKVWDLRTGKCEKTFLGHTGPVTCVGLSDSRMCSGSEDCEVRLYSFKQEEVLAENLSTENNLSIVTQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Z5</accession>
    <name>A0A0B1P5Z5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative carbamoylphosphate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001042">
        <property type="protein sequence ID" value="KHJ34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Z5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Z5"/>
    <dbReference type="HOGENOM" id="CLU_026180_1_0_1"/>
    <dbReference type="OMA" id="CNPRTHS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="210"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="524" mass="60430" checksum="3E8CD380D9675261" modified="2015-03-04" version="1">MNKLEFKKKIVLDNNSQKYPSVIPLKMSILTENASLLNYNLLQCLLLLFNIIFLPYSACITISVLLLNKIGFLKAPRRILENKTPRVLVSGVGMSKGLFVARTMYLGGCDVYGIDFDNKNRNLYFGRFSTSIKRYISVPDPITEGVDEFISQVIEIIKNENINLWVSCTRVATPIDDAKLADAIRKQTNCKSFQFNEEVTSILDNKITFMRKTLELGVSRALWHSLSSYHDINNLLHKIKGSTVSGQAVRFLIKSANLDDSTRNLLPLVSSDNLRDAENVLKSLDFSQNHEWVLQEFIESQEEYCTNALIINGQVRAFTASRGKSVQMHYQPLNPNSILYENMMQFTQKYASALGDITGHMSFDFLVSYQKTRDGFEGKLVPIECNPRCHTVTILFHGKEVELADRYLESLYGKQNTPILETKHRVHVGHYWIAHDLVTLGALPILRLISGLASYSWTDEIQRILQLLEHIVTWKDQTFLWWDPLPWFVMNHLFWPLELYRLYIENIKWRMINVTTGKIFRKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P642</accession>
    <name>A0A0B1P642_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative wd40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001265">
        <property type="protein sequence ID" value="KHJ33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P642"/>
    <dbReference type="HOGENOM" id="CLU_003635_0_0_1"/>
    <dbReference type="OMA" id="YVNPFDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000817">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="7">
        <location>
            <begin position="540"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1356"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1564" mass="174452" checksum="B3245C926B808400" modified="2015-03-04" version="1">MSGNVRSSPGNNSNENSYRMDTLLDQLRLQSRPISLDPIQRYYNNEADGFYGQIKPQPQPQSQSQPLQQPSCDYILQTSPAPSFGRSSHRNSTSNSFIDGSKLRVNSGAINSDRTSSLLNLLKFSTPPSTSTNLQPSASISQNLPISHEASSNFPETDGHTQTGNTQKPGEINLLSTFLNPTSPKLIQQSNSTSLSIRPAFPPESSSPSADTQAYLLQLLNQPKSKLSSENDITPIRKQQNRPSTPQEKLATQGNIADEFSQARAEVTVDVGVIGGLDKGSARKSNKETQKSSSNSKSAPGIFTYVNPFDGLAESSPRNRPQKPEKPTGPINSTFQILKNPRNEISDKQKQGLDNPTSIKLEQDLEATSEEKKDTKSFTIEESKKIEMDNNDATSKTKELEGKIPNIGPKILDSLANISNPGVEKDEGKIQIENKLWEMIALNNEKDSETNVKDNLGLEVKSSEVVANNSHEASSKDDKDLTNKTKNFDMNHVVDSWENVDTEESPIKDGEDVTIKVYNFPMRPWTSITIRETDEPRPYFREKSILDIARLKRDFDQVDRTLVTASAYFIVYGMSKNGGVRIIRQEDGKDAKLFTETHDRIFNVTISTSSIEKKQAVIGTGLSGTVYWVQLKDGDGDRLEDSHLESFGFALPPLQEPDPDALTTALKTRARNSSNNPEFFGVGRGKFIYIVFPSIILEKYILTDGNNRQVNVASYMKHNSLKINTGKAVKDFTFSEDDTTIASLDKAGRIKFWDIRGLTKREISYPSSDLQQTEVKNPIVIFNSTPTIEKSRPTSIIFVDKIRPYQRGGALRYLIIGMMQNHTLQLWDISLGKTVQEINLPHSSDSDAICSVVYHASTGMIVVGHPTRNSIYFLHLSVPKYFLPKTISQAEYLEKLTLGDTTIPKPESTAVISGMREYSFANKGILRSLDILTPDSTNPSDKESLFELYCVHSKGVTCLEIRMADLGWNSEYRAVHPVVAQNINLITINTLREAPSNSQPESNETATQPIIPTRIFPRNSGNGKPIENLKDKIAARIISDETTKPTPKADEKNDKKENQTSNGSLSAPSAPEKVEKKKRRKGPFDNTGTFQNNTYFKMPVIDPSSNVRNIDSIRINSNPVSDVLTQPVSELDLKNVENLFISSLDKLHQDLKIEKQAQNSNLNANHEAMLSLVADTLNDTIENNFAKIVRSSIDSKILPVISDVTSRAIKDQLCLKLDNQLANKLPQELQRILPDAVSKALYQPQILKLITDSLTSTVVLEIQKELNIILANSVIPGISNLISQSIHKISTDVQSRSTDQINIMEQQFHSNSMKIVQLIQLVTGLSETVSSMAAAQTEFQGQFLKMQNQVAQNKFNISRPSDNHSNHQTSRPSTALTSSAERVRVDEEYDNMLKRISISMNTGQYENAVIQWLQTRREQEFFINYFSKYSPDFIRELSPLLLLSLGATITVAFEGDFNHELIIQRIAWLETILATFQAHITAGSIDDQVRDLSPKIMGIYRQRLEHLYMRISQISSQEPILKRISMLVTAANRIVDTARVDERIHEYVGELAGGTPMGIARHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N8</accession>
    <name>A0A0B1P6N8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EV44_g0158</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001953">
        <property type="protein sequence ID" value="KHJ32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N8"/>
    <dbReference type="HOGENOM" id="CLU_010475_0_0_1"/>
    <dbReference type="OMA" id="LEGWMRF"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="23" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="788"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KHJ32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="854" mass="96769" checksum="4C69F1D3300CDE45" modified="2015-03-04" version="1">MPLVVPPRQEFARIVLIIVVIFFLYIAPDSPTSGARSSQDSLLDHTETKNLLGILNSSQWQDFAPRSSKKEAGELQKYINLTGFRENDGYQGWQRLNVWKERCVLFHQEANRRSESKEIQRKNYYTNITGVVWGKWTRYEADLTGLEKKEWPKINLSQVAPNSIYGAETNKTWAKNITGSSGSMMIRINEKDGEDSVIKSIKAEEPSIEPARRITATINLQDETNKGNGWFVRLHGVHWPKKGVLLLTTNSDKFDGIFGLPHLTYSFEQFISSQKLISQFFVMSLQKLEKTSKKDYESSISSVSENEAAQLGPQCEFVVFAQVYPIEINYISKFHFKDSELAIQEIERELRFPKGMPTPKIPKLQISTVILSPDCGFMLESKGPPDFTSEEDEHLIGEKQEVLLKNIHLLLQLFAVLILGQTFLLKAQSKDASTPSTVGRISLYTISIMLFADTFIFASLSLLSGTSPNYFPSALLASFISLMSVMLGIRFVSAIWNSQEPERRERSMQRQATESMTHPLTSEVQTDSHINVTDTNSVITPGVTDSIHDDNPIIIPSDQDIDAEILENNLNSNSSLLPTISPNASSTQTRPQSNNVSFATMYVRSVLLLTLILFVTLTSTSWPVKLRAIYIYTLSLAYLSFPAFQIYRNIQRNYRKALLWRFIIGQSVLRLTPFAYFYLKKDNILFSETDKKAFILLAGWLCIQCVVLAAQNIFGPRWGLPKTWYVEGWNYHPILRMESLEAKGLPIGLVSNQDPSSLINSVNTFLSPASIEQGKQGKKNIRLRCVDCAICMQTLEVPIIEVDKDTTTSSVAGILESKRYMVTPCRHIFHSMCLEGWMRFRLQCPICRENLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P5</accession>
    <name>A0A0B1P6P5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001944">
        <property type="protein sequence ID" value="KHJ32616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P5"/>
    <dbReference type="HOGENOM" id="CLU_115008_0_0_1"/>
    <dbReference type="OMA" id="VESWVDV"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="117" mass="13503" checksum="C71E9D6D8EB2769D" modified="2015-03-04" version="1">MASIFRVLVKTDHMISRKKIDLVKKASQDFPCAVLLKVGGKPGMMFAEGEGAEKWLNVVKKLRYKGFRLQKKELVSSALLDLQPGKVIEFESVRDLAAFLSKRLELYEWWRTHMGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6V8</accession>
    <name>A0A0B1P6V8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4917</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6V8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6V8"/>
    <dbReference type="HOGENOM" id="CLU_003532_2_1_1"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="70"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="230"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1198" mass="138683" checksum="D0D93577080AFD9A" modified="2015-03-04" version="1">MNPIYNTDFESPNDMLVDSDELLNDAENEKDDGNVHDILPDETILRGDDEYAMRELVLPPLLEQPEVLEIKSFSWQITDWTQLPRRHRSPIFWCGGHPWRILMFPKGNNVDYCSVYLEQGYEDGSEVGPVPQNFSCCIQFGFVLYNPDAPTCFTHNTANHRFTKDEGDWGFTRFVELRKLWSVPWDAQNNYLAPNERAILSAYVKHVKDETGVLWHNFQNYDSKQETGYVGLKNQGATCYLNSLLQSLYFTNAFRKAVYQIPTQDEESLTNSAYTLQRLFYQLQTSKCAVGTSELTKSFGWETRHIFEQQDVQELSRKLMERMEEKMKGTEAEKVLPRLFSGKVRTYISCINVNYESHRLEDFWDIQLNVSGNKDLESSFQDYIQVEIMDGENQYMAGDEYKLQDAKKGVIFETFPDVLHLQLKRFQYDVERDAMMKINDRYEFPEIFDASPYLAENADKSEPYIYQLHGVLVHSGDLNAGHYYAFIKPEKDGWFYKYDDDKVTRATMREVLEDNYGGEYLHPKGHIPLRRNKPILRQNNAYMLVYIRQNRLDQVLFPVTEEDTPAHLQIKLDEEARIRDARKKEREEQHLYIVVRVITDVSLREHCGTDLAVINANEWSSPGSAAYYRLLRKSSLQDLIDQVGQDTDVDPRRIRMWVMVGRQNKTIRPDQPIQDANISIEEAYQKMAGHKNGDFKLWAEVAEEVDNEGNAIWPTCPALNANRLPIKSDIIILFLKHFNVQAQQLNCVGYIYMSKEKKVEDLLPFILKKMGWPDKTSNGEKLQLKLFEEIKPTMIEPMKAKQTLKAAELQDGDIICFQLSTNDTKLDETAFVKNNVKSPVNVMNLTDRNASVKLEKSISTLDMARNNYLRLPQDFIDDARSFYDWLANKKDVTFSPHPLRNTNPENLETFTLTLSNKYTYDQMATRVGHYLNVDPTHIRFWTCHSGTGAPKLAVKRTSSQTVNAMLNPAYSSFSNSNQKSDSLFYEILEISLSELDTKKALKVFWLSEGVSKVDEYDILVPKNGCVEDLIQALIKKAQLEDEETGGPFRVYETHNSKIYKVINKDYQVAGITDYVNVVAERIPTEDIEFSEPGNWVYAFHFQNEPSKAHGVPFIFRTIDGERFADTKKRLEKRTGLKGKVFEKIKFAIVTRGSFSKPFYLNDDVIIEEYLAHREDMLGLDHPDRSRAIRNGAGDLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W9</accession>
    <name>A0A0B1P6W9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative heat repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001103">
        <property type="protein sequence ID" value="KHJ34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W9"/>
    <dbReference type="HOGENOM" id="CLU_154777_1_1_1"/>
    <dbReference type="OMA" id="VEMYSSP"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="78" mass="9543" checksum="EC43600F171B893E" modified="2015-03-04" version="1">MRYTGLQREVLLLYRECLRACRKKPSDTRPHFEKFTRAKFDMNLHLNKKEFMTIEYLLRKGRRQLELYSSSEVSDIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P734</accession>
    <name>A0A0B1P734_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002053">
        <property type="protein sequence ID" value="KHJ32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P734"/>
    <dbReference type="SMR" id="A0A0B1P734"/>
    <dbReference type="STRING" id="52586.A0A0B1P734"/>
    <dbReference type="HOGENOM" id="CLU_1373123_0_0_1"/>
    <dbReference type="OrthoDB" id="3597759at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061930" evidence="3">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20785" checksum="6295C70F19C289B9" modified="2015-03-04" version="1">MRFIIGAVVSSLILSPISVLSMAASNDSTEAAAHIINDSILEDVSNVADFDWSSTSYQGLEKRFCFRRGCKEEKLKRTSGFQCKKKYISSEKIERAKAAGCPEIKKNKQRSAFPSLYTASDFAVPGPYLEWPISRNGRFWNKLSKGKYRIIMTKSCKVVGVVIREKKSSYRTCKDLSKEEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P758</accession>
    <name>A0A0B1P758_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cbf nf-y family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001846">
        <property type="protein sequence ID" value="KHJ32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P758"/>
    <dbReference type="STRING" id="52586.A0A0B1P758"/>
    <dbReference type="HOGENOM" id="CLU_2198947_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="108" mass="12077" checksum="A3B5CE957A9FE12C" modified="2015-03-04" version="1">MFIQHLAQLAHSVAKSERKPRRNIQYRDLATAISNHDNLEFLTDVVPHTLTFKQIKEKKASSKSRKPNGAAISETEAGQTLLDISSYHGSTQLKDAADEQDGNLNFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7K7</accession>
    <name>A0A0B1P7K7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor bzip</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000749">
        <property type="protein sequence ID" value="KHJ34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7K7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7K7"/>
    <dbReference type="HOGENOM" id="CLU_1230702_0_0_1"/>
    <dbReference type="OrthoDB" id="3565340at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="225" mass="26039" checksum="C4E0C3F22CFBDF84" modified="2015-03-04" version="1">MNIQNNNCIMRNPKPSNTPRLKYNYEKRARSNKLNEGSSAFSSSANPDEDWTKVKDLAERRRIQNRIAQRNYRKKLKLRMWDLERLAKTSGTPSPGQQQVGLQHQNFPQELLLQEYSLNTEGNRQQVPVLEHHHFPMSLGMRQVYPGLCEQNASGYQPQVYVPEEYLYSSYPQAQNTYLLSPRSEGQSISSFDMNFQDFWSHGVTDSYLHGDQNLFASSSSLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M2</accession>
    <name>A0A0B1P7M2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001711">
        <property type="protein sequence ID" value="KHJ32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7M2"/>
    <dbReference type="HOGENOM" id="CLU_1504544_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="21009" checksum="F4B78451E63BD6F3" modified="2015-03-04" version="1">MLREFWYQFDATKFFDIINLRVSGEALEVIEQNRRDISPVTRLTEFLDDSNIATEDDVITCKDLLRTRFKPIQHDTKNDWMADLRVFKQEKNESLVAYFNRASIFLKNLDLIDGKSENTTAESHLLSAVCMAYYSGLYDISLKRRIQQVKGWSKCISLSKMHALVIDKKNDMEQEQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R9</accession>
    <name>A0A0B1P7R9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001864">
        <property type="protein sequence ID" value="KHJ32709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R9"/>
    <dbReference type="HOGENOM" id="CLU_2172928_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="110" mass="12055" checksum="3B7D6B93F48B5AC2" modified="2015-03-04" version="1">MYPTEKRIPPLMFNSRYPGNETMAPLANNPSLPPEPPDAGNHVSKMKTLSTLRKAEAIEKALHESHCSTGEIIGTEDDMMNEDMSNASDSVFGGESQELPYLSVQITGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P876</accession>
    <name>A0A0B1P876_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 60s ribosomal protein l4-a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001788">
        <property type="protein sequence ID" value="KHJ32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P876"/>
    <dbReference type="STRING" id="52586.A0A0B1P876"/>
    <dbReference type="HOGENOM" id="CLU_353811_0_0_1"/>
    <dbReference type="OMA" id="GDYWLPT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="632"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="794" mass="90008" checksum="3981C03241387A24" modified="2015-03-04" version="1">MELPSNDIPQVASSSIAIESNQDHNVFAVSRGTIQPENKASLAISCGTISTIKDENKIDSLTSALPLSQIQSDMEESILKIDSTPVSCREYDVLLPLTTLVRDMYTEFLRTNHDKIDSVETSASLSSSQFANIDKTLDNLRKFCDYPSLEFIDEFAKQEYNQFYGAKFAENINTKIIFIIEFLGQIRPHGKRIVIIIRQELVDVFESIFKKQDIAFSRANGPKTVIENFETSRMRVTLVLAPDEISNVKHADVVIAFDSSYLQNYNSKRFGKCANFFKSSTIILHLIISHSVEHLEKILHPKTGLLNDKIRFVKLARTVASRVGKLPRGYPGPPDSAKLVAKYLLQDDLDASWPLPSLPDLKISLEELGIELNTSLSGLTEESSESPRCHVSRDSTPVKHQMLSNSTEIFDSPKRRKINSSVSNLSPKFDIEQTFKDFKDTELAEFYERVEVIDNSSGHGPILYEVNMHSRDYISSLQQKVKSLEVQLQSKEEIELELRQVNQELEMRFLDVENSIKVIQPRFQEALNDRSLFEHQREFALQKEKSTRCILEKKEAELSKIQEENTKILKELKDAHETLLNSKIPEIGELERMRCELSAMKVDFELQRKQKLAMDSDYDYLKSNYQTASISAISLAKQIQSQEKEIETLKIKASDNAVRILQFHQDNTLNRLQLVIRGLRAEKSELERQLEKLNEQQYSANYSGRPNTRGNSVPRSPRLGACLSPRPISRVIGGHNVSSITNGTRSRGSSPLLGLDNSSGLRASTTPHVEAPSGNSQQRRVEKPSMKRFGTHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H1</accession>
    <name>A0A0B1P8H1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative rnase3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001702">
        <property type="protein sequence ID" value="KHJ32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P8H1"/>
    <dbReference type="HOGENOM" id="CLU_000907_4_6_1"/>
    <dbReference type="OMA" id="HFCAVIP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="464"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="12">
        <location>
            <begin position="661"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1497" mass="171415" checksum="2BD0F7DAA4426568" modified="2015-03-04" version="1">MRIFQQRPHFNPRRRKITYFVAPSRHKDNLAVPTAKFTKSVIFRRCLSKQENESIIKSLDLEPNINKFNKSSLMDPTLLDSYKKTGFHSKDSTNVINKPSDGDETTSLVKPRSYQIEMFEECQKKNIIIAMDTGSGKTHIAVMKIKFELDRMPRNKIIWFLTPTVSLCFQQYNYIQSQIRSSEIKILSSSDNVDRWTEQTVWDSVLKNVEIVVSPYQILLDALTHGFVKFDSLALLVLDEAHNCIKKSPGARIMNSFYHPQKSQGLYVPQILGLTASPVMGSNPDSLIKIENTLDCLSRTPTKTRIDLRKRVKLPALIPVKYDENCNEYSSNSFLELKRAIEGLNLEDDPYYVSLVDRNDSKSQRKFEKLILTQKSWCGDHLRSILNISRKIYFELGPWAVDYYISKVISQASKMAKESQELNGIWEETLENIEKHYIAKVLCGVQVANPIANTFNGVPRVSDKVSKLIEILLEQEKGFSGIVFVQERAVVSCLASLLENHPQCRGILQVGKFVGTSVFSRRFTSNFDLIDTDSQNNALHDFRDGKTNLLIGTSVLEEGIDIPTCNLVLCFQKPANLKSYIQRRGRARQRESKLYLLLNSDKNQLNKFEQLELEMRALYEDETRTLQKIPLEEESSDDMKIYNQKQLQIEKTGAILDLDNAVSHLYHFCATIPCDKYIDTRPEFITHKENGLYYVKIVLPISVHEKIRTAKSSHAWKSEKNAIRDAAFEAYVTLYNAGLISDNLLPLMRHSPWDNSVIEKRPSMIKVQELINPWLDIAKIWSRNPKFIYRSTVKFDGLEFYIYLPVKLPAIRDLKVYWDKDTELIITIDSLSIEVGTNPEMLSWLNDESSALINSAFPLERGQSDEMVIRFSANQEKSLKSQIGCQKVPENIGNLRNIGIIRDHQNTGYLFKEILPRKPDAKDVQKANSEFMSAPIDVPYLSLSRISRRRDYMHPVINDTQKVSSALYSTVLPITKCRMDILPFNFVQFALMIPSIVRNLELHLIANNICENLICGTHISNMNLLVSAICSGSACEISNYQRLEFLGDNILKLCASVQIMAENPLWHEGQLSNRKDHLVANSRLARAAIDLGIDKFIVTKSFTGLKWHPTYINGILNTKDEEQRELSSKVLADVVESLLGVTMLDGGFPKVITCLNKFLPELNWKSLDENHHSIIEQAIQLDLPYQPKISKNLEMIEDILDYKFNKKSLMIEALTHASDQSGSRSFERLEFIGDAILDYVIVQEIYSYDLSHIRMHELRTAFVNADLLAFLCFELHANRKVFDIRLASEDSKNTDSIRCEESLHQVHLYCFMRHNSYAISQVQKYTNERFKDLRDEILNALENGGEYPWKALCGLKAEKFYSDMIESLLAAVWVDSGSLNAVVNVVEHIGILKFLRRAILENVNMEHPKITLGKLADNETVSYKFHLNSDMEKKPDMVCTVFVGNLQVACVCGNLSKLELQTRGAVEAIKNYKGILEERKRSTLEHDKHLEIEETDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H5</accession>
    <name>A0A0B1P8H5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative trna splicing endonuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001306">
        <property type="protein sequence ID" value="KHJ33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8H5"/>
    <dbReference type="HOGENOM" id="CLU_015560_0_0_1"/>
    <dbReference type="OMA" id="KVWVAQQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="564" mass="63764" checksum="8F802B46FDE0A1D6" modified="2015-03-04" version="1">MFISQSITSVQSDTPKSLVFRQSAPFETTKSNSTDSQSNCSPEDDEEENLNDDVLLPISQKRKRSEKDDNEDDEDEADIEDDEEVEDAEDDTSLSTLPSQESPLAKRPRSLKPTRGVIVGVWRDSCVDSDENKHVVFGFIDIHDRLRTRLYPMNRQGEELIGNFPTAAGGYWVTSEKIIFDEHLRDLKISELKEYIRIRQDSPDSQFKSEQDSKKADHTAVTAAQATVMNQDISPGVKQIQFRSTSASTRSSGGRQLLPREPMIPSPKALNVIESRTSKSSSLGDGKFQGVPLGFWTDSDGTCDEDKHAVFGVLIGTDSFRVKVARQTRDGRHRDGNYPVGPGALWIHYDKVFLEPHLRSCSRPEVKEYCRIRLEELQFKESEEERQANELRAIMKAKEIVAGGIPRRTIDLEITNVKSELENRKSTRVEQRRKSQQKVEIDTSSDEAVVKPSKSQLDIHDKKLVKSRRDTLNAEISVVEAAEKELKSNIKKLNKVWVAQQAITIPGVNSVINAQSEIRYHNGIKYERKKNGPFQGKLVSPAQILTIDGEDFVEYRILTKPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Q9</accession>
    <name>A0A0B1P8Q9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative duf1716 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000779">
        <property type="protein sequence ID" value="KHJ34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Q9"/>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="OMA" id="TDWREQE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="66127" checksum="667E30C1729D677A" modified="2015-03-04" version="1">MSSMKAIDDLFKSGSSSLKRKFTDPKYSSHSSKSAKIQEIHVENGKSNASLEDNVKSDADSDELLNKKYEVDIPDDEEGRFFGGGVTEKQNEIIDYVDQQMSTDVLPERIDSSWLRKQVLKFERKIQKNAEQRVRFEQEPLRYLESEAELHAEIKALSILSEHPELYQEIVKSGCIGSLISLLTHENTDIVSVTLEIVSELTDENVEAEQSQWNEIVNTMIEADLLSLLGSNFSRLNESNESDRSGVYYSLNVLENLASMANIAEKIGKDKCIFDWLVGRICKNESPVSQNKQYAAEVLAILLQFSTSNVRIFCEMDGVNLFLEIIANYRKQDPAKGTEEEEFVENLFDILTRVVNTPEGKAKFVEAEGVELCLIMIKNGKMSKPRALRLLDHSLGSLSGLDACERLVEAGGLKVIFSMFMKKQDGSNTEHLLGIFSSLLRLLAANSAYRIRTLAKFVEKDFEKIVKLINLRREYASRLKLAEEKIKKSQDMLEDEAKELATDEWLSKRLEAGLFCLQIIDVILAWLVAEDDGACEKIRYLLSEKGESLTLISKTLNEQITANVGDTEEEKMTKDMLSTLVKFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P933</accession>
    <name>A0A0B1P933_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative altered inheritance of mitochondria protein mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001222">
        <property type="protein sequence ID" value="KHJ33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P933"/>
    <dbReference type="STRING" id="52586.A0A0B1P933"/>
    <dbReference type="HOGENOM" id="CLU_038840_1_1_1"/>
    <dbReference type="OMA" id="FMHLRDG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="387" mass="43855" checksum="EEA958CFEF32E97B" modified="2015-03-04" version="1">MRSIISRARQCLLQRRCFTIHTSTLSKLKAESPVEYSHKDSTPNKTRLDPITLHRLQSAQRAYYKRRMVYSTIGVLCGMVGLYLTAIQAPLSPETPTILKSSTPNRLDSRKPDDDPLLILGRERKVVTRKLDDISEERENSVNTGNSVVPEFPRVLKLNNVSSDDSEFTKYYLLGLGTRTVSFLKIQVYVVGVYVAAEDIVKLQNNLIKRVNPQATTLILNEKDELRSMLNNPEQNEQIWDTILKEGGCRMLIRIVPTRNTDFGHLRDAWVRSMKSRAQKAEWNDEKFGENVALFKRIFARGNIPKGTELILSRGSLGNLEVWYHGQSTSRLDKLGEVRDERVSRAVWLGYLAGKGVACEGAREEIVASLLKFVERPFGAGVSQIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P942</accession>
    <name>A0A0B1P942_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g0013</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001585">
        <property type="protein sequence ID" value="KHJ33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P942"/>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Region D6 of dynein motor"/>
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        <property type="entry name" value="DYNC2H1-like_lid"/>
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        <property type="entry name" value="Dynein_2_N"/>
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        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_heavy_tail"/>
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        <property type="entry name" value="Dynein_linker_3"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
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        <property type="entry name" value="MT"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1946"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2237"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2602"/>
            <end position="2752"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2944"/>
            <end position="3110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="3192"/>
            <end position="3268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="4363" mass="498352" checksum="A7E9D82892EE5879" modified="2015-03-04" version="1">[encoded data, 4363 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P946</accession>
    <name>A0A0B1P946_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative water channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000477">
        <property type="protein sequence ID" value="KHJ35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P946"/>
    <dbReference type="STRING" id="52586.A0A0B1P946"/>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="OMA" id="VPTAMFY"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="31437" checksum="FEEC9CDD6952E99F" modified="2015-03-04" version="1">MSGNETTPMLGNQTPLKLRKYEGRLNDEKFRHHVIAAIGEFLGTTLFLFFGFLSAQIINSKSNELSTDGPSLDQLSFVAAGFGVGAAVNVWLFYRVSGGHLNPAITIGLTLIGAVPVVRAGILVVVQLLSGILAASLAHAVTPGPLNVQTTLGQNTSLLQGLVIEIILTATLVLTVFLLAVEKHRTTPFAPLGIGLVLFLNVLLAAQYSGASFNPARSFGPSIVQLEFVDYHWIYWIGPVLGAVGASVVYKILKFLHYETAVSGQDHDGLNVYRLIDDSDGREVDREIQLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P958</accession>
    <name>A0A0B1P958_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative d-arabinitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000471">
        <property type="protein sequence ID" value="KHJ35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P958"/>
    <dbReference type="STRING" id="52586.A0A0B1P958"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="GYRICIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="38858" checksum="9748228912B41648" modified="2015-03-04" version="1">MIRSPLLRLVAKTPSTRFPISVANVLDISNYNLRSLHTNAHNFQRNDDEKNKSFEGSFARTDPSVEVKYPDEDQIPSSTPIQGRGGLHFKRTLASFSLEGKVGMVTGGARGLGLVMAQAMVISGADLAIIDLNKEEAEKQCGEIIASFVRENPNAQRIPKVTAHHADVSSQESVDAAVTEVIEKHGKIDNLVTSAGFTENYEAIKYPIDRVRKLWQVNVDGTYLFAIATAKHLMKRKAPGSLIFIGSMSGAIVNVPQPQAPYNASKAAIRHLAASLAVEWAHAGIRVNCISPGYMLTALTKKILDEKPDLKKKWTSLIPVGKMGDPEDLMGAVVFLASDASSYITGSDIRIDGGYTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9H3</accession>
    <name>A0A0B1P9H3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bgh specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9H3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9H3"/>
    <dbReference type="HOGENOM" id="CLU_452128_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="604" mass="67103" checksum="331A5BB0CC95CE93" modified="2015-03-04" version="1">MKKNLKNNNNDQPKTESNDTAEQNALADIHAAMMEELGIGRKDTLPLQDTYQIIPKHSKIQFKLNPENVAPGVNTWRNAVFDDVDPAEGEIDSIADGQLARIRRRLMNNQYPESLLGKNKNSSLDKGFVSHPKNSKDLVINRGQEGSRDQDPLPKTPNDIGSSPLPPSKISKANRNKIDKSRLNTSIARLRSAVPPTGSSTPTLPGASKASTASSKQKKSNASSIGSSSDHQKISKDKVKGPSSKSKSKGRSQRSKPQITRPLLQRSAWGALDEDAFLAYAIKPTPPTSPQAQNKNGIQSPIYISSSSSSTSSPSSQPEFIGQKSSFLTQDKFQEQKSEKSAQNKQEFKDNSLATRNQTNHNVSQETSQEKLTPLIRDMNIKSPEYLHTILPQTSGQNNLEGFPILSPSNHTNLMETKSQNTAEIFTGFSLSQNVNMEGRAMIQVDAGLGLPGYARLRGDSRNLFLELQQSDRIIACESLESEIVLITDSMNPKFNLIIEILKDYSPPNPIWRISFEFSHIKNEFLKVILNYKAQKRENNLLQNSVIDQRKSIIDILDHKTMPFFKNLIHIGVPKRQENIRPNDAKIRTETLNDLSEIGGISHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I8</accession>
    <name>A0A0B1P9I8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000431">
        <property type="protein sequence ID" value="KHJ35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9I8"/>
    <dbReference type="HOGENOM" id="CLU_089396_0_0_1"/>
    <dbReference type="OMA" id="QWFDARE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="32115" checksum="96113D4144C7297E" modified="2015-03-04" version="1">MSSNGYYSNPTTDLASILRTLASLTPQIQNQNQNQNQNQHQNQNQNRGQSQSQQQFKTFAPSVEESLNQSYLKPNENVTSNSQYKPAPALEAFLPVASNNSSTIQKKPTLSKNIVDPTSIIEWPAGLRCITKTVAKNENILDEIRRLIKNQHEHEEQWWNGRNTLIDKLKAREEGQKKLDEVLRAVGGVVSMLQPDNNIKSVERELQTFDLKVYKAQIQMVREMNAKLRSLGVPFFGTRSELVRPAIKKTEIVKDEAGLIDEADLVKLQRRMLEMLEDLCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N0</accession>
    <name>A0A0B1P9N0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001078">
        <property type="protein sequence ID" value="KHJ34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9N0"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_8_1"/>
    <dbReference type="OMA" id="WINAKYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="285" mass="32372" checksum="8E08B24FA5669F30" modified="2015-03-04" version="1">MLALNNRTSASLGMSPFFAEHGYNIDPIEQVEPLSKPSEPAKRAQAFVNRIREAQELAQAAMASAQARMEESANKKRREAELFKVGDRVWLNLKHVQTPQLSKKLSWINAKYQITKVIDSHTVQLNTPSGIWPRFHVDLIKIAATDPFPSQIIDDEQPQPITPQISNTINVSADTGEEQYVEKILRAENKKIGRGYRQSLLVKWKGFAEPTWEPRQNLEDTEALDVFESLYGTKDNVGECEGTIIGRRKVTKRSLLKNAPKKNKNKNKTNTGISNFKRNSFWEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9R5</accession>
    <name>A0A0B1P9R5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative snf2 family helicase snf2 family helicase atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000403">
        <property type="protein sequence ID" value="KHJ35427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P9R5"/>
    <dbReference type="HOGENOM" id="CLU_001161_1_0_1"/>
    <dbReference type="OMA" id="RIKKHQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1228"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1619"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="751"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="878"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2033"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2033"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2056"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2099"/>
            <end position="2108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2108" mass="239897" checksum="1B8A22DACEDF78D1" modified="2015-03-04" version="1">MALELNMGDPWNWNVDRVVQELCTTNRTWQPQSPAMPLISDPESLAAILRDQEVTGSVLLKEINMSVLKNEFGIRALGRRSFIMSAIDQFRSRSLLYSSCISEPSPNLLNSELGIGLQEVLCQIQQKSFAKPSNFYSQLVQPKLANDQTCKVSLPVDNHPPKLVGTSKQGTETNLRPNLGSDNVEQEQIKTTPPPMAHIKDTKLDENSQEKNSIIHNASIILSTTVPSSSSCELPVEEVSERCGMKRKRIAPTLVSSISNPVISLQDTSTQISPSKIENNVESVTSINQQASTSEKIIEPGIIFKDSNGRKRIIPFLQVDPNLSRNETEKMLHTRDESQSNHSLLPGQSSNTPKNPRSKSLYSDIFLGKKKMNIDSLFYDGTPVGGEIKISEHPTNFYSGKKIITKGRRLYVHKCLQYFLRSQQHEIISEGKKCFIKIPYPEHLVLKYKDQSFTLYRLTKDGKVVARREANIEASSHNIQSLGEERLVLFNTSNRNLLEQVGSGTEWDYNSLEKYKFLEGGDEILPLYGESDEDNEFDEATWKEIEDEYGEHERPKQNLRKPPLSEMEVVKAIEAGIADIVNLWKTKNFAKRERKAWRIWRQSRRLKNKDEQIAAAKIDLNHTQQYLDKIKERILSETWTSKLQVRKQLGSMEASIISQEELNWKITILKKRTQPVKPPPASPKPKIKKVVVKNNTKNDIEDESISSSEPQSSGDDDDDFIDDDFIDDEDEKIPDEMHLHELNFADSENEDVILSESSSSDESSFSSAVRSQNKRKNPEVSQSLVNRNSSQSKNHPRTLGNLEVSSDIDYRSSINSAKNNTAKLKCKESETPNFRNSINCDFIDLTLGSISDDNESMKACDFSTPSQSNKANFIDMTISSEDESAPKCKRQSIMRPESSEIYEKSPSSSNDSPSPIRTKKNFSHNQRRSSEQSFDVIPTYDKMPPLRNPEAIAKYSYDVWQKLNDRERLLTKYFFQLNLTLRIEILREFSNSSSEQLWIEIRRIIRAKQFKDINISQSEDTRTKILVRIISVFEMYVDCRYYTFKSKLEEKQLKKFRMTRLKDFNLFYNICLRISHFIKLYTRANQVAKFRSSKSTISDNGYDQSYLYSQPSDRQFRLKANSTGESESSSYETRRSKRKKPVCENKEARDMREQDLRRLAQQNERRKKLHATLVEANDDQAIVRSQLIINDAATEDQKFIYVNDHIAKRIKKHQVEGVRFLWNQIVSITDEKSMQGCLLAHTMGLGKTMQTITLLVAIAEASRSNDPSVSSQIPESLRVSRTLILCPPSLVNNWMDELLLWVPDSILGELRKVDSSIKSLPQRLQIIIDWNEEGGVLVIGYEIFRDLVNYKSKNISDAEHELVSKVLLEGPNIIIADEAHRMKNRKAAITIATSKFRSKSRIALTGSPLANNVEEYHTMIEWVAPNYLGPIVEFRAKYVEPIQAGNYQNSTAYERRKSLKMLGVLSADLAPKVHRADMSVMKNDLPPKKEFVITVPLTDVQKEAYTIFVRSMMAGNNYTTTKLGEVTSTTVWHWLAVLSLLCNHPECFRRKLIKRKEEARIGSSNSVDLDESDNEESAVDLNTPVWKVGVSQELIDAECEMFAAKKSLSSIQMSNKVLLLCQILDACKSIGDKALVFSQSIPTLDFLEDVFKRKNRNYARLDGSTAMSKRQVQTKDFNNGDTDIYLISTTAGGLGLNLQSANRVIIFDFKFNPIMEEQAIGRAYRIGQKKPTFIYRFIAGGTFEDSVHNRTVFKTQLASRVVDKKNPIAWANKKTSEFLFEPKEVPQKDLSEFEGMDPCVLDRLLQNQKRKDQRGIRRTICNIVQTDTFAVDDDDKLTPDEEKEVQSELEKTRLFRANPHAFLLQQAAEQQYLRQQFMQQSTISSIGKFPPNNFNADPNSMVKRNDQNASPEFLAATGFSSMGIQGSFITTSISNESFPNSMTNSDTNSQIKTGIFRPGITKACSPVAGANTKVTTLESENLNVTSITPNEPVNSQKILVLDKPENVTLLRSNDSRIIQLDDEDKEIQTENFHKMLPKSDDKQQKPENLESNQSKKSPEEWDISKRYRESRGSNLPDYGPIVGPSLSNPIPGNRFPKASFNNLNNKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9S2</accession>
    <name>A0A0B1P9S2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001463">
        <property type="protein sequence ID" value="KHJ33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9S2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9S2"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="22444" checksum="632F87C2F254B546" modified="2015-03-04" version="1">MISPSLIEKIKPVLSGFALIPCSTEACDTILNAGNGLFLTGAKLEPATNWVSVLIPTVPSKIRKQHGEVEINSSLLSDEIERVCSVRPAHVKLYGRNKPEAPHRTWMAFFVKAPHSSFRVFDESGIARSFKKQQSIEFCKRCNGHYPAKDYSRAPSCSNYGSTNHAADSFMAATKFRNCGGPHQSDSRRFLARPTCSRAPTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA74</accession>
    <name>A0A0B1PA74_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle inhibitor nif1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001220">
        <property type="protein sequence ID" value="KHJ33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA74"/>
    <dbReference type="STRING" id="52586.A0A0B1PA74"/>
    <dbReference type="HOGENOM" id="CLU_033724_0_0_1"/>
    <dbReference type="OMA" id="WEARATM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34618" checksum="AAC2195B06DC50BE" modified="2015-03-04" version="1">MENSGIIAAKKERSACWSKPKVSAFRRLSKHLHRRKKRASKKVPTDLPDIEIITEQVERSVEKKINEIRSQWEMRAMLLAKKNEESQKNFSIPEGESDVNILPGNHTNEGDKKPISCMTTKNNNGDNIQEAIRLHEAGELQISTEMFGRLAESPGENNNLSQVLYGLSLRHGWGCTPDPVKALKYLSAAATSAASIEDSALKAGKKMGGLARGELVIAIYELANCFRNGWGLPVDEVAAKQYYETAANLGDTDAMNEVAQCYVSGFGCKKNKFLAARYYRMAEREGSKVLGNSWIWKEKYNLPTQVTFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA78</accession>
    <name>A0A0B1PA78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000327">
        <property type="protein sequence ID" value="KHJ35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA78"/>
    <dbReference type="STRING" id="52586.A0A0B1PA78"/>
    <dbReference type="HOGENOM" id="CLU_054797_0_0_1"/>
    <dbReference type="OMA" id="TCLHWGH"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF53">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="52"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="36264" checksum="43F34A97F9F25C2F" modified="2015-03-04" version="1">MFFFNTLRKFIRKGKSKYHNFINTLSNQNDNFPPQATPAVNYSNKPTASSQATGGGLPPPHVFGSTYWYPTFHPSTPLGTFFEQKTGAHGWGNNEVQNYTQSPANSFFTPDNKLVVRAISKPDSTEEKYTSARLVSVQKLERARGCVTARLTLPFAPGIWPAFWMLPAEPFDWPKDGEIDIAEVWNAKAVNHSCIHWGHYNAQDSQKHRVVETNINTANNLHEFAFVWEQPTSQGAQSGRSMWYIDDVPVMRAFIPEGIRPLQDFRIILNVAMGGNVCEGVLPAAGVYDLVVHDLRMTDEPRGGWNRFNSDWDRTQEGHTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA93</accession>
    <name>A0A0B1PA93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001190">
        <property type="protein sequence ID" value="KHJ33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA93"/>
    <dbReference type="STRING" id="52586.A0A0B1PA93"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="OMA" id="DNQGPIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="23162" checksum="FB5F623474569B90" modified="2015-03-04" version="1">MSNPATRHGQGIKELMRYLRSIVKQKIRYGPGGEDHNDHFVIYTDADWASDVTDRKSLSGGVGMFYGGPFCWMSRKQRCVARSSCESEYISQSTYAMQGQWAAQIFRDFSMPEYIGSNSKTVDMRGDIQGAIALVKNPQLHERSKHIDVCYHHIRDLSEKGKLKIEYIPTADIPADGLTKPLTRIAFERFKNQLGITHESVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAE1</accession>
    <name>A0A0B1PAE1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000481">
        <property type="protein sequence ID" value="KHJ35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAE1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAE1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="KSWANIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="58785" checksum="47A9B365098DBAA0" modified="2015-03-04" version="1">MADIAKSRAKARLKNKGLTPDLIDINAFESAINDNDSPGIEMIDEEINRLIAKARLINPTSEESIVIDLSTSQENSRIPATNIPQEIPVTTERKPLCPPELQKVVKAEERRAAQMSANLEICIVAINGFEDALAHLTTSTRNDFVVSFKVYLKNAIVQFMRSGTSAIPPTLPCRPTCPPPAVLALKNTARSTPTTKACINHPAKNQINKSWANIAQKGHQKSPNIINISQNHSTVKISAKIINKKSAPLGGVMRLFLRISKDHDWQLLVLCGVREVLCIHLKCSPSDITNITRTPTGFTLTSKDEETRQKLLNNYEELALQISKLEPASDLITYRIATVPVALRTPNGTVIVEETNLAAEITRVTNVIPRMVRQHGKTRAGAPYRSWLTNFARDQAPRPGFRLYDESGIAVIFKPRQPIQLRKRCFGFHITRSCSRTPACENCSSTMHIVTDCKAPTKCRIDQIMIRQISQREYHAEARAKAAIIRAEAAAINEETPPIYPKNNLDVILTNEVDMSEASIDVGTSSEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC26</accession>
    <name>A0A0B1PC26_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative meiosis specific protein hop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000629">
        <property type="protein sequence ID" value="KHJ34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC26"/>
    <dbReference type="STRING" id="52586.A0A0B1PC26"/>
    <dbReference type="HOGENOM" id="CLU_398061_0_0_1"/>
    <dbReference type="OMA" id="VISCECH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="692" mass="78887" checksum="FA26BFF3B33F3CAE" modified="2015-03-04" version="1">MPLRSRIQQRGPIPSPTSQIILTHKHSFELMKTVITATISHVLWARRVFPDITYNLRSYDPADPEVSYDAFVKGIKGTTTSFDASENLMIWKILPRSQDPAVDKVLDCLEIGAADALERGYLEKLQVSLHVADENLITDSNLIESYTMIFEYDENQNLRISSELNLNSIVIRSAKQDLYGLVNDVGFLIHHNNRHRSNGSELPDEFRMLLSLKYNMNAPIDYQPPMFRPGDRNTIRILGSGLPNPNLKMNTGFHSVSIGINILEDIELTPVNQLSIKVPDINAMSEVVSPEIQPITSVYSQMEEVITQPDAVKQLQKIGISRNPNSDTQDTIKLDYIDPKIIETIKTAHENSNKHNFPPYTQPIINEIQLALERNKIISNMTGQLECECKVLIDDESLFNCIICSKLKHVRCYGFLDCILTTYVVCYTCLLGKTEKDRIEKIMKPLAIKRRALHYLRDKGTLSSCSELAPQLNIPKYRITRLLGEFKSYGLLKGSRKDKKRAPMATYIGDDEKLRLLYFRPQQEIDHYFSVSILPTLTTQDSSRRSPTPINRTLNSQILNQNNPSKNQRHILPDRSVLLKDSDHQKNQSTLNVDCAHQPSAKQIVKLVKNTPQVCSVIGSSTQGTPSPRPRSQSSIVFQSRDFVDQKRDEYIQRKRSYLTTKSNDEVDAITEAEETKRLRTSETSPWIIRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB1</accession>
    <name>A0A0B1PCB1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 30 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCB1"/>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OMA" id="VVAPKHQ"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="19917" checksum="43C86C9E1C06CC1F" modified="2015-03-04" version="1">MALFPRSFITNDQSAFPPIFRLLDEFDQYSRSVDRPNQHSSLKTFTPKFDIKELRDSYQLHGELPGIDQKDVEIEFTDASTLTIKGRSERSYTNESADEKSGGKAEGNADGKDKKDKKETENTFWVMERSVGEFSRSFGFPVPVDQDAVKASMKNGILSVIVPKAKKQESKKITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD8</accession>
    <name>A0A0B1PCD8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gaf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000068">
        <property type="protein sequence ID" value="KHJ36332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD8"/>
    <dbReference type="HOGENOM" id="CLU_360638_0_0_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="277"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="776" mass="86660" checksum="660610B1A6C3D6C8" modified="2015-03-04" version="1">MEAKALSNASSNYRYVKSHQENIKTPLRLKKSSSNGLFRLFSKGLPNNDKNSSGLSEEDSVAAGLRDIGLEVGPCNYIRPNGQKLEPRRESEYRRENLTSGLLPSPRRMTQKKRLPSNRDSKPDAVNGEASQPKISQAKETFRNRALNSQLVIKDPESSFHLDVKNFPVPSPLWSPLLSPVTPVHATGLPAFASIKPQFVVGKIAMDGESSPMWTAWLKSYSKGEFNIQNPPEPPPLGSTFTHLPAVYPDNEEMRSTASKIHEHLWKELAYDRAKIYLREAKKKFGARFGAISFFDDEYEVCKAEKGYSVKHIQRSNSIAAHALYSTEVLTILDTKTDWRFRGNPMVVGKPHIRFFAATPLVNPDGDILGVLSIFSQEKCEIFTYDQRRQLAEHGAALTSELMAQMEHLKLPQITKSVTPVGSQISPSSVTSFVSKFSQSQRDSASEADLSRKNVNVIDRHPGRDNPLPPPPVPPPPVPKNHIFGQYPQSVGQNSTRPSTSRSRILIETTPPPSAKSNQRPSVDGPRDLPLRSRVNSSVSRLETRPRGDSLTLSYCTTSTSRPTSRPASRRTSKTCNESDLNHQFIRYENAENFEDSTFSSHDPTFPTTIDSDSKDETMESFFEDLSSYSFDTFPKSNLKSSSKLASLKPLPPISPSNIVDTQHQSCHPNLNMTVEDFLSLSDGDLTEDPTVVSSIEPNPNNCTNFSNSTINDINITEGNYPDNNYKSNDYDNHYKLTTNIKPSFASCHKSKSRISDNLLSWKFPRSDSNIPKIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH4</accession>
    <name>A0A0B1PCH4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g1423</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000042">
        <property type="protein sequence ID" value="KHJ36377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PCH4"/>
    <dbReference type="HOGENOM" id="CLU_000443_0_0_1"/>
    <dbReference type="OMA" id="TLFIAWN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="435"/>
            <end position="464"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="543"/>
            <end position="562"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="599"/>
            <end position="622"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1243"/>
            <end position="1265"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1285"/>
            <end position="1307"/>
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        <location>
            <begin position="1319"/>
            <end position="1339"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1376"/>
            <end position="1401"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1500"/>
            <end position="1522"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1581"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1613"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1645"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1669"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1699"/>
            <end position="1723"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1793"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="1837"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ36377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2151" mass="244202" checksum="8F4EDBC9B367AA61" modified="2015-03-04" version="1">MPTKRTEDTSKPSLTPLQTIPLRDLAPSAQSSDESTNGRRSELSREKSLLRVSSRIKTLSCDSSRSKYEKIEETSPGIHSSPNIEKISPLKNVVYFEEEFGNRLCGINVITEPQPGTGFAGLIVPKNDESSSARTLTPPVENDDLEFNLVNNTHVIDSASIFGAHELESIPLTKSSFGNLEKNVENSLMENQPHERPRVRFQGVRYKNSRKNRSQIRLVDGSTDIEADTEAGQWPDLPPSSNGHRRSLLASRAPSNATDALTRAGSIMRAMSQRVVNISGEAEMIEATAQLEASRQESISSVESKESISSNSHELKPAVQSNHKGKSIESEALPTTRLPTAPIEKAIRFFGGIQSELDDLNDSNKKLPNPLRGKALGYFSQESYVRNSLCNLLVYPLTEPFILILIIAQLILLAIESSQNVYEHPRITRWGASPIDYALLIIFIIFTIELAARIIVSGFIFNATEYSTQANRKKFSIKFLSKFRQLIRSDKKPSINKNQPSPIIGFEHRSLISIQSQLVKTVEQAQRLQLARRAFLRHSFNRLDFVAVCAYWLTFILCITGFEDKYHFYLFRMLSCLRILRLLALTNGTSIILRSLKKAAPLLVNVSFLIGFFWLLFAIIGVQSFKSSLDRQCVWIDSNDPTNSTGSAYINTFQFCGGQLNITNGAHDPWVVGPLGNLSPGTESPKGFLCPRGSYCLQLPNDKLPFNGTVSFDNIFQSLELVFVVMTANTFSDIMYNTMNSDYLASAIFFAGAIIIMMLWLLNLLIAVITSSFQIIREEGKTSAFSSQTKAVQSKGEDLKTDNYTKKYANALKAWFDTTDLLWVALIAYGILCQTFRSSNMPKTLAQFIETSETIVTILLLFEIMIRFIVDWRKFSKSKRNVVDLSLAIITTIMLIPSIRNSEKLYAWLTIFQITRVYRLIMALPVTKSLIMLVLGNSSGIGNLMLFVFLITFLVSIFAVQLFRGELPPEDAYGETIQVTFFTNWNAFLGMYQILSSENWTDSLYNLTSFNSIYNTSWIAGIFLIGWFILGNFILINMFIAVIQENFDVSEDEKRMHQVKAFLNRKELGSSSSHLSLSAIIRLGRPRNKKEPLDYGPATMEMLLKDAVVKDFLDDEIKESQILAYQKTPPMVSLTGSHKSKSSFWQKMKNHFQEKEPNPFFSRTHFSGTSAVENVDARSMAKEVVSATTQRKRAQRDYLARHPNFNISLFIFKPENPVRRLCQKIVGPGRGSERFNGVEPNRAVWYVFTTIIYTAIIAMVLIACITTPLYQREYLKTHKSNAQNWILISDTGFTVLFTLEALIKAIADGFYWTPNAYFRSSWGLIDATVLITLWINVITSFTKNSMISRAVGAFKALRALRLLNVSESTRDTFHSLVIVAGWKILSAAFVSLSLLVPFAIYGLNLFNGKMLSCNDTDPSKINLLSDCFGEYYSAPFSSDWPILAPRVVSNPFFDFDNFGSSLFTLFQIVSQEGWVDVMWAAQSIIGRGIQPQPYSSQENAIFFVIFNLLATVFVLTLFISVFMRSYTEQTGVAFLTAEQRSWLELRKLLRQVSPSKRQSTTGANNFKSWCYTKAVQKRGKWYKIVSTMLALHLTFLLVEYYPEPTYWDQTRNYIFFAFTLFFLANVIIRIIGLGWARFRRSVWEMYSLLIVSGTLGTTILYLLQLKSQAVIQLHKLFLVMIVLLLIPRNDALDQLFKTAAASVANIGNLVATWFVLFLVYAIALNQTFGLTRFGPYEDNNINFRTVPKALILLFRMSCGEGWNAVMEDFATILPPLCVSVPNFFDSDCGSSQWARVLFITWNILSMYIFTSLFVSLIYESFSYVYQQSSGLNKVNREEIRRFKEAWALLDPNGTGYISKEQFPRLLRKLSGVFAMRIYPPEHSIHRILNDVRQKTTREVSRKTLGRYLDFDLNELNRRISMIDTEAVRRARNQFSMFFEEIMVSADIDRGISFTTVLMVLAHYKVIRDNKSLKLEEFLRRRARLQRVEEEVRRRIVLGFFDTMYWSRKFRQHLETKRFGQVLNPPKQGPSIYVTNEEIFKQKVINTQSSIHKTQDQTNKLSMLNDYNLDGGACRRRSVSRSNMAISPVILSQHSPIIAVTSGFALENCEIGGSNCSSRRGSSVSTENVLDIIDDSAWGESVRRSFILRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCK0</accession>
    <name>A0A0B1PCK0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative vacuolar segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000539">
        <property type="protein sequence ID" value="KHJ35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCK0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCK0"/>
    <dbReference type="HOGENOM" id="CLU_026440_1_0_1"/>
    <dbReference type="OMA" id="DDVHQNL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF29">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="280"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="577" mass="65563" checksum="72C2D7607F357A6D" modified="2015-03-04" version="1">MPSRKLGGGRILGNGNSLASIPLAHQRISQTTPAVKHKAFEEEHLDDNHQELPEVQQDEVKTWFDKQVVKAKKFQPLVVINQKLKGLDIFEPNESPIVTTPTTLSGKRPILSELSKLDPDELVIKSHWQKLGYNDLCTEPSCGKKLGSVNGNVNCRKCGRLFCENHTMYQIKLSRSAQHDPLRGLWCRVCETCFKSRDGYNDHNGAERKHTSDFVKIRTNFLNKKHLEISRLEKRLTKLTLLLSNPPDEIFANEGVLVQLSGQKNQKKILEQSIVVWEEDAAAPKCPLCHQEFGSWSFRRHHCRICGQVVCGDPRTGCSSEISLEVTAKKNSGDLTVDIRMCRSCQSIIFSKKDFQDDISHKPPDQLAYENLVELERGIRLLLPKFQLLLKALQNLQIPSSQVQLTEAAKVRKRLIDLFGKYDQAAKRIRDLPSKSFTQLKLQKAVYQQSANFLNIYMLPLKSLPKLLKATSSYAPNSLPSFTSLETVKRDTHDLRSQASSSSAASSLEVEERELMEQLIALEEQRFMLNEMLSVARKAQRADEQIILSENMVEIGIECDRLRNMLDNLESKSMKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD79</accession>
    <name>A0A0B1PD79_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g0819</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000630">
        <property type="protein sequence ID" value="KHJ34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD79"/>
    <dbReference type="STRING" id="52586.A0A0B1PD79"/>
    <dbReference type="HOGENOM" id="CLU_031900_7_0_1"/>
    <dbReference type="OMA" id="YEWFHWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="345"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="227"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="43439" checksum="85AD9AC01C2999C2" modified="2015-03-04" version="1">MTIIEQNDAATVLDDWINRVTNLPNEIAFMYEEIEQKDRQIAECLSIISKHDSTLQNWVRKNGGHMPNPKESSISKIIIDKYDKAQALQSEKIALAQKCQLIVDKHTRNLDIHIKALQDRGEFPNDAEIPSLLRNTPIQLASRAVTTAATPSQTPVLLHTRNSNQSTQTTTHPQVLPQPSTNTPISVSVTPPSVALTGRQARETSISLGNKKQNIFSSSNILGTSSSARQVSLGPGSSKVATPATTVRAGSTGPRTQVRIGPKKFIPHGGKPIGSGRKQKKSGLSRLKRTGNKTSLSPSQDGEHSGAESGSIHDDDEVHTPKRNQDAEGDEEMIDPEEDDGADNRKYCTCRSVSYGDMVGCDNPNCEFEWFHWSCVGLKSEPLGIWICPACKAAGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDW6</accession>
    <name>A0A0B1PDW6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDW6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDW6"/>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001145">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="407"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="872"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="967" mass="109818" checksum="3860ACF3E44BF28A" modified="2015-03-04" version="1">MALSSWKTFDFFEVNQVNPVGQDLKFLLENNEITYVCSGPENIFFGCDDGVVQVLSPAFVVIQTFKAYDNGSITYMKQMQGTSFLVTIAEDITNEPVLKVWALNKPVKKTGLPTCQSSLSIQNGRKPFPITSVAIMDNLSQLAVGFGNGSVTIVRGDLIHDRGAKQRTVFESEEPITGLIIREESRSMTLYISTTSRILKLIIIGRGQGQVARTVEDTGCAVGCMTLDSTSNDIIIAREDAIYYYAVDGRGPCYAYDGPKNLVTTFKDYVVLASPPIASSKLRKSNINYRRFGGNETVEILSTSNFTLLDTGLKLIAYSESLVSQIKYCFSILGDLYTLTQDGKIFRYHEKPQQQRLENLYQRNLFVLAISLAQKSGMDSANQNIIFRKYGDFLYQKADYDGAMQQYLKAIENIEPSQIIRKFLDTQRIHNLIEFLEELHEHHKANSDHTTLLLNCYAKLKDIKKLEKFIKSPGDLKFDLDTAISMCRQSGYYDQAIYLAEKNEEHELVIDILIEDSKIFDQALQYIYQLDPYIAYTCLMKYAKILLEKCPEKTTQFFILYFTGRFCSKKKELTPGIQTYQPGYAAGAVNAVQSLKDILPLPYMNTSGPTETIVNADSIKKPPNESLMPSYSIPPIRTIFSCFVDNPNELIEFLEACLEQRSLKESDKADLYTTLFEMYLHKSHGNDDDREVWESKARKLLEIEKIPIDNTKVLLLSHLTDFRDGSILVKEKSGLQFDIFRSYTSIKDTRGAIKALEKYGSEEPQLYPAALAYFTSDPKILEEARDEIDVVLKKIDKDRLMAPLQVIQTLSTNAVATMGMVKNYLQETIERERKEIVSNRRLIESYRSETFEKRKEISELSSKPQIFNNTHCQFCGLQLSLPIVHFLCKHSFHQTCLNLDIEPDGSIEGSCPSCKKDNDTIRAIRKAQVESSDRHDLFLDALRHSEDRFGTITEFFGRGVMDVAIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEJ5</accession>
    <name>A0A0B1PEJ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative endosomal peripheral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000438">
        <property type="protein sequence ID" value="KHJ35301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PEJ5"/>
    <dbReference type="HOGENOM" id="CLU_001169_1_0_1"/>
    <dbReference type="OMA" id="AWRLCLN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="200"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1691" mass="186464" checksum="1352D11D026E50A8" modified="2015-03-04" version="1">MTAQVLVSELGNLVQESKRKHSDLRAAAEKSLAEVRSLWLTSEAQVAADLSQRFNFVTPFIIACSTKNVKLTGIAIICLQRLSMSRALPRVRLKEVLEAFREASSAGLDVQLKILQALPFLLQNYADDLKGELVATTLNICTVLQSSKNGIVSNTAAATLQQLVVTVFDNVVAEDKSGEDVPIVGEAVTEDGSIQLRPAALDAYKIFNDLCLLTESHKPLFLKSTGIPKTFGLELIESVLTNHAEIFINHPEQANILRLRVMPFIINCLSEKLNFAVTVRNARILYTLLRFHLSILSSEAEMALSLLTYMLDHDTASWKRSLCMEILRGLFSDAALVRRVFTMYDSQEGRKPILRDLVAAFVRVSAEKPSVIGLGPQSSVPWANQGSNIENDQAILEASGVPGIIGSSISTTDPGVGISTQWSTIRVPCIDQLDKTEPPLVPVSYIYSLTLACINGFSEGLARFILPLTAPERSPQRLKSSQIKVNEYESSTGMAEPKPKFKKQTSVRKNSGSINPLTLENHPLIDEIRACAGIVDKCWPAILATCSTFLYAALDAEYYRGLVRSFQKFTHVAGLLHLSTPRDAFLTTLSKAAVPSNLLASNNPTTPPLPTPPSNFERQSMFNNAKGLLSGEGSTSNKGRQSSSADSAVALLNTRNLLCLRALLNLGIALGPTLDSGWAIILGTLQHAELVVFSSSKSRSNTTSQKTHDQSTSEDPTLLANFGIELKAVETAATRLLESTIELSNSHFMEVVTSLCSLFGNDVSLAQDKHKLQSAPDLRRKSYSHARATSIITSPIIQSQEDLFVLSKLSDIASINIDRLIFFPSDISGWDPITSELINAAYSRASSTSVRLKAAEILTKIILEAASAASSLTESEFIDVQLRLLDTFKLALKPLEADARDSSVAAHVADIDVHKIFLEGLKSFLENCGNTSVSGWNVVFFIIGSVFINKDIQVNGNLKESNETITRSGKLIRSAFNSLQLICSDFLSSLPNNCFIILIDTLSKFCSQNNDLNISLTTVTFFWDISDFISGKADTFSLSSDLIQASKNQSFIEIIESNDLETSKAALWMLLLLRLAAVTTDNRLELRKSAIQTLLRVLDAFGDQLSPEAWSICLESIVFKLLLSIIERLNFDNFAGISLSDMDKEGWYETTVLILTGLTNLLADYLDVLSKSNSFKKAWKTLIEYFDTLLQFKVLSIDTAIFKALRKLLGKGNINEGQEDNLDTEAIDLAWNLWSKSVPSSMYEKSEKPLCNQDCLLAYITVLQEIYRLIQSRLEASHVEVMLSLLRIAVQHANVELYSADIDHLTSLQTEVLNILKIIRTDIKGVPAAMISQVAEFAELAFKSRGTAALELRRPTYVALSKASMIVLEDLIVKHSSDFNIYLTGAISASLEALAKPIRIKYSFSITSKTTASWKQATSCAISILKSIVPFIINAKLQDDIEQSLWSSIVKISDGIIRVDIQDTKETTNIESDEKFDIESFLTLRDLITLALGSTKLSDDTRQKYAQSLFHMSLIHEKISSDDLNLSQESLTILSYPRKGKTIDPTPSIRSKMSYVCFDEITSLVRIHDSSEARIKLAQAAAPYLILRAGLTIQAYIVDQPLRGMIPQPLTQRKELLYILRALIDLRCEPEAIKVESESGIKSDICIGEKKHLVKLYPLLVMALRVAVRDQEVLSCLAMALDRLQKDVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEP4</accession>
    <name>A0A0B1PEP4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEP4"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="106" mass="11933" checksum="72890F65978990FF" modified="2015-03-04" version="1">MGSAIKANTEKVLKQWHPELIPLVACTDSKSLHECLVRLGTTNEERLMIDIICILQACERREITEIMWIPVNKNPADSMTKQKGICGNTLKNLIIDNKIIDIIPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PET0</accession>
    <name>A0A0B1PET0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ww domain binding protein 11 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000502">
        <property type="protein sequence ID" value="KHJ35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PET0"/>
    <dbReference type="STRING" id="52586.A0A0B1PET0"/>
    <dbReference type="HOGENOM" id="CLU_078580_0_0_1"/>
    <dbReference type="OMA" id="MPKERNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="283" mass="32110" checksum="189AE446C7665E7F" modified="2015-03-04" version="1">MIKNKSVNPAQAQRKAEKAKAIKKSKAEAAARRNEKLARRNPDRLQKQLDDLKAIENKGIGLTNHEKNVLEGLEKEIRAVRKARESLGNTLPKNDVGVRKGYENKPSQDRKDGTSSMLGKRQRREELESSEESDVPEEVKRIPMPRDTPPPIPKEILDKWYQKRRDRMAPNNRINDMNANLTPLGNNDHCTTTSIDKNSEETLLAKPIVESQTVYEAKPVIRDLRKEATVFVPTVVRVKIDKMKGVGSLIEPEEADKLETDGYLPKKNHIQINKELGDTINNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFJ3</accession>
    <name>A0A0B1PFJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sur7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000433">
        <property type="protein sequence ID" value="KHJ35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFJ3"/>
    <dbReference type="HOGENOM" id="CLU_064532_0_0_1"/>
    <dbReference type="OMA" id="YSIHVMA"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="296" mass="32522" checksum="733E447A6C7E6D0E" modified="2015-03-04" version="1">MRPLVIVPLACSVVGLVLSFLLIFAGNRPGFMKDYQIVTLNTSTLGHDILPKISKANLIPILTPEDDLLSSMSGITDQLNGIFDDIADDVVRSLGIQQFYNWHLRNFCEGMYKPSYKADNASFAVTDCSQPTASYHFKIGDIIDRELRVGPLHIGLQDLKWPDALQKNFDTLSKALHAALSFYAIAITATIFAIITGLLVLFGSNSLLLSLTTWALLGLGFFSLFVSSIIIVIVNSKSIKIVQENGSKIGIYAYKGHKYLALTWCSAFVMLLAVISFGAAIFFGRRSEKGSTEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFY8</accession>
    <name>A0A0B1PFY8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000265">
        <property type="protein sequence ID" value="KHJ35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFY8"/>
    <dbReference type="STRING" id="52586.A0A0B1PFY8"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="27988" checksum="62B6E6C9AFAB28DE" modified="2015-03-04" version="1">MSGSAGYDRHITIFSDQGRLYQVEYAFKAITAANIMSIGVRGKDCAVVLSQKKVPDKLIDPSSVSHIFKLSPSVGCVMTGPIADARAFVERAISESADFRYKYGYEMPGDVLAKRIANLSQVYTQRAFMRPYGVACTLISLDSEFGPQLYKCDPAGYYTSYKATASGTKQQEAFNHLEKKLKNKEYADGDWKDVVELAITTLSTVLSVDFKKSEIEIGIVGGPSTDKIGTTNPEFRVLTMAEIDERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG19</accession>
    <name>A0A0B1PG19_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000255">
        <property type="protein sequence ID" value="KHJ35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG19"/>
    <dbReference type="STRING" id="52586.A0A0B1PG19"/>
    <dbReference type="HOGENOM" id="CLU_481622_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="566" mass="64376" checksum="094953AEB90104A7" modified="2015-03-04" version="1">MDAATVEPIGEIASAENPLPEDSSSNDVSVDLGSGEKAALQKVEDEAIIEQSVIQKSQGEIFSDPVAEKLNLEDSSKDSLFNVDNGEKSVDVGIAIADHLMKNSMNEDLSGTKSITDDLTQSSSSKGRNSTGIDSNDHKSVYLGGVTKSYDQNRDKVSSRSYNKIDKYLGQGHTSKKSVSNHSPENKGPAGVLASFLTKDSNNSKNIDKKSENSRHRSYKRTESLTKSSREDFDGNYSNIEKSNEPNLKFQSSSSRHQKRSHHHDRHISELSSNKNLEQTPENSISYEKRKSVKRSQKSSHTQINNDSCSKENTRILLKSPEKFTHLSNIVDSLSPNESHESTSKLMDKKKKYVVKSAPFVADQKPHVKEKPSKIPPSKFPLLDRVRLSLDGDRPPITKEKDLSRHHSSSERSHQRIRDDRERYRKLAEREARKAKKETEKKISAAQKEVAAEARYLHEKEAEERRLRREKRRKRREEQDRAQDDRNSSTHLRRSQTQTKVSKSKSHRSRDNVKHCSESFPRSHSEPRPEKTSEHHQPYTSSRVKEKEKSRGALRFLWSTAKKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH60</accession>
    <name>A0A0B1PH60_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="JNVN01000232">
        <property type="protein sequence ID" value="KHJ35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH60"/>
    <dbReference type="STRING" id="52586.A0A0B1PH60"/>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="OMA" id="HSPQMED"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="369"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="551" mass="61720" checksum="C93829F4587F86C4" modified="2015-03-04" version="1">MEASSPLAALRAPCHIPTWGGSDMFSSHSHNQFASNIFGPGAFNFQDLPIKKSGKPDYLKNNQNRGCSPTASLAADLSQNFHIDMSPQLPTPRRSLFTSNLFGSINTHASVATPHPFSSHMGGLDENMEISPLPHKQPRYTLNGMKSPTPGNSQQEKILPSSPPQHSHLGGFRHPNCGVERKKSLLARSGMSRGKSLSVNLMPSKKSENQPPPFLFGAGTSKLSSSTSISLDECFLDSPPRETHSQSSFSPRTNNNCPPRLGKPFGSANTANTRLTGSPVGHSSKRPSNPMVRPRKQFRRSLSMFEHPDEMIKSKQEEESASNLHTVIDIDELQKPVLPHFFQEGSPDSIPRISQETFLQILDGEFTDEFERKIIVDCRFEYEFEGGHIDGAVNYNDKELLAGQLFGSPDPRKTLLIFHCEYSAHRAPIMARHIRKQDRACNIEQYPRLTYPEIYILDGGYSAFYARNRNRCFPQNYIEMGDKDHTYTCEREMGRLRQNRTKFSRAQTFAFGQSPIDDSPTAPNKCRNLTKMDIEMNGVISPISSRRLVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHL6</accession>
    <name>A0A0B1PHL6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative udp-galactose transporter like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHL6"/>
    <dbReference type="HOGENOM" id="CLU_874916_0_0_1"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="237"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="318" mass="36115" checksum="C06DCB4D7C99E3B8" modified="2015-03-04" version="1">MADDNQPCETTVIDKSSNYSTNVLKDNHPAVIPIGESEEDAALRQLMLQYETLEVGAVVAELQIEDDSDESSNWSENCSDQEEVSNSDEEDEFGRYTGRVVSDQLRQQMKELEGRLGKEMNKNISDKSSDFKIVEEGIGRIAIQDEKNNTLNPKKSVRFSENPEISLFSSKLPVVETVNHKPVERKFAPVNDIVERNPLESSSITKNATKLDFKEEKSDLATRVDCSKTNISKKSLLASTIIERNTSFGNLYDEPDEMNSDLMRQEVASQYYKMRNMFIQRQGGFMKEIERERVEFTEEEGGPKKISRFKAARVALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV62</accession>
    <name>A0A0B1NV62_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60s ribosomal protein l38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004689">
        <property type="protein sequence ID" value="KHJ30237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV62"/>
    <dbReference type="STRING" id="52586.A0A0B1NV62"/>
    <dbReference type="HOGENOM" id="CLU_152057_1_0_1"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="83" mass="9637" checksum="6EF1E62CBDBDED0D" modified="2015-03-04" version="1">MPRETSDIKQFIEICRRKDASSARIKRNKKSSQTKFKVRCQKYLYTLVLKDSEKVEKLKQSLPPNLVIADTPKKNAKGKRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVN7</accession>
    <name>A0A0B1NVN7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">EV44_g2127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01005549">
        <property type="protein sequence ID" value="KHJ30033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVN7"/>
    <dbReference type="SMR" id="A0A0B1NVN7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVN7"/>
    <dbReference type="HOGENOM" id="CLU_037990_0_1_1"/>
    <dbReference type="OMA" id="MNDVMSM"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="33747" checksum="FC33F3A20F07A20C" modified="2015-03-04" version="1">MNSSFLRCLPQFLRPKYSTRWLVNSRSYSSIENERKTHFGFQTITETEKEARVASVFSSVAASYDTMNDFMSLGIHRLWKDYFVRSINPGFSSCKPPRPWTMLDIAGGTGDIAFRLLTHCDQINHSKESTVTISDINQEMLTEGRKRSLATSYAQSPRLKFLLANAEHLDGIPSNSIDLYTVAFGIRNFTNIEAAIAEAYRVLRPGGVFACLEFSQVTNSVFNSIYKRWSFSAIPLIGQLVAGDRDSYQYLVESIERFPRQDVFRDMIAKAGFEVPVEGWENLSGGIAAIHKGVKPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVP7</accession>
    <name>A0A0B1NVP7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004269">
        <property type="protein sequence ID" value="KHJ30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVP7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVP7"/>
    <dbReference type="HOGENOM" id="CLU_045202_1_0_1"/>
    <dbReference type="OMA" id="WNADGRH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="37959" checksum="D9787BABF4A6B97F" modified="2015-03-04" version="1">MAPLPRQRLSSSIGKGNFSAYLTNLKTQSYHEPSVSRITISHSIRSIAWNPLGTLIATGALDGTVRVWNPEKPKSIYSTELNLSSSKGHHRSGIEKVSFNPVKDAELCSVSSDGIVKFWDVRSKAIINEVKGLGETFTLAWAPNGESLIVGNKADNLFILSPTQSTPISSHQQNVQTNQITFCYSGKKIFLTTGEGRVKILSYPAFEPVYYLRYSPSEPFTINGHTSSCLTVEMQPNARFLATGGSDSIIALWDTTDWICQRTLIDMTGPVRSISFSFDGSYIVGGSDEGTGLEIIHTETGEQVHSIKTPGGHPCTVVSWHPSKYWLAYTDLGGLKILGVDIIGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWC4</accession>
    <name>A0A0B1NWC4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative nitrogen response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003766">
        <property type="protein sequence ID" value="KHJ30677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWC4"/>
    <dbReference type="STRING" id="52586.A0A0B1NWC4"/>
    <dbReference type="HOGENOM" id="CLU_347548_0_0_1"/>
    <dbReference type="OMA" id="YPLCNAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF338">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="653"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="707"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="812" mass="88951" checksum="D0FFBA10CFF30CEB" modified="2015-03-04" version="1">MSVEMYYEKSQSNPVASMETLTTEHDFRFPRRPMSSEDTITASIPHGVTSNFKSNVDGSKNPEIVLGPDHLKMLNSAAEIKTRVNMLHGSFFPNGKGNPTSVDPGPTGELCKKDSLTAQILGLYSDIKLNLPNQERMKNLTWRMMSINLQKTRVQATASSSNSSSVPSGIAQLRQSSSQIVPVTSSNALGHLDIMDVDGSFEDETNKYKPNASRLSLSLPELEIQEMKRNSNTTACAIPIKTSAAPTNFPYHHSVQTPRLSSRSKQEFGYINRHIRKTSIDELMRPRKRHAHFSPKMVALKNSSLSFDNLHDFSLDYLQYSKILQSSMHSPNFAHEFVDNMDFDEVTTSGSSCPQETFFTPQLLAAQQSQFPSHFDSSPIELPHLKCENHYSPTNSNLQSTPSTPKATTDSEQIFLQSLQLDPQYNPQEFQHNQSNLSDSIGIHYTNNKSSNPIFSPISMTNSTNSFSNSSNSCSTPNVDVSSKMYSNEHSALIPNIYDKCIDMGTNGFQWESNVPYQLNTNISLTGDLSEASLTGSANTNLSSSTNWDSAIRSSCSSHPSTPSILENYSRLGNIKTIPSNPSINILDQDSSIFDHSNQIGLRSSLPGSPVDNINVTGNSSTATSRPSSPTSKTSRINNSHVLSGQSQLNGENGVPTTCTNCFTQTTPLWRRNPEGYPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGTGPSLTLNGNGVKTSKKNLTSNSNTFGNLGATTSNNRKDGLDTSKSIFMPASVQNSDMKSSTHSIGLHSPCSNSRVSTSYTNSVNPYAGLSFESLNLVCMNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWP6</accession>
    <name>A0A0B1NWP6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003645">
        <property type="protein sequence ID" value="KHJ30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWP6"/>
    <dbReference type="STRING" id="52586.A0A0B1NWP6"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_4_1"/>
    <dbReference type="OMA" id="TIRTWPL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="42772" checksum="D65A0DD746F0D719" modified="2015-03-04" version="1">MNRSSDPGHFFESDASKATRARKATKSINNNGNPISLQSKILHVILDPFSSQHVYVAESSGCARKVNIKNRKETKVYRGPSAPVTSVAIACANNSILFGACWDKKIWSWDLENDFASKTYIGHSDFVKTIITTKLDGKNILISGGADAKIIIWDIATGQRLYTLQDMQSNMLSLQDLAVDSHASVESQLIVFSASSDPVIRQWCLGSSAGKQILDPKHCIHENETSVYKILFSEDEDSHLWTASADGTAKCLSRIRNWTTEEVYEHGDYVNAVEVSEDFIITAGRDENVKLWKRDTGELFHVYEGHFDQVTGLVVTECGKSVVSVSIDGTVRCWPLEKGEIEKEIKKKKLSVHEGQEKDKVDIPKVHMTAEEMAELAELMETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYK5</accession>
    <name>A0A0B1NYK5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002871">
        <property type="protein sequence ID" value="KHJ31467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYK5"/>
    <dbReference type="HOGENOM" id="CLU_1367136_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="21968" checksum="608403E5F1392BF7" modified="2015-03-04" version="1">MPNIVEKKSNSILGLYLIIGGQGGRTGLVFAVIGIFLLILSLFVLVVRLVAIFTNSAHLGNIGWGFRPDLCKDLHDLEMGWDMIETTELSEAEKVVQKVRKRREFTARVNLGHLESFSHSSSSPQLPAPSWSQSSSFTSGSVLITRKNQTSLERTAYGIDKTGLKGKHRGEMSDTAANSLDEGTHQRILESDKVNGNVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYR4</accession>
    <name>A0A0B1NYR4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01002811">
        <property type="protein sequence ID" value="KHJ31542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYR4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYR4"/>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="OMA" id="WRVNACD"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="427" mass="48468" checksum="9B96636F7A87DCFD" modified="2015-03-04" version="1">MENFIIGIIGMGNMGVMYAQRLSAAGWRVNACDREEKFEVLQEKFADNANVKVFPNGHLVSRASDYIIYSVEAEAVERIVSLYGPSTKQGAIVGGQTSCKAPEIAAFEKHLPEDVDIISCHSLHGPKIDTQGQPLVIIKHRASEENFKKVTHVFSCFKSTLVYLSAIEHDRITADTQAVTHAAFLSMGKAWHANKQFPWESARYVGGIENVKINLTLRIYSQKWHVYAGLAILNPYAREQIRQYAQSVTELYKLMLGGHRQLLEQRIRTAGEFVFNNQCSQMKPPLLQDEILDRFSLGKKAEIPLPNNHLSLLAMVDCWSKLKIVPYDHMICSTPLFRLWLGATESLFRNPTLLDEVLKIAIEDNTFRSDDLEFTFAARGWSDCVTFGDFRSYRDRFESTQKFFESRVDDAIRIGNEMLKTILANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ90</accession>
    <name>A0A0B1NZ90_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004477">
        <property type="protein sequence ID" value="KHJ30325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ90"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ90"/>
    <dbReference type="HOGENOM" id="CLU_1138730_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27789" checksum="EFD1A47609C6B4DF" modified="2015-03-04" version="1">MANKLPEDNTSSSTFTIKGIMPNKLENYPILTGSDDYQDWASTWEIGFDMMGLKEVLVGEIPQPQPKTTGWEEWNYANKLLRGYLVSAVDKTLRNMVTTQLTAKDAWFNIKARYDRETPATTLSLLRNLVDLKLEENGNVADHLTIFTNTWDRLYQRSLSSTSNVAKAFRDVTSSDEVKGAFLLLSLPKNMDYIIDNLATKDLIKFQDIQPKLLDLSADRNVSYTENQAYHGSAQNQEINEYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZC8</accession>
    <name>A0A0B1NZC8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003020">
        <property type="protein sequence ID" value="KHJ31293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZC8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZC8"/>
    <dbReference type="HOGENOM" id="CLU_003637_1_0_1"/>
    <dbReference type="OMA" id="PRRDNEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="266"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126618" checksum="A60FBF150908A063" modified="2015-03-04" version="1">MVSQEATQPATQIVVDPRRLGQQDPDLSPEDLADVCCILHPNSEPARKACCLIRQLTPQHTIANGNTLRSQEPGENDMNHLENKYSYDIALRLSSQLKFPSNGGFYFGRNPKRCDILIGKDASKRISNIHFRIYINEYGYLMLEDLSTNGTAVDGILLRANMKGNGIEYQHVLIHGSIITLAMNLPEGEDDYRFIIRVPSRDSIAEEAYQQNLRKYFLQINLAKNENACKLSSGILHKDPGLDLATSAISKALGRRSKEWNGGPKYNKVNKIGKGAFATVYLITSKYDGVPYAAKELEKRRFMKNGILDPKLDDEMKIMQKIKHPNIVEYIEHINWDAHLYIIMEYVPGGDLGNFISQYGSLQEHNVKMIAVQLLSALRYLHQKGVTHRDIKPDNILISSYSPLEVKLTDFGLSKMIESEETFLRTFCGTLLYCAPEVYSEYREFDQNGRRTLRVADKKSLPPQRYGNAVDVWSLAGVLFYSLCNAPPYPVQNGESYLDLLTRIMGQPLDIRPLQIANTSELGIRFIQSMLHNKPAYRATIEELQNSSWLIEVEKLDTSNKSQIERCKDENVFLHLENSASQLRIQDNKDRVYNSDELNELMKIWDTDSEDLEVSCSFDTSNGLAKLVDTYQFSGKSIQERNNSCLLGKLSSIIGSSDVIPLDSLGPLLSTDQKLKASVAELPGSFRSDKFNPENQIISFQDPVILQDFSILKEPKDNKIECSSLFGAESMVGHLNVCSPISLNTPTSDVIKKPEIWTATASLRRPRDEDSIAVYFDTKRRRGNLQNSLASISKSHWDVKDNPTANPKQISFFSSELQRHWEDYQSSDKNTLHGQDEILKKYAGRKNICSELLPFIQVDSETSNEKGHKNLVEKGNNDTCTSSDDNLHQSNAIPQTAYKNLKEEQKESLKNRPLYLGPIIKNAKNKIVLAKLISSSDSCLPNITISLQDYLTTWGRGSKAIIRYPDVTENRIPKYAFKILLYKEDFYRTSRDYSSNAFSLDDEDPDMKFYISTKASVGIWINDTNLPSHDRQNPNTESKYWGQLKHGDLITVWRHDSKPKQIFTRFRFECYWGKSKKIREPGDQFMLIQNKPYLKDLDITCRKLEDLAFTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZK0</accession>
    <name>A0A0B1NZK0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative nucleolar essential protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005122">
        <property type="protein sequence ID" value="KHJ30106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZK0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZK0"/>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="OMA" id="VHNTFEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="271" mass="30325" checksum="A7F4003E30646933" modified="2015-03-04" version="1">MPHKIEANYGHPSPKNRDQSIKPRRTQSLPPPSLPQLVAEQHVPIPSTDKESQRLIVVLSQACLETYKASYGGNLPGSHREEKYSLLNSDEHIGVMRKMNRDISDARPDITHQCLLTLLDSPINKAGKLQIYIHTAKGVLIEVSPTVRLPRTFKRFAGLMIQLLHRLSIRSVNSQEKLLKVIKNPISDHLPPNCRKVTLSFDAPLVRVREYIESIPDKESVCVFVGAMAKGSDNFADQFVDEKISISNFSLSASVACSKFCHAAEDVWNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZK1</accession>
    <name>A0A0B1NZK1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002935">
        <property type="protein sequence ID" value="KHJ31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZK1"/>
    <dbReference type="HOGENOM" id="CLU_797389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079592" evidence="1">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="348" mass="39960" checksum="97806E7970D13341" modified="2015-03-04" version="1">MQHQLILIAIAVIFISITSSTDFWNVQTVLTEPVYYDCGSWVFYEENILEMLSSLGENIDQLGQPFIEPLYNLRSGYRKVFIPQELCKGNHVPGPRQECHFFVIIDQMAQIVDVVSQMNNGYFIKCIRVDQLVPQPPPTNLNDCNFECGHEIISNKVVHLSQTRAISKIGHSDSRGTQYHGNLYTPVLNYWIYPISENFPKKPTALEPKYTYYIVLTPFGEIKDVIAKLMHNDFMKCACTTKAPDDSLDRNLEAGFRCGTKFIGFKHVKRTALHAKRYSSKTNRLDDFPKPYDGPGSRLGQSMFPILINGRFYIGGVGRMYRYFLVLNPDFEIEFVVTKTPESYRLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZK6</accession>
    <name>A0A0B1NZK6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative duf1237 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004172">
        <property type="protein sequence ID" value="KHJ30475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZK6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZK6"/>
    <dbReference type="HOGENOM" id="CLU_023537_2_1_1"/>
    <dbReference type="OMA" id="MRGPVIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="445" mass="49579" checksum="E2E892BA7D323FEA" modified="2015-03-04" version="1">MKNVIKDPDLYRLFENSFPNSLDTAIKWKGVAANNSKEELAFLITGDINAMWLRDSANQMQSYRSFLKADSSSDSLASLFRGVINLQARYINLAPLCNSFQPPVESGLNPTKDHDTDTVYPPPDADQVFECKYELDSLAAFLQISTNYYEATQDIQFFKDFQWVSAVQTIITTTESLMKGTYALDGSVNKCPYTWQRQTSSGSETLVNSGCGNPVKGDIGLVRSAFRPSDDVVIHQYLIPANMMFASYLDSASKIVAILGTEDDLADLMHQFSQSIRAAINKYAIVPDAKYGDVYAYEVDGFGSVNRMDDANIPSLLSAPIIRYINKNDVIYQNTRRYVLSKDNPYFMRGPVINAIGGPHVGPGMAWPMASIVNIFTSDNDTEITSALREIVSSTAGLGLIHESINSFDESRWTRQWFSWANGLFGECLLDLKARKLGVLDQSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P061</accession>
    <name>A0A0B1P061_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002719">
        <property type="protein sequence ID" value="KHJ31628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P061"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="374" mass="42664" checksum="54C2581BE2A126EC" modified="2015-03-04" version="1">MQHRKHSSCLQKRHRIKEEDDLVKNYLQQAITLLAASDNASKSPPIPHLTKPLKTKGFIQGKDLTKNKAPNIFLNTLTSQKESQPRKSIPEDHFEINKVQQNSWVMIARNGHKKSRAQQSLQNPMNNTKPLQHHLPVQSPSIMRNSKNSKKSNLDKSDSRLFVRLPLEHEWRKLSPAGIREVIVKRLSISPASIGLIKPVRIGLGGLFLSVAKLEPATQWIPLLIPTVLKTINTLQGRKEISKLMLADEIERVSSVRPEAVKLNGYQKPDAMHRTWLALFTQKPKPGFRVFDESGISSIFKKQTPIEFCKRCNRHYSSKSTLEHLHVENMGQLCTLKVYIWLQRGVEIVEGLIGLTVENVSHAQRVMELRQKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P080</accession>
    <name>A0A0B1P080_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003754">
        <property type="protein sequence ID" value="KHJ30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P080"/>
    <dbReference type="STRING" id="52586.A0A0B1P080"/>
    <dbReference type="HOGENOM" id="CLU_009650_0_0_1"/>
    <dbReference type="OMA" id="FPDAVMG"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="92183" checksum="A68AC03BB440A555" modified="2015-03-04" version="1">MALDMEKYDYDEESSDDDLIPSSTISSRRDSSGSQTSYKSLLTQNLSASLFKSRQDSRRRTLRRRLPSRISRYLGFTLIFILIIFILSLIRASAISSRNVEEGKFRNTLSSPSESWRSFPFLTRYYGGVRSLTVSSRNIPEYPLPNTKENIFLHSNFSIPIQELPNSLIFEAYSGNSLVGNISGNIPKQKCYIDVASKTLIPQIRYYKGRPFGFPDNVMGSYEILDLPEDICFERFGRLGPYGYGYMPQFGGTGTGEDGDKEGSKALWENGSEFNQIDYRNINWANLQRECYNVNKARFKQDRPDFSFNTIKTFSVFDNQVDEEKKSESNTSVIPKNILERSAVVVRVWDDFDYHEEDILNLRAMISELSIGSGGEYDVHLLVQVKNEGANPIWADSETYQRHLNESVPLEFRDISTLWSVTQMLMLYQGIFDTFTRGPDLPIHGPYRGLQMAMQYFAHIHPEYDFFWHWEIDTRYTGHYYHLFSQVEAWSTRQPRKGLWERSGRFYIPSVHGSWEDFKHTVRVQTEIGTLGPDNIWSNIEGVKARPKVDKPIWGPKRPKLEEDWFITEDDQIPPTSYENDKYQWGVGEPADLITFNPLFDPNETTWLLATDITGYNTSEGLPARRASIITSSRMSKRLLQIMHRETAFKKHHAFSEMWAPTVALHHGLKAVYVPHPIFTDRQWPTEYLAGIMNAGKNGATGGARTSVFGAREHNFLGMTWYYNAGFAPNIWKRWLGLKVNNDGGVEFELSVDESKNQSGVGEMRGGEGRMCLPPMLLHPVKGIKLPVEGSVVTKMDPPNISPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P081</accession>
    <name>A0A0B1P081_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002381">
        <property type="protein sequence ID" value="KHJ32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P081"/>
    <dbReference type="STRING" id="52586.A0A0B1P081"/>
    <dbReference type="HOGENOM" id="CLU_018142_0_0_1"/>
    <dbReference type="OMA" id="HPPRYIF"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="127"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="549"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="743" mass="83523" checksum="1F3D75619A30B801" modified="2015-03-04" version="1">MAYRKRKDLASIRRRVEDDGDEEGGPDVRILDDDSFSEDSIQEDNLNDLEDNESQNSGYVSSTLPQPGELLSRKRLEQRNSGETKKLNKIDISTSRAASNSNSDFYMMINGSKLPEDIRTMSGAHFDELGKDNRTQHLPDATPSITHEKHLFEKFQDKRKREHEEYKNKRFEDPSFVPNRGSFFMHDHRHSGSAANGFRPFTRGRGRGKLGSVSTFVHNSTNHSHDPSSVQWTHDMHEIITQPVKPNIHKEDSQNISNSHPQATENPIKDESLSRTLSVTKSLGTVQIRVALPKMPKPIIFPKISFNQYTRLPDHRPPLRRDKPVRVSLPNHPTRYIYPTIDRSFIFIPRALRPNQQGFGGRGRGRGKSVFGSGGGISRRTSVFDGSMYGSAYSPSVAMSRRSSLAWEINKEALSSPTGSVLSRHHIAFGSSKPVVRLPPSKLDSQLPIEVLSPPKLDPPSLRPNETSPTQDSRLKLNKQLNNSGHNSSIVTHSDNNYQLPEQNSVPLDSTSKDYEQKIDNISPLEIRERNANLDVKSPPIARLDPHLQAQQPSQNQVSGQVDASNYSHDGVLNSRDISYPPQTSNRTPLSRIPERAIHAQAFQPNIYQSQQIYLQPYQAVPQNHSYFCPPTYNSTLSQPSNVPAYIQIPPQQSQPLPIPHTSQTENPHSQTGIQSLIAQEINGMVYYYDAAQIPAIAAYPAYPQPPSYPIQQSGFVGMEMIGPNLDGYYYTNAPQEIMYHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P096</accession>
    <name>A0A0B1P096_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01003723">
        <property type="protein sequence ID" value="KHJ30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P096"/>
    <dbReference type="STRING" id="52586.A0A0B1P096"/>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="OMA" id="WKTTRIT"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="24672" checksum="BF9925165C6B0CE1" modified="2015-03-04" version="1">MGTQIRSYQRISVKNLFLGIAFTTILSLIFTYLDTKLENFYIFTPDYLHDLSKRAISNHGNNTRAIVSELTRELSEKFPGGYINLDEEWIFNNAGGAMGAMYILHASTAVGTEGHTGRHTADDYFNILTGVQLAYTPGSFEPEVYPQGSVHHLPRGNVKQYKMENGCFALEYARGWIPPMLFFGFADGLSSTLDFPTLWRTTWVTGKQMILNLARFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0B5</accession>
    <name>A0A0B1P0B5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor spt20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004499">
        <property type="protein sequence ID" value="KHJ30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0B5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0B5"/>
    <dbReference type="HOGENOM" id="CLU_004682_2_0_1"/>
    <dbReference type="OMA" id="EKIMRLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="128"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="712" mass="79290" checksum="39F50B3A33FEF2CE" modified="2015-03-04" version="1">MAPLTTGTQPITSKLKRLVPSNIQTNDIQSSITSTSPSTSENRLPNSAKPAINSAGSNNPENGSPSIRSAGRRRDVFNQFFGRNLRKNSIGLRSGCSAGESVILMSNDPPPYIKSDEYILKKYRNNIPSLVIHLHPTHFRFDNQEGHFPYQSPMRLMIEHLRQRTIPHDLVEYFGDIPYYEDCLIVQVHDHKSIASSEPPEREKSPEPKQVLFSVHNYSQYCTPSPYMQYMVQTSSLKKPKRLSEKSKNDKSESQDTENSSITISSPQKPKVSTVVLHPTNLSKFVNLAVKVAETFLVDGKSNCQPETNGAVYLSLPSTPLLSFPSTSQTSMPPPAKRIKKSKMYLNNNNIYKIESQINLGTTAPLFLEPVSCGFESAILIESLAHPMHEEEPPAPKIRKRTVAEMAADEAFAAEQERYMLLLDERLSSNVIAGPVSNASSGINIQSGGIQFEARFERFKLIESLRAQYEEKKRLEKLKIAENEKRQRLESGKSRLKDDAEKRAEQERKLAALSKQAQVHAQLPAENNRSRQTQVERICSDQQSNQGHQNQSQLQHPQSKHIQPPHAHPQNGGSSATISGQTQRFHQQISHTQSPSPVIRTRTPQSNCSPPAQSINAAPMQNSTSNMGGSPHQGSNVQQTPQPKIPPTSHVMTAQRSQQNNNSSPRITSSTTAQSTPISLPSTQTPRISQASPLQRHIAQASHAPRYFNNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0U3</accession>
    <name>A0A0B1P0U3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative amino-acid transporter arg-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004040">
        <property type="protein sequence ID" value="KHJ30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0U3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0U3"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="301" mass="33235" checksum="B856ED6AA5E9F0EF" modified="2015-03-04" version="1">MDALEDIVFGSVAGAVSKYFEYPFDTIKVRLQSQPDRLPPLYSGPLDCLRKSIKSTSGSTITKLLSLYRGVSTPVVSAVFENSSLFFWERIAQQGFRNTGLFNHDEKLPLPALWLTGATAGAATSFILTPFELVKCRIQAPICRRTDYSPFAIIGDIWSHGGIMGFWRGQASTLIRESLGSAAWFGSKESVSTLFRIINSNHNELIPLPLYQQVIAGASAGMSYNLISFPADTIKSRMQTSGLGVDKKSIWSETKAVWRHHGLKGYYRGCGITVMRSAPSSALIFCIFDGMKVHMPLSRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0X6</accession>
    <name>A0A0B1P0X6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002521">
        <property type="protein sequence ID" value="KHJ31873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0X6"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="28456" checksum="A5EA2816F47EC460" modified="2015-03-04" version="1">MLTCQYREHIQTHQGATANKNIKNKAVTQNSWTEIVRRKPAKNVVDLQTQEKVILPPIPLENTPKVISKPDLRLFLRMGQDYPWRRASPHYIKISLAEKLKVASSAITQVTRVNSGYVVTAVSEIMRNALLTQARRLEKSELKLEPASKWVSLLAPNVPDKLFSISGTVPTTAEMVIEETTLKTGIRPTSVRAIASTSESPTSNWILHFATGVPKLGEKLFGESGRLTEFQRKPRIGQCDRCHGHHPSKIYSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y3</accession>
    <name>A0A0B1P0Y3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pre-mrna splicing factor ini1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003428">
        <property type="protein sequence ID" value="KHJ30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y3"/>
    <dbReference type="SMR" id="A0A0B1P0Y3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Y3"/>
    <dbReference type="HOGENOM" id="CLU_110369_1_1_1"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="108" mass="12313" checksum="8CAD3AD4ADC3E639" modified="2015-03-04" version="1">MSRHHPDLVMCRKQSGISIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGSEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKNFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y7</accession>
    <name>A0A0B1P0Y7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative swirm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003424">
        <property type="protein sequence ID" value="KHJ30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Y7"/>
    <dbReference type="HOGENOM" id="CLU_042442_1_0_1"/>
    <dbReference type="OMA" id="RWASNIV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="233"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="37489" checksum="1CB621E01C94C2EA" modified="2015-03-04" version="1">MPILNNSDIASFTSSPAVFSLPIERPQKSIFSKPLQKYSIANKKNELGKMPLSPPVSPETKNINLRDARIFMNFPKFSQVVPSALENSSESVAKNFRIPSPPHTSEYRLALEFKSQLRKAYGANHRKWAQRELAQLKEDIRLRSGDCCKKESLVKKSISKEQLKTKKPSICQSVTVGNNMSTPRVNKSRIRKNTQRGERTEGSKRVLREDKDFLSITDYCPPLSSLPNIVNCLKVEWKGTGINLSSDPLAHLLHPEEIQLASNLRLDCATYLTSKRRIFVSRLEAYKAGKEFRKTDAQQACRIDVNKASKLWQAFDKVGWLDIRWASNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P123</accession>
    <name>A0A0B1P123_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative voltage gated chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003364">
        <property type="protein sequence ID" value="KHJ30995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P123"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="880" mass="97930" checksum="85D6BC6BD782EF6E" modified="2015-03-04" version="1">MRSDNEPPAEINRLPGESVIEITSDSGFSADKIPTNRPRLNTQNSKFLSFNKVDERVPLLGPRLRRSQHSQTWRSSSDVASSLRHLSPRRGSFRNSFNSQTGVTSAAFTSALCEENSIKKSHGLEDIYERAWYDQFTSTDWVRDSITDAHRVRNLSCRKDIRGRLKFFFDGYEGYILSAIVGFFTATVAYLINVSETHVFDWKEGYCLNGFFVTHKQCCPKNNLCDDWKSWSNLFHLPYISEETLNFLVFVFSVIAYSTLACLLTLSTKITIVPSYQTTRLDHNFDASNGYGSSNDIVFSKSNAEESVIPMSFYPVAGSGVAEVRVILSGFVLHRFLGVRTLVIKSLALVLSISSGLSLGKEGPFVHIATCIGNIACRLFSKYEDNDGKLREVLSAAAAAGVAVAFGAPIGGILFSLEEVAFFFTAKTLFRTFFCSIIAALTLKFLNPYGTNKIVMFEIRYVRDWQFFELVAFILIGILGGGFGAFFVKASRLWAYKVRPLMKNWHLLEVFLVALVTGAISFWNPLTKLSAVQLLYNLASPCGLDRPQDLGLCPLSEDKIILTIYRLITALLIKVLLIVTTFGIKVPAGIYVPALVIGGLGGRIIGHLMQILVMRFSTLPIFKNCAADTSGLSCITPGVYALVAAGSTMCGVTRLSVTLAVILFEITGSLGYVLPCSLAILVAKWTADAFEPQSIYDLLTEMNFYPLLSNKEKPVFLSELSEIVPRARREKVVDISNSPLVMASNLQSKLELLQKDGEFDGALPIIRNRMLVGLLPAPDLEFALDNIEDKSKNLFLMSKTTASNEIEIERNHDYTDISQIIDPAPLSIDIQSSMDLVYQCFLKLGLRYLCVLQEGRYVGMIHKKAFVQYIRQISEKKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P164</accession>
    <name>A0A0B1P164_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003317">
        <property type="protein sequence ID" value="KHJ31035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P164"/>
    <dbReference type="HOGENOM" id="CLU_1338410_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="205" mass="23132" checksum="9B5B924E6075553D" modified="2015-03-04" version="1">MVEVEVEDGMTYESNLLDANIVETRKRQRMDRGDGKDIIDDDSSVNDLTHTARSRPPNSEANCTKLSHLGSEPKQIRRKKLSKIHAFSGKPPLDSNFYIELLSRVKVPLSVLEIAQISPEAALHWKRLMTRENSRKKKTTGIDGNAVEIEEDLLNELYDYLKNRAESNKVIVLNIRDGKITLKLVISEIGNKQIGSGKVGQTKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P175</accession>
    <name>A0A0B1P175_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003308">
        <property type="protein sequence ID" value="KHJ31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P175"/>
    <dbReference type="STRING" id="52586.A0A0B1P175"/>
    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="174" mass="20675" checksum="9DCD235180E89C35" modified="2015-03-04" version="1">MGRLTEYQVIGRHLPTETNPTPKLYRMRIFAPNTVVAKSRFWYFLMKLRKVKKSNGEIVSLNVISEKRPMKVKNFGVWIRYDSRSGTHNMYKEYREMSRTDAVEALYQDMAARHRSRFRSIHILKVVELEKTNDVKRPYIKQLLTKDLKFPLPHRVPKTASRNLFASKRPSTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1G2</accession>
    <name>A0A0B1P1G2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4618</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="EMBL" id="JNVN01003227">
        <property type="protein sequence ID" value="KHJ31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1G2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1G2"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="NRYTDLN"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="41123" checksum="939EFF095C25D078" modified="2015-03-04" version="1">MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDNLTGQNVAVKKIMKPFSTPVLSKRTYRELKLLKHLKHENIISLSDIFISPLEDIYFVTELLGTDLHRLLASRPLQKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLENKPLFPGKDHVNQFSIITELLGTPPDDVIHTIASENTLRFVQSLPKRERQSLKNHFKNADPLAIDLLERMLIFDPRKRVKAGEALAHEYLAPYHDPSDEPVSEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDSESQPIDDFTKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1K9</accession>
    <name>A0A0B1P1K9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sodium calcium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003737">
        <property type="protein sequence ID" value="KHJ30704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1K9"/>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="OMA" id="WNPFRHV"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="180"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="416"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="567" mass="61465" checksum="132859F7D784AAF8" modified="2015-03-04" version="1">MANIKNFTAHRLQRQARKEAWYGNSGNSWNPWKKNMRSKTWSNTVISDPEKGVETDGSKSEPATRSQNVEVDNETQSGTIENLNSTMRAETDAEIANQLSPTSSSPRLRHGKTPQNNETGEGSEDREILEKQSWFKGKALKHKPFTLKNQLQATIFNSWINILLLAAPAGIICNYVGVSGTIIFIVNFIAIVPLAGLLSFATEEIALHVGESLGGLLNASFGNAVEIIVAVIALSKDEILVVQTSLIGSILSNLLLVMGMCFLFGGLRRSEQYFNETVAQTAASLLALSIGSIIIPTCFQLFTTNGDDKIMRNIASLSRGTSVILLVVYAAYLYFQLHTHQTIFAMESQKVAMKPRKNTLARGSISKVFASAGGIGAGAGRPSLTDRPPRDELFKMDALEADKEEPEEPQLHIAVAWATLAGATAIVGLCAEFMVDGISSITKSGHISVEFVGLILLPIVGNAAEHATAVTVAIKDKMDLAIGVAVGSSMQISLLVIPLLVVIGWIMGKENMTLSFDGFQVAVLFVSVLLVNYLIGDGKSHWLEGMLLMCLYIIIAICAWYYPVPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P277</accession>
    <name>A0A0B1P277_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002136">
        <property type="protein sequence ID" value="KHJ32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P277"/>
    <dbReference type="SMR" id="A0A0B1P277"/>
    <dbReference type="STRING" id="52586.A0A0B1P277"/>
    <dbReference type="HOGENOM" id="CLU_1373123_0_0_1"/>
    <dbReference type="OrthoDB" id="3597759at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080426" evidence="4">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="194" mass="21601" checksum="D010D42BCA9F5BAC" modified="2015-03-04" version="1">MRFFIEAIVSTLILSPISVLSMETGNDATEVAADIADGPTLSGLPGVADFDLSSASSPSLEKRLCFRRGCNKKSKHASGFQCKKKHFSLAAVEKAKAVACAKIKENKQRNAFPALYTATDFETPGPYLEWPIKRNGRFWNNLRRGRYRIILTENCKVVGAVIRKSNGSYRTCKKLSEKDEDEVDDDDEKEESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P298</accession>
    <name>A0A0B1P298_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Abc transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002871">
        <property type="protein sequence ID" value="KHJ31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P298"/>
    <dbReference type="HOGENOM" id="CLU_042303_1_0_1"/>
    <dbReference type="OMA" id="LWIFSWP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42999" checksum="A8CF72E7166326E2" modified="2015-03-04" version="1">MPSYRDEGKGSNDLLLDKRLPPYQDIPDGLPKGARVECMNVESNLSPPDPAHSTKNLASSEIYTQFQKYSHDVDALHSLVNEQALYPPTYYVQIHGKHNETQYDSNSKESQKEVTDFYFRINITHLLGPRGSGEIQFLTDNKRGYRGTRYPSLKPKLSDWESRDALFEWCQKYVSDTAMIKSFALSRKIQNHDTKKLYRLIRSTIIETNYRGQVFITFPSTHSKLIVYSPGKINEWRTKTWIRWIFYITFLWVLAWPMLIFLTSRYETVNCVFFYANTSDSSDPNRTCKVQSEDEWFESWKQAIKRAVLNGINIGEQGSLSDNYRIASQTLFRDNHAIRSGNRLVDEANIFDSNTPEVTRDLVYDWGGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2B7</accession>
    <name>A0A0B1P2B7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1127</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002855">
        <property type="protein sequence ID" value="KHJ31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2B7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2B7"/>
    <dbReference type="HOGENOM" id="CLU_003574_1_0_1"/>
    <dbReference type="OMA" id="LICNERN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="977"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="977"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114504" checksum="2228167394444A02" modified="2015-03-04" version="1">MPPDIRSFFGDKKLTSNQNIEDAEVKGAKKKRSKVRRVVDDSDDDQTPKRSTSQNTLKNKVKTESIQYEEITASDYFASTNGPKTVTACSTQIKPRDSQKLKAENASLCRNVPTTFHSNFIDDDADLEILDKSNVANAALNSDLNSLDKLKDGENTKIADNDEKKNLSKLLDSKIQDSKSSLSGRKDVVRDISPLSELDKNHQFSDVDNSKEISNSVKQKCSKSLRKSRTPPEIKSESTTVQSILDSISTIRAPTPPPKDPNAKWDWKTAQAGGNNGPPLAAGSKEIPEGKENCLSGLNFVFTGLLDTLAREEAQELVKRYGGKVTIAPSRKTSFVVLGNDAGPSKLRKIKELSLKTINEDGLFELIRLMPTNGGDSKEAEKNTIKKNQEMIKIKKEAENMAKEEKRRIEEAEMMRKAKSHGTPITRESVTPSSQLWTTRYAPTSMNQICGNKAAVEKIQSWLKGWPTAHKYGFQRKGQDGLGGYRAIIIHGPPGIGKTTAAHLAAKLTGYDIIESNASDTRSKKLVETGLGDVMDNYSLYGFFAGQNKNVNEQKKKIVLIMDEVDGMSSGDRGGVVALAQMCKKTDIPMILICNDRKLQKMKPFDFVTYDIPFRRPSVDQVRSRIATICHREGLKIPPNVMDALIEGSNKDIRQIINMISAVKLDQSSMDYDQGKAMTKAWEKHIVLKPWDICHKLLSGGLFASSSNATLNDKIELYFNDHEFSYLMIQENYLATKPSSIGDCLGRDAKLKILKITDDAAQSISDGDLVDRMIHGSQQQWSLMPTHAIFSTVRPASFVAGQMAGRSTFTQWLGNNSKMQKLSRYVREIQSHMRLRTSCDKHVIRQQYMPVLWAETIKRLEQEGKECVDEVIDLMDSYYLTKDDFDNIMELGVGPHNSEKINIESQTKATFTRLYNSRTHPLPFMKSSDVIAAAKITKEAPDLEEVFEQEDEKEILVPEQKDDDEIDLKKDKYIKVPKKKSAPAKKVSRKRTKIINDDESDGSEPAKKRKRTKASTGPRKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2U0</accession>
    <name>A0A0B1P2U0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nuclear envelope protein brr6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002703">
        <property type="protein sequence ID" value="KHJ31645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2U0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2U0"/>
    <dbReference type="HOGENOM" id="CLU_040960_0_0_1"/>
    <dbReference type="OMA" id="HPHIPRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="43767" checksum="F38272A38CC299DB" modified="2015-03-04" version="1">MDFEWQTHAPTDPKSPFPLSKPGHKGFESKGVLFSSINQSPTIVSKYRNPSFTTPQKELEHEIFSETSGIESSPGEQGDLEETPDHSKSPQIAPVIINSGTIRQPIFGKYGTDFLGSSPSRTDHRRGKYGKTIVQKMRKRKRIERDFALCQNSESDSDSNIKSKNSKTKNPKVRVETSQPTFLASFFNYIESHPNLPNVLSFYAQLTVNLFIAGLMIFGIFTFWTTVRADVDRASEQERSVALAQIAKCAHDFVLNGCASNSRPPVMEIPCNEFDLCMNRDPDSVGRARISAHTFAQIFNSFIEPISYKAMIFIVLIIIVTIVVNNVAFGLYRSKSHSQHSPFPHLNSQGFQPWFTQMSSQNLGHNVFVDQNYQKTGTNRIDWNIDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W7</accession>
    <name>A0A0B1P2W7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative rna binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003352">
        <property type="protein sequence ID" value="KHJ31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2W7"/>
    <dbReference type="HOGENOM" id="CLU_037639_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="313"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="52524" checksum="6735B28415BC6ADF" modified="2015-03-04" version="1">MGEKTSSRNHQSRKERKAKKRAVENSIPDIPTPELELEPEPVSLATKSAEEVKQLQLDNSLNANEPQGNKRKRNKDGNGESGDNDEEEIDKKKKSKKRNKNLSNKEAKFCEVLKNSVSEATRENINYKNNGEEQRYSPLVKDEGKKKEKKKDSKTKKSNSIIATNNTEEGSSPLLDQEKSSSQKSSKKERKTAKLNVVALKHDHLQNGKNSDDHSGNENMDISKEGLKDSTSTIVTTTTITPPTTTTTSVDEKISKKKKHKKKNSQDPDQSIPKSTSTIIQNTNLPSKRSIKKTSENLVEKVSSSPPRGKSRFIVFVGNLPYTATKDSIMSHFSKLKPLSVRHLTKKEDSSKSRGIAFVEFENFDTHKTALKIMHHSIFDDGKSEPRMINVELTAGGGGNTEDRKTKIKVKNEKLNEERIRRVEEDKAKLKKEEEKKSGLGKESSLKDDQNSSESHIHPSRRRMITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P385</accession>
    <name>A0A0B1P385_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5199</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P385"/>
    <dbReference type="STRING" id="52586.A0A0B1P385"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="MTAFPEP"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="15">
        <location>
            <begin position="45"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="16">
        <location>
            <begin position="308"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="44853" checksum="524C0D92D65D708A" modified="2015-03-04" version="1">MSSAQKRLSQVSEHLAGVKSMITSSMNLSGTTGKAAVLEKHADDIVITACLRTPFTKGGKGGLKDTAASDLLVEALKNLISRSGIDPALVEDIAVGSVLPPGGGATEFRAAALAAGFPVSTSVKSLNRQCSSGLQACVDIANAIKSGMIEIGIGAGVESMSQHYGPGAVSEFSELLQSHPESVNCKVPMGVLSEKMAKDKNISRKAQDEFAASSFQKALHAQNNGLFDDEIAPLKVKWEDPKTGETKDLVVSKDDGIRSGVTVESLSKIRPAFATDGCIHAGNASQVSDGAAAVLFMKRSTAERLNQKIIGKYVAASVIGVAPLLMGTGPWAAIPKVFEKTGLTKDDVDIFEINEAFASQCLWCARELGLDFNKINPQGGAIAFGHPLGCTGARQVSTLLYGLRRNGGRVGVTSMCVGTGMGMAAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3C8</accession>
    <name>A0A0B1P3C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001572">
        <property type="protein sequence ID" value="KHJ33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3C8"/>
    <dbReference type="HOGENOM" id="CLU_004278_0_0_1"/>
    <dbReference type="OMA" id="DIWAGMM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="875" mass="96866" checksum="1C97D063FFBCB9B7" modified="2015-03-04" version="1">MAFILSLWILPASAAFVDFRNCLSERTLHDQPLALQLVPQFVNVIFNSSSPDHNLNITVWVNVTGSTAGSAPRLTLPPANDTNYWNSNNTASGGKIEAIPSPDVINKQTTLYNSINFLNYKQFSEYVPFCDYVENGACPLGPIWSSHNLPMGVPERFPHFGFSYNSYSTYALASIAGLLKVKYGDKEASEIGCISIIITPEISTKLGEVVKFSPALILISVGISILFTAIWSPWGSSDIFRWTTNYGRDPNLLRLITPGFADCLQHIQFVVLTAGLKINYPGFYQPIVSKLAWSILAFNYSFFQNPTRAGSIIDGIYVTHGTFGLEKLSQLIGIAQTENLWNSMAISLLAIIATSLMTIQVGFFIRWTNRKLNDIQEEDLRSKNMPFSIGNIIRIIFNYFLLPLVALSLFQLTIASKSPTYTVGLALFLLLFIVGLAIWLLNVIISTKQKSYLFDDLRTVLLFGSLYCTYSDHATSFVAIPIMLTFVRGVAIGAIQASGITQLVLLAVCEVITILTVHGFRPFQSYTSMNAYHISFSAIRLINLLLMISFDPSLDVNEGSKGWIGYAILLIYSIVLILGFLLNAIQRILEVSARLACVPNEEDQARGGFAEAFCMRQLSRRQYNPTSRQSQLSNVAMLDSNHRSSYSGRVRSQSAGSAGILIGRQSLMTDRTNLDKFVSHQQAFGSHSRSLSTNRDAYTLSHSQTASVPLGLGPSRAPSIGLDTSAPVDPYYRPPRHRKPASESLSTGVKSKLLWDGDKWTDEDSPEYFDTAGEISLKSGRSSPHPEPSQNFGQSKADYTTREVDFYYKIRSSPPNNNISNRRAVTPPINSSETSTSPTGWFRWMISNKTKEKGKGFEVIRNARPPSKAHGPIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J8</accession>
    <name>A0A0B1P3J8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001793">
        <property type="protein sequence ID" value="KHJ32828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J8"/>
    <dbReference type="HOGENOM" id="CLU_1518973_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079699" evidence="2">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="177" mass="18396" checksum="2C317AE572714FB9" modified="2015-03-04" version="1">MKVKCFYLLAILGTALAAPLIEQEVSNLPTHNEFVEKVQTNSLNPSSKHYQNAVISVPKNYQVVEDNGSNNEDDVLEDNENTIKSVINNYNRRYVELSDERSGYSNALEKRQGRGNRDGGGNRNGGGNGGGNGGGNGGGNGGGNGGGNRNGGGNGGGNGGRNGGRNSGDNGDNGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3U3</accession>
    <name>A0A0B1P3U3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002398">
        <property type="protein sequence ID" value="KHJ32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3U3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3U3"/>
    <dbReference type="HOGENOM" id="CLU_030471_1_1_1"/>
    <dbReference type="OMA" id="WLWDARY"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="46071" checksum="CF3E547E9AF829BF" modified="2015-03-04" version="1">MIDLLHILTDALRGTRESPSATCASLLVPLITEFGSERIELRMYHTPNLTGLKKRLIPRRINEGWGLQHMKLYGFDDEIIISGANLSNDYFTNRQDRYHLFSSKDITNYFFLLHSTISKLSFLVLPDSQSRNQYKFEWPASNLAPSPLIFPSLYASESSIALEKLPVPREKDNIVEISDFLDTVVYPIVQLNPLSSHSTEFPALKSILSTLISSCYSKSSWTFTAGYFNPTPELTELLLSTASTSNTVITASPWANGFFSSKGVSGLIPSAYTLLLRRFLQIIQRRNRTRNIAIKEWQYGIVGEPNSWTYHAKGIWISLSGTNEQGKSGVDISVIGSSNYTKRSYSLDLEAGVIILTKNTFLKNQLGKERDALERHTKVVTIDELSSPERKVGFRVRVAMWIVNAVGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P400</accession>
    <name>A0A0B1P400_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001455">
        <property type="protein sequence ID" value="KHJ33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P400"/>
    <dbReference type="STRING" id="52586.A0A0B1P400"/>
    <dbReference type="HOGENOM" id="CLU_021251_2_0_1"/>
    <dbReference type="OMA" id="FKGGSTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="163"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="629" mass="70173" checksum="CBAFFE00AEB1DEE2" modified="2015-03-04" version="1">MVINSSTITQISTHCRPWCLADSHDFIALLFLKRKVDYETRSYSTINHRSFQSQPQQKRQFNQTFNHSSSFIKRNFHNYFLTNLSPTAPHRSDSPSPRSSSSAATAAAANGVHRNKPSDSFSTSSPYKSTGKLSSSTSALSFSVKGSRELIVVRIPLKSAKQHFGVSQSRGTRPSNEDTYQAGIIEIPAFAKGVSINQNLDIKSLDVVDSTSGGPQVFCFGVFDGHGGNECSEFLKNNLYEYIEKTADLFELKCTSQEIKVKSLSNTLFTASEHNLHQKILAYDNKKTEEVSRRLQESCNGNPQVYKQNSVVKDKQEMIINFDTRMEKIFQLEKKLIQQWKDTVGGYFRRFKPQYFSDSSRKSVSIETVLMYSFLKADFDFISAQAHKPESVGNTNSLSPVKKKDTNIQKIGNTERFLGGSTASIVLISTPTPTPFWHPSSPSTMVVAHVGDTRIILCDTATGLAKPCTKNHHPSSPDESNRLRRYATSFVTDSFGEERISGLANTRAFGDIHSKRIGVSAEPDICRIELMAAEYSMLVLVSDGVSGSLNDQEIVDIVKEAKTPEQGAREVVGFATEVSKNGDNATCLVVRLGGWEKRREGGLGSLGTMECREWRRRDASDMRRLERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P418</accession>
    <name>A0A0B1P418_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002682">
        <property type="protein sequence ID" value="KHJ31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P418"/>
    <dbReference type="STRING" id="52586.A0A0B1P418"/>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="225"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="497" mass="55696" checksum="44A6FFE38DA831E3" modified="2015-03-04" version="1">MGTGKKETSRKIRQGKVEDGMSNVKVKGENFYRSAKKVKLLDRLTDGRPQRNAAGKITKSASFQSRQLPNARVEPNRKWFTNSRVIGQDALKSFREAMAERASDPYSVLLKSNKLPMSLINDTKMENGIKTHAAKIAVETSPFGEVFGPKSQRKRVKMSVSSVQDLVDHSSKSYEVYLDRLEQTNLLQGISHPADEIADEDKSDDGCVKSAQESIFNKGKSKRIWNELYKVIDSSDVVIHVLDARDPIGTRCQSVEKYIKEEAPHKHVIFVLNKCDLVPTSIAASWVRYLSKEYPTLAFHASITNSFGKGSLIQLLRQFSSLHSDRKQVSIGFIGYPNTGKSSIINTLRRKKVCTVAPIPGETKVWQYITLMKRIYLIDCPGVVPPNTSDTPQDILLRGVVRVENVEHPEQYIPAVLEKTKPQHIERTYSIRGYQDHLGFLECLARKGGRLLHGGEPDINGVAKMVLNDFIRGKIPWYTSPPLSEDKQSDGSKGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P421</accession>
    <name>A0A0B1P421_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative duf1772 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001662">
        <property type="protein sequence ID" value="KHJ33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P421"/>
    <dbReference type="STRING" id="52586.A0A0B1P421"/>
    <dbReference type="HOGENOM" id="CLU_122611_1_0_1"/>
    <dbReference type="OMA" id="LAWCASD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="17418" checksum="6254282D3D35D453" modified="2015-03-04" version="1">MPDLPTSVRVAQAVGIFGALFSAGSSTGISRFVLPAIRQSPTPILLSQWKGTYNLGSITSPPLALLSSSAMAYVSYYFRSSADGKLWALASAFAISIIPYTFIVVFPTNKFLEEWHSIEGQGVERKDVDDKINEWAYKHSARTCLTLAGGLLALFTVLHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P457</accession>
    <name>A0A0B1P457_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nonribosomal siderophore peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002643">
        <property type="protein sequence ID" value="KHJ31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P457"/>
    <dbReference type="HOGENOM" id="CLU_000092_2_0_1"/>
    <dbReference type="OMA" id="HHIVTEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2134"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3739"/>
            <end position="3815"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="4306"/>
            <end position="4379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="4850" mass="549462" checksum="8706587CA4E9EAD9" modified="2015-03-04" version="1">[encoded data, 4850 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A4</accession>
    <name>A0A0B1P4A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1428983_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="190" mass="20609" checksum="393CF3973AF48DE3" modified="2015-03-04" version="1">MSNSNAPNTLDIDPFEEASSRFTGNASQRGGGADKAFPDAGTAIERLLEEAIEIIESLQKPKTYSKSSHAEKTPTMNKILQEIQSIKATISQSHGLARVQGHSWAKIAGKPEVAGTTIRIQDIEEKREIAKLSSEELVKRIGLKEVVGARHVANGQVKVYFAGEGTKTLLDQQKGWTKKLAGSAXXXXXR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4C5</accession>
    <name>A0A0B1P4C5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4C5"/>
    <dbReference type="HOGENOM" id="CLU_025885_1_3_1"/>
    <dbReference type="OMA" id="DEGCQSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="99"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="443" mass="49778" checksum="23010FCF4C94F7F6" modified="2015-03-04" version="1">MRNTKRNIDNLVIEKKNTKARTSNKPTSTKRNREVKNTDSENEITEDKTARKKRKTSTKEGESLVMPLSCRTDVTSLKKTVFIGAHVSSAGGTQNSVNNALHIGCNAFALFLRSQRKWVSPPLAPQSCEEFKKFCLQHNYDTQKHVLPHGSYLVNLAQAEHEKAEQAYNCFVDDLRRCEALGIKLYNFHPGSSGKNPREESIKRIAAQLNKAHKATKTVVTVLENMAGAGNVIGSKWEDLRDIIELVDDKSRVGVCLDTCHAFAAGHDIRSPEAFKKTMDSFSEIVGMSYLKALHLNDSKAPFASNRDVHANIGTGFIGLRAFHNVINFPQFQDLPMILETPIDKNNSKGISIEDKSIWATEIKLLEGLIDIDPETDGFKTEEKRLQDIGAEERKKFQLQNDKKRQKNLVSMLKNPKNPKKLKKTKKIEVDEESEASDSCCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4K3</accession>
    <name>A0A0B1P4K3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g6070</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="JNVN01002738">
        <property type="protein sequence ID" value="KHJ31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4K3"/>
    <dbReference type="STRING" id="52586.A0A0B1P4K3"/>
    <dbReference type="HOGENOM" id="CLU_033366_0_1_1"/>
    <dbReference type="OMA" id="HFDYELN"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="275" mass="30888" checksum="65442D85DADE7875" modified="2015-03-04" version="1">MAVNDSEGPLATSNLSTYSFPHERLRLVQNEANRIPLVLVACGSFSPITYLHLRMFVLSWDFAKFNTNFEIMGGYISPVSDSYKKAGLVESRHRLQMCQLAVNENPTWLMVDPWEALQSTYVRTAPVLDHFEHEINHKLGGAQKPDGTRVPMKIALLAGADLIQTMTTPGVWSESDLAHILGQYGLFVIERGGTDLENALAGLERWKENIFVVQQLIHNDVSSTKIRLFLKKDMSVQYLIPASVIKYIYENGLYEDSINSPDPLARSLSNKIMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P8</accession>
    <name>A0A0B1P4P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 60s ribosomal protein l7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002489">
        <property type="protein sequence ID" value="KHJ31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P8"/>
    <dbReference type="HOGENOM" id="CLU_055156_0_2_1"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="251" mass="29228" checksum="B3747C577D696849" modified="2015-03-04" version="1">MSTTITSVPVVDQILVPETLLKKRKSQEKSREERAAELEKRKKVQKEKRSVIFKRAEKYVKEYRDQEREKIRLSRIAKQEGNFYIPAENKLVFVVRIKGINKIAPKPRKILQLLRLLQINNGVFVRLTKATLEMLKIVEPWIAYGYPNLKTVRELVYKRGYGKVDKQRIALTDNSIVEKSLGKYGIICIEDLIHEIFTVGPNFKAAANFLWPFKLSNPTGGFRTRKFRHFVEGGDLGNREEKINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4T4</accession>
    <name>A0A0B1P4T4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative c2h2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002180">
        <property type="protein sequence ID" value="KHJ32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4T4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4T4"/>
    <dbReference type="HOGENOM" id="CLU_785723_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058911" evidence="7">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="40683" checksum="2B27F46A7728DF91" modified="2015-03-04" version="1">MPSFGIETAFLPLLAVITVMGALYSRDEVEVNSARSILDLVEYYIFSLDDLTDEHEIRQIMQSGNLEESPFSLSSLQAAYIMVVLQFWTGSAVSKKRTIESRFTNVTRVARRLRLVNSRHDQGDLLSEELWIEKECRIRLINFIYHFDCALTFFAHFPYRLTLTEMNFDLMCEDRLFFSPHPFSEPHFTLGRNLTLLTAFQSLFIKVPPIPGIGTEENPCGLNVSDMFTLIHLLFVYVHNQMTMYIHPFRFIPSESSLGQNPDMNNKSDTNMDILKSALEYWHSIWISIRSNMCSSTIFSENICKNAVNYWMVTQLILMNPKSADTLMTMEIGCDDAISQLRDLPNRIPVHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Y2</accession>
    <name>A0A0B1P4Y2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative solute carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001524">
        <property type="protein sequence ID" value="KHJ33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Y2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Y2"/>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="OMA" id="VRYHWAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="406" mass="45293" checksum="A032FFECA4EB494D" modified="2015-03-04" version="1">MLEQHVDTRNFAVLNEENEQSSRSTNDPSTTTQEEEINSEVVEHGLEALENSKTAWYAYLKTRDFWLVLALGQVLALCITSTNTFSTLLVLHGTSIPTFQTLFNYIALIIIYATYTVYKYGFVKWFRLLVDDGWKYAILSFLDVEGNYFTVLAYRYTNLLSAQLVNFWAIVCVVIISVTFLHVRYKWAQLSGIFICCSGMGILLISDHITGTNGGETSSKMKGDLFGLVGATFYGLSNVFEEWFVSKRPIYEVLGMLGLFGVIINGVTAAIFDRQSFMIAVWNLEIAGYIAGFTISLTSFYSLAPLILRMASAVFFDISLLTGNFWGVIIGLNLFGYTIHYLYPIAFILIIIGLVVYFLSGGVLGESLKPWLGKYQEHGVVGVGTAKMKAIKEAQREGFSASSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P529</accession>
    <name>A0A0B1P529_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002382">
        <property type="protein sequence ID" value="KHJ32051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P529"/>
    <dbReference type="STRING" id="52586.A0A0B1P529"/>
    <dbReference type="HOGENOM" id="CLU_015210_1_1_1"/>
    <dbReference type="OMA" id="IMENARS"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="694" mass="78210" checksum="BE726ED24B2E4D59" modified="2015-03-04" version="1">MAIATNEGSNYDLFSVPENSLVLGQAPVLSTPDFENFNDSSFQHVKSLNFKDKNVKNEEDLCRMYEIQQTAIKILEGQWKRVALQFPDDMLEDAWVVVSNLKKVIGQREIACKETYITKDNNVLKQGQINAPKDEQKKIYEVSWPEEISLETSTLKLENDDMVIGQLTRFKDKSDNILRAKFKDLGDGGLETDFNMSDIKNHKNVKDDEIIITVPKPTFKDLKDGGLETDITNLSISASTTKLNKHYDIEEDEVKFYILADTSYGSCCVDEIAAEHIDAQVIVHYGRSCLSPTTRLPVIYVFTSPLLDLDSIIQSFEEVFNEGDPKVILMADVTCHCHIKSIYMRLEKRGYTNLIAPEIVHNPASVIPNRLISSEINVKEYSLFHLSEPPPALLLTLNSRVKEMYICPMFPTASLHKSVKTTSVNLFRRRYGLLNSLNTCSTFGILINTLSVANHLHALDKIQALIKAAGRKYYTFVVGKVNAAKMANFSEVGGWVVIGCWESSLLDCKEFYRPVITPWELEWVLRSEKVRVWTGEWRGDFIGIGENIEECELNVNDDLTNSKNGREMFNWNGIDQLNSGTSVSSESNSESESEPPQFDLRTGRYVSHSRPMQKSKAKKSQVFSKQSNASEALSQRHKGILATIGGEVSTGAEFLRSNRTWTGLGSDFREDVQTELEIGRTGVARGYMSNGKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5B0</accession>
    <name>A0A0B1P5B0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g0993</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002556">
        <property type="protein sequence ID" value="KHJ31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5B0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5B0"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="AYFERDH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="520"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="595"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="312"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ31819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="737" mass="83277" checksum="8DABD64EFBA08BF4" modified="2015-03-04" version="1">MNENEGEKFEVLEKIGHGSFGVIRKVRRKQDGQVLCRKEISYLKMSQKEKEQLNAEFAILSSLRHPNIVGYFHREHLKSSQDLHLYMEYCGNGDLGKVIRNLILKNEYAEESFVWSIFAQLVTALYRCHYGVDPPEPECNLLGLKNSAKSKPPTGGVMILHRDLKPENVFLGEDNFVKLGDFGLSKIMKSHDFASTYVGTPFYMSPEICAAERYTLKSDIWALGCIIYELCSREPPFNAKTHFQLIQKIKEGKVSPLPNIYSNDLKRVINSCLIVNPDRRPDTAALLKIPAVKLMRKEWEVLKISRTIKIQEELVSKRIQEADDRIRKLEDEKIQMRQEIESSLRREWEVKAQLEINRLVQNEIERLQKKFDQEVKLKVDIEVEKLGSFQSQICSHGKTPLCNFSESSDSSGSNISHSSISTNEDYELTGSTELTEMTTHSPEPMKSPKKITRTPFSRAKTMFVETPMDVEMGEPSPMSIASLSLSPRRTRNRKTKFSRSGLNIFAIAASAETRWQPKIACSDSSDDDEDDVPPVPSPTRARPIQRISRLESEQSKILSKISHNQRKSSGISVPVKTANVPSLANAAPGLHLKTSNNTLRERSNSPSRRLSKIPSSTNLHNHENTSISPLRKNSLKRAGQNDDLNKFVTKSLAIKASNSNIPPRGRTLVELAQARAGGRVINIDANRSPEPKAIRTVLVATADKVAGDWTEPTTWDPEHDEMPSPFLVRSRVLNKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5K0</accession>
    <name>A0A0B1P5K0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative atp-dependent dna helicase pif1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002251">
        <property type="protein sequence ID" value="KHJ32196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P5K0"/>
    <dbReference type="HOGENOM" id="CLU_001324_14_0_1"/>
    <dbReference type="OMA" id="ARHINDY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="6">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication helicase" evidence="5">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="30528" checksum="70F637E860F220D2" modified="2015-03-04" version="1">MRGRIEVPEWIQTTDDRNVFREFMYPLDQVRSGDVSIFQGRAILTSRNDEXSRNDEVTSFNNTIAELRATESYEYYAQDKVQNEEARHINDYPAEFLHTLGGSGLPFGRLTLQVGIPVMLPRNLYPNLGLCNGTRLIITRLFDHGVRGRIISADSNFHVQEHYIHRVVMTTEEDLPFTLSRRQLPLRPCFSMTIYKSQGQTLQRVGVDLSTPLFSHGQLYVALSRVTDVNNLLLLLPRGIRQMTILCIRKYLCDQIIQLSKENGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M6</accession>
    <name>A0A0B1P5M6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EV44_g4749</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="JNVN01001115">
        <property type="protein sequence ID" value="KHJ33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M6"/>
    <dbReference type="SMR" id="A0A0B1P5M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5M6"/>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
    <dbReference type="OMA" id="KDYYVCE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="20">
        <location>
            <begin position="40"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="21">
        <location>
            <begin position="239"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="381"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KHJ33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="462" mass="54150" checksum="E9B43138C7C0174D" modified="2015-03-04" version="1">MPLKSVELPGIKAKGPLQETLRNEVAELLKRKSRGFPGANPVSFSRRHLKELENKDYYVCEKTDGMRYLLYFTEDEAGREIHYFINRKNEFWFIPRGKFHCPTLQDRQGWHTKTIVDGELVIDTLPSGETQPVYLVFDCMVLNGQSLMNRTLDKRLGYFNDRIFDPYKKLFKIYHEEVQYQHFVMKLKVMQFSYGMETMFKHVLPSLPHGNDGLIFTCRTSEYKFGTDHNILKWKPKTENSVDFKIHLQFPIVQPDEIDIAEGFTEAYLDYDALPIFNLHVYISDKTEDKWYGTMHVELEEWNKFKELQEPLEDRIVECSMDDQQRWRYMRFRDDKINANHISTVESVIESIMNPVTEEDLMNASSKIRENWKLRDEEINNAQKKITGQEVRSKSETKTKSPTGNKKKFEEPGPLRSSPRPSPESSPYTTASIGSVSRLKGGTKRKAENQGPRRLIPNSFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S4</accession>
    <name>A0A0B1P5S4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002398">
        <property type="protein sequence ID" value="KHJ32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S4"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="241" mass="26708" checksum="E8698FE6123B6DF6" modified="2015-03-04" version="1">MEIIATRQRREQAWHARLLICTTVISYLDSSLVNFTKEIEKEEVAAFKAYLRQAIANFAAADSPPSPPQVPIHTRPKKGSGKGIDKNLAKKTTVATPQIILSQAVNREMIKEVDPLKIPKASDKTWAVVARKGYKKARIVNNNQTQAVVGNKSPPKPYNKNNSSTSVSDKRLFVRLPQEHEWRKLSPAGIREVAVKKLSISPALIGKIKPVHSGFALSPCSTEARDKISTQEMGSFCQELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5W5</accession>
    <name>A0A0B1P5W5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001861">
        <property type="protein sequence ID" value="KHJ32720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P5W5"/>
    <dbReference type="HOGENOM" id="CLU_001060_9_1_1"/>
    <dbReference type="OMA" id="KPRGCTG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="60"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="418"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="840"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="934"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1314"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1507" mass="168646" checksum="0445F6CB7324DCAA" modified="2015-03-04" version="1">MISVPSSPNRSENESVLVSQGILSKSPENLLEAASNEAISSNIKERQQTKSPDIGSDEIPDVITQIRTINSFIEAESERHIAEGDKAYLLSNKWLSRFKDQDSGLQKFKQPNLEDNVGPINNSDIIKQIIKDVNGNDFVQLKAGLGSPDFTLVPESAWRLLVEWYGIVPGTIPIIRVAHNTNPQGEPNIIFEYYPLVFKIHRLLDATNAKLTSQGSIASSSNAPILIFSRSTKWVKFLEDTKSQTGINISKKVRVWRVPKVPTTNGSIKPVANKSTPPSSRPGSPNGNIDKVPHEPQDSWTKMFLDSSTFLELEIPLARELIDADDVSTDPKYNGSRDLSMVGLGEDQTIVLEELSGNNNTWFSNNISKGIKQSSTVTSQIVASLNTKKYTGFKDSTHSGAMITRGRTQRSGRSPGTVGLSNLGNTCYMNSALQCIRAVEELTKYFLAGAAMEELNNANPLGNNGDVAIAYQKLLEEIYHKENAPCSITPRHFRNTIGRYAPSFSGYGQQDSQEFLGFLLDGLQEDLSRVKKKPYIEKPDSTDDMINNPDAIRQMADKVWDITKKRDDSIIADLFTGMYKSTLVCPECEKVSITFDPFNNLTLQLPIESIWAHNIYYFPLNERPFIMTIEIDKQASIYVLKQYVSVRVGVPVEKLFIAEEFKCRFYKLYRDFETASEIIQNTDHVAVYELDNSPTNWPPPNRLKKKSTSMHDNNELYEVPNWDDPIASCMLVPVIHRRPNTGSSLRTPRRENKKAWVVDCAPHTITLTPAEARSEDVIRRKILEKVATFTTSTAFAENEVDVANNTDTPDLNLSITSESDDRFSNEGKITTLIQEKTDITMGNNSSNVDLPKFQDSTQIQPKTSSDKRESDAPFKSKTARPKWINSSSHLKPEFQNMFEIGYCKGTKEIIPSGWNIIDEDKIYPSISSRLCQPSQTIDGEVIENEDSDSRITSSETSDEDSANFSGASNLNEDSESDDDPIFNNALPVRSAGSKSTVGKVLTKASKNRHGILPRKIKSNNSDVIKSIETDQDEGPLVRLGEMIIVDWNPHSFDAYFSGDGFDNRSQATWDKMPTRKDDVLEEKRKSRLQRKKNGITLDDCLDEFGKEETLSEMDTWYCPRCKEHRRASKKFELWKTPDILIIHLKRFSSCARRRDKLDIRVDFPIEGLDLTSRVISKNEEKKEIYDLIAVDNHWGGLGGGHYTAHARNFHNGEWYEYNDSSVSKQKSLSEMISSSAYLLFYRRRSDVPLGGPKLWQIIEEYDNKISRSEDEVFGTGEDQALVGNSSLHGSSSALTGAGALHHHLLNGSHSTDFAVTTSDYDEPPPYRSHDENDEGSEILPSSNLNRALQESIEDEGFADGSEIPYGKFGMHLNSNNFPGGLIGSGWDFSGLDEDQENINAGSGTGSDDEISSERVQCDSCPSQTSIDDPYKDFEDLRNDDNNSSVDDVLSIADLNEEGNLTTSTMHHNLEIKMMDQVTSFSDPQLITGDIEALGVEELTTDIRLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P654</accession>
    <name>A0A0B1P654_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002100">
        <property type="protein sequence ID" value="KHJ32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P654"/>
    <dbReference type="STRING" id="52586.A0A0B1P654"/>
    <dbReference type="HOGENOM" id="CLU_897704_0_0_1"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34060" checksum="8003A199BC78D92D" modified="2015-03-04" version="1">MAPKPFKPPRPSIAISSSLSSSLNTMKKTAPDQSMDGKHMSEQKKKKMNSSRISSGSGSNTTSLTPGNKKVGNVSAINKRRKIIDKSDRRASSMSTIKLPSLSPSTSDEVESGGKRRSLIDSEAEEGESSDQEDEFMKDLEIDEIMDNDDDDNSENGDDPFGSATEIPKRSRNYSSFRLGDTDGEDEDEILADIDNDVNDDEITSTSIKAQGQSVFIPRDLLSVLLHEMFKSTDDTQEQDREGNGRKIKIAKKGQIRMTKQAVDAVGKYLDTFVKEAIARAACESLERGGIGVLEVEDLERLAPQLILDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6C8</accession>
    <name>A0A0B1P6C8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001745">
        <property type="protein sequence ID" value="KHJ32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6C8"/>
    <dbReference type="SMR" id="A0A0B1P6C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6C8"/>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="482" mass="54619" checksum="0DD3B7E4C6EDE463" modified="2015-03-04" version="1">MVEGDPYTPTWKFTQCFGDKGDVEDITEADIISTVEFDYTGNYLATGDKGGRVVLFERNETKKTCEYRFHTEFQSHEPEFDYLKSLEIEEKINRIKWCKRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSHDLIPGGVPGGGVARSIYNVHFSSPHDLKLPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPHSCNWFMFASSKGTIKLADMRESALCDHHAKQFEQEEDPTSRSFFSEIISSISDVRFSHDGRYILSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDGRNVMTGSYNNNFMIYPSDPLKEVEVVLQADKSAFKAKKVGVPTPINLSTSPTATNGGKKSNSRTGSPGGVTGQGGRMKKETDADQIDFHKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6S1</accession>
    <name>A0A0B1P6S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative myosin class v myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001130">
        <property type="protein sequence ID" value="KHJ33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0B1P6S1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6S1"/>
    <dbReference type="HOGENOM" id="CLU_000192_3_1_1"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="74"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1232"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1577" mass="179623" checksum="7A84F9F1463424BD" modified="2015-03-04" version="1">MAQPYDVGTKAWQPDPTTGWVASEVTSRRIEGDKVFLDFTLENGATKTIETTAEALAQANNPNLPPLMNPAMLEASDDLTNLSHLNEPAVLQAIRLRYLQKEIYTYSGIVLIATNPFARLDSIYVPGMVQVYAGKQRAVQAPHLFAIAEEAFADMLRSGKNQTVVVSGESGAGKTVSAKYIMRYFATREPPDGPGTRTKRGSDSMSETEEQILATNPIMESFGNAKTTRNDNSSRFGKYIEIMFDNQTTIIGARIRTYLLERSRLVFQPFKERNYHVFYQMLAGASESERQEWSLLPVDDFNYLNQGSSPSIDGVDDKAEFEALKKSLATIGVKQDQLTEIFKILAALLHLGNVKITATRNESSLTPNEPSLEIAASILGIDPVEFARWTVKKQLITRGDKVVSSLSQQQAIVVRDSVAKFVYSSLFDWLVENINYALAAEEVLSRVKSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNAHVFKLEQEEYVKEQIDWTFIDFSDNQPCIDLIEGKLGILSLLDEESRLINGNDKNFVKKLDENYGGDKHKFYRKPRFGELSFTVCHYAIDVTYESDGFLDKNRDTVPDEHMAVLKASTNKFLGQVLEAASAVREKDSASATTSSAVKPAGGRRIGVAINRKPTLGGIFKSSLIELMHTINNTDVHYIRCIKPNERKESWVFEGPMVLSQLRACGVLETVRISCAGYPTRWTYEEFALRYYMLIHSSEWTSEIREMANKILVKALGTSNVKGLDKYQLGLTKIFFRAGMLAFLENLRTSRLNDCAIIIQKNLKGRYYRNRYLAARASILKFQSSSRAFFARNNARETRSIRAATIIQRIWRGHKQKKYFNAIRSNVILAQAVFRGYLRRRQITDTRRNNAAIVIQRAWRARKQMLSWKQYRRKVVIIQSLWRGRQARKAYKIIREEARDLKQISYKLENKVVELTQSVGSMKRENKALVTQVENYENQIKSWKLRHNALETRTKELQSEANQAGISAARLAVMEEDMKKLQISFDESAANIKRLQEEERELRELLKKSNAQLEETQRMSSAHETEKLTLRQQLAELQDQLELARRGAPLVSNNGDSANGTNAQQPLTGIFNLVTSKKAKRRSANLESRDIDRLSDTYNPRPVSMAVTGSNIHRQAIGSLEFSPDLDNIEMELENLLSDEEGLNEEVTVGLIQNLKIPSPTSNPAPTDKEVLFPSYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGDEAINPGAFWLSNVHEMLSFVFLAEDWYENQKTNNFEYDRLLEIVKHDLESLEFNIYHTWMKVLKKKLHKMIIPAIIESQSLPGFVTNETNRFLGKLLQTNSSPAFSMDNLLSLLNSVFKAMKAYYLEDSIITQTITELLRLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVTEKSDVLLLPAVDMDDSGPYEIAEPRVITALETYTPSWLQTPRLKRLAEIVSAQAIAQQEKFENTLDEDLTDSELNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P713</accession>
    <name>A0A0B1P713_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">EV44_g0306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01002075">
        <property type="protein sequence ID" value="KHJ32454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P713"/>
    <dbReference type="STRING" id="52586.A0A0B1P713"/>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="29841" checksum="0DADBFDC8C64F0C2" modified="2015-03-04" version="1">MQRLGVCVIIIILIANKNQPKMQSSSNDDVIDYSLFVREDLTPIPSYKTASTISHHFTNLLTTPIQLHEDLKSGCGGQLWPAGMVLAKHMLRYHKNSLTEARILELGAGVGLVGLSVAMGCQINKPIYITDQENMMDLMRKNIKINGLESMAQELVLEWGNPLPDEVLKRQPNLILAADCVYFEPSFPLLLTTLKDLSNLSSDTIIYFCFKKRRKADIRFLKAARKIFIVEEPEDEDRVQFSRQGLYLFTFKLKHWNILTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B5</accession>
    <name>A0A0B1P7B5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative fha domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001011">
        <property type="protein sequence ID" value="KHJ34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7B5"/>
    <dbReference type="HOGENOM" id="CLU_021864_0_0_1"/>
    <dbReference type="OMA" id="VEHAGFM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="192"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="752" mass="83354" checksum="49B2BC57591C2C81" modified="2015-03-04" version="1">MTAVANLPSLQQNNRPRWDISNGQVTCDPINADKVARRYASKKIVQRPKTLPVIASLGSVPHPVDTAQTKNHVNGAVMSAPAVDNGTWATGGAKKKAQKPEAWLNRRSNSVSNFSTSSTRSSDEFAPNELISRCSGTTTSAQRSSNISSQKPNGKRSQNQLLVSNPPVLCLISMNGTFDRKKISVPFYPESVRIGRQTNTKTTPSPTNGYFDSKVLSRQHAELWADKNGIIWIKDIKSSNGTFVNGARLSLENRESEPHELEKHDQLDLGIDIVSEDQKTVVHHKVAAKVEYAGFAETLDGIDFDDVDNVTSTNIGLSQSQVQIRGKNELHNPVGNNKKQGTTTSITNNLISLGQQQQMKFWMVPVTVEQIVKRLTNEMRNARLQTNELEKTHEFLGSLLDMNIIGQSDRPIVNEAIKPSAFLNNMTRSEPTNCFSAPPAPPPQQPLPEKPDFARYNDYQSQASHIKQANIEPSTSVSGISQARTGTLGQVMSLMEALSVSKKEIESQNLKVRDLEELLIKEKKAREQAEEIAKQLELESETRRNGLLTVSLNQSEKENEFQPYTQFPKQISHIKTEASSLSPSTKTEVHNSESSDSMDTCLETIFAEIGELNENFATCNVHTEAATVNRNVDQKTLAEMVEEIRHDHAKRNKLSLDELGFSDNCSGESILLNKNRTDINMNQQGLKQTFKAQSPSNNEVLSTTGNLVKNNNYSEPLLTHYTAPFASMLGIVLIGVGIMSYLNGWHVIKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7E4</accession>
    <name>A0A0B1P7E4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative signal recognition particle protein sec65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001549">
        <property type="protein sequence ID" value="KHJ33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7E4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7E4"/>
    <dbReference type="HOGENOM" id="CLU_065433_0_0_1"/>
    <dbReference type="OMA" id="NPFKEAM"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="273" mass="30126" checksum="BFAEE57E824BA8D8" modified="2015-03-04" version="1">MSKTRIEEVSESDPSEGDISDLSDDDFNERDILKTRRPPISQRPITESISNPSARFKTTEDSSKYSNFQCIYPIYFDKLRSRRQGRMVGKELAVENPMAREIVNACGRQGLETVFEPTKFHPKDWANPGRVRVNLRGGRNLSVKNKHHLYILISEHLKANPTTVTSVKNMIVPGVPPPNPSKDYPTPAIPQGWKINSILPYYSPALSDGGASEEMFKQMVSQMQSAGGSMPGGNVGGIPNMAALQGLMGGAATNNIGASRPQEKKKKKSLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Q2</accession>
    <name>A0A0B1P7Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000739">
        <property type="protein sequence ID" value="KHJ34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Q2"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="OMA" id="SMNECKA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20755" checksum="F124D9F9FEC42AAB" modified="2015-03-04" version="1">MVRVHGKTRVGAPHRSWLAHFPRDQAPRPGFRLFDKSGVAVLYKLRRSIQQCKRYHGFHATRGCSRAPACENCSSTMYSMNECKAPTNCRNCGGPHRSDSRNYLARPSRSGPASKDQLKTIRQMGQREYHAKARAEAAVIRAEVATTSVERLQSTDQSNVQAIIPTNEMAMSEAPTEGDIIPETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7V6</accession>
    <name>A0A0B1P7V6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g1449</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001846">
        <property type="protein sequence ID" value="KHJ32739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7V6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7V6"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="205"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ32739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="537" mass="60169" checksum="0DFAB7028A88D675" modified="2015-03-04" version="1">MDSSLHETYDTILTLDFGSQYSHLITRRLRELHIYSEFYPCTQSFSDLRWKPKGIILSGGPYSVYDAEAPHVDPSIFELGIPILGICYGLQEIAWHHGKNVIAGAEREYGLADVETLKSDSNSEALFEDLEDNIRVWMSHGDKLGALPHSFRTILTTKNSPFAGIAHETKHIYGIQFHPEVTHTPKGSQLLKNFAVKICGAKQNWTMDSFINKEKDRIRSMVEEEALVLGAVSGGVDSTVAAKLMFDAIGDRFHAILVDNGCMRQNECAQVKEILVKELGINLTVVDASDLFLDGLKGIYDDPEAKRKFIGNTFIDVFEAEALKIEASAKTHENKSKVEWFLQGTLYPDVIESVSFKGPSATIKTHHNVGGLPERMVKGQGLKLIEPLRELFKDEVRELGRQMGISEELLMRHPFPGPGIAIRVLGEVTREQVAIARKADFIFIDEIKKAGLYNEISQAYAALLPVKAVGVMGDMRVHQQVITLRAVQTTDFMTANIYRFDWEFLEKVSTRICNEVDGVCRVVYDMTSKPPGTIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P857</accession>
    <name>A0A0B1P857_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000634">
        <property type="protein sequence ID" value="KHJ34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P857"/>
    <dbReference type="STRING" id="52586.A0A0B1P857"/>
    <dbReference type="HOGENOM" id="CLU_015328_0_0_1"/>
    <dbReference type="OMA" id="PEEMHPS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="606" mass="67386" checksum="4DEDE19FCFDD4366" modified="2015-03-04" version="1">MVPRRRSTRLRNATPLKLPAQKVAQLESVTESHSTSEVDLLESNQNISLVPKTPVTTSRIRPAPEEMHPSKVHQSTTQEPDSGLRLGFTDIKTEGSGQPSGITQKSPSKINIARSSFDFRFARPGLHLGPEAQRIMDELNEEALRIKAKLAAEREEKKRMATCDEQKTTQRQTKPKCEVGRFSDAHKAEFKKMDSIAGHPSAFRAQLSRAVPVKNNLKRSSSKAQLDTNYADEKVHKSGRDKVNLYAGDRHQDNQPMKIARKQITDDISSASRKHHLPFTLDILSSQSKIPSATVTPTQASLSRSRFTNPTPRGPTSWKSPQKNKTPKPLHLEAKNTINCDPCKPDRLKCSLTSSKVTTEPVAFLNITNRKCKNDLQKVFSSISNPDSGIGNSNKLNFTPKTIDKHAVAAQNSPSPIRSFVISSNSKINLSAKSLNVGNINAPKLSQKVEYPSLSDLQSPHHNLSQDRQPSSIPGTFTFRSDQSIKFLASPNKSGSSLVKNRNPQAPENKASELMADNFLANDKENKTPNLLISPEISNKRRKRLDSDDGQTERFSKKPKKQDTKSTIPRLKGLQGSVQKMRNPQKKPGVLSLSRLNMLSRPKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8B6</accession>
    <name>A0A0B1P8B6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="JNVN01001586">
        <property type="protein sequence ID" value="KHJ33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8B6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8B6"/>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="OMA" id="MGDAWGH"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="165"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="36460" checksum="96CFA32D3EC271EF" modified="2015-03-04" version="1">MATMATNPNSYKLNHTMIRVKDPNKSIKFYEFLGMKLVRKYEQPEARFDLYFMGFDSIKHSSDREGLIELTHNYGTETDDDYVVSTGNDNPFLGFGHTCISVDNIQAACDRIEKAGYSFQKKLNDGSMKNIAFVTDPDGYWVEIIGQRNVDLTQHVPNTDIGTYRMNHTNIRVKNYEASLKFYQEILGMKLIGSLELKQENFNLYFLGYSNENITITDKDLTSLASREGILELTWAYGTEQNAEFKYHNGNDKPQGFGHICISVDNLENACQRFENLNVKWKKRLVEGRMKNIAFLLDPDGYWIEVIQNESLVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8I5</accession>
    <name>A0A0B1P8I5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ubiquitin fusion degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000816">
        <property type="protein sequence ID" value="KHJ34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8I5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8I5"/>
    <dbReference type="HOGENOM" id="CLU_012913_0_0_1"/>
    <dbReference type="OMA" id="THLKHHE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="3">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="160"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="5">
        <location>
            <begin position="262"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="4">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="741" mass="85018" checksum="E33D0E777F100E39" modified="2015-03-04" version="1">MEVPNISINWSGDFNVTQNFRIKLSGDKIILPKSALEQLLAASSSVTSTSTQYEANFDSYNQFSDINSQTSKLTDKNQQLPQPLTFLLVNPKNGKKVYAGIQEFSAEEGEIALSPFLFEALNISDHSNQSNHMHGYQTNDESNTDDEIPRIKVLAKQLPKGKFLRLRPLEAGYNPADWKSLLEKYLRENFTTLTRGETITVQAPRSEVFRFLIDEVSPNGDGICVVDTDLEVDIEALNEEQARETLKQIFAKSFKPGNKNGVSAASELDMWKQIKGKVIEGEYVDYTLLSWDRSQGIVVEVIGRNVELFVSPFSSRQRVPPREDEHFWGNFDTDLKKEIIIEPPAEEMKMIEHFLISLHARGQSHTPHEYSIQVRPRSLTKTENCIKNSENENEIHDENEVQCKTCFKWLPKTNIFLHENFCSRNNEVCSLCNNVFQKNSQEWRDHWHCEHDKVFGHTAESKNNHNNIFHSSRSCPNCSYTAKNLIDLANHRTTLCPGKIILCQFCHLEVPQEGDPLYPSPEALIYNLTAHELSDGARTTQCHLCSKIIRLRDLSNHMKYHKLENSRKEQPKICRNVYCCRTLDSLEKDGKIKECKQLGETPKNKLGLCNICFGPFYVNMYDPEGKALRRRIERRYLSQLISGCGKSWCRNQYCKTAQNLKLTAKTALPLVKPLIEPDGMKKMYFCVDQENNSSKIMAEILAEEKKFSLEWCVAALELRRNIDSAQIWLDNWAPKLEKGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8X6</accession>
    <name>A0A0B1P8X6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alpha and gamma adaptin binding protein p34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001612">
        <property type="protein sequence ID" value="KHJ33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8X6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8X6"/>
    <dbReference type="HOGENOM" id="CLU_031716_1_0_1"/>
    <dbReference type="OMA" id="EALMMRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="32854" checksum="D227AC8DC22E1F2B" modified="2015-03-04" version="1">MEISNPRRILAVGQTNSGLLDLVQGLTGSIPTPNNGLVAGTTHNWVVETNYYKTIIPIWLDEITSPSLWSTEFLAPEAREVLNSLGALIVCFKKPVEKADFKEVENLLKSVGQVVKQGSGLVWGGVCLAVAMPQTVIPHLEKSYEDWEDLCQEFGFEFIDFEMKGRNQYSELMGLDRLKEALQSNDWENNYELGDYDNDIEELDEFDVGDFSGFKIEAAQVGKEMQEMRIGICQNQGSTEMKSEASSNYEEEVEKLEAIVSKINLIRDSTADLPNAEKKRMVAKLVSEVLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P955</accession>
    <name>A0A0B1P955_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001578">
        <property type="protein sequence ID" value="KHJ33194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P955"/>
    <dbReference type="STRING" id="52586.A0A0B1P955"/>
    <dbReference type="HOGENOM" id="CLU_033074_1_1_1"/>
    <dbReference type="OMA" id="EPLAHIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="397" mass="45143" checksum="769E8867F978917F" modified="2015-03-04" version="1">MTQFVRCKYKAKSNSSSRTISHQSYGSYLSKRIAPSTQEYMQTQNSVHAEDCNSSLSTLDVTHSPTETYVDSNENIDVVGDESPVYCIYPSFQELKSRVITTELRATNSTNFAEHFPSSRILSICHDVLSSDNHMNLRVDTEDINHRGMVQLFHLRLQDVQMRQSSLRRYERNSGREICKTSRKLVPATPMFPRSVSTALAHIKLPSSPSNLLQKFWPDTSSHWGISTKCPQYSINSSSNHIESNIIRLEFSNYAQVEIKCRSGRRLGKRYEFEYWGNNYAWKRVGKREAKYKGVSYHLHRAGHASAVAYIVPELQNQWQQYQERKAGNWVPPCGMWIAEAALTEGNDVADVIIATGLMALVDDNIAGYLDDSSSLSRPLFGRPIYEPLVPLLKQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D0</accession>
    <name>A0A0B1P9D0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001130">
        <property type="protein sequence ID" value="KHJ33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9D0"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080553" description="Probable aspartic-type endopeptidase OPSB" evidence="13">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="67"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="470" mass="50108" checksum="B579F9AFC1CD8097" modified="2015-03-04" version="1">MRGSKLYMLAAFLTISEGINLRPSTENPQVVQFPIERKRNTLNPVVRDRLRKRGVVKGDLDNKDTLYLFNITLGTPPQTLRLHLDTGSSDLWVNTPKSTLCSSKLDPCSSTGMYDANTSSTYDFIASNFNISYVDGSGAEGDYVTDVLTLGGKSIDKFQFGIGYESSSPQGILGIGYAVNEVQVGRAGKKPYLNLPLRMVSDGLIKSTAYSLWLNDLDASTGNILFGGVDTAQFVGNLQTLPVQKIGGVHSEFLITMTGLSIGRNVLATDLGQAVLLDSGSSLSYLPDALTGSIYSLIGAKYSEDEGAAYVPCAYAQSSVTIDFEFSGPVIKVDMSELVIPVSSVSNQGSLAFSDGTPACLFGIAPAGGGSSVLGDTFIRSAYLVYDLDNNEISIAQTNFNATENNIVEIGTGRKAVPNAKPVPNSAPATSGTELNNSKENSSIRIGSLMQSPSFLVILALFYCIFFIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9V8</accession>
    <name>A0A0B1P9V8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative splicing factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001429">
        <property type="protein sequence ID" value="KHJ33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9V8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9V8"/>
    <dbReference type="HOGENOM" id="CLU_069491_1_0_1"/>
    <dbReference type="OMA" id="CMAVWSQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="97"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="289" mass="31922" checksum="570D84B0184CEF56" modified="2015-03-04" version="1">MSNQIATLENEIKEYKVQLETVQLGLQADPENSELQELKTELEQVISLTEATIAELKPVSVPTAVSKKQAPAKEKWSRENHPAFKKSTTAVDEEVPSSFKVNDTVLAKWHSGDKGFYPARITSITGSSTAPVYIVKFRSYNATETLRAKDIKPIINPNKRKADGTPVVPPNISSQSLPSNVISAAADINPELAQQTRREPSKVSDGPVRPPKVPKKFKANKELEAGKSKWQEFATKGKFGKTAKKESMFRTPEGVHGRVGFTGSGQSMRKDQTRTRHIYNMNGEDEGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W7</accession>
    <name>A0A0B1P9W7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001427">
        <property type="protein sequence ID" value="KHJ33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9W7"/>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="OMA" id="MQQTEAD"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="26513" checksum="B3ECD33239202440" modified="2015-03-04" version="1">MGRELQKKKRRSSNPKIRLKPKSKKLKILGNSIIAANWDHKKTLSQNYRNLGLTSRLNSTTGGVEKLISGTQSNSSTLSKFQISNTILKGIEPGEARVERDPLSGKILRVIHQKSKSNPLNDLISSESEEETICKDKNFSDHSNYINTENNIIRQLEEQASRVPEKKQRKLSEREQIWIENLVTQYGDEYEKMARDSKLNPMQQTSADIRRRIEKWKASRSCTSSNDKEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9X4</accession>
    <name>A0A0B1P9X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mitochondrial protein fmp25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000555">
        <property type="protein sequence ID" value="KHJ35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9X4"/>
    <dbReference type="HOGENOM" id="CLU_021989_1_0_1"/>
    <dbReference type="OMA" id="YDQPHEI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000027">
        <property type="entry name" value="Protein FMP25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="589" mass="65341" checksum="FDF0450DDEE5533D" modified="2015-03-04" version="1">MTHARIITRAVASNSRSPGLAWKPYYTFTQNRYTHHKSKLSISATDRLLKNVRLTGFLLAIAFGGGFVLYNPGLTSILHAETIPAPAEIQFEQPRKKSTSPEENRELVSSQHLQVKRSWENPGVYAWGNNAGRVIENSNETYIKTPKRIPYFDGKLLRDIKLDKNFGAAITEQGDLLQWGTGFCPSYEGPRPTLKGKNLVKLSISKDRILGLSSSGKVYSVPANQSDQELEPDSDGTNWLGFWGSSGAGYRRLDPKNLRWGEKIKDISSGLEHCLMLTSKGRLYSVASASRDFPSKGQLGIPGLTLQTKSPGRFDEPYEIDSLKGFEISKIATGDYHSLVLDNKGRVFTFGDNSVGQLGSEPTIESPTIDFPSLFSIEKLYNGTKLLPKITGIAAGGNNSFFTVEATRIAGQSEEEPRNLGKITADTWSCGQGILGSLGNGRWTHVQGIPTKIKALSGLFEYDEKNKVIIPIRLARISVGQTHVSAVMDNVTQLDVDNKNSENETNWGADVLWWGGNEHYQLGTGRRNNVSQPVYIQPLDMKAEREKGRLDKHRFHITPRKEIRLHSRKVSVEQKIECGRDVTAVYSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAA7</accession>
    <name>A0A0B1PAA7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g5239</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001337">
        <property type="protein sequence ID" value="KHJ33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAA7"/>
    <dbReference type="HOGENOM" id="CLU_000315_24_2_1"/>
    <dbReference type="OMA" id="HINEGGL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="SNF2_N"/>
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        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAH_ATP_HELICASE"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="19">
        <location>
            <begin position="283"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="745"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1284"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="165"/>
            <end position="184"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1579"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
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            <begin position="450"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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            <begin position="1579"/>
            <end position="1590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00009220"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00011826"/>
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            <dbReference type="ARBA" id="ARBA00012551"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1598" mass="184012" checksum="FA39AFE13EBB97F8" modified="2015-03-04" version="1">MKEKVTILAPERSLDDAQYNEGQPSKKRRIERKKPESPPWKKNIADGPSTFTQEGRRRSGRVNSIPKELQPPCEKRSTRASHKLKSTRIKGYGQEVKNTLSYPLKPSKDVLTPINVSQKPVSYTPRPKTSTSYTPPKSFNRKSSQIKVTKNSTYLHSELLGSKASASPHKISQSKKITKLGKDIDPSPGINARIKLRVKPPKLPITHPGLVLNRQSRHQNLRDYLRNEGQKHINEGGLSHSETPTEYPPNSALVDARTILHAERAVEPGGILAYRKYHIINEIEDSQKFPLQFSHRDHLCRAVSSFRKLMLIEQRNHRQLAKRIAEACAEEWLRRQPKTIEQVEAELIINSQIRYKSVMRTLQGTWENVMAEVNRRRLLEWELQEQARVHKALSEAVEKSQQKLQQHKACMNMNVLINEKEEVESHVDSDDDIKMNLDFSNSESNMSQESSDEDENKFSIDTEEDDLLTTDQLREKYATISCLSNGYLDDKITHPEDNAKVESECDLNEASEIKSFGNENDESTDMNTDDCISINDSYDISTDNEDEAGETSLLGFFTKTELKALELGKVKPLDDLKPNEMIESNKQDNSFKVNDRVDEALTKITPENAQVEDGSLRNFSKITSEKTKNDNYSLINDESLKKDTASLFSDDKVKYSIMESPIPLDYTSPSIPSHTSDSKICQRSTRTENCLFQRELSLSLESKSSSPKHGQLTTPQANDENKTSVPFLLRGTLRKYQHYGLDWLAGLYANNTNGILADEMGLGKTIQTIALLAHLACVHEEWGPHLVIVPTSVILNWEMEFKKWCPGFKIMTYYGSIEERKKKRIGWKNKDMWNVCITSYQLIIRDQQVFKRRPWHYMILDEAHNIKNFNSQRWQTMLTFNTRARLLLTGTPLQNNLTELWSLLYFLMPSDGKNQGVGGFADLQEFQDWFKKPSEQILEHGREQMDNESWGIISKLHKILRPYILRRLKVDVEKQMPAKFEHIEFCRLSKRQRELYDGFLNRDDTKETLAFGNNFSIINCLMQLRKVCNHPDLFIDRPILTSFPMKKSVVADFEIKELLVRRRLLREDPMSQVSLEFLNFVPTKYERSSDYVASRTAVLSAQRKFMDLREIQRLRAQKTSIKYDPSTVKSNLAYLESSSNWGRFEELQHCVYLNALRRQQRPIYGSQLVKLLTFGLNEFNPKPKKRDQLIEWLENTSPVMRDLIKSVSDQAEANKSNIQRFACSTPAVIAKDITMFTLTSQGLAIIQDHIDISKVDPFHEARMRLSIQFPDKRLLQYDCGKLQTLDRLLRKLQTGGHRALIFTQMTKVLDILEQFLNMHGHKYLRLDGSTKIEQRQILTDRFNNDTRILAFILSSRSGGLGINLTGADTVIFYDLDWNPAMDKQCQDRCHRIGQTRDVHIYRLVSEHTIEINILRKANQKRMLDDVVIQKGDFTTDYYKKMTVKDMIENEPLLTTTDEVAKAAVDRVLGVSGSKEIHHGFDQAEDKEDVIAARLAEREIVQTDAQDFDENLPTLSENTGPDTTVTSLQEMSSDLKNPPVDGDQIELNAWGEPIQPMDNYMLTFMTEQLRDTSLEIPKDKIKNKRIKESRSQKNKNVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAI2</accession>
    <name>A0A0B1PAI2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000944">
        <property type="protein sequence ID" value="KHJ34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAI2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAI2"/>
    <dbReference type="HOGENOM" id="CLU_005230_0_2_1"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="864" mass="98856" checksum="0CD156BB2DA7C9A3" modified="2015-03-04" version="1">MAKQNTMFRSADMSLIQLYIANEIGRETINALGEISQVQFRDLNSTVSAFQRTFTQEIRRLDNVERQLRNFHTQIVNSGIPIRKVDLETENFDVPTASEIDALTDRCQSLEKRINSLNDSYETLKKREIELIEWRCVLREAGGFFDRAYGNVDEIRESNDNDDAPLLQDLEQNEQGITTNEDAERSFSIMNIRFVAGVVPRHRVAAFERILWRTLRGNLYMNQAEIPEPLIDPSNNKVTQKNVFVIFAHGQEIIAKIRKISESLGADLYNVDENSELRREQVLEVNAQISDLASVLGNTEKTLRAELNQLSQSLASWMIVIKKEKAVYQTLNMFSYDHARKTLIAEAWCPTNSLPLIKATLQDVNSRAGLLVPSIVNEIRTNKTPPTYQKTNKFTEGFQTIINAYGTAKYQEVNPGLPTIITFPFLFAVMFGDMGHGFIMFCAATAMIYWEKPLKKVRDELFSMAYYGRYIMLMMGIFSMYTGLIYNDIFSKSLTIFPSAWEWDVPKGWQEGQTLEAKLKGDYRFPFGLDWMWHGTENDLLFANSFKMKLSILMGWFHMTYSLCLSYINARHFKSPIDVWGVFVPGMIFFQAIFGYLVFTIIFKWCIDWYAIGQSPPGLLNMLIYMFLSPGTVDEPLYGGQAGVQIFLVLIAVVQVPILLFLKPFYLRWENNRARSKGYRGISEFSRVSALEDDDENDSATLDGRNSLASDGEEVSLIRQGNNNNDDDDEHEEFEFGEVMIHQIIHTIEFCLNCVSHTASYLRLWALSLAHQQLSVVLWNMTLAIGLGSTGTIGVFILVVTFFVWFFLSIAVLVVMEGTSAMLHSLRLHWVEAMSKHFMGDGTPFEALSFKQMLEEDETVVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAM9</accession>
    <name>A0A0B1PAM9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitochondrial atpase complex subunit atp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001091">
        <property type="protein sequence ID" value="KHJ34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAM9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAM9"/>
    <dbReference type="HOGENOM" id="CLU_047290_1_0_1"/>
    <dbReference type="OMA" id="YFPNFHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="37546" checksum="B7308A6C4ADA8359" modified="2015-03-04" version="1">MIRQRWPLPLTRNWIWSTSCLRNTRQFSHKSSFRNSSHESKRDTNQDDLVSPSDVLKSAPRSYGKDISEYIPKPLDRPIGLSKPPNPGENTGIDVRTWKERRDDLVDYDKHLIRRRQLTSKLATPYFREWKNMRFSKGKSFLAPSRLFRSDKALYFPNFFGQTLHLDKKMRDTTPILRHKISILSVYSSAWGEKQAASFVSIEEHPELHELLNSKKEIVQSVNINFEENAIKALLIRMFMRGLRKKMGKENWGKYFLVQRGLTIEIREMIGLLNSKVGYTYLLDNQCRIRWAGSGFSEENERKSLLKGVKKLIEEQLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAN1</accession>
    <name>A0A0B1PAN1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EV44_g2756</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAN1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAN1"/>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KHJ33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="779" mass="88919" checksum="2F9A47CC46698B66" modified="2015-03-04" version="1">MKFNIDSSGLILLETLDAGGHCVLEMPSGTGKTVSLLSLIVAYQQYYPEHRKLIYCSRTMSEIEKALAELRALMKYRAEQLGYEEEFRGLGLTSRKNLCLHPTVKREKSGAIVDAKCRSLTARFVKEKKERGENVPICIYHDNLDLKEPHNLVDPGVYTLESLMRYCEQEKICPYFASRRMMSFCNVIIYSYHYLLDPKIAERVSKELSKDCIVVFDEAHNIDNVCIESLSTDITNDSLRKATRGAQNLEMKISEMKEKDKEKLVNEYAKLVEGLKDASEAQAEDAFMSNPALPDDLLTEAVPGNIRRAEHFVAFLKRFIEYLKTRMKVRQVISETPPSFLAHLKEYTFIEKKPLRFCAERLSSLVRTLELANIEDYQPLQEVATFATLVATYEKGFLLILEPYESDTAEVPNPVLHFTCLDAAIAIKPVFDRFSSVIITSGTISPLEMYPKILGFSTVVQESYSMTLARRSFLPMIVTRGSDQVAISSGFQVRNEPSVVRNYGHLLTEFSKLTPDGMVVFFPSYLYMESIISMWQGMGILDEVWKYKLILVETPDAQETSLALETYRTACCNGRGAILLCVARGKVSEGIDFDHQYGRTVLCIGVPFQYTESRILKARLEFLRETYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFLRKRNQLPRWINQALLDSEVNLSTDMAFGIAKKFLRNMAQPFRSSDQEGISTWSLEDLERFKEKEEEEAIKKLMTADGGSKEESLPQKELLTANITDILDDDELEVCMMDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAQ3</accession>
    <name>A0A0B1PAQ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative g2 m phase checkpoint control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001259">
        <property type="protein sequence ID" value="KHJ33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAQ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAQ3"/>
    <dbReference type="HOGENOM" id="CLU_019221_4_0_1"/>
    <dbReference type="OMA" id="WYPPPGH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="557" mass="60492" checksum="64FAECDFF3AD64BF" modified="2015-03-04" version="1">MTEFIGARISLVSKSDIRYVGTLHEINSETSTVALENVTMLGTEGRRPDNEVAALDSIYEYILFRGTDVKDLRIEEAPIEKKNKAPQIPNDPAILGSGSRPTPKIRSPYQQQISSTQIHGQHIISPTHSTSVSQQTEPLYIQQPQNPQFYPQQADWCRNVSQAPVGYNAVPYTGPPAWNHGPQNNFPTKSQFSPYGYSTESSNMIAQQPGTSSNKSIAIGVASNKRDTAPTRKPKKTSGSKGLLKAAEMPAAPVQKIATPPVTAKLSTIDAKSDVPLPVSIQKPSHTPNSLKSVPIGPKTVNRVQPALPLRNIPVNNEPLQSSSGNMNFQRPIEPSVNLREATQAASAAVSAAMAKLPLTSVHGNPDDNKGHKNPIKNYRKSSKSNASACAERTSRGNHKANGPRNEPHGATPKVEVPPEDFDFQSANAKFNKEDLIKEAISAAPITKSGPGKSPVENETPATYNKATSFFDNISSEVKDREEAGNTRPGGRKWRGEEQKKNLETFGEESIDNNHRGGYRGRGRGRGGYRGRGYSRNIHSSRGRADHQNRGNAQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAQ4</accession>
    <name>A0A0B1PAQ4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000444">
        <property type="protein sequence ID" value="KHJ35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAQ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAQ4"/>
    <dbReference type="HOGENOM" id="CLU_019618_1_0_1"/>
    <dbReference type="OMA" id="KLITHQY"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="23"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="526" mass="59796" checksum="0491B41CAA28FFF8" modified="2015-03-04" version="1">MKENPDREKEISCQGPSEREKKYDRQLRLWAADGQKALEQADILLINSGPGVVGVETLKNLVLPGIGKFTIIDSNQVSEADLGSNFFLDENCLGKSRAECCVRFLKELNEDTQGEYHSTLDVPYLESLFTRRYFSFVLCTFPIQVEVLSVIKNYTHNFKIPLILIHSVGFYSYFKSILPETIPIVNTHPEAEASRDLRLLNPWKELSEFTEVLTKDIEQMNDHKHSHIPYVALLLYFLTVWKKDHGRFPNSYTEKLEFKKIVAAGRRINLGSTEENFDEAVAAVMRNIKLSTLSVATQKVFEYQPNEKEAKSNFWIITNAVKQFYKKHNLLPLPGSIPDMKAESSIYVQLQNIYKEKARKDATEILEIILKHPLGKNIQLVEVENYCKNAAHIKLIHTYNEKANDLKLVAKTEFENDEIAVVTSQPLSLLPIYLALRATSHVPTLSPKSIVSSIESDIPRIGLNKRIQKVSQEVSRAKGGELHNISSLTGGMVAQEVIKLITRQYTPIDNTCIFDGITSRMQVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB06</accession>
    <name>A0A0B1PB06_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative exocyst complex component sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000828">
        <property type="protein sequence ID" value="KHJ34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB06"/>
    <dbReference type="STRING" id="52586.A0A0B1PB06"/>
    <dbReference type="HOGENOM" id="CLU_011776_0_1_1"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="104"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="751" mass="87650" checksum="334343DF01B09955" modified="2015-03-04" version="1">MDSSTVKLTEILKYPDDIDKVSALKLEYVRKKAAVDSQLRSGLKEQLEITQSGMSRINDGQRTVQLIKEEMIRVDKLCAEAQNMIRDFPNINLVSLTHKNFVAVQKMRNDLQTFNDRLEFVEKMLREDDQDPENMPNLLAVHYELTQLRNIRDSAMEQVARADDKSLQNTLEDYFIKQDEVIEWFDEHIGMIALDIINVLINGNTSMIVRFAVIVEAEERSDKRIKAMQEALKDHKEMASRFQSITDGARTIKGYKEKFLLAIRLHADEQMSATKELFLQDPGRLEKSLKWFFNDLNAIKQGMVPLMPKKWKIFQTYVEIYHKTMHDFLIGMVDDPETSSANTLSILNWPEKYYAKMARLGFNKPDLRPHVLDERENELVKDFQQLIIRFLDQWLDRIFKTEQKDFMDRNIDGGNLNTDEYGYFRTKNLVDMWRMLAEQIEAAENSKRVDVLEGVIDAMILRLQTHQRNWQKMLDEEASKYLGSNPESEGFQALQDWLVATANDQIACIDDNEEEERFAYVTVFRQQFEPLVTPLYLERVEDKLNILRDGYVDLSTHCVAKFAQLIFSVDFKTVLPDFFTPKWYMANAMKQIVVTFEEYIGDYKAVLHYSLIDIFIEELADELLIRYLSSVRNKGAKFKRQDPFKDKIFSDVSVAFEFFNSGLLSPDVTDVIKQKWRVTENFLALLEMEKSSIPDLFASFKTDYWDLQFSWVEAVLRSRDDFDRGLLNAVKAKAAQISVARGTETLMSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBL7</accession>
    <name>A0A0B1PBL7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g1634</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01001077">
        <property type="protein sequence ID" value="KHJ34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBL7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBL7"/>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="OMA" id="WNDWRGG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="466" mass="52798" checksum="D3699A22074D4F4D" modified="2015-03-04" version="1">MAVAKTSTAMQTTNGAARNTKKYTPKTHIADEPITRANWYKHINWLNVTLIVALPIYGLMAACWTPLHWKTATWSITYYFMTGLGITAGYHRLWAHSAYSASLPLKLFLAAVGGGAVQGSIRWWARDHRAHHRYTDTDKDPYSVRKGLLYSHIGWMILNQNPKKIGRSDISDLNDDPVVVWQHRHYIKTVIFMGMIFPCLVTGLGWGDWMGGFIYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHAITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWCIWFWKQIGLAYDLKQFKQNEIEKGRLQQLQKKLDQKRKQLDWGIPLEQLPIISWEDYQAEAKNGRGLIAVAGVIHDVTDFIKDHPGGKALISSGIGKDSTAIFNGGVYNHSNAAHNLLSTMRVGVIRGGCEVEIWKRAQRENKDISFVSDTAGTKIIRSGHQVTRISEPIASADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBQ0</accession>
    <name>A0A0B1PBQ0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIA large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000710">
        <property type="protein sequence ID" value="KHJ34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBQ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBQ0"/>
    <dbReference type="HOGENOM" id="CLU_030027_4_1_1"/>
    <dbReference type="OMA" id="EVCDASQ"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="395" mass="43383" checksum="CAEFDEC8E418FE95" modified="2015-03-04" version="1">MSNTQVGVIYQQIIADVIESSRVDFEEGGVDDSVLEALRKGWQTKLTQLDVAAFPWDPKPEVVPPFSNAPPSVSTNGGSYQHINNQVAPQQPLQQVGLSSTNAPHIKTEPGTENSSINQYSSQISSLPHTATTAQQRAAAHLHNNYGPRAAASINAIQQGASHNQQGGPTFQQIQIMQQQQQLQLQQQQSAQQITQQEYQKKITPGDQNITNLQASRPTSDLGNAQTDGVGNDFSLRDTDGASRAIKIDKITLCRTEIDSLIRTKVKAMGTSIEGGGLMIPLRQLSNVARNPPQKKFSSSSIITAQMDGGEDDDDDIKYDGENLDEDAINSDLDDPDEGLNDDDDDEDGMGHIMLCMYDKVQRVKNKWKCVMKDGVLTVNNKEYVFHKASGEYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC34</accession>
    <name>A0A0B1PC34_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 26s proteasome regulatory subunit rpn9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC34"/>
    <dbReference type="STRING" id="52586.A0A0B1PC34"/>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="164"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="43554" checksum="A05890D687A9FAFE" modified="2015-03-04" version="1">MNTFSIADFLGEQRDAAPTELEHFFLTFEDLWERKLWHQLTDSLIEFFNEPESKSQRLPLYKSFILKFADKINQLKLVTLALTAASQCTDCQERLSFLKSVATKVNNPNSQDAYVYATVAVASVKLELHELEDARKDLDLSEKILDKFDSVETIVHAAFYRVNADYYQAKEDYASYYRNALLYLACIDVNILTPPERRKRAYDLATAALVSDTIYNFGELLLHPILESLKSSEPNLCELLFAFNRGDLSTYDVLSGHIASNPLLFRHSDGLKQKIYIAALTEAVFRRPPHDRAMSFKTIVEETRVRPDEIEYLIMKALSLGLLKGTIDQVNEIACINWVQPKVLNMKQIDSMRVRLQEWDSSVNSLGNWIESKGQDVWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCA4</accession>
    <name>A0A0B1PCA4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000800">
        <property type="protein sequence ID" value="KHJ34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCA4"/>
    <dbReference type="HOGENOM" id="CLU_036943_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="23488" checksum="8C7A34A473F46FC6" modified="2015-03-04" version="1">MMRARGLLNIVGPYLEEIETEFPGAGIEFLALITDGVSRAIRGEKILVKITDDPHKIVMIRLGKGHEARNTDSFLLRQQIQKLIPDPTLVSNTWQAPSGIKTLAPTPAKAAAILQYKDVIARRFSNATVERQELWAIFIVGPFPKLFTTLDGKQDPVNELPLQEPSLASLRDEVPIRQVAWKNRSKESTESTGHIRIHIPIYKVHKFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB3</accession>
    <name>A0A0B1PCB3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative enth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCB3"/>
    <dbReference type="HOGENOM" id="CLU_014248_1_0_1"/>
    <dbReference type="OMA" id="IESEQTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP180 N-terminal homology (ANTH)" evidence="4">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="538" mass="60490" checksum="CF671E0C58264025" modified="2015-03-04" version="1">MIREGAPDVTLSYLARNRSMLAISNFSDVQTQGRNIRHYANYLVERAAAFRETKCDFVGGAKCRLDKLTVEKGLLRETEIVQHQINALLKCDVLDNEPENEIIITVFRMLVWDLLSLFQTMNTGLINILGHFFEMSKIDAERALNIYKNFTRQTDHVVQYLNVARQYEIKTKVEVPKLKHAPVNLGRQLEDYLRDPDFEANRIQYLKEQEAKNSRNNGGKIFPSRDEFQPRPHTSAGFTSAKISAPVKGPDPNLIDFFESIEQNQQPLMTRSQPTNDDFNNKNAAQFPLHENYLLQQNGFVPQQMGLQNPNQFSQILNTVTNPQHPLNRQNFINPNANENPLQQHFQTSNISSIVRNPISTNYSSPISQQYTGMSLPGTIQTTNPFRQSIKLPNIQPVSGLPQNSLSPISPSSSRLSTNPFAMSFNAPSHPFSPPPDQNYQQIQQSPMAPSINPVASGTNPFANSGAPNSINSGFSEKALTGQSHPSGNTNPFRQTNLISNPSALDWHNKQQPIGGGLDNLETIPVFPRPMQPQSWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH2</accession>
    <name>A0A0B1PCH2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000187">
        <property type="protein sequence ID" value="KHJ35958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCH2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCH2"/>
    <dbReference type="HOGENOM" id="CLU_007149_0_0_1"/>
    <dbReference type="OMA" id="VTTWQAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="536"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="875" mass="100633" checksum="CBA8E845DDDC0743" modified="2015-03-04" version="1">MPLNIVVQKQNVFLSVFDVDKNRIPTEFNKSSSSGGKVNEKWLDLNSFQSQWHNSWLLVTKTLELPKNFEKYGSLEPKKKLIDSKFKNALQILLRSKIESISSDENVDIVAWLSSQVRQHYVNQVLPCILQAKNLDTLEYDLFHSIGILESTRRLYEYKLLLIKQQMDIVSPGISITVISKFQRDLDAIISNTIIDSISIPLARTLNRYVAIALKLTLPNDFSNNSIHVENLDEEKAEEALIKLVNRLKYIGLAGEGFQIIFAEVLNNALSYFINGICHETLSLKLTTAAKESSSERKSIENFQLNHQRVSLNPSRCVKDIFEWIESRYAKLAFRVLGLLNNKINISWPEKLKFKDIGISRLANFRCKQLFSIVTNWPHNGEALDDLRTAINTPERRLHLTELFAKTLAKEVLHPAASTTRILKTYISMIWSFHSLDQSKVLLDKVSYPLQLYLYTREDTVRIILSGLLADTENSHSGNMGNKLLELAWLLNNESESISQKANDIGLDWHDMDWIPDPVDAGPTYKRSKNADIIGTLVSFLGSREVFIKEFQNILGDSFLKFDEMFSREIKVLELLKLHFGEASLQACEVMLKDIEISREVDSKIQEIIQSKIGISVGIQDNQSFSKVDTDISKTFLHAKILSRLFWPQLPNESFQIPPEIVELQTKYAKEFTLLKPSRKLKWLDTSGMATIEIELEDRTLIENVHTWQAAVIWAFQNEGIDDQPQKRTITELLNYLRMEEGLIRSALRFWVNKYVLFETSLETYVVRETLSPQDQANLNSGSRPLSKHDEKIFDNKLDAINSVMNEKMEIYWQFIQGMLTNSSRQMPLQQIAMMLKTLIIDGFPHTNDELKEFLKQKITDGLLELSSGKYRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCS6</accession>
    <name>A0A0B1PCS6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000737">
        <property type="protein sequence ID" value="KHJ34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCS6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCS6"/>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="OMA" id="YGLQQNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079916" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="8">
        <location>
            <begin position="282"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="7">
        <location>
            <begin position="526"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="819" mass="88764" checksum="D3EA741B2C28CBDC" modified="2015-03-04" version="1">MQFSSLRSRYTLYAITLAACVFGPCLSHSIERNPLRYYTTIENAHFNTQSYKIHAASKFELTFELHDGKQMIRLTLSPNNAVIQEGATVQYMAPDGSLRKSEILDRSEYRVFKGDAWIKHQNSQEWTNVGWARIIVLRDGEKPLFEGVFRLDGDHHHIQTSTNFMQTRHRLDPELKVLDDEYLVVWRDSDISQNVEIDNHEYIHQELKRSLNMERSCLADGLSFNTQLDHPIYRGMSTPGDQSSLLTRLLQPRQMDGQLGGNSAGVNLVNSIGSTSGCPTTRRVALVGVATDCTYTAGFNSTTAVRANIINVINSASQVYESSFNIMLGLQNLTISDASCPIVASSAAPWNIGCSNAIDIQGRLNLFSAWRGQRKDNNAYWTLLSTCGTGPAVGLAWLGQLCVGTSQTGPSSVTSMNETVSGANVVVRTGTEWQVVAHETGHTFGAVHDCTAKSCTDGKTVVSQQCCPLSTTTCDAGGSYIMNPNTSPKIQIFSPCSVGNICSAIGRNSVKTNCLTTNKDITTITGSQCGNGIVESGEDCDCGGSVSCGSNPCCNPTTCKFQGNAVCDPSNEDCCSSSCQFKPLSAVCRPSTGSCDPEETCSGTSGDCPADLTAPDGTKCGNSSSLTCASGQCTSRDLQCKTLMGVFTQGNDTYACSKGGCQISCASPEFGADICYSMQQNFLDGTPCQASGKCVNGQCQGASVTKEITSWIDQNKTVVILLGSAFGFFIALTFASYCINICSRARRRRRIMANVSHNDLQSHNYHKQFSVQDTSSFNTPLAQVSMQDVQNSLSYGKWDDRGNLIQQPRRVKPGRMTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD09</accession>
    <name>A0A0B1PD09_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000701">
        <property type="protein sequence ID" value="KHJ34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD09"/>
    <dbReference type="STRING" id="52586.A0A0B1PD09"/>
    <dbReference type="HOGENOM" id="CLU_116873_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="22562" checksum="C7A9706D1E2C4BF8" modified="2015-03-04" version="1">MNVLQKNTRTRPSRGHAPKPSYAQALTTKQLNFNTVNLPFNQNFPAPAQSSQNRRADNRIFVQLSEAHPSREHHIHAIKTALIQKLGPEGEAVKVISKVKSGMAIVPVDEKHAEKLLEESESIISVLGGKVDKAEEWITYVKNHVPRMLHSLAREEIQIIEASAKKEVEKITSLVPTRISWSKNTLANPGPTGIIVASFNKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDA9</accession>
    <name>A0A0B1PDA9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000617">
        <property type="protein sequence ID" value="KHJ34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDA9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDA9"/>
    <dbReference type="HOGENOM" id="CLU_000288_120_1_1"/>
    <dbReference type="OMA" id="DQFQGFS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="257"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="603" mass="67334" checksum="DD43C7FB1D8B0785" modified="2015-03-04" version="1">MKCHQTTYLSFSAASESIAAQKSVNPPPGILIVTLYEGSGFALPESYKHIFSSGHSGSVSQGNGFGVAGSVRPDSTQQQGNTNGSFSANARPQTASTNGFGNVPTNHGRISSKYLPYALIDFDKLQVFVNAVSGTPENPLWAGENTSFKFDVSRVTELVVTLYLRNPAAPPGTGRAHDIFLGVARINPRFIESHKYVEDPKLSKKDREKAASEWVKSEKSLGQSGAEWLDISYGSGKIRIGVDYRETKTQSFKIEDFELLKVVGKGSFGKVMQVKKKDTQRIYALKTIRKAHIISRSEVAHTLAERSVLSQINNPFIVPLKFTFQSPEKLYLVLAFVNGGELFHHLQKEQRFDINRSRFYTAELLCALECLHGFNVIYRDLKPENILLDYSGHIALCDFGLCKMEMKDEDRTNTFCGTPEYLAPELLLGQGYTKTVDWWTLGVLLFEMLTGLPPFYDENTNEMYRKILSEPLHFPGQEIVPPSAKDLLTKLLNRKPDQRLGANGASEIKAHPFFHSIDWRKLLQRKYEPTFKPNVVDALDTKNFDVEFTREAPTDSFVDGPVLSQTMQQQFAGWSYNRPVAGLGDAGGSIKDPSFVGSVRENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDH5</accession>
    <name>A0A0B1PDH5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60s ribosomal protein l16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000575">
        <property type="protein sequence ID" value="KHJ35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDH5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDH5"/>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="23001" checksum="4A30F5322CDA8617" modified="2015-03-04" version="1">MSTFEPVITIDGKGHLLGRLASIVAKQLLQGQKIVVVRCEALNISGEFFRAKLKYHAYLRKMTRYNPTRGGPFHFRAPSRIFYKTVRGMIPHKTARGAAALERLKVFEGVPPPYDKVKRVVVPQALRVLRLKPGRKYCTVGRLSHEVGWKYQDVVARLEERRKVKGAAYYAKKKALRKKLCDAQKNAGIDESIVKQLSDYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDL2</accession>
    <name>A0A0B1PDL2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nadh-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000077">
        <property type="protein sequence ID" value="KHJ36308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDL2"/>
    <dbReference type="STRING" id="52586.A0A0B1PDL2"/>
    <dbReference type="HOGENOM" id="CLU_1807658_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="143" mass="16325" checksum="72A9736E63D6B57F" modified="2015-03-04" version="1">MFELCYTKDYHTESNLIDHNYRIYFNEQPNTLTCNSGPRIMLSCIRRTCALNPRVKSPKRLLIAKQSIASITSSQNKTNAILQDGISKSTSLAAPPLSVTGKVRREVPLPSQEEKKGVMQYALYVLNSREILYRMLTLLWNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDW0</accession>
    <name>A0A0B1PDW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nicotinamide n-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDW0"/>
    <dbReference type="HOGENOM" id="CLU_032409_2_1_1"/>
    <dbReference type="OMA" id="RARWCIV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="289" mass="32272" checksum="1D2B64C1FD13A61B" modified="2015-03-04" version="1">MLTNKVRLKDDSSNAPEDIFSSAIAVVFPDEICNQHGDQFNNVIYDSTVCGEIELSLADPKIQNTQLFSHFLWNAAVQLSDLMEAAQGITEESLWNVQGQNVLELGAGTGLAGIIAYLLGAKYTVLTDYPSDEILANIQANVIRNTVSRIPSVNRDPSTIIVQGHQWGKFHDSFSLVHQGAFSRVLVCDCLWMPWQHQNLQASISWFLATGGLAWIVAGFHTGRKKLKEFFEINSLSRAGLILDQIWEKNADGTEREWLVDRGLENITEQKRWLVIAILRKDTNGSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDW7</accession>
    <name>A0A0B1PDW7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptide-n4-(N-acetyl-beta-glucosaminyl)asparagineamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000684">
        <property type="protein sequence ID" value="KHJ34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDW7"/>
    <dbReference type="HOGENOM" id="CLU_145544_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="140" mass="16468" checksum="91FC9C519B9065FA" modified="2015-03-04" version="1">MSIKCKLRPEHSFSFSQKKIRRTTKLRYISVLSPSSSRTAKEKRKGTKDDHKHTPATAVTTVNEALSKARECPECAQDPMIVALLDVTIDRIWKKIQTRKEYVMSRDEFSFFTYFQSRFEGLQITRDARKRYWDNMQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDX7</accession>
    <name>A0A0B1PDX7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative transmembrane gtpase fzo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2868</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000350">
        <property type="protein sequence ID" value="KHJ35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDX7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDX7"/>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="268"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="915" mass="102643" checksum="42FC3DD480028B43" modified="2015-03-04" version="1">MSEDFESEKERDLGEESWSRRSTSRPEYLTVGNGSTSENKVRLQALLESDSGYGGSCTGDSVKAWDPTLYNQSSLPQTSSTLRTEIIESQLNDRRTQTNAIHQLWYNQHRVTLARSINRVIETLSGLQEMNSVWPACYPTVQRAEIAQAYRRRSRPPLNSPFSSIRESKGHDAPHHIALHRAQTSPREDNTTDTENTPVAEQKPNLEPRLITPQIAQEFSILKLDLKLGAMLQSELVHSLEKGSIASLLDGKIRSSIKHLLSLRERIEDTSSKVLVTGDLNAGKSTFCNALLRRKILPEDQQPCTSIFCEVLDVRENGGIEEVHAVHRDAIYNRYDESSYDVFGLADLEQLVISNDVYTQCKIYIRDIRTIDESLLNNGVVDISIIDAPGLNMDTTKTTAVFARQEEIDVVVFVVSAANHFTITAQEFIWAAASEKAYIFIVVNGYDNIRDKDRCQKMILKQIAGLSPRTHKENAELVHFVSSNAIPTALPIPPYGNSDHGDGYPSGDPPDFDGNDPKGKGKAIEKEKIRDFEKLEQSLRRFVLEKRARSKLAPAKTYLLNLLGDLQTLADVNLVVAKAELDRVTRELNELEPILEQSKKAKEQVNDEIDRTIESTCKEVYDYTRSNLTSSLHYTSVSDLGISYPGLWSSFQYAEDLKDAMLSQISVSVTLCEEFARNKTIEGVDLIKELGVSQLGDEYSDLSFRSDVMFQRKKDILAKQIDVETEIWDFFDWSSILNQQEKMAGTGVVLTVATAMSGKVVGTWAWADGILTTMRAVGINNVRRVIVPGILVTAIAAMYYAFSQIPSSLPKRLSTKISMQLQSIDFVHRNSDRISSSVRKVLRFPADNLRVGLQRNLEQLGVKQTETKKIRGESEVARKYFSNLVNESRVVRNIVEAVDLEGSSHGITMNYEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE11</accession>
    <name>A0A0B1PE11_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative wd repeat-containing protein mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000493">
        <property type="protein sequence ID" value="KHJ35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PE11"/>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OMA" id="TEVCTND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="218"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1355"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="961"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1474" mass="168282" checksum="85C6C78A0719E31E" modified="2015-03-04" version="1">MTTVAVPHASPQRQQYPLKVQSEQENLIPSHHDQAQSHPSLQAKLHEAREQNRIFGSANSQASISDVSSNVLNGTSLHGSKPLNNTQFQILRHFSLSDPTVIFPETTKINGSQSFAESSIHMLVSSTEPNSKSLGPPEEIQNEKENVKTGEDEKGKQNDKEARGWGTRHGFEDHYSSEEYVSQLANNWYMYFTDKRHETTGNPKVTGFQLQEWRMRDRLKTISAALAVCLNIGVEPPDQLRTNPGALLEAWEDPMCHPVQKSLENIGKSLQEQYETLSIRTRYKQYLDPTIEETRRFCLSLRRNAKDERILFHYNGHGVPKPTPSGEIWVFNKNYTQYIPVSLYDLQTWLQAPTIYVWDCSGAGNILCNYHRFVDKHKHEEAEIEKKDRKHIPQKYEPYIHLAACNANENLPTNPQLPADLFTSCLTTPIEMALWFFVLQTPLTIKMTPERAKKMPGRLQERRTPLGELNWIFTAITDTIAWTTIPQPLFRKFFRQDLMVAALLRNFLQCQRIMATYKCHPLSYPQLPDTTNHPLWASWDLALEMALAQLPMLEDKDSGLNPNYEFQNSTFFSEQLTAFEVYLTQGGGAAGKAPEQLPIVLQVLLSQQHRVRALVLLGKFLDMGPWAVNLALSIGIFPYVLKLLQSAAHELRPVMVFIWARILAVDITCQADLLKDKGYLYFATILKPNEGLPVVDSLEHKAMCAFIMARLCDGFQSGQITCNQTDIMSYCLVHLQNLDNPLLRQWACICISQLWNDFPDAKWRGIRENTLVKLAFLIRDNCAEVRAAMLYAMTLFLGMAELTDEVVRIEENITWTIIEMVKDGNAMVRKEVLVYLSKFIHRYENRFFVAAFEQLREERDYKEYPPSEDENNSNMGLHYVKMENHSNDGTIKDIAHGLSHNSIFAMVWKHILIMSVDPHPEVQQNASLIVDYVYCSMFQSPIGNFAEVIIDDMKKIVTKSPNFSQKSTETRPNTPNRQGPVVSVPQTQGLLKRTASYLFAPFSVMNTESLSDSSNKQTSRTTSSQRNSLPIRNRPSLVTNAPYEKDEAVKITGGYHLAKKPTPGGFRPRNIADTPTIPLKSNFYDWSIEYFKEPQMKQHETEEPGSTEYNERLWRCSRNEAILLETQSQKDIAANGKWNIPSGVLNNNSQPNKMIYHQFEDHLAISDDGDTISIWNWRKQDRLNKFSNGNPENSKINDIRFINEDDQALVMTGSSDGVIRVYRNYDNDKKVELASAWRALTNLVPSNANVGMVLDWQQVNGRILVAGDVKVIKVWSAASELCLAEINARSGSCITSLTSDQMTGNIFVAGFADGAIRIFDARNKPQEAMVKRWKDDTDNVWLKCVHMQRGGQRELVAASRNGKVRFWDIRMDKPLRTFRTTNQVLRTASVHEHFPVFSIGTGNHTVKVFNFAGKELSRFQLYSNFLHQTKQNPIFATTFHPHRMMLACAARRDYHVNMFTCSENQNTLDLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE65</accession>
    <name>A0A0B1PE65_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative conidiophore development protein hyma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000317">
        <property type="protein sequence ID" value="KHJ35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE65"/>
    <dbReference type="STRING" id="52586.A0A0B1PE65"/>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="OMA" id="AYDHKES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035839">
        <property type="term" value="C:non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071574">
        <property type="term" value="P:protein localization to medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="43275" checksum="29FAF13E7D440159" modified="2015-03-04" version="1">MSFLFGRRLRTNTDLPKQAKELITKLDGPAGVAKVDELAKTLVQMKLILQGTQDTESSPEQVYSLVSGMIQEDLLYQLALNLPRLTFESRKDAQVIFSYVLRFRPQTASPKSEPLALSYVINNRPEVLVTLCNGYDRRESALAAGTVLREVLKSEAAAAIILYDDPSEDGHNSSKGLSGVNPEVKQSGRGVFWKFFKWIDQGTFEVGADAFTTFRELLIRHKSLVAQYMATNFDLFFDKYNNILVKSSSYVTKRQSIKLLGEILLDRANYAIMTAYVDRGEHLKICMNLLRDERKMVQYEGFHVFKVFVANPHKSIAVQKILLINRERLLNFLKGFLEDRTEDEQFIDEREFLVKQIKNMPGTPVEPIHKPALLQGVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEC7</accession>
    <name>A0A0B1PEC7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000455">
        <property type="protein sequence ID" value="KHJ35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEC7"/>
    <dbReference type="STRING" id="52586.A0A0B1PEC7"/>
    <dbReference type="HOGENOM" id="CLU_084513_0_0_1"/>
    <dbReference type="OMA" id="HGIPYVY"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="238" mass="26284" checksum="7AB6F8AF5628F7F5" modified="2015-03-04" version="1">MSKEKHDKKVKINKLSETEGIKKSKKDKKHKRSETDGVKKIKKEKKLKLTEDNITAVIAEVEKAAPPPTVLKDEKILPIEKDLFIPRPIGSLVPFANPLADERITKKVLKSVKKASKVKTLKRGVKEVVKALRKSPQGVGNTSAPGVVVLAADISPMDVISHIPVLCEEHNVPYIFVKSRAELGSAGNTKRPTSVVMVSETRANGSKKIEVIEGSEEFKETYKKLVAVVEKEAKLVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEG9</accession>
    <name>A0A0B1PEG9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000563">
        <property type="protein sequence ID" value="KHJ35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEG9"/>
    <dbReference type="STRING" id="52586.A0A0B1PEG9"/>
    <dbReference type="HOGENOM" id="CLU_017274_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="599" mass="66871" checksum="A1C376EF86DAB336" modified="2015-03-04" version="1">MPDAELLPTRPDWRDQYSSINLLEEQSSSSPRLPPCTFSNGCLIMMDQDGSRSILEQQTSHTKPSGINQLDSMVDGLKWNSEDRSSPCKSIDQNCTLLCRESASVALGSISSNSCGPVSRDSSRSAKMENDGDGDGPELELKNEEEELEEEDDDDMIDVELEEGLIPKSEAERRAERRKMKRFRLTHQQTRFLMSEFAKQAHPDAAHRERLSREIPGLSPRQVQVWFQNRRAKIKRLTADDRDRIIKMRAVPENFDNVKALHSSYGAVHMLSSPLKSPVGFGPSYSEHLMRPLVIDSTKNQDGNISPTVSSPAFSHVAFSSNSSLRSPDLLSASTTLTSPERYYSTHISGPMSAGPRATLSFNRPNNILSPSQSCHPRHVARSLQPSQLRDTISKLRPDSLQSPLRLSMSWKGENLNYCENNSTGQPSPQFSEQQPSQDQHEFQSSHEVDSQQFDPNTYSNSNNIENSPTNVYNASPNSSSFLENPDLLSLSRIRATSTNAFPGRLDVRNQFQPRNPPSLATPLVNSFGNSFTPGFVSASPTTFMNSPHEYIDVSNQKLNHLVPEQVEDKLFDTTEPVEGSRVESTEQCQGQLMTILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEN5</accession>
    <name>A0A0B1PEN5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000266">
        <property type="protein sequence ID" value="KHJ35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEN5"/>
    <dbReference type="HOGENOM" id="CLU_071100_0_0_1"/>
    <dbReference type="OMA" id="RASGWFK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22284" checksum="52601261075F8B33" modified="2015-03-04" version="1">MSTCFQLPQITPINISLTEGTDIPPPPESPNRERPSLDDFQWTAADEENPPSLVEPTTNSSSGQDVDEEATYKPLTPPNHTPKKRPSSIRKFLSRRSLHVNYTNENNYVSSQPRPESSMSYASASTCFSNGKKRNFSWMGRFSGAGDVFLKKRTSIVIEEKIPLEPPPPPPMLPQLSQFKATISEFDVGLGGEDLFKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFC0</accession>
    <name>A0A0B1PFC0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative solute carrier family 25 member 33 mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000166">
        <property type="protein sequence ID" value="KHJ36010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFC0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFC0"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="166"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="282"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="376" mass="41550" checksum="280C7DCF08A5460F" modified="2015-03-04" version="1">MNTYTGSDHRYGSEKKTNQIHKVLDTNGSQTRFTTSIATQPTPIAKSWAHFLAGGAGGMAAATLTAPLDVLKTRLQSDFFQEQLAQSRLSKRVSSQNFVSPFRSGIQHFKETFQILGSVHRIEGWRALFKGLGPNLIGVIPARSINFYVVGNGKRIIADYGNGGKESAWVVLCAAALAGIITSTVTNPIWLVKTRLQLDKNFVNETGGKALRKYKNSWDCIKKVVHNEGIRGLYKGMSASYLGITESTLQWVLYEQMKASMARRVELINQTGRSQNLWDKFIDWTGNVGAAGGAKLFAALITYPHEVVRTRLRQVPMENEAPKYTGLLQCFKLIWKEEGTAALYGGLTPHLLRTVPSAAIMFGIYELILKLFSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFV7</accession>
    <name>A0A0B1PFV7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g6167</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PFV7"/>
    <dbReference type="HOGENOM" id="CLU_000430_4_0_1"/>
    <dbReference type="OMA" id="QQVGYEE"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="583"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1382"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1722"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="225"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="402"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2102" mass="235051" checksum="5AA9719DD3C67F04" modified="2015-03-04" version="1">MTKRNADTCENNIASYDDQSTEVLGFPSSPVGMKNDGNKLLPNTRINNKYPRTIISKQALDACCQEKDKCQSYSDHFICDFPALKTDGSRRPLQSQDNCRAPTGTPNISASWMTLTSAPLSAGFGTKFFNESSEKTTRDSSSPLAFNRNVDMKNVLGGLPLKEDDGRRPSVASIKTSSSQSSKSSLNPAAIHKKLQAFFGDDFIGKERSDSSINLQGKDVLTQTLMRNQAHRTTSPTTDTIRDTTRQHEDSPTNRRPNTPVPSRDVVPFLYQDSQDIPKYGEAPVREKLSGPDKDRYSNEKVNVSKVSPRSLTQHLLPANKILDSDSEELAMNFRHNGRASTLKASLLTISNSNQRIRSKSPNTNNWNVTIQNNRSFSDINSPPISTKRGILGRFRKHKDFGPVRPKEITNSARSFNSTALRPDSSTYPTSPEKIVRSKNGDGSLGSEVSVSKSDGSRHIYPSNRQGTFSKLQLLKGRNRNSDGNDSHFEYSDNENTSGLLFNLDTNLNNMEGILAKPPLLTPLDKNALGKFEDETKNLPEINGSLGWNAPESWAVKKIHDDTISQAEADQTYMPPRENEKLKSYCIRIFRLDGTFATLSASLDATVAELMGQLGRKTYMTDTLANYQIVMKKHDLHRILGPAERPVVIQKRLLEQVGYEERDRIEDVGREDNSYLCRFSFIPARESGFATITADPGISRVQKYSHVDLSGRNFITIPIALYSRASEIISLNLSRNLSLDLPKDFIQSCQNLRDIKFNNNDAWKFPTSLSRAARLTILDVSNNRFEQLEDAELDRLVNLLSLKLANNRLGSLPMYFGSFKSLRTLNVSSNFLDNFPKFLCDLESLVDLDMSFNSISSLPDEICQLVNLERFVITNNRLNRSLPDTFCQLVNLKEVDIRYNTLSSIDVVASLPKVDQISADHNSISVCECEFSNIRILRLNSNPVTKFEILNLVPTLTTLNLSNAKLAHIPDANFDKMPNLVKLILDINHFVSLPIHIGKLRKLEHFSIAQNALSSLPAEIGCLTELRFLDVRQNNLKKLPIEIWWANKLETLNISSNVLENFPMPASRPPQVPGDILPISHGTVSNTPGPNSTTSSVEELGALEAFGHRRPSQLSNSLLGINGSPLSGITERRNSIVTTYGKRGRQPSIVSRTTSEIGNATPSPPQTRKDSILSSRLVNTFAKTLKNLFLADNQLDDDVFDKLILLGELRVLNLSYNDLSDIPHRSIKSWPQITELYLSGNELTSLPSDDFEEFSLLQVLYINGNRFQTLPAELGKAHRLAVLDCGNNSLKYNVSNWPYDWNWNWNTNLKYLNFSGNKRLEIKPSAPGSAGNRDGRDLTNFNALQNLRVLGLMDVTLTIPLIPDQTEDRRVRTSGSLAGQLSYGMADTLGKNEHLSIIDMVVPRFNSSEAELLMGMFDGQALASGGSKIAKYLHENFGRIFSEEMKRLSSTHGETPSDALRRAFLSLNKDLATAAIQNTEERTQLSHRGTISAPPNGALTYSDLQSGSVATVVYLQNSELYVANVGDAQGMLIHSEGGHRILTRKHDPAEPNERQRIRDAGGWVSRQGKLNDILEVSRAFGYLEIMPAVQAAPHVTHVTIKEQDEIILIASRELWEYLSPELVVDVARYERGDLMRAAQRLRDLAIAFGATNKLMVMMIGVSDLKKRNLRTHRLQGLFLNSGTFFDDNYAPMRRPRKKGENIDDSGLRRLDAEVDAPVGYLSIVFTDIKSSTLMWETFPSAMRSAIKLHNEVMRRQLRLIGGYEVKTEGDAFMVSFPTASSALLWCFAVQQALLEVQWPSEVVSSVLGQEIFDDDQTLIFKGLSVRMGVHWGQPVCEPDPVTRRMDYFGPMVNRAARVASVADGGQITVSADFISEIQRCLETYNDNDRSDSTGSEDTFENEVNSQAIRRELRSLSTQGFEVKDIGERKLKGLENPEYIYLMYPHTLSGRFHYHQRPAEGDTLVAVEGSAKLSDASQLEIDIDSLWSLWHICLRLEMLCSSLEGSKNSEIDFNSPEIIVLEKFKSRGGEMTDRIIIRLLTHQITRVEACINTLEIRHLAIGGCLIHNISQLQGPMKDIFSSLSAQLEGFQKYRAKYGDLTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGA6</accession>
    <name>A0A0B1PGA6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000321">
        <property type="protein sequence ID" value="KHJ35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGA6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGA6"/>
    <dbReference type="HOGENOM" id="CLU_005116_1_0_1"/>
    <dbReference type="OMA" id="HNGCEAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="VRR-NUC" evidence="11">
        <location>
            <begin position="834"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="960" mass="110829" checksum="A7D947CF89671ECA" modified="2015-03-04" version="1">MGKHETINAVSSSTNIFPTTFFYNSNQLEKSASKIKSQYANTVNLTQPLSSSHRKNQNHTQATKRLKVNHSPKDENDVNVITTNSNEKNKAPNLFNLLPNQSGGKNDGEDRVLNKNPGMKNDDLGCELSIEEETVRETDLELALPMTISQVDAESVIKDYKIIQSLKNEPQEEKLGLSQTSIIDYSIHHDSDSFSDSRSSIYVDAFNLVLKTVLQDEGHLFNVKELEVFKNWRELDYEAQYLYTRLFLRKSSVWHRINSLKYYSDISDLSVAAKKLQSSRDFSMPYVQTELDTTMTDFTSEGEIIELGSSFTFADSSTDNITTLEEASSLLRLEELKIISKDAKVGGKNKSEILKALCKTSKCQSGLDWKKLKRPNSNSKLGNQSNPATSSSHEIDRIEDVRPDQIYFQKIMKIIGPCIRLSLPILKLFERVHLVFYRSTEWTEKSLITIILAQISRRNFPQYIISRSANIFASRSDLLEFEASLQMQFHVDQLLIEKTSNRSDQEVKFKKILDIVDQAYPRWKTLVQKEKRLDDSFKNNSTHRKSDSLLTEISGEGAYLRRFSPAWVYTRILHKGLYILGRLKQYEREYDLVTELLSQKFFHLARRGPWYQRKALLEEHYMYQFRRPPSKQQLINLPEQLEDKLLKKYWKQIALSTCEIALQDKDCHQIFHYDLQKRIYKLEKQIKIPKREKHDFAHVLLCKPTEVWIEGIQVVKECNKNITISGSKGSNSHLNDERNKGRSTKTIWINEVEGNVESGVEEMCLSVYRTRGYKGFHAEGGILLTLFAFLFYDILFLYVPNVFQTAYQTCPLDLFSDTFYQSRASEINHRLAAIENGAAAHFIQMVDEKERHKRTCVVGLNWEYATHDLLEVVTCLNPNALATICRVLAQEYRIRRGGLPDLLLWHMGKREVIFAEVKSANDRLSETQRLWIHILTSVGLKVELCHAVAKEFRSSTTTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGM7</accession>
    <name>A0A0B1PGM7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g1212</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PGM7"/>
    <dbReference type="HOGENOM" id="CLU_000315_26_0_1"/>
    <dbReference type="OMA" id="NLLGFHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="563"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="813"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1384"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="193"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="447"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="755"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1563"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="379"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1563"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1599"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1618"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1630"/>
            <end position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ36405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1662" mass="188055" checksum="4172B76DE98B5A19" modified="2015-03-04" version="1">MRRSEGLAGEDGARREGLNGVISSNTQTFAARSPTLIDVQFPFSPANGKPPPHPSNKYPAPSTFALPMQSSTSEIPSTQLLASPRTLSTPNSSDNYRSTSRNYYDPTSDSSNRRTPDTTRWTDVQAHKSQISAPQKFSANVGHIKFNNTITSNPPVSSLPSQTSLCHIDSPTRLASTLPSPLMASITSPGLPHSGAVARASRPAVETGSTINSSRPVDPMAFSSILSSSEPILKPSPKQAGQKKPTKNQAIKSEKLNSPLPLQTPTNSRVPAKRKANGEPKGLYESPKTALKDQENGLQVIVAQIDADASDIENEEFQKNKQTFSVLGLKRRLEVENLELQRTKKRRSSFMNIMAVKFGRHAAFGELRYRDVYLDSAITKVQEKEIMAEKERKKDMQRKRRREKTVAANIEQKEIAIQKAKAAENEAERLKFIKEAQRAEKKANQTKIILEQGDQKSSGVSPIAQIESKIDGNTLPSLVNSDETPKTKSKRGGTRPRKSKEQKQAEKDSAEAAQAAIDAGDESASLLSIKEEPKLRLKINRDDSPATVTPFVSKGYNQIYDQIWRDLARKDVNKVYKIAGESCATKVSNLKKTAILASKEAKRWQLRTNKGTKDLQARAKRVMREMASFWKRNEREERDTRRAAEKQEIENARKAEADREANRQKRKLNFLISQTELYSHFISKKIKTDEIERSTDLPDIDKTKTQASEQIVDHHNQNIPESCKVTCFEDLDFDADDDSALKAAAIANAQSAIQEAQSKARDFNRPDDSPTLDEEGEMNFQNPAGLDDIEIEQPKVLQAQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAEKHGIWGPFLVVAPASTLHNWQQEITKFVPALKVLPYWGTGADRKVLRKFWDRRHMAYTKDSAFHVLVTSYQLVVSDVSYFQKMKWQYMILDEAQAIKSSQSSRWKVLLSFNCRNRLLLTGTPIQNNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKHVQKELGDKIEIDLFCDLTYRQRAYYSNLRNQISIMDLIEKATIGDDNDSGTLMNLVMQFRKVCNHPDLFERADTSSPFSFSSFAQCGSLLREGSYVEIKYSTRNAIEYNLPKLIWRNGGRIDLPGQDNCVAGFKRKYVNELFNIFNPEYIRENMTENNAFSFIPLSGASIRYISRASQKCLFDRAVDLAQESCHLGLLNVIYDEDDYNFHPHHMLKICDRNNPRLISQNTNEGYLDKLFNIAKYSWDESGLSRLEPCGEAKATAPPIEVTCYSSGTNIEREKILFNISMRRALFGPSLAEERALITSQIDISEFPLQKMLPTPSSEIKRFTNIQVPSMRRFVTDSGKLAKLDQLLFQLKEGGHRVLLYFQMTRMIDLMEEYLTYRNYKYLRLDGSTKLEDRRDTVHDFQTRPEIFIFLLSTRAGGLGINLTTADTVIFYDSDWNPTIDSQAMDRAHRLGQTKQVTVYRMITRGTIEERIRKRALQKEEVQKVVMTGGAGVDFNTRSKENRTKDIAMWLVDDDEAAEIERKEQELAEKEAKEPEKKKGKGKSRKSEVKSTAGSLEDLYHEGEGHFEDKSNKAPGSVTNIAGSESSLKSKKPRKNGGSKKAKTIKQKLAMADGNEDIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH26</accession>
    <name>A0A0B1PH26_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000250">
        <property type="protein sequence ID" value="KHJ35794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH26"/>
    <dbReference type="STRING" id="52586.A0A0B1PH26"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="540"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="191"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="814"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1253" mass="143757" checksum="547B8E092F3751C4" modified="2015-03-04" version="1">MGKLIRLELFNFKSYKGHHTLLFGDAYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSAHLRDLVYRGRVLKTSKAGSGNDDQDEEKNAKEVVDSPASVNNDPKNAWVMAVYEDDTGDEQKWKRAITNQGVSEYRINDRIVTALQYNEALESENILIKARNFLVFQGDVEAIASQSPKDLTKLIEQISGSLDYKAEYERLEEEAKKTAENQMYNLSRRRGINSEIKQYQELKKEAETYQAKARERDQATVTHILWELYHYQSEMDKSIASIERHRETMKEYVRNVEKYEKSLQEARESHHKVSKDVSRVERMIKKKEKEIEDRENSLVPVDEKLEITETEIRKTCKKIESLSKEKEKYSGELNKLKKDLLSIDKVQKESENKWQETLKKQGKQLSDADFKEYNALRSQVATKTANEKATLDNLSRQMKIDDVAVNGLSVKVAASQVTFERLQVEVNEITERKESTEACLKDISKLIESKKTELNQMISERIRLNQLHTEKEEKLQAVLKEIADADAGRQKSMREQKMKETVAALKRLYGGVRGRVGDLCKPKQKKYDEAVITALGRDFDSVVVDSERTGTECVQYLKDQRTSPMTFIPLDNIKVSAPDANLKGLPKARLTIDTIDFDPSLERAMAYACGNSIVCDDLAAAKHICYERHIHVKAVTLQGYVIHKAGLMTGGRGPEKADKRKFDDQDIDKLRSQVTRFQNEIDALPDYYHRRTAEEALQNELAGLDQRLLRTKSELEAFEQNLHSKEKQLTFEQRQLQEMQPKLKEKTDSLQRITQNFVEAQSKFDHAQDIVFAEFCKRLGYSDIRAYEAQQGSLEQQIAEERNKFKKHKAGLQNQIDWLKSQYDELSRRISVINSRAESLQDQISQYQEEKSKLDEAIEIDKAKITDLEDELQKLKEKLAIRTEKVNQIRSNLSKQNKNIEEINKEISVLEMKAQRKSAERYSLLRRCKLDQILIPLKPGSKKLDSLPVEENSLQTDADAMEIDEVDTSLERSIKDYGIIVDTDNLDEELTKSGDEAIGERLLQKINDLNSELEKLNPNMRATERLDAVAARLQTTDMEFEEARKAAKKAKEEFEKIKEKRYDLFNKAFTHISEQISHVYKDLTRSPAFPLGGQAYLDIEESDAPYYSGIKYHAMPPLKRFRDMEHLSGGEKTMAALALLFAVHSFQPSPFFVLDEVDAALDNANVEKIKNYIREHAGPGMQFIVISLKTGLFQGSESLVGVFRDQEANSSKTLTLDLRKYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHT9</accession>
    <name>A0A0B1PHT9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative neurofilament protein h form h2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000056">
        <property type="protein sequence ID" value="KHJ36356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHT9"/>
    <dbReference type="STRING" id="52586.A0A0B1PHT9"/>
    <dbReference type="HOGENOM" id="CLU_628811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="436" mass="48731" checksum="77E04EB1F6B555CD" modified="2015-03-04" version="1">MDPTLWLYTSLTSGSSHIITATSRMETILKANRIPFKALDLATDEKARMLWGRRAGKDQSGRQRKIPGLVQMGMVIGDIVEVEDWNEYGELKQHIKIVPVPGAPVYPLAKVVKSNQLNKPEVSHDSFKLKYSNNESINDLKDNNDKIDHGTNKSDEKKIEIYGADISPSSLALRQLGKEAAQKAKETKTLKKTKEAEFIGVGIAEPQKLDITYIEKSNPEKIKIEDNTECKKEAGFMKIKTVEKEKENRVIRNESQKDLNLKDLYQDESLLQNIESDKKQRLVCEVNLSKGESINTAESEKKASDSCSMLENKDFSIKKPGPSQKIDSFNKIRTEKKPLKESLKRPAVILPPDSICIHKIYGSATNNASSFQSPNSCAWKNSIIQFASLEPPADRMESIQSPNSTAWKPASLDQRLSEVTLAEKVSETVTPKAGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUX4</accession>
    <name>A0A0B1NUX4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004910">
        <property type="protein sequence ID" value="KHJ30167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUX4"/>
    <dbReference type="HOGENOM" id="CLU_1062438_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="27848" checksum="2FC007668200E149" modified="2015-03-04" version="1">MPLTFDPENIRELQQTNILYIQGITIQKAAWLKNLKIPGKLSGSLILWLKSAEQARYVIMKGMILKSQQKAAEIFRSGFRIMQCFNCQRYGNIAKACTVIARCGACAEEHNSRECSGKNEIRCCECGRKNRAWEPSYLVRIAAKAKTVVNRTQDPGRYRLPESIQRDTEREWQIVGSRKRRASTTGQQVVGADSEIISRRGPERPKKNHAITPYTSTMWTEQPTPSHQNSYRPVTCENIRSNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVA4</accession>
    <name>A0A0B1NVA4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004612">
        <property type="protein sequence ID" value="KHJ30267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVA4"/>
    <dbReference type="HOGENOM" id="CLU_2122891_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="12151" checksum="E3D4C9DB77B87B06" modified="2015-03-04" version="1">MPSRAYWAFTPASREGDDFDFAGWGPLCLKARHTYTSVSIYLPMPHSQPLSSSNATTSPHLITHLKEPLALHYLSSPANQTKAIFGCVAAGKNPPKTTGCGAPLVPTSGLNPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVX0</accession>
    <name>A0A0B1NVX0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004065">
        <property type="protein sequence ID" value="KHJ30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NVX0"/>
    <dbReference type="HOGENOM" id="CLU_1147915_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27447" checksum="6B1A4E43D5A8D9DC" modified="2015-03-04" version="1">MLIPTGPSKRVAQNVAEQASQSFEHESDQSYASLPQELRQIIKQRRRRERAWHVRLSICTSVICNIESTLLVFKDDIEKEEADIIRNYLQQAIARLAASDNAPKLFVRLSKEHEWRKLSPAGIREMIVKRLHVSPASIGLIKPVRSGFALSPCSREAREELLKVSGGLFLSGAKLEPANQWVPLLIPTVPRSINTLQGHMEVTKEXXXXXXXXXPEALKFYGNHKPDAPHRTWLVSQYRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW41</accession>
    <name>A0A0B1NW41_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mfs drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003899">
        <property type="protein sequence ID" value="KHJ30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW41"/>
    <dbReference type="STRING" id="52586.A0A0B1NW41"/>
    <dbReference type="HOGENOM" id="CLU_000960_8_1_1"/>
    <dbReference type="OMA" id="YILWSIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="275" mass="30188" checksum="D3FC0E2866DA45FE" modified="2015-03-04" version="1">MIFKSRMVLATTAITFLSGWNFLVQIYFIPSFYQLAFGYTPTRAASMLLPIILVQTASSTLSGLVVSWRGRYRESLIFGYILWSIGLGLHCSLTPSSNLATQLGYGFLLGFGTGQYFQPSLIAMQAAVTKEHMAVITGVRSYLRCLGGTFGLAITGSILNRILLNAFHYASKHGLAALSSEQIKQILRNPTSLASITDSKILDKADVIKSLTLEAYFEGFRRVFYLSTALGIVSIVVTIFFIPQIELKIEKSQKEKELESSVSSSVVSISKASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWW7</accession>
    <name>A0A0B1NWW7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003553">
        <property type="protein sequence ID" value="KHJ30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWW7"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="OMA" id="AKNVHPA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="291" mass="31261" checksum="C395A8D418466B50" modified="2015-03-04" version="1">MYNVLAGTYVLQGVDVLNSLVHSTSTLEKKEGLAPDLIDIDAIESAINQNHSPDIEMIDEEIDRLIVIGLESSRWVTKAPTISEKDSTPFIYAVDKPKSADRIDSPISFPTQVVQEQSYTPPTSEEPVVVDLCISQASSITSLTNMSRVAPTVTENTKTLTCPLELLAGVEAEKRRIPQIAANIEACIVAINIVEAALATLDTGSQNNFVVSLKVYLRSAIAHFLRSGTAATTGSYPAVPIIKNAAKNVHPAKFNTFQAAQNKAGVTWATIAQKGHQKSPAIAGLRQNVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX76</accession>
    <name>A0A0B1NX76_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003936">
        <property type="protein sequence ID" value="KHJ30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX76"/>
    <dbReference type="HOGENOM" id="CLU_049841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="32989" checksum="BC8887406F0AB5A2" modified="2015-03-04" version="1">MEQITILIITFDKIQKTLSNEWQSEVVMHNKIISACKDIEACKMACYRPSLSVSGLILDLKSGVEIYNKPLPRSITSTYHTESLEKPPSDSNTLLIIRDGKIALKLVISEIGNKRIGSGKVGQTERYHDRSEKSNQSSRRQQNNKPGWICKQVGCWSNKHSTDERAAHKKSFIARLNNRARQYFGEMDDENDCNIDVEALIQDIEINDNESSENYTETFLTSSGVQISDQSSQNIIEALAAESNQHLINTISSNSPKVYDAASLISRYSAEVFRGILIDSGAASFSTAGFHQYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX78</accession>
    <name>A0A0B1NX78_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003373">
        <property type="protein sequence ID" value="KHJ30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX78"/>
    <dbReference type="STRING" id="52586.A0A0B1NX78"/>
    <dbReference type="HOGENOM" id="CLU_861059_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36971" checksum="F652819385A1811C" modified="2015-03-04" version="1">MDQSREEALLKQVPDNFLITPNNYRPQGRDPTERYSGDSPEKYAVWRYEVDQKFDDDQILFQTDLKKIAYARAQLTGDAFSHMTNWKMTTPLNDQTIESFFTEIEFFSGTSDLTELAQSTLLTIRQKSGENISKFYQRISVLWTRANYSEPERIRSFIKSSNPNLTRNILHLEFSRTQQILQALRTVENRKLGIDNHQPRGPLFRNLANAGNSNSKPIPSLSSPTNNKIPPKIQSFFPPTTVKPENWTGPWYQPEDNPAKLQPGESAVLAAQGRCFRCRGSGHKASDMTICPKKNKTSRFVNLLDVDCSKDESNDEDHLKAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY69</accession>
    <name>A0A0B1NY69_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003462">
        <property type="protein sequence ID" value="KHJ30918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY69"/>
    <dbReference type="STRING" id="52586.A0A0B1NY69"/>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="OMA" id="DADFGRC"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="29972" checksum="1D6270AEADA775D4" modified="2015-03-04" version="1">MDLNSETDSYYTSYWRDWFISSRGNEYFCEIDEDYLTDRFNLTGLNTEVQYYQYALDLIMDVFELDCDDEMREVIEKSARHLYGLVHARYIVTTRGLAKMLEKYKKADFGKCPRVMCKSHPLLPTGQTDIPNLKPVKLYCTKCEDLYNPKSNRHSYMDGAYFGTSFHNIILQVYPALIPHKSYDRHIPRVYGFKVHAPATLARWQNARRDELRRRLRRLEIESGFVEEDEELEENSEDEDGDEEIDVAPAEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYB2</accession>
    <name>A0A0B1NYB2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01003402">
        <property type="protein sequence ID" value="KHJ30963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYB2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYB2"/>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="547"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="631" mass="68556" checksum="0A0AA7748E75608F" modified="2015-03-04" version="1">MPSRVIVVGGGLSGLSAAHTIYLAGGNVLVLDKQGFFGGNSTKATSGINGALTRTQVDSNIQDSVKQFYDDTLKSARDKARPDLIKVLTYKSAAAVEWLQDVFGLDLTLVSRLGGHSQPRTHRGHDAKFPGMAITYALMQRLEELATLAPERVQIIKKAKVTSLNKEGNKITGVTYTFNNESNTVDGPVILATGGYAADFSETSLLKKYRPDTFHLSSTNGVHATGDGQKMVMAIGGNGIDMDKVQVHPTGLVDPKDPGSKWKFLAAEALRGEGGLLLNADGDRFCDELGHRDYVSGEMWKEKDRGKFPIRLILNSKASNVLDFHTRHYSGRGLMKKMTGKELAKEIGCSTEHLQKTFNEYNDIALGNKKDPFGKKFFHNFPVNVDDDFHVALMEPVLHFTMGGVEINDKAQVLNTEGKPFDGLYACGELAGGVHGANRLGGSSLLGCVVYGRVAGDSASNYLFQDALAGISTAKLRLNQISLHIDPSQPGKISVEWNSGKSISSSDSIQTKQSQASVAPVMSRDTESTDPGIMKEPAKSSKFKIPETQYSMEEVAKHNTKEDLWVVIKGVVMDVSNWLEEHPGGPQALMNFMGKDASEEFSMLHDDEVIAKYAPSQVIGRLKGQEITLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYX6</accession>
    <name>A0A0B1NYX6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative capsule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002740">
        <property type="protein sequence ID" value="KHJ31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYX6"/>
    <dbReference type="HOGENOM" id="CLU_005027_4_1_1"/>
    <dbReference type="OMA" id="HQPTWTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF104">
        <property type="entry name" value="PROTEIN CAP1, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05595)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="356"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="645" mass="74990" checksum="6419A0A8BB826BAF" modified="2015-03-04" version="1">MQMGNGHRHSVSVLPVEQDYRENLLELDNNHFKHSSISIAFLKTKRKLRSRQRLLAACLFLFSISWIIYTHSPVKSHKLWPSRPVKSDLLPLTESPPEIINLSQQNSTHPIWKLVHENQQQWEALLSKQSKSLSETVKEYRRRYGIPPPPNFDKWYEFAKARNIQLIDEFDNIQEMLTPFWGLKPATIRARAREAIGFDSNNLIGALIRNGELKKIAGGGEWQMNATAYMIKSFVNYLPDMDLAFNIHDEPRVLVPYEDLSRLVLIANNVNKPNANATREPKNAWSKRPLELGDGSRFDDVRRTRFNVFAHQATWTHARMSCPPSSPSRTLEDGPKLDNIYSYATGELGFVCNQTAFSDICFSPSFSETYGFFDRPNAFNVAHDLMPVFSQSKISSFNDILYPSPWYWSGKVPYEDSSDPAWTKKKDQMYWRGSTTGGFSRDGSWRRQHRQHLVQKINSNGNAKILVNRGNETGEDWQVKEISRSDYRELFDVHFSHVGQCDPGDCDAQKEFFGIKKQAKQNDAWKYKYLIDIDGNAFSGRFYAFLKSKSLVYKLAVFREWHAEWLKPWVHFIPMTLRGEEWIELVRWFAGEDLGKREAQRIAFQGRESANKMLRNEDLEVWLFRLLLEYGRVVDENREFIGFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZB2</accession>
    <name>A0A0B1NZB2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative benzoylformate decarboxylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004398">
        <property type="protein sequence ID" value="KHJ30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZB2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZB2"/>
    <dbReference type="HOGENOM" id="CLU_054062_0_0_1"/>
    <dbReference type="OMA" id="NMHEYFD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="28878" checksum="929E5D401E84A054" modified="2015-03-04" version="1">MTITKINSAPALDDFTPLAEHQSKTPATFYKGKPVLYFHDTQAKAIITKNHLTKLPLNGTDSYEVKHPSASSLNIVELFVCSENLTFFNPSSCIGFAIPYPAITLHAIKTLKDPEDSSQEIQGLYMQIEISDYYDHEVQEDDDSGYIDLTLIPSSSSNEGKSIIQTLFEAVSACSDLNPDPNSEDERIIDHINRDDTGIEGNVFNMGINELASIPITSFDDNLPPPFPGSGGWITADNISQYLDENGVWIGTNANSEDPMIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P030</accession>
    <name>A0A0B1P030_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fungal duf1750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002750">
        <property type="protein sequence ID" value="KHJ31593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P030"/>
    <dbReference type="STRING" id="52586.A0A0B1P030"/>
    <dbReference type="HOGENOM" id="CLU_013398_1_0_1"/>
    <dbReference type="OMA" id="WMEEVIS"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="2">
        <location>
            <begin position="258"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="55750" checksum="0F5577E4661699BF" modified="2015-03-04" version="1">MNDPSQGIQRELLPHIHLVSTYRFPQLPQIHPEKVAEWLLAAPKISREQAPFYWTYLDRPQDMTIFLVWQTMALGVEFPSDGYIWTPQETALKFQVQSGYTLEMYHHKVGYAPGEPLATHSRRRYRLLPPQVPGIQTVQPDPSLWIVHYTTAEPSERIPPNIIPIDMRVQQIMNTRQYLQSQGQIVQKDFMLHDRAQWPTIAFPRNGPQGAALNEQKIPLTRIPQTIAYPTQSPIATHPSKRIRTQPNTPGGIAVFEIDEQEDTSRGDYFDHITPREISMMRYKQNHEWMEEVISSPYSMNRIIPTDLGLGVRGELASLTNGIFDAPLDPDRDISYHNYVGRLDPEKAEEFRKRVNAKIAQTNIEIEKLKEKHLKRLKRGQKGSIFRTAEKELCQAVNNPSDMGSEVWRLEGYIEENESERVKAPLSVPPKVSDILAKVEASIECHAEPVKELLRIQEGGLEESHLIPSSQFATYSLDFPFPNRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P033</accession>
    <name>A0A0B1P033_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004642">
        <property type="protein sequence ID" value="KHJ30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P033"/>
    <dbReference type="HOGENOM" id="CLU_1332791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="206" mass="22127" checksum="8D404918FC322A40" modified="2015-03-04" version="1">MPPKGRKKTLSDVIPKAHNSRASKSVKHNSTLLSEKAITLTLAEAKAEEIDPDIIATDSEDGPSDTDIGEDPFSPPSPIRSSLSNPSLAAVQSTPAETKSPSTETRSQNLLSPTLKNGLAQSIHAKSSEGFKHRTQNLKRLPSKIAADLKAVVTRCAARVIAGLPILDELSTASKCKKLSNANSYIMMDEHTEYMENPSNKNKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C0</accession>
    <name>A0A0B1P0C0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003685">
        <property type="protein sequence ID" value="KHJ30735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0C0"/>
    <dbReference type="HOGENOM" id="CLU_004498_10_1_1"/>
    <dbReference type="OMA" id="RAVVKCC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="45560" checksum="59BA3FC26CE2DC88" modified="2015-03-04" version="1">MHETSQNKLVQLIPKLNIDYYYDDGTPLYFTQDGRIGSQFKAKKVADEFADYAKWYYLENPDAPDRTVKEFVEEFVQNHPLLTISERKWAPQATREIELWIGTSIEQASSKYLSYFMTERNLYLKGGYDRIVNWTAQPLLQDLDLIQMGQIVKEIKWGSPKVSVISQNSTFTGDAVIVTVPLGCLRQNHILFTPPLPKSIQAGINAFSYGALGKIFVEFESVFWPEENDQFIFYPTPPSCTSPFDPDSILSYATVTSNLWIMSGIKALCVQISEPLTQRVELLPCAEVCAYLEPLFKLLRTDPNNDLPKYVNADVTHWTTDPLAGFGSYSIEKVGDESKLLLEALREHKSERLQFAGEHCIEIGNGCVHGAFETGEIAARNILEGVLGISWDGMETTVRNIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0D8</accession>
    <name>A0A0B1P0D8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 60s ribosomal protein l11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002637">
        <property type="protein sequence ID" value="KHJ31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0D8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0D8"/>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="20128" checksum="32F2A70039938F38" modified="2015-03-04" version="1">MTDSKEKAENPMKELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKRNFSETGNFGFGISEHIDLGIKYDPAIGIYGMDFYACMTRPGERVAKRRRAKTHIGASHRIKRDETVKWFKTRFEGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0N2</accession>
    <name>A0A0B1P0N2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative fungal specific transcription protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004151">
        <property type="protein sequence ID" value="KHJ30481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0N2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0N2"/>
    <dbReference type="HOGENOM" id="CLU_006524_0_0_1"/>
    <dbReference type="OMA" id="IYMHEIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="707"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="862" mass="96820" checksum="D105C4A95C14C024" modified="2015-03-04" version="1">MMSNPEASIDPLLRNIAPTPSLSSYHLVSPTIPSSSVSFSRSHSYERNSPYLNSQNLQRADGPDVEISQKDNDFNNSKRSRACEACRGLKVRCEPDPNTQDDTCKRCAKANRICIVTAPSRKRRKKTDSRVAELEKKIDALTASLAAQRSGNISITQRNDIEDVNESQPIPNQLRNNSYVQSISENYSSSFKSCFDNNSGDWSCYTKAEFEPKTSTTISSKPSIDQNVKHAEMYLNQPKLPASTSAHSKVQTEPVRNWLDSTTRPTQVDEYVDLIDRGLLTSEIATNMFNDFVQDLIPIMPIVAFPPGTNSASIRKSAPILFLAILSAGSSVNYIHLQQSLTDELMKALSERIFVTKYKSIELIQALQISSLWYWPVESFDEIKFYQLRHTAAIMAIDIGIGRKNRSPKSRVTSKSGDHPLCRNPCLDPESVESRRTWLSCYLLCCSASLVLRRPNIIHWSSFTADCVEVLENSEEAFPSDRMLCQWVKIFHISEEIGTRFFMDDPGAIVSFADSQVQHTLRGFERDLEKWRASQKPENMSPNLKITEHGINLYMHEVATQVGHQIDNLKPPFTEDTITAFVEESDQAPLSSARVTALSTCLVSIDGIFETFLDLDVESILLFPAIDYAWIAYATGVLLKLYFAAATPNSELGKIINKESMKVEYYFDRLIEKLRAISGEEVYRCSTMFLHIMIMMRDWFHRQINRHRKPSHQRVTSGNQMGERSKEKIAHTTPSKNHSNFSSGNTMLQLLSEVATGNNVGQTTSNVTNNYSTSPNKWRQSSQSAYPGYPAGHFPVNQAYAQPNMNGNIDPSLKIDLEYSNVNGPQNAIFGFGDLGPFISDDAFFGGLMNSIFPPNMGFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V0</accession>
    <name>A0A0B1P0V0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004231">
        <property type="protein sequence ID" value="KHJ30449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0V0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="28615" checksum="08C6CA539536A839" modified="2015-03-04" version="1">MGGGRWSCILQVATASIREVTVKKLSVSPSLIGKIKPAHSGFALSSSKTEVRDTILKARNGLLLSGAKLEPATNWISILIPIVPSTTCLEQGQIDIYNTMIERICSVRPAHLKIYGRNDTNAPHRTWMAYFTKAPRGRFRAFDESGIARSFKKQQPLQFYICMAATKCRNCSGPHCSDSCRCLSRPTRSGAHTKEQMKVCRQMGDREDQAILRAKAAEENSASSETTILNAPSSQITEINSSADDTLASPVESSTCVAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z4</accession>
    <name>A0A0B1P0Z4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sucrose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004123">
        <property type="protein sequence ID" value="KHJ30499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z4"/>
    <dbReference type="HOGENOM" id="CLU_151460_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="93" mass="9964" checksum="C8DD409FCB717F77" modified="2015-03-04" version="1">MAYLRGDCGCSPRKSTGGVVEVFLPAKSKSSPSRGAGVNAQYALHIWDSQEDSYNPSLQEPHSSPRVSIVFVSTSPSPQHLFPRSPPRLAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P177</accession>
    <name>A0A0B1P177_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fam96b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003943">
        <property type="protein sequence ID" value="KHJ30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P177"/>
    <dbReference type="STRING" id="52586.A0A0B1P177"/>
    <dbReference type="HOGENOM" id="CLU_075876_1_0_1"/>
    <dbReference type="OMA" id="YETKEHH"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="22804" checksum="90629496A29C2623" modified="2015-03-04" version="1">MIFDNANPKILDTSELALHRERRKNKSVAEPEETVMDILLDNKFYKIDPFYTSEHPDSDSDSGSSTEPIDEQEIYDLIAPISDPEHPLSLESLGVVKLQDVHLTQVSDQLSPIVISHVLVELTPTVTHCSLATVIGLGVRVRLEQALPPSYRVEVKIKKDTHSQAEEVSKQLADKERVAAALENENLLGILKKMMKPCLDKTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1I9</accession>
    <name>A0A0B1P1I9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003655">
        <property type="protein sequence ID" value="KHJ30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1I9"/>
    <dbReference type="HOGENOM" id="CLU_060764_0_0_1"/>
    <dbReference type="OMA" id="VHELHPC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="44816" checksum="18B1FA49122AAF97" modified="2015-03-04" version="1">MDPVSVPLNLLENSQAFEPSPLANKISETERNNEADVVVLETMENIRSRESNKIRRKARRCQKTSPNFPPTENSISNSTPSAISFHDKKTSALTRIHKNLSHSVNSRRPRFPRFSELPAEIRLLIWEYTFVPRVHELHPCAKLYNERMTFRSNSSKTPAIFHVCRESRQLALKNYSLMSYEPRLTGASGKGILRFYFSPELDTLFLNSLMGLFIMFMLLEDEDEYAGVGIMKEWQKVAFDADRVQLISLLAGIAGHAPHPRLKAVFPSLKDFTIAFDYSSKGKIRFRTSVWPGENGTSLEEVVLPHLDSNNERLSGREQMWSERLEMVLRPMRHYLDLDFKDEDQGYIPTVKLANVKRKAFLRGDIRYVFRKTCTFLGIRPRGPFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1L9</accession>
    <name>A0A0B1P1L9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mfs transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003144">
        <property type="protein sequence ID" value="KHJ31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1L9"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="NAIVIMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="51719" checksum="A088742C5CF268EB" modified="2015-03-04" version="1">MLCRKIDFYVVPNVAILYLFCFIDRANVGNAKLAGFEKDLQMTGYDFNKMLTAFYISYVIFEIPGNLTCKWMGPGWFIPLSSLGFGVCSLSMAFVQNLVSASVVRFLIGAFESAMLPGIAYYLSRWYRRRELAFRLSLYIVMAPIAGAFGGLLASGILKISSVGSIHGWRLIFAVEGLITCLVAIVSLFTMTDRPETASWLTQEEKNLCYLRTKSDLVSEAEFLDKINKKKLMRGIFNPITIPTAFIFFLINITVQGFSFFTPTVVSTIYPSSSVISQQLRTVPPYLVGAFFTVLIPLLSTKFDNRIIFFILSAPLMIIGYIVFVATSINDNKIRYIATFFAASGSFCFAALCNALVSANVISDTARSGAMATTGMFGSLGGLIATWSFLPTDAPNYYIGNGLNLATSVTILLISIVLLWWMKFDNRKRNCKNLTYELSQLAVLSNKEIEELEWKHPLFRWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1U8</accession>
    <name>A0A0B1P1U8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003047">
        <property type="protein sequence ID" value="KHJ31265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1U8"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14888" checksum="12944D7BFE5EEF27" modified="2015-03-04" version="1">MSCNETDITSVNRTQIDFALTIKDKEIRQKLLNDSFNLAPLEAKLEPASNLITYRIATVPVALTKTDGRVVVDNDRVIVKTTRVTKSTPKIVRLHGKIRPGPPHHSWLAHFTREKAPRPGFRIFDKSGLAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W9</accession>
    <name>A0A0B1P1W9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gpi-anchored cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W9"/>
    <dbReference type="HOGENOM" id="CLU_292752_0_0_1"/>
    <dbReference type="OMA" id="GMQSIMS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116279" checksum="710C1DF4908BE704" modified="2015-03-04" version="1">MRTRATGHSPGGFHVLASPKRVRRQPPAPVRAPPTSTTTLERSKEQQIQACDENASASLKTRSHSNGKDADHISNLHQDISPAYLSESELQTNKSNSKDSSLRSIDSSNSARHNQIQQAKIKTVNTRDGLHKKNKSSRGISKRASKRDDYAVKDIVTVEVDSNKCSRDILPGPIQSVLGKRCRGTSSGSLTTSGFSNEVINYKRIRSNVKELNRSGLLSVQNLSSKNSLQSFDESIEENRSLNLKSGQLESIEGRTDSKISPKSLVLYRASPHNSILKFSSGNLCTEQKNDVESQLKQGMQSIMSRMNKYQYQPLPKNPYDSMAACSSTPQEHKNQGINTTRKSSISVSEADKNGFNSRTESHLLGSSSEYEKTLAEYSHGGQKRNRNDEDQLPERQRLKVDNLDKLKDRRIEVEKLFRTTAPNASYQNILRAVAEWAVHNSSTLPTEDEIFTYVESSKAPDATELFSSSDRLFPRRNHSKIRRVSRERSASLSTVRTKIPKNKNSTQNSQRYGSIPKNSCNDDGTATRRVTFKKSIENHLVESDSSKTPNEHSKPSLNIETPSTTNAQQTKSIASQSWGLVNSFKNLVSTPFKALGFGLGSNTQESLKNVTKDINFEYKPPATPVSSSRSVNSERRATKNRNSYRTPVRTPIRTTGKQSSQGINQAPTDKISSRDVVTEKRMAELQRELDLKKSERRERDSRNDTNRRRKKPTKHFEVTADYKSEVSNGAKLRQLNDQTTKTEDLFEEWPPNLDPNRQAVELAQASQFLPRGPNGEDVTTMLCSGWLISKYRDSFIREVGRRKFTPAPMRKTIFGTSAVSISTRTQNLDNCDLSNTTESKVGDTKIPNNHNQPGRSYGFQYDDDSSSDEDTTVDKHELSQSDSKGSNVEISNVTPRISMGFEKTNSLNESSNQSKSAQAADTTVRRLPTTPSTPYTPRMPSTLRNVEALSPYSSKLSTPSSEQNNTVSPSHNSEDMSLVLYEHNNNLTEYSDSCEDWSYIFDLDPQMMALDQKIIDAVEILPNDSLPCVELPAVIEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P260</accession>
    <name>A0A0B1P260_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative at hook motif-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002918">
        <property type="protein sequence ID" value="KHJ31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P260"/>
    <dbReference type="STRING" id="52586.A0A0B1P260"/>
    <dbReference type="HOGENOM" id="CLU_098825_0_0_1"/>
    <dbReference type="OMA" id="FYCCERY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25627" checksum="671A6F750C51C256" modified="2015-03-04" version="1">MEYATHQEKPAVMMLPFDLEDRHRVVFGADLDQAQLAAAIETQSSVFLDWMEYNNVNGEGRDLLYSDFPSYYTHIKVRGWRLRAKGQTMGRMPVAHPSQGEHFYLRLLLTVKRGARSYRDLYTENGIECVCPSVACRALGLLADEGEWVEFINQIKDTATGHSLRLTLASIITNSLVTSAQAIWEQFRDNFTDDCLHRLSLNRDIINPPPANWAEDQCRYDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A4</accession>
    <name>A0A0B1P2A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002100">
        <property type="protein sequence ID" value="KHJ32418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A4"/>
    <dbReference type="HOGENOM" id="CLU_070881_0_0_1"/>
    <dbReference type="OMA" id="KYCSARC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="32795" checksum="E85D02ABB87E99E1" modified="2015-03-04" version="1">MDYRTRPSKHGKIPPPFYLTAAGRNLIYCHTCGRVITPRKGHTTAHNIPPPVKYCSDRCRRNKPKLIDRQIEDAFLALLQDNLQEYTVKYKTKETHVDKDLEMGTRNSEKRYQKKGEHRKIVWCSQIQALVFRHQLDYDNKKKNDPISCKKDDQKWQSIDMENKNLDINQTQDGFSEAEKSKQGRQRAEEREMVRRVARRGVVFGFTIKDDRPQSQGKENVFTESKRSNGLSNELSNGKGLVQNGSRETIRMCEAVMAPDLIVVEPSFAKGDWGIRWREENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2K4</accession>
    <name>A0A0B1P2K4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase family m20 m25 m40 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002010">
        <property type="protein sequence ID" value="KHJ32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2K4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2K4"/>
    <dbReference type="HOGENOM" id="CLU_446325_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="612" mass="67654" checksum="4EA01899CFB7D257" modified="2015-03-04" version="1">MAKSNSNGAINGKGGFFKSPSAFPNSLSQRSQPSAAQETEPKTTHKVQQRESQVSRRDSSMNFKNIFCRAKSDNVDNCSMTPISEDVQFSDRNKGVSGGSITGFAKTMALKGSFTSKDFDESAHSNLLFSGPHAKKISLAYKNSRSSSLTSSAKPISLKIMKHPECQSSTWQAPSLNQAYPQSIKHSRLSASTLSADAIIRVESNRRSNSVRESFAKFDAILRQSQPHNNSNNLIENTNFSTPHSHHRRKSSKNVTSAEWTQKIFVLVTSGYLLQYSGSGRNDRMPEKILQLGKDSVAFASDAIPGKHWVLQVSQSMSPDGTSTPNCRSLFSRINFRAMDHRKIAKSLLLVFDNADDLESWIYTLRREIKILGGRLSDSDNTRYYQKDKPLPSPKKPCQRFILQDADGCSPNSSTLPLMGPKLAEDDIRLRSKSESEGRTLFRHHSVATIRSSIGNYSTTNSIFSLDARRLGSLNGSHNRSSFMSSGQRTMITSQSSSARSSPVLSAFDDHNSKCQTDETTFFKPTPDFIHENGKGSPSETDKLPESVYCAFQGSQVPEHRRSLPTLVNEPPSLPPPRCALPPIPPRNIVKRSRGHSEISSMNFRAVSGGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P332</accession>
    <name>A0A0B1P332_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tbc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003006">
        <property type="protein sequence ID" value="KHJ31306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P332"/>
    <dbReference type="STRING" id="52586.A0A0B1P332"/>
    <dbReference type="HOGENOM" id="CLU_005350_3_3_1"/>
    <dbReference type="OMA" id="TDEWPTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000050">
        <property type="entry name" value="GTPase activating protein (Gyp3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="482"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="823" mass="93234" checksum="66DDFB6D157842EE" modified="2015-03-04" version="1">MAYPFSGSTYGKAYFSTKPQLHLDLQAGHQQISPNLDTGTQVRANLKHSLKQFSPTGLSALQTALPPSFTDHLVSQRHNVSSRSNTNMGRNSIWHRKNSEASRIKSLNHESQNHCHNSDDCYTHEKNEVVTENFSRPRQASLMGRKEVVQPNNMNNLVSLELSKNNEGRISSDSLKSRDRGLSADSLHTAATAIISAPRPLTSIPDYQIPDTNHSKQRNLIGTIYRPSRSFTKLDYYNSTTEPNSFVFRDPLPSRNVTEGEIIRSSFRSAITSNSSYLGTSGTERSSVLTKSSSRTSIFGRDEGMSVDDAIEMYEQGFTDSGGDENSINRPYTGSSEKNITLEFKPDMKDFIVLSPSDKIISDKSAEIFDTYEIDTYELPIRQETSIPNKETDLGHEASPSRPVTRSATTQFDDTRDRYGFRKKTQHISLEEYGAWNKQYTAYLARRKKKWIALMRQYNLPTIDPKDFPPRSDKIKRYIRKGIPPSWRGEAWFHYAGGPAMLAKYPGVYDDLVRRSFLGDMKQIDDEIIERDLNRTFPDNIKFKPDRDPNATSPEEENFETPILQSLRYVLRAFSIYHPRIGYCQSLNFLAGLLLLFMNEEKAFWMLNIITRIFLPGTHSLTLEGANIDLGVLMSSVKDMMPSIWAKIGNELDGQPSITTVSAPMRLPPVTLCTTAWFMSCFIGTLPIETTLRVWDSFFYEGSKTLFRIALTIFKLGEPQIRAVTDPMEIFQVVQSIPRGMIDCNLLLETCFKRRGGFVKLSQEDIERGREERRRCYAEERERIALGANMATSGAPKSKGGTKRGNTLFGRGKKERVGLPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P358</accession>
    <name>A0A0B1P358_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fe superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002611">
        <property type="protein sequence ID" value="KHJ31750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P358"/>
    <dbReference type="STRING" id="52586.A0A0B1P358"/>
    <dbReference type="HOGENOM" id="CLU_057349_1_0_1"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="289" mass="32944" checksum="63672F767E174267" modified="2015-03-04" version="1">MIRQRFPKRKLVSRIFSRSAVSVPLLPQLSGLNHIPQFLSRVAFEISWNHYQSYSLENLQRLLKVSDCSSKNPKDIAIQYARDPTNASIFNYASFAHNNHFFFESIDEGTTSPESMNEKLRLQLIKSFGSIETLKSEMLFTASAMFGPGFVWLVKDFENNYFVLATYLAGSPYPQANFRQQPADLKNISPEKAPEVMSDALRNKYTGQAMNSVGRFGKLSKGPRIPCGGPETLVPILCVNVWQHVFLPDYGIRPSINGGKPRYLENWWKKINWKVVSQRAIGQNLSWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X7</accession>
    <name>A0A0B1P3X7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01002708">
        <property type="protein sequence ID" value="KHJ31641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P3X7"/>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="OMA" id="PPCVDEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1036"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1065"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1335" mass="150616" checksum="CACCAC3A8304ECDB" modified="2015-03-04" version="1">MGVETSPRTVHFSDTETKKNKDSSQPKASNQCNDVELLEKFPELGTVPTDGAIAVQSVTHPSIDQRLNPHNIQSCLRGHKGSTSSNESLTISENPFSPAPISYSSSNPRPQRPIGPARAPSSTYAPTRGPPPSSFTTVAERKRSGSGARLRPDPNASYRAQEKAYVQRLWQDQQAEYSEPYTPSLSHGSDSDDVNSSSDPLAESFDQETLLFYGNDNNKPTEDDLKDPICRERLEWHGMLASVLTGDVVRQEKKRLIGASNKQVGNIYTDIWLELRAKACGRTTFSQKRIIEEARKGINTHLQEILSFEVKLGNETGKSPIEQVQDIFKKIEKCEVLYPSRAAFKSANKLAASPEFNTACEVIISWHTTTELINTELKILQSWVGNSDLDFNRTKERPLLVNGLTDESTFIDRLLKEDGLRSLQEEKSILNAVSKVIMKAKATLIENSHAFGKINLPLYINELLILINFPSRLIEEIIKVRLQFSKKMKDPTQQNLMMQEQMISQFQILLKLAIRIKQENLFISQTEEGWNLPPCIDDTFDQVVLDALRFYLKLLSWKLGGNKNTFKEAEVLEQEWKFSNEIGRHLQGGDVEVAEQFTSLTHKAFLRLHTTFERDLKRKPKETAAEVTKRYKQNLDSVRVRQRMLQRFSRDLSERFENATDFSISIGRVELEQLYASLAATNHFLVYTASIEHDGIFLVASPSLYNRQGDIQSILGTCFRPNEFSEDSRNPYILVLRPEHPIVWDGQRVDANIRDPTTDVKVGHLRLITDGSRARLKSARTAFLESIDMHLDMVVEQRSNLKKVNMKLTEIKKVVYKLSNLIMDSVEIVRKQTEGMDCQELIQACFVFATEFGQRSMPYMDQNRKQMNNIKLTKLALDWVSFVSDDCIASDRKTFRWAVLALEFAMVMTQGQNILSLGDDEFIRLRAKVAGCVSLLISHFDIMGARSTLAAQAEKQRVEALAVQLRKVDLSRMVDDEESSRYVTEQRMIQLADIDNIRKQREAERQALGRVMEDSSEADRSLTYLSSSATNVNMRWQQGQFVGGGTFGTVYAAINLDSGQLMAVKEIRLQDPSMIPTIACQIRDEMNVLEVLDHPNVVSYYGIEVHRDKVYIFMEFCSGGSLTGLLEHGRIEDEQVIMVYALQLLEGLAYLHESGIVHRDIKPENILLNHNGVIKYVDFGAAKVIARQGKTMIVADAAGAKPNKSMTGTPMYMSPEVIKGEIPGRAGAVDIWSLGCVILEMATGRRPWSSLDNEWAIMYNIAQGNPPQLPNPDQLSPRGIDFIKRCFIRDPRTRASAPELLQHEWITAIKSQLSIEPGTPSESGSINFNVSRGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P459</accession>
    <name>A0A0B1P459_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="JNVN01002325">
        <property type="protein sequence ID" value="KHJ32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P459"/>
    <dbReference type="STRING" id="52586.A0A0B1P459"/>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="112"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="614" mass="69843" checksum="13CEB9812206B399" modified="2015-03-04" version="1">MTSVSGHLTEARFPDDYKNWEYPPPESLFDAPVRVVIDASKKSIATNITQNSRGAKVLFIWTDCDREGEHIGGEIRTEALKGNANLLIWRARFSNIERAHVIQAAKNPTVLDDRQVDAVSARIEIDLRIGLAFTRYLTLTLRPLGEALSRSPDGKNRVISYGSCQFPTLGFVVDRYFRVRNFVPEKFWSIKVTHHRDNTDVIFKWKRNRLFRREVVVILYERCLAAKTAKVVKVQEKPTSKWKPLPLTTVEFQKMASRFLQMNGQEAMNYAEALYQKGFISYPRTETDRFDSAFNLRALVEKQVQDSRWGSYSQGLLNGAFVQPRQGRNDDKAHPPIHPVTWVSPSSLTPQEARVYEFIARRFLACCSDDAKGQATNIEIEYGEEIFDAHGVVVLARNYLDVYPYEKWNSTTILPKFTMGEIFQPTEAMITEGKTTAPGYLTEPDLISLMDANGIGTDATMAEHIAKIKERGYVFTRPRGVNNSGMNDENEIQTRANGRGRGRGRGRGGRGGRGSRGENTSNSTRNSGVEEFIPSTLGVALVDGYDRMGFETSLSKPFLRKEMELRMKDICEGRITRDAVLLDNIRQYRRVYEQSRERVDILKASCRRFVLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P1</accession>
    <name>A0A0B1P4P1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g3043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002493">
        <property type="protein sequence ID" value="KHJ31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P1"/>
    <dbReference type="HOGENOM" id="CLU_055356_3_1_1"/>
    <dbReference type="OMA" id="ETYYCFN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="215" mass="24117" checksum="5B9A8B077BC4D855" modified="2015-03-04" version="1">MADGRINQQVARKYWQGIKADNGGMLGGYGYISNIDIRGSRSFIQKLNITDNRAKLSRAVDCGAGIGRITKNLLLELATTVDIVEPIAKFSNALQGTLGIGDIFKNGLEDWSPTESYNLIWNQWCLGYLNDTQLIAYFKQCARFLKPDGLIIVKENISSSQLDIFDEIDSSVTRTDEKFLHIFDQSGLKVKKAEIQKGFPKELYPVKMYALLPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V5</accession>
    <name>A0A0B1P4V5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002642">
        <property type="protein sequence ID" value="KHJ31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V5"/>
    <dbReference type="HOGENOM" id="CLU_1001073_0_0_1"/>
    <dbReference type="OMA" id="HASWLTF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="285" mass="31510" checksum="C7C0157706E0BB1C" modified="2015-03-04" version="1">MASQKLSPTNTAQLSGTGPSFDAALRRDYQNVDFAARSGRGEENLPIPLPTDDIRVAMNKLRALADVVSKGKSVAIYTSYKGTPSVERDPVNIAKASMTDAQKEQYEAWASGYTMPTYDWVNNTKPLKGGERTRIKLERRVEATREIWGNNSITPQNVYWLAEHDPFIMPLITAVAKVNSARRNLAGRQEHLMEYELAEVQTIHNAIKTVTATQNAIMAELNLVNRSINEAKKVLQAREDSIKTKNPVNIRRERAGLPSIGAGVDFGAGTRGGRFARKYFSADTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P547</accession>
    <name>A0A0B1P547_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dna helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002365">
        <property type="protein sequence ID" value="KHJ32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P547"/>
    <dbReference type="STRING" id="52586.A0A0B1P547"/>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="OMA" id="EHAHIAG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="201"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="50711" checksum="27B7D6488BB59CEF" modified="2015-03-04" version="1">MVKRQKRVLVCGPSNISVDNIVERLVPSKIPIVRLGHPARLLPSVLSTSLDVLLQSSNAAAIVKDIQKEMDSKQTSIRKTKSGKERKQIYADLKELRKEYKNREKNVVTSLLGNCKVVLATLHGAGAFNMRSEVFDAVIIDEASQALEAQCWVPLLSAQKVILAGDHLQLPPTVKSLNSRIKIKGTVDAEDKPKIIKGMTLERTLFSRLLELHGPKIKCMLTTQYRMNEKIMRFPSDELYESKLIAAEAVKNCLLKDLPYEVQETEDTIEPLIFFDTQGGDFPERNEEEILIAVEEKNSGNKNMSKKSGGIIGESKSNEMEAALAKFHVQKLVDAGVKTEDIAVITPYNAQLTLLNQSMKDLFPGIEMGSVDGFQGREKEAVIISLVRSNSKREVGFLGDKRRINVAMTRPKRLLTVIGDSETLRNDKFFQRWIDFLEENSDLRYPSVSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P571</accession>
    <name>A0A0B1P571_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002349">
        <property type="protein sequence ID" value="KHJ32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P571"/>
    <dbReference type="STRING" id="52586.A0A0B1P571"/>
    <dbReference type="HOGENOM" id="CLU_515053_0_0_1"/>
    <dbReference type="OrthoDB" id="5404940at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="59820" checksum="967EE39729ECF853" modified="2015-03-04" version="1">MGIPAPFLYDTAPNSKESHNSYGQLDTKFIFKTSSGPRASQVAERSVTVDPSDSYYFEPKKKINAYHMSNSVKKFINLSRKWLFVLSSCEVLGASLLFITGIIANPIESSTAWIIRLTPMFAMTHSAYAIYYLSCKKTARAKAFSAYCYFFACLDAITIPLYIYSMLFYAARPIDSRTVVSDNLNINFMLCYEIGMYCADSLSVLYLFSIAVSLYMGRVYRKIAAMPPDMNPLEDNLTSRHKRNKSSIMNTDPIPKNQGLIMFEPKKGLRLKSQPVSRQSAGSFVAAKFETSHPILDSFSSLGKSCEHQLAENSPYQMSYSEMKRSVGIAPNIKNMLENMDQSQHESNSNPWYSKDSLSRRHKYKRSVSPKKYPDQYAMLVHKNEPTNDYPNFKPNSLLSPNNMLNRYSVSSLASESESISNTDLSSIFSMDSVDIGDLSLEPSIKKTALRPRVDSPWYEDLSLSNPPLKKVRNGMRQLSSGHDYVLGEWNSRGMNGLKDLKGKNKSEKRGEDRLSGVRIRRFSGKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P599</accession>
    <name>A0A0B1P599_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosomal rna-processing protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002009">
        <property type="protein sequence ID" value="KHJ32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P599"/>
    <dbReference type="STRING" id="52586.A0A0B1P599"/>
    <dbReference type="HOGENOM" id="CLU_058264_1_2_1"/>
    <dbReference type="OMA" id="KTSENYH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="32605" checksum="78550CBD7EAD8907" modified="2015-03-04" version="1">MSKPLEEAVPLPNKSRKDESDTQDCRLTKKRKKTSENYHLSEDDNSERTKTEKTLIALSNSETPKTPKIPDFSSDDESQDKNRSSPEFNDTSNSDSESNASNSSSSIKSLKLNGQKKRKRNDPEIFATSMSKILSSKLSSLKRNDPVLARSAQAIYISKQATDAKLESLAKRKIRADKKDALKKGRVVDVLGTNLASENSVTSNKETTKNSSQSIMEKERKLKKIAQRGVIKLFNAVRAAQIKGEEAAREAKAIGIVSQKNKEEKINEMSKKGFLDLIVKRGEQTKLEAIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M7</accession>
    <name>A0A0B1P5M7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001930">
        <property type="protein sequence ID" value="KHJ32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M7"/>
    <dbReference type="HOGENOM" id="CLU_088285_2_0_1"/>
    <dbReference type="OMA" id="FYVCPAH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19993" checksum="93DBE3D947980267" modified="2015-03-04" version="1">MASFPNIYTHRKVAETAAKSCEICFKPSTSVLLASGHKDFFYVCQVHLKDKKFCKPLTVQINTATQKKWEIGDEIARLKKEYEVKQSMKNNKGEDAPKLKEKVDLEIIDDKSSNKKKDSNPITVESNEPKEFSLTNIFYQQRIEKKKNAEIAKQRSERFQNPNLFPKVPKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N7</accession>
    <name>A0A0B1P5N7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001916">
        <property type="protein sequence ID" value="KHJ32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5N7"/>
    <dbReference type="HOGENOM" id="CLU_008020_1_1_1"/>
    <dbReference type="OMA" id="WAGMIRV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="343"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="693" mass="77758" checksum="22BEFB45F71ECED1" modified="2015-03-04" version="1">MRKWIWALYFTVNLSGFFCPALTISTFSPVKPPAIPLAVNSPYLNVLLADGGKEGGGYLARKWPNFWTGHTVGWAGMIRVDGIVYTWMGIPGPQPMTQTAFEYTSTKSIFTFNAEDKVELQATFLSPVTPDDLKRQSLTSTYLNVAIRSLDGAAHDVQLYTDISAEWISGDNNSVAQWNFGRTDDNISYHKVFRQTQLLFSEVADQAEWGSWYWATRDMVGLTHQSGADEVVRNTFINTGKLENSQDVNYRPIRQNYPVFGFSLDLGSVIESKNTLFTINLGQELAMQYATTSGKVQLPSLWRSYFPIYENAVSFFYNDFDYASSTATNIDNQIATDSITAGGQDYLTITSLSLRQAFGATQLVGDKSKQYLFMKEISSDGNTQTVDVIYPFYPIIMYLQPSLAKLLLDPLFETQESGLYPKKSSMHDLGSHFPNATGYPDGLDEPQPLEECGNMLIMTLAYSKRANDTSYLDQHYQILKQWTEYLVEFALIPDDQLSTDDFAGHLANQTNLALKGIIGIRAMAEISNLTGHDTDGLNYTSIAQDFISKWQTYGVAQESSPPRATLAYGLNDTYVLLYNLYADSLLNLNFVPKYIYDMQSAFYTTAKENYGIPLDSRHKFTKSDWQIWVASISNDDTKNTIISDLARYIRETPTDSGFTDLYDTTTADWAANITHFNSRPVVGGHFALLALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q2</accession>
    <name>A0A0B1P5Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative translation initiation factor 4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002417">
        <property type="protein sequence ID" value="KHJ31999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Q2"/>
    <dbReference type="HOGENOM" id="CLU_043552_5_0_1"/>
    <dbReference type="OMA" id="LPLQYHW"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000016">
        <property type="entry name" value="Translation initiation factor eIF4E, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="239" mass="27405" checksum="09DC491CA12A917D" modified="2015-03-04" version="1">MALRAATRSMVLPTRGSTNSLNGSALEQRDDAKKNMLKAMRPLPTQHYWNIYFDRQQKDPAKASEVSYTASLEQIGSQIESVQDFWRYNNNTPVEQIKMRESIYLFKQGFRPIWEDRRNINGGSWTFRVPKSNGPDFWTRVQLMAIGEKLQCCLEPGDQLCGVGLSVRFNSHLISIWHRDASKEKSIEAILRLVLDELPAELQPKVDNYFYKKHSDHASFRAPATTSKEILPSKIQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Y5</accession>
    <name>A0A0B1P5Y5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001046">
        <property type="protein sequence ID" value="KHJ34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Y5"/>
    <dbReference type="HOGENOM" id="CLU_096870_0_0_1"/>
    <dbReference type="OMA" id="FYWVLDT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061894" description="VanZ-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18004" checksum="1C5A96EE104267FB" modified="2015-03-04" version="1">MRIRLPFAGSFIFLLAITGYASLSTHQPRDIVSNEPLHAITFFILTTCFYWILDTSRRRSFNFTILTCTGILGVGFEFLQSLLSNGHSLDLYQVLANLIGSLTALTLCSWYHTRMLGRKRLAKQYKVVATDDLELEAAVGSEPQHPEIVNQGAEVQGHNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Y8</accession>
    <name>A0A0B1P5Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative importin-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002338">
        <property type="protein sequence ID" value="KHJ32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Y8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Y8"/>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114918" checksum="76A047DCE9306C79" modified="2015-03-04" version="1">MAATTEDQLLSVITDTQSANEIIRKQAEQHLSRAERNPAYPVSLMAIASHSNVTLENRQSALLLTRTWVEKYWNPTDQEGATSLDLVILNDVSKEQMRNTMLKLATSEESDRKIRNVASYVVTKIAINDFPHQWPNLLSTILHLIPNASDQQLNGPLKVLSDLVEDVLTEEQFFLVARDILKVVYDVAISEDRKPVLRALAIAILRGTFDIMDMVKQEHGPEVKRFADEALKSWLPLFLGIIKAPLPLRNTGDGNDCRRGIIALKLQVVKTLMKIRSVFPKLLLPQTLVFFSATWAELNLFKEEYQFMYVENEEQGRLEDADGLPYTLDFLVLEELDFLQSCLKAPPVQKELEHQLQQFSKISESVWVLDVMKLAVYYAQITKEEEDLWDIDVNLFLAEEISATTNYTARTACGDFLIKLGEWLHQAALEGLLIFSQLLFSASDSTWRMRESALYLLTQLLNDFIDVGEKVTPEIIGVCFGLIEYAISRTDEPLLRARGYLVAGIVVQSIPDMSLDLLSRTIKSINSDESEVVKVSCIKSIQGWVKDRSVAEHQLPIINAVSEYLYSKDLTELADADDLLVTLVETLRASINIDPCISVGDSPVLDLLFQLAKHGAANFQMTMLVTETFEDIVKKFSGTDLFTQLCLKVLPSLTGAFDIGNMTGDSPLVELATELLAALTQNGSEPLPPGYVAASLPKLSCLLMATSEGGILRAGAETVKFMLMHDHQQVFAWYDEQNKSGLEVCLIIIDKLLNPSVEDNAASEVGGLAAELVEKAGRERLGPFLEQLLRAVASRLATAEAPSFIQSLILVFARLSLTGERDVVDFLSQIEINGLNGLQVVMSKWLENSINFAGYDEIRQNVIALSKLYSLNDPRLAQIMVRGDQILPASDAILTRSRAKTNPVKYTIVPAPLKILKVLIEEFLSASGHLNKVSLGAIAADDEDEEKDEWEDIPNSLDLSNPSIKADLMTFAEANYTRQPDDETQAFLIEFFLRAFRENIGDFSNWYTALKAEEQIKLKEIAQEAGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P665</accession>
    <name>A0A0B1P665_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001811">
        <property type="protein sequence ID" value="KHJ32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P665"/>
    <dbReference type="HOGENOM" id="CLU_096592_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="104"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21545" checksum="BE8BF81D89B9FFA3" modified="2015-03-04" version="1">MHSEDVCMAATKCRNFEGPHRSDSRRCLARPTRFGAPTKEQLKIYRQLREREFQVEARAREAELKAAGTKEPTSVEPMNLVDNNACQEIDVSPVEAPTGDAMHRIVITGDFNSVHWAWQLGATHSYGQGEEIKKWAEDHNFACLIIGEAIHRAGDTLDLDFTNITEACAWVDHNECMNSDHLPISGVVPCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P686</accession>
    <name>A0A0B1P686_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001796">
        <property type="protein sequence ID" value="KHJ32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P686"/>
    <dbReference type="HOGENOM" id="CLU_1185787_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="234" mass="26158" checksum="DFFB0911DA97FAAB" modified="2015-03-04" version="1">MFIANTVVYCTRNYTISKIGFILVILPIYIIVVPVKSESTPSRGAGVKAQYTLHVWDSQEVSHNPSLQCNGKWTTLIKIVHNDTFDIKGNILHYSSTECKRVTRSVSASDIYGMISSFDLGSALITTLKAVTKSLSIKSIPLIIYTDSFSLYQCLTKQGILIEKRIMIDVMSLRQSYERREIEEFRWINGADNPADAMNKSSPNKALTNSIDSNTLSIRIDGSVDRPSFSDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P699</accession>
    <name>A0A0B1P699_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002060">
        <property type="protein sequence ID" value="KHJ32471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P699"/>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="OMA" id="TFPVEMK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="707"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="957"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1489" mass="169702" checksum="A005C7793A33237D" modified="2015-03-04" version="1">MAAGKKKKKPLSNPARGFSTTSIASKPKAVLPYSPEIELSNKLVTNNVNSNSNPNLRPETVETPEEVRNVTAEEFEKSLEESELQMLVEKYAEKSKKEVKRQILRLETDQRILRCQAEVLHTKKWLSTDLMNEILQLIKAEGRFSGYGNTSNSAKQASEETLTIYLWNLQQVLVDSGFLQEKVLLCLRHILCISDRIRVTSKDMIWGLEEALDWLSRECIKEELPDYEKCNRQTGAYSKTSCDKTLDFQNYPALNPKIDLGNEYKGDKKDIKVEKIKQESPIKELVSVDYESDIDPDDLLKVYLECKTKLYNLEISKSSKQHMPEDNLNQSLDSGGDKLENPQSDQLLRKLKKIEDDVLFDKYIASQHWGIKRVQLQKETARLRYSKSSHEINHCSAAPKFLESSEQLKHGTDTSKSLTEPYHKVNKEAALFGDSILQEGDSDDNETILTDLFSSRPAKENESGTGNTITAINGNDEVKVVIRDFGEWTGINPSRLLEEFCCARDSSVKLHYKLESEQSFSSRHSLQIFWSKTLQIKSQPPATIDFSSSPRCQTFTMRGISTSNSKQSKAFIATTALYYLFGSSKEIKCFQRLPSPWKDLWTEYSEHDKGLIDEACRANIRIFRDMVRDKRDQELEDGVLIQGAFKNRNVSRIIENEESCTDDANRLNVVKETHQRLWHEKSSSHNYQTMLSSRMQLPMWEFKEKVLSTIEREQTVIICGETGCGKSTQVPSFILEHQLSKGKPCKIYVTEPRRLSAISLARRVSEELGEARGDCGTNRSLVGYAIRLESNISNETCLVYATTGIVMRMLENSNDLKNITHIILDEVHERTIDSDFLLIVLKKLLTRRTDLKVILMSATVDAERFSKYLDGAPVLNVPGRTFPVQVKYLEDAVELTGYSLDNGKQENFADLDEYLDIPDSNVTNLSKIEVTKALKGYSNRTRNTIAQIDEYRIDFELVVQLLLKIATNDRLEAFSKAILVFLPGIGEIRQLNDMLGSHPFFLSNWYIYALHSTLANEDQESAFLLPPSGTRKIILATNIAETGITIPDITCVIDTGKHREMRFDERRQFSRLLETFVSKANAKQRRGRAGRVQEGLCFHMFTKYRHDNIMAEQQTPEFLRLSLQDLAIRVKICKLGSIEETLSQAMDPPLAKNVRRAIDALIDVRALTTGEDLTPLGIQLARLPLDVFLGKLVLFGSVFKCLDASITIAAILSSKSPFSAPFGSRSQADQIRLGFRRGDSDLLTVYNAYLAWKRVCMNSSLSEYQFCRKNFLSQQTLATIEDLKCQLIVSLVDSGFLPLTEAEQSNLNRTRFYGRGRKFFDIPKRSNLNSDNDVITTSIITWSFYPRLLVQDGKGYRNCANNKTISIHPSSVNKGRNDIKWLSYYHVMQAKQFYNAHETTIAEQFSIALLCGDARCDMYAGVISLDGNRARFAVSDWKTLLAIKTLRYRLREILNKSFKNPGKPLSAQQQKWMEIWQKIFTQRSMTEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H7</accession>
    <name>A0A0B1P6H7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6H7"/>
    <dbReference type="HOGENOM" id="CLU_370538_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="751" mass="84157" checksum="A88D8B6D9973FA6B" modified="2015-03-04" version="1">MYLTPRSQMNYSYTTNPASSAEFTRSFDSPNCQKKHLSLDFDTASTLFLPSTYYGLNTTVSENTTLISSNDRQTSPTNGYEKIELPVMNNLKHTASYSSDNLKKLSVCSSSSAVDSVKPELLEKLDENSKITSMHGGNSGFSLLNPIFLLARLRTPQHALQFLAKEKVSIARETTGQYDEFCYSTRGVLAYDSDIFGPLAASCMLLISRGCDESCCSTSSPKSLCTDKSPESSISEYNSSPASTEDPCEKRGLEPDFLCWENDSLTDFVLTEPESFQAVPKAFESYSSPIKIEKSMRMQVRQNPSIQSGAVFQFHSPEGKVSKIKANHIQSLEAALSTEDKSKCKDASIFISGSESTRLTQVTKTLKEICKNSRGNNISDFDSITCVKEQIFDLPLILTPMIYNLMPFITKNYNLTSQNDKYFYKETYFNEIKKQQCDRSPTKCPSMESISRHAIPTGQLSNNIISKRRTKPNLIQNFNNEILVSPNSNTKYSNMENLQQLNKLTADSLAAHQRALDFAAFDAENNAKIYQNNVVSDGYLQFEQENSQPSLSNDSFETSSQELTSLLDEYINDFDFNDDSQDIAFIEAVNAEALANDFDGFYGQEFGLYSTELIGKDFGCKNTGNPRSTGSRRTRSSWDSRFVSHEPILSPITECSEYSYYSQCKSPVQQSPSSFREIKSPGLEQFSCERLIENFESINNFDSLLISRRNLSGENQKSVQNFSNCSHWSSDSEEGSVDSNSPQSYGEFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K1</accession>
    <name>A0A0B1P6K1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001162">
        <property type="protein sequence ID" value="KHJ33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K1"/>
    <dbReference type="HOGENOM" id="CLU_037043_1_0_1"/>
    <dbReference type="OMA" id="GCDLWTV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="283" mass="31973" checksum="262B5B0B841ED50B" modified="2015-03-04" version="1">MKFVPLFDEVTSVLNFSTLDCRVIGGCDLYTTKAAGSDKKLYRNIECSLESQYVSLLKYSASIIPPREGLSPKTLSQPSPFGPLSQISSRRTFAYLIAILNASHSDYDFSEILSPADFRRERSLKSVINVIDSNLNALKPVSSVNIQNLSQGGFSATSSTSLTRSWGPGMWGIINKEMVLKDCTIYCWLPPDELFDGDERSIWSMNYFFFNKDLKRVTYLHVRAIPAITHGPRECVETFKLSLSRQQSGANKRARFWLGDKADNVIYEEATELDEDEEIWTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N7</accession>
    <name>A0A0B1P6N7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01001666">
        <property type="protein sequence ID" value="KHJ33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N7"/>
    <dbReference type="HOGENOM" id="CLU_028288_1_0_1"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="466" mass="53895" checksum="DA4913A7ACF05B19" modified="2015-03-04" version="1">MEGIERESNLNRGPCLEKKTNLEDLFPDGESDDEFQSEKDNQDAKELPTAHNSQTLDPEVIRSYYQRLFPWRYLFQWLNHSPVPSNDFGHREFAFTLPNDAYLRYQSFPTSDVIRKDVLRLNPSRFEIGPVYSTNPRDRKSLTKTSSFKPISKELCFDIDLTDYDDIRTCCSKVSICQKCWQFITMAIKVIDVALREDFGFRHILWVYSGRRGAHAWVCDKRARNLNDQKRKAIAGYLMVIKGGIQSGKRVDLKRPLHPHVTRSLNVLKAHFKVDILQDQDPWESDEKFGRLLELLPDQTLKNALLKKWSSSPGRTSVAKWADIDNLAKAGASKNLDATALLEAKQDIVLEYTYPRLDIEVTKHLNHLLKSPFVVHPGTGRVCVPINAKKCEEFDPLSVPTVLDLLREIDEWKKEEISDEKANQDWNKTRLKPYIEYFRSFVISLLKDEKDTIVKTEGDNNKALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P711</accession>
    <name>A0A0B1P711_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gtp-binding protein obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P711"/>
    <dbReference type="STRING" id="52586.A0A0B1P711"/>
    <dbReference type="HOGENOM" id="CLU_011747_2_6_1"/>
    <dbReference type="OMA" id="PRVGHWE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="157"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="386"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="638" mass="70513" checksum="8B66AF2121E1FD66" modified="2015-03-04" version="1">MGAAAAIVLSFNFRFNDFAFGSAIDFRYNPSLESSVLSSDETLVILNLSLDKKAVISRYCYKCLGALHGHDFILESRWVKCKMQPRLRRTHGILMPFLYPCLFNANNLTRSVSPNVYRRQRRFFSANISTTSGIEISQLVDEEQQYHNKLPDDYSRTVFSDRATITVYAGSGGHGCVSFLREKYINEGPPNGGDGGTGGNIYIQAVWGETSLHKLARRNILRAGRGKNGQGKMKGGERGKDVVIKVPVGTVIREIERIDPAALDDQETKLISTLHNFDNNESGIVPSPNREKWILYPTLKSKDISSAKFPRLPRGRKSALAAMQIKAPIILDLKNPTETPLLIAAGAVGGLGNPHFVSQSLPMPKCATKGDEGQRIMLELELKLLADIGLVGLPNAGKSTLLRALSGSKARVGHWAFTTLQPNIGTAVLDDHKNRPIIQATLENGEPRTNFTIADIPGLVKDAHLDRGLGVSFLRHVERARVLAFVIDLSAGDAILALKSLWKELRMYELMKIEEAQEKAILQAHWSPFKTPEDALANHQETIIRCTGPNFENPLAPQQTFIGEKPWLVVATKADLPETEQNYIRLKDYLKGVSDGLEEHPSQQKKFWAGTVMAIPVSAISNEGTEKVTKCMAELLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P753</accession>
    <name>A0A0B1P753_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002035">
        <property type="protein sequence ID" value="KHJ32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P753"/>
    <dbReference type="STRING" id="52586.A0A0B1P753"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="246"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="558" mass="62144" checksum="C8B8177641D78444" modified="2015-03-04" version="1">MASSEKPTIPENSSAAVSKKGAKKAEAKAKKEAEKARKAAEREATAASEINISNEDTAKQNYGPISNSTKTASKLIHLRDLTEDYVGSTFKLRAWIQNARMQGAKMAFLELREEGSWTVQGVVAANNEGTVSKQMVKWIGGLKLESFVQVEAEVKKPLEPVKSCKVSEIELHLTKLYLVAPAPEMLGLGLAVANRAVGRLDEEETTETNLEGMSLNDAIPLASLATHLNNPAMHKRAPVSQAIADIRIAVEDLFCEYLRARRFKRFHPPSLIGAASEGGANVFRLPYFEKEAYLAQSPQFYKQFEIAGGRKRVFCVSPVFRAENSNTPRHLTEFTGLDLEMEIEEHYHEILEILEGVFLHIFKELSTRYREEIELVRSIYPSEELLLPEPGKEVRLTFAEGQALLRAEGPEEFRNVTDDEDMSTSQEKALGALVRKKYKTDFYVLDKFPTAARPFYAMPDPENPAVTNAYDFMIRGQEILSGGQRIHLPGELEASIRSKGLDPNQPGIKEYVDIFKSVGVPPHGGGGIGLDRVVAWYLNLPSVHLTCDYPRTPKRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7G6</accession>
    <name>A0A0B1P7G6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative calcium binding modulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001776">
        <property type="protein sequence ID" value="KHJ32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7G6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7G6"/>
    <dbReference type="HOGENOM" id="CLU_051357_0_1_1"/>
    <dbReference type="OMA" id="QFIVTCI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="27852" checksum="18EE0CA71CDBEEB2" modified="2015-03-04" version="1">MAYNKVFNPDKLPSFAEPERRVSAPTTQADLSSYMNKPPPPLPQSKPMKQSLNYRYSQTSRPPVSPTETEVADRRVLWELYQAVDKNGNCLLSEKELRQALVNGDWTLFDPYTVKMMIRLFDTNQNGGINFEEFCGLWSFLGSWRSIFDRFDSDKSGNISINEYANALIAFGYRLSDKFVYMLFKKYDKRGVGAISFDLFVQSCISLKRMTNVFKKYDDDRDGYITLSFEDFLTEVIEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7H0</accession>
    <name>A0A0B1P7H0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000995">
        <property type="protein sequence ID" value="KHJ34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7H0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7H0"/>
    <dbReference type="HOGENOM" id="CLU_030894_4_3_1"/>
    <dbReference type="OMA" id="WIYKWTR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="18105" checksum="70C949758012BF81" modified="2015-03-04" version="1">MVYKMRIYVDGVCRGNGRPGSIGAAAAVFELPHGRQTTYSCILPSRPTPTNQRAEITAIIIALEEALERYERLRMAPYLDVTIHSDSRYAIGCMRVWVQKWCQNGWINAAGRAVANKDLIQKANRLDDKLRDLGSVEYVWVPREENVDADEACNDALDSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7J9</accession>
    <name>A0A0B1P7J9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative miz zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000984">
        <property type="protein sequence ID" value="KHJ34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7J9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7J9"/>
    <dbReference type="HOGENOM" id="CLU_034312_1_0_1"/>
    <dbReference type="OMA" id="IIVQDET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="442" mass="50794" checksum="42AAFCDA704D3BF7" modified="2015-03-04" version="1">MTNNNSHLISHVSPISVQTTLYDQPHSSKIKDDINLYHQTGILNRNIVPPLNWVHPASMMGVKRPELNALHQAHLRSPYLVPAVLLPRTKKENSVFKYYQAIKDFALYPSILSLCSILNFEFSVSEAEIIKIPLDSISCNGSICSREFQQGTLQYRLRCVEISSSETSILGNEWMVKDTTWPENICLDINSRHLEIRRKIHHGKDLPIDITQHVLKNGIDSPNRVTVSIIQDRNKVEVHNYFLAVEVIEILEHSQILDMCQKTNRLPVSHTLEMIKKSLAPSLIDKDDGFEMVISHISINLADPFTTRTFEIPVRGKYCLHRECFDLETYLNTRISKPNRKNQPCMVDVWKCPLCGNDARPWQLQIDGYLESIRTELVEQGNLDVVKSIRVEPDGKWYPKIEKRKSFTSSIEQNSLNNDSNTSLQESLKFKRPIEVIVLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y7</accession>
    <name>A0A0B1P7Y7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001639">
        <property type="protein sequence ID" value="KHJ33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y7"/>
    <dbReference type="HOGENOM" id="CLU_532308_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="512" mass="58902" checksum="A626226D4419FE97" modified="2015-03-04" version="1">MPPYKNSWATNAWNFWRRQWCRYPAHDELFQIFHQRCSGLAKCQDNNQNGLWRIIRSRSDFNSTSSEPTTFISKIVSSNDSQTIHETVRSTQEEISLTTPFIILVVLFIFISLLSLLFLFWRRKKAKNFETSLVKKEEIIEDRSLSLESTLLSHNRISEESNESSARPKLSPVTHKDTLILDIEKELIVEPPLDRHPALKFIDVNNPFPPHPGTRVMMPEILSPLPSPVRQERNSKHMSYSPATKAEPSIAISQETILKYSSDDADLSLLSKETSDKDFYSDKPRSEVEKFKSSSILEKGYQSKCEIIKEEFENGSVQEDYIKLKSNSETEAHPWLQLFSKKNGPRSPVFTNMDTNQSVNVSSGEYHKKIAPIIQDKSDQIHLMSDRWSKSTLELTDSPTNVASDCYIPGSWINSTSLDDINIHNSDIKSYHSSDANQNFGPKKFISLDLGPEINSLYPSKVDYLRNNGSENTNNTDNNYDTDDENYNFGSKIDVPVIERSETKIWRRWLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P805</accession>
    <name>A0A0B1P805_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000907">
        <property type="protein sequence ID" value="KHJ34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P805"/>
    <dbReference type="STRING" id="52586.A0A0B1P805"/>
    <dbReference type="HOGENOM" id="CLU_017269_1_0_1"/>
    <dbReference type="OMA" id="SDSFYMA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="743" mass="83057" checksum="A45826264C23F51B" modified="2015-03-04" version="1">MISPLSTDNVMASKKNKSHPATCRKVTPAIPLSFLRIRQQIQAKRATILLEAKNAAQPSLQDIGKQEDPDEKKTLPQCSDISIKSNGIDNLMIDHEPNSLIISALAEKRVENTTELCSSKEPPDKLHNESKAANVEARVSKEETGHLTQKSNQTDNLSPNVVSGTLFKNDNLNFKAGEISNQQSTRVPIAHVNEKIMVCDNSESSKSSPAPPQSTAHPTPSFNYEQPLPGRHLTHRFHSGFPLNQSNIYSPLDQPPSCGYYVSMNGPGNPVPGDQFCRRQAFPVRSWQDISPAVNQIDACRLCDPTTPHSFQGSYSSAQERDFSKNFDIQASPAISNNRFSGNLDFIRNCPTNSLINANRDNYPPPLPILQNNIPQVDLFDGLIKYLSSQFANPTFADYNLELRYSDDRAAPVRIPGHSLIFARSIKLRHMILSARNETDGVSSKTLLIESDDRFLSTDGVYLAVHRLYGSPLLDLGAIIPIGPTGQYQLPSISISNERFDLALGYAAAGHLLKMEVVVDRGCEIASLALNWINLERALDFALDGGLEPQWKIHSWDPESPRATYGPSVNLIIVKAIGFICHNLPVHFQLDTSVSEARFALRLPKTLGQRQSCLSSHLSHIKFGDHTAENCSQLETQQIPTVVLSRILISLPWELLRYIFESPHLANTIESLNLRHQILMSVVQEREKRRLRVYNSPVPNLDRQKDLLKWKIVGWKEEVEALRGDEIHPKLIRSWADFRNPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P808</accession>
    <name>A0A0B1P808_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001398">
        <property type="protein sequence ID" value="KHJ33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P808"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="119" mass="13105" checksum="F3FAAD83F63C3168" modified="2015-03-04" version="1">MRQRRERAWHARLMICTTAISSIESSLANFKDEIEIEEVAAFQAYLQLAIANFAAVDTSPTPPKIPSHSRPSKGSRHGLGNDKIAANKVAIAIPRNIPSLESSLRKTQGTSSHQRSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P834</accession>
    <name>A0A0B1P834_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000662">
        <property type="protein sequence ID" value="KHJ34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P834"/>
    <dbReference type="STRING" id="52586.A0A0B1P834"/>
    <dbReference type="HOGENOM" id="CLU_1826730_0_0_1"/>
    <dbReference type="OMA" id="KYKFVTV"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="16244" checksum="3C69CAC7F0B6717F" modified="2015-03-04" version="1">MIKNEMALRNILGVIPTYMRPPYSSCSAESGCEDDMKDLGYHITYFDLDTQDYLNDSPDRIGKSKTIFKDALIGKPSTDSEFLAISHDIHEQTSEQLVDYMLQNIQARGFKAVTVGTCLNDPKQNWYRSDRATPRYQRMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P899</accession>
    <name>A0A0B1P899_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ubiquitin-60s ribosomal protein l40 fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P899"/>
    <dbReference type="STRING" id="52586.A0A0B1P899"/>
    <dbReference type="HOGENOM" id="CLU_010412_3_4_1"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="153" mass="17615" checksum="9AB81CFE308D9BB5" modified="2015-03-04" version="1">MFNARKQLHADVSKFLYEEFRELTKHISFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCDKMICRKCYARLPPRAVNCRKKKCGHTNQLRPKKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E6</accession>
    <name>A0A0B1P8E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8E6"/>
    <dbReference type="HOGENOM" id="CLU_1409767_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="193" mass="22464" checksum="73A80E171BC6E37E" modified="2015-03-04" version="1">MDCNFISKNLALQEKKSTQSSVYHELIKIYGLLTGRLDDSENFQDYISTAQNSSDSSTCPTSRVSQRTSGKFYFPNSHIEYSLNEGEENIRLPHVQRTSLDVEDGIRMETDIDEGYYEYQSGISEMDATQVQLEALTTDRELYMSQIENRLYGPEKIGKFFRWRRSTDFIYEGKPVVRNKIRMRKKIPPRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U4</accession>
    <name>A0A0B1P8U4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000516">
        <property type="protein sequence ID" value="KHJ35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8U4"/>
    <dbReference type="HOGENOM" id="CLU_177979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="104" mass="11752" checksum="F243E1CDBADD5385" modified="2015-03-04" version="1">MPNLTVNKNNSWASRASSGHISVANNFNWRPFTKLTPPQVQSHEDRRVMIRLECDHEARKTEPFFLHQKLQRVLPYPSLVADAIQVPSVIAILALNPAKAAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8V1</accession>
    <name>A0A0B1P8V1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative abc transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001621">
        <property type="protein sequence ID" value="KHJ33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8V1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8V1"/>
    <dbReference type="HOGENOM" id="CLU_000604_45_1_1"/>
    <dbReference type="OMA" id="VRYYMRL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="372"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="679" mass="77707" checksum="6AC916DCCFE53DEE" modified="2015-03-04" version="1">MRIIRTNFRLEWPSSRQFSALSQAPIVKIIDGTFYRRHPNSTNGHTQTNKPLFANLNFELKSFPDREEHWAIVGPSSSGKTTLLEVLNGEHICVPPTARSFPFLDGKTENLSRNSLFNPQTAIKLVKFDSDNGLDSQIIRGAYLSARYETRRENEDFCLRDYLEGNTELNPMPNTSETKSYPLGLRWLVGELGLIEFMDMPVLNLSNGQKRRARIAKALLKNPDILLLDEPFAGLDPITLLDLKSMLYTLVKAHNQRLLISLRPQDQLPQWITHAIYLSDGECHIKRMGPVKNIFYKQIKHRNQREDVKSTEIGVNEENSKNKVWNQKIGRTYTDHMMNRDHITTGSTNDVNGRHDDIVRGEPIIEMEGVKLEYPNMQFFGHWPQKNSDETSKIVSHNGLWWTVRRGERWGIFGPNGSGKTTLLSLITSDHPQTYALPIKLFGQSRLPEPGKLGISIFQLQAKIGHSSPELHAHMPRSFNLRQVLESAWSDTPQGSPNLNCEAQKRIDAFLRWFEYDLCPKSTVRAENFPCERATYWADKLLFGKIPSSSQKIAMFLRAIIKEPDIIILDEAFSCLDDVVRNRCKLFLEYGERRRLLSDATSMNTSSSTINLETDHLKNIEFGGLKNHQVLLCVSHDSEEVPNCIKKWIYLPSPKTKSSARFGHIKGSLKDNWNNIWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8W0</accession>
    <name>A0A0B1P8W0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001618">
        <property type="protein sequence ID" value="KHJ33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309093_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="954" mass="108298" checksum="D020A008BF895541" modified="2015-03-04" version="1">MSRKSMKLIKPRRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTEINEADQAKKIEEADHVTEIDEADQAKKIEEADHVTEIDEADQAKKIEEADHVTEIDEADQVTEIDEADHVKKIEEADHVKESEEADQVTEIDEADQAKKIEEADHVTEIDEAGQAKKIEEADQVTEIDEADQAKKIKEADQAKKIEEAGQVKESEEVSKNEEAKVVVEANNTKNAIEIKKLNDSKVSIICVGEEFNSCPTHDQSVASKFVMPPCQMRYKRNISRDIAALKYRNKDYDLQPKYLSNSQPSTTLGLYPESVSETNTKKFKEIPTEIYTDAPSKNSMSNLSTKEIKEMEKFNLTNKSEYYPALDQNHDCMPFNQIIKYQEDSCINQKNMSLNIEIGAKSNYISSKPNPCCESPSKISFTSKNHDWLSTSSFSLSESDSTQLENLSLESYVELENIPRVNENGNKSEEKIGEKENIMTQDSDYDEIPDQKYSNLSGETLGLDTDYSKDYALMKSQFTDTQIEKGIVNLDESTFSKNELQSLETKYIIMEEEFVSKKSNDTNNCKASILTREKISHSSIFDFKNYYERRLSYDSSMSREIPKVLVTALVTKDRQFITDQADKKHLLLSRSLSENDLSRIKKKYQDNIKINSLPVLPTKPNQIKESMYSSITPKSLSIFDESISSSTSEEYLSPREEISNTDSIILSSWQGSNGEVTEGGGLEIKTHTRIKDSEDEICNPHLFIDSSTSHNLQNPLVDQANTEYQHETSFKPSKESSQTSDNPALKNTTQSDQETSMSTVSFFQRARALFDNQQQTRGENYKREGKTVRPLSGFFNLRGGISGPKQRFDNQFLLISEDEESIHNSTDLPTENPVVTNQPFTPKLNSTTSMPINFNTKKQNKRTEQSRLFFYESLQRAVSTSPKHSPVFQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8X4</accession>
    <name>A0A0B1P8X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubx domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8X4"/>
    <dbReference type="HOGENOM" id="CLU_020031_2_0_1"/>
    <dbReference type="OMA" id="VYAFVEC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="3">
        <location>
            <begin position="175"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="57725" checksum="C7F63FF1A0EEC0C1" modified="2015-03-04" version="1">MAAPEPDSHNLSEQQKLALESYTAVTGQNIQEAIPLLRRSQWSVEIAISKFFDGEFPDPISEITTAQDFSLPRSTRQMNVQQGLLNGNKKSLSHEKQPDQAPRIVPQPETDMIRQPPYMLAILFTPFNLLCRLVSSSCNIFYYIFSFSNLRSQNFMSQRQSLGRRPLKPRDCAARLKREFEEEYGSNSLPFFEGGYAQALDLAKSHFKFLVILLISPEHDDTTNFVKETLLDPLVQEFLQKSENNIILWAGDVRDSEAYQVSSAVKCSKFPFTAVVAHTPNISSTSMSVILSISGTIDTAKYLSKLRVAIMKHEEQLSIARTNRSAQDLERNLRQQQDSAYERSLALDRERARLKKEADAAAAEAKRIEMNRQATAALYAEKKLQWRKWRSNSIKPEPGPDDKDIVKVALKMPENLGAGRVIRKFRANDGIEELYAYVECFELLQSDNHLTASKPMDYDHEYQFLLVQSLPRVVFHVNQGDTIGEKIGKNGNLIVELIVPEDQESKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P939</accession>
    <name>A0A0B1P939_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative choline oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000481">
        <property type="protein sequence ID" value="KHJ35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P939"/>
    <dbReference type="STRING" id="52586.A0A0B1P939"/>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="393"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="611" mass="67358" checksum="C5DF82D632219BEE" modified="2015-03-04" version="1">MTTCTLSSQALDYDYIIVGGGTAGCVIASRLSKYLPEKKILLIEGGPSDLDNEKVLNLREWLTLLGGDLDYDYGTTEQPNGNSHIRHSRAKVLGGCSSHNTLISFRPFEYDCQLWESLGCKGWDFKTMTRLIDNLRNQILPVHPKDRNQICKDWVESCSKAMNIRVIEDFNEEIKETGGIKEGVGFFSIAYNPENGHRSSASVAYIHPILRGEEKRSNLTILTNAWVSKVNLKNKTVQGVNLTLQNGNKLTVTAKCETILCAGAVDTCRLLLLSGIGPSKQLSELSIPIMHDLPGVGENLLDHPETMIMWELNTPVPQQTTMHSDAGIFLRYEVPDAAKSNNDPLLNPKSLADGEIADIMMHCYQIPFCLNTARLGYDIPLNAFCMTPNIPRPRSRGRIYLTSSDPSEKPALDFRYFTDPDGYDAATLVAGLKAARKIASEKPFSNWLLREVAPGPLVQTDEQLSEYGRKVAHTVYHPAGTTKMGDPLDKMVVVDPELNIIGLKKVRIADAGVFPVMTSINPMLTVLAIGERAAELVAAKAGWQYVRAKLQVQVRNLPVKTKSSPSRGAGVNAQYALHVWDSQEDSHNPSLQDSHSSPRVSIVFVSTSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P977</accession>
    <name>A0A0B1P977_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000462">
        <property type="protein sequence ID" value="KHJ35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P977"/>
    <dbReference type="STRING" id="52586.A0A0B1P977"/>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="221"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="34080" checksum="F58A126B5EAFCEF2" modified="2015-03-04" version="1">MGKDAEPVKQSVMGVPPFVIDFLMGGVSAAVSKTAAAPIERVKLLIQNQEEMLKSGRLDKKYDGILDCFKRVTANEGVASLWRGNTANVIRYFPTQALNFAFRDTYKSMFNFKKDRDGYAKWMAGNLASGGAAGATSLLFVYSLDYARTRLANDNKSAKSGGERQFNGLVDVYKKTLASDGIAGLYRGFMPSVLGIVVYRGLYFGMYDSIKPVVLVGPLEGNFLASFILGWSVTTGAGIASYPLDTIRRRMMMTSGEAVKYKSSFDAGRQIIAKEGVKSLFKGAGANILRGVAGAGVLSIYDQLQVLFFGKAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C1</accession>
    <name>A0A0B1P9C1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001133">
        <property type="protein sequence ID" value="KHJ33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9C1"/>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="728" mass="81315" checksum="DFA15B312932E92C" modified="2015-03-04" version="1">MTFESKFKSSFPAIPTSLNAGDLEMSGHDFFLNNPTLAQPHLGLRARLSQIFINRWTVLILLVLCRLLLAIRDINYNIEKAREESLEACTSVENVGSAMASMPHYLSKGINSLTAETITKTIDGLMDMMMDTLEIVSSIVLFVINMFTQTYACLITFAVTGSLTASIELIEKVGKFLNESIGPVTETLAGDTKKFQDGLNNFLKKIQLPAIFGKTIPVPTIDISGPIDSLRKIKIDPTVMNKELDKLNSSLPNFADVQKFTENVVKFPFNQLGKQINESKASYTFNHSIFPVAEKKRLTFCSDNQIINDFFNGIVTIISKARTLIIMVFTIVAVLLCVATAYKEIRTWNKLHDGSNSIFSHIESYQDLIYFFSRPHTSLLGVHMSIKLFSSKRRRNLLRWFVAYTTTAPALYVLSLGVAGLLSCLGQFILLKIVQKEVPVIADEVGKFTELVVKSLDDASKQWAIDANGVIYQTNMRINKDVFGWVQTGSEAINGTIDQFTNEMTKVLNVTFGGTILYKPILEVMNCLVGLKIASVQKGLTWVHDKAHVNIPEFKTDVFSLGAVASLATSNTSDTADSFLASTGDLTSDKITSAVTKVIAKLQDSILEEIMISSTLILIWVIYVLFGLSRVIFENLRRVKVHGEGGPPSYSEDKSEILKKNFYASSYSRYLPDFARSKVTSMNSRSRWSHDNENEKINEISDYPCVSKLKSLFTRSDRENDIFRGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D9</accession>
    <name>A0A0B1P9D9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D9"/>
    <dbReference type="HOGENOM" id="CLU_1797874_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="16196" checksum="6B36E3609D31E96E" modified="2015-03-04" version="1">MLANEIERVSSKRPAFVKLYGTLKPDALHRTWMAFFTDTPRVGFRVFDESRVTKVFKKKQPIEFCKRKADDREYQVTVRAIAVKAKAAIDKDSDRSIEILTNSQSSNTSATNNKTPNNTQSSNTSMADSNEALGETATSVEMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W5</accession>
    <name>A0A0B1P9W5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000377">
        <property type="protein sequence ID" value="KHJ35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W5"/>
    <dbReference type="HOGENOM" id="CLU_711694_0_0_1"/>
    <dbReference type="OMA" id="YATIELN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="42732" checksum="EEB72046D72295E0" modified="2015-03-04" version="1">MKLNPLLLPIIIIFNGTIALILSVIVVVGNAKSDTLQKYATIELNTSTIFQDIIKTTSSSSNSRRDLSDILPTPLPSQPRFDARGLIVARADDPLSRASSFFNSIRTSILPQPTGAIAGGFSSLANQALSQIAKIFGESINDALNSLISEIVDEVGIREWYGLYFGVLCSADYKPNFRDPDATLANISCSSLRGSVDDPEIPSTFQVGTTTLDVSVLDIPSKLTKVVGQLTTVLKILYILGIVGIILTGVLILVSPILFIAKFRRPIIHLGIGLIATLAAVLLLLTALLQSIIAILIGSIINQLASGFGISAKAGVPLLVIAWISVILVSIPATILLNLWFNGVYIRRAKVALEKKRIPVSRNSLPMSRNLLAMSVDNSNIAQAVERSRNTANIQKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Z3</accession>
    <name>A0A0B1P9Z3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gpi anchored serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001411">
        <property type="protein sequence ID" value="KHJ33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Z3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Z3"/>
    <dbReference type="HOGENOM" id="CLU_104756_0_0_1"/>
    <dbReference type="OMA" id="NTDILTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061997" evidence="2">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="19034" checksum="EC9BDFAAAC3E6DC4" modified="2015-03-04" version="1">MLSSIFLSIPLLSLAASAVDLNSIPLPGVNHLDTGCAAQAVLDTCISSTTAIATACALTDYACLCQKNTDILTCFNNCPNDPRLSAVRSTQASYCANASAYPSSSSTVLPPNSMSSMTMSTQSSVNPTSSMTMSHPSTTTTPSTSLQSSTGTSTSSSPTASATSGSSSVFINQFVMLFPVLAILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA29</accession>
    <name>A0A0B1PA29_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquinone menaquinone biosynthesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000352">
        <property type="protein sequence ID" value="KHJ35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA29"/>
    <dbReference type="STRING" id="52586.A0A0B1PA29"/>
    <dbReference type="HOGENOM" id="CLU_037990_3_2_1"/>
    <dbReference type="OMA" id="EKLMRMG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="36402" checksum="A8D0315A3382735B" modified="2015-03-04" version="1">MGGILSTSKKSAFGINSQGNSTTSRPTLNNRIRYHPIPLLISGLALAYCAGYITFIVTKIYRADPSNIIINPLVQADVSFRYNSIARTFDNTVDSNEYWLGITSLRKMLVKKAQGHVLEVSVGTGRNLTFYDWNFQGFNKLGRPNASDNIKKGKVKSFTAIDISPEMLKIACKKLEAFIPDIIGVRWIQGDAAAPDTIPAPPKSMSGNGLDGSAKYDTIVQTMGLCSVKDPVRLLKNLGEHVMEEDGRILLLEHGRGRWKWLNFMLDISANDHAQAFGCWWNRDIQSLVKESGLEIVQIMTPKWWHGGTTWWIELKKPSSKPTGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAP9</accession>
    <name>A0A0B1PAP9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000444">
        <property type="protein sequence ID" value="KHJ35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAP9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAP9"/>
    <dbReference type="HOGENOM" id="CLU_726027_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080578" evidence="2">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="41500" checksum="C8BF821749E36C4D" modified="2015-03-04" version="1">MISKTNKILIASALFCFSNAIPLQEREVPQEHSHEFLLDSVRNSLKLDNPSNFKDPVFPLLGDKAAAQGAGNVTNLKCLQRKVADQAFTNEKKAGNTEGMGNALIYAALERNTGAVGKASEACDEPAVNPEINALRQHQDPASPGAKEANKELVLTLAKQLSSIGVDPQRAAMSATFAPGQIGDPTAKGNSCDDQDDKMGCIFTKKLIQVEATPEEIDAAVKSSTSSSSSKISSESSDDSKSDTTSSNIKTKNAAKRDLKKRDQFLKNNKFTNILQKRNGKSNLVPRHDTSPTNILKRDLQTSKSSLNNLRNEKRSIDNSLEKRRVVMTPDIQKQVHSVKSTFSSDFEVGHLNKGEIDINNKINKVKRDDDDNGQGRGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBA3</accession>
    <name>A0A0B1PBA3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ph domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000785">
        <property type="protein sequence ID" value="KHJ34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBA3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBA3"/>
    <dbReference type="HOGENOM" id="CLU_038067_0_0_1"/>
    <dbReference type="OMA" id="KVGNAFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="303"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="503" mass="56609" checksum="4F035B4956721338" modified="2015-03-04" version="1">MISPGAHSNNLVSRQLSMRSAMSEDAIPTEDPKNTVDLLFERFIAWKYVVDTFEDYIKTTEKVQRSQAKEYQRVLKTLQGPLRAGHHFDQKVGGIASLFENMRQNIHELVNSYLETEKNIKESTIPIIEQLRKEIKNQSKEFSSVAVKGAKDVEKARNLTQKYIELLGQNVAGFESSGSRLHSTEDPYVLHRGVLHHLHKQIIEENSQRQVLVTLQNNFHQFEQHVIEVIQTSLSSLTNFLNTQAQSQQEYYSDVMRTAQAIPLDFEWNGFLTRSSDILVDPSTSDRSIDTTTFPNQDHKSTCPIIAGTLERKSRNKLSFAGFTTGYYVVTMSKFLHEFKDEDFAQREPDPELSIYLPEATIGVTSGEKFSVKGKDVSKGLSSKLSGNSDLHFKAASPEEAQRWVQALQGVIGQTHMAINNPIDPNVEEETKTTSSPPIYSEENTVVITEKKILSSAQSQTIHDEIQSDTAIDTPGPLSSNLVETKVSKPEESQVEQTSEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBA6</accession>
    <name>A0A0B1PBA6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000365">
        <property type="protein sequence ID" value="KHJ35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBA6"/>
    <dbReference type="HOGENOM" id="CLU_611389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="448" mass="51977" checksum="B352388F73B11265" modified="2015-03-04" version="1">MDSLLVLETFKSSACNKVSATYYSWNNRVNKENHFQPKSSARSVSQAGNMNISPFQQKRSSAMPTQTFCHYTNMSEVQLVDTQYAIKSNYPKAFLSRCLVASNNAKNHEMEKLRMKMLCRNPVIQTKSNIDVKGLIVGQMLWGDYSFLQTDSVDTKNESYNPAISKDSKIMMKKYLKMMIREFGHGVKSTLNNKSDSNKKPMASATFRHNRTSQNMKIVHNHETSFDVINQTKKNETMDQYYVIEKSISLSRLNLYLELIYPEESQQFDQLIPFPIATKNRRLETKTIETHFKFKRGAYTRFKKLTEDLKELKLLLTMSKSEEYSKKPNLTIKNALENINMILAERNLAVQKLATELHQSLQVIIMERDSEILINLPIRTKKILSIYFNRNDYVSKIFNEINKLENSTITQIFKINIKQPECIKAASHNALILQATIYQLHQQKVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB9</accession>
    <name>A0A0B1PBB9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000983">
        <property type="protein sequence ID" value="KHJ34231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB9"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB9"/>
    <dbReference type="HOGENOM" id="CLU_507342_0_0_1"/>
    <dbReference type="OMA" id="QDIACET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="537" mass="61299" checksum="660867BB95CD440A" modified="2015-03-04" version="1">MEVVICYCLKCKSEIGRFRNAWNGIGNTYFSPIYNLVSGAGLETTGDIYEAANGSSIQNSLLRDVVCAKCRVVLGLRCDSAPDNHILKQNQLILRLKETTIISEGSGKVADLSVLKVIPLKDDKNTNSSTFPQTPSTIPSIRPSVSHSSFRNHKFSGVYGDFSEQHNSKRLQEIAQPKQHDFETEINSLTIGVEKFRGWAEETILSQQKDIDRLSGTMLRIERDMQTLKSYMQELNNKFASDYHSKNQCKEVAEVRNEIKRVNVRLDQKEEVPEWNKAASLLARNMKTIAGDVKKLSSQAEKISGFKKTLEDLASRLEYLEIQDQSIDYEKIPSLNRDISSETLSLKRNHDLVERNAWDRRKTDDQARMKFKKQRSDEIRQKEDLKSNSQKQNLDIVDLVSPEPDLLNVDKKDKINLEQDNLPAFKRGISHQTPQVLIRASNNAVNLLLQESKKSPEFPPRAGSITDPKSHLLLKNDVIEEDKKRRKSNSIIQDSSKRLYPILSDNIERKTDNLELNHYAKLVGRHLRARKSKALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBC0</accession>
    <name>A0A0B1PBC0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001134">
        <property type="protein sequence ID" value="KHJ33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBC0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBC0"/>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="OMA" id="IYCCTPS"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="55476" checksum="3C0EA785D1D65582" modified="2015-03-04" version="1">MPITVLTDRQVKFLLNNLTTDEVLNLQNSMRCALYDYATGASSSQVSTDDQPHKTKVSARNGTTTLFMPSVISGSMAVKVATFTTPSAYTGSSAINKSNSKHEVSPQGALTLMTAEGIPFAFINSREIIAFRTALTSSLLISRRSKVKVLTCFGCGRQAYWHVRLTLLLRGSSIKKVNFINRTLSDRAAALLKEFIGFDPEIKKAEGWSDTSFNLTSLNLGDVERALKTQVRSADVIFCTTPSTVPLFDPTILTSNEGRKRARLIVAVGSYSSDMIELPPEIIDQAIRPQTTNHFFQRRAEEGGAIVVDSLTCLRDAGELVEANVRADRTVELGELVMLEYIENEQAMVDDYDDGAPQSQISQDNLLVNNSNFNRGVFRSDSIDSCSSGTPLSKITSRKSSTNLSKPPSSKRSGNRSRRSSDSSNAWKRRSSVTESINVRLRKPSLLSLRSRKTQTELENKLSRWLSIGNVIYKSVGIGLMDLVSGIDIVKLAKEKGIGTTISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG2</accession>
    <name>A0A0B1PBG2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative snare docking complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000339">
        <property type="protein sequence ID" value="KHJ35593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBG2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBG2"/>
    <dbReference type="HOGENOM" id="CLU_016216_2_0_1"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="712" mass="78954" checksum="17DF93070978A423" modified="2015-03-04" version="1">MDSKQISLRARQIKSIIRMLNLNQDSDDDAIELDQSTSSSLGVPSTPLLNSNGDPIWKILVFDDLGRDVISCVLRVSDLRAWGVTMHMNIASNRYPIPDVPVLYFLEPSPRNLQLITSDLSRGLYSPAYINFLSSIPRPLLEDFAKQTAEAGTSENIAQFYDQYLNFIVSEPDLFSLGMRKQNAYWALNSALTSDDALEQIINNTVSGLFSVMVTMGVMPIIRCPKGEAAEQIAMRLDRKLRDHLLNSKENLFSTSAYKSSTPGIPSSRPVLIILDRNVDLIPMLSHSWTYQSLVHDILEMRLNRITVEIPIDENNPGKGVTKKVYDVSSNDFFWTKNAAMPFPHVAEAIDSELTKYKEEANEITRRTGASSIEDLQNDTSASAQHLKTAITLLPELRERKTILDGHMNILAGLLNGIKDRQLDNFFQLEENIVKQSKSQILEVINDKNRGTDPYDKLRLFIIWFLSTAENITRQDMENFEENLKLAGATTSSIAYVKQVRNTTRMTMMTSAPAQAKLNNTSTTPDLFRGLTSISSRLTSTLKESGVSANFENLISGVKNFLPVNRDLTVTKITESIMDPSGASSSAIAKTENYLYFDPRSATARGTMPPVSFSRKGDQMPGGLGRGEGASFGQRRQGFSDAIVFVVGGGSMDEYGNLQEWAKRTGVGVGGAGSEKGATRRRVVYGSTELINARDFLQTEMEKLGTELIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN0</accession>
    <name>A0A0B1PBN0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000310">
        <property type="protein sequence ID" value="KHJ35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN0"/>
    <dbReference type="HOGENOM" id="CLU_1876977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="136" mass="15101" checksum="9F54FF6C26F6AAF9" modified="2015-03-04" version="1">MVTDLQAQLITAFQQSWQNLASAIRGHQFPDDLNPEPLQSSIASTTDTPEKKMVCSLLICYDVKFGEMKAQLESSNNKNSKSASELVHAQGQVIELNKAISLAQQEILHLSQSSSLKNQQLEARLLDISNLKYKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBZ4</accession>
    <name>A0A0B1PBZ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative yip1 domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBZ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBZ4"/>
    <dbReference type="HOGENOM" id="CLU_108131_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="153" mass="16933" checksum="6895E1D967F53158" modified="2015-03-04" version="1">MSGAATETGYDVVVDVDEDGDLGHTDLQEDLEFHSSNFNNFTSTTNTRKQPGAGLPPPATADTTSKKYMIWSLPFYAQFFDVDTAAVLSRCWATIYPRANFTEVMEGNPDLYGPLWIATTVVFILFLGGTINRYLSETNGTQFVYDFTLLSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC18</accession>
    <name>A0A0B1PC18_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000104">
        <property type="protein sequence ID" value="KHJ36232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC18"/>
    <dbReference type="STRING" id="52586.A0A0B1PC18"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="28552" checksum="0D6635EECDEF756B" modified="2015-03-04" version="1">MGRQSHRIREVIVKKLHISPSLIGRKKPIQSDFTLSPCSPEAHEEIIKAGNGLFLSGAKLETATNWVSVLGPTVPASVQMEQGLVEVSKVILADEIERVCSVRPARLKMYGGNRSFSPNLVGLFTKAPHGGFRVFDEPGIARPYKKAPSCANYGSTNHVADSCMAATECKNCGGPHRADSRRCLARPTRSGAPSKEQMKTYRQMGEREYQAVQRARIAEEKAAVVDRIETDSLSSLASEESLICKNFPATPVKESTAVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC68</accession>
    <name>A0A0B1PC68_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC68"/>
    <dbReference type="HOGENOM" id="CLU_792724_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="350" mass="38624" checksum="6714EBEB2DC6ACEE" modified="2015-03-04" version="1">MSPLTTPTRAQSILSPLSPTPTNRSRTIRFTNVDLDQPVRYSSEALYNPQDPFISPDIIPSNKSKGNISKFTEDVFDEIRDVMIGREQMSEEFSKAIDEATSSVQKLGLEHALGHLERGQASSSKPTYAEAIKTYPPNTHKPNLPPKPSKPLPNHTARTRKRDNRIFVRLPENHPSRAHHVHAVKSALVNKLGPEGAIVKTIQKVKLGLAIVPAYGKQAEQILKNSQVFTSVLGGAEKAEKWLTYVIDHVPRKPIPLDDESWDVTEDDALAEVQSITSLLPTKVVWSKKTLENPLPLGAIVSHFKQATNPFRLFGTSSMARLIIKSPTPIQGVSGAELLNTPIAKQLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ6</accession>
    <name>A0A0B1PCJ6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g1841</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ6"/>
    <dbReference type="HOGENOM" id="CLU_008092_0_0_1"/>
    <dbReference type="OMA" id="MYQNQFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="115"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="582"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="754"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="617"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="816"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ36402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="926" mass="98987" checksum="AF2D312CC1ED1ACD" modified="2015-03-04" version="1">MSEVQTRPLAPRGRGSGRGGRGGSSGGRSSRANGINGKKPEKILAKTEEEGEVGQLKKLYSSQVTIIKEMFPDWTDEDIVFALRETDGNLELTVERITDGTISQWGEVSKAKKDRLRTKVKDSPLSTSTETISQTRSLRGGRAGFDSSRGGRGRGTDRGRGGKSRGASISNSASTRWTNPSMSTPSDDWKKPADETSSISNPVDDWDTSGVKDTSVSVKVPATIVADGVQKSWATLFATTPAPKKPTTSQLERPVEMTKVDEVDKTPPIESSEIYSQPIHEEPTVVMPLETTSVELAEADDLPPSNTLTEENVGHLPDTSAPLQTATVASTVASSWDHRGGAESSTPYNTMQQNEQQEVRTSMGFQNSTIKGNTPGRTLNYQRRVFDQEEAVRMPGNREVDRTAVQFGAFNLKDNCEEDVDGGREEAETRAQPPQHSPVAPRASLPPVHQQPINVSDSSPVPMPSVGLPAASLPTPVTGLTSPAPLSSSSVSVQQTPQVNGQFSHYSKFAQGGVPEKSYDTFNQQTQPAAQSSFDGYPEQQTQTQQHAAHSATFSSAPNDYSSYYAADPQQRNIYNSYYQQQFGSQHQSSQATQIQDVPASHHRSYNGYSGPPGESPQFQHSASHQPQSRYVTASEGHNSGHTTPNPISQAPQPGASNQASQPQAGHQPQVPGTFQYGHPYYSSPYYSAYMNQYPGYGTGNYPAGPYAAKAGIHQHYQGYNISPGPPYEQSVSPGSAAFGVSSIHTRDSAVGFLSESRTGSAQSAQTPQTIGGSAAFSTGHDGFSRGYSYQSQGQPHYGGQQTVQQNGDDVKPFNDSKTASGPNPSIQSVRPGSATNATPGNSAIPPQSQQASYSGYPAHLQQPAHNIHGSHSASQYGALGSTGLQHQASGQGHQGTQYGAYQGFGGGNYYSNSQQRGGWGGNYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP2</accession>
    <name>A0A0B1PCP2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cd209 antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP2"/>
    <dbReference type="HOGENOM" id="CLU_491073_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="60697" checksum="6364048AA34194B9" modified="2015-03-04" version="1">MSVFKFFYNIQTSIIGAMSTTGILNRLKAKLTSQQISTKEITSLADRENEIKQKAVNQSICDAVSAAVNSEEFTKAVAEHLASELKPSLKNLDPTSYYDNLKLSNDKISEQFEDQNTKLTHLSTILETNNASTAKKISNIEESINNITKIQGDIEEKFKSLEEQQKSQLDHVAAEIVIIQEKFSTISSSLSAQIESARKVIEAAATTPSPELTKSLDTILKTLDQNSLKLDEVKTNDLSSDIMTSIQNLNNLQTTHTADLESLKQSNEKSLINTVELKSETEKISSSLITTIDQIDNIKTLLSDSKTSNSLAEILAEAKTSNESYTRCIGLLEEIKSKQTEILPIVSDSKLSLDSHTTALSEVKQTESEILDSLKSVNTTLSDQGQILIYTKNSITNDIATAAELTNASNSIEKLTKGSETLNDSLSDIKNIVTNIKPVTQNVDLSVLESSIQSVVTSIGQIETVNGSLLEKFDLTSIISNLETQSKQISDVKSSMEALASIDKKVDLTPINELINDLSSKFESQLATLNDLKTAIKSKENSHPSDSSTQDTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP7</accession>
    <name>A0A0B1PCP7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator of chromosome condensation-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000011">
        <property type="protein sequence ID" value="KHJ36462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP7"/>
    <dbReference type="HOGENOM" id="CLU_019419_2_0_1"/>
    <dbReference type="OMA" id="WPENILR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="552" mass="62222" checksum="88D16783A08DC2C8" modified="2015-03-04" version="1">MSINTNDNPSGSESDQETASRIVGAILDGIQPAHEISPSGELYRVIGRHHRIPRTALYNPNVLSHSSGGNLASDQDLSERRTRENENELSPLFILPLTDESADLPTSSRSGSGSSIRGQPRFGRPFLNRLFHRNRSALRENVHDSYSELQRASHQLDEASSNLRALIDNPISNISPSGTETQHADSDFRRIKRRKFNSENLDTLFTGFSYGKYGQVEPGKLKMEIVSCDGGIFEGTDMQHPAENILENDNTVYCTKSNRCNLILRHQGATVFCLKELCIKAPHSGYTAPVQEGMVFISMISDDLLARTAQYQIQYSPFRSEKRFRSLEEFRNYELQQFMSIRLGEDIPFTTLRNRVRRIYDTGRQDEECDHRTAQIPQDFTPENAPPFSVTTECSESDGEDSSARSTSQRYARLGIHFASSDDSDSFEEDGTSHPWRENSMLQVNRNNRRRRSRQSEAPRNIILPSTTNSPFTPSQGLGKNVEGGLMAPHARFFIERDKSKCTVKFDPPVSGRFILLKMWSPHHDVTGNIDIQSVVAIGFAGPRFFPAIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD71</accession>
    <name>A0A0B1PD71_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative atp synthase h mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD71"/>
    <dbReference type="STRING" id="52586.A0A0B1PD71"/>
    <dbReference type="HOGENOM" id="CLU_122989_0_1_1"/>
    <dbReference type="OMA" id="DDENTKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="126" mass="14090" checksum="76D4EEED483892B0" modified="2015-03-04" version="1">MFCHTLQNSLSLASRAITLRSTGMIMKRFLAIPTAVRKADLVQDMYIRELRAYKVPSVKPSDSEGQVQKFSPPLPAISPEEANLMNELKAYEASSVEIEGQVEAGSSRGEDDWFESEPEDDENTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDB7</accession>
    <name>A0A0B1PDB7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000101">
        <property type="protein sequence ID" value="KHJ36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDB7"/>
    <dbReference type="HOGENOM" id="CLU_1062437_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="28914" checksum="388052C3D483CEF5" modified="2015-03-04" version="1">MNFQGFAEKFAGGIEENSHNDIEMEASAAVFQTSGFGSHNSSQQHNVVNTTQQNQITHQLLFRELAGMYEDLVQKIVMENRALMDVLRAENRNIKHEVETLHIEVRSTYLAQRIPEKIPNCGPSQTTEMKIGKELSTLKPNPPAPKRAELPARPIFKETPQIISMAKLAAINAPPAGNPANWSIVQNGKGSKKKKAPKNEFPAPMKSVDAAKRRVIFLRSPEAPRATGTEAQDILYALNMHLLSLKDTSTSSVDKDAPPHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDL1</accession>
    <name>A0A0B1PDL1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000556">
        <property type="protein sequence ID" value="KHJ35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDL1"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="OMA" id="GFDHAIT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="172" mass="19318" checksum="6EF1363309D783C8" modified="2015-03-04" version="1">MSSQIGYIIMLVNENVRRDSFEIKGSILHYSSTKCKRVTRSILASEIYGMVSGFDLGLALITTLNSVTKSLRLKPIPLVICTDSFSLYQCLTKLGTLNEKRIMIDVMALRQSYERREIEEIRWIDGADNPADAMTKSSPNQALTKFIDSNTLSIRIDGSVDRPSPSDRSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDM3</accession>
    <name>A0A0B1PDM3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2714</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01000717">
        <property type="protein sequence ID" value="KHJ34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDM3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDM3"/>
    <dbReference type="HOGENOM" id="CLU_002513_0_1_1"/>
    <dbReference type="OMA" id="KACFEIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="237"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="594"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="774"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="950" mass="106967" checksum="31252A515F10C9AF" modified="2015-03-04" version="1">MDEEVFEELSDEDLIKALNQPTSALPTLVGSARKKRRMNSGSSQGQLTTYGEHDGLHDSHLLPGPDKFSQESESDSFLGDAKEKNELSSAEPWKSQGPNYESMGLESPSVKISNIIERQMLSIDTELEGLPSDAFSSPEPRNVENQYIGTGSSPLLPSPTISRQRLVAAHRGLRQTTLYGGHATQDETDLPQARKVHNYIVDLPPEPPTHHILDPENLKTWVYPMNLGAIRDYQYSIVKNGLFHNLLVALPTGLGKTFIAATIMLNYFRWTKTSQIVFVAPTKPLVAQQVEACFNVVGIPKSQTTMLTGGQIPALRAEEWSAKRVFFMTPQTLENDLVSGIADPKKIVLLVVDEAHRATGNYAYVRVVTFLRRFNKSFRVLALTATPGSSVEAVQEIIDNLEISKVEIRTEESMDIQQFVHRRDVDQILLDPSDEMTQIKDHLAKALQPLVNTLCAANAYWNRDPMALTTFGMVKARVAWMQSDAGRRANPGLKWTMNTLFAILASVAHGIKLLNFHGIYPFYSAIKDFRDSEEDSKKNPGKYRSQIINSPDFKKMMLLIESWLKKNDFIGHPKMASLCDTILNHFLDANEGRQGEDVPASTTRVIVFAEYRDSAEDIVRVLNRHGPLIRASVFVGQADSKRSDGMNQKQQLKAIQDFTSGTYNVIVATSIGEEGLDIGQVDLIVCYDSSASPIRMLQRMGRTGRKRAGRIVLLLMRGKEEESFTKAKNNYEQMQKLITSGKRFSFRHDLSVRILPRNVVPVVEKRVIELPLENTQNPGLPEPQRRPRVKKRPTKKFHMPDGVQTNFIKASNLDKGETSSTSNLRLNVTPRGSNKSQLVKIPTAKSVFLGPEEEEELQQKYQYIDGDDIQEVSMPGMTAQTVAQRSLRPICKISHGKFTERCVRLFKNLASFQNSEIYEHYQNPEREISLKGIDLPTLIDETKLRRKRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDP5</accession>
    <name>A0A0B1PDP5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleolar complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000056">
        <property type="protein sequence ID" value="KHJ36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDP5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDP5"/>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OMA" id="YYNNIVT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="337"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="564" mass="65097" checksum="6C23F26BF768C348" modified="2015-03-04" version="1">MSTNTPKAQKVMKRRRSSPCENFSSKKNFGDIDCVDGNDGINDRDNNGSTEGDDDAQAQILLLENAIFESKKNYNNIAILIKALDSDDKVNKNLSVVIISLCRIFSKLMISGNLTKRHASSEKEAVVNKWLKEQYSKYKKKLIFFLGKGYSRTTILALCMQLLRIEGQYLRVGEKYTFPTAFLMLILQTILSNQCDKIIRDQFCQEFIQKYTDIRYYTLEAIAKLVCTEMKYEYKAQNFDNYLQLLASIESPPKSTEELEKFYLPKPNTSIHTLYSVSQHKKRAQSAWLSLMQLEMSKKQRKSILKLMSTSIAPWFTKPELLMDFLIDSYDTGGSISLLALSGVFYLIQERNLDYPQFYNKLYSLLDAGILHSKHRSKFFRLLNIFLGSTHLPVVLVASFIKKLSRLTLNSPPSGIVAVIPWIYNLLKKHPQCTFMIHREIRDPHMKEMVEKEGMNDPFLSSEQDPMKTNAIDSCLWEIVMLQSHYHPNVATLAKIISEQFTKQSYNIEDFLDHSYNSMFEAEICKEVKKAPVVEYEIPTNIFTGSVIEYDSKSNLLKELWNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDT2</accession>
    <name>A0A0B1PDT2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDT2"/>
    <dbReference type="HOGENOM" id="CLU_030818_1_0_1"/>
    <dbReference type="OMA" id="WAYVHLI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="609" mass="68034" checksum="35D73ADF2733D8E0" modified="2015-03-04" version="1">MSNQNKHSQIGDKSYNIQPPEYSNIKLDSFPKGSQYEKELEASGSPKLRVDEESKPTTPLLLDTPDYEKSSSGFSNSTEYHLNSPQFDQERRDENKDIDRNVYLNCLGRYLITLFFCIGYVVIIMIWENNAATSAFGKRVFKSIITGISIGLSLNISGSFKEIALTMRWSLIALKKFNLDEIDLLLQSYNLITFYKLARVSRRPLIKICCIFWILVNILTQFGLASLSLTHNFDGDTMAVHLKAGRASIAKMSHFFPRSNHVGSNLALQDEQYTAHTYGGFALTFGIGLVSTQPTPGQRYQTTQPLLWLDKRNNLINFVFLDSPKGSREISPYSAYTDRKISVTYKCDSYSVLAGGDGTKSQIEVESVGTVILSKAVPESTTYLTRSNLTCEGDNRCSVVEVFESSDTDPWYYICKVSLGQTQNDPLAVSKISDKMAQVATASIAQIGYTDSQGFASQVYPRQSLWGQALKGDSQSMGMMIGIHALASIAGAAQFNPFKSYTTPHAPAPGFRLKLKHKGTFISILTLINLIQLGFVIIAIVLSKKGKANAWGYIDIIMLFKPITDTLPEICLNEDSKESRKLKSQLYARYEKSAVTNNDWNLKMYSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDV0</accession>
    <name>A0A0B1PDV0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative tetraspanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000359">
        <property type="protein sequence ID" value="KHJ35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDV0"/>
    <dbReference type="STRING" id="52586.A0A0B1PDV0"/>
    <dbReference type="HOGENOM" id="CLU_066479_0_0_1"/>
    <dbReference type="OMA" id="LGQCPLT"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="24691" checksum="5833E8F649151BE2" modified="2015-03-04" version="1">MKDSVLLAYVVFDLLFAITGIILLITALSMQSQLSQTPNLENVAKNLILDSCPLKAAIANGILVLAIFVMSIPSIAMPRARGLLKLTGYFVFVSAVFTMVLGLTIWFETLKTRKNLLAIWKMQDVSVQSLLQTKYQCCGYTNSTSPPFVVDNTCPNPTIAAARLGCVFPFSAFANNFLDVIFTAIFGMVGVDALFILATAILLKDRKEQARYRQIFEKNGGRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE08</accession>
    <name>A0A0B1PE08_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000342">
        <property type="protein sequence ID" value="KHJ35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE08"/>
    <dbReference type="STRING" id="52586.A0A0B1PE08"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26806" checksum="18624E7C26C0D15F" modified="2015-03-04" version="1">MSSNKIEFIDNKSDIKPQYISQRALGAYIATVCQPEASFDLSRAAQTVSPGINEAALLNKRLKWQKINSRRGLKFIKLDNKSLKIIVFTDGSFANNKEDMTSQIGYVICLADDKNRANIVHWSSTKCKRITRSVLASELYAMVVGFDMATVIKSTLEKVINSLSISKSSSSIPLILCTDSRFLYECLSKLGTTTEKRLMIDIMALRQSYDYNEVAETRWIEGSKNPADAMTKHNPGRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE09</accession>
    <name>A0A0B1PE09_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000643">
        <property type="protein sequence ID" value="KHJ34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE09"/>
    <dbReference type="HOGENOM" id="CLU_960410_0_0_1"/>
    <dbReference type="OrthoDB" id="3596512at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="32925" checksum="72878B51897E3100" modified="2015-03-04" version="1">MMRLCQILPNSTLEACNQEEFCTNLIKPLQGQWYQEQNSLMCSYSDLEYHQIYDERYNARYPCQAGIISGRLACGSNSKDIQARNSYTKVKSMKNYDFNRNIGVQQPAMRQATTITLAVLTTATLSNLPTNPTTVAPTITAIATEADVTAIVKTAWTTSIFHSIMAILMAKASILSTARLLEPDLVLVIWMGLSLPFLGLVFVLLVILTWREWEIRKVEERVARDCAILGVMPLPQWRELVKTMSSADIEKKLAMDLRLQKELQKLRREHGNTHDQDWNQQFRSLAAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEG5</accession>
    <name>A0A0B1PEG5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000564">
        <property type="protein sequence ID" value="KHJ35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEG5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEG5"/>
    <dbReference type="HOGENOM" id="CLU_021805_1_0_1"/>
    <dbReference type="OMA" id="IGRQFPW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="122"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="482" mass="55335" checksum="DED7C83C5AB8BA25" modified="2015-03-04" version="1">MVCMNDPLIRAIPSAQLIGRSHFGGLLRRSKSSEKKSKKKLVAREFELEKERQNQLDIAVRENPPTIYQAHEILKSNQSSISNDSHNDVASLKFSPLSAEIANFQLPNFASAVRPDWSMMVIILITDILILGTKSCGKTSFLNFLKSSFAPPPTKKISHLTDLREDIFAPPYPRIGNFEKHYFETTIDSDRVNLTLWDSQGLEKETIDYQLQEILLFIESKFETTFREELKVNRAPFSSRDTHIHFVFFLLDPLHIDQNIATFNSATLNNSYLNGQSEYSALDITGRMEDDIEIKVIRALQGKAIVLPIIAKADIVTSTHMDFLKRKIREKLWKANLNPFDVLETEDDVNDSFQTSSKTDTRSHVIADGEIEDLAKHKSLKPNRNSITASIKSTENTSRLGNCLKKNSTFPFSTISPDLYDPQSAGRKFPWGLADPLNSEHCDFVYLKNMVFYEWRDDLQEVCRNILYERWRTNRFLRCVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEH5</accession>
    <name>A0A0B1PEH5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000292">
        <property type="protein sequence ID" value="KHJ35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEH5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEH5"/>
    <dbReference type="HOGENOM" id="CLU_002656_1_0_1"/>
    <dbReference type="OMA" id="EFAVMLC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="465"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117538" checksum="A69652A64D68A76C" modified="2015-03-04" version="1">MPPKKKANKKTEGKEKSIETIPDSEKPESKEAEVKDDSGDDLAPSGGLMAMMRKRQKQKKIKELDDDSALNEDILNKSEIDFSGKVPVEASLDDEFEQQETKTKAKPSQANTHIKDDSDGEVGKDGKLLTKAQKEKLKKEREKQRKKENAAKKKTKAIVPKIAEPIKAVTETVEAPTASKLTTSGKSKKVPAALAKIKAQQEALRLQDEQNARLIAEEKARIEEEERREKEEAKRREEAKILKKQREKEKIEQQKRDGTYLTRAQREEKIRNEMKLNQMIAAGVRIGSDNKGEKKKPTYERKKKNTRKNPEEAKLEEEKALAEAAERARLEAERNLAEATAKAKQETDVATLTKSNELSDLDDWELATSDSKDDVKESWDADSEKEEDLSKNNTSKLNGTKVSSQQPKKSSNTSNDFKDDTSGSSSDDDEANVAKAALVARKKEAADRREKAHQAALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVEAIKTKTAVVNKDNLFDFKVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEQQTLESMKLLRDKCTPFIVALNKIDRLYGWKKVDNNGFRESLSLQNKGVQNEFAKRLADTKVAFAEQGFNSELFYENKSMAKYVSLVPTSAHTGEGIPDMLKLIIQLTQERMVGSLMYLSEVQATVLEVKAIEGFGMTIDVILSNGILREGDKIVLCGVDGAITTNIRALLTPAPLKELRLKSAYVHNKEVKAALGVKISAPNLEGAIAGSRLMVVGPDDDESEIEEEVISDLGALFSRVEKSGRGVTVQASTLGSLEALLDFLKVSKIPVANVGIGPVFKRDVMNCGTMLEKNKEYAVMLCFDVKVDKEAQIYADEQGIKIFTADIIYHLFDAFTAHMNVIAEKKKEESKMDAVFPCILKTVAVFNKTGPIVVGVDVVEGNLKVHTPIAAVKTNASTGVKEIVQLGRVTGIERDHKPINICKKGQPSVAVKIEMGSHQPTYGRHLEEKDALYSLISRRSIDVLKDFYRSEVSNDEWMLIKKLKPLFDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEV1</accession>
    <name>A0A0B1PEV1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000383">
        <property type="protein sequence ID" value="KHJ35461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEV1"/>
    <dbReference type="HOGENOM" id="CLU_2322090_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11165" checksum="2617008A9C18575D" modified="2015-03-04" version="1">MQALRGTNKVTSLSQREARLNVIFADQKATAAILNLIKRTCIGKKVNEDDTQSRELSRRENIGIADLDDDWPREYRVKGSILSQRTSDESKLLAQMIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEV2</accession>
    <name>A0A0B1PEV2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000235">
        <property type="protein sequence ID" value="KHJ35835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEV2"/>
    <dbReference type="STRING" id="52586.A0A0B1PEV2"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="24196" checksum="FF8223AC2FF7427C" modified="2015-03-04" version="1">MMGALKYIEELQKKKQSDVLRFLLRVRCWELRQLNVIHRASRPSRLDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQRSLKSTAEERVGRRCSNLRVLNSYWINQDSTYKYYEVILVDPQHKAIRRDSRINWIVNPVHKHRECRGLTATGKRSRGLGKGHGYHKTSAGRRKTWKRHNTLNLQRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFG2</accession>
    <name>A0A0B1PFG2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000159">
        <property type="protein sequence ID" value="KHJ36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFG2"/>
    <dbReference type="HOGENOM" id="CLU_891965_0_0_1"/>
    <dbReference type="OMA" id="THRAIIW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="34976" checksum="F8D01406B401D6AA" modified="2015-03-04" version="1">MSSSVSYSSSLNKAAIGGIVCGVLAFFLILGLIIFVLLRQRKSKLMNKNQEKESAKIQDFEVNSKEREPDIQAPITQSQGTTEMNTQAIESRILESTQSLNNFDLNLFPGPPREYSIRQIPEEEVIPSEVSPALQTINEQSPNLTECYKLPVITFSDHAFPMPASLLSAQSTFDRTDMVHEGESQDQLTNLPIKNNIILARPTQSHSKKASRDVTREEKLEFFPQTFEPHATLHPGFYMKSQNVPIKEKDRESPTLGIRNPVKITADSSSTHRNSHGRYRSDSESSKNSLSSINRKIISDEELERLGIGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFM7</accession>
    <name>A0A0B1PFM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFM7"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="152" mass="16514" checksum="1808D9525D48C322" modified="2015-03-04" version="1">MSNTTIDGRQILKHVAPSKLPITERPTSIRRERAWHARLLICTTIISSIDSALANFQDEKEKEEVVAFKAYLRQKISSFAATDSSPSPPRIPVHTRPNKGGGNSNGKGKDIDKISTKKVAVATPKIILSQGSNLGSSKEVELPIIIPSSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGQ2</accession>
    <name>A0A0B1PGQ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative heme steroid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGQ2"/>
    <dbReference type="STRING" id="52586.A0A0B1PGQ2"/>
    <dbReference type="HOGENOM" id="CLU_046313_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005422625" evidence="6">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="322" mass="36188" checksum="F78E140463CC7EA4" modified="2015-03-04" version="1">MLLFGLSVFIASIWLLCLRQFPRTFNFLVWPRSNNVVTNTPCQNKNETKVSQPEKFETLEHEENTKMERKSDNNQKEFFRESNLEKEISDNNVMPPPPLPSKKNTSFSNSYASIKDSDDILDPNLKPHKSKNDREHQNQPKNTTTLSLPKANLSPKTNSNFFTKSPSISSLSPLPNRVPNGLATTAVKSSVTSKSIKKVMLKPGHSPLDWARLSASSVNLSGLPSGTPYLKVPPSLLKQYTGRKGKDAWTVLGNKVYNITPYLPFHPGGEPELLRSAGRDGTKLFTEVHPWVNWEGMLNSCFVGIAVEESELHVENRRDEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGW4</accession>
    <name>A0A0B1PGW4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative snf2 family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1137</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PGW4"/>
    <dbReference type="HOGENOM" id="CLU_000315_18_3_1"/>
    <dbReference type="OMA" id="AMEYELY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23614">
        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="403"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="795"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1102"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1393"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ36091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1644" mass="189475" checksum="31DA6D2974E08454" modified="2015-03-04" version="1">MTRRRSSNSRVSEVHTPISEKNRILHSNRRVPKISTTVSSRNDPLKSKSNIAVIVPLPVRKWEYIPIGTSTTVNAVLGKLHGRDSGNLYKIEYDDGIEEEVSLDKLLSLKNGQKKLIFYNSQKSLSKIGNQNKLSPKSTPIYSSRKRNLRCARQDGFLNSADIDIESEEESDGPTTAVTKKQNLQRNQYSSINHRNSITSRSGGKIYDFWSSVKRKYEKSDSDEYIQPRKRAKMIHDETDFRASSSNSFNKKLGNSVFPKKIPLSLKKSDSESDELARPFRENEYQDSFIKLRQKKRRRSFTKLDGQAGKNKRKEFESFKKSDAESSISCETYESNESSETSFSPRRPSRKSGRKRSHKNMKEYNEDEEIYAEDSSNSTRRVTNTKEIFIPISKQNLFRSFHNKFCDVCFGNERNSNKGPSQLIYCQGCSTSIHKNCLGPRSNRDHLVTKIGHENFVLQCRRCIGIAITKDKTAPRLDVCIVCRELGLSCWAFSTKMSARQEEKLRKQNEGIDPITEISSELINNEKNVLFRCTGCKRAFHFEHLPPLKNQIKTQDDIEILRRLRLDEYSIRWRCKDCQDAPAKVVSLVCWRPLYPDLYEDGMTSDELCEDEKEYLVKWSNKSYFDCTWMPGNWVWGVTVTAIRKAFLRKNEGINLLPKWSFEEAVPEDFLQIEIVFDVRYDRNFIPRSEKIDKAAANMITEVFVKFKGLAYDEAVWMEPPKIENIERYQSFITAYNEFIDGKYFRQSSTSAMDHRLQMFRKLNFSRRVEMKEQPLQLTGGKMMQYQMEGLNWLLYNFHQKKNVILADEMGLGKTIQIIAFIVAIVKNHSKCWPFLVVAPNSTCLNWRREIKKWAPKLRVVSYFGSKSAMDMAFNYEMFPNNCSDLRAHVVITSYEAPISDRCKSWFTRIKWVGLIVDEGQRLKNDQTLLHTTLKALRIPFQVLLTGTPLQNNKRELFNLLQFLDTSIDAAKLDEKYEELTNENLPQLHDLIRPFFLRRTKLQVLEFLPPVAQMIVPVTMSIVQKKLYKSILAKNPELIKSVFSQSVKTLRPSERGNLNNILMQLRKCLCHPFLYSSAIEDRSFGDQTLYRNLVDASSKFQLLEIMLPKLHKRGHRALIFSQFLHNLDLIEDFLTGLDLPFQRLDGSINSMEKQKRIDEFNAPNSPLFAFLLSTRAGGVGINLATADTVLIMPHQDIQALSRAHRIGQQKKMLFFQLMTKGSAEEKIVQLGRKKLALDKALIGRMDVRDDPDHDLESILRFGAEALFNDDDKDDIHYDSASVDKLLDRSLIEAEVKDPEKDLGTRFSFARIWANDKDSLIEYDHDTNSAEMASQFSAWDKILKQREADAAVEALKNCQVFGRGKRSRQIKNYGTTDLELELELDEDINLSLSKHKGSDKQNESANDLDFTDVEQHDEIESLDSYRSIEKDEAILVKSTSVQETDLTKETASKVNLSDGTACHGNIISENQSLQLQKEILINDKNPAYHISRSLFIPPPQQFNPMFYQSYFSHLPNLIPNTTICNYGSQLKGITQRDEITRTYSHQPSTIIYDNMPSSGQISVLPPSQNEIYCCHCGLAHLPIAKVCPCYASVIQIRLMLDKISKCKKSNHNQTIEITLRSKLFEKINERKNIKTTSSVICIYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGW7</accession>
    <name>A0A0B1PGW7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative constituent of 66s pre-ribosomal particles</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGW7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGW7"/>
    <dbReference type="HOGENOM" id="CLU_025741_3_0_1"/>
    <dbReference type="OMA" id="HFINWSE"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="187" mass="21800" checksum="C90BB1F92FB30AD5" modified="2015-03-04" version="1">MSPSSEIMPKKTSTTSKEKPSTEISEKPGVLYIGRIPHGFYEHEMKNYFTQFGKVLKLRLSRSKKTGLSKHHAWIQFESAAVAEIVAKSMDNYLMFGHLLKVKIVPEDQIPENLFKGANRRFKKVPWNKIEGRKLNKPLTREVWQRRIAKEEKRRLEKVAKMKDIGYEYEPAKLKVVDPKIKDKAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIF8</accession>
    <name>A0A0B1PIF8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine-protein kinase nek9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIF8"/>
    <dbReference type="STRING" id="52586.A0A0B1PIF8"/>
    <dbReference type="HOGENOM" id="CLU_046009_1_0_1"/>
    <dbReference type="OMA" id="TTDGCIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="32530" checksum="20D1BE9E64D51C99" modified="2015-03-04" version="1">MKLWVAGFNAWGQLQPSEEDETPICSFPDNIYTFKVCLQKADKIDILWSGVSSTLVDVFNKVSIIGSPDEVTEILSQHPNLSSCIALAGNDKVAVIEDQSLKLYNSFHDYKIKNGIDANICQNIIQVVANQTSFTALSSTGDVWTWGDPRYFACLGRDIQDESPASVPCLVGDLHHLPTGPIIKISSGGYVSAALTEGNDLYIWGGRMGHSGIFNDLKSNPTPVDIEGADIVDMAIGFDHILALTSEGKLYVVGYGDCGQLGNGLKLVNNWCEIILSPEQCQNIIKVYAGYKTSFVITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUT5</accession>
    <name>A0A0B1NUT5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytosolic fe-s cluster assembling factor cfd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005014">
        <property type="protein sequence ID" value="KHJ30137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUT5"/>
    <dbReference type="STRING" id="52586.A0A0B1NUT5"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OMA" id="WIPVFAD"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="301" mass="32458" checksum="BEF1128CAB402A52" modified="2015-03-04" version="1">MSLEKVKHIILVLSGKGGVGKSSITAQLAFSLSLAGNSVGVLDVDLTGPSIPRIFGIESAKVTQAPGGWLPVSIHSSNDAAGIGELKCMSLGFLLPKRGDAVVWRGPKKTAMVRQFLSDVLWGDIDYLLIDTPPGTSDEHISLAENLLQTMNANQMPKAVVVTTPQAVAIADVKKELNFCIKTGIQVIGIVENMSGFVCPQCSECTNIFSSGGGKKMAEEFHFQFLASVPIDPQLILLFETGKIPVYPNNKSLHDPNQDTDSKKINQSIENTQVPLVEKYMSCSLYPIFQRIAKDIADNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVJ8</accession>
    <name>A0A0B1NVJ8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005893">
        <property type="protein sequence ID" value="KHJ29993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVJ8"/>
    <dbReference type="STRING" id="52586.A0A0B1NVJ8"/>
    <dbReference type="HOGENOM" id="CLU_790355_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ29993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="37678" checksum="647981FA48F9C49E" modified="2015-03-04" version="1">MTTTVRDQEDVEVVKRDDDDNRQGPGGRRGGRPNFGGDNDNDNDKLKRDDDDNRQGPGGRRGGRPNFGGDNDNDNDKLKRDDDDNRQGPGGRRGGPPNFGGQPNFGGRPNFGGRPNNDNDNDNDNDKVKRDDDDNRQGRGGRRGGRPNNGGDNDNDKLKRDNNIQTFTGTLGGLPPAVIETKGITRPFAVNDDTFVGKKVALQRSCDIQLNACSSAANSGAGGNVADCNEQQKKCMEAASASAKRSVVRRSIPSYLAKRQSSDLGSCTNPTVEFKEGFDGRKEASFKAVNQKDFNHGSTVKPGITLDFICQRLESTCKASLDTVSKCKAAATAASSLSGQEAADTFNKAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVS9</accession>
    <name>A0A0B1NVS9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005277">
        <property type="protein sequence ID" value="KHJ30078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVS9"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22072" checksum="D89C2C2135F0A00E" modified="2015-03-04" version="1">MWSLYRRERACHARLIICTTIHSCIESNLSKFSNEIEKEEAAAAAFKDYTHTAIAKFAAVDSSPSPPQIPAYTRPTKGDGTVKDKSFAKKAVIALPQKPKGVVVDKGVEKETPSLLVNTWATVARAGQKKVRAMLSSKTQVNPTGGQALRMANKVKPNSSASQTMAISDKRLLVRLLQEHEWRKLSPPVTREVIVKKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW69</accession>
    <name>A0A0B1NW69_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003848">
        <property type="protein sequence ID" value="KHJ30632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW69"/>
    <dbReference type="HOGENOM" id="CLU_1455423_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20801" checksum="9CD6DD1CBD33F044" modified="2015-03-04" version="1">MALVSNHLIPDNDYNEWISIVGHIAQRHDTLGKFNNRQSNLGMENNRQNEDPFSNNEARGSNNYSPELVISGKERGIPGDLDSTGDTFMGGVFNVGRSRGSSGETYVSKWKSPEQIERLRREKRCYRCERQGCNTRICPLGPAKRPKATKGVSINVSDLSSIDPSVYYKNGKDMNVDSNNDRGSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW78</accession>
    <name>A0A0B1NW78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ammecr1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003823">
        <property type="protein sequence ID" value="KHJ30642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW78"/>
    <dbReference type="STRING" id="52586.A0A0B1NW78"/>
    <dbReference type="HOGENOM" id="CLU_052828_2_1_1"/>
    <dbReference type="OMA" id="MATVEHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="28353" checksum="A11F275855724636" modified="2015-03-04" version="1">MATPQHCVHCFETLAATFEKREPLSLQEIEESWIEYLHAPNTESSKSKFLSARAAIPSLQASVPNAPIFVTWDIISPLDSNKLSLRGCIGTFESSPLDESLSNYALTSALHDPRFPPIALHELPNLSVSVTLLHDFETCNDPMDWVLGRHGIRVHVRAKKKSWNSCYLPDVAVEQGWDQEQCVFNCMQKSGWDGTKLTWRTVDEIKVIRFQGSKMSMNFREWKDWRDWMDKQPTGKENSKRRKNSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWR2</accession>
    <name>A0A0B1NWR2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004316">
        <property type="protein sequence ID" value="KHJ30403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWR2"/>
    <dbReference type="STRING" id="52586.A0A0B1NWR2"/>
    <dbReference type="HOGENOM" id="CLU_021803_1_1_1"/>
    <dbReference type="OMA" id="DHSVMYI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="119"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="392"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="591" mass="66082" checksum="451ABD8425E78C86" modified="2015-03-04" version="1">MNGSPEGKDGANLLGYPRHAKHTGRLHRHRVKVKISTLPALLKPLKMNQIYIHSSKYTIFRSQILRKAPRLSLNLGASQISFPSLNIKPCSRFSTMTLLQSGAPAQLSQARHYDPEILDIAKYVHNTPIQSDLAFDTARYVLIDTIGCGLEGLKFDECRKLLGPIVPGTIVPNGTKVFGTTYQLDPVNGAFNIGAMIRWLDYNDCWLAAEWGHPSDNLGAILAVADWISRTNRAGGNLANGKIVKVRDVLEAIIKAHEIQGCLALLNSYNKVGLDHVVLVKVASAAVISNMLGLSEKQTADAISHAWVDGQSLRTYRHSPNTMSRKSWAAGDACQRAVNLVLKVLRGEPGVPTVLSAPVWGFYDVLFKGKKFEFQRTYGSYVMENILFKVSYPAEFHSQTAIEASKKIHMLLAEQGKSAADIQEIVCRTHEACVRIIDKQFKPMDNFADRDHCIQYMCAVMLVYGRLEANDYTDGGEAATSPLVESLRRKIKCVEDPQFTKDYHDEKLRTIPNALTVTLNDGSKLEEVVVHAPLGHKLRREEAKPEIIAKYKRHLASHYNEERVQELLSLANDKEKLHEMTIDEYIDLYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWZ0</accession>
    <name>A0A0B1NWZ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003499">
        <property type="protein sequence ID" value="KHJ30867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWZ0"/>
    <dbReference type="STRING" id="52586.A0A0B1NWZ0"/>
    <dbReference type="HOGENOM" id="CLU_067876_0_0_1"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="243" mass="27909" checksum="B521B5C05F39FBC1" modified="2015-03-04" version="1">MSSTLLSSYKKLWLRWKSLRFPWRKRFLAGLDLHGNTYWEFRDSLNSHQHRMRRIIKYKMSAHHSDIQISPQWHQWLRHTRADPPSLTELSQDILRQEKLRALAAAVDAKWESESKLLVKPGRRQDQLSISTEERDCNAHSVPSPSDTTCTSRENSSSYVKLNGLKLSSHSGFSKHEADPGTSSSLKGSDLITETLSSEGPWTKIHDRFSSCDEWQPKSWDPTPANSTPKSSIDSHELINDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXH4</accession>
    <name>A0A0B1NXH4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosylphosphatidylinositol anchor synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003259">
        <property type="protein sequence ID" value="KHJ31092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXH4"/>
    <dbReference type="HOGENOM" id="CLU_149452_0_0_1"/>
    <dbReference type="OMA" id="PIIREHK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="117" mass="13249" checksum="6A37506DC775658D" modified="2015-03-04" version="1">MAKGARASTRKSKKAKLRCEIFGPEVTARTARLSAKILEIAAQPKPARCTKEIEMEIEDSTKQGEDMEIDSEVLNASTRSKSSRNKIGKRRSYRKTAIVFPKYRKGKKYEKGEKQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXJ5</accession>
    <name>A0A0B1NXJ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dead deah box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003747">
        <property type="protein sequence ID" value="KHJ30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXJ5"/>
    <dbReference type="STRING" id="52586.A0A0B1NXJ5"/>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OMA" id="HVIDMVA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058756" evidence="3">
        <location>
            <begin position="21"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="50"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="268"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="650" mass="73580" checksum="26135043B38DB0EE" modified="2015-03-04" version="1">MSRALQRWTIKLLLGPTLFASEWKFFSTQVTREPFKLREYQEDCVQSVLSNISEGQKRLGISLATGAGKTVVFTQLIDRIKSPDGRRDQTLILAHRHELVEQAARHCSQVYPEKTVEIEMGSMHATGLADITVASIQSIKSGSRISKFDPSRFKLVLVDEAHHIVASTYLKTLDYFGLSTCQKNSPILVGVSATFSRSDGLRLGKAIDHIAYHKDYVELIDEQWLSKLIFTTVKSEADISKVRHGVNGDYQSGELSRAVNTDDINKITVRSWLERCSERKSTLVFCVDLQHVIGLTNTFREHGIDARFITGGTSKSERSERLDRFKNGEFPVLINCGVFTEGTDIPNIDSVLLARPTRSRNLMVQMIGRGMRLSPGKQNCHIIDMVANFERGIVTTPTLFGLDPHVLVEEADPKDLRKLKEKIEKEEARQIIEQESDSTDKKSVKMASSNTKITFTDYMSVHDLISDTSTEIFIRKISPFSWVSVGSDRYILSHINGSYLSLEYSTTDDFFTVKEIAVLSSTKKKLKFARPREILKTPDFQTALRAADTYANSKYIKRFILNSAKWRSREATQGQIDFLNKFRANDDQLSNTSLTMGKASDMITKLKHGARGNFAKLEMERKKRVKELERKEKEIARKLEEKVVAGPIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXP2</accession>
    <name>A0A0B1NXP2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003180">
        <property type="protein sequence ID" value="KHJ31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXP2"/>
    <dbReference type="STRING" id="52586.A0A0B1NXP2"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="16246" checksum="37C53891D99AA272" modified="2015-03-04" version="1">MSYPIQKSEQEWRAVLSNEQFRVLRKQGTERPFVGKYDKHMPDKGIYTCAGCNAPLYKASHKFKSGCGWPAYFDSIPGAVTRHTDNSLGMSRIEIVCSNCGGHLGHVFKGEGYNTPTNERHCVNSISLNFSADDPVTSKISKDNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXX9</accession>
    <name>A0A0B1NXX9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003101">
        <property type="protein sequence ID" value="KHJ31232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXX9"/>
    <dbReference type="STRING" id="52586.A0A0B1NXX9"/>
    <dbReference type="HOGENOM" id="CLU_022625_0_0_1"/>
    <dbReference type="OMA" id="WQPGANR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="65617" checksum="D2CE244EEDD9C30D" modified="2015-03-04" version="1">MENAFLPKELAEVIATRQRRERAWHVRVMICTTVLSNIDSTLASLTEGIEKEETESFKAYLRVAISNFAAAESAMEKENEKEKEKETVNNLPKKVAIATPRIILSQATDRGINKEAKLPITPLSGDNSWAAIARNGQKKARVTLNNNAQAASWKATQSLSSKHKPTKAALTDKRLFVRLPLEHEWRKLSPSGIREVIVNKLAISPSLLGKIKPVKSGFALSPCSTEARENILNAGNGLFLTGAKLEPATNWIPVILPTVPSSIRKVQGQMEVSSAMLIEEVERVTSILPAHVKLFGRNKAETPHRTWMAYFSKAPRTGFRVFDESGIARPFKKQQPIEFCKRCNGHHPTKNCSSAPSCGNCGSTNHSEELCMAATKCRNCGGPHRSDSRRCLARPIRLGAPTKEQMKTFRQVGEREYQAVLRAKAAEESANSAENINIDLTCSQDPEVDGDIDNIPATHIENSTDVLLIQEPWWSNRTKTHPYYDLYLPFGGENVRSRAATFIRKDPKRITSSQKYPPSPTGDYCWVEVNDVMFLNVYKAPHDLTAVQPLLNWTPPPRSVAIGDFNSVYWAWQPGANRYYGQGEEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY20</accession>
    <name>A0A0B1NY20_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003053">
        <property type="protein sequence ID" value="KHJ31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY20"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="499" mass="55476" checksum="6B45AE6286BFABF6" modified="2015-03-04" version="1">MSPQTPHIPNIPQSAQTSPSPPPVVPPDPPPSTITPSDSIAPQRPIIMAIPPSKRASSQHDGRQVQPSPNKHMNIDDAYLPKEITEIIAARRRQERAWHIRLSICASTLSIYKEDVEREEAELIRKYLREAIACLATSNNAPKPPKIPIATKPNKMKSSNKTNTLKQNKLLIATPKHITCPNLQNVQAEIVEPTRPQKQKEKSWAMVTRNGLKKSRISTPAVNPQNEISPNDVIHLTSRPKTNNKDLGKKVKVENKSDNRLFIRLPLDHEWRKLSPAGLREVIVKSLSVFLASIGLIKPVRSGFALTPCNMKFREDLLSAAGGLFMSGASLEPAPNWIPVLVPTVPKTIITVDGQVERSKLMLMNETKRVSSKRPALVKLYGTANPEAPHRTWLALFSEAPRCGFRVFDESGITNTFKKKLPIEFCKRCLARPTRYGKPTKKQLDAYRRAGDREYQAVVRANAAEARAAIAENTEGANETSSRSQETIISVENPNETPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYN3</accession>
    <name>A0A0B1NYN3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sprt family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002842">
        <property type="protein sequence ID" value="KHJ31502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYN3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYN3"/>
    <dbReference type="HOGENOM" id="CLU_447031_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="353"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="611" mass="69332" checksum="0B119EFABFD9048A" modified="2015-03-04" version="1">MENLDSDEDFPNLSDLAKQIKDFPRGKEEISLENVRRADEKNSLRLDERQPKVKIKETKTKTLPVGPQKRLSRKPIDGSDQNPLIGVRTRNKTVESSFENPTQIAETGTILVFPGSIFIKPLDNLSDKNDLGKVPQKGKKKSQNVSGLNQGNFDIDSEINIRPLDFDNFKKFFSEDEYISESPSKNIANEKIKANQKTDKKISRNQSIQGQQISKRKISLKTSSEMITGSKELEKSKNMMDKNRLVRLSPQSTMEGRTILASPKKAPRIPLSPHRVSSDAFWQQDIITEWNDRFSPSKILFPTSSLSACNDKLENPRLLLHQVKILAKADQKSRAAKKQFSEKKVILAESFLLELDDKITGGEISRLAASSGGVKITWNKKLNSTAGRANWKCEKVRSKNLLSDDEPPLLEIIHHAAIELAEKVIDDEERLLNVMAHEFCHLATFMISNIKTNPHGREFKSWATKCSKHFADRGVHVTTKHNYDIDYKYVWKCENCGVEVKRHSKSVDPIRHRCGTCMSKLVQIKPVPRSNFKTSEYQTFVRENMKTIRENYPGSPQKEIMSIIGKKYQEIKASRADKKDSPAQVGNSVVDSVKDKSIDFVAENLNNLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ74</accession>
    <name>A0A0B1NZ74_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative vacuolar protein sorting protein vps66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003041">
        <property type="protein sequence ID" value="KHJ31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ74"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ74"/>
    <dbReference type="HOGENOM" id="CLU_048121_0_0_1"/>
    <dbReference type="OMA" id="WFRFLWD"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="37871" checksum="8BAA8A7E06E1CFF3" modified="2015-03-04" version="1">MEKYSQFRDRGSGVAPFFPIKAKSSGKYLPIYILLFIVKFPFIIIAAIYFLLLQWLPLAPVRKAMLWILLGIPGLWWIELQIDGVRKGSLAKKHAGRIPGPSDVIASSFTSPIDALYLAAIFDPIFTISYPHTEKVQIVSLLSAIFRALAKPEEYPPKDAKMTDIKTIVADNQDRAVVVFPECTTSNGLGILRLCPSLLTVSSKTKIFPLHLRYTPPNITTPIPWLYFSFLWNLLATPTHSIRVHIAKPLYNNTPSQVNSIGHITITSSEIPLKKTTEMNTIEGRSNYMVKQTRIDSLEEKNVLDKVGNSLALLGRVPRVGLTVRDKIKFIEAWRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZA9</accession>
    <name>A0A0B1NZA9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005586">
        <property type="protein sequence ID" value="KHJ30026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZA9"/>
    <dbReference type="HOGENOM" id="CLU_1628277_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="18672" checksum="EEF54DA1D503D13C" modified="2015-03-04" version="1">MFLRIRLPQHIFRVSAPPMLPYDGKASNLRTFCSQLLNLFQDQDVSFPTEISKVRYAYQCLGPGALLKIRTHFRCLEDPSVRPKITSISKFLDALKRESGDPGLVYKATRAVDEMSQKNMTFHDFITKFQDNLVDSTYHDTGECSETELLVSVYLCDSKLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZR2</accession>
    <name>A0A0B1NZR2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative transcriptional corepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005298">
        <property type="protein sequence ID" value="KHJ30074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZR2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZR2"/>
    <dbReference type="HOGENOM" id="CLU_006762_2_1_1"/>
    <dbReference type="OMA" id="HAIMTSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056413">
        <property type="entry name" value="TPR_CcmH_CycH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23914">
        <property type="entry name" value="TPR_CcmH_CycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cytochrome c-type biogenesis protein H TPR" evidence="11">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="917" mass="102668" checksum="519363D71082B085" modified="2015-03-04" version="1">MATHHPSTPPAGMQLLHGPPAGPPPGIPPTQFSFPLAQQLMAANETVWLQIGSLAEVLNCPEEAMNAYEHALRANPRSTQAMSAMSGILRSQEQFLKAVEYLQNILKVEPNNGEVWGSLGHCYLMMDDLQQAYTAYQQALYHLRDPKEPKLWYGIGILYDRYGSLDHAEEAFSQVMRMQPDFEKANEIYFRLGIIYKQQHKYHQSLECFRYIVALPPAPLTEEDIWFQIGHVYEQQKELENAKMAYQRVLDRDPNHAKVLQQLGWLYHQQSQSFNCQEQALEYLEKSVNSDPSDAQTWYLLGRCYMAQQKYPKAYEAYQQAVYRDGKNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPFISEVWYDLGTLYESCNNQISDALDAYQRAAELDQNNPHIKARLQLLRNQQASGIPIQTTAPVPQDVHPQAYQARGAVGPPGPQWGNSGAPPPGPPNGPPNGWGNRLAEITSTSHSSNLFEQRDPPRGQSRPTLQQPSRGPMSPLSGPDQMRPFSGPSPRGPLPPTNSLSIRSPHDHHAIMTSHPGQGLTQTSAQANQLNNSHHHHHQQQPQPPPPPPPQPQPQPQPQPQQQQQQQQQPPPPPPPPPPQQQQQQQQQHQQQSQQPQLQTQPQPSFPRVYNPNYAGPGAANNIHGLTNGVNGVSLANSLPPFARNNSPRTEGRVLHDSRMSSPKPGYPLHTSFQHHSEIQHHIGLENGGPVSVSALTSVEAATAERNGDHIRPGSVGAKRLREWDEEQSSMKKPASDETRARLMDTHHRRQSTPPRDSAFRRSSSEVRRIEEQRIPAHEILPPPPPPPPPPPPPQLSSKEYPQEERERERHDHLSPICHQTGEAERAKRKMVIDEDYDDDGDDDKKPIGLLTNSGSVSVAGDIKTTSPSGVNGHTVNGVANAQPKLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW7</accession>
    <name>A0A0B1NZW7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01002487">
        <property type="protein sequence ID" value="KHJ31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW7"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_0_1"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="378"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="550"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="701" mass="77792" checksum="A8CDF7722648EA23" modified="2015-03-04" version="1">MCGIFGYINYLIEKDRKHILETLVNGLSRLEYRGYDSAGLAIDGDEKDEVFAFKEVGKVAKLKQLVQESQLDNSKVFDSHAGIAHTRWATHGPPSRLNCHPHRSDPKWQFSVVHNGIIINYKELKTLLISKGHKFETETDTECIAKLAKYIYDQHPTITFTDLAKAVIKELQGAFGLLLKSVHYPHEVIAARKGSPLVIGVRTEKRMKVDFVDVEYTDDGALPAETASQNVALKKSKVGSSTSVGNLLAPADKSLLHRSQSRAFMTDDGAPMPTEFFLSSDPSAIVEHTKKVLYLEDDDIAHIHEGTLNIHRVTKTNTSSSVRTIQTLELELQEIMKGKFDHFMQKEIFEQPESVINTMRGRLDVENKKVTLGGLRSYIATIRRCRRIIFIACGTSYHSCMAVRGTFEELTDIPIAVELASDFLDRQAPVFRDDTCVFVSQSGETADSLLALRFCLERGALTVGIVNVVGSAISLLTHCGVHVNAGPEIGVASTKAYTSQFIAMIMFALSLSEDRSSKKQRREDIMEGLGKISGQIKEVLKLDQPIKQICARTFCNQKSLLLLGRGSQFATALEGALKIKEISYLHCEAVMSGELKHGVLALVDENLPIIMILTRDSIFPKSLNAYQQVIARSGKPIVICNPNDDEFKSEQAEVIEVPKTVDCLQGLLNVIPLQLMAYWLAIAEGLNVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P043</accession>
    <name>A0A0B1P043_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="JNVN01003795">
        <property type="protein sequence ID" value="KHJ30655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P043"/>
    <dbReference type="STRING" id="52586.A0A0B1P043"/>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="666" mass="76654" checksum="4406D5F2F5946D09" modified="2015-03-04" version="1">MGLLALGTPLDWPEAKVKADIVRQWGVQQLLHIWNKAKSKESDVLLWGDEIEYLVVNYRADIPKVTLSLRQAEILEILAEAKKSKNYGSNGDTQSTSKQNDDNIDTAFDPNFHPEFGRFMLESTPGKPWGIDFKHLLEVESSMRMRRSMAKAHMLPEEYPITLTTFPRLGTPGEFTCPYYPISGDRIRSQFVPDEIANPHIRFPTLAANIRSRRGQKVQINVPIFRDTNTKWPWNDPTVNFDLHRWPEDDDVRNGAVLDNHIHMDAMAFGMGSCCLQITFLAKNIHEGRLLYDQLSPLGPILLALTAATPIYKGFLADTDVRWNQISASVDDRTKEERGEKPLKTDRWRIPKSRYASNSTYISVDSRLRQEYLDPDLVFAPEIRKLLMDGGMDSLLATHFAHLFIRDPIVIFAEDLQELDLDKTDHFENFQSTNWQHIRFKPPPADNSIGWRVEFRPMEIQITDFENAAYAVFIVLLTRAILSFNLNFYIPIQKTDENMQTAHKKDAVIKEKFYFRKNPFDTKQTDFMTIHETHSTPNPHQPSTKLASIEDEYALMSIDTIVNGSNKDQDGNFPGLIPIVENYLDNMNIDFETHCKLASYLDLIRNRASGSLWTAAKWIREFVRDHEDYKADSHISDQINHDLIQAVLALGMGNRDMVKNVEHFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C1</accession>
    <name>A0A0B1P0C1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01004483">
        <property type="protein sequence ID" value="KHJ30321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0C1"/>
    <dbReference type="HOGENOM" id="CLU_056023_1_0_1"/>
    <dbReference type="OMA" id="VWHATEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="45580" checksum="15ACDB8F482EE5FE" modified="2015-03-04" version="1">MSMPQTEVEQFRSKPLPPGRANLTDAHYYSFYQNQVVFLTGGTGGLGGCMLYKLILKLHTKKVYVLCRDIAKAHRTWANSMPNQYQKILNSGRVVLVEGDILKKNFGVDVSQILDTTIVINAAADISFAQELDDAIKKNCLPPLELAQMASQLPNLKCFIQVSTAYCNSFLPDGLVEEKIYPLGDPEEELQTKANADKFPWSYAYSKHLMEQLLFSRNPNLPILIVRPTIIGTAVHQPYPLYGPMGSTPLESFFKFFTISPGNRVFHATDGSDTGTNIFDEVPVDWVANLTLLHAAAGTRGIVHAGSESYIPRTLDDMLRVAKVNNADMEVRFVKDRSIEQCPLAAFYKVASRDWRFSNKSSAKFRGVEGPLSISVKGIDLFEFDCHRVSKLNNMLEKYRQPVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H9</accession>
    <name>A0A0B1P0H9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycoside hydrolase subgroup catalytic core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004560">
        <property type="protein sequence ID" value="KHJ30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0H9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0H9"/>
    <dbReference type="HOGENOM" id="CLU_022442_0_0_1"/>
    <dbReference type="OMA" id="WPRWCGK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061687" evidence="1">
        <location>
            <begin position="22"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="576" mass="65639" checksum="A9D0E8E08754E561" modified="2015-03-04" version="1">MSLVLIWVGLLLLWASQISQCQYQTWCGKVYQKQYPAVIPDGTFEYPVPKPFQMLYLDVKSRYTIFLENDPAVELIVEAAYSNIFGTPITNDSNSILSETLEIGIKCDETGVTLNNTLIPIESKKNIVYFDIKLLLPRLEPYQISVYGKLSNSKKLYSANTEIYVLPARDYGSAVKIDRLYGGSLVQNSFNQYTGWYSVFPHGMFADSKVTIPTTINFTYLRSYADLGFNMILIVPDGAAPEQSYNDQELQIYWDAMDEMNLLNIYSLQFAYQNQTRIETQVNMWKNRNTSFSYHIADEPDGWHHPVENTRLAYDQIKKLDPYHPVQLVLNCQNFHYTEYASGADIILEDAYPIGTSPYHSIIWDTPCNSTYGDCGIDNGNGELIDVANRMDSLYSYQTHIENGGWKPMWSTIQEFEKQDYWNRQPSTKEVINMAMLSINHDAKGVLYWLYTNSNDQGVRGAQMVASILKNHEITRFFLETMAINDLLVEGHSMMDVSAWLLEDQLLIGIVSFSSTSSEQEMKIILPSNIAITGILQQPFGSSYFTLVDNTLSTEGMKAQEVNILIMSVQPSKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J4</accession>
    <name>A0A0B1P0J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative chy zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004253">
        <property type="protein sequence ID" value="KHJ30436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0J4"/>
    <dbReference type="HOGENOM" id="CLU_013368_4_3_1"/>
    <dbReference type="OMA" id="METQFRN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="311"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="380"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="709" mass="79944" checksum="DF466D482E2F377E" modified="2015-03-04" version="1">MSNLVNDFLIEPVLRRARNFSRSNIDSINNEQSISTNRSDVAAKNPDRSLRVQEVLNEAVKTKTKEVAENPLISNSTWLSTQEDETLENAFEKRDNVGQSSGILLPQNSSAIQDITYYLDSESGSSVVPEDLSDESTMLSPDTSTSAIIDHVEGNFEGGSIDLIERRTNSMELSEESTISIDHPRTTPLPENDGMGQLRRQIISIQAMDIKPERKARLMHQLLTRNYSKAQKQSNARKQRKLLSPSTVIKQKMSTPSGSLSYFLWQLKSTLDLAMEEQNYTYRLSPEDIKPTYVPFDNEELEDNLDVGNYDDFRVLGCKHYKRNVKLQCSACEKWYTCRLCHDEAEDHVLDRKATKNMLCMLCGSAQKAGEFCVECGKRTAWYYCNICKLWDDDPNKNIYHCNDCGICRKGLGIGKDFFHCKKCGICMSMSVEHSHKCIERVSDCDCPICGEYMFSSPTPVVYMLCGHGIHKACYKEHLKTSYKCPICNKSTKNMETQFRNLDLAVASQPMPPQFRDTKALISCNDCCAKSAVTYHWLGLKCAICDSYNTTQLFLMSGSTEGIENQVGNINDDSPSNFGSRDESSAPISVSSMIRRRHSSYINSENSDSHSHNGTLSVQGHHRASRSISPTRRSISLSDESIYQAIETDDSGGEEDELDFWGLDESRSITSGEIDEEMDEDESDEDSIPEDCDDDGDDEEDDFTLFGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q9</accession>
    <name>A0A0B1P0Q9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01004301">
        <property type="protein sequence ID" value="KHJ30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Q9"/>
    <dbReference type="HOGENOM" id="CLU_022618_0_1_1"/>
    <dbReference type="OMA" id="PIMIKPQ"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="279"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="59672" checksum="3118A90CAF2F52EB" modified="2015-03-04" version="1">MDVGDSSSQLHDSKANYQNATAASRRAESSIYSNQVPARISSSRTYEEPSPLSPVSPSKVHSYEDAFPIGGQQFRFHDDQSTSSYDSRIYGTQIQRPILSDSYTDNIPLRDNLAFLPKKENLSDHIYDAPANKPKFSGDRELRNKSGFLSFLNTKRRIPWMTYTLTAIQCTVFIVEIIRNIQLTGSPIEFQPSFNPMIGPSPYVLINMGARYTPCMHAVNGLQTRTSGGEVNWPCPNTTSNDVANCQLNNLCGFNMSPMQNPVYPGQNIPLNEFPNQPDQWFRFIIPIFLHAGLIHIGFNMLLQMTLGKEMEFSIGSIRYFLVYMSSGIFGFVLGGNFAASGIASTGASGALFGILALNLLDLFYTWGERNSAFKDFTYIMFDIVISFVLGLLPGLDNFSHIGGFFMGLALGICILHSPNALRKRINEESLPYTPVSQIKTTFNDRPDFSLTSSIRNPLDFFRGRRIAWWVWWIVRVGTLVSVFIVFIILLKNFYTLRKSCSWCKYLSCIDINNWCDIGNLQLTTISRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0R0</accession>
    <name>A0A0B1P0R0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002230">
        <property type="protein sequence ID" value="KHJ32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0R0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0R0"/>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="753" mass="86306" checksum="5CFC6CDA15B1C04E" modified="2015-03-04" version="1">MLKHKPSIKMAHGSVEIPATNVSPRGGATYSQEELGEILEYEKILQFRDTILAGRHPRVRIQTHSQLRSIQPDFKSNSHLLAHTGPSSSSNMTETMPVVNEGQINQSTSSSANIFSASRPTMSRNLEINPVLLEKSDDLIKAEIQLQRQRLERGLREQVEHQRHAARILLQNSEQLPDFDILEALAKAFEIVPHVSIADNESSSTYGSSGSKSFDENTFYSSLNESPIPSISPEDQRNFCNQNMASAINRFSSIENLRDVTYEPATSNVPPRRIENYGAMDNGLNPPLPTSVKPKERQLENNMTHYDTSYKENFVERERPVITRLDPREAGNTAMRKETNLFEYPMGKTSDSYQRYPKQGFYNEPTPAQFRNHNLPLVAPQPERVSPLPIASDSLILGAINGRHPSQVSALRHLPAFSSADTSPRNKLNEKKRDKKKRKVKDTSTPDSPYIKTEPKSPSLHIPFPSYKRQRSQYDSEPNYERPRPASNIQLQERMADTSRWPFRPQEQGMPYDSVGYDSRYGHNESTNVPQRISSAIPIRRPYSPQYFTPYLPSETRPRAVSNLVGGRHFEDRDYISEPITRNSVRPNLDSERARSPLHHNTQPGPLRKYLVDEKSGQYFYFSPTSIAGDPIASKVRYHDEDVAYERVPKRVVSNRVPNENYDSDNYLRYRRSPISNTYQMPIDNYENDNYLRQRRSPLPSAYRRVMTQPEYLTSPIPNQRSSRQRGYSVYPTLASTHVEEHDSYRVAQDYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P154</accession>
    <name>A0A0B1P154_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003819">
        <property type="protein sequence ID" value="KHJ30646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P154"/>
    <dbReference type="STRING" id="52586.A0A0B1P154"/>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="OMA" id="DYIPKRK"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="22080" checksum="1EC40C8D5965F848" modified="2015-03-04" version="1">MTTILQSITPRPYSLVLRRVFSTTSLPIPKVKKLPQKGNIWESVPRTSLAYEKLYRPIGIAAFHRSRRNSILPPLPQVINGTANDPAPIPSPDPTHGSYHWTFERLISAGLIPLTIAPFTVGSLNPAMDAILCATILIHSHIGFEAVIVDYLPRNRVPNARKFFWWTLRAATVAVGVGLYEFETNDVGVTAAICKIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H2</accession>
    <name>A0A0B1P1H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative upf0667 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002359">
        <property type="protein sequence ID" value="KHJ32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1H2"/>
    <dbReference type="HOGENOM" id="CLU_060603_1_1_1"/>
    <dbReference type="OMA" id="EKKLGMA"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="89"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="214" mass="23780" checksum="F0C05B55957AEF56" modified="2015-03-04" version="1">MSSDIANVLVTSFPGLGLPSTLSLPLSTETTINQLYSRINERLPKHDSRLILTTTSNKQLSNISTNLISTLLCPVSDLICLRLSVPLCGGKGGFGSQLRAAGGRMSSKRKRGQGDENASSRNLDGRRLRTVNEAKALAEYLAIKPEMAKREKEERRKKWEQIIELAERKDDELKSGKKQRVDGKWVEDKDDAVERTRDAVINAMKNKAQIVNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M2</accession>
    <name>A0A0B1P1M2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003719">
        <property type="protein sequence ID" value="KHJ30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M2"/>
    <dbReference type="HOGENOM" id="CLU_1751057_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="17058" checksum="A3C321C3F345835D" modified="2015-03-04" version="1">MTARPKKPQFLTGGDSGIKCWDRVYDAEYIFGIFDLYDTPEAPGRSGWEWGSGNFYPKPYYPNDMGIRFRVRGPYRMFPLLPDNKIWKIGDPVQSDFVIVTEIFKVVGAISISYGPNKKEIHHKCEMIHNPENYSAGGRSGENEFPQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P202</accession>
    <name>A0A0B1P202_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mrna decapping complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P202"/>
    <dbReference type="STRING" id="52586.A0A0B1P202"/>
    <dbReference type="HOGENOM" id="CLU_008108_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="94"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="674" mass="76447" checksum="F2953D911A3B27BA" modified="2015-03-04" version="1">MERNMQLQDWLDDLCVRFLMNGPKEDLETAERICFRVEEAQWYYEDFIRPQDPTLPSMTLKCFCDEIFAHCPLLLPFSQDHRMKAFDAFLSYKKRVPVRGAIMLNQNMDKLVLVKGWKKGANWSFPRGKINKDEDDLDCAIREVYEETGFDLGEAGFIPADRQVKSIELNMHEQQIRLFVFRGIPMNINFEPKTRKEISAIDWWQLSDLPAFRKGKAHIQQPVYKVTNFYMVAPFLAHVRKWIAEQKKLDANRMMDGKYQPEKALWPDEATSEEEQMAESSTKIISREKEPFTTDTRSSLKEVAKLNNLMDDIRSVGLTHERTTDPPVNDAGSALLLLLNSKTEAAINQRPNYSTQNKTENVPVSDNGSALLALLNSKASIAKNQRINYLPQTPTSHKNLQSHTPITPLHDQTPNASLITTMLPSPKISVPRQDENSIHYHQQLIKNQYDSVADIKKKIQSNQYSSITSFNPHPHPHPNTYQHQHLIHPQPLPPNVQRTVFAQSPMSASPLASKALHQSSTSKMPQIPITGTTSIPGVEKNMSPKFTYNKISLLNSIKGHNHSLLSEVNIKPNSEIGMGSKSSKGFTLNYTQEANHRSNFLPLQIKKDIPSTLSGLQNDQLSQISALNGYPKPRTSTIVSDVPIRKKGSQSISHSDKQFLLSYLDAVVAKGINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2E9</accession>
    <name>A0A0B1P2E9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pseudouridylate synthase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003244">
        <property type="protein sequence ID" value="KHJ31121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2E9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2E9"/>
    <dbReference type="HOGENOM" id="CLU_014673_2_3_1"/>
    <dbReference type="OMA" id="SCRERRY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="353"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="634" mass="72817" checksum="339A2B5CA3D10944" modified="2015-03-04" version="1">MQSAIEPESQFLDLKQGRLDEKDHDEIDYTSWSRSQLISRLIELEQCQKKQQQQKFKNEKIIEPKIKLQSSLIDIEKSSKRLHGEKRSESRPFDPSKYNTRLVAFKLAYFGKRYSGFEYHAKTPTSLPTVEEELWKAFTKAKLIFPHPNQAVGDWGGCEYSKCGRTDSGVSAFGQVICLRVRSNRPLGSKSSEESFVKDKGEIKRDTEPYCYLENRPQKIEMPVIYSTLPRDSLVELAPEHPNTSRIQSNAIDFTRKEEDANFEQDVTYDPVADELPYVAILNRLLPLDIRFLAWCPAPPLNFSARFSCRERQYRYFFTQPCYMPLPNSIDPFLNSNSTTKDGYLDINAMNTAAKLFEGLHDFRNFCKVDASKQLESFVRRIYYAEIKEVPDTTSTLEILNSSDFQLPNHSLNSGSPKVYAFILHGSAFLWHQVRHMIAILFLIGQGLEEPSIITKLLDVTKNPRRPMYQMAAETPLVLWDCVFPHEEDTERREMLQWIYVGDTPGTADAKYGIPIGGLMNDLWQTWRERKIDEILSANLLGLIAGQGISLLNLKARSIGKGKSQKVFDGSERPKLQGKYTPLMMRPVMDTVDIINQRYAIRKGFESSADMKQQGFRRLNNPGPDHNAQSNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P393</accession>
    <name>A0A0B1P393_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003204">
        <property type="protein sequence ID" value="KHJ31149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P393"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="148" mass="16665" checksum="8CEC0D7159D633EF" modified="2015-03-04" version="1">MAFFSKASHCGFRVFGESGIARPFKKQQPLEFYKRCNRHHPAKNCSRAPSCGNCGSKNHATDNCLAATKCRNCGGPHRSDSRKCLVRPTRSRAPIKEQMRIYRQAGDREYKAVLRARATEENAVSIEKMNAELTSSQLQENTKTTDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L8</accession>
    <name>A0A0B1P3L8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative acyl-dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002462">
        <property type="protein sequence ID" value="KHJ31930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3L8"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OMA" id="LAYMYAM"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="257"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="447" mass="50150" checksum="834CD2BFBAE1D34C" modified="2015-03-04" version="1">MADLIPTLAASKVSQEAKKTLDLIKWFVEEVCIPADPVFNAQIEHANRWDDHESIIDDLKRQARDLGLWNLFLPKGFYKESPGFTNLEYGLMAEWLGRSRVASEAVNCAAPDTGNMEVLAMYGSEEQKRKWLQPLLEGKIRSAFLMTEPDIASSDAKNIKMNMRKEGDEYILNGDKWWSSGTGDPRCKVYIVMARSNPTNQDPYKRHSIILVPTDSSGIRINRMLSVYGYDDAPHGHGHLTFNNVRVPATNLILSEGRGFEVMQGRLGPGRIHHAMRTIGAAERALDLMLLRINDPRKITFGKQLKEHGVILEWVAKSRVEIDAARLVVLNAAIKIDEHGAKKSIKEIAEAKILVPKIALKVIDRAIQSFGAAGISQDTPLANMWAQIRTLRFADGPDEVHLNQLGRNENKRGIEASQKITAQERKTHELFAKYGVTPIKLGPRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V7</accession>
    <name>A0A0B1P3V7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secretory component protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002719">
        <property type="protein sequence ID" value="KHJ31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V7"/>
    <dbReference type="HOGENOM" id="CLU_080510_0_0_1"/>
    <dbReference type="OMA" id="ANMLFDG"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="230" mass="25447" checksum="FCD5F2D35C0FEEFB" modified="2015-03-04" version="1">MPEISKNTSSSYESPRGHGGSGVRGVSSFATFMIISSVCFFLGMLFSALPYDYPLLWTSDVTPDAYYDQLEMHLRFIHASPPLISRMLHIVIGIGFFGLFIKLFKPSEANLLFDGASLVLYVVGVIVYISNIVKGLRIVTNGSYGADEIDSSLAFGRVDSLKVLAASNTILALMLVGILVLQAGQWYAERKDHDETARFEREEEMKVLATRGQRTLSVSHTTKSHSKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P426</accession>
    <name>A0A0B1P426_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002930">
        <property type="protein sequence ID" value="KHJ31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P426"/>
    <dbReference type="STRING" id="52586.A0A0B1P426"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="OMA" id="HINIREH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="207" mass="23473" checksum="191407937D20F6DA" modified="2015-03-04" version="1">MARFMCNPSPKHHQHILRVPQYLSGCLDRSLLYQKNHRHVSDFGCYGLHCAVDASFADEYDTAKSTTGYVIFMAGSPVIWKSKLQSTVSTLTCEAEYAALFEAIKDCAWIRSFLTELNQMPNGPITVLEDNTGAIKWSTDDGMTSGRRRVRVQYHYVVQEVRDGNIKIQQFQSELNPADGFTKPLDGNSFRRFIQHLGLKDGIFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A8</accession>
    <name>A0A0B1P4A8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002277">
        <property type="protein sequence ID" value="KHJ32165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4A8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4A8"/>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="35475" checksum="4E0B3A2E5A282F43" modified="2015-03-04" version="1">MSLTNCRFYEEKYPEIDSFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRIGRNEVVVVLRVDKEKGYIDLSKRRVSPEDIIKCEERYNKSKMVHSIMRHVAEKTQHPIEDLYERIGWPLNKKYGHAVDAFKLSITNPDIWQDVSFPNDVVSEELKSYIGKRLTPQPTKVRADVEVTCFGYEGIDAVKTALRTAEARNTPDNQVKVKLVSPPLYVLTSMCLDKSIGIQKLETAIDDIRSNIVSAGGSCAVKMEPKAVTENDDVELQALMEKRERENAEVSGDESLSESDENAVETQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4J7</accession>
    <name>A0A0B1P4J7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bactericidal permeability-increasing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002742">
        <property type="protein sequence ID" value="KHJ31604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4J7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4J7"/>
    <dbReference type="HOGENOM" id="CLU_013290_0_0_1"/>
    <dbReference type="OMA" id="PRYEDDT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="1">
        <location>
            <begin position="238"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="743" mass="84799" checksum="9E7C4DD40F24EFAA" modified="2015-03-04" version="1">MSRWGTRNETSTDDQEPLLAQYDDETVLQKEAHRKMHSYQMIRALFKGYLPSNEQIIINLRALLASDFLNPDTIGWGNSSQILIKDFKQWIMRFIQFLKNKNEEDQIQNLIYLLIHARVSVETGDITQKISGVKSKADTLAVFESIRTIGSLLLTNSEMREFLNDLNSIGRQVFIDVSHTVSNTAEAMANKVEKSNDAENYNNKYGDAKEDEAIPHNLDSNIQGIGSIMSHGATETGVEVKAKIKENFSGEQRKVLIHRLKTAVTKLRQRNDYSDSIKIVSLLIRQYSEIYSRAANQAISVVQNDINTNESLELAMKIIWSFSSSFGDKEVWIELQTRFDKIMEHSKNDPDFELFCKELSNIFEQMFTDPCFFDSVIEKFNTIKLDIENIGTNGSLSKDIKSLLDQIRVALISVANDQDVSQLLETTVSIFATIFQHDNIINSGLITDMYSIFMPNFIQAIQYIPIPRLEISGPRADLLVENLIIEPGHTINHSSFLPFHLKIQLFNELNLHKARFQTVSALESVVKIRLQGISLRAEEVGYWLRTQIGPFSFTDEGIASIEMDKRGMDIELEVEIGKESLEKILTLKDVHIKIHNFTYNLRKSKFSCLAWLLKPLIRTTLRGNLERQLTKSMSDFFHAANRELLFARERLRAARISNPQSLHTFLEAVLTRLKPKDDSDIQAHIGIRGAAHDRGNVFAGRYAPGSVVKLWDREVTRVGDLVNENSGAQIWRNNIFDVQVHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P2</accession>
    <name>A0A0B1P4P2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative serine threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P2"/>
    <dbReference type="HOGENOM" id="CLU_000288_46_0_1"/>
    <dbReference type="OMA" id="SPWIDFY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000652">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="61"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="949" mass="108607" checksum="F73297655794F3DD" modified="2015-03-04" version="1">MEALSPRDVNANIRNNHNVKQIVKSSTVPVKITHEEKDHPPPPPSEVIEPKGINQKCGVTYKTGQLLGRGGFAVCYEGQNTATYQKYALKIVKSHMPQKKMEQKFQTELQIHSKMNQANIVEFHKAFSYQKCTYIVLELCPNGSLMDMVKKRKYVTEPEVRFWTVQMAGAIKYMHGKGIIHRDLKMGNIFLDKNMNVKVGDFGLAALLMSGKDLQACRRTTLCGTPNYIAPEILSKDKGGHDHAVDIWSLGIIIFAMLTGKPPFQSATADEIYRRARERDYYWPKFNTSENIISEETKDLVSELLQAPQERPEPDKIVQHAFFTCGWTPKAEEMTTSLREKHPNEFQFSSIDREDKMASSLQNLKNICIQCEVGPWTLPRKYTSTYREVEEEEKLGLTPAVPLVEGVVYRPFHIWLQEQMVNFKNNGESTVNILKLLKEVVSPLPRKNSKNGNSLRSSNRIGTTQRVKSQKLNSQAQIGEEKKNNAAFNISKKKSTYKLNKSEPEAKQDVNDQLAVNMFNKLDINDIKRDHRRECEANSISREPFSIFHKKDGVKVVPDSKPDFILSRLRRLQDELERSLGSRSFATDSHIPKETPVIVVKWVDYTNKYGLGYILSNGSVGTIFKAIPAFPQDPKKGLSPPSCVLVRDSEKHLLNQNNPNWIDYGQLVPVTGHKIEFYENRGDQGFFKAEVDAVNFKSIPGLNGEMFKLGIGRDEYDSRKKERIAIWRKFGNYMTQYGRDTDYPYDRNSDAYPEAESSAANFVNFYQRWGDVGCWGFDDGHLQFNFPDHTKIILSADGKWCDFYHLSLEAAQDLHEKGVLSPQALDERQHLSYPLQTILNFTARTIRTRSNRLPEIDPMILDIPQANDFRRKIEFIVLCIKEWTTNGGMGISDLSVKGRLRWNGARQRIDTKAPYKQVWVCVGGRATEERKVMWFDPRVPDLISPDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Y3</accession>
    <name>A0A0B1P4Y3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001519">
        <property type="protein sequence ID" value="KHJ33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Y3"/>
    <dbReference type="HOGENOM" id="CLU_748404_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="345" mass="39479" checksum="F7864B1CC7B334B4" modified="2015-03-04" version="1">MVATIETSIKWCEDSTRKYEDSCLQDEELWEIAFDDLSEAIAMGVVDLETLKPTSNYKSALMNLRGVLRRKGVYICRKAGKKITDCFSEFLQTSTNGTVPVWPLESLKSLINSEVTSIKDISLGLQYLYQKNDVTKDENNKYIAATKMEYKNTGKSRDFISSASPTTMNEPKTPFSMDDLPRILGNISKMYQTEDKKYNGWNDSLDYKMEMYKDICDINQCPLDRRMDGLILALKEPALGEFRAHRHDVGMTFEGMINHFRGCYEGIDFKRSELQAWHTISYKLIKEQNQNKPPSECVVILVDALNAKRRSLDPSQRTDDAMHTRLTNACWKIPEFQSALSAPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5D4</accession>
    <name>A0A0B1P5D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tir-nbs-lrr type disease resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001164">
        <property type="protein sequence ID" value="KHJ33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5D4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5D4"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_4_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="123" mass="14037" checksum="2CBC375EA5ADDF53" modified="2015-03-04" version="1">MSDAAVRALWARICYSRLQGQENSSDVNEKSKEEFPIALLFCDNKAALTLTHGLKSTSAIRHIRTSFHHIVDEVRQGTLCTNWVPGKDMLADGLTKPLGRIQFEDKRRRIGVRDVEKWIDQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J9</accession>
    <name>A0A0B1P5J9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001130">
        <property type="protein sequence ID" value="KHJ33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5J9"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_1"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="392"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="462" mass="50403" checksum="E53DF2F91426A721" modified="2015-03-04" version="1">MASAQNISKLPLSTSFGLSVSNSPGTFLNSPASLNLRHLSATLKQLKPFDAQEIKVLLLENVNQSGLAVLESQGYQVEALKSSLKEEELIEKIRDIHVIGIRSKTQLNQRVLSKAKNLIVVGCFCIGTNQVDLNYAAKKGIAVFNSPFANSRSVAELVVCEIICLARQLGDRSNELHAGIWNKVSAHCWEIRGKTLGIIGYGHIGSQLSVLAEAMGMKVIYHDILNLMGLGSAKQVRSLEQLLNDADFVTCHVPELPETVNMIGAPQLEQMKFGSYLINASRGTVVDIPALISAMKKGKIAGAALDVYPIEPGSNGKHFNNNLSDWIEELRTLQNIILTPHIGGSTEEAQYAIGIEVSEAIVRYVNSGVTLGSVNLPEISFRILQNEPKHARIIYIHKNVPGVLRKVNGIIGNHNVEAQTTDSKGDVAYLMADINDVEDEELKEISESLAELSSHILTRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L1</accession>
    <name>A0A0B1P5L1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g3809</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002454">
        <property type="protein sequence ID" value="KHJ31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L1"/>
    <dbReference type="HOGENOM" id="CLU_097279_0_0_1"/>
    <dbReference type="OMA" id="CYLLCIF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="250" mass="28760" checksum="4DA083A37957EE9C" modified="2015-03-04" version="1">MLHFTDDMTRMNFVYLLSNKTGPNLLRHFKNFVAYAKRQFNKDVKIFRCDQESGLSRSFEDWVNELGIEIQWSSVRTSEQNGQSERSGGVIQAKARCLGNGAGLPAEYWPEFVMTAAYLINRTPTATLNWLLPLSKLRMALEIPDKDEYSHLKAFGCTAYALDKSIPKGEKMRPRAKRGLLVGYNSRNIYRILLLDEEIVIGTRDVIFNENLFLDDHQEQEVEEDSIPIIDFKMICPQPSIIFDDEDVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T5</accession>
    <name>A0A0B1P5T5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002219">
        <property type="protein sequence ID" value="KHJ32266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T5"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="336" mass="36909" checksum="D6BC7F1BC02C416E" modified="2015-03-04" version="1">MTDSMEISTESQAPSTDTSKQPPPIPNSPSPIASTSPPSNTEPQLKPIDSRQILKPVTPSKRSVTERPNQNGKEKPQTQNAFLPKELAHVIATRQRRERAWHARLMICTTAISYKESALENFKEEVEKEEVLAFKAYLRMAIANFAAAENSPAPPQIPSHTRPNKSGGYGSANGKNGLKKVAIATPRAPMGVAAKIRKIYEAQSLPKIPKMTENTWATVARNGQKKARVTPSTTTQVAPVGTKKDKSGIRSPPNKYPSDKRLFVRLPVDHEWRKLSPAGIREVIVKKLSISPTLIGKIKPVHSGFALSPCSSEAWENILKAGKRSLFDRSEARTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P645</accession>
    <name>A0A0B1P645_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002107">
        <property type="protein sequence ID" value="KHJ32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P645"/>
    <dbReference type="STRING" id="52586.A0A0B1P645"/>
    <dbReference type="HOGENOM" id="CLU_031263_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="435" mass="49262" checksum="35B48156BF0C22A9" modified="2015-03-04" version="1">MLRGLALDYYYTNIATHRIASFDQVCDATRKYFEGPEFKRNALSLWNALSFKSVMETDPGKSAQDCLQILVKELGHLQHGLDSELRTNKFLHNKIINGCQDVAAFQLACFKPSETMIGLLNDLRSSIATYEKLHGPIKSETFFTDRRYRNQDPRYLQKSPSSFSPSTLKSQKYVQVKKCFVYHIPGCRFTRHNEEDKDKSIQNYKRKFNKRFDQNARQYIIDFEGKEYEEKVFDDTSDAEIDNERIDALIFDVDTITDNESDHRQYFTALGPIKDAESMAVNLANKSFVHATTKTTPCDLNLSSHVTPQLPSPFSFTSSTTSSRYNSKHFYGIMIDTGASKGSTAGYGQYVACKDNNSNINIDTSKAGLMNVQFGIGSTESIGSFILNTPIGTIEFHVVHADTPLLSLADMDKLKIFYTTTLIMFSSHLMGPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B9</accession>
    <name>A0A0B1P6B9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex, subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001239">
        <property type="protein sequence ID" value="KHJ33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B9"/>
    <dbReference type="HOGENOM" id="CLU_2499556_0_0_1"/>
    <dbReference type="OrthoDB" id="3599996at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10211" checksum="5D14E4C9CC5E1F1C" modified="2015-03-04" version="1">MLRRKPTAITLTNEDIAIYEDARAREAAELKCKEELRERQSSQDQMQRDSDSMLTDQQNHQQNLKDAIQEPTMRERIMGFGNHRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6D1</accession>
    <name>A0A0B1P6D1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mfs transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000979">
        <property type="protein sequence ID" value="KHJ34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6D1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6D1"/>
    <dbReference type="HOGENOM" id="CLU_012596_0_1_1"/>
    <dbReference type="OMA" id="PDGLGCY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="509" mass="55316" checksum="53CB9791400C7165" modified="2015-03-04" version="1">MNLYKERIISSIAATTIALAGGTNYTYSAWGPQFADKLNYSSTEQNIIGLSANLGMYLLGIPIGIFVDSNGARITVLYAGFLLGIGYLILYNTYSNGSGYLPLLCLFSFFTGVGGCASFAAAVKVSALNWPENRGTATAFPVAAFGLSAFLFSSFGQVIVSGNTSSFLLLLAIGTFGLNFVGFPFLRIIKVPENILVPAATGNYLVKRKLYNSKPDETASNSQLALVNEDGSASGSGADETALLLLDATLVNPIDDQESSRIDYDSTLQISGIKLLSQVEFWHLFSLLGIFAGIALMTINNIGNNVKALWRLWDESKDEEFIIQQESFQVSFISIASFLGRIISGIGSDYLLKTFKASRLWCLVFASALFFVAQILAVTLRDPRLLFLISALTGLAYGFVFGCFPSLVSEAFGIHSLSQNFGAMLLSPIISGNIFNLLYGKIYDRQSFFGPNGHRECTKGLSCYQKAYYITIVACLIGFTVSLSSIFHTHRARQTGLKLVNRHENEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F1</accession>
    <name>A0A0B1P6F1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">EV44_g2181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001720">
        <property type="protein sequence ID" value="KHJ32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F1"/>
    <dbReference type="HOGENOM" id="CLU_002096_2_1_1"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="338"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="886"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="604"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1020" mass="117424" checksum="3B5204B2D361BBF0" modified="2015-03-04" version="1">MPPPHQKPENVLKRAHELMGVGQSQAALVLLHEHITSKRSRNAPLTSLEPVMILLVEQSVEQKKGKLAKDALYQYKNISQNSHVGTIELVLKKFIELAEEKVKTAQAKADEVQSSLETTAATASVDDLEASETPESILLSTVSGEQSRDRTDRAIVTPWLKFLWETYRTVLEILRNNARLEIMYQNTAMQAFGFCLEYTRKTEFRRLCELLRNHVQTAAKYSTQMNAINLNDPDTLQRHLETRFQQLNVAVELELWQEAFRSIEDIHTLLNLSKRPPKNIMMANYFEKLTRIFLVAENYLFHAAAWSRYYNLLRQSASMVASGQGKKSDNPATSEADFSKAASFVLISALAIPVISTSRSRGALVDLDEAKKSKNSRLTHLLGMSQAPTRAVLFKDAMSKGLLKRARPEIRELYRILEVEFHPLSICQKISPILSKISADIDMEKYVVPLQQVILTRLFQQLSQVYETVDVEFVENLAKFPEPFKIAKDTIEKFIMNGNKKDDLSIRMDHATGVLSFDSDIFSSTKNSNSGLGSNENETSVQKLQNTPSDIVRTQLTRLTKALYLTCQFIDPTFNEERIRARDEAYARAIAGADEEHRQTLARKEVIQKRKEEVSELLARKEKEDATRKRIRAAQLQEAEDKRLALEQKEREERRLQAEMDRVRKEELKKQIADLKIGPKTLDIDLDNLDNVDSNTIRAMKLAQLEREKNDINEKLRVTGKRIDYLERAFRKEEAKKLPLDYEAQMRKDLAIYEKIKAQTLRDAEIKHKESLELKHRLSRLIPRYETYRQSIVERRHDEFEKRRRDAERELEKAISLRRREFRDRKARERREKLDQERKLREEEERVAKEAEEKAAREEKRKVELAEVKAIRERERQEAMEIAALQQRRAEEAEQRRALAKATGTSLSKEPELSQTSRWQSRREQNISTSQRTSSSTLRGPYSAARPDDTDKSGPPPLPLVGSRTGTGGWRDRVASRTAQRDPSPRRENSSQLASVEKALKPSGAVGKFIPPHLRKKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F6</accession>
    <name>A0A0B1P6F6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001720">
        <property type="protein sequence ID" value="KHJ32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F6"/>
    <dbReference type="HOGENOM" id="CLU_350624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="803" mass="91008" checksum="D13244A126AABE63" modified="2015-03-04" version="1">MIRRTLSSRSEQVSNDFPSPEHLPVRSLDRNLDIVAHGTVASRVHQLQGLSSKFSPESRSNERNDNRESSYTKFGRRITKRFSQPAQRNSKPSEETQYETTHSYNGINTSYISDDQNLGIINARTKPDLCDKKAQVGTLVPTVKIKYDKPSSWKDTFKVASRSLGVACASPDVNSSQEKANSINNQVISEIYAPTLLSDFPNDHLKSLKHKEELKIQKRGSDSSISTTSSMRRRSVRELFAHHGIKTPPGLASSVKTSNTVDSNNLETHYYCHRCSFINKKNAAVCYNCENLLKSHNDLRENQNSIARPNRELESNDPDIHKKQFLELDSTSFIRKSQRSRPSPFQPNEMLPNKDLKSDKSKTLSREFSQRVNTYKSTRENSREKKDWETANPVPFLSGRNVTTSVKQSPFFARDSLEVSSLGQSRPRVASKKFSCDTLQLDSTASQNREYGHMPLRHCISLSKTQQNQYQVDSKNERQMGDIFLEKGIKLNPQYKALTINPTNLKTAVNIQSKKSLDTQNKKTAEKICVEIDDESHPLDAKIFLKNVEKNDPTATHKKYSKGDFQPDTKDFPFADGYTEKFGVPPRENSVLFRSAARLNKAGSISKSNTEILNLSGRQHAFPSRDIDLEATNKPELGNFLRREKAIDFPSKPDSKLSKVNSLLSPQEEASVTSEIDAKSDNERKKLRRIKIAKKIKLNLPQITDQTVNNLERKIRENLSEDNSHLTGMAISSEPSKKINTDRWMELPPINPGDYRSHWERNADTSLTDITTQEIRGVTVTLQLEGRDDMVFKAKPSKTGVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K4</accession>
    <name>A0A0B1P6K4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001162">
        <property type="protein sequence ID" value="KHJ33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K4"/>
    <dbReference type="HOGENOM" id="CLU_055657_0_0_1"/>
    <dbReference type="OMA" id="CTDILPR"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="304" mass="35173" checksum="5D73EECAF4BBAD5C" modified="2015-03-04" version="1">MMRLILSTNNITCQNLSSLQKPNSELSESELSKALRYKFQDTQDKFRYLNLLNIFRTGDLQTLSHVPGLTLEHLSGYYIPRADISTSPLAEQRSQYEITVKIFYLSEKDLRSKEYANDAIRFVLQKLDVEYIDLLIASFPNRLSNGETGKENEDFSEEDIEENVATWTELTLLQEKGIVKRLGVADFNNNKLGKFLKRVKVRPQVNQMNLKNYCKITPSMQELARLEKIELLTHRDSRNMLQNFSLSEILKQDNEDTNLSSHNDQSLDNVNNILSSKWVAKYTAVVRDRGVIEYKGYFVAIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6U4</accession>
    <name>A0A0B1P6U4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000888">
        <property type="protein sequence ID" value="KHJ34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6U4"/>
    <dbReference type="HOGENOM" id="CLU_029955_0_0_1"/>
    <dbReference type="OMA" id="MYISADM"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="40750" checksum="5DA1F8A8197CCC9A" modified="2015-03-04" version="1">MKVNPILKKWTQNDPHSFDLDNPNDVRNILYEYRFGTESQKTNELEETSENGKALHNRSASKASQYSVATAGSGQRAGFFVHPFQQTPRPFTPTYTAPTTSSIDLTLNNDFSSRWIEEEVDPQNNHYYFSTSNSSSYHSQPPPLSSPSSHIPHAHFPNKSSFSRLALVSSYPSHSSQSNSNNDFSSSRTTTPSLSSSISIEKGFRLRSRSEVINRGRAKSIQEARRRFIEKERVQEEKAAREEIRQLEKRQQKEAIRIERSNRQSSASLSCRSKRSKSDATSHETSESLSTISTDMYISADMKLKDSLISEDIPPGQKRGSCPAKQKTYSAWAMFLMWFRMRLMHLRSKICYKSSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Y0</accession>
    <name>A0A0B1P6Y0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002100">
        <property type="protein sequence ID" value="KHJ32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Y0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Y0"/>
    <dbReference type="HOGENOM" id="CLU_053381_1_0_1"/>
    <dbReference type="OMA" id="MPTYTIM"/>
    <dbReference type="OrthoDB" id="5421909at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058946" evidence="2">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="273" mass="28241" checksum="83A263D003FC6CF5" modified="2015-03-04" version="1">MHFSAILLSSLGFGYVFAQAKGNQKNVTSAASTSTPSAPSTSGSASPKGQVKVHVVRVGANAATKFEPNRLSAQVGEMVQFQFAGGNHTIAQSTFDQPCVPISMVNPKVTGFYSGYMPVSAANDMMPTYTIMISDLTPIWIYCAQGQHCEKGMLMVVNENVQANASRTLENFSALAAKAVTVQMKGDAGPGTGTNAGTPVSPDGNIPKPSGASSKPSGTPSKNSGKDSKSNSSSNVPEEDPDISSSPISSSGKTSVNIVLFALIGFSTFAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P739</accession>
    <name>A0A0B1P739_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001854">
        <property type="protein sequence ID" value="KHJ32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P739"/>
    <dbReference type="HOGENOM" id="CLU_151460_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="84" mass="9365" checksum="EDEE43B4D12EBF40" modified="2015-03-04" version="1">MPAKSKSSPSRGAGVNAQHALHVWDSQKDSHNPSLQDSHSSPRVSIVFVSTSLSSQHLFSRSSHDWPREYRVKGSILSQRTNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P760</accession>
    <name>A0A0B1P760_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000827">
        <property type="protein sequence ID" value="KHJ34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P760"/>
    <dbReference type="STRING" id="52586.A0A0B1P760"/>
    <dbReference type="HOGENOM" id="CLU_004893_2_0_1"/>
    <dbReference type="OMA" id="PHWVRTE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="147"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="366"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="635" mass="71831" checksum="D27EC846D35E87BB" modified="2015-03-04" version="1">MVLNLATVVGAVTPVIVSTFFSHIKSKKSRVEKPISSLTYEEGLVVVRKFLEFAAENTVEDLQRFSSQWIPRPYSVKVEKAHIPDEFLDSSAKCLQTQLGPDGLEEIGGKTWWHWRKPGSKLSADWIERRDHYRQRITGQSHGDRVLFYVHGGAYFFCSVGIHRFQMQKYAHLLKARVFAPSYRLAPQFPFPCGLHDCLAAYMYLITIQDPTTIVLAGDSAGGGMILSILVMLRDQNLPLPAGAILISPWVDLTHSFPSVLDENPLDYIPKGGFFHKPSESWPPPASEDAPSDQKIIHNLKTKQSSTSLSIIEGSPSHGFYLKNTSVDKLSNSLKESKEHVNKTQRAKVDLTVEINGERVKLIDQIQLYAPNLLLSNPLVSPIFQPSLAGLPPLFILTGGGEPLRDEQIYLAHKAANPSKYPPGDHLLNEGDKEKIDRWKPTYVQLQVWDDMCHVAPILSFAKPVQHVYSSIAQFGKWAFERAQKVQIKHISGEYKNLSINAMLNSEEFPEESSQLEFFSADNIQGSVFEGKVGENFPLFKNYMIRQKVNIHGYFTSLKPEFELEACKMNPSDIGIVKAGPVLKWMETKQNWDKKFGDLRRRVEEKQENILKHGKKVYAEEENPPLTALVRRIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P785</accession>
    <name>A0A0B1P785_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 2-epi-5-epi-valiolone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001042">
        <property type="protein sequence ID" value="KHJ34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P785"/>
    <dbReference type="STRING" id="52586.A0A0B1P785"/>
    <dbReference type="HOGENOM" id="CLU_001201_0_4_1"/>
    <dbReference type="OMA" id="TCAHKPT"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="195"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="451" mass="50429" checksum="02153EDECC650303" modified="2015-03-04" version="1">MSDMSATVTKTEDGFSVAGYEKLKYDFAFVEGIFDLENKQLANCYLKWGRVLTVLDKNMKALYGDDIQKYFDHYKIPLTFHAMEVGEKAKNLESLLGIVQSMTSFGIIRKEPVLVVGGGLVTDVAGFACACYRRTTNFIRIPTTLIGLIDASVSIKVAVNYGNYKNRLGAYHAPIWTFLDFNFLKTLPISQVRNGFAELIKISSCADLKSFNSLDKYCEELIATKFGRMPGSDPEIRRIADEINYDSIYEMLRLETPNLHELMLDRIIAYGHTWSPYHELLSDPPLRHGHAISIDMCYTATLGLDRGLLSEEEHTRLLTLFSRAGLSIDHPLYDDHAIEKGTEAILKTRDGSLRLAVPSPIGKCQFVNEYTMDDLKRVLKKHKAIALKYPRQGDGIEVYVDASDTGELPALSTSEVKSKVQTRTLKGILNGINNDNKTDSKPSIKSVVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7D7</accession>
    <name>A0A0B1P7D7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory factor sgt1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001802">
        <property type="protein sequence ID" value="KHJ32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7D7"/>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="OMA" id="TKDYIWQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="62308" checksum="82CFD5AED8F5BF71" modified="2015-03-04" version="1">MNRRRNKSTMDSSDQHKPASLEDRFRELRNTREDYVEYSLYVIDSMLKTQDEVRNVCEVILRKSLEITKQLLEDHIWSCDSFKLEIQEDNDKIYLHGVTNFGDSLEDEWLIVYILKELSVQFPQLWIQVVDVDGEFLLIEAANALPRWLNPEIADNRVWIHNNKLYLIPLHATGCLSEPLKKSPISRSLKLSESLQIIEKNPVALICPPLVEKEAFYRLRNYPSQISESLHYALIQIPRRLAYILQRLPALTSPSVEAFYLRDPISLKYIKNDPSKFLFPPEDLVKMTTKFTKLRFAQLKSQEFQAPLSWEKKLQDAKKNDENSYEQLKLGMKLTCGVEILMKDSLYKNNKFIEKINLLMKENALDKTSALPSDVELLCWNEKFREDNENWMKIDFRDFERELDGKSGGKNLGSGFGDAKTQADLKKMVERFESFLNDEKAGPDGIELDDMDIDDDQKSFEDKSSDDSSDEDQNKDLSFDSNEFSRIIKEIIENPLNSIESDSQSAINDAKEMKETIEQMEKELRESGALNFDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7P9</accession>
    <name>A0A0B1P7P9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001487">
        <property type="protein sequence ID" value="KHJ33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7P9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7P9"/>
    <dbReference type="HOGENOM" id="CLU_021711_3_0_1"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000144">
        <property type="term" value="P:positive regulation of DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="457" mass="50249" checksum="E81D32D9ACF1FCAF" modified="2015-03-04" version="1">MAESKLVWNPDNIRDVAESVGISMLNEEAVRILTQEVEYRVGQVIVEAMRFMRQGKRTTLGTQDIAQALRVLDIEPLYGYESTRPLRFGEASLGPGQPLFYIEDEEVDFEKLINAPLPKVPRDITFTAHWLAVEGVQPSIPQNPSTAEARATELLPKGPGTNPSLAALAGNENVSFKPLVKHIVSKELILFFNKVKSAILDENSEQEVLMLRKAAFESVRSDPGLHQLVPYFVQFVSEKVTHSLNNIFVLQQMMELVQAMIESKSLFIDPYATSLAPPVLTCLVGRNVGGSTMDGTKSQFQLRDMAASLIGQIAKKFSKSSTELRARLARTCVKVFLDPVRTPGELYGAINGIASVGGPSAIATLVLPNLKAWEYILVKAQNERGSDENSIKMLIAAVIKAVTTLSDDSSPFTHSVSDKNTDEVEVKDYLGSIIGSRIVALEDPKLIKAILKLKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P872</accession>
    <name>A0A0B1P872_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative centromere binding protein b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000859">
        <property type="protein sequence ID" value="KHJ34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P872"/>
    <dbReference type="STRING" id="52586.A0A0B1P872"/>
    <dbReference type="HOGENOM" id="CLU_1054464_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="274" mass="32319" checksum="0B6CA6092D6DF656" modified="2015-03-04" version="1">MTAVRRSIERRERRALRAWYFQQDPRPSHKECIAWFEGEFHHKLCQSTISESLSDRYSYLDNPLPSFSDTHRRSRPSQWPILERILFEWQQSLQQQGNLPTGDLLIAKANEIWPKIPQYRDRPQPKFSAGWLSKFKARHQIKKKQRRHTEPVCISTLADYNESKNLQPMPSESQGNINMSSTSIEEVPIEDEDTKNIPHEAQTIEYSSNIVKERQPKIPSRGEALSALQTVLLYMQNQQTTQHWELQLLLKVEQELQQAMQDDINQTTLDRWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D4</accession>
    <name>A0A0B1P8D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd-repeat protein pop3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D4"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="326" mass="36444" checksum="8A27775FCC15DB4D" modified="2015-03-04" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLSISPDKKYLAAAGHRSIKLYDIKSTNPNPLLSFEGHNGNVTGIAFHCEGKWMVTSSEDGYVKIWETRSGTLQRSYNHSCPVNDVVIHPNQGEIISCDREGSVRIWDLAENNCSHQLIPEEDIPVASVTIATDGSTLCAGTNSGNVYVWYLVISEEKTSLIPITHFSAHSNYITRVLLSPDVKHLATCSADHTTKIWEVKEVGQTSPSLGRSKFDEKTPRAFVLESTLTGHQRWVWDCAFSADSAYLVTACSDHYARLWDIQTEEIVRQYNGHHRGLVCVALNDYSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L5</accession>
    <name>A0A0B1P8L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000558">
        <property type="protein sequence ID" value="KHJ35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L5"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_1_1"/>
    <dbReference type="OMA" id="CKQHITL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="260"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="527"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="816" mass="90499" checksum="CFC125B8834B8EE0" modified="2015-03-04" version="1">MTSKRKVAAIAPAVDETIDPADILTFLCLGGGNEVGRSCHILQYKGKTVMLDAGQHAGYEGLASLPFYDDFDLSTVEVLLISHFHVDHAASLPYVLSKTNFKGRVFMTHPTKAIYKWLIQDSVRVGGVSSTSQPVYTEADHLSTFPLIEAIDYYTTHTVSSIRITPYPAGHVLGAAMFLIEIAGLKIFFTGDYSREDDRHLISAAVPKGVKIDVLITESTYGIASHIPRLERELALMKSITTILNRGGRVLMPVFALGRAQELLLILDEYWGRHPELQKIPIYYASNLARKCMLVYQTYVGAMNDNIKRLFRERMAEAEASTDSKVKGGPWDFKYIRSLKNLDRFDDVGSCVMLASPGMLQNGVSRELLERWAPSDKNGVIITGYSVEGTMAKHIMQEPDQIHAIMNRSGGGGGGRRGLGGVNEKVMIPRRCSIQELSFAAHVDGVENREFIEEIAAPVVILVHGEQHNMMRLKSKLLSLNAEKTTKVKVYSPRNCEILQIPFKADKTAKVVGKLASIPLPGTDGYQSQLVTGVLVQNDFKMSLMAPEDLREYAGLTTTTITCKQRMTLSAAGIELIKWALEGTFGNIEELGEEKLIKTNNEDDSMNNSKKQIEKDIKVTSYLVMGCVTVRHHNNGELELEWEGNVLNDGIADAIMAVLFSVECSPAAIKQSSQKHSHSHSHKLPARHIHANLSPTERLERLFMFLEAQFGIDNIAPITVPKLNSSIIAPSKNIKPEDDTDEASHAESEQRNAERVEIERLHKIGIPVPGVEIRVDKNVAKVWLEDLEVECTSRVLLERVRGVVERAVEVTAPLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8M8</accession>
    <name>A0A0B1P8M8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cue domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000555">
        <property type="protein sequence ID" value="KHJ35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8M8"/>
    <dbReference type="HOGENOM" id="CLU_026590_0_0_1"/>
    <dbReference type="OMA" id="KMSLVTQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="677" mass="76612" checksum="6DBFA3AAA587C4EF" modified="2015-03-04" version="1">MSQQLPPMAPYPEEDWVAHIAPAEWEACLDSWIAIGGAHLALSDSAFHDISLNDESLSAFLTTFVANQFKKTSKSESHDGHRFLIRDPSKLKPVRKICFLLSCRLLETKTSTTPLVLLTWEFLADSYKIFGRNHTRKLYSLANTNHSSTLESSVMSLKNSLIKELDAGINGDLVKTELQLKKLNHLLYICPEVAQFFMAGSDYLDALISCYKIMNPPLRKTIILNVYLCLIGLTKDQDPNFSLLVDQLYSLKAAAEAHLDSIYNADDSLVPELITITPILKKLEKRMSIDGNGSGRAKYILSALQSFRKRGKSMKSQNPVKRKLEKGKKKVVATHEYRFDVDEQSQVQRLSLISQVQELFPDLGSGFISRILNEYDDNLEVVISHILEGSLPHYLNEIERSEKLKSPPEIASTQGLKADKTYPTLPIRHNVFDDDQFDRGEIDPSRVHFGYRDSSQTAENLLDNRSLDLKKEAIFSALAAFDLNDDERDDTYDFADVGGTVDTTHPEDELEAQTNNSSQIVYNEILFRAYKMNPQLFKRDSAVRRGRDREKLRKQVGLTDEVIEGWALMLIRDPKLLRRLEAKFDGPGNSQRKVVLPSWKDHDSREIDDRLPSGLENKKQVNLAHSGVKKYGAENNENRDFRTGRGGKGSNEGSRANHNRKRQRAKKVAKAFSGPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8W6</accession>
    <name>A0A0B1P8W6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8W6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8W6"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="46389" checksum="6542A9E80ED2099B" modified="2015-03-04" version="1">MRQRLFPSLKKNLPNPRFSSLSHTRNNFRCINTSSNDTVESAPSDIDVSKLSLKLTPHPKTLIPNNELIFGHSFTDHMLSIKWTAKNGWSYPSITPYQNLSLDPASCVFHYAFECFEGMKAYKDRAGNLRLFRPFQNMARMKKSAARIALPTFDESSVVDLISKLVLIDQRFVSGEKGYSLYIRPTIIGTQSTLGVGAPSSALLFVIASPVGPYYPTGFKAISLEATDYAVRAWPGGVGDKKLGANYAPCILPQLEAAKRGFQQNLWLFGSEEYITEVGTMNMFVVIRDKDTGKKELITAPLDGTILEGVTRDSILSLARERLLPEEWTISERNLSMHELFESSKEGRLLEAFGSGTAAVVSPVRNISWKGRIIDCGLKSHQEAGHVASKMLQWIQARQYGEEDHEWSYIIPQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P949</accession>
    <name>A0A0B1P949_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative nuclear pore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001581">
        <property type="protein sequence ID" value="KHJ33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P949"/>
    <dbReference type="STRING" id="52586.A0A0B1P949"/>
    <dbReference type="HOGENOM" id="CLU_032441_5_0_1"/>
    <dbReference type="OMA" id="WFRLWAE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="45964" checksum="78D9AFB885F5926B" modified="2015-03-04" version="1">MEDQASGELSDFCLLQHGHRDMVSATTFNSYGNRFGTGSVDGTIKVHNKNKDGSWHLCDSWSAHSSEIHQIQWLPATIYPNLIASLAADGKFRIWAEDPAIPSGKGRRFNSSINKHIFELCSKSRSTFISFTITHNHFSRHSFLALIDRSGSVVAYENNDPENLESWVEIDSFVACEKPARGEEISFKIAFDPNLSPTYTAIMQGVPKDALGLVVAAMYTASVWRTREITHSVSLGSETRKEFYRAIELSGHKGLVRDIAWSPGNVRGHDVIATVCKDGYLRVFKVWTPSYKTKKNTVASIKSEDIQLSKSVLTSSRVAAAGPKNIPSSFSSETSGKYPASGGKEKDCTVVHLAEEITRLTVDESCLPPWKVEFDADGLLIGTTSDDGKVSLWKRDVNGIWAKFSELVMERNECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P952</accession>
    <name>A0A0B1P952_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000477">
        <property type="protein sequence ID" value="KHJ35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P952"/>
    <dbReference type="HOGENOM" id="CLU_897706_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34040" checksum="6FC1B89E8D668137" modified="2015-03-04" version="1">MGRPTNFTQRFQQFICGGANWSRSLHAHNATKKKSIFSCKDQTILQSDGTHTKYSSSSVQGGATCLATTTGTAPNIIKEYEIHPTAVDLDDNEIFIEQLENLILDPMPDTLETQNESDNTSASIFFTSIGPINGNIIVQHLANKPFTHALTTHKNIIDNPSISSTFLHERYNSEEFFGIMIDTGAAAQPTAGYGQFLAYQKLSAVTLNTNTAGEVTVKFRIGSAISIGSVNIKMPIGTVKFYVLHTDIPFLLSITDLDSPKVYFNNITNHLIIHPISDTQLFDVLVTLSCFGKSPHNQSSKSHSRLLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C6</accession>
    <name>A0A0B1P9C6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001131">
        <property type="protein sequence ID" value="KHJ33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9C6"/>
    <dbReference type="HOGENOM" id="CLU_539905_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57194" checksum="6E6692F66885B18E" modified="2015-03-04" version="1">MDVLSFQQLIVLVSFTNWKVKNEHQHRLTVATHRGQENFCRAVMGFRNSPAYVQRKIDTILRAERTFARSYIDDIVIFSRTFEEHLEHLKAVFQKLKSFKIVLSAKKCFLGYPSVGLLGQRVDALGLASAKGIQNVNLTNQLAYPVSIVQVGEEWINKLKVSYKADQRCSKLIELLESNGAQGENAAVLPFKYTRGILYAKEDETHPRVRSVIPKNMEGEVFSNAHDQLGHLGYDRTQERLSSNFYIFDIGKKLLNFNPIDVVSSRGEVRKALSTREQYIAQRARGAYIASVCQPEAAFDLAFAAQNVNPDSTHIKMLNKRIEWQMNNPTRGLKYVTLDKESTQLLVFTDSFFANNIDTSSQIGFIIVLVDKNKKANLIHWSSIKCKRITRSVLAAELYGIVHGFDIGVAIKLTLDMILSTTVPLILCTDSKSLYECLVKLGTTQEKRLTVDLMSLRKSYERRLITEIRWIKGSTNPADAMTKSSPCKALQNIIDTNTVEIETNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U8</accession>
    <name>A0A0B1P9U8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g3008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000380">
        <property type="protein sequence ID" value="KHJ35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9U8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9U8"/>
    <dbReference type="HOGENOM" id="CLU_018539_3_1_1"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="63877" checksum="D87067C6DDAD88CB" modified="2015-03-04" version="1">MSLYDFRDMLNISGEARRSGKRQKLNGPKAALKGLAREVQNLNGDNPIAIVPKTSVFKKKRLGSRKPATKWQLKPFKNTARDDQTLILKHWRRKSEEPVLSDGENLEIGSKSDIEDSIFARFNVKIKVVSYNENQYISHLQNPDWTKDETDYLMNLVEEYDLRWPVIWDRYDYLLPSSETKCGTNEEVTLPTKNTRSMEDIKERYYKVSAKIMQLSHDNICMSPHESNQLEAMLKFNKQQEISRKRYAEATFHRTIEEAKEEENLLLELKRILARSEKLGFERQELYDLLDAPPSTNPIGAYTSSQGLQQLLASLVQADKAKRSKTLSRATVSPAVPNQNSQANVFVDSRRDSSVRESNFATVSNKKVTSGLPDRRQLTPEEEILYGVRYFDRINTTGPAFRHDKIMKIMISKSSIQQAKIRNILTELRIPPRLLMPTYRVGEIFECLQQDISALLELRKIADKLQGEISMLKALKDERKKLTQSPELNEQHQKDISKDNGDDENFIREATTGEDNEPKIELIEDENKEVSTTLSVHKRSNSVLSNQSLKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9V4</accession>
    <name>A0A0B1P9V4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative isochorismatase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001432">
        <property type="protein sequence ID" value="KHJ33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9V4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9V4"/>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17743" checksum="1D0C4C7F0FE07B7C" modified="2015-03-04" version="1">MLQAASILSIPVYATTQNRNRLGETCSELNLKNAIENVDKMAFSMWTPAVARHFRRETPAEIAIVGIESHICITLTTLDLLANGHKVYILADGVSSRNREEIPLALKRLQAEGAVVTTSESFLYECMGDASIPEFKNIVNLVKEYNEDTKKALDLFSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAA0</accession>
    <name>A0A0B1PAA0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000318">
        <property type="protein sequence ID" value="KHJ35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAA0"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13310" checksum="B1C76663231D8B4C" modified="2015-03-04" version="1">MICTTAYSSIESALTNFHDEIEKEEVVAFKAYLRQAIANFAAVDNSPNPPKIPAHSKPTKGNDSGSGKGKNVEKNVAVATPQIPKPPQTSQNTWVTVARNGQKKAHKTTRDKFRESLSSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAF4</accession>
    <name>A0A0B1PAF4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000477">
        <property type="protein sequence ID" value="KHJ35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAF4"/>
    <dbReference type="HOGENOM" id="CLU_1054465_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="264" mass="30185" checksum="B7E09E41E3489589" modified="2015-03-04" version="1">MADQTNVGHKSKGKRSESPLLHHESLKENWLDGIDISSSPIELVDYISLKYDEYMFTEIRLPTLQGFRKLLRQHGIYVRKTKVSCSIAIAEALNSQYREWTKSEVEEIIKDKTFSYVSGKLQYIKEQIQTQNTFSSTLPTPSMIPTPMNIDTPSPKQFDRSINPNQTIPNVAPHESKHLNFNPNPSNPQIHIQPSNNLPSNTQPHNNYPSNNQQLGILSKLYNEDMKYSGEEANFDFKLTIFFNTCQRAGLPENSILLAFPIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAR9</accession>
    <name>A0A0B1PAR9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60s ribosomal protein l18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000434">
        <property type="protein sequence ID" value="KHJ35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAR9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAR9"/>
    <dbReference type="HOGENOM" id="CLU_080024_0_1_1"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20683" checksum="2EE87C5A203708DC" modified="2015-03-04" version="1">MGIDLNAHHVRSTHRKAPKSENVYIKLLVKLYRFLARRTDSAFNKVVLRRLFMSRINRPPVSISRIVANISEESKNKMVVIIGTVTDDARLLQVPKLSVAALRFTSTARARILAAGGETLTLDQLALRSPTGSNTLLIRGPKNSREAVKHFGFGPHKNKKPYVASKGRKFEKARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW6</accession>
    <name>A0A0B1PAW6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000840">
        <property type="protein sequence ID" value="KHJ34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAW6"/>
    <dbReference type="HOGENOM" id="CLU_072604_1_0_1"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="71"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="25910" checksum="933625A9EE422AE8" modified="2015-03-04" version="1">MSAPFEERVSVPIDDPNADTEWNDILRKHGIIPQKPPSPTLLVEEAILESRRLAHENRLEGKDLDELDELEDLEDEEFLATYRQQRMREIQKLYKKSIHGTVYPITKPDYSREVTDASTSFTVLVLLTSTNVESRKLSELWKQIACKYPEMKFCEMRAEMAIEGYPERNCPTILIYKEREILRQVVSLKTLGGLNVQVMDIENLLLDVGVIVEDSLRTKSNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAX9</accession>
    <name>A0A0B1PAX9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000240">
        <property type="protein sequence ID" value="KHJ35827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAX9"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="226" mass="24549" checksum="D48CAC8044A8C01E" modified="2015-03-04" version="1">MSDSMEISQETQAPSTETSNQPPPIPPIPPIPNSPSPFATPTTPSDSQLPNNNIVGRPILKPTAPSKRPASVKIPQISRDNIGVENLFLPKELAEIIATRQRRERAWHARVLICTTVISYIDNTLAAFEDEIEKEEAAAFKAYLELAIANFAAADSSPTPPKIPSHTRPIKISGQSIGKDRNVAKKVDIAIPRDVLSGASNVKNVQEALKLPKIPQISDTTWATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY2</accession>
    <name>A0A0B1PAY2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative gpi-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY2"/>
    <dbReference type="HOGENOM" id="CLU_044656_2_2_1"/>
    <dbReference type="OMA" id="VMESQFP"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="395" mass="45714" checksum="F9F413C0116647AD" modified="2015-03-04" version="1">MRIFKWVELYFIYITIFAAPAFISAEHTSNWAVLISTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNSDRAVDLYGDNIEVDYRGYEVTVENFIRLLTDRVDEEMPRSKRLLTDDRSNILVYMTGHGGNEFLKFQDAEEISAFDLADAFEQMWEKKRYHELLFMIDTCQANTMYSKIYSPNIIATGSSEIEESSYSHHADNDIGVAVIDRYTYYNLEFLENYVKDPSSKQTLGDLFDSYDESKIHSRPGFRWDLFAGGERSGRERLVMDFFGNVQNVEIYGADNTSGWDQDLLEIGIKMAEIEKSNEAQSLVSKNESTDFISANQIVSIKNAKERIVYRVERDRKVWGKKFVGIWVLMGLTVAWLAALHLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB2</accession>
    <name>A0A0B1PBB2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000782">
        <property type="protein sequence ID" value="KHJ34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB2"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="CCGGCVI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="214" mass="23954" checksum="0028724EDABC1D01" modified="2015-03-04" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDEEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFDEILVFQQQILRVKDKDYFPIIVVGNKCDLENDRQVSEAEGEALSRSFGCKFIETSAKSRINVDNAFYDLVREIRRYNKEMTGYPGGGGSGPGSGVPSGKLEMEGGEQKRNCCTNCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBH8</accession>
    <name>A0A0B1PBH8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000159">
        <property type="protein sequence ID" value="KHJ36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBH8"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="OMA" id="PPTHKTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="23727" checksum="351C8BA701EF79A3" modified="2015-03-04" version="1">MPAIRTKRQFSTVDIAKSRARARLKNKGLAPDLKDIDAVEASILDTESPDIEMIDAEIDRLIAKGLKESCWATPQAQAASSTKATTVDSTQLIVIKDMLTPIPEAESRAQKDKGIAAQRPITIDLTASQISSLSHNKSISITEPQASLNINETGKEKSYPPELQAIVEAEKHRAAQTAANSEVCTAAINGLETALLHLRVKTQIQFVDTLKTYLRAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBJ8</accession>
    <name>A0A0B1PBJ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001085">
        <property type="protein sequence ID" value="KHJ34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBJ8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBJ8"/>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="33351" checksum="6EB95503CB54FB4F" modified="2015-03-04" version="1">MPINQPANQIKLTNVSLVRLKKAKKRFEVACYKNKVLEWRSGIEKDLDNVLQINSVFLNVSKGQTAPSVDLAKAFGPNTSVNEIILEILSKGELQVGDKERQAQLERVHNEVISIVASKLVDPKTKRVYTPSMIEKALDTLCSKGSQSQHDKNTTPITGEDKILRSKVKEHVWTGVVATRSAKSQALDAMKALITHQPIPVARARMKIRVTCPISIIKLPVKSNSAKVSENEENFKGTVKDRILNFIETLEAQDIFESEWTATGFVEPGTFKILVDFIRVETKSQGRVEVLDMAVNCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBL2</accession>
    <name>A0A0B1PBL2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-oxo-5-alpha-steroid 4-dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001081">
        <property type="protein sequence ID" value="KHJ34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBL2"/>
    <dbReference type="HOGENOM" id="CLU_043418_1_1_1"/>
    <dbReference type="OMA" id="FQMLWVW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="36381" checksum="41EE0C71B41B6A5C" modified="2015-03-04" version="1">MKRVLLLDDYYLTITLLITIFYQLFFFSIAFSFKFDKLTDFAGGTNFALLAILTLFLSGNPNARQVVTSLFLIIWALRLSGFLLFRILKTGKDDRFDDKRDKFFPFLGFWIFQMLWVWIVSLPVTILNSPAVTKYPQSKFGNSQDVIGVLLFLLGFSLESISDIIKYRFRSSTSDKSLFCNKGIFAWSRHPNYFGEILLQFSIFMIAVSPAASGDIKGQAYKALYATIVGPIFLTTLLMFVSGMNLAERPTAKRRYDKRQNWEEYARYLNRTSILIPFPPVLYSRLPLFLKRILFLEFPLYVFDPAKHSNEVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBP8</accession>
    <name>A0A0B1PBP8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000302">
        <property type="protein sequence ID" value="KHJ35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBP8"/>
    <dbReference type="HOGENOM" id="CLU_228178_0_0_1"/>
    <dbReference type="OMA" id="FSAIQCE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2503"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2507"/>
            <end position="2521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2534" mass="289274" checksum="8EC817C6107E2648" modified="2015-03-04" version="1">MEESPSERSTSSAPCSGRPSSYDDVTEHPLRKKQRTSHAVPRSRSVDEISKSNSSLNDTTLLIDPPELVQKVLTPTHDSSQVFVDQSPSKVTINIRTNHSLNTISSSPPISDTMKHLQPSHDSQDTQIIIESESDEFSTATPSSSPILVSSPHVELLPLEDTDLPDQDPPIALIDENEDENGDANDINDNSEIFSKFPYRVDGEALSNTLNRLFRFFQCDEVVSDEVFCKIHDWIDMYLLITTNTDIFYENFVKNQEFWASLPEIVWALSHRQKYLGDFLRRSREGRQALTNMFCQFGRLTSRFLIVDLKILSSYPSELVDEPILGSQPYLHALGHLLHKDETPHIGKTLEVHYHWNFDDDISQICYDFKVNGGTISALKKYMECQLRLQPLTPYTVEKIVYPCRIVEILISESISLNQESRLLEDNEMNVDTVETSFLMSYDLFLTISSALENIINKHITSLSPDAVTTLLHSLAYILKSALSINSQFTQRIFKEKEKKFGMISTQDYPVAISVEWKFKILKKLINCAQMQLRVIGVTTMCTELLQLHYSNRALDIGSSPILLYFANYILENKLVDYVVGTGSHPEIINESSNIIGFLMVTKTYKPQQTDIIWHTVKTCQDQRVVDAILRMLSHCHNLFDGDNLLYLCTKAIDIRLESFTPAMRDLFQALFKNLMTKASAEAVVPAPPYHLCVRLIRESSKLTEDNIVNYSEIQIWAASRFREILSYGPSSWDRLDIYQQCMKDILLKSKTAPGSLCVINTLLSSDDYSELIHLTTDYDLTRLLIDELEDLASADNISYIQLLRTTPAGHACRNLLLRIIKAVPGTITPDLGERLWNTLVGTKSQKSPETNSWWQTLNAAAKQSQRNNIFLTRCFQDYLPKLPPHCFTPGALEFAREAVLNWLEDAHYDLIEDKKPFKSLAIEQIWHMVLTASSNTIEESAINILVEIYVHSALITSITRPKAHIIHLDLINRCLNQLKGAALELKNLRSGTHRISDGKIDSSTLEDQFQAQEKICIRSLAVLREFLRVYYLKPQFSNIHAKSLTLQDASDEVDGDPVTFKYQSFDGNNHTEVESIVLGHKNNLASLLSTLQKVTGFKSFKIYCGGREFIPSDKDMKKSVTELNLKGLLLVKYYQDIDTDIEASSTIGKTAIEQEIIKHFDDLWSYLGMHEEVAREIYNFLKNFPIYDHLIKCFNSDTNHSEIFPTGQPFKSLYAIHGLRELINPRSPSAMLADEAMLFRAVSLIVATISDPTFFDSCANNELKNLLLIQLINCLILFLKKPLPPSSISSLLDKNLLEHMLKILMETRLSNESQSHHVTSILFESIIESSIHSLKFWEAFLSHLKNSMLLRELLLESPHYSIRKGAAKVILEKCTQFTNSLVQVSSITLVSELWPLVLLIIPDVLRYPQNCEQLLSVSYSLFKKVVETSAETLKIEDLVRQWGILLVSHTSLESPDQPENIDMVAQGLGIILHYATSVAKSAKQSLFCGNLGTKIFRKHLFPALSDVKDDLISPNIPILNSKTRGIISETVFYLIKDDDAEYWEVLLSIDSLIPYNASPDHSPYSFDLSFLFEKNKSVRSQTGYVGLRNPSNTCYLNSLLTQLFMNISFRSFMLSALVFDGGASQKLLSETQSLFSHMQHSYKRFVDPEKLASSIQTYEETQIDVTVQMDVDEFYNLLFDRWESQMLAPDAKNKFRSFYGGQLVQQVKSRECPHVSEMLEPFSAIQCDIKGKSCLEESLQAYVDGEVMEGENKYKCSTCDRHVDAVKRACLKEIPDNLIFHLKRFDFNLRTLQRNKINDRFSFPNKIDMNPYKVEYLMNNTEVISEDIFILVGILVHSGTAESGHYYSYIRERPSNQNKEKWFEFNDECVSSWDPASIEGSCFGGPDYQGQTDNSVIYDKSWSAYMLFYQRYSSTNSQNFHCAQQTPARIPIPKQIFNHIAVENELLLRKYCLYDSSHTLFMMKMLQNLKKFNSNECDAISQHLKKIALRVAFNHLDQVVSRTKDLPDFSTYMLQLIQSFRACAENSRLYLEWLCECREALCQLLIKNPEQLIRKEIASSIILTLCKVKSDTPSVYGFLDSEDSDDEQEDGHSEIFEKVIGALTNLWDIIHTGFRAWPEYFGLLTNIARIGPPEAATILSKGYLNKTLDIITADPNLPLTVQYTKMLNIISKRNATRPISYEAVISLLWQMMQLCDASLEPVYESEERLELVLNDRPIPYTVSERNLLVQYWTRSNSNILTEKLLQINQNEKATEAILIDLLNWDETIDVQIRNTIISGIKQSISSCTCRPFLRAAITYCEHSKDSKGQQIMIVHVSKAASAIEHLEGKDFIKFFKDIMSVKGNSDLSDEELHQFIINQIPTWAPCMLTNYDHDVRQLTEEYIQEFVLNYLLEDEENSDSNISDSKHLNFLRGVSQKLAMRCLEFLLENYIRPRQTTAQGILTNIQAVIEACEETFGEGTPVSRRYVEQRNCKFRARLISNSNQEIAAVRALKKLIVDEAEKETSEEWENSDGDYDESPEFIDGATEIENGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU8</accession>
    <name>A0A0B1PBU8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative endosomal cargo receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU8"/>
    <dbReference type="HOGENOM" id="CLU_066963_4_2_1"/>
    <dbReference type="OMA" id="VGEYTFC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059050" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="23840" checksum="127660866D6D42F5" modified="2015-03-04" version="1">MKLFNIFISLLVYSVPFTDATALTYKIAANENACFYATVKNKGAKVAFYFAVQSGASFDIDYDVTGPNKKVIMNGAKERQGDFVFTANEIGDYEFCFSNRISTFTEKVVDFEIAVENEERATIPNLQNVAPEQTSALEESVIKLSSQLSTIARNQKYFRTRENRNFSTVRSTERRIFNFSVMESLLIICMAGLQVFIVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBZ5</accession>
    <name>A0A0B1PBZ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase family 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000643">
        <property type="protein sequence ID" value="KHJ34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBZ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBZ5"/>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="OMA" id="WWPSANV"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080597" evidence="1">
        <location>
            <begin position="22"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="43005" checksum="BB4DB92DC24EEA31" modified="2015-03-04" version="1">MFSHSYLIFAAIFAGLGLSTALPYEEDTGFHQIKSRMHKRNDQRENYSAYAVAGINQLQTWYNTNDGLWDKAWWPSANVVTMMAGLQEYFPSAINQMTDIVFPNTLINAQKTFPGFINEFYDDELWWALAWIKVYDITKNETYLQTAAGIFEDSKSVWGQTPCGGMWWDKNHTEVGAVVNELYFTTAIKLANRMPSTPWPAYYMDEAVRSYTWFRESGLINGENLINNALDLTTCQNDGNYVFSYNQGILLSGLAEMTWATEDRQYADLADVIASATINAMTGSDGILREPCEPNACNGDQEQFKGIFSRNVQFLYKRNSYLPPETATLYKDFLQRNADSIWAKNNIDNQMGLVWSGPRGRVSVQTQSSALDAIVGAAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC04</accession>
    <name>A0A0B1PC04_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative rna binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000635">
        <property type="protein sequence ID" value="KHJ34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC04"/>
    <dbReference type="STRING" id="52586.A0A0B1PC04"/>
    <dbReference type="HOGENOM" id="CLU_005652_0_0_1"/>
    <dbReference type="OMA" id="MWEISQG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="439"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="582"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="644"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="717"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122501" checksum="A75AE0F43084FFBB" modified="2015-03-04" version="1">MSPRTEHPTLIFLPTSQNLGRSGASTTNTSPIENSGSNGPQRPPYLISGGLNSGNKVTSNSRSGAGSPSHDLGNSNRIYSKRAREIQAQEGVQMNVWGPPTSGNSTPLRENIPESPTDGFPDFSRQSVQEIQPNSSRRARAGTVPSRFSPGGVCTGVNVPPTMAMNSRQTPPSSFKSSSPVSSEHIDNRNAALLSRLRAGSMPQRSQYLSTSAGPFGPSVFSTNWSSGRERTSTLTSIASQGSNNQNSPSPSAFLRETMGNNDMQMRTLDYLGLADTPQPQRATMVNPLLANIANITKQANRFRSYSVNAKEKYAEDEEEYVTGNMTPFEAQQAQLHMQLAATHAAIQQHNLAVQAYASQASASRPRARTAGILDSPASRMMMNHYANSRMDSGVSVSNLGLNDDYDELSQNVAAMSLGRSTSANEHLNPEDKSEGPTRALWLGSIPLSTTVSTLTEMFKPHGPIISARVLTHKNCGFVNFERLESAISAKALMNGKEIFPGAGPVRINFAKPPSPTGTPDSESHIPSTSPDLFAKGEKDIDINLNPNDFSRLEATTLSIPALADMKQKILKIVVEFGASPDEKSKINDCIDASISFTGYQSEIPPIPEPSHSRIYDAPKLRDIRKRIDSQNLSIAEIENIASGILPEIFELSSDYLGNTVVQKLFEHCSDNVRDIMLVEIAPHIAEIGVHKNGTWAAQKIIDVCKTPKQMNMIVKNLQPYAVPLFLDQYGNYVLQCCLKFGSPFNDFIFESMLSQMWEIAQGRYGARAMRACLESHHATKEQQRMLAATIALHGVQLATSANGALLLTWLLDTCTFPQRRSVLAPQLIPHLVHLCTHKVAYLTVLKGINQKQEPEAKDMIYKAIFFSPNDEVLEAILSDYACGATLIFKVLTTPFFDESIRSDVVENVRKVLIRLKAQPAQGYKRLMDEVGLSRGVSSGPTREHVPSNTNERARPTSNQDQISNMQRLPQQYGNMFFPQIPPSELDMGLPRPDGIDSNLPPYLPYSPMFNSPNLPPLNLQQLQYQQSLLARATSPMNNVHPAIQPGFYGFNNGSPGPEHFRDQITHPIMNLGPSAPPGFNSVGVGQGGYGFNGMNGTSAAYGMQTQEPQINGRVRRVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCN7</accession>
    <name>A0A0B1PCN7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative px domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000885">
        <property type="protein sequence ID" value="KHJ34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCN7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCN7"/>
    <dbReference type="HOGENOM" id="CLU_007739_1_1_1"/>
    <dbReference type="OMA" id="MGWLEGI"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="179"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="908" mass="104327" checksum="AC7A933E09EF4B5B" modified="2015-03-04" version="1">MQKSDSLPSSEILTGRQEHYLKRELISQQVKAEITELNCPTALQRFGAPFKSEFGEVSPLDSDLPILRYIFVHFVRKFPFLDHAREKEFWQDKLQVFLQSFASKHISSSEDRLEETKRRKLSIKCQKLVELMMVSGIPTASGYEERIRFSDLEVVDSGAIDHGIMHTLPEGHYVNGWDVNIAGVRAVNGRRKLIHHKHTEFILRVKRKGEPEYFIGKRYGDFDHLYKNIILQLPGKVIPSLPRKNKSKSSTSAIVSNLLKGRAENEASSISSVSTESFPSNSLKDHRWMTVTSSKSSLSPRSSIEERLCSRSSLNTSRGTKITDDKPFYFCREDQRISMRAFLRTLLSNDQIASSNAMNDFLTSGPISLTDSDKHDISGRKVLDELRVEEQKKFYEIARKRAIELDVYMEEFRRNIIESNGLSKLLQEVKDKPSIQDLSFQYRKFAEWLRIEVAATIYHLFLAEDNSPELFAQAKKIHSMIPYTIVKNAIRFANPAAVMSSILDIFLAKPFGTRSLMQRIFALTLNDGIRSLQKNINTINDEIGEFTFSEKIKKFCNSDESVRIVIRQESENDNVDLILAILRSELIPPRLNPTQIGKIFNAYLAWNSAVSNIDEEVKSGALHFSYLKQLLKLYTRQRDKAMMLSMIEEPVTLQLFRDLFTIFYEPLVRVYKTANVYNRVTDLADFIDDMITVIDRAREQDFSADPNQTVQAFIDLCARHEDNLYGFIHEIHTHDDGLFTQLIDWIESIIDFLRNGPKAGKIDMNSLFTESISSGRLNKDVAIDEIDKLIAWQEARKKWHQDKTRQKMAADGSSSIINKVPGSGTFRSSDFGLHQMDLEEMNYDDAEQSSLDEDQDDLSTIMAERRLRDHANQANLRRTAGEPVKPKITEIYKIKDEFLVMLRSVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCS0</accession>
    <name>A0A0B1PCS0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000502">
        <property type="protein sequence ID" value="KHJ35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCS0"/>
    <dbReference type="SMR" id="A0A0B1PCS0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCS0"/>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OMA" id="KLRVDQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902854">
        <property type="term" value="P:positive regulation of nuclear migration during mitotic telophase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905758">
        <property type="term" value="P:positive regulation of primary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="258"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="562"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="660" mass="75749" checksum="88706F25F2140954" modified="2015-03-04" version="1">MPSFITNLFPSTQTGKFENITPLPPHMSFSERPNTPNRNDFITPVSTPQGSPSKTKNPPGANELPIAFENAMKLAPTKIGSPIKYGHPQLQSPLSPTKGNTLSVDDSYLNNSDTHKNPKKNTASSPIIKYGKENSPASAWQGIETNNVANPRHELHQRETNASKYNTKRVITTIEHDILQKPHVKRLSNVTQLYFLDYYFDLLSYIGSRQNRLNLFKAEFPEPPKTPEDVYKPAWQKYTGRERANLRKRRVRLRQGDFQILTQVGQGGYGQVFLAQKKDTREVCALKVMSKKLLFKLDEVRHVLTERDILTSAKSEWLVRLLYSFQDEKSIYLAMEYVPGGDFRTLLNNTGVLANRHARFYIAEMFCSVDALHQLGYIHRDLKPENFLIDSTGHVKLTDFGLAAGFLAPGKIESMRVKLEKVGEKYVPFSKPMNQRTIAERREGYRSMRDKDVNYAKSIVGSPDYMAPEVLKGEDYDYSVDYWSLGCMHYEALTGFPPFAGSNVDETWKNLKHWREALTRPVWEDPNYFISNRTWHFITCCITSRAKRFSSINEVYEHQYFNEVDWKTLRTKRAPFVPELDSETDAGYFDDFSNEADMAKYKEVHDKQAALENMADREDQMSKSLFVGFTFRHRKPATDDSGRFSPKKSTISGETFGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCS2</accession>
    <name>A0A0B1PCS2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000862">
        <property type="protein sequence ID" value="KHJ34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCS2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCS2"/>
    <dbReference type="HOGENOM" id="CLU_023524_1_0_1"/>
    <dbReference type="OMA" id="SHADPMI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="61517" checksum="63B04A0CFF70C6D8" modified="2015-03-04" version="1">MSRRPPRKSTLTQQQKNQKRQRATQDQLVTLEMEFNKNPTPNATVRERIAEDINMTERSVQIWFQNRRAKIKLLAKKSIETGEDCDAIPDSMRYYLAMHHMDSGKGLSGDYSGRYGLLPYGGNGLMMGNDQGTHNKVVIHHLNCRSLSIGSWRRIGQNAMDLIVFYSPEKRTMTYYINNDQAGYKIEYPFSYIKNISLETGEVDMARPAGLVVELTRPPNFFMDSSGSGGFFQCGDFTEDQQASQTLVHHLGGHPKVLSGQLAKLVSLEPFMHRHDVYEEQHLSVSAPVSPTGQRPSSQPNYNAPPHVGMYQEGWGVNLHASQRGSGHKRQRSRSVPTAIDFSTFNGHIPSLFVQNSNEHESSTDPNIYSPVPQQTNNLGALGPNLRIDTSTGYGMDFRQYPLSATTINSPSDFASPGFFQSGPDSAALSSSFSTSTPTGISYLTPNPMVDRNGSLIQSAASPLSFMSHADPAIVNQSPPLAIMHRSPSADAYAMTHGYSNISDDGTSLNEMYLKHNINLSMASPAFPEHTELDMNQLVTFDESNPSLSPEQIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCV4</accession>
    <name>A0A0B1PCV4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc knuckle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000492">
        <property type="protein sequence ID" value="KHJ35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCV4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCV4"/>
    <dbReference type="HOGENOM" id="CLU_720009_0_0_1"/>
    <dbReference type="OMA" id="TTERNME"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="43908" checksum="7A3CAE69B3A4409C" modified="2015-03-04" version="1">MTTERNMELILPEGMITWQSRGSQSTLDLAFISKQLLGTVIRCQPSAELESSSDYIPVITELLINPPQKPETKPKPQWKKACWDAPNFKIATKLSELSTRELHLSTPEAIDQRVAEVTQVIQESIKELVPKPAPTGFSKPYWTLKCSQAVKRARRARRRWTDVGNEESWAAYCKVTNSKKNQIRKEKQIGWRATVTEATKDPHKIWKLTKWARKHPYEKHNTPQIPETIDKNDTIHSNSKDKATAMTSHFSPHPRPADTSDIDEYEYRREIEDIPQTVLSSELEEALTRHAEGKAPGLDQIPGTLLKHCRTALTKELTKIFNACLLQGYHPRKFKESITIVLSEIPEAKLQRPKLVPSHSAAEHYREASRKIDSQPTRDCCRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD8</accession>
    <name>A0A0B1PDD8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000430">
        <property type="protein sequence ID" value="KHJ35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD8"/>
    <dbReference type="SMR" id="A0A0B1PDD8"/>
    <dbReference type="HOGENOM" id="CLU_1267736_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059570" description="Secreted effector protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25146" checksum="D5BB011A5A512E33" modified="2015-03-04" version="1">MYKMRVNIFLTACLSLLPAIFASHDTNPPGIRFYRPRSDHSSRVEAPRELNNPDILLRNTNELISELPIRKSPPSNGVENKNNDNNGYSCRCTLYSLAYLKKVAAYAKKRLYQNNKQPYPVEFEPRLYTYMYPLHENRRSIWLKGNPEPRDFVVFNAIGQALYAVTAGSPTSKKSHHQCWKVSEILPHCSPSRFEKLKPNKSLTSPFSAIRNLFRGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ9</accession>
    <name>A0A0B1PDJ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000564">
        <property type="protein sequence ID" value="KHJ35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ9"/>
    <dbReference type="HOGENOM" id="CLU_062645_0_1_1"/>
    <dbReference type="OMA" id="MENRTDR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="211" mass="24058" checksum="55EFAD13F1330503" modified="2015-03-04" version="1">MENRTDRDLSEYDQIRYAIRSGIFKFPIKAFLSTFVLILNESSFLITLIYRSFLQNSLAQTFDAVLAANKQTHLLSGRRELKVGYFNDPVTKLGALIRLPIGVLSSETLAGYLSFLPLALIPIFGVYIFIGVQAQARGCIVHNRYFQLKNWNRSEVNEWIYQKAAQYIMFGLVASALEMVPFVSIFFTFTNTVGAALWAVDIEHQQLKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDK3</accession>
    <name>A0A0B1PDK3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative manganese transporter smf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000558">
        <property type="protein sequence ID" value="KHJ35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDK3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDK3"/>
    <dbReference type="HOGENOM" id="CLU_020088_4_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="643" mass="70884" checksum="6CDABCFF42035964" modified="2015-03-04" version="1">MNSLSRKHDKEGSTYGQSLTAFVSDLMVRKDPNGRANSRIMTSNTNHEPNCEKNITHSMKNNMSDGSSDRDSDYSDEEDGDFEKRDSEKEFKRRDEERKDEKRRYQSGRPRTIEDEKEGYDEKGFKIEEHDDIEKRDYLKNKLEYLSDIKLSKENVWNILATIKEYLKFVGPGFMISVAYIDPGNYSVNVTAGATFRFRLLYMGLISNLFSIFYHGLCVKLGSITGLNLAEACRTFLPRWLNIILYVIAEVSIIATDVTEVVGTGIAVSLLLPKVPLQLACALSILDVIFIRIVSGPDGKLKGLRAFEFFVMALVMGVVTCFCIQLCIIKSPNVGEVLSGYIPAGELLQPQGLFQACGILGSTLMPHSLYLGSGLIQPRLKQFDIDNGLIPSEPDLSRKDRRVYKPSLDAINTCMRVFITEVIICLFIFALFVNSAILIIAGSSLYETPGSNADLFGIHDVLSTTVGPAAGTIFACALLLSGGSAAIVCTLAGQMISSGAVHGNVSPWLRRLLTRAVSTMPSIIIASMSGRQGLDNILDAAQVLLSLLLPFVIAPLIYFTSLDRFMTVRTPVNCIQSRSGNRTGSVGWDAEALPPLETRMGNHWFTTTIAISIWLCIIVLNVTNIFQKVFSSSGILHGGTLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEN1</accession>
    <name>A0A0B1PEN1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000427">
        <property type="protein sequence ID" value="KHJ35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEN1"/>
    <dbReference type="STRING" id="52586.A0A0B1PEN1"/>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OMA" id="LWNVIGT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="188"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="382"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="668"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="790" mass="87962" checksum="8359213D9070998D" modified="2015-03-04" version="1">MGNENEKYNEHIPLLSESTLVLHQHFFHPIKRYTQHERVNIIVVIFLILLLPIALLSHYGRQILRHHSLVDYQELQSILLTTPNEDHAREWSSYYTSGPHLAGANYSQAAWTKDRWQEFGINAEIVAYDAFLNYPLGHRLALFEKTETDSWHVKYEASLTEDVIKDDLTTGLESRIPTFHGYSASGNVTAPYVYVNYGTYADFEDLIQANISLAGKVALVRYGLIFRGLKVKRAQELGMAGVVMYSDPGDDGVVTEENGNAAYPEGPARQPSSVQRGSNQFISTCLGDPTTPGYSSKPGVPRQSVENSIPSIPSIPISYLDAIPLLTMLNGHGPAAKDLNNWWQQNLGLRSHGINYNVGPSPSGLSLNLVNKQDYVITPIWNVIGVINGTLSNEVVVLGNHRDAWIAGGAADPNSGSAALNEVIRSFGLALSKGWKPLRTIVFASWDGEEYGLVGSTEWVEDHLSWLSASSIAYLNVDIGTSGNKFKAKASPLLNRVLFEITSVVPSPNQTILGQTVADLWNNGIRTMGSGSDFTAFQDLVGIPSLDIGFEEDLSRIGEGSAVYHYHSNYDSFHWMNTYCDPGFYYHTTMAKIWGLITAKLVETPVIPLNATDYAFALKLYLHQNEAKITGFSSGLISEKELIAARTRPTLGAPCGLISELKILINKTYLAIDKLELAARNHDALAADLASEIRQDFPWWKWPRKIRLQYHIKKVNDKYKYFERAFLYSKGLDGRPSFKHVVFAPDIWTGYSGSVFPGLSESINKKDWENAGKWVEIIRECIVKARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF24</accession>
    <name>A0A0B1PF24_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pul domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000481">
        <property type="protein sequence ID" value="KHJ35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF24"/>
    <dbReference type="STRING" id="52586.A0A0B1PF24"/>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="OMA" id="VTLQMAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="4">
        <location>
            <begin position="287"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="574" mass="63705" checksum="F3FFEA851083CB03" modified="2015-03-04" version="1">MIDVQLYIYDLSNGMAKQMSLGFLGEQIDAIYHTSIVMNSLEYVYDGGVKIVSAGKTHLGPPLKTVFLGKTELPMEVILEYLESLKEIYNEKAYDIWTHNCNNFSNDFATFLVGHGIPSYISNLPETVLKTPFGQMLKPYIDQIARQAQANKGGLLGIEGTAESRPSNENRNLVHLASSVNELDNYLQNSQNFCAIVFFTSQNCGPCKALYPLYQKKAIEFEEVIFLMVDVAKSIEIGMKYSITATPTFITFLHGSQESRWTGSDPSSLHSNLKMLLLLAHPSHPHESLPLPEFFSADSQPILYTKMPPLSKLKVKLGPCAENDVVLEILNFISSGISEESTKLPCPDLNAFSKFLWSAPSELPLEVLFAIVDLFRIGLADPTFNAYFTNEKDHKTVALIISHVNCLENCPYSLRLVTLQLSCNLFLNEKYQHNVLGCASLYEPIIQLATNSLLDDKNQNVRVAAASLAFNLAITNQKARFDKKNKEILPEAQQLELAASLLEAINAEEHSAEALKGCLLALANLVFRAPKDGELVDLLKSMASNEIILSKQNHFPKEPLIDEIGNVLLGKGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFE7</accession>
    <name>A0A0B1PFE7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative duf28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFE7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFE7"/>
    <dbReference type="HOGENOM" id="CLU_062974_1_2_1"/>
    <dbReference type="OMA" id="NFDIPDE"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="38"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="117"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="296" mass="32857" checksum="EE9D15081F9541AF" modified="2015-03-04" version="1">MAIQLRRLRKSQFIDSFSLWGNCHLFFSTTSILTSGHNRWSKIKHEKGAADAKKNRVRSSIAGELTLASKLYGPDPNLNPRLATLIANAKKAGFPKISMEAAIARGQGKSTTGSNLESLMLEAIMPPSIALIIECETDNKSRTLMDLRFKIKYHGGIVTPTSYLFNRKGKLVFEKSDKIRGLDDVLDAAIDAGAEDVDTMGDDSIVIWTEPSKTFSTLEQLQSVLDLKVKSSEIIWDANRDTVIPLRDIDELKINHLLDLVDELQEYPDVQGVFANVSKGTLSDDQWTELMSGLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFU1</accession>
    <name>A0A0B1PFU1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxin 11c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000289">
        <property type="protein sequence ID" value="KHJ35731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFU1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFU1"/>
    <dbReference type="HOGENOM" id="CLU_052213_0_1_1"/>
    <dbReference type="OMA" id="RNLAWAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="300" mass="34415" checksum="85E15A16092F1126" modified="2015-03-04" version="1">MARLDEEKLKDPENKDEATISAAALSPKLPLVAELSNNTSCFLNKTDQTISHLSRILSTPSGTDSLLLTICYTSLLTSTILTSISLARLRNTVRILINKALTLPPETTFVLTMKTIPSSRLLNLSMRLKALSSLVSDVRIFSRLWGLITIWTWAKSAFKENPNEDWALNQLEKSQVIASIGYQFLENHAYLSSKGILGWSKKKQEKAWVWSSRFWALYVMLEFIRLWREKRVREEKGKYKINEKSQWISDWEKRVLINTVYAPLTVHWSLEKGLISDFFVGLLGSTVGMIKMRQVWNKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFW7</accession>
    <name>A0A0B1PFW7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5161</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01000377">
        <property type="protein sequence ID" value="KHJ35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFW7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFW7"/>
    <dbReference type="HOGENOM" id="CLU_000995_6_1_1"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000030">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="302"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="685"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="906" mass="101030" checksum="0112C4E496DE94C3" modified="2015-03-04" version="1">MESIQLRDEAVRDRVRAAQEFLDPSDLSLRSYRSEIILMLQKNDRRLVVSIDDIRSRNSELADGLFNQPFDFSQAFDRALKEVIQTLPNTTPIQTSEDTMYYCAYSGSFGQYACNPRTLSSSFLNRMVSLEGIVTRCSLIRPKVIKSVHYNENKKVFHFREFKDQTMTMNGATTSSVYPQEDESGNPLITEYGYCTFRDHQTISLQEMPERAPAGQLPRGVDVILDDDLVDKCKPGDRVQLVGIFRSLGNVHSGSGSALFKTLILANNIVLLSSKSGGGIATASITDIDIRNINKVSKKKNLFDLLSQSLAPSIYGHEYIKKAILLMLLGGQEKNLENGTHLRGDINILMVGDPSTAKSQLLRFVLNTAPLAIATTGRGSSGVGLTAAVTSDKETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPIFGQYDTHKDPHKNIALPDSLLSRFDLLFVVTDDIEDTRDRQISEHILRMHQYRQPGTEEGAPVREQSQQTLGVGVEVDTNRNTEVYEKYNQMLHAGVTVTSGRGANKRVEVLSIPFVKKYIQYAKSRIKPILTPYAAERISEIYVALRNDDMQGSQRKTSPMTVRTLETIIRLATAHAKARLSNRVEEVDALAAETILRFALFKEVYEDEKKRSKRRKIRPLEDIESSSESNSDSDSSSTVVRSISTRSRTTPHLRRGRAGSIIGAKNSTNRSNELFKDSNRIQEEEREDDEQNIYHSSPRNNTQRFLSNDPTTSHDTQPSFASSIPFSQIETQIQTSHARTEDDLLASGTASLSLKTPGVTSTRLNTFRTNLGQLLNTDLFQDDCATVISIMDAINHRLLLNTTASTANSDDPFSKDETLAALNEMKAKNQIYVDDNEIVYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFY3</accession>
    <name>A0A0B1PFY3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000268">
        <property type="protein sequence ID" value="KHJ35766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFY3"/>
    <dbReference type="HOGENOM" id="CLU_1918620_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14950" checksum="F6175B55A74822BE" modified="2015-03-04" version="1">MARFTSNSKSSDLKKSFLLKLKYSRNHKKEKKAEKSCCPIKKATGTLRNILCCPDSEEPADEVADTSYWPVRVAYEPPNQNLFLGSQGLSLYQMGGTCFQPTLEPAPTPRHKTRSGRVRIHDNKVVVINNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGE5</accession>
    <name>A0A0B1PGE5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nad dependent epimerase dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGE5"/>
    <dbReference type="STRING" id="52586.A0A0B1PGE5"/>
    <dbReference type="HOGENOM" id="CLU_055314_1_0_1"/>
    <dbReference type="OMA" id="WERADIF"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="32069" checksum="7AF909F838EC49BA" modified="2015-03-04" version="1">MNETRMTTAPIKIVVCGGNGFLGSRICKFAVARGWDVTSLSRSGEPKWASVSSSNTPPAWAHEVHWERADILKPTTYSPLLRQADYVVHSLGILLEADYKGVISGQESPITGLKRAFSQTRLSSQNPLSPRKDTDLHSQEKDDQLTYELMNRDSAITLAQEAAKNGASVFAYISAAGGAPILPQRYITTKREAESTIASEFCKMRGIFFRPGFLYNSSRTFTIPLAAMTAAGAAFNSLTGGIFSNFMGAAGTKPLDADVVAEAVVEALNDESVKGPVEIKEIEELSRRAWRKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGI4</accession>
    <name>A0A0B1PGI4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tafazzin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000177">
        <property type="protein sequence ID" value="KHJ35976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGI4"/>
    <dbReference type="STRING" id="52586.A0A0B1PGI4"/>
    <dbReference type="HOGENOM" id="CLU_032824_1_0_1"/>
    <dbReference type="OMA" id="GTNYYSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="470" mass="53069" checksum="23EE68A743EB9D95" modified="2015-03-04" version="1">MPRKRFNTRYSKPASTTHSSLVSTVSSLSNKSYQQPTVNELIESLRRSDLASIRASSAIVNIPTLPPELRRLLAQPEIPVPRPRFRNSGPLDINLGTTAAGPAAPRSWLSGQLNCHPRSQEHNREKRNLSFHIDHLPGLFIIPKTSLREQCLRALARNWDFIKEYEKNYLAYLPTRLRSMLLSHIAVYGPKTGVGFSGLKNLIFLTDSETDDSYSSYRHNKNFSRLDLSGAIGSSLSIEQVLGLVRYKSENSAGSSNLSWEDNLDLSTSLSPPLSHLTHLSLSHPPTNVSWSALLSLVANLPTLTHLSLAYWPLPISVLKRKLAIFNDILNEDDKVYNRNQSTEVLDEYFSEATRVLRNLANRLPGLEYLDLTGCQSWFKVLVAYSTEDLYRGIEWGKSWTQLKTLKLNSGIEVTKESQDSEVQNRMQIYELAVAVENKIISLLRQAKIHGMKFSWINVIKDDLDNLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGJ3</accession>
    <name>A0A0B1PGJ3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000054">
        <property type="protein sequence ID" value="KHJ36365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PGJ3"/>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="591"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="696"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="819" mass="92119" checksum="93A40EE99113C1FE" modified="2015-03-04" version="1">MMASSRIFIKGLPPTITAEEFKEHFSKIATVTDAKLIPHRRIGYIGYPTQEDAAKSIKYFNRTFIRMSKILVEIAQPIADSLSKKIPACDQKYLKDNEIDSQRLATTLPNQGVKRKRVDNHESKHKLAEFLEVMQPASKCKVLDMQVSECESDLRKKVQVIESPFEKTPSESKIIIQKSIDGHPEISLPPKTQTAILPESSDNNSKAGASALTDDEWVRSRTEKIPKSQNSKEPQQVLLGINSKRDIDTIQLDAAKSHEEHEDPLQNSSIPQINDEEVIDASIEMIKKYKRLFVRNLPFTVTEEDLKILFSSFGALKEVHIPVNVSGKCKGFAYIQFVESMAAIEAFNVLDGKSFQGRLLHIIPGYAKREMTFDDSNFSNLPFSKQKHIKKKSQAASANFSWNSLYMDQDAVNSAIASRLSISKAELLDPTSTDSAWKQALAETSLIQESKAFFASKGVDLNSFKKHERGDKAILVKNLPFGTTSEDLRKMFEEFGKVTRVLVPPSGIIAIVEFALPGHAKAAFANLCYRRIKDLVLFLEKAPKDLFINVEEEKKVVLPEKTICLPKEDQKIVSISDLLEQENSPDYAQSSTLFVRNLNFSTTNERLVEIFKPLTGFISARVSTKKDPKKPGQILSMGFGFLEFKSKDEALAALKAMDGYNLDGHNLVVKMSRKSLDPAEERRKEDNMKKHSANKTKIIIKNLPFEATKKDVRILFSAFGKLRSVRLPKKFNHSTRGFAFADFVNSREAENALEALKNTHLLGRRLVLEFASAESLDAEEEIEKMQKKVSSQVNKVALQKLTGGGRKKLDLENNETDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGP0</accession>
    <name>A0A0B1PGP0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gpi anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000027">
        <property type="protein sequence ID" value="KHJ36420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGP0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGP0"/>
    <dbReference type="HOGENOM" id="CLU_680067_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080705" description="Gpi anchored serine-rich protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43386" checksum="36852083D950C32C" modified="2015-03-04" version="1">MKGLLAPLITAVVLIDAATHNPIQYFDQAEPTPAPFLNVGPNNAPQADIYQNKPAQNQVVEPASPEAVASKPEVYEETEDIDEPDSDNEELDIKTTPTTEFINATKTPEPTKDSVVSPDIEDDGLHKPAGIDFPDGESAEKEFDHVEFKTTSNYTTSTVYTTLTSTVTDCVSTVTVCPEIGSIVTKTISLYTTICPVTTPTSVAPPSNKSDIPNSDAPESDAPDSKGPDSDIPDTGSADQELESDAKPDTEEGAEQDEDAEPDAEEGVEQNEDEDEDEDEDDDSNVPQPTQGPYLTKTIETTVWYTVTDCAPQETECPVGKETSSISTLTETFPVTDLPRYSSPHSTQNQPYVTSSPSSYPKPPHTNVTVPTTPPNFTINAGFSQKANALLIGFGLIAASVIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGZ9</accession>
    <name>A0A0B1PGZ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mfs general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g3100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000136">
        <property type="protein sequence ID" value="KHJ36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGZ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PGZ9"/>
    <dbReference type="HOGENOM" id="CLU_1038277_0_0_1"/>
    <dbReference type="OMA" id="MDDANDP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="102"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="28815" checksum="CB0DF6F28FA1DF37" modified="2015-03-04" version="1">MSLPSKDSNSPYEVRSTENSNIQSHQGFSRWRMGILNDPLDYEVPGTILLLSEKHDGPDSPNPIEAEDKKKKTPDGKIVLNPQPEDHCNDPLNWKIWRKDAVLLSIGLYCMLGGGMTPILAAGYSNVASTFHVTVARVSLTTGLYMLGLGLGSFVVCPTAILYGKRPLYLIGSIIFVISSIWCAVASSFISLTLGRFIQGISVSPSECLPSATISEIYFLHERAYRIGIYSLLLLSGKNLMPLVSAVIIQSLSWRWVFWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH18</accession>
    <name>A0A0B1PH18_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000258">
        <property type="protein sequence ID" value="KHJ35784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH18"/>
    <dbReference type="HOGENOM" id="CLU_1074405_0_0_1"/>
    <dbReference type="OrthoDB" id="3584755at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="31031" checksum="79549A66050EBDC7" modified="2015-03-04" version="1">MSWFNLASPSIRYLTRDTYFEWMDKLQGYATQMFIWVYVDPDGETDLESSRPSFPEILHSYYDSHLIGSVENKRFEFEKIFEEYRMDLQLFRRNEAVIADLRNKIFEALHPNYRRLIHGEMTCREVLRVIKSYLEPTRAEQEHQIEYAFAKAHIVPPIKEVDTWIMEWERIEIIAKRLKMTNLIEKLSYDFGFVSNSLLPLSQRTGWRSIWDPRFGGFKREFSTVLDIFRRIWLECKLDFLKDAQGKSANSPESELSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI42</accession>
    <name>A0A0B1PI42_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative at hook domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000011">
        <property type="protein sequence ID" value="KHJ36461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI42"/>
    <dbReference type="STRING" id="52586.A0A0B1PI42"/>
    <dbReference type="HOGENOM" id="CLU_799726_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="38102" checksum="0826FA92B5EEBCDB" modified="2015-03-04" version="1">MDREVFSESEKRFLITQILQASSMSLERIFMLFNECSEEPRWEDIYLPIGRTLQECKAAFEAIRTTTSPFATPNSPGFNQAFFHKRKAGIGSLESSSSLSLDSKRRLSVIRGQDIGGQLILPKPSPTESMTSNPEGMFSQQLILPKPTLMESGTSISEVRSGHQHILPKPISPFDSGTSIPEVMVKKRGRPPKAEVERRQHAIARGEVNNPNTMVTQIRYIAPAEKSSIASSSTTSSQISSTSPKSGPVLKKSGPLRQPGEGRFSLNDYIRPSDRLSPSKPKKKALAVSTLAGPESSTTKVPVKTNSMVSSSPKTPISNIQSIEATNLETPPRKFDKKPFEGSPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI86</accession>
    <name>A0A0B1PI86_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fyve domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000114">
        <property type="protein sequence ID" value="KHJ36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI86"/>
    <dbReference type="STRING" id="52586.A0A0B1PI86"/>
    <dbReference type="HOGENOM" id="CLU_082207_0_0_1"/>
    <dbReference type="OMA" id="HCSNYFR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="229" mass="25786" checksum="AA93EF7319E7EDAC" modified="2015-03-04" version="1">MDRQRPQFGKGKSSTYLPAVLRAPEPPKCMEMESEQPPSPLSPIESIKSFWKFGSPKSTEVDLDVNFKNLSQEAIDLKGLGNVTGPPTRVHWKPDMFSRHCDLPSALCTQTFSVFWRRHHCRRCGLIFCHLHSLYTAPLDQDANFHPLGKPSRVCQRCMAQWNTWIERHSSIIKENTVGLNGQLKMEESKPLKIASFPKAPIKADQTLAVAGSSGMGKSVSSDWTWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PII4</accession>
    <name>A0A0B1PII4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PII4"/>
    <dbReference type="STRING" id="52586.A0A0B1PII4"/>
    <dbReference type="HOGENOM" id="CLU_014633_1_1_1"/>
    <dbReference type="OMA" id="KHGRKMN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="539" mass="60416" checksum="BBB68C73BC9633D5" modified="2015-03-04" version="1">MEVLVHDVLIIGSGPCGLAVASRLKEQTPGSLFSDSEHQRFHFMRASAQSRLTSKPIRLSRRSNIPAERLLSGPVIPSNNLDLVVLDADGDQWMHSWNENFKKLRISHLRSPMFFHPDPSDRDGLRAFAYVKGRMNELREIEGVVGKELSKHLRKQKQRKRSQKEIAYLDERFRDDYFRPSQALFKEYCEDIARRYGISDIVQRSRVNSISFDKNEEIFTLQTSTGEKKSRIVVLAIGSALDPSLPPDCPFCDAHNVAHIMSAKVHSNLLTNQDVKYRTNSVLIVGGGLTSAQVAKVVADEGISRIYLILRGKLKTKHFDVDLHWLAKYKNRSMSEFYFADSDQERWEMMKSARGGGSVNPEFKVIIENLQRKGTLKLKENTVIKNAIWESSTASWSVDLQTDEQEIEQILVNHVIYATGTPVNISSLPLIQPLMAQHPISTVGGMPCLTDELMWDEGVPLFATGKLGGLRLGPAAGNLEGARVGAEFIAGKVADLLPRWKDTEPPASSWNENLAKGISVDLRRLGLGQANQFEILTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIP1</accession>
    <name>A0A0B1PIP1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000070">
        <property type="protein sequence ID" value="KHJ36329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIP1"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="18090" checksum="18BB6CC23F327D30" modified="2015-03-04" version="1">MAYFTTAPRTSFRVFDESGIARNFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSINHVDELCMAATKNRNCGGPHRFDIRRCLARPTRSGAPTKEQMKTYRQAGEREYQAVLRAKTAEDLAASTQNEILDITSSEEPEAENTTNNSQAPLVESSTCGAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVK4</accession>
    <name>A0A0B1NVK4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01004385">
        <property type="protein sequence ID" value="KHJ30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVK4"/>
    <dbReference type="STRING" id="52586.A0A0B1NVK4"/>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="OMA" id="EQNCIDR"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070158">
        <property type="term" value="P:mitochondrial seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="286"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="58789" checksum="F3E5BF6FA2551158" modified="2015-03-04" version="1">MSLNHILKISQRNYVCLRCRDNLSRQFFLRFFHVLPRLRRENLNSFIAPKAPKALINIKHIRDNATLHEQNCLDRNYRIQATYPSKINSLTERWQSYQKSSRSLREKSNWLTRQLASKNLPLDVNSNPSENEEFSRQIYLTEARHLKEELTSIDKEQSALSAEIFQLALAMPNLTSCKTPRGSIPKELGIINEQIGLNSTCSNQHCRSHVDIGQELNIIDFAGANTTSGWGWYYLLNEAALLEQALVQFSISIARKRSWSVVSPPSIVYSHISDSCGFQPRDQNGEQQIYQIQQHPADIGRKPQLSLAGTAEIPMASMKANQILDASKLPMKYIGVSRCYRAEAGARGANSKGLYRVHEFTKVEMFAWTLPDNAASNNIFDEMHSIQQEILGKLQLHCRILEMPSTDLGASAMRKIDIETFFPSRQAREGGWGEVTSLSICTDYQSRRLATRLRLQQSGQTEQFQFPYTLNGTALAVPRVLAAILENGWDEKRGVVLIPEVLWPWMNGIREIGPKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWN5</accession>
    <name>A0A0B1NWN5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 26s proteasome regulatory subunit rpn-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004390">
        <property type="protein sequence ID" value="KHJ30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWN5"/>
    <dbReference type="STRING" id="52586.A0A0B1NWN5"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079566" evidence="4">
        <location>
            <begin position="27"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="35778" checksum="F3324A9B698F19AD" modified="2015-03-04" version="1">MPTTTAETLSLVWLNVSVAPLVLLSAADHYGRSAKNTRKRVVGVLLGQNDGRNVRVSNSFAVPFEEDEKDPSVWFLDHNYVESMNDMFKKINAREKLIGWYHSGPKLRASDLEINELFKRYTPNPLLVIIDVQPKEAGVPTDAYFAVEEIKDDGTTTTKTFVHTPSTIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITNQLQSLQGLHLRLQDIGNYLHKVLDGSLPVNHVILGNLQDVFNLLPNLFTPKAPSASSDGYDTTLKSNSELAHAMGIKTNDQLMAIYLSSLIRAITAFHDLIENKIQNRQQQDESEAKNFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWT4</accession>
    <name>A0A0B1NWT4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004257">
        <property type="protein sequence ID" value="KHJ30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWT4"/>
    <dbReference type="HOGENOM" id="CLU_2322093_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10652" checksum="58B8CEAA9491F1F4" modified="2015-03-04" version="1">MHFLQCLIKVTLFTSLTTLSVVSIPVLSNLELKSTLYNDGKVLETRASTGIASLEQKAVNEIGKTVGKTIGKAFLGIIKDSVTKSAKKEAKKTVQKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWW9</accession>
    <name>A0A0B1NWW9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01003544">
        <property type="protein sequence ID" value="KHJ30837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWW9"/>
    <dbReference type="STRING" id="52586.A0A0B1NWW9"/>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="58521" checksum="3D2565E65F185A61" modified="2015-03-04" version="1">MQYNLMEISILKKFIGDFSSNKVFQPLLHLRFVRGSNGGYKVRRSISSTLCRNRKPDVEWQQRTDIWPADKSEEFQRYPIVTAQQLRGRRDRPRRVKMLMRDFIEDSLYNPSYGYFSKQVVIFTPLKPFNFNSMKDEPEFHRILGQQYTFFENELDLKDQNELRQLWHTPTELFKPYYGEAIARYLVSNYRLVQYPYEDLIIYEMGAGNGTLMINILDFIRNTDPSVYSRTKFKIIEISENLARLQHQQLFRNADARGHLKKVEIINKSIFEWDQIVASPCYFLALEVFDNLAHDCIRYHPMTEEPLQGYVLIDSKGEFYAFYSRVLDPIAARFLQVRHAATDGQYPRPLPSKALRNVMSYLPFTPNLSDPEYIPTRLMQFFDILAKFFPCHKLVTSDFHTLPDSVKGINAPVVQTRYQRRVVTVSTPLVHQGYFDILFPTDFSVVAPIYMAITNKLIRVVSHEEFLQTWAFVEETETKSGENPLLSWYKNATVLTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWX2</accession>
    <name>A0A0B1NWX2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative snare domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004178">
        <property type="protein sequence ID" value="KHJ30473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWX2"/>
    <dbReference type="STRING" id="52586.A0A0B1NWX2"/>
    <dbReference type="HOGENOM" id="CLU_042423_0_2_1"/>
    <dbReference type="OMA" id="HPRNAPQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="364" mass="40927" checksum="70705A7974F3DA0F" modified="2015-03-04" version="1">MTPYGGGRTIAPTQQYDEMGAYGTPSPNYGGPTMGRDDYTGQNVEMASLAQNGSQFGQQANPNSILNSCADVNRQITKINETIASLQIMQKSSLDAVSDMQQKRARKQIDDLSSEIMSLFRKVTGDVKMIKQQPEASSSKNAPQVERLSREITKVRRNYEVSDSNYRKELEAQIARQVKIVRPDATDQEIRAAVEDPNSQIFSQALLQSDRQGQAQSTRNNVRQRHEEIQKIESQMIELAALFEDMNNLVIQQEEAIINVEMKGEEVVENVDKGTEELGVAIVSARNARKWKWWCLGISVLIFIVIVIIILVYKFIVTAPVQVVAPSAQKPAKRFYIPNSPVDIKSALFPRAKTQPLRSRYYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX98</accession>
    <name>A0A0B1NX98_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transducin wd40 repeat-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003892">
        <property type="protein sequence ID" value="KHJ30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX98"/>
    <dbReference type="HOGENOM" id="CLU_1817232_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="142" mass="16045" checksum="2C7E60E639716552" modified="2015-03-04" version="1">MDFSKSSIAKLAGSSNYQVWAIKMKSYLIAQDLWKVIQLKTSTHTNSNIKSQNSKVISLIILACEDHVIKLLDPDDLAATAWKKLEQQYGHIGFSARHLAFQSLVSTNISSCESVDHFIDQFRTNMNTLSQRTTSTLPQWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXA9</accession>
    <name>A0A0B1NXA9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2871</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01003323">
        <property type="protein sequence ID" value="KHJ31027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXA9"/>
    <dbReference type="STRING" id="52586.A0A0B1NXA9"/>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="16">
        <location>
            <begin position="72"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="449" mass="50406" checksum="069B8D8DF92720E5" modified="2015-03-04" version="1">MSLSRNSIFESTIKTTASKNDFLRTNCNISYSKNESNLPQNLIRQALQCRVESIDHSVCDAGDEDTFFVADLGEIYRQHIRWKINLPRVRPFYAVKCNPDPQVICLLEKLGTGFDCASKAEIEQILNIGVDPTRIIYAQPCKTNSYVRYAASRGIKQMTFDNTDELYKIKKLYPEAELFLRISTDDSSSLCRLSLKFGAAIDSTEQLLDLARELDLSITGISFHIGSGASDPLSFRKAVLDASIVLNQATARGFNLRTLDIGGGFTSENFELMAATLNKALDDYIPFHINVIGEPGRYYVSSAFTLACHVIARRTVEDFVTKKKSYMLYLNDGIYGNFSSILFDHQVPKARVLRTSNITYFDDKAAEQSVDGIEYSIWGPTCDGIDRISERACFDHIIDVGDWLYFENMGAYTKCSATRFNGFTNSHDTIYVISEPKAKALLGKDSLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYC3</accession>
    <name>A0A0B1NYC3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4897</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01002957">
        <property type="protein sequence ID" value="KHJ31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYC3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYC3"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OMA" id="CSVGRPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="38732" checksum="A854C7F705150EA8" modified="2015-03-04" version="1">MAKSIEVIQDNLSFVLNKPHDVSFVQQPKPELESPHDVIVAINYTGICGSDVHYWHNGAIGNFILKEPMVLGHESAGTIVSIGSGVKTLQVGDRVAIEPGTPCRRCEECRAGFYNLCLDMKFAATPPYGGTLTGFYAAPEDFCYKLPPCVTQQEGALIEPLAVAVHIIKQARLKPGQSVVVMGAGPIGLLCCAVAKAFGASKIVSVDIQSSRTEFAIQFSATHTFIPDRVSAEENAARIIEQAVLGNGADVVIDASGAEPSIQTSLHIVRRGGVYVQGGMGKPDINFPILALCIKEVTVRGSFRYKGGDYKLAVELVSTGKVDVKKLITNIVSFHEAEQAFKDVKNGKGIKYLIAGPNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYG2</accession>
    <name>A0A0B1NYG2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002909">
        <property type="protein sequence ID" value="KHJ31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYG2"/>
    <dbReference type="HOGENOM" id="CLU_500550_0_0_1"/>
    <dbReference type="OMA" id="MNCHILL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="497" mass="54284" checksum="454507F3BBC83C9F" modified="2015-03-04" version="1">MTSILEQAIEPLLCLNGAGYFSEEEWIQLDHIIHKKYVWTTGPKSRFHNAMKAGYSASKLVRPEAKASVPSVSENEGIRISESSEGTSSGTSLAPSLDGVGTSNASAEFSWELSPAMNSPAPIPTSTPVKAIIRGKANTPKDLQSNGPTAGYTPQLEETQRLNSSLSKNKIPTVLPLVRQKGIAAWVSAARHGLPPSTCPQPTPIPSGNLVELEDNQAVDSAFEPKEIIVNFHKDVNAFETNNAAEWDEEPVSHEKMSDRDVIKADFEEKIEKRKKLDNILVRESQILKDVVHSSLPHTPPTSPPLEDRSMIRTATVTRSTRRGNPRVSTEPRDPTYIPPLPKTKTCWFWAESVGGCRYRPEECLNLHVKPKPGMLPNYPLKDGKPTWGCLADATPLEVPEGKKPRSCWYWATKGVCGHGTACKYVHGWVAGGVAPRPKNLVVDSSDEEDSDDSDDDDVDLSGRDIGDKAPSQAINMTPGFIASRVHATGWNLTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYK2</accession>
    <name>A0A0B1NYK2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative splicing factor 3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003302">
        <property type="protein sequence ID" value="KHJ31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYK2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYK2"/>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="570" mass="65384" checksum="4775796B3325465D" modified="2015-03-04" version="1">MRRIRKKEEKKKTSTNNNVDINPTKNETEDSKVASAVRSDQEEQEQEQLEIETFEVGEDDPNFTMYKQIIERFKVVTEDYETKKEGNATDKGEVFYDDDNDIPDEEAEEEKEVKLSKKKKKERDKLSVAELKALVKKPELVEWTDTSASDPRLLVHIKSYRNVVPVPAHWALKREYLSSKRGVEKPPFSLPKFIKETGIAEMRDAVLEKQNEATLKQKQRERVQPKMGKLDIDYQKLYEAFFRFQTKPELTRYGEVYYEGKEYETNLRHLRPGELSDELKEALNIPPGAPPPWLINQQRFGPPPSYPSLKIPGLNAPPPPGGAWGFHPGGYGKPPVDEFNRPLYGGDIFGVLQPQVNTQPGEPIERKLWGELQAPEEESEEEDSDEEEEEVEENEVGIGIQTPSGLETPGGLVSAVPSEYPGDMSVGGNFDLRKQKRGTETEESSRPRSAYTVVPERQIRAEGFFGGERAYDVRAATEKANLPILGQDDDNSKRRKPGDVDVSLDPDSLQANDGISKEEVRRRYEAQKREEKRSWAFDEDLSDMIAQESRKRQKRDEDKRIEKKEKSYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYL6</accession>
    <name>A0A0B1NYL6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003284">
        <property type="protein sequence ID" value="KHJ31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYL6"/>
    <dbReference type="STRING" id="52586.A0A0B1NYL6"/>
    <dbReference type="HOGENOM" id="CLU_422845_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="648" mass="74153" checksum="57F12BC67553501D" modified="2015-03-04" version="1">MSRVQRTFKLLPQAEKAEPLFPISSTSHSMTKKEGIETHERWENSVHPSEICAYSDGSSEGHGRSSWGIALQRNGTTVGIFKSRGNTNANTRSALLRTDQEISKYLELELLEKKKSKQFTMSKYKGKMAPAIDLKAICGLKDKTNEEDDDNLSSISHSVIRDIDPFEADSDGLQALVEIRLEDYKEARLQDHALWDTFKNDFEAWTKEMWDKLGQCSLKTDMRNFVIANGISLLIHYGGKAKVTISGSLVDLAHKDEWPPITQKLIDWGTMQGYDMDSPAIRRIENGDSAEFSKEELLKIRDQRRSIKAAKSQLTKSLHIQMHGNHEQHTNETSIHRGEDSLTTRDFAKAAANVERSDKQENKYEGTGDNFAFKIMIFKDLCRRMDLPPSQYMRAFPAMLNSIALSHYHFSNLADMNFEDAVHIIRTLCEGEDYSDLAQSKWNEVSLASIIEENQSKSVTECFKLLNTTLGELRTELPPELQTVAYTRSRIMLACTGVEDYRATFTNPPKDLGNLISSFANSIRAKEAVEKIEKTPSTFWTDRKFHRNYNNQSSPSHDNILHRPKCYVCGKEECRSWKHNSEREKEAARNRHASNRRFLKLDKSSPRFKKRFSQWLCQYEGDADEDDYENAFAINTFPDEAIVNSNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ01</accession>
    <name>A0A0B1NZ01_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01003122">
        <property type="protein sequence ID" value="KHJ31208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ01"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ01"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="OMA" id="ACIKKAC"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000692">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="59689" checksum="0177B316CB31F8AA" modified="2015-03-04" version="1">MSQLAPLPQDLPFRIISKTIGRGAYASIKKAIPINNTSPVFVVKFIHKAYAIKHGRLSAKQIAMEVSLHSHIGKHSNIIEWFATGEDSVWKWIAMEYAEGGDLFDKIEADVGVSEDIAHFYFTQLISGVNYMHSKGVGHRDIKPENILLSGSGNLKIADFGLATLFEYNGKTKLSTTMCGSPPYIAPEVISCSRNSRSNGSSTTSGYMANLVDIWSCGVVLFVLLVGNTPWDEPTSNSWEFQEYVGKKGRSSDDLWQKLPSSVLSLLRGMMNVDVTKRFTFNYIKQHPWYTRRNKLMTVDGMMSDPLGLATQMLEELHIDFTRVPTASQSLRQSIDGFSEKKLNQKLPQFSHTQPELPAYDLDFDWDRPARTSVQNFSASQPTNFHTFDYFVEEPGMKQFSPISSVPLSLTQNARHFKDIIPAQSLTKFLSHLSISLLLEFLCSALHSLNVPTAPITPFNLNQEPWIKIKTLDGRRCTLNGDIIIESYGSNGDRELLEVRFVKIKGDPLEWRRFFKSVVVLCKDAVFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZF9</accession>
    <name>A0A0B1NZF9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004288">
        <property type="protein sequence ID" value="KHJ30420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZF9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZF9"/>
    <dbReference type="HOGENOM" id="CLU_061015_1_0_1"/>
    <dbReference type="OMA" id="HITIHTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="245"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="39599" checksum="22DE39DABAD5CDDC" modified="2015-03-04" version="1">MIKWRLQKLNICVLQPILKPQTWRSCRFLSQKSVEIIENLKDIESHSSLSTTLSAEDEKIQAYDPVSRSSRRLRQLPPSRYQFRSPRYYRGPLHPHQPPAKTDPASREFVPGPFSYSRLEQTYESTVAADLLTMMYVHRQPGLVTTPRPDRLRMWDDSSPYHKGRPKRGPRGPGDVLRLIERDIHWKNIPRITEITVHSFVKNAVDNTAYLHVAGMLLQAVTGVRAQVHNAKKSVSAWKLREGTPIAVSATLRDSMAYEFLDKCVNLIFPKLKDWPGIKEKTGDKSGNLAWGFSPDGVILFPEVQVNYDMYPPKMIPGFHVIVKTSATSDRQARLLLAGLGVPFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZL6</accession>
    <name>A0A0B1NZL6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005070">
        <property type="protein sequence ID" value="KHJ30121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZL6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZL6"/>
    <dbReference type="HOGENOM" id="CLU_003431_1_0_1"/>
    <dbReference type="OMA" id="VFEVPNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="936" mass="105757" checksum="FF4619194A146A8E" modified="2015-03-04" version="1">MPSFSLFKNRSEEVHGVEIDWHYSDVESEKYGKISPRLFRRKYIRKLLKKQSLSSVSDKSTKQQNDVFYKSSLLLASKDEKTNDITLASLYKPLPPTPFQDSSAESLIRPPIKSNRIITPLTLTDLQELFSGAPHFHVKSEQDIDRAGPPKPYVSFPWDPCFQTKDLRDHAKIDDPAWACITANKFCLGYAATNIKAAKEQKNQSKTGFNSNCREIPNMLSMQGLERGTIGYQAALELTVSDRLATPDYTPLEVLSSFRVSFLQRKEKLRTITDSVLLNRLIAIGEIYELEPLQYHKSPFQLYTEVFTKILFPSPQILDIEDPYSLQVQIYHLIEILKTPKIWFDFSQVKWRTQLGRILWGPDNSRRDPTSNFLDAAAETQKFCSQKYWLLLQILLGCEIILRLDILSTKIKPDDSVLEESNFFGQKRTQSINWTLLLARTWLENIRLEVVDYNKKGTVLVDSKECSSGSSNLLSTLKLHGRNKSRQISGMLHFAEALKWPNIKTLEETIRNSPQSYSDEAIVMKSMRGLSRSTSCREITKFGKLDRKHDDNMIHTNKWLTDSYMSGLILPGDGLGLLLISSLLENDPRAIIKLGHRINPRGAFVYGGRSFWSTSNIVGKVIASRKNSSECIGWVSSDVLPRGFKEGWIDIEAYSSQESCKDKKSKKARIWHKKTVERYSSVIAGADSSSILKGDFVLPSEKPFHTPLTVKFLSLDIFALEDRMRPVYGTDSFVESLADEDENGVFPLFSSTMRFLVGCTSDFQTELSIDLAYNINFVTAHPCIPPSNTEALLNSVNSSYNSLPPMSPITMQGSGHPLHKAFTYTKLPLSHVLSIPLRTSFATLLTPPTSPTLSQSSLHTTSSNIPKILVIDCTDQDSEDAIDIFRNENSYDKELLARAICAERGWNAVISRKNRCCLACSIREASALGVLVIIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZP0</accession>
    <name>A0A0B1NZP0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cytochrome b-245 heavy chain subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002569">
        <property type="protein sequence ID" value="KHJ31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZP0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZP0"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="OMA" id="DENQAIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="276"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="581" mass="66411" checksum="F6DF706C464558F8" modified="2015-03-04" version="1">MSASIRQSVASVSSVKSERSRWPPLTRMLMSGELSNNAPKELSNRERFDRWMVNEGYRRFFVFVFAAIHAMVFTFGFMNYQIKDNLTKARSTFGLTYPTARAAALTLHFDVAMILFPVCRTLISLARQTPLNGIIQFDKNITFHKLTAWSIVFFSWVHTIAHWNNFAQISAKNNLGFAGWLLANFVTGPGWTGYVMLTALMLMVVTSVEKARRANFERFWYTHHMFIVFFFFWSIHGAFCMIQPDFAPYCIGIGSSAIGVFWQYWTYGGYIYLFERIARELRGKDTTYISKVVHHPSNVCEIQIKKENTKTKAGQYIFFCCPEVSVWQYHPFTLTSAPEEDYISIHIRMVGDFTKAVGRALGCQLDKSDKSSQVLSEGQGNDAGINRVLPRVYIDGPFGSASEDVFKYEIALLVGAGIGVTPFASILKSIWYRMNYPQKKTCLRKVYFFWVCRDFGSFEWFRSLLLAIEAQDKENIIEIHTYLTARIKADDATNIMINDANADRDAITGLRAPTNFGRPNWDMVFKSICKIHTPAEAGVFFCGPKVLGSVLHIKCNMYTEPGTNPLSRFSKNFIHSVRLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZR8</accession>
    <name>A0A0B1NZR8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004932">
        <property type="protein sequence ID" value="KHJ30161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZR8"/>
    <dbReference type="HOGENOM" id="CLU_1284121_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24401" checksum="FCCEA431CC4CF296" modified="2015-03-04" version="1">MTEKSRIRMPKLNLSLFDGDGQSADRWLALLKQDFSAENVYKETHPQLWLEAIYSKVSGKAEDWMDQTLQVRKIMENRETATILEVEAFEIEFKSRFPGRTAARPQSSPFLYAQSLKQEPHENLVSYIARVRDLWNLAGGRNPTRMEPMYDMGCQVIVQGFVSGLFEEVVKFKAIENGAMGVTDLEEAISKVNAAVQTFGRDEPAASRILTSVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS3</accession>
    <name>A0A0B1NZS3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002862">
        <property type="protein sequence ID" value="KHJ31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS3"/>
    <dbReference type="HOGENOM" id="CLU_453564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="602" mass="70753" checksum="899F9AD4B96F5EF5" modified="2015-03-04" version="1">MKAYLIAMAHINIWDLPSSSKNPPRFKEGENYLLQQPYSSNPSIKFLKKNYEKDYKAKSKAHSHLPSVAESTKTKIHVELENTRPRTIPYSTIEKGKHRATGNIGTIVEDSLLDTRDYQTDKITWDLPSISRDPNAESRREVFRKKLAKAAFAESIALGENKKNGDLFVQEILIKTWAIDPPTSARSSGTLDLDAGIWRDFAYRDPWPELPGTTPLLSPDGFGKFFPESWNSSQESSLSSPVLNIGKEEINPQLKCGELKRGNEIFSDPRTENKVDRWLQSYSKNISESNQQHADRAQKLLLKQIFQDSEEVKLLRDILGLVDFERILRKSELRHNSAKNFIKFYRKNAEIVLSRFSNRIKYKENFIPSLNELQSFKRWRVECAPWRAHYNIKDILDLQPLQRDINTLARSYFNIQVQEDPETRFMPIYRAFYQLELYCQLFRISKFATPETSGDRLEKMKRCFFERYMPYETSQIFKISRWFLREWFVIDKLCDSNVRDKVRKKLSGERYNAYHRNLGIKFFAELLYSDSEKQTALMDKNRWQLNMIKFAWRTTCWAAQDEDEKGNVILIEDQELIEQNNDVETRKRLFGSAFSPWSRLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZU4</accession>
    <name>A0A0B1NZU4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005131">
        <property type="protein sequence ID" value="KHJ30104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZU4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZU4"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="238" mass="26144" checksum="6E67D48DD058E4B5" modified="2015-03-04" version="1">MLNAGNRLFLTGAKLEPSANWIPMIIPTVPSTIRKVQGQIEVSNSMLTDEVERVCTIRPAHVKLYGGNKAEAPHKTWMAYFSKAPRAGFRVFDESGIARPYKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHTEDLCMASTKCRNCGGPHRSDSLRCLARPTRSGAPTKEQMRTFRQIGEREYQAVLRAKAAEESAVFAENNIMDLTSSQDSEVGGDTDNILASPVENSKDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV7</accession>
    <name>A0A0B1NZV7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002491">
        <property type="protein sequence ID" value="KHJ31897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV7"/>
    <dbReference type="HOGENOM" id="CLU_011453_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="515" mass="55742" checksum="8FBC3049CD778CB5" modified="2015-03-04" version="1">MAPIMRMGTFIFKWEHPAEEVYVTGSFDDWSKSERLSKTNNIFAKEVVLPIASDKIYYKFVVDGNWVTDHTAPQENDELGNLNNVLTVDKITILPPESVGIMSGVTADSTTVSMAGKVPLVTNQKYDSTTLPGTFPITPGVAEKAECEYLTKPVSIPELSNTQAAHDDHPTPFVDTSNNLRNGADEKTKNEKVFGVSPLPAFPGAVNPISIAPGEKLPDYSLLTPNTLKSNIDLKDEKHIQSNSVTDSLPTTDLASSQNERDIDKIVFSNISKPSEINDPVTILPIKLGMTDEIPNSPFIQSVGPQSTTATLASEVPIKSNLEQLSENTPESGVHKSGNEIKGSIDLNDSANTTDINSPQEIEGKLPNSLTQSSSISGNISGIEKESIIKQGQSLENLSNMEGIDPKIEVKKDHPSENTIKSSNEDLPRSPAPQALTEPAQTSQNSDTTTDANTEPKKVSSNSTSPACCVRNSSTFNEADTGNNEQTADEKTAKKKKRLSIFGKLKAKLTFKDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P038</accession>
    <name>A0A0B1P038_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tfiiic transcription initiation factor complex subunits tfc3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002417">
        <property type="protein sequence ID" value="KHJ31997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P038"/>
    <dbReference type="HOGENOM" id="CLU_235724_0_0_1"/>
    <dbReference type="OMA" id="WIAGEWW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1905" mass="217403" checksum="5FC9868C8D26477E" modified="2015-03-04" version="1">MEQFVEVVNCNNLTPRNLSGNEEGNTPVFFPNKSDMSSKKGTYTTYEQVRYEAGLTGVYINPKPRGSAEPTRGRPVKRPRFVVFRSERLRDPLWLEKRRGTWHNYVAEAITSQIIEAENITQAAQKRKAGELNKQSIEEEIEINAKKRKVIKKHDISKTKQQNMHQRLEPIPPQGNSRNNELTPSESNNLLSQNSSETSAFSVPLETSQSHCERSNLISVNLRATRTSNRGSSHNEANDCIPNKSNSSHHISPYTEIENKNRLNNQKTSLGYPSHEQYLNQWTSLDQPNYMAQNLLSKNPHQNNLILSTNVTSNTNVGTLQVETAAIQTPISGRVTRKSSSALNHEASQNLHSVSFCRGYQPVAKRFGSNISEASSLSPSEKLNYQQPKIINQNKNCHWRKSPRNIAFQESEKVGNSIDCEIPSANSSSREIMKREFLQFEQQQDLVPLEKNLKRPRSEVRKKSRTPESSSNRDPDLDLAEAINFSPELDRLTCRYKGKAGNLLLSANKQCLEFLPIDQDCTEDSLFRLEISRIQNHPITSIAGSEPMELRFKAIGQDNTVNVHIFEFSSAVKAIEAASTMRAKIVTGIVACKFRSGEDYNHLVEIQEESQKPFKCESCQKRFKNQNGLEYHVSKAATTCNPNFDPQVGPGKRGRKKRRRTPDPTSANTQPGSVISPSSKPRYIGHETSNDSIESTNESSTFSSSDDSVIKWAMQNSSKMMGKSQGKRTTKASSRSVQKNQISYKSLPREAEALSKIVEESTSITSEVKLSFPQVEFANVIPNVADQAPLSGTLDMARYESILLSLIRENNGVFPGDKSLWFACFGAWLKLKLVIPTVFGETIAPESKFCSQLIDDLVESRKLRRHDLKFQDKNGRQASRYFLSFPGTKLNWSLIRETQKLIKKTYPDFYVPPQFSPPESVLSKLRDLTYQSISRPTICDKSEENIYSNSRQSSVSSKPDDLNSNQNKVFNNENPEKPKSKINNMSRSSPVISKLDNENRIKSRNLKISEGLRRYHQSLAKNPKTCRAAERDKSHRKTKTPGNLDNVSNQSDNCPVSTLPDLGRRARSQTHSKFTKSSRTSLKYDRTLPDFVVYLQDPNSSWSIEFCTPNMISIYLQSLQVDEPSHLESPNLSAEGMYNLSEKSLKPKVPDRESRKSRTTDKAKLRLTEMHLQSDVYTNEDMEIIKPSRSGNTLGLEHDNENITQKDTESESESDSDYTIPSIQKNNSNKATKNLCEMDILTLYEPKKLGSKAARNPGLETLPSNFSQPTISCDLIEPLLDFSGGQVMTKVISPQIVDSQCNFDKGSWTVVEFFEYREEKYNPRFDERTAFDIETLPYRDLCFALSIEETVPITSYARIQEEAKIARRKQSNSCRRLKFTRLLTHLNIDFWGIGCRPEISSKYLGIPMTAGDEIAKLRKRNSHDSMSLMVEKRFIVAVIVIRTLTGGIECLTDWVLVSLLFPRFSLNFIRGHWKQLVIRHKKAIDRLEIDFQNAFVPAYESGKIQTLDYDNLQDYNWNKLVDWTMNTIDTSFSHKPVSIPRSRDELKNQYALEISDSKDSWRDKCFETNVAIYKRLDYACFNSLVMPVKDLSKTKNECESTELIFARSWIRALALSPEVKSLNKTSQKFSKKIGEKALSELIESKVIMYRSKKRVNLSYCDYEATEMFSRPLRREVKPKCFRDASVFKRYLDSEFRKGKSHVRIDYMAWDGDVMVISNLQAHNRIQLQAIDVPREKFGLTEGGYETKKIPRERLRFEMDIYPTSTYTYDDENLVVLKALNAGPPRGNQIAIPVWYNTSETVISSIWKDVFSAVAQVIALRAGVNIPELTRIFTPTMEEWEIRLLLAWGEEIGLFCRLHEKIDGWIAGEWWWAYAMSLFSKDRFTAGQDVRYEPKDPFTMEGRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E0</accession>
    <name>A0A0B1P0E0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative myg1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004432">
        <property type="protein sequence ID" value="KHJ30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0E0"/>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="40429" checksum="2C1A30E6AB878D54" modified="2015-03-04" version="1">MLRNIVQMAEATTKKIKTLPVTIGTHNGCFHADEALAVYMLRLLPFYNNSQLIRTRDSTLLSTCHTVVDVGGEYCPEKNRFDHHQRGFNITFPNRSTKLSSAGLVFLHFGKAIIAQHIGVSESAEDVQIIWEKIYTSFVEALDAHDNGISVYDAKEIAAAGLEKKFSDSGFTLGAMVARLNPNWNDPIPSDPERAQQIEDEKFLTASSRMGEEFYRTLDYFSKSWIPARQVVHKAFSKRLEYDTKGRILVLEGQSVPWKDHLYDLEMQEGIESRILYVLYPERPTVDSKWKIQCVPESKDSFQSRKPLPEAWRGYRDEKLDEVSGIPNGVFVHAAGFIGGNKTYKGVMDMAIKALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0G1</accession>
    <name>A0A0B1P0G1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01004353">
        <property type="protein sequence ID" value="KHJ30386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0G1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0G1"/>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="OMA" id="RLPNVEC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="218"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="43354" checksum="FA3E5A4036A81865" modified="2015-03-04" version="1">MSDASDHVDSEDEALQLPSFYSPRPGPASRANSEVEINIGNLRNRRTPSLFDPDTTSDNPLSDPELDLRSNNFLKQTTTSSSHKNLVTSSTEYAIPKSILVNSTEVNGGCGQKRPKLLPKLPDVKCVVRARIPTTLGSSGTDMFLHLYQNSEDSKEHLAIVFGNSIRSRSLDRVREGETEMDRLIRGAYVGRLYPGRTRSDLPGEVKDLDEHQEKMESPLVRIHSECYTGETVWSARCDCGEQLDEAARLMSVPTHDNPHPSGVIIYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADSRSYGLATAMLLDLGITQVRLLTNNPEKIRAIEGPNREIVVNERVPMIPLAWRKGEAGGIRSQEVGGYLQTKIKKMGHMLSLEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L6</accession>
    <name>A0A0B1P0L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003603">
        <property type="protein sequence ID" value="KHJ30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L6"/>
    <dbReference type="HOGENOM" id="CLU_1579671_0_0_1"/>
    <dbReference type="OMA" id="MNQRYAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="15756" checksum="A044994B3563770F" modified="2015-03-04" version="1">MPLKNRRAKYLCQGSLILIATLISVAAIAVFAVATAANLIAVASVATTIAAVAAVVTVSNLIAVATTIAAAVAATVAVAATVAVAATVAVAAAPNLIAVAVTAAVAAANLIAVAVAVAAAAAILIAVATTIAAAVAILIAVATTIAAAVASLIAVAVAVNVSRACGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0M0</accession>
    <name>A0A0B1P0M0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cop9 signalosome subunit 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003596">
        <property type="protein sequence ID" value="KHJ30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0M0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0M0"/>
    <dbReference type="HOGENOM" id="CLU_022348_1_1_1"/>
    <dbReference type="OMA" id="RGIDEQW"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="217"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="441" mass="50182" checksum="64CB9C3278B747B0" modified="2015-03-04" version="1">MAAAPYTYNEKSPALKQPRFDLESIISNYKGRTIFQRLLLIGVNSTVIGVGALKAAINDAKNNKDIQRYLGAQSVLETVAPHEPEAKKDTEWITYMEKKVQVETQRLETELKQYKNNLIKESIRIGNEDLGKHYQAIGDLNKAYDAFSRMRQEANLPKHILDVSCHLIEVSLEQKNWISVISNIQKIKQVVSTSDEDRALQPLLCAVEGIANLDAGKFLNAATCFLNAESGMGQKFNTILIANDIAIYGGLCALATLERKELETKVLRNSNFRTYLELEPHIRRAITYFINGRYSDCLNILQTYHTDYYLDIYLHNHIDEIYYLIRKKSIVHYLIPFSCVSVDSLAKVFVSPGQDIEKELISMIKSEDINARIDTQNRLLISIPSLPRQSLQKYTLEMAKSYENEALLRLQHINICSAELEVKCPSPDTTMMDDGFDDNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S2</accession>
    <name>A0A0B1P0S2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002570">
        <property type="protein sequence ID" value="KHJ31803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S2"/>
    <dbReference type="HOGENOM" id="CLU_027095_1_0_1"/>
    <dbReference type="OMA" id="FPHKQSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="418"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="589" mass="67126" checksum="3858EE9095150E02" modified="2015-03-04" version="1">MSESTLLPRSSASKSSTNHVRLPNGQSLTVRPVFGGFLFKPDELNVQNSTFPAAWTVILQTEDIIQEDGFSSDHVDQKPDEILEKKARYTHPYRRPTLQSDSLFISSISNPSSHDFSTQNSSSRQIVMMLWTSLYWYFHQEEPSPFLLCNTSKITSETEKIRGDWRINIKPEGILRGRHLIQKLERMGLVTSKDSSVGLEPPEKMVKCWSNTFTSRRAFWQIPAKYFLKYTTNSPGLLLSSTPYASRPNSPVFGEPKTTSPISLEFVDSHSRHSSQGLTSQFSIGSLSSESQYFIYYPPVPLQYTTSSGIQHPLRSKPPGQGEIFYTRFIPSFGQFLSFRTASLSEKPVPYKGPTSDPKSLSHHSKNSLPSATLPVVLSPTIQTPSSIHSNFSLSPFPSPVPLHLVDDGLPSNLLKLMCTSRMTDCQLLHRWMNIPRVSKFWGCDGPILHQEEFLQKNLEAQHSFPVIGLWDGKPFGYFEIYWAKEDILGRHINDGSIGDWDRGIHVLVGEDEFRGKHRVKCWLTALAHWVFSEDYRTNSLVLEPRVDNEKFISYLQESGFLKEREVSFPHKKSKLMRLRRDQFEAPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0X8</accession>
    <name>A0A0B1P0X8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2112</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002513">
        <property type="protein sequence ID" value="KHJ31878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0X8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0X8"/>
    <dbReference type="HOGENOM" id="CLU_102602_3_2_1"/>
    <dbReference type="OMA" id="KEFTMQD"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14408" checksum="480005DF76F6649F" modified="2015-03-04" version="1">MSKEFLYSEVSEHSAKEDLYMVIEDKVYDVTKFLDEHPGGEEVMLDVAGQDATEAFNDVGHSDEARKILTNLEIGELKESEKDSRPKPVPVSQSISLSSSSDGGIGLYAIIFLGGLAAFGAYKYLQKQEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z9</accession>
    <name>A0A0B1P0Z9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004105">
        <property type="protein sequence ID" value="KHJ30504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Z9"/>
    <dbReference type="HOGENOM" id="CLU_772066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42543" checksum="42113D9E359A1D8F" modified="2015-03-04" version="1">MTENYSDYTLCGRFDGQKVTPSRWLTRLNMDLEKASLKKPEDFFEAIDILFEDKAANWLDTSPRWRKVVDNKENATESDVIDFKKAICTHFKSNQEQTDPNIHSDWRNRAQGPNEPLKKYYQRYLDILSRSHCRDEPLAESGDECLKPLEVVFSSGVITALIEEIHNPELRPNVLFKANNTYYSLYGAYEALKGIQNSMIKFREIETRLAKKNELEQFREMYSQGRPVSATVARLGQQNYVEPERQYSLRNDLPSSHLYHGPINTYDGNPRYQTSNNYSNMQLMNQSPENKRPENQGYSQNPWHNGPKNYRGIDTKLLPPKNLSKNPYVNGSRSWNQSLKPLCIRYGTVGHANPKCGSHTSSLLENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P134</accession>
    <name>A0A0B1P134_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003354">
        <property type="protein sequence ID" value="KHJ31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P134"/>
    <dbReference type="SMR" id="A0A0B1P134"/>
    <dbReference type="HOGENOM" id="CLU_1732842_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061714" evidence="1">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="148" mass="16732" checksum="5C17B24EB7EA702D" modified="2015-03-04" version="1">MPMQVSKIIATLILLSLGFCSAMYANRPYSRGVRIRNANCNGRIHTSLKLAQTVDRGVELMNELTQSGRSIEFLIYHPQNGGILNTGETYYFFQINTENPDDPARDFVVITRAGVLLKVVTQMQIAEDSWMFVNCLSNEERILETGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H5</accession>
    <name>A0A0B1P1H5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative lag1 ceramide synthase membrane component lac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002050">
        <property type="protein sequence ID" value="KHJ32482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1H5"/>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="OMA" id="LCRLCML"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="186"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="469" mass="54824" checksum="15570725BF578DBD" modified="2015-03-04" version="1">MTATEAFPSFSTNSVNHSSLEAASIHIQPRIRRTSSRLGGEIRAGDTSAPALATLDIRQPSLSAVKAQYELDKRKPFSKRRKAKTLLQQWKRYALRHTWVTPLVLIAVFLSLYVFNPTTSNPIHHFLFLSYKLPLEPGQRRPVYAKGLWDIAFVFFHVIILSFTREFIMQKFLRPLSRRCGLRSRAKQSRFMEQMYTAIYFGIVGPWGLYVMSRTPVWYFNAQGMFEGFPHKTHDANFKFYYLFQAAYWAQQAIVLILGMEKPRKDFKELVGHHIVSLALIGLSYRFHFAYMGLGVFITHDISDFFLATSKTLNYLNHPLVGPYFGFFILTWIYLRHYLNLRILWSEFNEFQTVGPYVLDWKSGQFKCPLAHYISTALLTSLQSLNLFWLYHIIRIGYRFVFENVAEDDRSENDEKESVDKNTPEKIKLKDDVKKIFSRPLFNGKARKDEYSVIQRRVSSIDNNHTHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P0</accession>
    <name>A0A0B1P1P0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002283">
        <property type="protein sequence ID" value="KHJ32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1P0"/>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="382" mass="42899" checksum="EB41733EC9FABF4F" modified="2015-03-04" version="1">MRLIKQDIEHDGSGTATLFPEEPEDMWHAYNLIAAGDHLRASAIRRVTTESTTGSTSSHRVHTNLNIIVKLLDFDPQAGQLHVSGQVAEENKWVRVGAFHTLDLELHRNFTIEKKDGWDSVALDALREAIKEEKEGTIPAIVMQEGIANICLITEYQTILKKRIEVSVPKKRAGKSVDHEKGIIKFYDICLETLKRHFDLAQPRPVLIASPGFIAAGFQKYIFDEAMRTGNRPLLDNKKNFVIIHCSSGHLHSLNEVLKSVQVLEKLKNTKYAKETQLMDELMKCLRKDDGRAWYGSNEVEKAVMQGAVGRGGGTLLINHCLFRSQEIGIRKRWVALVDKVKEDGGDVRILSSDHESGKRLEGLGNIAAILTYPLYDLDNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q2</accession>
    <name>A0A0B1P1Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tyrosine phosphatase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003614">
        <property type="protein sequence ID" value="KHJ30791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q2"/>
    <dbReference type="HOGENOM" id="CLU_049223_1_0_1"/>
    <dbReference type="OMA" id="KGTGWRY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="459" mass="53230" checksum="5D9D7277741AC8D6" modified="2015-03-04" version="1">MSVPPLWVSRPSIITSSKIIMLPQNNSRFFSTNMQLNRQVRMRREMFKWINRVGKNLKDPLHNSTNYLSAYSVSGNLRGVEERTVEHLRKVEEIKTLIKERPDIKEEKQIELNRLEEQYSLESKILPAPTRRDMMPFPANKDFISEPVLGPWLQNEIWADVMNRGLTVREVSSLRGVEMGRVAAVVRLLEVEKSWKEKGKEIADSYAETLVDMLPYTGKTALLNWSDEDEQALNDAKLDAKMKAQREVKEREDENIKRKTASLPPLPPAQPKIPDEIDLKRNIIENRRRSPHESINDLPVLKITGAQLWLPVSESRRFTRADAAKAFDSNLQPADKRVPHPELTQMHKEYLAGKTLEERAILQDQRAELERRKILQRRANEMKRENSIKKVTNKRGIIFRFHEINVNSIEKDGRGTKGVGCRYGVPSMDRSKGDVKIPQHALVPPRHMPVYKYRNFQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S5</accession>
    <name>A0A0B1P1S5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003091">
        <property type="protein sequence ID" value="KHJ31240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S5"/>
    <dbReference type="HOGENOM" id="CLU_659213_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012678097" evidence="1">
        <location>
            <begin position="16"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="417" mass="46474" checksum="30BF311CE45D5DC4" modified="2015-03-04" version="1">MLFFILEVYSKITWAVVATIVRPHYGIHSEPAKSKISPARRAGVNTQYTLHVWDGQQDSHNPSLQDSHSSPRVSIVFVSTSLSPSPQHLFNEAPHDWPGEYKVKGSILSQRISDKFLENPRSANRNNRSPKAHARGFRCYTCKSEDHYSEEHNSETSTEHEDGGIIEVGLMVLEKKISLDEHTTLETLYARRVVLSKSGMEGVALLKDCLFVPGLGANLMSLRKACAHAGLKGHFEPPLMKIKSSPQPMKSIDGSHGVIKKIRTSNSTRSIPSTNNLKRNFKPIKSKLNNRIVVDAVNETISQKVTPTENGDNHLPSNNKLLRFSDHVGDNIGYAEKFDDGDESDEKTAFFAEELMDAASHSIDTTTNCDIPPPQSYQQAISDPEYGYLWLKAIDDELLSLTSIGSWREEIAPPKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Z3</accession>
    <name>A0A0B1P1Z3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003011">
        <property type="protein sequence ID" value="KHJ31300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Z3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Z3"/>
    <dbReference type="HOGENOM" id="CLU_101052_0_1_1"/>
    <dbReference type="OMA" id="GGDWSYN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="170" mass="18762" checksum="EF87894F1F50A883" modified="2015-03-04" version="1">MPLKMLHCSVSHSLKISNRYLSTTSSLKQITKTVFGNSPAPPRLPPKEQEEYERLQRLSTGSFSTPKISNSITDEVHINQESSSSSTSTSTSTSTSTTTTVRPHLERANVEVKSDGQELHPDIRRGAKPEFEGDRNPVTGEIGGPKTEPVRWGSDGERGDWSYNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P221</accession>
    <name>A0A0B1P221_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001860">
        <property type="protein sequence ID" value="KHJ32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P221"/>
    <dbReference type="HOGENOM" id="CLU_608586_0_0_1"/>
    <dbReference type="OMA" id="EHNTRIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="450" mass="50508" checksum="209CD00983880078" modified="2015-03-04" version="1">MTDKDADTNAGIALVKFSKILKGQDLPYRGYKRLLEEALHIIKELRKSKAKPLPSPKNNPKVENPTMAKILQEIQMLKSTITQSQTRPRALGQTWANVARRTEMTSTTIRITDEEEKRKIAQLSSEELVKKIGVKEVIGARQMTNGQVKVFFAGEETRQMMEKHKDWTQKLSSTAQIATPNYQVLVHDMSLSFDPENPEQIKELQNTNLLYIQGITIRKAAWLKKIRQPGQKTSSLIVWFDRAEQADIAIKKGIVWKFELKATEIFRSGFRLTQCFNCQKYGHVAKVCSAAPKCGSCAGEHNTRICPGKQDVRCINCARKHKAWDQICPVRIAAKAKTVMNRTQDSGRHTAPENQMSDPEGDWQIVGSRKRRAGMAGAQVVGIDGEVIARRGPGRPRKTPAPGIPATVLFEPNLATTANMLTQLTQNESRAVTRDIQAELNRAPECEKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P227</accession>
    <name>A0A0B1P227_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002208">
        <property type="protein sequence ID" value="KHJ32283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P227"/>
    <dbReference type="STRING" id="52586.A0A0B1P227"/>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="352" mass="37750" checksum="58931ED33A61A3DD" modified="2015-03-04" version="1">MEIPSSSPLTGQSQVLATALHIRSLLPDWYTPTVAIIGGSGLSALEGTISSLDPPPGKDLASEQKRRLEVKFNELVGFPIPSVSGHVGKLIFGTIATRNGIKIHAVLMSGRAHFYEGNDAKTTTFPVRVFGALNIKVLIVTNAAGGLNRNYRVGDIMVINDHISLPSLSGSFNPLIGPLDESSGTPGNRFLALSDAYDYNLRKAAWQAWKKMSSLRIEEGSCSQTPGVDRARKLQEGIYAMVAGPTYETRTETRFLSAIGADVVGMSTVPEVIVARHIGIRVLGLTLVTNLAVLEMAPRGDAELEGCQNQNYDISAGKANHKEVLEAGKVAADVMRDLIIEILGTDEVLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G6</accession>
    <name>A0A0B1P2G6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003563">
        <property type="protein sequence ID" value="KHJ30819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G6"/>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="OMA" id="HEDQRMK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="251" mass="29293" checksum="4813851D6B159498" modified="2015-03-04" version="1">MSSLKIHPSLNSSNELSLIDSLPGINFEFDELRNRMAKFTIKFNNFIEQGRRQILDERNQFRLTIAELKEDQRMKKRDIEILAQKSNTHEKIMAKEAAETEEMKSAISSLTAQRDAQLATKETLLHQITEVQKQVDDKLAAQRAHARHLDEQARFNLPELDIWTSNLCLEIDGANQNDRLNFTFTHVDDQDWTREASFELDFSKRDYIITCCKPNLKKIDVDKVLDKLNECRDLRVLLKGMRELFVEALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2P5</accession>
    <name>A0A0B1P2P5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclin-dependent protein kinase complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2P5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2P5"/>
    <dbReference type="HOGENOM" id="CLU_013692_2_0_1"/>
    <dbReference type="OMA" id="SRFHPHT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="472" mass="52848" checksum="CBF59129627CE488" modified="2015-03-04" version="1">MAALISDFISDSGHFQHNHKMISGSSKQLSPAEAQYLKISSLRDIHNSPHNQPISLPNEQQLSNTDSTKLLAHSGNTDDKALPVKIGVVSPPSSSKIPQTRHKFISQENILRPSLQSARSPQNSSQDLKKRKSSYSSTNSTYSASLRSSASFCDVKVSSVDKIKVQSLAHIQKFAFDDSVFLGEHHGNQLKEYNSSLAYEISSMPITDVIEMVAGLLTKIVTTNDRQHSTRSKLPQSSDSYSYISDNTSKISAFHGKNVPNISILSYLSRIHKYCPTTYEVFLSLLIYFDRMTEKFNKVPIKTEERQITDSAGSISSSEDGSYGAEPSRTPQISSKDHKDTYNNSRDVQNTSDDSNNIYSHEITSSRLFVVDSYNIHRLVIAAVTCASKFFSDIFYTNSRYAKVGGLPLLELNHLELQFLLLNDFRLFVPVEEFEVYGTMLVEFYAREVINQKQQTASVEIKYPKESSSPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3G9</accession>
    <name>A0A0B1P3G9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative upf0658 golgi apparatus membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003114">
        <property type="protein sequence ID" value="KHJ31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3G9"/>
    <dbReference type="STRING" id="52586.A0A0B1P3G9"/>
    <dbReference type="HOGENOM" id="CLU_029564_0_0_1"/>
    <dbReference type="OMA" id="FWTRREN"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="387" mass="44132" checksum="334F1F307EA8919D" modified="2015-03-04" version="1">MAFGHDSRSSLVRIRDDFDSDQPYGGYNSRQGLTPRVKNITFRGGRMYRPSTPWAWAFMITTIIQALNVLAIELYLFVKFQASLKPDLEPTPLSKSIPTYLTLFIFGFLYQLLLVYDSLRLKNTIQVIGLCIYNLGMLIYASIQYDQIKRALTGLSAVNYIHPSNTVWNDIRPFLLAVPCIIGTFTLAMSLIAWKLYDEFAWTIYKHISADLRMKRRFLTFQIYIALLKFDFFFFLGFTVQFVVIVTGLADTEYALTIAAIPVTVLILTMAGFWTRRENKVGMILTIFVYFCGLGYFTFKLARMYQAKHEANYMPIRKSLTSFAVLTIILIILTIINASACTANFGMGLKPHIMKRTIGGEEAAEKDIMTELPDLKHGPVSSRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3H6</accession>
    <name>A0A0B1P3H6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sphinganine hydroxylase sur2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002512">
        <property type="protein sequence ID" value="KHJ31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3H6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3H6"/>
    <dbReference type="HOGENOM" id="CLU_043293_0_1_1"/>
    <dbReference type="OMA" id="FFIFWDR"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="42949" checksum="3F7368F445DF4344" modified="2015-03-04" version="1">MANYTVVGVASNYSSMSDLPPLPSYTLSQVKPFISFIPDFYLTALIPIAVYWIFSMFFHLIDTYDIWPQYRLHTPEEISSRNRVSRYEVARDVLIQQFIQAIVAIMLGIMDPEQTIGREQYDIACWATRVRLAQRALPRLLALSGLNAVTISRSISNSHPILAGLLAGGKYPSLSMQMDVASGSMVPTFAFWEILVAKAMYWLIVPACQFILAILVVDTWQYFLHRAMHLNKWLYTNFHSRHHRLYVPYAYGALYNHPVEGFVLDTLGAGIAYKLAGMTARQGMLFFTLSTIKTVDDHCGYALPWDPLQHITKNNASYHDIHHQNWGIKTNFSQPFLTFWDGFLGTMWTGNTSSKYKRRSKVTNHRLQLEKSNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P408</accession>
    <name>A0A0B1P408_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative coiled-coil domain-containing protein 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002946">
        <property type="protein sequence ID" value="KHJ31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P408"/>
    <dbReference type="STRING" id="52586.A0A0B1P408"/>
    <dbReference type="HOGENOM" id="CLU_042321_0_0_1"/>
    <dbReference type="OMA" id="MSKPLAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="5">
        <location>
            <begin position="103"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45663" checksum="5764A5FEF563F007" modified="2015-03-04" version="1">MDRNKLKYGLNIKKKNPNPQSKSGRRNIIFEEEENLDDTTSADVEEENICEIGGLDDNKDLIDGSFPKKISHSKKDKVPASGVSQKKFSLTNEENLSASFTSKKHENFARNLDANIYEYDAVYDSLKRTKRELKDDKDRKPRYMANLIAAAAVRKRDATIAEEKKLQRERDAEGDEYADKEKFVTSAYKKQQEENRRLEQEERTREELDAKNNVGTGMLNFYKNVLEKEEKKHAEIVKAVDERLKNGLVETEEIPREKTAAEIAREINAKKAGSIIVNDEGDVIDKRQLLTGGLNINSKKYNVSSKTNSHGKSSNLSQGPGRNFVGSGGGKEAMRQRQSRMIEAQLEQVSKRAFEQEEEAKLKIERASKSRKTEAEIMGAKERYLARKREAELAKKKSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P487</accession>
    <name>A0A0B1P487_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002864">
        <property type="protein sequence ID" value="KHJ31479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P487"/>
    <dbReference type="STRING" id="52586.A0A0B1P487"/>
    <dbReference type="HOGENOM" id="CLU_059988_2_0_1"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="283" mass="31353" checksum="7F00A82EA20AE9EF" modified="2015-03-04" version="1">MSSSVPEMKLDPIRVKQILLALTNVNNRIASKALNHDVRLVAVSKLKPPSDILALYQEGHRHFGENYFQELEEKAELLPKDIKWHFIGGLQSNKCRALSSKISNLFLVSSVDSTKKATQLNLGRSLLSTNVPLNVHIQVNTSSEDSKSGTIPGTETTALALHILNSCPHLHLLGLMTIGAINRSVAVTCGEASENEDFKVLKQERDRLEEILLNDPNKNDFQSRWGIECHPNLNETMSSENKIKKLELSMGMSNDFEVAIEMGSDEVRVGSTIFGQRPPRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P9</accession>
    <name>A0A0B1P4P9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative c3hc zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002695">
        <property type="protein sequence ID" value="KHJ31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P9"/>
    <dbReference type="HOGENOM" id="CLU_031412_0_0_1"/>
    <dbReference type="OMA" id="HLDYCPW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="271"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="451" mass="52174" checksum="AFE0297CC4A8E5DC" modified="2015-03-04" version="1">MNTTKRKFNALLNSIGSRPSSIGHDGMLQNESISSRKDIIAKRRRVTDTFSNLDQKENVHLNSNSSLGHKNSLDSEKAPMGSAEPTMPMYAPWDREQFLKRLKTFSSISHWTPKPAPVNEVEWAKRGWICQKFERVRCCSCDVEIVVKLNRKEIDGKEEPVYMAHVIEKALVEKYVQLIVTSHKKNCLWRKRGCDDSIFRLNLNQPSSTIKNLKIRYDELKLCSENLPYIYDLRTPEEFDLEVTLRYLLPDFFADENLDTNVALTNTEKVAFTLAVFGWQGYQHERLGTQPNSVSCHVCFRVLGLWIFKSKETSETGEKIRGATMNCLDVVGQHREYCPWRNAISQNGSLNTKLSLSELIPGWKVVLRVLKSEFSMLNQSSDAYKSLRHDILEKGEREKKDNEIRSRLKRVRSLFIHNSTRKGTKNDTNIKEKSLSKQDEHAFYKLKNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q5</accession>
    <name>A0A0B1P4Q5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002487">
        <property type="protein sequence ID" value="KHJ31911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Q5"/>
    <dbReference type="HOGENOM" id="CLU_002728_0_0_1"/>
    <dbReference type="OMA" id="ITPNAFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="636"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="824"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1107" mass="124407" checksum="409A2D1B15E75C81" modified="2015-03-04" version="1">MGNVSSRYDEASGLYLRDQNRLAISSLVITNNRRKTILHVVPNAFPATKYAGSRETLDSNLVEYVQDPEPASNSSNFILKLNNDDELNFKFSFIIRQVHAQDSSTLQDTNINGLTYISASSAKEIETLVTREFHADPNLHKNANVKLVGDFSTNNNQSVTFDWSWKWRPPKPVEDRGGGWRNTCSFVEYDQRAHRLNTLASFSFWVSNHQRCSSQVESAHGNLGLASSSNSRTSFQQNVASHRVGEAEIRKLDEPPSPNTEDCPVIEPLPQKDVVKFDFCLQRPGKDMSETEDGPLFRATMKSLEQKTGSMRQRMKKVLKRAEAAHVALTESNDAISAFMEALREASFSNANAVQPALEHYFDNIAREIQIYEKQSTINLQKIIIEPMMKVYNIDIKQAESKKRDFEEESKDYYAYVSRYLGQRQDSLKEKKRADSDSKYQIKRRNFELKRFDYSSFMQDLHGGRKEQEVLSHLTKYAEAQTKGYLATAKKIEDMIPQLDALSAKVQEADKEFQYQRTEREEKRRNLEMSNPIYTEPDILLSVGSITVPTVLATSPTSTPIPESELSRSDSTASQMKQAHSVNIINGNNYDHLRSPGSQSSYNSSAGSNSVNQNKFKGIRDLEERDRSQIAEKNGAQRKEGLLWALSRPGSHSDPRGLNKQAWHKFWTVVDAGKVSEYSNWKQRLDLHREPIDLRVASVREARNAERRFCFEVITPQYKRVYQATTEDDMNCWISAINNAIQSAVEGRDTRDIPAPISRQESHSKRRDIGSILTGKSSNSHGTHQHPANGISQSTSTSVFRRTTVGARPVYSRRDSNGFDESPDKLLQLIRDADQGNNWCADCNSGVKTEWVSINLGIILCIECSGIHRSLGTHISKVRSLTLDLQSFTTDIVELLLLVGNRLSNMVWEAKLEAGSKPSPQASRELRLRFITAKYVDRIYLQSISPKLSRYSTADETLLAGVKRNDIQQVIYALALRASPNVCDKSRGTHCVFLALAAADPASPSSTVPPAVSRPKPDKVIAFPIAEILIQNGAEIPAKLPAFPLSQSACLYIEQKCGRKSKLDDTAGSLPSPYINTGVRQQKEREIRLHKRVSAGGRLAKASIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P530</accession>
    <name>A0A0B1P530_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative r3h domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002075">
        <property type="protein sequence ID" value="KHJ32450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P530"/>
    <dbReference type="STRING" id="52586.A0A0B1P530"/>
    <dbReference type="HOGENOM" id="CLU_017788_0_0_1"/>
    <dbReference type="OMA" id="PFCRVPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="287"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="351"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="768" mass="83907" checksum="E85EFC9E430097B9" modified="2015-03-04" version="1">MSTDTSRLSFAKVAASAGKDNSVSFAMIAGSTSRNSRTDTPTSQPIPCIGLDVVNQKNGVIKSKNLLEETKSTSISSLQNKQNTFTTSEISESEIKLREAVKALTVTSCLPNLAVNGSAIPSVKIKPKTVSGFSQIFQRVNSSLELGTKLLSIEDKNLTSSTNFIMLDKDSFGPDNSTSIKAIQGNEIYSGCGLVIAGSGISLETAARADHAQCSDISIQHRNISQVQEYGIPDISINQNGLPCHRSLDERKSNLNGTSDTSEGFNLFYRQTPDEKLLEAMDSAKDRIFLLRLEQEVIEFVRSSKEPFFDLPPCNSFCRMLTHKLADYYHLTHQVDAVAGAVRIFRTPFCRLPPSLTSLSNAPTSGNTPPPTTMKIMRRCGDTGPSPSKAVSESESDGKEKGLSAKEKLSREEREAAYNKARERIFGKEEKNRDATPESEERNEISRSSSLSAKDRTVLAKKTKPPKQRRDDSESFDSRSQYAPFFPQPQVPTWIPSAQYPPIAPQFINGTNRPFQMPLSPQQYNPAIVSTGNIQSFNTTQQFSSPNSQRFQSPNVQNSSYGSPVQSPSSISQQWSQSIYPHPYHQPISMVRGPLGSIPYAFGQLPSTSNPADLKSQHPIPGSFNRHAFNPKTQSFVPGSIGMPLTPQIAHNITPQLDSPHLNSPRPSYNNFNSPQQQFGSGLGYNMARQNSNNSLPTYHVSPLVSQRPLMHQAIQPNSSQGALPGTISGAPQNRSQGIGIVHNNQVSNHLPTFGNTSTLPPKPPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P539</accession>
    <name>A0A0B1P539_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hydroxyisocaproate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001472">
        <property type="protein sequence ID" value="KHJ33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P539"/>
    <dbReference type="STRING" id="52586.A0A0B1P539"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OMA" id="HHTRAAM"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="59"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="336" mass="36802" checksum="236534F4DC8AD620" modified="2015-03-04" version="1">MCTRVILRIGDISRTQEEWVELSKLGTLQVFNGKTRQDFIESCASGEFNDVFAIHRSNASSVLTGPFDTKIISSLPRSVRFICHNGAGYDDIDVEACSARGIRVSNTPTAVNQATADMTIFLMIGALRRIHLPYLAVRAGEWRGGSTFQPGHDPDGKLLGILGMGGIGRDVAHRAKAFGLRIQYHNRSQLPPELDQGASYVSFDQLIKTSDIISLNCSLTRETEKIIGKEEFDAMKKGVVLVNTARGKLIDEAALVDALDSGKVYSAGLDVYENEPQIHKKLLSNPHVMLLPHVGTGTVETERKMELLVIKNIESAMKTGSLFTPIPEQNHLTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5C5</accession>
    <name>A0A0B1P5C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001410">
        <property type="protein sequence ID" value="KHJ33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5C5"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="235" mass="25761" checksum="377888A0388E7430" modified="2015-03-04" version="1">MENSNKFPLHEAARDGRARDVESILNENPKLANQRDDDNRLAVHWAISSNQKEIVNLLVSTEYFDPDAQDGSGWTPLMIAASLKEGEEIVDLLLGKNADINAKNFAGQTALHLIVSKKNIDLARRFLNHKPAASARLCDKRGLYPIHRAAAVGSVPLVELLIKHNSPINAADISGQTPLHHAIAEGHGDTALSLLKAGVDTKKRDSDEKLALELAPDLQIKKFIIRQAELEGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G9</accession>
    <name>A0A0B1P5G9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002491">
        <property type="protein sequence ID" value="KHJ31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G9"/>
    <dbReference type="HOGENOM" id="CLU_1230704_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="225" mass="25626" checksum="B885C1F685B4E14E" modified="2015-03-04" version="1">MPKALLYLEENKISYFAKWRYLRIGSRKKGKLVHASNDTEHGINSKSTTANFNAISIIGSESNFIEVQISTVSSTDIYQALQPKRIVSISDIEGGLPDEIKQFSNLFTDDDGNTDVLPPHRPGVDTKIVLQKDEQGRDKENPWSPLYNMSRDELLVLQKKLAKLHKERWIRASSLPGGPLVMFVKKPVGGLRFCVDYRALNPITEWDRYPLPLIREIFRMIAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T7</accession>
    <name>A0A0B1P5T7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative arrestin (Or s-antigen) n-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5T7"/>
    <dbReference type="HOGENOM" id="CLU_026015_1_0_1"/>
    <dbReference type="OMA" id="MVVAEEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="424" mass="47465" checksum="FB3260327A8E5461" modified="2015-03-04" version="1">MQDTHKWISIPSLHCSKSYSHKAHQTMILLDMEIESPPLVLYGLTTTSTGALLSGQLILEITHETTTVNSCSMSLVMDITRKRPFHSHCSNCERNRTELESWKFLNSPTKFRKGKHKLPFSWILPGNLTASSSGTLFSIEYKLHAVLALGGVEDIMFSKTLEVKRAIIPSEIPRNSIRIFPPTNLTANCGLPSILHPYGISMVSIIIDGCVRENAESKILRLWKLKRLHWYLNETQKIFSPGCGKHLAKQVNKIEGKGVSHTDVRVIGENCYRMGWKANYTKSPGRIEMEFPCAIRSGARPICDLKTQDGIEVSHSLIVQMIFVEETVSLIRSPIEATSTGSARVLRMNFNMTVTEHSGLGISWDEEQPPLYENVPASPPGYMFSFSNEENPIPNDDDIIRIDAQGTGHESSPKNSFDSHILVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P606</accession>
    <name>A0A0B1P606_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0567</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002326">
        <property type="protein sequence ID" value="KHJ32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P606"/>
    <dbReference type="STRING" id="52586.A0A0B1P606"/>
    <dbReference type="HOGENOM" id="CLU_046802_1_0_1"/>
    <dbReference type="OMA" id="WILKGSC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059378" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="31516" checksum="29BB7BBB618F5B3D" modified="2015-03-04" version="1">MQLTQKLILLLLGSNIEAAIPKDAVLLSQVRTLTLRADAKTSHRRVPAIPQLTCTGPGCSFYKVDLMRCKNQGSAYNPEDVEWSCTASIPREFKLGSTDVICEGYSNRNDNKILKGSCGVKYRLLFTEAGEKKFGGYYKFRTAELSFQNLMFMVAFIGILFWILYSALRAWPTGNYFRRFGRLWGGGGGGYPWDPPPPYPGKRYGSDQQQAGWKPGFWTGALGGAAAGYMAGNRSSSRGFSFTERREDFFNERDNHTRPRRVTSSSSSTNYESTGFGSTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P626</accession>
    <name>A0A0B1P626_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P626"/>
    <dbReference type="STRING" id="52586.A0A0B1P626"/>
    <dbReference type="HOGENOM" id="CLU_025895_5_0_1"/>
    <dbReference type="OMA" id="NIAILEM"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46948" checksum="4BE2A91C248348DE" modified="2015-03-04" version="1">MSLNFVTFNQDYSCLAVGTSRGFRIYHTDPFAKIFSSDDGNVALVEMLFSTSLVALILSPRHLVIQNTKRSSIICELTFPSAVHAVKLNRKRLAVILEEEIYLYDISNMTLLYTISTSPNPNAICAFASSSDNCYIAYPLPKPREETAHRRPSHAPPLSNYVPPTTGDVLIFDTLKLEALNVVGAHRSPLSCIALNNEGTLLATASVTGTIIRVFSLPKGTKLYQFRRGTYPSTIYSLSFNLSSTLLCVSSATDTVHIFRLTNPVSQNLHSVKSSVCVGNQNSQSYSTNLDTLKQSSSIEAGSPANNQKFSSTLGTMFRRSSLLVGKSVAGIVGEYLPQTVTGIWEPMRDFAFIKIPKSDIGTSPSVEPLRSVVSMSSNSPQVMLVTSDGGFHVFNIDMENGGEGILVKQYSVLEEDDKIRYFTANNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B8</accession>
    <name>A0A0B1P6B8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001762">
        <property type="protein sequence ID" value="KHJ32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6B8"/>
    <dbReference type="HOGENOM" id="CLU_806972_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="344" mass="39785" checksum="DF5BFE7275124292" modified="2015-03-04" version="1">MLNPDSTSQKARRSTLESIPRLINPRLLCVPETFSQPSLDAKKPDHSFVKHSKEYHKDAHSQNYKVLSRNVPERSSKYDAGSVHAGPRRNFSQSANHNSVKYGMKNKAVRAGEFYAEKEWISNCVSELYSAVIDLHTASITINRRLDDTYYSILEKLTSIQSTIVSLKELAAITRQLNVRLLSECHKVAHESNKQLDSFESFQNQATRIKELKSRVDIGRQNFLGLIDRVRHVQKRVESLEMNERKWRNTTRKRLRIFWSCLIGILTLTLLFYLLSWWVTEHADGKPDLYLTAMQIDSPKAKDINLKDLNKPILNLKAEVLDETINRCSRMSDKYQSPRVLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6E5</accession>
    <name>A0A0B1P6E5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sucrose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002009">
        <property type="protein sequence ID" value="KHJ32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6E5"/>
    <dbReference type="HOGENOM" id="CLU_1714664_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="153" mass="17097" checksum="2DD00A91408BF115" modified="2015-03-04" version="1">MARFEAEQKRKRFQNSIDHPSTKTTTQHSDNSQDCKGNLSSTKIKPDSESGKEAEGEKSKYEPVQPFRSLKGDRFRNFTYDAPAKSKSSLSRGAGVNAQYALHVWDSQEDSHHPSLQDSIQPRGSQSSSFLHHFPLSTLFFTKPPTIGPGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6I0</accession>
    <name>A0A0B1P6I0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001190">
        <property type="protein sequence ID" value="KHJ33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6I0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6I0"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="22172" checksum="2E37306C4799E72D" modified="2015-03-04" version="1">MELDVDPIAPSTTARSTPLVPPAQPPLPPLTTSSNTVVNEEEKSSHVPRNILNPVAPSKRAAQYFTDCMTHSLRDEAQQAHAYLPNELQAIIQRRQDQERAWHARLSICASVICNVESTLEMYKRDVEKQEAEFMRNYIRKAIARLASSDNSPKPPQIPMNTKPRQTKDFCQEKNSEKNNPPTGLYKPPKDTPGQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L6</accession>
    <name>A0A0B1P6L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000947">
        <property type="protein sequence ID" value="KHJ34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L6"/>
    <dbReference type="HOGENOM" id="CLU_010732_0_0_1"/>
    <dbReference type="OMA" id="GANACKE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="706" mass="79277" checksum="8CABB2464469B697" modified="2015-03-04" version="1">MSFLDLSQSPEPLGLRQNELVSSKFRENKTNLPTMKEYEETSNKSKIPNNIPTHPIACMQGAFAESFLESNSGVSSPTFSRPESASERRQQLLEQDVTEETHAARWKLKEGQKHHELWKLMAQISFGVYLLLNGIARDEAQVMKILQVHVDEADGFLESTLKDFELAQQDIENRLISLKPPLLNLSVFDMMMEDRYFRGFIVQGNEWVERVITRTASAMNDALRDVHHGANACKYFTIYLKKEHENLLWKDKAGMRGFYEAMKGNVDGWYKAFVSLLLKGKQLDIALVQLGSIVSELDRRAGEVSRMTRFSASASPSMSDFSTNRSSIRENRTAQEIHQSLSEGYKRQTALVTSKSEQPQKSECFSGLEPLIMAELEAPELLLKPCTYSPLPSSKTNSTNTFSNSTHQSVVELSAPLSSTNLSNLPEIQQSPVSQKQPSILNEDSFSGKNEKHLVDIVSNQPATTHITVSNLNSLGSPKAIQTPPSRGLDSAYCSDLEKTSPQLFTPKPTPKIQQEERFNTTTTVCELSNHVEKMTPSLLTPISIQISDSNYFRPVNASPNSPLQRPWTASPTQNPLHARPDSSGSNLSNLSAYSRRNGSTNISINGNKKKSTGTSRHTPSAMGKNVLNQTDDKVPKKRRGMLNWLKDQFCLNEEERMRFEQKLKANKDRLASTKTNRDSGYEGRKWIDGKRVERGKLGKNGRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M0</accession>
    <name>A0A0B1P6M0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001676">
        <property type="protein sequence ID" value="KHJ33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M0"/>
    <dbReference type="HOGENOM" id="CLU_1103462_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="24088" checksum="F461873136FCD359" modified="2015-03-04" version="1">MNAVTEIANVFCRMCKKNCPESFSNPASNTPHVTCLDCRTRNHTRRFPTVFEPIPNQGPSDFIEDVDDANDEEVNQLAANIGMFEIVEEEVFNGPVPEEATTGNDPIFMISQLQSREFRNHDEIQRRLQADENANGIYNPDDAPQVDVTNLQDRVVNDVIVSETDPNIDPFLEDFPPPQLENDNLQENVILNDPFVEENPHPPNNQVVQSQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P3</accession>
    <name>A0A0B1P6P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative duf221 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002187">
        <property type="protein sequence ID" value="KHJ32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6P3"/>
    <dbReference type="HOGENOM" id="CLU_009187_1_0_1"/>
    <dbReference type="OMA" id="VVCAWAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="201"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="381"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="951" mass="107926" checksum="32F0C2223B95DD0B" modified="2015-03-04" version="1">MDEISKRNAGASLVLDLLRNPFQTQLAQTSVIASLGTSIGFTALLTIGFSLLRPYNSVVYAPKLKVADHKHAPPTLGKGIFAWFKPLLETSEKELEDVVGLDALVFLRILAMCRNIFIATALIGCFILAPINIINGTQKNAKFIFKVTPINTFGRANWGMAICAWLFNFIICGFLWWNYRGILELRRRYFDSPEYQLSLHARTLMLNDIPRQYRSDEGINILIDKVAPTSSFSRTAIARNVKDLPELINDHNHSVRELERYLAKYLKDPKNLPAHRPKCYPSKSDPARDTYPKGQKIDAIGYLTLRIKQLELEVQQIRMAVDNRDPLPYGFASYDAIEECHAIAFAAKKKQPHGATIVPSPRPNDIIWKNMPLTKAQRRTRRIINNMWVAVLTILWVAPNALISVFLMSLTNLGHVWKAFRDSLAANTTWWSFVQGVASPAITSLVYLVLPIIFRRLSIQAGDRTKTDRERHVAGKLYTFFVFNFLIVFSMFSTIWNFVSSVINATSTGTDAWQAIFNAEFGTATFISLCDISPFWITWLLQRNLGAAIDFSQLWNLVWSTCVRKFSNPTPREIIELTAPQAFDYASYYNYFLFYSTVTLCFAFLQPLVLPACALYFAVDYYLKKYLLLYIFITKTESGGMFWQMFYNRMVFATILSNLVAFLALWVHGDNQHNEAYMIVPLPLMMLAFKFYCKRNFDDKIHYYSTHSLLKDPEICRLSRNNGKKDRLMARFGHPALYRPLITPMVHAKAQNILPSVYSGRLTSNTLNDSSEVTSIVEYSDAYMLHNMQQGAPGHKSSIPGFEIVPENRLNFAYYKNYHEFSDGHGGSGGIFGKPEDQIFTDTQKAIGSNQSNNDIFRLRNHASPSISSIEGSYTDELDSRGAFTLKNDERRGLIHGGIQQSLYSPNLASDSRKTSEDLMAAGGLNNFFRGYSKLPRNVATKPVNSNKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6V4</accession>
    <name>A0A0B1P6V4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6V4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6V4"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="26908" checksum="722DDFD06620C6DB" modified="2015-03-04" version="1">MASGYDRALSGTCAVGVKGKEIVVLGCEKRSAMKLQDTRITPSKIGLLDTHVCLAFAGLNADARILVNKARNEAQSHRLVLEDPVTIEYITKYVAGVQQLYTQSGGVRPFGISTLIIGFDHNDKTPRLYQTEPSGIFSAWKANAIGRSSKTVREFLERNHKDDMDREATINLTIKSLLEVVQTGAKNIEIAIMAPGKPIEMLPVEDIETYVKNIEQQKIEEAAKKKSGRSSGAVGATSTNRATDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W4</accession>
    <name>A0A0B1P6W4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001108">
        <property type="protein sequence ID" value="KHJ34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W4"/>
    <dbReference type="HOGENOM" id="CLU_105983_0_0_1"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="16107" checksum="4719AB5C099DE342" modified="2015-03-04" version="1">MGKRKAAAKKPVGPRKNAPLPTVFPCLFCNHEKSVMVKLDKKSGVGHLNCKICNQQFQCAVNYLSAAVDVYSDWVDACDAVAKIDSEQKEQSQTATRSFGKGGSASFQGTSFKRGDENHDRRNIDQRVTSGSNYTSLHTKIDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6X8</accession>
    <name>A0A0B1P6X8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative extracellular lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001098">
        <property type="protein sequence ID" value="KHJ34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6X8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6X8"/>
    <dbReference type="HOGENOM" id="CLU_032957_3_1_1"/>
    <dbReference type="OMA" id="CATHCKE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="456" mass="52259" checksum="9D9256371AF5F4A3" modified="2015-03-04" version="1">MPKYVHLEFRMFQWLVTSPNTISIILLLILTTLFATSAGAHQSPTARSQQLEESLQSDALWNSNITHDLFDELKELALIADISYCVGIFGISKPFVCATHCKEFLNFELIETFHSTYSPFGNCGFIALDHGSGQNDGRILVVFRGTHSITDAILDLLMMPQKFTPYPSDLQNEYMNSQSNFILQPLHDIIEWPVQRFIRWIFRQSQTTKSQGKHYTPKCKNCTVHLGFWKSYKMIRHLVLPNIQKLRQEFPEYQLNLVGHSLGGAVATLLALELESLGYSPKVTTFGEPRIGNYGLKDYVDTVFNLRSGDSNSQTNFPSSKSRYRRVTHFSDPFPLLPMEKFGYRSHAGEIFISKKKVPPAVENVRLCFGDDDMNCIAGKDTYETWEELLEVIRTNIEKRNSSNVKSINELKKRKENRILPLDLLQLYLGHVDYFSRMDLCLLPGGKNMEFGRDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P799</accession>
    <name>A0A0B1P799_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative duf895 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001566">
        <property type="protein sequence ID" value="KHJ33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P799"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OMA" id="VSEHAYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="59517" checksum="23FBCA313F2D5259" modified="2015-03-04" version="1">MIGNTQIQQDTVSTLSNKKERHNIEVPWPNQMKSSENNEKGHVVKRRLMYRDFQIGSIHIPCYASPPVQLFMSSIVCFLCPGMFNALAGLGGGGKVDTKLADEMNVALYSTFAFFGFFSGPIINFLGIRITLAIGGVGYCVYTASLLTSVIHPDNSSVYAFNIFGGAFLGFCAALLWTAQGTIMVSYPHEHQKGHYFAWFWAIFNMGAVLGSLVPLAQNFHVTQNRTVNQNTYIIFLVLMILGSVLALCLCNAKNVVRDDNSRVILMKNPTVCSELIGMWETIKFEWTVIFLFPMFWSSNWFYTYQQNGINAAHFSTRAKALNSLLYYSAQILAAFFLGYCLDSDYKSRVWRGRVNLVFLFTVTSLLWGIGYLWQRTYTRKTVTDQSFSPTDWKSPNYAGPLILYICYGAYDALWQASVYWYMGALSNSGRRIANYIGFYKGLQSAGSAVTWAIDSHKINYMSEYASNFGLLSGSLLIAAPMIFFKLKNTANLEGDILNTGEDIEKVRPKLELTDNTTSKQVSYRARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B8</accession>
    <name>A0A0B1P7B8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 50s ribosomal subunit protein l15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001974">
        <property type="protein sequence ID" value="KHJ32574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7B8"/>
    <dbReference type="HOGENOM" id="CLU_055188_5_0_1"/>
    <dbReference type="OMA" id="VVTRYYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="114"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="33375" checksum="FA8F4A4D0805B116" modified="2015-03-04" version="1">MSPRPSFLKPLLRAVTVDKINKLYRQPFVFCHTYLQCRTASILASLSDCPGAYNKRIRRGRGPSSGKGKTSGRGQKGQKAHGKVPALMQGGQTSLNVVHGERGFDNPFSIEMSVVNLDRIQSWINQGRIDPSKPITINELVKTRCIHGIKDGVKLLARNKDDLKTPINILVSRASATAIKAVESIGGTVVTRYYTRASIRRILKGESGSTSTPINETLATRLSSDGMCIQTSLDDFEYLLPDPSSRKDLEYYRDASKRGYLSHLVAKGHGPSLFYKSPGKVLKVRQKTDKKTAKVSGENQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7N9</accession>
    <name>A0A0B1P7N9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001881">
        <property type="protein sequence ID" value="KHJ32684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7N9"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="22665" checksum="09B6088D83789F05" modified="2015-03-04" version="1">MVKGQVEVSNSMLTDEIERVCSIRPDHVKLYGRNKEEAPHRTWMAYFTKAPRTGFRIYDESGIARAFKRQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHSEDLCMATTKCRNCGGPHRSESRRCLARPTRAGAPTKEQMKTFRQAGEREYQAVLRAKQAEKSAASAENNNVDLTSSQDSDNIDNIPASPIEISTGDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7T8</accession>
    <name>A0A0B1P7T8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001453">
        <property type="protein sequence ID" value="KHJ33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7T8"/>
    <dbReference type="SMR" id="A0A0B1P7T8"/>
    <dbReference type="HOGENOM" id="CLU_1897736_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058959" evidence="2">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="134" mass="14706" checksum="425EBFC3CBBFBC6A" modified="2015-03-04" version="1">MKLSYSAVGILVALVQLGVNSIAFSGYNCDGVFINDDYLRGLNKEIARERMDRSMQSRQKFSNVQKGSPSEKPYLLWPIAPTSKGYHKAPQGTIKAVISGPYNNPQAVSVVKMSGNHAIPCKVTKFQADVNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P842</accession>
    <name>A0A0B1P842_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001612">
        <property type="protein sequence ID" value="KHJ33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P842"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="22460" checksum="80AB51F4B21D5A8D" modified="2015-03-04" version="1">MISSIDSTLANFKEEVEIEEIVTFKMFLRQAIANFAAADSSSSPPLIPSHTRPKKWNGNSNHKDKDKNLKKVLVATPYIRQSPTNKTATSGPDQRLFVRVSQEHEWRKLSPAGIREVLVRKLSISPTLIGRIKLVHSGFALSPCSVEAREAILNAGNGLFLTGAKLESATNVKPTRLPEPDKLLTRRNPDRKVRGKLIVGGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P859</accession>
    <name>A0A0B1P859_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pyruvate dehydrogenase protein x component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001804">
        <property type="protein sequence ID" value="KHJ32809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P859"/>
    <dbReference type="STRING" id="52586.A0A0B1P859"/>
    <dbReference type="HOGENOM" id="CLU_035825_2_0_1"/>
    <dbReference type="OMA" id="DGIMMKI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="428" mass="46551" checksum="33DE3F960A386BD7" modified="2015-03-04" version="1">MASLSSVCRLNVRLMARKLPQKKIFRGLRTSTTSHVAQNLTMPALSPTMTEGNIAKWNVKEGDSFTAGDVLLQIETDKASMDVEAQDDGVMAKIILGDDSKGIKVGTRIGVLADVGDDLSKLEISIEDSTSAIAPKEQSGPKIEDTNHAKSSATSESKLGSKPNSALNLGKKQAYPLLPSVQHLIRLHNIDQSSIDKITPSGPNNRLLKGDVLAFLGQVSKSYPAQLSGKISNLSHLDLSNIRIKTPIIATPKTAKTTETISPTPEAMVILEQPISFENIYEIQKKMKSILGASLSEEKLISRATYLANKSVPRPKSYKTTKNELFEAVLGIDKKSTPKIQLFSPTIIPPSLSSACISKQNPAKKIDIIDILSGKKRPSSKLQINEIKSDSIHKIFKLEVAKSDEEKARIFLGTMKTTLESQPGNLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C3</accession>
    <name>A0A0B1P8C3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gpi-anchored cell wall organization protein ecm33 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000611">
        <property type="protein sequence ID" value="KHJ34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8C3"/>
    <dbReference type="HOGENOM" id="CLU_035846_0_1_1"/>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080538" evidence="4">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="397" mass="40624" checksum="CE2449693401A9B3" modified="2015-03-04" version="1">MFIKALVPAAAYLVGISIAQSSSLCSQPTATINSQADASALASCSVVNGNIVIGPLAAGVISIDGPQQLNGNLNCENAGGLTSLGSTTINSISGAFTLKNLTLLSTLAMGSLKSVNAINWEALPALSQLNFPATVTKAKSVLISNTFLSTLDGINLETVQTLGINNNNRLKTFSTQIANVTSSLDINSNGNNLDVSFPNLVRAANMTFRNVSTVSIPSLAIVDGSLGFYGNYVPSIIAPNITSVGSKADGQGSLAFVANTKLTNISMPLLKTVGGAVQIANNLALSGINFPSLSYVGGAIDFSGNFSTPELPALENVKGGFNLQSTSSIDCSNFDSEHGAGKVIQGVYVCKTTSDAAGLGSGTNGNSGSKKSSASTNQYNKITHCIFILAGLAYSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K9</accession>
    <name>A0A0B1P8K9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cell cycle checkpoint protein rad17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001678">
        <property type="protein sequence ID" value="KHJ32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8K9"/>
    <dbReference type="HOGENOM" id="CLU_006397_1_0_1"/>
    <dbReference type="OMA" id="YNKREDP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="248"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="874" mass="97605" checksum="C39C56A3BF73D623" modified="2015-03-04" version="1">MARPSKRQKCDNWSSEFITLQPKPDSISSSPPKQRVSNSTSSFKEPRKVSTKISQSRARAAGYLKRPSSQIFAHTRDTKTTDSITQSPEKPKHKSKIEKTKGRDISSFYPISTQRNKPIAFNTASQGTEYSSQNLKANSTSNDDIISDWDEDDLEFSQHSSCVPEVETTKFAYHDQSIKLRNKNLGSSSTEGIRKFHHPKLDESEIHNGSRTWAERFAPVNFQELAVHKRKVADVKKWLEDVFGGKTSQRLLLLKGVSGCGKTTTLRLLAESLGCQVLEWRNPVGPLASSDGCLSMSAQFDEFLGRGGIYGQLDISPVLEAASSVKKKNKMHERKSIILVEEFPSNLSSTSITLQAFQSSILQYLTTQTQQNYFSSNKNSIHSVAPVVIVVSESLLSTSTTMTDSFTAYKLLGKTILQHPGLRTIEFNPIAPTFLTKALELVVQKESRKSGRKKTPGPRVLKQLGEIGDIRSAICSLEFLCLRGDSDGDWSAKVSFSSSKSKIKEAAMTKMEKDSLELITKREFSLGIFHAVGKVIYNKRQDSPSSFSMDWNTEDLPSYISFHSRPKRPVVSVNNLIDEIGTDIQTFIAALHENYVPSCNASPSCFEFSTLDHINGCIDALSDSDLLHPPCSESHTNLGNDSLYSNEISFQIAVRGLLFSLPNPVSRKAQEAMTSSQKGRKDDAYSMFYPASLRLWKIKEDFETTVDLCCNRLLKGTNQNQIGLVALQEEGSGQSVVGTVETWKRNPSNQCQTAAKYGPFGMATSMSRKELILERLPYMAKIIKKRKYSGFPIDIEQLEKVTSFVGTTANKDFLDDYNLTGKVDRNCISNEFFDYKKTKKSSILQQSLGYKDSLPTQHKLDLKLVLSDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Q4</accession>
    <name>A0A0B1P8Q4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000780">
        <property type="protein sequence ID" value="KHJ34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Q4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Q4"/>
    <dbReference type="HOGENOM" id="CLU_034472_1_0_1"/>
    <dbReference type="OMA" id="PGHWGEE"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="47259" checksum="9D2672BF45AE0DB4" modified="2015-03-04" version="1">MLWIARYDRSTSLLRYTNLYFNAKYQRLSPKNKLCLVSLSSLASRAANTNVPLTEKVRRKIWGTDQPPGQADPYGENYNLKKSDQTTSEPRPVETRIQKPLVNESVSQYEPATIWDGLEQVGGTEHMLNQEWLPGNTFHASFIPKDKMVDIDKITATVHRVLVEIFVWQQANYQLANIFAGPELKTDFTINVNLSYSPKMGIKLQYPDNTTMENIIRSLTPGQLEEVTIAHDSDLSLTPKGDISINTTDISKLDSVKESEENIVDLQSVSEPCPLEETSAENPHNTKETNLELINYQELVASWDPSWMNIPIIDAEIKFTFFKRILQLTGIHVSDAIITSTTTVGGLLKQIIKPPKNRKLAEVLAEKEELSMLPNVSIHPRRITLRDRETRVGRWKLIEQEFIARGLISEERRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8X9</accession>
    <name>A0A0B1P8X9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8X9"/>
    <dbReference type="HOGENOM" id="CLU_023360_3_0_1"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="58470" checksum="96C01A55FB8AF88F" modified="2015-03-04" version="1">MSSPRNELNERSTSIKKNEGQKKKKNLYQIFTYKFTNTILLIAQQIGSRFLTFIANQILLRYLSPDLLGISMQLELYILTILFFSRESLRITIQRQHIESSITHQSQYKLITNNNVNINSNNNDENKIKNKNFEMKKLFDIQTASGQIQAIINLTYISLALGIGISFFLAWLFLGSLHTRDLAIIEMPNLRISLILFGCASILELLAEPCYVVVQLKSRHYIRVASESTATVFRCLTTCISAIYASENHLEIGVLPFALGQLAYSISLLVVYYLKVIQISSNEEFSLLPRPIYSPLVARLILQPIEEMSRNYFGKLLSAADNNSTKVIIKVRKSLFQLFYSYLIFSIFVVSLGPTAAPFVLKIIVGPRWSETGAGKVLAFYCYYIPLLAINGLAEAFVSSAATESEIHHQTAWMFVFSIAFSGAAFLFLKVYQIGALGIVVANSINMIFRITWAIFFIKSYLWRWQVNMKLESLIPRPITIAAGIAVSAILPQLEIDDHSLFSLFKIVAAAAGLFVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P909</accession>
    <name>A0A0B1P909_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001427">
        <property type="protein sequence ID" value="KHJ33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P909"/>
    <dbReference type="STRING" id="52586.A0A0B1P909"/>
    <dbReference type="HOGENOM" id="CLU_016392_0_0_1"/>
    <dbReference type="OMA" id="GGWEILR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="731" mass="81658" checksum="F87EC37A8E63A0DA" modified="2015-03-04" version="1">MSLPPDLRVLCDQISSVPVVELPSLLPSLSQKILYCKGLVTSSTSQSDTPGVSVLVHKLKTRLTTLLNGKQPEGRFVAIVLIKAFIDIGGWDALKTSGPWVRGLLSILGKPDPFISKELCIITLTKLYILIYNYPNLVREIATPTLPTYVTTCLNLISTVSSKRVSSVPSTLLKAILHSFCTLIPRYASIYRPFSSQIRLHIGPLLAPSSSKIPYIPQSLREAARKLIVTLHETVPKTSCSVEWRKAITDLVHNIHVTSDQVFRSVTENWESSVGYGSEPVNIKKGAQDGGISKCITPWTSIEAGTDILIGLLELLAMYFLVGTSGPVTVPIAVIKDMMDRILSVLPNSESNDGEIMIQLNPSVGRDEKDILCCRLPYIHSAVLRLWLVIADRIEENFMPFAQECFDQMVWVFPHGMHIPEFRLAIFELMTQVLLTSGKSFDKAQIDRASIIIKSCCDELNSDRKFTDYLVESGNRIMSNLDENKNLIADLLRKQNLNFSNPTKKKESDVFSSASRLLPLFLSHISQEHFNLSTRSMIDRTAILSKNREAMLASVLNPVKGNYDREIPSILPYLTQAYASDDIVEILLRPRMPQVSLGQVKLYNHVSDKDISMAEEMDFQHEVVQSYRSTSDAETFTPDPTTNSMFDIIPPTLDQENEPTDSDLKNEYQCAPIALASESSSHKVEIKKTSENTIKDDRNLETFPEESNSDDESVHLTMQLDTDSESDEDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P943</accession>
    <name>A0A0B1P943_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001410">
        <property type="protein sequence ID" value="KHJ33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P943"/>
    <dbReference type="STRING" id="52586.A0A0B1P943"/>
    <dbReference type="HOGENOM" id="CLU_012774_1_1_1"/>
    <dbReference type="OMA" id="YEDHPWE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="102"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="757" mass="84875" checksum="3A537FAE7782F321" modified="2015-03-04" version="1">MSSKNTPLILKKEWYTRAKKKGQDDHNSAVNYDSDGGSYSETDHWEFIFEEKNDIFAGNEVPHLVVTEENTDFLSLSSMKTVNDNTESSQKNKIKGVRNKEFEIKIGDVVSVNCGEPLPWVALIRSFDNSIRPGPNSKVNILWFSSHKDICNKQKKRTDFLPNEIYLTPHKDSINLDTINGPVEVLSEELFNQKYPKTTSKKSAKFEAKFICRRGCETRGVAYTDDFVWEDIRPKTEEQAENLYQRIKAETMSRKKKLIQKRNTNTNTNNDLNNERVGTPRKKQKFLAVTPMKLKTPSKILTPSHKKVMVKKPLEFTPLGTRILDIGQVASSPFQTARCRLHVSSVPVSLPCREDEFASVYSHLEAAIIEGTGACIYISGTPGTGKTATVREVVAQLQAATLAEELDPFNFVEINGMKITDPTQSYSILWEALKGERISPTHALDLLQREFTNPSPRRTPCVVLMDELDQLVTKNQLVMYNFFNWPGLSHSHLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYSFDQLMKIITSRLEGVPGNIVEKDAIEFASRKVAAVSGDARRVLDICRRAVELAESESLIATNPTTPSKTPGRSKGIKKVSIDIIRRAIKEATASPLQNYLRELPLSSKLLLIALTQRTRRTGIGEETLGEVLDEAKKLAKQNTNCRENFEFLLTANPLQIPEIGTQRQNISSAPRVLAMSTAAMNLVEAGVIVLESKKVDRTGKVKMCIGDQDIRIAFRDDPEVNSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P963</accession>
    <name>A0A0B1P963_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001178">
        <property type="protein sequence ID" value="KHJ33870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P963"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17800" checksum="EA2A7020C251A51E" modified="2015-03-04" version="1">MAFFSKAPRCGFRVFDESGIARPFKKQQSLEFCKRCNGHHPAKNCSRAPLFGNCGSTNHATDNFLAATKCRNCGGPNRSDSRKCLARPTRSGASTKEQMRIYRHAGDREHQAVLRARAAEENAVSIENMNAELTSSQMQENTKTTDNIQASHFEDSTRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P965</accession>
    <name>A0A0B1P965_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative snf2 family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g0724</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000467">
        <property type="protein sequence ID" value="KHJ35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P965"/>
    <dbReference type="STRING" id="52586.A0A0B1P965"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="498"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="882"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="967"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1133" mass="128823" checksum="0E08B8C28B76483E" modified="2015-03-04" version="1">MKDAEGPPVKKRRFFTDQSDNLLNPLNPVTLSRENETSVLKTSNTTHGISLEIEPSHHATLPEPDESSGSEVSVSFEEANFESLVGKKVAPNLIKRLRDASGGRMEKAINLYFDGFCDSLSPSFRSKPAKLYTENIGYFDKIAKHSVKQNQIPKKSPHFTNLTWESRYIGAFGCDGWVTRSGTTLIKHGDVVRIERQKIQLPKSSVFSGKQGQSTAQAIPKFNLPISRRVDVLVRFTNSKGEEIGRIPQNSADWISTLIDQKICKFVGFCVYAPERLRSGDTVFLQLRCFLFRTAFNADNSKFQENRSTSIFEEKESYEEKQLGLRQASLVKLFKEINLIPSKSSETLEKQKRDKILQATGTDSVDQNERSKNKVVYGPETNGISSQVEEAEDGKELEQDQLDALYKKAQSFDFNSPAAEPPETFVMKLRHYQKQALYWMVSREKDSQNIHKELSMHPLWEEYTWPTNDADDKKLLQIPNEDKFFVNPYSGELSLKFPVQEQKCFGGILADEMGLGKTIEMMSLIHTHKSIDLNIPNLIPTPDDSIMKISSSQNLASSTTLIVAPMSLLAQWQSEAGRASKEGTLNSFVYYGNDKISDLRKICRRISEVPNIIITSYGVVLSEYNQVTARNHERSSYCGLFSMKYFRVILDEAHYIKNRQSKTAKACYQIEAEHRWVLTGTPIVNRLEDLFSLIRFLRVEPWSNFSFWRTFITVPFESKDFLRALDVVQTILEPLALRRTKDMKTPSGEALVTLPLKTIEILKIKLSKEEQEVYDYILNRAKQSFEANVEAGTVLKAYTSIFAHVMRLRQSCCHPSLTRNPKIVIDEEEANIETDIADGLKDDMTLQSLIDRFAAETGDSAGINIFGAHALKQIRDDAQNECPICSEEPMIERIVTTCWHSTCKKCLLDYINHQKEKGEKPRCVTCREFLDTRNLFEVVKDKDTSDNDPPKYNLHRLGTTSSAKIVVLLDHLKSLRRDAPGTKTVVFSQFTSFLSLIEPALSQAYIPFMRLDGSMAQKLRANVLAEFASSSKGVVLLISLRAGGVGLNLTMAKRVYMMDPWWSFAVEAQAIDRVHRMGQSDEVKVYRFIVENSVEERILKIQDRKKFIASSLGMMNDEEKKLQRLEDIKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P966</accession>
    <name>A0A0B1P966_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000703">
        <property type="protein sequence ID" value="KHJ34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P966"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="426" mass="48061" checksum="2FF50C8742C43D51" modified="2015-03-04" version="1">MNIDDAYLPKEITEIIAARRRQERAWHIRLSICASIYSNIVSTLSIYKEDTEREEAELIRKYLREAIACLAASNNASKPPKIPIATKPNKMKGSNKTNALKQNKLLIATPKHIICPNLQNVQAEIVEPARPQKQKEKSWAMVTRNGLKKSRISTPAVNPQNVISPNDVIHLTSRPKTHNKDLGKNVEVENKSDNRLFIRLPLDHEWRKLSPVGLREVIVKLDCQVEVSKLILMNEIERVSSKRPALVKLYGTTNPEAPHRTWLALFSEAPRCGFRVFDESWITKIFKKKLPIEFRKRCNGHHNIRNCSRALSCGNCGSTMHAQDVCKALTKGRNCGGPHRSDSHRCLARPSRYGKPTKKQLDAYRRAGDREYQGVVRANAAEARAAIAENTEGANETSSRSQETFISVENPNETPVQTQAGGEMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9E5</accession>
    <name>A0A0B1P9E5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001344">
        <property type="protein sequence ID" value="KHJ33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9E5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9E5"/>
    <dbReference type="HOGENOM" id="CLU_066274_1_1_1"/>
    <dbReference type="OMA" id="YASDFYA"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="191" mass="21230" checksum="1890DD17ECF517E9" modified="2015-03-04" version="1">MGSKLNTNKRKQSPEKRNYRKSKKRPSVYDAVAGRISASGFISNTKSIPNSRDTCSSSHVPLAPEHVLFRSKNAPTRFAEYDIYFANERNDVSDLPESDLLKALHTYTSDFYSKTTSNSGISDWKSLDGTALIALGILTEELVKDMIGETGDLALTEGQNTSAQDMLKASNSTSNDQPSRKKQKLERNNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAH2</accession>
    <name>A0A0B1PAH2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000957">
        <property type="protein sequence ID" value="KHJ34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAH2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAH2"/>
    <dbReference type="HOGENOM" id="CLU_029214_1_0_1"/>
    <dbReference type="OMA" id="DYFDCIQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="357"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="52000" checksum="11FCD82059DED277" modified="2015-03-04" version="1">MTPRKKKLGRITASKKKSITSKASEISESDCIATSGNTELSQVYKRRKRRLEVSNEISEQSCSDQENTHKINRHEVNETVVKDTPPEKITRKTGARSKIAKEVSAASQSDLQDSPKVHKTIVRNQPQRKGRPKKVTSPVRLSDKVILESQVTEIKELEGEDEDVEWDEIVQNEKPKANNYQRARKRRRTNSLSELENEGHTSMKRKIGEIKKRYQSLQLKYDEVVTLGIKEAEKNFDRLKKQNEEIISISNKCLSSLKTDLKNQTTLANEAKSLERKLSAAGTEIKSLEAKLQYLETSLADSKAENKTLSTKLAANRTAAVSVESVNSKIPSSTIKANGGIRMMGSVEAALTAQAAQLKEDMYSDLTGLLMRSVTRGTDKDYFDCIQTGRNGTLHFKLAVGNEASADSYDDIQCSYTPLLDSNRDKMLMELLPDYLVDEITFPRPHATKFYARVVKALTEKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAP2</accession>
    <name>A0A0B1PAP2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytokinesis regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001265">
        <property type="protein sequence ID" value="KHJ33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAP2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAP2"/>
    <dbReference type="HOGENOM" id="CLU_008906_0_0_1"/>
    <dbReference type="OMA" id="DWGEGSL"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="990" mass="111295" checksum="0327219E648A6C2F" modified="2015-03-04" version="1">MSQIENWDDDDLDFEGNDFAFRSASIATSMATALSNRRGSMSSHISARSDMESNNGDEERQVNVLGDDERSRNDAIAAANLAGIPIPHNVPNSALIGGTIKRLGGRKITKTIQDDWDDGDLEFSADSELKIKIHEDTSFPESLRQVSGPSSTQSSPSRQRMSALGSCYDPHLRLRSSQALNTLLNQYKDGEDKDYTRKNMIKISKNRKNPRLIPITTSPTLYRRQQAVEFEDFEQDFQLPQDDAPLRLSLKIDMPMTPNSIQDESDEWGEGGSLGTRHGGKRDRTSNRGSSVTAMSPSVSSSLTLESEDEGLDGLLIPNDPIQFREILKKKHGHTSFQNIKGNLPTSESKDDFFSGLDIGLGDIFDPTKLTMNRNVKVKTTRQASPARPKAAVSLTFTNRTNTSSNSRLPRPPGTYERIPSSLESVPESGGPILNRNHRFNSRPGGHSSNPSTSSITTPSTPSSSTIPPFTPRRRELVSKTSLNTLHQEPTTTSAQLLKVKRSMPIIRSYPSNVKSSTNQRYDKPPLYFDHYRPISFSRPKTPVEYKRGTETCHGSNKLHQTPFLPAGTSNTQSYNKLAKNSHNFKQQISEQPSNSSERQFSSRAVSRSTIRSSSPYRKGADALAREAITKRLLTKPVRGRDFGDGCELDAFDDLPTSRESEQNYIKEPVSRGPMRPNSCRKPIEQDMKVASINSSVPLTSKRSRDTLPRFARDTTASRLARENTLAQRVSLSKGAPLAKLTNQWKAKVNASTGLNSCKVRLNKPKKNQRLPQKPQLIKPLGNCNNPKSLKGMYYNPYTYRWEGNECDLSQFDLPSSPSTCSIPSSIAYKENRHNYREKETSTPRPALIQHVKSMHNVQVVGGMVFDPQRMCWLKISSQQRKDINSLDDIANSIDSFNDDEEDVFKDVPDLEESRACDPSTGGLKNDNYREDFLVGEEFDVGPEFIKRQREEEERWKRKLEKWIQAEFGIDRDNPDWRWVIRGMVLNHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBK1</accession>
    <name>A0A0B1PBK1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000315">
        <property type="protein sequence ID" value="KHJ35638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBK1"/>
    <dbReference type="HOGENOM" id="CLU_518948_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="525" mass="61320" checksum="C06AB4FE9DCBBFEE" modified="2015-03-04" version="1">MLAWGSIRVLRVALGLPKIQKSPQLCLIHLQHAATTKHLTGNHHIIEYKDFSYPDSKNYELELWTSKPPRKTEDRISLSNVLQDYLKPGLALLPLESKTSAGLPEINIPRYRIGELDTNKVYQTKNQKGKGRGSKEFHFRTDVETGHLAHSLYKSYHFLSRKTNRSRIEIHVHYPIKKKKKNNLPSLGSSTIQQRKEILEEHKRSFLNAIHNALHLWPETILKAMPQGSSITISPVANKDNVCWVMDLGGKDSTKLFQKNRSIHETRYENCEGLPDKDTRRNVKRDLREVRLQVREEIEAQEKKEKIEKKASLYTEKKSNTDIHESKQPHRGNPTFKSLVSEISIEDIRDSTKNPALVQLRALIHDLVQRKGTVRLFEQCDFEMLSRPEMMKIILIAILQVCERVNELNYQIEHGTEKVQRENNIILERTESLYKDHPNAKQLQEEIKRRLEVDLNKVNRKNKDKIELESRKLLRRRYKLLDSLESDERKMVTRIEGGRPLILFNSVKKQKVGWTWQSRGTSKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC63</accession>
    <name>A0A0B1PC63_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC63"/>
    <dbReference type="STRING" id="52586.A0A0B1PC63"/>
    <dbReference type="HOGENOM" id="CLU_027451_1_1_1"/>
    <dbReference type="OMA" id="RVWVNQL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="258"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="436" mass="49482" checksum="4230509F494981EC" modified="2015-03-04" version="1">MGIPIEVTEKCKILTSDSKPKKERSTKKRKLTISSNSQLDDVNIIQDKNTDEKTDQQLGSLRRSSSKEIVNEISEKRSSTKRKTIPDEIEVDITAPEPPSKKKLRLLNKKKPSLSVKLDKTTGDPNDIKKDKEFGTKKKSNHGIWIGNLSYQVSTDDIHKFLVDNSEISDDMISRIYMPEIRGVKSTQKAAEKNEKKVTNKGFAYVDFSSAEAVNLAVKLSEKLLFGRRVLIKDNKSFEGRPDKGKDELKVNNEPLSKKIFLGNLSFDTTEGILKEHFERCGAIKTLKVATFEDSGKCKGFAWIVFEEIQAAKNAVRGFIKINNTIDENISDHTSEEDSSKKSSSRPNGKKIQSKVWVNRIKGRTLRIEFAEDAQLRYNKRYGKDRTKNSRDINKETQGTTDDNQVKPLKKVDYRQEYAPRLTGGIIESKGKKITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC91</accession>
    <name>A0A0B1PC91_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000975">
        <property type="protein sequence ID" value="KHJ34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC91"/>
    <dbReference type="HOGENOM" id="CLU_2028441_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13361" checksum="5E3283BBFB260DCA" modified="2015-03-04" version="1">MDSTNNLSGELIGASSNPSSQSLKAVYTSRSETAFACSESLSLDTNPSSDEKKIYLSALKKAIAQMQEQINIQLTNRMENDAATSIQVAPEDVYQPTNEIYIPGYECEEDSELIKCEGEIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCC7</accession>
    <name>A0A0B1PCC7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nucleoporin pom152 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000967">
        <property type="protein sequence ID" value="KHJ34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCC7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCC7"/>
    <dbReference type="HOGENOM" id="CLU_002415_0_0_1"/>
    <dbReference type="OMA" id="DRSNCKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="194"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="441"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="554"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="665"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="756"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="874"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1250" mass="141137" checksum="0CE983B08FD39976" modified="2015-03-04" version="1">MNRTPRLRSSFPSTPGSNKTDTTKKDGGKILLTLSELPTDSSNPTPTSPVIPVHILDAPSQRLYTSAIYCALLAYRLYDWWSLVQDDSTSMGLFLKWCSIDLIFLYGVPMLRIPWLEWSNFTSVLACLLHAIFNGFLMFRVHLPFESWLLILVKTVFDREISISENSVRPARILHNSSLIMGKQIINILPEGYAVMNPDRLPFCIDSSHPTVKIPLLFNQTKPNYIELVRIDFDSNINETIVLSQKEVKKIRKLQEENLLSIHYATKKPGLYRLHKVIDNTKLEVQRKMSDTLVLKCPQASIKSSTLNKCAGDLSDLKIEIEGTPPLKVMYTRVANGDQSVHYFQNVQPENFVSPLIGSKNSPLALQGYSDISWGKSHHISVPLNETMTVTGSWLYSIDQIHDAAGNTVNFSPGFYPVIEDGERVYPKDDRLEISYNVHDRPVAFFNMCDSRKPLMVAKGKTKEMPIEYRAASRKSTEQNFDDTSYAITWKFSASESLTKSGDHGDSAVVEDYFAYSSNDHPFIKKTGLYTLVSVKSKYCEGIIQEPASCLLLNPPEPDLSISAESISDNCAGNSVGLLVDLNLIGTPPFILKYDIITQSGTTSKHVEIDGLRYQLELKPMEAGHFKYQFISIDDEVYKEYSLLEKALVLEQDVKPPAFAELRFSQSTIDACLEEPVHLSVKLIGEKPFTLEYEVIHEGRRKKFTTSEIDSPTYTIKTDPLHKGGEYTLALTSVQDSKGCKIFLKSEAKFNVQRQRPKAAFGKFEGNFKVVAVEGREVEIPLRLSGRAPWNLKYSMEVDGIVKVMEKMAKSTNDVLKINQSGRYEILEVSDDHCPGSVDKTSSIFEVEWFPRPQVTLIDTAAITHDTEKYVKREICEGDIDTLQVKLIGSPPFNVKYQVLHKPIQGSGSIINRELEAALGSATISLETSKAGIYEYKFLELSDALYDHDGHKFSPVVIEQKVNRKPSAFFIKPGKSYKYCEEELDVDEAIPIKLNGVPPFSLELDIKHHSNSRPETIKIAIIETNHYNFKIPHHILSMGSHSVSIRKIRDSCGCHQKMEQGGPHVQVQVFHAPTIRPMDTKTDYCVGDRITYSLSGLPPFEIIYDFEGVQRKAKSTSTTFKRFAEKPGIFTITAVSDKASECKAQTFLQKVIHALPMVKISQGRQLEVDIHEGAEAELLFEFWGEPPFEFTYTRSSLITHKGQRSHVLETRHETSTEYTKLIRSSQEGIYEVIAIKDRHCSFSLANKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE0</accession>
    <name>A0A0B1PCE0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative serine threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000203">
        <property type="protein sequence ID" value="KHJ35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE0"/>
    <dbReference type="HOGENOM" id="CLU_007199_0_0_1"/>
    <dbReference type="OMA" id="IRSMPHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="791" mass="89057" checksum="BE55063DCA8E609D" modified="2015-03-04" version="1">MQTNRHKAESQSRKQKLADSYYELLQEFSSKDLKTVGNYALGRLIGKGSFGKVYLATHKLTNGSKVVLKSAKKDDPNLAREIHHHRQFFHPHIARLYEVIVTENLVWLVLEYCPGDELYNYLLKHGRLSVEKVQKVFTQLVGAVSYVHAASCVHRDLKLENIMLDKNENVKLCDFGFTREYEGKGNYLQTYCGTVAYSAPEMMKGEKYAGEKVDVWSLGVILYALLCGELPFDEDEDSATRLKIMGNEPKWPGHLTKDARSLLGLLLSKRPLIRPSLSEILSHPFLAEHAPQQLAILNIQYPPPFSTQLEKETLQRMRSSGVDVDQVVENVLAKRCDSLAGWWSLLIEKEQRKYLRRERKRKERESDNYGSRRLSAASFRLDRLTPHFSGTNEDEQEFRKTGSPRNRGRKEKRSTHFSDLFIDMHGFPEDPLLFSPNKLISPPSLDKESVRSASSSRNRHSIPPPKEGTIREARSRGSTLQLVTPNPDLLNVPHNGAVNRPSRRKNQHSFIGQLTHWKHWLINSTKKTTSPNKKISGSTINTEKNSFTNLKLDPNVSNSRLANFKTHTSKPTQSEKQQKNLQFKQINFTQARKRQSLSPPPTTPRGTLKYSSIGLRGRKSTSSSVSSIRSIQPNRHTHSKGSSTSSDGSISTKRASLPSRSPHHSVKVLPATPTTGTFPSNIRVVRQSTSSSFNEGPWGGNSNGGLIFAKRKKKVFKGPILSLSLPTSSLNLSKTHSRSTSQAGRGSGEIIQEENEDEVEELEKFSSLVGLEESEELKISCKTGDEISKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCV1</accession>
    <name>A0A0B1PCV1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000717">
        <property type="protein sequence ID" value="KHJ34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCV1"/>
    <dbReference type="HOGENOM" id="CLU_1587719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="19316" checksum="CB7A5D07AC5614B4" modified="2015-03-04" version="1">MMKNCLIQARGNGGESTQKRVTRIVRQTNANGRKLDMRRSADKQARGGAIGQCGRQSKKTGGRRTKKESGHSSVRGAAEERFCEERMKEYRKWLAAENEALIPTNYNLEGQGRQEEEEEEEEEEEEEEEEEEEEEEEEEEKKKTNGDVLSPYCDKSTHIFQSRTLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD33</accession>
    <name>A0A0B1PD33_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000811">
        <property type="protein sequence ID" value="KHJ34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD33"/>
    <dbReference type="STRING" id="52586.A0A0B1PD33"/>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001884">
        <property type="entry name" value="WD domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000755">
        <property type="entry name" value="WD repeat-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="434"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="656"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="836"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="969" mass="109459" checksum="3015F491B927488A" modified="2015-03-04" version="1">MVKSYLKFEQSSSFGIINSSTSNVVWCEEKAGTSQATRSGWAIAPANEEVLCWEIKKGELLSRWKDIDCKFQVTAISKSNADRDIFAVGYEDGSIRVWDFKTSTIIVKFNGHRSEITTLKFDGSGTKLASGSKDTDIILWDLIDEVGLFKLRGHKDQITGLEFFKPETNLDGFIGEDGQALVVSENDLEVSERFLLTTGKDALIKLWDIESRHCIETHVAQSNGECWSIGIFPDGAGCITGGNDGELNIWSIDCMGLIQYTKKLNTTVDNHFLKSRGTIQCQGRSKIRDIRFHFSHNYFAVHGNEKSVELWRIRSEEEIKKSLARRRRRKREKKNDNNEKEISEISLNQNIPDEDFKDLSSVDVTEFFLSYLNMRTSGKVRSVDWVKNKASKAMQILVATTNNQLEVYNIMTKDKLGKKTNEIPDYSRSLSVELPGHRADIRALSLSSDDRMVASASNGELKVWNVRTRNCIRTFECGYALCCSFLPGDKILVVGTKTGDLELFDVASAAMLDRIKAHESAIWALQVHPNGQSLISGSADKTVKFWNFNVIQEPILGSRRTMPKFSLSQGRMLKVSDDILSVRFSPDARLIAIALLDSTVKVFFVDSLKLFLNLYGHKLPVLNMDISFDSKLIVTCSADKNIRLWGLDFGDCRKAFFAHQDSILQVAFIRNNYDGNGHHFFSSSKDKMIKYWDGDKFEQIQRLVNHHGEIWAIAVSNSGKFLVSASHDKSIRLWEETDEQIFLEEEKEKELEELFESTLATSLEKDSEEDNTELGIVSKQTSSTLTAGEKIVEALDIGIADLEIVREWESAKIINPSLAPPSRNLTFMALGGISAEEHVLAVLQKIRAAELDDALLVLPFASVLALFRFLEIFATRSMDIQLTCRVLLFMLKAHHRQIISSKIIKATLQTIRSNLRQVLNRQKSEIGFNLAAFKVISNKVNEREISNFIDDEIDQEKCIQKKRGFISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD40</accession>
    <name>A0A0B1PD40_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000122">
        <property type="protein sequence ID" value="KHJ36173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD40"/>
    <dbReference type="STRING" id="52586.A0A0B1PD40"/>
    <dbReference type="HOGENOM" id="CLU_003244_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="675"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1176" mass="132985" checksum="67050975CC8B9B2E" modified="2015-03-04" version="1">MSVLSQARLAERNKEGRRESWLMGNLSRRRYRQESMTSINDEVDPGHKPGQLASPNTDITDTSLAISDDTIESPGNRRHGLIFQKSLSTSSAQANTRTWATKDNQSTRKQSSSDSNPRDKSSSESLSAGPRTSNLNNIPNTSSNTTIPQPRSSNSLRGHSFTKMLIQPTSRSLSDSIRSLSVNPSLLQSAAVDTKKIANLMNKLSGKMRGEAEYQVNFGVTNRGFFHVDDVNGSLIYEGDQGNTSLTVFKNLREVEVRPVQGSEGKFTSLELSNRAMGVHVLFRPIHEADLDHWLAALLSCSENKKDVQVLQRSKNKQNIVKVGSIIKVAKLFLWDSTTLLTTQFLYKNSSKQSNLRTRSSWRCVSCILQDNGQFKLLPENNSNPLAVIQLSQLSRCAIQLLDSSVLDKEFCIAIFPLYAMTSSQLSFFNPVYIASESRLMHEVWFCLLRAFTVPEIYGQWSNNSDDEINNSSILSESSFAHDVFRIEKSVKMRIVEAKFTNTLSAKMKVSNAGKSKKDEIETTVGDYFVEIILDGEIRARTSIRSETKSPFWGEECEFQNLPPHTPNLIIVLKKILPISAQNHLPQSNPKTNSSVETLNWTMEVPISKIERGEENEAWWPILDQQQERAGEILLSIKYDELVVLLANHYQTVSELLHNFSSGLTIQISQFIPSKLKLLSELMLNIFQVSGYTEDWLTTLVEDEIDGLEKDIPTDCHVRWTKKCIPDESIQAGMSDREQSVRDMGKTLQEEANLLFRGNSLLTQALDFHMRRVGKEYLEDLLLDKISEINFLNPDCEVDPSRISNNQDINKNWALLYSLTTNIWDSISGSAERCPSELRQILKYIRAVAEDRYGNFLRTVVYTSVSGFLFLRFFCPALMNPKLFGLLKDHPQPKAQRTLTLIAKSLQALANLSNFGKKESWMEPMNRFLASHRQGMKNFIDSVCAISAGQTTSNLPASYSTPITIFGRLPSISREGFPSLPYLIDHAQNFSKLVKLWVETTSKNPKLETLQGELLQFHQLCLKIQHRADECLQKAEQSNQNIYKQSRDILCSSKNTWGHNASNYDLNFEKQFRVSSSASIDSRRTRYPPISTDVIPLHKKGSVRSNNKELNKGKTTREQDHIESSPISSIREQAREEWPLKGFLGGLRRRGKENGDSQNRDHEKEILSASLNDGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEE4</accession>
    <name>A0A0B1PEE4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g2326</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000575">
        <property type="protein sequence ID" value="KHJ35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PEE4"/>
    <dbReference type="HOGENOM" id="CLU_000315_1_1_1"/>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1305"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1652"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1885" mass="211075" checksum="28C36CD2CC2610FE" modified="2015-03-04" version="1">MASRLLETGSTPLIRNTAAQQLADVQKAHPEELFNLLTRVVPYLRYKTWDTRIAAAKALGGIVDNAEKFDPNIDDHEESRICDKIKTEPDIKKELLVEIPPDNGQLNLETLDIVSILKYGKVLLRGGDSKDLDYSLAHLSPIQRLEHQKKTLNCRIGLSNEHYEEITPINSISKNGTKASRVKMPNNNRSDTKPSVPVEEQGLSARQLNQLKRKRKREAQIAGSKNRVLELSIRTASVVEPTELISDSTMTDIVDGNENAIQDYFSMERVGEVDEQTKIISEFKGPAVPIKVEIESKEEYDHVDWPYERLCEFLIVDLFDSQWEIRHGAAMGLREIMRAHGHGAGRVRGKSRYENSILNARYLDDMACKLCCVFMLDRFGDYVSDTVVAPIRETVGQTLGALLIHLPPVKVYAVHRILYRLVMQEDLQLQNRGWAVCHGGMIGMRYLVAVRNDLLLNDNYLIDGVIRAVMKGLGDCDDDVRAVSAATLIPIAREFVTLRPEALEKLINIVWECLSNLGDDLSASTGQIMDLLAKLCSFSEVLEAMKTNAAKDSERSFTLLVPRLYPFLRHTIISVRSAVLRALLTFVNIEGNGTTDWLNGKILRLIFQNILVERNIDTLNLSLQLWVALVTHLAKDPGHLAQEFSAHVDPLMQLALHPIGVSRHPLPMNASLFQKPSGNTYSLSTDFVSSVAKSYLPATIEPPPKKQRRKSTKNVEPMPVTSAHDVDGHMMHGDVDLVGMETLIRSKIYAARAMGLLMSFIPLEVLEFYDASLIPAFSSAFASTQLTSLLIVDEYAKNCTNKEPAIGKFMKPLQAIIESARPFYYRDLVSSMQLIRAQCSQLFNTFRDVGKISQSRLPVLAVVVQGEAEAGPDAFSLQIAERCVAEDFEKLKKSMSAAQRMIATQALNEARDNVLEAISNAKALKEQRDIRIKSSAASALVAMRASPKKPTHIIKGMMDSVKKEENFELQQLSAHSIARLVELFTEGGRPGPAQKIVSNLAKFSCIDTSETPEFIPNASFENNILSLRKEEDRRDHPDAAKFAREAKEARIVRRGAKEALEHISDIFGAQLLDKVPTFRKIMEDALLYSFSGDLPDNCKDPKQEYGQAAIDSLSVIRALVPKMHPELYSFITNLLPTIVEALHSKLSVFRYMAAKCLATVCSVITLEGMTFLVDRILPSISNPVDLNFRQGAIEAIYHLINVMSDRILPYVIFLIVPVLGRMSDSNSDVRLLATTSFATLVKLVPLEAGIPDPPGLSEELLRGRDRERKFIAQLLDPHKIEPFKIPVAIKAELRSYQQEGVNWLNFLNKYHLHGILCDDMGLGKTLQTLCIVASDHHMRAEEYARTKAPDFRRLPSLIVCPPTLSGHWQQEIATYAPFLTCTAYFGPPGDRVKLRDQLGKTDIVITSYDICRNDAEILTPFNWNYLVLDEGHLIKNPRAKITLAVKLLLSNHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFLDRFAKPIAASRYSKSSSKEQEAGALAIEALHKQVLPFLLRRLKEEVLDDLPPKILQNYYCDLSDLQRKLFNDFTKKEGASLINAACSGDKEAKQHIFQALQYMRKLCNSPTLVLKEGHKQYEEVQKMLLKQGSSLNDPIHAPKLTALRDLLVDCGIGVPPSSENDITTETNFVSPHRALIFCQMKEMLDLVANTVLRTLLPSIQYLRLDGSVESSRRQNIVNKFNSDPSYDCLLLTTSVGGLGLNLTGADTVIFVENDWNPQKDLQAMDRAHRIGQKRVVNVYRIVTRGTVEEKIMGLQRFKIDVASTVVNQQNAGLGSMETDQILDLFNLGDSNILPAPGDINQGANGTREEDMVDATGEVREKGKKGWLDEIGELWDGREYEESFDLDGFLKSMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEG4</accession>
    <name>A0A0B1PEG4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEG4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEG4"/>
    <dbReference type="HOGENOM" id="CLU_008719_3_1_1"/>
    <dbReference type="OMA" id="KECRWNA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="63084" checksum="458C2906026CB6A8" modified="2015-03-04" version="1">MDLNLFFPGRKSSRLCKRGIRLNFIDTTVKDPPLIPRTANWKVYFQDESRNIAAEYKGGLDKYKKFPSESASLSKLEYSSRLSSVAYQSEVNFANNNSSPRYDHEQNFEKKIAQKYSRSRQVSQYPSNFENEKNSNIPYFKAASSRNVSCANFDISVMFSKSSEELYLKTAQEVLLMQVFVEEVGIWMDSMDPMKYFSRKLPFLALQKPMLLNAFLACGARHLTMVNPKYHEDKALLYYDTATTQLLRALQDPERDSVFCATTAVILNVYEIMSERAMQRMNHIAGARALIRECGWNANSRGIGAACFWLNVGMEILSCLHFNWQVAWDPDQWGVDLNFKRELEFGKEEIWVHRILYIVGKIANFRASVPGVRDLLSFDEQKRLKIRLEEWLKLKSLCDVWDECVPRTMKPMGYLHPSQGTSQSAFPEIWVIKRATIVGRLFYHTAMILLAQIHPLKLRDTEEMQAVQLNHAHIVCGITAHVKDRGVASVALRSLAIAAECLVIRREQEEIIEIFERIRKETGWKVGFLYKDLRQKWGWEPTRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEQ4</accession>
    <name>A0A0B1PEQ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative centrin-binding protein sfi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000519">
        <property type="protein sequence ID" value="KHJ35119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEQ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEQ4"/>
    <dbReference type="HOGENOM" id="CLU_007577_0_0_1"/>
    <dbReference type="OMA" id="RFFNGWR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="1">
        <location>
            <begin position="365"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1041" mass="123206" checksum="FCC3641BA9066E64" modified="2015-03-04" version="1">MPRSGNPLQYNYGKYSSKTTEPYYSNEDIKILHQIVLKAQTLLSPTILPSNALFTAYFSTLEELQVHPDHDNRYARILFKIGGIRGVGSLLEKFENVISEMGIEIEFDQLSEEEEETEFHRIKTSLENFSTKFTFKTQPQYAQTSEKCNSEILEKDPNAEDTLQMQRRRINSFSSYPLSKAEFDGKNEYTPQRNKLQQFRGNSIYECPQGAQNARNFQHVGAWLASGPFHLPTTSISSRYGFQINKDTRKITNSRQNQVSLPASTDFHIASMTTPPSSPFDEETTVHSTGSSPKEFIQESETLLDIEASLIRNRHFALFVKSNLQSWKNQAIKLHNNSNKLSFIATNQYLNNILCSALHDWLDKVRNKRKERCNERYFNHLEISAKKARDLYLLYVSFSHWSNFTMERIQLTAKTRKHIIQNRMFNAWRDITAVDELKVKRQILKRIFFTLKSHHSSIKEKIKAANISYKSNITQKYFNTWIHKFLTIRIITWRTENLVNLILTEWISKSRFIGNQKNIAEISRQKKICVNTIVFWILRTKKSLEEEERARQFYINKISKNYTRKLCKEAVLMTAKNKIQNQIVLRQVGNIFSFWINQARNERIAIATDRMRILHEALTNWRYKTRALLFRLKLDNCIIERTIYTWILCARTNLAIRIRDENYLRDMTHLWNLKFQALKKNHSQQETLAREVLARRMKNFVLLRWYSCMGRLPQAKMLDLSPYKPRILKFFIQKWINDIQHLHKLERWSHDAGFFLLVSRIMRRWKSATERTRRNKRKYLYARVRRMTKMNLARHVLRIWARKTGNILYLKSQVTEINQSRMIFLKKYIFYSWHCYNDELLELKIMWQKNSLQKYVANWQDKTKNILALGLEAIIIYKESQISKILKKWSLRSLHVRAYENSATEIHDKKTRKKMRKLIIFWHQQVSLQKTAKSQVLSESDLEKIAQDEAWSELGEESNVENIEKILNREIIPSFVPAYLNTPSKRSERIKAAVAKYSKTPKTPLPISQDQEIRVMRSGGLFSSIQKKRASNLRMSDNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEV4</accession>
    <name>A0A0B1PEV4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000233">
        <property type="protein sequence ID" value="KHJ35840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEV4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEV4"/>
    <dbReference type="HOGENOM" id="CLU_017366_2_0_1"/>
    <dbReference type="OMA" id="DEFCAIP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059100" evidence="1">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="57526" checksum="058EA4F69E7D252B" modified="2015-03-04" version="1">MKPYVLLIFCTTQFLLASAKLQVPLLSSSTQVTPYAPSTSNAVVNAPHIFNTIHGAMRQWENSLKHNGMSIFSVTVAENTIFYHGDPIGKPINKTEWLAFEVEHAEAFFGLIPPKMGEDAIYYVENTDEQNYTGYLSTYRTTRPLKNVIYFNGISAAKSSFGTLDMQDRVLLQDNKFKSTPGFEDLHRAQEICKLLPLVDGIIRMELGFELIICDTSKNLELLSVTSHPQHYVRNKTENLFLRSEYMRGVSKRYLGLAAGKVSIDFSSMISAYFYPLNLTNPDPKKAELPRIHPEEKEKIRRLRNDVVNQFNNQDKSQSFIGWQSIVDDLVTRYSDRIAYMASNKSNKLEMIHETKFLLERFINRKALNFTASKEQCTSLYLLPATVAPVVTLNDKFIYEAVVTVSKEICSSLFEVREKLLSRQDAAVVEEAKSMVKDLMKWLNWSTWKECGKCDWDEVCFVAIWPWGTQEDHDHPNCRKIDRWWPTVDYWDVDFGEYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF20</accession>
    <name>A0A0B1PF20_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000208">
        <property type="protein sequence ID" value="KHJ35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF20"/>
    <dbReference type="STRING" id="52586.A0A0B1PF20"/>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="OMA" id="VCHACKE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="42390" checksum="184E8D793C51CF9A" modified="2015-03-04" version="1">MHLRSETSPISQVRKKPVSPTTPKITKQIEENRLKAKAIREKFLATESSQNATYTPSGFLIEKNTIGAKRKSPPGSSSIPATSRDARYISHDEGIQPSRKYKKYVDHDFSKMIDTKGGFLNAEDDPWNKAMNHRIDTEKPAHMTLKQWERHQLLKDLRKRKEGLYEPGIGLNAREQGKKCRECGSLEIDWYWEEVFKCAVCSKCKETLPEKYSLLTKTEAKDDYLLTDPELKDTELLPHLSKPNPHKSHWHDMMLFLRYQVEEYAFNQKWGSADALDAEFERREAEKKARKEEKFKSKLRELKKKTRSEAFRRNNQMAKVGAQFGDQIGGQGRHEHRWSQTIQNVDGNTVKVCIDCGMEIEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFP7</accession>
    <name>A0A0B1PFP7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFP7"/>
    <dbReference type="HOGENOM" id="CLU_2777776_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7918" checksum="46B14CC184C7BABA" modified="2015-03-04" version="1">MTGTQERRLKDLCVERGWYLARFSQEFLDDQYRYSVVVGGRIFRGVWSNSESDAKESAAKKACQTFSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG98</accession>
    <name>A0A0B1PG98_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative wd repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000211">
        <property type="protein sequence ID" value="KHJ35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG98"/>
    <dbReference type="STRING" id="52586.A0A0B1PG98"/>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="OMA" id="YEPTGHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="5">
        <location>
            <begin position="485"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="4">
        <location>
            <begin position="870"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="959" mass="108902" checksum="BEC71CF70A289F06" modified="2015-03-04" version="1">MERNDGIVRWSPNQTRDEFIKINVNNGVISLYEATGHAHPGNFDYSCISKHSSFLTISGYDWSPIVQGLVGVGTRQGEIHLLRTDDNSNSKLTLPLKIPRTCQAFAFNTTGLLAVGLDRVRHDAGLQIWDVNERLGAWGSNKPGWIVPSLNLEPHRRLEASMSVTSIRFFEDSPQTLICGVRNQALKIYDLRDPNITAISFHTRCNNNIAIDYLDTNYFASSTLDLPGLVIFDKRASCDRTAASYKYIEAYEEEKLPWGAVLKLDCIIESDCSTSVKQLRFSREHRGTLGVLSTSGQLQILETKKEYNDHNSESTRKSPELLEIRKSYELERSRSNFYSKKRFEQRIVSFDWIYLGTLDLEARIIGLQANGDFKIFKMPSTTTANLLQMIPWAQPHESGDSHLTLPKFNNPREHEEILGPLHASIVESEVPIFGLNRYGTLKTRVELACRIKASIKSLDKIVVHRLSKQCEHKDSDMIGLATAGYLFNCQKNKLLSKSRTQLQDVWEWISGAEEAAKNDGMVTGPLDLSYMGAYCIWTNQLGKKLKSRLKNTATKLDQKQWEYFIAKLNRKNNHFDFDKTETARPHHRILCLAICDCLRTEYEVLEEIETLVAMGDLAKAAGIALLEEKPKLSVEILKYAGSEYLFLAMALEMKIKTDTSLLTPVSDWKQALDNESSLKNNPYIRAIYRFVSIGSWESVAEERQLPMRRRLAIALRYFADEQLTEWLESEMQESIDTGDIEGIILSGITDPAVSVLAKYVEISGDFQTAILVLSFCYPRYLENVCCDAWRDAYRAFLNRHKRFIDRVKFDQASIKKSRDRDGNPIFKPSPRQVTIRCLNCEKTTANDLLTSNTWDSASSFTTGNPLINAGINAGFKCPRCGVSLPRCAVCLHHVLGKPQSENPELLKNPTSSESAINFPSFCMKCRHVMHLEHAILWFSKHEECPIAECQCRCNDMNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGB6</accession>
    <name>A0A0B1PGB6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000204">
        <property type="protein sequence ID" value="KHJ35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGB6"/>
    <dbReference type="HOGENOM" id="CLU_038406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="418" mass="47616" checksum="442A4629E44FA43E" modified="2015-03-04" version="1">MVAGDEKPLAKLSAKSTADPIIRNALRYTISVKEYETLHRYVLSRSRIVKKNVPSVTAFEDFVGVKENDERENIHSNSEKGIDWLITRDEYNVATIRESVRVLLGTTVGLKLWNTIKRILGMRMERKCAYGEFILKNSPAYVQNRPDEYPTFLPWPSKYDVINSLAAMSQQKYPKFISPILFPESKPNFPSIAPITNTAHPLITQLSCAAIHPLDHSCLRTYLKNWITVFPQLTRFFTLIFSVLALPRIILHLNKPDSILNVPQAVIGRLIDRILRYSVFVSGAVGTTWASVCLFQSIFSRSFLTETRFFLGGFLGGLWAWTVRRQARSEFIYSLRASILSCWQLGRKRGWWKSLPGGDVLVFIVCLATLNVVFECDRGRGVVNSWMVRSALSGARGYGWNGIKIEEKPKEQLKYETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGM0</accession>
    <name>A0A0B1PGM0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGM0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGM0"/>
    <dbReference type="HOGENOM" id="CLU_005482_2_0_1"/>
    <dbReference type="OMA" id="DTMFAYA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059629" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="11">
        <location>
            <begin position="178"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="507"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="866" mass="94814" checksum="2F6494384376AA61" modified="2015-03-04" version="1">MKLFQSLILILAVCIQAKPLEGLNCEKPCLLTSPKAQVSSSPTLFSRVLSIDNKDEDNSFIGLTVPSENSTPITSAVLPEVSLRIKKVTPEIVRILPPVATMPALAKEQSTYKLDMNGHTTKSPLIQTSIPVPPANLEPLLGIMQTMKLLKRTSVSQNIFQPVATSAPPSVFSSRPDHPVPRTGIKPQKDPLQTNKFYASFFLGNQTARTWTHPYSVAWAKGEKNVSSWGMSIMHLDANAKVFDQSTNPPRYFLNPLGILSIIVSSSELSSTTYLSIDSLTSTSANVNLHPNSNAPPQITFPLVQGMGFVTAIFHNATPILQSTVLFRNITKSTTAPKSGVSKFKITLEDSNIWFLYAYSSSGAKLEFQSVSNQLLQATTKFDGILQIAKNPPSNVSAEKIYDTTCGAYATSVNLTGSVNGDSGSYTFSFIKGGMPNTTLAMFALPHHVSSFSPDTSNKVTDVQLETTTKGKATAVIADSWTMIEKLPTSLEFKPWNPQAPNEKKALSANAVNSISKVANVEISQDMANQTNLDSVYYSGKALAKFASIAYTLKELLGDEGMAQAGLKNLKSSFSIFTSNKNKYPLVYETAWKGIVSTATYTNGDKGLDFGNTCYNDHHFHYGYFILAAALIGSIDPSWAQANKDYINTLVRDIANPSSADTYFPVSRCFDWYHGHSWAHGLFETYDGKDQESSSEDSMSAYALKMWGKVIGDANLEARGNLQLAINARSLQNYYLFEKTNKVEPANFIGNKVAGILFENKIDHITYFGAEKEYIQGIHMIPILPSSALTRTRTFVQEEWETYFSNGRADAVKGGWKGILYANLALIDPKTAWNYFNSANFDMSTIDGGASRTWYMAFAAGLGGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGS5</accession>
    <name>A0A0B1PGS5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pre-mrna-processing factor 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000290">
        <property type="protein sequence ID" value="KHJ35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGS5"/>
    <dbReference type="STRING" id="52586.A0A0B1PGS5"/>
    <dbReference type="HOGENOM" id="CLU_007434_3_1_1"/>
    <dbReference type="OMA" id="IISWANL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="595" mass="70175" checksum="F8524463A93FE08C" modified="2015-03-04" version="1">MGEFNYGGTEEESAKIKKLNDEVLEDIDNFDNWEKLVCAVESLEGGLNRNSSPQAIATTRDAYDRFLAKFPLLFGYWKKYADLEFSIAGTEAAEMVFERGVASITTSVDLWTDYCAFKVETCHDPDVIRELFERSANSVGLDFLAHPFWDKYLEFEDRLEASDRIFAILHRVIKIPMHQYARYFERFRQLAHTRPLQELVPIETLAQYRAEVESDGFQTGPKGELEIEREVRLKIDNRHLEIFTLTQVETTKRWTYEAEIKRPYFHVTELDNQQLMNWRKYLDFEEAEGDYTRCVFLYERCLVTCAFYDEFWFRYVRWMSAQPEKQEEVRNIYQRASTFYVPISRPGIRLQYAYFEEMSGRVDVARDIHDAILDRMLGHVETILSWANLERRQHGLDSAIRVYQNQIDNPEIDIFAKAAFVVEWAILLWKIKGSPEEARLVFQNNQQWYLHSRHFWMKYLEFELAQPTSTVEEEKHYAIIKQVHQDMLQKTKMSLATKRELSSVYLMYLQQRGTKEAMKEFLQIDKELNGPVSIQPSYLQTKLGSIRIPNKVLENGQLPGEVDEETLRKGEAKYTSYFQEPRIPQINPQALAPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH85</accession>
    <name>A0A0B1PH85_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000221">
        <property type="protein sequence ID" value="KHJ35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PH85"/>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1105"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1412" mass="162387" checksum="A8A5831DCD1F8697" modified="2015-03-04" version="1">MSKHNLVINEAELDDEENDDSFDEETGESRSQNEQMNRVLDDSSEEEDDDDEEAARAVREGFIIDDEDEEPDERERRRRKDKKRRRAEREEAEAALDEEDLDLIGEANPEYKRKILPAQPKLKRLKRGHRDGGEKRLARGLDQIFSDDEELDGPPINESRFNRSNNNRMDEFADFIEEDELEDEDERQRHQEEMEVARPRDKGYIGNPEAAGLDKDALEDMEAIFGNGEDYDWALALEDEAEGVESGDRNLELKDVFEPSQLSEKLLTDADNAIRWADEPERFQLDRMAYKHITITEEQFKEENRWITSLIWPKKQLPSDLQAPFTKAIGKVLEFFVVDEVEVPYVFQHRKDYLIHATRILVRGKIDSEQDEYNVSARKLLNQDDLWRILELDLKFRALVEKRNAILDTYKNLQTKAGIEDKIIEEMIPAAATMEELQDVQDYIHFEYAIEIKDITSSGNMKEKRRPSSKPSIYNRIRKSKAYRLVKAYGITPNQVAQNALREGRKQYTEDASETPIELADSLLVDSEFNTGEQILNAARQMYAEELFTSPRMRKHFRMSYYMMGVVNCSRTEKGLRKIDEQHPYYELKYLQNQTFSDIANKPEIFLKMLKAEEEGLIEVKVLLQHERDFRKQLFAEFASDNFSELADAWNDERQKVLDLAFVKLERVITKGVKESMRTECQDSILKICREEYSRKLDQAPYQPPGMTLGTIPRVLALSNGNGDPGRDAVCWAWVEEDGRAVDNGKINDIFRNEKDRQKFVDIVQRRKPDVIGVSGFSTETLKLANVLRDIISEKGLRAAEFDDRETGEDSGKLLEVVIVNDEVARLFKDSPRATSEHPGLPPLTRYCVALAKYMQNPMKEYAALGKDIVSLSFHPCQQLLPEEKLRKHLDTAIVDMVNLCGVDINEATTDPYTANLLPYVCGLGPRKASAVLKTISNNGGVVYTRDELVGDLDQQKLPVVGPRVWNNCASFLMIVYDSSNAISDYLDNTRVHPEDYELGRKMAADALELDEEDVKAEVDEGGPGAIVRKLIKEDEQEKVNDLILEEYAEQLERNYNQRKRATLETIRAELLQPYEELRKDFVILSSEEIFTMLTGETKESLHEGMIVPINIRVAKEEFIIAKLDCGLEGRVEALEGSDTGMPLNRLFSVGQTTQAKILEIDRTNFIARLSLRQDALRTPFRKRVDRDHGTWDVTQENKDKEELQEKDKATGRTRRVVKHPLFRPFNSTQAEEYLGSQMPGDVVIRSSSKGNDHLAVTWKVADGVYQHIDVLEIQKENEFSVGRQLKIGGKYTYSDLDELIVDHVKAMAKKVDEMKTHEKFQGGSKADTEKWLTTYTEANPKRSVYAFCLDPRHPGYFFLCFKAGQAARVNAWPVRIVPNAFELMKNPYPDMKALCNGFKLRHITRARNDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHC0</accession>
    <name>A0A0B1PHC0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutamine repeat protein-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000105">
        <property type="protein sequence ID" value="KHJ36226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHC0"/>
    <dbReference type="STRING" id="52586.A0A0B1PHC0"/>
    <dbReference type="HOGENOM" id="CLU_047301_0_0_1"/>
    <dbReference type="OMA" id="PPCPAYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="51704" checksum="D869376B93675E30" modified="2015-03-04" version="1">MYAPSYGYVPGNVFNTSAIPSQSQTPLHQQNGHHQHQHQHQQQQQQQQQHSVFSSQQYGDPVAPPPLISYNSAGNTGTLAMVPNSGIAHIGSGNAVPSYQTPYSSSPYSGGIHTPSPSMAQNFTHGSNVLPNYGMNIASPRSQNQTSRLQPSLNSPTLTQHASRAPPFASGQQNTSPNSGSIQTHLPTPQNYNQHFPSNLNAQQVKPAPAIKPQTTNFPPRLQNTTGQSTIALPVNHESDIREKERVTLLLNINRQLLLEVMRLQAAQQDIKDEQNNRPITDGVERAKGPISSRYHFECMRRLQANLAYLAARADRNKNHNILSHPQIMSAPTASPTTTQKKMLNITSPNLDVSIEDDEKRIIKGEDRSELIKAYYNKLQSLFPNVDPKKDSILNPIGRAAQIQKQNSVDSGAQQKAQGEIYRAKIMNPQHISHQQQMLYQQQYQPQQYQPQQYQQQQYHQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHS7</accession>
    <name>A0A0B1PHS7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g6237</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHS7"/>
    <dbReference type="STRING" id="52586.A0A0B1PHS7"/>
    <dbReference type="HOGENOM" id="CLU_042529_2_0_1"/>
    <dbReference type="OMA" id="RSYWIFV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0477">Merozoite</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="264" mass="28258" checksum="A7F21CAFC0253E8E" modified="2015-03-04" version="1">MPSVLRKRKSPAAQPAAAEPIIKKKKKSDSVRPRTNAKKSVAPPLPDKTYDKTSDEERAKNVKVKSLTRSQKVAVGDTITLEGFGGEVETHEGEKTTLLKLANESKKGVVLFTYPKASTPGCTTQACLFRDQYDFLTSTGFSIYGLSKDSNKANTNFKTKQKLPYTLLCDPSAALIKAIGLSKAPSGITRGIFIIDKSGKVLAAQAGNPVTTVNVVKNLVESDSSEIVDETSAEISNDIEKSNESNNADEANSKSTGTADEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHW9</accession>
    <name>A0A0B1PHW9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000041">
        <property type="protein sequence ID" value="KHJ36386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHW9"/>
    <dbReference type="STRING" id="52586.A0A0B1PHW9"/>
    <dbReference type="HOGENOM" id="CLU_021000_0_0_1"/>
    <dbReference type="OMA" id="EPQLAIF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="479" mass="53268" checksum="43839D522DB01246" modified="2015-03-04" version="1">MAPPIVAAKATVSIPLYTCDFDPLEPSRLVIGGGGGASRTGVGNKIIIYDASQPRDLKIVAELELSKNEDNPTSLAVGKNHLIYAGINSSPKEIEKGRNRHFRVYEIQSTDGEEKRDEDVESSELKIFERSTCSLFSGKDEDIYQRITRLATAYPEYQSQLGVVTTGLAQKHEIIIFETKGSNPPSVRDTLRIEKEAVDVDIFQIDDKNFIFAYCDENNIYTKRIGPQLENEQLQCIYKIQPPTNKMKAKISCLRSIRWLVENHIIALTNLHGNSGVTLSIIKCSLERAARRQVINFFRLPRRLKKATGLCLTNLTYENRDKVQGFTQFVLAVAGHDRSIFLFTVDAKFCAGKYIFSAITPFCTFQNVHPLQITSLAFSGICSVDSPTKSNLKPLKLCLASVGISNTVVVHTIPLIPINSPVKNGQKKSICYVVALPSRKKVKIILFGISFMAVLLISILLQGLLNKSSGTPKRLDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIM7</accession>
    <name>A0A0B1PIM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mg(2+) transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000079">
        <property type="protein sequence ID" value="KHJ36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIM7"/>
    <dbReference type="STRING" id="52586.A0A0B1PIM7"/>
    <dbReference type="HOGENOM" id="CLU_007127_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="652" mass="74144" checksum="C3BD820F48475C98" modified="2015-03-04" version="1">MLQFNNDSFKTGSNNTNSQQRENTISPNSLAPKQRNKVDNSDMMKTSNLPKLQTQGLDGNRKETISILPRGQEPRAYEEVVILEVDDGRASRTSKSRRGTFTNYDLRSDSPPNSVKAFADARRRERALSCSDPNVTKAMTESRRHDEYDLNTAISRAMSRESRRSFRSRRSKRIVKEQEDQNEEENEDVLSTRESLRLAVDDVCFPLSATGNKDALRIDFEILENLISDTEDHDKDSATSHSEARVFHDLRHHSHKDNTVHFTYSGEALEAPPFNSEPVSEKVSFNESFKSVKGDQERPVENRFEFFSSLGESTIHAPEFGDLVLPGEDVRALFTLPQDDDIDGVWWLNMNNPTKKEIRTICQAFGVHPLTIEDIVTQEAHEKIELFPSYYFACFRSFHVDNIDGGPQYVPFNIYVIVFREGTLSSSFYPNPHATHVRKRITLLKDYVALSSDWICYALIDNIVDSFAPVISKIEAETDDIEDEVFIARNDDMIPFLRKIGRVRKNVMGLMKLLGGKADVLKGFTKRCNADYKVTPRMDIGLYLGDIQDHVVTMMASLIHFEKMLSRAHSNYLAQLSIDNITQGNHANNVLSKITLLASILVPLNLVCGMFGMNVKVPWRDTDSLAPFFGILGLLLFLTIISLYAARRMRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUK1</accession>
    <name>A0A0B1NUK1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005473">
        <property type="protein sequence ID" value="KHJ30047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUK1"/>
    <dbReference type="HOGENOM" id="CLU_1251484_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="24964" checksum="D913F88838BF36AC" modified="2015-03-04" version="1">MVLFSKLPRVGFRVFNKSGIARPLKKQQPLEFCKKSNGHHPSKNCFKEPSCGNCGSTNHTEELCTAFPTTVRPLLDWTFTYLAFNNISETMAWACSEECMTSDHLLICGFVRNHKASTSNSPTSNGKLRVSKANLPQFARVVAQLLPSYRPISTAEEIDEFTQDINLALGNALKAVGKQPNEKSGKSAPWWMANVDLLIWTTEMHYRYLSVVKRREYSELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVJ5</accession>
    <name>A0A0B1NVJ5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004432">
        <property type="protein sequence ID" value="KHJ30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVJ5"/>
    <dbReference type="STRING" id="52586.A0A0B1NVJ5"/>
    <dbReference type="HOGENOM" id="CLU_101493_1_0_1"/>
    <dbReference type="OMA" id="RMYGKMP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="15507" checksum="3397E8146177BD23" modified="2015-03-04" version="1">MNPYQMKKVDVSSMTPDEQRLFRLYGKLPSTSDHLSKHLKERKYFDSGDYALSKAGKASSVDTGSVGSEHPVPENIPHLSSPIMGSAHQGIPPINSNHYGTATSGIQNRSPVKESSFLNRETSLDEQSTKEDQERDKGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVU7</accession>
    <name>A0A0B1NVU7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005158">
        <property type="protein sequence ID" value="KHJ30098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVU7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVU7"/>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="405" mass="46477" checksum="25CF968CF2B60CB9" modified="2015-03-04" version="1">MDQRMAFSWVQKHIKKFGGDKSRVTLVGEGAGASSILHHLTAPNITNRFFPMIQSKSHHHRKFPFRSAVLQSPKYQPIITSQSDIIFEKACRPRIATIHSFSPHLILQSAYIVKVLTVTTAIWGHKVKNIAKLRLLPYEVLYAVNAALIQESSYGTFTFGPAVDYQKGIDNSYVPDFPLRRLAKGKMAKGVHIIIGQKRNENSFLFPSTVLKDDGLKDHLARIFPTVAKHHINYVSDFLYPSRDYEDMENFEVRRSTEVLYDVFVGCNFHYLLQEMARSSGYILDTTWAIQERFFEQAFFQGKARDSLGKFLPNTSAHWLQEEILQFSREGASTSKIRPYDGSGKVLLASDGKPKDYIDDPTAKHLCQYWADFRYEDRKCYKMYKVNIANLCCDSGSLIWVRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW24</accession>
    <name>A0A0B1NW24_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003938">
        <property type="protein sequence ID" value="KHJ30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW24"/>
    <dbReference type="STRING" id="52586.A0A0B1NW24"/>
    <dbReference type="HOGENOM" id="CLU_750451_0_0_1"/>
    <dbReference type="OMA" id="FVEWAAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="183"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="442" mass="49436" checksum="C9D693FA182CA259" modified="2015-03-04" version="1">MNTISLLQSESDEALAAAVLEVFREFGTVFVKIRRDAKHMPFAFCQYTNDENAELAIKDGRGRLIKGRPCRCEKAKAHRLFFFERKNGITVTPDEVRNLLRNFGKLTECRPATHLEMVTNNLGEGVVVNFDMFESGKNACQAFRNHAIYNMISLFHLGTSQDDRRPTDLTHRSCLDTYEVDRRSIFVGNLPTEINDLEVKNIFSKYGEIIDVTIYKNESNFDPSSKHCFAFVQFSSQPSVEKAITELNCSLLQGKTIRVSQKDSEIARSRARSRHQTSRPQGSNIASTYQTSTVAPQTLSSPIPFSTPFPACQSQFGGFGSTTNSYANSCYLDPRGQYWITPSPPYSYSYSSPFQISPFPNSQYQTGPFYGYSSSPHGLYSCNWHQTLAPVCNAPGLPSMVSTISPQPYPQSISGTIAQNQSYLASNTNGHTIVDSSMEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW94</accession>
    <name>A0A0B1NW94_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative karyopherin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5586</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003793">
        <property type="protein sequence ID" value="KHJ30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW94"/>
    <dbReference type="STRING" id="52586.A0A0B1NW94"/>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="OMA" id="ANACGCV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123200" checksum="C517CE358E80B1EF" modified="2015-03-04" version="1">MDQQRFLELLKEVQIPNTQRVKAATSELRKNYYTQPESLLYLLHFLTSNEASEIRQLAAVGATRLVDQHWSTLNDEQKSTFRERLLQCVLEEQKSTIRNLLSRVVAAIANLDFKQGQWTQLPSWLAQAATSEKTRHRETGLYIIYTLLEDAFEIFEDKLPDLFQLLNTTIKDPESAEARINSLLCLSWVAIMLEPDEHKASFDCFNDIFPQMVNVLKVAIQEDHEGHIMQAFEVFQTLLSCEPSLLNKHFKDLLNFMIEISSNTNISSETRCQALSFLMQATKFRKMKIQGLKDMGETITLKSMQIASEIDDTLPEDDDDVTPSKSALGLLDLLASSLPPRQVIIPLLKVLPEYVKNSNPKYRQAGILALGMCVEGAPDFICSQLDTLMPSILQLLHDSDISVRRAALNGVSRLADDLAEDLSKHHEQLIPILLKNLDSAGCLSDSSEAEVSKNLDILKSSCGAIDSVCRGISKISIRNYITELVPRLGNLLSHSDLTVKSSAAGALGSIAESSEDAFLPYFETSMGALSQFLSIKDTSEELDLRGVVCDAVGCIATAVGPEVFKPYVNILMQTSEENLHLDHPRLRETSYILWSTFAKLYEADFSPFLEGVVKSIFKSLTQDESELSGELGEGKQELLGQKVIVSDNKVQFSPKSNFDTEIDNMDDDNESDWDDDFANTAVAMEKEVAIEVLGDVMSHTRRNFMPYFEQAVKITLDLIEHGYDGLRKGAIGTLWRSYACLWALMEDETGEKWTPGLPLKQKPSGELLKLGELVTTATVSLWEDETNRAVVTDINRNVAATLKLCGPAILTQKDFTEKTITICTALITKLHPCQRDLGDDADNSGLADEESSEYDWLVIDTAFDVIISLSKAIGSQFGELWKIFQKPIMKFASSQVNYERSAAVGVIAECIGNMGDSVTPYTKTLLTLLLHRLDDEDGETKSNAAFAIGQLVFHSTASSEYLSAFTTIFNKLEPLLNTQHSRSKDNAVGCICRMIMSEIDHVPIQEVLPAIIDLLPLKEDYEENSPLFDCISGLYNQAHPLILSQTAKLIPIFASVLGEPYNQLESPTRSKIIASIKFIAEKDPTLVHGNENLVKVLQENINQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWA1</accession>
    <name>A0A0B1NWA1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative krab-a domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004666">
        <property type="protein sequence ID" value="KHJ30243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWA1"/>
    <dbReference type="STRING" id="52586.A0A0B1NWA1"/>
    <dbReference type="HOGENOM" id="CLU_2016906_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="123" mass="14359" checksum="BD6A96CA2DB31324" modified="2015-03-04" version="1">MKADITWHRANPLISSKYTLIYETKFPELFNKSLRRTEELSKTTHQIDTGEHSPIKLPPRRYSPSQQEAIRDFCKAHQGTLIRKSKGPWAAPLLLTPKKTPSQSNKIIWRICVDYRELNKITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWI5</accession>
    <name>A0A0B1NWI5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cue domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004561">
        <property type="protein sequence ID" value="KHJ30293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWI5"/>
    <dbReference type="STRING" id="52586.A0A0B1NWI5"/>
    <dbReference type="HOGENOM" id="CLU_040954_0_0_1"/>
    <dbReference type="OMA" id="RRSADHN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="420" mass="46485" checksum="1276086755D9EDAB" modified="2015-03-04" version="1">MSNHSRNEAKLDSPFKHCHGAESPTTVKPFDMDDDEIPEPAVGVIEAPNSSETIKMNDNPPNQPLQQPPQIINHDVKAEDTLKDAFPSIDIAVIKAVLRASGGQIEPAFNALLGMSDPEATQDLSNPPTSFHSTANNGAGSTPLSQLEADERYARQLANQYQYQYNDARENLGSMRNNPRRNLAPTPDRRQNIYEERSFLEDDLPIIKDNLKKGFLETQNKVSNWITFLKKKIDGDDDADSVHQNYGSTSRLNRFKDDGRKSDDFSPYDADPQVLSDDFAGIQLHSDGTLASQSNKADKSQLKSNPVSSKNSYGYQALGVVSPSKINETYTINSNTEDKSTVKQSKWQPLSTVDSSNINDADNDPFSLGDTDDEKDVRDRAPDKEVKPSLAEAHDKSMTGIKNNKIVESESNCINTPIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX94</accession>
    <name>A0A0B1NX94_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003895">
        <property type="protein sequence ID" value="KHJ30603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX94"/>
    <dbReference type="HOGENOM" id="CLU_1866628_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15742" checksum="66E975DDCBD34FEB" modified="2015-03-04" version="1">MAVDQDCDTIMSGTNAILAAIENLKIQTQVGKAKPTRGKKGKSKTSPPQKKSKEPLKPRAPWRSLTEFNRKVEREACIRCKKEGHKGEACPTYREARWPKENLSQLEEESGENEEEDLLWIQIREKIIPEQSRARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXZ9</accession>
    <name>A0A0B1NXZ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003068">
        <property type="protein sequence ID" value="KHJ31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXZ9"/>
    <dbReference type="HOGENOM" id="CLU_970421_0_0_1"/>
    <dbReference type="OMA" id="NNGNFPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="30928" checksum="C244A8E0F738E229" modified="2015-03-04" version="1">MIQNLTFAQVLSQCPGGPTNNGLSATQPLQSNFQNNGNINGGNFPNNGNIINGNFQNGNFPNNGNFPNGNFQNGNFPNNGNFPNGNFQNGNFPNNGNFPNNGNFPNNGNFPNGNFQNGGNFPNNGNFPNGNFQNNGNFPNGNFPNNGNFPNNGNFPNGNFQNGNFQNGNFPNNGNFPNNGNFPNGNFQNGNFQNGNFPNNGNFPNGNFQNNGIFPNGGNFQNNGNFQNGVNVLSVESEPTDEPEKNENETELVSNEPQNGEKESSESQIESSKEPQIEETVEASPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYC7</accession>
    <name>A0A0B1NYC7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005505">
        <property type="protein sequence ID" value="KHJ30040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYC7"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_2_1"/>
    <dbReference type="OMA" id="LIQIEGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="81" mass="9372" checksum="D4F99CE054F845C4" modified="2015-03-04" version="1">MVKLGSTKEKRLMIDIMAIRQSYERRELSEIRWINGNDNPADAMTKANATKALKSLIENGELLIQIEGWVQREKEKMPVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZJ0</accession>
    <name>A0A0B1NZJ0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004211">
        <property type="protein sequence ID" value="KHJ30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZJ0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZJ0"/>
    <dbReference type="HOGENOM" id="CLU_047291_0_0_1"/>
    <dbReference type="OMA" id="AWGKSAM"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="6">
        <location>
            <begin position="243"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39964" checksum="152ED48996A986DA" modified="2015-03-04" version="1">MPAPQDSPGLKSSNSKIGLKSFSLASKPSQQKSFHLKNSPFEKRSQSLFLNQEDSDLQTDLGHRFSVEDVTGFGEDGAFKDEDQTKGLLVIKRLKNKDWKSELRRRRKANDLLHQERRAETICTNSGGTKINETQKIEGVNVINSDDSNIEWGLSFRKRSGIDQNTQMKETEETENYKKNMQEDILNSRPEPQDLDEEALQALVGSNKQCEMSHLIISAQNTPSRLEVISEQEAYKLAIASAPEPSTLEDYERVPVEEFGSALLRGMGWNGEKVGGIKKVKPRQNLLGLGAKELKDAEELGAWVNKSDTKRLNSSRGGDRSDKSHGRLKPADYKREEEKRRKKRDERGGGSYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZL8</accession>
    <name>A0A0B1NZL8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine aminotransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glutamate pyruvate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamate pyruvate transaminase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamic--alanine transaminase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Glutamic--pyruvic transaminase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g5188</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004128">
        <property type="protein sequence ID" value="KHJ30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZL8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZL8"/>
    <dbReference type="HOGENOM" id="CLU_014254_3_0_1"/>
    <dbReference type="OMA" id="AYMARTM"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000140">
        <property type="entry name" value="alanine aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000236">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 20" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="104"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ30490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="484" mass="54339" checksum="A767EE1B3E744DEC" modified="2015-03-04" version="1">MTSSLNCLATENINSHDKDVRFNFQGDFDSHPREYRAGLPNNDNFLPFNQNICANVGNPQKLGQKPITFFRQVLSLLQYPHLLENQDVLLNKLGYKLDVLERAKILLKAIGSLGAYTATNGIPQVRKSIAKFLEKRDGHPAEPADIYLSSGASSAMVNLLNVICDKPATGVLVPFPQFPLQTAMVSRLGSKLVPYYISGPRNSETDFEAIKSAYKIAKKTGTDVRAMVIINPGNLTSKCFSVEDIEAIIDLAATERLVIITDEAYQNNIFEDKFYSFKRVLRDLQNLYPNKYDNVELASIHSVSMGMVGEGGQRGGFFELVGFDPAVQFQIYKLLSFTNYCPSIAQCLIELMVNPPQEDSASYELYEKEYCSIFVDLKEKSFALYEVLKQMEGVECSEPQGSMYLFPYFKLPTKLVEAAKKEGRSPCEFYASSLFEATGICVVPSLGFGQEEGTLHFRATPLAFDTDWMSVLQKFHNEFLKKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZT5</accession>
    <name>A0A0B1NZT5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005165">
        <property type="protein sequence ID" value="KHJ30094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZT5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZT5"/>
    <dbReference type="HOGENOM" id="CLU_139931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="15267" checksum="3F745EBD64304730" modified="2015-03-04" version="1">MAHHSGSWEIEKLTKENHEKWFRLMKAKFQSKGVSYILEFSLEDHARIAEPHSPNANSDEELEKVRDSIDKINLNKSKGGSSSHKKQVLNIEKKKEYMRDEGTLKFILLQGLDDDDQALLDDCTIHKGFEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P060</accession>
    <name>A0A0B1P060_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003774">
        <property type="protein sequence ID" value="KHJ30675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P060"/>
    <dbReference type="STRING" id="52586.A0A0B1P060"/>
    <dbReference type="HOGENOM" id="CLU_047729_3_2_1"/>
    <dbReference type="OMA" id="GMQCTGT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080405" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="211" mass="20947" checksum="1FC43928F52C0FAE" modified="2015-03-04" version="1">MLFKSVLAFFAAAQLVAGHGAIVKAVGDMGGNGSAIGIDASTPRDGTRRTPFQADSTRFKNVNPDACGETLGGGPNDPTSQVAKVAQDSNGLPMVSAGGMIMMTLHQVNGDGAGPYSCMIDSTGTGTGGWTKMEVATNVPGKNSRSKAKATDFPLSAKIAADQTCTGSMGGMDNVCMVRCNNAANAGPFGGCVPVQMVGAGAGAGAAAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T7</accession>
    <name>A0A0B1P0T7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">EV44_g1045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01004045">
        <property type="protein sequence ID" value="KHJ30536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T7"/>
    <dbReference type="SMR" id="A0A0B1P0T7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0T7"/>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="OMA" id="WFPGTSG"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27814" checksum="B5CC54EA26AE6D30" modified="2015-03-04" version="1">MEDNNDHLVRSSDDQHPANLIPELCRKFWTLGWVTGTGGGASIRKDDLVYLAPSGVQKELMRPENIYVLEMSKQIDPKKRIYLRSPQNLKPSQCTPLFMAAFKKRNAGCCIHTHSQWAVLITLLLERRTENCKVFEINNIEQIKAFGRGWQKQGALGYHDTLRVPVIENTPFEEDLTEYLESAMDDFPDTYAVLVRRHGLYVWGETVNKAKQQAESLDYLFQLAVEMEKLNLPWLSDICPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P108</accession>
    <name>A0A0B1P108_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0687</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003384">
        <property type="protein sequence ID" value="KHJ30980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P108"/>
    <dbReference type="STRING" id="52586.A0A0B1P108"/>
    <dbReference type="HOGENOM" id="CLU_012062_14_5_1"/>
    <dbReference type="OMA" id="CKNFLQH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="557" mass="62394" checksum="23FA7DB24FFE42DB" modified="2015-03-04" version="1">MSSLYNLEPQPTASCILHTTAGDIALELWASQLPLTCRNFLQHCIDGYYDNTIFHRLVPKFIIQGGDPTGTGNGGESIYDGGAYAKSREEGGIWPMEDRKGKNAGPNGIGFKDEFHSRIKFNRRGLLGMANDGPDSNGSQFFITLDSTPELQGKNTVFGRVQGETIYNVARMGEAEIGEGERPLYPIKITGVEVLVNFFKDMIKRERIAPVVTQVLNLEKKKKKKLDKKLLSFDDGTEDANEMQHVAKKRKYDSRIVADIVDELDPKPYSQTDSKKKIEIRKELDGKEKVNVEKSKISATKESISLESPPNITLEPVLRESSSPEPSKTAPSMVERTNAQIAELKASMKRKIQAVPSSEKKISIFESLIPATSTRGRKRNLGENIPPDPKTLEILKVFQSKLEQTTKLTADPELKSKPLESGSSTIPIKQIANGDEDEAILCDLHFVASCQSCSKWDITHDDGAAVDDLKTELNGTSWMFHTLKFKEDKLGKDLSYRKKAEEELVVIDPREKARSFKEEVKARREARSIGGTKREWDNHKSINFNRTSNHLNGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P124</accession>
    <name>A0A0B1P124_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4892</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01004054">
        <property type="protein sequence ID" value="KHJ30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P124"/>
    <dbReference type="STRING" id="52586.A0A0B1P124"/>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="489" mass="54937" checksum="C840BB5FD4D91634" modified="2015-03-04" version="1">MAPSSQKFELKTPKGTKDWQGKDMVIRESIFSAITDVFKRHGAVTIDTPVFELKDILSGKYGEDSKLIYDLADQGGELCSLRYDLTVPFARWLAMNRDIQSIKRYQIGKVYRRDQPAVNKGRMREFYQCDFDIAGTYDPMLPDAEIVRIASEVFNSLGWKGCYLIKLNHRKILDGIFESCGVPHDNIRAISSAIDKLDKAPWEEVRKEMVDQKGLDPKIADKIGEYVVQKGQKDLLSKLMADENMAENKAARAGMEELDLLFNYLEAFNVMDNVSFDLSLARGLDYYTGVIFEIVMVDPICAESNYQTSDNIHGVGSIAAGGRYDNLVGMFSGKNQIPCVGISFGVERIFSIVKSRMTSENNFDYVRKNAVDCYVMAFGGKGFTGLLRERISICTTLWEAGIKAEFLYKIKPKLPNQFKAAEANGVPFCIVIGDDELAEGKVKIKEMGLRDGHPEKEGVLIDLKDIVEQVQQRLQRKGSPKILPVLTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1A3</accession>
    <name>A0A0B1P1A3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002404">
        <property type="protein sequence ID" value="KHJ32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1A3"/>
    <dbReference type="SMR" id="A0A0B1P1A3"/>
    <dbReference type="HOGENOM" id="CLU_1442077_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058814" description="Secreted effector protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21836" checksum="293176442CE7343A" modified="2015-03-04" version="1">MRYFVTGITITLLLSSVSTTLDSDLPRWKNRQKTQSDTDLYSDHHFTSQHAINGYVPSIGFESDGYGISKRSNRKTVHGYYCGSSKHEQHFYEQDYINNAATQACNELGLGSEKKRKNLKPFTATSYQSFQGPYYEYPIRGKHKKKLFAKKKKNKYPNRVVINTQCEIVDVVTNNEDFHYQQCTRGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C3</accession>
    <name>A0A0B1P1C3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002392">
        <property type="protein sequence ID" value="KHJ32033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C3"/>
    <dbReference type="HOGENOM" id="CLU_1864789_0_0_1"/>
    <dbReference type="OMA" id="HLILECN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="152" mass="17878" checksum="C722EFBACEA195C7" modified="2015-03-04" version="1">MNYRGTPYELHRNLSRAQSSIATQVRSEHIGLNSYLYRRKVPGVETPTYWCGYRSQNVKHMIMACPRWAKGRSEILRKAENRFFKAMINNPKGMARITQWILNEGKLEQFRLVGAIETVIKQRGEEKKLRQTWTPHWHVKANVLPKGKLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1E8</accession>
    <name>A0A0B1P1E8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translocation protein sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003246">
        <property type="protein sequence ID" value="KHJ31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1E8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1E8"/>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="OMA" id="KPWFPAH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22892" checksum="338EB114781DA2F2" modified="2015-03-04" version="1">MFNLDWVGLSVPIAYIAVLVGSLVTFSSVYRKRKAAAAASLTPWFPPHVQRDIYLSLLYLEPEEGKSSNFPVPDSLKRAALLRRAVEDIFRIIQIRNTKQACITSLQRGSIGDDLWQIFLRAEKEMEKELEDVVIEANALQSNWGQTIFQSANEIAANTTIRNSLEEIQSHVDSETKWWEKRRKYIQSEFMKELDDAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F5</accession>
    <name>A0A0B1P1F5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tkp3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002074">
        <property type="protein sequence ID" value="KHJ32457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1F5"/>
    <dbReference type="HOGENOM" id="CLU_607195_0_0_1"/>
    <dbReference type="OMA" id="AISACHP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="146"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="451" mass="51235" checksum="7DFC7C7A95E1D071" modified="2015-03-04" version="1">MPEQEQVKDPNQLNRIDLQCIFEFLSHNQDLPSNLDADWINENFGLYGGKLCLLKKNSQRLIGDPPKPPGVAILLEILEYDDMVDAIRLIHINQGHSSIGNTIREASQIYWHPELTLASYEVIRTCPSCQLMKPPDPSLGNLQPIQPAPPLTRWGIDHTQVGPKIILNAIEYATNWLESRLVPSADFSNTVPLLIYIINVFGTPKQIISDNAGCFAGIEAQNFQAKYKLNFTHTTPVRPRSNGKVEQANGVLKSILARTILENRLQPLHSLLAHAVAIYNRRISPSGYSPFFLLFGTKPPEEELIYPIYVREPTPQEEIKWATELAKSHAAPISRSYVNSMRASRAKVREYLQEKKALMRTYVPGDWVLRVRQRRHKFEPFYDGPWAISACHPSNTYSLISPGGYKLINRYNGTNLFPAYSRDGHPVRSLWYGSQRMLDQDRKRIKSAVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q7</accession>
    <name>A0A0B1P1Q7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002264">
        <property type="protein sequence ID" value="KHJ32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q7"/>
    <dbReference type="HOGENOM" id="CLU_858417_0_0_1"/>
    <dbReference type="OMA" id="CETINQP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="106"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="324" mass="36704" checksum="8C7F84621B8A9B1A" modified="2015-03-04" version="1">MSNFGVNILTLITQRTYFLGSKRDAYNIIKQLNYRPVKLKKSQCFYSTPSNTKKYHNTDNLLNISPSECETINQPIIPDRSEIEQKLIMGFEEQVENIPDKVRQIMRYIPQSIAILTTCTIPKLDFYRSTTQVSGYIDDTSHSKGIGMTLSSVSTVTLQPEPIISFNIKKPSNTLEAIKYHGNFLIHFPSCSKAGAILADTFSRGGRYLQSDSHSRKEIRTSFERSTPISVINFDGQNINLPALLPPIYPINYMLKCEIYDRVNGYIDIADHVIVVAKVHKIRCISKSSSSYKSTSNIQERDSCLAYTNGTYCSTRSIFNTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M9</accession>
    <name>A0A0B1P2M9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002751">
        <property type="protein sequence ID" value="KHJ31590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2M9"/>
    <dbReference type="HOGENOM" id="CLU_030577_0_0_1"/>
    <dbReference type="OMA" id="NHVKRAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="109"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PDIA6-like C-terminal thioredoxin-like" evidence="9">
        <location>
            <begin position="209"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="504" mass="56507" checksum="9DFD5F3349DBA1DA" modified="2015-03-04" version="1">MPTYEKVAQRLAGLAKVAAVNCEKESNRHFCDQAGIRGFPTLNIVKPGKTAGKPIVQEYNGARSAKEIVETVIDKIPNFVEKLSEDNVGKWIQDASESPLAILFTNKPRINPLLKALAIEFKGSIKFSHAQVSKDNKDIEKKYEIKKLPTIMLVKRGETDEFLRYDDEMKKDILVEFLSQAAAPNPDPAPLDASKTNAQSTSKNFKTPKPTKTPPTVSPLTVVEKEDDLVKECLGHKTSTCLIAFLPTSPDSIALNLIDVLTQLTHKLKQQKRSIISTFVLPEANPQYAVLRNKLSLEGKADIIAINGKRAWWRHLTDTDFSSKSAIEVSLERWISSIQLGEGEKKKLPFSLVIEESEKILSDDEVEIPIDLIESLDEKKSSEDKESSEEKESSEEKESSEKKESSEEKESSEKKELSEEKESSEENESSEENESSEKKESSEENESLEENESSEEKESSEKKESSEEKESSEEESSSKRGKFSNEETFKNIETKGTGNNHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W1</accession>
    <name>A0A0B1P2W1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003072">
        <property type="protein sequence ID" value="KHJ31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2W1"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_0_1"/>
    <dbReference type="OMA" id="MINITPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33324" checksum="A477F94A72AAA9FC" modified="2015-03-04" version="1">MSQRLILALTAILQEKKSLNLYVRDISQAYVQSSTHLNRDFFVKPPTELQMDEGSILRIVKPLYGIPEAGNHCVCQPESAFDLASAAQVTNPKEEDVKTLNKRLQWQINNKLKGLRFIHLNIHTLRLVVFTDASFANNRDLSSQIGFVITLADDSNKANIIHWSSLKCKRVTRSILASELYAVAHGFDTAIVLKSTIEKILQKNNLPLILCADSKSLYDCLVKLGTTQEKRLMVDLMCIRQSYERRQITEIRWIDGNSNPADAMTKGQPCSALTRLIDTNMINITPFGWVERYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Z1</accession>
    <name>A0A0B1P2Z1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001915">
        <property type="protein sequence ID" value="KHJ32648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Z1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Z1"/>
    <dbReference type="HOGENOM" id="CLU_1485469_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000295">
        <property type="entry name" value="Phosphatidyl synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="185" mass="20056" checksum="353D515C0FCB53A5" modified="2015-03-04" version="1">MGSVKVLPALPDRPFLRRLSSMTTTEDEVKEGGPVVIVPERMMRKNQKQNGCSIAAAIETARKELSNLNIEEEDSISSTSSSKSLPGSPDFPAKISTADSFAFAFDIDGVLIRGGRPIPEAIEAMRVLNGENKYGIKVPYIFLTNGGGKTESERCIDLSRQLDIEVSPSQFICGKLQIPLVLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P328</accession>
    <name>A0A0B1P328_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">EV44_g2856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003271">
        <property type="protein sequence ID" value="KHJ31084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P328"/>
    <dbReference type="STRING" id="52586.A0A0B1P328"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="453" mass="51262" checksum="0BD34EBAE8998B33" modified="2015-03-04" version="1">MSKIMNKSPDSDGLQILQLAEFEISPSTRSWVSVPNPNDHQLIATATSDKLARIYSLEDFSLHSVLEGGHSRSVRSIAWKPTRKKSDPITLVTGSFDATIGIWRYNGKYLDKLTRKQTSGELVENIDELEIDHTYTVNDESKRDDEDWDFAIVLEGHDAEIKDVAYSPSGQYLASCSRDKSIWIWEEVGAEGDDEFETVAVLQDHTADVKCISWRKDDGMGELLASAGYDDTIRFWRDSDGEGEWECVALLEGHSGTIWALEWEPEVSMTKFQPSLQGQEEKGVPRLMSASADLTIRLWCKVASPLPPKRPSYFDATIPSTMRPSPEIETWEVSTILPQIHRFAIYSISWSKNTGRVLSTGADGKIVLYEECFIGRQTENDVLEREWVIIAILGSCHGPYEINHITWCERWNSEKQKKEEIFITTGDDGLVKAWSLQKQTGQAVTYASKYLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P355</accession>
    <name>A0A0B1P355_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4767</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003247">
        <property type="protein sequence ID" value="KHJ31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P355"/>
    <dbReference type="HOGENOM" id="CLU_002803_1_0_1"/>
    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="102"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1271"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="674"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="778"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="862"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1305"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1324"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1364"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1407" mass="160969" checksum="18B1C663CFB3C557" modified="2015-03-04" version="1">MALKVYIAHSGQCLLADTEALRSADDFKAWVSKNSKVVVQNQIHLNTEGKHVKFATLGCENEIFVYDWNLVQSSSPRSVKLRQYDLPIPQSYNISKPPDTISNQNELEAWRDLFKARKDWALNVVSDCQKMSDEVQKRWTEIEVIIRAASTAVRNVQKHIILVDQKKSVIKGWIEDINKIQESSGNDWNRLFDILRAIPVNHEMMIFLSGNGPLAKKNLTLEDYAQNEKFRKARNLVGSIQCQLSRSTVELEKKIDEIYRNSDALINLVSKNMPERSLAIKSLDTIQLLKEIEELAKKITSDCENMCSKDSITLPQASKFALIHTKMLLPSIVKHSMEINSFFQTVTKTRNSLALSSLEAMQQISCLTFTVSEVTSQLTDLEPSEESNEALQTLLDITLLPVTYASFLAEGIRRNRWKEKIETDSSTLINEFKIFQEEELRRRRKWQKAIGVTILGKRVEQNFPELELNIRGIDDNWPKISKQDLEEVFQILQTKDPNSALAKKVSKIFLDLCNPTKQQAKRAKAAFKAGSLHENFLGSSTLLVRGDDELVRILQEEGQKTMSKLRTAESRVRRLENLLHQHTQVNRSTIGYKFQSPSHHSHDSQNPSYQAQSPKSLEDQSRPFSIPRQRSSLNQSSDERLVYQKFFKLEAELISEKERSARFEKEIIERKLTEEKLKTEIDEVNSTKRDLLKNLEAQQREFIVERKSLATEIKRVQAQKEDLENDLDNYVNPRGNENENSSLINVGQTTCDVPLNIPGNFISDDVEREQISDKNFDLLNLEKEKEKLILRANEAEKSVAEYHEILRNLYRQILPHEEIPNKIGPLTQRLTLKQGELILELESVKKDLQAAKCNSDQTHNTLVEVRSELSEVKERLQADESKCYESQKILDESYAKFTALERELSDERLQLSSARKKIIDYEIDLESLKKKLSDEENRSSSMKDSQFTQASRIDFLEKEIEAHRSKNEAFQAQYNLICTKMEDRSSIVMDLTHRFSTQNDQLCKLLERLNYSINRGTKPMVIQRLPKPERPNPNESSELNSAIRRVLPISSVRKSVIESGKLESLNWLPNDDIETEKQKYDSFLNSAGYFDIEVFCETISKRIKDLEYTAKKYSRDARSYREKFQSAQKEAQGKIAFKNFKEGDLALFLPTRNQATGAWAAFNIGAPHYFLKEQDFHKLRSRDWLLARIHKIEDRVVDLSKSLSGPHIHISQQRSCTEASYDGDPYEDDNPFDLSDGLRWYLIDAAEEKPGAPTTPGLGKCTVASANIDATGSIRRSKKSPNSNMEGINRTLSKNLRTRRDSNNSKKSLASASSIIKSNSTSTDTTFLKSNNKTQTAEEGTDINANNSSMKLERARISSESIDKGTTSENISKSPTELGVTNSSRRSIIWDSLWSLDLSIESGKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J1</accession>
    <name>A0A0B1P3J1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003100">
        <property type="protein sequence ID" value="KHJ31234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3J1"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="113" mass="12905" checksum="F41AA1A7EAB25AD4" modified="2015-03-04" version="1">MCHGFDIACVLKNTIDKILDTKVPIIICIDSFSLFECLVKLGTTREKRLMIDITALRQAYERREIAEVIWIMGETNPADALTKHVGNKALQQIIDTNKVDLKPGAWVERYDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3P0</accession>
    <name>A0A0B1P3P0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative msf multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002773">
        <property type="protein sequence ID" value="KHJ31566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3P0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3P0"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_2_1"/>
    <dbReference type="OMA" id="IVTHRIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="63936" checksum="25FBF0E20A30A8FE" modified="2015-03-04" version="1">MPSISLQAVKTEAPPDYRPPSSASWQDEPLKMEKKHNRNASSSPSENDDLAHIVDHDPRTAVRPLSGYHLPIVLFILVFGLFLSTVETSITATALVKIGIYFNDSYTANWVVLSYLLTYMGFSVIFARLSDAIGRKFAILLSWLIFGFFSLASGLSTSLTQLIIFRSFQGIGGSGLFTMAMTVAPQVTPVKYWGLLSGSLGAALACSSLIGPIAGGVITQRFGWRWIYLYNAPCAAMIIIPFLLSWPKDRPHANQSRSLLLTQVDVPGALLLLSASTLLVFALDQGGSYRLNWNSTTIILCLLTSALCGIMFICWIIFVEAGKCRINIKPIFSLKSSLVRPIGPAIALSFMSGFPFFIVMINLPIRFQILNGNSPTMAGVHLMPLLALSATGSCIGGLFSVSKNRTYYTLVFAFVLMCLGTGLLSTIPNSRVISHLQYLYQAILGLGIGLSLSSITVMTGLASNYESIASVNGAVNQARVLGGSIGLSVANIILNNEISNKLTGILTPMELTDLQQSLNTAIKLAPSKQLEVVRVYASSFNSQMRICLYLSIFGFFVSHLTYKRVPASVRAYQAQQEAMNNNDQVNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X6</accession>
    <name>A0A0B1P3X6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002974">
        <property type="protein sequence ID" value="KHJ31344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3X6"/>
    <dbReference type="HOGENOM" id="CLU_2039803_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="121" mass="13602" checksum="882CF492B4209E58" modified="2015-03-04" version="1">MARNILHAVNMMLLSMKAPAHLHLTTMRYNERGNLTGLTTAQTTAEAMILRFKGSILKVVLRFDPDITEITANQQWILLKSHGIELSRYYNDNGLKINKRGVSCKPVRTTAAIYTTLGIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P409</accession>
    <name>A0A0B1P409_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002362">
        <property type="protein sequence ID" value="KHJ32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P409"/>
    <dbReference type="HOGENOM" id="CLU_1310917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="23692" checksum="68D9B4CF18495CB0" modified="2015-03-04" version="1">MFGDLQSTHDQQKTANYWFSEDKRLHEINKNHILQSPQIKQIPPRFEGEQSSWQRHNNQDGQYNNTSLYSSPEIQSKAIPNHQDLRKDLESTKHQSCAPLTPTDGVLSTTTPKEPPSMPKSQKSVDEPPSTPEIPDEIWLCPKNDIIARPSSPTESLQSGADSCITTSTQQNDPKHDDEQEEGEQIDQGEPTVTQLGVHDSALTTRYTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P478</accession>
    <name>A0A0B1P478_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001628">
        <property type="protein sequence ID" value="KHJ33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P478"/>
    <dbReference type="STRING" id="52586.A0A0B1P478"/>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OMA" id="SYFVRWV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="220"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="914"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="994" mass="110428" checksum="8F8185FA92711A33" modified="2015-03-04" version="1">MAGLEKLEIHSKSYIVRWIRAEDGHSISWSIQPHKKSINFGIIKHPGNLGTDFNINLSVEDTSSTSLLEPDIDKSSRSSSTRNDTSTAQEKLKAKGFIIVQWYGKCEADKVFMGTHAVVGYEGMYGLVLDNTFSKQLLKTATLVLLTFPTNAPPKSYHHHLNSVVSLSNPKKPSMYRQNNTSTPISYYKDNFQNNNSSMTTARTSCNGSLVDTRESAEIPKNHVGVLSKRRRKKGQGYARRFFSLDFATCTLSYYYNRNSSALRGAIPLSLAAVTADRRKKEISIDAGAEIWHLKTDDGKDFEQWTKALQRASKIALGKDLASANFQKSSYQSELKQVSSFPKQEEEQVWEHIEALVSRIVGTRDAVERLFKKTAPSEIRANEATARGASTFKNSMSGEETDYFNHAIVPEKKTFWKRKCSSNSSSQVAGRPHLGKSTSSMVSAISIGANSSSVSPAENGLKDLSNQDINMHEHCSALLCDLNAVLSDFSELIARSKRCKTISKAPGGNCSDSNSTFSNTEFFDAESGHLDCSQAYGFNSASEDDLQTSDQDGAEDELISEASSLSSPSYDESPPHLNAVDTIFPSRSKNLDPLPIKLFIPRRELIPPVTVMPPSLIGFLRKNVGKDLSTISMPISANEPTSLLQRIAEQFEYAQLLDKAVSQTNPDHRLCYVSAFAISNFSINRCKERALRKPFNPMLGETFELLRTEHEVPSGFRFLAEKVSHRPVRIACQADSVYWSINQTAAPTNKFWGKSAEIITEGRVRLALHLSDGRDELYSWSVASCFLRNVVLGEKYIEPVGTTTVVNESTGANAFIEFKHKGMFGGRSEDVEVKINGSDGKSTGISLIGTWTNSLRIVGPGKSSDSEIWHVGELVEGATKRYGLTKFAASLNEITKIEKGKIPITDCRLRSDQRAVENGSLDEAEKIKETLEENQRIRRKEMEENGGQWKPRWFIPVDGGEEGEEIWKLKMGKEGYWEERSQGTWTGVSNVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4B6</accession>
    <name>A0A0B1P4B6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002829">
        <property type="protein sequence ID" value="KHJ31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4B6"/>
    <dbReference type="HOGENOM" id="CLU_2575627_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="81" mass="9118" checksum="91BC5DFD491A4BE7" modified="2015-03-04" version="1">MLKPQALSSNTTMSWKTSSVLEIWESKGASKFLEKVRCQIDAEKPAEGFSISALISFYRDSYGGWIRQPVCTLPIFLAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E1</accession>
    <name>A0A0B1P4E1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g3082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4E1"/>
    <dbReference type="HOGENOM" id="CLU_068908_0_0_1"/>
    <dbReference type="OMA" id="QAKDWAY"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="33220" checksum="FE581B5DA3B547FF" modified="2015-03-04" version="1">MAHLSPATIFSPSVAKKQIAEAKEWNIIDNWLLTKFNGKTPPDFERNSDTLKVLLALATFNENADEENCIINKIEINALEQLQSSTAKDPDIDLLTSLETKLTRDGKTCLEALSNLSVTLNRPFPKIDLLGQNLIDLQIKSDLLDQMSDRIGTLETNLNTELGYIDTLIGDLQSQVYQPSPGLAKQITQNQRKIKEISLKLPELRDRVASLSSASEGSTVTLQDVKLEEKSFNDLSKIVQELELEVKSYHGLPPDVRQARTELENLRAELYESISMRDRMFENLVESTNFTNKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4G8</accession>
    <name>A0A0B1P4G8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001344">
        <property type="protein sequence ID" value="KHJ33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4G8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4G8"/>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="OMA" id="NHVDAGG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059350" description="alpha,alpha-trehalase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112639" checksum="D11D96F915143BDB" modified="2015-03-04" version="1">MGLIFLLALFLKLVKSNDEFSYFSSPFVSWNQDEWTLSCSRYNPGAFQDWIPVANGYVGAAMAAIGPLFGEGTYQTNHTKQKSLNTWPLYNPKITFATVSGFLDVQENATGYNFPELSRDGWDSFISGIPHPTSIILSFFGHELNDSVSITEISNFMSSINMRDGVNKWQFTWTPTVNSDKISFDIIYKVISHRVIPNLWAVEAQVTASDDINGTVTDLLDGRSSLRSYLNVKGMDKSEDNNFHTIYSSVHPDGLENVTAWLVSGADFSNKYTDLNSRRLAAHGLLHLETERVDSTIGQTFDVYLKKNEPAVFHKFVTIASTDKFPQPERTARQVLKSAIRSSFSKILRDHVTAWRELLSAEKVDDFRDPVTGNLPEDQGEEYLKYLQISTVANPYYLLSNLRPDDQSNLNDDSVSVCGLTSDCYGGQNFWDAPTWMAPGISVTFPNYAEQINNLYKKQFPQALENAKAYGYPKGSALYPWTSGRYGNCTATGPCVDYEYHKNLDIALSLCQLKKITGNSTQFWEGPKSAAKIVDSIATSMSHLLSYNHTTKSFWIYNMTDPDEYSNHVNNGAFTLAATAKVLSLANSLRAERSLPISKYWEFQTENIKLPISESNITLEYERMNNSVVVKQADVILIRYINYDTNYPVSRQVLDLNYYALKQFPNGPAMTYSIFASLANKYIGQGSSSFTYTLKAILPYLRAPWFQMSEQSDDNLSINGRVHPPAFPFLTGHGGVNQIVPFGFLGLNLDNSILTIDPSLPPQIPYLRTRKMHFNGATFFVAMNNSHSTFTRIPTLISSGVKDGYGNGTMPFCVGHSRDCLKIYQIGINESITFPNRVDWKITSYFNNIIQNQPAWSENKYMSGEFPLAAVDGSTATFWQPQKDNTAFLYINTKVITPTSIKKFIFYWGSRHPKAVAVYASNMTDWRDQEGYVMIGQDKLIRPSNPYSAELEKESRVVPVSGNETTILPRQPVWTGKFLRIEITGCSAEDGKGATVGEFSVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P4</accession>
    <name>A0A0B1P4P4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002698">
        <property type="protein sequence ID" value="KHJ31649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P4"/>
    <dbReference type="HOGENOM" id="CLU_001331_0_0_1"/>
    <dbReference type="OMA" id="SQWTWDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="685"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="954"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="881"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1192" mass="136138" checksum="C8894678CC9ABD62" modified="2015-03-04" version="1">MSEVGATDRSRLLRSKKAELSGIVKSRKRKLREFFAVCDNGSPIPQLDISNPDTPPINSAEAHFLDVTDILQDRLFDESNLPTRRQIRLETSEHNSCIEELSLGNLKLNHTSRRVDKPQCDDVILKKSPVSTFGPRDNVNTCTSLLKNKAWDYKIERLPLQGHNSKSLCEILPKDQKDASKVTGYGTYATNFIVPSKKGKSDVEILVDNRTGITSTSTQDFIKASTSDVQLPKYPQSQPTYLSKLHNDETNSLNSILPQKTLYKQNEPTHVHEERTNQILSSRSTSQDRCKEKDKASSQNLDKFSSEISITHEESTDSSSKLKDRPDESNIYSQSDDKTKLLSQTAPHKEVLQLNVHDKTNPASVNVFSKFSEKELDDHLEIQKSKENKEKARSISEKGENSANNSKLKSTANLGSHVLNIAMRAKKKKNQRYHSAQKEGQLHSESYEETGIVNAEDLHWSSKRNDIPMTSSPILSENNQMLKGSLKSAIDSKLHLVIPTVPSKSLITYPSSERRNTRIGSGVLERKNVSEIFGDAIITSGSNSKSSSKSDLDAVKVPHLGSQVINSQRPATRVRILTQKQKEKEHCKLPNMIFSNKQINVNPKYLYETSVQSESLKEDYFLPLFLANASTGKGCLPALENLLTTAHKTITTSNAYVPIYENQTAKILKRIYNLQSSHKWSLRQPKRSIEPTRSRTHRDILIHEAFWMRTDFKEEYKWKKIISANMANACAEWVSSSKEKRKALQVNIAPLDNSPTLKETLTVRDFNIKSPTISGVSVSREAKICHDDSEQPQHSLLETVAPTDIFGLQNNDVVFSMGRSYVVDKLLSELPMYGRPLQVLNSEERVSGFDPDHYWRRPALPLSKYVEGKIRLKLNSPPRKKSRFEYEEEEDESQYKSSEKRTKKTPLPPESTEIALFDPKNRHILERIRNVNCFRPPSEFQMPLQSFFECRTASQWTWDEDKELKVLVRDYTYNWSLISSILTSKSKSDLATGAERRTPWECFERWIELEGLPGDMQKTYYFRLYTSRIENANKNIMASQSTQSINGQMQQSRKKSTTSVRVERRRNQKHLILIDTMRKLAKKRETIIQKQQHAANMAAMRKSQEVPHKTNKNLSATTPQDFSRLRHEHDFRKERIVQGQSRQEIQRRSVLTQRTSGLNNQHQSNILNAIRPFPSGISLCPNSSNARSHFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4S4</accession>
    <name>A0A0B1P4S4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hsc70 cochaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4S4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4S4"/>
    <dbReference type="HOGENOM" id="CLU_044224_1_1_1"/>
    <dbReference type="OMA" id="DMARNMM"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000005">
        <property type="entry name" value="Hsc70 cochaperone (SGT), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="37831" checksum="1B21CE6C02BAA4BD" modified="2015-03-04" version="1">MATIKQRLALSVIDFLNTSLSDGTLKGDDRDSVEIAINCISDIYNVDPAQEKVEGQRSLLEIYSQCDDIKTSLPQDSKVVADTSSSISSNNTSTGTKIEVSDEQKKQAEDYKSQGNASMAKKNYTTAIELYTKALEIIPKNPIFLSNRAAAYSASKDYKSACVDAETAVEIDPSYTKAWSRLGLARFALGDYKGSMEAYEKGIKYEGNGGSDAMKKGFETASKRVADQESIESRNKDQSSSDYDAPGAASGGMPDLSALAGMFGGGGAGGAGGGFDLNAVMNSPMFAKMSKNLMSNPGLLSNLMNNPRVAEMLGQHGDNREDRGGASMPDLSSLMKDPNIAELASKFLGGAGRGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U3</accession>
    <name>A0A0B1P4U3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002167">
        <property type="protein sequence ID" value="KHJ32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4U3"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="104" mass="11642" checksum="BB70484854D027AB" modified="2015-03-04" version="1">MHTEDLCMASTKCKNCGGPYRLDSYKCLARPTRAGKPTKEQLKIFRQAGDREYHAIVRAKIAEERAATIESYMDILINSLSENIATENSQASSVESSTEDARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Z9</accession>
    <name>A0A0B1P4Z9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g5106</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="JNVN01002621">
        <property type="protein sequence ID" value="KHJ31739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Z9"/>
    <dbReference type="SMR" id="A0A0B1P4Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Z9"/>
    <dbReference type="HOGENOM" id="CLU_006732_0_0_1"/>
    <dbReference type="OMA" id="SVFIGAW"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="20">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ31739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="871" mass="95110" checksum="03D0C858D2058ACA" modified="2015-03-04" version="1">METTLPIPLLPSVDLANPPSKSDTQLTSQQLSYLGCAYFYVTDSNIQEFFLYLEKNNVQPYVDVRSISSLPDVIDILNAGAIKIFVTLSQRKALEIDPNRLILIQTDYEPLPTEVKTNGILLDIQDDISNLDSYLLKLTEQKKQTIYLKATESCPKSYITLAQQYHSIPIISTSNLSVELDSQDKVSVPNYLASVWNSDREDKLMTTIVADVRGYTLGLVYSNCSSLRESLRTGTSVYLSRKRGLWYKGATSGDTQDLVRIYLDCDMDCLKFVVHQNGAGFCHLPQSTCFGNFHGLAKLEMTLISRKESAPPASYTARLFSDEKLLHAKIMEEAEELCDAKTKDHIAFEAADLIYFSLTKAIGCGVTLADIERNLDAKSLKTRRRPGNAKAKWAEKVGITNSQSIKTENPTAPEKLDNCPNSHNLVGQKIAMKRLDTSTLSPEAIKAAIKRPSQISTAKVTDIVIPIIKSVQEEGDNALLRYTHKFEKATSLTSPIIKAPFHSSLMNLPVETIKAIDISFNNIEKFHKAQKDDGPLRVETMPGVICSRFCRPIERVGLYVPGGTAVLPSTALMLGVPAMVAGCKKIIIATPPRADGSVSPEIVYIAHKIGAESIVLAGGAQAIAALAYGTNSVCKVDKILGPGNQFVTAAKMYVSNDTNAGVSIDMPAGPSELLIIADKTANPSFVASDLLSQAEHGVDSQVILIAVDLSEDGLKAIEDEVHRQAIALPRVDIIRKSIEHSLTLIVKDIEEAMALSNEYAPEHLILQIDDAENSVSKVINAGSIFIGGWTPESVGDYSAGVNHSLPTYGYAKQYSGVNLNSFTKHITSSHLSAEGLQNLGPTVMQLSKVEELEGHQRAVDIRLNYLKLNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P510</accession>
    <name>A0A0B1P510_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002091">
        <property type="protein sequence ID" value="KHJ32425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P510"/>
    <dbReference type="STRING" id="52586.A0A0B1P510"/>
    <dbReference type="HOGENOM" id="CLU_737676_0_0_1"/>
    <dbReference type="OMA" id="THGKWAD"/>
    <dbReference type="OrthoDB" id="5104731at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="37277" checksum="4ED01FB4BCD64A9F" modified="2015-03-04" version="1">MNLETYQRAALRRHLGFDSPSRDLVTQEASARYPSIKSSVSFIVERSPYSARPAKCSLPSCEQVFVSGRYRVAVTPAMRKDAVQNSDLYHVSCFERIADLSESAFLERIEPFTRLTNSNKPQEEYICAGAVERLVNEWKTRRLRWNTVMKSSFEDEKNFDNGDDMYDENNGDSEDEDVDEEIYSRTTIQKNQITERLVDDLMHNAGSSRFKPYGLVPGMQRHQYFLFLNSLAPWESDGPGDTQEWNLFDTFLGQEEPDRSRIQPSVNLSAVIEKWEKWVELVLTPDTSLTHEQLKEKGSIGEKGCRAIRRLAVIPIQQIPWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P519</accession>
    <name>A0A0B1P519_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001486">
        <property type="protein sequence ID" value="KHJ33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P519"/>
    <dbReference type="STRING" id="52586.A0A0B1P519"/>
    <dbReference type="HOGENOM" id="CLU_082824_0_0_1"/>
    <dbReference type="OMA" id="AFMPRLE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="28413" checksum="748449F93352D939" modified="2015-03-04" version="1">MKRILRPSLFPRVCWRSFTTENRARVSNSVSLTNSSPLELDVGEIRGAKFKVEPLRRSGEDVNTLRARLLYQSRKRGTLESDLLLSTFAEAHLRDMTELQLAQYDLFLDENDWDIYYWATQDPSFEPQTIAVDANIKQKDSDTFRESKHGISNRIENSQLEKTFESQLESEKRRNAKPRSGEWAQTVGTFKPEYRPVPMRWKNSEILAMLRRHVVSRSAGGISDTDGKNCSGGGGMAFMPPVFQTNCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P528</accession>
    <name>A0A0B1P528_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001480">
        <property type="protein sequence ID" value="KHJ33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P528"/>
    <dbReference type="STRING" id="52586.A0A0B1P528"/>
    <dbReference type="HOGENOM" id="CLU_010671_2_1_1"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="762" mass="85386" checksum="F999ADC833A079C2" modified="2015-03-04" version="1">MNYSFQHPSININNNVISSSLSDEDYFIDSASSAIQEYTESGDIQPLPLSYTQASNPEVDASNTGMMIEEYTGHQIQRDTFNENGNGYRIDQIHNFDDLQELREQEVSTPVDSHNDYQSERGNDTTFFQHSQMIDHYVVTPHLPILPEQRPLVNVLHQSSDSIENVRLNGPTQLGIHHDNQSINSPTSLTRITSNPITSIISSSSTRLNSLSSYISGNVSIPTAQTSSITQNSISNHNLDAPTSSNGTLPANNHTDIGNQDIEFKFDIYNFLHQMRRQSLSTSTNYSSNIPCPSYVGIEALRAFTPKPIQRSDLYGENCDFQGINWREIGVSRSKVKKYRSKHYFQKFGVQKPVYPYPIGESFANNENFFRFRRMDFGHKVQLLHPQLRNLISSPTRDHVFYVGRSKIHHYTPHNAEKTVTASVTLDLTNPMMPSPFSTTPGIHITTIAVGLNLLVAGGFYGEYGLVNLNADKGTDHTQGLITREPGGITNHIQIYSTRSKSSPVVAFASNNSCLRLLDAHNNKLISEQAFEFAINCSSISADKRLRVMVGDTQQILICNAESGEILKTLDGHNTFGNACDWADDGWTVATSGQDQKIKIWDARKWSTVQGICLPVAVIPTQMAGVSKLKFSPIGSGKRILVAAEQVDYLNIIDAERFAIRQSISLFGDITGFDFCNDGQDLYVANSDNTRGGIIEFERSDLASYGRYELDSTIHFKNNISRHQESYDWKSEDETLRDPKAWRTPETLERRCVSLGEEMGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P578</accession>
    <name>A0A0B1P578_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf455 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001429">
        <property type="protein sequence ID" value="KHJ33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P578"/>
    <dbReference type="STRING" id="52586.A0A0B1P578"/>
    <dbReference type="HOGENOM" id="CLU_050402_0_0_1"/>
    <dbReference type="OMA" id="YDDAMYK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="341" mass="38784" checksum="A9DA6FFA7194BE91" modified="2015-03-04" version="1">MQGFNMGRYVPPDQEGIKTGNQLHGKHALGARARKISQGILTVRFEMPYSIWCTTCPKPTIIGQGVRFNAEKKKEGYYYSSPIYSFRMKHAACGGWIEIRTDPKNTAYVVTEGARKRDCGEDKEECHIKLLTEKERDTLRKNAFAALEHNVNEKQICAQAKKRLEELHDLSEKQWDDPYEKNKRLRNTFREGRKQRERESKINSSLQEKMSFGYDLLPEDSNDVKRAGLVEFGVVDIDLAIKKATSKPLFSIFDSSLVPMSNPPILRRKNKAEEASLRKTAAIVAEIHNNTRAAIDPFLPGNRSSNFASSKLLTGVKRKQPIVDKGNEMKSSRVLVDYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P589</accession>
    <name>A0A0B1P589_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative beta-glucan boisynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001206">
        <property type="protein sequence ID" value="KHJ33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P589"/>
    <dbReference type="STRING" id="52586.A0A0B1P589"/>
    <dbReference type="HOGENOM" id="CLU_063732_0_0_1"/>
    <dbReference type="OMA" id="PEAFAIN"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061878" evidence="2">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="3">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="27822" checksum="E0205E5BFD48BFCA" modified="2015-03-04" version="1">MFYIYTLHALIVLLTIRLVHAYPQITSPAAGASIGGGTTFTVTWAESGDSPMITDLNSYELFLYTGSNTNPQQLYSIAKGDYTADYSLSVTIPVTIGGPTVNAYFLGLVSTAIKGGTITSFSDRFTLTGMKGTFPIAVKAALKQDSSISGPLAIVKVAAVMDPENPVEGFWDIPYNLQSGLTKYAPMQPIPPTAITATNTKALWPTSSVEFAKTLMPIPSQITTFTQSQTFSVLSHANTAAPASQPTNDMQKFLNRWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F3</accession>
    <name>A0A0B1P5F3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002513">
        <property type="protein sequence ID" value="KHJ31879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5F3"/>
    <dbReference type="HOGENOM" id="CLU_076142_0_1_1"/>
    <dbReference type="OMA" id="CDMLDRV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="23117" checksum="E58AF3D7AE77919D" modified="2015-03-04" version="1">MSNPYEIDHNISSKEASRARTRRPSMSSFFSQLAQVESTTTFHNNLHALPTPVDMAAAERLLQDQLLHFLSMTSSTQQSDFLQSLIRSIDQDIDQPPTTTPGVSQNFLDQLERVSRSSLKKGEECKICGEEFLDDEYSLVVQLPCHPLHRFDLECVGPWLRLQGTCPLDRKNLEEDRTKRLNDLIRNCHEVEEEDFDDMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J5</accession>
    <name>A0A0B1P5J5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dna binding protein sart-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002466">
        <property type="protein sequence ID" value="KHJ31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5J5"/>
    <dbReference type="HOGENOM" id="CLU_009379_2_0_1"/>
    <dbReference type="OMA" id="KRRDYTG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="653" mass="74209" checksum="3EFA6CE491531F1B" modified="2015-03-04" version="1">MADSISIEQTNKIRVSLGMKPLPTPNKSSPIFKKSSSAQPDEGSTLESRQAEGYANFRKLQEEEAAKKKRIAKLEAIKKARDAAQRFSKLEGKGLADDDNDDMDVKTWLMKQKRRQKEIEKVRKKEKELAEAEVGIEYTANDLAGIQVGHELEAFKEGEEQILTLKDSTIDENEEEGDELENLELRAAEKLNETLELKKKKPVYNPMDMDDSKNHSILAQYDEDNEKKNSKFTINEHGNVLENSAKDDSTSKKQIFSLDIIQDELESDYLPATIAKVKKPKKKKAKSIRQKMVDEDDIIPPPLKESISVIGGEGDNEKKPILKKRTYNDISLVDDDDLQRSLAAQRANVLKKRQKLRPEALVQKIREEALTPLGDNDTSEDKNALVIDETSEFVANIQKPSGPNRKKRSVSRQIETATQASDDIDRDGDVKMKQERPDSENEDVKPEHISQEKLLNSQITENGLDPEATLDRGLGSTLKLLKERGILKPENSEDLNAIYRQKQLFLAEKQRREAEAELKARAQRERDRSNGRLDRMSAREKEEYARSQNALRDQIESRQLAEHFNKEYKPNVELKYIDEFGRSMNKKEAFKHLSHQFHGKGSGKQKTEKVLKKIEDEKRRLAQSSLDGSQIGGMSGATAQQRKKQGQAGVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P2</accession>
    <name>A0A0B1P5P2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative c2h2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001915">
        <property type="protein sequence ID" value="KHJ32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5P2"/>
    <dbReference type="HOGENOM" id="CLU_036929_0_0_1"/>
    <dbReference type="OMA" id="MQMAHET"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="33655" checksum="1C289BFC736B50CC" modified="2015-03-04" version="1">MSLSYEAPRTFSDYPQSAMMHDSNDESNIHSHNHRYPSPPPPINNNQFHNSGIDHNQTLGHGTSLDPTSALIDGIAELQPKEEFDSTSPSRSKPIPKPDREVTKREDGKFVCRWPGCTEDVRVFNRKCEWSKHMDKHDRPYKCPAEGCEKLPGFTYSGGLLRHQREVHNLHGGPRKQLNCPHPNCKRFSGKGFSRQENLNEHLRRVHTDTNNELHHGEETEDDGAERAGTKRKRTTQASTIDTGEDIRQELERLRQENEELRRTSSNMMRQMELLQNIVTGHHLTRVRNDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5U1</accession>
    <name>A0A0B1P5U1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5U1"/>
    <dbReference type="HOGENOM" id="CLU_038592_0_0_1"/>
    <dbReference type="OMA" id="QSVPDWF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="489" mass="55892" checksum="41D398524043E131" modified="2015-03-04" version="1">MISHFSLDQIALALTVQKSKPKGLSTAEYCDQLRKHIKVGKPATTSKLRYVDTVEFWKDQYTRIHKQKEELEENINCVEYLKLLLRNEHQLDDNTLTTFEPYAHRLLSSALSRDNSSIWSLKQISTNSREQIPREYREEMVLGEVNLINFCSKALRIRRQRTLLEATLTNTGTISQIENIAKQTCRVLEVIEITMCESCKPFQLLKTSTSIVIQIFQNMMDQIAIAFLVCFDALSELCKNIPGRGYKYEITYRMVTFFQKSLELIHSNSSLQANHENSHNQEIYSKDSSTLEEDYIVNNSVTRCLTSILQNLNWEVKNPSHSDFCEGILFSILDFTGRLISEAVFSEHVAGSDNPGNITNNTTSVNQLAIKLESKYIIQILQAALDNENKKQIIAHVLSNNNKRFDQCTLVEPSISSKDLLSRATYLLQSTLVKSAVGGDDMESLKSPIPPTERINFNSVDQEEEKFGPEWLLEKVWAIIGWDLITQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Z1</accession>
    <name>A0A0B1P5Z1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002180">
        <property type="protein sequence ID" value="KHJ32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Z1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Z1"/>
    <dbReference type="HOGENOM" id="CLU_035244_1_0_1"/>
    <dbReference type="OMA" id="WLENPMA"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="40233" checksum="3E6CC71F579EBC10" modified="2015-03-04" version="1">MSFKTIRRSSSTVPLWYQTTQKKYNVQVHETVVRPPRSFIQRFRKHFSLYWWIYLAVSCICLLNVTLTSIYLLVPSLAQRNVDESYLFCSDLKFEKPTARSISLTQNVLLYTKTHFRPVLKPFTASLHSMNNGIYSPVPMSTIQFPQTQALYPVTSISIEKMVLEFKSDAWLNEVSKFTSQILSQEFVTMAIVGNGKVHLGALPEMNVHYNQSISMRGLNGLRGLSVTNLQLNLNATVGEPNMSGQATIFNPSVLTTEMGNVTFSLSTALAGAVGNSTIVNLTLHPGYNRFLLTSMIDKYKIAQSMDMSSGMVVLVVKGSSVVYNGEHIPYYEKALSRHEIVLPLNVTEVLLNSRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P610</accession>
    <name>A0A0B1P610_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">EV44_g5153</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01001836">
        <property type="protein sequence ID" value="KHJ32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P610"/>
    <dbReference type="SMR" id="A0A0B1P610"/>
    <dbReference type="STRING" id="52586.A0A0B1P610"/>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="367"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="472" mass="52329" checksum="A967E8F9FA2D816E" modified="2015-03-04" version="1">MDIANISADELKRVITATERKLQRLKVQLANVEAQNDHNNELEQQLEVAESRWRLLPEEYQRYGRQMVVPKIGIQGQLHLRSASVLIVGVGGLGCPAAAYLAGAGIGKIGLVDGDIVELSNLHRQIIHNNSTIGMFKVDSAYRYLKQLNPLCQYITYATPLTPQNAENIVSAYDLILDCTDHPISRYLISDIGLLLQKPVISASALRSEGQLLLLNWPPLSVGNEAGGPCYRCIFPKSPPAESVVSCGDGGIIGPVVGLMGVLQAVEALKLLVGGNLVNSISNKKAETKSTMFMFSANSEPQFRTVKLKGRRKECRTCSNQNVITLEKLRNGNIDYEHFCGILPSLTVMLDDKDRLQPNQFARQLDEGVEHLLVDVREKIHFDICSLPGSINVPISKLQSLCAQRVRDCKKLEWLPEPLSPQVPIYIICRSGNDSQIATKLLKEMGLQQIVKNIDGGFKAWRKQVDPTWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P621</accession>
    <name>A0A0B1P621_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002137">
        <property type="protein sequence ID" value="KHJ32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P621"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="308" mass="34299" checksum="579D6BB36FC27561" modified="2015-03-04" version="1">MWTTITQKGHQKSPSIAGLSQNVPTQRSSKNLPNYAAPSKPDERLFLRIDKDHEWRLAPSGVREILCEHLICIPSDVTHVTRTPTGFALTIKEEEIRQKLLNDSDRISSQGAKLEPASDLITYRIATVPVALRTSSGSVTVDDTNLVAEIIRVTNVAPNMARIHSKTRSGAPHRSWLAHFSREQAPRPGFRLFDESGVAILYKPCQPIPQCKRCHGFHATLGCSRAPAYENCTSTMHSINEYLAPTKYRNCGGPHRSVSRNCLARSSRSGPVSKDQLKTIRQMGQREYHAKIRAEAAAIRAEAAEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P675</accession>
    <name>A0A0B1P675_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002263">
        <property type="protein sequence ID" value="KHJ32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P675"/>
    <dbReference type="HOGENOM" id="CLU_536593_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="59243" checksum="92BAA24BED876769" modified="2015-03-04" version="1">MSDSGKGKSSSGSGQPNIFSLNKKLNDSLADIDTKFENLTKTIELGHANTNGRTEKIEQWLTRTEKVNLNTERRMDRIEEANHDIRKILIQIQNSLSSLENQLNSQTPPNIKYSESQDIKQPPKAEESKKMKENRETPIPSSIPNDKHQLTDVEKFVKETWPEALLDRDMDHHSFTSAKNKVVLKPEWRLTRANTDVLDKLSEIQSALRTALVPYYLWPERLTYEMSDDFKGIRVWATECKQITWVDMLNAIFKNLEMHDCLHNPLTTFASMNPTNDSIESFARRLRDSFYRLPRNDRSSSTVQFMITDLCSRYLPRVWTIAEPVLFNLRNDQRIEKIVQIARRVSRWDDEYNKFQKNSVDPSLPLTLASSHTDPNLYPIHDNQLEQAYVSNNDVCYHCQRKGHWASKCPYKHQLDHQQSRTPYPDKAIKNPYFPKSNPQNSRILVPRHDKVKQYHQKRNNTRTYLIDSDDLYDTNDIKTSPICCLDPGQDDDNLDNIINDMEDCNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K2</accession>
    <name>A0A0B1P6K2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001970">
        <property type="protein sequence ID" value="KHJ32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K2"/>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="614" mass="67151" checksum="DB6B2F5EE54A56C4" modified="2015-03-04" version="1">MTTEVYDGAIGIDLGTTYSCVATYEGTNVEIIANEQGNYTTPSFISFTDKERLIGDAAKNQAAMNPRNTIFDIKRLIGRRFDDPTVKKDIESWPFKVIDRDGSPMVEVEYLKETKVFSPQEISSMVLAKMKEVAEVKLGKKVTKAVITVPAYFNDNQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLGAGKSSKERNVLIYDLGGGTFDVSLLNIQGGVFTVKATAGDTHLGGQDFDTNLLEHFRKEFLRKHKKDLSGDPRALRRLRTACERAKRTLSTGAQTNLEIDSLFDGIDFNTQITRARFEELNSKAFNGTLDPVAQVLKDANLDKTRVDEIVLVGGSTRIPRIQKLLSDFFDGKKLERSINPDEAVAYGAAVQAGILSGKATSADTADLLLLDVVPLSLGVAMEGNIFAPVVPRGQTVPTIKKRTFTTVADNQQTVQFPVFQGERVNCEDNTSLGEFTLAPIPPMKAGDAILEVVFEVDVNGILKVTATEKTSGRSANITISNSVGKLSSSEIESMVNDAEKFKNSDEAFSKKFEARQQLESYISRVEEILSDPTMSLKLKRGNKDRIESSLSDAMAQLEIEDSTSDDLKKKELALKRAVTKAMSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6X5</accession>
    <name>A0A0B1P6X5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001896">
        <property type="protein sequence ID" value="KHJ32676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6X5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6X5"/>
    <dbReference type="HOGENOM" id="CLU_000384_42_10_1"/>
    <dbReference type="OMA" id="IKEGHEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21290" checksum="01731AB83E4350CA" modified="2015-03-04" version="1">MGRAIDTKETLTELLDKNYIRASSSPAGAPVLFIRKPGGGLRFCVDYRALNAKSKADRYPLPLVKETLAKLSESKWLTKLDVGAAFHKLRIKQGDEWKTAFSTRLGLFEWLVMPFGLNGAPASFQRYINETLLEYLDDFCSAYVDDILIFTDGSLSEHENHVHLVLEKLQKAGLGLDIDKCGFYVRQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P706</accession>
    <name>A0A0B1P706_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sna41 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P706"/>
    <dbReference type="STRING" id="52586.A0A0B1P706"/>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="735"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="872" mass="97635" checksum="8BB68E175D7B4C4D" modified="2015-03-04" version="1">MYLPRSLISSLYLNLQRTHHPLSPPVIILVALEPDALCGCRILTQLLRRDYIPHKIKPIAGYGDLQKAGHDVIRPMMKSCGGNGGVVICLGTGGLVDLGTLLGLESEEEEVTYCGVEVWVLDARRPWHLANVFGGVPYLPQQNSDGQMASAKTPGVERGKIQRGYKPTNGGIIVFDDGDIEDDLTSERDSFFAIMDMPEIGDSMDERDTHETDSDESSESDGDFETLIEHRTSKKRKPIYYSDEEGQSESGRPHQRRRRSNSSSPKHKSLNHRPQIDLVSMKEHSVDQSCSRSISPPSAQPPAQPSARKLRRRLLKLRRKHESILQRYYKLGASYSEPISSMMYSLASELGREDNDLLWMAIVGVESMELYGRSSMGISIRTENLSSQKGWLGIRGFQIRQLIRDEVRRLNPPDLSDSSIGVNRYSSPEKINVIPIAARKPTDTSIQLSPEPRFLLIRHWSLYDSMLHSPYLSAKLHIWSENGRKRLHKLLAKMGVSLVQCKQNYTYMDMELKRGLRSKLLKYSEMYGLDGLVPAIDTGGKGINSTMEGWSFVRSWGWRGTFSAQDVGVIVGAILEVGKKPFTKIFEGSADKGDDLANIPDEDGTLESEEWVGRFWDAYDALEKIEELKAALPTAQHLHRAILRTGIALLEKHQVCHLRAFRMCVVKDGPDVNLFTHPSALTKLALWIGEAIAQQEKESKGKLGNSGRGTPLVVASLNETRGIYVIVGTGGGGGEDSVGFGDRQATKDKRKRHETMAKRKELKQKNKEFLRKKKEEARRLAMDNELDQEDESDTDTSDSSSSDDSDNGDNEGDQKNYHKGFGRNKFGNAFQEVVEETSARVRIDSFEHCVVEVKKEDLATFLENLSMKAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P742</accession>
    <name>A0A0B1P742_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P742"/>
    <dbReference type="STRING" id="52586.A0A0B1P742"/>
    <dbReference type="HOGENOM" id="CLU_016785_0_0_1"/>
    <dbReference type="OMA" id="VPDYCYI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000046">
        <property type="entry name" value="JmjC domain-containing protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF101">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="346"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="497" mass="57787" checksum="4C711F60BD66E0DC" modified="2015-03-04" version="1">MNQEICILHQKLANICLSKFCCVEYVTEVLWDESNFSDLKLCGRPILQLLLHLIKSICNLREDYEEWQHHRREENKFSLIIKRLDDLITLATEKFYAFPYKDVPKCWRQLFWEASLLKFSALVVKRNNENSKSLLESSYMDEIVKTIDMAHIMAGPVTSDCIMGSITMIFEILQEISHSLLPRATNIGLKQGKYDCQESLIDKFQEVVNFKPQVTKPVPREKMMPFCSFERYLQYPSNFQLGPEPLIITEAVNHWPAFCHHPWNCPSYLLSRTIGGRRLVPIEIGRSYIDEGWSQKIITFKQFVETYITLDNTSGSYEKGYLAQYDLFSQIPLLRYDIAIPDYCFVSVPTLQSTSILAERYSQVPRLEEPLINAWLGPPSTITPLHTDPYHNILVQVVGKKYVRLYSPKESKNLYPLGIDKNGIDMGNTSDVDVGTFAGWDKTKEEQEETRRKFPLFEEAEFFDCILEAGECLFIPIGWWHYVRSLSVSFSVSFWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P770</accession>
    <name>A0A0B1P770_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001051">
        <property type="protein sequence ID" value="KHJ34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P770"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OMA" id="PTWIGVC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="101"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="61796" checksum="7F0CE9A948FD25B1" modified="2015-03-04" version="1">MMTEIFRNSAENFYCNSIKYISDLRPSLSTSVLAFYRDSEPEKTDARGQSLHHLKNSKEFPKDELILEIGISTLYKPYDKKCIIINRAIEDVGMGRYNWSLFVLCGFGWFTDLLWIQQVALTLPSLSTEFGVSENRVRYTTCYMFVGLCFGSIFWGVGSDIVGRKIAFNLTLLIAGIFGIAVGAAPTWTTVCVIYFGIAFGVGGNLPVDGALFLEFLPNASGRLLTLLSIWWPMGQLVSSVSSWGFIGGNFTSDKGWRYSCYLMGSVTLIMFLAQFFLFHLLESPKLLLARGRQAEAVAVVHGMAHKNRTTTWLTEEILNELGGYPEPNQPQLLTRKEMIRSKLSAFSFKRIRPLFATKGMARNTTMLWYCWLAIGMGYPLFNGFLPQYLSKGQKATGEVVSEYTTYRNYVIISIMGIPGSILAYYTVDLPYIGRRGTMIVSTFICGIMLFLFTISFQASFQLGISAVESLFQNVMYAVLYSYTPEVFPTSIRGTGTGIASLLNRVGGLCAPIIAANVPLENPNIPIFVSGSLILSAFVAMLFLTIETRGRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P789</accession>
    <name>A0A0B1P789_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000817">
        <property type="protein sequence ID" value="KHJ34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P789"/>
    <dbReference type="STRING" id="52586.A0A0B1P789"/>
    <dbReference type="HOGENOM" id="CLU_726026_0_0_1"/>
    <dbReference type="OMA" id="CEWAENI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="45"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="43216" checksum="357E4741D8BA3442" modified="2015-03-04" version="1">MKSESHTQGFSEINQPKDTFSAACIDLHSDEESEKDQWEYEYSNTETETYYLTLDLSTPEVPPTHPPFDDTIRKKTRWLNPSIGRHRRQTPLPPANRTAKIYTLDGRISPDENEILDKASEDEVEKTTHTVSEENDQIPKSVQILDLETHLPIVAFDGHVYACSWAENIGTELIFTPTDVDNSNPLPKLRTLRGNVDLLASSTARLVARSLKLTPLEKNRNQVVKPRAKNKVLIPVGHAASQQRKNQALFLEKLSLAKEKRGEFDSVTINAKPRLPPRKLRTLFEEKRAQQRAELQNEFRRKNASAEEKEIAKMKLEHMDREEAEWEGRGESYTKAGRAGGRPKKVPMGIGDEKIIKSTLWSQRNVKGKGKGTSSESIEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7K3</accession>
    <name>A0A0B1P7K3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutaminase a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001726">
        <property type="protein sequence ID" value="KHJ32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7K3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7K3"/>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="OMA" id="WTGYLVR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059398" evidence="1">
        <location>
            <begin position="19"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="357"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="528"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="678"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="812" mass="91722" checksum="563D99E3BAC9FB70" modified="2015-03-04" version="1">MVSLFIAALAAVIITIEASTLKPPVLPLIVRNPYLSAWLKNARGNPWENWPIFWTGQEIGLGILISVPNTKTVYPLLGRPQDSLPKFGESFTISYPKYLGSNFDASTTNLTYKIPSLKIGSEDTKVTLSFLSPITPTSTLRQSIPASYLSVYVTGSLNIDLYIDINGLWVSGSRDSEIVWDIVHQNHRESASPSLIRSWRVKRKVQQLLTEELDRSEWGTLYFSGPDEVKYEAGTSALLRQKFARTGTLDNLIDNRFRPIMNDEPVFAFAKSFKLNATENCPGFIDETITFSVAHIQDPIIKFASARGLTLMRPLWTNYYSTPEDLISFHYYDFKKASNLAGNYTRQLEKDALNSGSTDYKDILALSARQVMGACSFAGTPNDPMIFFKEISSDGNMNTVDVIYPASPFFLYTNPRWLAWLMEPLIEHMLSGQYPNDYSMHDLGSSFPNATGHPDGRDEFMPVEECGNMLILGLALINSLQYDTKPASIWSAVGETKYIESVNGKFSLHIDTAGMDDTFGGPLSAKGKKQAREWIGRSYPLWKQWAEYLVREALIPANQLSTDDFAGWLANQTNLALKGIIGIRAMADISKIVSKHEDANNFLQISQSFIHLWHKDFAISRDRSHAKLAYTWFGSWTTLYNLYADSLLCFHLPRHLRKKTSSREFQAILEAGEMKMSRTAFIHERIYKRQSDWYHSVRQRYGLPLDSRHLYAKSDWEFFAVAVSSRHVREEIVQSVALWVNETSTDLPLTDLYDTEGSGGYPGFLFKARPVVGGHFAFLALERACEGKAVHALKFLDDIKPEASQRDVKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X8</accession>
    <name>A0A0B1P7X8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001413">
        <property type="protein sequence ID" value="KHJ33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P7X8"/>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="OMA" id="AEPLSQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1507"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1863" mass="204918" checksum="DE7AF43C74CB41B8" modified="2015-03-04" version="1">MDQRINSTPVFDSERRTSSNATSRVTRAAARQAAGFLESANHFTGAPPVALPNRISETARKRKVPTLEPDRAPSPVPVAQEVTRTSISRRPKRQKVAAETNHTIPTPTLAVAASSRRKKGHNTVVMSNPGESAGPSTDHTMVSPGPKRKLTRSKKNNQDSSINTPSSSRRFKKTNTGIKEAEQLMTSNPIENSHPPEGDDGSVEEEDEEITRHYEGQDDDEDSFGSFGGPGGASHGLSSTLRALSTMMSGVSTRLRDILKNLRQKGEPSLQLIALQDLSEILLVSTEDNLSGHFSPDAFVKELVTLLQPSELDEENTEMMLLACRCIANLMEALPSSVANVVYGGAVPVLCQKLLEIHFIDLAEQALSTLEKISVEYPASIVREGGLTACLTYLDFFATSTQRTAVTTAANCCRNIPNDSFTVIRDVMPILLNVLGSNDQKVVEQGSLCVSRVVESFRYHPAKLEELVSTDLLKAILRLLLPGTTNLVGSNIPTQFLRVISITAKASPTLATELLKMNVVETIYQILTGVSPPGPSEDAASKLDSVIIMQALIHRSREQVIETLNVICELLPGTPRETDLFTESSNINSSLTPDEIPISCSRKHSSREKRLELLEGCKKEVKRFAVILFPILTDAFCSTVNLSVRQKVLSAQLKMLSNLDEEILIEALQSVPYASFLAAILSQKDHLSLTVYALRAAELLLRRLDQIYRYQFYREGVITEISKIANSKGDGHPITRPEIMYEAIDATVSNSSNTTAKISEKSEQLDEVGTEDNDSLDGDERGDNDNDELPDDTSPSPSSSHGSTMSLDGPSNRISDTLCLKNFIVQRAKAFLDAHENEKSSQDMKKKASKILNDLQTLALNIESHYLHRASGNGNGNGTELFSSLASYFDGDLLESVTSAELLNSEIVRVLLDVFNNKDERLSNDARSSFLEAFMGRSVARKFKPTNTESPATPFSVLIRKLQDLLSRSEHFEVVTVHQNSFDGNKSSAASMLAKQIRLKLVADENSEIPRPYRNIMVSIHAIATFKALDDYLRPRISVSERSRGSRARDGLSGALAALAAAGMPNPFAGAGHSRLTDHEPVTTNTTSPVTPSLQKTDSKTMHSISSASGRQALITKSQRSISRRPNRSFAQKELLGAPPDDDGLTPTLECADEKGLTTENDSNDSTALDTIVGNLDDEIGDGSNLDTAAVNLEIVASEKITARKEGGSRLATPPQAPNRGDSSIQPPTALATLIAQSTARPISYAAAIQATPQDWHIEFSLGDQVIPNETTIYRAVHSGAHAIEEHGTRSVWSSIHSIRFKRVSGPPPPEISSLSNTPETNLDRTVSGIPASLDKHQATSSILRLLNILHDLNSNIDDVLAENKDTLKLNVEPLSQFVNTKLTAKLNRQLEEPLIVASNCLPSWSEDLARCYPFLFPFETRHLFLQSTSFGYARSMTRWQNAQSADESRRDRHRDERTFLGRLQRQKVRISRSKILESAIKVMELYGASQSILEVEYFEEVGTGLGPTLEFYSTVSKEFSKKKLKLWRETDCNNTDEFAFGARGLFPAPMSEEQATTENGKRILHLFKMLGKFVARSMIDSRIIDVSFNPTFFRIGDASKAVSPSLGAVKTVDPQLAKSLKLIKKFVTGKKAIDENPNLTPAQKVREAEQLRVDGARIDDLGLDFTLPGYSSIELLSNGSQVSVSIDRVEEYLNKVIDMTLGSGVQRQINAFRTGFTQVFPYSALSAFTPDELVMLFGRVEEDWSLETLMDSIKADHGFNMDSKSIKNLLQTMSELDLTARREFLQFTTGSPKLPIGGFKSLTPMFTVVRKPSEPPYTSDDYLPSVMTCVNYLKLPDYTNLEVMRERMTTAIREGQGAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P802</accession>
    <name>A0A0B1P802_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000911">
        <property type="protein sequence ID" value="KHJ34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P802"/>
    <dbReference type="STRING" id="52586.A0A0B1P802"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_0_1"/>
    <dbReference type="OMA" id="HEKCESR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27148" checksum="EE0809D86F1743DF" modified="2015-03-04" version="1">MSTLTALELLTEHIHTIWGNDNKKKVASILSLNISGAFDNVSHQRLVHNLRGKGIPSWMTTFIESFLKERSTAIVLGSFKRDQIQTSTGIPQGSFLSPILFIFLASTILPTLQTATSSAVGFVDDTNILTWSDTTKENCQRLQQLHEKCESRARTHGIKFAPNKYQLMHFSRARNKHNMQAPIIIQSHLTNPQISLRILGTHLDPKLNWGAHIKNVQGKGRFTNASTEQTRTINMGSNFSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8M1</accession>
    <name>A0A0B1P8M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative alkaline ceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001289">
        <property type="protein sequence ID" value="KHJ33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8M1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8M1"/>
    <dbReference type="HOGENOM" id="CLU_063293_2_0_1"/>
    <dbReference type="OMA" id="IMFEPLR"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="326" mass="38176" checksum="505BF93E2E768631" modified="2015-03-04" version="1">MGFYLPAYDYPPSHSNDGYWAPVTSTLNWCEEDYYATLYSAEIVNTVTNLIFFILGIKGLRNCIKYNHDSAFKIAFLGYLFVGLGSFAFHSTLKYSMQLVDELSMIYTVCFMCYATFSLEKSKIFQKMLGFGLLFLSSSITLSYHYLKVPAFHQVAFGVLIVTVLFRSMYVMEFRIRKSLREKYALAFHKDSIDLVSSNYSREIKNDIDMLNKMWLMVGFGLLLFVGGFVIWNLDNRYCSTLRHWRHNIGLPWGILLEGHGWWHAMTGYATYIYLVWGIWLRYYLNNRQREFGLHWPSIYFSIPEVIPRSFMKPILCIKSESPKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8S1</accession>
    <name>A0A0B1P8S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001265">
        <property type="protein sequence ID" value="KHJ33730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8S1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8S1"/>
    <dbReference type="HOGENOM" id="CLU_556909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="490" mass="57373" checksum="D38CF50EF4F6C614" modified="2015-03-04" version="1">MEYIQSTTKFNNIFNKVPHELCLKIVDELYLEDLLRLRLVCQSWYQVFCSIDICVHAIKKYFSLPIDYYFQKSGHDYAELDDSKKKEEWLRKFIINRIRREHGIATRSFELDYNLWRGFFNFRYSNGRVVFQDEHGFTVEDLTTRQQFIFASPLHAVLLTNWQLSDRYLLVPFAIYSSGPISRELVAWDLASKRMHSIRIDEKVESLSAYQNQVGIVTVSSVDMTDSFESYVWQVGGALTRLQQIKHKRNSSEEKIVAIDIFFHIFEKDVIFLVYHSCMSSSFKTGKHGTRITVQCFEAGVHTQTQYETIYTSTKPEDHRSVTITNDNIICIEVWENPELGSNKDSYTHVTYDMGRRKFNRLEVHLHPISGRNLLEHKNLIWRDQIYNPFLEGIFGEMRELHVITLSKSLTDIWFGPSQSTCYTKLSFMKSSLLCSETRENCVSTKNLKIYDTPTGWSRRAWGDDSFLIANLGGSLRVWQFDNLGLEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8S5</accession>
    <name>A0A0B1P8S5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000761">
        <property type="protein sequence ID" value="KHJ34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8S5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8S5"/>
    <dbReference type="HOGENOM" id="CLU_1372190_0_0_1"/>
    <dbReference type="OMA" id="TSIRHET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="4">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="23923" checksum="40604979BF43A7EF" modified="2015-03-04" version="1">MLSRCRWFSKIELRWVPFLGWGIWAMGMPMVSRNWTKDKKELERVFAGITEGRWPTWLISFSEATRYTKEKAEESKLWCKTNNKPFPQHLLYPRVKGFVTTVQYLRKASHIKSVYDVTIAYSHNNKFQTAPSILDSLILDKISSRRGYRFHVDVQRFSIDELPEIDAELALWLENRWVEKGKFLQMKKDEWARDQRSIGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Z0</accession>
    <name>A0A0B1P8Z0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosomal protein s15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001454">
        <property type="protein sequence ID" value="KHJ33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Z0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Z0"/>
    <dbReference type="HOGENOM" id="CLU_078264_0_0_1"/>
    <dbReference type="OMA" id="HLQEHRN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="35079" checksum="E40F87EB738CEBC5" modified="2015-03-04" version="1">MRTQLLASTGFLFSNLPYRLGPKNLNLITAPKEFAHIGTLATSKKHHDPYKLAQIKLRRDANISRQKELQEERKLAMGDPVRGTTTPFVESFDNVASLVDTGAEAETVVKKKFLNFYVTNEELEDAMKNSHFLSSPIIPQNRLGVDPAVEKKKVELHESQHLNAVEAIKRIISLSNASSEEKTRVNISRCIEKFGRHNTDQFLDPRPPVNPLFLKGKKMPEKCPRAGPDTGSSEVQIAILTAKIRVLANNLELAGAKKDKINKRNLRLLVHRRQKLLKYLRRKERGGGRWKHLVNTLGLTEGTWKNEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D1</accession>
    <name>A0A0B1P9D1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000662">
        <property type="protein sequence ID" value="KHJ34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D1"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="131" mass="14345" checksum="B6D0E4327F328BC7" modified="2015-03-04" version="1">MICTTVLSNIHSTLANLVEDIEKEEADAIKAYLRLAISNFAAADSSPYPPRVRTHTRPNKGDGNEKGKEIDKNLSKKTAVATPRVILNRSPDRGLNVNTELPKIPKLSDNSWATLARKGQKKPRIDIGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N2</accession>
    <name>A0A0B1P9N2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001491">
        <property type="protein sequence ID" value="KHJ33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N2"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="35131" checksum="052CDD58F808B923" modified="2015-03-04" version="1">MSKFIPQELAEIFGIRQRREHAWHGRILICTSVISNIDSTLTNCKDEFSREEATAFQVYLRQVISKVAPHDSLPTPTPIPSKSFHKKQSEIPSPKLPNKPILVASSVMIPTSTAIHYPTHVTQPRENSTTQSSWATVTRNSQKKARVTKDNNTKPIQAKKANRVERLNEPRALSNSPRRQALEGKSTPPGNADKRIFLRLPQEHEWWNLSSSVIGEIVVKKLAISPVTIGRIKPVHTGFAPSLCSDDAREKILEAQKDLFISGVKLEPATNWVSGIVPTIPTYIRTLQEKIEVNKIMLADEIERVYSLRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAL5</accession>
    <name>A0A0B1PAL5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative c6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001283">
        <property type="protein sequence ID" value="KHJ33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAL5"/>
    <dbReference type="HOGENOM" id="CLU_011074_1_0_1"/>
    <dbReference type="OMA" id="SMENILH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="71130" checksum="33D8F654CFD82350" modified="2015-03-04" version="1">MMGAQVPEDYNSSQTELLQSGKITRNNGLPTSESQAPKSVAFELLFTQSSQHRARIPMRVQIFPHDTTESIVTTVKNFYGLYSSPICMTGVSFEDEDGNILIARYENFRNNMIVYVRIISEPIQSTEIMGASAFAPGATALQNPYFSDNIHTTLPMMPAQISNYDQARAGSRSTSKISQNHSVSPSHGLTNSIPPKKTRSRSGLKSRGAVTQGSTLPKAKNEQIGSTEISLDNIVEGGRRKRAKFESSELPLFAPTQMPAVISNSSASPARCVEHQRLTIYTHASAQGSYGNSQVLKSPHSLQNGFGKSLVYSTPGAEGRDTYGETSNRQSINSNTPSCNSSGVIPTPDPTVGSCVSEEDKDVALQLMRLGELSNISKNRTLTSTLDDTFSGKADTDISTGATSEYESNNEFDLPSNHKIKRDLSPALSCGVMDSVRPLSRDEIPSQDSTELSYDDCEYEDKCDSTFNSKPKKTILNNVQRKTTSAKSKIQSRTITSKPRNSSSGAKQKLGKSKIQRSSQSRGNKLKSDDIKPISPTSMPNSRKTSNASLLNSQPKIGEYEEDLSSKPRCQRCRKSKKGCDRQRPCQRCKDAGLTAEQCISEDEGNGRKGRYGRHMGVPVKKDASTLGNASRSPPITSVENNPTTNKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT3</accession>
    <name>A0A0B1PAT3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000431">
        <property type="protein sequence ID" value="KHJ35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAT3"/>
    <dbReference type="HOGENOM" id="CLU_000654_0_0_1"/>
    <dbReference type="OMA" id="KVERWIP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2700" mass="309180" checksum="FE79E0F39A00E3F9" modified="2015-03-04" version="1">MKKLTKRPQNFGVYLGRFENPPTIFETQILSRWNLLIIDPTAPGVFEAISSGIYAISPQILARLDLRLIENQSTLMQIVTLTEWMIKYMSVIDKAASLEVYLEVMDPEFLCETELVELQEVNGLIIRNGTILLNGEERNSFQMVQLRSTIKAFISQTCLRSFVVLLWETVNDRAQPSNAVIRRCYQWSRFYNVVPWIGTRSALNTAGLSYNQKEPLGAFDWLKKIQVMKIHKQWSSNQSIYRHCNDSKSAIIEQICAALLIPWDQMSCSVRIILKDEQSLASEPWIKCPKLCPKALNISTSHFDPELVSNYSSNSISSILFSETQLHDSLENQVLSISVSGIRFDYLGCFPLGISVTCKDFANVVQLQHRLRKMRLLDETKQQKLQEMGIKFQQFFEYLYYQGKQTDLKWPILVKTLGQQLSNLSDNHFSIQVFFGLNSGFSTEGDSHFWSVFEFDNERTLIIYLSADIHQDFEEVILHTYLSSQGCTRRECFQAELIFAEWTDSLIQPHYLPKRLIKDISLLTPSELLIFLQDLTLHSIKNTPNLVTLIIAYIKKLLLDYTDVLQLKKTDTIGYLSGKVSPEILINARIKWYQQNNCHYPDPKQALEMFLRTNISINKILRNRKLEELEKLTKSLLDLLNSGNIDVRTDLIYFSVFSAFKKLAFDETYLEVTDRNTLFNDQSDQAAAYAELFSTGARCEAYFDITPNELGKLLSDRYRKHHHQSNHEPPIWTDAESKIFSTYAAAKIDVRQGSKKKKISGTQRLTSLSVFVVPALVDTILLTTTGRGLYLSEFMTHTEQYTATLALMVSLLISGAVGTWVTCGGSYYLISMAFSAMNSFLVTRLIGGIAFTLITGLFGLIIFCLTQGLLAGIIFFLYLIALSSYLCLLVALANFQYPGSTFQSGRPMILILFPFLLASPIISSWIPEYDIYVYLSVLYSFLILLTLSIRYLGSLWSTWLFSIETIDDQGLKKWYINRYQSGSEKILSNISESALLKIARDTIIRDVKSAKKIFWKKINDPVIRALAKSYDASVFLLEWYSVYSETPLPIPFSSTWNIQMKVALKTLKQLQTGIKLHNAFIHWRQAGDEVGCNILYFIIALLDKWNAILAGGKQVLSLSATNQQFKVPSGFALAYYLIGAVFLEFNASKLHTMTTQGQNLLIGDISSLPEVLKCEVQARRLLYWTMLGRYCLFHVWSLAVSFGLIWIYQSTEDSTVIFLAYVGAYTGLLWYQYTKIFTGPRSLNPLIIAVILGILTGQLLRYSVPSFIYCDVIALTVATWTAAILSLWFAQIKSKRSDLRIYKVSGKNLVNAHNKNGSIYHAFTELEKDPLLSQDELHTIFQGMLRVRYNRINPQTCPGLQIRSILLDSLGIYHNPREELTKFALRAFPNAASLLKLAVIYLEQGDVVIDCVPIKIMTNYFIGLRAVSCFKDDKLRIVFGCDVENINEQISVITRFSQFAAETVLHAVAENYMNLSHDDSFLTESLLALRPLTYKSKRLFTPTWVSNYLRSPMYSSKKARIFAVYCERQTLKYLSLRFDPDIKWQSLPRKIRELIIKRCLGQEFTCDLSQDDLPPCCKIEIPIETYIARCDFGAYMAVSDQVFAAINGGKDTVKVNSYQYNFKQQESLSWINDSFKPTYICAVKCQFIKFYQSIGFFFKLLVISFVADPELQRELDYVLQNCNHIIRAISLFLSTSIWNYSKKLQNFLMPIFLLYRRKTIIKFWNQIGSTKVSLKHHKVLLENSKGYSSAFILPKSKDGTFQVFMYSGNLDHAPNDNTNLQRISTYSYKSMALLRLEEFCQASKINTYQYEYSLKPLRKRKISKIKNDRYPIRRICIAGRDKDEEINFNRQGLVESGSYRIYGNIIKFKCYYQKGRNYDGELLRADFILSHLKCSVSWSVPPKSHPERLENWIPHPQVIRATFIVDTDIYEAHWIYDHKFDPIICTTLNGQPIETPKMIKWDYLGVLKKPSNCSFHHDDLLINFKTLHTNFFMRLFGLNTHQDRISTSCARSRLWNAWKNIPEFDGVTARWLDEKLLRKEPILRNYWRLRDNGDLGGAEYFLNENADSVMAAVDLDNSISGWAPLAIKIADLYSFGQGGDANSRKRSKIFNFNGDKLQVLAIDSGTWPNEGGGVSACRRDMINNLHRVKCLKIIPLWGLDFLTPTHGLFEDRLNTEVEHIFCNSIKSDVKLNFVPVLKALVRGARTNIHTKNDILQATRALVNLNAYFSKGRHWSTVWTSKIVKEAWRNLWTCHDLANSTTSGNWFRTEIPTIEQLDISLELWFRYLFIFSIPLPEQIPAIFQASHHSVSASYGIICKIKRRCILQIWDHAISWREANLYLSSDLCSMAPFTRNALLSLMRLTSHLILHHADIIVPCADFFNPGWEIEIGTCQGSIENRNKFRRKINPVVNGITDMEKFTSIQRVIAEKPTVIMLSHIWYAKDIKTSILAADIIVNQWGFKDYRLEVYGAIDKSPSYSMDCFELIASKSLSKFVTLCGESDPVTVLKKTWVFMNSSISEGLPLALGEAALTGVPVVCTDVGASLRVLTDPDTGERYSAVVAPNDARSLARAQICILALLDEWAQYANDPNGFSVPSLSDNPTEADVEAITSRMYQKSEERKALGMKSRKIVQKSFGGSRYLREHEQMLWICKARHDTKKRVFTSTESVLNKLNVKPINRRRHIPIHPLLRENQNSGSIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAU0</accession>
    <name>A0A0B1PAU0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5215</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000429">
        <property type="protein sequence ID" value="KHJ35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAU0"/>
    <dbReference type="HOGENOM" id="CLU_000178_4_1_1"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000017">
        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1437"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="2121"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2429"/>
            <end position="2461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2461" mass="279999" checksum="6AD45AC4C2199026" modified="2015-03-04" version="1">MMAPRSTYVHKLKNTTAFTHATSDVPPSSTAIQLISKVTTANKSSSQAESNELQKLTTEVSDYENSSSKIDDPETQIRHIHKLTYVLSRAVLERLQKNDPYINFEELICQAGETLDLFCINFEAYPMVLLYQLTPGESFQSRGSEPLWAWLFPRVLGLLGPTRYETLTKKIRTLFLLSFQSTHRMPNLWDVGSTFFGYLKDCASTTLECIRKQKPHSFRIILPPKEVEYSFSQDSLDSGTGITDFRHTYIISGFYSCLRHVGYLLIMLTTFMEDSSQPLSPNLIFQDYFVWLLDSIFEAQDILQMLPTVTHSLDIDKNIDYLLLKSMQILLSNSQGIRFPIILRKGYSMLSLICAKILERRKEYSEEMQKNFSEAFHDLELFCRKNETVRRITATHLVPILNNSLTESVVSPELKISCSILCQTCAARKEFEIKTSGNTLNEHNIDEDNEHSRPGLQNMLEKSKMDFDASPPTKKRKVDERNLLLDELTSELYNILGASKVTNLNGLSGIVDQYFAILSAENRYKIIEYISHLPCGIFGYLSVTREREKIKNLHCSYCEGKKLVQSSILDQQDFENTSNQIIATFAKIIKTNVFSESKRCRVLTMMAIRKLALHFDHPSFLDLEVSELAQWCFQSLTSSIRELRVAASRTVTAFLSGSSSDSVTRKNRSCALEILRRFPSDQGIHLQESCVLTWGQIGRIVMDDELNIVLLALVQYLGHGNPIVSGVAFNEILRLAKALDLSVSRLFSPFWGTVANEAVKNLIIKPTTTQMMADLLQINVNEFLLLTQSYTIPWLVMGKKIDVIRKISEARKDSEIGLACAESSNLVPTLSLLMIQGMPDTENYIMSHLRYASPRFKNTDLNELMRVEPASQALYLLKAAGEAHDDKKIRIHFALKFLAERARIPDTKSKDSDPVGVFLEQHILGLITNISAVIIDTAHEQSITEKKRNIKALEELVKVAKAHSRIGRPQICACLQLALSQKELQASAFSAWATMLSNLDDEDVEAMLESTFSTIVQHWKYFDETTQRLIEDLLQYLLRERSKNIRNMIENLPSLTECPRLSKIESQLEKMRIPTDVGNAFRIFSRRIGHENPCVVTQALIELKSYLRLNQSFIQSSAVSEQPDTFISDLVRSILDTCVKFNNSDRHIALLSAECIGLIGCLDSNRVESIRDHREMVVISNFEDEDETLDFVLFLLQEVIVPAFLSATDTVLQGFMSYVMQELLEICRFKEVCAPIINGDNKSSSHHIYLKWASLPGTIQDILTPFLTSKYSLKAMEPIAFEYPIFRPGKIEKTLSNKQSSLYTPWLRNFVLNLLGTPLTQAAKHIFPPLCRAIRIKDLSIAGFLLPYLILHVIVAGDEKQRQNIGSELLAVLIYKLPNDSSVPREDFELCIEIVFRVLDYLARWIQEKRNKNSRNSIDDDSISRIQSVTNMISPEIISDRAVDCKSYSRALFYWEQHIRDIRNNDKRQETKTALFERLQDIYNQIDEPDGIEGISAHLHVLDIDQQILGHRHAGRWTAVQSWYEIKFAEQPNDINIQLNLLTCLKESGQNDVLLNYMQGMYYTNETIPKLLPFAIESSWATGRWSTLEKYVSMTTHSIAEDFNVSIGRVLLALRRKEKDKFQLGIQKIRERLAQSLSFATTSSLRVCHDTMLKLHVLTELEIIAGTDSKSPIIGNILRTLNDRIEVLGAYLNDKQYLLGIRRAAMHLSSLNFSNYDIAASWLTSARLSRRGNASHQSFNSVLQASKLGDESATIEHARLLWRDGHHRKATQSLQGAIESNAFITHNKNQNDTKFDDFDISEQQNLLTARAHLLLAKWLDSAGQTQSSTLRTQYQLAAKTHTNWEKGHYYLGRHYNKLLETEKKLAPELQNEQFLIGEMAKLVIENYLRSLSHGTKYINQTLPRILTLWLELGTQVILPLDTKYGNSKDFVTRVTSLQKKNLEQIHSRILKYSGKLPAYIFYTALPQIVARIAHPNQEVFNYLAKIIYRVVDAYPQQAMWTLLAVCQSKQQDRKARGMTVLQFIRAGKKSAPGVIDIKSLIRNGEKLTNDLLQACEAGDFHGSRTIWCSLSRDLRFHSRSCLPSLMAVPVESVLTATLPTLTENMKAHKAFSRDIVTISSFSDAVMVLSSLQKPRKLLARGSDGRNYGLMCKPKDDLRKDQRLMEFNGMINRSLKRDAESSRRQLYIKTYAVTPLNEECGIIEWVDGLKTSRDILLHLYKARGISPNYKEIESLCEEACKSGGKISFFTEKVLGAFPPVMYQWFVSQFPEPSSWFTARLRYTRSCAVMSMVGTILGLGDRHGENILFEEGNGGIFHVDFNCLFEKGLTFAKPERVPFRLTHNMVDAMGVYGYEGPFRKSSELTLKLLRQHEETLMTILEAFIYDPTLDLLSRKSEKKKKAHAISVPDTAQGVLNSIQRKVRGLLPGESVPLGVEGQVDELIKQATNPLFLASMYIGWCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAX3</accession>
    <name>A0A0B1PAX3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0390</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000418">
        <property type="protein sequence ID" value="KHJ35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAX3"/>
    <dbReference type="SMR" id="A0A0B1PAX3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAX3"/>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059021" description="Endoplasmic reticulum chaperone BiP" evidence="15">
        <location>
            <begin position="36"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="673" mass="73721" checksum="FF7D80AC3DE67EBC" modified="2015-03-04" version="1">MVSSSRRSSLLIGISSVFYAFLLLFPLALLGPAQAADQAPLQESYGTVIGIDLGTTYSCVGVMQKGKVEILVNDQGNRITPSYVAFTDDERLVGDAAKNQAASNPKRTIFDIKRLIGRKFEDKDAQADMKHFPFDVVQKDGKPNVKVEVSGSFKTFTPEEISAMILGKMKDVAESYLGSKVTHAVVTVPAYFNDNQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKTDGERQIIVYDLGGGTFDVSLLSIDRGVFEVLSTAGDTHLGGEDFDQRIINYLAKKYNKENNVDITKDLKTMGKLKREAEKAKRTLSSQKTTRIEIEAFHNGKDFSETLTRAKFEELNIDLFRKTLKPVEQVLKDAKVKKSEVDDIVLVGGSTRIPKVVELIEEFFGGKKASKGINPDEAVAFGAAVQGGVLSGEEGTEDLVLMDVNPLTLGIETTGGVMTKLIPRNTVIPTRKSQIFSTAVDNQPVVLIQVYEGERTLTKDNNQLGKFELTGIPPAPRGVPQIEVSFELDANGILKVSASDKGTGKSESITITNDKGRLTQDEIDRMVQEAEKYADEDKANKERIDARNALENYVFSLKNQVNDEKGLGAKIEESDKETILEAIKETTSWLDKNGSEATTEDFEEQKEKLSSVAYPITSKLYSNTGGDDNKGEKDEPESHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB63</accession>
    <name>A0A0B1PB63_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative arginine permease can1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000807">
        <property type="protein sequence ID" value="KHJ34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB63"/>
    <dbReference type="STRING" id="52586.A0A0B1PB63"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="MFAYLAV"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="37"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="533" mass="58411" checksum="A72EE5F95728C300" modified="2015-03-04" version="1">MAITSSTIFDGSSEGSKCIEVNVEQQPELKRRLKARHMQMIAIGGTIGTGLFIGSGSSIATAGPVGALLAYTIVGTIVYSVINSLGEMATYIPITGAFTAYATRFIHPSLGFAMGWIYWFSWATTFALELTATGLVIQYWAPYLDIGIFIGVFWLLLTVINFFPVAIFGEFEFWLSSVKVVTVVGFLLFAICIDAGAGQNGYLGFSTWKNPGAFAPYLITSSPALGKFIGFWAVLIQAGFSYQGTELVGIAAGECENPRKNVPAAIRKTFFRILIFFVTSIFFIGLLVPYDNKSLLSGASDASASPFVVAAKLAGVKVLPEIINTVLLFVILSAANSNVYSGSRVLLGLAADDFAPEFVTRTSRSGVPYVAVALTSGFGLLAFLNESDQGGYVFNWLMNISSIAGFIVWACISFCHITFIRVLAARNIPRHTLPFCALGGEWFAWYGLLFNLLIILTQGFTSFLPWSATNFFTCYISIMLFVMLFFGHNIFMKTRFVKLSEADITTGCIDSNFEVWNDEKAETRWGRFLQWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB77</accession>
    <name>A0A0B1PB77_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000370">
        <property type="protein sequence ID" value="KHJ35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB77"/>
    <dbReference type="HOGENOM" id="CLU_1273089_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079892" description="Secreted effector protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24388" checksum="E3E118233C65C401" modified="2015-03-04" version="1">MKFFAIAKATLIVASNILVFGFQQQNGNSKVSKINLQPSNIYVKCGSISYTSEELDKAAAQACPLMTGKGKFLGIRWKTKPTVYQGTLLAKSEQNSLNTNSNDYKTKFLNFDHHPLLQWPLANKFKYLKANCYAIIKWDPTRVKCKVIGAYWKEKNREDVKCEQLTIRDKNSRYAASPIYHPGAPNSVHRPSGKSESVHDTTSIPPFNSNLHSSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG7</accession>
    <name>A0A0B1PBG7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001106">
        <property type="protein sequence ID" value="KHJ34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBG7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBG7"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="89"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="401"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="12">
        <location>
            <begin position="507"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="620" mass="71037" checksum="2E20C8F1E437C6D9" modified="2015-03-04" version="1">MANNTEGMAKLQLDEVTGEFVSKGELKKRIAKRTKKAAAAKAKANAPPKDLETAQDKTKIEKNANIESTNMFAHGWLDEVFKERPIKPVVTRFPPEPNGYLHIGHAKAIAINFGFAKFHGGICYLRFDDTNPEAEEEKYFIAIEKLIEWLGFKPFQVTYSSDNFDKLYEKAEELIQRGKAYVCHCGDTEIKAQRGGEERGPRYRCAHADQSVEHNLTHFRAMRDGKYKPKEAFLRMKQDIEDGNPQMWDLAAYRVLDAVHHRTGTKWKIYPTYDFTHCLCDSFEKITHSLCTTEFIQSRISYEWLNKTLEVYEPMQREYGRLSIAGTVLSKRKIMKLVNENHVRGWDDPRLYTLIGVRRRGVPPGAILEFVNEIGVTTAPTTIQLARFDQTIRKYLERTVPRLMLVLDPLPVYIEDAEEMLLEMPWSPKIPEMGSHKVKLTKTVYIERADFREIDSKEYYRLAPGKSVGLLQIPYPIRAVSFTKENDQITGVKAVYDKEGKKPKTYIHWVPEGSKNVEVRIHQSLFKSEKPDNVEGGFLNDVNPESEKIWPGAMIEAGFDEIRARAPWPKTAGELESSKAGVESVRFQAMRVAYMTMDIDSTNEKIVLNRIVGIKEDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBQ2</accession>
    <name>A0A0B1PBQ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 20s proteasome maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000131">
        <property type="protein sequence ID" value="KHJ36132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBQ2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBQ2"/>
    <dbReference type="HOGENOM" id="CLU_100687_0_0_1"/>
    <dbReference type="OMA" id="MSMRIVP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="155" mass="17190" checksum="0305323D08B4E7A6" modified="2015-03-04" version="1">MRIVPLPNYPTKVSDLDTKFTGAPSAPSVKDLLRTGLGPTFTPSESATLSEPPVSNHPLEARIKKWEETQEELKMEGLRRTFGIAEPIRRGMELKIVREGSWKPACLGGGLGRSLHEDILMGTDTGCQWEDVFKGDVSRNILGFHEEVERKLGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT3</accession>
    <name>A0A0B1PBT3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000892">
        <property type="protein sequence ID" value="KHJ34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT3"/>
    <dbReference type="HOGENOM" id="CLU_033344_0_0_1"/>
    <dbReference type="OMA" id="PFRWKHP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="40475" checksum="75B0CCC71558AEE4" modified="2015-03-04" version="1">MVQDSTSNGLLPNSPLMDENFHEARQRYRQPKLCRDTTLTPLQQAVRKNFYARALATPLRKCRLTGVIMPRFFLLDFIAIANPATGIPWYMPRSLTSKVSLSANINQQKDFPQEISSTSTSLSKKNQKATLLAKDGCEDTDTLIDYDLNLTKVPEKYTQSESSTPRIGGGTYLLRSYHAIDSICNKSNKASKGVISQHFLTQNIRNHPSALETFQKTCFRSDMAKFVLTLKRRRVNEALILVTSKFRGYITKFNPTKSLKTSQVTAILLLGPPPTAECEGQVISEKEFRTYMQKSPVDVPIFDLRVLLGDEMLQRLRNSDPKRWNSEVLTIKNKNYSQPLLTRLWELEGYLTPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBX3</accession>
    <name>A0A0B1PBX3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g6476</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBX3"/>
    <dbReference type="SMR" id="A0A0B1PBX3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBX3"/>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="479"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ35743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="860" mass="96889" checksum="923EEA92EE60D446" modified="2015-03-04" version="1">MSFPSRGAGPNRVGHKRARELDESELGTSPLPSNFRSSPPVYPVNHGFDDNDDDVEEEIALDIDDVDEMIDEEDGIDLFADNFERDYVNRDNDQYEGIDIDDADYDDLDLAERRKLEARLNRRDRELARAQRMPAAFLLDEGDDGDVDLSVQPRRHRHHYDEDDEMEDDIMDEELSLETLQDVKASSLVDWVSQQAVQRSIKREFKAFLTEYVDDHGVSVYGERIRTLGEINSESLEVSYDHLTSSKAILAYFLISAPGELLKLFDEVAMDVTLLHYPDYERIHSEIHVRISHLPVNFTLRQLRQSHLNCLVRVSGVVTRRSGVFPQLKYVMFDCGRCGARLGPFQQESSVEVKISYCQNCQSRGPFNLNSEKTVYRNYQKLTLQESPGTVPTGRLPRHREVILLWDLIDKAKPGEEIEVTGVYRNNYDSQLNSKNGFPVFATILEANNVIKSHDQLAGFRLTEEDERRIRLLARDPHIIDKIITSIAPSIYGHKDIKTAIALSLFGGVAKDRQGKHHIRGDINVLLLGDPGTAKSQVLKYVEKTAHRAVFTTGQGASAVGLTASVRKDPLTGEWTLEGGALVLADKGTCLIDEFDKMNDQDRTSIHEAMEQQTISISKAGIVTTLQARCGIIAAANPIGGRYNSTIPFSQNVQLTEPILSRFDILCVVRDTVDPEEDEFLAKFVVGSHSRSHPSQIKETQNISNESEEQSSGQRNQSKKDDGINQELLRKYILYARERCNPKLYNIDEEKVSKLFADMRRESLATGAYPITVRHLEAIMRISEAFCRMRLSEYVSSHDVDRAIAVTIDSFVGSQKISCKKALARAFAKYTLGRTGKGKKSSRGTNLEKRARNLGTVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC12</accession>
    <name>A0A0B1PC12_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0155</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000840">
        <property type="protein sequence ID" value="KHJ34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC12"/>
    <dbReference type="STRING" id="52586.A0A0B1PC12"/>
    <dbReference type="HOGENOM" id="CLU_028200_6_2_1"/>
    <dbReference type="OMA" id="FACITTM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059052" evidence="15">
        <location>
            <begin position="18"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="424" mass="47810" checksum="3E47F6EAB8ED705B" modified="2015-03-04" version="1">MKLLWCLSFFFIWAGLCLETPDRTNATSPTPSCVTSCFVENVFREAKCDINQVAQCLCTNIALQHRLSTCVQTSCNFEEQGIAINEQAKLCAGYPQESRKAYIMKVGIIFFVITMIVLGCRLYTRYSNTGKLWADDWVALVAGICLVIVASLEIYVCNLGFGKHIWQIPITKGLQLIKPFYALQFLYIVVQVLAKISLLLIYQRIYPSSKFQLICTIGIAFVATHGLAFIFTIFFQCKPIRSSWDPSMNRNCLSAPAIGFAGAGFSIVEDLVIIFLPLPQLLQLQIRTAQKVALIFMFSIGSFACITSIVRLKYLSTFENSTDLTWENTDILVWSILEIEVTVICACLPTLRPLFVEIIPGVFRTAKNTSSSSRITNSNSILKPKLTKFTYDLNPRNWLRWKNKHKTESEKLPVCEKSWSSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ4</accession>
    <name>A0A0B1PCJ4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01000539">
        <property type="protein sequence ID" value="KHJ35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ4"/>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="45666" checksum="816D6208F41646BA" modified="2015-03-04" version="1">MPALSPTMTAGNIGAWKKKTGDSIAPGDVLVEIETDKAQMDFEFQEDGVLAKILKESGEKDIAVGNPIAVMVGEETDVPAFESFTIADAGGEKSNNISTGDTKKSSEPSGDHSHTSAKDSALLSAPEETEANDERLQPALDRVLNATASAVRLAREGSIDISTIKGTGNHGQITEADVRKASPNIISSTAQSSVNYVDIPVTSMRNTIANRLVQSVNQNPHFFVAATISVTKLLKLRNALNESSGGKYKLSVNDFLIKAASVACKKVPTVNSSWRDGFIRQFSNVDISVAVATPTGLVTPIVKSVETLGLASISALVKDLGKRARDGKLKPEEYQGGTFTISNMGMNPAIDRFTAVINPPQAGILAVGTIKKVAVPLEAESTDDVNKFEWDDQIVVTGSFDHKVVDGAIGGEWIKEFKKVVENPLDLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY7</accession>
    <name>A0A0B1PCY7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g0016</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="JNVN01000830">
        <property type="protein sequence ID" value="KHJ34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCY7"/>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OMA" id="FNWYNTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080639" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="41"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="305"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="819" mass="94096" checksum="480958DA49114140" modified="2015-03-04" version="1">MLILHIIVALASIAFAQATKNDSVSKEEFRKNLSKINEAYLWGSYRPNLYFGVKPRIPQSFIGGLMWARVEDYASVQDHLRHTCEQSDNIRGYGWDEFDARIGGVQNIYDEGNGIDISIKFVKIPGGGNGGSWTARIQGTLRKDSHSDMKSTVIFYAALEGEGSLVVDNEVDRLGFKDDVTIVGDSPQLNKYKLTVSRGSGEHPFIEHEASRLKPLDRTFVSSITASKEVIWESKTLVFKEIREQVDLYLKEYGNQNLPPPAQMYTVPQKPGVGNLHFIQKVFQGNFEFDVVFQSESSGEEFDHDKITELIEKNSKAYWQQFDAKFKLQPPFDTNQFQKCASSLFSNLLGGLGYFYGDSLVDRSYASEYEERNEGFWKETADARARKLEKLEGPSELLTMVPSRPFFPRGFLWDEGFHLIPIIDWDLDLVLEIIQSWFTLMDEDGWIGREQILGPEARSKVPSEFQVQYPHYANAPTFFIVVEILIAKFEALNNNGGANGTYIPKLEEDSEYLRSPELAQQFFRGLYPKLKKHYNWYRKTQVGDLDSYDRIAFSSQEAYRWRGRSEQHVLTSGLDDYPRPQPPHPGELHVDLLSWIGMMSKSLQKTASFLGYLDDRKEFEANLNAISHNLDDLHWSKELKCYCDATIDEYEEHTLICHKGYISIFPFLTGLLEPTSDKLGPILDLLSDPNELWSEFGIRSLSKNSEYYGTNENYWRGPIWLNINYLTISQLLRYAQSSGPEQQRARKIYGQLRLNLVKTVYESWLETGFAWEQYNAETGKGQRTKHFTGWTSLTMKIMAMPDLTGDSLKLNTQRHHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDC4</accession>
    <name>A0A0B1PDC4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nuclear pore complex subunit nup159 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000094">
        <property type="protein sequence ID" value="KHJ36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PDC4"/>
    <dbReference type="HOGENOM" id="CLU_003852_0_0_1"/>
    <dbReference type="OMA" id="RGQCASI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000645">
        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="50"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1333"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1472" mass="162049" checksum="9C97052C086959A0" modified="2015-03-04" version="1">MDFKSGDYNCSAQIGPPIEDIQTEAIGFLAVSGETKVQLLPEPWPKDNLPPPTASLMSIASRAGLLAAAGPEGIILASTESLRKSFCDSQLQNGQIQRFEPQLKIPMNFRISQVAFSSDEKFLILSAEIGGGLAVYEVSSVMNGSQQSTFELSTNGKALRALMPNPAPEKAELLAIITIDGNLMVANLRDRNFIVGAQGFVLKECVSSMSWSTKGKQLVAGLGDGTACQMTPEGGLKTVIPRPPDNSTDHHISSILWLENHMFFSIYTPSSYDPNQAPHANLYLTTRTADCKNYTFQKITDPVQPFGLNRSPPHHFMLRLKDFPPNLQDIIIMASTASTDIGLMTRSKVPLTKDKPPEKICGVFTMTELSDDSRRAQLPFSAQLGDTSPIGFALDLSSRENVHRPIPGDEILESSSPAPALTLLNNEGVLSSWWVIYLDSVRQKTTYPGLALKSESNTTSLTKSSGPFGGAETLITTNNKSPFATQSFTSVLGAPRSTTVTGSSPQVTSGSIFGTSSALGAQKSAWGSSLGQNAFPSSTPEFGKPIFGSNQSTPSMTSLGAPTFGKPSIPKFGIQNSVWTNSTSDVSTKVMGTNAGNEEVTSVQRPLTFGVGETKIASSGFASFASKNEFGRLLNQSSTMESVLKNNSQSISSSNTSHNVDLIQNKEKTSTSIFGLGSTSGFVLGTTFKSDLPVDNHGSSIEPDKQYGLFGKGFANELISNAVLSDSNNTSEKTQDNSTEKLEDQKMDLSEPISNLSSNLTSAKMPLFPSLFGSQSIIKSSNSLNNEASKDTEDRINSTSQSKAAMNFRQTTLLGNSDIDTRNVLDRTVEQESPAEKTEIQGLDLASTTVKAKSKLNQELSPESSYEIIENNDVIETSKSENPTQPGLLFGEIRPCNEKDIVPSLSYDQITDSDKIKSPESYQNLKNSNVISQPLVCDEIDKDTDKTVITNPTNLVRESCDSHIEEFSLEKTAPNNEVEKKCDKDVNEVEKVFQAGAKAKEQVELNLEPEILAEKEAELKRHYDVVAEREAEEKRRNEIVAQRKVEEKLRNELIAQREAEEKRRNEIVALRKAEEKRHKELLARWEAEEKRREELKIQKDAEEKQAIIDSDDTCMQKFLASDFEPTTRLNDFVAHSDYVSTLTVESIPAQVEAVYRDINSMIDTLGINARSLHEFILGHTREQNTKKLCRNNLKDESIWTLGEIQSLTSIIDNELSYDLEKSHIKNFEEKLENCKELQKDLIKLRAKHVDIKKIIATNQDPNCIAIARAQPLGVKQATQQHELRRNFIKFQRLLSEAEEAIVVLKAKIVAHTAMNQKSNTPVGPTVEAVMRTITKLTNMAEKKSGDIDVLENQLRNLKINLSTSCIGYRETPTTPTNQHKFLHRNPAANSFSYGSFTPDHIKTSPNQNLFLSSVGSSGRQVSSSPRRTLTGYSAEEKARLRYLTDKKISVKNRLRQACQNLGVRVRVIDSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD7</accession>
    <name>A0A0B1PDD7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD7"/>
    <dbReference type="HOGENOM" id="CLU_142986_1_0_1"/>
    <dbReference type="OMA" id="RFFRRCK"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="86" mass="9797" checksum="5E42EC844D1362B3" modified="2015-03-04" version="1">MAPFISTIPVSDLALNAQLRTNERKHSGYGGNFDKCELLEMLQYTCEVEGDKVVCRPVERLFRRCKDKNRGFLVETTALEKKSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDE5</accession>
    <name>A0A0B1PDE5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1078</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01000429">
        <property type="protein sequence ID" value="KHJ35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDE5"/>
    <dbReference type="SMR" id="A0A0B1PDE5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDE5"/>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="407"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="407"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="541"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="586"/>
            <end position="588"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="678"/>
            <end position="681"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="775" mass="84657" checksum="D789ACD4FBEE6D5F" modified="2015-03-04" version="1">MTTTQLSSPSTVKKRRIAVMTSGGDSPGMNAVVRAVVRYTIKSGCEAYCIYEGYEGLVRGKDLIRKMDWSDVRGWLSEGGTLIGTARCMSFYERSGRLLGAKNLILNGIDALIICGGDGSLTGADKFRAEWPSLLKELVQTKDLTQEQVNPFQYLNIVGIVGSIDNDMSGTDATIGCFSALSRICEMVDYIEATASSHSRAFVIEVMGRHCGWLALMAGVATGADFVFIPEKPVAGNWRDEMCKNVKRQREFGKRKTIVIVAEGAQDSQGIKILPEVVKDLLADKKGLALDTRITTLGHVQRGGKACAFDRYLATLQGVEAVKAVLEANPETPTPLIAITENKITRKPLVKAVLDTHEVSKAIKAKDFDRAMSLRDTEFFDLFNSYVTTTSMGHNSQMQLPSQKHMRIAFIHVGAPAGGMNAATRAAVAYCLTRGHTPIAIHNGFAGFARHHGDKPLGAVRDFDWLEVDGWASRGGSEIGTNRELPLESGLDYIASLFELYKFDGLFIIGGFEGFHALSQLRIARSKYQSLCIPMTLLPATISNNVPGTEYSLGSDTCLDELVRYCDTVKLSASATRRRIFVIETQGGRSGYVATLAGLAAGASAVYIPEEGISIDMLAADIKHIKNLFKQDSGHSRSGKLILVNEKASPVYSAKLIADIIRNEAANRFESRDSIPGHVQQGGIPSPMDRTRAVRLAIKCIEHLEKYEGYSNTEILNDPLSSSVIGIKGASVVFSSMKEVEENETDWPNRRPLHETWLKHRQIVDTMAGRPSGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDF0</accession>
    <name>A0A0B1PDF0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000089">
        <property type="protein sequence ID" value="KHJ36263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDF0"/>
    <dbReference type="HOGENOM" id="CLU_1125233_0_0_1"/>
    <dbReference type="OMA" id="ESAMSGM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="22727" checksum="D74DB62C67B68776" modified="2015-03-04" version="1">MDLLETLDDLGISGSVNTANSPDGAIMGSASGSIGGPIGEIISSVFGGGPVAGSVSGSVGEQISGTAKGSVGQLAGSVSGSVGQPAGSVNGSGPGLSSNASTTTSTGASADASAGASLNGSTGASMNGSTNASTGASADASARASLNGSTGASMNGSTNASTDASTSASKNGSISASMGGPKSAPTGATKLSAGAKEVQKESAKSDASNSSGNGPSQGKNDTSGAAEISRIGALLTLAIMSIAVLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDF3</accession>
    <name>A0A0B1PDF3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000592">
        <property type="protein sequence ID" value="KHJ34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDF3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDF3"/>
    <dbReference type="HOGENOM" id="CLU_023880_2_0_1"/>
    <dbReference type="OMA" id="IYPAAWM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="564" mass="63391" checksum="5B37F5848A4F0FC7" modified="2015-03-04" version="1">MSMFGGQNAENITEAQLLKAPQACMSCRKQKRKCSKTLPACALCHRMGRHCDYSDSAPAPTSEDFHALRMKLTELESKLKYSQRGFGTSFTNNGLYGGLFMQGEQIGQLHQVSGFSLPRELPWLGVQNKFPSLAFLHGLAFRSAGIAAPRPNFNTPSDIIELLGSGLNIEIIMNNYFLSIHQWIPILSKKRLTRYLNKPQWEFTPDFALLYLSIKLLISKPKDGIDCSQNELYLAAKRFINLMQSTGFISILVLQANILITLYEYGHAIYPATWMSSGWSVRYGNLLGINGDKEAIDLLGKPGDEIDQEERLRAWWAVLLIDRIISISSMLYITNSQEPKGEDMLPIDDDAWERGEILSAPRMTVSTPIAEHLSSFARLCQIHVLIGQIMLHLKDKSVSEPTRFTKATKLHADALELVRKIKDESLASKNLFSLISPLALTYSSLCILCSPYSSISDEANEGKNQMRKQAIAGLDTVAVNIIDFVDQVNIATQTLQDLDRVSPFIMNAIYAGSLTLTRLHRENSEESYQASLGPLRQCLKKLSTRWRIAADYLRILEVHEFAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDI9</accession>
    <name>A0A0B1PDI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000741">
        <property type="protein sequence ID" value="KHJ34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDI9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDI9"/>
    <dbReference type="HOGENOM" id="CLU_007327_0_0_1"/>
    <dbReference type="OMA" id="WSQVMYW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="402"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="829" mass="94008" checksum="BA131E66A8F49E24" modified="2015-03-04" version="1">MDNFTSTIVGHESTVENDGLGGDFNIGIGEADQRPNKLPDDLPKSLDDRKFTSSYTFETEIYDAWKGQSEILRPAVPARPLQYRSLSIDYGSKIPILKPTVNNHRLTNMLAAQAAHRDVFIDGDEDSIANNDNLSDAEKKKTLQKSLNMAASNGDIDRIQCILNGKAKEYVDINAPDEEGTTPIIYASCFGHEAVVNALLDAGAKADSQDQNQWSALMWAMINRHKRVAKALLDRGASVEVRSASGRTALDFITPNSDLSEFLQDSGYNIGNVGVPDDFYNPGFSQDRFEEEVAENEMRRRMMMESARDLEVDIGNVGFDDQPETPEEHGEEALEFDWNRCLHDQMFVFQENELGRILNIVITTMTPQRSSSQKPVPANILFLSARYAHYHANQDLLAKLLITSLEKINDVVESHQWDMTILAFWISNATLLLHYLKKDGGLSVSTSDFQFQLAELINEIFILIIRDAERRIDKTLDSSMLDHETIKGLEDIAFQHEWKIFKRKIQVKEEPAEKRFRPPSPKARSKPSPRNVTSLLSSTLFVLDLYDIHSVIISQILAQLLYWLGAELFNRIMSNRKYMARSKAMQIRMNLSMIEEWARANNRLPEHYEDGSMTSTGESTIDAARNHLAPVIQLLQWLQCFSSLEQNDLDALTGTVQQLTRLSPQHLIHVVKHYRPEVGEKGLPKTGIKYLNKLQKQWQERKDRQKNLRRASSVSQIATSKTANNNYRFSQDSERAQQARNSGNVALGSIEEEDAPEGLFLDPAIMLPFTLPSGTDMLVRYGAGFGGLNRERERKYIPTISPEFLAKLDANGDKSRLRYSEKEWENEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEP0</accession>
    <name>A0A0B1PEP0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEP0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEP0"/>
    <dbReference type="HOGENOM" id="CLU_012712_1_1_1"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="48263" checksum="1945BDABF2A49DCE" modified="2015-03-04" version="1">MTTQSLLSSSPSIKIPLIPLNYSSDESHQSALRIILALRPNWKNGQIEFIRFTDGTTNTLLKVINKLPELSDVEIDNEAILLRAYGPGTELIIDREQEAQNHELLMQYKLAPELLARFHNGMLYRFLRGSVTSTTDLRKQEVWLAVARRLAEWHAVVPCIQNIDGKSNNYSEQYSVYQPISNSIVTELPKIPHLTHLENIQPNLWTVLKKWVSAVPTNTIAEKSRQQILQKETDRLILELSNRLGLGKNSLVFAHCDLLSGNIVMLPRSTVDANATLTVSFIDFEYATPSPAAFDIANHFAEWGGFDCDYHQLPTQSQRIDFIREYIKSYYRHLNHKISDEDREAESKRLFSEVDLFRGVPGLYWGVWALIQSKISKIDFDYASYAEIRLSEYWDWRAEHDGTRAASGGKIPLREARWAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF31</accession>
    <name>A0A0B1PF31_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sam binding domain-containing protein containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000367">
        <property type="protein sequence ID" value="KHJ35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF31"/>
    <dbReference type="STRING" id="52586.A0A0B1PF31"/>
    <dbReference type="HOGENOM" id="CLU_013481_1_1_1"/>
    <dbReference type="OMA" id="WETDHII"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="457" mass="51932" checksum="078C16FFB2CC93C6" modified="2015-03-04" version="1">MLHTPLSDFKSSPTLSIVAKRAYHHRRDSSERKNAVEIHEARQATSSRGTTASGLQRSMSIRSSSISKFSGTPSNKKVLTNEYSAQPYILKNGRRYLRDVTLPYPLPCDLTEIHRQTLRTMLLLQVFDGPLCSPVSQKMPPKRVLEVACGTGYWSEMCHRHFSQQGIKSVSFTGIDIAPPAIPLETLENSSIDWHFVQHDLRQVPLPFKDEEFCIVMVKDLSMVTSMTDMEQKLMDEFLRILKSGGTLEIWDGDHSLRMLLPHSQVVNEEQDKNLQEETVSRCSKGIYLVTPDTSFAAPKNPYLSEYNLWISKALGSRNLTSMPCTTILSFLIQESESLQDINSRRIAIPLDKVRWENEHSTKKKATSDFTSESKVKVPEKNFSNATQMAIRRTALMTVIQMIESLEPLLREASGKDPDEWDYWVESMMSDLLQGNGASWGECLEVGAWWARKNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF45</accession>
    <name>A0A0B1PF45_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative gtp-binding protein rhoa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2787</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000199">
        <property type="protein sequence ID" value="KHJ35940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF45"/>
    <dbReference type="STRING" id="52586.A0A0B1PF45"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21740" checksum="7F925563BF24F71E" modified="2015-03-04" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHIILICFAVDSPDSLDNVQEKWISEVLHFCSGLPIILVGCKKDLRYEPKTIEELHKTSQKPVTPEQGEEIRKKIGAYKYLECSAKTNEGVREVFEHATRAALLTKKKKEKRCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF61</accession>
    <name>A0A0B1PF61_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphotransferase enzyme family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000187">
        <property type="protein sequence ID" value="KHJ35955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF61"/>
    <dbReference type="STRING" id="52586.A0A0B1PF61"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="OMA" id="RAFYVME"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="336" mass="38584" checksum="1CB57904539EC74D" modified="2015-03-04" version="1">MVESVRQQIDVRSLENYLTKKLDQLKTPISLKQFNFGQSNPTYQITSSDFSKYVLRKKPPGKLLSSTAHQIEREYRILRALEKTNVPVPKVYCLCEDDSVIGTPFYIMEFLDGRIMEDPDMPGLLPNEKEEMSGMMLFYDRQIKTFNKVCQVQAEIKDIESHEKVGPIPYMKELLLYFSDEYIQPQDRSSLIHGDFKIDNLVFHKTEPKVIGILDWEMATIGHPLSDLSNLITPIRVETQSQAKISELFSIDTKKDLARLYANTVGWDPTPDLNWGLAFGLFKLAVILQGIASRYALRQASNAKAKEMAKCRHHAAQLAWNQVQINIENSRKKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF90</accession>
    <name>A0A0B1PF90_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000348">
        <property type="protein sequence ID" value="KHJ35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF90"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="36538" checksum="2F10703EE45DD47B" modified="2015-03-04" version="1">MGTDSNRKALDESQNLPKTAQMEKNTWATVARAGFALSPCSAEAREQILKAENSLFLSGAKLETATNWVSERVPTVPAFVKMEQGVVEVSKDMLSDKIERVSSMRPAHLKLYGRNNLKVPHRTWLAYFPKAPRRGFRVFDESRMVRPYKKHQPIEFCKRCNGHRPSKNCSRAPSCANFRSTNHTADNCMATTKCRNCGGPHRADSRRCLACPMRSSAPTKEQLKTYRQMREREYNAVQRARVAEEKAVSIDKTEIDLTSSQASKKNMILDNSQAIPVEDTTVVSERTKKYLSFDLRLSFDGQRIWPRAATYIRKLEKNRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFG8</accession>
    <name>A0A0B1PFG8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000158">
        <property type="protein sequence ID" value="KHJ36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFG8"/>
    <dbReference type="STRING" id="52586.A0A0B1PFG8"/>
    <dbReference type="HOGENOM" id="CLU_058251_0_0_1"/>
    <dbReference type="OMA" id="IDDQTWF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33377" checksum="42EBF789B66C1F3A" modified="2015-03-04" version="1">MVILSPRIQFYEIADQKWFPRYLREKFQSCLAACWNIRLPLLQKSSPAQLVAYTLFQVLDDARKYRFVDFCAGAGGPTPTIERELNSKLSSRYSSTEKSKENNAPVQFLLTDLHPHIPEWTKISKQAENITFIPESVDATCAPSSVKSNDEQKVFRLFNLSFHHFDDNLGSEILRNSLETADGFGIFELQDRTPSSLIMMMLLGLFLFIISPFYFWRSPGHIFFTYVIPILPFVVVTDGYMSSFRTRTPEEVLDLLKNCGASPEDWRILSGREQHTWPIGNMSWIIAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFM1</accession>
    <name>A0A0B1PFM1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial oxaloacetate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000424">
        <property type="protein sequence ID" value="KHJ35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFM1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFM1"/>
    <dbReference type="HOGENOM" id="CLU_015166_14_3_1"/>
    <dbReference type="OMA" id="GFYDPMR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034658">
        <property type="term" value="F:isopropylmalate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901239">
        <property type="term" value="F:malonate(1-) transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015131">
        <property type="term" value="F:oxaloacetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="306" mass="34043" checksum="2D19F92287F6B97C" modified="2015-03-04" version="1">MATSIGAFIAGGIAACGAVTMTHPFETVKIRMQLQGELKQKKAHLRVYLGPLHGVKVIVRNEGLQGIYRGIGGAYLYQMILNGCRLSFYEPIRRQVTTLFYSNSETQSLPVNIFAGSISGVMGAAAGSPFFLIKTRLQSFSLFTPVGTQHKYRNTIDGLRQVYFAEGIYGIYRGVNAAMLRTSFGSSVQLPTYFFAKRRLVKHLELQEGPTLHLISSGISGSVVCCVMHPTDTVLSRMYNQNGNLYRGVWDCVVKILKTEGFWAMYKGFLPHLTRILPHTILTLSLAEQTNDLMRKFETNVLQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGB9</accession>
    <name>A0A0B1PGB9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000085">
        <property type="protein sequence ID" value="KHJ36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGB9"/>
    <dbReference type="HOGENOM" id="CLU_1210570_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="229" mass="26217" checksum="EC63BAE198E3DD10" modified="2015-03-04" version="1">MISDQRPAPEVWNSNKEDNFEFKLAIFHDLFERSRVLAYMRSQAYPTMLRGLALDHYYENIESNKKTNFEIKCLATSQYFEGPEYKRKILTKWNGISLNSIKDLNVDKTARGCLQILTKELRHLQHGLDHDLRTDKSLHNKLINACQKVPACQLACFKPNSEGITKQIDNLILDVESLSDVKDITENFLTSLGPIVTVMRGPVTKTAQHIITKSLGRQSRNLHLHAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGF4</accession>
    <name>A0A0B1PGF4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative amino acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGF4"/>
    <dbReference type="STRING" id="52586.A0A0B1PGF4"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="TSRHIMM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="66"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="563" mass="60917" checksum="39BBFF7595C9226C" modified="2015-03-04" version="1">MSKKNNSSLEINKSSSSINSDSKVSTRKPSITKDNEIILPQATSDLDAVYGVGGVGRTQRRLKARHVTFIGFGGGIGTGLFIGTGSALATSGPAGLLMAYIIVGGLLWCVMESIGEMATLFPTAGSFPHIATRFIDPALGFTLAISYGYCYTIAIGSEMTAAAIIVSYWTDITPIVVITIGLVAILIINMCSVRFYGEAEVFSASVKIICFLFLVIISLIITLGGTPKGERIGFRYWINPGPFKEFNGIKGGWGHFLGIFSSFIKASFSFIGVETVVVAAAETLNPHRTIPKAVKRVTYRICFFYILGTLLIGMVVSSNDPALLGSSGDGNSSPFVIAIKNSGIQVLPSIINACILISAWSAGNSYCYVGARMIIAMAVDRQAPQFFSKVNRWGVPYYAVLASFMFGPLAYLGLGSSGAVQALLWLQDMSSLAGLLAWMTLCICFIRYEHACRAQGIDRNKLPYKGRFQPYSAYIGAIGSALIVIFSGFKVFIPGSWSLAGFLSNYLGIIIYIVPYILWKVIKKTKMSLSSEVDLFSGRFDSTHAPVEPIPTTWWGKFVDWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGH3</accession>
    <name>A0A0B1PGH3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000180">
        <property type="protein sequence ID" value="KHJ35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGH3"/>
    <dbReference type="STRING" id="52586.A0A0B1PGH3"/>
    <dbReference type="HOGENOM" id="CLU_044099_0_0_1"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="349" mass="40187" checksum="365A93B598976F9C" modified="2015-03-04" version="1">MERTNKLNHNHNNDDMIVSSRSDAINTISSEPKRPNKRKILLMGKSGSGKSSMRSIIFSNYAAKDTRRLGATIDIDLSHVRFMGNLTLHLWDCGGQDAFMETYLSQQRQHIFSNVGVLIYVFDVESRDFERDLLTYRSIVTALSQFSPTASIYILIHKMDLIIPNQRDNIFADRISPIHSKSEPFSPKPFATTIWDQSLYKAWAMIIHDLVPNLEQIEHNLHTLGKLIMAEEVLLFERSSFLIITKWLSEISVENPTTDRFERISNIIKNFKQTTSRYTGTLRSAEQFILMEIKLSNFSMFMTKFTTNTYLAVILAPGEETFNSAVENCYLARKEFENLDSPIPKRTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGN1</accession>
    <name>A0A0B1PGN1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGN1"/>
    <dbReference type="STRING" id="52586.A0A0B1PGN1"/>
    <dbReference type="HOGENOM" id="CLU_089407_0_0_1"/>
    <dbReference type="OMA" id="KAYRTSA"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="225" mass="25670" checksum="D5F41BCB5E083113" modified="2015-03-04" version="1">MQFFKRYLFPPNFRADYRQYLKMRHFATNNKIGSSNSKPKDNHLTSLNINEIAPWNKLSGKGKVLRATRQTFNVGLIVSGAALSGGVAYLLYSEVFSPDSKTSHFNRSFNQIKKDPRCIALLGNVDTITAYGENGGSWRKSRPFLSINQKDKDGVNHLFIKYNVQGSKSSGTVDLHMTKRDNENEFKYKRLQLDVKGKPRIVLIDADSKPVSKSRRLKVFGVYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGS4</accession>
    <name>A0A0B1PGS4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000159">
        <property type="protein sequence ID" value="KHJ36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGS4"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="86" mass="9582" checksum="4BE30C35CEA4318C" modified="2015-03-04" version="1">MRMRFSQEELAEIIAFRQSRERAWHARFMICTTVISNVDSTLSSFTEDVEKEEVEAFKAYLRLAIANSAAADSPSAPSNIPIVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHA0</accession>
    <name>A0A0B1PHA0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000211">
        <property type="protein sequence ID" value="KHJ35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHA0"/>
    <dbReference type="HOGENOM" id="CLU_2085074_0_0_1"/>
    <dbReference type="OMA" id="TNAPPGF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="12637" checksum="CDBB14C8998D13FC" modified="2015-03-04" version="1">MISIEKSYAAFNRKSDARIGLLQDVIKRIKNGEEVDVESILGTGNKEREQEWQDVLKDIEKDDTSWIESSKQISNSGDSTKYKRNSEKKLNNSLSNSQANNEKIRAPPGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHD6</accession>
    <name>A0A0B1PHD6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative duf300 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000097">
        <property type="protein sequence ID" value="KHJ36241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHD6"/>
    <dbReference type="STRING" id="52586.A0A0B1PHD6"/>
    <dbReference type="HOGENOM" id="CLU_012923_5_1_1"/>
    <dbReference type="OMA" id="HAIYFQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="516" mass="59453" checksum="4D58119DFE8476B9" modified="2015-03-04" version="1">MITPSLDTCNTTLEDLRIGDSESPIISNFTFHEIGAIIATSNVFISFAVSFYLIWMHAIHYTKPYEQKHIIRILFMIPVYSIAALLSFNYYWHVVYFKVISDCYEAVAIASFFALLCHYIAPDLHEQKNYFRSVQPKDWIWPLNWFKACFAVAWRTPRSGLTWFNIIWTGVYQYCFIRVTMTIVAVVSQYFGRYCEASQSPQFAHVWVMVIEGSAVTIAMYCLVQFYVQLRDNLAPHKPFLKILAIKLVIFLSFWQTLLASILTSPSLNVIKPSTMIAYPDIKVGIPSLLLCTEMAMFSIFHLFAFPFQPYTIKNHGNINYSWGPNLENKLGPNQGGRLGLRAIMDAMNPWDLVKSFARVVPWLFVGRKTRESDISYKSTNHHTQDFPLESPLSSNKSNFFSLLSNDEDRMNLTSTQRTGNDEDDRLIDHTQSYSPYQFPGYVPAKQRYDPNGKEIQNKRRKSSYEINGLFPYLESYSNQIPHEPLISELRSKADQGGQLTNTPLHSHLVRSNTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVQ6</accession>
    <name>A0A0B1NVQ6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">High osmolarity sensitivity protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005457">
        <property type="protein sequence ID" value="KHJ30053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVQ6"/>
    <dbReference type="STRING" id="52586.A0A0B1NVQ6"/>
    <dbReference type="HOGENOM" id="CLU_149439_2_1_1"/>
    <dbReference type="OMA" id="GMFMAAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12818" checksum="652C8777AA6E5121" modified="2015-03-04" version="1">MNTRQNINFHGSSHPSSSTTSRLSIATSATSNAKSRQLAHLHSNLATLSANLANLENLLRMTSIQAESIKGLGAWHCGLFMAASKVLGEETITGSDTAAATHNNNTSKTTTTTSTNPTSPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW45</accession>
    <name>A0A0B1NW45_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003892">
        <property type="protein sequence ID" value="KHJ30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW45"/>
    <dbReference type="HOGENOM" id="CLU_2322092_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11407" checksum="EC18F9584E20AECF" modified="2015-03-04" version="1">MASRIFRDTESSFSKNIILIDQSSWLPWINIIKSRAVRGCRVNVWKYIDPSITSQPELPAIPRKPKPSDIKAGANGIIQLDDSEFAKIQYIEQEYKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW90</accession>
    <name>A0A0B1NW90_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003804">
        <property type="protein sequence ID" value="KHJ30652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW90"/>
    <dbReference type="STRING" id="52586.A0A0B1NW90"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="370" mass="40907" checksum="E16ACBE11574B297" modified="2015-03-04" version="1">MKSVASFEGTSQETTKLPKIPQISENTWATVARNGKKKARVITNSKAQMTPARKTTQTLPNTQKYSTTTLVDKRLFVRLPLDHEWRKLSPAGIREVVVQKLAISPTLFGKIKPVKSGFALSLCSTEAREAMLNAGNRLFLTGAKLEPSANWIPMIIPTVPSTIRKIQGEIEVSNSMLIDEVERVCSVRPAHVKLYGGNKAEAPHKTWMAYFSKAPRAGFRVFDESGIARLFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHTEDLCMASTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMRTFRQIGEREYQAVLRAKAAEESAVFAENNIMDLTSSQDSEVDGDTDNILASPVENSKDGALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX40</accession>
    <name>A0A0B1NX40_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003440">
        <property type="protein sequence ID" value="KHJ30937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX40"/>
    <dbReference type="HOGENOM" id="CLU_2039804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="121" mass="13424" checksum="AA4F78D276CDBDF5" modified="2015-03-04" version="1">MNAEITAIAEGIEATIRNSPIHFARNLIVFSDNKTAVNIFDGRIPLTSQAQALKILQLQKDWLSRRRLPHVAQGTVVGEWVPGHSNNLGNDEADRLAKHGSEIPSALVHGYTYATIKQSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX82</accession>
    <name>A0A0B1NX82_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003367">
        <property type="protein sequence ID" value="KHJ30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX82"/>
    <dbReference type="STRING" id="52586.A0A0B1NX82"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080367" evidence="2">
        <location>
            <begin position="29"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="422" mass="46552" checksum="B7801CE9C531D5B3" modified="2015-03-04" version="1">MRQRRGRAWHARLMICTTAISSIESSLANFKDDIEKEEVAAFQAYLQLAIDNFAAVDTSPTPPKIPSHSRPSKGSRHGLGNDKIAVNKVAIAIPRNITSLESSLRKTQGTSSLPKIPKKVESTWATVAHKGKKKAQITLSINASVVSSRKATKSLTSKDKSPTRDSSKIAVTDRRLFVRLPQEHEWRKLSPAGIREVFVNKLAISPALFGKIKPVNSGFALSPCSTEARETMLNAGNGLFLSGAKLEPATNWTPVIVPTVPANIRKEHGEVEVNKSMLIDEIERVCHTRPAHVKLYGGIKPGAPHRPWMAYFPTAPCISFRVFDESGIARKFKKQQPLEFCKRCNGHYPTKNCSRAPSCGNCGSTNHTEQLCMAATKCRNCGGPHRSDSRRCFGRPTRSGALTKEQLKTYRQAGEREYQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXC6</accession>
    <name>A0A0B1NXC6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003308">
        <property type="protein sequence ID" value="KHJ31047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXC6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXC6"/>
    <dbReference type="HOGENOM" id="CLU_031567_1_0_1"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="255"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="458" mass="52688" checksum="F17FE81533EDFA11" modified="2015-03-04" version="1">MEPLGPLVREFQRSYSDGSGYDLSLTLSPIAPSWNPDRLRQIYQSTNFQNVEQDIRKHLMVEKNLGVRIQKEEADAWVAVYQTYWKAIGEILKLEAAAGTNMKVLWTNVFDAWKEMTLTLVRGYDKNLFEAWTVPCLYVAGKYMRIFAIRADQVVARQNFSSNRLLISDVNVESKEHEKLEDAARILNKIFQVCLADRAPLEESRKWGIYYIINLLFKTYFKLNSITLSKNITRALQAYRGDMPTLDSFPMAHQVTFKYYFGVISFLEEAYEEAEKHLLEAWNLCHKDSTRNKELILTYLIPCRLLTTHTLPSLTLLQSYPRLQTLFLPLCRCIKRGELSGFDNALILGENNFTKRRIYLTLERGRDIALRNLLRKVFIAGGFENSKDPSQPPTRRTRIPVSEFGAAISLGSRESLENDEVECLIANMIYKNLMKGYISRERGIVVLSRTGAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXT5</accession>
    <name>A0A0B1NXT5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ppe family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003135">
        <property type="protein sequence ID" value="KHJ31197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXT5"/>
    <dbReference type="STRING" id="52586.A0A0B1NXT5"/>
    <dbReference type="HOGENOM" id="CLU_099565_0_0_1"/>
    <dbReference type="OMA" id="FLACTTR"/>
    <dbReference type="OrthoDB" id="2118427at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080370" evidence="2">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="24000" checksum="5778F7EB8882834B" modified="2015-03-04" version="1">MQLSYLISFLACTTRLSIAYPHGLENRAGNQPSNDAVTRAVDNFARDADTVSAALNNLPTLTDKNEISTTARRAFDAESDEDNQRSVLAAAAGGAGDRSNSLIMRFTPAVLDGLDAIARAGTIDAILQNLPAVERARNPNILPSITQLSNAALDALGINNKQAKNFPPTTGTSKLAQIGGNGGNGGNNNNNNNNDGGRDNNNNDGGRDNNNNNDGGRNNNNDNRNGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY81</accession>
    <name>A0A0B1NY81_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative r3h domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5832</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003015">
        <property type="protein sequence ID" value="KHJ31297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY81"/>
    <dbReference type="STRING" id="52586.A0A0B1NY81"/>
    <dbReference type="HOGENOM" id="CLU_022096_2_0_1"/>
    <dbReference type="OMA" id="GMQRDDS"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="321"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="616" mass="68363" checksum="A2B5CCB87DDE6C83" modified="2015-03-04" version="1">MAQYTDDAFGIQNFTSNRCPSSLRGSHMIYKQPLHQSVQQSPHLEAYRSGPSLQSPGLYTPEDFAAAAAVRYDPLPRYDRMGTISLPSNHPFDNQTWSYGALNSSSLIGLSSRTKTASRRPGLPNGWMDQQAPIGQNYQILHSNSQFVPPNFHQTQRRSSPTCASESEDLIPTALVIKNIPFSIKKEQMLSMMTDLKVPLPYAFNYHFDGGVFRGLAFANFSSPEETKIVIENMNGLELNGRKLRVEYKKMLPLQERERIERDKREKRGQLEEQHRPIPPGQAQNPLHTQTSMNSIGSSHAVSPSPISMRDKFGQDIDLNDPVSLGYYTDIVVFKKDPNRDSLIFPASISPADRRQIHTMAHHLGLEHRSQGEGEGRCVQILKKRPTELSSPITQLPGSYYNETRRGLNRAATIDFSEALGNENYQRTIGRQSSGLLDIPQSPRIGGLSGVHNLRAAKSFADLPASGTPNLTPTSVGGMTHRDEVYINNNLSNLSLYENRGSSARANPPSRICPERDTHSTNTGAIGSQRPSNGCKSEDTPRSGQTATLSHREPRNPGPDWGAGNGSFSRSRQNGQANRGSTEVDLIGFNNAWDDDRTQEPTERNGCIISRPARFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYA6</accession>
    <name>A0A0B1NYA6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002988">
        <property type="protein sequence ID" value="KHJ31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYA6"/>
    <dbReference type="HOGENOM" id="CLU_029060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059228" description="Secreted effector protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="70211" checksum="43B29B6CF6AB3BE5" modified="2015-03-04" version="1">MRFPVFFVTFLRLRKTFAVHPSEGLLSDRVESTALPDRNDNKGYECGNVFFTYSETRQALQLYHQYLNRNPAFVIQENTSPQVTPQKFQALDNYVPQQNFDFPGNSFPQESDVSLNFDIDKEIDNLKEFNDQNYYNIFDDFNVQEYDNAQYNYGLKKRNDFGKGYVPRQYHGRLYGDADTSKYILWPILRGNLTPFSSPINPFYIVIDRNGENIIDVIASMANGKHIKCIRRDSSLTNLSTPGPETNNGYVCTHEFLSDELIKNSLMLAKKNARKIRFYPIPYLGNLYPYESYYRLWPIFARRKLYKGDSSICNFYLASSKNETLILKLGRVEPFFLIINKKYELVDVVAEGVNNNYIRCSRSNEILTISIPDTPNLVKRSGFQCGKLFFDIEDIKRVGSEAKRSLFSYKSKSLPQEYDGPPFNEPVFLWPIMSTSKRYIRGSMGPYRVVITPDLKIKGAAYYFNKKIRKCEPRKITGQINHDSNDYFCLGFVITNQQLIRTTKIGCSKMTGKSVTFFPALYEGPKFEKAGPYFTYPVYGTNNFKTNAGLHRVVFNADCEVVGALTAMMVNVNANAERQLVKCIKLKDSETSSSSFDPENPISEHRFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYQ3</accession>
    <name>A0A0B1NYQ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative prefoldin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYQ3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYQ3"/>
    <dbReference type="HOGENOM" id="CLU_113004_1_0_1"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="116" mass="13619" checksum="8C86F6954B678746" modified="2015-03-04" version="1">MVQEITQKQNQELQSQYTVYKTNLEQIARKIGDVEQELEEHCLVLESLKNLPAHRKCFRMINGVLVERTLQDVIPALKTNSEGLKKVLNDLVKQFNNKQIEMNDWKKKNNIQVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYQ8</accession>
    <name>A0A0B1NYQ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003244">
        <property type="protein sequence ID" value="KHJ31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYQ8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYQ8"/>
    <dbReference type="HOGENOM" id="CLU_025069_0_0_1"/>
    <dbReference type="OMA" id="AYPQFEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005422544" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="150"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="479" mass="54127" checksum="BA50F9F134DEBB00" modified="2015-03-04" version="1">MMMRLFIFVLFTYVSLLLASPAVFSVYDDLLAYPQYEIYFSESLVSNSESAFLISQKSPASQVISGLTRLTSISSQQGVENEKSPPRYPTPSDKTYEILHLQGVPHLCSIPIIAKSQLNETFERESRSLERQELARATERAWELLQGLDGSCLYFISGWWSYSFCFNAEVTQFHHLTLQPGKQDSPKRDPNTKPFVLGKATSKEGSRDSSNSKLNGLTDLHRTTQMPRLELNSKGGTRYLVQRMESGTICDLTNKPRRIEIQFHCNPSMTDRIGYIKEVTTCSYLMVVYTPRLCSEVIFLPPKENKTYNITCRMVVEDNELLTQDELNNFEKVVDIDLQDISSKTTKDAETPKNIGGILVGAGRWINSEAQRISIPEIFSNEVQDYKDQAVEIIARAMSKAEGGQVEVASDADLKKLDLDPDMVEALRIEVQKMAKEKGWKIEIVDTPGQTREILGIVDGENEADTEKKDKEGQIKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZC5</accession>
    <name>A0A0B1NZC5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002623">
        <property type="protein sequence ID" value="KHJ31737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZC5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZC5"/>
    <dbReference type="HOGENOM" id="CLU_025145_3_1_1"/>
    <dbReference type="OMA" id="RPALMDK"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="502" mass="56015" checksum="C4DB5FE5899A1FC0" modified="2015-03-04" version="1">MVVDTIYYDALGVKTDATELEIKKAYRKLAIITHPDKNPGDETAHEKFQAIGEAYQVLSNAELRKQYDKYGKERALPSEGFTDPAEFFGTIFGGEAFVDLIGEISLMKDLTRTIDITMSEESEEDKEVFPGEDVAKVESLKEEQARLASAEAAREKSGTEEGTSPAPPPVDIVENKPQPNLSANEKSVPSPSASGTSTPRKSHGISSQLALKDKPEDESNGFQSEDERNQRKKEKKKGGLSKTKRDELAAYEKERTRVRQERVETLARKLIDRLSILTETNKDPEVTKAFQEKARLEVENLKMESFGLDILHAIGATYVQKGTALLKSQKFLGIGGFFSKLKDKGTLAKETWNTISSAIDAQITIEEMAKMEQKGGEEWTDEKKVEYERKVTGKILTAAWRGSKFEIQGVLRDVCDEVLNDKKVPMSKRIERAHALVLCGEIFQKAQRNPEEEGDYMAFEQLVAEAAAKKESKKKSKEKDTKNNQVNETQETAPSTLNVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZQ1</accession>
    <name>A0A0B1NZQ1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002555">
        <property type="protein sequence ID" value="KHJ31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZQ1"/>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="336" mass="39710" checksum="01FA3F1F877C876C" modified="2015-03-04" version="1">MARVYADVNQTMPRSYWDYDSVNISWGILENYEVVRKIGRGKYSEVFEGINIVNYQKCVIKVLKPVKKKKIKREIKILQNLSGGPNIVELLDVVRDQQSKTPSLIFENINNTDFRSLYPKFVDYDVRYYIYELLKALDFCHSKGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHKGTQYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRKEPFFHGNSNSDQLVKIAKVLGTEDLFDYLDKYEIELDSQYDDILGRFQKKSWHSFVNSENQKFVSNEALNFLDKLLRYDHQERLTAKEAMAHPFFQPVRENETQLPGTPNEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV6</accession>
    <name>A0A0B1NZV6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hmg box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002826">
        <property type="protein sequence ID" value="KHJ31518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV6"/>
    <dbReference type="HOGENOM" id="CLU_025284_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="499" mass="56654" checksum="1E124C75AAA491C6" modified="2015-03-04" version="1">MSDLRSIFAELGLCQYLDDFIDQGFDSWQTILDIQESDFDVLKVKLGHRRKLQRKIANSRGYSFDRALESQDSPLFDRSAEEPPKVKNDAKDPGATLGTKRKYRRHPKPDENAPERPPSAYVIFSNKMREELKGRNLSFTEIAKLVGEKWQNLSFTQKEQFEQQASTAKEKYNNELIEYKKTNMFKEYSRYLADFKARHSRQNSGETDNLKRLKLEEPPINRNGSVTSNTASQTEESSNSNSDTASSDSTPSSTTSPWSQLKVHEESPARDISKLSSTAAFGSTISPNVVKSPVTNSPTHLLKFQDVSLNSSPLSHFSSRSLPDKSSYFQQMKENEAGEIHLSPPQLLPHLQPSYQFHSQTHQLLLEKQDPVSKSPRNCSVLNRICPAPASLRILMEPSIDRTNQTPPIFTDHKIDDRFERQLPPLLPNSLSPKSQTQDTIKQDQASSKFFNHLICNSSVQIPPIRYLSDYNDRQTLKMISTSSCDNMKHVSTSVSFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV9</accession>
    <name>A0A0B1NZV9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative duf544 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003948">
        <property type="protein sequence ID" value="KHJ30575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV9"/>
    <dbReference type="HOGENOM" id="CLU_007080_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="293"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="832" mass="94156" checksum="78CD2FBF052CA71A" modified="2015-03-04" version="1">MAAQEPIQQVSVISLDVLPCSTSYPKESVSQVEKDPQAQSLQLDSEDSAALCVRSGSIPSNEESKPQHSSSFESGTISKSENFNVSAEHVDKEPSGRPIESDEQCECEIFSKEISQLQDPPISKKIFPLNEEHYQLDKFDLKRKTQSLSESVSAIRLNDAPENLILKSNSNDSHIVHNIPEIANATVSKPVLCSEVATFDWDSKKRDHNVLDSTQVLAENSKRLSLENGLHYDIERNTRNEDQCKSRSSPHRQSLLKEEDSSLSQRVTRDSAQSMQLASLSSNSDNRGQRKDMYDIKKIKWYDEKSREIAKISPILIQNVNGPCPLLALVNALTLSTPAGLNTPLVETLRSREQVSLGLLLDAVFDEITSGRHGNITNELPDVTDLYSFLVSLQTGMNVNPKFFPAESSYIEESKLKERLWNERKKAGLFEETREMRLYSTFRVSLIHGWLPQPNSPEYAALYRSAKTYEDAQNVILMLEALETKLSHEGLNLEEQILLEDISVIRAFLDSYATQLTPYGLESIRSSICPGNFAILFRNNHFSTLYRHPKTRQLLQLVTDVGYSKNNDVIWESLSDMTGEYAQFYSGDFRLVSDMPAVQMSNQQNYEPDLISQETSQSLTLGRRVDTQSKISQMQKTQQEDHDLAMAIQLQEEEDQRHKTRLDLRRPSTNLSQQQNARSNQTRRKMEIDTNEPINSSTSRIRAKNGPVIPPRRSLLNIRSQPSPQAANLNVMTDHPPPSYEVAATQEAYIPPNIGQMETNSSYYDPNRLPRANHNLLTSETSRRSERRQQIRSQTLNSGSEQRNERRKGPVQGVVDKVISGQGRVQKDCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T5</accession>
    <name>A0A0B1P0T5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004256">
        <property type="protein sequence ID" value="KHJ30434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0T5"/>
    <dbReference type="HOGENOM" id="CLU_030669_0_0_1"/>
    <dbReference type="OMA" id="HINGNIV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0183">Conidiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="438" mass="49113" checksum="794460D84695B9EF" modified="2015-03-04" version="1">MTLPRCLPKRFNPLMTEEVPPYEVLVARRRLGQTDLTVQTRHDGSSKLSTTSNLEILDYAHLRAPLPKGIVSGIFNPSPPSYFLMRRSHDGYISATGMFKATFPYAAIIEENLERKYLKSLSSTSSEETAGNVWIPPEQALKLAEEYQIRPWIEALLDNDPITMSTGKDLTLKNIKPPPPFHYTQNIKPTKSDLQGHTSRSISPTKILIPRKISGTRARGSKLESNVTKAPEFTELSPRRITVEIEANKSLSKASRKVSLDSKSPIKLSDTGFDNSVNTIINGEDATHEKLEFTSENFCNEKPSETLMAAIEIDVKPENGEGFKNNQALEENSKTIIPSTFSLKNEGEELIVQTKEKLEVQEKVKSSSPISRNSKRKFDETEETYKDCQEGHINGNIVKRQRTESNELRKERIKSRALLGITVTLAIGAAVQYAFNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0U8</accession>
    <name>A0A0B1P0U8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002220">
        <property type="protein sequence ID" value="KHJ32262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0U8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0U8"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="45154" checksum="12B970FDCC5B2EF1" modified="2015-03-04" version="1">MPSPNPKGQSHELHVSELDVIATTGSTYPLQKKFQTAEFLRSMPHLRVRIPFNTALLRLRSKVIAIITKSLSDMEFVQTHTPVITSSDCEGAGEVFQVDLATKQESKNEGQCFFRSPKYLTVSSQLHLEALAHALGNVWTLSPTFRAEKSDTSRHLSEFYMLEAEMNFVNSMHEVMSIIQIITAAVIRDLYDSQTGNVILSRGPLGEQELRQRWDGLMQERWKCITYTEAIKILQSSSHTFKYEPKWGSSLQAEHERYLTRALGTTNSNCISPIFVTHYPKAVKPFYMLPSEPTKVGLETVECFDVLVPDVGELAGGSMREHRLEPLLNSMFINGLIPNLAPSDQELRDLKWYVELRKWGSVPHGGFGLGFDRLLSYLSGVPNIREVVTFPRWVGRCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P155</accession>
    <name>A0A0B1P155_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002442">
        <property type="protein sequence ID" value="KHJ31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P155"/>
    <dbReference type="STRING" id="52586.A0A0B1P155"/>
    <dbReference type="HOGENOM" id="CLU_016218_0_1_1"/>
    <dbReference type="OMA" id="GDWESCK"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900036">
        <property type="term" value="P:positive regulation of cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="36252" checksum="0560FB0BAA2B7381" modified="2015-03-04" version="1">MAFEEVAAIEGGSILPSTDFDIVQTYHRLLNDDPEITMPVAAIEALIQLLTITHIKTVSETLDLIINQSAYLKSQVPNSISLSAGTDLFQRFLVSSLKPNFGGASFENVRQHLIGNGRLFANRAKAARERIAEIGAGFVRDGNVVLTHGGSRVVGSLLSKAAEVSKSEGNVRFKVIYLMNEECASESRAVVSSLRAKGIPVATIGEGAVGYALGKVSLVMVGAEGVVENGGIISRLGTYQIALLAKAAGKPFYVAAETHKFVRIYPLGQYDLGIEQNVIKYETQDENEVHNVTPSAKADIESANALVDFTPPALISAIISESGVLTPSVVGEELINVWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1I1</accession>
    <name>A0A0B1P1I1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002349">
        <property type="protein sequence ID" value="KHJ32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1I1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1I1"/>
    <dbReference type="HOGENOM" id="CLU_004131_0_0_1"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="217"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="6">
        <location>
            <begin position="834"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119738" checksum="B381ED3E18555868" modified="2015-03-04" version="1">MATIKAIEGQAVHQIQSGQVIVDLCSVVKELVENSLDAGATSIDIRFKNQGLDSIEVQDNGNGISPQNYETIALKHYTSKLSKYSDLLTLKSFGFRGEALSSLCALAKVSIVTCMAQDAPKGTKLEFDVSGKLKETCVVAAPKGTTVSVRSIFENLPVRRRGLVRNIKREWSKVTSVLSQYACIQVGIKFSVSQLGEKDKRTTIFSTKGSQSFKDNIINVFGAKMLTNIVPLDLELCAEAPNGHSKEQHMSEIGIGITKNIRIIGQISRPNVGDGRQVPDRQMFFVNSRPCSLPQVAKTFNEVFKLITGSSNPFIFANFELDTRLYDVNVSPDKRTILLHNQDRILESLRSSLAKSLELQQSMIPMSQFSVQKTSNFKQTLINIEGKVDNSNSKSSSTSKANMTQNYDSKESLNRYTESGDDELNINSYDSTVEPESPSLGSRISEKKNMIINSSVVKENVELVTRSKNQEICNITKELINNCDALQDDTKRDIIVTKTSGISNDTINLSAKPNYKRLNESLSFSEKSPERPFPKKLCKPHEFDTRFEEFLNHIPPNSDISSSFTRRCSGPSFQNNKLSQSATITIGDNTTTKSLGTLVFSENTQKVCSFLTEKGEKKRISPTKVPEDFSKFGSNFSRRFSAPNSENLLQTSLNQHIDLSDQDLEDIESQKLSQTSLAASENTGDSDDVFSGTSSTPGVSDFTNAEDLEQCAVANLGMDIIFNDEAKKKACEEAKIQRMIREVEISAKILPEDKVNRSESLLKGLRKRNATLNLVQTVKTNVFEIKQQLESLEQRLLSFQKMPVLRKNRDVDHMAAEEKLSLKISKGDFSKMRIIGQFNLGFILASRSSHNLHHSHEELHNFDDIFIIDQHASDEKYNFERLQATTIVQSQKLAVPKILDLTALEEEVIIENLKILQSNGFGVRVNQSDNAQVGNRCELISLPLSHETTFSLSDLEELLTLLTDHSPGGSDTIPRPSKVRKMFAMRACRSSIMIGKTLTQKQMKKVVLNLGELDKPWNCPHGRPTMRHLCGLEVWDDNVWKKDVNGAAGTNWLKYLEQSRMNVTSDEEVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1K5</accession>
    <name>A0A0B1P1K5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative meiotic recombination protein dmc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002016">
        <property type="protein sequence ID" value="KHJ32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1K5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1K5"/>
    <dbReference type="HOGENOM" id="CLU_041732_4_0_1"/>
    <dbReference type="OMA" id="TTHGIND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="5">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="15871" checksum="AAF45F1B997FF683" modified="2015-03-04" version="1">MQTELLESLAANFATNQYRLLIIDSIMALYRTDFVGRGELSERQQALGTFLRRSAQMAEEFNILVFMTNQVMSDPGAMSFAGVDGRKPAGGHVLAHASTTRLLLRKGRGEERVAKIMDSPDCPEREATYIITAGGISDPENFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1N0</accession>
    <name>A0A0B1P1N0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003700">
        <property type="protein sequence ID" value="KHJ30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1N0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="291" mass="32134" checksum="910FD044B6E1033D" modified="2015-03-04" version="1">MSKIRTRGSNIEKSPDAPTNKRLFLRLPHEHEWRKFSPAGIREVIVKKLSTSPTLIGKIKPVNSGLALSPYSTEARKKILNAGNGLFLTGAKLEAATNWVTVLIPTALAVIRKELGKVEVINIMLADEVGRVCSIWPAHSKLYGGNKAEAPHRTWIAFFPKAPRGSFKVFDESGVARPFKKQQPLGFCKRCNVHYSIEHCSRPPSCGNCGSTNHTKDLCMVATKGRNCGGPHRSDSRRSFARPTCSCTLIKEQLKPYRLAGEREFQALPRAKFAEESAAKADNINNNVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S4</accession>
    <name>A0A0B1P1S4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003563">
        <property type="protein sequence ID" value="KHJ30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S4"/>
    <dbReference type="HOGENOM" id="CLU_099932_0_0_1"/>
    <dbReference type="OMA" id="ILMAWAI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22332" checksum="F58D4A5E0B2950FB" modified="2015-03-04" version="1">MRGRRTFRYPTEDSDNSASQPEEFLDEEEQEILIKSLDDENARTNQIYMRVLLIISFLSILPYLRTLFYSTSTLFSILGITSLLSTAYLLASLPPGQTNIAIIDRFSQSSIQKPITKHYVPNLLPSEGPIKQILPYLNVGLCISSAILGTLVEKKVGGLEYGLCFIPIINYGAVLITACLMGSINPEQELNTLKYKYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1T6</accession>
    <name>A0A0B1P1T6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative suppressor protein srp40 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003542">
        <property type="protein sequence ID" value="KHJ30841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1T6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1T6"/>
    <dbReference type="HOGENOM" id="CLU_1435429_0_0_1"/>
    <dbReference type="OMA" id="ICFENED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="22057" checksum="937806EDB1C608E7" modified="2015-03-04" version="1">MATNPPQSNQVHPLASLYKKSDTQEPKSHFKFFPTEDEHDDSPNSQAQASPHYKPQSPLTPFAKRDFESRDIRSSAPTPDTIHNKKGYTLPYEFEESICFENEDENVEYNDKGNRPSGCEQVGRSSIWTNDDMGKKNTSNECNSENQSDFQKWFWANQGQINRGWKKRRKLVMKEQKQKNKSKKNFKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P262</accession>
    <name>A0A0B1P262_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002157">
        <property type="protein sequence ID" value="KHJ32343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P262"/>
    <dbReference type="STRING" id="52586.A0A0B1P262"/>
    <dbReference type="HOGENOM" id="CLU_001858_0_0_1"/>
    <dbReference type="OMA" id="PEDFHTP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="907"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1262" mass="143879" checksum="538F8E9F6337A8D6" modified="2015-03-04" version="1">MTRGTKILYDEGNFNESVIHTTLWAVAPFARIPEDAPTELKKLAIEVHDPRRIYTIHKATRRHHFELLLDRFIHQIRYGCNCKACITTTCFSCRKRLANGAPVRRYNTTSARVLAFHMISQDNPEEGLCPHPAAERPKEKLKPSRSEITSIRDELKSNQNCEDKLSGIKSGLGEEKAGNIKLRVSKNEVNKKKVSGIQSTLDEPTTTTDHRSIIQNMFETVAIKMAEWLTPSNFEKLTNMQDESEINPNASIVCNKENGVGGKSSSSISSDISQAQIEEKPNKMNFETLQVFESLENPKSSSVAEDSLNSLAQSSYLDSKIRVKNSSPQTFSQKLEKEKLKNFSDEKFVSYNQQIDRLQDIDSPSQISIMSPGILTSSFHCRGTVSGSSLIESKIITTSPKKKLPKDFKIDINQGDTYVTSEKKSLTPEKSRNIRLPPQSLRILTIETIELMCSILQSDGTRENHFLYPFSILEELHRHRGSMKERKVLQRNDLFKKGTAYPNSLKEQWKAFIEQCFFDVLQKPQSLLLTFSDENRKLFDSQTIWYLMLRMTRVAPALVFDSLWNVAAALFHPPQNLKVVNETVIDFSSHRSMSKRYISNRDAADIVHICLHALIAAAPLVEDSRQFIDISRIRSLGLTMSAKDSNSAEKVALCLSYEDVFTNDLAIRLARRIFMAIPIRRRFSKCLETREPFIEDKSEPDILYTMLSTIKILGTRSSLALDFPNAERDIHEVRVPIILLDWARAVMLQDWQGSAEVPIDGPFGGALATMTAIYENRKSLLLSDIHFETEYFAERLDSISMPIDWLSFNPNKKTVHLLDYPYLFSSATLITYFRAINFSKMSLAHETAKCESLRVNFTMQDPGLELGAETREKLQQRLRTATTKFMVMEIRRTHVLLDTFNSIWRREERELMRPLKLRLGEEGGEEGSDSGGVQQEYLRLAIAEALDPDYGTFTTDSRSRMTWFQPGSPEPLWKYELIGIIMSLAVYNGLTLPVTFPMALYSKLLGEEVTELHQIMDGWPDLVNGLTSLLEWDEKNGLVEDIFTRTYEFSIDQFGKQVSREMKEDALNLCTWPQFSLLSQSAALNPCDAPLVTGENREKYVKDYIRYLTDVSVRPQFRAFKDGFFTCISPRSVSFFDASTLQSLVEGVQVIDIDELRRITRYIAWEGDANHHTIQDFWRIVAKYDIDMRRKLLEFVTASDRVPVGGMSGLQFAIQRNGTNDSFLPTSYTCYGILLLPEYSSKDLLENRLAMALENSKGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P291</accession>
    <name>A0A0B1P291_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003301">
        <property type="protein sequence ID" value="KHJ31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P291"/>
    <dbReference type="STRING" id="52586.A0A0B1P291"/>
    <dbReference type="HOGENOM" id="CLU_090424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="27844" checksum="394801CF533CDD62" modified="2015-03-04" version="1">MNNSDQNFLSSLTPPLNASALLRAEGSDPVTVSKSGCLHLGLLSIANAMQQLETETRERMGLAQEFLEIIDAWVKGKTETKAEAIIVPLIQKIAPTVTAFASSRSYIQLDENKQKRRNYNTSWATVARKSAKLPQPPLSAIPIPKKPDGNRKETESNDRKKDKRHFLRLGLGHAWRKLSPIAIKKMITVKAGVAATAIIAIYSVQLVYAIECMSDALRDTILTVGKSLGDRDAIIDVASDSTSLLVPNVPLSVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2D7</accession>
    <name>A0A0B1P2D7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubx domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001795">
        <property type="protein sequence ID" value="KHJ32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2D7"/>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="OMA" id="NKDHTDK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="325"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="406" mass="44405" checksum="26F29923FA9758E9" modified="2015-03-04" version="1">MEEPNHEALIQQFNELTGAAPAEALQYLTANRWDLSSAAAEYFTSQDEKEMEETKTEDKNSNDDRPYTGPRTLDGRPAAESAAKFDLNSRASAPPKKKSGIATLDSLNQEQNLSDNFDDSDDEDFKGGKEPRDLFAGGEKSGLAVQDPTENYNYPKKLARDILKMAKANAARLGGEPSATPPSKFRGNGQTLGGDDTPSRTVPNPEQKSPELGLAKTKTLHLWNDGFSIEEGPLRRFDDPQNAADLQMIRQGRAPVHLMGVRHNQPIDVQLIKHDENYKAPPKKYVPFSGTANRLGSPVPGSSANSSTPTPTSIEASTPEVELDPSQPVITLRIQLANGTRLPVRFNPTHTVGHIYSFIERAIPGSDSRPWVLATTFPNKNHTEKTLTLGEVPEFKKGGTAIQKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M4</accession>
    <name>A0A0B1P2M4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003482">
        <property type="protein sequence ID" value="KHJ30899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M4"/>
    <dbReference type="SMR" id="A0A0B1P2M4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2M4"/>
    <dbReference type="HOGENOM" id="CLU_1349783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059312" description="Secreted effector protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23040" checksum="56E496478F9C4B45" modified="2015-03-04" version="1">MRGIISIAFVTFFIFASFGTAHTRSNLGPRSLGRPRSLSRTRSTTNTRSIGRSRAKIRSLSLLRSRARILKRKSAQDDTPDAYRCVLNKYSQGYILTSKDEACKFINSGKKTKGISRWPQFYKPPDPNQFAFKSNNFQLWPLTEDQEVFKGSLFKSDFNNFVVLDANCQLAGVVALFKTPGTGQNKGEVKEYKNCEIMEMKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M5</accession>
    <name>A0A0B1P2M5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001718">
        <property type="protein sequence ID" value="KHJ32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2M5"/>
    <dbReference type="HOGENOM" id="CLU_063935_1_1_1"/>
    <dbReference type="OMA" id="FQPTPFD"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="222" mass="23476" checksum="4C480078CDFB740A" modified="2015-03-04" version="1">MSIWDKLSGRRTSPTKSSNSESNNSPFANSIQNTSSFDPQSTQDVSSILTSPSFVDPSQLHPLAGLNQQTLDYLSLEDSALSDLPGSQSALPSRGWSDDLCYGTGVTYLTALTVGGAWGLQEGLRRSVGQAPKLRLNSALNAITRRGPFLGNSAGVIALVYNGFNSLIGNFRGKHDSFNSIVAGALSGMLFKSTRGVRPMMISGSIVATVAGTWAITRKALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S2</accession>
    <name>A0A0B1P2S2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001695">
        <property type="protein sequence ID" value="KHJ32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2S2"/>
    <dbReference type="HOGENOM" id="CLU_1670680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="18185" checksum="8115BBECA2A050D9" modified="2015-03-04" version="1">MEVLLRKEMTNIISETDDVSPEINSSALSSKQLCLDNGPLTQVKHINRAQVMWKALENILCATGFCSEFILCRHFYDTKLTKFNTMEEFLNRIKQHSDGLDVKDIKLPRQILFALNLNNLSLDYRPLVTSITQCLRSNKNAFTKESLFSNLLDESKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T0</accession>
    <name>A0A0B1P2T0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003396">
        <property type="protein sequence ID" value="KHJ30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T0"/>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="46495" checksum="F3F3416E45D75B35" modified="2015-03-04" version="1">MESHRNGSPNPTQFSYFSRAQLSLERVNEQIRKNKIHQNAHERMSPSRGNSATSGKPRLLLMGMRRSGKSSISSVVFRKMPPHETLFLESTARLQKNSMLSFMDFQVWDFPGQINYFDRSFDLDAIFGGIGALIWVVDAQDEYLDAVARLNNTVLNLHSQYPHINIEVFIHKVDGLSSDYKQDVQRDIVQRIQDELSDNGIEHPNINFHLTSIYDHSIFEAFSKVIQKLIPHLSTLEALLNNLCRSSGFEKCYLFDVLSKIYVATDSSPMDMLSYEICSDLIDVMVDLAEIYGWARPASYLEKLEGPPWNKPLQDQVACQEVEACCVLNDGKRPIVLREANQYLALVAVAREGSYCKLPTIIENINVTVDGLLEVFEITKQAGNTSLITSTEASSTGNGSGIENENENDNGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P325</accession>
    <name>A0A0B1P325_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative myb dna-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001620">
        <property type="protein sequence ID" value="KHJ33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P325"/>
    <dbReference type="STRING" id="52586.A0A0B1P325"/>
    <dbReference type="HOGENOM" id="CLU_039317_0_1_1"/>
    <dbReference type="OMA" id="WRIVAQK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="35613" checksum="D0669DBA4408A133" modified="2015-03-04" version="1">MSGYRPGHEQGHNPYIDYSSHTDGNTDERVYVTQVSNSRHGSSQGLNTIGNSPIGGHQHQHQPSAQHSQPHAVYSEHELAHSSPQYSSTSSMIFGHARRMQAPSVPPPLPLPPPPPPPPPPQQQQTPSGTKRQRPEDLELEMSNMPGQQIHQSNIQSIHRQMGQQSIVYGGQTVQAYHTHPLPNQSHRSKMPRLSEDDAMNISSAPSVVGMEGMPAPAPRPRGPKLKFTPEDDALLVDLKENKSLTWKQIADFFPGRSSGTLQVRYCTKLKAKTTQWTEETIQKLRTALHDYEQEKWRIIAQKVGTGFTSTACKEKAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3A6</accession>
    <name>A0A0B1P3A6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001589">
        <property type="protein sequence ID" value="KHJ33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3A6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3A6"/>
    <dbReference type="HOGENOM" id="CLU_037350_1_0_1"/>
    <dbReference type="OMA" id="VPHIAHD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="427" mass="47747" checksum="16B25DFC642337E2" modified="2015-03-04" version="1">MLKKNISFELLIPPDPATIGPRLGQLFCKGRKPVPTPNFFHIASRGVIPHIAPDVVLSSDIQLEGVHMALEDFVQNKVCTSDMIPYPNLSLHKFTAMSDNVITLLAPRRTPAVSAVHGNSDSGIPIYTCRGFQTVSNKDYISCSRALSPDIIISMADVSYGLKPGKKRLAKMVSRTQNWLSEILLENRENLAIFAPILPIDSQDQNGYLNFISDEVAEKISGLAFYDSNLLLDLPITTNNTKILRLTLDEPSSPIDILKRISLGIDIFTVPFISFSTDAGIALTFRFPRPLPVDENIHSEKLQAIPLGVDMWLSCHATSLTPLAPECHCYSCKYHHRAYIQHLLSAKEMLGWVLLQIHNHHILTTFFTSIRESISQGHFDTDYQIFANTYSKELPVKSGQGPRLRGYQYKSEGPNEPKENTKEFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3H5</accession>
    <name>A0A0B1P3H5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003111">
        <property type="protein sequence ID" value="KHJ31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3H5"/>
    <dbReference type="HOGENOM" id="CLU_055871_0_0_1"/>
    <dbReference type="OMA" id="YVGPLIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="107"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="367" mass="41930" checksum="5C53C92E68593265" modified="2015-03-04" version="1">MLRMIIPVTFNNVTNQVVTSDSLNFPTVRRFGHPFLLWKISPQSLVQESFSFSESYLTEIELRRLHRRFGHPSANRLRSILERSGHDNIDKSKLETLTKFCVYCQKHGSSPGRFRFSLKDDVNFNYTIVIDIMYIEGKEVLHIVDEATRFQAARWLDNVTSKHVWDTLRQCWIDTYVGPPDYILHDAGKTFISREFVQNAAAMSTSTKSVPVEAHWSIGLVERYHQVLRRAYEIICEELKTYTLSKEMRLQMAVKAVNDSAGPNGLVPTLLVFGTYPRMTHIDPPAPSITQRASAIRKAMEEIQQFRSRRLVADALNQRNGPSVASLHNLPLGSNVLVFREGQANRSGKWTGPFELIGIENETCTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W3</accession>
    <name>A0A0B1P3W3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001696">
        <property type="protein sequence ID" value="KHJ32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3W3"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="16850" checksum="B354C24DB5F30F03" modified="2015-03-04" version="1">MSLPKRIIKETERLNAEPVPGISASPHEDNLRYFDVSIHGPNQSPYEGGIFKLELFLPDDYPMTPPKIRFLTKIYHPNIDKLGRICLDVLKSNWSPALQIRTILLSIQALLGAPNPDDPLAPEVAKKWKENEQAAIATAREWTRTHAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P414</accession>
    <name>A0A0B1P414_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mfs maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002360">
        <property type="protein sequence ID" value="KHJ32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P414"/>
    <dbReference type="STRING" id="52586.A0A0B1P414"/>
    <dbReference type="HOGENOM" id="CLU_011673_1_0_1"/>
    <dbReference type="OMA" id="EWSWKSR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="540" mass="61444" checksum="758D23BB76068251" modified="2015-03-04" version="1">MRPQFSSRKILSSNLIYPVYFRKFLLHSLALNGLLRPTRPELGFLHVRMRRPAVRLISTETKEWLKYEVQTGLKYSIIITVTGFFLIIMASGIQEEYRARIYPSPDEWNWNTRIQFRAARAREDSDDPWMKNWVSIGNSYKNVIKKLEDQSGEGQGIYEQVDNIPVIPVKTITQIGYDISQKSEAWRRGYYEVLMGLARVAEQLDNHVKNKTKISNLAWPANSVYSPSNPRPRPVPVGMPPSPKVEDCVAAFEAPDVFYSQILTTFGLTEKQKVDAAISYGLWLDFKGMPALAQKIYEWAVDKANSDLNIVNPSTGIINNYIGTSSENILTATTALALHHATHSNVELALPMFVSILRARKSLPEPPTSLLSSLNQVEEDSEPFFSRVITLIRKYAKPPTYPQPPSDGTESPYRDAKGRCEEAGIMLYIGEILFATMDAKSSQENGIAWTREAVDAAEHELGQKQTKNDARQVCKQCLEVGLQNWSVMVEKLGREEEQKMKSLNQSWLKFGNQKPDLSRWEREKEVIQSRFIRASGFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P435</accession>
    <name>A0A0B1P435_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01001656">
        <property type="protein sequence ID" value="KHJ33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P435"/>
    <dbReference type="SMR" id="A0A0B1P435"/>
    <dbReference type="STRING" id="52586.A0A0B1P435"/>
    <dbReference type="HOGENOM" id="CLU_044409_0_0_1"/>
    <dbReference type="OMA" id="QNICHRH"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="18382" checksum="772C68D287443922" modified="2015-03-04" version="1">MWVGIWIMGIIFYLVMGITVWIEGISRIDHDTPFGEFSSLYSEFTLKTSLALAIFILASIIQNICHRHLFSLQKYSLPNHRLFQWVTCPHYTCECFIYLSLALISAPYDRLFNSTVFMGFIFVVSNLAVTADGTKKWYDSKFGRDKVIAKWRMVPLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P437</accession>
    <name>A0A0B1P437_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor bzip</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001427">
        <property type="protein sequence ID" value="KHJ33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P437"/>
    <dbReference type="STRING" id="52586.A0A0B1P437"/>
    <dbReference type="HOGENOM" id="CLU_028615_0_0_1"/>
    <dbReference type="OMA" id="PQSWHPY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="549" mass="60237" checksum="F32A24C84852BB85" modified="2015-03-04" version="1">MSQKHHAPRSASRSPSYDDDRRITLPPVQPRNVYQGRTDLIECQLSVSDHRIRDPQLHSASNRYFRPKVYGVERDLGVHSILNPDVPAKTQNSARLQNESSELMIINQNPNLKLNACSPRIFSGRQSLISSTSTTDSNSGSLLWMTRPMLTPKSPSRAIHISRATTSGTLDAEESSPFMGSSKQIHTSEPSSTASLESSLNASSSISGQQNPTQRLSKNYPKSNHGGIPGSLNLQSLSNAPLSKIPSPSTSTTSSYNPPTSQNSPVSLIHQGGKASPSNPYYISGSGLGSSKQMTGGMQGSLVNLEGPYCTPDSPQNSSIAGISRQTSASDPIQVLTITTNQGLYTIPVDVHHASRLANEKRARNAGASARFRQRRKEKEKEANLAIEKLQSQVKDLEKNMEKLKTERNFYRSERDRLRDIMLRTPETRYVAMQTPQSPPQIPRSFPDQLETFSGTQQTISGRHDINSEEDESKRRGNIRDSFTDASFVVPSMSQPDLKASTGYSMIDIAQNTQHLYSGVSSSSSQSKLNAILTNSESSDTLRKNFNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P489</accession>
    <name>A0A0B1P489_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001624">
        <property type="protein sequence ID" value="KHJ33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P489"/>
    <dbReference type="STRING" id="52586.A0A0B1P489"/>
    <dbReference type="HOGENOM" id="CLU_430191_0_0_1"/>
    <dbReference type="OMA" id="CSISMFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="270"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="616" mass="70473" checksum="EC751DBDD1461231" modified="2015-03-04" version="1">MSSANDKLLAFEDQSAQEWGSDSIVVPEGTITVSNTNETGDKNLITLIDISSPPDVVNAQSKSVLSKPQTTAHDSPGLERIRKTSPRTKSRLGKSSKYDKWGRPEPLITYRKAAYDNFLAIEQAEKKKYLDPPPVDKGIFPALGCYLWPDWNESPTTLLGPRLEDLNQIRLENQVWIDLDEENKCINIYSHSVINADTVLANSVKGIRDAVEHAKATRFTASPLHLVYPPTSVEMRKLIKASFVERDPPKAMKLILVGEKLSNLERLEWEATRDNMLVLNIQFLQKHLVKNLLKYAPVKHWMRLRIHFGNISMSRFTNQFGKNGTSWPAFLEMVAAPRFSAIVDRNLGDARLALLFKEKICQLPDSFCSVHGRIPLKDIKFKDTEIIHFNINNQKFRMEGEIDESFDNSSQVYQIGSNSLYRDNRRNVLVETRTIDVERGLDWKLELIADNKDKVLSLPPELRTLIKDSIPVNNRFRIDALGMQYPDIAPSPSHLVFISSVIVRSIIQYRMKSSGFIIEIAIYREWIGAITKGEPEIFCSISMFHPCWDDETQDLSNKTYGRAWKNDLSNFFIESDQHTTGLEYLLAQIRTVQDYIIQARRKLTEINIDSIDLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4C1</accession>
    <name>A0A0B1P4C1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002826">
        <property type="protein sequence ID" value="KHJ31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4C1"/>
    <dbReference type="HOGENOM" id="CLU_1332790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="206" mass="23242" checksum="10CE4CF67C5E2192" modified="2015-03-04" version="1">MMAERQRQTSTRKSVHKGGGINVGQWKTKIDERDRSQAIKELRSMEQKIKTAFNKANTALSRKGIESRKARREYLKTLGTSPSCPIIMKTFRESDKDETCRAVDEVASLLPPPDLQQTLNILKEDIELRWGYINMTGETQDIQVVTGTMYPNPVDSPVESECEGDDLNQDHLLDDGESVVSSIASSFRSCSSIDFAVDYIEFINDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E2</accession>
    <name>A0A0B1P4E2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative short chain dehydrogenase reductase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002251">
        <property type="protein sequence ID" value="KHJ32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4E2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4E2"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OMA" id="NYLANYH"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="43908" checksum="C1601D73F3441474" modified="2015-03-04" version="1">MAIHMIIDVLWKYIPMVSRSWSILWTTLAIIIVSIAKWLSIGTRNTSERRMNGKVMMITGGTSGIGAALAFRLAQRGAQIILLVHQPPNDVFLIEFIEDMRSKSGNQLIYAEQVDLSSLYGIRKFATKWIDSAPPRRLDMIILCAATMTPPGKPRKVTEEGIEETWMVNYVANFHLLSLLSPAIRAQPPDRDVRIIFITCSCYIRCPPLYDDSKLRKEKWNPSRAYNQSKLAMNIFALAFQKHLAAYKRPDGAPTNTHVIVVDPGYVRTPGMRRWLTRGSLWGLCIYILLWHQAWIFLKSAEDGIQSILYAVMDAKFGRSTLEKLIKECQEIGFKRNDINDEAIAKILWNNTENLIMKVEKKEAEKRAIAKKKRQSQNSKDEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P504</accession>
    <name>A0A0B1P504_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001498">
        <property type="protein sequence ID" value="KHJ33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P504"/>
    <dbReference type="STRING" id="52586.A0A0B1P504"/>
    <dbReference type="HOGENOM" id="CLU_005247_1_1_1"/>
    <dbReference type="OMA" id="YVPSEPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="803" mass="93067" checksum="EDCD9626321CCA1B" modified="2015-03-04" version="1">MQASCTLIDNLIFQIASQTLLAKGLGWKDVEDWAYILSAPCADEMTRRLNESCYQVQSFVLLYILNKDIHSVKSLEILFLGVWGLVLDKKQRGKDIHCQLKKKKEFEECERNSINSNLRTNYSTKSDIVNLEYPFRSQQETHYESVYMDLYTFNDLAKKLLAHSCQKWPASMVNVARMVTVFANTYVLKSNCDPQSLDPHTLRQLCFLINNLIVSLSNQSTAEPYLLIVYNWNSQKILLELAAKFKPAVILSQESYRAIIKVLASHKKTENQREYMMRRARSWPPWYVPQHGMDNTEPDGEERSQVVVGISRLKEAGYSGDWFEDALSVIGGQEFDGTPTIQTRRMLPRPQKLDSSSDLDEMQPSLWAARVIATRDIHEAWAAFMQYKKKGGQPNLDMYLAMFQKLSYDVIRTNRRRQNKVVPGDGLEVLNVPENNYSDYYKRHIEPPCIEDLYSEMLRSGLKPKNRCLSFLVRNSRTPDQAIRYLRASGLSMEALESLGAFGNTQKTGDIMKVPLNIFSDYLYLICRFVPRLVHVSPFSLKNDGQPERTVYCLKTKSQFGAKLDQPLHLAAYLLSIRRPTVLQPWYSFFRALSRENTIISMEYAEHPKNDILAWNVLRSSFHDFSSLGLHLNTRGFIMICHGFEKYMQAVLKIINQKNDEEIDKSDIYGALEFLKAEFRKLSETSCQLYQLPDMYQPIRGILLHAYMRCLALVKDYEEILRTLVWMAQNSHNLKDILDQESVYSKLKFRRAFVVVRICLQGTRFEARARDIISSVDIWQGWPSSDEIEEYRYNSPIDADLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A7</accession>
    <name>A0A0B1P5A7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002318">
        <property type="protein sequence ID" value="KHJ32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A7"/>
    <dbReference type="HOGENOM" id="CLU_465543_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="586" mass="63912" checksum="BF7F6AC273FAF463" modified="2015-03-04" version="1">MLSNRLDDSYVLLSRGADGNKGKPSALGSSSSSDSDSDSDSASIFIARVDNCSSWVATACVSCTAAIFSTTAFVLAAERVSTAARGWTRPALLTDFWTRLLESRTRSSFVSREFNQRASSMAITAMSVPVEAHWSIGLVERYHHTLRRCYKIITEELKDSVTSKDVRLQMVIKTVNDSAGLNGLIPTLLVFGIFPRMCNLDAPSPDITKRASATKSAVDEVIRVRAKREVNESIGQRNGPSTTLVNNLTMGSKVLVIREGIAGGSGRWTGLFELLSFERETWIVRLSNGPTNLRSTVVKPYYIDDSDAIIATRKRREQAWLARLVICTTVISYLDSSLVNSTNEIEKEEVAAFKAYLRQAIANFADADSPPSPPQVPIHPRPKKGSGKGIDKNLAKKTTVATPRIILSQAVNRETNKEADPLKIPQASDKIWAVVARKGHKKARIVNVGPNYRIVVPTVNNNQTQVVAGNKSAPKPFNKKNSSTPVSDTRSFVCLPQEHEWRKLSLAGIRGVLVKKLSISPALIGKIKPVHSGFAFSPCSTEARDKILNAGNGLFLSGAKLEAATNWVSVLIPTVPAFIRKKQGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5C9</accession>
    <name>A0A0B1P5C9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dna mismatch repair protein msh4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5C9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5C9"/>
    <dbReference type="HOGENOM" id="CLU_002472_7_3_1"/>
    <dbReference type="OMA" id="KMTMLYK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002054">
        <property type="entry name" value="DNA mismatch repair protein MSH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="813"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="868" mass="97496" checksum="0CCB8AFA8AA01F8A" modified="2015-03-04" version="1">MSTTISKTNRDQTSNSSQSAYFRNYIPNPYHKARSVVGQGETQRIICAISEGRGISPTVGFASINVTNGEAVLSQICDNQFYIRLLNKIEAIGPSEILIISNYGPPNPKSKMYSVIEENISCAKLVTIDRKYWSETAGLDYIQKLAFHHDVEAIKVAVAGNYFATCCLAAALKYIELSLSLTFALHSLRIKYQASEGSMMIDLSTVQSLELIQNLHNSKSKDCLFGLMNETLTPMGARLLKSNILQPSIQEEVLTQRYHALEELITKEEVFMQTRQALKSVHDIERLLTSLIVLPTKPDIRYSEQLINHILMLKSFMEVIPLIYNALGGARSELLSTIRDNFCPENIERTIYLIKEVINDDVSYQKTPLDLRNQRTYAVKSGVSGLLDVARQTFKEATEDVHQHILELNQRLEIDAETRYDNSRRYYIRVLEVDFEGRSPPEILINCFRTKGYIECQTLDLVKLNQRIEDSHQEVILMSDKTIQELIDNIRGEVPILFRICESIAMLDMVTAFGHIAIANDYIRPEITDCLAIKSGRHPVREKVHPEKYIPNDVYASPQNRFQIITGCNMSGKSTYIRSIALMTIMAQVGSFVPASYASFPLITQLFARVSIDDSNEANISTFASEMRETAFILRNINKNSLAIFDELGRGTSSRDGLSIAISISEALIETGAIIWFATHFRELAQILSERPGVVNLHLAVGMSNENTITMLYKIEEGCVKEWHYGLPLARVIGLPPLILDVAENVTMALDALAATAKKSSRSFAIVRRRKLLLGLKETLKQAEQGSMTGKALLSWLQKLQEEFVARMEGIQNNIDKGNPMEKQMEEETVPDTDTDTDIDTNTNRDLDKSSSKSSGTGTVTVTDVYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5D8</accession>
    <name>A0A0B1P5D8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002531">
        <property type="protein sequence ID" value="KHJ31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5D8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5D8"/>
    <dbReference type="HOGENOM" id="CLU_012441_3_0_1"/>
    <dbReference type="OMA" id="FGNMANF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="475"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="675" mass="76307" checksum="0D55A219443693F5" modified="2015-03-04" version="1">MKPLPVLKKRKISTSTQNLNNSSSPNFDVISSDDTTFLSQAAQWNLEQDYETRPRKNRKIGIENSRLPIKTAEGVILLNVSDADIRKIESDSESSKTSDTKLTEKLISAEPTKITRKQILEATEDLAKTALLLRDNDPEDNVDAFKRLAQLGQTTHYEVKRLALMTQLTIYKDLIPGYRIRAISKEDQSVKVSKEVKKLRTYEQGLVTGYQKYVLELSKLANLERKNILKRNSPSLASIAITCACTLLISVPHFNFRGELIRILVNVLSSRLIDPDFIKCRETIEKLFREDEDGGPSLDVVISLSKMMKARRFRVDESIINLFLHLRILNEFSYKGSFNHVDKDTKKLSYTKKSRDKKVFRTKKERKLLKELKSVEQELKVADAVISSEEKEKLQAETLKQVFSTYFRILKVKPSNLMGAVLEGLACYAHLINQDFFGDLLEALKDLIKSNLEIDTESISSENVGESQNKVREVLLCIITAFVLLEGQEAAKAKTTLNLDLSFFITHLYKILYALSVDTSIELNAISQYISQEKESLLSKSTSGKINYQTTAVLLLRSVSSILTPPLAAQAVPPTRIAAFVKQLLTSCTHLPEKSCIAMTTLIRKVTKLHGKKIASLWNTEERRGDGVFDPLNCEVEGSNAFATTIWEGELLKKHFSPAVRDEVKLIEKNINEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N1</accession>
    <name>A0A0B1P5N1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002237">
        <property type="protein sequence ID" value="KHJ32221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5N1"/>
    <dbReference type="HOGENOM" id="CLU_1541250_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="174" mass="20333" checksum="3E974C45825F67B7" modified="2015-03-04" version="1">MDLVPSTQARQLDIEKKRYKLDLRRVELVGKVNMLLSLYHLASTLVILHLEQTVHGSISRELKLRSVLASLNAQKLEYEAKEKRLKGEKIFYSDDVIYALKEYMRSLHKGRESLEERKSLAENKLSSYRECGTERRDAAKVMRSIADKYAELRKELDGVRRDIEKLKGRPLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P3</accession>
    <name>A0A0B1P5P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002420">
        <property type="protein sequence ID" value="KHJ31989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P3"/>
    <dbReference type="HOGENOM" id="CLU_797389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079780" evidence="1">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="349" mass="40022" checksum="E2392E2A26B13A19" modified="2015-03-04" version="1">MQLQLVLIVITIVFVSITSSTDFWNEQTVFTEPVYYDCGSWIFYEENILEMLSSLGGNIDQLGHPFIEPLYNLRPDYRKISIPQELCKGNHLPGLRQECHFSVIIDQMAQIVDIVSQMNNGFFIKCKRVDQLVPQPQPYNLNECNFECGQEIITQNVIHLSLTRALSNIGPSDLRGTQYHGNLYAPELNYWIYPITQKNQKKSAAIVPEYTYYIVLTPSGEIKDVIAKLMHKDFMKCASTTKDPPDNSLDRNLEFGYMCGTKFLGSKFVKRTALHAKKYRKSSIRWNDFPKPYDGPGSRSGLSIFPILTNGKFYIGSVGRVYKYFIVINSNFEIEFAVMKTPEGYKLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5V0</accession>
    <name>A0A0B1P5V0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001866">
        <property type="protein sequence ID" value="KHJ32705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5V0"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="NENIVHW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34514" checksum="E15D180DCADE8E0D" modified="2015-03-04" version="1">MTTSSYDSCLLFNNNNDTFGIVGLQTDDTLFVANKRFVELEKQNLLHAGFEAKPCEILTNQNPLTFNGSNITIDANSINISQTTQCEKLEEFAAQAINPTLHDFKALNERIKWQIKHKHRGLKFTKLDFDSVQIVVFADPSFANNFDYSSQIGYVIVLKDENNANVIHWSSVKCKRVTRSVLASELYAMTLGFDVGAVIKLTFQCILKREIPLVLCTDSHSLYECLVKLGSTSEKRLMIDIMCIRQSYERREIAQIIWIDGNSNPADAMTKSKPCPALRKLIETNKIDVTAYNWVERIPTKNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5V3</accession>
    <name>A0A0B1P5V3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g0167</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="JNVN01002376">
        <property type="protein sequence ID" value="KHJ32059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5V3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5V3"/>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="78"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="79"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ32059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="36668" checksum="BA453242F24C68C0" modified="2015-03-04" version="1">MSKFTLALIAAVSAATGAGLTAVIYSSHSERKTASQTQPNASRDRPSDLYSEPSTKSPVDPAGIYQYGFPGPVADLAQRKALISSYDRRLRNPHWVAEHITPSSLKSPEADRKLSVFMEDESIPEKFRGKLKDYARSGYDRGHQVPAADLKWSQNAMNETFYLSNMCPQVGEGFNREYWAHFEDFCRRLTQRYPSVRIVTGPLYLPKKDNTDGKWRVNYEVIGNPPNIAVPTHFYKVIFAENETASSPVALGAFVLPNTPIPNSKPITDFEVPLETVERASGLEFANLLPPERRRRLCAEHNCSLVIREFTKRQNQSGGTNNKSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P658</accession>
    <name>A0A0B1P658_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative collagen alpha-5 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002278">
        <property type="protein sequence ID" value="KHJ32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P658"/>
    <dbReference type="STRING" id="52586.A0A0B1P658"/>
    <dbReference type="HOGENOM" id="CLU_863801_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079787" evidence="1">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="322" mass="33742" checksum="460876A5FA992657" modified="2015-03-04" version="1">MKSLSFLLILGLIYDVQGWANETEPVVWVTITTDMYTTFCPSSTKLSYGPDIFTAPAPQTVTITECPCICSEIIGLPSLPTQKASLPTPNILPKPSLTPISLSQIWVTVTETVSELTTFCPSPTELVQNSKTYTVTEATTLTITDCPCTVSSMVPGTIQSYTTSIFTTYYTGSTTITLSGITYPVPSSGSITIPLVEVSTVIVKTDSKNSYPLPSSSTIPYAEASLSSLIDTAKPSSSFTNIFSGQIPSQPVAITQASLSTNSAVSEGSSKTSSSKVVVTTKASSSKLNEPTPQVTANIAAKFDAEMGAAAAAAIGFAAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B7</accession>
    <name>A0A0B1P6B7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short chain dehydrogenase reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002036">
        <property type="protein sequence ID" value="KHJ32496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6B7"/>
    <dbReference type="HOGENOM" id="CLU_040671_0_0_1"/>
    <dbReference type="OMA" id="HNEPRVW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="39660" checksum="7B579D7823F1C52D" modified="2015-03-04" version="1">MTTKNNNSGNKFLTRSSPRVWLLTSGLSPISIRLIRKLLDNGDYVAAGLRPIEIDSKDEEISNEYCELVLECQSERRKAQGWKDRFRGIRCEARAISQCGAAVAETVQAFGHIDILLCCTSEGVLGTVEELALNQATKSLAQDQFESTFYSNVNYIKAALPHFRKKNNGHIMILSSICGHLGSPGISMFCAATRALEGYCDSLAYEIAPFNVKLTIVQTNKEVILLTSRLKFAPHQAPYENGHQSVTRFRHILTNIINGHYAEENECTKSKEGVIIEKYPYLSDEARDKLVMETVFALYTIGGHVNPPIRHIVGHEAVASVKERLKNASEELEDYVKVGCSVDILKDENSLYAISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H6</accession>
    <name>A0A0B1P6H6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60s ribosomal protein l2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001190">
        <property type="protein sequence ID" value="KHJ33848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6H6"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="27528" checksum="ACBB104A85A41CB4" modified="2015-03-04" version="1">MGRVIRNQRKGRGSIFTAHTRLNKAPAQFRTLDYAEAHGYLRGVVKDIIHDPGRGAPLARVQFRDPYRFKLHTETFIANEGMYTGQFIYAGKNASLTIGNVLPLKSVPEGTVLTNVEEKVGDRGALGRTSGNYVTVIGHNPDEGKTRVKLPSGAKKVIKSNARGMVGIVAGGGRTDKPLLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6R8</accession>
    <name>A0A0B1P6R8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001133">
        <property type="protein sequence ID" value="KHJ33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6R8"/>
    <dbReference type="HOGENOM" id="CLU_069054_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="27852" checksum="36C05E92D0FF8979" modified="2015-03-04" version="1">MASLKVFQKRMSSLAIRISFTTSKPPFCNYVLRNFTIGKPSKSSSKRKIQTSTGWFQHEFNIEPPPKLVSGIPNMATTEIITRRNDSRPSTQVDQYDHSTGALRPEEQPSKYIKESEKQSLNTNNTSATPEAKPRLKLRARKAAIKLTPGAVNHLRKLLGQPTPKLIKIGVRNRGCSGLAYHLEYVNKAGLLDEEVEQDGVKVIIDSKALFSIIGSEMDWVEDKLQQKFVFKNPNIKEQCGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Y1</accession>
    <name>A0A0B1P6Y1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative elongation factor 1-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000867">
        <property type="protein sequence ID" value="KHJ34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Y1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Y1"/>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10308">
        <property type="entry name" value="GST_C_eEF1b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="6">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="143"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="25842" checksum="DFFA17AC5C7D0459" modified="2015-03-04" version="1">MGFADLATDAGLHILNSWLTTRSYIVGFSPSQADVATFKALKVAPDSARYPYAARWHRHISSYQNEFSTLPGDATKEYSTYGPETTEASLNPVKAPAAEENDEDDIDLFGSDEEEDPEAERIRNERLAEYQKKKEGKVKPAAKSVVTLDVKPWDDETNMKALEAAVRNIEKDGLVWGASKLQPVGFGIKKLQINLVIEDDKVGLTELQEEIEGFEEFVQSSDIVSHQFRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P710</accession>
    <name>A0A0B1P710_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001085">
        <property type="protein sequence ID" value="KHJ34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P710"/>
    <dbReference type="STRING" id="52586.A0A0B1P710"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="56960" checksum="AEFF88D4DED0102B" modified="2015-03-04" version="1">MEISTESQAPSTDTSKQPPPIHNHPIIIVSPPPLSNLTSSNTSLAGRQILKPVAPSKRPVPENSIQNSTNNFDAANAFLPKELAEIVANRQRRERAWHARLMLCTTRKKKLLLSKAYLLLAIANFAAIDTSPAPPQIPSYSRPTKFCGHGSGKYKTTAKEVTVTIPRTLKGAVTSEESTQQIHKSTNPQIHKLPKPSQLNERTWVTVARNGQKKAPLLLTKDSLFEYHKSTSGGNFLLRQNREIIVQKLSISPSLSGKIKPVHSGFALSSCSTEARQAILDAGNGLFLSGAKLEPATNWIPVIIPTVPSSIRKVQGQVEINHLMLTDEVKRVCSMRPAYVKLYGRNKSETPHRTWMAYFPNAPRTGFRVFDESGIARPFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHSEDLCMATTKCRNCGSPHRSDCRRCLARPTRSGAPTKEQMKAFRQAGEREFQAVLRAKTAEESATSTEDFSVGKISSQTTEVDANANIIPSSPVDISMGDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P748</accession>
    <name>A0A0B1P748_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002038">
        <property type="protein sequence ID" value="KHJ32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P748"/>
    <dbReference type="HOGENOM" id="CLU_619935_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="442" mass="50702" checksum="7B07290EA4B050BC" modified="2015-03-04" version="1">MDFARAFSNDYVGKKFSLRPKGVISDMKTENLNEEEAFLFCDSIKIEKVHPVRHGPFKVPVQENFQNSEGFLSKKNSSSIKSLRRILFRRSSKIKSRFLKRPLNQIDTESSFCQAIINSRKQKLKSSISAPISNSNDICYKFPSEVAPNFNFRINIEVTKKLGKKAERNNQKSNIRKKKNLVVLRNKLLGRTSSAIYYKKHDCNAKGSSLFCSYKISDAFAKNSVNHSQTGACFSFQKFSPLIEVLTQKDNEIIHHKLSSNKKISQNYHKSKGCRNSQKYLEYSYYGPQSFKPIPHYFNLKDPPKFSSIMPSSTSAIESVSSKMDSSPNDKDLNIILSDPLTQSALRISTRCSVIGKENDYKTNPDLTYGIKSSCETMRYLEKDFWHGQEIFGKSRRQNLSKEINIIVKSQELKMMKKHPSPSKVELDRLQQAIADMLKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A2</accession>
    <name>A0A0B1P7A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001025">
        <property type="protein sequence ID" value="KHJ34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7A2"/>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OMA" id="KMYIEEG"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="33523" checksum="A2E5F2064883855F" modified="2015-03-04" version="1">MATSTGSNKVDAAIQKVTADTPQKLSGFALYSRFALAGALCCSVTHGGLTPVDVVKTRIQLDPKTYNKGLIGGFRQVVAKEGAGALLTGFGPTFAGYFLQGAFKFGGYEFFKQKCIDNLGYETASSNRTAVYLGSSASAEFFASIALCPLEATRIRLVSDPTYASGLISGFGKILKNEGIGAFYAGFGPILFKQVPYTMSKFVVYEKVSDAIYQKVDKSTTSDRLQTVINLGSGLAAGFAAALVSQPADTMLSKINKTKGLPGEGTTKRLFKIAKELGLKGSYAGIGARLFMVGTLTAGQFAIYGDVKKALGATSGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7F5</accession>
    <name>A0A0B1P7F5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001782">
        <property type="protein sequence ID" value="KHJ32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7F5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7F5"/>
    <dbReference type="HOGENOM" id="CLU_074183_0_0_1"/>
    <dbReference type="OMA" id="ICMGGEE"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20697" checksum="C007D22F19E30253" modified="2015-03-04" version="1">MAQTMLLTKNLTEFLSKNTNATIHTLLLVSPAGKLLSSSSSLPASRLRTQATLAHSLWSLYFPSVNFITEALPAIEQDAADKHELSTITIQFTHGLMIIRALECGILLVAINTCDIVSRLSASFSTASTPPSSFRGSGNGFDSVISTGTPNSRESQTTDIMQFQKQAEEVAKWLDNQLGDFKLYDGENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7H6</accession>
    <name>A0A0B1P7H6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative atfpg-1 atfpg-2 atmmh-1 atmmh-2 fpg-1 fpg-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000991">
        <property type="protein sequence ID" value="KHJ34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7H6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7H6"/>
    <dbReference type="HOGENOM" id="CLU_2005590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="2">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="14350" checksum="266585BC95892BC6" modified="2015-03-04" version="1">MAILYRPHRHSLNFVEKTTYDSTSQKNLHSRERNQDREDIRDMPEIAEVALVVHQIRKRLVGKTIRAVVAKDDANIFGKVGTTAAEFQNAMKEKKIIDAGQQGKYFWYNPFIFGVPLLFGTHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7J4</accession>
    <name>A0A0B1P7J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001732">
        <property type="protein sequence ID" value="KHJ32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7J4"/>
    <dbReference type="HOGENOM" id="CLU_2706639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="7856" checksum="4A9E6F878B932AD3" modified="2015-03-04" version="1">MPIKQSYALKSLCDEAVNVVSNNIEVYICGTNETLLNSQGRRKKELTSNTTTKKAIVTQGFAHVAGNNNGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Q7</accession>
    <name>A0A0B1P7Q7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001877">
        <property type="protein sequence ID" value="KHJ32699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Q7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Q7"/>
    <dbReference type="HOGENOM" id="CLU_1714663_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="153" mass="17925" checksum="982EE2291E680978" modified="2015-03-04" version="1">MELILLEGTLTWMCRVNKSTPYLTFFSKEKEDSILEYDPADELEASSDHIPILTKFRIKLPTHKAGEPRSLWKKAEWEKVNQQLSTKLEELTRNTIPLSTTEAIDQRVAKITRTIHQTAEGLIPKVKPSRYAKPYWTIEFSRLVKEARKVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P854</accession>
    <name>A0A0B1P854_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001805">
        <property type="protein sequence ID" value="KHJ32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P854"/>
    <dbReference type="STRING" id="52586.A0A0B1P854"/>
    <dbReference type="HOGENOM" id="CLU_016218_3_0_1"/>
    <dbReference type="OMA" id="MRDYVIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="468" mass="51132" checksum="2CF0BE260404C1A7" modified="2015-03-04" version="1">MDSSKSSSSCTRLSAEFQPQANEEVAEKSKASDVIKGSGPTMAELKKKAKEEKLARRARAVKEKHGGVTDVQVSQSSFVHQSKSEGQVGPKSHHKRMISSEIKVAQARGSQKRISSIPEVPATEDKTVELFRHLYRSRVTTIAGVNKETHPAVLALGLQMSSYAVCGSCARLVAFLQAMKKVISSYTTPPMNSLTRHFSSSVLSTQIDYLSSCRPISISMGNTISWLKRIIAKIDPGTSDADAKKMLCDSIDVFIQTRVTLADQAISDNIVKLIRDGDVIMTFAKSNVVQKALFQAFQRGKVFSVVIVDSRPLHEGKSLAAALIKFGINTKYCLLNGLSHNIRDVTKVFLGAHAMMGNGRLFSRVGTAIVAMEANDADKPVIVLCETIKLTERVALDSIVHNEVTPADELVTPNGILQGWQNIRNLQVCNIMYDVTPAEYIQMIVTELGNVPPTSVPVLHRLVNEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H0</accession>
    <name>A0A0B1P8H0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative duf1715 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8H0"/>
    <dbReference type="HOGENOM" id="CLU_093235_1_0_1"/>
    <dbReference type="OMA" id="QFYNEGY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20812" checksum="46857DACEB275845" modified="2015-03-04" version="1">MSFGPFTEVLNLEQDFFQSGFEQGLIDGEAAGRSEGRTLGLEKGFEKFCEAGRLYGRSLIWANQQPYLPPKIDQETKKEDNVDENNGDIANQVRKSHVACTASISELDFALPPIPNYQKLSQRIKSLHDLMEPETLSFENTEEAMSDFDDRLKKARAKLRLIQKLIDEQRVDQDGKVKGAKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L3</accession>
    <name>A0A0B1P8L3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001676">
        <property type="protein sequence ID" value="KHJ33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L3"/>
    <dbReference type="HOGENOM" id="CLU_475034_0_0_1"/>
    <dbReference type="OMA" id="HQNHEND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="574" mass="64832" checksum="84EB3988B6F94191" modified="2015-03-04" version="1">MSTASFKIPLKHEFGRDSSQGGHNHDKAKDTHSRPPYPESDHSYSSYDQEKIGLPAYNNNSEPSIEEIRREFFPPGAEPYHTPHWSWYTLQFQTPNLTRMDSSIHQNHENDKRFQSLDDKLNDNQDRDSVSSFKSSEPKGRSPSRNDILLAAVGGAALAIGGKGLWDRRKPKKHPVKSNAAHTAAIGAIGALAGYEGAEIYSKYMKKERKLDKYHISHQSKTGDRYRTHNSKSRDDIKSRRSVRRQTSSSYESSDLSSSESSHEDEKYSFETRGNDSSGSTTRLQKLATTALIAGATEAFKVRKEHGRWSGDKGKRVLTAAIGASAIDAVAEGSGKRQVLETIIRGLASSHLINGSRNQDDNRSSSSRSRHRSRSRSLKKNLVGSISTLLAAEIGALATGRKSVEKSRSRPRMSRSRRRHKSPSLSSSSSSSMSRNTSKIRHQRSKSFTDTARKGLAAFKSHKQNEYEQNRNKFSHQRSYRSGSSTDFSRTHNRYHDSVDHNERRNRRPSNKVTRDENSKSKKRETSRVTMHRSHNKTKNNNKKTLDNSDSCYSSRSSIEDDRYVMGTRVKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8M6</accession>
    <name>A0A0B1P8M6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative nuclear distribution protein nude</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001667">
        <property type="protein sequence ID" value="KHJ33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8M6"/>
    <dbReference type="HOGENOM" id="CLU_058884_0_0_1"/>
    <dbReference type="OMA" id="TITTNIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="138"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="44981" checksum="1233A2A37DE78763" modified="2015-03-04" version="1">MPPGSVNTHVAIYEDKSSSLTLEDSLAYYKSQYEQVEHDLAEFQASSHQLEIELEKDVEAAEKRERILKEKVEGLRYEVDEWKAKYKQAKVEASVAQSALQKEITTLRDASRTLQLKLRDVEVENDDFERQARNTSSSMEDLESKYNMAIERAVLMEEEIKFSEQERENLRIENQRLRDELSNAKIEADVMQDKFRKLQSFLTATTITTNIHNDDSFSPDKSLSSSMISTPPDPKSTEFIKPGHETPPSTPISESSGPMKASANTPTRVPKSRSRLRLPSGDFSATPKATARYSSGFRNSLGSAVTSRNARTRSATPSVIRHTKSKAPATRGLPNSNSLTHIRSLTAQMQRLEQRVQSARSKLPTPVVTPPRSTPRKESLNSQIPSSITIRNKRRTDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Y1</accession>
    <name>A0A0B1P8Y1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2784</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001461">
        <property type="protein sequence ID" value="KHJ33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Y1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Y1"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110004">
        <property type="term" value="P:positive regulation of tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="142"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="466" mass="53685" checksum="2800DD8A1FA378DB" modified="2015-03-04" version="1">MLDIYDFLIEKGGDPKKIKESQRKRFAPEEAVDEVIALYEDHRKTQYAATQVNSKINDIQKQIGIKRKAKENADDLMKQKLEFEKEKKELLDSAAIKELHLKRKIKTIGNIVHESVPVHNDEEFNAVQRLWAPENVKVEKRDVLSHHEVLTRLDGYDPERGVKVVGHRGYFLKKWGVFLNQALINYGLEFLDSKGYIPLQTPQFMLKDYMAKTAQLEQFDEELYKVIDGVAQNDKYLIATSEQPISAFHADEWIIAKDLPIRYAGFSSCYRREAGSHGRDAWGIFRVHQFEKIEQFVLTSPEKSFEMFEDMMAISEEFYQSLGIPYRIVAIVSGALNNAAAKKYDLEAWFPYQGEYKELVSCSNCTDYQSRALEIRFGTKLQTEIRKKYVHALNSTLCATERALCCLLENFQNDEGFVVPEPLQKYLPGSIDFIPFSKELPKDSTSLKNKKASVVKPVVEPLKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A5</accession>
    <name>A0A0B1P9A5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A5"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="116"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="340"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="631"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="977" mass="110840" checksum="F1C0EF710881AC7F" modified="2015-03-04" version="1">MSISIIGRLVDLAIPCFHSQHQNIYISRLVVQKRAISSVNRYLPAAFHNLHRPKPLSFTLKHRNYDRLKNPYRLTAIRNCSYRRNAMCMLDNENNTVSSSGEIPDKREVLPTNVIPRHYDITLEPNFKDLTYDGFISIDLDVVEDSTSISLNTLELEIQDTKIFSGSDLISSSPAHNYDESIQTSKFSFEKPLPKGATAQLQIKFKGQLNDKMAGFYRSTYKNSDGSQGVLATTQMEATDARRAFPCFDEPALKAEFTITLIADKDLTCLSNMDVASQKDVKSSISGTIKKAVKFNKSPLMSTYLVAFIVGKLNYIETDKFRVPVRVYAPPNQDIEHGRFSLELAARTLDFYEKKFDSNFPLPKMDMVAIPDFAAGAMENWGLITYRVVDLIFDDKTSGAAVKERVAEVVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNTFYPEWKVWESYVTDNLQSALSLDSLRSSHPIEVPVKRADEVSQIFDAISYSKGSCVLRMISKHLGEDTFMKGIRLYLRKHAYGNTQTGDLWDALSEASGEDVKNIMDIWTKNVGYPIITVTENEKEKKINIRQNRFLQTNDVKPEEDKTLYPVFLGLRSKKGIDESLVLSKREQEFEVPDLDFFKINADHSGIYRTSYSSQRLEKLGKAAKDGLLTVEDRAGMIADAAAVAASGYSKTSGVLDLLKGFSEEKEFVVWSEILSRLSRIQSTWIFEDQQVRDGLEKFQRDLVSQKAHKAGWIFKESDGHIEQQMKSILFGSAGLSGDPDIIKAAQQMFAKFAQGDVSAIHPNIRGSVFGIVLKYGGKEEYESILKTYKNSKNSDERNTALRSLGRARDPELIKRTLSMPFSNEVKEQDIYLPISALRSHPAGIQALYTWMTENWEELVRRLPPGLSMLGSVVSMCTSAFNSQADLERIEEFFSSKSTKGFDQSLAQSLDNIRSKNSWLNRDRQDVMEWVIKYTENAKKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A7</accession>
    <name>A0A0B1P9A7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A7"/>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="OMA" id="HLGWIDK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="594" mass="65598" checksum="0CE85D8AA45E8448" modified="2015-03-04" version="1">MVKELGLIFVAVYRSLLHLSWVDKLVDNIKIIFVQLYGEQLQKPHVIVITSNFDEYFDQQLQNLEVLEENSTIHQTRFENTKSYSEKYDFSESNSYLNEPAQIPSLFDGEYKSHEPKKAKSYDSSPTITPISSRSSTPAGHIVTGKSVPSGKSSRRTRKSAKSSAINITDDSKSVKNRAVTKKGRKWDELDLFDSSNDKHLDYSALPNEDSIEINNLGEQAGTLKDVENDHWGSKTSSGKFVLKDLDEQVSSILASARTSQNHKESSNGIMASSLDAIGGLLRNFIGGKILTKEDLEKTIKGMEYHLLKKNVARETVVRLCEGVERELIGVKTGNFESIQSKIRAAMESSLTKILTPTSCLDLLREIEAVTSPSGFPLPNSRPYIISIVGVNGVGKSTSLSKICYFLLKNKLKVLVVACDTFRSGAVEQLAVHVRNLKELSDREGGFVELYQKGYGKDAANVARDAVKFATQNTFDVVLIDTAGRRHNDKRLMSSLEKFAKFANPDKILMVGEALVGTDSVAQARNFNSSFGKGRTLDGFIISKCDTVGDMVGTLVSMVHATNVPVLFVGVGQHYSDLRNLSVRWAVESLLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9G4</accession>
    <name>A0A0B1P9G4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cia30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000438">
        <property type="protein sequence ID" value="KHJ35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9G4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9G4"/>
    <dbReference type="HOGENOM" id="CLU_059028_3_1_1"/>
    <dbReference type="OMA" id="IMVRSFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="25258" checksum="A6B5E0906B87D285" modified="2015-03-04" version="1">MLTSIFGGELPWSSRDWTSSNDTVRGGKSSSSFKFIESNSVAIFSGYLDVSTLGGAGFASQRTKGNDRVWDLSNYDGIVLNIKKADGKKYTFSLKDQVVAPTQSSISWDFNFITTGDEQVKIFWSDLEPTYRGRVLEDTTPLNLKEIRGFSLMMRSFFGFQEGRFALSLSSISAFTTKYEPYQDNFSDDAISYLEKISEKDNHDFTPPSQTWLNKYFGGCIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA19</accession>
    <name>A0A0B1PA19_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="JNVN01000528">
        <property type="protein sequence ID" value="KHJ35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA19"/>
    <dbReference type="STRING" id="52586.A0A0B1PA19"/>
    <dbReference type="HOGENOM" id="CLU_033446_1_1_1"/>
    <dbReference type="OMA" id="MSYQQER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052829">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042538">
        <property type="term" value="P:hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="362" mass="39192" checksum="88B780236DAA2D37" modified="2015-03-04" version="1">MNSPSINTSSSYEKESLIAQLAVQYATILTKKVFEETEKGTVTKDDESPVTIGDFGAQALISHAIKFNFPEDEIMAEEEANALKSNSKLANLVWEKVKNSNLADPDAQATLGGQIKSVNDMLEAIAIGNSNGHRKGRVWVLDPIDGTKGFLRGGQYAVCLALIVDGQVKVGVLGCPNLKFINTESTINDSTPSQTSNREKGILLSAIEGQGAICRVLGEGGLTRSSSIRMRTLKDFSKAIFCESVEANHSSHIDQGKIAVELGINEPSIRMDSQAKYASLALGMADIYMRLCVNTSYQEKIWDHAAGDIIVREAGGEVSDYLGNRLDFGQGRTLAKSKGIIASSRDIHQKVIDIVQKVLNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA47</accession>
    <name>A0A0B1PA47_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA47"/>
    <dbReference type="STRING" id="52586.A0A0B1PA47"/>
    <dbReference type="HOGENOM" id="CLU_048013_0_0_1"/>
    <dbReference type="OMA" id="HRRLEYP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="326" mass="36555" checksum="3BBF38F777AD53D8" modified="2015-03-04" version="1">MPPQTYLELVNKYVVSPGSSEKPLSSALSGYYVLEWGNTAIGYTPKAVVDALTALPKSIQDLIHVKVFYNELKLSLFENIPTFEARTAAAAILCDHWRKNRTFKVLDGWRSELYPVYGPGNELLWNIERSASALFGIVTYGVHLTAYTRDDNSNCGLKFWIPRRSATKQTYSGMLDNSVAGGIATGEEPLACLVREAAEEAGLEENLVRNNAKAGGTITYTYLRDERAGGEVGLVQPECQFIYDLELPEGVIPKPTDGEVEKFFIWPLEEVQAALINGEFKPNCALVLLDFFIRWKILTEENEPNYKEIKRLLHCELDLCGPHKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA58</accession>
    <name>A0A0B1PA58_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000988">
        <property type="protein sequence ID" value="KHJ34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA58"/>
    <dbReference type="STRING" id="52586.A0A0B1PA58"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="458" mass="50565" checksum="D725EE5AC25333AE" modified="2015-03-04" version="1">MQNLNFHNDSMDTSQESQALSTESSNQPPPLRQSLHYTIPPPLSHGRQILKPVAPSKRPIIERPTPSCSNKINIENAFLPKELAEIVAIRQRRERAWHARFMICKTAISSIESSLANFKDEIEVEDVAAFKAYLKLAIANFAAVDTAPTPPKIPSHSRPSKGSRHGLGVDKIAANKVATAIPRSYTGINSSSKKTQGTHSLPNIPEKLESTWATVARKGKKKARITLSTNAPLAPVRKETQSSTSKNKSPTRDSPKIAVTDRRLFVRLPHEHEWRKLSPAGIREVIVKKLAISPALFGKIKPVHSGFALSPCSTEARETMLNAGNRLFLSGAKLEPATNWTSVIVPTVPATIRKEQGEVEVEVNKCMLTEEIERVCQIRPAHVKLYGGIKPGAPHRTWMAYFPTAPRRHRVETAGQLTTQRSYVWLQLSAEIAVVPIGPTVVDVLHAQLVQVHLPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAL7</accession>
    <name>A0A0B1PAL7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01000286">
        <property type="protein sequence ID" value="KHJ35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAL7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAL7"/>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OMA" id="LNEPALY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070879">
        <property type="term" value="P:fungal-type cell wall beta-glucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904541">
        <property type="term" value="P:fungal-type cell wall disassembly involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079873" description="glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="95"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="419" mass="46897" checksum="E4ABF5E9952A18E4" modified="2015-03-04" version="1">MLLLTPLVTLLLAASVTASPRKINARRVNFDWGTEKVRGLNAGGWLVLEPWITPSIFQKLDQSLGIVDEFTLGEKLGNDDAYQILKSHWDTWMTLNDFQKIARSGFNTVRIPIGYWAYETVPGEPYVQGAAPYLDMAINWARETGLKVWIDLHGAPGSQNGFDNSGHKVAEPMWQTGNNVNITLSVLQMISDKYARPEFQDVVVAIQLLNEPLTPKLDFEKVKQFYREGYNQVRSVSDTPVILHDGFAPPSKWNGFLSVSDNDSQNVVIDHHEYQVFTNDLVALPASKHSELVCTNVASYSQGTDKWVVVGEWTGAMTDCAIALNGYLTGARYDGTFPGSKFVGSCQDKNQISNWDQTFRDDMRRYIEAQLSAFETHTQGWVFWNFKTEGAHEWDAFALLDAGIFPQPVGDLSPNSICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAN6</accession>
    <name>A0A0B1PAN6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative mrs7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000448">
        <property type="protein sequence ID" value="KHJ35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAN6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAN6"/>
    <dbReference type="HOGENOM" id="CLU_008958_5_2_1"/>
    <dbReference type="OMA" id="LQHYWDG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="252"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="546" mass="61435" checksum="48C2F74D94DAAE0E" modified="2015-03-04" version="1">MSSLRLLRSAARSPLYSVNSNFRLRSSATYKASQLTNGWKPISHPSALLLLISFKSVSTSTSTAPKLPSEPPPGFNVENAQKSVISNKLNENNNSLNGSKLVKGHDVGEDISNEESVKSNLARTDSPVPSEMNSNDKEDAAKDTKIQERKLTLSQKIKKEAQHYWDGTKLLAAEIKISTKLALKMAAGYELSRRENKQLQRTVKDIARLVPFSVFVLVPFAELLLPVALKLFPNMLPSTYEGQKSKESKATTLRVTRKEVSNFLRDTLKETGLPLSPATARKGEFTQFFRKIRATGESPSPEEVIKVCTLFKDDLTLDNLSRPQLVGMCRYMNLNTFGTDMMLRYQIRHRMRQIKRDDHAINFEGVESLSVPELQVACMSRGLRTHGVSPARLRDDLQSWLDLRLKHGVPSTLLVLSNAFMYAQGKSDSEFSSQIDALTGVLSSIPEELFHEMELEVHNAEGAATNKQRLEVLKEQQELIEEENEQNEDNKESGQATPRDNENIDEKEEKRTDVNMINMENNLSFEKDEPKVRVTPADMKEPGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAP7</accession>
    <name>A0A0B1PAP7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative cuticle-degrading serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0184</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000448">
        <property type="protein sequence ID" value="KHJ35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAP7"/>
    <dbReference type="SMR" id="A0A0B1PAP7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAP7"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="DLYAPGH"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062003" evidence="8">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="158"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="406" mass="42285" checksum="E40A046F48AF6270" modified="2015-03-04" version="1">MVSFTNLAILAALVFPIIAVPPPVSEHHGKIRNYATTNFIENSWIVVYRRDASDSQISNHEQSVKSFFGKRDKTKKKKTAHGIKASWHMRSLRGYHIHTNEDFITTIAASPEVDYIERDTLVSAYDLDTQSNAPYGLGSISHRSSQSSTSYVYDTSAGRDVTVYIVDTGVYAEHSEFNGRASMGANFVSGSANTDENGHGTHCAGTIGGSTYGVAKNVTIVGVKVLNADGAGSNSGVISGINWVASNAGGSGVLSMSLGGYYSAALNQAVTSTVNSGVSVVVAAGNDNANAALYSPASAQSAITVGAISSSNAKASFSNYGSVVDVFAPGVNILSSWIGNKTATNTISGTSMATPHVAGLVAYLISLEKLSSPSEVSSRVSSLAVSGQINGLPYNTPNRRAYNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAR8</accession>
    <name>A0A0B1PAR8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome p450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001071">
        <property type="protein sequence ID" value="KHJ34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAR8"/>
    <dbReference type="STRING" id="52586.A0A0B1PAR8"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="OMA" id="NFGHGPH"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="526" mass="59501" checksum="9E03061A4D4BCBF5" modified="2015-03-04" version="1">MRLDEMSWIVGNQQKYISGNTATLFGVASILTTIYLIYKYVYGTKGFPIMGKPSDPDFRLAMIEGVSKYPNSPFFLPTKPPVLIAPKSAVSLLKSIKDDEASFTAAIRDQFHPKVTGVGDNDPLLVTVVKSDISRQVASSLKFLQDEAAYSFNDKLGPCEDWTSIVLYPKLAEIVALISSRIFVGRPLSRNKDWVDVTVNYTFEVMKAKNAIPKWPEWIISILGPHIKEVKSLHKFRERATVLMKPILDAQLAKTGNEKLFSIDGDEEGNGIAWILAHMEPEQRRDPKVLANQLLALSFAAIHTTTNTTSQAILDLAAYRQYIPILMEEIDKVILEDGYETSEDGVLRLRKSSMPKLSKLDSFLKESQRVNPLSLVSHLRRTITDVNLPSGHTIPKGIKIAIPAWYIHNNSDSLFSPGITKPLDEFDGLRFYNLRKLPGNENRHQFVSTSYDSLSFGHGNHACPGRFFAGNEIKVIMIELMRNWDFRLPGDNKLEGGAWRRPRNKHHQIECRPDPNVRIEFRKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW2</accession>
    <name>A0A0B1PAW2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000843">
        <property type="protein sequence ID" value="KHJ34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAW2"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="OMA" id="WGADIEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="56498" checksum="A2CF260B24CFA015" modified="2015-03-04" version="1">MAEHFFPSPIHAELEDIKGAIYPEISEPISNYIDEVEFEEAISKLPNDRAPGPDGIPNRLLKQCRKTLSIILKDLLLRYDTANAYKPIALLNTIGKLLEKLVANRISKAAEKYGLLLEEKMGVRAKSLDIFGAFDNVSHQRLVHNLREKGTPSWMITFIESFLKERSTVIVLGSFKGDQIQTSTGIPQGSSLSPILFLFFASTQLSTPQTATSSAVGFVDDTNILTWSDTTEENCLRLQQLHEKYESLDKTHGVKFAPNKYQLMHFSRARNKHNLQAPIIIQSHLTNPQISLRILGIHLDPKLNWGADIENVQWKTDLQMRALNRLAQSTWGATFHKTKLLYNTLVRPSLMYGSPIWAEAGLNGKIPERIVTGAYKSTSSRALEHETSTLPIEIYLKQRRVQFAGLLKRQPVQQTITAACEKITQRGIRRDNRRAKMKIEDIAEWEGFCDGIESQKAKNRLVKLRQIGNGQIPGQIKNECSALVTEHLQTLKYGKQLTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW3</accession>
    <name>A0A0B1PAW3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001045">
        <property type="protein sequence ID" value="KHJ34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW3"/>
    <dbReference type="HOGENOM" id="CLU_076635_2_0_1"/>
    <dbReference type="OMA" id="DMDREWK"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="110" mass="12717" checksum="23458CB745CEE994" modified="2015-03-04" version="1">MSDEELDLAWKPNKRPQSTIAQNFSIDLHDLFKISNSISDLHATVYAKKRAVYTQTSELREIERRLREIEERLTSAGIQPVSLNHNHNMRRQQSSQNDSFNTTSSISTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB61</accession>
    <name>A0A0B1PB61_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gpi anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000203">
        <property type="protein sequence ID" value="KHJ35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB61"/>
    <dbReference type="HOGENOM" id="CLU_2120694_0_0_1"/>
    <dbReference type="OMA" id="ACDCTHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062016" description="Gpi anchored serine-rich protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10025" checksum="2625978141CA7B86" modified="2015-03-04" version="1">MQFNVFALFAFIVSVVMATETVTVTVCAPSATYVPSQGYAAPTAPAYAPIASGSPAVNMPGAPSGGYAPPAQSPVPFTGSASSHGVSSLSALIVAGFVALAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB70</accession>
    <name>A0A0B1PB70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative spo12-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000200">
        <property type="protein sequence ID" value="KHJ35937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB70"/>
    <dbReference type="STRING" id="52586.A0A0B1PB70"/>
    <dbReference type="HOGENOM" id="CLU_132226_2_0_1"/>
    <dbReference type="OMA" id="YTSMEYH"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="123" mass="13750" checksum="8EA68E482DA99B9E" modified="2015-03-04" version="1">MSGNVLKNRDINTKNSSSPCQMDSDRKPEYTSMEYHRKMFQSKNDENQLLPKREKATYVSPSDTIMSPCTAKLSAYRNKQVGKAKPKSLFAKKSSKSLGSTEDFFASSTSKDNITIAIDNPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB95</accession>
    <name>A0A0B1PB95_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phospholipase carboxylesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000180">
        <property type="protein sequence ID" value="KHJ35967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB95"/>
    <dbReference type="STRING" id="52586.A0A0B1PB95"/>
    <dbReference type="HOGENOM" id="CLU_062889_1_0_1"/>
    <dbReference type="OMA" id="NWMWGED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="234" mass="25909" checksum="39DF29F2DD0EE814" modified="2015-03-04" version="1">MALPATIGISLRAPHPIPPFLTGSDTPGFRWSDDLLFDELRNCLDGDAGFSCAIKLLEEIVMVLLHQCGFKERDIWFLGLGQGAMAALGLITKMERDGKASPDGFGGVVAIGAGLPKESLTWIPAEVSEKLKTPVLLCGGSNQTQVTRNTISCLKDRFGNFLYVKWEKQGDGMPRNREEMLPIMKFFAQRMRSWAGSSCTARAYLPRFELPAIADKLEIFTFTRCRCRRLVCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB7</accession>
    <name>A0A0B1PBB7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative deubiquitination-protection protein dph1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000171">
        <property type="protein sequence ID" value="KHJ35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB7"/>
    <dbReference type="HOGENOM" id="CLU_024293_0_0_1"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="418" mass="43914" checksum="271F321EA4B7D4E6" modified="2015-03-04" version="1">MSEDISTEGDVLITFKVKTSGEKSHTITAAETMTVLDLKTKLSGDDYEKVSVDRMRLIYSGRVMKDTEMLSTYKIKNGNTVHMVKSAASNTIQRPANSGSSTSSSAPAGVPLNMAAGTANNPLAGLTGARYAGHVQLPSADIFGADGGMGAPPSEDQVASLLEDPNFLQTMNEALNNPALVDMLLNSIPGLRDNPEARAMFQSPEFRRMMTNPDTIRQAAAMRRLVGGGVGGSNAFPAPGLTDNTPESATNSQTPNNQFAQHNALAALFGGQITPGQTAHIPSVPNADGQTIPSNVVDTNLQNPFLSLFTNAQNPLQIPQITPAMAQQALAMMQAGGLNDILGRIPGSGSVAGLGTGLASEVATNPPPPPDTRPPEEIYSEQLRQLNDMGFFDFDRNIAALRRSGGSVQGAIEQLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBV8</accession>
    <name>A0A0B1PBV8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5603</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="JNVN01001017">
        <property type="protein sequence ID" value="KHJ34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBV8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBV8"/>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="OMA" id="AWILHYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045009">
        <property type="term" value="C:chitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="907"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="939" mass="106922" checksum="7316A8F096E3F3FB" modified="2015-03-04" version="1">MSYNSTNPNQGWTNDQYNLSNYPQGARPPAQASESYPDNQIYNTPNSRLPGPRNPSGTSLIDTGRSTPSDRLRAQPTYSVENMQNSYGHNKEYEQHYPVIPNQNYPQDYAFNPQQHQDQYYHNAYQPTPQEELPYSEYGSQQEQYLSETNDRSPMLSNNGALYGQNYSDFKDIKGPLTPSPAPTLRRYKTVKEVQLFDGNLVLDCPVPPRLLNQVPHAQPPERDEFTHMRYTAATCDPSEFFEERFTLRQRLFAKPRHTELFIVVTMYNEDDILFARTMNGVFKNIKYMCSRKDSKTWGKDAWKKIVVCVVSDGRAKINPRTRAVLAGMGVYQDGIAKQQVNGKDVTAHIYEYTTQVGISIKKDLVELRPKQQPVQMLFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLIDAGTKPGKDSIYHLWKAFDLEPMCAGACGEIKAMLGPGGKNLLNPLVATQNFEYKISNILDKPLESAFGFISVLPGAFSAYRYIALQNDKAGDGPLEKYFAGEKMHGANAGIFTANMYLAEDRILCFELVSKRNCHWILQYVKSATGETDVPDQMAELILQRRRWLNGSFFAAVYAIAHFYQLFRSGHSFLRKIAFLVEFIYTTINMIFAWFAIGNFYLVFHILTTSLGTPDLLGEIGVILGVVFEWLYLFTLLTCFVLALGNRPQGSNFAYMSMVIFWAVLMCYLMFASVFITFVSIKKELADGHISIADILKNQIFYTLIVSLASTYALWFVVSFLFFDPWHMFTSFIQYLILVPTYINVLNVYAFCNTHDITWGTKGDDKAEQLPSANLKPGGKVDVNIPTDDGDLNAQFDAEMRKFCQKAPEEKREFTASEKQEDYYRGFRSRVVLFWIVCNFGLVALVLSTAGLSRLKSDKKATTQESYAASGVVDNRSTIYLAVVLWSVAGLSAFKFLGSMWFLLVRMFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCQ9</accession>
    <name>A0A0B1PCQ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative kinase phosphorylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCQ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCQ9"/>
    <dbReference type="HOGENOM" id="CLU_061193_3_3_1"/>
    <dbReference type="OMA" id="DLEWWSK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="30639" checksum="19C5B5E859BBE091" modified="2015-03-04" version="1">MDLLSSIRKEGSRGGVNFSWSDVTTSQHRENYLGHSIMAPVGRWQKGKDLSWYAKSDNNSIKEGETIEDKRIRERKEEIRRIKDAEEDALARALGLPVKERNTTGSNAITLGEVNKAVREAGVGEDDEIDTGSRFKIFSGQIHEQQEKVRSPEDLDRKYVKQIEGRRKKSRSPRRERRSRRNRNCSRSPERRNNSKFKESRTRYSKDESNGRRYSGDLSRRINRSESYDRDVSRGAKDSRRKIRRSKSPILHSHHHRKARNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCV6</accession>
    <name>A0A0B1PCV6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative spherulin-1b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000844">
        <property type="protein sequence ID" value="KHJ34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCV6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCV6"/>
    <dbReference type="HOGENOM" id="CLU_063727_1_0_1"/>
    <dbReference type="OMA" id="KRNIWSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF83">
        <property type="entry name" value="SOCS BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="28198" checksum="BD608444B6F7E47C" modified="2015-03-04" version="1">MREMRHNDILLVSKAIAIDPSLRLRRAIYAQDTSLVARILKSHPYLIHNPDTTLPPTAHMPGGLSNSSLHVASSIGCLSICKLLLTLGHEGPPDAPQISLNESYETPLHLAAREGHTEIIHLLCERCPTSILRRDSSGLNALMVAAMGGHDTVVQLLLTYAPGSIGGQENKRIILDAVDKDGNTALHYATMYGHLLVLRTLLAAGADWEKRNCWSWQPVSYSATVQAEVYYKGLVNEAERKKKLRGDPQDSMPGSVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCX9</accession>
    <name>A0A0B1PCX9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chorismate mutase</fullName>
            <ecNumber evidence="4">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000144">
        <property type="protein sequence ID" value="KHJ36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCX9"/>
    <dbReference type="SMR" id="A0A0B1PCX9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCX9"/>
    <dbReference type="HOGENOM" id="CLU_057757_0_0_1"/>
    <dbReference type="OMA" id="FLDWALM"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120284">
        <property type="term" value="F:tryptophan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="13">
        <location>
            <begin position="148"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="30596" checksum="BA94359F891709E3" modified="2015-03-04" version="1">MDTAVDLLDPTQALDLKHIREQLIRMEETITFQLIERIQFPLNSTVYKQGAVKIPKSNLSFLDWTLREREKTDSLIRRYQSPDEHPFFPDALLKPILQPLIYPKILHKNNINLNNKIKRYFIDKVLPSICRDFGREDRGEQAENYGSTVTADIQCLQTLSRRIHFGKWVAEFKYLENPEAFTAMIKAGDRQAIAKAITKPAVEQKVLERIRLKSKIYSTDPCESSDKGPKINVDAVVSMYRDCVIPYTKEVEVEYMMQRLSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY1</accession>
    <name>A0A0B1PCY1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative popld domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000486">
        <property type="protein sequence ID" value="KHJ35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCY1"/>
    <dbReference type="HOGENOM" id="CLU_007205_0_0_1"/>
    <dbReference type="OMA" id="KALSPMC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="554"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="718"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="929" mass="104711" checksum="14E0F0BC0DB4CA01" modified="2015-03-04" version="1">MGSPHTNSGLKRPREASSTKLPQGKKNNIVKKYEKKIDARSIATQSSEAALKNGQLDVEAFLRSREFEIKALQDGMQRAKKNLSKKALQKVPREMRRRTASHNVKRLPRKLQKRAAKDMKFENTPTITANKRKPRTSRARLRTETAKKLSLLSSKKISSSENSDEKCKNISTRLPRPKIRKNQLNQAPILKPRYRKRQINKNWLPTHIWHAKRAKMTNPNNPLWRFAIPITPTEKSYRPTHRAGGLRGAIAWDMSYISTLCLEGSESGLENFLKKIGVTEKWLWEEKGLKWRSGKRSWNGWLSKIVNDKSIFICPSIILWCPLISDNSEERATATTTTKVTATAPTSTNKRSPKKSMRRVLLRIHPSAFLETWTELLRLSKLQRPMIHVQDLRFEIGGIDITGPGSTETLLGILHPYSHMEANIEEHAQTFLSLAGLTNPATLPNGAVLSFSIMDPRLRYPPRTIKFPGTSDEENLNLLQRLSEWPVDDSSGSDSIFDQAIRFKATHLPSQKAINRRKGLAPPGSFPDLTINDPPIPIVLLASRNNKSSSFQGTWTILAPWRCILPLWYGLVHYPLSTGGNPRFGGLQELQQIQFEYGSVYFPINYLATASGYSWEVQERLKNKSEWDKRPKGKKIEWDSLDLGNGRIGEVGRGWSCDFEYLLKPTKFIGEDKNLNDKNKDEAKADQAPLLDLIRCNDFRKLLSNKSTGRPSPNTVAVVHIRLVGRGVARYAARIYRLPSPKLTTNSSDSPNTNFSKTLRQEWLSILSTENKKSCGSSKKAAGPKYAKTHAGRIPLNTPLPKRVRLLAQSLLQQPPLPYPNDNEQKINRENGLGNGHPLVPNTEDLIGFVTTGEYCLTDGKGAAIGNILVSKILDRFRTSDLPLEKCDDGQHNSKCDSSNSFVISKEAKLCIVRNSGESIGRLAFWEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCZ4</accession>
    <name>A0A0B1PCZ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hsp70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000827">
        <property type="protein sequence ID" value="KHJ34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCZ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCZ4"/>
    <dbReference type="HOGENOM" id="CLU_009958_6_2_1"/>
    <dbReference type="OMA" id="MGRCTSR"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="740" mass="80995" checksum="8038DD9300BB220C" modified="2015-03-04" version="1">MSSSSINSRFKVLGFGSKRKSGASTTSSHQDDIVSASTSQLQISQSGGPITSAASSSTSLPINHSTSSVRPPSYTNNFSPAPARAGHQSPMLNNPRNTPSQTINGPPPINTASAAYSSTNLSGTMVGPQSSTSGPPGYGPPQYASIPGSQAVSNIQYSNRNNAVEVEGAGRSKAQLIVGIDFGTTFSGVAFAFATNTEAKEDIITEWPGAGSYTKQKIPTVLYYDQYQKVVGWGPDIADALAPTGYPKPGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAMRSQLQKTLGEVFNREERNIKYYLTVPAIWNDAGKAATRAAAIQAGFLRDENDNRLTLITEPEAAALFCSKAGLLNLKVHDAVLIVDCGGGTVDLIAYEVEEESPFTVSECTAGSGDSCGSTALNRNFSNILRTKIRKMKLPDGSKTAGRVYAKCIMDFENRIKADFRNNNQKWAVDVGIEAEFPEAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRVLQNVLVVGGFGASEYLFQQIKLHVPPQFQSKVVRPMDSVAAIVKGAVTAGITERVVTSRVARRHYLMATLQPFKEGHHPEAYRVPSLDGKDRCKFTRQIFVHKGQRVKIGEPVKVSFFRQVAPGATLMYEDILYACDDDICPEYTKDPRVKEVVTLTSDLSRKSLEKDFERMDTPQGTFYRVYFDIYLTLDGSEFNAELVCQGEVMGRCTSRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD97</accession>
    <name>A0A0B1PD97_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000105">
        <property type="protein sequence ID" value="KHJ36223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD97"/>
    <dbReference type="STRING" id="52586.A0A0B1PD97"/>
    <dbReference type="HOGENOM" id="CLU_013430_11_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="192"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="630" mass="70266" checksum="892B4B1DAD630E83" modified="2015-03-04" version="1">MSFLSAITTPHSNEHDNHKNSKSCSHLRSSSRSASEIKIPHLKQRINSASSFLGNESDFSNHADNSFLREVQRNSSLHPSTAGKNEKFLPISKCEEFQENRSQPKSVKSHQNALPVYDDSITRQYTCDLNLHNEPHDDMFNQCSNNKSSVVVGQKLKMHMESRSRLTNGLLQISLNWPFFHAILSEKDSRRIFYFMSLNFSFMLVQAFYGFLTDSLGLISDSIHMFFDCLALGVGLFAAISSKWPPSPRFPFGFGKIESLSGFGNGVFLVLISIEIITEAIERLLEGRETKRLKELLVVSCLGLAVNLVGMACFGHHGHSGHGCGGHTHDHVQIHSHDRIHARCHDHDNNNGHGHDDSHGHGHGHSHGHSYGHSHGHSHDDSHDDSHDDSHGHSHDHGYLRSYSVISQVDPASHSFSSHECDNSNNNNVSYSNNISLGKIPQTLCTIANVPSFHTHLHTHEDDNLHGIFLHILADTMGSAAVILSTALIYLTGFDGWDPIASCVIAILIFFSAIPLIKSSAKKLLLTLPDDKEYELRDILANISALRGVSSYYAPRFWLVDTNTDCKNQKVYGVIHIIAEQGSDLDDLRKRAQDYLKAHGLDIVIQVENDNDLNCWCGIMSNNRSSIMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDE8</accession>
    <name>A0A0B1PDE8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000597">
        <property type="protein sequence ID" value="KHJ34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDE8"/>
    <dbReference type="STRING" id="52586.A0A0B1PDE8"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_3_1"/>
    <dbReference type="OMA" id="LHHESIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="272" mass="31544" checksum="4CFF004FC266463E" modified="2015-03-04" version="1">MDFAQLALHHESINTSPFELLFGHQPRLSFDWRFSAKPSTAREVLAQHEAKSIIRHIQDAWSWAKSNMEKAQLKKRNDVNPHRREPDFEVGDKVWLNARNIPLDCRSKKLGHQNIGPFLIKRKVGWSYELDLPENLKHIHPIFHAKLLRKDPDNPVPGQVLPDPEELQIIPGEQEYAVESIRAVKLVRGKLKYRANWLGSDEDPVYYPASNFMYSPHLIKKFHTMHPELPGPPANLPQWITAYEEERDDYSELEDDSAMNKRMRAAFFKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ5</accession>
    <name>A0A0B1PDJ5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000403">
        <property type="protein sequence ID" value="KHJ35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ5"/>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="377" mass="41863" checksum="58E84273D2FF8476" modified="2015-03-04" version="1">MSAEPLPKKTCLGVGCENDASSLQCPTCLKLGIRDVFFCSQDCFKRSWSSHKALHKPKNTGHYNPFPTFQFTGPIRPVYPLSERRHVPKSIKHPDYSGDGMPYSEMTFSGRTKIAILDKEGQEAMRKVCRLGREVLDIAAAAAKPGVTTDYIDELVHKACIERNSYPSPLNYRHFPKSVCTSPNEVICHGIPDQRLLVDGDILNIDVTLYHGGYHGDLNETYYIGDKARADPDSIRVIETSRECLNLAIALVKPGVLFREFGNVIEKHAKSQMCSVVKTYCGHGINTLFHCSPNIPHYAKNKAVGSAKEGMCFTIEPMIALGTHRDRTWPDNWTSVTQDGKRTAQFEHTLLVTRDGVEVLTARLPNSPGGPLSDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE47</accession>
    <name>A0A0B1PE47_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ctr copper transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000488">
        <property type="protein sequence ID" value="KHJ35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE47"/>
    <dbReference type="STRING" id="52586.A0A0B1PE47"/>
    <dbReference type="HOGENOM" id="CLU_034763_0_0_1"/>
    <dbReference type="OMA" id="NLHAVKY"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="119"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="43274" checksum="58F5FB49911646BD" modified="2015-03-04" version="1">MKMRPYLCLWAAGLSIAQRQILFSRGPSCSEFKIPVQVNTMNFYINPNVNSTAALNNTMQNIFSGLVNLVSNVTVSGTYNISARYCEPEFRNSSRSNTIQLLVHGITYTKDYWSGLGAPGNGYDGDTYSWIAYASQQGYPTLSIDRLGNGESDRPSGLTVVQMGTHIEVTQGIINALKRGLIGRRAFNKIIYVGHWYGSLIGNLHAVKYPFAVDSYVLTGFTKKIRPSLLPTLLTGEFLPATIAYPEKWSNQALSYFASSSEEGGNKLFFVDQTTDPGLQALNFELRGTVTVGEFISAYASTQTAPVYRGRVFVLTGQNDAIFCSPGELGEGTFAGEGDCGTGLFNLAAQTQQLYPSAAVFDYNTPDETGHCNILHTNSQEQFAIAHDWLSRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE58</accession>
    <name>A0A0B1PE58_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000319">
        <property type="protein sequence ID" value="KHJ35625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE58"/>
    <dbReference type="STRING" id="52586.A0A0B1PE58"/>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="408" mass="47322" checksum="A50B54B197F71E8B" modified="2015-03-04" version="1">MAHRIRPLQRLNWIYTTSRNRSFLNSRSYATNHPKPDFNVYQEEKRKFRNSMIVVVGGGLFIGTLIYSILNGDATKLDEPTIAERDALAKRESGVTDSSPMRLRMEEFIKEQQTEIVRELEKIDGKTFRTDKWVRETGGGGISCVLQDGNVFEKAGVNISVVYGTLPRKAIDQMRVNHKAIDPNVTSLDFFASGLSLVLHPVNPMAPTVHLNYRYFETSNPDGTSNTWWFGGGTDLTPSYLFDEDAVHFHKTIKDACDKHDREYFPRFKKWCDIYFNNKHRGETRGVGGIFFDDLDEHEKDQENTFAFVKSCLKSFLPSYVPIIEKRKDMPYTEKEKEWQQIRRGRYVEFNLVHDRGTAFGLNTPSARVESILMSLPLTAKWRYMHEPDEGSWEQRLVNVLREPKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE77</accession>
    <name>A0A0B1PE77_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nuclear actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000315">
        <property type="protein sequence ID" value="KHJ35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE77"/>
    <dbReference type="STRING" id="52586.A0A0B1PE77"/>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="473" mass="52275" checksum="265794D240E87850" modified="2015-03-04" version="1">MASQPISSSTQPTDVYGGDEVAAIIIDPGFSSVRAGFAGEDTPKSFVSSYYGVTTDGRHLFGDDYIHNPLLGHEILNPMSKEGIVENWDAATQLWEYAITSRLTSLYSSDQQKKRNKNDAKKENEDVETEMEDVEESEKFMEEHPLLMTEPAWNTPQNREKSIELAIESWGCPAFWLSRSNVLAAFGAGKATALVVDVGASMSSAVAIYDGLILKKSVQRSPLAGNWLSSQVRTLFATQDPKLNIVPHFMIASKNPVDMKAPPQAIFRTYDKKPTNSFYTFEEERVITEFKESIVQVWPGPGRLFSGGNANGTSNYDFLKSQPGRLFEFPDGANQMWGAERFAVAEGFYDEKASLTLPGETMPSTKNQTLQEMVKASLSGVDVDIRGALLQNIVVVGGTSLVQGLIERLEQELKQIYPGSRVKINAAGLISERRFSSWIGGSILGSLGTFHQMWISKKEYEEFGAGIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEF7</accession>
    <name>A0A0B1PEF7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2963</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="JNVN01000570">
        <property type="protein sequence ID" value="KHJ35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEF7"/>
    <dbReference type="STRING" id="52586.A0A0B1PEF7"/>
    <dbReference type="HOGENOM" id="CLU_025947_3_3_1"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="229"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="456" mass="52437" checksum="89DC2BEB11695048" modified="2015-03-04" version="1">MDLLQRLARFLDRPFFPWKNLILGFSIGQYVFEGLLSLRQYKVLKLTHPPKVLQNEVSQEVFDKSQAYGRAKAKFGLITGLLGQIQNTAFIYYDILPKLWTLTGSWLLRYFPVRFSGEISHSIVFVLTFIVIQQILSIPSSVYQTFVLEERFGFNKQTPKLFLMDMLKGQMLAFILTPPILAGFLSIVQKTGNKFFYYLWLFGAGLQVFMITVYPITILPLFNKLSPLEPGDLKTGVENLARRLKFPLHELHVIDGSKRSAHSNAYFFGLPWKKHIVIYDTLIEKSSSEEVVAVLAHELGHWSLGHTTKLFGISQAHFFYIFALFSVFVNNASLYESFGFHKNYPIIIGFILFSDALSPMDTFIKLLMNILSRRYEFQADNFAKELGYSKDLAQSLIKLQIQNLSTMDADWIYASYHFSHPILTERLSAIGWYSEQKIVGNDEKDEKTVMASGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFY7</accession>
    <name>A0A0B1PFY7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000111">
        <property type="protein sequence ID" value="KHJ36205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFY7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFY7"/>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_1"/>
    <dbReference type="OMA" id="AKWRAQT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="411"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="470" mass="51407" checksum="8154FEAACDB930A5" modified="2015-03-04" version="1">MHEYRVETDAFGEVQVRADRYWGAQTERSLENFKINQPQDRMPTPIIKAFGILKGAAATVNMQYGLDPKIGKAIQEAAREVADLKLIDHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGKMGSKKPVHPNDHVNMSASSNDTFPTVMHIAAILELENELIPAIKSLRKALQIKTDQFEAQKIIKIGRTHLQDATPLTLAQEFSGYIAQLDFAISRIESSLPDLRLLAQGGTAVGTGINTFKGFDEAIATEVKRMTGIEFKTAPNKFEALAAHDALVQAHGSLNTLATSLFKIAQDIRYLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEALTMVCAQVIGNQTAITVGGMNGQFELNVFKPLIIRNFLHSTRILTDSMRSFEKNLVVGLNANVEKIASILQESLMLVTCLNPKIGYDMASKVAKNAHKKGITLKESAMELKALSEDDFHKLVRPELMIGPANYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGH0</accession>
    <name>A0A0B1PGH0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2850</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="JNVN01000312">
        <property type="protein sequence ID" value="KHJ35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGH0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGH0"/>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="OMA" id="NAMVRDC"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="553"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="730" mass="82994" checksum="D5C9A907BFF8ED57" modified="2015-03-04" version="1">MMQHSLQWESSRIMVYDYNRFDKIQKTLSWKRRLIYPRKLNYFSTNFVDHSKQLREQMAKEHVKNILKKQQAYKDAIAFKTDFIFSVLNSSATKRDAKSYIQRFALPDSKHNLTCATKRRPKGLSYANLGMIYEPAAILDSPKFIQKPAQSFEVVKEIQRHLAVVKIRAIQNLSDKTVNGIGRTIHQLSRLGLNSIIVLDFNSENRRETNFTKRDTIRLKLEVEQSNRIINAINQSGENIARLVDNIVGVSENFNHAAKTFIALPELLATQLRRGIIAVILPIGYTNLTIKSLAVPANEIVLALTRELGGFSSYLPQENNSRDSLNNHRHILSDDNLLDRLIMLDPLGGIPTPDLCHGYHVYLNMIEEYDEVRQVLLQNLPHEPGLEPPVVSSNVLRIEDELLSSQNTETRSKVSHTHSNSNEKKNGLKPVTENFHHLENLKLTRDVLSILPPSSSALLISPEEVARSVNDTSHRPGFVGTRRQKNPLIHNLLTDKSIFSPSLPSGRRRKKSITSESDHVFDEFVMPITFAKHGIPVTIFPDPKIAPWTPKTGPSNLSLTNSDINLPLLVNLINDSFGRTLDVPAYLARVENRIAGVIIAGEYEGGAILTWETPPGMESTDTSCMVPYLDKFAVLRRSQGSGGVADLIFNCIVRKCFPNGVVWRSRKNNPVNKWYFERSRGTWKLSQSGWIMFWTTPNMTLHQNEQLLLNYEGVCRSIQSTWKEENQKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGU0</accession>
    <name>A0A0B1PGU0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="JNVN01000283">
        <property type="protein sequence ID" value="KHJ35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGU0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGU0"/>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="432" mass="48832" checksum="C4E844A1E6C24004" modified="2015-03-04" version="1">MSFTQTSKKSDRWIYLENIFRNPGAFTDEDFDTSDNTLARIERMKLLWDISLVLGAGGLGCEILKNLALSGFKDLHVIDMDTIDVSNLNRQFLFRQCDVGSYKAEVAARFVEKRINGLSITPHKCKIQDKDDEFYMQFNIIICGLDSIEARRWINSTLIGLFDGENPDSLKVLIDGGTEGFKGQSRVILPTLTSCIECQLDMHAPRAAVPLCTLATIPRQPEHCIEWAHLIAWEQEKPYPHLDNDDPVHITWLYQKALERAMKFNITGVTYSLTQGVIKNIIPAIASTNAIIAASCCNEALKIATGSNPSLGMEENYMMYSGNDSIYTYTFKHNKKDDCPVCGVLARDFKIDPDITLEEFIKSLAERPEAQLKKPSIRTENKTLYMQYPDSLRVQTTPNLSKKMRDLISCEQEIGVSDPSLAGISLRYRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH54</accession>
    <name>A0A0B1PH54_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative n-terminal acetyltransferase a complex catalytic subunit ard1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000122">
        <property type="protein sequence ID" value="KHJ36171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH54"/>
    <dbReference type="STRING" id="52586.A0A0B1PH54"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_0_1"/>
    <dbReference type="OMA" id="LPENYFM"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000085">
        <property type="entry name" value="Putative N-acetyltransferase complex ARD1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="26672" checksum="7AF0A74559379801" modified="2015-03-04" version="1">MDIRLMRPSDIPHIQHANITNLPENYFMKYYLYHALSWPQLSYVAVDVSHPIKSPYDYPRIVGYVLAKMEEDPADGVQHGHITSLSVMRTHRRLGIAEKLMRQSQRAMVETFSAKYVSLHVRVSNHAALHLYRDTLGFQNDKIESKYYADGEDAYSMKLDLDFIQQIVSDEMQYIDEGDPIGEIGNEKETELAVRIKEDEQLKHVGGKKMKVRVGRGLGVGDLVERDESHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHD5</accession>
    <name>A0A0B1PHD5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5593</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000187">
        <property type="protein sequence ID" value="KHJ35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHD5"/>
    <dbReference type="STRING" id="52586.A0A0B1PHD5"/>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="OMA" id="IYHTPGG"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="15">
        <location>
            <begin position="76"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="30168" checksum="6000B8873B4D1CE9" modified="2015-03-04" version="1">MVKWPPWSEREADKKNSILWLDNLNTTNWDHYTDPRTIVPTVLLTTVILVSSRIHRTYLRRIPEAKYISPRFFRNRSLFGTVTRVGDADNFHLFHTPGGRLTGWGWFPGRKVPENKMKLRGNTIHIRLAGIDAPELAHWGKPGQQYSVEALAWLEKYIGNRRVRAYIHKKDQYERIVATVWIRRFLLRRDVGKEMLKAGWATLYEAKTGAEFGGFEQEYRKAEEMAKLKKVGIWVRNTKATESPREYKRRISSTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHP2</accession>
    <name>A0A0B1PHP2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHP2"/>
    <dbReference type="HOGENOM" id="CLU_2211916_0_0_1"/>
    <dbReference type="OrthoDB" id="3489571at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587910" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11705" checksum="D26410B32ADB1CD7" modified="2015-03-04" version="1">MKGLVLLALFSVASASFLEKFGLNIFSSKKPHGFGICVNTIGGSYTYNDAATRTACEWHNTKENNKCVDCIIVINESTHCSSEKKQLDKAEFHNLCKDAGADRSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVZ2</accession>
    <name>A0A0B1NVZ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative vacuolar sorting receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004997">
        <property type="protein sequence ID" value="KHJ30143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVZ2"/>
    <dbReference type="STRING" id="52586.A0A0B1NVZ2"/>
    <dbReference type="HOGENOM" id="CLU_064145_0_0_1"/>
    <dbReference type="OMA" id="RTKSTIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080358" evidence="10">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="317" mass="35664" checksum="CEBCCE79FA646292" modified="2015-03-04" version="1">MFFQFFLHFVLIYGRISAGASDKESTSPAKTVKPCTISSPTGIFYDLNELRVTIPKDPKKAPKGTRIEDWKVRGYDYHNNQANFTLNVCGSLAEKQSNFVGVEESLWQNVSAYYELGSERFSIGQENSTLKLRGRRLVLEYRNGSPCGDRGTSRKDGYDQIRRKSSLISFHCDKDPLAAPSSGIFTYVGNSDDECSYYFEVLSKVACMTAEPTKQSIGPGAVFALIFIIAILVYFLGGIFYQRNVAHARGWRQLPNYVIWAGIGNFIKDIFTAVTSSCSGFVPNRRGYSMLSTGRGFHSRAEDENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWN9</accession>
    <name>A0A0B1NWN9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01004384">
        <property type="protein sequence ID" value="KHJ30368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWN9"/>
    <dbReference type="STRING" id="52586.A0A0B1NWN9"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OMA" id="CREGIRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000014">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="54126" checksum="74E65FA0956E0359" modified="2015-03-04" version="1">MAQIKIQKLFYDGKIQDASSGKKFQTIDPSTTQVLADVQIASKADIDAAVASAEKAFSSWSQTSAIFRSRILLKAVAILRSRNDVIARVETNDTGRPFTETSTVDLVTGTDVLEYYANLVASGGLNGETAQLRPDAWVYTKKEALGVAVGIGAWNYPIQIALWKSAPCLAAGNCMIYKPSEFTPLHGNILAQIYTEAGLPAGVFNVVHGDGDVGSYLVSHPGISKVSFTGQVSTGQKVAASAASGMKHITMELGGKSPLIILPDTDIEKAVDVAMMANFFSTGQVCTNGTRVFVHRTMKTAFERRLIEKMYYVRSLPPMHEKCNFGPLISEAHFRKVIGYIRHGISVDKARLIYGGANKPSNIPPPYTNGYWVQPTVFTDCTDDMKITKEEIFGPVLCILTYDTVEEVIKRANDTKLGLAAGVFGKDINKCHHIIDRLKAGITWINTWGESPAEMSVGGWKMSGIGVENGRRGLDAWIREKSTLVEGSGVIETAFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWZ7</accession>
    <name>A0A0B1NWZ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative yippee family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003495">
        <property type="protein sequence ID" value="KHJ30877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWZ7"/>
    <dbReference type="STRING" id="52586.A0A0B1NWZ7"/>
    <dbReference type="HOGENOM" id="CLU_043857_0_0_1"/>
    <dbReference type="OMA" id="IGKCENR"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="103"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="32418" checksum="542999F1A56B8C58" modified="2015-03-04" version="1">MALDALPPFVTFLLPTPRFPYRKHSPSLSNGSTLNSSCHSTSSFPSPSTPNTTPISSATGSSLTVSPCESSSSCNLPCSSLETKKSPSSSSLTSIRLTRRYPSTLRCLKCSTDLAYTTQILSKGFTGRLGRAFLVAPPPQPPFVPSFPPKPRPKAELVNTRIEQPMSRELITGWHVVADVSCIVCATVVGWKYIEAREDSQRYKVGKVILERERVCVSGTWEDIETFEAQETDSKVGAIKEWAYQESDSNIQFDSEDEEERESLFSGVWDRDVVARRRSKKLAKKKNGKEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX09</accession>
    <name>A0A0B1NX09_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004090">
        <property type="protein sequence ID" value="KHJ30513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX09"/>
    <dbReference type="SMR" id="A0A0B1NX09"/>
    <dbReference type="STRING" id="52586.A0A0B1NX09"/>
    <dbReference type="HOGENOM" id="CLU_022916_3_0_1"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="144"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="10">
        <location>
            <begin position="380"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="514" mass="57241" checksum="009C35105B118982" modified="2015-03-04" version="1">MGDPRVSSSYSVKPKIRYNTIGGVNGPLVILENVKFPRYNEIVSLTLPDGTERSGQVLEARGDRAVVQVFEGTSGIDVKKTKVNFTGHSLKLGVSEDMLGRIFDGSGRAIDKGPKVLAEEFLDINGSPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVQKQGVTNKGTHDGHEDNFSIVFAAMGVNLETARFFTRDFEENGSLERVTLFLNLANDPTIERIITPRLALTTAEFYAYQLEKHVLVILTDLTAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVQGRNGSITQIPILTMPNEDITHPIPDLTGYITEGQIFIDRQLDNRGIYPPINVLPSLSRLMKSAIGEGHTRKDHGDVSNQLYAKYAIGRDAASMKAVVGEEALSSEDKLSLEFLEKFERTFISQSAYESRTIYESLDQAWGLLRIYPKELLNRIPQKILSEFYQRSSDRKAKGRSNKDTRDNTEEAKKQVQEENLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX44</accession>
    <name>A0A0B1NX44_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004022">
        <property type="protein sequence ID" value="KHJ30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX44"/>
    <dbReference type="HOGENOM" id="CLU_114242_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="18129" checksum="3AE8F7035186855C" modified="2015-03-04" version="1">MASIAARNAPKSGKLSEWTILAGNGPKKNINIKSGTTFPPPTKTSEESKRRVIFYRQEGTPARSSKTAQDKLHAVNMKLLSLKVPAHIRFVNLRHNERGNLTGLTTAQTTAEAMLPRVKEVCLQTALRFDGDITDISVNQQWINLKAYGVELARYHFKIMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYB4</accession>
    <name>A0A0B1NYB4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative guanyl-specific ribonuclease f1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005567">
        <property type="protein sequence ID" value="KHJ30030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1090683_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="28979" checksum="9FD6B1A7811F3425" modified="2015-03-04" version="1">MDPSGQLKRVIARTYDHDFVDCIASSTEIPAHVSHSNGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCLLWPLKPSGSTMRNGNLTPFRLVMSFDFQILFVALKGHNKMKKCEKRTIAGGNINHDQSSFRCGKMVFHNSELLAVVHKACKEKMLHSKTYPMSYEGVIFQVPGPYLIYPLMKDKEYNRGWPGMYFIVMNYDCVLAGALTTRKRKMPQTNSDSRKISKTLVKCIPFRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYS6</accession>
    <name>A0A0B1NYS6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004831">
        <property type="protein sequence ID" value="KHJ30190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYS6"/>
    <dbReference type="STRING" id="52586.A0A0B1NYS6"/>
    <dbReference type="HOGENOM" id="CLU_031753_0_1_1"/>
    <dbReference type="OMA" id="VWDVEPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058770" evidence="4">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="46122" checksum="94F567F1F00878A4" modified="2015-03-04" version="1">MLLPIFLLGASVIGCSHANYNIPNTGSYSQSLIEPDQDGKYTIKGTEIRASFVPYGASISNLFITDIHGVERDIIAGWDNASYYTIDRQHPHFGGVPGRYANRIKNSSFVIDGETYHVLPNENPTFENPNGINTLHGGPDGWDWRNWTVTELLENSITFSLTDPDGKEGFPGEVISYVSYTLGNMTWEFRMTALSTTKKTPIMLTSHTYWNLDGFANNDTETALNHTLWLPFAGQRVGTDTILIPKGDILDNVQGDPNDFWSAPKEIGANLTSPSMLGNCGYNCSGYDTCYINNRRPYSLKANWSSNELPVARLQSSWSGIQLDLFTNQDAMQVYSCQGQNGSIALKKTQGRPENRFIQKYGCVVLEPEDWIDGINYPEWARKQIWGPEDGIYTVEASYRFSLNSTMAMNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYU5</accession>
    <name>A0A0B1NYU5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative gpi transamidase component pig-u</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004800">
        <property type="protein sequence ID" value="KHJ30205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYU5"/>
    <dbReference type="STRING" id="52586.A0A0B1NYU5"/>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="47039" checksum="C5D170870D086945" modified="2015-03-04" version="1">MLKGGRKLTLFAVGAAVRILLFTLFVGLPDLLTARVEISTPVTSFKRLQEGLYLYKHNVSPYDGGVYHQAPLLLPLLSLLPDYSIYPAFTNLLYILMDLMSANSLMRIADSGEAASSKLYTSPRKNKGWSSLAVAAAFLLNPFTIATCIGRPSSVFTTCAILFAISKAVVGASFSSMFALSIAGYLSLYPILLFPPLALLCFDRRPLYRTAETLLSFLVGNFLAVAGSLYVILQMSSVITGSWEFLSSTYGVQLLLPDLTPNIGLWWYFFIEMFDSFRNFFLGVFWVHLSSYVIGLTIRLRRQPLFALTILLGIFTIFKPYPSISDTSLFFAMLSLYMHVLPLMRYTFLALSTLLYATFLGPAFYYLWIYAGSGNANFFYAITLVWSLGLSILTADALFAVLRDEWEVERPEMAGKEVQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH4</accession>
    <name>A0A0B1NZH4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mitotic checkpoint protein bub3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004256">
        <property type="protein sequence ID" value="KHJ30435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZH4"/>
    <dbReference type="HOGENOM" id="CLU_038526_0_0_1"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="39038" checksum="F46EE516793604F4" modified="2015-03-04" version="1">MAPALQFELSQPPTDAISSLAFAPHSPTRLIVASWDKNVYLYDTSDQEAQGKLIRKFEHRAPVLDVCFGASDNEAFTGGVDFQVKKIDLENGDQTVLGSHEAPVKSVVFSKEKSLLFSASWDLTLHVYDIDNLSSGVTEIILPAKPHSLSLTASKLVVAMASRLVHIYELEVIKSNIEKSTNDTMTVIKPWQQRESSLKFMTRCLACMPNDAGYATSSIEGRIAVEWFDPSTESQARKYAFKCHRQPDPDEEGGDIVYPVNAVIFHPVYGTFASGGGDGIVALWDAEAKRRIRQYQKYPQSVAALSFSCDGNYLAIAVCPGFENSQEDYSGEGRTHIYIRELGVNEAKGKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH9</accession>
    <name>A0A0B1NZH9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005220">
        <property type="protein sequence ID" value="KHJ30086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH9"/>
    <dbReference type="HOGENOM" id="CLU_1826725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="16013" checksum="D09377BDF43628B0" modified="2015-03-04" version="1">MKCSNYLIALAKERKEQENAIFDFISKRERCWEEVRNASSWAKQVSKDRHDLGIRKELNFIDGSMVMLYDGKSAKKQLHPSYRGPFVISGKGGSHGKLYTLKQINGTPIPGTFYGDHLKPFVPRTGHLITSNEEEITLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV4</accession>
    <name>A0A0B1NZV4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sec7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003968">
        <property type="protein sequence ID" value="KHJ30570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NZV4"/>
    <dbReference type="HOGENOM" id="CLU_001772_0_0_1"/>
    <dbReference type="OMA" id="WTPPTQN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAP-C" evidence="3">
        <location>
            <begin position="843"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="858"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1631" mass="184067" checksum="6A126DDBEE73B7B5" modified="2015-03-04" version="1">MRTMLLDEEDEVSTRSRASPCDAKFFLRLDTTLGKTPKDTFSPTRDDENGCAAHTDEQQIFKGSFFNDTTPLSSPRIVENNNSAANQKRYSHELALSPRRAARESLVDHMLLSFDQLKTNHFAPNQAIKKTVGRDFFEVEENIHRAFDDNDSYQSINIPTSHDVRGMKNKTSYIYDAEDFNEVGIYSDQKPNLHQRSSESQFKTSSDMIVEQKLDPLVGYQRLLAQRKSKRSKSHSGSRENKNKSYTDFDYFEPISYQKWARNQSSRSSSFDYKSGFNDARDFNVRGDWNTKYESYQYHIEPHPTKHYSSERDRDASPARTPYSESTSFQKFYPKLETKISIKSMKNTVGQRLPERSDSIATFTASTGPKESFERIENLNQSRKLTHTPGSNKKRQPSHAKLKKESPPSTNAPLPTLPVNLSIQSKDRPGFFRRVFGSSKNHVRNNIHGVNLDNSPPHGSSSSIETVDLPITNPQPIDVKRNSEAQNREEIVSVSHPSPSIPKNLMPRRSSTTTAPEELMPNVDRKPSSFFRRRKKSYSSKATNALANSQTRKAPNDEISFDKVLPTPPTSLPSVLHPYLQTLNPSIDIFSSQDLEDQHDKNNQDTGNDALTSFSPSYDPIPSAKIRPVKECVEETHQNLGLSSILAQQLLKSSNRSRSPTAVFKDSGTNQNSMFYQENNANRGDTSEFNSSYVNHLATHPIGDKSPAYMDRKYVPVSIPTYKNFESSDDGEYAWSRSHPLIPRQQMTESASSIKRTHIARQHSEDWVKISGSKTLTAIEKDDRVWLEPSSDEEESLSSQAGTAESVLLSVQRARSDSKASIDGSIGSITESFEDKKFKLDRPFKNEFTPTVSSDSNINIVYENKISDKNVKDYEIAREIFDGNENSVPKDKAADWLGKEDISFKKILEFYFDLYNFKHLNVLAALRKLCGRLVLKAESQKIDRILLAFSSRWCECNPHHGFKEIDVVYTIAYSLLLLNTDLHVANIEQKMSRTQFIKNTLPTIRKIIIHTFPHNSESTRPTILPGKCVAFENTLDNQEVKIDELLGTEKTSWKSYVKTTAPKSGTDLVSLTSHENENSIDDPGPLVEAPFYGTLRSWEVKLEMILKTSYNSIRNDPLPLYSQHLEKSAVLDPQSKNNLSGTNNNPLRRTPSILSHTPSDTQSYRSRVADSFLRVGNGKRMNKIRSRPRLYTAGSGIGSSRTSLDDQSSIMSPVSSTWSKYSLGKTQTSVSIDSMGSTWPNEKFQQSIGFANAISQAIIREEMVGSPGNMFHELDDINQTPLLEDDSLELHGAPWAKEGLVRHKHHLESLDKRARERNWTEVFAVIEKGYLSLFTFPNKSRRQKTKDKNSPGVVGGGNWQENAQNLGSFLLQQTIASALPSPGYSKARPHVWALSLPTGAVHLFQVGTPDVVQEFVSTANYWGARLSNHPLVGGISNIEYGWSDAIINMFDNKSQLCAKDAPKRPTTSSRNRPSISGQNNGPNIGRLSLDLGTSGVPRPRIFDEKIMISEWTPPTQNMRASNLPEQEQLSALTAYVSGIEEELQEHNKLRGPMLLAFCPRQPNAQKAMANWEKKSAYLLREIVKFTTYIDSLQAALTCKRKIYEEREQKLTENEPVIQELSHSDILMTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0B8</accession>
    <name>A0A0B1P0B8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative snare complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002662">
        <property type="protein sequence ID" value="KHJ31688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0B8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0B8"/>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="OMA" id="NRKMCII"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="228"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="37061" checksum="B5036CEA7F93EAC0" modified="2015-03-04" version="1">MWRDRTNLYISYRQSYAYHPVKKPEVSSPNYGYSSTISSERQGLMSTGAYDDGETVIEMDLLPPRWADISDQVTEILKNVAFKGQKLDRLHQQHVLPGFNDEDVKRQEEIEIEFLTQDITKSFHECQRAIQKIEVLVRESKAQGGISKGEEIMARNIQISLAGKVQEASASFRKKQSTYLKKLRGASGINAPIDGTSLNTFSDRSVQETNADKHYSQLTLQKTSDFSDAIISQREREINDIAQGIIELADIFQELQTMIIDQGTMLDRIDYNVESMSNNVKSADKELNVAISYQKKGTRRRAIFLLILLVLGMFILLMLKRKNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E4</accession>
    <name>A0A0B1P0E4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002322">
        <property type="protein sequence ID" value="KHJ32122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E4"/>
    <dbReference type="HOGENOM" id="CLU_850449_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="36686" checksum="00C01CC87B51FA23" modified="2015-03-04" version="1">MKQGQQQTFAAYLNDFEYMLAQAKDYLISVKFPKDNYTSYVNEVKSVAGKLEAKENYVPKYGAKYTETWFITRAGTISHNQESNNRISQKTSQKAFQDPVLTELDADGDTPMSEINGVNLSTLTAIINAIKSQNQCESNKGKTKPPAPWRSPDEFAELRAAGKCTRCARKGHYFKICPSFTWAKRPTNVNAILNTNPSISQDHIRNSDNEDFSGKELTGSFIVRAKGWDKFQQQKLKVKLESLKIKSGTARQVTGTEFQDIADVSNTSANVGLKLFGASIADIKKALEVKRKQSPEKLKQVCLIKYAKMLNSFEKTMYTSCRPIDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P148</accession>
    <name>A0A0B1P148_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative myb dna-binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003826">
        <property type="protein sequence ID" value="KHJ30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P148"/>
    <dbReference type="STRING" id="52586.A0A0B1P148"/>
    <dbReference type="HOGENOM" id="CLU_436281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="627" mass="71619" checksum="FEBAB72113BCAB68" modified="2015-03-04" version="1">MAKSRFHHELGSEYQLKTIHREVPMSFHREKQDLLQINNCKLKPENQPYSTKHLNLRPKSEQHETLTSFKYDLNCSSSNNDPSMLAPPLLESKRSLQEQQFEPHQLRIHHSMLNSMTSNNLSGKYKDKESPKQALPRVTIEIPQGINSSSRPYSNSGVHKSEVVRKTSNIMSLLNEEEPSEVCSPLKNVVDTSSPLQKLQTTTSYQLPSVSSYQNTSSQHLVPALPQISQAITQPYVQNIQQFSHQIPQKLSPVVKQSRSYIPSSGNYENQGYVPPSTQSRSQKIYQNPSKQSQCQQISSKSPTPIHRDVSRNEIHTIASSYSCSPASSNQKSTSRLNEPSYSKNPSSPLAQQSRSAISPIDLANTDLEYYRNQRHSTPSTSQVKLLSHQVQQHQQYQQQQQQRQHHYQQNQKQQLQQGHSASIVAPSSFQPSGSILQNQNHFQENLRHAHVSHSQGQPQQQQPRSKSVGPNQIPLGHISHSNDNGNEIANQSRQYFTQISPNSHSPHSHINQGRQESLSENRRSRRSSFEKRYDSQIPSSTVSQNSVQQASYSISPQGSISSIYSAPNQKTSHNNSLDSHHTTQRREVTDNYIHFERRLQDEHFNETRVRDQERGRDRERHLHSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P156</accession>
    <name>A0A0B1P156_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative mfs transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002157">
        <property type="protein sequence ID" value="KHJ32342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P156"/>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="OMA" id="FTWLWQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="580" mass="63993" checksum="EF6CA1BC713B5BC9" modified="2015-03-04" version="1">MLHSALASPKCSKDEPSKTPTQHYLTFPTPPPKSRGRPPISPTRSITPDSFSGSNCCEEWDCSTWNSSIPKKQLLLLAFISFVEQTALNSMSPYLPEMVTTFPEVKFQDKGIAVGTLGSVFALSQFATNFFWGWLSDQIGRKPVMMIGTISTAACFFAFGFCRNLWQAILIQALMGLVNGNQGIISSCLGEITNKSNQSQVFVYLPMVFGIGAVTGPALGGLMIFQRNPFKKDQKNPFPFLIPNIFAAIILTVTSVLMACLLEETLVKSEGSESIRKRISLFFRQFWKLLLKFRTNFSCNLTSKSPEALSYLDENINENLNPNEDTSLLSNSVIYSDFEDDTIFKSRTSKMILCRDTLILLGTYLVFQLSNVSFNSLYPIFLSEKEPVGRNLSVESIGLSLSVSGIIAIIFQGIFLEQLKHKIGNKATYRVGLFFLSISMIAMPWISYSHSSPLIECGNESLWFWIELGFLLFLKTIAFVGGFTSALLLITNTAHSHSILGTLNGLAQTLSAAGRAIGPILSGSLFSAATRKINSRGILPWTVFGGVAFLSFLASFGIKSSDLESELRNEQISQNEDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P184</accession>
    <name>A0A0B1P184_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative urease accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002417">
        <property type="protein sequence ID" value="KHJ31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P184"/>
    <dbReference type="HOGENOM" id="CLU_053180_1_0_1"/>
    <dbReference type="OMA" id="TKHEKHL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="270" mass="31100" checksum="8AB93B258C83466F" modified="2015-03-04" version="1">MPKKHTRKGEISKSLVNLPPTQLAKPLPVNKSARSNGIFSSEVNPVKKPNKKRKRKNTAEDDTPKAFLRLMSIKQGKKLPKALDDGIETIHDKKKRKYSKDEAKQQIQKKISETESLKIRPGEKMSEFGARVDAALPVKGLINRSTRKGLNTIGSKYSQTRMEKRMHKMYDQWRLEESRRKEYKLKMLEIAEEEEMDEDGQVKWKIDILTNPKGKKSKRKSKRKNFLGEIDDGEDDPWAQILKTRGETKIGMHDVAQAPPTFSNLPRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B9</accession>
    <name>A0A0B1P1B9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003867">
        <property type="protein sequence ID" value="KHJ30619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B9"/>
    <dbReference type="HOGENOM" id="CLU_086393_1_0_1"/>
    <dbReference type="OMA" id="YIEMWDY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="157" mass="17921" checksum="50520E79A61D33FB" modified="2015-03-04" version="1">MRVVFLGEEGRYTDNGSYDMIASKPVSGKNTLYTHEKRQCTKVGAYFEMWDYVGGSSFRGFVGGHGNKQGLFIFFEKSIIHKDLKRGLMALIDFAEVVFDVAQITMCLDRSIPENETKFLLKSLSWVGFKPVTLESRINEIQTSDISSKWFFLGMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1T1</accession>
    <name>A0A0B1P1T1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ifrd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003079">
        <property type="protein sequence ID" value="KHJ31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1T1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1T1"/>
    <dbReference type="HOGENOM" id="CLU_039188_0_0_1"/>
    <dbReference type="OMA" id="HISGRHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="434" mass="48859" checksum="88A629F26F4CB264" modified="2015-03-04" version="1">MRDLRGQALESKKTISRKAQLRESVRTSHGLNLRSNPRGDPRHGIDSKSNGSDHGDLTEVAVNDRKSLDSSVKNSDSWILEIEDLLEEIKEKKRSSTKGREKALSRYANILMNHYAFEQIAGKSREIFPALLKSIKGENSEKEASNALLAMTLTVITVPLEVNYDSVEQELKRAYKNSKLNHVKAFAIQCLSVIAPYAGASEFEIDEILDELIEIVESDGNSIDAPDSVEVVVAACEAWGHMATYLDDLENKTEIAMEAFMEQLNSSDTNVQIAAGENIALLYESSFTEREVEDGPASKIYDNEGFILDSSQVKRYEVFPQKEQLLYILNGLKNESSKQIAKRDRKNLHSSFSDIINTIEYPSRGPRFQNAINAETGNRYGSRVKVNVRNKGYFEIDKWWKMFRLKAIKEVLGGGLLIHFQQNDTIIDTIGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W1</accession>
    <name>A0A0B1P1W1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001918">
        <property type="protein sequence ID" value="KHJ32642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W1"/>
    <dbReference type="HOGENOM" id="CLU_861058_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="36419" checksum="DA67D877A4DA62CC" modified="2015-03-04" version="1">MEVNSITYITLDLDGHLTSKLWLAKVWQQKFRNVARPKVTSAMAMAMASLIKEIPFCKVPLEDINKVLRSKPYTSLKEARERLPELIRDYTHLFTDDKNNGNTDALLQDFWNFTMDEETDVDIFAHGLTKIQSNIALVDPGQRPSGTIRKNRLLNHFNQIKDGRYSGCVSSLRLNAQLSFEDCVNSLRSTQGNIKRFEVKIEPSIMLARGPDSPRLKVCAHCKKGHIRESCFIWIDTPDGSKWAAKNPGKASNVLKRKNMLTKKRLEVNDEKDRSGSAFDGVWMMGDNSSPTKSDLSSSVVLDTGATHHIFCDQSAFLSLSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P248</accession>
    <name>A0A0B1P248_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003352">
        <property type="protein sequence ID" value="KHJ31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P248"/>
    <dbReference type="STRING" id="52586.A0A0B1P248"/>
    <dbReference type="HOGENOM" id="CLU_009486_1_1_1"/>
    <dbReference type="OMA" id="CCEFTGY"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="129"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="573" mass="64315" checksum="5C0D496C1FDF2D9C" modified="2015-03-04" version="1">MSDVKPATEWTLRNYTKIKRPFVQLRAISTNTADAFKSSLSSRGEQIPESNSSPTLDAMTKVTKLAGSLSLSLRNSYSDDEGNLSTLPDPRNKPRSLSTEIPTQNSHHPDLSSEVTALSNKLINAINHQTSLDDILSATQHELTALQERSKFLERENKKYVDLLEQGFLVKKSSVDSLKAKLNATILEERRRREEVEREKEVMEQELETLTAALFEEANKMVTNAREEARRENYEVQRKNDQLKAQVADNESLMVSLQDQLSELKQVMEQMTMEHDDQTYQTSPSSPGFSKSYSKGYQTDDTDVTHLPPYHEPATPTHPTNLTHLLQTVLRTDLPSYHEFISLLRTSKNGTAGNRTSTGSYSSIGVSLGLANHSGSLNNSSLPLSTAATLPGTPNTPASTTNSHYTAGHGSATPLKDTKFYKRALVEDIEPTLRLDNAPGLSWLARRTVINAVCEGTLIVEPMPSSSKNVAYSCALCGESRNEPEYIRSYRFKTNENENAQRYPLCKYCVGRMRSTCDFLGFLRILKDGHWRCDDEESEKSAWEESVRLREQMFWSRLGGGVVPVVHQWDKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P251</accession>
    <name>A0A0B1P251_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002935">
        <property type="protein sequence ID" value="KHJ31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P251"/>
    <dbReference type="STRING" id="52586.A0A0B1P251"/>
    <dbReference type="HOGENOM" id="CLU_007818_1_0_1"/>
    <dbReference type="OMA" id="CQANGKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="36914" checksum="F965A9FC98EB2476" modified="2015-03-04" version="1">MLIQKQLILISFLTNLKEQVVNFASATDVCQPINGTTLVYCPEIEEDIIKCQTKFGKTILLSIGGSTYSENGFSSMEAANIAADKVWANFGPLTEDVSVTRPFGKAVVDGFDLDIETQVLNMVPFVRRLLDHLDISRKSDSRKFFLTATPQCPFPDTNFGPLFDGSIYFDAIWVQFYNNYCGADKFIPGSASQPFFNFATWNDWAQRTFPNQDVNIMLGISGGEKATRTGNISKENTTALIEYSNEFPSFGGVMIWEMTALFNNENFLETVSAVVKSNEKKINSDLATSLPASSQQNSSPEVTVSSDASAIHWFSSITWILYISIFLALKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N3</accession>
    <name>A0A0B1P2N3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003466">
        <property type="protein sequence ID" value="KHJ30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2N3"/>
    <dbReference type="HOGENOM" id="CLU_2759702_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7883" checksum="926A88267C6855FA" modified="2015-03-04" version="1">MEWLDAKNISFISEIDAPTHNRVNMLDLCFSSHPLLVKGCTASVQQDLDVTSDHLPILALVPLELPFRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X2</accession>
    <name>A0A0B1P2X2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative micro-fibrillar-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002681">
        <property type="protein sequence ID" value="KHJ31675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X2"/>
    <dbReference type="HOGENOM" id="CLU_022379_0_0_1"/>
    <dbReference type="OMA" id="YRDMKTE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="426" mass="49813" checksum="23A6E27E042F285A" modified="2015-03-04" version="1">MPSKSMTANPIRAPRHRPGIAVAESDSSSEQESSDDENPTHSNKPISQPPKVTTAVGITSHLKKSGYEEHNLKATLEESIRLEEQQKKLVLEEKEFVTESSEEEEEDTEEEETSDEEESSEEEVQKPILLRPVFIKKENRKKIDETVTESQKHDKNIEAENERKIEVDQIVEEQIQKDLVAKAAGKKFWDDDDEVDEIDDTDDIDPEAELAAWKLRELKRIKREREEIEEKEKEREEIERRQNLTAEERKKEDDEYIAKQKEEKEGRSKMSYMQKYYHKGAFYQEEAEAQGLLQRNIMGAKIQDEVDREILPKYFQQRDLTKIGKKGATKYRDLKSEDTGQWGQFDYRTHRNSSNIFNTDERFRPDRDKPQHTATGANSLSISSQNFSKNNSQVSQDTNRQKRCISSERKIDDSHKRHRLDSSSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P327</accession>
    <name>A0A0B1P327_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative tbp1-interacting protein tbpip</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002627">
        <property type="protein sequence ID" value="KHJ31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P327"/>
    <dbReference type="STRING" id="52586.A0A0B1P327"/>
    <dbReference type="HOGENOM" id="CLU_063266_3_0_1"/>
    <dbReference type="OMA" id="QKYHREW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="8">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="278" mass="31929" checksum="9B319DD1106A4942" modified="2015-03-04" version="1">MPPKKHKLDDGEETDSASPSSQKIKKETIKSTKVKTEKKPKIEKHKKEKLEGKKTEINAPSKCGKEVKEKVLALHGDEAIELILKYLRDQNRPYSATEISANLHGKVGKAVADKLLKEMSEMGKIKSKSTRGNEKGSQWIFWSLQDSTDNIGPEDLNQMDDEIKELKENIKELKVKLKANTKILETLKSTPTTKELISNIEKLRIENNAKKERLHEYKNGENKIVTREEMSKVDKELVYWTNKQMARKRAFQCLEDLLLETKTREELWEEAGIEEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P394</accession>
    <name>A0A0B1P394_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cell cycle control protein cwf19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001841">
        <property type="protein sequence ID" value="KHJ32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P394"/>
    <dbReference type="STRING" id="52586.A0A0B1P394"/>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="OMA" id="FMKCLTR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="5">
        <location>
            <begin position="410"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="4">
        <location>
            <begin position="544"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="652" mass="76395" checksum="AECD14769661D113" modified="2015-03-04" version="1">MESLEDFEKHLANKRRHKEERRERERKRHNHHSKSLERHRSKRSRQNYDDDYDENKSKNERTSYSQSELSESKEEKISKIRRDDWMISPPKIELDNVKKKNTREIERKQDHNLIIHKNELNRTLNEPANREKSDQILNSNIVTTPEVSYTFGDAGSQWRMTKLKGVYRQAEISGRPVDEVAIERYGDLREFDNAREEEIEIERRKVFGEDYIKKEKPSGDLFRQRKSYINSDKTSNLPIEQGKKSTPCDFPEQKLNYNLPIIDSTSLNRMKAQLIKAKLRKSADVAKLEEEYNKAMENHLQISSEPTVIELGPMECRLLAGTREEVVPVCNKRGRERGAVKENEDLTIEDMVREERKIRGQLGGDSLRAAERIVKDSKFQTDLDYMDENASNLAKRVHKSDISLKNIAINEYKKMNHILDHCQLCYHEDKKPSPVAPVISLATRVYLTLPTQPELSEGGAVIVPLEHRTNLLECDNDEWEEIRNFMKCLIRMYHDQGRSVIFYENAAAPQRRRHAAMNVVPIPYSLGKMAPAFFKEAILSSDEEWSQHRKLIDTAGRSREGLGKLAFHQSIAKEMPYFHAWFDINGGLGHIIEDSYKWPKGDLFTREVIGGMLNLETEVIRKQGRWHSNDKRVQSFRERWRKFDWTHALINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D4</accession>
    <name>A0A0B1P3D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002876">
        <property type="protein sequence ID" value="KHJ31456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D4"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="17696" checksum="22E25394E6064E91" modified="2015-03-04" version="1">MIEAMDITQETQAPSTDTSIELPPIPDIPLIPNSFPSTTSPTPPSNSQTPSYSTASRKILKPAVPTKRPIPENPPQNNKHSPDIANAFLPRELAEVVATRQRRERAWHVRLMMCTTIYSNIESTLSNFSNKIEKEEAAAFKAYLLLAIAKFAAVDSSPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3G4</accession>
    <name>A0A0B1P3G4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="7" type="ORF">EV44_g6299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002522">
        <property type="protein sequence ID" value="KHJ31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3G4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3G4"/>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="6">
        <location>
            <begin position="336"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1275" mass="143179" checksum="79D5226D67C8C3E4" modified="2015-03-04" version="1">MVGLEEIAHDPLPAAKCLEDMCQTTPKNDSSTIMNDEESEVENAERNIEMMFELTVHLPNYPKTVSVMVSNQEVIHDVHQLVTEQPGTFQYSCFHLEHKGKRVNDFTIISEIETLMNEPELTLIEDPYSEKEARIHFVRIRELIGAAGDRTDTLHGVSSGLTLYESVTPSETQGKQEVNSVQYFDEYDFKAAGSLSKLLPNVQESAPKTVKSLSLSPWHPPPYHLRQKGHLLYILLTTNEGEQYQITSCVSGFYVNKSSNMKFDPFPRISSKAYSAHSLLTLLGDISPSFLGCFEKLLEFNNSKELLATFQINNTIPANPWIVPSSNSSNVSHQPDITRTQESYLISGLENAETLRDWNEEFQSTRELPKENIQNRVFRERLISKLCADFTEAAARGAILVARGEITPLNPTEAKEAQIFVYNNIFFSFGADGVGTFAMEGGDEAARVATGKDVLGVRIVNQLDIKDLYTAGTVIVDYLGKRIVAQSIVPGIFKQRGPGENQIDYGAVDGRDVIAADERFSSVFEKLSKALKVKRHRVWDKNGKGFDLHGSIETKGLLGTDGRKYVLDLYRITPLDIEWVEEFDTVRFDPDKANNNNCKAYPHRITMLRPELIDSFCKYKMREWVDNEIKKRRQVSTNILNSNEIPVTKGLETPDANDPKTQIIPDLTPNKTDQINDLDKIDITGFSFSLNPDAFLGQEPQTEEERKQIIEDEKDVRDACKFLRSSVIPELLHDLREGDVGCPMDGQSLSRLLHKRGINIRYIGKIASLSDEKRLEPLKILSIQEMISRAFKHVSSRYLKNLPIPLSSSCISHLLNCFLGIELNPKPIPFIDEDMASLYRGLNLEFQIVTPQSLQQEIEISVMKRFQYVLKEGWISEIKKIQMLREVSLKLGLQLGARDFVFEPQPITNIPVSVNNHSTEPVKKPSASKKSKKLNSRSHSPAVLAPNSFNPDDIINIVPIIKDAAPRSTLAQEALEAGRISILQNQKKLGQELLLESLSLHEQIYGIIHPEVARVYNNLSMLYYQLEEKEAAVELARKAVVVSERTLGVDNPETLLSYLNLGLFSHAAGETVQALTYITHALDIWRIIYGNSHPDSITTLNNAAVMLQHLKYFHSSRLWFEASLDICSSIYGPNSINAATLLFQLAQALALDNDSKQAVIRMKSSYNIFLAALGPEDKNTREAECWLDSLTQNAVNIAKHAQAKNLQARRLRAAIQVGVGQATPGREKINPQVDKSSIDELLKFIEGKDARNKTKKRQPTGARKNPKSRVGNAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J4</accession>
    <name>A0A0B1P3J4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3J4"/>
    <dbReference type="HOGENOM" id="CLU_014574_5_0_1"/>
    <dbReference type="OMA" id="QQPFNAK"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="190"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="352"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="500"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="610" mass="68466" checksum="67D88F206142DFE9" modified="2015-03-04" version="1">MTGGKETPENIVSASPSSVRLPPDLSRPSHSLLRNQTVCFQNNLQSLSTTAVSSVNIQILAFPDGSRGTFSTAPTSPSSSIQGVSNAWNTSKNRHKFTNEGDDGFSLTSQPSSFRPDGDLMSLLDERLKHQSPEWTLLGTQRSNVHPFETVEVLNSSLQNFDKEFDEIDTINIEKGNEEEVILQWKTKYKHYLILSSAGKPIYSRHGDQNLINSYIGVIQTIISFYKSSNDSLFGFSVDETRFVISTYGPLYLVAISRLGESDSHLRAQLEALYMQILSTLTLPTLLQFFTNRPNIDLRRPLEGTEGLLSSLADTFTKGSPSALLSSLECLILQKPHRQLINISLLKTRSEKLLYGLIVAGGKLVSVIRPKRHSLHPSDLQLIFNMLFEADGVRAGGGENWIPICLPGFNNRGYLYMYVSFLGASEKQNKQSTHDTEARFPNEQIAFIFISAEKESFFDIKQMRDDTVDELEQNGSLELIKKAVCKGRPSILEISPGTQLSHFLYKSRSNVQFTMSDFTSNFNDLIARRRLMTLYHSLHASIHSKHSHLKILQCVSHETTSLAWCTPVFEFYCVAGSNLSREKLTKEANKIIQWVKSEEERLFIIGGAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W7</accession>
    <name>A0A0B1P3W7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001696">
        <property type="protein sequence ID" value="KHJ32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P3W7"/>
    <dbReference type="HOGENOM" id="CLU_973852_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31955" checksum="DD166EB1934D0165" modified="2015-03-04" version="1">MEQPKEFKILRKDFPVEIAGVPLSTKIASGKNADNTALISSLTNASKVRIPGLQINRIRWLQDGKEHEKARKKGHTRGSVILSLPTEELQWRVVRNGIVIDSILYSAQIWTPKAQTKQCFNCSQWGHVQAVCSKLVRCGECAGQHQSRDCPKDRILCCNCEQNHRSWQRAVCKTFKVYKEGVERARLENQIKTAEIRSEKIPATEAKYVPVNSSDEKGFTLVTRKSSETKRGPGRPRKDALAPMTSQIIATSPNAKVGIPPRSPRLSNVRANVENIVASTPAPFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Y6</accession>
    <name>A0A0B1P3Y6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002377">
        <property type="protein sequence ID" value="KHJ32055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Y6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Y6"/>
    <dbReference type="HOGENOM" id="CLU_1023761_0_0_1"/>
    <dbReference type="OrthoDB" id="3598506at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="272" mass="29968" checksum="6030B9520130DD19" modified="2015-03-04" version="1">MGSTPSKPISNSPSFKHMLKYFLTGNLSNGVRRTYPKHSSINNMNNNKYTENQTPIQMSSKENNAKSFENDKERYDYHTPQQEIDLLDVSLHKRLQNLGPVQRQDELTNNTFTIPSLSRNDDLLRTAKLPSSVPSQVVLNPSVSRLKSAKPSSPSPLSSVKKQIPDSATSPVLDSIRKTGLLDDSTAKTNNSAVALLMARNLFAKEAEVEFSKLGKSGYKGRRFLDLDTVGQILVMRDANEGLGDEEIERRLGLGNGIVKLLGKKGIIGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Z4</accession>
    <name>A0A0B1P3Z4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001678">
        <property type="protein sequence ID" value="KHJ33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Z4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Z4"/>
    <dbReference type="HOGENOM" id="CLU_2279527_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="102" mass="11458" checksum="7F73FECF03F3067B" modified="2015-03-04" version="1">MVVKAVNDTPGTDSLVPTPLVLGAYPRMTKLDPPAPDMVSRAKAVQKAMEEVTKLRLNRQIVQALREYNDPLIDAVRNLPVNAQVWVKPEKDGWTGPWTFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P410</accession>
    <name>A0A0B1P410_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P410"/>
    <dbReference type="STRING" id="52586.A0A0B1P410"/>
    <dbReference type="HOGENOM" id="CLU_2308160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="100" mass="11291" checksum="575F37AA750DE0DC" modified="2015-03-04" version="1">MSKRQSVKLPEKFLCRVCTKWKRKTQFSNKELGKFTFRNQNSATQVTPITAKLRCRGCTGEAAHELECLGPCAKTKLLNEFSKAARKSGGSNVFCELIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D4</accession>
    <name>A0A0B1P4D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative anaphase control protein cut9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002816">
        <property type="protein sequence ID" value="KHJ31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4D4"/>
    <dbReference type="HOGENOM" id="CLU_011751_4_1_1"/>
    <dbReference type="OMA" id="DPFHNNA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="565" mass="64435" checksum="3675BBA28E71D74B" modified="2015-03-04" version="1">MEKFLRDWRQDALNKHQYDSAVFIGDKLLALTQNDKDAFWLAQVHFSTGNYTRALSFLSREDLVSRNSSCQYLAAHCLIKQAKFDEALAILGDKNPVHLISIDNHIRRKLQHTNGYNKIENKSVLRLAKERREEASNEDAGNIRFEAAMCFLRGLCHAKRNAFDRAKECYKDAVRIDVQCFEAFEQLMKNCLMSPDEEWEFLASLDFDSITVSTDTFISQEAAEFTKTLYTTRLSKYKNPKAFKAAAETLSTHYNLSANPDLLLSQADLLFTQCRFKEALSITNSILQEDKYNFSIYPLHLACLYELIMKNELFLISHDLADNHPDEPCTWLAVGVYYLVTNKVSEARRYFSKASMMDPHFGPAWIGFAHTFAQEGEHDQAISAYSTAARLFMGTHLPQLFLGMQNHMLNNMTLADEFLKTAYGLCKTDPLLLNEMGIVFYHQDKLEEAVVMFSKALSIADEIESDSLAWVSTRSNLGHAYRRLYRLDEALVEFNQVLREGGRDAAVFCAKGLVLMDLRRPFEAINIFHEALAISPQDPIATELLNKVLEETVSSGIMDVNCDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E7</accession>
    <name>A0A0B1P4E7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002801">
        <property type="protein sequence ID" value="KHJ31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4E7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4E7"/>
    <dbReference type="HOGENOM" id="CLU_011017_4_0_1"/>
    <dbReference type="OMA" id="TFWAAFY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="812" mass="92549" checksum="6BD36EB8499F2B85" modified="2015-03-04" version="1">MSTTSELILPSSNHVTGFAKHEERMHQPEVQSSNTNQKALEKTISCVSCRKRKLKCDRIKPKCGTCVRLRHECEYPERRRNLGAKRARSSKEKEIEARLAQLETRLNSEGKCDIISPDAAAPRLERNWNMGIDLNLAIDGRPLLTSIETSPPISGFSQMPKETTSNINKELLSLGLQEPLPPDYMIKELYHIYFTLYHPSMPIIHQARFYMSLERPIQTRPPICLCYAMWTLATTLSPKYADYEDIFYERARRYLERAEMKGHGESFVSLYFAQAWGLVCNYEARKMYFSRSWMSTGRMVRLVQMLGLWRLDYDEADAKDYLPPPKDWVELEERRRTFWAAFYSDRFASSGSGWPMIIQEHEVFTNLPSSEEAFESGIPEKTVSLVEAFSLEGVSRISVYAGVLLTSAFFGQFFQHVRGTGPSHHPEDYQNGEFWKRHRKMENCLNNTFIYLPEALRLPAGRRDMNVIFLHMNIQASIIGLHRTAVMTATRYNVEPIVVRQSRARTFIAAEEIVSIINQTEREDALRMVPWVGFCLHVAAGIFLDDLKSDTPNFNSYPNLEQILAAMRQLSVHHSITKGFLTQCELDIASMSKNRFGREIEEDSSILAESQGVPITVADMQALLLQPPEKAKKPASVNKERLELGNTSNASLSPQPPLTQALKDCSPLSEDVLLGETPEYHPWEQHIDVQIPRFDDMSYAKFTPIAQSLDTNGYVDYNHTSPITPCHMESNPISPQGLSPFEHDSPLKYVKDTNCVPIQNNVIIDDFNATNDWIVPDPFEAIDQSCYVLPGGSDWNQSKFPTACPTRGSRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4H9</accession>
    <name>A0A0B1P4H9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002582">
        <property type="protein sequence ID" value="KHJ31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4H9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4H9"/>
    <dbReference type="HOGENOM" id="CLU_897705_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34474" checksum="AEFE15428AFF71B2" modified="2015-03-04" version="1">MVKRYHHVPLRRAFEIIAEEIPGLIKDYILQMAVKAVNDTVGSDGLTPTLLVIGTYHCMAMLDAPHPTMIERSRIAQKAMTEVAKIHARNNVSNALRQRNGTIIEETLDTTTSKEIESLKLSHVLRSQGLIRSPNGTFIDSRAKEVQGLLDTCVFKIINIKDVPLNARILGSRFVDDIKGKDTDRSYEKSRLVIQAHSDRGKKKLLTQSPTIQSIKDENILQVLLPLYGPAKSKSSPSRGAGVNAQYALHVWDSQEDSLNPSLQDPHSSPRVSIVFVPTSLSPLHLFKRSPPRLAQGVQSEGLYTFTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4M7</accession>
    <name>A0A0B1P4M7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002216">
        <property type="protein sequence ID" value="KHJ32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4M7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4M7"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_12_1"/>
    <dbReference type="OMA" id="AVTWRIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="341"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="408" mass="46833" checksum="FF4344DACF64D319" modified="2015-03-04" version="1">MAKDIRRFVENCDGCARNKAWRNRRQGFLKPLPIPDRIWTEISMDFITELPISEGCTNMIVVTDRLSKGVVADGLKSIDAESVAKWFIKRYLPYHFLPSAIVSDRGTQFTSAFWKRICDLLRIKRRLSTAFSPETDGSTERANEVIETMLRQYVNWNQSDWLTWLPIVVSSICGRNSASTGTNAFFMSHGWNQNLCEHMLDEVIEDNKRNSPIAKADRVVNKIKQVSEWAQASIAVAQESQEQNTNKYRQQAISYKVGDKVWLNLENIKTDRQCKKLDARFAKFTVTEVVGSHSFRLDTPPGVHNVFHSRLLRPANSSPLPGQIVDDNQPDSIVVDGSEEYEVDQILDQKKAPGKGRHMKYLVKWVGYAKPTWEPESFLQNTSALQLWKGLSRIDKINIKKQRKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P6</accession>
    <name>A0A0B1P4P6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001293">
        <property type="protein sequence ID" value="KHJ33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P6"/>
    <dbReference type="HOGENOM" id="CLU_906719_0_0_1"/>
    <dbReference type="OMA" id="DADITEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="41920" checksum="B64972EF30387870" modified="2015-03-04" version="1">MSDPTNEAENIATKTAAAAKAMNVLIESKIAEYIKYKFKDDNLWEAFKDDFCNCTAEDFKLAKLPLQRALRSHLRTFGVWVKWDRNTTIAKSLYNVVIEENPTEWTLKEISSSNETFSSNKIAAIMNKKFKLQPPETKFDKNNDNSFTRPTDKLIPEQDLNQDPYSPDEKLSQKSSQGQGYGKELANLARMYDNEMKYRGEQDCFDFKLAIFLDHCERTDIPDHIRAKAYPTMLSGAALNHYYANIASNKQPRDFDVMCHTTQNYFEGAEYKRSRLARWDELSLGLVIKENAEKSTGECLQILISELRNLQMSLSKELRSDSFFHNKLINSCRKVAACSFACFKPSETLTGLINDLQSSIKTYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G3</accession>
    <name>A0A0B1P5G3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G3"/>
    <dbReference type="HOGENOM" id="CLU_057568_0_1_1"/>
    <dbReference type="OMA" id="CVGTPAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31547" checksum="E5DF66FBCAE754AB" modified="2015-03-04" version="1">MSKDDLLQEPIVEHTIPSTDSKDRVKNKEKKRKRNEIQSSTGLVKKLKTKRRTFENETKIDVETGLNNSFAEMDSQSLADYVAKRTKTYESDLSPIELEDKYISASFIVNTVSWQKPRSLENLPQFLEQYSEDVKKLWSASKKNGAPHSLVIACAGLRASEIARFIRRYPKKEAKVAKLFAKHIKIQESINFLKTNRTGIAVGTPQRIIDLIIDGTLRVDHLKRIIIDASHIDQKKRGILEIKETQVPLVKLLALKEIRERFVTEKDNIKLIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N4</accession>
    <name>A0A0B1P5N4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative glycoside hydrolase deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001108">
        <property type="protein sequence ID" value="KHJ34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N4"/>
    <dbReference type="SMR" id="A0A0B1P5N4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5N4"/>
    <dbReference type="HOGENOM" id="CLU_021264_11_3_1"/>
    <dbReference type="OMA" id="ENWYRSV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059371" evidence="8">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="9">
        <location>
            <begin position="141"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="39842" checksum="C8676CC5C2C76B5C" modified="2015-03-04" version="1">MKTTLWTIVTLIAIVNAHLDGTAGSPQLMGARKFFSEMKSRNTRVLPTSLASEAPTVIEKRQTSNGRCGPGLGSCTNCCSAEGYCGTGPEYCISPDCQYQYGPLCDANVKPKGASTENIPRPLVGPIPYGGAGIFDCVTPGTVAFTFDDGPYLYTNDVLDKFKRYNAKATFFITGNNFGKGQIDTTPAWSDVIKRMVAEGHQVASHTWTHQSLDKVDSRTFHNQIIYNEMAIRNILGFFPSYIRPPYSQCEEDNCGNKLRNLGYHVIYFDVDTEGYLNTDVTQIQKSKDIWDATINPGNPSTSNFLEIEHDIHYQVAYNLTDYILDSIYSKGYRSVTVGECLGDPAENWYRSGKIPFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X4</accession>
    <name>A0A0B1P5X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative g protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002359">
        <property type="protein sequence ID" value="KHJ32084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5X4"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="ANSHWFK"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180040">
        <property type="term" value="P:negative regulation of pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="40991" checksum="E13A85D60251E3C0" modified="2015-03-04" version="1">MLCFRSRPNNDDRRSREIDSLLRREEKAMKKVIKLLLLGAGESGKSTILKQMRLIYTKEGFTKQEKEEWRGIIFNNILDGLRITINAMQEFNFEFQNTATLQYLPVIKQACDIEPEDLNSMKHLAVFKSVWSDPGFQKAVNSGKFALHDNLQYFFSDLDRLFNKDFVPTNQDILQARLRTTGITETVFDLGTFKYRMFDVGGQRSERKKWIHCFENVNALIFLVAISGYDQCLAEDREGNQMQEALMLWESIANSHWFKKSALILFLNKIDLFRSKVAHSPITKYGFTDFRGDTKDASLTSKYFMDKFTSLSRSPSQEVYPHFTNATDTDLLKVTMASVQDMIIQKNLQRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Y6</accession>
    <name>A0A0B1P5Y6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002349">
        <property type="protein sequence ID" value="KHJ32094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Y6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Y6"/>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OMA" id="YLKRSYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="6">
        <location>
            <begin position="4"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="797" mass="90761" checksum="A30D2E76EFD984CD" modified="2015-03-04" version="1">MQAPMISVPLKATNEIDWIQPLKQYIRQTYGDDPERYAEECAALNRLRQDMRGAGKDSASGRDLLYRYYGQLELLDLRFPVDENHIKISFTWFDAFTQKPTSQFSLAYEKASIIFNISAVLSCHAAHQNRSEDAGLKMAYHSFQASAGMFTYINENFLHAPSTDLSRDTVKILTQIMLAQGQEVFLEKQIADGKKVGLLAKLASHAGYLYTQVLEGTQENVNKAVFEKVWLLTLQIKSIYMTSLSQYYQALADDDANSHGVAISRLQVAETAAKEANNIAHSFPRTMPAISNLASETAAIFVEITKRNLSNIREKLSELIKDNDYIYHQTVPPEVGLTIIPKLPAAKAIPVSELYAGQDIQRITGPDIFQKIVPISVTESASLYDEEKAKLIRAETERVETANSEMAASLDYLHLPGALHIIKNSFDHKLTADDEFKRWCQEISNYDIPPSTFDHLKSSKESISCVLDKLTQQLDLEESVCEKMRSKYEADWTQQPSSRLTITLRSDIRSYREALLDASASDIKLQTRFCQNEVDYDEMRSAGQMDEADILFQKALSHAHGDKIGNVLQIETSLLDEDFSQDELSISDQVARIEDILKKLNLIKRERTQVLKDLKEKVHNDDISQVLILNKKSLSNFENEIFQAELEKFKPHQSRLLSANHKQSSLMKELTSTLNTLLQDKRVKAEQKKYETLSRQRSSIKSKYRRLYQEFLEYEAGIRSAQEWYRGMKDTVDSLGKNVEAFVNNRRSEGAQLLTQIEQMRKNISSIQNMDFDRVRGMMETGNNPSASGAINKNFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Z8</accession>
    <name>A0A0B1P5Z8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001841">
        <property type="protein sequence ID" value="KHJ32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Z8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Z8"/>
    <dbReference type="HOGENOM" id="CLU_037460_1_2_1"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="36188" checksum="18191431B55103A0" modified="2015-03-04" version="1">MASLGVSEATIPTAIVCVGMAGSGKTTFMQRINAHLHAKKEPPYLINLDPAVRNVPFESNIDIRDSVDYKEVMKSYNLGPNGGILTSLNLFATKIDQIISLLEKRSTPNSENMETQKSLKHILIDTPGQIEVFVWSASGSILLDSLASSFSTVVAYIIDTPRTASTSTFMSNMLYACSILYKTKLPMILVFNKTDVKDAGFAIDWMTDFEAFQAALRQEEETGISGGINYGSGGGSGYMGSLLNSMSLMLEEFYNHLSVVEVSSMTGQGVEQFFEAVSIKAGEFDRDYKPELERRKKQRNDEKMAKREQDLAKLMNDMEVSIGTNTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P636</accession>
    <name>A0A0B1P636_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002121">
        <property type="protein sequence ID" value="KHJ32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P636"/>
    <dbReference type="STRING" id="52586.A0A0B1P636"/>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="448" mass="49450" checksum="F2FA7C03101AB1F7" modified="2015-03-04" version="1">MVRNIVILGGNSHPQLVHEISQNLGVPPCQRILTKFSVGESRLEIQDSVREKDVYIIQSGGGKVNDHFIDLCIMISACKTGSARRVTVVLPLFPYSRQPDLPYNKTGAPLSRAPTDLSRNDFTFESLPPTPGLDQPQSQSLQSGNGIEGLQTKLKVASLDQQQHSTNYDNGITPPRRAGSITSPKSCNDHGATNTWSSQNIGPHFTTHDYENQTMIKEKRHMFQAKPGYKQWVAQAGKLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLFGKSLLKKFIQQNIPSYQKAVIVSPDAGGAKRATSIADDLNMEFALIHKERRPTRITERQNATMMLVGDVTNRLAILVDDLADTSNTITRAAKLLKREGATQVYALLTHGIFSGDAIPRINASALDKVIVTSSVPQKAHQRQCPKLEVLEIGPLFAEAIRRMNHGESISSLFRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6I1</accession>
    <name>A0A0B1P6I1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001993">
        <property type="protein sequence ID" value="KHJ32561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6I1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6I1"/>
    <dbReference type="HOGENOM" id="CLU_1603972_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="166" mass="18912" checksum="32F75C5BE99E2FE8" modified="2015-03-04" version="1">MEQIFEESEGDITSISLETEKGKVYITNLYNPPPLSHRSKELKTLKYLPEILSKEGHHILVGDFNLHHPRWGGQRVVSHHTLAEDLIEILAHKDMELVLPEGTITWSNRGSQSTLDLIFIFKELEDSVTRCELAKELEASSDHIPITTQLTIKPNCNGWLAEVFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L0</accession>
    <name>A0A0B1P6L0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative developmental regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001681">
        <property type="protein sequence ID" value="KHJ32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L0"/>
    <dbReference type="HOGENOM" id="CLU_052060_0_1_1"/>
    <dbReference type="OMA" id="PEWIIAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="35035" checksum="C2BC9CD96DC3EA80" modified="2015-03-04" version="1">MPTYLLHGFRWTRMNIRIRIILNDLEDAASEWIMAPATSKSLLDNFYEKYDFLPQYRLPLSPSSQNDNTSSTSISEDKFSNNLNFPHRLRASKSQVSLRNPVGKQEIESLISSNENQVKKLDEVEHKPLPDGSAQTSYMKTSIHFNDWSPIKLVEEYDPREQFFCSQPYAYVADYLVKVDLSLALKEQMLKYETFRAEQCRVDKAEHNLGMPLQISEKEKISTLDSTKTVKEDWFERLRNELENESDIDWYIVYCGDQEREISAWTLGNSNDEVLSAKSPPKTPWSAALKILFKGKHSDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N5</accession>
    <name>A0A0B1P6N5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative wd40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002196">
        <property type="protein sequence ID" value="KHJ32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N5"/>
    <dbReference type="HOGENOM" id="CLU_007901_1_0_1"/>
    <dbReference type="OMA" id="PHAVRIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="607" mass="65958" checksum="1E2AD0B467F9CB6B" modified="2015-03-04" version="1">MRDFLSQPRVTRLSKKLLVGYEIPQYTHSVKVYPIPSPNGSSIILIGNENGVKIIWRGGRKFLQKCPITTNSHEVNGSGTMIVSLDSDDEVEVTPIAVCDNKPEFMENEDEFDPLNPYPGVVQTLDLTLGTGTLQLAVLSSSMLKSYDILIGNRIVFIGACADNSLRLITLPITPPPPSIKQRLKLQTPYGSASTGSGMWEEKIIYLNGHEKVSNGVSITIDINDGNPYYIIASFSYEFNGRLLLWYSSLESPILQSEPFHSICLASPARAISFNTSPSRPNYLLVAEAKGVCRIFEYSLPQSQASVLDSPSLKHGHWLLSIMTDFSTTKSKFSNAEVSQPGFGRKAIADAKWILDGSAILVLLEEGEWGIWDLEGLRMGMNMSNTQGLLHYNGIKGGSKSKFSISGFIDASKKTSGSRPPPITGSKFVPMTPGTRRVIDPFGSHALMPKKGQISVIEIPPPSSTYRTDEAILFRLGGTFAIIPSILKYWSAHSGNDQSGSIFGSGSFGQTIKLEEAGLQGEYCTATELIPIFMPKAEAVVPEIIVLGEHRFVVISSETGKASLKGEIAIAHNAASNLKGSGSDQLNATNLGTIEMAVEKMKKKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Q4</accession>
    <name>A0A0B1P6Q4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001658">
        <property type="protein sequence ID" value="KHJ33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Q4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Q4"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="62"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="312"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="591" mass="66310" checksum="744272D59B924C9C" modified="2015-03-04" version="1">MSDKLTRQECKKSCPVVRSGRLCIEVTPDAKIAFISENLCIGCGICPKKCPFGAINIINLPTNLESFVTHRYSANSFKLHRLPTPRPGQVLGLVGSNGIGKSTALKILSGKLKPNLGRYENPPDWQDVIKHFRGSELQNYFTKILEDDLKAIVKPQYVDRIPRAIRSTDKTVRSLIKGSSSMKNLDEVLDVLELNHIMDRDVSLLSGGELQRFAIGTVCVQQADVYMFDEPSSYLDVKQRLSAAKMIRSLLRPNDYVICVEHDLSVLDYLSDFICVLYGQPAVYGVVTLPASVREGINIFLDGTIPTENLRFREESLTFRIAEAADEFMADRSRLLDYPSMEKTLGGFHLKVEAGDFTDSEIVVMMGENGTGKTTFCKLLAGSLKPDGNQIVSGMKVSMKPQKITPKFEGTVRQLFFKKIKTAFLLPQFQTDVVKPLKLDEFIDQEVKTLSGGELQRVAIVLSLGLPADIYLIDEPSAYLDSEQRIIAARVIKRFIMHSKKTAFIVEHDFIMATYLADRVIVFDGEPGIRARANAPESLLSGCNKFLKNLDVTFRRDPSNFRPRINKLHSQLDQEQKLNGNYFFLEDVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W2</accession>
    <name>A0A0B1P6W2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001899">
        <property type="protein sequence ID" value="KHJ32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W2"/>
    <dbReference type="HOGENOM" id="CLU_016102_0_0_1"/>
    <dbReference type="OMA" id="DLSHMMA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="657" mass="73702" checksum="D1B7EB340704F41F" modified="2015-03-04" version="1">MPSLPSQKGTGKKGRDMRHSRSRNTTPTVVSSLLSSDGFTSFLELPLQPLRAIEDFSNFYGNSIPTSKELDALLDRLKNLVHVVEARGSVCDKGMRLLAQTRKDRLEEIETERREDESKERLKRDVADEEEGGRSKVSKIKKRKESSNSREKRPLSHGSHTLAAQDALDSNDKKLVRKMVHDRGSPSSSLSPPAPSTPITSDTLENQGEKEDEDYNSEEHQTSPALVVPHHQTFGDDPSTFPDPTVYEIPEVKEGMTREQLKEVYSVAYFPKTDLEDLIPGSPPDKDFSNAKPTNQVQANTFATYIEPYFRPFDDQDIAFLRERGDRITPFVIPRRGKRHYSEIWAEEDSNISTDASQFNREKLPLNEPLGSMDRMNDETAESDSISTGPILSRLLSALRPEHRKSNTEVSNGNSNGILNGDQYLESNGDSNDALAVSMEVNNHASATQMPESNTEAWKKASHPTLDYAQIDERIKLELRHIGFLPADSEPDYDAHYDDDVAARLRYLQAKLKQIAILNGARKARLQELVKEKMAHQEFNTILEDLDSQVQAAYLKRTRTLGKSKKAKRLGGTNGSSNMISNVSGSGMARPGIGDMTKTLMERRRKWIDTIGGVLDPEAKKLRRVKDPGSSIFGKEVMVDFVKKEEAAWDEGDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P728</accession>
    <name>A0A0B1P728_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative duf1941 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P728"/>
    <dbReference type="HOGENOM" id="CLU_028752_0_0_1"/>
    <dbReference type="OMA" id="CFAWLNS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="678" mass="76410" checksum="58862C11150D1654" modified="2015-03-04" version="1">MDNSLARGYIQFYAWPVALYDIAMDKLKPSISSQNVEQKVVEDSLAILEKIKLLFQTKDDTSRFAGFAILKTVLENEKVIKDSDRIRVLWETIPPKFLDRLLRAQLNENISKQDANSMNDIAISVLHVFVNLLPDNSMIEQRLVARVPSLVIALTNTPSERKVTILKILLAIVSHLEGSIEFLNVQNISPLISIVTQEPLVLNLFHFAWVNVASNGDRVEIVREGIDKLIPCLILQFKDTDEITLLNFIAELLPKLEPAVLSYQPKWLNPLVGIIRNLVVKKSTKEGRKAYTTLTASLLSIWTSSCANLLFENSSSKNLDLRPFSYVFVSLLLIDIRSTISTLLPELNNSSYLEISQRLSAAFDIISSFLGVLLQSLDTPNHSTLKLTPDLLLRLRKDIAETFSLTIEFMRDRWDASIAGAAGLHPSARSTPLGSRLGLTWESMSNHVSTDPLLFAATRALAIWIREDENENLRCESAGLMDMWIDLYERRSNDQDILDIRYSIALALEGVMSIYDGVESFLIQDGWKVFANDLNHIIRYTNDFHSSDWEFLITEATRGIQVVRILLIIVDHPNTGSVEEAWMSVVKSATGIKVGSEPLPFVITEFQIAMLQLSLALLTKAADGMTKRYVTSQEPLSGLIIQLEERLQKMPNKNEAVELAELLKDVSLELMNLRQYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7L7</accession>
    <name>A0A0B1P7L7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7L7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7L7"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="OMA" id="PNCINAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="308"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="591" mass="66552" checksum="48DD720DB50313DD" modified="2015-03-04" version="1">MDFSWPYHKKSLSHPSFQFFSPLSTWGTRPRVFTYVRRTNGLRASQTISDSSPDLLQICILNRVSPNISIWNVDNAPPNCINAGSGLQTLLNSSETHYFVGGDFNLNHPSWDSSSVHASPHAMDLLQWVSEKNLSLLNSTETPPHRYGGTLDLAFCTQVGATCTIRSDLHTTSDHETLISTIPLAGLYIGGFEGRLHYDSRDEKLFLTLLGTSQNIPHIFSSLDAEDEANDIFQSIQTALLVSAPEAIRTLEVPLGGTKTVKLQQLAEVFSATYQVSSTSPGEDELTAPIIRLAWNTLGKRITNLFDRCLHLGVHPKILKQAKVRIPPRLGRRDCSLPSYYRPVALLSCLGKGLERLLAHRMSYCASKYEILTQNQCGAIRQRSAVELKTVPICDISKALLDRKVARIVTVDVKGAFDCVLYNRLLHRLRTQGWPETLVKRVKSFFQERSAHIILDLTTLEPFPILCDSPQGSPISPILFLLYVEPFLRLSRGRFGYADDGCLLATARTLEDCECKLESKFNQTLQWGYENGVIFDSAKMELQYFHNKRKYTEPSLHTGTYVVNLKDQVRRACQRTRVVTDHVKRLSKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7P3</accession>
    <name>A0A0B1P7P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001697">
        <property type="protein sequence ID" value="KHJ32971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7P3"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14593" checksum="52BC24787103FF19" modified="2015-03-04" version="1">MNGGNYPLRAYLDNSGFALSPCSAEACEVILKAGNGFFLSGAKLETATNWVPVLIPTVPSFIRKEQGQVEVSSSMLSNEIERVCSMQPAYVKLYGQNKSDSPHRTWMAYFSKAPRCGFRVFDESGIARPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Q8</accession>
    <name>A0A0B1P7Q8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphorus acquisition-controlling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000970">
        <property type="protein sequence ID" value="KHJ34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Q8"/>
    <dbReference type="HOGENOM" id="CLU_015973_1_0_1"/>
    <dbReference type="OMA" id="EQDMAFT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="493"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="589" mass="65074" checksum="AD3AEC0B7452C44B" modified="2015-03-04" version="1">MSNFKEGLDTNTKLGNEIGGSGSFMQTIMPTMPAISTSGEFYIMSSGDDCGFFSNKAPSQADINFPYLLQEKYERKEIPSGKELTMPPTPNSANIHGKNTATYTQSDYQLLHPATDGIKLHGNDQEVGFTPLASPAVSPLEYQFNALGYSFADSYLSPLSSPALQAQNDFSPLYDQPSSWVTNSPVLNNECITFNEFPASRTHNFDDKISKMQSRNSFRVKKSPVVNQNRGMRGSNSFSQSLDGMDLSYLPNSNFKSNPYASLTLGETPDDCSNLSEKLPSLPPNLFLAHDSVNLSPDLNTEDSNYISCTFASDKPATPASLMKITQLSMHTPKLEPTKTHNQSSVNSREVFLKPLNSQEAKSQIESSLNTVSNIIESESLPMRLPIKKKSNTVSIRQSPKDEYPGTNAASLRKSQFGTRNHKSRNSTLNVISPALLPRLSPNLKPLINSGGKELENSASLILASKSNYQNILDGTYFPGITYSPELSANLTSKRTSHKIAEQGRRNRMNSALQEMASLLPYDQNKNRRCEKNKNGETVGSEKSIKGISQNMNSKARTVERAISYIRHLKSQLEIAIEKLEEIETNKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R2</accession>
    <name>A0A0B1P7R2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001480">
        <property type="protein sequence ID" value="KHJ33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7R2"/>
    <dbReference type="HOGENOM" id="CLU_152125_0_0_1"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9425" checksum="333560776CDC88A4" modified="2015-03-04" version="1">MFFVFGNLIYLSVLLVNAIAILSEDRFLARVGWSNAIVEPSFGAVGLGDASIKSKLINLMTSIRTLMRIPLIIINTVIIIYEIALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X6</accession>
    <name>A0A0B1P7X6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001836">
        <property type="protein sequence ID" value="KHJ32754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7X6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7X6"/>
    <dbReference type="HOGENOM" id="CLU_046315_1_0_1"/>
    <dbReference type="OMA" id="ESNCTIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="60230" checksum="F68C7BC880273D7F" modified="2015-03-04" version="1">MRLHYLQPNVRNKAPEMLFLSGLPNQCNLIYAFPILFPRYPITLLGTKGNVSFSTATILSAERNAPPARGTNTLRIAKKDVVRDKGKPPAVGERKNYRKRIVLSNSNALDVTLPALNKRTIYELVQKPFIEKNLDLKSRSAYKQNKKDERDQDIDLKTTHSKPRDLEQKLMASVVGLSNETTDSLRALKAFKITQSWELFKQPGILIREHSKILSDRLLQAQEQKTTVRMVIDGVKGSGKSMMLLHAMATALVNDWVVIHIPEAQDITNAVTDYAPIPNSNLFSQNTLIAELLDIIAKANSKVLKTMKVKEAHPAILASLESNCTIHRLCELGAREPEFAWPFFQNFWSEITREGNPPIMICLDGLSHILKYSLYLRPDLSYIHSQDLAIIRHFTDYLSGVKTVPNGGAFLAATNRSHAPVSQSLELAIKRSDDEAANRKLSQHDPYEKNYDSRSDKMLADVEIFKLGGLSKNETRGFLEYWAKSGLLRSRIDEKTVTEKWVLGGHGIAGEIQRELLVRPYASQSIQYARSTSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y0</accession>
    <name>A0A0B1P7Y0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinetochore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000928">
        <property type="protein sequence ID" value="KHJ34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y0"/>
    <dbReference type="HOGENOM" id="CLU_058478_0_0_1"/>
    <dbReference type="OMA" id="KQHNRIV"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="31095" checksum="F0CE8C237F0CAC2F" modified="2015-03-04" version="1">MDNPAPTLIELKAEFLRQQIHILSEPLRPTADFYATRRFRESPLEKKTIDKALNQLNKRLKRHNNLIYGRRAQRHVAEQVDRLSWDNASQNQYSSGANETWTEIGTDYCASVTIEKLTEEWPIDISDNKIEEKEQDRSRVLGSEAEAGSDDNQNNNLLNQRYTKLRSDLVELNTRRHVVQQRLEKLNSLRDILKFFDNPMDIQSNLVTRGGGLEQELERMCRLMLRVERVLSASGPIHSRIETDIDQNYQMDLDEHEEHKILELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P826</accession>
    <name>A0A0B1P826_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sh3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000887">
        <property type="protein sequence ID" value="KHJ34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P826"/>
    <dbReference type="HOGENOM" id="CLU_024803_1_0_1"/>
    <dbReference type="OMA" id="RGYYMGT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="516" mass="57056" checksum="D3167E7D89E4047E" modified="2015-03-04" version="1">MSPTVTSSSSSSSSYLDSPSLLPLMTSQINFPTPKRTLSSHSAKHSLSELSSSSAPVKSEPESNDCFDPPTTLPYTIVRDFAYSKSHPMHCGTMICSSQPSSGLATPLSQSPEFLSDPLDPWDNKFRWSSKSFGEELIDNERVSQLNFRDGPPWSEDEDLQSPVVVSSRYRKYKSSGSKNGGRRRSDKETAEKRNSVIGQTSYEHSGTFYISSSENDCKRFYVSQDDDQAGPKSDIITYSTDKARHFDRYDLSSRRDSHFAGTLPKRSYADVIRDFSGSETSSTGSSPGTTPREESRYSRDYQFTITSSDEEMHGQAVALFDFISENENELPLIEGQVIWVSYRYGQGWLVAEDPKSRESGLVPESYVRLLRDIHGDLNSNTGHVNDLLNSFDDSGTQSSSEFGQISGKFSNSYDYHAPIVSMFSTSSKDLNPYPHYLLATYAGQAPPQIIHYQGQRGGSQVNTPTNLISSDNTLSPSNDGSLCSTPIATLLPMTNMDSTNSAEQDVDSNSRPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P845</accession>
    <name>A0A0B1P845_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000643">
        <property type="protein sequence ID" value="KHJ34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P845"/>
    <dbReference type="STRING" id="52586.A0A0B1P845"/>
    <dbReference type="HOGENOM" id="CLU_169175_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="103" mass="11112" checksum="D93A805763FDE061" modified="2015-03-04" version="1">MLFKTLLAFFSIIQVIAVHGAIIKGVGDEGGNLPAFRISSLSRKLLRFSYILSISMTIADIYCEDDASSRDGGQRNPSQTDKRKARSVNVDVCGKTSGDGPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H4</accession>
    <name>A0A0B1P8H4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001701">
        <property type="protein sequence ID" value="KHJ32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H4"/>
    <dbReference type="HOGENOM" id="CLU_033089_0_0_1"/>
    <dbReference type="OMA" id="AVRMPQK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="543" mass="61622" checksum="8E1F64E70B465A51" modified="2015-03-04" version="1">METSDSNALPEERAKILRADLKNWEKEFSSRNNGRKASRTDIKQNLEIAAKYKEYNRLRDALAHHAPHTSQIKLPQSKVNGRKKDSPKIEYNYKEKFLTPQKRKISTEGIGQIDSPSVAKCLFTPRKVSVGPTPQKEGQVLGLFDLLSDSESNVFRNIQKDVDPRNSNVITINNQKTPPRSQEKKDQTALDKNLTPASSSKRRRLDAFSTPSKNSRSEIYQGVTPLSVSKLNFSTPLFLRRENSTTRQPLDVEDFENYSFSPQKIRCMKRKPPIRGLSSFLADLRESQDENLDQELELLREIEADEINMIRRKPVASATALEPTPKDAESLADHPKISFSQAGDNDSPFCNKSAMLVKSNIKDQPVSQNMVDDQPSVVYKKKGQKRTTRLVKMRPTRSKPPSTMMNTDGSVDYNHRIHQGNSGLVIPFQNISATPTLDSEHQARNFNSDSQSEYTASEGETRYYRPNQRKESSKVHTSSTRVVCSNKESIDDREKEQLERASTHKVSALSLQNFRRLKLRNSGSKGPSATARNGRNKKFAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8J4</accession>
    <name>A0A0B1P8J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative shwachman-bodian-diamond syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8J4"/>
    <dbReference type="HOGENOM" id="CLU_137480_1_0_1"/>
    <dbReference type="OMA" id="HYKGKDD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="112" mass="12471" checksum="2C60B11264AC466C" modified="2015-03-04" version="1">MVRGDQIKVHYKGKDDDFIIFIDDIKLANSWKTDKSISLAHFVSAFKIFVTHKHGAQGSLDTASKATLENEFGTSVIEDVIKIIIEKGTMQESEAAERYGSKNDTKGSRIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T8</accession>
    <name>A0A0B1P8T8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000517">
        <property type="protein sequence ID" value="KHJ35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T8"/>
    <dbReference type="HOGENOM" id="CLU_842491_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="36130" checksum="A2A31462028D61E8" modified="2015-03-04" version="1">MQVAMIQSMLPYVAWPVRVSLEMDEDFTSARRTIKQNSLGWAGTVGVILTILLKHNALGSPLSNLARLAVTPGESSLQFSRKLRKLIFALPSDVLLREQAREVIQQHVRQFLPRTWTYIQQHTSSLPNDELADRIVQITEETGRWFLEDKLYQPVTPSHFPHQTISSIDSPSTSHHNPLQNEIFTTHQNNSDSQDEQAFISKSVTCYKCGKQGHYANNCKLYDSHSSKPPHNSYPKTKRFSNKLRDRYVALKKRGFGKNQTYKPNQQSRKEVSFVSAQYNDDVNSKSTVDQLDNDEIDDEIESFLEECLIDENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Y8</accession>
    <name>A0A0B1P8Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative kelch-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000493">
        <property type="protein sequence ID" value="KHJ35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P8Y8"/>
    <dbReference type="HOGENOM" id="CLU_002697_1_0_1"/>
    <dbReference type="OMA" id="CIGYIPA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="843"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1063"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1460" mass="160893" checksum="70DF1201A0DF1C7B" modified="2015-03-04" version="1">MAFLFKSKKNADKIQFTKDGPRAAVISPSTQQSTNSRSNEKSGGFSTTPGTSVNNSITSLQGGVQQGQPSPDQVNIRRGLPSEQAQEFSLRNGNTPVAQPMASSPNPSLYPWSQVRITFSTGPPGPFPRYGAAVNSVASKDGGIYLMGGLVNGSSVKGDLWMVEAVGNMACYPLTTTAEGPSPRVGHASLLVGNAFIVYGGDTKMDDSDVLDETLYLLNTSTRQWSRAIPAGPRPAGRYGHSLNILGSKIYVFGGQVEGYFMNDLVAFDLNLLQVPTNRWEILIKNSEDGGPPVGQIPSARTNHSVVTYNEKLYLFGGTNGLQWYNDVWCYDPIPNSWTLLDCIGYIPVPREGHAAAIVDDVMYVFGGRADDGSDLGDLAAFRITSRRWYTFQNMGQSPSARSGHCMTAHGKQIVVIGGEPNTLPREIGDLAIAYLLDTSKIRYPNDHNTQQLPDRVIGGRRPSVTDKPNLATSRGLASRDAPIIDTKRANGIIGRGNGQLSLSGNELNGAVSSPGLQAQVSQGKSGSSKLPRAAGIQGSSGNSTLEQAPPPRSNSATPTASGRSKYHARYEVGHSSSVDISGRSLDENLSTSSSRGLLMSPVSKDISKESPSSNERINTVSQSLSATKPTTNGNAPPVSLKNAGSGSSRSSSRNRFNHRQGSSDTTSDHASFRNASGTRPTSPPPSNRQVNNPLVRRGSARNSQTVSILKELDAAKNRNVWYASELALARKAGYTPSSSSSFDQQTLDSFDDEDRSLIEALIAMKTEIVNVQGSIDQQTILAARKIAEVEKQRDSAIKEAVYAKAKLASCNINQAITPSPDGESQDLDKISNSRSEDLTKRLASVLADQAELQKKNESLNSELEAEKRTRKLAEEVASSSQIRISELETYKQHNSVEIERLKSEFHELQVSSRKESIECAQALSSAQILQVEKEELQVKYQNVLSSSQINQETFQSLRNAIDSSVEMRYVLQRQLDDERGQREIVEAKLSRLRTEHEDCTSELEITTRKLREVEELLEAHSKEAKSNWQSIKSGLELMMSRENESSADTTNDQKTVALQSQIEAANNMVRKYQIAADSASEKLRSAEERIAGLEAYQEQASREGMSIRKQLQTTIKEIQTLQALNTDLKYQIENQQLETNAVNVQHNTLKDILEERGIRTSSSSRARGHSSPQSVSDTPDVNQVRELEQQLSASIASHEETKSIYEAREQEVERAYREKLSQLDKDYQTAVNYVKGTEKMLKRLNDELARFKVDNIRLKDQVTEAEKRAIAINGPIGWEEERAELQWRNESLQEEIKNSVKQLEQKISEVRKELISTEQERDGLKHDQEETQRRAQSEVAQLQKENTLLQQRVKDAEQKVSLLLDQVEQSVDIYRRHSRPVDLNGAAPSANSNSIYQRSLLTTDSASETSFDGGNRNSMALDSLASELETLRSNWQITNKNYRLSNAFDIEDITTTMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P914</accession>
    <name>A0A0B1P914_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcriptional repressor rco-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001427">
        <property type="protein sequence ID" value="KHJ33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P914"/>
    <dbReference type="STRING" id="52586.A0A0B1P914"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OMA" id="LTPDANW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="527"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="608" mass="65785" checksum="0716AD501FD7ED6D" modified="2015-03-04" version="1">MYNPHRGLGPPTGAANARLNELLEGIKAEFETQARTSGEYEHSMAQQIQEMHAVREKVYAMEQTHLALKQKYDEELSRLHRELEARGGNPRPSAIAVTSQNQGPSQQAPPSLGHGPSNLFSGIMAGQVAPGLVPPSQADQHLPPQHHMPQPPPGPPNLQGPPPGPSNLQGPPPPPPPQAQFQGAYSQGPAPNGYSQPPTSTNSPGPGKGRTLNRVQGGPATPQLNQPIPYSDSRAVASPQVGHPASQHQPLYRAGVGNSLADLELERLPAHQKKIEQDWFAVFNPEVPRVLDVELVHTLQHESVVCCVRFSFDGKYVATGCNRSAQIYDIVTGQKICVLQDETVETVGDLYIRSVCFSPDGRYLATGAEDKLIRVWDIASRSIRNTFSGHEQDIYSLDFARDGRTIASGSGDRTVRLWDIETGHNILTLSIEDGVTTVAISPDTKFVAAGSLDKSVRVWDTNSGYLVERLEGPDGHKDSVYSVAFSPNGKDLVSGSLDKTIKMWELVAPRGGHPNNVPKGGRCIKTFEGHKDFVLSVALTPDGNWMLSGSKDRGVQFWDPRSGITQLMLQGHKNSVISVAPSPSGGSFATGSGDMRARIWSFKPYQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B5</accession>
    <name>A0A0B1P9B5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9B5"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="ILMRGTF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="80"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="611" mass="66453" checksum="B4CB443C04932F4A" modified="2015-03-04" version="1">MQFSSHALFLLMDKLMDLEAWSLSDIKVIVAICALTLSCLFFITRYKNQKTSEDVILFEIPVPTPCPESKILEAPSIKAEGSTAIQCYAPATGLFLGFVNPQSPDSIDRAISRAQEAQKIWSKTNFSERKKVLRCIQAYIIKYQKEICKVACIDSGKTMIDATLGEILVTVEKLNWTCLHGEKALIPSKRPTNFLMAYKRNYVRYEPLGVVAALVSWNYPFHNLIGPIISAIFTGNGIIVKVSEHTAWSATYFTRIVKEALQVCGHNPQLVQTVVAWPQTANYLTSHPGISHITFIGSRPVAKLVAASAANSLTPVVAELGGKDAAIVLDSAKSDLNRITKILLRGCFQAAGQNCIGIERIIACPQVYDLLIEALAPCIKSIRVGSALDSSSGEEIDMGAMISDACFDKLESLIQTAVKGGARLLVGGSRFKHPVHVNGHYFEPTLLVDVTSDMEIANEECFGPICVLMRAKDAVEACELANKPNFGLGASVFGTRDANIEYIIQNIKSGMVAVNDFAAYYAVQLPFGGVGGSGYGRFAGEEGLRGLCNIKAICDDAWDCLGIRTAIPKQIQYPVPDTSKGYEFTKGVVELGYGTSFIDRINGVCSILKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C4</accession>
    <name>A0A0B1P9C4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001546">
        <property type="protein sequence ID" value="KHJ33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C4"/>
    <dbReference type="HOGENOM" id="CLU_113435_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="164" mass="18947" checksum="5F759FDA911CF403" modified="2015-03-04" version="1">MSESGPSLKRTHSSSSDLERNVVFELLVELKDRYMRDLNRLKENTERLNKVWIAAVEKNMPEAKCSQHFDLLKTAELGYENKISKLMDVTQQISKLRTEGLSAKKAKIQTTVLFSMVELSHHQTMGINIDIYGREFELPGEKQKLKPSKWLLETLGIRRNTGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9L0</accession>
    <name>A0A0B1P9L0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative heat shock protein 70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9L0"/>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="OMA" id="SRTPMIQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079848" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="803"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="919"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111614" checksum="63EA52F525D38485" modified="2015-03-04" version="1">MFYNPSLAILCLIYSFNFLSLAASAVIGIDLGTEYIKATIVKPGIPLDIVLTKDSRRKELSAIAFKPEKNLKSGKFPERVYGSDAMALASRFPGDVYPNLKVLLGHGTENSIVKEYALRHPKLKVETQNVKGTAAFKSEAFLAEEISWTVEEILAMELQNVQKNAQALAGKGSSIKDCVITIPPFYTIEEKRAILLAANLAGLHVLELISDGLAVGINYATTRTFSNINNGGKAETHLIFDMGAGSTKASVLKFQGRTVKDIGRFNKTIQEIKVLGNGWDRTLGGNLFNSLIVNDMVTQFMTSPAAKKKSINAHALKNDGKVMAKLEKEAEKSRQILSANANTQTFFEGLYEDIDFKYKITRVEFEKMAEAHVGRISQAIQKALDAAGLRIKDLDSVILHGGASRTPFVQRELERFIGDVNKLKTNVNSDESAVFGAGFRGATLSPSFRVKEIRVYDCMNYPSGVKWTNVHGKIQHQGLWKAASYFGDEKRYEFKNQDDPFALTFYQRIPLTENLSSGTSDHETLIVTTQNLTNSVTYLKEKHGCLPVDITVRLSAQILADSGEVLISKLVAGCEVEASEKESMVDSVKGLFGFGKKDQLPISDGEISESATTTPKTSEITSTLTTESVSSPSKDATQKSTKTRKVTEIIHLNYMTEIKGRPQLPASEISRMKERLAAFSSSDNLRRLRDEALNQLESFTYKVRDLLDEPDFIAASTEQERTTIESKSKDTSDWIYSGGTEASREEFRERLQDLQEAISPIEFRKTETVNRPAKILSMQSALKETKQLILTITEQIANDTKEHTVTDLTSQSLKPTESPSVEELVSPEEQKKKSTTTPTPQSASEPPAYTEADLITLQRLFDEYSSWLEEKLVNQEKLKVNENPVLICNDLEEKTKSLQEANIRLLVKNMQRLSKVRNSMTKTKYKSHESTDEAEKSIEAESSSKTTDIPRATFTFGDESVPSEAEMQEHLRKLESHKEGKVSESDKKKKQKKESNSKHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9L5</accession>
    <name>A0A0B1P9L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative powdery mildew-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001504">
        <property type="protein sequence ID" value="KHJ33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P9L5"/>
    <dbReference type="HOGENOM" id="CLU_247049_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1299" mass="147261" checksum="89278C4EA56C1053" modified="2015-03-04" version="1">MRRWIGALCYELHRGQLENYDCSNIDPDCNRQQFGRLIVEEPDKLVKIICAEIVKDLCNKGARAEDLFPLDYDKLVYSNFLLAIQEEKSWYHSFQRYLHNISMKIDGYQEQVDKLLSLTSIVLNPYYSFNCGDQINYMALNDQLITILVPPTATRITQFIEISLVSISKLRNIIEKEKFMPISTTYEIQFKEGPGNPILFNGKPVHLINTRLQLSAQDGKILEDYLVGLLPVIDVEVNADLDRIPESQELPVSYLNTNCSSCEILIRKGKHFFKTRSLLTNHKVTEYQGFWANKFLDQNNRSLNIETTDEIKNSLSPRSKTQENLVNFIDRNQMMVNSNATHEATKPKAKQPLVTSRRSIGDFQGCRSNNKSRILKKTSEVRNILDFNGQDKVSTNIRASDSLTALPTPASNVKPQLNISEGISLPIIIKEKILPSETGIINHRQAAVTHNDLSLSKKTQKNNCVMFKKIKKTGKQKSSPNKTKNNMKSKSGQILAGKKQKLEIKSVRISAEPSPSLRISFPSGQKLGTTTTGNGNKNKSIKEHIIQLPNSASDRNILQRDATTLGFVAEQPFHDQEIFDYYSASSKASIQIPKESISKEGELLITKENSNFQEELSPLLKYDMTLVKGINSMMDEINNHSLSPRKRCLHTGTPQIPELQSTISKCKGKPELKSQDTNNSLGLVLSTENIQMESLIPKATIKEFPLTVLAQKQISEDDIAQLSDTIDFSPNMISSREKNCKALDSKSKSIRSKYSNNFTTPEPQNESFTTQIPKFVFLDSNKKRSSSYEDKVPRKKYKHNLRADPGLTKNDFSGISNSRIRQTKDLTQIEYNKTTKVLSCNSFRLTEKQNKNLVSPNYYLEQDTPNTEFTRKPKLISFEPIQVNNQGNLCQSNHTLGQPKEIKRSFHKNKNKNLLEKPLNKTTLAEICKDSHNTSTGTSINNSNNVINDFSLQDPSTPVTIDNLIINTSSAFKKLKPGEDISKHILKISTPSTYHRTDITSSYKGLKVTDEGSPISKKDILNIYERSPETKIGQFRNKKKEQNIAFADRKIPDSFKSRIPLAKKLRAEPLLPKTSKSNIALYETIDDIDFTDIGSREVISQKMMHDPFSTQDSKLQRQNPFLKLLQGTITNNSNPIGSRSDQASINKPTKSSHPSTFKISDKNESPDGSSAKIKQRNDTWNEAIRTRYEGLYDSIHGIADDLITRLVKEEDRMRLLIDQYSRNSSKIINYLSTYRGEEQALILKRLENAKANILNNESKALKSLTKIHSNLQGHSIIDTVTVWEEKKSRIRAMINDNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9T5</accession>
    <name>A0A0B1P9T5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcription factor utp21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000574">
        <property type="protein sequence ID" value="KHJ35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9T5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9T5"/>
    <dbReference type="HOGENOM" id="CLU_002774_1_0_1"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="64"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="829"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113329" checksum="A12CF1E631C48FBE" modified="2015-03-04" version="1">MPDLVAEDKFDGPAPKRQKTCSAEVANASFQRSRLFTPFRTIGLVSSTCVPFTSTLLGKSNFQITTSVGNCLQTYSLKQGLQLTFLTRPQTPENITATFAWKDRVFAAWGGPNTAQGLWVFKRGKKVAEIDIPHDTNEAILQILIFGSWIVGSCSTRIEVWSSETLEHYTTLYPTKDAKGGHEISGGISNMPTYLNKIFVGRKDGCIEIWNVRSGKLIYTIPPPVPKCGAITAIQFTPALSLIAIAYSEGPLIIHNVKIDKTIIHLDGGSSVITSISFRTDNLGAGEDGRKPGVMATSGPSNGDVTFWDLNDGGRVMGVLRGAHYPPLKSDASIGGGLTKIQFLPSQPVLVSNGLDNSLKCWIFDESPFSPIPRILHSRNGHAAPASQLLFLPSDFDGADLGGKWLLSSGSDRSLWAWSLRRDGQSSELSQGNIRKKAKKIGILCSSLINEPSITLSDLKAPEIICISMSLNRDGGMGTSLVDGSVWQKVQNRKKHTDATSSSVTGWESIVTGHKDEKFARTWFWGRKKAGRWVLETGDGSNVKSVTISSCGTFAVIGSEKGHIDMFNLQSGLHRCSYPPKLKPAQAKNVLAKKIVLADEKNDTNTKQKHLLGLGKHKSAVTGLAVDSLNKTIISCSLDGKVKFWNFLTGCLMDEVGWPSVTAIKGLRFYPSSDLIAIACQDLCIRIIDIETKNTIRELWGCQGSINDWCFSNDGRWIIAASSDCVIRVWDLPTGNLIDGFRTKNQSTALAISSTGEFLATTSKGELGINIWNNKTIFTHVPTRNISESEIIEASCPVVSGEGGYQLLDAAFEDGGTISEFLAPVSSYDQLSKDLQTLSILPKSRWQNLLYLDVIKARNKPIEPPKVPEKAPFFLPSLERPLAQKKLDEEARESNTEKSRIIRLGHLTTEGEFTSTLRVGYETGNYVSFLNYLKTLSPSVADLEIRSLNPQEEFVPFITALTHQLHARLDYELIQTWMSVFLRLHSDLITHDHKIIEALKIWREEQAREGQRIGELLSYCSGVVGFLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Y4</accession>
    <name>A0A0B1P9Y4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000553">
        <property type="protein sequence ID" value="KHJ35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Y4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Y4"/>
    <dbReference type="HOGENOM" id="CLU_007446_0_0_1"/>
    <dbReference type="OMA" id="KEPRWLH"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="937" mass="105364" checksum="8B29ACCD96E90445" modified="2015-03-04" version="1">MNASESSDSSRSTLSPSSFTTPPGEDLSGKRGRPSKWTKSRQRKLARLYLYSTLPPKDISQALEEKDSNWKPGKESTVKTVNSLLDKQPRWLRPKNREDMTEKISELTKTKKQLPSHRALSKGPGNDPQLISEAYLPPGFSETPLEDLFSLDSLESHYPPSPLASGSTATGHTETAPTLYSLPFDLPFLEDSILPYKNHSNSNVKRERSGSYQQYGYQDIARGARGIKYHTFYQCPICGQTNSHSDSYLDQMKCAFIHNRDRISPDKDGMTPAHALALYQRTNNDTELTPETPAQTAELYKVLFPQDDETFRRALCILDPSGNTLIHNIRTRKLDNVLQYFEELTTDSSEPIFVKKTSEDDEKTLSTYLSTSSLKKRLPQYSTRYLKGITRLIKTHSISESSDVSTTIPKNRYSLATFDTFKSEPPTLRSSGLVTPPKQKVELMLSDSFLSIDRHIQRQGLCIKGFKAHDAKTCLCHTLDGLKSKVWVSNVGIVDYRVADPPMSLQFLNLGFRDHFGNTVLHMLAARGASLDVIFEALERGVDGNATNTSGQTFLHVLRRQILRNFAEDSDTLMWILQKLNPYNVKVNICDVFGRSFFHLLAHQADRLERHSLMTLQMLNIVPSSSRDAFGYAPKVLQTVIKKNEATCGYETTLGNSNNWSPYNMSNEPREFRRPNSIIHNIPDNEIITPNDLSTNSPEQANGGTGSEYDSDLHDDNEMLVLRHARLLEIARSAFITPTIEDKDGRNGLQCLAEASLTLSIDNSQVSVKGYTNKRKADQPEPERVSSRLDLRHELVEKLISAGVSLNNYDRAGNTVLMAFVQHLKDGEDDKTLAKLFRYLIERGANIHWRNRHGETALHIAVKLGRKVATRILLETGSNVHARNSDELGVLGVGEKYYFKARNDPTLYASIMACMAQCIQYGAAAMPTLVQEWSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC0</accession>
    <name>A0A0B1PAC0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000975">
        <property type="protein sequence ID" value="KHJ34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC0"/>
    <dbReference type="HOGENOM" id="CLU_177979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="77" mass="8435" checksum="D2407A8814FE5593" modified="2015-03-04" version="1">MCGQNIKSSPPHGQSKEDRRIMIRLAPDHKARKFGTFELRQTIQKLVPDSSLISDVWNVPSGVAILAPTPAKAATIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAK7</accession>
    <name>A0A0B1PAK7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">EV44_g2790</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001104">
        <property type="protein sequence ID" value="KHJ34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAK7"/>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1693"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KHJ34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2091" mass="232935" checksum="7756B01EB837FFCA" modified="2015-03-04" version="1">MYGTSSGPQVGVSTPRTTSSVRPLTISHGPLEHTILFPTHLHYHATQIKDRFLSALPTATEELAQDDEPSSVAELIARYMGFVVREVENGEDDAQGSYEELLNLILSEFERVFLRGNEVHALVSTLPGIETKKLEIIRSYYTARLASGRSIKAHESVLLRAVSNQRAKIYSIFGGQGNTEDYFNELRELHTTYPEFLNSLIHASADLLQSLSRDQRADKLFSKGLDILGWLHHPETTPDVNYMISAPVSFPLIGLVQLAHYAVSCKVLGLQPGQFRESISGTTGHSQGIVISAVLSAADTWESFEKLSVSALSILFWIGSRSQHIYPRTSLAPSILQDSVNNGEGVPTPMLSIRDLSQKQVQVHVDATNQYLPEDRHISISLVNSAHNLIVTGPPISLYGLNLQLRKFKAPSGLDQTRIPFTERKVRFQNRFLPVTSPFHSKYLLGAIDNINSDLKDVIINSSELKIPVYNTNTGDDLRAEVTGNIVPTLINLIIKDQVNWEKATVFPGATHILDFGPGGVSGLGVLTSRNKDGTGVRVILVGTLEGTVPEVGYKAELFDRDEENAVKYAVDWVREHGPRLSRTSAGQTFVDTKMSRMLGLPPVMVAGMTPCTVVVEFVTATMNAGYHIELAGGGYYNAKTMTEAIRKIEKEIPAGRGISVNLIYVNPRAMQWQIPLIGKLRAEGVPIEGLTIGAGVPSLEVAQEYIETLGLKHISFKPGSIEAIQSVINIAKANPTFPVMLQWTGGRGGGHHSFEDFHQPILQMYGRIRRCENLILVAGSGFGGAKDTYPYFTGEWSAKYGYPPMPFDGCLFGSRVMTAKEARTSLNAKKAITEAEGLDDSDWEKTYKGPAGGVITVRSEMGEPIHKLATRGVRFWAEMDAKIFSLPKEKRVPELKKNRDYIIKKLNDDFQKVWFGRNKEGEAVDLEDMTYSEVVYRMVDLMFVKHENRWIDKSYERLVGDFIRRVEERFTHVPGHPSLLQSYSELDIPYPTIERILSSYPETATQLINAQDVQHFLLLCQRRGQKPPTFVPSLDENFEFFFKKDSLWQSEDLEAVIDQDVGRTCILQGPTAVKYSTIVNEPIKEILDGVHNGHIKALTNDKYGGRESTIPVLEYFGGEYQTDVGDIDIDGLIVSNQPHCTTIRLSSSSSTPLPDEDSWFSLLAGSKRSWRYALFTSKVFIQNKKFETNPIKRIFAPSRGLYVEINFPNEPSKTVINVSEQPRINQYVKVIEISFSGKNEITVNLIKETNALGKPISLPLKYTYHPEAGYAPIREVMSDRNNRIKEFYWRSWFGNEALNLNSPVTGKFFGGKVCITSEAIKDFVHAVGNTQEAFVDRPGKEIFAPMDFAIVVGWKAITKPIFPKDIDGDLLKLVHLSNGFRMLPGAEPLKMGDEVETTAQINAVINQDSGKMVEVCGTITRSGKPVMEVTSQFLYRGDYDDYINTFQRKNETPMQINLATTRDVAVLRSKEWFILDEPDHELLGQTLTFRLQSFVRFKNKTVFSSLKTTGQVLLELPTKKIIQVASVEFEAGVSHGNPVIDYLQRHGSSIEQPVNFENAIPLSGKTPLQIRAPASNETYARVSGDYNPIHVSRVFSNYAGLPGTITHGMYSSAAVRSLVETWAAENHIGRVRSFHASLTGMVLPNDEIEVKLQHVGMVAGRKIIKVEASNKVSEEKVLIAEAEVEQPVSAYVFTGQGSQEQGMGMELYATSAVAKEVWDRADKHFMDNYGFSITNIVKNNPKELTIHFGGPRGKAIRQNYMSMTFETVGSDGATKSEKIFKEINENTSSYTYMSPTGLLSATQFTQPALTLMEKASFEDMRSKGLVQRDSSFAGHSLGEYSALAALAEVMPIESLVSVVFYRGLTMQVAVERDETGRSNYSMCAVNPSRISKTFNEQALQYVVENIAESTGWLLEIVNYNVANMQYVCAGDLRALDTLAGVTNFLKAQRIDIQQLMQTLSIDDVKSRLMEIINECANQTKSKPQPVELQRGFATIPLKGIDVPFHSTFLRSGVKPFRSFLLKKINRTSIDPSKLIGKYIPNVTARPFDISKEYFEDVYRLTNSPKIGAILANWEKYEDGTPVSTGVNGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAM8</accession>
    <name>A0A0B1PAM8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000283">
        <property type="protein sequence ID" value="KHJ35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAM8"/>
    <dbReference type="HOGENOM" id="CLU_1846599_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15357" checksum="9E5C8CFE0F3537D3" modified="2015-03-04" version="1">MGYSSAKGSKKALILPDYKAESVLNTNAKQRAHQHDFQSLKSITVNPQPYRGKSSSQKHLDQRFFLRLSQEHGWRKLSPAGIRALLVQRLAISPTFIGKIKSVHSDFALSPCNKDAREALLKAEGGLFMPGAKLEPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY7</accession>
    <name>A0A0B1PAY7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY7"/>
    <dbReference type="HOGENOM" id="CLU_139267_0_0_1"/>
    <dbReference type="OMA" id="MNDSNCL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="15117" checksum="93F49A3B126B98A5" modified="2015-03-04" version="1">MEVVKPLYGMAEAGTHWWAIYLKHQQEKLRMETSTFDPCLLVTSRENINFGIVRMQIDDTIILADEGFSVQEEERLLEAEFLAKSKERLTVNTPLDFTGCTLTSMNDSNCLQLKQKGQGNKIELINVTDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB10</accession>
    <name>A0A0B1PB10_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000398">
        <property type="protein sequence ID" value="KHJ35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB10"/>
    <dbReference type="HOGENOM" id="CLU_2499558_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="86" mass="9768" checksum="910E81F8444ACFB6" modified="2015-03-04" version="1">MLGSSAITRFYRSSTASLRLKIFFPTPNLLKRTNIIASNLYADQLDDGLRAHQGLFKIRLSKKLRSLNCPSCLCRDLHHQSSRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB39</accession>
    <name>A0A0B1PB39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB39"/>
    <dbReference type="STRING" id="52586.A0A0B1PB39"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OMA" id="WGMGVMV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="632" mass="69311" checksum="BD6F539B936F4ECB" modified="2015-03-04" version="1">MTVVLETEGNAAIELYGNDTDEPEFKPGWRFFLIFLSLAIITLAASLDATSLSVALPIIASKLHGSAIEAFWAGTSFLLSSTVIMPSFGSFSHIFGRKPLLITAMISFLAGSIISAAANNFVVLLVGRSWQGIGAGGIISLTEIIITDLVPLQERGKWYGIVSAVWSVGSVTGPIIGGVFAQSVTWRWIFWINIPIIGVGFTCVVIFLKQRMTRQESLKVQLCRVDWLGTILFIGATTGLLIPITWGGVMYPWSSPRTLTPFIVGVLGLAIFGPYEYYISKEPMVRLSIFNRPTSCIVYFQAFLHGIVLWSLLYYGPFFFEGVRGYSPVISGVAMFPETFTIAPVAAFTGIVVSMTGKYRWALWGGWILTCVGFGLLYIEDARTPNVTWVSLNIIPGVGMGMLFTSMALAIPAACNPIDMAHAVSVYTFFRVFGNCVGVAISGAVFQNQIKHNLLAYPLLASLAEKYSEDAAALVEIIKVMENSPIKDQIIQAYADSLKTVWITMSAVSGLALFSNFWVKAYTLQKSLVTEQGFLHKKKPSDAEESLQSQLHTISGDQSFTNSNEPNSSHECGISEKKSIFSKSLLAKVTGEKKIDNAPKEEKPFRIVKIKDSKSKSHKFIIRNANHTEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB84</accession>
    <name>A0A0B1PB84_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB84"/>
    <dbReference type="STRING" id="52586.A0A0B1PB84"/>
    <dbReference type="HOGENOM" id="CLU_003016_7_4_1"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="115"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="694" mass="79971" checksum="AFF19594AD2FDBA2" modified="2015-03-04" version="1">MNQLPFRDINVHATLTQYAFTSPSSPSSQTLVVDRPSGNIRLNNETSLGKRIFSIAGILGIIKLRLDKYIIVVTRVEKAGILKGHSIYQVKATEVLPLRERTLYDQDEDTYLALLRNFLKLEPMYFSYTFDLTNTFQRQSQLDSSIPLWKRADDRFFWNKFVQTSLIDFRTSGNRQQPGQQPGVDPYILPVIYGMLRIVPTQIKSTPLTLVLITRKSRHMVGTRYFSRGIDEKGNASNFNETEQIVILNDSPSTLDGFGGEKNFKDRNIGDSRKELKILSYVQTRGSVPVFWTEVNNLFYTPKLQVRSVEAAVSAARAHFEEQVRLYGDIFLVNLVKHSGREQAIKDAYEKMVNLLTSKPVDVLGQDSFIDEKSRNVEPINYRQIMDHLHYIYFDYHTETKGLKLHKTQILLDRLAMVLEKQQYFYCVEVPGDKARLDVRNQQTNVFRTNCMDCLDRTNIVQSLLAKTVLNRQFRDLGVLNRHEDLTQFEDFEFLFRNLWADNADVVSKVYSGSGALKTDVTRIGKRTKAGMIQDLRNSIARYVTNNFLDGPRQDAFDLFMGKYLPGTDSDLIFIDKRPLLIQSIPYILAFSIFFVLIGLFSRRLPDAAAFPVKFFTFFWLVVGVWCSVFIMSHGMLYVNWPKLVPRPWAVEGYKEAFNNVLKDKVIGSLVTRHERGLSIARYTNAEEGKKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE9</accession>
    <name>A0A0B1PBE9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBE9"/>
    <dbReference type="STRING" id="52586.A0A0B1PBE9"/>
    <dbReference type="HOGENOM" id="CLU_906720_0_0_1"/>
    <dbReference type="OrthoDB" id="3591352at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="307" mass="36174" checksum="BB66FC2B167C3DD2" modified="2015-03-04" version="1">MDRLDQIRLVQNRVPEGSARCQELEFENYQEFITWLEIEKNQVVWNKHDTRGRRERPGVTRRATKIEWTERYRCPFSGKKRASRQSPNPHRKRKDSMKVGCTASIKAKKYIDSDRIKVVFDARHINHEPNSVSSWQRQRLPPVVKNWLKKVVTTGVNWETYKTVMKPDFEMLTALQSDGLASDLSVAVPQMLRVSNQQFNDYRRSHLKSIAQVDMNCEEDYERNELIYSGQTQKESQGPEGLHRFEELDKGAELKSQLLEVFNFILPLLDRYSQFSEVQRKLLDDATVSFQSFRRSFETLRPQSQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF0</accession>
    <name>A0A0B1PBF0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000761">
        <property type="protein sequence ID" value="KHJ34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF0"/>
    <dbReference type="HOGENOM" id="CLU_153395_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="16292" checksum="6EB4F8A19182D340" modified="2015-03-04" version="1">MVTQNKEASLARAKSLLEERYYSSLIAFWSSQAPKQYKDLEIRITSRIPPELSLLPRWSLGKLLAARSGHGDFASYHRRFYHKNADHNCSCRLEKSPEHPFSCQLTRRLRGRLRGHLKHNMNNFKLLYQCTNPSMICRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU7</accession>
    <name>A0A0B1PBU7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative rad55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000292">
        <property type="protein sequence ID" value="KHJ35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU7"/>
    <dbReference type="HOGENOM" id="CLU_043547_1_0_1"/>
    <dbReference type="OMA" id="IACNALR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="71"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="55152" checksum="71ADCDE76E5F5C63" modified="2015-03-04" version="1">MKKNTAVDSEDFRLGSDYAQLYVMYYNKREDKCMNYNSIHGSDLSNFPPSSTHRMPTISAAQALKDLKSSPTRCISTGIHELDMVLQNKNLSDEEFTFGGISRGQVTEIYGPPGVGKTALAMQLAASVLHSGEEVVWVDASHKISGARFAQILKNFKPLNAPSQLSTISIDSLLSRFTHFLTPTLAHLIALLSISAPSYLPKNTSLLVVDALSALTTVAFSRDIDTLSNFRKPGCGFCTTSIGILNTDWSLIVTKPFGSKFVILQKLISSLQKLAATRNISVLVTLQCATKINPGLDPILVPAINSSIWDQGFGCRLVLYRHWGWDFGTADYISGFRFAKVIKAEGTDFTDNAQNIVGLRVLETGLISYFQPYFDLQANNAVKTNEKETTISKPPKRKLSLVDMEIPNSDNEDENYGWRKEDENELPPPPPQWQGSEDLLIGIMVDQIEDEDGRERLLDLENEEITRDLIEIPINKRIPIKKKIVIENSDSDDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC84</accession>
    <name>A0A0B1PC84_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000232">
        <property type="protein sequence ID" value="KHJ35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC84"/>
    <dbReference type="STRING" id="52586.A0A0B1PC84"/>
    <dbReference type="HOGENOM" id="CLU_014853_3_0_1"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="11">
        <location>
            <begin position="184"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="803" mass="90351" checksum="3F1B6CE6CD57C121" modified="2015-03-04" version="1">MSPSPNGLHETASQVEPSAAPHSIYESSSVAEIRNSLSALFAREAAITPQIQTIVDSKTELSRELGRLDLLRANLSAQVIHLRDINNGKLEGAAETSRQLSSKIRELDLEKSRVEETLKVVEQVVELKTCVKGIVGSMGALQDWEAAANYISRASKIPNEIVNGEFASRIIPSAEVPETPRCAIENAKDSLCGLFLREFEKAVKEGDGNKITRFFKLFPLIKKEEIGLQVYGKYVCQGVATRARESLKDNVKNNDMLYYANILTRLFEHIAQIIEGHGVLVERHYGQRMMIKVIERLQLEADVQGGIILDAWGEKRNIERKLIDVKSYPFLFLLQSFLPSRKNLGVPRSSSPASGGGNNNSALENEGSVDLKEVDGILSEMAMMLGRWSLYLRFVASKLKDQNSNTEEPLMIPELLNKSTLMEKISTRLIASFNAMTTFFFRRSVEKAFQLDEPPSGLSLDVSKSLDCNPPFIISAVDDVMYIVSTVLQRSLTTSQIDVISSVVPTIGRVLGSDFIGMIQRKMRDESYPKPIIQGGLPPEEKVVAFIVLINSLEVANDYVNRIIISRLKPSDTTVQNNSIKEFFPFNDDFKIVTNMLENLNAAFASKVTELHSDGLHVMFNQVIKPRFRPTLTDAFRDTDYQLTEDELAEIAHEEGTDLSSIQELVINSFEHNWEAIMKPIQRIMNHKSFIQLLEQTADYFARILEKRIWSYAGKMNTYGAQRMEKDFSGIIRVVTKGNRYGVRSSFSRVSQICMLANMEEEEWEAINNLSELVDPDGGEVEDKMVWVLSENERQKARNLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE5</accession>
    <name>A0A0B1PCE5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000958">
        <property type="protein sequence ID" value="KHJ34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE5"/>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="OMA" id="HYYLLIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="412"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="578" mass="65872" checksum="BDDF91B9CCA9FC80" modified="2015-03-04" version="1">MGQVFLHLVAYPLYKGSTGITIGHMLLLRRALAGGPSLRISRIFLTRSLSTEPSVTRKSLEKTPIIQNEDKPPRLSNNLKPLTTSDLNLPSKILETAVTTLTTILILGIGFGIGGYAYHKSYKWLVLEKIDNAFKPGDPALDAAWITHEKNTSNNQPDAEDHWILRDEQEKINDIVNGKITGHYHLLIGEKGTGKSSMLLDAMRNVNSDGCSMLEAHADLEIFRVRLGKAIDFEFHEDYIGSYFSERGPRDSTPILDIERAFNKLEKVALRRKRRGNSPLVLIINSIHFLRDDHDGRDLIELLQQRAEKWAANNLVTMIFSSDEYWVYERFKQFATRMEVTAISDLPKSRAISALAKYRQKYFHQTPSNSILEEVFKRIGGRLIFLNRVARAEDMLQACNDIIETERRWFLNKAWILGAEMDDDVINEQKYASAAMVLAQALVKAEDESSKSLSEQDSLPEIPLHIARQIMTRSDFIRDFDHVNLFTITSTAMVRADSVPMQRAFRIICKNPDFDKHLEKTIQRISDIESLGRTREIVAKDLVLGSRYKISPIDPTVKNVNHWELTIEEKNPADINED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE7</accession>
    <name>A0A0B1PCE7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000063">
        <property type="protein sequence ID" value="KHJ36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE7"/>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OMA" id="GSMSMCA"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="387" mass="43726" checksum="92EB3CBEA20942D9" modified="2015-03-04" version="1">MTENSEKVFNFKDPDEKIGFLQALDSFFQYSKIAHHEITHVRRQSFYALPKQHFELLAAPPFLYQETLNSVDDAIDENSKLSLAIFQAGLQSFDIETSTPESWQGKATSNDIEKARSTLRQFFRDWSNEGTAEREASYGRVVEILQAEKSSRPNGKLRVLVPGAGLGRLAFELCRAGIDAEGNEISYHQLLASFYILNICPKAHEHTLFPWVHSFSNHKTRSNQLKSVKIPDLHPGTTLSSMKIVGNMSMSASDFLLLYGNEQQKESFDAVASVFFLDTARNVVRYIETIKNCLRIGGLLVNLGPLLWHFENTPLETSETEQDNHEDHGIAEPGAVELTDDEVVTLVEKFGFRIESRESAIAAPYIHDADSMLKNIYKASFWCARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCF4</accession>
    <name>A0A0B1PCF4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5782</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="JNVN01000058">
        <property type="protein sequence ID" value="KHJ36352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCF4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCF4"/>
    <dbReference type="HOGENOM" id="CLU_000995_3_1_1"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="470"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ36352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="954" mass="105738" checksum="CAA6D11452BCE2B1" modified="2015-03-04" version="1">MSNNFYSDTPTINGNGTHRGHRRSSSARPLGPPTDNNAPLSDDEGFADDQIPDNTKRPRRKDRPVPKVEDTIGQYVQINFEEFLESFVDEPSPSAASTPASEASDRYYVAQIHGLKTYNLSTLYIDFAHLSQYKGGALAEGIVEEYYRFLPFLIKGLHNMIAKYEPRYFREHRQPVSSSNQTSSASDSNAATATQSESQGILTSNQQTDKLFTLAFYDLPLITRVRHLRTANIGQLMSITGTVTRTSEVRPELLLATFTCEACRSTVPNVEQTFRYTEPTQCPNESCGNRQGWRLDIRQSIFADWQKVRVQENSAEIPTGSMPRTMDVILRGEVVDRAKAGERCIFTGTLIVVPDVSQLGLPGVRPQAVRDTQNRSADSNGVTGLKGLGVRDLTYRLAFLACMVLPDTTSTGSATRPGINGQSASILATISQGGPLDCTEEGEKAQEAILASMTHAEIEDLRRMVHSDHIYSRLVNSLAPMVYGHEIIKKGLLLQLMGGLSKKTPEGMALRGDINICIVGDPSTSKSQFLKYICSFLPRAVYTSGKASSAAGLTAAVVKDEETGEFTIEAGALMLADNGICAIDEFDKMDISDQVAIHEAMEQQTISIAKAGIQATLNSRTSILAAANPVGGRYNRKATLRANINMSAPIMSRFDLFFVILDECNESVDRHLAQHIVNIHQLRDEAVQPEFTTEQLQRYIRFARTFRPELTDEAKEVLVEKYKELRNDDAQGGIGRNSYRITVRQLESMIRLSEAIARANCVEEITPSMVIEAFNLLRQSIISVEKDDVEVDGDEDEENLLDNGLINEDRSSRMVEVSANRERSEHRDNASANEVNGVTRPEKPKTKITYDKYISIVNLIVQRVNEDEVKNGEGIGSEILIQWYLEQKEDELSGEEDYYAEMALAKKVIKRMVKENILMAIRGQGLVGDENGGNTANSDQVVYVLHPNCAIGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ1</accession>
    <name>A0A0B1PCJ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mfs general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000037">
        <property type="protein sequence ID" value="KHJ36397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ1"/>
    <dbReference type="HOGENOM" id="CLU_022040_1_0_1"/>
    <dbReference type="OMA" id="SGVEMWR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="460" mass="52149" checksum="D88EAFDA77E04236" modified="2015-03-04" version="1">MTAVETVTIINKSGKIVSTGKHLVNIFKDAKTAYNVRKNELNDQKYLDENHKQDHLEVRTLVSEHSQRTRRSNHSKRHRHRESNEYSRPPLTVRNLSYVTESHTLRKSGHNSDHRSYRSTSPNQIFTRPSDTKSRRHNRPIYRRHTDAPDDTNTTALVSTVPPPYTSRILRSRSNPDFSKDSKIDMNLAYGHLPFDCRSEGTQEIPPEFELKKMIGKLNKLLLEARCLQYSATAIIAHLQKDPEAMAAVALTLAELSTIVNKMGPSVLRTLQTASPAIFALLASPQFLIATGLAMGATVVMFGGFHVVKRLQTNTMDMHEEKKLESAMTYSGIDIESIKSWRRGVAESEGFKLSSLVDEHYITPDATRDCRGRIKNRYLTYHTEDCSVYSENRSKASNNKSTRVRSVSEKSPSEISSSSRRTSVTTSTSKSSQGLDKMKKKKKEKKKPSLFSTLFEMKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ7</accession>
    <name>A0A0B1PCJ7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PCJ7"/>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000266">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="413"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="505"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="599"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="783"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="879"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1172"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1261"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1342"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1391"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1364"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1741" mass="193842" checksum="C1DFB7FE7724A383" modified="2015-03-04" version="1">MTPEVSSNSKRKREREDQEEAAFPRGGGSILTPLEHKQIQIQATRDVLFEQQGKEPSENLGKTGDKINKRRKITPKAKNKGKKDVTIEADQDNPKIESLNFKRLGTGSLVLGQILEIYDSEIALTLPNNLTGYVPITSISDKLTEKLEIINATADDDESKEPSTDEIVLQKLFKRGQYLRAFVVSTSDDLNENIRKKKRIQLSLRPQDTNNGLDPQSIVVNSTLMGSIISVEDHGVILDLGLEDSSVRGFMSSKEIGNDIELLEMQEGALLFCIVTGVSSNGKIIKLSANKDRIGKYDKNFLSEAPSVDIFLPGTVVEALVTDISARGIVGKVMGMVDVTADLIHSGAVFSEKELQKIYKIGSKIKTRVICTFPQADFLKLGISTLDHILSLTNKLSSRNNDFEDPLAILPMSSIVEKITVKKVFPNIGLFVDVDIKGITGFVHISRISDKKIEGLSEKSGPYALGSVHRGRVTGFNSLDGLYNLSLQSSIIEQPFLRLEDIEVGTIVQGKVEKLVISSSGVNGVLVNLADGICGLVPQVHISDLKLLHPEQKFKEGTKVNARVLSTDYNKRQIRLTLKKSLVNSDARQFLNYRDIEPRMQSPGTIINIIPSGAVVQFYGNVRGFLPVAEMSETYIKDPSQHFHIGQVVNVFVLNIDPDLERMTVSCKNPSSLSLAQQAIFQKLEIGQVVSAKVIGKTNEEIQLTTEQDGLQAVLSVEHLSDGSASKNLSLMKKVKVGGIMTDLAVIEKLSKQRLVILTKKPSLVKDSKDCVLIKSFDDIKLNTMVNGFVKNITQTSVFVQFGAGVTGFLSKSKLSDDCIALPDFGMRRHQSLRAKVVKMDQSNRQFQLSMKEVNTESSDRQGDITLTNPVDENIKFLSDIVVGLCTKARITSVKDTQLNVQLADNVKGRIDFSQIFDSWDSIKDHKRPLKSFSTRQIIDVRVLGTHDARKHCFLPISHRAGKTSVYELSAKPSDLVGPIKDIITLDKIELKSSWIAFVNNVTEDCLWVNITPNIRGRITSLEASDDVSRLENLELKFPVGSALKAHVTHIDVASNRLDLSARPKNSTPLSVENLNVGMVVPGKVVKINKSYILVQLSDSLVGQVNLVDLADDYSEANTAKYTRGEIIRVCVCDKDISSKKIRLSTRPSRVLNSSLKVQDPDISSIEQLNVNDIVHGFVKNVSDKGIFVSLSWKITAYARVSDLSDLFIQDWKAQFEIDTLVTGKVISVDIAQNQVQISLKASILEKEYIPPITYESLQVGQLVTGKVRKIEDYGIFIVICGSDNVSGLCHKSELADQRVHDIKKLYEVGDTVKAIILKLEKQKRRVNFGLKTSYFEEISSESDGKLDDTDSDVSVSSKKSVIDDDDSTDSEEGGVYLNEVEGILNSANSRSSVSFGENKNTKTTDKNPVLNAGGFNWTANLDLPDVESDDSSEISDDYQNLKKKKKSKKMKIAIDRTGDLDANEPSSVSDFERLLLGQPESSRLWIQYMAFHVQLGNLSEARATAERAIKTINPKEENEKLNVWIALLNLENVYGSDDTTDEVFTRACQFNDPQEVYERLISILIQSGKHNRADTYFQKLIKKFSLSPAVWYNYAHFLHTQMMSPDRARALLPRATQSLPLHTHLNLTLKFAALEFHSKSGSPERGRTIIEGLLSTFPKRLDIWNQLLDLEIQQGDKEIIRGVFQRFIKSRVLKPKPAKTWFKKWSEWEEKNGDKKDCERVKALAKDWVKNVSELTTSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCN2</accession>
    <name>A0A0B1PCN2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCN2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCN2"/>
    <dbReference type="HOGENOM" id="CLU_003537_1_1_1"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000054">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="116"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1073" mass="116632" checksum="2B103DE471769443" modified="2015-03-04" version="1">MSRNSQGQNHDISKVEDDLNSQPGDTSDRDERASIRSKNSGPKKNIGQIDYTNGNTSTKKKKSTNLEDNDEDADAEEDADAEADGDGDDVGEDSSEDEDEEDEDEEEVHGHRRKRRRERRNQFLDVEAEVDEDEDENDDDEEELNEIKDNFIADTHPDDLAGLPAGIEIDDRRHRELDRRREVEASIDAERQAEILRQRYGAKGRSARGMGESTVVPKRLLLPSVDDPSIWAVKCREGKEREIVYSIMKRIEERMGSKDELAITCAFERGGTNSTMKGFIYVEAQRQADILSALDGIMNVYPRTKMMLVEIKEMPDLLRVSKTPTLQPGAYVRLRRPQKYAGDLAQVQEVTDTGLEMRIRFVPRLDYGVNEDSNAAVDSSGIKRKRIMAGPRPPQRLFSEVEARKRHAKYLHGNANSKTWTYLGEEYVNGYCEKEVKIQHLNTKDINPTLEEVTRFASGAEDGTENLDLNALAASLKASTANASYLPGDVIEVYEGEQKGVMGKAISVQGDIVKMAVTQGVLRGQSIEVPIKGLRKRFNEGDHVKVIGGSRFRDEVGMVVKISEDRVTLLTDQNNTEITVFSKDLREASDSGGSGSLGQFELWDLVQLDPATVACIIKVDRESLVLLDQNSQTRTVMPSQISNKLEKRKHAVATDKNGSEIRIDDVVKETSGENKTGKIIHIHRAYLFLRNTTQTVNAGVFVTRTSSVATVSAKGGRVISSVGVSPDLNSMNPAMKRNPSINGNSEMAAPKIFGRDKSIGQTVTIRKGPYKGLLGIVKETTDSHARVELHTKGKTVSVPKESLGFKDTNSGKSIDLFSKGRFSGAGRGAGMPPRARESFGGSLAVDFNGSRTPIAAGVGRTPAWGNLRTPAAGDHGGRTPAWKVSVEAGNRTPGWVADGSRTVNPYDGSRTAYGGGNRTPAWVSGSKTPAYGAQVDPFSTGSRTPGYTSGGDAWSSKTPAYQQTSNDWASSQPAANNSWGTNAYDAPTPAAHLTSNTSTAINAPTPGPYSAPTPGPYSAPTPAAAPTPAPNWGSGAWGAPTPQPMDAPTPAAQQGYYTAPTPGAYGAPSNWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD60</accession>
    <name>A0A0B1PD60_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000637">
        <property type="protein sequence ID" value="KHJ34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD60"/>
    <dbReference type="HOGENOM" id="CLU_1620291_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="164" mass="18626" checksum="2F522F9D39CC9765" modified="2015-03-04" version="1">MTDSIYGSLEKANWKVMLERRLSTRLRNALVTAHNVPSEYYSFVAYLRQKDAAYQEINYRATTSERPVPAKVMYQFTVSSTTELTVSQGGSAMDLDMLSSEKGPDGRLTPQARNTRRSLGRCYRCNQSGHLAINFHLGKFPRIPVSLFELSLPTESKQLKDQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDA5</accession>
    <name>A0A0B1PDA5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative f-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000621">
        <property type="protein sequence ID" value="KHJ34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDA5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDA5"/>
    <dbReference type="HOGENOM" id="CLU_2005594_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="14114" checksum="4ED27CD5E0D07CFD" modified="2015-03-04" version="1">MPQISEGMLDNLLKLCPKLISLRVSVDYISAKIFRQIPINHTLQILELGCSHTAESDITPNDIFDAVDQFLLPDLRYLRVSSRLVWDSTPELRSDVEDLSELLDTLECENPLHKPSGVWLDLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD6</accession>
    <name>A0A0B1PDD6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000431">
        <property type="protein sequence ID" value="KHJ35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD6"/>
    <dbReference type="HOGENOM" id="CLU_1399387_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="159" mass="17789" checksum="18E6BA0E1ACA0F91" modified="2015-03-04" version="1">MPQSAYNATRFTSTTPHVSQTLNKDKFVRSPRIPGPPHETPQEKVRRLRAAADKARKAQISTLDRWIARGRIWADVAHTITTTTLIAASVIAGGLTAYAVTDMIIYNRRKKAEYFQEQKAQQQLVIDAARKAIQDGTASEAQISIIQMENQRQDSGKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDI4</accession>
    <name>A0A0B1PDI4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lyr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000412">
        <property type="protein sequence ID" value="KHJ35410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDI4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDI4"/>
    <dbReference type="HOGENOM" id="CLU_553425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="53869" checksum="B00FB690B7777467" modified="2015-03-04" version="1">MAPGYRNSTRRQNRSGLVDHDIFEGLPVRQWRRGLVTVEPSSAPEHTIQQNNIWAIELPHGMPKDSHLLPQHSQDLLRAARSGKIYKRPGPVSTEEEEADAEATNGEKVEKKEEPPQDNGFVAKIWKQVPRHLEGPEIEFLAKRRKGLITAAKTSTISATPSLVKTIVKKTDAIGNEYVQEIFVTQGVKAEEEVIPKSNLNSDEQTPQNQSTLLKKKGPVRKKIKPVGRGKKKKSLLPTSAPNDSTICPIQNTQVDDCTTSKGLITSVLANSEDIEIGDESVGNSEDGEADDGEENEEEGEIIENKSILKSAPNAMSDLIMEEDSTTDTGTQYALTVKSEKNIIDCGLNSKNTDTDTDKFNSDSPSNLQFVNVIPEVSETNTLSETVVENTGQSESSTLWESQQGTHEGLSLDQAIPLPIAEVINISKQEVYSESDNRDNSINGDSKMIGLDEGSEGQTVHKINSPILNPTANLLLDTSSGQLENTPATVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDS2</accession>
    <name>A0A0B1PDS2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000702">
        <property type="protein sequence ID" value="KHJ34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDS2"/>
    <dbReference type="STRING" id="52586.A0A0B1PDS2"/>
    <dbReference type="HOGENOM" id="CLU_013127_1_1_1"/>
    <dbReference type="OMA" id="YPQVCES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="648" mass="74350" checksum="AE4384124B633855" modified="2015-03-04" version="1">MAPRSTRKKLYCHYCDCKSHLIFDGTVFQWDCSNCDASNYLDENGDITDPPVAPENSTPSAIRYATTYHSEPASSISDSNIFCALCLKNQHLFTSSLAQYYVDINNNQLEQKNEDSDYHIFRQELERRYPQVCEKCEPAVLQRIKVADKTAKTDHLRLLMDKTRSGQLKKSENSFFSIQTLGRTFWNIGFYGQLIWNFTNVITIFFHNSSGKTKDFLLHLGFDFLQPIFMVTTSRTWAFRTLLCSILSIWWFPKPKNCKKDFTKRITGIKTWYFLQFLTICLRIFFHYVISLEVFFSNTNSSKIIFAHIANSLVTILFAIRANGSIKVDVTPLWNSHLENISLRPQSVSTFDEKSQSMGDILNQIESGSTSLQTREMAPILPTSHKITEELTSSNTSLFSQNSNPQLSGMRHGYQSNNIPSFGKKTNDRMSLSTLKATNEMPNRTTPSLLQMSEEEASSYLKTGNVPSNCTFEEMDWQSTQSSHRAFNPRPKTNIQQFNHIPISSESSPFWFRVPAAPITPAQRLRNPPNQPNLLRPQEKTKQNFFKNMTKSGKCHSELLPAKNDQNELVNYNMELSQPKFFPCETTGEAENMLADLLTGVTLENTHESMRNKSFIFGIHNLNLSVLLSVVAPIFGVFFYLYLHYRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEK1</accession>
    <name>A0A0B1PEK1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000436">
        <property type="protein sequence ID" value="KHJ35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEK1"/>
    <dbReference type="SMR" id="A0A0B1PEK1"/>
    <dbReference type="STRING" id="52586.A0A0B1PEK1"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="6"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="243"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="35006" checksum="1BC883A1A51337CB" modified="2015-03-04" version="1">MKPKIITIIGSLNTDLVTITGRLPSGGETLTATSFFTGLGGKGANQAVACARLSQLSPSAATQSNVTKYINVKFIGAVGADEFGPRIISSLTTDGIDTSRIEVKEGKTTGVAVIIVEEFSGENRILLNPGANHSLVVDQFEQISSLGTPLPNIIILQLEIPLSTVLQILRIAKKAEVEVILNPAPAVVLPTEAYHDLPHLILNESEACILSGRRVSDISREGFDWKIVIKEFLDKGVRNVTVTLGANGALFASNLSDKFTVHHLPAFKVENVVDTTAAGDTFVGSYALGIAKGEKCMKEVIRYACLAAARTIQKRGAQVSIPWSDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEK7</accession>
    <name>A0A0B1PEK7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000433">
        <property type="protein sequence ID" value="KHJ35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEK7"/>
    <dbReference type="STRING" id="52586.A0A0B1PEK7"/>
    <dbReference type="HOGENOM" id="CLU_085820_0_0_1"/>
    <dbReference type="OMA" id="APSHHYH"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17230" checksum="5E91B1B9A71F8051" modified="2015-03-04" version="1">MLSQCSFFTNFLSAFRAHAAIQQAKVSTSSSSTSKKKTSVPHHSHSTSSSSQPLSITSSSKAGATTTATALSSLHSSRAHSSSPLSCSLGTQTMNEKYMPNHASARRGSDSSTEGFTEVHGAEKWYIGGRTANGEEKFFKLGVIRRQRSRDRLSLDRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEW1</accession>
    <name>A0A0B1PEW1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000232">
        <property type="protein sequence ID" value="KHJ35850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEW1"/>
    <dbReference type="HOGENOM" id="CLU_1918619_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14606" checksum="3EE2CE59D6A0EDAE" modified="2015-03-04" version="1">MNFASAAIVITLQNSVLEHFLVKTMARPCTLKILVWLLLGVETVEGLITPTVGYREFQAAARARAVEEKASEMEAIKQNLRGMGDTEATSERVEVMVEIILEISEPDEVRVNILENVKQESVSITADSTMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEY0</accession>
    <name>A0A0B1PEY0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitogen-activated protein kinase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000221">
        <property type="protein sequence ID" value="KHJ35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEY0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEY0"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="MIAKCLM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034307">
        <property type="term" value="P:regulation of ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="67"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="368" mass="41174" checksum="3308D061A276A052" modified="2015-03-04" version="1">MSETIGAARTLKRKNVKGLALSAAPRPTATSENDTQLPGNNKNESTRHSSQLEIGIEYKLNLKREDLEVLKDLGHGNGGTVSKVRHMGTGTVMARKIIHVDANKEMRRRIVRELQIMHDTNSEYIVTFYGAFLSDTNDVIMCMEYMDVGALDRLSRKFGPVRVDVLGKIAEATLGGLTYLYTKHHIMHRDIKPSNILINSKGQIKLCDFGVSGELVNSVADTFVGTSTYMAPERIQGQKYTVKSDVWSFGLSIMELAIGKFPFNASEHLSDDDGAPSGILDLLQQIVYEPAPRLPKSEAFPQVLEDMIQKCMAKDPQERPTPQELFEREPFVQAAKRTPVDLREWAVSLMEKDNRKSHLVKQLSVMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFU6</accession>
    <name>A0A0B1PFU6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000285">
        <property type="protein sequence ID" value="KHJ35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFU6"/>
    <dbReference type="STRING" id="52586.A0A0B1PFU6"/>
    <dbReference type="HOGENOM" id="CLU_020349_0_1_1"/>
    <dbReference type="OMA" id="KYQTAIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="438" mass="50933" checksum="0DE5E8EA2F53ED28" modified="2015-03-04" version="1">MDTLIDTLSVITPGEYIRGSCGYCKNNHGDFSYRVDGVDVTVEFYQKLLDRGWRRSGKLLYKPDQRASCCPAYTIRVDSLEYHPSKDQRQALNRFNKQIIGQKYLAAAAKIFPRNREQSQKRKQEFDLVERIHESESSEQKFPLVHDQAFVVTLEVGNFTEEKYRLFENYQRVVHQQSPNQITRESFIGFLCASPIKEAHKDVNGTLLLTGSYHQCYWIDGKLVAMGVLDLLPQCVSGVYFMCHESVRELNFGKISAMREIALAKEKGYRWWYPGFYIHENVKMKYKRKFAPQQILSPESYQWHLFTKEIRLQLNYSKYIRLTGEENSDQSSLLDESLSQSSRNHQECNSDCHSHFNENLLAPLYMRTVPGTLNTKQLQTEVDLDSILIRLHNDIFQVQELLTWNETTLDDYHSIKSVIAEAVSAVGPELCKNMILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG70</accession>
    <name>A0A0B1PG70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell morphogenesis protein las1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000337">
        <property type="protein sequence ID" value="KHJ35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG70"/>
    <dbReference type="STRING" id="52586.A0A0B1PG70"/>
    <dbReference type="HOGENOM" id="CLU_759096_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="41179" checksum="41CD1DBC2F0CB9E6" modified="2015-03-04" version="1">MNQSNFNYPDSFPNSTIAAVKTHGPDAMDTPFSKCNTVRNYPQLSIPSRPLNRVRKLPSPQRRTCRRTVPVSNENVTDTQRRGSFMNQIVQQQQQQQQIQFWNSQCSMNEYQRQPGLTSSRPSSWHCSSQEPCTYMTPVSAISSYSCNDSNYEHQNNNNNQPISCSAQISTEMSLLNSSPPLSPSIAADSQLPHDFESLLQFCPDPTILESNYCLDKSWPLNSFSQSNRFMHSPYPRDLPDYFQWDFYTPSNYILDDCSLTSPPTPNDTWQSQISDQSCGADKCPSSCCLPKDQAEEEELIGMGLYDYPESCKSPTYHQSIIQSHVAETLGVKFIQCPESQGKGLKLEETFTPSLSDDESGTAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGR6</accession>
    <name>A0A0B1PGR6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000019">
        <property type="protein sequence ID" value="KHJ36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGR6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGR6"/>
    <dbReference type="HOGENOM" id="CLU_002806_0_0_1"/>
    <dbReference type="OMA" id="MEYVGYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="112"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="331"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121478" checksum="57DE290561D5E0DD" modified="2015-03-04" version="1">MQIQTYNPEMSLNQQSNSVPATPHQHLRKFSLESRERSPSATNGHSPRSAFSESNIILPSARFVPRSGGCPYETALANIKRRMPYSIGSDKLEKLNPSSIKSCLSSEEERILSSEMKDLYQKLLPSSECELRRTKLVRKLEKLFNDKWPGHNILVHVFGSSGNCLYTDHSDVDLCITTDKKEMEGVCMIADLLAKSGMEKVICVSTAKVPIVKIWDPELCLACDMNVNNTLALENTRMIKTYVQIDERVRPLAMIIKYWTKRRIVNDAAFGGTLSSYTWICMIINFLQSRNPPILPALHQVNIKHSKSNGGSSFADDIETLRNFGYENKETLGELLFSFFRYYAHEFDYDAFAVSVRQGKKISKIEKGWHLTNNNRLCVEEPFNTGRNLGNTADDTSFRGLHIELRRAFDLISEAKLQECCEKWNFPPEEERRVREPSTKSKIVVRTASTSGGGRGGTQRANRHSSFQYRQNNGINRRSSSGAFEGGPYPIGHPAQNFIPQDAWLQRQAGQAQFSNELCTAFSTLQLNESNIKYHLYSNNLQVQALTQTPAQVHAPTTRIIKSNTSEQSRTSHHEKPSPYSTPIRTQLYYYPAQYPGNSAYQYQNSSRPPQSPLSSTAYSEVSRTVHCPAIASVPRNTDPLTSSTLISHSQSATSSGQQKIILNGAGLTSSNSIIDQAYPFQESGILNPNFTAHNVPDSIRPIANLSVENSAPMEYVGYYIRQKLPGSISRGNEMPIIIPSFSDIAQQKRRHSTDQISQSNQTSISQTSRSPSPLLNDRINNVAICPTFVAESFPIQGVPSGNLMALNSHLPPENGKPNSISVSIPNWQAHVDEASVYEDLAHESKIGSRDIKSYTSCISNGLLPGFEISERVIPIETQRWISNEQRINVNGSAALHVNGNGSKTAVNSSSSSTLTKNLVPISNIALKYQQSPDALNGYHKCLPDSSIRSKHISSNNDAFSTSTEIREFSSKDDLPILSPVFEVPDKTTEENQKIKSFLEMKEKISINSRLGDKKTTIYNQSHPLVNSNGNFSIVSKRHTQSFKGESDGLGSWHQVPRGKKKNTGRVSKGSTSIRGLNEKLPKNISERKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGR8</accession>
    <name>A0A0B1PGR8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative vps52 sac2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000292">
        <property type="protein sequence ID" value="KHJ35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGR8"/>
    <dbReference type="STRING" id="52586.A0A0B1PGR8"/>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="148"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="332"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="654" mass="74138" checksum="52965615B52576CF" modified="2015-03-04" version="1">MWLDRLAGHSTTPDTSGPARPQKVNYLVPTSTLRLPRTSSLSVYSNDSTGSLLVSDFTENSYNKQSLVNTGEKGPLQVLHEILNPSKHEILCIPPEKNYGEMIHDELVDDIDFEGLNLQEIASLPFSGTEEDFTISEIIEECEKDKASLVELHNSILACDEVLSSVESNLVTFRDDLAQVSVDIETIQARSNALSISLDNRKNTEQILGPIVEEISIPIATVRKIVDGSMDEAWVKALADVEKRSKSFDSKIKDRRNIKGIISLKPLLETLICKAIERIRDFLVSQIKVLRSPNVNAQIVQQQQFIRYKDIYLFLHKRHPQLAEEIGQAYMNTMRWYFLNQFTRYEKALAKIKIHLIDKHDALGQDDGTRKSTTVSNSRTPGPIYDAFNLGRRIDLLKTSNQTALSSFLAEEDHSIHYLEFPFRNFNLALMDNASAEYSFLTTFFTPALTNSSITKHFNYIFEPTFSLGHNFTKSFVSDTYDCLGLLICVRLNQSFAFELQRRKVPTLESYINGTSMLLWPRFQLVMDTHCDSVRVLTSSLSIRKQSASEAAKQSTAPHFMTQRFGQFLQSILLLSAEASDDEPVSTSLGRLRGEIESFLTKFSMVMDKRKRDRFMYNNYSLILTIVGEAQGKLAAQQKAHFEEVKKLFATGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHC8</accession>
    <name>A0A0B1PHC8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000197">
        <property type="protein sequence ID" value="KHJ35944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHC8"/>
    <dbReference type="STRING" id="52586.A0A0B1PHC8"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_1_1"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="57371" checksum="0CCA03A96E964C40" modified="2015-03-04" version="1">MALNSYFQNKIESMKLEIIHGQAVLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMGTKKVLVKVHPEGKYVVDVSESVDIGKLTVGKRVTLLSDTYKLEKILPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTACKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRSMNLTRGIDLTKVAEKMNGCSGAELKGVCTEAGMYALRERRVHVTQEDFDLATAKVLNKHDDKEVSLGKLWKENLTYSFCTLSRRVAAVSPQPAPDQLCQQLTFIGGSLSKYGVLHSILPGPIVGGFVKKGAEGKVMWKRRRLRPAVMIGGPEGKDGANLLGYPSYTKHTGRLHRHRLKVKISTLPAHLVLNYCDHLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHV4</accession>
    <name>A0A0B1PHV4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative glycerol proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000045">
        <property type="protein sequence ID" value="KHJ36371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHV4"/>
    <dbReference type="STRING" id="52586.A0A0B1PHV4"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="LQCTSFQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="57872" checksum="31FEDEBA1884C0C7" modified="2015-03-04" version="1">MVFFNLRGSVLSVAQIGLIVAPCFILFGYNQAGIGGLLSLPDWTNTFPEIDTIHTTGARKSQNAVFQGLVVASFVIGAITACMACMFLGDILGRRKSIFIGGLLSLAGEVICSTSNTLGQFVSGRTIIGAAIGIFSSTVPVWQAECSPPEHRGKHVVLDGLFTTLGYALTSWANYGSSRIHMTDQSISWRLPLALPNLFSIIVLLFIFFLPESPRWLIKVGRYQEATEIMSKLKDLPIDSSEIINEVNEMRSALDESVTQKATLKDMFTMGPDKLFFRFCLCILLQFYQQMSGANLISVYGTVIFEQSLDIQSQKAKLLTGGALTWKFFSSFLAFFTIDRFGRRALFMFSGSGMGICMFILSITTAFEKDDSNLAAAYISVISIFLYNFFVPIGFLGANFLYCVEVAPVSLRVGMSAISTANHWLWNFIVIMVTPIAIDRIGHWYFDIYAAIALSIPIVVWLEFPETMGLSLEEIEMLFRNSSKIRTVVKKSLQFKRKGDGFEDNVKDSNENTVDKQLNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUN7</accession>
    <name>A0A0B1NUN7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005219">
        <property type="protein sequence ID" value="KHJ30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUN7"/>
    <dbReference type="STRING" id="52586.A0A0B1NUN7"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="37026" checksum="0790972A7FB37739" modified="2015-03-04" version="1">MKEVENSVTFSTSNNSRVTEALNGQKKARLEYTLDLQVNTGTRGTQKLPNKEKHGWRNLSPAGIHEVIVKKLVISPSLNGKINPVRSGFALSPCSTEARDTILNAGNGLFLSGAKSEPATNWVSVQITTVLSKTRKRQGEVEISISLLSNEIERVCSVRPAHVKLYGRSKPEVPHKTWMGVLVKALQSGFRVFDESGIARSFKQQQPLEFCKRCNGHHPAKNCSRSLSCSNCDSTNNAADSCMTATKCRYCGGPYQPESRRCLACSTRAAALTKEQLKTYRQAGEREYQVVSRATTTDEPSATVEKNNKGLTSSQDSDNTDNIPASPIEISTGDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVI4</accession>
    <name>A0A0B1NVI4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004452">
        <property type="protein sequence ID" value="KHJ30337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVI4"/>
    <dbReference type="HOGENOM" id="CLU_1653449_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17793" checksum="E8A68A08DE175DD6" modified="2015-03-04" version="1">MRNMLQGKQSTWATVVRKGQKKARVRISQDAVSPYITRDSQRSFLQRKGPSTKTQRNLICADKLAPADSKDKRIFLRVPQEHEWRKLSPAGIREALVKMLAISPASISRIKPTDSGSALSPSNNDARELIMKAENGPFLSGTKLEPAINYEPVIIPTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWL0</accession>
    <name>A0A0B1NWL0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01004470">
        <property type="protein sequence ID" value="KHJ30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWL0"/>
    <dbReference type="STRING" id="52586.A0A0B1NWL0"/>
    <dbReference type="HOGENOM" id="CLU_019942_1_2_1"/>
    <dbReference type="OMA" id="LGNCWFR"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="509" mass="55229" checksum="EB4378E68A3E6E6A" modified="2015-03-04" version="1">MLFKTGIIRYRLKGKITSRFLSSTSRYHEINKVYSSAADAIKDLKSNSTILCGGFGLCGVPNTLIDEVAKRPDINGITVVSNNAGTDDSGLGKLLKTKQIRKMIASYIGENDTFERMYLTGEIELELTPQGTLAERCASGGRGIPAFYTPAAVGTVVQAGELPLSYNHDSIPLKYSVPKEVRIFDGRPYLLEESIKGDYALVKAWKADRLGNCQFRLAGNNFNGVMGRNANKTIVEAENIVMPGEISPEYIHLPGIYVARIIQSTSPKSIERYTFSEDSYTSKIVKAYGETASKRERIVRRAAKEFKNGMYANLGIGMPMLAPAFIEQGIDVQLQSENGVLGLGPYPKRGEEDADIINAGKETVTLNVGASVFGSEESFGMIRSGRINLTILGAMQVSQKGDLASWMLPGKVKGFGGAMDLVSNPSKTKVVVTMEHTDKKGNAKIVKQCDFPLTGKACVSMIITELGVFDVNALSGITLKEIADGVTVEEIKAKTQAPFSIANNLRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWM7</accession>
    <name>A0A0B1NWM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004421">
        <property type="protein sequence ID" value="KHJ30353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWM7"/>
    <dbReference type="STRING" id="52586.A0A0B1NWM7"/>
    <dbReference type="HOGENOM" id="CLU_783457_0_0_1"/>
    <dbReference type="OMA" id="THENSFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39243" checksum="A3A4FEEFFB7BF175" modified="2015-03-04" version="1">MILVWPFGRAVMHLSLVLCRIVPLSLSSYLVLVTLSTCCFRHTATNAVEDSLSPMLIGGNKSFVDSLRVFLRASIAQFLQVGPGAAPPKLPMVPPRTLLTVAKTHENSFPSLGPKTCAISPAQQEPSEQRQDGSWVTALKRGNSKHRSQPKSWTATSSGQSKKLATTLSQKQKTGVQNNGVAKSISKDDRLFDRFFQRIPRNHEWRSFTPAGIREAIIRKLGCPPTTIDRIIPVASGYAIVAKDETGRQLLLSLSHRLPEDILLEAARDWVSYMLPNIPSYIVTIKGRKPVAESEVIAELERVTGLIPKSVRYRGKSKVEAPYRTWMVFFDKDSAHKPGFRLFDDSGRAASLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWQ0</accession>
    <name>A0A0B1NWQ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative g patch domain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004362">
        <property type="protein sequence ID" value="KHJ30383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWQ0"/>
    <dbReference type="STRING" id="52586.A0A0B1NWQ0"/>
    <dbReference type="HOGENOM" id="CLU_089381_1_0_1"/>
    <dbReference type="OMA" id="YARMNEY"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="17385" checksum="A757F6821BAB8D19" modified="2015-03-04" version="1">MPPRGFTNPSPKTESAREAVKSFYCELCSKGYARMNEYESHLSSYDHSHKQRLREMRQLTKDPLASSRARKAEMKVNSQAGLISIKIGGDINNSTAKKAGFKKAGFKSAFAPADGSAPTTIPGNKGEGVEESKISDKEIESDTEDEGYEVYDPRCPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWZ4</accession>
    <name>A0A0B1NWZ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c2h2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003496">
        <property type="protein sequence ID" value="KHJ30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWZ4"/>
    <dbReference type="STRING" id="52586.A0A0B1NWZ4"/>
    <dbReference type="HOGENOM" id="CLU_031491_1_0_1"/>
    <dbReference type="OMA" id="MTHIEEG"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="31772" checksum="5DBFFE50D635D75D" modified="2015-03-04" version="1">MHPLSQNLKCQGCSKTFPRLGALVAHIESSQCKSMTESHLSIIRENKLRAYETQKAARNFKDFNRCGFPTEYDVEPLPLSLSTDRQVKNQNNSTLSNHMKNDGNEDLINFESRPTILNSVPGISNEPTRWTSLDPNLNQTESNVTDNYPTSKQTQAIIDPNIPGFRAENFFIPLLMKYKCPHKSCGKTFKNKTGFMQHLNSQAHRNEELKCINCLKHFATATALTQHCESQSLRCKIRDSDSYEQMVDIMTSGFATITGRLPDNTVKYSTTKSVRTKNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXK0</accession>
    <name>A0A0B1NXK0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003741">
        <property type="protein sequence ID" value="KHJ30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXK0"/>
    <dbReference type="STRING" id="52586.A0A0B1NXK0"/>
    <dbReference type="HOGENOM" id="CLU_069674_0_0_1"/>
    <dbReference type="OMA" id="GMIMLAD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="317" mass="35113" checksum="B94CF3EBCCCEFB6A" modified="2015-03-04" version="1">MLLLRCPSINLLIPALHPKLSRKKKKTIKSNRAFLLLHCRSRLAYDSGMTSTSVAAHDITIGILALQGAFREHTMILRQSACKLVTRRKWIFKEVRTVSELDSCDALIIPGGESTAISLIAQQTNLLEPLRNFVKVLKKPTWGTCAGLILLAEATNGSKEGGQELIGGLDVQVNRNHFGRQVESFEAELDLSFLGEINAHESSSPLEPEPPFKAIFIRAPIVEHILHSKSDAHPTKALTDNSTVTQSCDTINNREPVEILARVPAADAETGAIVAVRQANIFGTSFHPELTGDIRIHVWWLEQVLQMIDQKRSVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXR5</accession>
    <name>A0A0B1NXR5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0754</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003151">
        <property type="protein sequence ID" value="KHJ31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXR5"/>
    <dbReference type="STRING" id="52586.A0A0B1NXR5"/>
    <dbReference type="HOGENOM" id="CLU_004553_1_2_1"/>
    <dbReference type="OMA" id="EYIVTHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="367"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1030" mass="117900" checksum="BA00851779025AA3" modified="2015-03-04" version="1">MPFLRNSLRRIRDSAYYSNVSSSPGTTIPRKTEAIDINSRPRASSTTKDFLIRNSVNKCSIDISEEDSNNARAVKLGETYCYKSEDKEVIITLDISHDRKPLSDSEVDERKLIKNETLECDRLYRPLSMNMSKSWNTEYRILFKDIDFKKSNGEIFCFRARIHTLRRLSSNMVFIIFRQQTITIQGILQSSRQPERLIRNSEHKTCIEPITEKMVRYVEHLPSETLVLVRAKLREAPHIIKNATIHNYEFEVHEIHKISDLTENVPFTVYDAENISRGRDDDEEENSLIDFDKDEGQIASPISSNSSAPNEKFSCISPVTPVLGHTSVTKSRKSDETYKKRSRSLPQRVRLNNRIVDLRTGPSQSIFRIQAGICNSFRSYLDSKGFLEIHTPKIQGGATESGASVFEVNYFGRPAFLAQSPQLAKQMCIAADFERVYEIGPVFRAEDSNTTRHLTEFTGLDLEMAIEEHYYEALSIIDGMLKNLWKELYQRYQPEIDLISQVYRHERILWLEDTLHISFSEGVKMLQEVGWTDDNGNMPSNTEDLSTRAEARLGALIKEKYKTDYYILDKFPASARPFYAMPDPKDDRFTNSFDIFLRGQEIISGGQRIHDAKFLEKQMKKNGLRLESMPDYLEGFRWGAPPHAGCGIGLERLTSLFLNLGNIRLASIFPLDPKSFPKKPQALKLRYEEASTINSPLGGYDLDRICSLQPLERLIANYGDAANTTWLDEQYHVWRHPSSGAAQGYVINSGHAIIIGDTLCDKSQYQQIISSFLQFIQDHRDLKPIWLIAGPITEKILGEKHSWRTIGCIAEERIDPRNNPAMKDKDLARKIRHAHNEGVRELKLINSQPTYEDIRTKIGSRIHDWHKNRKGTQVHLTKIRPWVDQEHRRYFYSHTIDGKIHALVVLHKLSPENGYQIKISLEFPGAPSGTIESLILYSMKSIVSEDPEIKQVTFGTGALPILNGGRNIGNFKVKALKKAYSKLYQQLKLNNKSEFREKMGVWIDPVYVCYPRGGLGPSAIRAIMGFLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY23</accession>
    <name>A0A0B1NY23_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003538">
        <property type="protein sequence ID" value="KHJ30848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY23"/>
    <dbReference type="STRING" id="52586.A0A0B1NY23"/>
    <dbReference type="HOGENOM" id="CLU_511984_0_0_1"/>
    <dbReference type="OMA" id="WINEVRY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="527" mass="60320" checksum="B3804B24A6C1E1E9" modified="2015-03-04" version="1">MSISSLLENLETNLPKDVTFKVYYLSTFENIASSLYRKIPGQQDDKTSCTKHFLVLTVKLPFNDNKDHNKEVIVYALEVYIYSTAQNITIFVSKADSTGYLDTLKLTKSIPSPIRTVSTTFLQYLITKYQRPGYKTIVSLFARAQDQYLFPRSVEYPGKHVQHDSGLIRWWCRVLNPIVETSQTDSKTAKGYILIPGLDKNETLSFVPNKVDNLWTVGHPLLEITTLVGTVAPRYLIPHFPDDPKARFLDELDGELIKCGDSNGHWRSIKTLDQFWEMMAFRQECSAGRLVGFIWIVISPKQYYVQNRSANNSTEAPKLVNDNKQEFNNDGPPKLYPHCKSLKNIQTLSPHLMNRTDTEKKLEQSSVNHQSKSSTSLKTLRQPHNRKKILTGRIITREPRYKMHNSNFPPLISSHIKQKTKYRKALQAPGQIIVNETIYNRIMELLLRLDFSKLELAISNSNRWIEEARYAGYGAMKEAWGQTVIGKKAVDACLNTATLSLNTLEPRMLQKRRKKANAEETPSENVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY95</accession>
    <name>A0A0B1NY95_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003001">
        <property type="protein sequence ID" value="KHJ31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY95"/>
    <dbReference type="STRING" id="52586.A0A0B1NY95"/>
    <dbReference type="HOGENOM" id="CLU_1321761_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="23101" checksum="5BB20D6DD92D6181" modified="2015-03-04" version="1">MSYEFNPPSLYDPASPNPNTPNHIPIVNTGRSPPSQQLNPKFLDLDDPDPDGSLTQDTISCDDYPPSGPIEQALRTSKEAAKQRALEAEIIFGPISKMLYQHCSSTTQMPPKLAHALREFRDDLTKLAARHFEAYLSGIPTSTNQTLEKPSQLNYVQAAKSRPSVTAKVPPSNKYSIKDKKAQIIADERLFLRLSEDSPLRTYSGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYM9</accession>
    <name>A0A0B1NYM9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002851">
        <property type="protein sequence ID" value="KHJ31497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYM9"/>
    <dbReference type="HOGENOM" id="CLU_1769467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="147" mass="16767" checksum="B5DEC657CA186323" modified="2015-03-04" version="1">MSSTLLTNHYYCMSCEEVIPDTSLCSKHYFECNSPHILRIRLVAHPKENQKNRSHSSKNNGIPRNASPSTSCTRDTAPKFSNASLSEQNPGKVQEFLPNNGSPRKATPYTCKAQNDSRRNGKTYVYGNKEVINNNYWKQKQHEFTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYN1</accession>
    <name>A0A0B1NYN1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003261">
        <property type="protein sequence ID" value="KHJ31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYN1"/>
    <dbReference type="STRING" id="52586.A0A0B1NYN1"/>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="24204" checksum="F637C644B0BF8714" modified="2015-03-04" version="1">MSKITVAGVRSNVQQLLEYSTETKKRNFLETVELQIGLKNYDPQRDKRFSGTIRLPVIPRPAMSICVLGDQHDIDRAKHGGIDAMSADDLKKLNKNKKLIKKLARKYDAFVASDTLIKQIPRLLGPGLSKAGKFPTPVSHNDDLNNKLNEVKSTIKFQLKKVLCMGVAIGNVSMTEDQLISNIMLAINYLVSLLKKGWQNVGSLTIKASMSPPKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYS0</accession>
    <name>A0A0B1NYS0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4684</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="JNVN01003222">
        <property type="protein sequence ID" value="KHJ31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYS0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYS0"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_0_1"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="26924" checksum="2C438CD1FB86AEB8" modified="2015-03-04" version="1">MSRRFFVGGNFKMNGTVASIKEIAQNLKQANLDPKTEVVVAPPSLYLSVARESFPSNIQIAAQNVFDKSNGAYTGEVSVSQLVDLGISWTILGHSERRTIFNEDDKFVASKTKAALDGGVKVIFCCGESLEQREQEKTIEVVNSQLKALKEKISDWSNIVIAYEPIWAIGTGKVASPEQAQEVHLAIREWLKTQVSAKVSEGIRIIYGGSVNENNCKSLSVQSDIDGFLVGGASLKPGFIDIINSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH0</accession>
    <name>A0A0B1NZH0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hmg box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002966">
        <property type="protein sequence ID" value="KHJ31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZH0"/>
    <dbReference type="HOGENOM" id="CLU_048021_2_0_1"/>
    <dbReference type="OMA" id="WVKSHTP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="36445" checksum="56E5051DC44428BA" modified="2015-03-04" version="1">MLLSSIGRSSLERVLAITSSSTSIALQSIKYFQRIPTTICHKDIPAGIISINFTKRQYSNSSRLDAIAKSRSGIPAGKSTRVSKSSVSKVKNKSQKLKQIKRKQTTVLVKKPRKAKKVLSELEKKIVKTISLKSKALRTPKKLPSSARTVYMAVNLKGTSGGEITSKFAEVSKGWKNISQSARERFEILAKANRVANDNKLKEWLSQYTPEQIRIANNARKQITKMGELKRYWKKIPDERLPKHPTSRFLCFVQERFNSGDFKGVDILEASKQLATEYFALSPTEHKKYQDMFIQSRNKYIKDYVAAFNREPQRVKKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX3</accession>
    <name>A0A0B1NZX3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01003921">
        <property type="protein sequence ID" value="KHJ30590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX3"/>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="OMA" id="RKFPKCY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="46474" checksum="1094A005690D37F9" modified="2015-03-04" version="1">MASHGVARPTTIGSRTEQEKRKEYTEIQDYRELEKTLQMKVAEQGYTLEVFNLTSKLLKKNPEYYTIWNIRRRILIQCLFSTSPSQPLLPNELAASPIYNSRTQVLHINSQPDQALQNRASELRQNVLELITSDLRFLFPLMLKFPKCYWLWNYRLWLLQQANERLDIKISRELWTRELDSVAKLLIKDSRNFHGWGYRRLIVAQLESCGLNGSSMVESEFEYTTKMIHAPNGLSNFSAWHRRSKLIPRLLNERQSTSCARRQFLDNEFDLIVSAMYTDSYPYQQSAWFYYQFLMTALIEPNLCPIVDFSIEERCNYINQQLNVLKEMLDGAEDCKWIYNALIDYTVSLRQLEQRELQSGDKINCKSWLTRLKVIDPFRNGRWNDLENALGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P074</accession>
    <name>A0A0B1P074_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative calcium calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002704">
        <property type="protein sequence ID" value="KHJ31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P074"/>
    <dbReference type="STRING" id="52586.A0A0B1P074"/>
    <dbReference type="HOGENOM" id="CLU_006421_1_0_1"/>
    <dbReference type="OMA" id="KQYYYIV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="607" mass="68713" checksum="E416A21E05E3BD40" modified="2015-03-04" version="1">MNVICLCHKNSIISSRLMESKHELSRLSLQSLVHQKPLDNVSRVADDQRRSDTPCTSRDAKTSVEQKEKKIVKIDKEDLARLVAEENEMKGMLPNYTGLERWKLIEKMGDGAFSNVYRARDLQGQFGEVAIKVVHKYEMNSIQGEARLHPNFKKKPKVVERANILKEVTIMRGLDHPNIIKLIDFTESEQFYYIILELAPGGELFHQIVRLTYFSEDLSRHVIVQVARALEYLHEEKGVVHRDIKPENLLYCPIPTIPSKILKPKAPGDEDKVDEGEFVPGVGAGGIGQIKIADFGLSKIVWESSTMTPCGTVGYTAPEIVRDERYSKSVDMWAMGCVLYTLLCGFPPFYDESIQVLTEKVAKGQYTFLSPWWDEISKSAQDLISHLLTVDPAKRYTIKEFLAHPWIRNSREPTFAAPDAPPLATPAIERQKQLGGSLRAFHPEFLESPGGGKRMDFRSPGAINLREVFDVGYAVHRQEEEVKHRKNLAGGQRVTFQFNSLNPIDDEDELEEQNDETEYSDETKTPKAKESNLQYVEQVMRKTNLNSNRVPQQKGYGQHSAAVTAAAKQQVRNQKATFELNLEGATLLGRRGMKGLSGLRETTVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0B6</accession>
    <name>A0A0B1P0B6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002349">
        <property type="protein sequence ID" value="KHJ32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0B6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0B6"/>
    <dbReference type="HOGENOM" id="CLU_676514_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45316" checksum="EC545A6AA9809053" modified="2015-03-04" version="1">MSFRVPDFPDTLALSSSAVNSFISFETSDVMNEIPGIQNTTNPLLEHNPSGSKNITLLPPHLWNLPYVTFSPELLEATTQHDPERVSQLFSSSNDPQTPNPPTSSQPRPYLPVQPITPYDGTPGNLRLFCSQLANRLQGNKSISEAEKVSFTYQCLGTGALSKMRSSFRCLEDPSIPPEIITLEGFLTALKQRCEDPSLRDQATTTVEGLFQKNIKFHEFITIFEDNMVDSIYSTVDKSHWKLMLERRLSSRLRNLILTASDVPTEYHAFVAYLRQKDAGLQDILATSRTGLSRHSIPITNPTPSFRPFPPPTPPQLHPQVQSQHLNLPVSQGDSAMDLDSISRQKDADGRLTQQAKDARRTLGRCVWCNKPGYIAKNCPLGTRTVATASVDTTPSLTEEIKDPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C3</accession>
    <name>A0A0B1P0C3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002651">
        <property type="protein sequence ID" value="KHJ31693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C3"/>
    <dbReference type="SMR" id="A0A0B1P0C3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0C3"/>
    <dbReference type="HOGENOM" id="CLU_1373123_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080409" evidence="3">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="21175" checksum="DE44DEE6A1984698" modified="2015-03-04" version="1">MRFFIGAFVTTLIMSPVSVLSMAIGTESTALESRSSESFTKRQVDNFGQSVVSSSFLEKRFCLKPGGCNKKYLKRSSGFQCKKKYISPEKIERAKAAGCPKIREDNQRSTFPSLYTASDFAVPGPYLEWPISRNGRFWNKLRKGKYRIIMTKSCKVVGVVIREKKSSYRTCKDLSREENEDEESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H5</accession>
    <name>A0A0B1P0H5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1728</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01004296">
        <property type="protein sequence ID" value="KHJ30411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0H5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0H5"/>
    <dbReference type="HOGENOM" id="CLU_036590_5_0_1"/>
    <dbReference type="OMA" id="HYLRYHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="52"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="289" mass="31884" checksum="1C4B87CC5984517B" modified="2015-03-04" version="1">MWDVHKFIASNFFNMASVESLDICSELTNSLAIYLPSKVKTEENINTKNRLPHVTVTYAASLESAIAIAPKTTTLISGYQSKAMTHYLRAKYDAILIGSTTAITDDPRLTSRWIGVNTAANPLDQQPRPIIMDPSGRWLNGLTGEENLLRLARNGHGHAPWVITDKNISIKPEALTHLLSTGGRWLEVYLNYEGKSEGVNWEAVLSEIVSLGILSLMIEGGATVINDLLRKKNRHYITSIIVTIAPIYLGTGGVVVSPQRIEGNDDDSFKLREIRWIPMGNDVVMAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I7</accession>
    <name>A0A0B1P0I7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g1542</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="JNVN01002273">
        <property type="protein sequence ID" value="KHJ32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0I7"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="OMA" id="EQMGEYC"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="114"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="599"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="811" mass="88226" checksum="E3710157CA8E1885" modified="2015-03-04" version="1">MSNLQFSIARYHSSTRNGLIMISRKVGPKCLLQSSVRNLFFCHLDRPQSFRTLTNSSLHKASGSFQVSDASPNFHAHLLSSTKDVHRGIPQNLTEKIVQKYSLGLAKGKKVISGDYVTLSPQHCMTHDNSWPVALKFMSIGATKIHNPKQIVMALDHDVQNKSDANLKKYKQIEDFARQHGIDFYPAGFGIGHQIMVEEGYAWPGNMTVASDSHSNMYGGVGCLGTAIVRTDAASIWATGRTWWQIPPVARVVFTGELPRGVTGKDIIIALCGLFNQDEVLNHAIEFTGSKTTMQSIPIDHRLTIANMTTEWGALTGLFPVDSVLEFWLKSKVTAAAVLNQQNHRLSHVRIDELAKKKLLADPGATYAKTLYLDLSTLYPFVSGPNSVKIATPLREIEAKNIEIDKAYLISCTNSRASDLAAAAKVFKDAFDAGEPAEISSRVKFYVAAASKSEQKVAEEAGDWQILLKAGAISLPAGCGPCIGLGTGLLEPGEVGISSSNRNFKGRMGSPDAKAYLASPEVVAASALRGKICGPGWYKEPHKVGKVVIGEGSGNTEEDKAISIEEALDKLVSEADSIVSSAESELLGTKRVEGDETLTEILPGFPEKVEGEIIFCDADNINTDGIYPGKYTYLDNISSEKMAQVCMENYDTEFGSIAREGDILVSGFNFGCGSSREQAATAILAKKIPLVVCGSFGSIFARNSINNALMGVECPRLVQRLREHFSSSDNQVLSQEAGNSKSSTFSQPIISSKNGLTRRTGWRLAWDVRRSKLIITETEGKTWSQKVGELPPNVQEIIARGGLEKWVKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P6</accession>
    <name>A0A0B1P0P6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003541">
        <property type="protein sequence ID" value="KHJ30845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P6"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="89" mass="9712" checksum="A642FAD6AC577E28" modified="2015-03-04" version="1">MHTEDICMAATKCRNCGGPHRSDSRRCLARPTRSGIPTKKQLKSCRQSGEREFKAVARVKEADLKAATAEESILGVDSSQKTDSNSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0W1</accession>
    <name>A0A0B1P0W1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative deacetylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002537">
        <property type="protein sequence ID" value="KHJ31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0W1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0W1"/>
    <dbReference type="HOGENOM" id="CLU_074873_0_1_1"/>
    <dbReference type="OMA" id="WRLMQES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="2">
        <location>
            <begin position="125"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="193" mass="21961" checksum="F0929A0F69E6CE9F" modified="2015-03-04" version="1">MDEDFELKLSVPKPYKPSKSHKTLVDLAAETNHNMAERERFADASPGRMAEATLWTSTYTMLHFTLDLLVTHQYATEVEWSQILRRAIKAFPVILLLIYAFHPHPSPSSIPIPTFSRHFQFVLHQTSFFVASITAGAYLIHTTNVHPYYAIMKQVPPLGCLWVWSMIELDILPAVTSIVFCGVYLKMSGYSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P141</accession>
    <name>A0A0B1P141_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EV44_g2281</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="JNVN01004028">
        <property type="protein sequence ID" value="KHJ30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P141"/>
    <dbReference type="SMR" id="A0A0B1P141"/>
    <dbReference type="STRING" id="52586.A0A0B1P141"/>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KHJ30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="45039" checksum="A09CEE8EA307A63C" modified="2015-03-04" version="1">MTLSCTFPTYLPDEIAGHNNSKSCFVLMGTKVYDVTDFINSHPGGGDLILEYAGKDVTSILKNENSHTHSEAAYDVLEESLVGFIQPRDIFGAKTENAVSHEITLLPPTDDYLSKKEEYHKKPQFPSTGMSSAEDLSRETNIEEDFKTHRFLDLNKPLLMQVWNGGFSKDFYLEQIHRPRHFKGGASAPLFGNFLEPLSKTVWWVVPMVWLPFVIYGLYIARPGLSSTAEEFLYCLIGIFIWTLVEYFLHRFLFHLDRFLPENRVALTLHFLLHGIHHYLPMDKLRLVMPPALFLVLATPFWKLAHVLIYWNWSIATTVFCGGIFGYICYDLTHYFLHHRTLPLYWRELKKYHLQHHFMDYENGFGVTSRFWDVVFGTQLVTNPTKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C5</accession>
    <name>A0A0B1P1C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative lim domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003727">
        <property type="protein sequence ID" value="KHJ30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C5"/>
    <dbReference type="HOGENOM" id="CLU_379067_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="584"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="648"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="731" mass="81105" checksum="306E14E4D3986DAD" modified="2015-03-04" version="1">MPDSTFLQPGPFTPISLLSSPASISRLPFSNSNQSPSNTLSGNLTPKEPLSPDKISPTSEIPSSRNPLLNSRLDEKSEQAMNKIRSGTSSDNEPNQMSAVINPKSIDNSDFFLKVNKIAPGPFDINAKVDIPDHAENDNHRKLSVGDPSDTIAGKSFLGRVDNRPPLVRGHFHKNSGSLINSKTNYTTLPKVPRKSGYDGFGPPSSDSNGISKPRSSSDSQYFLPTNKLSPQLPTISNLELENQITSSEEEVNKSEGSDISKSISDQVSTLSVEIDNKKLDKLQPLQLQENIDESPKSPPPSKNFDKLLPLPYEEKNNELPTPPPQIVLDEIPLLPPKDKVYKLLPSPPQENIDQPPSPLPQKNLDEISLLPPKNKVDKSLPLPPPDKFDEILLPPSQIDLEKRPQFGINNQEDDQPSLLEKPNDIEENSNSKSYDPNIQKYQRRNSKLSHINNLMADIESTMSGLGLNERLSTGSSSSSSTQISIPTTDKSLSNFNSKQQISRQNKIPINPPLSLIPAATLHSSIFLNNHNGKRPIFSQKNSSSTKSSGVSPINGVHLIGLPTNPSPRFRTRSPLDKPRKSKGKCKECGEDIYGKSVSSADGRLTGRYHKECFVCRICQKPFNSTSCYVINDAPYCEAHYHEINGSICFTCNKGIEGKYVETDRRQKHHPSCLRCADCGHILQNNYFEMNGLLYCKRDAYQRAKQNNYLNSEMNEKSSQIDRQPKRLVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1R6</accession>
    <name>A0A0B1P1R6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003582">
        <property type="protein sequence ID" value="KHJ30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1R6"/>
    <dbReference type="HOGENOM" id="CLU_1062438_0_0_1"/>
    <dbReference type="OMA" id="GARKMIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="317" mass="35270" checksum="01964D14389E68A4" modified="2015-03-04" version="1">MKEVIGARKMINGQVKVYFTGEETRKIMETQKGWTQKLATTAHMARPSYQVLIHDMPLTFDPENPEQIMELQKTNTLYIPGITIQKAAWLKRSKTPNKTSGSLIVWFDGAEQADIAISKGVMWKCDLKATEIFRSGFRLTQCFNCQKYGHIAKICTAGPKCGHCAGGHDTRTCSKNQETRCSNCSRKHTAWDQMCPVRLAAKSKVVKNRTQDPGRFTTQETQAGNLDSEWQIIGSRKRRAGLSTIEIAKPVGEGNTRRGPGRPRKAPSFAIQDTSNTIADLTTIASIPIAFTHSDTRTVTWDNDMVATEAPESEMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C5</accession>
    <name>A0A0B1P2C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002848">
        <property type="protein sequence ID" value="KHJ31500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2C5"/>
    <dbReference type="HOGENOM" id="CLU_638085_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="48527" checksum="9025A7C2CFEE622B" modified="2015-03-04" version="1">MPFDFAAYKAKCDALTTQELQLEWQNYTRQLTSGATLTTTSVMMSPLTSGISLVALGISVPQIHNARRKRAIIGNKLQSHGMGPHTRRRDIIIPAAITITTSGLTLGATPLGSELIGGEAGVKGIEYLATHVVLDTMWAILDEAQNSFHHRRSKRKLKRMQSQQRQHLARDMKSDEYSKHSLDMKKSFLEDGDFPSARRGLRSYYIEEDDYYYNREQQAPPPAYSKKYVYQRGQVQFAYDSQASHGRQTSYTHPSTVSNRRRHYSSSGLGSGSAIENLGLLRSSAAARRSSAHGNSRPAIYRPTVCQANRSSYSKKHLIPRYQMEEICENESALESDLESEDEISDQDKSNDEEDDEDSDSDRDSDSDSDSDNDEDSDVENEKPRTGKTTEHVLTLEQEINILKATILRLEMEKRGLMTETKKKKRQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C7</accession>
    <name>A0A0B1P2C7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002075">
        <property type="protein sequence ID" value="KHJ32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2C7"/>
    <dbReference type="HOGENOM" id="CLU_074407_1_2_1"/>
    <dbReference type="OMA" id="HIQTTYA"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="194" mass="22423" checksum="BC2DD5E289CC1DE2" modified="2015-03-04" version="1">MAGGRMKYRHLGRKSSHRQALLRNLVTSLFTHESISTTWPKAKEAQRLAEKLITLGKRNTEASKRKASSIFFTPHELIPKLFGPIRERYANRPGGYTRVLRIEPLKEDQAPSAILELVDGPKDIRFAITARTVSRLRLEGKKINEKTEFFHKKVTQFRPNGEIEFEKMVKRLGEIDIIERSNSDNKERRWGGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G5</accession>
    <name>A0A0B1P2G5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001776">
        <property type="protein sequence ID" value="KHJ32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G5"/>
    <dbReference type="HOGENOM" id="CLU_059789_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="40454" checksum="2395E15A0A4F0819" modified="2015-03-04" version="1">MDKENNWGIPILSGNNHDSWFCRYKVKLTGKGVFYVVEQTVSEACQIASVDSLTKGVEKLDLKQEQNSSTSRTEGLVNLEKKEKYLRDEATAIDFLFKSLSLDDQALNDEYDTAYDLWFYVNKTYQQTDPTTANEYMTLIQKFTIGDMSIINAWDKLKDLRRKLCTADPEAKDTYRDRVLLLILIRALPKDFTSTIDTLDAQPDLSVEEKLKRLQIKESRLVNESKQDQAFVGFTRNSESKPYMNRTRLQASEGDESGYTPECYICDRRHFVKACPFMEVARLAVQDYIRQEKLMKKHNLKPLPNSKNPSRPSSLPKHRKRTDLKKSKAYEALSQSNSDTEASLTTDESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2K1</accession>
    <name>A0A0B1P2K1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003498">
        <property type="protein sequence ID" value="KHJ30869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2K1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2K1"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="31388" checksum="8D2E47769348DAAE" modified="2015-03-04" version="1">MTQSANNQTNQIPTYLPKELRDFIQERQDRKRAWHSRLSTCASVLFNIESTLEMYKGDLEKPEADLIRGYLQKAIVRLAASKNVPKPPPIPLKTKPLKSNVRKGQNLERKKLSSGTSKSPTNQSILKPQKVTFEVYNKSAIVKSSWIIVARNGRKKSRIIASTPSVPSAKISAIQKNMPQASNLNQSHKQKVIVPISDSRLFVHLPINQEWCTFSPSGLREVIVKRLGVSPASIGLIKPVRTGLFLAHVAVRHERLSCRLAAGSLILVLRLNLLRTGYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N2</accession>
    <name>A0A0B1P2N2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cell division cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003468">
        <property type="protein sequence ID" value="KHJ30909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2N2"/>
    <dbReference type="HOGENOM" id="CLU_018320_2_0_1"/>
    <dbReference type="OMA" id="ERCLYHS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="9"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="665" mass="75917" checksum="1F748BB3BEE51ACE" modified="2015-03-04" version="1">MQSLDTVSLRKILQEAVIKCSERCLYQSAKWAAEFLTSMPNSDKDTQPEDPQLTEVRDDNFLPVAISRNSNPEEAYLEAKEINSYLLAKSLFDCREFDRCAEVFLPDTVLQGIISTPTGKGTCNSENPLDKGKGPQLNLKNERKFPQLSQKSLFLSLYAKFISGEKIKEEESEMVMGPHDGGQTVNKQLITISRFLKSWLETRADESGNFSGSEGWLEFLYGLVLAKKKDEEEAMRWLIKSVHICPINWACWLEITSLIGRMDDLNRISLRLPQNVFFYIFFIHTSLELYQESPSLSNSLSQLAEVFPQSPFILTSLGIMAYHTKDFVTAEAHFANLLTLHPYRLDYLDQYSNILYVMNYRPKLSFLAHICSNVDKFRPETCVVIGNYYSLISSHEKSVQYFRRALTLDRSFLSAWTLMGHEYVELKNTHAAIESYRRAVDINRKDYRAWYGLGQTYEVLEMHAYALWYYKRASGLRPWDGKMWQAVGQCLKQMGRDQESIKALKRALISDSHYDKVNNKDRSGILDPEILLEIANAYERLGNEAEAKSYMETCLAQEEGSSEIHETSAMEIPTGDSQSSEDEVRLAPESQGNGTGVTAATSKARMWLAKYAMRTGDYERALQLGTELCQDGVEIEEAKALVKETRMRRMVAVESLDTEGDRGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N7</accession>
    <name>A0A0B1P2N7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003147">
        <property type="protein sequence ID" value="KHJ31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2N7"/>
    <dbReference type="HOGENOM" id="CLU_043294_0_0_1"/>
    <dbReference type="OMA" id="GSWHVSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="335" mass="37180" checksum="D5E47BA397B80C3E" modified="2015-03-04" version="1">MEVSMCPKDTQVKTDHNTSNEVSRPAFAPALSSSRALARFEFEAGKGNEGTKILMVEWIDDERESNWLVSWEGKRTVLPAKDIPGDKLVRIYFLLAPDANIPRIVYISRVGEKSQQMQTNPLPAIFPPELGITTQIRKGVLHTIWAKKRLSALEEEITLEMKNGEGVGLEMALREKKWIEDNFGVISKSTPELQSPMSTSPATPPWDAQSTPILKNISLAKDIPQTNTLNLTDESSLHSLSLDINDVALSSFPLFDSSGFVSKSSQIEQNFQPLQEKTELIKQKISKSGIYHPIDSVADGTISMKQIAEADDGLFALKLSPRSPEMTRSPFSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T3</accession>
    <name>A0A0B1P2T3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mgs207 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001678">
        <property type="protein sequence ID" value="KHJ32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T3"/>
    <dbReference type="HOGENOM" id="CLU_036627_0_0_1"/>
    <dbReference type="OMA" id="NHWNAWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="49614" checksum="F1E1542B2543EEB9" modified="2015-03-04" version="1">MSAPMIAWEPIVNRLFRYITIGSDTSTSEISFELPPVQVHDVETAAAGKRLRTLKHLLRANHINHAIFYSNLIFHNHMPHLLGSAYILGADVEQLHNIYDKESKELAPWSPSPAEITSKEWRNFLSDKRYQRAYIDFFEDELALKFHYNWRDLVNEYLFHGEEPLINGITSGLGHPLIHLAYAFELSCKELAIEALAQASLEYDFMHKYLDDPSYTKPSTTFTSTSPLKILQKIHDDTRFDNIFTQPGPTNIEPLFSQCENQVLEYWNSWTIENPIEQFKDSQNDAITLLTQTVESGHNKFDFFLVHILTTSHAIRILLPLIPPRFHLNLVRQWWLLTIAVYIAQLRPVIRNNPVELPPNKDWNYVQNQAIRGTWSKDAHYVKAIRAIKETASTWGDTGDQLLAAAVRFADDFDGWTGFGVMRTHHDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P330</accession>
    <name>A0A0B1P330_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bacterial transferase hexapeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001879">
        <property type="protein sequence ID" value="KHJ32688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P330"/>
    <dbReference type="STRING" id="52586.A0A0B1P330"/>
    <dbReference type="HOGENOM" id="CLU_013964_0_0_1"/>
    <dbReference type="OMA" id="ACNNCIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="672" mass="73912" checksum="6F8316D9B5498E51" modified="2015-03-04" version="1">MEAGGGKKSPDSPISRFTAVNSFNDQKASLGSILSPDDSISGNDGSDRRNEEKCCSQKKPSHNHGNENLVAQTMNPLENRVTASTNCEEVTSRPSLLHFVPETSRKRRRSSLISNNPYHIAKAPDTSAGQKPPTSPAGLDFAQECLPSHRNVDSRDNFPSDIQYRQYLSPNENHGLIHATGAWSNTRQPHPQRSLTLGEQIGRVLQIESHNINAKTIQQEITKQSSENNQTQNIKPQPEVKKRKRNFSNRTKTGCMTCRRRKKKCDETRPKCNNCVRGGFTCTGYQTHDSSPKAGKKAVSLSLQSKKERENSLYASADSISSISIAGFQPRRSLPGYCDPALKADSRHDQILGGEGHEPILCNYSTAQIPSLAIAPSSSYLGQHIQCLHERKKPTQNSSRQESGVSDDPEKSVSATPSSSLPQLLHSHEHGTTTLSNPQKAAQLALSTITSVSRPCLSDEKFQTERPTQKEKMLAGQLYYPLDKELVQDRKRCKVACWRFNNSVNPNLGVSPDERARLFRDIVYPRHVGDGFVVEAPFSCDYGYNISIGSDVQIGKNCTILDVCEVKIGNRCHIGPNVDIYTASLPIEPKIRLGTNGPQFGKKVTIKDDCWICGRVLILPGLTIGEGSVVGAGSVVTKDVPPYTLVRGSPAHVLRAISRNESKLDLSMELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P337</accession>
    <name>A0A0B1P337_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003005">
        <property type="protein sequence ID" value="KHJ31311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P337"/>
    <dbReference type="STRING" id="52586.A0A0B1P337"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="OMA" id="FKMESAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="24541" checksum="2CA91E91626F4D75" modified="2015-03-04" version="1">MKVPVERHGQALKWLLQFIRSTLKQKLRFGPGDIHSETMGIYSDADWASDKRDRKSISGGVAIFYGGPFAWASRKQTSVSTSSTESEYIALSMFAKVGQWAAQVWKDLGVPHYINSNRERTVQMFGDNQGALALVKNPHIHERSKHINVSYHDIRDLTEKKKLIVSYIPTDSMTADGMTKPLARVAHRRFREQMGVVDEDTLQPLTGKTVKTFSEGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K0</accession>
    <name>A0A0B1P3K0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cellular morphogenesis regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P3K0"/>
    <dbReference type="HOGENOM" id="CLU_001197_1_0_1"/>
    <dbReference type="OMA" id="GLETCIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="387"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1375"/>
            <end position="1843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1870" mass="211124" checksum="137907CB40802522" modified="2015-03-04" version="1">MASERSVTPEPSSGRASPVVKTWSSQLSVEEVPLKDKAFRRYASSVDRSLSLFESALQEWADYISFLSKLLKSLQARPPHSNEIPHKVTVAKRLAQCLNPSLPSGVHQKVLEVYRFIFSIIGKDKLSRDLYIYLPGLVSTLSFASLSVRALFIELIEDFFLKVDPQSLRPAIKALILALLPGLEDETSEDFERTLHLIDNFKNVIRPANSEDLMNGHSSGDGFFWQCFFLASITSSNRRGGALAYLIRNLPKLGQSLPPISPSLGTTTLNIEQGASSHRFSEILTSPEPGLLLRCFAAGLNDEQLLTQRGFLDLLVTHLPLHSTVLQKKVKSEDLELLVTAAAGVVSRRDMSLNRRLWTWFLGPSVDIDNGIALGEQLQQSISKTQYFEKFGLHPLTQALLRLIEHNSDSPLERARPFKICLSLMDKWEIGGLLVTEIFLPIVHSVYKYKTQAATKTEFSEVLRSASVFFDGVEGGLIWSEIMKLITQAISPGKFSYLQRHEKLSLANFIITQFNVREEEMLMVHAPLTVLAILLILEDSREAPHIDLLDPKTFEELSNLALELAIDLVEFIPERALQNQPSTVHEKSMTHERPSHENILEANILQNIKDFYIQEQGNLDASPPPFTSIRVTELLLQKAAAFTTYKLSTLSSAHEVSNIAWLLVNLLSKATQVESFDTSKLLSAMTNRLSASSHLPFLVFTSINYLATSLHSSSYISMEDLSGLVELLVRRAWLYMSASYPKYHVEAVRSLWQLQAALSSSNRDIEAAICSIMIENGLNDSQNARYTEFGRTFSVLWTHTLYDNPTNVDRRSSKVSRLENKSEIRFSSADHFELILSRPLFLLLDALSDESTQLFMTVRMWLQNLTNTHKLFHIFVTKLSQFDFLQNIPIDLSGVSNDQRLIHRGDYDLDQCLYYLRTLSNVLRWASESTWATLALNNIPSEIVITMKLAEKDSETTILGFFLDICLKVIRITYDPDNIFLQPQVSHLHRTSLNLLHQILLCPYTLSLADLRLEKILMERLMQSLDEPDPFVQVLLLDVVFATLKLLNKPRHEPPLSSMLSIKRSFTSVQKTSSNSQPSIISENTDSIESSHPNLPPILIKCIQAGLSAASSRPVLDSWISFLTECLQFYNEDIFQILIPLVETLCSQINDTFSSLQNIFRKNAQDTIKTYAPESTLISLLNGLENVLERGHHLLLQDESRTPNIKSPDQPQGFFGNIVSGVFASDVPQSRSATANNRLTVLLTFQDAVKICYIIWSWGGDEFSAQDSNSTSSFKYTSLRMRNRARRLLEHMFAVEAFECLETMVELWRKSLTSANCLEPSAFFNLLHVLDGSRPKYTIPAIFNSIYSRTNPSALEPDRKSTLTSSLSDVDLTVFLIEYCKTLEDDAMDEIWDDCMRFLKDLLSNPFPHRQVLPRLLEFASILGEKVDNTNFGEQWKMRRELGDLFIRLLIAVFTTRPIGFLESLVKSEEQDSSQVSRLLRSEDVVAILAGIAPKLPKILVEPDRIISAANTICSNVIGPTFKSKLFPECVTKNTLELLNHIAKLPQNQRLWKKDLGEAFNDHKFFTSPITLVDSGWLPLLKQWSLNDKERMPEYLSRLVPPTTAGLFGVGATSTRNEADRKAQLNLRRITTLVLATTDDNFVKDLPLIQEKIVELLSATATSSPSSITRAEIYLLLRSLVLKISTTHLASFWPIVNAELRSAISSIIAPDHSPASDTYNNYSILQACKLLDTLLCIAPDDFQLHEWLFITDTIDAVYRPLEFNSVALIDQISEELELNPVSSSVPIDMDVLNPKNSLTRRPLLDMKGANDTIVWEKKDVLVGRVLRPFFSQLSIFFFEGIYSMCLPDREACRKGLLEDLFDDRSIVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3N1</accession>
    <name>A0A0B1P3N1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5414</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002788">
        <property type="protein sequence ID" value="KHJ31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3N1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3N1"/>
    <dbReference type="HOGENOM" id="CLU_007736_0_0_1"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000666">
        <property type="entry name" value="DNA repair and transcription protein (Xab2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="12">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="13">
        <location>
            <begin position="325"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="700" mass="81746" checksum="7111EA8DC9422BFE" modified="2015-03-04" version="1">MYLTLRIKHLGKINSARYFSEYEKINSLFERALILLNKMPKIWEMYLSFLLLQPLVTTTRKTFDRALRALPLTQHNRIWALYLPFANSAEGDTAVKIWRRYLQIHPEDTEEFIDLLIKTGYHTEAVKNYIVILNNPKFKSKNGKGLFQLWSDMVDLLISHAKEIQTGDEIGIDVERIIKSGIDRFADQRGKLWTGLATYWITMGNFEKARDVYEEGITSVMTVRDFTMIFDSYVEFEEVITSTLMDEAAIRSEQGIEDENANFDLDIRMIRFEQLMDRRPFLINDVLLRQNPNNVSEWNVRIGLWGNNKTEIVKTYTDAISSIQPKKATGRFHELWADYAKFYEKGGDIHTARLIMEKAVKVPFKTVAELADMWIEWAEMELRNENFDEAVKIMAKAVQAPKRSTVDYFDETLSPQQRVHKSWKLWSFYVDLVESVSTLSETRKIYERIFELRIATPQTVVNYANLLEENHYYEESFKIYERGLDLFSYPVAFELWNLYLTKVVDRKVSIERLRDLFEQAVEGVPPKFAKVLYLMYGNLEEERGLARHAMRIYERATRAVSDEDRADMFNLYITKSASNFGLPSTRPIYERAITALTDKDARDMCLKFADMEKRLGEIDRARAIYGHASQFCDPRTSPGFWVKWESFEVQHGNEDTFKEMLRIKRSVQAAFNTDVGFIASQALARVEAVSSNKPENEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3S0</accession>
    <name>A0A0B1P3S0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001718">
        <property type="protein sequence ID" value="KHJ32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3S0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3S0"/>
    <dbReference type="HOGENOM" id="CLU_023878_1_1_1"/>
    <dbReference type="OMA" id="KQEARPK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="414" mass="46872" checksum="57A483B911E76A14" modified="2015-03-04" version="1">MSESKTSPQLNQTCPKPLKRHRQKLLKEPSLYFTSKYWDRLPRPHLTKNALKELNYRNRQLESPISTPQTYPELSPDLLEALRQIAREGGPDLTDLRGFPEPFDDTMESYEQGQSSRSTLWTRPSGTVRKTKTTGPYDRDFASILEASGIYSDPYIGPEKPFSIVPTNINEMIERADQPRASVSAETYQESRFQKFRRVIAYANFETEVVASVVPTLEAENGSEKLENSNITFSNLAPLIDGGLDHIVLSKTSPDLFYGSSFECLDERIRQNLSSQVLPKLDIEKPIAPNFFLELKGPEGHQRVADRQALYNGALGERGQIALRSWGHDHPVLDGAAHTITCTFISGALTFYSIHAVPVETPSRRIEYFMYLIGIYVMHASASQYRKGIAAYQNLREYAEEKRNESISLANSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P475</accession>
    <name>A0A0B1P475_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002306">
        <property type="protein sequence ID" value="KHJ32135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P475"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="35997" checksum="E20A1536DCE040A2" modified="2015-03-04" version="1">MVQKINMQEVNRNKESQKVSHRDNSATSMSDKRLFVRLPQGHEWRKLSPADIREVIVKKLHISPSLIGRIKPVHSGFALSPCSAEAREEILKAENGLFLTGAKLETATNWVSVLVPTVPAFVKMEQGVVEVSKDMLSDEIERVSSMRPAHLKLYGRNNLEAPHRTWLAYFPKAPREGFRVFDESGVVRPYKKQKPIEFCKRCNRHHPSKNCSRAPSCANCGSTNHTADICMAATKCRNCGGPHRADSRRCLARPTRSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGSQASEVSMTIDNSQATPVDNTTAVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E3</accession>
    <name>A0A0B1P4E3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002809">
        <property type="protein sequence ID" value="KHJ31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4E3"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="134" mass="14524" checksum="5CA049BD38DD14AB" modified="2015-03-04" version="1">MAFKAFLRQAIANFAAANSSPAPPLISSHTRPNKGKGNPNNKDKKSNKALIATPHIVPTPVLNRRKTHEVALPKTPPTNNNTWGTVARNSHKKASVVVGEKTHAFPLTKAAQRQSSMDKIATSGSDKRLFVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4F4</accession>
    <name>A0A0B1P4F4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative choline kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002785">
        <property type="protein sequence ID" value="KHJ31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4F4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4F4"/>
    <dbReference type="HOGENOM" id="CLU_012712_4_1_1"/>
    <dbReference type="OMA" id="CEQVINW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="597" mass="68875" checksum="D666F5C37AB2F776" modified="2015-03-04" version="1">MADLPLRPVPTPKQSYSKDKSGRGEQPYSDHSSFDSYHKVKNEVVPFCDVYLDNSNTISLLLRPTDPTPSNYSLDLKSKPDKNLTHWIDFKTEILKLAQNLKLDGWQNIPVECAQHIGVERVSGALTNAVYVISQPTFLRSISSGHEDQHAKNSSDKALLRIYGHQFNQLIDRENELRILKRLAQKNIGPKVLGTFKNGRFEEYFHAKTLGAEDIRNIDTSKQIAKRMRELHDGVELLEQERNEGPFVWRNWDKWIDRCEEIMKILDDSVRTHEQHGILRNWKTRGFVCGVEWPQFKSAAEKYRKWLNDYCGKENIRQNLVFAHNDTQYGNILRLLPENHVASFTPPPLLPDNTYKNLVFIDFEYASANTPGLELANHFSEWCYNYHSPTKPWLCDTKKYPSLEEQKVFITSYVTHRSQFNPRMPIISEVNNLKRSYNFGLSNSQDRSDSVTNLGCSTINQESLLQEPLDELEVQKQVLELLEETRIWRAANSCQWIIWGIVQAQIPELFNTSTTHNLDRTVEAGIAAIPTSCTGTIEQTTEPFDNAEVTEHDEGYDYLSYALDRALFFWGDLLSLGIVSKEELPSELIERIKFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q8</accession>
    <name>A0A0B1P4Q8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01001289">
        <property type="protein sequence ID" value="KHJ33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Q8"/>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="OMA" id="MCRSEYR"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="23164" checksum="E0C4706C720746F2" modified="2015-03-04" version="1">MATLFKNYDNLIDFNRQSLALLKDFYRNNNLYLSEYRTKFLTRLAGGNGRLACYGLGVTIFSLGIFRDFLFERAIREQSTSLLLSTPLFRALSYILLAIGNTLVLSSMWALGFTGTYLGDYFGILKENMVTGFPFNITDAPMYYGSTLSFLGTSIYYGKPAGIILTLEILIVYLIALRFEDPFTMEIYAKRDRERKREKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4T6</accession>
    <name>A0A0B1P4T6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002177">
        <property type="protein sequence ID" value="KHJ32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4T6"/>
    <dbReference type="HOGENOM" id="CLU_038480_0_0_1"/>
    <dbReference type="OMA" id="ENEHYNI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="60240" checksum="E725DF891977EAB3" modified="2015-03-04" version="1">MSSDPQSQLSAAFQQSWPNLSSAIEGHQFPDDSNPTPLLTSIASTIDTPEKNMFCSLLLCFDSKFGVLKSQLELKGKKVSKLNSDLGAAQRQVEELRTALSHAHKEIAVILDRSTDNDKISFLNDKISSLQSEVNTLQATFNAKGISTSKTADVATSIPRRTRSDPEKFSGAQKDTEKRQIMYESWKTQVQQVLLVDGGCFLDSFNLISYITSQLTGKAWMAVQDGVRTLNSHPNDPQKWPWRTSIDLWDTLDRRYILLDSTQTAKNALDTLYQDKSAYRDFKADFDHYAERARYDNRSKVDLLRKRLNKKITSVIDNQVNLPNADDYAGWSEMINSIARNLQQQEHVAKLQTPSITRPSDPHVISTAPELEDPMPMDLSRMRLSASERTYRLENGLCVACGEKGHIAKDHHRKINPIPMPKRHNNQPTPRREDNLYRAPISNKNNPPNPRNTPLHYTQPLPVPMAYYPSQFFPQQLPQNFQPSYFQAQTQAQLRAMDEPYDSGNDVRSETPSNDNSVSVKYNQLKDQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V4</accession>
    <name>A0A0B1P4V4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative snare complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4V4"/>
    <dbReference type="HOGENOM" id="CLU_053570_0_0_1"/>
    <dbReference type="OMA" id="QIHAYHS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="276" mass="31455" checksum="2F6108B862416EA3" modified="2015-03-04" version="1">MANFNQYFLLADHIKLSLLERQVAIHSNTKSASQDSYLSSLLESLREGIEKINIEQSRLENLGDKDASQTIQEIQKNLQAQYDDFITKFRDITPTKVMSNSLHINDAVSSGHVMETPERSLIGLSTKSLKTSIRGSPNTPITSKTVRFSDSPQRTNSSLFFPYRDEPNSIDGSQFDNQQLLSYHSRIMNQQDQALDNLSKSIQRQRELSIQIGGELHEQVEILDGIDENVDRHQTRLRQTMKQLETTARNVKNSKQIKIIAILITILVILIIILNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P516</accession>
    <name>A0A0B1P516_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001488">
        <property type="protein sequence ID" value="KHJ33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P516"/>
    <dbReference type="STRING" id="52586.A0A0B1P516"/>
    <dbReference type="HOGENOM" id="CLU_014181_0_0_1"/>
    <dbReference type="OMA" id="QGMICED"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47811" checksum="AF8FCB09AF5D4AB9" modified="2015-03-04" version="1">MPPLILHHVPDDELYIGDDGVQRPFAMLFANNNETNNQITRPRRTVHETGSFGKSTRRSRSRAGTPAAKREDPTLTAADAIFSHFIAQKAAESSELPQRPPSLLAPGSQPSLINTSVTQNDGIGLISKFPKHRMKEPTEVILRGFKSSQQYAAIREYERIAGRICEDYPRDPPIEQRKYKIDSGDPATFRLNPLTADEKAKVYKFAGGHHWIKVTFESAETAEAAIECSPQRILGHLVFAEPYRGTPPVDEEIFASSNPKDYESQKFGVYSKSSNKTDSQDQYPNRLQNLDPSFSSSITHGFSHGPSSISKSTLEDFAPTTVAVSSNTSETSAACSGSNSSSATGNFCQRIPTAKRLKLLPAEDALLPQKSPIEKFLGSLPFIGWVSKDIIGGAIPRTELGEFDYVNASLYWKLVWFIERITGIALLDDTKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P557</accession>
    <name>A0A0B1P557_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001454">
        <property type="protein sequence ID" value="KHJ33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P557"/>
    <dbReference type="STRING" id="52586.A0A0B1P557"/>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="662"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="930" mass="104814" checksum="4C44F496A4840D2F" modified="2015-03-04" version="1">MATSAAAGFLGRGTSSNHSNMRGLVQFIADLRNARARELEEKRINKELANIRWKSQCIRKDLEDHNELFNCLALNAIANVGGREMGEALSNEVHRLLISPTSKSFVKKKAALTLLRLYRRHPDIVQPQWAERIISLMDDIDMGVALSVTSLVMALAQDHPDLYKGSYVKAASRMKRILIDNEYASDYLYYRVPCPWIQVKFLRLLQYYPASEDSHIRDLIRESLQKILNLALEMPKNVQQNNAQNAVLFEAINLIIHLDTEQALMEQISHRLGKFIQSRETNVRYLGLEAMTHLAARAETLDPIKQHQSIILSSLKDRDISVRRKGLDLLYSMCDQSNAQPIVGELLLYLQNADFAIREEMVLKIAILTEKYATDVQWYVDITLRLISMAGDHVSDAVWHRIIQIITNNEDLQVYAAQNVLQFIKTDFCHETLVKIGGYILGEFGHLIAEDPNCSPIEQFMALQSKLHGCTSSTKAIILSSFIKFVNLFPEIKPRLLCVFKAYSHTLDPELQQRACEYLALASLPTDDLLRTVCDEMPPFPERQSVLLSRLYGKNGATSDKRTWVVGGKDANVNTNEKDFTLAKNPDSQCLNRATTFSHTSNGKKDPPNDVSSGHRSGADDLAGLDMTDARQSSNKNAKTSYASVNMATAAHLSPNWEIGYNKLLVDTEGILYEDGQIQIGIRSEYRGQMACVIIYFSNKAPSALTSFTTTFDLDPSEKNNLTWEMKGLPETTLYSGSQSQQMIMFEAKRIFEKSPTVRISYLAGALQALTLKLPITAHKFMEPAELSSDDFFKRWKQIGGAPREAQRIFGLKNGKDKDRVFTDSFIRKTAEGFRWGILDGVDPNKNNIVGASVLHTSECGKFGCLLRLEPNYGTQMIRLTIRATDESVLWPILKYMEQLLALGASTLPESPEKPTKRETNDTFRNAMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5C3</accession>
    <name>A0A0B1P5C3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5C3"/>
    <dbReference type="HOGENOM" id="CLU_058677_2_0_1"/>
    <dbReference type="OMA" id="VTIMEPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="206" mass="22729" checksum="1019FB31593F6D9A" modified="2015-03-04" version="1">MSNNPNDSRRRRSSVVPIPMNSIFPRANCPPFPGPITIAAAQDQHRRLSITALGMPSHSPSKTSTFPCDDRRGSTTSSLGYTTTEENMFDEDDNGRNIPTTPLGRRMSLGAQAIRSARGGHSPGSFGEGNYFSFPEHFRLRAESSVTQSQKPHFSGSSNSARNNAALHTQTEMRPQSVDSPAPIRAQEKRPDAFQERMLKGDFYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J0</accession>
    <name>A0A0B1P5J0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001134">
        <property type="protein sequence ID" value="KHJ33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5J0"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="574" mass="63541" checksum="D8EAFCC5EA23EE62" modified="2015-03-04" version="1">MNTVEENSALSMDSSPLPTPTPPIPQLTHPPDPFNSSQPSQPPSTSIPLNTTVANRQIREPVPPSKRTLTEISHNDIGEEMSNVSKFIPQELAEIFAIRQRRERAWHARILICTSVISNIDSTLADFKDEISREEATAFQVYLRQAISKFAAHDSLPTPTPPPIPSKSFQKKQSEIPNPKLPNKPIVVATPIMIPTSTAFHDPTHVTQLRENSTTQSTWATVTRNGQKKTRVTKANNTKSTQAKKANHVERLNEPRALSNLPRRQALEGKSTPPGNVDKRIFLRLPQEHEWRNLSPAGIREIVVKKLAISIATIGRIKPVNTGFALSPCSNDAREKILEAQHGLFMSGAKLEPATNWVSVIVPTVPTYIRTLLGKIEVNKIMLADEIERVSSVRPSFLKLYGHNNPAAPHRTWMALFAKAPKPGFRVFDESGLVMIHKKKKPLAFCKRCNGHHPSKNCSRASSCGNCGSTMHTEDICMAVTKCKNCGGPHRSDSRRCLARPTRSGIPTKEQLKSYRQAGEREFQAVARVKEAELKAATAEESMLDLDSSQKTDSNSSETQASTVEDSTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5W1</accession>
    <name>A0A0B1P5W1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001301">
        <property type="protein sequence ID" value="KHJ33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5W1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5W1"/>
    <dbReference type="HOGENOM" id="CLU_1548759_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19452" checksum="DD388E66610B55D8" modified="2015-03-04" version="1">MWPDGSAAPILGPIEQCNDYERGIPGFTGCIRGYSESISGSREITGQPSAIATVRPHGMIKTHSNSSLQLRKNLASRVAPRRVSIPTTQTQVIHQRSAKDEFLIQKRRAGMSYKDIRLEGGYTEAESTLRGRFRTLTKPKSARVRKPEWSDKDVSLRYLEITLLGLDDWANFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Y1</accession>
    <name>A0A0B1P5Y1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002189">
        <property type="protein sequence ID" value="KHJ32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Y1"/>
    <dbReference type="HOGENOM" id="CLU_1741921_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="150" mass="17072" checksum="5823F253A197608D" modified="2015-03-04" version="1">MPYGITRFRCTVVKPYYHNSDQLIPENKDIDNDNRSVAEDTQGCDFDLTPSDSQQGLLVKRGRGRPKGTRNQPKLDKVRQIWEINGKEKDHPYEKTRLVIQAYDDQAGKVEIFTFTRCRCKSPACSACLGWPGRFAQSFPSGSPIHHRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P604</accession>
    <name>A0A0B1P604_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001840">
        <property type="protein sequence ID" value="KHJ32750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P604"/>
    <dbReference type="STRING" id="52586.A0A0B1P604"/>
    <dbReference type="HOGENOM" id="CLU_035429_0_1_1"/>
    <dbReference type="OMA" id="PSTHHMS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="387" mass="43348" checksum="AC711EA88B9B840E" modified="2015-03-04" version="1">MILSPIRRVALTVQYISKTSKLPGSLLRVVTVNSNPSCVPCNQKRASSSKPPSPTNGSKGVTEDRPVTSTRTEASSVEAKPLTTKKKVKGAAVKNMLRSKIQTTFNIPSVPSTQHIKPSLLGPAAFFSLHRPISITNGFPQPVTDEDFASIFAPRTRSTKPQEVILALSSTLDSLNAVRESLDTLSSESQQNQWAEIDETDAVKNESILQSPEIQRLQVNQILGIPQYFMSGKYTPFNPPQPPQPHGIIQTLNKGQTEARKTRYKIYTAVLTVEESTDSNGDVTLKAHHSPLAAEEQYQVPIRSHGRLKTYPARYRMTRSLIAEKLAISVKRQRKLKMKKHKYKKLMRKTRNLRRRLDLSLMQKETLSSPDTFPDTFSYNTDSLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P617</accession>
    <name>A0A0B1P617_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative stress activated map kinase interacting protein sin1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002321">
        <property type="protein sequence ID" value="KHJ32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P617"/>
    <dbReference type="STRING" id="52586.A0A0B1P617"/>
    <dbReference type="HOGENOM" id="CLU_005130_0_0_1"/>
    <dbReference type="OMA" id="PFQKFAH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="332"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="704"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="812" mass="90042" checksum="2B2A6C9C95725D87" modified="2015-03-04" version="1">MSIIQVEDLVSYQLRTNYLETISDGVGERLININNTCFNTAGFRAAGWRQIAANKLRTHSPPIPTAIASEYFQGPSKFKNKNLVSLDDHVQEENSSASRTAAIIDEIGVVTKRKSRQEQIQEEDSSDISDESDDETEQASTQRIKFSKMPIRRRSGSSPIRGSNLRLSSTITPHSNTPATQERRESQPLIGISIARMRTDTITSSEISSDNEFDASAFHRQRDAVRNIARSSMFLNQSSDSNVTLKEPINCLIEGEAEEDSDDSGLDSDFSGSLDSASIIPGLDSPINASPIDVVENLPRTTPKSPNKKSKPVSAILTALPPARPISTIQPKSLLSAAIKAKKTKASMPFESYASLSGQAESNPLNLRIWAPFSTSPTNRFEVLIRRNVQENGIGDRQVTVVDLIGLSLWKYGEEKLEPNLPEEKLNINRWTLRLVEDEEVDYDFPALDRAKPVVAFSTANNRAARSRSGSKPYDEFALVEATDEEFAENQKIPSHFNQESAVQATDSTLNTTKQSNFSSPSFTTITSIQPRLNPDLASKFVLRGNGTHADTLPVGAATTDLPSRSGAQKFLHIHIYSGDAGPRQMVTLDVTTDTYLVDVLDIICKKRQLDKAAHVLKISGTGTLVLLDRTVDSIGNRTDLDLTRRRFATDGPLTMTGSPSSSSPKASWFLERPDSRKFKKSNIMGSHPLAQHSMKQDEVGSANYRKYIVWRKQPMRFVGMNERLLVIDGEYLHIMPASTGKTLFDGQGKTTTVHFSNIVGCKITRRHPSNFKVVIFRQTETKRYDFEAKNSDEAAEIVFEINKGISPYYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F7</accession>
    <name>A0A0B1P6F7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001999">
        <property type="protein sequence ID" value="KHJ32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F7"/>
    <dbReference type="SMR" id="A0A0B1P6F7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F7"/>
    <dbReference type="MEROPS" id="S10.008"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="AAPYVWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005110164" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="474" mass="53155" checksum="512B812232D875C2" modified="2015-03-04" version="1">MFIYSLLFILLSLSVNAKTFSAHLNDKRSSYKENEVIRTIFKHDATGATIDYVTNSGICETTPGVNQYSGYLSVGTNENMWFWFFEARNRPTTAPLSVWFNGGPGCSSMVGLFQENGPCHFENGSDEPSLNPYSWNEYSNMLYIDQPIGVGFSYGENNVNSTTSSAVLVWKLVQAFYAQFPQYENRTFGVFTESYGGHYGPEFVSYFQSQNMAIKDGRIKAQVIDVKVLAINNGWYDSAIQTKALIDYAYKNNYRPLINSTEYNEYIDVYNKHCLPALQNCTSKVGQDASCAFAFDTCSNYVEGPILNTKDFGIYDVRAPRDDPNPITTYLKYLNSSQVVNAIGAKVSYTECANDLFEKFSETGDNARSYISTLSSVVQSGVKTLIWAGDADWICNWYGGLDVAQNINYSESTNFKTQKSANYTINGKVGGEFKTAGNLSWLRVYGGGHEVPYYQPELALQVFRQMFELGILNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G6</accession>
    <name>A0A0B1P6G6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001995">
        <property type="protein sequence ID" value="KHJ32546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G6"/>
    <dbReference type="HOGENOM" id="CLU_012348_7_1_1"/>
    <dbReference type="OMA" id="AWPCSNL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="10">
        <location>
            <begin position="44"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="11">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="665" mass="75361" checksum="4D72BFE5E45E60EC" modified="2015-03-04" version="1">MSSPQFQFSSPISTTGGRLKKSRYTYRNLTQLSQSVTNCPLRVIAHVDLDAFYAQCEMVRLNVPENKPLAVQQWQGLIAINYAAREFGLSRHVNVVEAKKLCPDLILQHVPTWKEGHEKWAYHDDASRNMATHKVSLDPYRLESRRIISCIKDHLPVDLQKVEKASVDEVFLDLSAQVHSTLLDRYPELAGPPPYDDPTEFLPPPPSTALDWKADALVDLSSGETEDDDPDWDDIAILIGSEIIRDLRAKIFKALKYKCSAGIAQNKMLAKLGSGHKKPNQQTVIRNRAICNFLSKLKFLKIRGLGGKLGEQITSKFNTDTVEQLLLVSIEQLKLKLGCETGVRVYQFIRGIDLSEVNFRTQIKSMLSAKSFRPSIKTPEQAYPWLRIFAADIHSRLVEEGVLEFKRRPKTMNLHYRQGIQNRSRSCSLPLGKRLDEIGIFEISKNLLNQVVEDGQIWPCTNLSLSIGGFEDGVMGNMKIGAFLVKGKDAMAMFSGNSKSESINHDHSEKRRRLETSTDIQNYFQRQLNDAVDTKDQRNLSLDAIHKNCAIDSDNEKSIFLKSKLHHENTESEVRLNDENLHDVGNKSDLICTRCKEQLDSPNALQSHQDWHLAQELHNEERTKVLLLAKSSKPIVSKNAWTSSKKRKNAENIKKIQGQSTLKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K3</accession>
    <name>A0A0B1P6K3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000959">
        <property type="protein sequence ID" value="KHJ34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K3"/>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="OMA" id="WNYLDAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="527" mass="59901" checksum="648849318715C4BA" modified="2015-03-04" version="1">MGSAERKDLKFSMVISSFQSSFQRHVPSVKFFRLTASNLLYLFSSSYTTKTPTNLEYLTGIMSSSISSESHKGSLYSTKTSSSDNSLEEPENKTGKSTDDSSKLRLFMGILKKFVGVADIATVRFSLPAQLLEPTPNLEYWNYIDQPSVFAAIGLSNDPVERMLEVLRFWFTKDLKYVKGKPCKPYNSTLGEFFRCNWEVNNEIPTIAELKKIGEGSRSSSRSKFSRNSSTSTTVSKSFSISPISDKIKVSFLTEQTSHHPPVSAFIVDCPERGLQARGFDQITAKFTGMSVKVSPGEHNFGFYITLKDRDDEEYHLTHPTAHIGGLIRGNLNVTVCEQCYITCKKTQIKTILHYVEESWLGKSQNKVEGVIFKYNPSNDVIMKIKDVPESDILGRISGAWKETVYFSLGSSNKHRIPLVDLTPLYPAEKIVPPMTFQLPNESRRQWYPVTEAIDERQYSKATSLKLELEEKQRMKVKEREQKDTKWTPRFFVGALTPEGRPELTSEGKEVLLHLQKNEWKLEEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N6</accession>
    <name>A0A0B1P6N6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001142">
        <property type="protein sequence ID" value="KHJ33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N6"/>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="OMA" id="MMTTSWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="124"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="426" mass="48811" checksum="C21E330C85C610E8" modified="2015-03-04" version="1">MEWLGLARTRFTHSQDTIKLKKNDGQETDLLTICQDSTPPCKLNPIMFNGHLQTMWTAVKKEGPAIHYKRKIFESNDPAFEGSFAVDFVASPSNKIDDTLPPRTTYYSDQEFEDMKLEFDNNRPMLVVLHGLTGGSYEIYLKHVLEPLVNAEREWKWDACVINSRGCARHKISSSILYNARATWDCRQTVLWLRKTFPKKQLFGIGFSLGANILTNYVAEEGPTCKFKAVVVISNPWALEISSVALQKTWIGREVYSKTMGGNLKRLLELHYDQVSKNSKLDFEKIRKAVYIHEFDRLVQGPTWGYPTEGAYYRDASSVDSLFAVKIPFFAINAEDDPIVTNDAIPYEEIKQIPNAVLCTTSLGGHLSWYEVGGNQWHARPAVNFFNKMAFEIKSEISEVIPWEGNNKSDHGVKKFDPMRRKWRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Q2</accession>
    <name>A0A0B1P6Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative et-dependent rrna methyltransferase spb-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Q2"/>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="OMA" id="QRKDKYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="622"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="834" mass="94470" checksum="4DDF591B4FD36482" modified="2015-03-04" version="1">MGLQKKHGKGRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLERSKVLLDLCAAPGSWCQVAAESMPTGSLIVGVDLSPIKAIPKVITFQGDITTDKCRATIKSYFKTWKADTVLHDGAPNVGTAWVQDSFNQAELALQAMKLATDFLVEGGTFVTKVFRSKDYNSLLWVFNQLFNKVESTKPPSSRNVSAEIFVVCRGFKAPKRIDPKFLDPRSVFAELSDPTPNNEAKVFNPEVKKRKRDGYEEGNYTQFKEELVSEFIKTTDPIAMLGSLNRLSFEQPSNGDIALAALDRLPETTKEIRDCCMDLRVLGRKEFRNLLKWRLKVREKFGLVSAKSKVLANDGDEAVAVEPMDEELKILEELQSLSEKEKAQRKRERRRENEKKQKEIIRMQLNMTVPTEIGLEQSGPIDEGSVFSIKTVDKSGAMSKIAKGKMVSITKKGQDEDIENEIGSDSGTEESDDEQDKLDRELDKLYEQFQERKSQSNFKHRAKKARQEPEDGVWEGFSEDNVSSDDENLKEDSSDEDSDEDDPKTQDPLLTNLKNDMAKTSSGLSRRAAQFFSQDIFKEIGGISEEVDFESDVETEESSSESVKKNTETTEGELVESSEPDINEQYASAFESSEEDKDFEVVKKHVEETEWEEEPSKNGRLDIDIITAEAMTLAHQIASGEKTKYDLIDEGWNKNSFKDRDGLPDWFLDDESKHDKPHRPISAAAANAIKEKLRALNARPIKKVREAKSRKKFKAAQRLEKLRKKSALLQDEEGMTEKEKAQSIVKLMSKAAKKKPRQKVKLVVARGGNRGISGRPRGVKGKYKIVDARLKKDTRAEKRIAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T4</accession>
    <name>A0A0B1P6T4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001642">
        <property type="protein sequence ID" value="KHJ33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T4"/>
    <dbReference type="HOGENOM" id="CLU_024466_2_0_1"/>
    <dbReference type="OMA" id="VILNCWP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="62361" checksum="7022C0D50D74F82C" modified="2015-03-04" version="1">MFTAALHEAQKCVRSAQYIDVILSPQFLPSTYSITAISKEVLPKEPPEDLLEKHKIILLINTCLSQVGRLSRQPTPILHTDNGEDNNEITAILRIIFTASKIIRPNGNLFLSDKLSNAEKQTALDRIRHIGELGLSSIFCLHSLLPEDHKNEFEDHIIISLLAFTSASDPWTTKVSLDLANRLLSIFRIEILKQEFIMNSVLSSFIRPLFSSSKPKAITTSGYAAISSYTPREPYDFGAWNLTSKPWRLDNCYSLSILSWVVNQASQEVILSVFHLLIPPILILLDSPNAEMQFKGLKILDAFVQKLTPKLLEQTGLGAVIEDAIHPILLYLPPITPLNESLSLLPAAFNSFFVLLEVRFSSSTSNDIRRQDQAKQKLTSLTRLLRQAIAPAYNHTSMSSDSDPIIKKIILAQIPPLVRALGVHSIAHLQTLLQIAEDSLLDPFATDSLPTMLAAIKALKEIVLCAWPRLSEERRRRELIRMMVSAWRKIYDDKNNSTEAFKKETLEELKSLGRIFVRAVESSDDLDLSYDLNPLIHIDETLKDLFGVRIDVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6U8</accession>
    <name>A0A0B1P6U8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c6 zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001117">
        <property type="protein sequence ID" value="KHJ33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6U8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6U8"/>
    <dbReference type="HOGENOM" id="CLU_018979_2_0_1"/>
    <dbReference type="OMA" id="CPLVGSM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="557" mass="63616" checksum="DE3248BA7911A452" modified="2015-03-04" version="1">MAGPGGGPPRRSHTKSRKGCDTCKRRHIRCDENFPQCRNCTKHNCRCPYMDVTGILPPNLERSISPERADLKWTPKIEEEIVHWQRTGIFPFPDLLDFPETFPQHFSFEDLRLFYHIASISIELGQYNANKFTLWTRQIPLFLKIGINHGFVMHALLAIAATHLSWLTKCSLAASMAYEHRGIAMTGLHEAIGSFSRNNSDAILAASILLSWQENDWRGWMQLIQGTSSVIDAMNPWKDYSEFGEFLADQSTFPITPSPSYPSAKNSQLKKKDFYTLQQAYLQLQRLNLFFEDKDQIFREAIKKLMEFLLNIQRVSSKYTPAQLFETLDPLRTWLFWQPVMFLQQTKRSPLALVTIAHYYAIALVIEPLFPEVGAAYFGSLTLMPIEEIARQLISSSSYQSPGNLTSSLIDMIKYPLEMAARFKDQMEWLQPKKPLPLPPLSYHRNRTNGVKNIPAPLSFLPPSNSKYNYDQEQGQSTPAELLPATPSSLEPLSSPYFAMSSHMHEVFYSPASSNFGGDLGFYSNDSEAEFPHFDGDEYSSCDNFDEYAFPVTTVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6X6</accession>
    <name>A0A0B1P6X6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000870">
        <property type="protein sequence ID" value="KHJ34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6X6"/>
    <dbReference type="HOGENOM" id="CLU_2656303_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="76" mass="8768" checksum="A862A61E0AE392B1" modified="2015-03-04" version="1">MFSLIDQISILCTFIVFLIVACALCLCLGDRIEQRRIEGVLKLDEDRKERQKERELRGLLSWRDSIGVEGMGLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P712</accession>
    <name>A0A0B1P712_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001610">
        <property type="protein sequence ID" value="KHJ33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P712"/>
    <dbReference type="STRING" id="52586.A0A0B1P712"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="417" mass="45540" checksum="80025D232BC7CA68" modified="2015-03-04" version="1">MTDSMDITKETQAPSTEMGHKPPPIHPVPPIFNSPSPTAPFTPPSNSAMSNTTIDGRQILKPVAPPKRPITERPTSDSSDKSASRNAFFPKELADIIAIRQRRELARHARLLICTTIISSIDSALANFQDEIEKEEAVAFKAYLRQAIASFAATDSSPSPPRVPVHTRPNKGGGNSNGKGKDIDKISTKKVAVATPKIILTQGSNLGSSKEVELPRIIPSSDKSWVTVARKGQKKARITHNSHVVSGIKVVQKLSQKDKSASIISDKRLFVRLPLEHEWRKLSPAGIREVIVKKLLISPTLIGKIKPVNSGFALSPCSAEAREVILKAGNGFFLSGAKLETATNWVPVLIPTVPSSIHKEQGQVEVSSSMLSNEIERVCSMQPTYVKLYGQNKPDAPHRTWMAFFSKAPRCGFRVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P714</accession>
    <name>A0A0B1P714_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001082">
        <property type="protein sequence ID" value="KHJ34053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P714"/>
    <dbReference type="STRING" id="52586.A0A0B1P714"/>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="21886" checksum="298B3C0378FB5994" modified="2015-03-04" version="1">MAPAVSLFSVNAILILNTEDGSRVFTKYYNAPHNSNSNSTPNASPFGDIKAQKAFEKGLLEKTTKQTSDIILYDNRIVLYKCESDVMIYVIGGIDENEVMLYNVIIALRDSLHLLFKQTVDKRTVIENYDLVALTVDEIVDDGIILETDSTIIAQRVSKAPTQDVVQLKGIDLSEQGMNNLAQFGKAKLGDWLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C3</accession>
    <name>A0A0B1P7C3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative related to heatshock protein hsp150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001971">
        <property type="protein sequence ID" value="KHJ32579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7C3"/>
    <dbReference type="HOGENOM" id="CLU_081634_0_0_1"/>
    <dbReference type="OMA" id="RWYACET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080520" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="198" mass="21804" checksum="7877D411E3279F24" modified="2015-03-04" version="1">MHFSGLALVMFMASQLNAQENYSQTAPFNLVISAPGSQINGSYLASCHEGAAIEGLCVATYSKNSGSIYNLNYTSAEIADFVLGTVGLLTWVLHGVGFNLSSPMKLSYSATSNVAVPLFTPSEMGTMIGFDEEDKMFIPSFIDDTNANIQPFKELYYRWFICETYEGYKYTTLAWVLGKYSIPQNPTCQKVTVIKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7L3</accession>
    <name>A0A0B1P7L3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7L3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7L3"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="458" mass="49761" checksum="DA333B9AD199AFF5" modified="2015-03-04" version="1">MGKEKIHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGNGEFEAGISKDGQTREHALLAFTLGVKQLIVAINKMDTAKWAEDRFKEIIKETTNFIKKVGYNPKSVAFVPISGFNGDNMIEPSSNCPWYKGWSKETKAGSSTGKTLLEAIDSIDPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRIETGIIKAGMIVTFAPAGVTTEVKSVEMHHEQLTEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKNDPPKGAEHFTAQVIVLNHPGQIGAGYAPVLDCHTAHIACKFAELLEKIDRRTGKSIEATPKFVKSGDAAIVKMIPSKPMCVESFSSYPPLGRFAVRDMRQTVAVGVIKSVEKQEKAGKVTKAAVKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M7</accession>
    <name>A0A0B1P7M7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001703">
        <property type="protein sequence ID" value="KHJ32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7M7"/>
    <dbReference type="HOGENOM" id="CLU_1001823_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="278" mass="31393" checksum="E65D8E61FDD02EF3" modified="2015-03-04" version="1">MKEYNRRYQNLKEHTEISPDLKIQLKNLLLYHVSKIQPELVHNCRNLSYDETFAQCLQWTSSKASKFTIHKQSDIICNFCQNFGHIDKVCRKKIKAKHNSSCLAQQLKPLSFKSNLDQTYQLDTAADCHISGNSKDFSTYSISSEPIGVAGGGQVISTGRGDLIFPTSDGKIDNLKGAICIPGEKAIILSTAQLEKQGYSIWWPPNYQDIKLIRPMVLYVLSSNVNQVDLSGNLRLINKIPPNSIQFIATGIQFLAIRDRKHKTSPFNRLALKDINLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Q5</accession>
    <name>A0A0B1P7Q5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="JNVN01001482">
        <property type="protein sequence ID" value="KHJ33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Q5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Q5"/>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_1"/>
    <dbReference type="OMA" id="DSLINWD"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="125"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="25784" checksum="067BB0900CF2CE24" modified="2015-03-04" version="1">MSAILRNSMINSGRRARALGNHAFRANKIFARGKVTLPDLPYDYAALEPSISGHIMEIHHKNHHQTYVNNLNIFTEQLETAIAKQDVSKQTNLLSSIKFNGGGHMNHSLFWESLAPSNRGGGGEPAGKLKLAIEQTFKSFPDFKTSLNSALAGIQGSGWGWLLQNRQTGQLSISTYPNQDPVEPTFVPLLGIDAWEHAYYLQYQNRKVEYFSRIWDVINWKKVEERML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7V0</accession>
    <name>A0A0B1P7V0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative aureobasidin resistance protein aur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001433">
        <property type="protein sequence ID" value="KHJ33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7V0"/>
    <dbReference type="HOGENOM" id="CLU_030747_0_1_1"/>
    <dbReference type="OMA" id="WSIYDAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="418" mass="46931" checksum="0A290A3425D29B39" modified="2015-03-04" version="1">MLFSWLSFLNPIPRRYRRRLRSKFRSSISPTTNIAAVETSFNPRDTVRALRAHKWSAYDAKYLILIVITVFCLSVSRAPGPILKTGAASLLIAVLLIPVTRQFFLPVLPILTWVLFFFNARFIPAEYRPHIWVKVLPALENILYGANLSNILSAHQHSVLDLLAWIPYGILHFGGPFVWAALMFVCAPPGTVPVFAQTFGYLNIAGVAIQLIFPCSPPWYESMYGLAPANYSIKGSPAGLRRIDELFGVDLYTSSFTASPLVFGAFPSLHSGNAVLEAFFMSHCFPKLRLPVIIYAMWMWWATMYLSHHYAVDLVGGGMLAAIAFYIAKSKFLPRIQPGKLFRWEYDFVECGEFKENFEYGLQILDCDLCHHSSEEWIAGTSSISSGSRSPIDDNGSSWEGETLTSQTSDAELGEILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P803</accession>
    <name>A0A0B1P803_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 14-3-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000699">
        <property type="protein sequence ID" value="KHJ34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P803"/>
    <dbReference type="STRING" id="52586.A0A0B1P803"/>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="6">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="270" mass="30258" checksum="2508EB24C9C62A2F" modified="2015-03-04" version="1">MGYEDSVYLAKLAEQAERYEEMVENMKQVASEDQELSVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNNSQVGLIKEYRQKIEAELAKICEDILEVLDKHLIPSAKSGESKVFYHKMKGDYHRYLAEFAIGDKRKESADKSLEAYKNATEVAQTDLAPTHPIRLGLALNFSVFYYEIMNSPDQACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAETNAPEQSTAATATNAEPKEDEPVPSESTADATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P875</accession>
    <name>A0A0B1P875_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001360">
        <property type="protein sequence ID" value="KHJ33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P875"/>
    <dbReference type="STRING" id="52586.A0A0B1P875"/>
    <dbReference type="HOGENOM" id="CLU_034705_2_0_1"/>
    <dbReference type="OMA" id="MTNHYLR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="383" mass="42816" checksum="E25DB03C3D215621" modified="2015-03-04" version="1">MPRYSHDLDEDVFGGEKFIGVRAFDAFPKAKPEYVTQTSGGGKWTVAMLIIASILVISEFKDWWHGYEIHSFSIEKGIGHDMQINLDMVIAMSCPDVHINVQDAAGDRILAGDKLKKDMTNWAQWVDLKGIHSLGKDNQGRTTSEEDAYGQEGFGEEHVHDIIAIAGSGGGGGRKKKFAKTPRIKGKPSVGDSCRIFGSLDVNKVLGDFHITARGHGYLEFGNHLDHNAFNFSHIINELSFGEYYPNLLNPLDGTISTSEHHFQRYQYFVSIVPTIYSIDTPYSNNVITTNQYAVTDQSQVVDEFSVPGIFFKYDIEPLLLETEEVREGFLQFLVKVVNVFSGALVAGHWGFTLSEWVMTVIKNRKICSIDGVLNGRTFEKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P889</accession>
    <name>A0A0B1P889_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000854">
        <property type="protein sequence ID" value="KHJ34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P889"/>
    <dbReference type="HOGENOM" id="CLU_012946_0_0_1"/>
    <dbReference type="OMA" id="SAAIVMW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="428" mass="48136" checksum="C93276BFF18DA7B7" modified="2015-03-04" version="1">MKQKPNQSGIAKSAFQILRGGLELQRFPTFCATLVGCYTFFGIIIQQLVFIYLPNLSSLIKLRLSRFISAFIGAWLGLKLLQSKESPEYIQDVTFETPSGRVSKKIRLAGRTIDLTLFAVTRAIDVVGGSIWSRRRNQLKAVGKVNRFHELISKLADPLLFSASSAIIMFNWLYTPEKLPRSYCKWVRSAAAVDMRLISGLRQLRNKALIYGIEPSYPHVFTDLCRDYNWPLEWANHAKTAPVPCEIVHLKDGPSCEYHALARLIRSTTWAMSTYLPLNLMLVLRQPSSKALLRAVRCAMRSSIFLGTYISLFYYGICLVRSRIGPLIFGKSNASLQYIDSGLNVAGGCVLCGWSVLIENSGRRRELALFLVPKALATFFPRSYPMEQQWKESIVFSISTAIVFTAVTEKSNTVRGLLGRVLKTVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T2</accession>
    <name>A0A0B1P8T2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001505">
        <property type="protein sequence ID" value="KHJ33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8T2"/>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="OMA" id="PSNGWIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="641"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="762" mass="87240" checksum="46EF037F997E2C9D" modified="2015-03-04" version="1">MPSLRLNIQDGVFRDSHNREVILRGINVAGDAKYPSSPDIPSHIADKFFDGDNVNFMKRPFAREDAHIHFSRLKSWGYNTIRYIFTWEAIESAGPRIYDDDWIQHTIEILRIAKGYGFYIFMDPHQDVWSRFSGGSGAPMWTLYACGLNPQKFVETEAALVHNTYSNPSNFPKMIWSTNYTRLACQTIFTLFFAGRDFAPNCIIDGKNIQDFLQDHFIGALSYFAKKIHEAGDLEDNPVIGWESMNEPNRGLIGWPDISIIPDDQRLQKGTSPTVWQAILTGSGRACEIDTWDFGGMGPKKTGQFLVDPHGESAWLPADYDESRYNYKRDPKWKLGECIWAQHGVWDPKTNSLIRKDYFHKCPHSDKIIDHEYFTNHYFMEYYRKHRDAIREHHKKSILFCQPPVLEKPPLIKGTKDDDPKMVYAPHYYDGVTLMTKKWNRFWNVDVLGVLRGRYSHPIMAIKLGESAIRNCFRDQLKAIRQEGLDNMGNHPCVLTEFGIPYDMDNQYAYRTGNYSSQSDALDANHFAIEGSNLAGYTLWIYMCENKHRVGDQWNGEDLSIFSLDDLLLPVRPTSPSPSNQATTSLIQSPHPKKGSLDGCIVNSDNLKGTLKTSPISPNLDDPSPELTNNPGYRAAEAFVRPFPIATCGTILNYGFNLRDCTFTLETLKDTTIDSDLPTEIYLPEFHFPKNRCDIIVSSGEWTINSDDSNEGISQCLKWWMPEGRHHIKVIGLQRSQKNLAPTDDNDGFYLNQCQQSRCMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P936</accession>
    <name>A0A0B1P936_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative u3 small nucleolar rna associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001586">
        <property type="protein sequence ID" value="KHJ33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P936"/>
    <dbReference type="STRING" id="52586.A0A0B1P936"/>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="352"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="439" mass="50470" checksum="EB841E8B0E346BA4" modified="2015-03-04" version="1">MKIKALNRQSLVEAGSDVQKVPRNLDPALHPFERAREYTRALNATKLERMFAAPFITQLGKGHVDGVYTMAKDPQSLQRFASGSGDGVVKVWDLISREETWNTTAHENIVKGLCWTNDKKLLTCASDRYIKLYDPYHTPSGAMPLATWLGVSALTSLSHHRSLNSFAAASDLISIYDVEKYNAQPEVLKWPNATDTITAVSFNQIETSILASTATDRSIILYDLRTSMPLAKTILRFASNAISWNPMEAFNFAVANEDHNIYIFDMRKMTRALNVLKDHVAAVMDIEFSPTGEELVSGSYDRTVRLWSRMKGHSRDIYHTKRMQRVFSCRWTPDAKFILSGSDDGNIRLWRANASKREGIKSAKQRQALEYNEALCERYAHMPEIRRIKRHRHIPKVVKKAREIKTEELKAIKRRQENERRHTKKQFEKRKDERTKMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P954</accession>
    <name>A0A0B1P954_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001187">
        <property type="protein sequence ID" value="KHJ33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P954"/>
    <dbReference type="STRING" id="52586.A0A0B1P954"/>
    <dbReference type="HOGENOM" id="CLU_119720_1_0_1"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="119" mass="13770" checksum="83FE841481FF24EB" modified="2015-03-04" version="1">MPQDLPPIGGYDPIQYKRNLPARGFRPAVLLFGMASIMTYGFWRVGQGIREHNELAREKMWSRIHLIPMLTAEEDRDLVRRHLADLAREKKLLGSSTSPYNSERYVRPTFAITPKETTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I4</accession>
    <name>A0A0B1P9I4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative duf221 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001532">
        <property type="protein sequence ID" value="KHJ33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9I4"/>
    <dbReference type="HOGENOM" id="CLU_002458_0_0_1"/>
    <dbReference type="OMA" id="CSCKKEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="223"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="431"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="852" mass="97536" checksum="3223F6A7476C6FFD" modified="2015-03-04" version="1">MNLIPFAKECEHYNPFDPHTGHEQIYVQLILSLALGLAGLFGFCFLRPRWKSLYAARKCRSIRASTLPELPDSFLGWIPVLHSVTEDQVLETAGLDAYVFLAFFKMSIRLFSTIFFIAIAVLAPINNHFDWLPTPGDPQGHRNLSETNIFTYNYYQSESASITSSSVAITDNEDVPDPTYLWAYLIFTYVFTGLAIYFMTSQTKLIIKVRQRYLGCHSSVTYRTFKLSGVPSKLRSESKIKEVIENFGIGKVESVSIARNWKYLDRLLDQRTRLLRKLEAVWTIYLNQKRHIENNSSENRTLYLQNGNQTPQAEEEHLLDQGQNSIELDDCRPKKKVYLGILCWRSREVDAIDFYEEKLRSLDEKIIDARKNQYPSTSTAFITMESISVCQIIVQTLLDPLPLHLLAKLAPAPADIIWQNTYLPRYNRIIRAWIITIFITVLTIFWVVPVAALAGLLDICSIQRFLPKLAKILNSHDILKSLVQTGLPTLVVSLLNICVPFLYDFLSNQQGMISQGDVELSLISKNFFFTFFNVFLTFTVAGTATKFWSTLQDSLKDTTFLALKLAGSVQQVAVFFTNFILLQGVGFIPLRLLEFGSVSLYPIMRMYSKSPRDHWELTQPPVFKYGFYLPSAILVYILCIVYSILPAGYMVLFFGIIYFINSYYTYKYQLLYAMNHPQHATEGAWPMICYRILLGLCVFQIVMAGIIALKNQFYAASLVVPLIPFTIWYSYYFGRTYHPLIKFIALGSIQKKRNSDEIIAGEINQTGFLIDNLIPRNDTVDEEREKESQYLNPNAIAPLATPWITGLVHSSRNSHYVEDDENLFTGIVRENSVSSSMSLGDTHVWRENNNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9L6</accession>
    <name>A0A0B1P9L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9L6"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OMA" id="AKWRFTA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="80"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="582" mass="64741" checksum="C503483E6F4C175C" modified="2015-03-04" version="1">MGSPEMTKAYFNARSIRNSLLLVPKKYHQFQSTRKFGSLSHDFTRKYPFPVGDERRSFNAEAAAWNTANTPLRRRLKGRHIQMIAIGGSIGTGLFIVSGTALATGGPGSLLIAFILLSIVLFCVMQALGEMAVAFPVAGSFSAFATRFIDPAWGFAFGWTYALLWTFIFPLQIISATTSLQYWNSPIPGWVATTGFLLLIITINLFNVKVYGEIEYTFAILKVTAVVGFIILGAIINCAGTQDSGYIGTQYWRNPGAFNNGFKGFCGVLVEATFSFTGFEQMALAAAETQNPSKAFPKAIKQAFWHIAILYTITIMMIGLLVPYNSPQLSPVDDIDIKASPFIIAIQSAGIIGLDSVMNTIIIIAVLSVANSSMYGATRTFAALAEQDQAPRFMAYVDQKGRPLVNIGLVSLFGLTAFIYETSLRHMAFNWLLTLSGVTTILSWCSICYTHISFRRAWIYQGLHQNDLIYCSPTGISGSYFGIFSLILILVAQFWVAASQEEEDVQRATDCAVKFSGAYSTVPIILILYFGYKLWYRTQCVNVADVDLITGRNLLENEFQRRAWIEEKSRWPRWKVIYHSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9X7</accession>
    <name>A0A0B1P9X7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000374">
        <property type="protein sequence ID" value="KHJ35497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9X7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9X7"/>
    <dbReference type="HOGENOM" id="CLU_054969_0_0_1"/>
    <dbReference type="OMA" id="FEAQFKP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="29867" checksum="62A045B14CFAEDD9" modified="2015-03-04" version="1">MKSSESDESTSVLGNKLQEIFRRHFEAQFEPLSCIQSGIDYTIPNSKRSLEQQDQAHDESDWNGFSDEETSNQIVEYSVTQTQPILMSKAELKSFMSSKPPTQGLSSTPRKDIQDNDDPTEVENIKNDIVLHRFLSESHLFESAKNPTLSGNNRHKAMDLRLQALGSKKSILRQQNMPMTHRKGILAKHKSIEFKRRKNAIENGIILEKVSMENNKTIRKRHNNAIGAPSVGRFSRGILKLSKEDIKNIQGPTQKYPKKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA06</accession>
    <name>A0A0B1PA06_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000367">
        <property type="protein sequence ID" value="KHJ35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA06"/>
    <dbReference type="HOGENOM" id="CLU_2575626_0_0_1"/>
    <dbReference type="OMA" id="YLRHICE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="92" mass="11168" checksum="AC2A49A99BF1A705" modified="2015-03-04" version="1">MTNIPKSNYAINRELYGMDIDIENKELITKPTINRYIVRVMRIWKNSEYHDEALIEAFQEDFAERTSQIFDIANRLLLRDLRDYLRHICEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA18</accession>
    <name>A0A0B1PA18_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001386">
        <property type="protein sequence ID" value="KHJ33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA18"/>
    <dbReference type="STRING" id="52586.A0A0B1PA18"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="212" mass="23486" checksum="BF753FE96326B8EA" modified="2015-03-04" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDAKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYENVTRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAKAFASENNLSFIETSALDASNVELAFQNILTEIYRIVSQKALDNGETTQTNISAGTNISLSKTAEEGNTKSGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA98</accession>
    <name>A0A0B1PA98_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EV44_g1762</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000492">
        <property type="protein sequence ID" value="KHJ35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA98"/>
    <dbReference type="STRING" id="52586.A0A0B1PA98"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="YFKNGGP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="42"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KHJ35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="420" mass="47861" checksum="BD98ABE9673FCA76" modified="2015-03-04" version="1">MDSNSFPKARLDLDPIFWEDDYSIELCNAVGYQSKVRVLDRYQIVGFISSGTYGRVYKAKGRQGQLGDFAIKKFKPDKEGEQVQYTGISQSAIREMSLCSELSHSNIIKLIEIILEDKCIYMVFEYAEHDLLQIIHHHTQPNKYPISSSTIKSIMFQLLNGTHYLHTNWVLHRDLKPANIMVTSSGEVKIGDLGLARIFHKPLHPLFTGDKVVVTIWYRAPELLLGSRHYTPAVDMWAIGCIFAELLSLRPIFKGEEAKIEAKKVVPFQQNQMQRIVEILGVPTKEKWPNLVHMPEYSQLSTVNSNHPKSFLDKWYYNKINASRSSPTSNASLGSEGYKLLAGLLEYNPERRLTAQQALQHPFFSTGDKLCSNCFEGSKVEYPNRRVSTEETDICSNNFPGMKKIILPLDGSRAAKRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAN2</accession>
    <name>A0A0B1PAN2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative phosphatidylinositol-glycan biosynthesis class s protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001090">
        <property type="protein sequence ID" value="KHJ34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAN2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAN2"/>
    <dbReference type="HOGENOM" id="CLU_010026_3_1_1"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="57668" checksum="E94A3AECE8DDA32E" modified="2015-03-04" version="1">MSAPKSNNSDAYSISPMPKFKYRKKDPPPESFESVRVRRLIILSFWVIIITIGVPIWWTTTAIFRASLPTNQMLDWANGKECRPVFPLRIAIKADSLNINEAQNLLRTTQHALDDLNDFSAHHLRLYLLPRNNSIVKDRFFTSTGSEEALVIRLIPSNDTKSSLHPYFSILDIYYTPNQVPSSSSFSSPLATYITLQLRTLFSEERAMISHLLSISNSDHGAEYKPSDALQKWTSRTMKYSPSYHLTFSLFTPTSTPTNWPIAHAIERYINPFIESLRPISDFSIDTQIQFYATPGVSGSKLRKEDLSLFINAAEWPLSPSIGGEPTINFVVYVGDIEIHGGANSWLIPQWGGVVILSPSEVEDLRPAMLIFAKQLLSLLGAPETGSFPFRLQTLTRVRSASLLLKASSTLGSLARLTLALPSIAIPRSVADGVTKTIVSLHHACEGLGGHVGLEQARNAERQAEKAFFEKSMVGQVYFPDEHKIAVYLPLLGPVGVPLVVGVIKEVKSWYKGRKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAV0</accession>
    <name>A0A0B1PAV0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fad binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000258">
        <property type="protein sequence ID" value="KHJ35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAV0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAV0"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_5_1"/>
    <dbReference type="OMA" id="LCCGGGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="198"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="616" mass="68523" checksum="D1411443F7FF66C2" modified="2015-03-04" version="1">MSLLPLPIRTKSAAESISKEALIIKPSQFSKPSLSSPLKKPEESLSPSLPPTSELISLNEIESETQFDIVSTDLIRTCCGENCCKIPQKIVECDLERIEPPDNEAYRSLQLKIESIPKVLSGIPEVPPKTVSILPINDSISHISADLILDQGSSDSVNLTHTETSTTNADLLATASANDFKIESNIHPPKFVKPHAPYDLYIARIHSARELTQPGAEKRTYHFDLDVTDYPVETGVDFKVGGAIGVSAPNIASAVDEFLDLLCVPRYLRDRPILLKTSSGRWPTVWGDDKPRELQTTRREILTWCSDFQSFRVGKSLLRLLAEYATSESEKKILYYLTSDQGQSTFCDLRTGPYITVPQLLYAFPSCKPPLDAMLSILPQLVARFYSLSNDPIDTSVTEDGNKRIIEFAVTVWEVSNWDGSIRTGIGSGFLERMAKKFIEVEKRGEKPNISIPMFKGLMSNPLARDFASDGPMLLIGAGVGISPFRGFVQRRLRNANCANKVWVLQGIRDSLFDELYRGEWGIHEADLKKVIQSRKPSGQSKYVQDEVRAQADLVWFIINSLDGRIFVCGSSRGMSEGVTRALVDVAKLKGNLDEDDAQQFWSSKKEAGQFVVEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB91</accession>
    <name>A0A0B1PB91_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000185">
        <property type="protein sequence ID" value="KHJ35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB91"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="44023" checksum="5E823D982D89E7F2" modified="2015-03-04" version="1">MAPPLGSKRALPPDPPDAGNRVSKPKPTSGKTSRTNVAKNHLLLKTVDASCKGVAIEKVPSEGQGSTDHSYESDDSMESAIDDRRDHEHLGEDFPALPRNTLTTAEAKIPSPSNNSSSKSQGSAASLMGAIKGLLDLTNDYLKNLEIEHPGIGPDFLALIADGASRAMRGERVYRDLSRIEPTQKHPVQETWAEKAKDQSADTKVFNLKRKTLKATPPQGQSKEDRRVMIRLKPDHEARKSGSFELRQTIQKLVPETSLVSDAWIVPSGIAVLAPTPAKAAAILQAKKAIEDRFGNALVERQEAWTTFVIGPINKRIRCLDGTQDPMDGLLQEELAHIRDTVPIRDMGWTRRSQNEEPYGYIRICVPESKAGKFPSRLRIFGEAVSIQRIRKREHVHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBI2</accession>
    <name>A0A0B1PBI2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ww domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000154">
        <property type="protein sequence ID" value="KHJ36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBI2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBI2"/>
    <dbReference type="HOGENOM" id="CLU_003963_1_0_1"/>
    <dbReference type="OMA" id="NPYPEYH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1173" mass="131918" checksum="1AB0E9348CB679CF" modified="2015-03-04" version="1">MYNRDWKADKELEFSKPFNNSEKCPVIEPLRINKPRITDYQHIGQTTLSSKACSSEIRLPYPDGRNDFNFPLPFQSPSHHATYLNESRSRSRDSSRKKQFILEAEMRPEIHLRGKSMSPKLRLESDNEITNYKVQRGDLTRPFLGAHDRSFSDLCVSNMLKDQTLKPTSHNIRYLEPRRYHNYEYLPPQELDASPASSKTKVSHSTNSGVNRIDSVISISTTRASRGSPPLSPSELDSPIGSPQVKLDRFENRKIATALPRADALNNQHSFTMNEAQKFYTQGPAITSKISPPIGPLYTDSNNSRPWSSSNEYCGNSKVAGPLNMPLKGQTTQVLRQQIQQLNLSPSPPPAYSSVSSETLEDLQAESNKKKTEIIITTHSAPYQAAAASHTLTEPHYSEHPAFANEPKESMSNIRPAFQTNLGQNYSHSTDNQITCPNSHPPLPEGWISHLDPNSGQYYYIHLQTQFTQWEFPKGPTPLNYNTAQPSPGLSMFGNPHKSPVSNTFTIGPITSPSFSSLSASYKDSIQRIVSQTPTTAGFTGPPPTAGIEMYKIKPTNSVYFGPYLRYTNMDIQKGIWLGSIMLVTDALQPPTIHIHKSSDLSPNPRQLKPESIFTHQRWIFHRYNIDLEMGDTSSEKWTYAITSHLGCTRYEFLVAGRHEMNWKFIAHSGNDFTVHTSANERSRLGGFGTMWKDILQKHSESGGFHVQLGLGDQIYGDRLWKEIPLLKQWLAISGKENRKNTPWTARHEEDVSHAYFHYYTSHFDQSYLREAFAQIPHILQIDHHDIFDGFGSFPDYLQSSDVFENIGRIGIRMYLLFQHHTTLDVLRKSSGELDLFTITGNGWHFTKFLGPAVAVVGPDCRSERNQRQVLAGPTYQGLFPKVINLPRSIQHCIWMISVPVIYPRLDTVESFAQTFTTAKKGVTTTYNLLGKMTSSVAGVVGGKQAVASGFSQVKKVVGKSGLMGGVLNTFGDIDIADDLRDMWTHESRDLERTYLIRTLQSIAHQRGMRMTFLSGDVNCAGAGLVYDPSHPSNHKTIYQIISSAIVASPLPCYVLKMLHNHKTLYVPANGQKTTNAVSDTKEDMIEIFRSEANGMPREMKKLIGRRNYVIFMPFDPEDINGTNYSATNSIERQNQKLKKISIAVDFIVQDEGSTNSTSKFGPVIIPGLEHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT0</accession>
    <name>A0A0B1PBT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT0"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21202" checksum="2D0C0ADBB2349A05" modified="2015-03-04" version="1">MQQKVYFPPNSTRPQQHKKSRSGLRRNVPTLRSSKNLPNYAALSKPEERLFLRIDLDHKWRLLAPSGVREILCKNLNCVPSDVTLIARTPTGFALTIKEKEIRQKLLNDGDKISSQGAKLELASDLITYRIVTLPITLRTSSGSVTVDDTSFVAEIIRVTNVAPKMVRVHGKTCSGAPHCSWLAHFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT8</accession>
    <name>A0A0B1PBT8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001032">
        <property type="protein sequence ID" value="KHJ34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT8"/>
    <dbReference type="HOGENOM" id="CLU_034315_2_0_1"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000010">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="115"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="432" mass="47097" checksum="E75BFF754FB58AD7" modified="2015-03-04" version="1">MSDNVKNNSPPSYQTIPITTLLQRMWPSPSDSNVTAEEIAQVISYLFTNQLSLVQAGALLTCLHFTGWELRPDVLAKCALSMRKAAVPVDLDSLSTVISRKITARNFMSHYKGGLCDIVGTGGDSHNTFNVSTTSSILASALLQIAKHGNRASTSKSGSADILQSMQPVAPDLDNVSPKNICQIYEKTNYAFLFASNFHPGMRYVAPIRKELGWRTIFNILGPLTNPVEQLLEARVLGVASREIGSLYAEALKIQGVKKALIVCGEENLDEISCAGKTYCWKLNDSSSIHPEESTDSFSSDNGDDLIKIESFSLEPADFGLPSHPLVQVSPGKEPKENANILLKILQNQLAYDDPILHFVLMNTSALFVISGICEDDTSNMGTLDDGVIITERGPGGGRWKEGVRRARWAIESGEALRQWSSFVDLTTSNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY2</accession>
    <name>A0A0B1PBY2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptidase m16 inactive domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001002">
        <property type="protein sequence ID" value="KHJ34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY2"/>
    <dbReference type="HOGENOM" id="CLU_006065_0_0_1"/>
    <dbReference type="OMA" id="WEGFARI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="298"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129333" checksum="42FB0915E17E7688" modified="2015-03-04" version="1">MNGSHEGKDCANLLGYPRHAEHTDLRGHRTGLTVTELSCANLELEGYYVMLSKQCGEWRITLDFLSKFDCPTGPLDGHGYPITSIDNIIKPWAFREVEMPSQACRKASFFLKTQHFSTDYSPVAISRYVSERTGMHVVIVDKKGPKVNGYFVLATEIFDDSGSPHTLEHLVFMGSKNYKYKGLLDKLASRAYSNTNAWTATDHTAYTLDTTGWDGFSQILPVYLEHVILPTLTDEACYTEVHHVDGKGNDAGVVYSEMQAIQNTSSEIMDLRSRRLLYPENVGFRYETGGLMENLRILTPERIRSFHKEMYQPKNLCLVLVGEVDQVHLLEILDNFEESILSDIIPPEKKFKRPWIESAQPPPIKETIIETVSFPEEDESSGEVTIALFGPDYGDEISFAAIDLILTYLVGSSASTIQNVIVEKERLVSSITYNMDSRPNTVIWFVANGVATEKLALVEKRIFELIKEVYSNPLNMKYLLECIRREKRQVKFQAENCSDFFALIAIDDFLFGKRDGSNFEKIKSLYLYDILEKWGEDDWRSLLKKWLLDAPHVSILGTPSKAMVDEIKSREEARIEARKKELGPTGLKELDEKLKAAIAKNDTEIPTTLLEKFPVPDTESINFIKSLTARSGLAKNLGVPNNRVQKIIDSTHNVPLFIQFEHAPTNFVHLTLLLGTAGVETNFLPLLPLFFENFFNTPFMKHGKKVEFEDVVKNLEQDTISYNISGGESVLYDEGIAISFKIEPEKYSTAIEWIHTLIFDSVFDETRLSATIARILAGLPELKRDGNRMANSVDSIIHLNSKSSVKARNTLVKAVYMKRLKKLFHQEPKKVISSLENLRNSIFVFNNMRVLVIADIDKLISPIEPWKLLVDKLKDVDNPLLPIINISERLNEDGKNPGNYGVVIVPMSNIDSSYCLASTKGPKSFTDPILPALCVAISFLETVEGPLWTAIRGKGLAYGAHFRCDVDGLIQFSIYRSPDSYRAFQAAKAIIESYLNESTTIDKYALEGAISSIVASYGNKQATIAMAGKSHFVNSVIKGVDDDYDTNMLKAVRNISKTQILDVMRDFLIPVFTPGKANIVLTCATIMKDKNSKSFEESGFKVRVQELKDFEETYGLEETTDDEDESEEDEDNSDFEASSTESNASDSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC24</accession>
    <name>A0A0B1PC24_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pleckstrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000101">
        <property type="protein sequence ID" value="KHJ36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC24"/>
    <dbReference type="STRING" id="52586.A0A0B1PC24"/>
    <dbReference type="HOGENOM" id="CLU_012320_2_1_1"/>
    <dbReference type="OMA" id="WDRDTQN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="734" mass="82438" checksum="2A00A64DF8461851" modified="2015-03-04" version="1">MVTNTISEEKVKTENNPMVQKYSRYLTVKRIAANSNSQDEPQIQKPPVTQNDVSKAQSMGRYRRPKLTSRADSALVAPVITVNKSISNTSIPKEQQRKDLNVTENSSSHQPLENEEEQRTDVAPNTQMEQQHQAQEDKEIGSTVCQTNSHVSAADLLAVQKVKDLQRLKAQLDASLPKSPHTCTQKPRKENRLVGLFSKKKESNCSPPNTPKNPSPSSMTKSSPVTQSSIKQNIEQGGGGIVPQIDAPISAINAGERRVLVRFKQSSISLPINLETTAIDLIYTTADVLNKQITPSSTILLESFLQLGLERQIRTYERIRDVMNSWDRDTQNALIIEKRYNQYETELETNHLTSEPPAGVTVVLQHSQKPGKWKKRYVTLLASGQIFIAKNAGAKSTDKDYQNICRLSDFDIYKPMSERARKNHNPPEKNLYAIKSQQKTSMFLSSENYVHYFSTHDDLVGQKFYNAVQNWRSWFLLNRMGEGNRRLSQSYISQPILSRIESNTAQTRRSSIIEKPNSSKPLQASKDLNQVNTHKADEIERSKFHFEDQPSPNLSVRRNSRKYAAFPNKLPIDDGGEFASSSLLGRTYAVRKRELHEETINQQRNAIASVTNMNPDAQSPRGLVDLTASTKEPPQWSQSCRGHGIRPIDGVPLVDIACSPRQGSQRTDISRSNTLLGRKDSKFSQKSGRQNLSSAIEEGPFVEGGLIATIVNCEANSAYKSRTAISNFNTRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD3</accession>
    <name>A0A0B1PCD3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000207">
        <property type="protein sequence ID" value="KHJ35918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD3"/>
    <dbReference type="HOGENOM" id="CLU_075332_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="170" mass="19201" checksum="C73146FD22E8C277" modified="2015-03-04" version="1">MATLRMAFMRSSIRIREPFRTRSLMFCHPSTRRGYTSGRSKKSKFLEEALWAAGSIAITIPSCWYLLSGREVHVNHHDDGHNSQENSNDHLEEKNSKEIDENSDENSDELVEEKEGVSNESEEEQYLPHNDSQNDTSNKCISCEGVDGDTDGKASSLESVDDQCKKQDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE6</accession>
    <name>A0A0B1PCE6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000201">
        <property type="protein sequence ID" value="KHJ35933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE6"/>
    <dbReference type="HOGENOM" id="CLU_028123_2_1_1"/>
    <dbReference type="OMA" id="RAWASWN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="60030" checksum="7F4AC196EA732CAD" modified="2015-03-04" version="1">MSSNTAKVNYSFTPERRYSKKVAIIGSGSAGIGALWALNRTPHDVYIYEAENRLGGHTNTVEWSYGKSKTLVDTGFIVLNTATYPNFISFLKVLGVPVMPTEMTFGVSRDSGLFEWAGSSIASVFAQFSNILSPRMWRMIFDVIRFNQFALDLLRDENIKLKLDAASNQDGRQSKYLRDQELTIGEYLAREGYSDAFRDDYLIPMTASVWSTSPDKCSLQFPAKTLVRFMWNHHLLSIITARPQWLTLKYGAKSYIDAVMKGFPPNHVFLNSPVKSVRNEGSSKVRIFLPNGKSELYDHVIIATHGDQAFQLIQDGANDEERSILSGFQTSKNIAVLHSDLRLMPIRRGVWSAWNYITKSSATSKNIDQVCLTYNMNILQHIPRSVFGDVLVTLNPLYPPNEKLVQGTYTYSHPMYNTDAIKSQQLLHRIQNKRGISFAGAWTRYGFHEDGFSSGLQAAIEHLGAKLPFQFKDSTFSRGKQPALSTLDLILRVLILAIQNLIVVIEILFCIERSPKESYGLAECPDIMKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCI4</accession>
    <name>A0A0B1PCI4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative brix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000041">
        <property type="protein sequence ID" value="KHJ36387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCI4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCI4"/>
    <dbReference type="HOGENOM" id="CLU_040063_3_2_1"/>
    <dbReference type="OMA" id="HFSVSNW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="185"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="419" mass="48389" checksum="78607BD1D22F0CAA" modified="2015-03-04" version="1">MGSKRAKPNASKAILPFKVSNKLKRQELHINRKRTLESNRRDERFRRKREENKDPELRRKRLATNIPQTIERKRVWDEIDDDILGASVDVIQLERSRIEEEEKHKQDLLPNLEENKVDDDDDDLDSMLDSEDENEDKADNTVYDQPRAPSIAPSLAVSVASTNLDLTPSSLALKFPTLFTDTPPPAPKILITTSLNSTLYHEAKLLCTFFPNSNFVPRTSHRYGHKYSLREIAKFANNRQYTSIILLKEDQKKPTGLSVVHLPSGPTCHFSIANWVEGKKLPGHGNPTNHYPELILNNFRTPLGLLTARIFLTLFPPQPEFQGRQVVTLHNQRDYIFVRRHRYIFRDKRETEKSVIGPDGKPVKGVEDIRTGLQELGPRFTLKLRRVDKGIGRAGSQDKDAVQWQWKAHMEKKRTRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD25</accession>
    <name>A0A0B1PD25_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gtpase-activating protein gyp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000465">
        <property type="protein sequence ID" value="KHJ35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD25"/>
    <dbReference type="STRING" id="52586.A0A0B1PD25"/>
    <dbReference type="HOGENOM" id="CLU_018687_4_0_1"/>
    <dbReference type="OMA" id="YHPPINT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="217"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="61449" checksum="45FE5F6D07D7A13A" modified="2015-03-04" version="1">MKVDNLSLRPSPVRPKTPTFPPKSPLPMPTNKFTLNSNLSLRASYNDFLSDTNNDWNLESSVDNYQEYDYRDEEGDDFGLPRMMNIQRSKEKMASKKHKASAEQDTYLGVTSQKQKSTKYTSRRQSNSADIAIERPNPSFQTAKKCEGKILRPQYKDILRDPANSLHLIDHPSIEINALPREIDFHSARITRINKFKKILQATSINLTSLRAVAWSGVPEEVRAMTWQVLLGYLPTSSERRVGTLDRKRKEYLDGVRQAFEKNSSGSSSTGKARGLDEAIWHQISIDVPRTNPHLELYGYEATQRSLERILYVWAVRHPASGYVQGINDLVTPFWQVFLAGYVTDSDIESGMDPGQLPKAVLDAVEADSFWCLTKLLDGIQDNYIFAQPGIQRQVAALRDLTVRIDEPLAKHLESENVEFIQFSFRWMNCLLMREISVKNTIRMWDTYLAEEQGFSEFHLYVCVAFLVKWSEKLRTMDFQEIMMFLQALPTREWTEKDIELLLSEAFIWQSLFKGSSSHLRGGSGRKFSSSVLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDG6</accession>
    <name>A0A0B1PDG6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g6195</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDG6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDG6"/>
    <dbReference type="HOGENOM" id="CLU_000288_2_1_1"/>
    <dbReference type="OMA" id="EVHYTSP"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="682" mass="76398" checksum="58FAB9C785130038" modified="2015-03-04" version="1">MASEECMMRGVVDPETLFTKQNCIGGGSFGKVYKGFDKRTGQAVAIKVIDVENAEDEVEDIVQEIAILSELHSPYVTQYYGSYLKGSDLWIIMEFCAGGSCGDLMKPGLIGEEYISIIMRELLLGLEYLHSDKKLHRDIKAANVLLSSNGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADMWSLGITALELANGEPPYSDIHPMKVLFLIPKNPPPELEGNFSKAFKEFIELCLQKDPRKRPSARELLKHPFVRRAKKTSYLTELIERYERWAIHQQKDEDLEDDGSQRMNQYTPQNEDLWDFGTMRPMGTRTSSRIGLHLMADSATNSRSLRVLESNDGILDEKVPSSPTKIKEISITSNTETVKATSSPLSGQFPHISQGRPVNRQELLSPTKVPLPPSPLKPKSINLPPHEESKFNVKFSECCVSSQEQIHEDMNLLSLDSPPSWDLASTLSPLPVNAIRQGQQRLDPQSHLTLPKIGPLKLPEIPPFRGQSPNSQASVSKLSNGNSKKQSLPQQTVIPQNVNVRNIDLESTKTLASKIDDNLRSKEVVLSDSYIVPVDSNGELDALNDVIFPALEEALKRRQYRLQQAFRGSGTTPKQQRSQAAHEKVRKLVYKLAHVCREIDHWDKQEPVGMGKDVDIFLEGLLEEILVRVEPADDDEIHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDK4</accession>
    <name>A0A0B1PDK4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000732">
        <property type="protein sequence ID" value="KHJ34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDK4"/>
    <dbReference type="HOGENOM" id="CLU_143693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="154" mass="17366" checksum="CB67C99B99D8A211" modified="2015-03-04" version="1">MIRLDPEHEARKTGSYELRQSIQNLVSDSSLVSDVWMVPSGVAILASTPVKAAAILQSKSAIENRFGNATVERQELWTTFVIGPIKKKIKCIEGLRDPMDGLLQQELAHIRDTVLIREMSWTRRSLNNEPHGYIRICVPEPKAGKFPSRLRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDZ6</accession>
    <name>A0A0B1PDZ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000004">
        <property type="protein sequence ID" value="KHJ36473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDZ6"/>
    <dbReference type="HOGENOM" id="CLU_832076_0_0_1"/>
    <dbReference type="OMA" id="CKSSLRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="334" mass="37556" checksum="53FB993CFA3347EA" modified="2015-03-04" version="1">MLVPLNLEDNRYDNSDISMYPHQKLLSSGLKDHDKDHSNFDGNFIGYDMDCSLVSKPMCKSSLRIPVLPQRNALRTVTKPRKESVNARRISIENYKEFYNSSILRASDPHDVYLSSEEDVSVKDSNEDFLFDSDDSDKDYELKSYDRESHAVTAKAISFRAAGKPQIIEINNQSNNSSPRTSVSIPDFPSRRPLLPRLPALSLNLSEFHLDANELFPSSPHPLSPQKPAENLKSNTLANDNFYKNDSYPSPSKLISEPNTSLSIFRRGSLLSRRSQITQSILQMPTQATRNSATTASKISSRINALKHVTRNIKNAGMPKINLAYTPGVVPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEI5</accession>
    <name>A0A0B1PEI5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000446">
        <property type="protein sequence ID" value="KHJ35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEI5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEI5"/>
    <dbReference type="HOGENOM" id="CLU_750473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="369" mass="41099" checksum="424A66D344F54695" modified="2015-03-04" version="1">MLRVINILCTGDAANWIDSTPRVREQITNRKNATEASVAYVKCALEERFPGCVSDQTELSIQSEVENLRQGSEEPVATYYARTVRLLNRTRGQDKPKAESVGLPLTGPEEFTLSAIIMAYTRGLFDEILRKEVFAKSGASCSSLWKCQEVIIETQRTMELMKQYEEQAAENHELQRLRDLVLSDCGQLSSVVLAAKAELSFQVMKQAPMRPPHLDLAQEHSNIQPQPPYHPSYHSRGQGNTRGRGGVQITQNWRDNIGLKKEGNPHPPRSSSKNPYVNMSIAYDKNIHLCVGCGKTGHVKPNCKNPPLQLWEQAYLKQMVFGGPGISAHLLVLESEGAYYEEAENSQNQEHGYAFEKASAASSVLSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEI9</accession>
    <name>A0A0B1PEI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000555">
        <property type="protein sequence ID" value="KHJ35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEI9"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="34572" checksum="4A5682F8578843B3" modified="2015-03-04" version="1">MICTTVYGNIESILANLSDETEKEEVVALKAYLRQAIANFAAVGNSLNPPKILSHSRPTKGKGSGSGKGKNIELNIAVVIPQIPSPSQTQRAKSEEATNWATVLKPTVPAFIRKEHGEVKVINSILVDEVDRVCSVCPAHLKLYGGNKTEAPHTSCMAFFPKAPYGRFSVFDESGIARPFKKQQPLKLCKRCNGHNSIKICCRAPSYGNDGSTIHTEDLCMAATKCRNCGGSHRSDSRRCLARPTSPGAPTKEQLKNYRQAGEREFQAVLQAKAAEELAASDKTNNTELTCSQASEVDNDIDNIPASSVDLPTVDAMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEZ7</accession>
    <name>A0A0B1PEZ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative saga complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000370">
        <property type="protein sequence ID" value="KHJ35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEZ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PEZ7"/>
    <dbReference type="HOGENOM" id="CLU_023535_1_0_1"/>
    <dbReference type="OMA" id="AFEWEAL"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="329" mass="36346" checksum="6BF2DA3CA5094BC0" modified="2015-03-04" version="1">MSAARNRAPRNGARGAAADALNPQELWLEIVGILKDIDKGEAKAAANRNSIIEGEERLTAKRDSGKTISVAETDLHGALFREGVRLSEQQITKLQDTSFITKLELLRDIRMSNELEAAAETSLTARGSSSRGSHVDCDGPSDSPGLSPAEVRQVRKLASSRNNSQTPKVADDVKSFTSESNERMPKAKVLYAVGDKVAFRRKQQVTHPDGKVTEELEWIQGKVNKVIGEGKSRRYEVRDPYYTPESNDGPEFYKSSASQMVPIPVEGSNLEVYEVGKRVLALYPDTSQFYRAEVKGTLNGGTHVQLLFEDELEGILKTVERRFTLDHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF63</accession>
    <name>A0A0B1PF63_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="20">3.1.-.-</ecNumber>
            <ecNumber evidence="20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EV44_g6514</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="20"/>
    <dbReference type="EC" id="3.6.4.12" evidence="20"/>
    <dbReference type="EMBL" id="JNVN01000352">
        <property type="protein sequence ID" value="KHJ35551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PF63"/>
    <dbReference type="HOGENOM" id="CLU_001666_2_1_1"/>
    <dbReference type="OMA" id="SWFDTPC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 20 26" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 20" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="23">
        <location>
            <begin position="563"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="DUF83" evidence="22">
        <location>
            <begin position="771"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="24">
        <location>
            <begin position="1126"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="24">
        <location>
            <begin position="1231"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="25">
        <location>
            <begin position="1302"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KHJ35551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1659" mass="188274" checksum="57E5FDAA7BA1D469" modified="2015-03-04" version="1">MPIQKSFSEQNHSVYSKQSWGNNRSMLKKQKINPNSKPLQEKPPLPVSTATKNKLSNFQYAAQANNQKKTRLNQWLNSEKENGDYVNRKIQVVGEQKVRGKEKKEIDPNPFNHGKNKSPSTPSSKLALPDLIGMVDFRRMKQDISPEERLEWDHKKGELHDFSLNFDSGKVSAKRARSSSPTGSSPTHAPVQFDPGSELWGRYYRNGSKFSSSQSQSISSLAQIMHNSSPKPAKLDVNPRSMVEFRRANSCGDNFPKRKKSSKRDFRRNFAESPLNGSSKLSILIERVRDGLNRSKPPHVTLKKPLNSKISSEYVEASGEKESCEKYTTTVESLLKNTLSAEVRAEKSLVGQKKNTQNDSSGRSENTDYGDFDVDDFDTNIFQVSRSNIGAPMLHHEIELTPFKPLGTSNLKSSSSEKKSRSCITSNLQPFNKISNNDTTHDFDDSEDDLLSVDLELLVSQYDNQSGTELKNMSPIRKTSLCQEKIIKTASDDEFSDDGLDDDDFKAAEASTLQTHNSLSTLQQRARAIQRYLVTDINDSTYKDPCGREKLEKILELRIEHINNLRFVHLRGIWVEIPVTVDVFVHVIGSFNKNGHCIIDDAENLIILHPDHLISSTVVADSFSCVRRAVLQDRIKATSGPNPSLVYGTILHEIFQSAMVSNRWDSAWLTELIKNIAIKHVEDLYIVKIQVPEAVTYLQGKMHEMQSWANKFISPYPKPGALVKSLNGASSSMCIDKLLDIEEHIWSPTFGLKGNIDATVQITVREDNRQRTLTVPFELKTGKNPSTSHIAQTALYSLLLSDRYDIEVAYGILYYMETSETKQIPAIRHELRHMIMQRNELACFVRERSFQLPPMLKKEHLCNKCYAKVPCFIYHKFADNGTGETSGLKSKFDDIVRHLTLRHKEFFLKWDDLLTKEETEYMKYRRELWTMLSFEREKLGRCFSNVIIEPGSSEENHERNKISRYQYIMVKHESKNEFSFLDSQITAGEPIVISDEKGHFALANGFVTRVWKHKIAVQVDRRLHNTRIRQPGFNEVNKQVFTGIMDFTKQSKDSDEEFNKTIPSIKYRLDKDEFSSGMATVRNNLIQIMADSEFGSRKIRNLVVDLTKPRFKARTSPYGFQAHDEINVDQRRAIEKVMSAEDYALILGMPGTGKTTTIAYMIRALISQGKSVLLTSYTHTAVDNILLKLKDQSIPILRLGQLSKISPEVQEFVTLAANTKSSFEEIRSDWHDTPIVATTCLGINHPIFNERLFDYCIVDEASQITLPVCLGPIRLSHTFVLVGDHYQLPPLVQNEEARKGGLDISLFMLLSEGHPDSVVYLEHQYRMCEDIMTLSNSLIYNGRLKCGNQETAQRKLLVHNMDNLQYCHTLPTTSSYSKNICLGPAESRCWLYDLITPATRVAFINTDPLLPLSREEARGNRIVNPTEANLCTLLVNGLLSVGVSASNIGVMTHYRSQLALLNHYLRAHKEVEMHTADRFQGRDKEVIILSLVRSNDAQLIGELLKDWRRINVAFTRAKTKLLVIGSLETLKGSEPRTTNEEEMVSRFVKLMEIKNWVYNLPVGALEDHPFMEIQTQATVNFGQLSSQNLGSNKTSKSNQLQSEFNLNGTGEIKIPTKENQCSVISGNCMKRPNKRIVGKRPFNMPQEGILADVISEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGN7</accession>
    <name>A0A0B1PGN7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000031">
        <property type="protein sequence ID" value="KHJ36415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGN7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGN7"/>
    <dbReference type="HOGENOM" id="CLU_000445_72_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="201"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="382" mass="43138" checksum="3615D53AFEA11750" modified="2015-03-04" version="1">MSSTLVTTYARSCRTLTPSLKKPTQSSFLPGIVRIACFKLGGNIKDIPVTTIQVLDKADRPKHSRSKSKETRIIQSDFKRKKAQNIASSNLELSQIISCNSQNTPIPSRCQESFGLTETITYEKQGLTSPKRSLEQCSKTSELSIQKSVTDKSLIQEANTHLIRVEPKLKPIIEQNFCHLFSPEGLLQEVEPFGALTNSIISQQVSSAAAKSIKKKFISLFNQNNPDVTKYSYPTPSLISTTSIETLRTAGLTQRKAEYIKGLAAKFESGELSKDLLFNAPYEEIFNTLIKVRGLGKWSIEMFACFCLKRTDIFSTQDIGIQRGMAILLGRDIAKLRKTNGKWKYITEKEMDNIARKFSPYRSIFMWYVWRIEEMSLSALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHB6</accession>
    <name>A0A0B1PHB6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative bifunctional purine biosynthesis protein ade17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5244</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000203">
        <property type="protein sequence ID" value="KHJ35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHB6"/>
    <dbReference type="STRING" id="52586.A0A0B1PHB6"/>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="595" mass="65090" checksum="CA24193E92521369" modified="2015-03-04" version="1">MSSNRKIAIISVYEKTGLLDLAKGLIKHNVRILASGGTARMIRESGFEVEDISAITHAPEMLAGRVKTLHPAVHAGILARDLASDEKDLADQNINKVDYVICNLYPFKDTVSKINVTISEAIEEIDVGGVTLIRAAAKNHGRVVILNDPSDYAGFLKELENGEISERSRNFYALKAFEHTADYDASIADFFRKQYAGDGSKQLALRYGANPHQKPAIAFTKSESLPIKVLNGSPGYVNLLDALNAWPLVKELKTALEMPAAASFKHVSPAGAAVGVSLNEEESLVYMVNDIEGLDKSPLAQAYARARGADRLSSFGDMIALSDVVDVPTAKIISREVSDGVIAPGYETAALEILKKKKAGKYLIIQIDAEYVPPSQDCRTVYGINLAQHRNDIQICSQSFSSIIVPKGSGSLTESALRDLTVATIALKYTQSNSVCYALNGQVIGLGAGQQSRIHCTRLAGDKADRWWLRFHPKVLGIKWKKGVKRADKSNAIDLLVSNELPDDGPEREDYKGFFEEIPVDFTKEERKEWLQKLQNVAVSSDAFFPFTDNVYRAARSGAKYIAAPTGSQNDAAVFEAAEKSGITFIEQSIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHF4</accession>
    <name>A0A0B1PHF4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHF4"/>
    <dbReference type="STRING" id="52586.A0A0B1PHF4"/>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="309"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="443" mass="50522" checksum="ECF12ADDEC6699AB" modified="2015-03-04" version="1">MSWKKSERLMETIKHYSGFPATGVSLRQMVQFGERPSVGTLFRASQFLSEELPIRLAHRVQELQELPDGLNEMPSIEKVRDWYAQSFEELTSLPKPQLTKDIRDRLIRPLNFNPKKSKVLSEVTQNPSIKSGQYSSSPWQNTGNSNGCQNDVKKTATTRRYFAIVDDSDSWPPELYDYNRRFGSTLNSIKRRHDSVVTTVAQGVLEYKRKRQRMLIDNKIQAFLDRFYMSRIGIRMLIGQHIALTDQSHASDPTYVGIICIKTNVRDLAEEAIENARFVCEDHYGLFEAPKVQLVCPPDLNFMYVPGHLSHMLFETLKNSLRAVVERNGQDKINFPVTKVVVAEGKEDITIKISDEGGGIPRSAIPLVWTYMYTTVDKVPNLDPDFDKNDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXL0</accession>
    <name>A0A0B1NXL0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003224">
        <property type="protein sequence ID" value="KHJ31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXL0"/>
    <dbReference type="STRING" id="52586.A0A0B1NXL0"/>
    <dbReference type="HOGENOM" id="CLU_390389_0_0_1"/>
    <dbReference type="OMA" id="RRFQLKF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="707" mass="79422" checksum="5E3F754AA52D4FBA" modified="2015-03-04" version="1">MTSQVPNPIWASYPLVKFSHHTGPNGIRSYNWTHINYRNDLEFTLRDVRVVDESGNHETRAWLKVTGGVEVLESQDLSQLVNFCQEFSSSIVGEHPIDIVVKSPFLAMKYPKTTETVRRIQVKFRRESDFSQAVQMLMKLGLSVLDKDIQTSALAVKTAIPTPESLESSAFNASTTLARSSPINFISVPENGDSCRASKPSPAKTVSNHSIVHSKLSGDFRNAPRVNFSTSGANRSFSYNPTGSAMVATSSMYQTEAACQSTFSSQNQTEYQNRHSSQLIIPNLNLGGSEIQKNTNLQFSSTQPKEDKNTYLFEDRRQPLEQSSLSWSQIDYGNSWEPQLIDNFSVKTPPGSLESAVSSSAQIKNIEDQEIRMPPKRILPFLAPRHNDENFEIPAKNLPPLPKPTPVAKNKINQPRSINVTLRSETIKKKHKKIVRKESKVVRDNNLTQRENNSSLESKSDDESTGTLTAQESPNLSKLSKKAIPVKKNPIIKKRSVRNQQEKNKRPKMKNQGTQTLNFMEQNYISASENENFRNSKTSSQGKSVSKGLWHTTRYDEADDETRYSLIQDFICENLENQNFLQLCKDIEFSWQRICLDALGVSLFPVRPTPYFNCIFILCSESKFPVKTLGSIGDQVPAKSKSSPSRGAGVNAQHALHVWDSQEDSHNHSLQDLPFIPAGLNRLRFYITFPSALFFTKPPTIGPGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXU7</accession>
    <name>A0A0B1NXU7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g5947</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003122">
        <property type="protein sequence ID" value="KHJ31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXU7"/>
    <dbReference type="STRING" id="52586.A0A0B1NXU7"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="204"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="286"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1172" mass="126719" checksum="1CA852AE42E7169E" modified="2015-03-04" version="1">MVNKSHNSAITGRTPRSSLNFISTKMATTTLRIGGMTCSSCTSAVEGGLVGQNGVESVSVSLVMERAVVVHDNSKITSEEITKIINDRGFEAEVLAIDLPSPIYDKYRHVNNDVHRNNYTTTTFAIKGMTCSACTSAIEAGVKDKPGVYSINISLLSERAVVEHDSSSLSSDQLAHIIEDRGFDVNIIESINSSIKEIPEICTHTTTIAIKGMTCGACTSAIETGFKDIGGIIQFNISLLAERAVVLHDPSKLTSEKIIEIIEARGFEAQIISTELAYLNNNNSSKRSLLKVFGIKDPASATSLENMLISLNGVNSAKINLATTRLEISHVPNLIGLRALVNFIEKQNYSALVSENDDKNAQLESLAKTKEISEWRRAFKLSLTFAIPVFLISMIIPMFLPALDFGSLLLVPGLYLGDVICFFITIPVQFGIGKRFYISAYKSMKHHSPTMDVLVVLGTSAAFFFSIAAMIVSVIAPPHTRPNTIFDTSTMLITFISLGRFLENRAKGQTSKALSRLMSLAPSMATIYEDPIAAEKLAEEETLLTTSTNQTESDLANNNTSLEKTIPTELIEVGDIVILRPGDKIPADGYVIRGETHVDESMITGEPMPLQKRKGSSLIAGTVNGAGRVDFRVIRAGKDTQLNQIVKLVQEAQTARAPIQRLTDKIAGYFVPTILFLGLLTFSTWMILSHVLNNPPGIFMQENSGGKIMVCVKLCISVIVFACPCALGLATPTAVMVGTGVGAENGILIKGGSALEIATKVTQVVFDKTGTLTFGKMSVDNTKLTPQWQIDSRRKNLWWNIVALAEMGSEHPIGKAILAAAKKQIGLSNNSVVEGTIDEFEAILGNGVNALVKPSLSFEKDQYRILIGNVEFLEANNITIPKDIIKASEKVNSKALISNKLTSAGITNIYVAIDGIYSGIICLSDTVKDSAVASIIALHRMGIKTAIVTGDQRSTALAVARRVGISSRNVYAGMTPDKKQEIIKNLQSEGECVAMVGDGINDSPALATASLGIAMSSGTDVAMEAADVVLMRPDDLMSVPASIQLARSIFNRIKLNLSWACGYNIIGLPFAMGIFLPFGWHLHPMAAGAAMAASSVSVVVSSLLLKFWKRPQWMDELLRKDLLLGNEQQLKRVSKDSALSSVFSFVKNIRLPKIRNKVVKDGYVPLSNMELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXY4</accession>
    <name>A0A0B1NXY4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003092">
        <property type="protein sequence ID" value="KHJ31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXY4"/>
    <dbReference type="HOGENOM" id="CLU_143693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="110" mass="12154" checksum="7915A5FDFDC98BBB" modified="2015-03-04" version="1">MIRLGPEHEARKAGPFELRQKIQELVSDKSLVSNVWSVPSGVAILASTPAKAASIMQSKATIEERLGNAIVEQQEKWTTFVIGPIPKRVRCLDGMQDLMEVLLQEELATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY14</accession>
    <name>A0A0B1NY14_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003061">
        <property type="protein sequence ID" value="KHJ31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY14"/>
    <dbReference type="STRING" id="52586.A0A0B1NY14"/>
    <dbReference type="HOGENOM" id="CLU_097996_0_0_1"/>
    <dbReference type="OMA" id="NWPTLIQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19031" checksum="DA172B236C75FF57" modified="2015-03-04" version="1">MAAGNAEPTSPLRVPKSVSNYTASTIDSEIRSSVNSRLLVDGHIPKIHDALLHALHASPTNWPTLIQSHALSLLRNGECTTFHEVLERVLEDIHVDTVIARSSTDPTPHLSSNVHSVGEKKSEYNGNKNLRKAEVNTSKNQEARQSLAIPPNVVEEGIRIVRECLETMCEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY15</accession>
    <name>A0A0B1NY15_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g4762</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003544">
        <property type="protein sequence ID" value="KHJ30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY15"/>
    <dbReference type="STRING" id="52586.A0A0B1NY15"/>
    <dbReference type="HOGENOM" id="CLU_023309_0_0_1"/>
    <dbReference type="OMA" id="NLRQPYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="16">
        <location>
            <begin position="290"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="67748" checksum="C32D0098E08E5E83" modified="2015-03-04" version="1">MLSRAIIRSVFTSRITEFRVHPACVREKFSKRWRRPLTRTNHPNNNEKFFSLGSMSLETTNGNLKKVESSRIDQDSKDKTEKSPTDISSNSIVEEQSSAESIDINNRSEEQIEIPPKLDEQKTINSPKNDSNSSNIKLSSTPDPRKEEEYTLNYPLPDLTQGIPSLLNYEARKKYTSSDLNTLQIEESLQNGGYRDRGSLPASAYISSSEKKRLQVANFLYGAFFIFSVFGTLYLGRNWDTKEEENEHTQAPSGWSIGLMWKRAKARISDELNYYQAPAFRKLLPDVDPMFERPYTLVLGLEDLLICSEWTREHGWRLAKRPGVDYFLRYLSQYYELVVFTTQPSHLAEPIIRKLDPYHIIMWPLFREATLYENGKYTKDLSFLNRDPSKVIILDTDKAHVKNQPENAIILEPWRGDINDKELVSLIPFLEYIPTMAYSDVRKALKSFEGKYIPTEFARRETIARKKFQEQLEEEKKRRPKRSILGLIGDTLGIKYQPMMFDPNEQSPAEAFAQGKMLQDQARERGQRNYQILEREIRENGEKWLKEEAALEEKSKEESMKALKSGITGFFGFGQNSDSESKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYP0</accession>
    <name>A0A0B1NYP0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003256">
        <property type="protein sequence ID" value="KHJ31098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYP0"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="239" mass="26250" checksum="E59D3F7540E084FD" modified="2015-03-04" version="1">MVSMHIQTTTVLSNIDSTLANLDEDIEKEEAESFKAYLRLAISNLAATDTSPTPPRVPIHTRPNKGNGNVKGKEIDRNLTKKVAVATPRIILTQVPSREINKNPELPKTPPSGDNSWATVARKSQKKARINLSTTARLALLGKTSHCSNNKDKSENPTSSTKAISDNRLFLRLPQDHEWRKLSPAGVREVMVKKLHISPSIISRIKPVHSGFALSPSNSEAREKILKAENGLFLSGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ93</accession>
    <name>A0A0B1NZ93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004465">
        <property type="protein sequence ID" value="KHJ30330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ93"/>
    <dbReference type="HOGENOM" id="CLU_1511708_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="178" mass="19417" checksum="428AEC0073755EDC" modified="2015-03-04" version="1">MSAIYTARSIGTNEKSTPLFTLKGLVNYAPSTITNLTVYGVPLERQVAYAQYASNIASFIAATDRRQVVTISPKPLGLLTKSLHLPMTPPAVNFTLIKPLPSDRSDKFISRLGPGAGKTQSGKTTIYQAPAIPDDILPTINLLSTPFFNAGRDAVNPKVMLPYKRSKYNYKKVRGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ98</accession>
    <name>A0A0B1NZ98_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative inner centromere protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004449">
        <property type="protein sequence ID" value="KHJ30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ98"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ98"/>
    <dbReference type="HOGENOM" id="CLU_003318_1_0_1"/>
    <dbReference type="OMA" id="PVPKWAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="790"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="835"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="940"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="859"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1226" mass="137704" checksum="B4BEA3A1CCDEE027" modified="2015-03-04" version="1">MILSKGHQSKRHMTGIMAGIRGNRPRAGSPSWISQERSCALQIVQSETEEFTYSVRNEVDWLNEHMAEIFNANHVSVAEMFKTPGKLRGKTPRTLRKNNHFLERPPLSSIFSTIPIELASNAKKISSGNPQPTFEVAEDQHVQVDSQSSKTSYQISTSQSEENNLPQQGNDDRPTSEYSSHRSLSTQLTEPDKLIQISNVDSNKLVDSSGNFFQEGSQINFSRSSEALNLQASPNSGKPNDENRVNKLGVIDEKLIPNSGIPKILELNRTSSPQKSSPRCLSEKKSLIHQKILQQQDLSSSPVIEPIENELNDVNSQSDGSSPIRLIVRKSSLNFASLPAREPLTTKKSIGNSVSRLSQLDLPRVSHFGRKATTKSTEINVNEEDVDSEDLESKEIGNEDSDSSMVRLQKKISTQRLQEKVTRLNGSSKNSRKSNSSDSTVQLHFAEIDQELNSTNPSNCERMSLGCENELVPNDYNRNCAGNSVDTLKHTSVSPRQELRALKNNNFVSKNNYEKSIDESSLHTLTPKPINTDVVENNIENHVNFVSPLTRTSGQSFEERRLQDNKISITKGSSKDSPQPIEISLKPTHVQKFAPSEQYETIMEAKKLGSSKEIKESNQMNLLLEKARLKVREEAHFYHLEQERVTFMQVEKTSKRSHEKELDGCKSDVTRVTRNSPRKVKLPTEAEKADTTPSVMEPPKKENGKIDVFNEIPPSAVCPKSQVGRQDKKRPLKPTRDISKTKPPTVIKVDIGSQRGQQHHLSNATLSATLQDSLSCQTNVAPQSLKHKASISSIHSKSSSSSFKSAATKALEAAARKKEKDQLVAARKREIKLENERQRILAKEEEQRRQQEAEYQAELQREKEKSVKLSETKKAASRQAIEKRRLEIEKTKESRRAQTGIRNKVATDSEKVLSTSSKLDTGQLRVQKIQQDTSRIVCSNLSSTTKLPPKRLFQHESEDQHLRPSIQRNGTSIFQNEQYSKRRKTTESDGDGDSENDRPKMTAPPVRQSSIRYKDMPPKSIFSHSHANNVASNNLQRSTLISQHNLIQSKPTHPLDMVQLAKGPIPFASIPSQGNQQPQKAPTNAAATKINGKPNTRTITKTITKSSPRYQNGENIDLPEIHTDSDDDSEDQPIGVRPGWTDTPEIQKQLEYQEIIDPAEVFGQPGPLNMEEVFSKSKDRFHKFRARTSSANWSGTDRLTEDEIQKDLEGRDRVRRQGGWTYDAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZE3</accession>
    <name>A0A0B1NZE3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nadh-ubiquinone dehydrogenase 24 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004320">
        <property type="protein sequence ID" value="KHJ30400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZE3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZE3"/>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="OMA" id="ERTMHYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="31780" checksum="39BB7FC424345AB5" modified="2015-03-04" version="1">MALKSNQLNTKLFSNIVSKKTCLSHIRTFRAGAIWRSDSLQVHRDSPHNNESIPFKFNEKNNALISEILKRYPPQYKKAAVMPLLDLGQRQHGFTSLSVMNEVARILEMPPMRVYEVATFYTMYNREPVGKYHLQICTTTPCQLGGCGSDAIVAAINNHLGITPGHTTEDGLFTYVEVECLGACVNAPMVQINDDYYEDLTPEGIVSILKALQASAHNIKASDSKTVENQTASDLKTKNTVQKTLDSTNIKPPTPGPLSGRKTCENLAGLTNLISPPWGTEVFRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG0</accession>
    <name>A0A0B1NZG0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002983">
        <property type="protein sequence ID" value="KHJ31338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZG0"/>
    <dbReference type="HOGENOM" id="CLU_1455422_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="21062" checksum="8173BFF2C54D9BAB" modified="2015-03-04" version="1">MILRIFLQQLLEKPEPDLSNKENSHEWTLDEINAAADSFSIAILSPKLLKQLENNSSLENKSELVDNKIKNKNEIKSEYLTPKSPPTHISIDQIPQIVDQDNNLSISRQSSQCFLTKYNKEIANLSKSYEAEQKYGGTGDNIDHKITIFYHLCARNGIPEEAHAMALSVMLKDFALDHYSSANLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH5</accession>
    <name>A0A0B1NZH5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002957">
        <property type="protein sequence ID" value="KHJ31358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZH5"/>
    <dbReference type="HOGENOM" id="CLU_1403378_0_0_1"/>
    <dbReference type="OMA" id="SSDIIMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="194" mass="21431" checksum="C2A9ED8E400084F5" modified="2015-03-04" version="1">METLHESLNRIEVLLSSEENTIENLHIRLNLIPRNETLLDTDGSRLVNGNSGGGSAIFQIGRQINIDAFPLRVNIEPFDTEVLAALRGIQTAVSLPTTRFARDLWGSVDNIEVARKILTKSSSISSQTTSFDILGASQTWKACTRFPHIQEGHIKRGWVPGYSGIKENELADKLGKQGAKLPYLDKLKFSIASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM2</accession>
    <name>A0A0B1NZM2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dedicator of cytokinesis domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005041">
        <property type="protein sequence ID" value="KHJ30126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NZM2"/>
    <dbReference type="HOGENOM" id="CLU_000595_0_0_1"/>
    <dbReference type="OMA" id="VECAEHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="596"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1462" mass="166552" checksum="AABC85E40E5D002B" modified="2015-03-04" version="1">MPWLPLPQIAFAVAIYPFTAQDPADLPLELGDELYIIEQSGKDGEWYRGYLLAPPSLLVGLTTSKGQTLEARVFSGIFPRSCVEIREILGDDDSEELELKLLSLDLETGLFGEDDIIQEIKPLTLSKSKSSHSKDSTKRKTWKQTSIINKHFSAQEIRDPTLPKPPAPVPMLKIGDETPTCIEQPLVDEIASCLREWQSTHLHRLLLAEDYQSLDKMASLVRNLDAARKQLLYGFLTKNELIKLQEKVVWDLVRGNKMFAGEVIVRDPSERGRILTADDSIIDVTQLQSIMSLLDEKPQLNVQEKPKFYHLLVEVKSFVGTSTENTTLVIFLASKAADQPYEVLSENYIIEVPPTRALASLAKTEILRTLFVDLTGADFGELNTAKNDLYLVVKAQGKQHISESLPKEKRFSRDGPPFERLTPQTSNTIGMSGLKSLILAGKVQRNTISRHLPSTPKSFRSSELRRSLSKSRDGSLKSFKTSFYNVNETSQSVHKATRIGAFKINDIIDRQEEYELVMNMWAPAPEYRESIVVDLEEVIRESNNFENSERTERLQLNIKPFNHLNSEALIEASPTLLSNVVITKMMGFSGAPMRPRSDIYITIDEAFLPRQPFLSRAIGNTGSFISLPQNICGLNLKVTLELRNNNGERLEDCIFSSSNSEPQSTWESIAVARGDSWKQTLRLAIPESDVPTSHLFITITDVPYGPFAVCYLPLWEQQAFILNGHHSLLLYAYSEIKKITKRNQNKVEYLSRPWDSKEKYKVGKDEVKTGQIATLSVKTNLCSTLFLQNRILLDLLKWKELPKLQVQELLKRLVFVPEIEIVKMLNDIFNAIFGIFVDQAGNKEYEDSVFGALITVLGIVYDRRFNIAPLVDQYAENEFNFPLAMPCLARSLTRLLAKPSDPDMSRQLRATFKVVKYILKFITRAREQQKETETAVTVTTTKATTSFTRDLRSIFKALDAMMRSEAPILIGSKTLAVQYFHTWLPELHGLLSKEEIVHVAIDFMDSCSAVKGKLILYKLILIINYSKLDIFAEKDQRKALCMNTVRWIEPLWEKTEEVEGQWRDQLRLCCSVVASQVQDLVNEIPDYIPKIIYSFSQILNNGHSLLSPEDNMKFSLLFPTTYPFPSKPILRPKKFDEALLELSAVLSAVSMRPAGIQLELAADEMAKILQDTLNVQLNILNCEAFPAGWLSVYIYHHKSTIKTLEYIGGILLDSFIPDPDDAEQYNTELWKTFFMVLLKLIRSDILALETFPEQKRRAVWKIAGDIREAGAELLQIIWEANGWETTIEEKFKYGLSKVGGYQVQYVPYLISPIIELCLSVHEGVRKVAVDVLRTIIVSEWNLNEDISIIQTEMIECLDRIFRSKRITETILQKLFIIELEQLFIPLSKFRGDPLYTATQELILKTSEFLDLLVAVYSSETVSDATHLINYLRLIEFLRDMQKEDILLSYIHKLAQLQSIRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN3</accession>
    <name>A0A0B1NZN3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005461">
        <property type="protein sequence ID" value="KHJ30049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN3"/>
    <dbReference type="HOGENOM" id="CLU_1662111_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="159" mass="18114" checksum="B49EDFC18C9B7012" modified="2015-03-04" version="1">MKIHQQPLRHQKSPQFLTELTSTSADLNSVLLQSRPDNDTTNATLKIKKNLSSSIKNPIDNEIHLLPRAKQVERPYRLPELPVHLPPPQPITEPNLTKISHPGPNVMPQADFNQSINLLQYNNIAIPSIDKYNGQTDILEYLEDFETRFALLPQVYSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZU7</accession>
    <name>A0A0B1NZU7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002830">
        <property type="protein sequence ID" value="KHJ31508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZU7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZU7"/>
    <dbReference type="HOGENOM" id="CLU_145563_0_1_1"/>
    <dbReference type="OMA" id="NQGGEHN"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11146" checksum="49DAC593E4B37BF2" modified="2015-03-04" version="1">MQRQLISRSFKLKSSFYAALSTTARPMAAGDTGAPKSGGAQSGDAFSRREKANEDMAIKAREREKLLELRKKISEQHDHLNRLEKHLDDLANERGGYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV8</accession>
    <name>A0A0B1NZV8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004830">
        <property type="protein sequence ID" value="KHJ30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV8"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="18452" checksum="C6E9CB690AF96300" modified="2015-03-04" version="1">MEISQESLAPTTDLSHQPSPIPPVPPIPNPPPPIASTSPPSQTTPNNMSTDRQILKPVAPSKRPIPDRPRHNSRNNSDIANAFLPQELADIIATRQRRERAWHARLMICTTVISSIDSTLATFTKEVEIEEAVAFKAYLKLAIANFAAVDSSPPPPLKGKVKRKVCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P010</accession>
    <name>A0A0B1P010_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ctd kinase subunit gamma protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002763">
        <property type="protein sequence ID" value="KHJ31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P010"/>
    <dbReference type="STRING" id="52586.A0A0B1P010"/>
    <dbReference type="HOGENOM" id="CLU_051552_0_0_1"/>
    <dbReference type="OMA" id="DMGEDLH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="28618" checksum="D53643EBFAF90958" modified="2015-03-04" version="1">MDPFEVRIRFTGLIVNLNASVISATKAAQYALKHREMDEDLHSCIIEQLEMPRNTMNNKANIMYFVEHLCDMAAKEKHVDYVRMIQRDMVRIVDAVAPEDGTGAANIKVVRKVLQALGMKGYLQAQTVTEIQELLKERDTASTEHALLSPQPVETGPKHAPRALSQQKIDRKVVEQRIEEDRERHKRLRESIWAIPTSLDQENEAEILWENTSDIGEDDYVLYSEEAEERMLCFANWKRDGTKNIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P057</accession>
    <name>A0A0B1P057_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0831</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002728">
        <property type="protein sequence ID" value="KHJ31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P057"/>
    <dbReference type="STRING" id="52586.A0A0B1P057"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="131"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114626" checksum="878EBE4D9E6F5EE8" modified="2015-03-04" version="1">MDDQYDEFGNFIGEAEDSDDESLNNIDANAYIYDKDDAEETLEDAGHELMEVDDDGPSNAVILHEDKQYYPTAQQVYGEDVETLVQEEDAQPLTQPIIKPLENKKFAIQETDLPPVFFDREFMMDLMGFPDQIRNIALAGHLHHGKTTLMDMLVMETHDLAGRLDKKIGKRRDENLRYSDSHILERERGISVKASPMTLVLHSTKDKSYLFNILDTPGHVNFVDEVACSLRLVDGVVLVVDVVEGVQINTEQIIKHTLLEGLPLILVVNKMDRLILELKLPPNDAYFKLKHVIEEVNTVIENTLPGQGEKQRLSPEKGNVMFACCSMGWCFTLQSFAKMYADSFYPKDNSSSGINVHEFAKRLWGDIFFNPQKRTFTRKGLEERSKRSFVNFILEPIYKLYSHTISDSPEDLKHILATLGITLKPSQYKTDAKVLLKLICGQFFGPSSGFVDMIIDHVPSPANAAMSKIERYYTGPLNTSLAKSMIDCDQNGPLIIQISKLLNTSDAKNFRSFGRVMSGTARPGMQVRVLGESYSIEDEEEMTFETISNVYISESRYDILTEGVPAGNWALLEGVDNSIVKSATLVPTQLSNNEDVFVFKPIKHFTESIFKVAVEPINPSELPKMLDGLRKINKSYPLITTKVEESGEHIILGTGELYMDCVLHDLRKLYAVMEIKVSDPVTRFCETVVDTSAIKCYAQTPNKKNKITLLAEPLDDGIAEDIENGKVSIKSSNRIIGKFFENNYGWDLLASRSIWAFGPDEIGPNILQDDTLPTEVDKKLLMTVRDTICQGFSWATREGPLCEEPIRNTKFKIMDVSLASEAIFRGGGQIIPTARRACYSSFLMGSPRLLEPIYSCSMTGPADSVTSLYTVLSRRRGHVLSDGPIGGTPLYRVNGLIPVIDSFGFETDLRIHTQGQANVSLVFDRWNIVPGDPLDRDVIITPLEPASVQATARDFVLKTRRRKGLSEDVSVAKFLEPEVFSSLMESGICCNTTLGFLASKVEKSSFTFTRCRCKRPACSACLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P093</accession>
    <name>A0A0B1P093_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004659">
        <property type="protein sequence ID" value="KHJ30249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P093"/>
    <dbReference type="HOGENOM" id="CLU_1355550_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="22116" checksum="79F034A3296B554D" modified="2015-03-04" version="1">MKIDPHLAQFLTEVFKSKKSAETFQQLDKISATFVEGCAILQWAELAGIQYELALEGTDFLSNDGGVANQLKSIVDYGSVDVVLHYEMDTEENPYVEFGRVHAPMLAVPVEAPPGAAFLALDQRKRTVGTLVTDSMESGTKMRILEVSPQSHKLCAIAAIQHAEILTAGLNARSMGDNEAISDRDLSEHFAKIVLNTKHNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0A4</accession>
    <name>A0A0B1P0A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004559">
        <property type="protein sequence ID" value="KHJ30296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0A4"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="177" mass="19772" checksum="9600BA640957ED93" modified="2015-03-04" version="1">MYGGNKLEAPHRTWLAYFTKAPRGGFRVFDESGIMRPYRKQQPLEFCKRCNGHHPSKNCSRAPSCANCGSTNHIADICMAATKCRNCGGPHRANSRRCLARPTRSGVPSKEQMKTYRQMGEREYQAVQRARIAEEKAATVDRIETDPLSSQASEESTICENFQATPVEDSTAVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0B0</accession>
    <name>A0A0B1P0B0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002359">
        <property type="protein sequence ID" value="KHJ32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0B0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="136" mass="15192" checksum="7A719B7F6DD26494" modified="2015-03-04" version="1">MAYFSKSPRAGFRVFDESGIARQFKKQTPLDFCTRCNDHHPEKNCSRASSCGNCGSTNHSEELCMATTKCRNCEGPYRSDSRRCLARPTRSGVPTKEQMKTYRQAGEREYQAILRAKAAEESAAPVDNLNSDLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q6</accession>
    <name>A0A0B1P0Q6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Duf1740 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003527">
        <property type="protein sequence ID" value="KHJ30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Q6"/>
    <dbReference type="HOGENOM" id="CLU_007550_0_0_1"/>
    <dbReference type="OMA" id="MRDKELH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1052" mass="123527" checksum="13D5FEA045BCB2F0" modified="2015-03-04" version="1">MPNFRNIEIPKFTSYKPKSTLQPQIHIESKTSNESKTKTRTHHKQIGRRTAENYNDDRTNSRKSSSKKSNLQSEHLNDSSYDSFVIDRKGDQNNLIYGSLHKYSIPKYYRYGAGRVLGAPLNLKINRELGDDKWIELSQSGLYENQTREKYIFSKVERQKPVVIKAEPQLLDKERITAEFDFISFYSNQNRSRYNNEETSEDENSTSKFETHDCYSDYVSGKQNLELHASQYIDENLTNRRKNATLRMRVENSPTDIEAWLLLINHQDLLIEKSDDPLRISQASIKSIADIKVHLYEKALQHCKSLENRERLLVGLMSEGEKLWELKIQANRWEHISKNNIDSLFLWKKYLNFKQFNLSTFRYEEVKKLYLQRIEYLNETIKTDPKYTEKNCKELLFVLLRATIFIREAGYSELAVAIWQSNLEINFCAPREEYKYDECINIFREFWESEVPRIGEIGAKGWRYYEENPDAISAINISEDKDGDLLEKSNIFKSWAFAERLRSRSSKIPAKTLDEVVDDDPFRVILFTDIQDFICFLPSKSEKTYRFFIDAFLSFCSLSPLVNFDDDQKYDYNDIFNIDSFVESEHMWLESDCSSDKKDTKCGNQDATIAPTPNFVSSSDSLFYDITKLHETLRPYRARFPEDTGPVTYNFVRNSLSQLIHNFNDSALAEYYLSFEYKNEPDTIKKISKALLKQNSSDLRLYNAYALIEWSSGNKKVAEGVFSAALNISDSNARNFTDGKIILLWKSWIWTCLEDRDNFKALRYLICIADGQPNLNFDIHPTVLLRTKQYLTLKQDYFMSINSVIAVMYSECLALLEYLSSFPRQDTSLELQGNIKNALKLYTLISQILHENKQRKSHEILLQSASRLLFYHCRCGSYSPAFVREYLSDFLQKFPQNTIFISFYSWNESRLRIDDRVRYLLLKNVLLPQNDSLTSRLFAIRYEIKIGNIHSTKAAFEDSVSSPIMRNSPGLWQLYILYCLRIPQFQCDAKSVWLRAIRNCPSVKKIYTLGFEKLGECMEYLELKRIWKTMEEKELRIHINLEDEFDEIEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S5</accession>
    <name>A0A0B1P0S5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g1785</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S5"/>
    <dbReference type="SMR" id="A0A0B1P0S5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S5"/>
    <dbReference type="HOGENOM" id="CLU_007713_2_0_1"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="242"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="603"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="756" mass="83349" checksum="1187D2F23169F37D" modified="2015-03-04" version="1">MGRAFLPDHSPKLPIASPPIETASNVVLIDNFDSFVWNIYQYLRLEGAYVTVYRNNEISLKELVDLLPTQLVISPGPGHPRTDSGISKDAIAHFAGKIPILGVCLGQQCMIDLWGGDVSYAGEIFHGKTSPLQHDGKGVYQGIPQGVLVTRYHSLAGTYQTLPECLEITSWVSHNGNDSKKGTIMGVRHKEYLIEGVQFHPESILTEGGNFMLKNFVHLQGGTWAENDKLQKKNDSKKENILETIFAHRKAAISLQKEMPSLRPKDLQDAYDLGLAPPLISFIDRLTKSPFPLSLMAEIKRASPSKGLISLSINAPAQARAYALAGASVISVLTEPKWFKGNIDDLRNVRLSLEGMINRPAILRKEFIFEEYQILESRLAGADTVLLIVKMLDEKKLIELFQYSQSLGMEPLVEVNTHEEMKTALKIGSKVIGVNNRNLINFEVDLETTNRLLDKVPEGITICALSGIKGAKDVEAYLKNRVSAVLVGEALMRAQNPETFVQGLFKESKPKKKTSQIPLLIKICGMRNAEVAAEAIKAGANLIGIILAPGKRRSISPEVAMAISSIVHRSRSLSDSRSRSMISNRYENQASDFFENSFLHFPRDYPLLVGVFQNQPLSEILELQKLYKLDIVQLHGNEPLEWARIIPVPVLRSFLPGQPSLRTRGFHILPLLDSDSGGSGKRLCMSAVKAVLSKDSSLRVFLAGGLNPENVKDVIEEAAELAEKIIGVDVSSGIEENGIQSIAKIQAFISASKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T9</accession>
    <name>A0A0B1P0T9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0T9"/>
    <dbReference type="HOGENOM" id="CLU_402354_0_0_1"/>
    <dbReference type="OMA" id="CKSACFE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="684" mass="78032" checksum="5CE13D075EB67BF0" modified="2015-03-04" version="1">MSTTNTNKKYIRRRRGACDSCKQRKVRCDGETPCAACHRSSTTCRYQLSSTRSKHAAHASIDGEISQSRRPPSLLLNTVLSPTWDSHEDFSSFTPVDSGWPSASWRGDISQNIVFSPDIECFEGVNIDLDNAWQSIWAYPGEQVKQTHTQHNYGFQSPPQETHAYGAYTPENFVEQHSSALLTPSPERSFQHNADFSNDILEEASYFQSMYQSSDFSIKSLFSVPRISNFGKLEDQSIVLELLEDVRRRHWMLGRPPPFKKTLDFKFNAQAKCYINACFDEPLCVSLFLDKLFLNLVAQEVLEKKSRIEYHVTLIYAVLAIGCYIVKVEQEGDVKQGLEEAYGFFQVAEESQSTNFGTEISRENFLATLVMILFARKCGRDREISLLTTLSSIAIGLKLYSLKSIENLSDTEQSKIELQRAFWLYYAIEKPHALRIGQFSMIDDSFIDYQPPIVKLKYENPITVAQDEYYRDTGQEDLLLLQCRFAKTCSLITTKLYTPHGLQKTPSELYNSIFQLGGMLKHWKDSIHASIRPLDLSSASTFVPELCKASQEQLVLSYQYYEALWAIHGRWRLCNPSHMSDEDVSRMVTSRDLCLNVARMVLNLSSEFRISTLLSHWSISQLPVIASLSIFLDAIDLEMSCPKEKALPYLSIAEGFYGRLSTLESAPYKIILKMTSALRQILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0X1</accession>
    <name>A0A0B1P0X1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2678</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01003444">
        <property type="protein sequence ID" value="KHJ30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0X1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0X1"/>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="177"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="54647" checksum="03B95AD83672C9A9" modified="2015-03-04" version="1">MFRSALQRTVINSSRHILRSNPCSRIAGARFASDSTIHGKIHQVIGAVVDVKFDTEKLPPILNALETKNGDQKLILEVAQHLGENVVRTIAMDGTEGLVRGHRVTDTGSPISVPVGSGTLGRIMNVTGDPIDERGPIKYTKKSPIHTDAPLFTDQSTAAEVLVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETRVIQLDGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGLMQERITTTTKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLESKSRMLDPRIIGQDHYDTASKVQQMLQEYKSLQDIIAILGMDELSEADKLTVERARKLQRFLSQPFAVAQVFTGIEGVLVDLKDTIRSFKAIMNGEGDDLPESAFYMVGDIDSARAKGEKILAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P105</accession>
    <name>A0A0B1P105_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003899">
        <property type="protein sequence ID" value="KHJ30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1836608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="140" mass="16051" checksum="75953A0DEEEB19A6" modified="2015-03-04" version="1">MSDIQTQKTADINVYCSEDENLSDYDMGNTQPGQGTQSHDYEKSTQPTSSFTTAGFTTYRQQNVQQTTEEKFTMENIHTMLQELYKAITEKVVMENAAMFNALKLESTKIKKELEDLRXXXXXXXXXXXXXXXXXRMIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P198</accession>
    <name>A0A0B1P198_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Putative mitochondrial inner membrane aaa protease yta12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g2685</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002412">
        <property type="protein sequence ID" value="KHJ32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P198"/>
    <dbReference type="STRING" id="52586.A0A0B1P198"/>
    <dbReference type="MEROPS" id="M41.003"/>
    <dbReference type="HOGENOM" id="CLU_000688_23_4_1"/>
    <dbReference type="OMA" id="ARQKGNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="393"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="809"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="835" mass="92726" checksum="6C9FC19AE4EA1CFA" modified="2015-03-04" version="1">MNDQSPKNNVEEKNKTSKSSGSSPVPVQSDHPNDKNKPQNDSHNDEKVGKKHLLEGMTEMSDLDEKTIQQLIDNMKINMPKFQREIIENAFNAMKKKGIPEEMKELLEELRQRDTGKPISLANAMKFAKLATDIIKMTDSPTKTQESQSNTNGQRFRLNFNSSSARDFKKTKSGSKKSSSAEREFRLDFNTIAISAFVSYLIYKSVIPGESSRNITYQEFLSTFLVKGLVEKLTVTNGGKVRVDLHREATQAQYPDSPASNPNFHYYFSIGSVESFERRLDEAQDQLGIPVSERIPVNYASEADLWSLLINFGPTLLFIGAIFYLSKRASAGGGGANGVFGIGKTRAKRFNHETDVKVKFADVAGMDEAKLEIMEFVSFLKTPETFERLGAKIPRGAILSGPPGTGKTLLAKATAGESQVPFFSVSGSEFVEMFVGVGASRVRDLFAEARKNTPCIIFIDEIDAIGKSRGEVGSFGGGNDEREATLNQILTEMDGFNTSEQVVVLAGTNRPDVLDKALMRPGRFDRHIAIDPPTMEGRKQIFLVHLKKIVTNEDLDYLTGRLSALTPGFSGADIANCCNEAALIAARTSVKSVEMIHFEQAIERVIGGLEKKSKVLLPDEKKVVAYHEAGHAICGWYLKYADPLLKVSIIPRGQGALGYAQYLPNSDNYLMNVNQLMDRMAMTLGGRISEELHFDTVTSGASDDFNKVTRLATAMVTKWGMSKKLGTLHFEDNSDTSFQKPFAESTAQIIDSEVRRIIDEAYKKCRDLLTEKKDEIGIVAEELLSKEVMDRNDMVRLLGKRPFDENKEFEKYFGEGEKSTPPQASTQSKEVPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M0</accession>
    <name>A0A0B1P1M0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rab protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002304">
        <property type="protein sequence ID" value="KHJ32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1M0"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="OMA" id="IRYCDDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="205" mass="22451" checksum="4857BB1A4CBFF6F6" modified="2015-03-04" version="1">MASDESPPTLKILMIGPSGAGKSALLIRYCDDQFDSESSTATIGVDFKVKISVHGTAYRLNLLDTAGQERFRTLSNSYYRNAHAILLMYDISNRESFLALDRWFDEVEANAIPGAVTYLVGCKCDKASLGLRRVSSEEASAKAKIRGAVGWCEVSSKTRENVRRVFSEVVEAVVRDKELMKVGRRQTGVVSVVNNEIASGSVCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1N3</accession>
    <name>A0A0B1P1N3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anaphase promoting complex subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003686">
        <property type="protein sequence ID" value="KHJ30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1N3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1N3"/>
    <dbReference type="HOGENOM" id="CLU_787529_0_0_1"/>
    <dbReference type="OMA" id="VTHAENQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="364" mass="40013" checksum="B1DF180E5E6222AA" modified="2015-03-04" version="1">MSSFEASSAILAPNSNDQTSDNAARSITISPLPLLELPTRPKSSLKIAADHDKMNNQAKVGAQDTRKLDCLMKISNSDPSIVIDESTDVMKGLTDIQNDPSHEMEDQSTLDRPPFAPFFTLIKTGETIAHPRQVHYLFSDDDTSEVLTSTILQSLFEEASSNTSLINSVDSKGKLVPVISSKSSRAISPSISHRDTRLRKRENEFSFKGNDSKSGIRVIIVDLNSNGDGVASVNSLSSKWQVLNAQIEKAPTWNGTDDAKTEETCNTIGNMMLKIEGISSLDKRTYSTTLLEPEITGLGVLPSKGPANLSDAKRFPGEEEMQTFIEAFDREMAILRRVIGTRPRLDSQDTVVEISRDRRHAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P3</accession>
    <name>A0A0B1P1P3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002278">
        <property type="protein sequence ID" value="KHJ32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1P3"/>
    <dbReference type="HOGENOM" id="CLU_027966_0_0_1"/>
    <dbReference type="OMA" id="CHGRVQV"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="564"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="659" mass="74275" checksum="561ADB91C4377801" modified="2015-03-04" version="1">MAPEDIKSNRKVKDNKYIFNVGVKGRKTGLTLPELGERDEHGLEPMDHLFSSPEKPNVMDLINKRNDATLSDEEDMELGESSTPGPIEALAERKRLISRPPPPKSRSPIKTFLQSPARRNAVMGSTSSPVRGSVVESKSASRPGSVQRKLEFSRTATESLRNRIDKNRSKPKRRPSEYKSADLANGRHLNSTSATKSDDDEEIEDISFVERESIDHIEVAQHNKNESEGLSDESDKITEDEDQPIRANKMDKETTSRKPPRPKEWRNKFGEVRGSSFKDTGAEKQESLPKSHGSHIRVRENAVQKKKGSSRKTALNQEFNEENRRLHKRSRNSSDEISSSEGEVEKSNVQTTKTMKRLKKNEYKLSESKSTSAQLASSLSQGDSRPKGKRSATGNNKLTSNQSGPPLPKSRGLVILRREDDKILKTRSGRNSIRPLAFWSNEKIEFEDEELPIKDLTADFAGRKIKHVVRAEITEPVKKSRIKTHSSKVKKRKRAKVSASDDDDSNDDNDQDLEPWEVDPGRIIAEVRTWDQDDTSGSQIGEREEEIAVSSTAIITRDIANASFRFAKTLTLPFFGAGMVDLPPGSEKKQKNSRKMQMAFFVFYGKVQVTVNDNVFRISKGGMWQVPRGNFYGIQNDYDKPARIFFSQGCENEEVITDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q0</accession>
    <name>A0A0B1P1Q0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative vacuolar protein sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001972">
        <property type="protein sequence ID" value="KHJ32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q0"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="623"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="854"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="961" mass="108951" checksum="2F5F92835957AED6" modified="2015-03-04" version="1">MAIEYPQSKILETSTLPPIFNVERVQLQFSIASNLVAAQVANNVLVLALSSGRILRIDLNNPADIDDIDLPKKTEDVEIRRMFLDPSASHLIISTAHGENYYLHTQSRQPRPLSRLRGVLIEAIAWNPGLPTTSTREILMGTLDGNIYEAFIESVAEGYRKEDKYLKLLLKIPDQPITGLWVDFLDEMQHPVMGRALIATKYKLFHLVGKVGRLGNDGGTTVFSGLFERERMVEHEISTFPSPVVSKLVMSPDTLDFDSLDTSSPGRIFAWLSPQGTFYGPLITTPTTSELGTKLFTQAKMLSSSKLPSSESIGEQRKTAQDFVESIVLTQWHIIHLVGGRVICTNRIDDQVVFNQVVLEPGQQCLGLFADQKKNTYWLITTEEIFEIVVSDEERDIWKIMLKIENFEMASKYARSHSQKDIVATASGENLIQKGLFNEAAVILGKTSKSFEQVALTLIENDQYDALKRYLITKITTYKKSCIMQRMMIAGWLIEIFMSILNSLEEAVVIKTEDIEYPSPQKDEQLSTIKLEFQDFVMRYKTELDKKTTYDIISSHGREEELLFFASAINDYNFVLGYWMQREKWKEALNVLKKQKDPEIFYRYSSGLIIHVSTELIDILMRHPDLNPRQFIPAILNYNSNFDGPLIQNQAVRYLLHCVNNLKSTDPAVHNTLISIYASHPTKDESALLSYLVSQGEEPFFDSDFALRLCIKFTRVQSCVHIYSSMGQYLQAVDLALSHSAIDLATLIADRSLSNPPLRKKLWLAIAKKVVSQSNGTKTTIDFLKRCDLLKIEDLIPFFPEFVVIDDFKDEICTALEDYSRDIDSLKKEIDESSKTATKIRIDIATLDRRYAIVEPGEKCYTCGLPLLSRQFFVFPCQHAFHSDCIGKKVLEDATTSKSRMIRELQSLVLKDSLKGSAREKAVNELDELIAGSCILCSDFAIRKIDAPFISPNEDVSDWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1U7</accession>
    <name>A0A0B1P1U7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pre-rrna processing protein tsr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002237">
        <property type="protein sequence ID" value="KHJ32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1U7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1U7"/>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="86"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="807" mass="92026" checksum="42DED81C4FD6358F" modified="2015-03-04" version="1">MGPVSQVHSHRSTTKVTHKPFKSRKATKGFLKEIQKGKLDKATQRKNPHQQVMSKLDRRNQNRQKLLAKQKEHSQETKIFAGRNGAARIVAVIPLCVDSNAAAVVKSLSKSLDIITEVPDEGLCRVSIERFKQDIHYITVKRDLISCLDAARIADFIIFILSPDQEVDYLGETIIRSVEGQGLSTLLTVVQGLDKIEPFKKRAGILTSLKSYMIHFHPEQEKVFNLDSNIDCVNLLRSICTVMPKGIHWRDERSWMLVDEVLWPENSDDSVVLTGTVRGKGLKADRLVQVGDWGIFQIIKITAATSQLAKKNDDVAIDEKYEEKVLELPTQYQDDLLELAPEEINFQDEMQITDSAPIQEKRGVLLDDHHYFSDDESHIPSKPKRLPRGTSAYQSAWFLGDDYSDSGSDFEEIDEQLDVDMETQALPEDGNEGNSAVEPTEVAPTQYAKSEVFLDPKPDDESEIQQLAAFRSRKNEAEDDREFPDEIELHPKVLARERLARYRGLKSIRTSTWEEEEDRAFEPQEWRRLLEVQNFKSARSRVTREALAGGVVAGTRVRVYLRDVPLSLKASWTNSNYPLGLFSLLRHEQKQTVVNFSVSLSSDYPEPIKSKAEMVLQCGSRRFIVNPLFSQSGITKNNVYKFNRFLYPGQSAVATFIAPLTWGSVPSLLFKRVNNSDPMEGSELLQAPLNFVSTCTSLAPSTSRVIAKRIVLTGHPYRIHKKLVTVRYMFFNREDVEWFKALQLWTKRGRTGYIKEPLGTHGYFKATFDGKINPQDAVSISLYKRMWPKKSRAWNRFTDDKDIHMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Y6</accession>
    <name>A0A0B1P1Y6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003024">
        <property type="protein sequence ID" value="KHJ31285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Y6"/>
    <dbReference type="HOGENOM" id="CLU_036943_3_0_1"/>
    <dbReference type="OMA" id="AHYCEIT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="453" mass="50298" checksum="2F1C543E745EAEB7" modified="2015-03-04" version="1">MNIDTASELDLESEIESESEIDEFPPLPSNPSLKRTSEALSPTQGSDYTKDTFKDNHRSQNSTLMTKARGLLNLVGPFLEEMETDCPGAGAGFLALISEGVSRAIRGETIFLRTTTDTEIMPNSSANKKNSWAARVANGQTSIVNNPTPKPRTKPTPPQGQSHEDRRVMIRLEHDHEARKTEPFLLRQQIQRILPDPSLVADTMQVPSGIAILAPTPAKAAAILQYKDVIAQRFGKAIVERQESWTTFIIGPLPKQVTTMDGTEDPLDGLLLQEPGLISIRDEVQIKKIAWTKKSQESSDLLGHIRIHIPETKAHKFPSRLQLFGFAVGIQRIRDRKPIPTCEKCHGFHSTRTCARQPMCKLCGTEYHEGSCAHPIRCLNCRGPHESTSIFCPARPRRKNGAIVRFSGAQLRHIRIAGRKDFNLAHYCEITPESTPESTPNETGVTESNFTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H5</accession>
    <name>A0A0B1P2H5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003548">
        <property type="protein sequence ID" value="KHJ30834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2H5"/>
    <dbReference type="HOGENOM" id="CLU_076902_10_1_1"/>
    <dbReference type="OMA" id="MSKAQPP"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="80" mass="8925" checksum="E2FD9D96FA17BA70" modified="2015-03-04" version="1">MPQPLPELKKYLEKRLFVQLNGSRKVIGLLRGYDVFLNVVLDDAVEEKEGGEKVKLGMVVIRGNSVVMLEALERIGGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2J4</accession>
    <name>A0A0B1P2J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative com1 regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003529">
        <property type="protein sequence ID" value="KHJ30859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2J4"/>
    <dbReference type="HOGENOM" id="CLU_013856_1_0_1"/>
    <dbReference type="OMA" id="KMFYPKY"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase UBR1-like winged-helix" evidence="2">
        <location>
            <begin position="240"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="665" mass="73140" checksum="3A9D5EF778591C6B" modified="2015-03-04" version="1">MSALVISGSGLDIKGFTTKSNNPTTTPKAFGISLSNRVIEDMIQCVRGGKTLQLSLDESPKILYGNKVQHFEVTDNILCHEIIRTSLPTSIRPQAKAAIPHPAVNTFTNAKMMSNVAAVVSQRLCPINSPVVNTAADGKPLPSAKESVRKNQDAAVVALQNSLATESLRKAENTVKYVKDVSLSMPSKRGIAKSSRTNISRHQSRTSNDFSGKTLPPSPSLNSSSVPLSQKQAEQAKAARKPVIHLLAVSPLTERELDAKIPESTTEDLKQTLDKVGDLNETTKKWELRKAFYKELDVWCFKYNCREDRQRAIDNAVKVFDKMRMNISEPQWEKLLPRSERGTGKCLSKLQAQIAQASSQKIPKNSEIGRDSPQKNNNKDDTMGEKLSNKVKGEPIVKTTSQGTTVKTKKAVKEREAQAKRLLSKKSSGAKSASIKAANSKKTQSVSKDVKSSTILSSEYVEMSDEEDTLPSVSTIAKNKKRFREKDEASITEQNISPAKKVKESSSFQNRSSESSRTTSTGQFSFSSKSNKSNSPQISSSLATSPPTNASDLQDSSDTQSLAATSPRPHLRTTPKSPICKANSSKSYSGRGSSGATTRRLRPEVTNLARRYKMFYPKYLELYEQLTSMGDRRDRKMEKDLLDMHSRLTVMKEKILAGIINVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P342</accession>
    <name>A0A0B1P342_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P342"/>
    <dbReference type="STRING" id="52586.A0A0B1P342"/>
    <dbReference type="HOGENOM" id="CLU_096859_1_0_1"/>
    <dbReference type="OMA" id="YETNKGA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="17548" checksum="46826ADF2D33EB9A" modified="2015-03-04" version="1">MPYFATSQEWLDQSALLIKARPTTTRITTKYKIPNLSSDSRSKRKRKDKVVVKDETKSLFDTTKTKKNETSATSVSPPATLTLKTYDPVSGVTLKYITHKAAEVSRLVQIMGRLGNVMAGLDINEEVSVSTETTESKPLVVETPSGEKKSKGKKKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P379</accession>
    <name>A0A0B1P379_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative major facilitator superfamily transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002951">
        <property type="protein sequence ID" value="KHJ31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P379"/>
    <dbReference type="STRING" id="52586.A0A0B1P379"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="OMA" id="CCMPLYA"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="383" mass="42709" checksum="7414E2BDE2503A78" modified="2015-03-04" version="1">MNPSRFIPITMIIWGLCMTFMGFVSSWSGLMAARWFLGLAEAGLYPGINYYLSCWYKRSELGIRAAIFFSAAAISGSFGGLLAAAIAKMDGIRNLTGWAWLFILEGTLTAILGIASLWLVQDFPDKAKFLTPEDRARVTQRLNAEKQSSVDHETFEMKYFVMALKDYKMWLGMAIFAGADMPLYAFSIFLPSIIHELGYTLTSAQLLSVPPYIFAAILTIFIGWIADRKRQRGIFNILTSSLGIIGFTMLLVSQNPGIKYAGTFLGALGIYPCLPNTITWISNNIEESYKRGIVLGFVIGWGNLNGIVSSNIYYRAPKYTVGHAVVLAYMTVFLLGGSFLMRYLLQRENKLRESRETSNSLSVLDSKTIEASGDIRPEFIFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3F0</accession>
    <name>A0A0B1P3F0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3F0"/>
    <dbReference type="HOGENOM" id="CLU_1817231_0_0_1"/>
    <dbReference type="OMA" id="HERRVKD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="142" mass="16598" checksum="54CA78AE78ED1419" modified="2015-03-04" version="1">MTRQRRKCVQISDSDNENKQSSAQDDNRDVIEIAHRIVRDTKNIRNKKRKGIEDDFNKQESELNVKIEKLFELRQAAVAKLQNDAWEKLEALNEKLQFIEGSILTSMTNLEFATLNMTKQMILVLRKSIHNHQEINFGTVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3F5</accession>
    <name>A0A0B1P3F5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative duf1682 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001557">
        <property type="protein sequence ID" value="KHJ33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3F5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3F5"/>
    <dbReference type="HOGENOM" id="CLU_042570_0_0_1"/>
    <dbReference type="OMA" id="FDGFVWA"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="433" mass="49317" checksum="646AD78EC71EBD5F" modified="2015-03-04" version="1">MAAILRGLFRDSKSSPPPVPISDTDFAEFDSVIPIKTETFLSSDTASTVIPSVVPYTKWYNIHERHSATEFVQEAIILAFLSIIIIVHLIGTSKNRKKVKNIVAVLGPSLHKEFGLLGFGTSPSEKNDAWNQEDVEDIIREKSPSEFASYATGRQNIAFLDININLLKRYSPLSLFVEAAMSVFFESIAAPTEQIEATIYPFDGKETLLLPKTSLAIGESRKHFNSNFDGFVWAIVNKDNLKNLRDDRYDLSLTSTKDNSKLPNWATIMSESSEITELLLTSELITAIEKSNEMLNYLIITDQPIDQPVKLEDTTPKKRIYLGLKIPSAGEYSCILPIFNYFLCLTDSLVQHAHFRPEISRKIRATREEAIRKILKSQEELKAEERNLEREKAKKLKRDLDLKALDSKAQKKYLEKEKEKEMRKSQKKLVQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L5</accession>
    <name>A0A0B1P3L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 40s ribosomal protein s14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002811">
        <property type="protein sequence ID" value="KHJ31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3L5"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="151" mass="16146" checksum="307D2B22E27C1DBA" modified="2015-03-04" version="1">MAPKKTSRPAQENISLGPQLREGESNVFATARIFASFNDTFVHITDLSGRETITRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARSGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M0</accession>
    <name>A0A0B1P3M0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003061">
        <property type="protein sequence ID" value="KHJ31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3M0"/>
    <dbReference type="HOGENOM" id="CLU_877133_0_0_1"/>
    <dbReference type="OMA" id="FMCASFA"/>
    <dbReference type="OrthoDB" id="3596195at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080454" evidence="2">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="27720" checksum="540629983E74C038" modified="2015-03-04" version="1">MKIKTILILVSLPITYAVSLSNFQRLPSSNIRKNCQDAYNSEIPFCLPTDFTEFCSSRCITGLYAIAEDVSNKCADSTVSANTLLGMVLSGAMVNILCPQPKLRLSKTSTMVPDLTSSTEKYGTETESLQYPIPTSTQDFDTTTSSLLTLTSQTLISGPKLTTLHLTLGPDNTSPTSISMVITTPQVYMTSQSEGANTITKTSSFQTSSSSKSVDSDTDSSGGGSPFDIQNFGSSATSPDKTSFCAMVIALIWACLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3N4</accession>
    <name>A0A0B1P3N4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002454">
        <property type="protein sequence ID" value="KHJ31950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3N4"/>
    <dbReference type="HOGENOM" id="CLU_135198_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="156" mass="17867" checksum="BA9D8B2942C405D6" modified="2015-03-04" version="1">MDSETNAKLSCEEDLINSFDNRKVVPQEDKYSVQKKILDIPPKPRVNPSDIDESHIIFGKRTRKRTEKAKNLEPGALIATINAFITGKAKELRRLHQSELPPPPSNWRVLKNHPYSQAFRNAMMVEYDALIAKNVIKKVKHANHMKPIVTVFKQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4I7</accession>
    <name>A0A0B1P4I7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras guanine-nucleotide exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4I7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4I7"/>
    <dbReference type="HOGENOM" id="CLU_002116_1_0_1"/>
    <dbReference type="OMA" id="EEVWERD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="749"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="927"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1217" mass="137780" checksum="B976E82A7BC0C826" modified="2015-03-04" version="1">MVKSATTEKINLESTSTNNTHLLSKAESNNIDNYPNNRTTRSSNLLLQTHITPPVTPMGSFENVNQLTIDCETKFPNFLRAIYPFNPTHAPADNAVTLEFNEGDIILVHTTHINGWADGTILTNGERGWLPTNYCKTYEPEPMRILLISFLNLWEQVRYNLGRNRNRFPTQELMRCILAGVRYLLERTQCLTKDSTLIEQSDKLRRIRRALLSDLSSLVKYTNILQEVPPSSNINSGELERSKLICRDMMLNAFRLIRRGARFLDVWNEEVKARPNFCPESIIHRMAPVTEETKTPPTTPEDLTLENTSYYQSYENLNRSKSSQSLNSVHKRTEPFRKEIKTSIDRISSGYFSPLHCSSTTQSEPSPVQQYSVTHGISSTVPVSQRQNFASERLNSSHDTLLSFLGSLIGRLHSQSQPPAEFISIVEQFVLAGQELLNIIKIICDHDPQSTQLLLLNRTVMQDRIHQLVKDARETISSNLDDEITIVSPTQKTRLLMDSTTCVKSAGECVAKTKFVLERIGDFEFEPQVFDSKTHEDSISELPCSYSQLPAENWTLPEVKNNVIEPPSSFPPPVPFTTPNYQKPLPEVPPKFPSLMEEDLSSFSQLSPLDTESHLSYCGTIESPSKGRLRVVPITTESNNITDDLLPLTTLSTQDDNSEVSLKKKSISTTNEGCNIMYLSSLRNSDTSMTSMNSTRATTPDQGLSVTQSQISYSEISLCSSQSLSMEDQEETESKLLEKTFAHELVFNREGGIIGGSLSALVERLTLNDSTPDVSFVSTFFLTFRLFVTPEVFASKLIDRSDYAGENSETSHIVRMRIYNVFKNWLEFHWCNSTDYTAISAIESYATSKLKKNHPGAGQKLINLLFKVSSANTRPNVISLLGKTSICVDQYLSTNLPTPNPIITKNSLSLLRNWKSGECNPTILDFDPLELARQLTICGMRIFCSIRPEELLASRLSKKSNPDAPNVKAMAAFSTDISQFVWDTILQQEDAKKRATILKHWIKVAQKCLELNNYDCMLAIVCSINSSSIIRLKKTWEAVSQRRKDLFQSLLSIASNDHNRSTLRQRQNNHAPPCLPFIGIYLTDLGFADLGNSPTRPLPAMGNREEQKVINFDKYIRMAKIISHIQRFQLPYRLNEVPELQDWFLTRFRSIRTSLNGADGPAYYYEKSKLVEPKDLHSSFRSPTETSFSSTYKEKFDIFSWVHKDRSSSIVQTLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P543</accession>
    <name>A0A0B1P543_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002606">
        <property type="protein sequence ID" value="KHJ31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P543"/>
    <dbReference type="STRING" id="52586.A0A0B1P543"/>
    <dbReference type="HOGENOM" id="CLU_002768_0_0_1"/>
    <dbReference type="OMA" id="SYMTIPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="817"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="953" mass="105041" checksum="187E556F12EB73B3" modified="2015-03-04" version="1">MRNPGETAFSATSPPIFLDLKMSEQLDMDPDFEFFDSTALDSANTPSQFVDDIGPDTTSQFLTNLLSPKNQNHFERTHSLENGCQPSLSTSLLDSPAGSYQDSSSESTDYPRKSSSASLTSGLTPGDIMMGDDTALMGRWKTMLNGDESNKLQGIIDGCINPSAVNTSFLNESNFDQDISFGSSASSPSFKAGISGTLSPEISTIKSSAPKQSIKLNKFKSEKTSTQHKVIPPAKRNTSATSREVSPLSAMMSNHDSSPTFFPSPSPCTANLCNKDYANNCIFNNETNIPKWAMNLEVFQNHGFPSSHSTQHINPMIAHSRPPMTYPLQSKLTIHPTPLKSRVETQIPIKMTLFPLPPGITKLHLPTHTISKPKLLAKPKLERSPDTLELHTSLVCTSAMLNPELRKRAFERAAASSSCNPISPKEEQEEICSDEDDENKPINGGEVKICGGCIIRERKRAARKKAKKMEEEESWQKYETQRVIVFNTHELKDWQVPSQYLPSELIGDHPEPYVPEGAMQVDAPMRIACYCRHQNEKTGFQVIFTLKDYQDNLIAQAITSSIMITDDHKTSTIPSTNTQTSGNNDYMSGSCQFSEASYDVGNPSVGNQNLFRTSYSSSDLHSMQQRSLSLEMPAPSSTGNSPRLSNSNSVSVTPRISRQTSPSAYQGPLSKKRKSSSGTKFPSTLAMTRLESADSNIKSTTTSTIPSPFTPSFPSFPGAPDQHFNLTNNMQNISSNLNGPPTPNSISQIYSQVNKSQSMENLVIQPMYNTPASAIMSRTSSPNEVRLESYQRQQAQLDQAVSNGFYGIPMNLNTHRPPTIHKMIPSEGPKAGGIEVTCLGIGFVQGLEVMFGDIKATTTTFWGETSLVCLLPPSPFAGNYPVTFKHQHQQQQIQPYALPAPKQQTLFKYVDDDELQILRTALSMLGHKMTGKMEDVRELARRIVRECCDWLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5C8</accession>
    <name>A0A0B1P5C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002299">
        <property type="protein sequence ID" value="KHJ32141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5C8"/>
    <dbReference type="HOGENOM" id="CLU_556909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="499" mass="59346" checksum="8FDE33568FC3DB59" modified="2015-03-04" version="1">MEFNDLIKKLPNELFLEIAENLYFEDLLRARLVCKSWYQSFCGTDICAHVIQKQSPLPLDYYFKRFGLDYAQLDKKMKDDWHRKFMIKRIRREHGIASKIYELNFDLTDVRINQFLYSEGRVAVCYRDRFILEDLYTRKQSIFEFPANTNQRVSSCPFLCGKFLIYSLRENTGGRPNHLLVIWNVITRRQYLIPLVQVIRSSIHHQNQVGMLGTDPGYFRRYLFFFTWDEENGLKTLLRVEYSEAPDEKNVIGSIFFHPIKKDVTFIVLFTRIDNMFDSLKYGTRITVHCFEAGQLIQTQQEMMYTSNKPEEYRTSRFNNNDQIYFFVREPPYGWVESRSRTQLPTRLEPPKKTLDETVYEHLIYDMGKRKFTYFKTHFHQTYSGSLFCHSSLIWNDQILIRARHADEEKLQVITLSKNLTNLWDGSLESSNESRSRPERSSILCGETRSNCRITQFECDDKLSVNSEIRVYGDDNFVVLKAHKMAKVWQFDDLPIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5K9</accession>
    <name>A0A0B1P5K9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001358">
        <property type="protein sequence ID" value="KHJ33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5K9"/>
    <dbReference type="ESTHER" id="uncne-a0a0b1p5k9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_2_1"/>
    <dbReference type="OMA" id="DMYTYAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005109764" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="31"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="590" mass="64475" checksum="A573ADE2FD8D94EA" modified="2015-03-04" version="1">MRLCLSFAVTVVTFTYSQALEARQSDWRVGQTVSTSSGQVTGHDAGNNNEVSEYLGIPYAKPPVGNLRFAAPEKFESNAPINATKFAPSCYATPGSNETATPEQLLKANLTSQVKEIQTIYTDNNQPSEDCLYLNVWTKPQVGERKKAVMVWIYGGAFTFGSTSITAYSGRNFAALEDVVVVSMNYRLNIFGFPAHPNGTYNVGILDQRLALEWVRDNIEKFGGDASRITLFGQSAGSASVDYHSYAWATDPIAKAYILQSGTVFSWGLPNSQSMASKAWFTTSKNLGCGDAFSPQDKLLSCMRTKSPDDIYKAFPVGLPGSILGPFVPTVDNTVIFSNYSDRKPANLPVLVGNNDYEGGLFRTEYVIKGIILTDTFWTDFNLNEFTCPSSDRANASLAIKAPLWRYRYMGVFPNLELSPYSGSWHAAEVPLLFNEMPKTSPSTPFEVYTAKYMRGAWSAFAKNPTNGLIEYGWPMYDPTKDTLVRIGNNNSEGSNLINPYRYDADCIFFNVSSTDPSQFGVYPDLGAGITPTGTFISSPTSGPSKSGPDATNTGMLSKPTDKSSGYKVSSIRPFLLIPVMLIANAVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L5</accession>
    <name>A0A0B1P5L5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g6492</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001357">
        <property type="protein sequence ID" value="KHJ33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L5"/>
    <dbReference type="HOGENOM" id="CLU_012965_0_0_1"/>
    <dbReference type="OMA" id="WACPFLL"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene cyclase" evidence="20">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="598" mass="69102" checksum="AD9AB6E12FC794CC" modified="2015-03-04" version="1">MGLDYALVHIKFTIPPAILLTLFYRPILNRLDVYKILFLILIAVISATPWDSYLIQNQIWTYPPNSVLGPKIFLIPIEEVFFFIIQTYNTSLLYLIFNKPLFHPIYLVNRCSVAFKSKKIILGHTVQAAILFLFIVAVVSLKRSVEGTYLALILIWALPFISLLWFLSFPFLLNLPLTNTVLPITLPTLYLWLVDTLALRRGTWTIASGTKLNIYLWEGLEIEEAIFFLVTNILIVFGLVAFDYSVTIIQSFPNLFPRSPELPSPMLLIRALLIDSRLYDQERIEGFKSAVKNLKKKSRSFYLASATFSGRMRIDLILLYSFYRVADDLVDNAETEIEAFQWINKLTRFLELAYSRHEKKQEKPKQLEKTQFFIQENFPQSTHLALQLLPTQYLSPEPFYDLLEGFKMDLEFLKSRNENSTRNFPIVDEHDLEIYALRVAGTVAESCLELAFHHSKSNTPLLQQIRLKNAGKRMGVALQYVNICRDIVTDAKIGRVYLPALWLKDEGITYDQILSQPSGPAIEKLRSRLLELAFKNYFNALSEMSELPSEVRSPMKVAVESYMEIARVLREGEYRLEDGRAIIPIWRRLKVAWKALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T4</accession>
    <name>A0A0B1P5T4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001081">
        <property type="protein sequence ID" value="KHJ34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5T4"/>
    <dbReference type="HOGENOM" id="CLU_463214_0_0_1"/>
    <dbReference type="OMA" id="HAKECAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="589" mass="57393" checksum="069BBC87651C1E08" modified="2015-03-04" version="1">MKLTTTITVVVNLSCIINARSISFNRNEKRDLSDISSTLKLKAPSLSSDTQETVKKILAGNKKSQNASTDAIKVTSVKGDTVTSIEVPQSLRNKLLDGVKKATQQKEISTLLDSITGILGGDFNNPNLSSVSNGAGTPQGSASVAGTSIQSSGGNVGQSCPCSCLCGSGMIPNESATNASSSIGSAGQLVAGKGVILSNGECGCTCDCPRASFSNAPGTPSPNNVNSPPNSVPTAATPPSAPDQALAPAQAPAPAPAQAQGQSPNMSEPAIISQQTPGQNPPAAAAPAQNPPAPAVPAAAPAPAQAQGQSPSLSLPAIISQQTPGQNPPAAAAPAQNPPAPAVPAAAAPVQAQGQSPSLSQPAIISQQTPGQNPPAAAAPAQNPPAAAVPAAAPAPAPAQAQGQSPSLSQPAIISQQTPGQNPPAAAAAAATPPSQENPAAAPAPAPPAPAPAPAPAPAPAPAPAPAQAQAQAQEQSGSLSQPPLISQQSPNQNSSPAAAAQGQEQSSGSSNTSVAANPAQAVNQPSAPKATPSVPIGALSVTSTPAPAQAQAAEEGLGNNPIDIQSFSLTSSLNLGNLAVKPTSVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X8</accession>
    <name>A0A0B1P5X8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative te1b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002194">
        <property type="protein sequence ID" value="KHJ32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5X8"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_2_1"/>
    <dbReference type="OMA" id="INEAECY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="30189" checksum="577B2985F566504A" modified="2015-03-04" version="1">MPGAEACDAEIFGAFKALVTAVETDRSNPIKLLLDCRTTVRALCTGQAKTSQAKIDMFLDLAQTCRDLEVKWIPSHSKIYGNVTADKLAKSALTQLPAESITNFDPSRPRGETKYSIAALTRYVRDQTKIEIKLWWRNHKPRRYRELELEMDHKQPPELTLPRWAYHRLVAARIGHGDFSDYHERFKHVNIDDRCVCGRERRPWHFAECRLAQRKWRDSEKSPVPSAKEMFREKGWLKFFHYINEAECYKTVFETENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P662</accession>
    <name>A0A0B1P662_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000998">
        <property type="protein sequence ID" value="KHJ34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P662"/>
    <dbReference type="HOGENOM" id="CLU_046558_1_0_1"/>
    <dbReference type="OMA" id="QTRCVQI"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="37266" checksum="1AB19FAC104ACD6F" modified="2015-03-04" version="1">MQRLSLLVSPKRCSFLIQNLSVALVSSRNIQISSTSVAECREDALLGDISSDPADAKFEVLGTPYSILSASLSASQNFYTQRGTLIGIHGKPENTRSKLVLLEPFRRSLLGIPFLYQKISSTSPTNLLISTKSPITSFTVLKLDGSIDWMIAQTKALVAWTGQSLSFSPVFNRGLGVAYWGTTKVTGRGLMALCGTGNIYQIQLRDGEEYIVHPGNILAYTISQQHPPQPYRLSNFRLYVPSMKSSAVIVDLKFIQSLRQSYIWQRLIYYYRIIRTFMRQIIWGDQLYLKFNGPMKILISSRATKIGDILTSQEINELAEAKSANPLSLEKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6A9</accession>
    <name>A0A0B1P6A9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative anion-transporting atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002241">
        <property type="protein sequence ID" value="KHJ32209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6A9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6A9"/>
    <dbReference type="HOGENOM" id="CLU_040761_0_1_1"/>
    <dbReference type="OMA" id="AMWFTID"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="243" mass="27061" checksum="B343681D602924CF" modified="2015-03-04" version="1">MQELMGQAEESGGGGDTAGIGGMMQDIAFAIPGIDEAMSFAEVLKQVKSLSYETIVFDTAPTGHTLRFLQFPTVLEKALTKVSQLSSQFGPMLNGILGANGTLPNGANLGEMMEKLEGLRDTIGEVNTQFKDENLTTFVCVCIPEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPKAESQCEQCNARRKMQKKYLDQIEELYDDFNVVRMPLLVEEVRGKEKLEKFSEMLIHPYMSPAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M3</accession>
    <name>A0A0B1P6M3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative histone h4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000942">
        <property type="protein sequence ID" value="KHJ34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6M3"/>
    <dbReference type="HOGENOM" id="CLU_109117_0_1_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19161" checksum="E9C8623292E8A744" modified="2015-03-04" version="1">MAKSRPSMAQKTIPKKVANDTRTSLRNAGKVIPNEKTRATTATKTGAGVSASGGRGKSINQTIKGIGVTRNFIGTKRMRKLTKDNIRAVTKGDIRRLARRGGVKRISGSIYDEIRKSMKSYLENVLKETCDVVEFAQRKTVSVTDVIFVLRRIGRPVYGFDHLGHLKNIRGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P6</accession>
    <name>A0A0B1P6P6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative contractile ring protein imp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002182">
        <property type="protein sequence ID" value="KHJ32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6P6"/>
    <dbReference type="HOGENOM" id="CLU_003525_0_0_1"/>
    <dbReference type="OMA" id="ETTVRWN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="960"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="909"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114243" checksum="4FE0EE145683AC4F" modified="2015-03-04" version="1">MPGTISNAPTVALSFANNFWGKDDAGVEPLLLRMHNAKQTCDELKSFYSSRAAIEDEYARKLLSLSRKSLGSQESGTLRVSLDVVKGEVEQMGKSHQNIASQIKTELEEPLAAFSGAMKERRKIVQSGIEKLHKVKLQQTNQVNKTRDRYEQECLKIKGYLAQGHMVMGQEERKNKAKLEKTQIHLAASNTEYENAIKALEDTTGRWNRDWKAAADKFQDLEEERLDFTKSSLWSFANIASTVCVSDDASCEKIRLSLEKCEVEKDIAAFIKECGTGQEIPDPPKYINFCRGDASDSQSELSEEDQYSVAQFQRTINPAYRSSSPQPSTYESHHGSAQINLTPDANDEVTSPFAKENDNSQKIRNNQYKKSHIDNQLNPRKSLIDAQSRLPMDRQNFEQNLQNARGLQVGRQRMEPDAQSDRHQPRERQPLEHGTSFYMQSQSEQPIHNSSQHSTQENQNLLNSPMYRKPQNSLQESNGSQISYDPFPMDGMTMLCRTGPSLEKSQGNSSGPSLERSPAHSSGPPSEKSPARSSGASSFCRDIQSDLTSLSSHEAISSKTTPIKQSSPSSESPVFKKKGGFFQNHGPFRRKSNKGYNNSRTMTPSNRNTWSSRSRANTNDTSLKDQIFSQSTKSQENNRLSRSPDTINPIANLQLNVGNNIFDVETPKQSSRAIQSPEVRKDEELDPIVQALAELKGVTKASSTRVSADKYHGITTPAPRATPLRNAASQQSNGAITAAQRGTPPPSYDLPVQRLGPPQPAFTSKAMQYTKQKYTTQTQNMFKAQGSPEPRAVREPSTNYRSNTRGREIPRALSPTVPREPSPRQEIKPETRHSYRSVSPNSYSEPQQNHQYTRQKTRSSDQVSYMQNSPSRMRVASPAVFRESDRPSSRNFGNEQQMQLALADDEYYAPYGGGRNSRGSGSMSPRPLSRYEGGGVQDLTNRQRSRSVADVRQYNSQGRPILHFARALYMYQAAIPEELSFAKGDVLAVLRHQDDGWWEAEIAGRNERPGLVPSNYVQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6R6</accession>
    <name>A0A0B1P6R6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative ubiquitin-protein ligase molybdopterin-converting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002161">
        <property type="protein sequence ID" value="KHJ32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6R6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6R6"/>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="OMA" id="GSWVVTM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="117"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="520" mass="57968" checksum="7845BA5E49B20AC4" modified="2015-03-04" version="1">MSSWWVQNSHVRLAATAIISGSIVAIAIFGLQEFQKKKRLNNLKKDIPAWDLIDKKVCLSNQTHANKISLTKEVKSSVISATEPRSGSKEDERCALLVEKVQRGEYDEELILEQLARNRVFLTDDGLKKLRSAFIIIVGCGGVGSHCATALARSGVARIRLIDFDQVTLSSLNRHAVATLADVGIPKVTCLMKRLHQIAPWINFDLRNELYRSEVSSNLLEDWNGKKPDFIVDAIDNIDCKVSLLKYCYENQLKVISSMGAGAKSDPTRIFVGDISTSTDDPLSRATRRRLRAAGVATGITVVFSSEKPSPEKARLLPLPEEEFIKGSIGELGVLPDFRVRIMPVLGTLPAVFGYTVANHIILQITGYPTDYITTKTRNKMYESIHAQLQGAEEKLTRILVLSEDVHGLRISITVADIGYLVDEVFKGRSALSKLTTRLALVRWRKPIDGGSKIVNRTVPGQIFSTLSLTDLVCMTKEEAAVHTRDILIGNKTLEDLYDHSTITYVEQMIEEELKYIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6S5</accession>
    <name>A0A0B1P6S5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative gpr1 fun34-class plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001928">
        <property type="protein sequence ID" value="KHJ32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6S5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6S5"/>
    <dbReference type="HOGENOM" id="CLU_051062_4_0_1"/>
    <dbReference type="OMA" id="PPNKVKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34104" checksum="8E721A12088FB391" modified="2015-03-04" version="1">MVSSGLEKQEAVDSPQPNDDGEHAARRHAECDELHRQFQSAGIKLSRDLLEKIYLPHNSTPYRSIASNSPEVKDFRKGLGTPAPVALVGFLICLSPLACDLMGWRGAGGNGAAGMGSYFFFGGLLMILGGLLEFIVGKTFSFVVFCSFGGFWLTIGTTLQPFYNVGAAYATAPNTTSLEQGFATVGFTASYGFFQVFMALLCFIYFICSFRTNIVNVFLFFFLTIAFCLLAAVNWVFAEIFAGDVTQIHKVHRIQVAAGAFLFMTCIVGWYSFFAIMLKLMDFPFQIPIGELSGLVESRTERMKKKSNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P725</accession>
    <name>A0A0B1P725_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000842">
        <property type="protein sequence ID" value="KHJ34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P725"/>
    <dbReference type="STRING" id="52586.A0A0B1P725"/>
    <dbReference type="HOGENOM" id="CLU_045011_1_1_1"/>
    <dbReference type="OMA" id="TAPNGFW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="301" mass="34247" checksum="7D8F94CC276CC475" modified="2015-03-04" version="1">MGSKKSEEEKIVLRILHQSQLIMTDSTRRPKVIIFDIGGVCVNSPFQAIREYEIENNIPLGWINYGIDQCKPDGIWHRLERGEVELDDSWFSVWGKQISNPILWNLFWQKRFSTPTPPMPRLDLQKLFWSIIASTQIIDPWMFPALQTLKKSQQFILMALSNGFKLPPPHDKIYEEKVSSLRSIFDIYICSAEIGIRKPDPKIYEYALEAANNFAKKNIDSPKAISLGWEKGLFPRDVLFLDDIGENVKGGKLAGFSVIKVELGKTWEAVEALEIATGMKLSGDHPKSTPISRAKVNSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P726</accession>
    <name>A0A0B1P726_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2837</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01002060">
        <property type="protein sequence ID" value="KHJ32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P726"/>
    <dbReference type="STRING" id="52586.A0A0B1P726"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OMA" id="TQPFFSQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="45"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="57163" checksum="24F04AC743B5A00A" modified="2015-03-04" version="1">MFVCRKVPAYFASARVRGTFSFQISKRAASSLTTCPQQKLLAASLENSDPTIYEILQNEKNRQKHFINLIPSENFTSQAVLDALGSVMQNKYSEGYPGARYYGGNEYIDQAESLCQTRALQTFGLNDKEWGVNVQSLSGSPANLYTFSALINVGGKIMGLDLPHGGHLSHGYQTPTKKISFISKYFDTLPYHLDLSTGLIDYEKLEEVALKFQPQIIIAGTSAYSRLIDYQKMKATAEKVGAYLLADMAHISGLVAAKVIPSPFEFADVVTTTTHKSLRGPRGAMIFFRKGLRKVNQSTQEKEIWNLEEPINFSVFPGHQGGPHNHTITALAVALKQAQSPEFRAYQEAVLKNAKAFSQHFSKPKERGGLGYTIVSGGTDNHLVLVDLRPQKIDGARVERILELVGVACNKNTVPGDRSALKPSGLRMGTPAMTTRGFGQEDFIRVADIVNRAVIIAQRLEKDAEEAALANGKKNPQSLKAFIEYVGGGENEREVVQLRSEVENWVRTFPLPWETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7G0</accession>
    <name>A0A0B1P7G0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cation diffusion facilitator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001780">
        <property type="protein sequence ID" value="KHJ32851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7G0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7G0"/>
    <dbReference type="HOGENOM" id="CLU_013430_2_2_1"/>
    <dbReference type="OMA" id="CWALRNQ"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="44652" checksum="845E66948DCDAFD4" modified="2015-03-04" version="1">MSIDIEKNRHVTNTCQSDPYQLRKRYKSERYLNDICSRETWRLLHNFPLSRNFNTRRRKQVRNFYTKQNERIEWMLKSVNDSSIEARVEGVAEQRKVQIAIYASLFASILLAALQIFAAITSNSLCLFTSMASAIFDPLSNLALIICNLATKKVNLKRFPAGKSRLETLGNISFCFIMISVSLFLIILAIRELMNETTNGDMEFKLPSLIAVIAALIIKLHLLFYCWGLKDKYSQVNILWQDHRSDLFINGFAILMNLLGSKFMWWIDPTGTIIISIIVSFIWLRTMFGEFLLLIGISASFDIHQLVTYICVIHSPSIKGIETVRVYHSGPKLIAEIDILMGPDRSLRQTHDVAEGLKTKLEKLPDIERAYVHVNYEIAHKLEHSNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7G2</accession>
    <name>A0A0B1P7G2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative meiotic recombination protein dmc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000779">
        <property type="protein sequence ID" value="KHJ34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7G2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7G2"/>
    <dbReference type="HOGENOM" id="CLU_062681_0_0_1"/>
    <dbReference type="OMA" id="WIVAFPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="24937" checksum="A66D75BF433DC484" modified="2015-03-04" version="1">MTTTSSNSSTLPRPRSKPLRAGSKKEDAIRRYAEEKILHISRRFTKKFQPAEESRFGDVKGYVSFEEVAVDLGGLADVVWLSATPNLQTQYLLSIAGILITYLPAFPPVPSATLSILKKMDHAFSSLLKAEDIVTGEALPGFSGSMNVGFSKTDMVRLKGLVEETRVLVVNLMGYMELEEDKTDPQTETSMDSFENCDMDVARVYEHTIVQLEKLLELSNLQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7N6</accession>
    <name>A0A0B1P7N6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycylpeptide n-tetradecanoyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001502">
        <property type="protein sequence ID" value="KHJ33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7N6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7N6"/>
    <dbReference type="HOGENOM" id="CLU_020336_20_1_1"/>
    <dbReference type="OMA" id="MLTFRHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="40720" checksum="8278C4BCF03F2CBC" modified="2015-03-04" version="1">MMVTAIEFKNSKKSSSQRPSVEEILANPSFADTVWNLKPSLYGKLPVAIGRGGPFIIDWEVHGTGEIKLVFVMGLGSIKTSWQRQTLKYGHEQGDKYSVLIFDNRGIGKSDKPILRYSTSEMALDVIEILDALKWTKQRQVHIIGISMGGMIGQEIAYLIPQRICSLNLMATAAKIENTTTFFENMQTRIRMLVPKTLENSITDSSKTLFSDEWLNEPDCTEVPSPGTPNVEFPPSGKYGKFSTNYERYAAHELCKRLDPEAFGRKGFLLQLIAAGWHYKSPEQLKEIGDKVGRDRIMVLHGTADRMITVPHGEKLIEWLQPGTAIIKEGTGHGFILEEWRYHNQLIESMVEKCEALNLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7U5</accession>
    <name>A0A0B1P7U5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative 3-oxo-5-alpha-steroid 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000958">
        <property type="protein sequence ID" value="KHJ34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7U5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7U5"/>
    <dbReference type="HOGENOM" id="CLU_059260_0_1_1"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="160"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="35500" checksum="E50022E89EDA7C5A" modified="2015-03-04" version="1">MTAPVTLKVTNKSPRQPVKKLPATIQVTETTTVQDVKDQLSRLTDGRSPHRFGLFDPEKKKTLKDRKALILQIKEVASAQEILVKDLGPQLSWKTVFIIEYLGPLLIHLLFPFVLRPYVYGNNQIPPLSYSQYLSSAMIVLHFLKRELETLFVHKFSLSTMPIMNIFKNSAHYWIGSGIFIAYFIYHPNSYTQRESPLIDNINLIGLVTYIFGELSNAHTHITLSRLRSKGGTERGVPRGYGFNLVTCPNYLFEVIAWIGINIVNKSLATAIFTAIAWAQMHVWALKKEKALRAEFPDTYKKKKHVIVPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P819</accession>
    <name>A0A0B1P819_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P819"/>
    <dbReference type="STRING" id="52586.A0A0B1P819"/>
    <dbReference type="HOGENOM" id="CLU_522953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="57148" checksum="0B7306D3CF74098B" modified="2015-03-04" version="1">MSRYLQNKAATRGAGQVKDLSKSTQQPNRSLPALSTRPNTEDTSPLTAYQSTEIDNARFEEVVGKMSVPQELQEMIEAEICRAAEAKANIQIFTTAINAVEDSLSPMLTGGNKSFLDSPGLSPGFNSAIPSTSTLSQKQKTSALNNGVKKSIPKDDRLFDRIFLRIPRNHEWRSFTPAGIREAVIRKLDCSPTTIDRIIPVTSGYAIVAKDETGRQLLLSLSHRLPEDILLEAARDWVSYMLPNIPTHIVTIEGRKPVAESEVIAELERVTGLTPKSVRYRGKSKVGAPYRTWMVFFDKDSAPKPGFRLFDDSGRATPLKPVCKRRFYSTGCCSRAPACGRCGSIMHPEEECKALTKCRNCGGPHRSDSRKCLARPTKAGKPTKEQLQVIRIAGQREFDAVNRARAAVDRAKAACISVSSTPASNPEAQAGIIPASVELTIATPQQCRGGITNDIALSRAYEIGIDVALIQEPCSSSRTKSHPEFDCHMPYGGPDVRPRAVIYTRKNEKEINAVQIFSCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P890</accession>
    <name>A0A0B1P890_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001780">
        <property type="protein sequence ID" value="KHJ32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P890"/>
    <dbReference type="STRING" id="52586.A0A0B1P890"/>
    <dbReference type="HOGENOM" id="CLU_041826_0_0_1"/>
    <dbReference type="OMA" id="PTRYFSM"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="331" mass="37756" checksum="4472D3603C074BEA" modified="2015-03-04" version="1">MAPQLLPASAAAFAPRATHVNVVLGPKVETWLTHILKRIIRSRRPLNSVVKLQRCLTELLSSKTAVWNLTSLMVLRVPDNKLYRDPNPLIEALLNYRIIHLEAYIVHVDMVLENEVAFKLTSQSIEALIEYHREVYSVNISSSISSWPEMSTQIEELHKDFIHSINKFVYRTHVSVLEGLYEDGAGELLSEESEEIKMHILNLFRSVKQPPWIKEKINTEVINSNCGSQQNTVPYVSEMREKETQILLSPITISSNNSIAACCHMELQNSEQRSLISSLNQPQLFNEILFSSSQSTYLAPNLYTQLGIVEQSYLFNPGYNIQACDPNFNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D7</accession>
    <name>A0A0B1P8D7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001728">
        <property type="protein sequence ID" value="KHJ32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D7"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_1"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="844" mass="93269" checksum="62F1A9FB79FF8CEA" modified="2015-03-04" version="1">MVNFTVEEVRALMDKATNVRNMSVIAHVDHGKSTLTDSLLSKAGIISAAKAGDARATDTRADEQERGITIKSTAISLYGNLPDDQDLADIVGQKTDGRDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQVTKEDLYQSFSRTIESVNVVISTYLDQSIGDVQVYPQKGTVAFGSGLHGWAFTLRQFSIRYAKKFGVDKNKMMERLWGDNFFNPHTKKWTKSDTYEGKPLERAFNQFILDPIFKIFAAVMNFKKEEISTLLGKLQIKLPADDRSKEGKALLKVIMRTFLPAADALMEMMILHLPSPVTAQKYRAESLYEGPADDEACIAIRDCDPKGPLMLYVSKMVPTSDKGRFYAFGRVFSGTVRSGLKVRIQGPNYTPGKKDDLFIKAVQRTVLMMGGKVDPIDDVPAGNILGLVGIDQFLLKSGTLTTSETAHNLKVMKFSVSPVVQRSVEVKNAQDLPKLVEGLKRLSKSDPCVLTSINESGEHIVAGAGELHLEICLKDLEEDHAGVPLKISDPVVSYRETVSSKSSMTALSKSPNKHNRLYVVAEPLGEEVSGAIESGRINPRDDFKARARILADDHGWDVTDARKIWCFGPDTNGANLLVDQTKAVQYLNEIKDSVVSGFQWASREGPIAEEPMRSCRFNIMDVTLHADAIHRGGGQIIPTARRVLYASALLAEPRFLEPIFLVEIQVPEHAMGGVYGVITRRRGNIFAEEQRPGTPLFTIKAYLPVMESFGFNGDLRGATAGQAFPQSVFDHWDILPGGSPLDTTSKINEMVRKMRKRKGLKEDIPGYENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R1</accession>
    <name>A0A0B1P8R1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000531">
        <property type="protein sequence ID" value="KHJ35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="821" mass="92768" checksum="A2337A812D13C0E3" modified="2015-03-04" version="1">MDIYLKYARIQHVGLSQFTEAQNTITKARNKIENGQELKNSYWTVRKKDREDWRKIWFGKDSQRKQKLAMKMAAYKCWQESWQRVKRCHGAGGRRVADPENWKAARILQNQKTGEDILSFSKAPVTLHKRLSRAQSSLAIQLRSEHIGLNAYLYRRKVPGVKSPKCRCGYPSENVKHVVMACPLKSEGRAEVWRKAKNRSFEAMISDPEDLKRITQWILDKKWFEQFRLVGEVEKLTQNRNKRRGKRGTVMEVDDEFPALATIARPTPPSPAAHPSPSPIPSITTPVQTTVNKDDNCSQPHRPILNPVAPSKRAAQNSTDSMTQSASNETYQIPAYLPKELRDIIQKRQEQERAWHFRLSICAGVICNIESTLENYKGDIEKREADLIRGYLQQAIARLAASNNVPKPPQIPLKTKPLRSTTHKERQDIERKKLSSGTSKSPTSQSILKPQKVVFEDYNKSAIEKSSWVTVARNGHKKSRIIASTPSVPSAKILDIQKNMLQASNLNQSHKKKVIVPISDSRLFVRLPINHEWRTLSPSGLREVIVKHLGVSPASIGLIKPVRTGFALSPCSSEAREALLQTSSWLLNTGAKIEPASNWIPLLVPTCADHPRRAVTISTLEGQIEVNKEMLANEIERVTSIRPASVRLYVSSNQAAPHRTWMAFFTKAPRSGFRMFDESGKVTFFKKQKTIDFCKRCNGHHPSRNCSRAPFCGNCGSVMHTENDCKALTKCKNCGGPHRSDSHKCLARPTRSGGPTKEQLKTFRTVVEREYQAVARAKATEKRALASEDNILISSSQSPEHSNPTNQQSPVEFSIGEQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T9</accession>
    <name>A0A0B1P8T9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001627">
        <property type="protein sequence ID" value="KHJ33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T9"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="13882" checksum="8040F039A361EBAE" modified="2015-03-04" version="1">MHTQDVCMAATRCRNFGGPHRSDSRKCLARPTRHGAPTKEQLKVYRQADNREFQPAVRVRATEEKASEMEALIGNTGNGNPVLEANKTTIMSVPKSPEAEEEIIHTFDNVTQESVEVVADSSMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P978</accession>
    <name>A0A0B1P978_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P978"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="23059" checksum="11901E5BF72CCD1C" modified="2015-03-04" version="1">MDITQELQALSMEMSIEPHPIPNPLPSTTPPTPPSNSQTLSYSTASRNILKPTVLIQRPLPERPLLNNKNSPNAANAFLPREFAEVVAIRQRRERTWYERLMICITIHSCIESTLSNFSIEIEKEEAETFKAYIQLAIAKFAAVDSFPSPQIPTHTRPTKGDGIGKDVGTGKKVAIVLPQKPVGVVLNRGEVEETPSLPFIHKITENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9P2</accession>
    <name>A0A0B1P9P2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001072">
        <property type="protein sequence ID" value="KHJ34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9P2"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="116" mass="13073" checksum="F67162196013CF27" modified="2015-03-04" version="1">MLLPQELADIIATRQRRERAWHSCIMICKTINSSLESTLAKFRDEIEKEEVEAFKACLRLTIASFAAADNFLTRPKAPTHSRPTKYNCKGSRKDKNMLKEVAIATTQIMKGAASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9P3</accession>
    <name>A0A0B1P9P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000417">
        <property type="protein sequence ID" value="KHJ35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9P3"/>
    <dbReference type="HOGENOM" id="CLU_115072_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="207" mass="23491" checksum="AD51AD32F80196A1" modified="2015-03-04" version="1">MKTENYVESESEEESISLEAFLTGPAQKRLRSEQGRIEVQDLPNSESSSRPRLQKTSVGKPEENGMKTVKALREIVGRKGLGPLNYRALAEKLNVPLNLIEFFQASPDAAKEFRKMSQRLNIRKGLRPGNKAKTKAKISADCASVKVDRRNTNSRETLTQSDFNIDTKTISPRVNPEHKVFDFVAVLRVRYNEKCRWKKVILFPGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9R9</accession>
    <name>A0A0B1P9R9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pre-mrna splicing factor clf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9R9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9R9"/>
    <dbReference type="HOGENOM" id="CLU_013054_0_0_1"/>
    <dbReference type="OMA" id="KNTEWNE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="526" mass="58115" checksum="1F6B291ACF9AB225" modified="2015-03-04" version="1">MSLRSQSSSLDDSCTVVYNHTIYSYSSESFQSLKLEKNTEWNELPMGVPVKGGVCVHRTPENNDSPASMFIVGGVTDMDTYHGLQRFTFESQTWDTILLSDQVIQNRIYHGAVYLNASDSILVYSGIQDKQEGLSSQTFTIQASEPYRVTAYQSIAPPAKSPVMLPWSSNQAVYLGGSENNRKVMLFDPKTSWVDSGITLLNPVVNTENVKSTIISGDDLTKVLYTFDLSKSPNSVNMTVLRNADGSPIQNARQSFSQGTQNSPKSNKNLTAKNWPSYDATLAPRISRKVCTISYDLSSGLVVFAGGSEVDSISIFDARGNHWDNPLDLLGSKELNPPGNSASIAISDNLKGSQQVSETNSPLPAKYLAAIIVSILISAVLIISLLCFTRSQKAKAQNNKNNDPRFKGGPDEEDGMDFIDKGVSDEILEKYSSSSSGRSNQSKKDSDYNNSHHIYKDVISKPISLHKRQGEDSPTYLEGARPAPLPNENWNSERRSSGWNRYWSSENSSQVDEYYVSKSNNPYHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA26</accession>
    <name>A0A0B1PA26_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000352">
        <property type="protein sequence ID" value="KHJ35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA26"/>
    <dbReference type="STRING" id="52586.A0A0B1PA26"/>
    <dbReference type="HOGENOM" id="CLU_023864_0_0_1"/>
    <dbReference type="OMA" id="FQFSHTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="639" mass="71098" checksum="39BB0F14071F6893" modified="2015-03-04" version="1">MDYFAPPFPYQQQFRRVIPLIPDRSQLCSIANHLPPYAVAQATTIVEAKPRLGKDEVNKLEREFKKNPKPSTQTKKALAEEMNVDLPRINNWFQNRRAKRKQQIKAKGEEAIQAPEALNYPTPTSPETLSHGNDLYSDDHQAISEPVVSTYKMSTDFTYSPEMMEFSSVAMESYGQTSLPFRNTCLMNHEALYLPNNTICSSNLPLDSGNSSTTGLSEYFSYEPPHKIDTKDLKPIITSPSQAVSLTNKNMHLLNTMTSTSLMRSDTTLSASSNCCSSQSNEDYRKNTQGDNAISSNVIHDINPQVGKFEAPLYDPEFNQETLGPQPAPSNKTFVSRPPVNIALRRKKVQQRPAALTAHTLSNRQLAGPCTTSHVDGSHFSAKSPCELSMRRIVSAGGNRAVVSGRVQKHSFDVSQRSPINIGGFENVGTIMDYNFHNIYNPPPLTGISSICGSLAPPTPIDFNFGSQDSNGPINSPGDGSHNFLFNYNTTNCLISIDKSNQDLTMVENLQSLPLDQISSNHWPTPIDYHDKNSYCKINEEPSYTTINNQFSSRLQLNEQLPSDIKNQYATQGFIPSYSYDCTVGHTTMPCGTRSSLSKPEVEYSFNGSFSQEKPSNEVTGDRKICQFSHKIQSDFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA91</accession>
    <name>A0A0B1PA91_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001348">
        <property type="protein sequence ID" value="KHJ33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA91"/>
    <dbReference type="STRING" id="52586.A0A0B1PA91"/>
    <dbReference type="HOGENOM" id="CLU_053544_1_0_1"/>
    <dbReference type="OMA" id="TGLFKFE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34913" checksum="E7A56D99274F29A5" modified="2015-03-04" version="1">MSTTSPSISRSYVYLHFPKSAKASLVLTSFHPWKLRQFYKSRISTRKYEKRFLATVNQEINYPLDFRASGPFKSTESGKNGPKYDERTVKLGKTLRTLQERLPTLLQKPLPSKLLSPRITLNLFPSTHPHLPSVTGRVAYSAALWTSPIAWGRLPLISNVRLEILSERMIKHSHLSCPSRSYRPEQLVVRWRTTSNSHEQNSTAFIYNSSLNDNVDKITEWLGGGNKNDDIGKDFTGLFIFEFDEEGRILTHTIEHAQEGGNWERGVGAKVVGLTDWLLGGMKGSGRGESAPCPAFCGDNSKQRYGPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAD9</accession>
    <name>A0A0B1PAD9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000311">
        <property type="protein sequence ID" value="KHJ35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAD9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAD9"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OMA" id="YHECSAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003285">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="154" mass="17446" checksum="D1EA18A5D078B320" modified="2015-03-04" version="1">MGREGLKIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQTDLRDDPSVREKLSKQKMQPVKREDGERMAKDLGAVKYVECSALTQYKLKDVFDEAIVAALEPPAPKRKHRPCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAE0</accession>
    <name>A0A0B1PAE0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAE0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAE0"/>
    <dbReference type="HOGENOM" id="CLU_2348241_0_0_1"/>
    <dbReference type="OMA" id="NIRMDDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="10894" checksum="AE9C0E3D6CCB5E76" modified="2015-03-04" version="1">MVNFYAGGLSAQIFWCFSYPSDVVKQRIMTDPLGGTLRDGKPRWLGWGSGWWNAARGVLAESGYKGYWRGFLPCFLRAFPANAMAMATFEAVMRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAE8</accession>
    <name>A0A0B1PAE8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5122</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01000304">
        <property type="protein sequence ID" value="KHJ35672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAE8"/>
    <dbReference type="STRING" id="52586.A0A0B1PAE8"/>
    <dbReference type="HOGENOM" id="CLU_001871_0_0_1"/>
    <dbReference type="OMA" id="SWKVHKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="747"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115762" checksum="27D66EE1CE074828" modified="2015-03-04" version="1">MELANGNEKARELRMDSVENSSLTLLPPSVANVVSLVTRSSSLYLRAGTFIGRLALYGAHHSTLTGLELSRAIMENILIQAAKNLTDRSTRGFGDAEADGILEKSLNKLHSTITNISFAVSTGFCFSYAAMDSVCYMSRLLLSSLDSIFGSTDSSKAIASIIALIRREFQNPATGREGEKVGVADLIVGACGLALLQQWCRKITETEQNNCEIVWDVVVLKNGKRADVVSNNGLALVKADSMFLVPTTRGHEIMTSIEQEDVKIGNEVDELPEITLKERISKALPPNASVSVHTQTNVTKIITAIVTGAKPPKILLPPDIEMIDQETWHNKNIETGRDDPSVNKSVSQLTPIYRVTYRAYRGSLNKTDSNRNHGNRISSGSLKNDDSVDFSLGLALPCKFRPNSERCFDKSRPTSPENVNREQFACHNSTDNLANQKRSRKPAITSAITSSEQASRKFMAKSPISTAKHENISLLKAPDKNIESSCISKHIRGFASLDSLSLSTLNDLTLISSNDLPKTNRPRSSHYVCPQDLGFSDFPKSISGPSYFYMNSSNNNAITSKSEKSNFPSDYIDHWTAKRLFRARSEKQIASTPMSAPPVTHRRSKSYVSNILNVQKHILENSIYLRQPRSIFSDLDRLSRTGFVADLFPKYHLVRNITRYVRFASASYGSHFLRLMGISTGDSGRDIDETHHYEHHSFSTHTQLPPSTILLSSFVDSQGGTDSTGQTNTGVPMVHFVSLDHDSKAVVLACRGTLGFEDVLTDMTCDYDDIVYCGKAYKVHKGIHASARRLLDGGGGRVMATISAALVEFPGYGFVLCGHSLGGAVSALLAVMISEPNETSTAFFTKSLLPQLANGPSKLQPQLPKGRRVHVYTYGPPATMSPSLRIATRGLVTTIVNGQDLVPYLSLGVLHDLQAVALAFKTDDKGAKIEVTKRVLQALTGKFSDTWNNRQRIVNEDNDQWAYSTLKTLRACMLSTKLVPPGEIFEIETMPVLQRDGLLKGPLGRPATRVIVKYVKDVEKRFGEMQFGGSMLLDHSPGRYEASLNALGNGVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS3</accession>
    <name>A0A0B1PAS3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAS3"/>
    <dbReference type="HOGENOM" id="CLU_061887_0_1_1"/>
    <dbReference type="OMA" id="KWKVRER"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="27147" checksum="40A089968982DAA6" modified="2015-03-04" version="1">MSSMRNAVQRRSYRERDQPKERKKWGLLEKHKDYSARARDYNEKKAKLKALRQKVLEKNPDEFYFGMMSRIGPKTGKDSSGTIAGDRGNQILSQEAVRLLKTQDLAYIRNARNIVIKEVANLETAVKGIEGQGRKVIYLEDGSDQLTEIFNNGQIHQTNEDNNESLELLDTKNRRRLQQCQAEKLRAKLVVARERLKALADAEQALDLQRAKMAKSPTVGGINKHGIKFKVRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAU7</accession>
    <name>A0A0B1PAU7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001239">
        <property type="protein sequence ID" value="KHJ33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAU7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAU7"/>
    <dbReference type="HOGENOM" id="CLU_012062_12_0_1"/>
    <dbReference type="OMA" id="ENFKRTH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="211" mass="23384" checksum="91ADFA44242A5D84" modified="2015-03-04" version="1">MIPRQFSFMLPSKIKFSFPVRNFHCSTTNMSVKTFFKVNWEGPVLDQAGRPTAKIEKQSGTIKFNLFQQDVPLTVENFRALCTGEKGFGYKGSAFHRIIPQFMLQGGDFTRGNGTGGKSIYGEKFKDENFKLKHNKPGLLSMANSGVNTNGSQFFITTVVTSWLDGKHVVFGEVADEESMRVVKALEATGSSNGNISYTNKPVITDCGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY6</accession>
    <name>A0A0B1PAY6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 50s ribosomal protein mrp49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000235">
        <property type="protein sequence ID" value="KHJ35837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY6"/>
    <dbReference type="HOGENOM" id="CLU_1948476_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="130" mass="14650" checksum="4F37D5CCCD2CC9C3" modified="2015-03-04" version="1">MIVERLEDPSCPATLTIHFKSRNVTITTQLDENSSISGAKGSPTKDDAMLPKITRKEIRMKGQTHTKILDNFLEATKAKPVICSEKDNQEIQWLERVSSNSLREANIMKIHNEKKKKQEEMLSAAKGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB25</accession>
    <name>A0A0B1PB25_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cyclohexanone 12-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB25"/>
    <dbReference type="STRING" id="52586.A0A0B1PB25"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OMA" id="ASWTLKC"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="55776" checksum="1CA4CA4DCD189667" modified="2015-03-04" version="1">MGSIDRPSRLFDILIVGAGISGIDMAYRIKTEFPKYNYAILEARDAIGGTWDLFRYPGIRSDSDLHTFGFPWRPWLEDKSIADGESIRNYLNECAEIEGITSNIRYRHKVLAGNWSSIDQKWTLTVDINGQKAQYNARFVVMCTGYYNYKEPLKAVIPGLSDFKGLVIHPQFWPEDLDYTDKKIVIIGSGATAVTLFPVLAKKAAHVTLLQRSPSYILATPGVDKSAKFLRRYLPVIVVARLMRIKFLVLSFIFYWFCQFFPRTARALLRVNSRSYLPKDYSTEVHFNPKYNPWDQRLCVCPDGDFYRALHQSNADIVTDTIETVKNDSIITTSGKLLKPDIIITATGLNLQLAGGATITVENEPFNAASKFFWKGVMLQDLPNAAFLIGYTNASWTLGADSTALLICRLLRHMEKNKLSSAVPYLSSSEISNVQIKPLFNLKSSYIEAAKDVLPKSAGRHPWHGKRNYFLDSWDAEFSDLQKGLTFVKSKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB37</accession>
    <name>A0A0B1PB37_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="JNVN01001190">
        <property type="protein sequence ID" value="KHJ33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB37"/>
    <dbReference type="STRING" id="52586.A0A0B1PB37"/>
    <dbReference type="HOGENOM" id="CLU_045832_0_0_1"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="28"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="348" mass="38075" checksum="A365CA70C63F6120" modified="2015-03-04" version="1">MASTKEFTLICLENPLLDIQVFGDDSLLQKYGIKPNDAILAETDLHKSIYDDLLNNFPAKLIAGGGAQNTARGAQYLLPPDSVVFIGGIGDDKYADILKEAVKKAGLRVEYRVDAKEPTGRCGVIITGHNRSMITDLGAANHYNLQHLKSPEVWKLIENAEFYFIGGYHLTVCPPAIQALAEEAAAKNKTFIFSLSAPFIPKFFKEPLDDTAPYWDYVIGNETEALAYAESHNIESKDIKEIAKALAALPKKNNEKKRTAIITQGTEPTIVVIDGQEPQEFPVHAIDKDLINDTTGAGDAFAAGFIAGLVSGFSLPQAIDQGQWLAKLSIQELGPSYPYPKQHYNPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB88</accession>
    <name>A0A0B1PB88_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative formamidopyrimidine-dna glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000991">
        <property type="protein sequence ID" value="KHJ34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB88"/>
    <dbReference type="STRING" id="52586.A0A0B1PB88"/>
    <dbReference type="HOGENOM" id="CLU_038423_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase H2TH DNA-binding" evidence="1">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="29336" checksum="525E6A7164D62963" modified="2015-03-04" version="1">MEATNPDARNEMGIENGTSMAEVAFTDPRRFGRVRLLNCDKEDIRKISPLKENGPDPIIDKSILSLEWLQSKLNCKHVHIKSFLLDQANISGIGNWVGDEILYNAKIHPEQYSDTLSVEQIKVLHHCIMYVCETAVGVLADSEKFPSDWLFNYRWGKAMLTKTAKKRKNSEDSKEPTHEDPKCLPNGTKISFVTVGGRTSCFVPSLQQKKLQDKLSNDYDEENENLSENRLRKRVKKDEETLEIDKNKRTLRSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBQ7</accession>
    <name>A0A0B1PBQ7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="JNVN01000709">
        <property type="protein sequence ID" value="KHJ34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBQ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBQ7"/>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="14">
        <location>
            <begin position="92"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="15">
        <location>
            <begin position="500"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="658" mass="73542" checksum="D68F09A809CA757E" modified="2015-03-04" version="1">MAFRQRLSRSLLYPSLATLSVGGIYYNFRSRHTLDPAGPANSITNDGENRVPKLPDIKSRDEQLADLKYSGISSEESNLVSKRPQKNDNVYDILVIGGGATGAGIALDAVTRGLKVALVERDDFSSGTSSKSTKLVHGGVRYLEKAVWDLDYSQYKLVREALKERSYFLQTAPHLSSWLPIMLPLNKWWKVPYYWIGTKCYDLLAGTEGIESSYFLTRSKALDAFPMLKKTDLVGALVYYDGAHNDSRMNVSLAMTAALYGCTVVNHVEVIGLEKDQNGNLCGARLKDLVPKKNGEKADKFVVRAKSIINATGPFTDAIRIMDDQNVKEIVAPSSGVHIVLPDYYSPRNMGLIDPKTSDGRVIFFLPWQGTTIAGTTDTPTSITNNPVAGQDEIDWILSEIRHYLSPDINVRHSDILAAWSGIRPLVKDPKAKNTESLVRNHLIDVSPSGLLTCAGGKWTTYRQMAEEAVDEAIIQFKLSPKPVIGYEMINDGFELDGTCQTHRVKLVGAHGFFKNLFINLIQMYGLETEVARHLAESYGDRAWTVASLSSLTKRRYPIRGERISPLFPFIDGEVRYAVRYEYAQTAVDVLARRTRLAFLNAQAALEATPKVIDIMASELNWNDHRKNKEWEDAVKFLESMGLPKSMLNLNRNQVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBX5</accession>
    <name>A0A0B1PBX5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g3098</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000677">
        <property type="protein sequence ID" value="KHJ34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBX5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBX5"/>
    <dbReference type="HOGENOM" id="CLU_055386_0_0_1"/>
    <dbReference type="OMA" id="RRMENDS"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="304" mass="33943" checksum="E3F589D04089577B" modified="2015-03-04" version="1">MVVDALRSDFVYGNRSGFNFTQSLIRSGTAVPFTAHASPPTITMPRIKTLSTGSIPSFIDVILNFAESDKTSSLASQDSWLTQMKAKNTGKSIMFGDDTWLKLFPQTFDRADGTTSFYVSDFTEVDTNVSRHIPQELENKDWNVMVLHYLGLDHIGHKSGPKSPNMFQKQREMDNVVNQVYMALTSKSHLESTLFLLLGDHGMNDAGNHGGSSPGETSPALVFISPKLKSHSRKLQAPLQYQEDFRYYTYVEQSDIVPTLSALLGFPIPKNNIGTFIPNFLSFWPAGKIKHILTRIRNVKACRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC42</accession>
    <name>A0A0B1PC42_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative zn 2cys6 transcription factor acum</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000828">
        <property type="protein sequence ID" value="KHJ34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC42"/>
    <dbReference type="STRING" id="52586.A0A0B1PC42"/>
    <dbReference type="HOGENOM" id="CLU_010748_0_0_1"/>
    <dbReference type="OMA" id="NQGLEAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="7">
        <location>
            <begin position="326"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="438" mass="50212" checksum="188CC288D2512FC5" modified="2015-03-04" version="1">MQLRERPCTRCIKRRIGHLCHDEPREFNLTTKKIKIPQNPSAIENNELCKKHSQKNTSNGMSTSFKTSQEHSQENLTIGSSAQPQASLQIIQLSPTTGVSTNTTNDGSNQFFENFNDWTQSQSNQFHEMHNYHPLYMFNAPEVTTECNLLNDFLNNSLRDDGTIFAGEISNNYSDQVNGALASDLRNHNGQNDPHALGPVASENLISRPSSAIQNDKAREYYLQAADPTGNDAPEERMQRLFQAKHDAGMLKPFNYVKGYARLSAYMENHLQPAQKLKILRQLEHFQPKFRENVQTLTYIELIYVEMWFERSLMVYDRVFASMAIPACCWRRTGEIFRGNKEMAELIHVPTENLKDGKIALHEIFAEESLVDYWEKFGAIAFDHSQKALLMSCLLKSPNEKLKGLTIKCCFSFNIKRDDHEIPSLIIGNFLPQDPYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC70</accession>
    <name>A0A0B1PC70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative small nuclear ribonucleoprotein sm d1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000604">
        <property type="protein sequence ID" value="KHJ34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC70"/>
    <dbReference type="STRING" id="52586.A0A0B1PC70"/>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="OMA" id="TFLMKLT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="113" mass="12242" checksum="4BE7DA26356B217A" modified="2015-03-04" version="1">MANLKIHGTIIHGTITSVSPQMNTALRTVKMTQRGRDTINLDTINLRGSTIRYYILPDSLPLDTLLIDDTPKPKNKARKEATDRGTGRGGRGRGGPRGRGGFRGGRGRGGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE3</accession>
    <name>A0A0B1PCE3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative molybdopterin binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000782">
        <property type="protein sequence ID" value="KHJ34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE3"/>
    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
    <dbReference type="OMA" id="EGWAPGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="28695" checksum="CBE0C9750EC9DBDE" modified="2015-03-04" version="1">MAKFCFRLGIVLKKIEVIPDHEKEIAEAVRRMSYMYDFVVTSGGIGPTHDDITYQSIASAFSLPLVLHNETVNRMRRLSKPHPSQASFSWDTPSPALTAKLRMATLPIDSSKPIEHQVIYPCDDLWVPVCCINENVHILPGIPRLFERLLDGLQPHMMPHLGDLEARQVVRIMVSTPLVESEIAGYLTELAKRVEGRGIKVGSYPRWGKSRNTVTLVGTDRNYMETLVKEVEQNISGNRVTVEGEDDSDREGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCI6</accession>
    <name>A0A0B1PCI6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000040">
        <property type="protein sequence ID" value="KHJ36392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCI6"/>
    <dbReference type="HOGENOM" id="CLU_794991_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="349" mass="40435" checksum="42446A0344E3EFBA" modified="2015-03-04" version="1">MNSNNPEIFPRFSELAPELRFKIYEYMMPRPHVIPLDVMYTSDGNFRISYDDGNGTEEDEGIEDDDVKVKADYLPLITKHFVRSMSHTCRELRKLYNSTYPDRLELSHGNGVINLHYSKSIIYLRRFDRLVSQPVISHFLFDRISGSNSNSNSSSDNSNNIKLWHHSYSLELPKCFNYITQLALPIDCIVEYPELSPHPFTLQSQLNESALFAKMLQPFPNLKHLWAIPDDVYWQLDIQLTLRGFLQPYPGYTNVSVLGCLAERKEQLFLWAEYRNAMIHRRQLMRYTNLPKDVAANHTTSLASLASISSSSSSEIKPAPESMYTPPILMIWGLEHVDLWDFLCEVDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCR3</accession>
    <name>A0A0B1PCR3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCR3"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="30713" checksum="2B886CF0EA94BF99" modified="2015-03-04" version="1">MAPPLASKRALPSEPPDARNRVSKPKPKSGRISRAAAAKTHLLLATGDAFEKGVTNPRVSHNSSVDSQQGVASLMEAIKGLLDLTNDYLKNLEIQHPGIGADFLALLADGASRAMRGERVYCSVPKPVPTYNQSSKDTWAEKAKFQSSGSKILNVQRLTINASPPQGQSKEDRCTIQKLVPDSSLVTDAWIVPSGIAVLAPTPAKAAAILQAKKAIEDRFGNAFVERQEVWITFVIGPIHKRIKGLDILCDPMDGLLQEELAHINDVVPMREMGWTRRSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCT6</accession>
    <name>A0A0B1PCT6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative pre-mrna-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000498">
        <property type="protein sequence ID" value="KHJ35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCT6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCT6"/>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="925" mass="104196" checksum="85CCB1C04E6C85E1" modified="2015-03-04" version="1">MSGRRDFLNQPAPENYVAGLGRGATGFTTRSDLGPAREGPSEDQIKEALAKRAAQLGAAAPTAYGVPEKKDDDDDDERFQDPENEVGLFAGGAYDKDDDEADRIYQEVDEKMDKRRKARREARLKTELEEYERNNPKIQQQFADLKRALGTVSDEDWANLPEVGDLTGKNRRNKQALRQRFYAIPDSVIASARDSGELGTTVTDEPDVGDVSDGTMTNFADIGAARDKVLQVKLDQASLGTDSVVAGNATNIDPKGYLTSLAKSQINEGEAQVGDVKRVRVLLESVIRTNPKHAPGWIAAARLEELAGKIVAARNVIARGCEFCPKNEDVWLENIRLNNNYNAKIIAANAIKNNDHSVRLWIEAMNLESESRAKKKVIRHALDHIPQSVMLWKEAVNLEENPDDARLLLAKATEIIPLSVELWLALAHLETSENAQKVLNKARKAIPTSHEIWIAAARLQEQMGNANKVNVMKRAVLALAKESAMLKREEWITEAEKCEKEGAILTCANIIRETLGWGLDEDDDRKEIWMEDAKASIHRGQYGTARAIYAYALQVFVNSRKLWLAAADLEKNHGQKEALWKLLEKSVEACPQSEVLWMMLAKEKWQAGEIDNARRVLGRAFNQNPNNEDIWLAAVKLEAENQQSEQARELLKTARQEAPTDRVWMKSVAFERQLGNTEGALDLVNQALQLFPNVPKLWMIKGQIYEGEGNLPRAREAYSMGTKACPESVPLWLLYSRLEERAGNLVKARGVLDRARLAIVNSPELWTESIRVERRANNIGQAKNLMAQALQQVTNSGLLYSEAIWYLENRTHRKPRALEAIKKVDNDPILFVTIARIFWGERKLEKAQNWFEKAIILDSDLGDTWAWYYKFLLQHGTEEKRADVLSKFILNEPRHGEVWQSVAKDPKNARLSLEEILHLVIGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD88</accession>
    <name>A0A0B1PD88_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD88"/>
    <dbReference type="STRING" id="52586.A0A0B1PD88"/>
    <dbReference type="HOGENOM" id="CLU_060944_3_0_1"/>
    <dbReference type="OMA" id="KARCAQC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="109" mass="12275" checksum="C66BDC71D4023208" modified="2015-03-04" version="1">MPFKEGDYKKGAGLFKQRCASCHNLKEDDSKKVGPSLIGLFGRKTGSVEGYSYSDANKAKGIIWNEETLFTYLENPKKYIPGTKMAYGGLKKEKDRNDLITFLKKDTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEB4</accession>
    <name>A0A0B1PEB4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative proteasome activator subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g3000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000307">
        <property type="protein sequence ID" value="KHJ35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PEB4"/>
    <dbReference type="HOGENOM" id="CLU_000772_3_0_1"/>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="11">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="10">
        <location>
            <begin position="383"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="9">
        <location>
            <begin position="1854"/>
            <end position="1942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1942" mass="221682" checksum="3A47CC95285541F7" modified="2015-03-04" version="1">MGDETCRYGQKNSPPLRNLQSECIEELLSDMIKSGLSVSGGPFNVDKDKPYKPRTFPYSRLLPYNVEEEVQRIKALEEILKQLYISVKAQDIIPGALHWTRELRAWISLKFDLSRRLRSRLAKLYFSLALAPGMDRAAADRFESMFRLLLKKKRYLNTSEDLILDWKPIWRELKAFILPHEGGQHQSAFGRKRGYKSLAMLCHNAASYFEPRERKAILEEILPYFTTSDVTGAFISIGSLYMLLPSEAALDGGDLATQDYLPTLFHLWSLVNRSNIVDITFIDVLSRIARDHIFHKHVPFSEHGIFTKDQSDFFFTAILRLTDIPVGQASSPYSSSVDLAAGLGMFLEKIKKRTPVAYSIARWIIMSLSPLCLDNPSSVLSNLQGLVESIETFFHPSNHGNWSEFLAQVIYNLVYFFVMRWNREKNGEFKIPPERRLNDELKKKFVLSLREIVFVGLFSKKAKSLNYFYSAFQGLAYLEPYLILPGALQRFYPSLQGLVEVHRTQSSLCGLQMVANILSQHKGLRCHITALLALALPGIDANDLQKTLYTLNFITAVAYSVPFYDLTKGNSDSSLAIEWVQGEMERMENEGPNIEIDYRTELSDEDEANILRSSTASFGEFVLSLLGKIFTLLENLPEISRARSGAPEENVVNTLPATMTPLFASLSSDIFDKALDKIAAFVGSHVIHQARDAMAFICNSLCKANPAKTLKVFIPMLIVSIRNEIDYNEAASDRSSGTDVLPRDRALVWHISMLSMIVVHIGNSLMVYKKDLFDIALYMLEKCKGIPTIHVSNFIHHLLLNLTLVYPIDVAMYEAHIFKRGLDISDWTRLTNPSELEIAWHCPTNEEIEFAIELFESQVKTAIDRLTNLISENPSISRKGTNKEWSDEVSRNISHLRLIISGIASLFDPKNVSGFDSCDIQHNKELIEEHDHFLAGAAEDEEIQPRINYRAGYLLDEGSEAYKKIHKLREEIGRLLSQIHIFLSFEQEDDVACFSALYQTYRAWITDVGNERSAHALERMVKLYNSDIRPFKIDGLRKAYPRSLLVKRAGIYHLQRVKHNSSARHMSKLDNQLLLDLASSCLSLYAEVRINAQTALESALKSLIGGRTQVIPHLVEAFSQALDDNQYDKIKGCLYTLFYLSLTKTISKDWRYAPTVVELYIRTASVDKISIQKISANALYGGLSEYGKLHDHYVAYENVDIEVFKPKDDTSAEISSKKSTILKRRINVEKKKAELALKLVEISKKSHWKIALRCTIFALNAGLRVQNLAPPPLIELFVNGCVDDHPSLRASYSETFLRVFNFIEIRGLYGHNFERFIRDEENTVNLINVPVPKDNPNWTKEYLDSFGKPGVPEYYVDRDFPGWLVWGKYFRASRSSPLPITDWDKLESDVRSQIGLLITRQWYSKFFAFMKQEPRDSSSDRFRVHNTVLLVHIFDLTVDGITAATFEDIKELLKETYGDGTDKHQHRAAAEIIGSLLICVSGNTIEKRNSVWSFAVPMLLKVFSDGLTPENIAYWMTCLHMVIGGRDPRRAHEIYDELVSFRLDMSSNAAFKESSKVQILEFAIQDAGWHFRAEKPILEDFITHINHPYKAVREAMGRTIASIYRTRYFEGFMDIDKLLKANKSSSSLGIKPYTPTEEFTITIKDVFNRIEKWRLEREPGQHTPSSYTSGSKTVLLWLDTTLQSYECTHLTKFFADVFMEPLLHMMDVKEDPELQRLAYLVYRHLPNIPFYVGDDKDFVSALIRIGKVSSSWHQRLRTLINMQVIFFRRIFLLQAEQKYALFNAVSDMLEDPQHEVRVGASSTLSGMIRCSPVTLRDKVLFSLKTRFTESLKKNPMPEKTPGTNTPIANNQQIIRRHAAVLGLGALINAFPYTTPPPIWMPETLAILASKAANDPGSIGRTVKQILADFKKTRQDTWITDQKYFTLEQLEDLEGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEJ4</accession>
    <name>A0A0B1PEJ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000548">
        <property type="protein sequence ID" value="KHJ35064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEJ4"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="22328" checksum="759B6C41BA1BE862" modified="2015-03-04" version="1">MGSFCQELNWKQPLTGSVLIPKVTAVIRKEQGDVEVSKTILADEVERVYSVRPAHLKLYGRNKAETPHRTWMAFFSKAPHSSFKVFDESGVARPFKKQQLLDFCRRCNGHHQTKNWSRAPSCGNCCSTNHSEERCMAATKCRNCGGPHRSDSRRCLARPTRLGAPRKEQMKTFWQVGEREYQAVLRAKAAEESATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEK4</accession>
    <name>A0A0B1PEK4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative px domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000434">
        <property type="protein sequence ID" value="KHJ35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEK4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEK4"/>
    <dbReference type="HOGENOM" id="CLU_007315_0_0_1"/>
    <dbReference type="OMA" id="INGWIIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="137"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="524"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115520" checksum="92BCA7BBB0F4D9A9" modified="2015-03-04" version="1">MNGIVKDKRDGTSSRTDDTVNNSSPSHPIMNLEDIINSVLQFLSAASTEALVGVAVALTTLTYFVLGRIGLILIGGFAGVLLHATWEARNTGDYTSIRREHSLDVIRRLLDFREHNTKDEIHQGKDEIATYNFESFQPETAAALRELVDAVIRDYVNWWYHKILPKDTTFTAAIRQSLLRIIISIYLHLSKKRPEDIFLDFLTNSSSVMIVFLGELSSALTLSPGPATDAVHSYLFANPESSLANALDEQNQKKKLKMTAADIIENFVEKSVLDCNPLRIFLTEILSCLVLESVLKTCSKPEWINGWIVFLLEKGESDLSQAIDAGMNKNQQDGISEGNTKNLGHAGSAQKSKPNVNQEQQGSQKHNRLSRTDEDMDKALEEAKRLSELIAEDDAKKKNNHTLPNPKTDILVVPLSQADVNIDLDLETIKTKSNKVSSKNDHKPVSATEVPKFTESPHLSSTNHEKSGILSESQDPSTTINISHSNSSFTKLDQLSMDCSSGNRDSSSQMDKKVALMTLHNANVTVCDNNSNPEKGKMRSKPSFDFLIQIEPASSSHPGWMIVRRYSDFETLHEVLRRIAQISGVTFFTEQHQTLPNWKDFTKETLRVELERYLRDACWYQPLAESEGMKRFFKKDQEQQILSSKNNSFPGLGWSTPSAMGKGVLDALAGAPKGVAEGSKAITGVFNNIGNLGQKKLNSAQVEATLGKGSLSNMNPLQASRVGEDIYFSSSIGQTQSNKSQLLEQRPGYDLMAMDEDHQTHESNSTSTRSSVSGRQSPDRNQDSTRNSSQRNTANSSPIEFSIEALKLPPPPTEMPDDYCSRSVNGSIAGHSRSGSNSASARTTTSGTGTPRHLQNSSGHKRAKSSRSGSMKTRKSRKASKPLTEAETRVAVELIFAVINEIYTISSAWNIRRTLLTAAKTYFLRPGNPSLLQIQSLVQESIISANISDTGIAAHLHKIRENCLPSEDELKKWSTKMSPENKERLRIKARSLLIKRGVPIALTGVMGQAATSEAMGHIFDYLQIEEVTRGLIFGILLQGIRAVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEL7</accession>
    <name>A0A0B1PEL7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000431">
        <property type="protein sequence ID" value="KHJ35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEL7"/>
    <dbReference type="STRING" id="52586.A0A0B1PEL7"/>
    <dbReference type="HOGENOM" id="CLU_004757_1_0_1"/>
    <dbReference type="OMA" id="NRHPQKA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="12"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="701" mass="78766" checksum="FC8DDDEDA3CDDD15" modified="2015-03-04" version="1">MENHRKEKNTSLFQVFLRLRPPPTLSHSVTSPERILTVEEPSSEGTSTSVVLTPPNDNRRKAVEKFTFTQIFKEDANQLDIFHGTNTLSLIERALGKNEEGKDGLLATLGVTGSGKTYTMFGSRSQRGLIQLILDVLFRSISKNMYLDTVDKSLHASVAAADSSEAQIISAQNFLETIYPDLTNASRAGSRAQTPISRESNFSTTPRRILPQSSMPCTPDISHVTAQCDPNAQYAILISMYEVYNDRIFDLLAPALPTKSTKEYRRRPLLYKHTENSPHKKVVAGIRKIICVTNKEALMVLDAGLHERQVAVTGSNSVSSRSHGFISIEIKKRKSNWVHGQWISSSLTIVDLAGSERARDAKTQGATLVEAGKINESLMYLGQCLQIQSDMASSTKQNFAPFRQCKLTELLFANCFAHTNNGNPTPLFHHNPQKAIMIVMADPIGDFNATSQILRYSSLAREVTVPRIPSVTSTTLSHSSTDSHTLNTTRTLSSRLNPNESERATMEIAALEIARMSDEIECLRVELEGESMRRAEVEAHAEWLSNCLVEVEADIREECFRDMEERIETEMRRWKATWELEANLKDEHLDRKLEIYTQSIAAISVKDEEDKENTHNGTREDLEAENLRLKIEVEKLKREIQGRSPSKIKRLPLQEKGSLMSDSRPRDSASSNILKSKYLSPTKKPSKSTSQKWKSLQDDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PET9</accession>
    <name>A0A0B1PET9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01000390">
        <property type="protein sequence ID" value="KHJ35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PET9"/>
    <dbReference type="STRING" id="52586.A0A0B1PET9"/>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="580"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="882"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118352" checksum="EFDE2A22CA837E5D" modified="2015-03-04" version="1">MAIQALVGQYARCQVRWTSSKLKLANFHLAHDHAIKVNLKSSKITLTRQELHTSSKKTIHSKNRSDAAHNGSFLPLDTFARRHIGPSEESANMMLKKLDPPAENLDDFINQVLPANILLDTKLKIDTKLSANKEAFTETEVLDLLQKKMESEVSSTARSYIGCGYANTIVPGVIKRNVLENPGWYTSYTPYQPEISQGRLESLLNFQTLVSDLTALPIANASLLDEPTAAAEALTLSLNSLPASRQKDPNRTFLISDYVHPQTKSVIQSRADGFGIKIEFGDVLANNFHRVKELGKSLVGVLVQYPDTEGAVEDFKGLSDIIHQHGAVFSVATDLLALTLLTPPGEFGADIAFGSAQRFGVPLGFGGPHAAFFAVDEKYKRKIPGRLIGISKDRLGNRALRLSLQTREQHIRREKATSNLCTAQALLANMTALYAMYHGPNGLREIAQKVNTGARVLEEGLRTLGLETGSRGIGEDNKVLFDTVVVKVPGKAQRVLEIASSTHNINLRLFDEDRVGVTIDETTSAADLEDILSVFSIHLDKKETQNFQVNYLLESLHKSSSLEIRSKLKRSSSFLSHSVFNTYHSETELLRYIYHLQSKDLSLVHSMIPLGSCTMKLNSTTEMTPVSWPQFSNIHPFVPISQTKGYLSMIEDLKADLVEITGFDAVSIQPNSGAQGEFAGLLVISEYHKQKSDSKRDICLIPVSAHGTNPASASMAGMRVVTIKCDTKTGNLDMADLKQKCEKYKETLAAIMVTYPSTFGVFEPEIRSVCNLVHEYGGQVYMDGANMNAQIGLCSPGHIGADVCHLNLHKTFCIPHGGGGPGVGPICVKSHLAPFLPGHPLIKTGGIQAIPPVSGAPYGSASILPISWTYIKMMGGRGLTHATKITILNANYMMSLLRPHYPILYTNSNLRCAHEFILDVRGFKETAGIEAIDIAKRLQDYGFHAPTMSWPVANTLMIEPTESESKEELDRYVNALISIRDEIRDIEEGKVPKDINLLRMAPHTHEDLLTTEWNRPYTREKAAFPLPWLKEKKFWPSVARIDDAFGDKNLFCTCSPVESLEELDKAGDINGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFA5</accession>
    <name>A0A0B1PFA5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000171">
        <property type="protein sequence ID" value="KHJ35995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFA5"/>
    <dbReference type="HOGENOM" id="CLU_323942_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="102328" checksum="58C13D3D5902E002" modified="2015-03-04" version="1">MSFDIDYCSMNDQQLPIGEEKMTPKEIETIARDQSRQISFFSDLSPANITSGKEIKDKNHDNNQKEKLVSDAIHCSQVDSKSNSISSKSVIYPRASDQIFNFEISSKDILKKGTRTEANIDLCTQYNRKKTSSPFPKLRIFPQRIETSKIASGEILSPSNQNVSISLSSLKYQNFKENLNENSLEILKEPTYRFETVDESLQQDSELTKCGITIEDKIGQMQRQESRLITHNLMAPVSYKSRSSASHTSSFLFKGKSLKKMSIKLHKKSPMSKKLNKMNQQNVEYQRKEFQKKMIVIPNLQSSKISLKNIDLNLEDDTTEEWETIKTKSCNSSTDLSGLKMKKEAMELKKLGTSINNKNSISLNNLAERFVKFKDSLIRDTSIFKKPYYNQTTYTPYSVEIVDVDKNKKNSIFKEPILDEYQFSKLEVDSHDQKSYGSHSAFEKDQMSDTSLDLTPQINISNSGYVDKSLLDFTTNSKHSFSRLHKYLSECFTRRNFINNLRKKLHCQINRNDQNISEKTNICNDLISRLYSDRDSLASSTQASFGDLNKVCKRYIINDKSNFYCGNKNSSSLDIGFKKFSECDYEDGILSIGYLPENEYIVACYDDGPRVFSYGKSYSISDFGSSSINSQVDLYSDYKSHPIYKNPYDILSSSKLYGQIKSQRRKEKSSARLPFKEHSNLSSTDLSSSLSLKDTTWKRKMRPDSQLLANCIRVGMEYPKKAYFKGYFSHEPLSMNPPLKKEWKLMYTPSELHSLENGGKIKKKSNTCHSWGGTTLDSDIKFGKNNFQQLTILPSRENQGDVHKDIETCFDDKSKYDGKKISIILLITCISFPPVLFPIYSLGGFDYFISVITNGEISQCNRTQKYWALWAWLPSWLIGMVLLGICIQWIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG08</accession>
    <name>A0A0B1PG08_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000105">
        <property type="protein sequence ID" value="KHJ36225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG08"/>
    <dbReference type="STRING" id="52586.A0A0B1PG08"/>
    <dbReference type="HOGENOM" id="CLU_046578_1_0_1"/>
    <dbReference type="OMA" id="TGLMKQY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="93"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39500" checksum="67BA0B2BC27B5B33" modified="2015-03-04" version="1">MSQNEDLSFPIKSENFSNSGAHNSKVSDAYAPGDKYSQNSSFSQSMANGPVVENIKEQSAKTQADLSNLAATRTTPTYTAATGQPLTQYHSFFYSLLSWEHPRASGIAYLTSVLIIFATRYLNIFRYSLKVTYVVLGITLLSEITGKLLFSHGFTSQIRPKRYYTVSRETLNLLIGDVHELINFFVIQAQQIIFAENLFVSLAAFVSAFISYFLVKFVPIWGLSLLGSSALFLGTLAYKSNQEFIDNNIEYSANIINQQTEQIKVLISDYAAHTTKQTKALVGDYSVRAQEIITSRSPLSSPRASEKKAKNATPGKETYLKSEDFPKVPLEDFKSVKNFDSQSPLRDEQNLIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH80</accession>
    <name>A0A0B1PH80_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000222">
        <property type="protein sequence ID" value="KHJ35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH80"/>
    <dbReference type="STRING" id="52586.A0A0B1PH80"/>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_1"/>
    <dbReference type="OMA" id="ISTHPCL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="26315" checksum="C0603C3803F4B8C3" modified="2015-03-04" version="1">MAKPLPKNVHISKHPCLRAKLSQLRDQSISARETRTLIHEISLILGCEATANSLSVTEDMEDMKTPLDHAYTKQTISPKNISIIPILRSGLGMLDAIQKILPNAVPVHHLGLCRESTTLQPVEYYSNLSFNIPSISNERGPRSSDRKSPTTRSLAIVLDPLIALGGTCTATIRMLKGWGAQKIIIISLLGARQGIERVAREWEDGVEIWLAGMDEHVNERGTIIPGLGDIGDRLFLTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHD2</accession>
    <name>A0A0B1PHD2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000101">
        <property type="protein sequence ID" value="KHJ36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHD2"/>
    <dbReference type="STRING" id="52586.A0A0B1PHD2"/>
    <dbReference type="HOGENOM" id="CLU_341368_0_0_1"/>
    <dbReference type="OMA" id="LNEWCKN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="655"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="831" mass="94510" checksum="5E05FC4F24979B84" modified="2015-03-04" version="1">MSTPNPNSSSINNSPFEGAQITEAKDREFVIFPERGGTGIVGNGRTTLVQEKFLSWWKTTNYGSGRNRLPSSVPNRRGLTIGLDKIWITSTRGHIWPLFRQLAALGNGEPKVQCTICEAVLQHPKATHQGSGSLTRHVQGQHPTLTTPGPRTSNAHRLLVDQTILPNTHSTGSCPPENLENTERDRRRAFLQFGLAKKLPFNWAEDPATAALISRLGLQIRPPGRNELKSELESHFSDVQIRINQALKTRFKASIAIDIWKSSHHLNFLAIVAYWIDKDWKFHEALIDAPLISECAPSQEIGKSIINVLYKYKLHSRLLGVTSTEDDKLVCALGSLEGILGEKNIRWKTADSALRCIAHAILLAANAFCQSLKIQTIKRDKEIPKNVCNATDLSSNLEPAITVSKIRSMIKLIKSSSARFNRFKALQRAENVQIPLISSGNFTAQWISMYWMITYAYLNQTIINKWKDQEVEYTHDPNIIQKLHKLTITSEEWYHVRLITSVLKPLVTLTDVLLRTQGPLIHRSHVFLSAIFDGLKSKLSMHMHNTCVSGKLKGEIVSALEAAIQKIEIFYHGPDGSPKLLYNLAMILDPTRKLLLFQEWDNHENSSTEKYQKMHRKEFIDYFIENYQHTTSSPPEIALFRPSFQVRRSLETQAMRYLDSEVVDDDGGEFNLLNWWQKNEKEYPELAKMAHDVLCVAISGIGVRQIFNQGRDIQNYIEARLDGEAISKALVLVNALGQTTASLEPRQRRPHLPDDPDDLFDEEDLKENPALEFNQEDINDDDEFYSNNYDDNDNDDNDNEDEDNEEDEDEEIDDTQALFKGETNLFDEKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIE0</accession>
    <name>A0A0B1PIE0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000100">
        <property type="protein sequence ID" value="KHJ36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIE0"/>
    <dbReference type="STRING" id="52586.A0A0B1PIE0"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="306" mass="33631" checksum="CAC5EA11C6E5DD09" modified="2015-03-04" version="1">MAPPALTKRALPPDPPDVGNRVSKPTSTLNRSNSIAISKAHSTRHTKAALQKSSTLEKKLGVVQFSIDEQDEQDDEDLEMDAVTGKPSTYTINTDPFDEDFPPLTGVSELNAVKITQNEDNVNETKKKKNATSLMDAIKSLLDLTNPFLQKLEEDHPGVGTDFIALLADGASRAIRGERIYTSLQKTSPIYSKVLKPTWAEKAGVLENGQKIPLKKQTIRATPPHGQSKEDRRVIIRLSPDHEARKISSFELRQKIQLLIPDKTLIADVWTVPSGVAILAPTPAKAAALLQFKEVIENRFGDACVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIW3</accession>
    <name>A0A0B1PIW3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">EV44_g2394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000027">
        <property type="protein sequence ID" value="KHJ36424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIW3"/>
    <dbReference type="SMR" id="A0A0B1PIW3"/>
    <dbReference type="STRING" id="52586.A0A0B1PIW3"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="OMA" id="DIMSIPR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000034">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="256"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="440"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="481"/>
            <end position="484"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="589"/>
            <end position="590"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="595"/>
            <end position="599"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="679" mass="77732" checksum="3403545AF6B9698A" modified="2015-03-04" version="1">MDSSSIFENQYDRSALVLYGSETGNSEDVAYSLGNMLERLHFTTRISEMNCIEINDLIKYSLVILTVSTTGQGEFPRNARKFWKSLLRKSLPKDCLNGMKFTSFGLGDSSYSQFNYSARKLHKRLLQLGAKELFPAGEADERHPEGNDGTFLSWSHELREHLLILFGLPIVIDHELIQKRSLTKNFDLNEDHSNLICSLNIGADTEPSINGFKKSFEAEKSGIQKIKSQDCILDRNLEEANAGAHNSELNKHIHLPNGYRASLKSNVRMTPEDHFQDVRELIFTIEDSIPYEPGDSIIIYPKNNPDAVGRLINIMGWQTIADKPLNFHPDHPSYCGDEWLSIAVPHLHPVSHSTLRQLLINNLDITAIPKRQFFEVIAHYTENPTHKERLLELANPIFTDDFYDYTTRPRRSILEVLEDFSSVQLPWQYATSIFPVIRGRAYSIASAGTQEDVTKSSKFTHVTILIAVVKYKTILRKIRQGLCSQYLASLELGTTIEIEIYRSKSFYNHARIHPQTPLILVCAGTGIAPCRSLILTRKNLQFHFNLLKRDINIGNHHLFFGGRNRKADFYYEDDWKKKIMRTTVYPAFSRDQREKIYVQDTILEESELVRNLILHHGAIIYVCGSSGSMPKAVKEAFISVLLSWNLNSSVLKESPMTRELAQKIIDEMIRTGRYVQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUL0</accession>
    <name>A0A0B1NUL0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005414">
        <property type="protein sequence ID" value="KHJ30057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUL0"/>
    <dbReference type="HOGENOM" id="CLU_043418_1_0_1"/>
    <dbReference type="OMA" id="QANEKFY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="326" mass="35879" checksum="4A606BBE8F1AC54A" modified="2015-03-04" version="1">MALLSTILNATNFRNPLLRTIIPAVGTAYTIQALVAIPSILNETERFYDLSGSLTYLSVTALSLYLPTLRARAAAKLTSGVKPVFPSLTRAFFEYGASNGFNWRQVVLSAAVSIWASRLGTYLFKRILADGHDSRFDEIKRSPLQFLGAFFAQATWVSLCLLPVLAVNSIPNNLLSSLPLIMTSDIIGLSLFVGGLAFEIIADGQKNAWVQAKKRKEHDEEFLTSGLWSKSRHPNYFGEATLWTGIATTAAGVLVSRVGQSVIGLNSVYGHILGLGLTFISPAFTTFLLLKVSGVPLSESKYDKKFGDRYDYQKWKRETPVFIPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVV2</accession>
    <name>A0A0B1NVV2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM5</name>
        <name evidence="11" type="ORF">EV44_g1561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004112">
        <property type="protein sequence ID" value="KHJ30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVV2"/>
    <dbReference type="STRING" id="52586.A0A0B1NVV2"/>
    <dbReference type="HOGENOM" id="CLU_076902_6_1_1"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="105" mass="11283" checksum="F9031CB54C1F7464" modified="2015-03-04" version="1">MASQLLPLELIDKCVGSKIWVVMKGDKGKNLLAAIDENLICLEFCGVLLGFDDYVNMVLEDVTEIDYSGGQTKLSKILLNGNHICMLIPGGEGPTATALVANNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW03</accession>
    <name>A0A0B1NW03_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004957">
        <property type="protein sequence ID" value="KHJ30153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW03"/>
    <dbReference type="HOGENOM" id="CLU_1349785_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="24025" checksum="35A08A2E5B0197DC" modified="2015-03-04" version="1">MSIHGYIREYQKRLIDVKEHSKITPDIENQMKFLLLSYIVKLEPELSNRCRKMTHDDIISECLQWMSTNKNRLSDSSDKTKCEKDKSDKGSSFSIEQIENLYQEEYDPTVHSTSIIRQFCNYAFKAYVDSELKDSTLASQFALDFMKFKEEDFDKIRKEDITKYLQFLRKNGVYVNVKCFVKVSKTLADIIEHDRSWPDNDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW91</accession>
    <name>A0A0B1NW91_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">EV44_g1444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004703">
        <property type="protein sequence ID" value="KHJ30233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW91"/>
    <dbReference type="STRING" id="52586.A0A0B1NW91"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="378"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="52491" checksum="EC69FE02CF889F0A" modified="2015-03-04" version="1">MEEIPIQSKINGQVQVYFTTSSKDIELNEEKRQLLVPSNVQRYGLSMILNSESMLNTESPIPFDFLIDGNFLRTSLEEYILENGLSPEITLNLQYVRSLIPPSFEASFEHDDWVSCVDVLSSSSKAGSWGSYKRAVDQDLILSASYDGLLRIWSKSGQNISTSAGSDLGGHTSSIKTAMFMSPTQVVSGGLDRTIKVWNYKETENKFSGELKPSLELLGHTGSIESIDFHGPSGRLISGSTDGTVGVWSSSKNDAPVAPESLLATRSNVKRRKVTDSTSISRCGPLSILSSNKGPISEVIFNPLDHTVAYSASLDHTVRTFDLSTSILVDTRTTLNSLLCLAALPGTSTQLLAAGTSARHIILLDPRVSAKSTQVMTLRGHSNKVVSIAPDPESNFGLVSGSHDGTCRVWDLRSSRIGTKDEGGGKVCEAVYVIEREGHKGKRPVGGEGVKVFGVKWDKEVGMVSGGEDKRVQINHGRGVTKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWG8</accession>
    <name>A0A0B1NWG8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003721">
        <property type="protein sequence ID" value="KHJ30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWG8"/>
    <dbReference type="STRING" id="52586.A0A0B1NWG8"/>
    <dbReference type="HOGENOM" id="CLU_012368_2_0_1"/>
    <dbReference type="OMA" id="SVYESCP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="589" mass="67360" checksum="593CCF909C59714E" modified="2015-03-04" version="1">MCGIHFSLSQQEFCCPNDQLIQLLRNRGPDYINNERVRVPRKNGNDYYISFTSTVLGLRGEQVICQPFKNKAESLFFCWNGEAWKINTHVIVNNDGKVIFDLLQKASSIQSTSEATVEVLRTLRSISGPFAFVFYDHIHRQLYFARDRLGRRSLLYKDKNDNTLLELCSISDPLDGSWEELETDGLYQLSLTEDQSLAKYHFPSSLQPGKFLSGLQNHKWFNTKDLNCFTKWEPNLGVFNMSIPTEQYVMNTDAKSVETLHKLLYKSLHLRILHIPPPSNIENASHVRVAILFSGGLDCTVLARLADDILPHDQEIDLLNVAFENPRVIQAAKNVKLPTKDKVFNEIEDCPYESCPDRKTGRRSWEELQKVCSKRVWRFVAINIPFSETMAHRQILLNLIHPHNTEMDLSIAYALYFASRGSGLASLNNQMTPTMYATPARVLLSGFGADELFGGYTRHTTIFSRTGFSGLLNELKLDYDRLGKRNLGRDDRIISNWGKEARFPFLDERLVRWAIEAPVLEKCGFRSPYNLDNTECPNLNLEPGKLILRLLSYKLGMIQLSTEKKRAIQFGARTAKMRTGKIKGTTLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXB6</accession>
    <name>A0A0B1NXB6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 50s ribosomal protein l13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003856">
        <property type="protein sequence ID" value="KHJ30628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXB6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXB6"/>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="OMA" id="MNTRHTA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="120" mass="13750" checksum="92122E8F8632EBC2" modified="2015-03-04" version="1">MGKHKPIWDPATDCGDYVIVTNCSQLYTTGKKRWQKKYYRHNTRPGSLQTLTMYGLMAKQGGAEVLRKAVNGMLPKNRLRDDRLARLKAFEGERHPYNANIVRFCGVKYGAEVFNQAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXD7</accession>
    <name>A0A0B1NXD7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003815">
        <property type="protein sequence ID" value="KHJ30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXD7"/>
    <dbReference type="STRING" id="52586.A0A0B1NXD7"/>
    <dbReference type="HOGENOM" id="CLU_046747_1_0_1"/>
    <dbReference type="OMA" id="IMRYFKW"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="373" mass="42863" checksum="6E41E442A9DE7BFD" modified="2015-03-04" version="1">MSPDEAPPYFPSLQWRFLSSVIMGVTGSMSRIFLYGLSGLEVIGLEKFLEKIERRNDIEGRKRGLVTVSNHISVVDDPLIWGVLPFSHTFNPSNLRWSLGSYDICFKSRLLSAFFNFGQVLPTHRSTHSKYGGLFQPTISQAIRLLSAQPFTPPVDSNHLEFYDPFTTGSMTYTTTGSDLFPSPSYYPSRKYSWVHIFPEGRVHQHPHRTLRYFKWGVSRLILESEPMPEVIPIFIDGNQEVMAEDRGFPQFLPRTGKHIRIAFGEIVDGEKVFGELRERWKQLVQNQKQILQEKGINVQWEMGELSDDLKFGNEAVEIRKEVTNRVRNEILKLRRSLGYPDEDSKQGLMETWIKEGPKLTGKMDDGSWVGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY79</accession>
    <name>A0A0B1NY79_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003456">
        <property type="protein sequence ID" value="KHJ30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY79"/>
    <dbReference type="STRING" id="52586.A0A0B1NY79"/>
    <dbReference type="HOGENOM" id="CLU_056971_0_0_1"/>
    <dbReference type="OMA" id="EEFVQWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="172"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="32547" checksum="B7D655538199D59C" modified="2015-03-04" version="1">MSTSPTSIPSNSTQSTHCSNDNVENANITFESICTQISHQVNAFLEDEATTPLLRRVQAQMRITLGVIHKALKQYSLDEISLSYNGGKDCLVLLILFLSAIATSGVGEPKTKQTLSSPIFSKSKISSLFPHRLHSVYVMAPHSFPEVDAFVTTSATAYGLDLVRYSLPLKAALTRYLEDNKVIKAIFVGTRRSDPHGKLLTHFNETDNGWPSFMRVHPIIDWSYSEIWAFILHFRIPYCTLYDQGYTSLGGINDTHPNPALRVDNLETYKPAYELSDDDAERLGRNDYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYV8</accession>
    <name>A0A0B1NYV8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003178">
        <property type="protein sequence ID" value="KHJ31168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYV8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYV8"/>
    <dbReference type="HOGENOM" id="CLU_002055_3_0_1"/>
    <dbReference type="OMA" id="TSEIMEP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="562"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="935" mass="106322" checksum="669392BA9DB32AC3" modified="2015-03-04" version="1">MKYSGQCDNLDCALDDVHEMCSIAGVPDIYKCQAFHIMPKDSAKLFYSENIRDKIFYFDGMVQALRNNFETPELQREMQSSFNSLTLSKILIINKGLKTKPECLDELIREIQRLYRGLPTYNRTSESKDFELRNKLLAACEEDPDCSMACMLPAKTFQALISQLRTSISLSLKVQKSQQTAYYTANGYENDSFYTDRQYHGQKRSQTSSSANNKEQSKTKFGKKACFVCSKEGCWSTRHSPEERMKSMADFKSKTLRLTGRKYTGPEIRQFLNDFEGLEPAQEIPDNFSHFHVTQDDEESDDLEDFFRTGIFFTDSQTETTLEAYSDFFPTLRGNVDGYTTVGSLRDKSIEHLLTQSRSCPGSRYSSLKFEGILIDTGAAKISTAGYNQFLALKRLRPSLKIDNSRAGEAHITFGIGSTSSLGTTNVDTPVGTITFHITNSVTPFLFCLADMDNMKVHYNNLTDLLIQHSITGEENTYPVIRKYGHPFLLLGGPEENLVHSFEKLNGIIECHLTDTELRRLHHRFGHPSTDRLTKILSRSGHDFNRQAIKHLTKFCDSCQKYSKSPGRFKFNLKDDRNFNSCVYIDVLYIDEKPVLQVVDEATCFQAARWLKSMNAQEAWNSLRNCWIDVYLGPPDVIVHDAGTNFTGKEFKQSAIAMSITTKVAPTEAHHSVGLVERYHTPLRRAYEVISKDLGGTKTDRTSLLQMAVKAVNDTAGPDGLIPTLLVFGAYPRMTESDPPTPSIFERAAAIKAAMKEVRKIRAKEQVRNALKMRNGPKTSELKDILPNGQVLVWRENKEWTGPYKLIRIEGEDCVVQVSDHMPTFRSTSVKPYYSDLNTQNLNDPPLNEEPVENVSSVNKTSEIMEPRRSNRVRKSRDFGNFFVSICDLVNISSFNTSSFLSSKKWPIEKIRFVCVQLVRLLRRESLSKPRARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZA3</accession>
    <name>A0A0B1NZA3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative egh16h1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005608">
        <property type="protein sequence ID" value="KHJ30021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZA3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZA3"/>
    <dbReference type="HOGENOM" id="CLU_047729_4_0_1"/>
    <dbReference type="OMA" id="MRYTSIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059245" evidence="1">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="29164" checksum="E8038E3A61716062" modified="2015-03-04" version="1">MRYTSISILASFALTNVFAHGLIDSVKGANGVDMPALSVADGTPRDCASPACGSEADTSIIRSRELGTNKATALGRTQGGGPVNASKMVSMFMNGDGGNKTSDKQAREIHAANVLRRSLGVRAENGGTKTPKGTVETGVKAAAGAGSSSGMPTCAEDGTVKMTFHQVNQDGAGPLSAMVDGTSGGMDPKAFQKATVTKNVPGIGIGGLSAAAVMDFPVEAKMPDGMTCDASVGGVQNVCVMKLQNKAAAGPFGGSVAFTQSAKAKKRAIELRAQLPRPKMEKMRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZF0</accession>
    <name>A0A0B1NZF0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002994">
        <property type="protein sequence ID" value="KHJ31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZF0"/>
    <dbReference type="HOGENOM" id="CLU_066070_0_0_1"/>
    <dbReference type="OMA" id="MDVSYEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="234" mass="26481" checksum="904EE73A8844D5DF" modified="2015-03-04" version="1">MAPIRRYVRITKYSVLECRIFLDNPNLGESWLSNPRTEILPRVMKSVFPLITPKLREEYERSKNKSTKKSRIKDIVVEGDSTEDDIACDVDIPSINIENEECNGSNLCLHELPEASKNDWTSSLDQSAVDLGQQEKRKRTRDARSLGSSSSDVESSCKKPKNQDSSGSEEELEDKKMEIRTTYEGFTIYGRVLCLIVKRRDGSGKASSEPIGQATMENWISSTQLPLENEELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZI8</accession>
    <name>A0A0B1NZI8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZI8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZI8"/>
    <dbReference type="HOGENOM" id="CLU_115913_0_2_1"/>
    <dbReference type="OMA" id="NEDCVEE"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="133" mass="15040" checksum="A8E16D9BB3D49C33" modified="2015-03-04" version="1">MFEMEVSSSWSDIIQAIMPWTESHAEEPVKDEEKGSNAEEKEADKLSVADAEAVEESEEEEEEEEDLVDPKDVLEEECKNSKACAPLKHHYDECVERVTSGHGVENEDCVEEFFHLLHCASTCAAPKLWKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P016</accession>
    <name>A0A0B1P016_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc knuckle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004899">
        <property type="protein sequence ID" value="KHJ30169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P016"/>
    <dbReference type="STRING" id="52586.A0A0B1P016"/>
    <dbReference type="HOGENOM" id="CLU_059403_0_0_1"/>
    <dbReference type="OMA" id="RPVRMQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="32298" checksum="76985A011A72A37B" modified="2015-03-04" version="1">MSAVRPNGSAPKSMSTRLLTMKFMQRAAAAPVTSVPTISHEHSKIQKKEPDFNVSRQNLDRLVDQNAVLDALAKENEKSLAALDRLATESGDTRWVLDFMEQDHPMPSMSLHVVQAGYANLDNLVSQSTATDKPSGESTILGRRSFGRFNKDLEKQQNPHYCEASTSDSEIDENNDMDSYDTGNSEEDNNPTSELIKTTRREVEKADLRVKKRQAREELKHHLAKKARQAEVSLNHLTSLSGRQEVNSKSKMECYSCGGPHRKIDCPNRKRGQQCNDEGPPKKTFKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P017</accession>
    <name>A0A0B1P017_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">EV44_g0757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01004678">
        <property type="protein sequence ID" value="KHJ30241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P017"/>
    <dbReference type="SMR" id="A0A0B1P017"/>
    <dbReference type="STRING" id="52586.A0A0B1P017"/>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="322" mass="35634" checksum="BB0FE20B76579405" modified="2015-03-04" version="1">MTTKNYLVTSEATILELKKSLCSEYESLPKRFRALFSLKHIAKTELSLPALEAIAAAFSSPSALLKHEVAYCLGQTKNIAAIPHLRAVLTNKNEDAMCRHEAAEAMGAIGDIDCLDVLTKFRDAEDEDRVVRETCEIAVERILWEQKDACNEKFRNSKFTSIDPAPSKNNDDSIEHLEQELLSQKLPLFRRYRSMFSLRDLASSSRSSTATLAVLSLAKGLSDPSALFRHEIAFVFGQLGHPASIPALTATLSNMNEVSMVRHEAAEALGSLGDQPGVKEILKKFFNDKDQIVRESIIVALDMADYETSDQIEYALVPGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P034</accession>
    <name>A0A0B1P034_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002418">
        <property type="protein sequence ID" value="KHJ31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P034"/>
    <dbReference type="HOGENOM" id="CLU_2122889_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="12600" checksum="48CF4845F85FFA42" modified="2015-03-04" version="1">MKTEIAVINRITGWKTGREQPAKSKSSPSRGAGVNAQYALHIWDSQEDSHSPSLQDSHSSPQVSIVFVSTSLSPPHLFSRIPTIVPGSIECRALYFHKEPPMKVSCWRRWSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P037</accession>
    <name>A0A0B1P037_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004831">
        <property type="protein sequence ID" value="KHJ30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P037"/>
    <dbReference type="STRING" id="52586.A0A0B1P037"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="OMA" id="EWIRSAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="30251" checksum="606323C1A2EF31F4" modified="2015-03-04" version="1">MSVFDCKNADVLSPHRDCDHRINLKPGTAPPHGSLYNMSVNELQVLRKYLHDQLEKELNPDIKPPATVPVLFAKNLSGGLRFCVDYRGLNAITIKNRYSLPLMQETLSRLSKAKCYTKLDIISAFNHIRIAEGQDMMTAFNTRYGLFETLVMPFGLSNAPATFQSHINEVIRPFLDIFCTYYIDDILTYSDDLTSDRTHVNVVLDALSKAKLHCDKKKFEFEVQEVTYLGKIISTTDVKTDPQKVQCIVNWTPPHCLKDVQGFLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C8</accession>
    <name>A0A0B1P0C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004465">
        <property type="protein sequence ID" value="KHJ30331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C8"/>
    <dbReference type="HOGENOM" id="CLU_1180960_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="235" mass="26743" checksum="0ADB61DFDDB01A32" modified="2015-03-04" version="1">MTKILTKLMSTGQFTGSTDRRVFSDSQALVDEISTLRIDELEEDNVRELDRCVRNLNYIGSGYLTKNPQMVTEMITVLNSQSTIRLEEPTFIPSIRAPFSSDIFKLLSRFGPEAPSFWNDRGSEIVCKAGEKTVVTSGGKRKMGEADIYMNMPNKIMITPKPLLIDVRDLEKVIARGKVKMDVNERAGRYRHVSIEHDDTKRKLLYRLLIISIRMACQNEVSGLYKMQLVAVAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0D0</accession>
    <name>A0A0B1P0D0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="JNVN01003675">
        <property type="protein sequence ID" value="KHJ30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0D0"/>
    <dbReference type="SMR" id="A0A0B1P0D0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0D0"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="54446" checksum="9368D92899B663CF" modified="2015-03-04" version="1">MSAATGDFGLIGLAVMGQNLILNAADHGFNVIAYNRTVAKVDHFLENEAKGKSIEGARSIQEFVSKLKKPRRIMLLVMAGKPVDDFIETLLPFLDQGDIIIDGGNSHFPDTNRRTKYLAGKGIRFVGSGVSGGEEGARYGPSLMPGGNEEAWPYIKDVMQSIAAKSDGEPCCEWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRALCLSNKEIGDVFAKWNKGVLDSFLIEITRDIMYYNDETDGSPLLEKILDSAGQKGTGKWTAINALDLGMPVTLIAEAVLSRCLSSIKSERTRASKALQFVSRSTKFDGNKDQFLDDLEQALYASKIISYAQGFMLMQEAAKEYGWKLNKPSIALMWRGGCIIRSVFLKDITAAYRANNDLENLLFNDFFNKAIHKAQPGWRNVVSKAALLGIPTPAFSTALSWFDGYRSENLPANLLQAQRDYFGAHTFKIKPEFANEKYKDGENIHVNWTGRGGNVSASTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q3</accession>
    <name>A0A0B1P0Q3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01003530">
        <property type="protein sequence ID" value="KHJ30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Q3"/>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OMA" id="VWGTNEF"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="601" mass="68654" checksum="FC91E1BEC1031FD4" modified="2015-03-04" version="1">MPAVRRWRILVFSLTFALLTLYYLAPNRSLWSYCYSCHRPPVIPNNNKINWSTIPLKYPVTSYIPLPKGQPKKIPKVQASAPQETTEQRDERIRRKELVRESFNHSWNGYKQYAWLHDEVGPLSGKEKDPFGGWAATLVDSLDTLWIMGMKDEFENAVLAATSIDFSTSQDGQINVFETTIRYLGGFLAAYDISGEKYESLLTKAKEIGELLIRSFDTPNRMPVARWNWKPYIDGIPQVASQRTLLSELGSLSLEFTRLSQLTGDPKFYDAIQRISNELEKSQSTTKLPGMWPVTIDASIPSFDTYNFITLGGMSDSLYEYLPKQYLLLGGLLSQPRTLYEDFISVAKKHLFTRFYNEQNNNLTISGDVRVSGTEIHQEPVGQHLTCFTGGMVALASKIFSRPEELPLAEELTQGCIWTYDTSPNGIGPEIFTVSPCPKDGRPCIWNDDLHRKSINENYSSSESFNKTNVEQEVLNKSGLPKGFTSVQDHRYILRPEVIESVFILYRITGKQIYADAAWRMFKAVEMACRTPIAAAGIQDVMVKLDYADPDINDQKIDSMESFWLAETLKYFFLCFEEWDVISLDDWVLNTEAHPLKRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S6</accession>
    <name>A0A0B1P0S6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004065">
        <property type="protein sequence ID" value="KHJ30526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S6"/>
    <dbReference type="HOGENOM" id="CLU_1090683_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27391" checksum="950E3C98B378A28C" modified="2015-03-04" version="1">MDPFGQLKRVITRTYDYDFVDCIASSTEIPAHVSHSNGEVSTQSKGTTRSGFDCNGIFFDDKELHLARDLARESRRSRHNVFPVEHFSPPCDSPCLLWPLKSSGSTMRNGMMPCSLFLSTLDILVDIFTSGNLAPYRLVMSLDFQILFVALKGHDKMKKCEKRTIAGGNINHDQSSFRCSTTVFHNSELLPVVDKACKNKMLYSKTYPMKYEGENFQIPGPYLIYPLMKDKEYTGGCMLKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0U1</accession>
    <name>A0A0B1P0U1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell surface</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003482">
        <property type="protein sequence ID" value="KHJ30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0U1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0U1"/>
    <dbReference type="HOGENOM" id="CLU_1373122_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="21345" checksum="441000C68D7680E1" modified="2015-03-04" version="1">MSSTVNKIKEALHISSGDRDLSKNESRFSHLGKPDSISSESTRSHVASGAETGHGLGTSNTTNYTPGLNSGNTTHHTSNLANKLDPRVDSTSSDQYQNTRDTVNSSNAIADAPNDYLHASNEAPHKSGILNKLDPRVDSNLSGRESFQGRASGNACNTSDCYVTNDPGKGPQSQGIRPSHQQSQNLDGYLDNNGYAKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P193</accession>
    <name>A0A0B1P193_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative bacterial alpha-l-rhamnosidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P193"/>
    <dbReference type="STRING" id="52586.A0A0B1P193"/>
    <dbReference type="HOGENOM" id="CLU_007933_3_0_1"/>
    <dbReference type="OMA" id="IMYNTQN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079640" evidence="1">
        <location>
            <begin position="18"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="571"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="678" mass="75153" checksum="83EB642903D54A6B" modified="2015-03-04" version="1">MFFYGLFLLFFYRLSLAAKTCWRSTTCAGPETAAFPGDWDQYNFSPERRTITPKNILSKDGEILSSFPGPAELPGNGSQLIFDFGKEVGGILTITYNSTKESTLNLAFSEAKNWIGEWSDDSNGSFNPDGALTTNVTATREATYEMPLGKLRGGFRYLTIFEKSVPDSTIHILNVSLEISYQPDWPNLRAYKGYFSCSDPLLTEIWYSGAYTLQTNAIPPSTGREFPILGADWMNDADLSLGVPGSTVYVDGSKRDRTVWSGDLHVAVPSILVSTGDWDGVKTTLKILYAGQASNGELPFAGPKINIYNSDTYHMITLIASYDFFLWTNDKDWLESIYENKYKKAMDFITNKVDKTGMLFVTDKEDWGRLSQGGYNTQANLLFYKVLVTASQIARWMNDTAQASVWSNLATILQRSVNENNFDSNYGAYKNTNEDGSIYPQDANSLALIYNFSTPDNNARISNSLSRNWINIGSLAPELPNNLVGYGQSLEIKGHLAANQPYRALELIRRAWGWYLKHPNGTASTCIEGYRADGSFGYRATTGYGNHYSYTSHAHGWSTGPTNVLTSYIVGLTLTTPGGQNWAICPQFGDLTFAEAGFSTPLGKFSSKWSLVEGGFQLSWDMPIETTGEIFIPMTSKRVPIIYLNGESCSFKDCKVVIMADKVMVPGSGGSQTLQVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D7</accession>
    <name>A0A0B1P1D7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna methylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003247">
        <property type="protein sequence ID" value="KHJ31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1D7"/>
    <dbReference type="HOGENOM" id="CLU_029646_2_0_1"/>
    <dbReference type="OMA" id="ANILPRH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="309" mass="35090" checksum="CB70C94B6959A57C" modified="2015-03-04" version="1">MKSAEQEFCIFEEWKLQTEKLSDHRKPDMVYLGRYLGGSDRDIVQKLDLKKRNYICTTSMDAELALVTANISLAASGKLFYDPFVGSGSFLVACAHFGATVFGSDIDGRSIRGKGERNLYSNFIQYKLTDFFGDSFVADLTNNPLRQIRVFDSIICDPPYGVREGLKVLGSRDPTKGKEPVVRNGQAHHTLDSYIPPKRPYSFLAMLDNILDFAALSLIENGRLSFWMPTSNDRNQEIKIPQHPCLEISSVCTQSFSKWSRRLITFRRVPDSEFTQLIREPRAIVDGLNADELNPFRKGYFQGFKPNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1L0</accession>
    <name>A0A0B1P1L0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g3265</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="JNVN01003152">
        <property type="protein sequence ID" value="KHJ31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1L0"/>
    <dbReference type="HOGENOM" id="CLU_045153_0_0_1"/>
    <dbReference type="OMA" id="WPGDKFV"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="36875" checksum="117D72F93B78BAB2" modified="2015-03-04" version="1">MESNYNHGNRAFLQAIMGRGSLTLSEGKSIVATILNVQEGTTITEDDVSQATFDSFIAAAAEAVSCFEYEIRSMQHQITKNKIYAFVNSVSDPFTQQATLRSPDELLYIKRLLDTIFETNNSRRKEVMAITSMQALEIQIRKGNSDKGLTQTEAEALLSSLEKENWLERSPKGYYSLAPRALMELRTWLIDNYNDNEDPNANQKIKFCEACREIVTVGQRCIDLDCNTRLHNICEAAFWKSRPSRNCPKCELQWNGENYVGEKAITIEEENLRRKSRGEKRRRQSQSNKVNNANGEEQEQIDNGVRKRRARLELPNTNDASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q6</accession>
    <name>A0A0B1P1Q6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative bromodomain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001970">
        <property type="protein sequence ID" value="KHJ32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q6"/>
    <dbReference type="HOGENOM" id="CLU_012767_0_0_1"/>
    <dbReference type="OMA" id="LWTNAYF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000083">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="689" mass="76205" checksum="12A48139A2941709" modified="2015-03-04" version="1">MSKRISGAGLVAEEFDERAVKRRKLPLDGKDETAEIITQHGLELLDVIKRTSDKNGRLIATDFLTLPNKRLLPEYYQVIKMPIALDTIENKLKRGEIQSLAILEGYFKRMVLNAKEFNARGSLIYEDSERLRKVINNYMMKYNSAHKTTSGLAPLPISLPAEDNKPIDLKSPQRLNSEEPAMKKSIRISRSSQNSKSTTNSILPEPHDNEQSFEGLSFQQAQEKIVDDMISQKEQENDDFGAFEPFINLPSRKEYKDYYSVINYPLALRDLQKAVKGIRSKTPGVSEFKTWAAFEEEAAFIWKNAFQYNEDNSDIFKLALDLQKFFRKSLQKAKSAVTEPASTKIKLRMPEPTKITLKISKKSSPTETIASQSVQSALGSQSFSNGTASRNQINVSMNTLSVSRPDSDESLSKSVLSSTNPILVPVKNEHGSSTSPNLQNSSSSISTSTTPVDIPQPTSVPTSELKSSSMNASTAVPKNAASNVTTETSTASKTVITTASTIAPTTTASTTSTNLSSTIQKNALSYGGYMQTLVNQSPSTMLFNSKFRLPGKTASDAMITNLSIATHPGLNIIRHFHMDLPPSTTLAQQSVTINLPATHYYLQIKPSIALSMMQRQHKLFVTAGTTRLHAMPTIPGHPVEPRNPLFEARLHPGVNRIEIEIIAAFPKGTISTREVEVEKINLYVNLMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1T0</accession>
    <name>A0A0B1P1T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003553">
        <property type="protein sequence ID" value="KHJ30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1T0"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="151" mass="16881" checksum="0600CFEF55AD58FB" modified="2015-03-04" version="1">MQHLQNLMSACFSELTKTTSGVFLLYLVCVKYCIPSDVTHVTRTPTSFVLTIKEKEIRQKLLNDCDRISSQGTKLEPVSDLITYRIATVPIALRTSSGSVTVDDTNLVAEIIRVTYVAPKIVRVHSKIRSGAPHCSWLARFSREQAPRPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H9</accession>
    <name>A0A0B1P2H9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative calcium calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002035">
        <property type="protein sequence ID" value="KHJ32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2H9"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106057">
        <property type="term" value="P:negative regulation of calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="416" mass="46539" checksum="157E9E9BC746FBF5" modified="2015-03-04" version="1">MNTDIAHKQSTKPKIQACQYKTGKTLGSGSYSIVKECVHIKTGRFYAAKVINKRLMTGREHMVRNEIAILKCVSMGHQNVLTLVDFFETPNNLYLITDLAVGGELFDRITRKGSYFEADAVELIRATLSAVSYLHDHGIVHRDLKPENLLFRTPEENADLLIADFGLSRIINEEKYHTLTTTCGTPGYMAPEIFTKTGHGKPVDMWAIGVMTYFLLCGYAPFDRETNLEEMQAILAAEYSFLPIAYWRNVSLDARQFIKSCLIADSTKRITAHEALSHPFITKLRKGDDLLPTVKKNFNARRTIHTAIDTIRAINKLRKLQDNLMNGELSEDPTIGATQLLHSNSDGGAGTDFNQNVQNLTSDSSSDNATRKEAAMWKIPPNDVSGQAPSHLELQSQTNPEISTGLWIPRAPEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2U8</accession>
    <name>A0A0B1P2U8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rna-3-phosphate cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003368">
        <property type="protein sequence ID" value="KHJ30989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2U8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2U8"/>
    <dbReference type="HOGENOM" id="CLU_027882_1_0_1"/>
    <dbReference type="OMA" id="YTDQNKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="206"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="42848" checksum="D7510643DF294BCC" modified="2015-03-04" version="1">MSTPSSDFLRFTGHKSFSHRLVLSTLTGRPIHISHIRSSSTNPGLAPHEISLLRLFDSVTNGSVIQISYTGTSFSYIPGIITGGITTVESDCVNCVLPATCDRGVSWFLLPLCLLGPFSKSPIRVRFKGDGVITSSTENGDISVDTMRTAVLPYYEHFGISTNSLELRVIQRSCAGPGGIGGCGIVELRFECQLRLPKTVHLNHCPGRIKRVRGVAYCTGVSANGNMRMIQAARQLLNPLLCDISIATQYNQAASVTKGDKNIRFGIGFGISLIAETSCRGVIYSADVSTKSEGGVTPEEIGRKCALQLLETISQGGFVTRIGSMTVLTLLTMGSEDIGRVRICREVLASEHVIEMARNFKIFGASNWGLRDIEDDDTGDIIVSIKGMGIGNIGKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V3</accession>
    <name>A0A0B1P2V3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6375</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003365">
        <property type="protein sequence ID" value="KHJ30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2V3"/>
    <dbReference type="HOGENOM" id="CLU_001042_9_0_1"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="680"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133901" checksum="5B4812EFC14D2F1E" modified="2015-03-04" version="1">MRVIEVVIDGFKSYAVRTVISGWDESFNSITGLNGSGKSNILDSICFVLGITNMSTVRAQNLQDLIYKRGQAGVTKASVTIVFDNRDKKKSPIGFEEYPQISVTRQIMLGGTSKYLINGHRAQQQTVQNLFQSVQLNINNPNFLIMQGKITKVLNMKSLEILAMIEEAAGTRMFEDRRDRAFKTMAKKEMKVQEITELLRDEIEPKLEKLRTEKRAFLDFQQTQNDLERLTRLVVAHDYIKSNQKLNQSQSDLEQKKLEMCKLEADSLKLKSEIEYLTEDVKRVRSLREKEVKRGGMAQALEEKLKNFSHELVRLTTVVDLKEASISEERERKAIILRNIAELKSFLEQKTYIYDEIQMQYDRANQELQKQSQEVEVKEELLQTLQTGVASKEGQESGYQGQLQDARNRVSAASTEQEQLKLKITHLETRIEEESPRAIKAKDQNKELLNGLQSLRVEAQTLENQLKTLGFIPGQENDMYKQETELQNEIWELKGQIDSLKRKVINIEFNYDDPTPNFNRHKVKGLVAQLFTLDKKRLDTATALEICAGGRLYNVVVDTETTGTQILQKGKLRKRITIIPLNKITAIKASSEKIDTALQICPGKVDLALSLIGFDEEVSAAMDYVFGNTLICADAATAKRITFDPVIRMKSITLEGDSYDPSGTLSGGSSANSNGVLITLQKLNELNKTLEHKEDSLRVLQATIASEKQKLNQIKKIKQELDLKSHEIKLCGEQIENNSSTSIIQVVENMKLNVSQMKDDLKEARKRQEQANLDIKRIEKDIVDFHSNKDGKLIELQTSLDLLRKSLTSNLRNFKDLQKKLQEARLDLEQAGSDLSTTQDQLHDIEQILLTQDKEIHILDEKKKEIQKKHDNAHALLLEEHAKLTGFDEELNSLEQISRSKSAKIVEGSLEIQKIGHQIEKSCKEIQAAKQAITSMEKEHGWIIDEKGSFGLAGSLYDFNGQNISECKSSLRNLSERFQGMKKKINPKVMNMIDSVEKKEVSLKNMMKTVIRDKKKIEETIITLDEYKKKALLETWTKVNKDFGQIFAELLPGSFAKLDPPEGKTINDGLEFKVSLGNVWKQSLTEFSGGQRSLIALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRTRFSEGTSVVQALTPADFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Y6</accession>
    <name>A0A0B1P2Y6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001917">
        <property type="protein sequence ID" value="KHJ32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Y6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Y6"/>
    <dbReference type="HOGENOM" id="CLU_029060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF2">
        <property type="entry name" value="GUANYL-SPECIFIC RIBONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="47217" checksum="C924F3133F8B5D6F" modified="2015-03-04" version="1">MWPISKKKKVYRDKNTVGSFNVVFTKENEIIDVIARISNNHFTKCIRIDSSQTGLISIPDTTNGYQCSHEFFKDEMLQEALQLALKGIEENLAPYPKPYIGNIFPQESNYKIWPIKNGNDLYKYGKIRSGPFYLVFDTLGNIKGALVKGLHDNYLRCIRKRVAPTAPASDPLSKLFVPAPKPGYMCGRTFFEDENLKEAAEIALRISTQNLKKSIYAKSQFPTKHNGKPFNRPYLLWPIVRFGALYQKGNPGPYRVALELDHKVICAVMVENNIVKQCEKMTLKGNINHDTSDYLCLKQIFYNDHLVRTTEEACRSMKKYLNAYFPAAYRGPGYESEGPYFTYPIKKKGFFRIQPGPHRIVINSNCKFVGALTTIKTGFGSKLVKCHRLETDPEITEMPIVTNEHISEQRILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Y7</accession>
    <name>A0A0B1P2Y7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002657">
        <property type="protein sequence ID" value="KHJ31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Y7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Y7"/>
    <dbReference type="HOGENOM" id="CLU_1134267_0_0_1"/>
    <dbReference type="OMA" id="WSISIVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="283" mass="31537" checksum="74A24A55B40514AF" modified="2015-03-04" version="1">MPPPDYIVTDAGSNFTGKEFHLCATSMAVCVKNIPVEAHWSIGLVERYHALLRRSYEIIYQELKGESLSRDNILQMAVKSINDTAGPNRLIPTLLVFGAFPRMTQLDPPALSIIQRASAIRKAMEEISKLKAKFKVNDALNHRNGPETSQVHELPLNSVVLVWREAKSGKPGKWKGPHTLIGIEDETCLIELPSGPTKFRSTSVRPYYNIAEISKNNDNDNSTNGESNNTGKDESKMSINTNSNDNDNKPQVSGQKTSQTEQQMTAPRRNQPRTRKLPARSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P373</accession>
    <name>A0A0B1P373_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002953">
        <property type="protein sequence ID" value="KHJ31361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P373"/>
    <dbReference type="STRING" id="52586.A0A0B1P373"/>
    <dbReference type="HOGENOM" id="CLU_008776_2_0_1"/>
    <dbReference type="OMA" id="TNVDPGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="331"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="594" mass="66705" checksum="EF627EC4621E0721" modified="2015-03-04" version="1">MLEDSTYKEIVRWTDGGESFVVLENEKFTKTVLPKHFKHSNFASFVRQLNKYDFHKVRLNSDENAPSPYGPNAWEFKHPEFQEHKKDLLDNIKRKTPAPRKPAPATEDHASSQQVDLLNSQLVASQQHIKKLSESYNELAQSQMKLMQHVVQLQRLAWSHEQVMRRVIYCVDSLKDNHRLDYSTGLRNGDTTNGSIINDNVSSSLQEANELLRDFSAKNLPDKELESKKNNLHQRNDCSMLPSDPPVALQPTSHNAGFYNTNELENLVYPVGDTNGINPIHSEHIHNIPYPPPTDILAQSSLPEMASDNSVISNSKNTRSGKSIWGKRKPMILLVEDDKVCARIGTKFLRAFDCGVETASDGLQAVSRINNGPITFDLILMDIIMPHLDGVSATVCIKDLHPHIPIIAMTSNIRADDIHMYFSHGMDDVLPKPFTKEGMLRALEKHLPKQKKAVFQHSNQISHPAEFKNPETSQISLSIDLGQISTSQLKTETLPDEATSSGSPWDPSNQLTLQSPAGNTSGSYLRQTMGGTFDMESSLSTGLITYSPREPSSVILGQHEHKRIAHLEIPSFTDDGPPEKRQRTFPSQAKIYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3E6</accession>
    <name>A0A0B1P3E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor cys6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002868">
        <property type="protein sequence ID" value="KHJ31471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3E6"/>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="OMA" id="IWPLYTL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="550" mass="62913" checksum="D0DEE86284C1319F" modified="2015-03-04" version="1">MGFRGQPSKSCHACRQRKTRCDQLKPGCTQCKRANRECPGYRVEGEIVFKHETSKVEQRCKAKKKNISRNLTSDNDKPSKQEFYVCKSRNQKEFVPFFLPASIPTSCEDRAIGLFISNFVNGKNGPSRGHMEYFEDLARTEALSEGLVAAMKAVGYAVCAHRLNAPSMIQRARHQYVQALQLTNKALQDPVDVKKNSTIVGIIVLGIYETIIGKKSGSHSDWIHHFNGAVALIKMRGPEQLTNPIGLGVFVTVCRNLLIAGIKHAVALPSHLRDYMNIALEIIRKDDLNPSFDIIYCMMQFGDLRVDSFNKTICDKEILRRSIELDNKLEDICLNHPSNWEYRTFKTDKISPLIFKGYYHIYSDLRIAQVWNMFRTLRIMINQMIYDVLNRLIKEYNHPRYICQVTKVSHTLFDLQHDILYSVPQFIGVFSSQNVREISYNERGFRVPMSGTWYLCRPLWLAALLHNSTQEIKDFAVYNLRNISKIGGIREGDSLADSIESSSLPCKKPPDPYYKTKTDARIDISSVEDLIFSEKVHSYDLSQIEGDVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4K0</accession>
    <name>A0A0B1P4K0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002550">
        <property type="protein sequence ID" value="KHJ31826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4K0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4K0"/>
    <dbReference type="HOGENOM" id="CLU_509203_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="62338" checksum="7672892A4B4166F0" modified="2015-03-04" version="1">MMSIHEFIPEDCQGYINGHQCDFRTCPYIHSAARREEVLQQLVRQGKIRRKYVPINDPLPMKLQRNWRHDCEKEFNKGKKFSLVEECKAGYLQKCSSDGHLNYLKELTKSSILEQKNFMSKSKGDILTPPFSKNVQQKHKSNHVQQPHLAAQATNKLIPESRALCSQTSSSKSEISNLKAFSKTSASVQINCEFNEDKQSNLDEFRKLREDLSNWDPERLKWINNLSLEKRNAYLGDLLKNKNNKPKRSNHEAKPMLAAESKSLKNGKFHLFTNLPAEIRNQIWEYAKLNSTSTCHILLDIKQEPGDKISISNGKLKIVPNPILDARFRYLYHVPGMYGACKESRSFVKNLYGNPKMVAFNQSTQQPYPSGKGTCILNFEQDRVFFISCGSFSQLPEFVKFMRREERNQIKHLAIPFRDYFHENITVIRSLVHFPNLQTLDLVLGEDKEDLKRIGNKFDYSDFLRKSLQEQHMIEDGEYLVGEEQENNERKKRRKWSIPRVKTVFVSKTLARAWKIDGFRWETTSKSIPPRLIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U4</accession>
    <name>A0A0B1P4U4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative eukaryotic translation initiation factor 4 gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002650">
        <property type="protein sequence ID" value="KHJ31694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4U4"/>
    <dbReference type="HOGENOM" id="CLU_003998_0_0_1"/>
    <dbReference type="OMA" id="PAHMANF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1004"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="115"/>
            <end position="320"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="396"/>
            <end position="434"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="466"/>
            <end position="516"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="589"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="952"/>
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        <location>
            <begin position="1403"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1434" mass="155346" checksum="11D5B661E8E63189" modified="2015-03-04" version="1">MTPTPQPSQIPSQATSASISTPSYSSAAKKAVSSPTVAAGSSSQSSIVAVGSSGSVQPSHGKSSPVLPINGKHSISPAVPAVSAPVIAYSSSVINGASNHNRKSSVTIVANGRHSMNGGPVGGSSGKIQFGSITDSPASSHITPQIYQHSGTPPGSILNPRVSDPSHSPTPIPQPSASGGRPQVVGPGNGVNFGSFGGDSDRHIRQVSGPQHPQVPGVQHVRHDSTQPGQSDLSNQQGRGAYPHQGGRGRGGFQNQFQQHQMNNFPQMNNSFRNTQNQGRGGIPPFQSQGRPPYSSSPHQPSRSPALPTSLPGTPSMNPSMPIPNQQQYANHFFSPHMAGPQYGYPPQFDARALPLQATGYLYPQITCLSNMAFVSAPPQSPQTAFQQTHYTPGQYAPQAQQMSRNSSQISDHQQTSNLGQPRTPSITSIVLPLTPKPSVSNTVSFTRPTRKNAAIVIKRPDGEAVDVGSFKAPSSPAPNARPRTPPIISSNPTIPPKPSTPIQATHTSGSPGIKTSDQIKQEMKEKVMKAAAEDHLTSAKPINPIKDSEAKIDEEKSNNKINNNETEQSEEVKITTNTAKDLEEEKNDEIERQIAEIEAAELERAKKEAEILKKRDAQRLLEKARQEKLSETTRKEQDRILREKELEMERLEDEKEKIRAQAERKNGRGEQAKSVKDLLNETSKKEEMPSHTAENNQIPKLMTPSVGVETGASSTLDEVMGPPQKINSADKRMNKPVALDLKQSNGKPIEPPQPSAALRSLKSARFLTVLDPMIYPPSISSPNPALNQAVKDKGRSFKYDKEFLLQFQKVFIEKPSMEFESQIKALIGEPETGSTRSGSTRTSENTTSRSNSSRNSTQAGFTTGAFASFGSGKSLTSGSSANQRYSLPALSMARTPINPMVNFIHPRNNGPPAGNPMSRNPSNSGMPHSPRQQSRRGNASNKGFNPSNAKQEAQAAKTMPLTAGLDVRPIQVSATGWKPRSIGNSQSGPVPGASNHMDPDMVQRKVKAALNKMTPEKFDKISDQIFAIAAQSKFEADGRTLRQVIQLTFEKATDEAHWASMYAKFCKRMLETMSSDIKDETILDKNGEVVSGGNLFRKYLLNRCQEEFERGWKIDLPEKPEDERAEEKTEEAALLSDEYYIAAAAKRRGLGLVQFIGELYKLGMLTERIMHQCVMKLVDYKGVPDEAEVESLIKLLKTIGANLEASERGRQVMDAYFDRIKSMIKSESLPSRLRFMLMDIVDLRLAHWASKELNKGPKTLDEVRIEAEAAAAQKAAESARNSQRGGGGGGNRMSMGRGDSRNFSNQYGNQQMSDSQRNIVPIDEIRKLSTKTNNPRSSNQTFAPSTLFSRTNSGRKMGASGAINRLGEDSGISSRSGTPPQMKERESTTSVNAFSLLAVLGSSETENPTSPPSISASPALSKSTPVSTEKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Z7</accession>
    <name>A0A0B1P4Z7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="JNVN01002102">
        <property type="protein sequence ID" value="KHJ32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Z7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Z7"/>
    <dbReference type="HOGENOM" id="CLU_048345_1_0_1"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="34729" checksum="3EEA75232B1D2B61" modified="2015-03-04" version="1">MVDRPKKPTALSTNSPSLQAQVTTSFSDSRISAILPTGESIIVLLHGATIISWKDKSGNEQLWLSEAAKLDGSKPVRGGIPLVFPVFGTDNSHPATSQLPQHGFARTSRWEFLGKSTTEPGDGDSVKLDFGLQTNNLNEETKKLWPFSFGLIYSITLAQNELTTSILVINEGQSAWEFQTLMHTYFRVKDIFSVEIKGLESSSYIDKLSNPITTKTSSSSSVKISSRIDQVYSLLEDKNTPISILENGKKIFNISRDNLSDVVIWNPWSEGAASMTDFAPTEGFKEMICVESGSVKDWIELGPGETWSGSQIISIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P552</accession>
    <name>A0A0B1P552_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative atp-dependent protease la domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002052">
        <property type="protein sequence ID" value="KHJ32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P552"/>
    <dbReference type="STRING" id="52586.A0A0B1P552"/>
    <dbReference type="HOGENOM" id="CLU_013989_3_0_1"/>
    <dbReference type="OMA" id="PWWFASV"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="309"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="63984" checksum="ABCAB9A3BFD7D75B" modified="2015-03-04" version="1">MSSLPLSSTHTLPHRASLRQVSSASAQEINFHDDPPDPFRDVRNILRIAECPQCSNPLQSPTTLPCGNSLCMRCIPKLHVRQNITYSSAPNRLQGFLCSFSSCEIEHAIGDCNKDVTLNKIMNAVRLELGGAKEHQTGNLDVCLKLQERDSRHRSVALQNTGDRSKAHSNGRLFATHSRYDIAKLPHESDFDYSNSSLDIENLNRRNNSILLRLKEAIRSELDCQICYGIFVDPYITTCGHTFCLKCLEKVFEHSKLCPICRSSQTRTTSQKASIAPSRLLAKLIQGLYPENAAMRIFPVQNEEVCNDDMKVPLFICTPSFPSMPTFLHIFEPRYRLMIRRVMETSERKFGMLLHNQSRESQGNLGSVGFYEYGTMLHIVNMHRLPNGHILIETIGVSRFRVVKYGIKDEYTIGKIEPVDDISVSDEEALEARETLQSRSISVKSDATTEESSYNSSQQTYYRPEAMSTQALLEVGVDFVKRMQEQSAPWLQTRVFQAYGKCPQDPDFFPWWFASVLPISDMQKYELLSTESVRDRLKICVRWVKEIEHQSDNNLDSNCGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P597</accession>
    <name>A0A0B1P597_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002570">
        <property type="protein sequence ID" value="KHJ31804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P597"/>
    <dbReference type="STRING" id="52586.A0A0B1P597"/>
    <dbReference type="HOGENOM" id="CLU_021928_3_0_1"/>
    <dbReference type="OMA" id="DHNAWNP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="65147" checksum="B229E145BEE4641E" modified="2015-03-04" version="1">MKPSCKALSKSCSRTYLIQTKGCANARGCLQPYHYATCHRRQLYNTAFKARPMHIRRISAVVLFGAVGYRAWQSYHNQSGFLSSSPVTVNTESQPKVERKASVVDPEPLYTSIIPENEPLSKETDESGTKYLEMMTPEQATSKLRRNEESYLVGRGKGVKRYDIVQIPSNDPIEDDHAEKIVEIPHSRSNASSESSFSDWMFWGVFDGHSGWTTSAKLRQVLINFVARELNTTLQAAVAQNNTDSPSNEAIHNAIKTGFTRLDDEIVIKNVEKTFKANSKIAAAELLAPALSGSCALLSFYDSNSKLLHVACTGDSRAVLGRRGENGKWTAMPLSEDQTGSNPNEQARIQKEHPEEDHVIRNGRVLGGLEPTRAFGDASYKWSREISERLKTSFFGRTPSKLLQTPPYVTAEPVVTSTQVYPEKNDFLVMATDGLWEMLSNEEVVGLVGMWLEKQESKESKSSWASYLLGGQNNGLPVENNAQRIISQDGQKVPIRQMQWGLTEEEQRFTVQDRNAATHLVRNALGGKNSEMLCALLSLPAPYSRRYRDDLTVQVIFFGAGNDNNGKVVINDEATADARNIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A5</accession>
    <name>A0A0B1P5A5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002564">
        <property type="protein sequence ID" value="KHJ31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5A5"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="OMA" id="MEXDEAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="376" mass="43158" checksum="85041CF0377065A6" modified="2015-03-04" version="1">MHADNNLTLAQVKTLLPEEFKDFADVFLQKDADTLPFHRPGKDHEIKLHEGAIPCFKRSYAMSNDELTVVKKYIDDNLAKGFIRPSSSLYAAPVLLVKKPSGGNCMCVDYRALNNITVKNRYPIPLISETLDRLSNAKYFTTLDAISTFNRIRMKPGDEEKSAFNTRYGQFEYLVMPFGLCNAPSSFQSLINDTIHDYLDVFATAYLDDILIYSESLDDHIPHVRKVLQRMRDNNLQLDIHKCNFMTNKVKYLGLTISTNGLCMDHTKVDAITNWKTPSNLKDVRAFIVFANFYRRFINNFSAIVNPLTNMTKFLCIYGKKQKPLFQWNDQCQKSFDNLKMAFTTAPILTHFQHGRETWVETDASDYVTAATYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5E6</accession>
    <name>A0A0B1P5E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001155">
        <property type="protein sequence ID" value="KHJ33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5E6"/>
    <dbReference type="HOGENOM" id="CLU_025841_2_1_1"/>
    <dbReference type="OMA" id="GLMPINS"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="406"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="680" mass="76357" checksum="B1368213A98545A5" modified="2015-03-04" version="1">MEKITDKIAALPHGSNYFSLEFFPPKTIMGVSNLRTRLSRMSQALKPLFVTVTWGTGGSTAANSLELAELCQRELGLTTCLHLTCTNSSPNVIDEALKKAHELGIRNILALRGDPPRKEYMSADLEMEESKKFEWAIDLVKYIKKKYGNYFCVGVAAYPEGHADGNHPDSQSFEHDLPYLVEKVKAGADFIMTQLFFDTDAYDVFERRLREHESGCFEMIPIIPGLMPIQSYQMIKRIAKLTHVKIPPKIAARLDTTIGDDELSKEVGVDIVSEIILHIQQNPLPALGRRGFHLYTLNLEKAVSLIIERTSLIPSTSSTIGDNSEPEYVIVDKPVLTPTEINTLAHSCKGQHQQNLNLLNPNTNTAMKKSSSFFDVASPDIDTLLNSSTISASNLVRTKNIGSLGREATWDDFPNGRWGDVRSPAYGEIDGYGVSLHVSVKQAIHLWGYPQSKDDITSIFVKHVNGSLILIPWSDEGLYRESDVIKDQLLKLNKKGYWTIASQPAINGIRSSDSTFGWGPRNGFVFQKEFVEFFILSKDWESLKIKLQFTSITRNISWFASDSKGNFLSSGTNEELGLKNKEYPGNVNAVTWGVFPGKEIITPTIIEEVSFRTWAEEAFGIWAEWAKVYINGGPYLTDASREAARRSHRLIESVREEIWLVNIIHHGFNEKDSLWNFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J2</accession>
    <name>A0A0B1P5J2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent protein kinase regulator pho80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002252">
        <property type="protein sequence ID" value="KHJ32191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5J2"/>
    <dbReference type="HOGENOM" id="CLU_071095_1_0_1"/>
    <dbReference type="OMA" id="ADIFYWP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058921" description="Cyclin-dependent protein kinase regulator pho80" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22217" checksum="7761037D84DC5E0F" modified="2015-03-04" version="1">MNITGFFATIFFIAYRAQAARKTAVVSLQPVDIHNPGKPTTLATISFDSYTFDAEFSSYETPILSDLISENRSKSDIKYFRVGIYDVVNESWASSTTISSVETFAKGYSPIFIINCNMEGVIESVSVKGHKIDAGMTRDFGPQIHVLKMSKGPRPYLNRPVVLKEGKVEAPVPEKSFLQKYWWLIAAALMVIISAKGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M5</accession>
    <name>A0A0B1P5M5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative duf323 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001352">
        <property type="protein sequence ID" value="KHJ33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5M5"/>
    <dbReference type="HOGENOM" id="CLU_105538_0_0_1"/>
    <dbReference type="OMA" id="AVDMANT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="3">
        <location>
            <begin position="35"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="24025" checksum="4FB42DCCA6C6AF14" modified="2015-03-04" version="1">MSNELLSQKRSTEKKCNRDKRIFDIRSNSVEDYLKEEVLKSLRSTSRPRTLPTMLLYNEQGLQLFEELTYLEEYYLTKAEIDILMESAREIASIITSGSMVVELGSGNLRKVIFLLKEFEKQKKKIDYYALDLCAKELNRTLEQAPPFRYVSCYGLHGTYEDGLLWLGSAINRQRSKVILSLGSSLGTLNSLISMFLELKISRKFQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S6</accession>
    <name>A0A0B1P5S6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001085">
        <property type="protein sequence ID" value="KHJ34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S6"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="29862" checksum="E46A89040AB9ECA8" modified="2015-03-04" version="1">MIFPPIPIPIPNPPPLIASPSPPSNLEIPSKTVDSRQILKPVAPSKRLVTGRPTLNNRDKLEIENAFLPKELVDIIAIRQRRECAWHARLQICTTMISSIDSTLANFKEEVEIEEIVAFKTFLRQAIANFAAADSSSPPLIPSHTRLNKGNGNSNHKDKDKDKNLKKVLVVTPYIVPTPVLNRKKTQEAALPNNPPANNKTWVTVARNGQKKARVVVGEKTKTIPSTKASQRQSPTNKTATSGADKRLFVRVPQEHEWRKLSPAGIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P651</accession>
    <name>A0A0B1P651_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short chain dehydrogenase reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001000">
        <property type="protein sequence ID" value="KHJ34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P651"/>
    <dbReference type="STRING" id="52586.A0A0B1P651"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="GAHFKKQ"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="28193" checksum="5EEA639749C1517D" modified="2015-03-04" version="1">MIPIPEADSLLGLLSLKGKVVVITGASGPRGIGIEAARGCAEMGADIAITYATRAEGAQKNVEELQSKYGVKAKAYKCLVGSYAEVENLVQTVIKDFGKIDGFVANAGQVAKAGILDASVDDWNEVIQTDLNGVFHCAKAVGHHFKERKTGSLVITASMSGHIANFPQEQTAYNVAKAGCIHMARSLANEWRDFARVNSVSPGYIDTGLSDFISQDVLNLWKGMIPMGRTANPKELKGAFVYLLSDASTYTTGSDIVIDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P690</accession>
    <name>A0A0B1P690_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative initiation-specific alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000991">
        <property type="protein sequence ID" value="KHJ34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P690"/>
    <dbReference type="STRING" id="52586.A0A0B1P690"/>
    <dbReference type="HOGENOM" id="CLU_022381_5_1_1"/>
    <dbReference type="OMA" id="WIPENVS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="41338" checksum="FF39A4860022E64A" modified="2015-03-04" version="1">MLTFRRALLGATIFIITIYIIKFSHKPIYAASVDKSQHPLTDAPSSDGHVFVSEKSSQHPLIDLSHSSLREKLSYQYPYELEIRFPAYIWQTWKFTPASGEFKESYRPAEASWTELHPSFIHELITDQVAVHLIRHLYASIPEILDAYVSLPLPVLKADFFRYLILFARGGIYADIDTHVLKSAIDWLPETVPREAIGLIIGIGSDAGGGDWDTKHSRRLLFCQWTIQSKPGHPVLREIIARITENTLEKARNGSLSKFDVQEIPEFTGSVIWTDVIFSFFNDERYFNMTTSTGNITWKDFTGIKSAKKLGDVAVLPITSFSPGINQVGIDGYDDSLAFVRHEFAATWKPEQIQPKDAMKQGDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P698</accession>
    <name>A0A0B1P698_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001783">
        <property type="protein sequence ID" value="KHJ32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P698"/>
    <dbReference type="STRING" id="52586.A0A0B1P698"/>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="OMA" id="SYEGWSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000255">
        <property type="entry name" value="Alpha/beta hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="298" mass="33197" checksum="B7022CCFB01BB3B9" modified="2015-03-04" version="1">MITEVEGRQTINDVTLFTKAWKTSSSPVAKLIFIHGFDDHVDRYYELFPTLASQGIEVCGFDQRGWGHSVQKVSDRGLTGPTETVIGDIVSFISTHLPSPVPIFIMGHSMGGAEALVLACNPKYTDVVGQIRGWILESPLIALAKGSEPSFITKFLGRLVARILPWKQIPTGIPREDLSRDPEVVHSLKNDPFLYGVGTLEGLAGMLERADDLSNGRLKLNKEVQSIWIGHGTCDKATSLEASKKWFDEHCIDVEDKELKIYEGGYHQLHADLQKDRLSFDNDVATWILGRVKREVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G9</accession>
    <name>A0A0B1P6G9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative myb dna-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001202">
        <property type="protein sequence ID" value="KHJ33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G9"/>
    <dbReference type="HOGENOM" id="CLU_033832_1_0_1"/>
    <dbReference type="OMA" id="STHIYES"/>
    <dbReference type="OrthoDB" id="2350934at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF24">
        <property type="entry name" value="MYB DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="35316" checksum="2F6486A79B272DD2" modified="2015-03-04" version="1">MGLKRSMSAHQAEYPAKKQSKWSPEEDSLIIELRGRQMKWEDISKRLPGRSAISCRLHYQNYLERRSEWDEERKNKLARIYERFKPEMWAKVAEELAVPWRAVEAMHWQLGEADMAQRAGVIPFSLSSGSTDIVSNTQSQHSPPSRRRSLSQNQALPKTLNADLRISNQYLSPPSTHIYESARTNSLSPQSINKSQKASSKYASSTSSCTTVRRESTPRSVPPTSPSEGVAFAAISSSKRGVGQQVLPSVAEMTTGVSPYLTSAYATSEGGEYSSIGPLSLSTGIINSPHTIQHYQQWPEFYQRRASSGGFQETKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H4</accession>
    <name>A0A0B1P6H4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helix-turn-helix-domain containing protein type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001704">
        <property type="protein sequence ID" value="KHJ32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6H4"/>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OMA" id="AYQVQSC"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18640" checksum="876F7C833F4B5FAF" modified="2015-03-04" version="1">MPSLYEISIPVFTKKLKSLSKIMEKGAAHEAVSNDQLVNTRLIADMENFTFQIQKVTDAARFVAERLGKITPIEYENNEKTYEELQERVKKTIEILESVKESDFGSEEDDLSFTVKGYFLKHTGKSFILEWITPNFYFHLVTAYALLRKEGVNIGKRDFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H8</accession>
    <name>A0A0B1P6H8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001702">
        <property type="protein sequence ID" value="KHJ32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H8"/>
    <dbReference type="HOGENOM" id="CLU_412884_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="665" mass="76022" checksum="7E116C2A5D6C2CBF" modified="2015-03-04" version="1">MDIQSKHRCIKQTENLSTQKRLLNMSPGSTKVSPRRVLITTPKTGSSIADRGHTPSSIPRMKSTPSFISSRRSSSKALRNSNKPFKDCGRKISCKISNSNDEGNNSQPIFTKNRTSTNPTRPKSSPIQNHKQIQALTNSNTSICTPRLNPRKLRKPINLDIFRPRSQQKIPIRRCNVKNRDISSTSYCKDRSEFPDWEFIDWPWVTPYAPIDQLTLLSDIKHFNIFLGPRPKIFTPLRPWVPTFPPHTFRSTINVTQKIQDVPVQGPALHDYKNGLDQYSTPTVNQALPNDDSFGTRHNLYLKNPASLRFLLPNDKTASKNAMWDPAVILLGPSHTLQNENHVKTTDHLEGSSSNHACGEHCSKALKQCTKEIINCVSKMRRQDEILLQEVLQAFLDSKNNSSSHNEYRNDSDEKTKTKWRRSSKRSLNPDVPDFHPKTNNTSDGYTEIERSPLLQTTNVNRLPLKEAPSHRQFKESMGILTPQVKPQLLSTKNKSNRNEIKSSLYPYHEKASSDRENDIEEMLMETCLKKIQALESEAQYYSGGANGMLHNYQFSPKNLSFSTGSISDLLNDIEVDDDHVPGRVANAMEQNWAAQMLEKFRSKYPMTGTVKSGPVMDMKKKLFCDQQQRLEYLLLQRKENNIYRKQIYNMVPSEATSWDKCYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K6</accession>
    <name>A0A0B1P6K6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000957">
        <property type="protein sequence ID" value="KHJ34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K6"/>
    <dbReference type="HOGENOM" id="CLU_011220_0_1_1"/>
    <dbReference type="OMA" id="QGLYQTK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="177"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="48031" checksum="2DB1685ABB5E2B55" modified="2015-03-04" version="1">MQRTLHRELQLTNGTMLCIAKHVVTSSMSRLLQNETLRLERTLSCARINFIGETVWHQRFYSDSTTHQETPNPVESGKKTSPTSKRKLVRSPARKSSLRRVAVEAQRSREGTKLKSKDAILESNENSRVIATSVADQFDMEAVVRILRSHGFQIDPDATDFDTEQVVHTRGVNNGDIFVFPSGSLVAWSLPEDVVSDLATKTLLPATVNPHMDQMEMEDLEYIEDPKRENSSIKADVITLGTKPTSYSVEIANDRIDATLAKIAFSSGLARSTKLAVLETMLLKYFESTRIIPKLLSKNSRLPFNRRFMLQKTGELLELRAQLNHYSELTDSLPDLFWDSRHELGLEGYYDQVGRSLDVGIRIKTLNEKMDYAQEIASIMRHTLSEKHSSHLEWIIIILITVEVGFELRREWKEKKEQQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N1</accession>
    <name>A0A0B1P6N1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000936">
        <property type="protein sequence ID" value="KHJ34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N1"/>
    <dbReference type="HOGENOM" id="CLU_001265_51_3_1"/>
    <dbReference type="OMA" id="FGWCVDR"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="472" mass="51224" checksum="3FC4CC254EC1637B" modified="2015-03-04" version="1">MSSTSKLPPRGLQWRCSTSYILVSASIAMFTDLFLYGLIVPTLPFILSSRLHMPHDDIQQSVSLLLAYYAGASVVASLPAGYIADLLPSRQLPFLTGLVAMFISTALLWLGQNWTILAMARIFQGISASVVWTIGLTMILDAVGSRNLGVVLSSIFGFICVGELLAPVLGGLVYQQLGEAWVFNVGFMMLAIDFFVRILVVEKKVVKRNGWDKMLSHKDSFPTNETDPLICKKNTNASSKTALSKWELPSDVPKWFSKLPVVYLTATSPRILASLLLCFTHSMTLGIFDATIPLESVDLFSFTSRSAGFLFIPLILPYLLLAPVAGLVVDRYGTKIPAAIGLLILACPLTLFGFVNAASPGQEGHFLEVTKFSILLSICGVGIASISSQSLIDESIVIDSYEKANPNLFPGGAPYAQLYAMNNIVFSLGLTLGPLIAGSIRMNFGYPIMNYCLAGWCVLASILCTLFLGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6R2</accession>
    <name>A0A0B1P6R2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative snare domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001133">
        <property type="protein sequence ID" value="KHJ33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6R2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6R2"/>
    <dbReference type="HOGENOM" id="CLU_042423_0_0_1"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="36273" checksum="BFD1F7DDFC39081C" modified="2015-03-04" version="1">MSSNRFSSYAGNSYENSSAVESGVVDNNQAPSYEFSELPANHNSNSHPQALQPSTTLSQSDFLARVDLVKSDIRSLTSSIQEISTLHQRALSSPDSSSSGQLEDLVTRTQLKNSQIRDQIKFLEGDAAKTQDGSKSVKSKQANQLKSEFGKVLNNYRQEELTYQKRYREQIARQYRIVNPEASEAEVNEATNLDWRSEGVFQTVLKGNRSGHATTVLGAVRARHNELQRIEATLTDLAAIFADLAQIVETQDPIIENVEQNAMQTTDHVENANHQIDEAKKSAARARKLKWYCLLVGILIVLAIALGIGLGVGLTKASAKTANNVVNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T2</accession>
    <name>A0A0B1P6T2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative primase zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002143">
        <property type="protein sequence ID" value="KHJ32354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T2"/>
    <dbReference type="HOGENOM" id="CLU_011047_0_0_1"/>
    <dbReference type="OMA" id="IGFCKAV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="366"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="509"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="808" mass="91334" checksum="B2BC417C88EC2AF0" modified="2015-03-04" version="1">MTKYPSDNDNSPETSNWPPKSPHEVLLSTPSGRKRLRLLAEPGSPSPSLSKRLKNSVKLGCQQEPTVINHFDNDDDDDDEETLQLQLQEIQARLKLKKLQKRKKGLDFNVDNRGAKPESGLCKRETATESLNFSENKFYDSNAKTFINVPVSPVLKKLPPIAQKSPSRVLLGIDKGLRGSDVSLRRVPSHRAEKNEWTNGNLGPFFQGSGSYATTKNREKNSGIPETSDKPISFNERLAAVRRESKNDQLRQIQREKSKSSAFDIDQNQLRDLKNHAVEFTDCGGEALEFNRDEVLSSFNTTREVMPREKTNSDFQLLTGLKSYSDEMTRNNLKTATSMKLDEISGSASKQSSEKPDQEALKFEPYSSQHLLKRIIPHKSLTRLLSGKKIFLIPDLLREIKAPDFSSTDFEQDLVVLAVIASKSEPKSHRTGLEKQKRGKFMAFTLTDLKWELEFYLFDSAFEKFWKMTPGTIIAILNPLILPPPRDKIDTGKFSLMLNSNADTILEIGTARDLGFCKSVKRDGKICNSWVNKRHTEFCEYHVSARLNKTHASRMEVNTMTFGKGRYNGKSQGNKNFHSINSKSRGINVSSNIENNTFYDQFNHSRVFLSQKRNTARLLDDVDFDPDGFHRGSTKEERMTKRILSKEKEKKLEKKLAEMGTGLGAEYARVRQTNSNNSSIIRSKTIANITTTNGNHNNNSCDGIHNYLSSLLSFDKNIKKDVALSPAKRKKTDTFSTTTLARGWGKGLTDDLQRMKNGENLNKNTTKSSCVVKKTRFMTENGVREAGRESLGDKVQFDESDDDLDIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6V3</accession>
    <name>A0A0B1P6V3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001115">
        <property type="protein sequence ID" value="KHJ33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6V3"/>
    <dbReference type="HOGENOM" id="CLU_1262348_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="25368" checksum="D573DD49733D6976" modified="2015-03-04" version="1">MELKKAPLKKPEDFFQAIDILLEDKAANWLDTSPRWRRVVDDKKNATERDVIDFKKPICIYFKSNQEQTDPNIHSDLRNLAQGPNEPLEKYYQRSLDILSRSHCRDEPLVESGDECLKPLEAVFLSGVITAFIEGIHDSELRSNVLFKANNSYHSLHGAYEAIKGTQNSMIKFRVIETRLAEKNELEQFREMYSQGRPVWLLLQGLVNNIMESLKDNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P791</accession>
    <name>A0A0B1P791_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001830">
        <property type="protein sequence ID" value="KHJ32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P791"/>
    <dbReference type="STRING" id="52586.A0A0B1P791"/>
    <dbReference type="HOGENOM" id="CLU_066767_2_1_1"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="22853" checksum="07FCABC43FF1B870" modified="2015-03-04" version="1">MSATSRPSNTIKTFGDSTREIPHHSQKAQKWYPVVDDAKPKKVRKTIRTSKIRPSLTPGTILILLAGRFRGKRVILLKNLPQGVLLVTGPFKVNGVPLRRVNARYVIATSYKIDLTGTDESKINEIATEKYFARDKSEKKNGEESFFKGGEKPEKKLPSSSRAADQKAVDKAILANIKKVPFLTSYLASTFSLRKGDRPHEMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M3</accession>
    <name>A0A0B1P7M3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cut9 interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000979">
        <property type="protein sequence ID" value="KHJ34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7M3"/>
    <dbReference type="HOGENOM" id="CLU_031506_3_0_1"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="39846" checksum="4B68EFED2DA19EAC" modified="2015-03-04" version="1">MKARCLTVMATREQDQRLVFQLATSFGVNCPADLGDETPTRRVIPSFGWHPWFSHVIYDDTNLQSMNPSQEKDFKINHYKSILIPIPEDIKFIESLPNPRSLKNFLEEIKNYLKIFPTALIGEIGLDKNFRIPIQWNDNKNIIINNINITPGTRNGRQLSKYRVNMNHQKIIFRAQLQLAGEMNRSVSIHSVQAHGAVFDTLQDLWKEYKIQNSTHKKTSIIQSKNLEIETIDTKLSRPFPRRICLHAYSGSIDLLKQYLDPKVPAIIYFSFCALLNLPTDKVTEVIKAVPEDRILVESDFDKVTDDMDQLLEKMCRRICNDKNWPLEKGVEILGNNWRQFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R4</accession>
    <name>A0A0B1P7R4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endo-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000728">
        <property type="protein sequence ID" value="KHJ34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7R4"/>
    <dbReference type="HOGENOM" id="CLU_016972_4_1_1"/>
    <dbReference type="OMA" id="NSHAINI"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058958" evidence="2">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="55649" checksum="0910DFDC827E7198" modified="2015-03-04" version="1">MLLFQLTTFWISLFAFLVQTSYVLSPDDVYQGNAFFEKFNFFTAADPNAGFVQYLDQNTATNSRLTSVNDAQQVYIGVDYENVYDVNGGRGRPSIRLETKKSYQYGLFVFDLAHMPANTCGKWSAFWTTNEQEWPRWGEIDIIENIHENNNTLEALHTTPGCSVAGNQISTQMTGKQTTYNCDGTATSSQYGTQGSGQGCVAENMSPNNYGKAFNDVGGGIYVMEWNSHAINIWNFNRENIPQDLSSGNPNPDGWEAPVFTTKQGSCIIDDHFKDQRVIIDSAFCGNWAGQDAFWQQTSCYKSDPARYPTCNSYVAANPAAYKESYWLVNSLKVYQQQSSSPANSPTLGAIAPTSSARGSSLPMSPAPGSPAPRSSAPVSPAPEPNDSKPTASQGPESDSESPSPEYSSSDIVSEMPITSIAPIAPVGTASLSVMPYPNANATIPSYRPTATGSLYTTVASAFPTQTLIPVGRIPNNNDESTKPAPKFETAGSSKSAKVSGSSAVALIAALALGMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7W1</accession>
    <name>A0A0B1P7W1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01000945">
        <property type="protein sequence ID" value="KHJ34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7W1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7W1"/>
    <dbReference type="HOGENOM" id="CLU_031816_1_0_1"/>
    <dbReference type="OMA" id="WGVLACQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="436" mass="49307" checksum="A35D80882903ABF7" modified="2015-03-04" version="1">MTTRYRVEYALKSHRRDQFIEWIKGLLAVPFVLYSQPTGVFETRNYSVQKMAEEAHRRYVEIMKDVEEMIDDHIEHQKVGLEGQSKLKLLVPSIGIIFTRLPLADAFRYQDRKRFISSRRFVPPSFNDVRLILNTAQLMGVTTYGKLELATFDGDVTLYDDGKALEPTNPVIERIVYLLSRGTKVGIVTAAGYTEAERYYHRLHGLLEAVKSSSVLNPEQKQSLIIMGGESNYLLRYSSESPFLLTHLPRRSWILSDMSMWTQSSITALLDLAESSFRECVANLSLEATILRKERAVGIIPSVPNYKFPRESLEETALVVQKKLEMSDVGKVLPFCAFNGGNDVFVDIGDKSWGVLVCQNFFGMVNNTPPNDQKNDDCIREKIEARSTLHVGDQFLSAGSNDFRARAVATTAWIASPAETIELLDELKDLMISSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P878</accession>
    <name>A0A0B1P878_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000630">
        <property type="protein sequence ID" value="KHJ34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P878"/>
    <dbReference type="STRING" id="52586.A0A0B1P878"/>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="142"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="438" mass="48855" checksum="2A995C198FBAA82B" modified="2015-03-04" version="1">MPVKSRFTRLDAFTKTVDEARIRTTSGGIVTIVSLLVIFWLAWGEWSDFRRVLVQPELIVDKGRGEKMEIHLNITFPKIPCELLTLDVMDVSGEQQTGIMHGINKVRLSSVADGGYVIDIKSLDLHRDDQATHLDPNYCGPCYGAEAPPNAKKPGCCSTCDEVREAYATNSWAFGRGDSVEQCEREHYAERLDEQRNEGCRIEGAIRVNKVVGNFHIAPGRSFSNGNVHVHDLNNYFDTPVLGGHVFTHIIHSLRFGPQLPTTALMKLSKQNTLWTNHHINPLDNTQQSTDEPAYNFMYFIKVVSTSYLPLGWEKKDYEHHGLDESASLGVYGHKDDGSLETHQYSVTSHHRSLGGGDDSASGHKEKIHARGGIPGVFFSYDISPMKIVNREERSKSFTGFLSGLCAIVGGTLTVAAAIDRGLYEGSTRLKKFRYKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A7</accession>
    <name>A0A0B1P8A7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="4">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001764">
        <property type="protein sequence ID" value="KHJ32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8A7"/>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="165" mass="18221" checksum="7B2F7B3FAA7A0814" modified="2015-03-04" version="1">MATRLVMRSSRLRPMLRLLSYQSRNFTVLPRAQAKKYTKDHEWINLSEDGKTGLIGISKYASDALGEVVYVELPEVPMSVTAGDSIGAVESVKSASDINSPVTCTITSVNKLLEERPKTINEGPEEESSAGGWVAKVEIGESGLQDLQDLMDPQEYKEFTEKDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Q5</accession>
    <name>A0A0B1P8Q5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000533">
        <property type="protein sequence ID" value="KHJ35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Q5"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="229" mass="25333" checksum="ADC14E3A5BFB968B" modified="2015-03-04" version="1">MTIKPVRTGFALSPYSSEAQEALLQTSSRLLNTGAKIEPASNWIPLLVPTVPKYISTLEGQIEVNKEMLANEIERVTSIRPTSVRLYGSSNQAAPHRTWMAFFTKAPRSGFRVFDESGKVTFFKKQKAIDFCKRCNGYHPSRNCSRALSCGNCGSVMHTENDCKALTKCKNCGGPHRSDSHKCLARPTRSGGPTKEQLKTFRTVGEREYQAVARAKAAEQKALASEDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8V4</accession>
    <name>A0A0B1P8V4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001486">
        <property type="protein sequence ID" value="KHJ33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8V4"/>
    <dbReference type="HOGENOM" id="CLU_2833067_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="66" mass="7900" checksum="1579ABA147F4D51B" modified="2015-03-04" version="1">MMNSPEDVARITQWILHEGWIKQFRLVRSRGSTGKKENFKSRERLVWIKHWTHSVNALPKGRIETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8W5</accession>
    <name>A0A0B1P8W5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P8W5"/>
    <dbReference type="HOGENOM" id="CLU_001832_1_1_1"/>
    <dbReference type="OMA" id="MCKLVCR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="488"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="753"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1346" mass="152519" checksum="1F8A49BA3F52AC61" modified="2015-03-04" version="1">MSLGILLVRCIKPRLGVNTIFATSNFRSLRFSSSKSFRKPFQQRQTKKRSSVKPSPKREIPLNLARVQQEPIAYIPKLNDYPDLKKWMFTQPWDAESWNKATNLGSVSRGISRLKQNGAELWKFSFQWLSRSGESFTVACVGSSKLLARKDAAFRLLAALHEKGILNDISREIVEYKDKKSASQIEEKETITLGSQMRTDVYNYGASILAIPQVEIIAKKSRSRTRSKPSGYTVTLKLEERNIEIEESGASLVKTELKVYSKFRKLIEEYHEKENIPNTSLTKETSSLDNSRGKEFIFYYKRKVSKTNMKGESSDQVFFSIKHEQKGSLISAQVCMDGEIIGAPVFARKSKEAEELAYLTAAIYLAKKQPLIWKMFLNEQRSSNGEIIQQFIQVPLQTNRAILKQISETASPIINVRFNQNASLDVTRNSDSIRPRRPFRSNLSFEEERSRNEVLKAQFESYNLNPQFQKLRELKNSLPMNKYKSEVLKLVNENTFCVIVGETGSGKTTQVPAIIFEEAIVKGKGASVNIMCTQPRRIAAKSVAIRVAYERGEKLQDTVGYHVYLDVKRPSNKGSICYCTTEILLKQLQNNPDEAMDTISHIIVDEAHERDIPIDFLFITLKKVIQARRAMKKSVPKVIIMSATLNISLFANYFGELMADGTTIPCPSLTVPGKTYPVRRVYLNDLLKELYQNYGNKTGLQNCSVTQRYLEIERSINDSPNTQSIQNKFGDRISWRANDTDEALIPHTLVAATVAHVVRSSLEGAILVFLPGLKDLEDVQKSLLRKPLDVDFSDNNKYKVVLLHSLMKDAQNSLFEPTPGCRKIILATNIAETSITIPDVRHVIDTGKLNEMNFDPVTRIKNLKCTWASKSNSRQRSGRAGRVQNGFYYALFTEDRFNSFRDCGLPQLLRSDLQDVCLSAKGQTLQYSIQEFLADAIEKPSSQAVDAAIKDLIQLGALTRDEEITPLGRLLHSLPVDPDLGKMVVLGVIFRCLDPLLTLAAAESEKDFFMRPISARKEADQARFSFGRNTFSDAITTIKAFRHARHARRTMNRHDYMSVMIQKFLNAGTVETIEKKMFQIEEVLVSSGVIPRAIQSPNSTSFYCGHYMLNENSDNQSLIKALTLARCPGNLAVRIGTSSRFRTKTESGIQIRTGLNGTRFGQKSLLPRTALISYASIYKDDASKLCLRDTNLVNPIAAALFGGTLESRFRKLVTDDWIIYSTPGEQEDYGCSPYNNILGLRTALNKILSNSFLDLAKRQNLLDDRMRRNFTSAIAQILSDSDNLLRVEEQHTEDTNDSKARIERSDRSTSPQRSLRHKTLQPFVRDLLTEIEYRKTRTNAVRQRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P911</accession>
    <name>A0A0B1P911_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g1497</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="JNVN01000728">
        <property type="protein sequence ID" value="KHJ34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P911"/>
    <dbReference type="STRING" id="52586.A0A0B1P911"/>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="181"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="371" mass="41006" checksum="FBB2CAB0B6B8FFDA" modified="2015-03-04" version="1">MSRITLHLRSEVGKSLERRSALTPTTTRSLIEAGFIINVERSPQRIFDDSEFEEAGATLVPESTWHEAPNDHIIIGLKELPVDDFPLKHTHIQFAHCYKQQRDWDKVLSRFARGGGTLLDLEFLTDDNGRRVAAFGYHAGLAGAALALKVWSWQLLHLPTEPFPSVSCYPNEKELILDVKKAISDGIKKSGSEPKVMIIGALGRCGSGAVSLCEQVGVPDENLLKWDIAETARGGPFREVLQSDIFVNCIYLSSKIPNFIDKPSLNNPERKLSVVCDVSADTTNPYNPIPIYTEATTFTNPTVPVEVDAEPPLSVISIDHLPSLVPREASEAFSRDLLPSLLLLKSRSISSVWARAENLFREKVATLPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C0</accession>
    <name>A0A0B1P9C0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative zinc finger protein ozf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000677">
        <property type="protein sequence ID" value="KHJ34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9C0"/>
    <dbReference type="HOGENOM" id="CLU_028814_0_2_1"/>
    <dbReference type="OMA" id="NVRAHRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="522" mass="57888" checksum="EC56D47DA5DA2F87" modified="2015-03-04" version="1">MAVTVQTPSQAWGRWSEQPHQTLDSYSMNYTVDISGIIQNCDSRSPATTSTGAGPSRALMAPHYVPLPTYSAAPITTVVSHHNHVPPLPPPLPQQQQQQQQQQHLHLQNPFAFNHYQLPNNNNVVSQFTNSYLQSRPTLSYSITHDSSLVRGMPFCRPQRQGFIIETQHNQNQGQNIKNESAWHPSPELSITTPVSQRSSCSPVTKKAASEASFGTEVDTLMKAIQSKPSNQSQAATHVPKRESVDEAGRSKSKKRYQCTIEGCTKSFFQKTHLDIHERAHTGVKPYSCKQPGCNRTFSQLGNLKTHERRHTGERPYQCETCGKRFAQRGNVRAHRIVHDQAKPYVCILDDCGKQFTQLGNLKSHQNKFHISTLRTLTERWASVQDGDSVPAADKELWEYFAKLYKNSNKGIKGRGKDRKVGPSHVMASMRGVGINRAEGFGICGPGRGNMVVNLNLNVAAHPLGRSNANATYNSFDDETSNSGSGSSGDGSVGTCYDEAPSDGFEEQNRTTHISYGDQMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F3</accession>
    <name>A0A0B1P9F3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="JNVN01001115">
        <property type="protein sequence ID" value="KHJ33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9F3"/>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OMA" id="IRHFGVK"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046083">
        <property type="term" value="P:adenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="566" mass="61711" checksum="32AAAC665DA47776" modified="2015-03-04" version="1">MCGILGLILGDVENPSAIITAVDLHDALYYLQHRGQDACGIATCASGGRIYQCKGNGMAAKVFNDGSRVQNLPGFMGLGHLRYPTAGSSASAEAQPFYVNSPYGISFAHNGNLINADELRLYLDREAHRHINTDSDSELMLNILANELNVTGKARVNEEDIFRSLERMYDRCVGAWACTAMLAGFGILGFRDPYGIRPLVMGSRPSSTLDGVVDYMMASESVALQQLGFENIVDIQPGQAVIIRKGNRPLLRQVVPQLAYSPDIFEFVYFARPDAVIDGISVHKSRVNMGIKLANTIVKTLGEELVKEIDVIIPIPETSNTSAASLAERLQKPYCQGFVKNRYVFRTFIMPSQGSRTKAVRRKLSAIPSEFAGRTVLLVDDSIVRGTTSREIICMAREAGAKKVILASSSPPVTHAHIYGVNLASPLELVAHTRDRKAIAEHIGAEDVIYQSLEDLIAACAELSPRGPNQNFEVGVFCGNYVTPTNAKYFEQLQCLRGESSCFQVSELNSGSHVDKRTATNGIKTQKLLADDADSLGCDANSGQNLVQVKEKATSCSPLRDRDDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9G7</accession>
    <name>A0A0B1P9G7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9G7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9G7"/>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="147"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="550" mass="60382" checksum="432D2E52F1656AF1" modified="2015-03-04" version="1">MNNLDRSPSSSSEEDQGLLSRKSSQDHEQIAYLPHHENESLTLPLSQTLQSPRSPLTSLSPQTSRSPSRVRFDLSPIENGVNTVCASPPPPYNNDPSESGHDGENDSHSQNIPLLHSINESYPPSQDAPWGNEDVLTWAEREQQRPKSGMRSAFMNMTNSILGAGIIGQPYAFRQAGLLSGIILLIMLTVMVDWTIGLIVINSKLSGSTSLQGTMKHCFGRTGLIIISLGQWAFAFGGMVAFGIIVGDTIPHVFLALWPGIVNVSVLNFLISRRVVITVFVSLISYPLSLYRDISKLSKASTLAFISMMIILIAVVSQAPIVPAESRGTLDDSFFMVKGGFFQAISVISFALVCQHNSLLIYDSLKTPTLDRFARVTHYSTGVSMLACLLMALSGYITFGSLTQGNVLNNFPPDNILINLARLCFGLNMLTTLPLEAFVCREVMLNYWLAGEPFNIFIHISFTTFLVFSAMMFSLITCDLGVVFELIGAISACGLAYILPPLCYLKLSTRSWKTIPALACIIFGFLTMIISLSQTFIKLLRHENKSVSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N6</accession>
    <name>A0A0B1P9N6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9N6"/>
    <dbReference type="HOGENOM" id="CLU_1788259_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="145" mass="16508" checksum="E80F919DF0459C7B" modified="2015-03-04" version="1">MGTCTMIFPSIFAIIHFIDVPTFPSIDTWPLAVVALLLPLSTLWTTMEPNPTFDILKAWSNQSSEELFTNNGHESLSCKNFSQNLKFGFGKNKTNKYNIEEINSINYTKTAAKKHSSISRDSSKGYLWKSDERLDRRNGSHNEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9R7</accession>
    <name>A0A0B1P9R7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001464">
        <property type="protein sequence ID" value="KHJ33389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9R7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9R7"/>
    <dbReference type="HOGENOM" id="CLU_013725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="476"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="720" mass="79759" checksum="E58ADAAABEA35F5A" modified="2015-03-04" version="1">MGHIANLILDSSADVVSSVYLPPASPTTNKITAFSQTTDLTGANGLEFMTETYVWRMHQSNKNKHPIKKQNSSNELQVNLNEEQKSEETVSISSLPSSFHSKLLSLDKERPASTLSSVLRMKIKEPITNRRRKISVPEIGPMTTVQELAMDSPTIPGRPPIHERSQSVPVSTNRKKLGENAISFLSGPVPDEKAEIMEQKTSNDENQEETLQNTTDSMPVKPILDSSAASQPPISVPVIHTEQGSLVQQPSRFPLLKPKIPKVNINTDSQPPEVPPKQPKALQESQSSAPKSLPFIPISSWSSAFSATFSVSTPTTSPLSEGRFSPKPWSFGRSSPKTWSIPSRSSPKSSPTSSTSSLKLHSQKSETSLLSEAGKLGSNRGHVRHSSEDISELKSDDRGSYEQRSNVNVASKENQPTNQTSDSPLESTSNSTNHDRNSDLTDSSCSLPESQCFLSLPSGHPPSSVSQNLSPTELSHLQNQALSQAFRFEVLSSRDVASLSKELRALDERCEFLRKTHHSLRNDRQSLHARLCSNLRNQRVGRFSCEVLLKLEVNLSELDRCIDACVSKFELAENRRMRLRQKLLEHVAAAAVVEIQNPADSKMQSKKRMHQDTSGENTPPRSPQHEPQRTELEIKGLPSHLDPIPSPIPEPLLLLTPRTHESSPESPTEISKEPLEQIIIIRDTKSDILVQSPQDAYDYADKDVFALMDCVEEEMERMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9V3</accession>
    <name>A0A0B1P9V3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ulp1 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9V3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9V3"/>
    <dbReference type="HOGENOM" id="CLU_038721_0_0_1"/>
    <dbReference type="OMA" id="CANQTNG"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="297"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="59448" checksum="9C94D0CFA8BD44D6" modified="2015-03-04" version="1">MRGRKRRSEYQLTRAGESQCQDLQSDLTMTTIYEVGSTLWNWCISFIFSGISTATSDPVIPVATTANSKESKPTPKTSYEIPHKRPKIFYDANLSKSKSMVDFRSKEVSETLDVSKCDVNEARRKIENFWEPKPLPWVEQSLIAEQQSSTITAIPDSERLLKNQPFTRRSSDPPKLARTPNTHLRRLTLVSKFKFDTKSLEDSCENSIQTSIENLLVGSTKQLAISDFKRAKNLLRAKELKEKERQNAINKLKQRRLLRIYPRQKLVQFLDPYWEDRVCRAHTTWGEDTLSTSIGGTELRIKDFKTLLDHRAWLNDEIINSYIEWVVDAANRNAREELSKFDIEPNSVPPFIAHNSFFYETLRKRGPKSLDRLMKRKGAPGVSLLEVDSVFVPICNGSHWTLGVVRPVAKTIEYFDSMGGNPSNFIHYMEIWLKHQLGEAYSYDEWTIPRTACANQTNGYDCGVFVCTNAFCVAVGLDTLCYQESDMTRQRKSIAAILLNRGFNGDFAWQVRENGLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA46</accession>
    <name>A0A0B1PA46_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase ucpa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001366">
        <property type="protein sequence ID" value="KHJ33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA46"/>
    <dbReference type="STRING" id="52586.A0A0B1PA46"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="28447" checksum="3BB0EFFC3EBE3627" modified="2015-03-04" version="1">MPNYLLLSKSAAITGGITGIGRAITLEYIRQGCNVAINHLDLPSDLHHKSSLLAEIDAIQKEFDQAGRFIEVAGDISIPNTGKELIEVTVREFGGIDILVSNAGVCQFAQFLDLDHDLFASTLGINLHGAFYTCQAAARQMALQNRGGCIIGISSISALVGGGLQTHYTPTKAGVLSLMQSMAVALGKYKIRCNALLPGTINTQLNKNDLEVTEKREYMESRIPLGRIGEPKDLAGPAVFLACEELSGYVNGSQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA65</accession>
    <name>A0A0B1PA65_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="9" type="ORF">EV44_g2721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001358">
        <property type="protein sequence ID" value="KHJ33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA65"/>
    <dbReference type="STRING" id="52586.A0A0B1PA65"/>
    <dbReference type="HOGENOM" id="CLU_026481_1_3_1"/>
    <dbReference type="OMA" id="MGKCERC"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000132">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="8">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="428" mass="47563" checksum="9C7E28463101D258" modified="2015-03-04" version="1">MAPANCEKCKLTRALVIRSKNFQKLCKRCFIFVFEEEIHNTITTAELFSPGERIAIGASGGKDSTVVASVLKTLNERYHYGLDLILLSIDEGIKGYRDDSLETVKRNAIQYEMPLKIVGYDELYGWTMDQVVEAVGKKGNCTYCGVFRRQALDRGAKMLGITHVVTGHNADDLAETIIMNLLRGDLPRLARSTNIITGDKLSEVRRSKPLKYAYEKEIVLYAHHKKLDYFSTECIYSPEAFRGSARSLIKNLERIRPSAILDIIRSGEDIANLISEELSNNSNCQSQKKTQASDHSYEEDIGGCGGFNKGASGGEMILLEKKLQENEKAVSNGTELFSSLAITISQNNITEKSKVALSSTKKAPRKHFRQTLGTCVKCGYMSSQETCKACNLLEGLNKNRPKIEVQIDIEDQLSPTVRKINSSVLAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA89</accession>
    <name>A0A0B1PA89_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative dna repair protein rad10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001192">
        <property type="protein sequence ID" value="KHJ33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA89"/>
    <dbReference type="STRING" id="52586.A0A0B1PA89"/>
    <dbReference type="HOGENOM" id="CLU_041616_1_1_1"/>
    <dbReference type="OMA" id="SAHKANE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="81"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="44759" checksum="15A092E478793AAB" modified="2015-03-04" version="1">MNDDYDEFGADADFLEALAATDPTPLVKKTSQKQTAPLITQPTPQRLAHPDLVPPQVKSSSGPKVVQPKPQILASRSTTSSILVSPRQKGNPVLTNLRSFVWEYSDIPADYILGATTCALFLSLKYHRLHPEYVYNRIKGLYGKYNLRVLLTLVDIQNHEDVIKELTKTCLVNNVTFILCWSAAEAARYLELYKSYEHSKDSAGIKGIEKKTYAEKMIEFITVPRGINKTDAVSLVSAFGSIKGAINARPEEIAIIGGWGEKKVKRWCSVVNEPFRVRTQAKSNNTENLYIPDQSGPLVSASTIQRLNEQIEVEENTQQSKSFPLKISDQVALPTSNLEVNSSTDADDVVDDAESNDALKNNNNLEVISREDKNFKPKTKLNEELSTGLSAALAKLRRENGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW9</accession>
    <name>A0A0B1PAW9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000418">
        <property type="protein sequence ID" value="KHJ35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAW9"/>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="499" mass="54695" checksum="A265C8153D07D965" modified="2015-03-04" version="1">MTSKSISTALAKAQDFLEFVNASPTPYHVVKSAIDRLTTAGFTEIHERDSWSGVKPGQKYYLTRNGSSIVAFAIGKKWKPGNPVAIVGAHTDSPCLRIKPISKKSGAGFLQVGVETYGGGIWHTWFDRDLSIAGRVICKDGKGNYITKLIKIDKPILRIPTLAIHLDRSPNFEPNKETELFPITGLVAAELNKTRKAENDKIPQCVNENKPFQSLKEIGERHHPCIVELIAEDSGVTAENILDFEMLLYDTQKSCVGGINNELIFSARLDNLGMTYCAIEGLIESVISPSALDDEFCIRLSICFDHEEIGSTSAHGAASNLLPAVLRRLSVISSSHESDNSNISTAYEQMLSTSFLISADMAHSVHPNYAHKYEAEHRPEINKGTVIKINANQRYATNSPGIVLLREVANLAKPAEISSTSQGVPLQLFVVRNDSPCGSTIGPMLSASLGMRTIDLGNPQLSMHSIRETGGVYDVEVATKLFESFFVHYSNLESRILIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB67</accession>
    <name>A0A0B1PB67_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001162">
        <property type="protein sequence ID" value="KHJ33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB67"/>
    <dbReference type="STRING" id="52586.A0A0B1PB67"/>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="18341" checksum="5F7378110778DD5D" modified="2015-03-04" version="1">MAIHYLILLSRQGKVRLAKWFTTLSPKEKAKIIKDVSQLVLARRTRMCNFLEYRDSKIVYRRYASLFFIAGCASTDNELITLEIVHRYVEQMDKYYGNVCEIFNFQKAYFILDELLLAGELQESSKKNVLRVISAQDAIEDTEDNDLFAKGLKETGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF4</accession>
    <name>A0A0B1PBF4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF4"/>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OMA" id="RTFSLEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="34591" checksum="BE6151EA030EEC18" modified="2015-03-04" version="1">MSSNEEVVELVPISLIGNRYLLFDVKSVMYLRRTYHICGTPIGTLPQIPQQNLFLGLPIELMKEEVEILTSRNIAYIVNDSTCHQERYGIKHDDDRSNYLESLKFQGLNIHRFLEAEKRSRTEKALIKRVDSCTNEMRNNIKNNLVDVNFIFDKLNQKSSNFQDNTGYLDDKNTYTDSVIVYKNCHAITPTTSYVPIPSQKSTHMPVPLPRSYALYKHLHESGYFILPGLRFGCHYNVYPGDPLRFHSHFIAVGYDWDQSIPTFDIIGGGRLGTAVKKGFLIGGLKTETNEVRTFAIEWAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBH4</accession>
    <name>A0A0B1PBH4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc finger (Hit type) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000161">
        <property type="protein sequence ID" value="KHJ36052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBH4"/>
    <dbReference type="HOGENOM" id="CLU_063513_1_1_1"/>
    <dbReference type="OMA" id="EAWNHDI"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="26020" checksum="DAC3BB2CB63BF70F" modified="2015-03-04" version="1">MVDMAIEDLEATLREVCQVEESRPAESDTLDKSPPSNVKKKAICGVCTTRESRYKCSKCYLLFCSLDCSKIHAAKHPTSPSPNTLLKPSSLGIKASDNSKQQPKSIGPFAPLDESKDLQRLFMLYPNLPNVLDKIHEATLPPSINSLSNSYIATGRSGRDKKEKSWTSDIGLQKGVKALHAAQGTGDIDSEGVREYIQLVLNIVHGNSEESAAEQIRRELLEHDNKIIEGLLYGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBM7</accession>
    <name>A0A0B1PBM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nuclear migration protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000728">
        <property type="protein sequence ID" value="KHJ34735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBM7"/>
    <dbReference type="HOGENOM" id="CLU_006265_0_0_1"/>
    <dbReference type="OMA" id="EWMYKYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="878"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1309" mass="146145" checksum="ADA46DE20B189517" modified="2015-03-04" version="1">MTAWDTEDEYAAAVPKSLPSPSDSSYSGRVKICLRSNSSRPVSPSIDRQEPSIDLDSIKNNFSSTFDPRILNPTLHANLVSEILTLRRALEAKKKQIESLETTLYETRGEHEIFSAGLTSISKENHSLKRKLELVEAGTSTALSELSKDREIARELAQEAKRRLEKAQKKIRSQDGEIDRVHALWARDKSSWEEEKRIIERRVHVAENRLKKILEEVAIYGINKTNKEYAEDKNNLDVELQEKPESDTESIRTRSLTSSVRFSISSGLARHGEYKTDGLSLADELNLDEKIELSDDSDYESVHSTSLSNHGRESRAESLGLTDQTNVCNKCSSRPCSPTQGRVSIKTLDSKISGEDNNGGAKNLEHLDSGNKISRSLSATSELQENVSLSPKEVLISEGHELRNNYLANLSLQDNSNSHEKKNRVHSNFSISVQCCSISPADHLSQEVPDLQETFTLPYRDYLLSLGAEERIEMKSKSIQTDEFALTSFKSIPPPVLIPSIHLHPPLSTPATPNQYSLPQQFKDKACQVSFLPNVKLKSTSMQTEEIRIDKRLNVLSLKIEPPMIFLKSKSAENSKALCTQTSLLEDSGTNCLKLPGSGNKIISDQSKNEDAKTYEIECSKENLDVTLDKNISPTLDSNIVGAEKINSENEFTDRDLSDLPRSSLSQPQRREKQNDLEQSTQRENLLFTNDTEKNIRVESSDLELSGNLSNPDELKTRINQIWSKTEVRHEQSCASISSMTTNEPPFPIPTRLSSRRPYLTLSLLSDCTKFPSLAQKRSFHRRSRSVHKVRSATTLSRAQGSSPGGNVKRNINGTPPLTLSPTSARQNSLKPYLNSSESFEHIYSMASSYKKSHIHTMAKNICNSDRIDSSSLDRTTSVISAIACGMIGEWVYKYVRHRGPIGVSESAEQPDNSKKVRHKRWVWLAPYDRAVMWSSKEPTSGTALLGKNGRKIIVQTVLDVKDENPAPKGVNLFHRSILILSPARALKFTATTMERHFNWLMALSFLAHSQQLPQPISPLTNSLDSKSQSQYQLREASTGDSVPAAIEMLNFTSKSSTGHNQSSQFISEVNPRMASEANYVIEDVNSAADAPIVPRYTDRSVSHITNTTTANYFSPLYHRKRSNTSPRNVATSSHKSSRPRLYSSKASKSTVVISTVPFENNDIKACKSRTIPTMNVHTSSANSNFHSYANMKNHGKINSANSEASMSTNCNDFETGGTVRMQAFISMRNSFAASETEGHQIGSEELKCQNIINFEENRFLSQEFNTKTDNNAESVDACIQENDLVTGCNQDKYQAHDRSDDLSPFPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN8</accession>
    <name>A0A0B1PBN8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative periodic tryptophan protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000717">
        <property type="protein sequence ID" value="KHJ34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN8"/>
    <dbReference type="HOGENOM" id="CLU_2110751_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="12398" checksum="5B001306B9D0AA3A" modified="2015-03-04" version="1">MAPSTPSSSKPVWLLQAHDKSVCAFDINPIIPGFMATGSSDKLVKLWNIQPSGPSMIVSRDLEVGKVFSTSFAPDQEVRFRLAVAGSKGSLQIWDTSNNSAVRNIFVDAVSRSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBZ3</accession>
    <name>A0A0B1PBZ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ap-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000280">
        <property type="protein sequence ID" value="KHJ35758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBZ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBZ3"/>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="446" mass="50440" checksum="3D88245C43699711" modified="2015-03-04" version="1">MASAVFFLDLKGKTLLARNYRGDIPMSAVEKFPVLLSEAEEESSAVPPCFSDEGINYLYIRHSNLYLLALTKRNTNAAEILLFLHKIVEVFSEYFKELEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEIQARPPIAITNAVSWRSEGIRYRKNEVFLDVVESLNLLVSSNGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRATRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECIVESHSGSRIEYMLKAKAQFKRRSTANNVEITVPVPEDADSPRFRTNIGNVHYAPEKSAIVWKIKQFGGGKEFLMRAELGLPSVKGDDDHGGGMTGGFGGSMGGVGGKGAKRPISVKFEIPYFTTSGIQVRYLKIIEPKLQYPSLPWVRYITQAGDITVRLPEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBZ8</accession>
    <name>A0A0B1PBZ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBZ8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBZ8"/>
    <dbReference type="HOGENOM" id="CLU_027694_3_1_1"/>
    <dbReference type="OMA" id="QCKENES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="60906" checksum="5CF24F0A95DBE846" modified="2015-03-04" version="1">MFAVPGWSISSTQLKTQTIHSDCTQVNSKNLSTKNLLATKKHKRNNREPKAKAIDLASKADQREKVREGKSKKKNFKKNVEKKTDKADSDIGAQNLAGQTITRTDNPKLKESKNDEKKTVDKSLNSKSLGKVDSLEKHFSNDESKTYISRKPSSRERTTLGENNERRNIEPDKSKNNSKLKLEPESSVCHTSLTKLQAAMRQKLLSSRFRYLNEKLYTVSSSHSMKLFQENPEMFNEYHEGFRRQVEIWPENPVDSYVAKIKKRGEVFKESKKITSSEKELVSPLPRTGGVCRIADLGCGDAVLSASLQSQLNSLNLKIFSFDLQSTSKLVTQADIANLPLPDSSIDVAIFCLALMGTNWIDFIEEAFRILRWKGELWVAEIKSRFGRIVKGGNQIKEDNVRKKVKSTKENKKEEKRKKELIENAIAAVEIDGMNDGGEETDVSAFVEVLRKRGFELQCKENESLDLENRMFVRMYFTKHHSPIKGKCAMKPEFPGDSNGKLRKKRSLDKFIEEDNSQQISSEAKVLKPCVYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD5</accession>
    <name>A0A0B1PCD5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000072">
        <property type="protein sequence ID" value="KHJ36327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD5"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="46353" checksum="9CF2E58B7ED90598" modified="2015-03-04" version="1">MSSDTEIQALPTDMRPTPPPPPAHSAHSAPFPFSPTSPIILTFDNNCEHYTQSSTSMLTPAAPSKRTAKSVTEQAPQSFEDESDQSYAYLPQDLWGNIKQLHRRERAWHVRLSICTSVICNIKSTLLVFKDDIEKEEADIIRNYLQQAIARLAASDNAQKFPPIPHHTKPPVTKRSTQEKVIPKKKASIIPLHAIEESQRTSIPQERIRWHKISPVGIREMIVKRLNVSPASIGLIKPVRSGFALSPCSSEAREELVKASGGLFLSGAKLEPANQWVPLLIPTVPRSINILQGHMEATKEMLSDEIERVSSVRPEALKFYGNHKSDAPHRNWLAFFTKPSKPGFRVFDESGITYLRSKLQLISANVAMDITLQNSVHEHPHVETVARICTLKIIAWPPLGAEIVEDLIDPTVKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL7</accession>
    <name>A0A0B1PCL7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000904">
        <property type="protein sequence ID" value="KHJ34384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL7"/>
    <dbReference type="HOGENOM" id="CLU_300942_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="994" mass="110359" checksum="1641F2CE51FD5AA0" modified="2015-03-04" version="1">MDLKINNMTLMDLSESTVKIVENKIDDLKNFGMLANTIISDTVETAITPIIQSSTTSNEGSSKNPHEIANSENSALKVDVNSEKNHDQEESVPHKQKKKKRNQKKFKSKGVISASQKESKCNIISQDPEPNITSEICKDIEGNQKHPETEITTDNSSIEAIHEERQADLSANQIQAPIICTDDAPTTEAFETKIMGPEFFEINPTNVEDVNVKSSLAESSILPSKTILITSENQQCGDLSNSDVPSGKSFSNLSTTNVKVQYESIASEDRESIKSLNESSKLKPYHPVKSSIDELVVGLNKNLDTEALNSSSLTNTNDTNTGSKPFESETASHFQKDENKVAFTPAKGESHSLVSEETSTEYLKSTTINEEESKVTVTSEDNTASPIKSNLASLSTVLTNSENEIVKGVDHTFSDIELRRLSQSNPESMHQLSSVKTNEGNDKTIGLSLRNSPEPADDDSEIIKLKNEIEPTTNSNLTVENPDINDELSEVKKFSDVLVSKNKDMTKETSDDNKEIKYAMHPEALASNAKTFVTSKTSVIYDLKETSDKLYGTLLNDKETLKDHKPPPVEEIITSFNCPPDFKKSSEITDFMTTNGKNNEYITHHFVKDHQCNFNESNITPSKENDSSTLTEDALTNGQYGKHSDPTHAAQVEASESLAASLHEKTEVENNNLSPNIQTKSKTNEYISVENWKDSLESTAENALSAIESKVTQVSNLIGILSHSISNSSCNETKKTIPPFSENDDQLNQTCIKHLKIEDSSYKDNLMHSIGSDFSGSKVKSEIVVDLDKEISEGKALLTPLITEIVGPSASQVEIANKNKLKFKHSLDEQALAPEIVTISKETLDLLYKKLHVMQLEIERLSSALKSQNEINRAFSQDTSNSSFRNNHEITESSNQSSKIMIREENLNVEPLKKPFQNKSSRNTSLWRFMSIFRYNSTTKLRTRLATRPKTETLPQSSLQLPKGKGKEINTQPKILTTRNCKIIGRVRAKDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDN6</accession>
    <name>A0A0B1PDN6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000063">
        <property type="protein sequence ID" value="KHJ36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDN6"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28781" checksum="B4D6C10E36F22590" modified="2015-03-04" version="1">MDSSHLSPLITPIPQLTHPLDLFNTSVANRQIRGPVPPSKHVLLEISHNDIGEGMKIVAIRQRRERAWHARILNCTSVIINIDSTLADFKDEISKKEATAFQASLRQAISKFAAHESLPTPPPIPSKSLQKKQSEIPNPKLPNKPIAKKANHVERLNEPRASSNSLRRQALEGNSTPPGNVDKRIFLRLPQEHEWRNLSPAGIREIVIKKLAISPATIGRIKPIYTGFALSPCSNDAQEKILEAQLGLYMSGAKLEPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDQ7</accession>
    <name>A0A0B1PDQ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative virulence effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000376">
        <property type="protein sequence ID" value="KHJ35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDQ7"/>
    <dbReference type="HOGENOM" id="CLU_2706642_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="8084" checksum="BE9EC44C3F33C83F" modified="2015-03-04" version="1">MICKQLECSLPDILLILRTVTGFAMITKDKETRKLLLDKSSIISAQNVTIEPASDLVTYKIPNVPVVIKSPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDU1</accession>
    <name>A0A0B1PDU1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000521">
        <property type="protein sequence ID" value="KHJ35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDU1"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="27231" checksum="24D76FD615E48C5F" modified="2015-03-04" version="1">MLSPAGLREVIVKRLSISPASIGLIKPVLSGFAISPSNEKSRKNLLAAAGGLFMSGATLEAASNWTPLLVPTVPRSITMLEGQVEVTKSMLADEIERVSTIRPTFVKPYGVSNPDAPHRTWMAFFSEIPRTGFRVFDESGVTRNSKKKKQIEFCKRCNGHHNIRTCSRAPSCGNCGSTMHSQDMCIAATKCRNCGGPRRSDSHRCLARPTRSSKPTKEQLKFYRKAGDREYQAVVRANAVEARAFSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE02</accession>
    <name>A0A0B1PE02_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative u1 small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0921</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE02"/>
    <dbReference type="STRING" id="52586.A0A0B1PE02"/>
    <dbReference type="HOGENOM" id="CLU_041869_0_1_1"/>
    <dbReference type="OMA" id="VRMIPTK"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="28458" checksum="F1B237D11B7B4785" modified="2015-03-04" version="1">MTTVYPSTNPIPPNETVYVRNLEERIKLPQLCEALEELFSEYGKIIDIVAKTNLKAKGQAFIVFDSVESATMAIEEVQGFELFDKPLQLAYARTKSDATVKREKGDGDEFESHKRRRLAEKDKKKAAEAAEEQKRIKRAGATTGVAPDAAVRPIKSTRGAGLKSTNASAAAVIPDEYLPPNKILFVQNLPDEYEVDALTAIFGRFEKFKEVRLVPGRKGIAFIEYETETGAISAKENTAGMALGDGTHIMKVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE18</accession>
    <name>A0A0B1PE18_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mipc synthase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000492">
        <property type="protein sequence ID" value="KHJ35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE18"/>
    <dbReference type="STRING" id="52586.A0A0B1PE18"/>
    <dbReference type="HOGENOM" id="CLU_036369_3_0_1"/>
    <dbReference type="OMA" id="NRHSWSF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="37647" checksum="C533B69D656B4604" modified="2015-03-04" version="1">MMRRGTAIFILINVAVILFLLNTCRTLISLLFEDGAADAIHSNEISTSYTNTLENRTRLIPKIIHQTYSNDSIPSQWVKGQQSCRNLHQDYEYILWTDIKSRQFIATEYPWFLTTFDAYPYAIQRADAIRYFILAHYGGVYMDLDDGCNRRLDPLLFYPAWLRRTVPTGISNDVMGSMPKHPFFLKTIYSLQAYQRYWGTPYISVMYSTGPLYLSVLWKEYMRDVRPAKEQVRILMPSDYQGYEKSFFNISKGNSWHGKDARTIFWMGRHWMLLTFLGFVIAIIFGGLLWILWSSCIMRTGRKNQWKDKEHYELINRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF44</accession>
    <name>A0A0B1PF44_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF44"/>
    <dbReference type="STRING" id="52586.A0A0B1PF44"/>
    <dbReference type="HOGENOM" id="CLU_103066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="2">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="23311" checksum="1D50402E11486AA4" modified="2015-03-04" version="1">MTTTKKALNSITGVRNDAQDKNSTGRAHQQYTKEKPVTFVCAGDKDLEIINVGPATIQILEDGSHTDNRFGAVSVTLAPNTPGPIPMWHRMNDTTFYITKGRLRFFISSSAPSSCLNTSCISESKEKPFRIVKAGDYIVVPPCAIHNFDNPFDEEAAFLNTFTPAYYIDAIRLIAKKTQKAVDEGRFPLDPEEQLEVMRRWATFPPPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFD4</accession>
    <name>A0A0B1PFD4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g3011</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01000327">
        <property type="protein sequence ID" value="KHJ35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFD4"/>
    <dbReference type="STRING" id="52586.A0A0B1PFD4"/>
    <dbReference type="HOGENOM" id="CLU_013724_0_0_1"/>
    <dbReference type="OMA" id="FANHDCG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="114"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="346"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="620" mass="70645" checksum="4FDA96BB82E6A90B" modified="2015-03-04" version="1">MTSNSQVKKQRLTLAQLAAYDDILTDALVDHVYFWATIRKNKSSYRSSRSFKEDDITSIIQRTVILEKNTEKAEFQLLELPGLRAFKDNLKTEKEKQDFIRHMQRYVKIYLPDCPWEVSTTNRYTIVTHEAAVTARAFIKRKQKIKYLSGIQVIMTNEELEVTQKNRRDFSIVFSSRKKASSLFLGPARFANHDCEANAKLSTCENAGMEIIAVRDIEIGEEITVTYGDDYFDDKNCECLCQSCELKSQNGWSKSNDLQSATAAEPSVKQSLHELICVDQSNSNGESHVNWIDQDQVIGPGIINKSQSNSSMYSSNADGSCSQKLFVNSKRKHFEDEIIITSAKKLRSKNSGDLTPMSAELSPIRSSFTPQSDISSRSEGHTSTDETSADDETELSKAQKLAPRVTRSLRSKNEGKIPNNQEHRSKFGKDEIRSDSSEMSRKVYSSHACDQKTKQALDSIHKPRNPLKNQLERYRRIGDFDHAPAIRIPGDYQLTSRLIVDLASGWIECQNCENYFVQVNAYTPRSSCPRCERHSKLYGYRWPKTEKEDSDDDEERVLDHRTINRFVQKADSKAVKKRHSLLTINPAKSNESLKSDLKAFGGLKLHNRVTRVLRSRNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG12</accession>
    <name>A0A0B1PG12_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mitochondrial outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000360">
        <property type="protein sequence ID" value="KHJ35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG12"/>
    <dbReference type="STRING" id="52586.A0A0B1PG12"/>
    <dbReference type="HOGENOM" id="CLU_055680_0_0_1"/>
    <dbReference type="OMA" id="RNAWLYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03054">
        <property type="entry name" value="GST_N_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="33521" checksum="FDA4DD07E5B18E4D" modified="2015-03-04" version="1">MDVASAENHRDKPGIFSVPTPVKKIFDKVPIVIYPPNRLPQRSSSCDNFPSLYVFSREQDAIVGKPSFNPSCLKWQTFLKIAGIDHSIIASNNHASPIGSLPFLLPALNGADSFSDIGNPIVADKMVKYSKEQGANVEEVSNMRSAAYQSLLDYRIRNAWLYFQYLESRNFNKVAYPLYVSSVSTNFLVRALISYQLRAAAESELLKFSSVIDIDDIYSEADKAFEALSILLGENSWFFGNERPSLFDASVFAYSHLLLDENMGWLETKLCRTLQTRKNLVQHRERILKKYYVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG52</accession>
    <name>A0A0B1PG52_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000232">
        <property type="protein sequence ID" value="KHJ35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG52"/>
    <dbReference type="STRING" id="52586.A0A0B1PG52"/>
    <dbReference type="HOGENOM" id="CLU_071893_1_1_1"/>
    <dbReference type="OMA" id="ILETAWI"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="243" mass="27488" checksum="A411A297AB086213" modified="2015-03-04" version="1">MDISDILNQFDSPSLNNSNANGEDIVEQIGEVGPTGEEDQRALTRAWVNEKATTELLEWPQDGLIMRCRTRVKNQIDLVERLTGNMDPKTNFSLIIIQTDVERWKFLIRSYLRARLAKIQKFALHYLSSPELQAHLSQDESVYAVRYQQILHQHYLNSFLGKFPMNLRNLNDTAGGISMIESPDEEASIFVRGLGSRDGGDTVHVSGRGRNEDGEIGITRGEVVVAKWSDVRQFVKTGELELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGH9</accession>
    <name>A0A0B1PGH9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000058">
        <property type="protein sequence ID" value="KHJ36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGH9"/>
    <dbReference type="STRING" id="52586.A0A0B1PGH9"/>
    <dbReference type="HOGENOM" id="CLU_022453_2_1_1"/>
    <dbReference type="OMA" id="RRYKSAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="136"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="38115" checksum="9C97B902E6EA3B71" modified="2015-03-04" version="1">MATELSSNWIKLQATLKHVSPKSKSRRSSFFIESKNNIAIKRRRLDTNYQKISTLKTSSGTRLMSSVCSEDSHGSSKKILPESSSQKLCSLKLWAQENDISASDLAEAYGGKLQNIITEISDVINEGLRDKVEIGKYVGIDCEMVGVGKKDRSVLARVSVVNFHGIQVYDSFVKPIEFVTNWRTKISGISASSLRTARDFKEVQKDVASLIKDRIVVGHALWNDFKVLQLSHPRRDTRDTSSLSVFRQYSHGTPSLKLLAEKILGVEIQNGQHSSIEDARATMFIFRRYKSAFDAEYLNRFSKKKRMSRSTSKSGSKTKSNSKSKSQSKSSSIIKSKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGK2</accession>
    <name>A0A0B1PGK2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000171">
        <property type="protein sequence ID" value="KHJ35991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGK2"/>
    <dbReference type="STRING" id="52586.A0A0B1PGK2"/>
    <dbReference type="HOGENOM" id="CLU_030037_0_0_1"/>
    <dbReference type="OMA" id="DRRFFPR"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="629" mass="71352" checksum="16CBDA786BCBE8A8" modified="2015-03-04" version="1">MDSLPPELILYLVEYLDPIDIAILQHVSRRLYTLTRDNVFWRLQCFTHSNFMSSIRRREGRLKSLKNAILTSSAENLLEEQKSPENSHLLSKKIKLKHSTEYFRILANWDPSYPSEKVDWYHEFIARNAPISLNWLEQPMSMISNQKKYLEVKGMGIISENDEDKESNCTRGWVVSSVEDGSVCLWDIRDLSSERRETRGTIAARSREYLLSSNLSCSKKQFKTMATECVSVDSRTKKAYFAAENCLIEIDLETLSEVRREIFPFPISALSEARYPVPLTVGTTQSLHLFDTRAKFKTSIRESSSEHTDCYNYNVDHRDSKSMLSINPKDLLRLRDWPGCAHLQGPGPLSILHMPNSGTIDSDIYLAGRFPSILVYDRRKFPEIGWTIHSGARLSSIDWLPLTIASEERDLARYGELSIHQVEKTKTQTGRTLIACGEYNSKGSLEMYGLSSTINSSKDLKYPGYCLNYSRKNRQTSSNSKLLAVANHGTRIVVSDGGGNLRWFERDGFTQSRCWNIAKNPDELSRGVFGTQQALGTDTGTDDIIIKILGTASCGNQVKNSSYGDLIVWTGEKIGLVNFSNRSKRVMPEMEESAEKIEAMYVERMRSALVANADEVRWMRDLGVGAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGW0</accession>
    <name>A0A0B1PGW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metaphase-anaphase transition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGW0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGW0"/>
    <dbReference type="HOGENOM" id="CLU_025221_1_1_1"/>
    <dbReference type="OMA" id="DSAHEWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="352" mass="39380" checksum="04EAE1AFB5A0CE4B" modified="2015-03-04" version="1">MYQCLGLGTADDGGCGEDWWHASCIVGIHPDCVENIIKEENVQISRNENQGSKISNIDQTRQEGKNVEDNCSEPLGLQTPIQYDDMGQPIPPGFPPEDSFEGFICYKCLDAFPWIKRYAGAPGFLPAVFRQGTTKKCVSKMGDQFQNSNFRKRNLNEVETLVADTPKRIVKRKKSHDSSEGGLSGNFDKLVEGSIDSKTSCKLEHLPPAQSGQFSLFFKEDFRLYLCRCDKCFPKLKAHPQLLELEETYEPSVSTDFCEEPESTVGSSSLYEQGESALQNIDRVKAIEGVMAYNHLKDKLKPFFQQFAESGRTISAEDIKSHFAKIRGDDEAIFEAGEAAKLSSNRHEQSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGX3</accession>
    <name>A0A0B1PGX3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine-threonine rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGX3"/>
    <dbReference type="STRING" id="52586.A0A0B1PGX3"/>
    <dbReference type="HOGENOM" id="CLU_053381_0_1_1"/>
    <dbReference type="OMA" id="GVTWNMT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062150" evidence="2">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="34248" checksum="576112F342AB4272" modified="2015-03-04" version="1">MKLTSVTVLFFTFCLSVTSSDTIIENSLSSLGIKPGVKDSKQSDSNSSGNSAGRAETGPSNQGTNSGVDVKVSSSNNVSGTQVIVIWVNNGGTESTKSVNQSPMAAGATHRVIVGGSKGLIFEPEQITADVGDMVIFQFMSNNHTASQSTFDNPCQQLPGGIDSGFLANPNDSISPAPEIAMQVMGSDPLWFYCKQGNHCQKGMTFSINPGPEGSGKTQADFKQKAMSSAAGAAGPPGAAGPPGAAGPPGATGPPGAAPGAPDKPKDQPKDQPKKDDKPKGSQPSPQSPPPNKPLPPPVMAPGSGNGAGFTCSCLCGVASFPSVGSQGIGSFGGLPGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH33</accession>
    <name>A0A0B1PH33_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1908</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH33"/>
    <dbReference type="STRING" id="52586.A0A0B1PH33"/>
    <dbReference type="HOGENOM" id="CLU_011815_0_1_1"/>
    <dbReference type="OMA" id="CEFCFVS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="59"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ36156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="382" mass="44027" checksum="D3A22868771DCB7D" modified="2015-03-04" version="1">MSGNEPFALNRIRTRQKKFPDASLPTETASDRSVRSNFHECLVKNQSPSLTRKSKKSNKEGRNIENVTLGDVRFQAWYSSWYPKEFLGKENNVIKNLFVCPRCFAYSRGEEKKEIWAWLKHCQNCKMKAIPGKKIYVHGEWIERIDDTPITNMETWSVWEVDGATETVFCQNLSLFAKLFLENKSVFFDVSGFKFFLLVYAAPRASSAETLESQIIGFFSKEKISWDNNNLACILIFPPWQRKGLGSLLIGISYAIARRKNIMGGPERPISDLGLKGYRGFWDIETISRETWISPDDCLSMIKEMDVLDQNYDISDSLSTSTKPSNETTKYEICYKRLGDKSQVSIDRRRLRDWVVREGLQLVSIVSEKGFRPEYCLNDGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH48</accession>
    <name>A0A0B1PH48_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000123">
        <property type="protein sequence ID" value="KHJ36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH48"/>
    <dbReference type="HOGENOM" id="CLU_163547_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="96" mass="10445" checksum="82B3701FF7F39665" modified="2015-03-04" version="1">MRQRRECHGCVLCDTKGKIGREKSKSSPSRGGGVNAQYALHVWDSQEDSKNPSFPSGLPSGLPFITAGLNRLRFYITPPLSTFFHEAPAIGPGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHY3</accession>
    <name>A0A0B1PHY3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHY3"/>
    <dbReference type="STRING" id="52586.A0A0B1PHY3"/>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_1"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904408">
        <property type="term" value="F:melatonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="39544" checksum="609C18E51AEB4C1C" modified="2015-03-04" version="1">MGAQDVLSRKVGVIVGDDVLRLFKYAKEKKFAIPAINVTSSSTVVASLEAARDSKAPIILQMSQGGAAYFAGKGVSNSNQEASIAGGIAGAHYIRAIAPTYGIPVVLHTDHCAKKLLPWLDGLLDADEAYFKTHGEPLFSSHMIDLSEETVEYNIETTAKYLKRAAPMKQWVEMEIGITGGEEDGVNNEDVDNNSLYTQPEDILNIYKTLAPISPYFSIAAGFGNVHGVYKPGNVKLHPELLGKHQKFVKDAIKCIEDKPVFLVFHGGSGSTKKEFYDAISFGVVKVNLDTDLQYAYLSGIRDYILKKKDYLLQQVGNPDGEDKPNKKYFDPRVWVREGEKTMSARVTEGLIDFNTAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHY6</accession>
    <name>A0A0B1PHY6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000133">
        <property type="protein sequence ID" value="KHJ36129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHY6"/>
    <dbReference type="STRING" id="52586.A0A0B1PHY6"/>
    <dbReference type="HOGENOM" id="CLU_2833066_0_0_1"/>
    <dbReference type="OMA" id="PFTIQYC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Longin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="66" mass="7460" checksum="4CC9E13A37DCE3E5" modified="2015-03-04" version="1">MIHSTQISRLDGLMLCASVDEEQNEASLSEIKSQVKKILRRLNRNSEGQASIESGPFTIQYCLPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVK7</accession>
    <name>A0A0B1NVK7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative exocyst complex component sec3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004375">
        <property type="protein sequence ID" value="KHJ30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NVK7"/>
    <dbReference type="HOGENOM" id="CLU_002075_1_0_1"/>
    <dbReference type="OMA" id="SFMRVFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1307" mass="146729" checksum="156C098A37AFD0A4" modified="2015-03-04" version="1">MNIAVSESYITHIRIEEDGAYPATPSPPNGNPDSKKLRTIIVAVRKTGRVRVHKARENANGTFSIGKTWVLDDLTAVQSFTGVTPPGPNGEQHKLWAGSTGFIVTLGKSYYWKANSQKEKQFFIASLVKIYHKYTGGKLPELICFDQRERDQLMGVAKIPPSQISSTSGSSGSALSPQTSRKFQRDLGITEESDGEYGKRAPVLSGMSPVKKGQIRTKRGSQSSGSADLNMLPSSSSRNKYSVARLSSNQSQKSFGQIDDGNYFSQRPIDTNQFLDKEGSFVGTRSRRDSENNMQIPAPLSLPSDARKFLSQEGDSREPYPGPLKSAISASLNNPLLRLEVNLPGLNVERIQLDEMNNVPGETVLVPSSSLNTEKVRPDETSIGLGPILKAKADVGGIFSGAANAFNSLKPMVEGATERFRDLKSKPLEDSDVAMVNISGQGFLRPSSNSSSLLTSSTLPELKISLDNGEDTISQEKFLLSNRVNEESTSLISVDGLPEKSKARTIKKAKSPNEIMNKKLATLGVDPLIISGRSNDLFNIWEQFGWVGEGIRTKNIDEMKDEVERELCRTQAGGWLNRLEEEDERIEAIKMVFDKVIEECDEFDGLLTLYLVELGTLNEDVAYIEAQSQGLQVQTANQKLLQAELQSLLQTISISPEQIESLRESSLESTRGLNDIETSLVILFKAMLTIDPSLGVSSPRRSEDGSLSSGKPGVYGNSEIGSMRVLQEKKDVYKSEITIFLRRLKQFLQIKFAAAFEQTRLAFEREKSNNLSRVSGRVKLDFGKHDLARNILWKYSPLMLFTREVDRLEWENLMNIYGQVLMSLYQEEFREAFMASRRAARKLTGDEVEALFTSQVEKQSEGLATTARKLTVMRSQNLAKSLLSQGGDNNGKSSLDKGQGLEPYEVIEELISRVTSVMSMEQNFFVEFFHVTSLGLHDFPETVAASSPEDRRGVDIKRPRVMDPNRDLAMLVVQSMEEIFSFFSREFQGLVDWSLQLDPLQVVGLIAALERKIPEYEETNQEYLNRTLQKLHTQLIGLFIKFLDDQIRVIEETKVKIKKRKGVIGFMKTFPLFANALEKKLLGAEDLEIRSTVNNAYSRVSKAMFEALKVIARESPSVQIAGTDQAEKEALNYEIMLMQNMHYYLEEVDPRSNPILEEWKKNASDEMNEHMALYLNAAIRRPLGKLLDFIESTENMMISRQPGDSVLKISSMPSHSKSTFKKVLSNYDAKEIRRGIETLRKRVEKHFGDEHDPGIASRNDLVRIVIQNCEKFYENVEDRILTIIRDVYDGEIVLEWTRTDISTAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVP6</accession>
    <name>A0A0B1NVP6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arrestin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005494">
        <property type="protein sequence ID" value="KHJ30043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVP6"/>
    <dbReference type="STRING" id="52586.A0A0B1NVP6"/>
    <dbReference type="HOGENOM" id="CLU_008578_1_0_1"/>
    <dbReference type="OMA" id="FHILSCK"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="464"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="875" mass="96689" checksum="4899EE1E9FE9AE22" modified="2015-03-04" version="1">MPALISYTTKRGVIFYTPPNSPSTESEVARLPLPPCRPRARRPYSIHITRLSNTTDSSPNKRSSKHIDLKTIFSYKTAKKLLVSALTTLSPKAASVSHRITSSYSEDSERPATHNSPPIRLTSAGIFKENFNARKKRRLGGISVMSRSSIGGNSWRPVYNIETSSGNTTSSTSPRTGAIGIPRPMTLQQCTNEMEKPLVSGNEVSCSIILAEPVIFLMGLDHDGSTRDCNGANAMSLLRGTLRLNVTKNAKIKAVSLKFSGRAKTLWPEGIPPQKQEIVEECSLRTQVIPFFNALYKGSDSSYGDLCNYVLRDSNSALSLSSNKASEPLKQNQLGGFSLTGITNRANKNSTVPMASEGKKMSAPSIQLTSQQMSDSSHNSVQTKGYKVFYPGVYDYSFELPIDCNLPETTNLPLANVKWELEATIERAGAFKPKLVGRKEVPVVRSPSQDSLELVEPIAVSRTWDQQLHYDIVISGKSFPIGTKIPIAFKLTPLAKVQVHKVKVFLSENVEYFARDRSVHRKDIKRRLLLLEKIAGKPVAKEFWPSEVKIVGGERTIEEREMRRSVAMQRREAEAVRNNTHPVPLPESSENILGDIDLGVEEWWGQTEIEMNVQIPTCETMEKDRTKRLSHDCTWSNVNVHHWLKILIRLSRADADDPTKRRHYEISVDSPISLLNCRATQANISLPEYSGLDLEGQGVRQVCGCQSSTQASRVSFSHTSSNEIISTSFQSGSNLSRACSSRPELANLPTHLLAGAQRPIHLMRSPSFLPPPFDAEEPPPPIITPPPLYDNVIGTPSYDGLADYFSRLGEYEGEVTEDEDTITSVNHNFVNVPNSFTNMTNGQHTNLVGLNQDFIFGVSGTNSFITGSNSGVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVV1</accession>
    <name>A0A0B1NVV1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cyclopropane-fatty-acyl-phospholipid synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005132">
        <property type="protein sequence ID" value="KHJ30103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVV1"/>
    <dbReference type="HOGENOM" id="CLU_020424_0_0_1"/>
    <dbReference type="OMA" id="DVWMKDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="492" mass="56176" checksum="7DF7450BBE31A15E" modified="2015-03-04" version="1">MFPVKHSFSYSYLLTGVPIGFKGSVGGLISVDEEKKNWVSRKSWFTVHGDDYLARGHHPDGLKGKLQDFLASQKIDHTQYSHAYLLTAAKFMNYSSNPVSIWHLYSQTNELKALVLEVNNTFDERHNYFLEPLPKPLNISPNAGCVKTRYTSKWPKNFYVSTFNDRSGRYSLSAVDPLAPNLTGSGYINMNITLSGPSNDNAMIVTLLRSSNSPLYPENMSAFEKLQFLSKWWWVGFATFPRTLQQAFKLFFRRKMPWAFRPEPRQGTISRPADMTEMFIEKHFRAFLRNRVEQSEEAVVIRYQSAGLSGENNAACIFNPTKLKRDAVLNYEIVVLTPAFYSNLLLYSSLRNALNYESAKNETISLSRHDLISKLLVENSESCIPSLNILGLSSPTKSVLLALSYLRNDPLLKANRDKTSTPNSNPNFPRVSELDTFMLQHATPAELRTYTWKLARLVMIDHIALNSLILWDLEVFFAHTLSLFFLLRKTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVW1</accession>
    <name>A0A0B1NVW1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005094">
        <property type="protein sequence ID" value="KHJ30113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVW1"/>
    <dbReference type="STRING" id="52586.A0A0B1NVW1"/>
    <dbReference type="HOGENOM" id="CLU_032998_2_0_1"/>
    <dbReference type="OMA" id="MSWRNPL"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061517" evidence="3">
        <location>
            <begin position="33"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="334"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="45318" checksum="5B86F0019603008B" modified="2015-03-04" version="1">MDTRTVRHVSGDFMARILCSLVLLQGLQQVTAFSLKLHAVEANNSSVLQNLPEQLKRFFHHVYSGLHDSHQLQLHLPDLKSFQEGFSSVATTSATIFFLVYLVTLMTNWARSIWNGGRPRLLSPFGSRQHPPKVTENDYSYITSAEITQPGRTYNQTKKPPPGPGIETVGDVLVLKNGVDSYPIRFPVNSIYEGKLRVIDVKERLAAVLNLPRGGERIIDLQYKGISLNEDLKACRDYGLKNESWIYFTIDSKTSHSDESTVDSENPEDKKKRRRGRKGKKAASRRREPSISHQEVSRSSRSVTPPTQRTSGPIDKLTKLSNHLHTNLAPLCYQFIESPPEDEKKKEFEYRKLSETMMNEVVLKLDAVETDGDNDAREMRKAIVKEAQEVLIKLDAVMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW74</accession>
    <name>A0A0B1NW74_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003828">
        <property type="protein sequence ID" value="KHJ30637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW74"/>
    <dbReference type="STRING" id="52586.A0A0B1NW74"/>
    <dbReference type="HOGENOM" id="CLU_018596_2_0_1"/>
    <dbReference type="OMA" id="AHERYFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="200"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="449"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="60005" checksum="97FD3ABB32F95AB6" modified="2015-03-04" version="1">MSFVCIRDDSYVTDEPNNNPATPSKSLRKKKLTDITPIKNTFLNQDFTPLDKSQSGKDKNFKNRIEKNHDRSAKKKSVKTLIERTILGNLSEENEDDEDLAQKICNFEEDDDQKDYINCDLETSTSLATPKKSRGSKESKNKLSIVTSTFDLTPHEIYFKENKPGHQKTSNNTLSSLELLDHKEYFSRYYNLRNLYQDDLKNLEEIHLDKFNQWQFELSQDFNLCLYGFGSKRSLLMQFADYLYNARKFQERSEIVIINGYLSTITIRDIFKTVASVMTSEILKFSSPPDMLETIFGLLDQDKYLDIMLIIHSIDGHVLRRLPNQNLLARLSSHPQIHLIASADHPSFPLLWDSSLRSMYNFLFYDCTTFQAYNAEIDVVQEVHEILGRSGRRVGGIDGVIFVLKSLPENAKKLFEVLIKEQLKVTAGDCNTFEDDKDDEDQRSRYQETQLGIEYRVLYQKSVEEFICSNEINFRTLLKEFNDHQMIQSKKDAIGSELLIIPFSREELKLILDDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY09</accession>
    <name>A0A0B1NY09_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003553">
        <property type="protein sequence ID" value="KHJ30828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY09"/>
    <dbReference type="STRING" id="52586.A0A0B1NY09"/>
    <dbReference type="HOGENOM" id="CLU_045495_2_0_1"/>
    <dbReference type="OMA" id="TWRVERW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="235" mass="27626" checksum="22AC813ED67F39DD" modified="2015-03-04" version="1">MNSIRRIRELNQRELENGVSSEGSWHADYRDTAYIYIGGLPLELSEGDIITIFSQYGEPTYLNLVRDKETGKSRGFAFLKYEDQRSTDLAVDNLGGAVILGRTLNVDHTRYQRKDEKREEDHEPSLELDTTYRSYDKIIDQDKSHDERPMIKEEQELVNLLRDLDDEDPMKSYFVQEKKDQIAVALAKLKSKKCHKNPRKHRIHHHGSRNRSLSRSDRNKRDPRLNDSGRQRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY56</accession>
    <name>A0A0B1NY56_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative protoplast regeneration and killer toxin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003484">
        <property type="protein sequence ID" value="KHJ30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY56"/>
    <dbReference type="STRING" id="52586.A0A0B1NY56"/>
    <dbReference type="HOGENOM" id="CLU_000288_126_2_1"/>
    <dbReference type="OMA" id="SETCTIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="691" mass="76556" checksum="C0F8497F2C2D70CB" modified="2015-03-04" version="1">MATIPSTPVMRDSISYKSFHNQESGVESLQSRADLNFEEEKITRQAWLHEISKDTFVNDHEQKIKVTQKTKIKPVQNNRLEEVSTLVIQDAPFRPLPSVITNNQSQRVQPQSVIMSSGNSSDSIRSSSGSSASVDLRHSRTDSDQPEEDQHYLPDEVAQVPPFQYYHQKISSDNLNTNPTPYISAIELGQSTNRYLTPTLNSKARNYSQRPISTYSDLGPRRKSPGSQQSQSPRSASRVISNNSGHKFHDGRPKSCIDLSNTSYPQPPPPPISLDNSQLRSVVGSNASLLSTSKTIEMYRQNLKKLNDSETQYAFAIYLLQAAQEHNLNQETDTATKKKHASNCEGRNQVYQNFEQPSSSSQDLIQEAKHILQRLANQSYPYAQYYLADGYASGLFNKGKEDYSTAFPLFVAASKHGHAESGYRAALCYEFGWGCRKDPAKAVQFFRQSASKNHPGAMTRLGQACLSGDLGLNKYREGVKWLKRATESADLQYNAAPYHLGLLFETGYGDDIFRDETYAAQLFTQAADLGHSEASFRLGEAYELGNLCCPRDPALSVHFYTNAAQSGHAGAMMALCAWYIVGAEPILEKDENEAYEWARQAAACGLAKAQYAVGYFTEVGIGTRPDPLEANVWFVKAAEAGDERAKLRLSAIRAATSEGKTDTLQTRSSGKIRKSQSGAESANPSETCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYC0</accession>
    <name>A0A0B1NYC0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005545">
        <property type="protein sequence ID" value="KHJ30035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752705_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="368" mass="41815" checksum="4C6C97BBC93991FB" modified="2015-03-04" version="1">MWGEAKTSYIDYVISTEVDMSDNPPLSNFHPNSPNQTTIRKDLSNFIEEQARVFNTRLAEAQHVINQFTTLYESISDPEIRAAMKEAAVGIKEQLRAILTGNIKKATNPSQSNRKTLIQKTVEQKKPTKTKDQTAVPTCQYKEHSQINQGASANKNIKSKAATQDTWTEIVRRRPAKNVVDLQTQEKVILPSIPPENMPKVISKPDPRLFLRMGQDHPWRRVSPHYIKISLAKKLKVASSAITQVTRVNSGYAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRKPHIQLDPTLCNRGPKIRRKVIWRKWPPNRIPTKAENWTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYT2</accession>
    <name>A0A0B1NYT2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004823">
        <property type="protein sequence ID" value="KHJ30195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYT2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYT2"/>
    <dbReference type="HOGENOM" id="CLU_977259_0_0_1"/>
    <dbReference type="OMA" id="GIFRYGA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32453" checksum="F826547DC414368B" modified="2015-03-04" version="1">MAFGFVDDTNLVVWGRSARENCYTLELAHGKCLAWAKRYGAEFAPEKYQLIHFSRKRGSSEDLKEKIVLEDITINPRSEIKVLGVLVDSRLRWGPQLANAVQKGEVAINALSRITSSIWGPSVRSSRLLYTAIVRPTMLYGSQVWGIRPNGGSLVKSLLGKLEKVQNKSLRRITGGYKRIPRAILEREAEILPLDLYIQAGIFRYGAITEHKPVTTEILRHINLMWDLFSRSYKRRATVTRKATAMEHNRHEARSKMEELNTTVRPRNLISQLQGSGIRNQDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZQ4</accession>
    <name>A0A0B1NZQ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002548">
        <property type="protein sequence ID" value="KHJ31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZQ4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZQ4"/>
    <dbReference type="HOGENOM" id="CLU_019472_1_0_1"/>
    <dbReference type="OMA" id="MRYIMTD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="3">
        <location>
            <begin position="104"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="104"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="60072" checksum="0075F3514C5D4092" modified="2015-03-04" version="1">MQMSRSISNIQPGVDLCTMNTHYEECITNSLISAPRDILCYASNDGQLIGGILEAQSPHLSFERCDAIDSSSAHTYPYTPKCDGFPTTFEDPFTIQPTLDFSALSKNSKIKTKESKNSQAMDNKLLGFSGPILRAAIFDDTGQTWPIMSAELYGMFFVAEDVFGETNARGDELTCYRRNLFQISGAMILSRGMNGIINEQGQHIPIFNLEATLTAFESIEGKNAEIISVPWKTSCNTSEEKSGTTPSSLPLDLNINPELDPSNASIPISWKRLQFKHATANNGRRKGLQQHYIVQVNLVATLANGEIFKLAEIQSGPIIVRGRSPRNFDSRNRDNEKKCDVKVNQPNEPSTPTRKIDYDVMLNNYTFANSEESSQPCSDVSEWKYNYETSPMDSRPSKSRMLSLSTFSINHSSLSNSAWALDSPNDRSFSGSSPIELPLTEDEINPIRSLSYNKNVRKGLPRSPVIQKFKRGLSYNSLIENTDFLYEYFPLTVDDWIPPVDAIYRPHVVHHTITPENVRAEQNLYKRKTYFSAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX6</accession>
    <name>A0A0B1NZX6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002475">
        <property type="protein sequence ID" value="KHJ31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX6"/>
    <dbReference type="HOGENOM" id="CLU_064352_1_0_1"/>
    <dbReference type="OMA" id="IATKHES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="25278" checksum="36ABB9D47AAF0FD2" modified="2015-03-04" version="1">MVALVSYSSSDEEDEPSDKSLATNTRISSSKHKGKAASISGDTPPKPLSGRSPKPVTTCEPGVLSAAIQGPQLPDFGTEYALSEDSDFEMLSPYSKNRVILRNLTMSKQPNFEIPPSPKGSPSNSTEAKFNQFLELKKKGVHFNQKLARSTAIKNPSLMQSLMDFAEIDHSGQYVTTLPKSLWDPGAFPSHAFVEELNKSQQKILNLRENSKAIGQRESVDFVSANSGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P003</accession>
    <name>A0A0B1P003_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004707">
        <property type="protein sequence ID" value="KHJ30231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P003"/>
    <dbReference type="STRING" id="52586.A0A0B1P003"/>
    <dbReference type="HOGENOM" id="CLU_153395_0_0_1"/>
    <dbReference type="OMA" id="SAMIDWI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="131" mass="15439" checksum="85F117167E857B98" modified="2015-03-04" version="1">MLLEERYRDNLTAYWSSNAPTRYRDLEIGMAYWLPPELFHIPRKSLGRLLVARSGHGDFAAYHRCFNHTEAELYCFCGQEKSLELTFSCQLTRKNNGGRRNFRGRNTRENIKWILSTKSGAKAFHQRFCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P005</accession>
    <name>A0A0B1P005_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sister chromatid cohesion acetyltransferase eco1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002449">
        <property type="protein sequence ID" value="KHJ31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P005"/>
    <dbReference type="STRING" id="52586.A0A0B1P005"/>
    <dbReference type="HOGENOM" id="CLU_719589_0_0_1"/>
    <dbReference type="OMA" id="MVYAFWE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="2">
        <location>
            <begin position="297"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="44684" checksum="3E5C9A480B8E969D" modified="2015-03-04" version="1">MTGASRKKTYSRRVATVSGEPANKKRCIGRITTAYLGSQYESSTQEKNSLEDSSPKFGYDIRKFLLPISSASISLNHETASRSISLSGSQTKRKKRRLRLNVSEAREISAKPTENHISSPRLIQQTIASSGKELVNCKTCGMVYAFWEEKQHNLYHQKLNLEFMPVIRCKKATIYEQEFENSSLCIQVLDRYIEKNLRSLGEKAIQLSSSNGLEMEHIESNSLWGLIPNPHNNSDHGQVLHYKLYVMFYGPQLVALLLAERIGYAEVFDYTEYDSLEYKTEISREKQISDNKNNYRKVFMSIERLWVHKNFQRKGLASMIINEARKNFLYPIVLSKNELAISWPTDDGDKFFRRYFNENSSLAPYLINVADTTRLKSHKNISLKLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P048</accession>
    <name>A0A0B1P048_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004815">
        <property type="protein sequence ID" value="KHJ30199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P048"/>
    <dbReference type="STRING" id="52586.A0A0B1P048"/>
    <dbReference type="HOGENOM" id="CLU_634567_0_0_1"/>
    <dbReference type="OMA" id="CYRNTYA"/>
    <dbReference type="OrthoDB" id="5386093at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="450" mass="49199" checksum="995FBF38D3EABDF8" modified="2015-03-04" version="1">MLPTSEVNLQQSETQKPAPTAKAELSKANLDRSICGWLGGQSQLPALCAGASSCIRDTEHKYVGCCETIGSCTAGFYTSCVDEGSDGWSPPSSIQTNGIYTCAKNEECYRNTYAENYYQFGCGKSSWATRVETTFTGQPPDITLQLVYTAVTFPGATTDRPTATSSEPPMILMSTNSMSSPSSNPQNTEKVDPGAVAGIVIGVVNVFVILSGLILCIFLRKRRQIRRRNEQPLNSPTNDSNVRSVNPMHRLSAVSHIPKILPTPLRINPSLASYRSPHIAKPSSHNSPTSSRFSSQKVPLVSSNPERDRFIGSISESNDNHSTVPLNSDWHSKVGVGTSLNSRNFKSPNFQTSSPIYRNTEIEDDDTLEYHSVSGNLTESPRSRESRPDHDVTSSVSLMSDQEEMLATASIRHMTHIRRGGNGGYHLVDQVVNDEDTPESRNQSSHPNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0A0</accession>
    <name>A0A0B1P0A0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002681">
        <property type="protein sequence ID" value="KHJ31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0A0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0A0"/>
    <dbReference type="HOGENOM" id="CLU_013929_15_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="147" mass="17032" checksum="04367D46F889279D" modified="2015-03-04" version="1">MFEFFIIFHVAYLKTMTKLTINAGFRGARLVPFDPEAVIMKLDVRLWTPKITELPFVDIDSWISWKTWNITKALLLSVLVKNRILQHQKSSLTPIFQTIAAMGKVMETIAHEITLLTAELPTLRKVNESPRKRYWAIKTRIRHGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H0</accession>
    <name>A0A0B1P0H0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative forkhead box protein l2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002619">
        <property type="protein sequence ID" value="KHJ31743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0H0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0H0"/>
    <dbReference type="HOGENOM" id="CLU_012536_0_0_1"/>
    <dbReference type="OMA" id="PNDAGWQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="214"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="214"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="752" mass="83276" checksum="F9C094AF4D963FD4" modified="2015-03-04" version="1">MSSFTPYPQPRLQIYQDPDQSATMFQTMNQTMSQPAQLGRLRDASARINIMFNPPPQTVTAAKSPQKTAWRPSKSHSQTSLSNKLNMVLIPPPGSNNFSTDSISKKQPLMSKFKPPKALFATNMPCQSQIENFSTLYSTPFQNDYISEDIYLEQRLSDSSNRKRLLNAAPIIDSRSCKKTKMDESVVFENCDMEKNIELPAPDSFPPLFDDGNKPPHSYAQLIAMSILRAPARRLTLAQIYKWISDTFKFYSATDAGWQNSIRHNLSLNKAFVKQERPKDDPGKGNYWIIQPGMEFQFIKEKLLGRRNLNIAEQPPTMPGRSTLPSAGSPADHLSASGAPSTPDQARDSAIKSESAAEISSDATIPNSDSADPEGKGETKITNTSTFLPQQGSSPPSPPLRSSPPIFCNFYKETPLPVPLIRSSSLSGCQQSHFTPLDDSGYYSSLDSSALRKPNRSLSDMDPTPGRPRGRAEDEIARLRGSSCDSPTKIRSSYVTASASASRNLAVESLPILTPLTPAVKLYAPPQAPPSASPNTNLRRHRDRVREMVGSPLRGMTTLEESFSWSPAFSLEEGSYMFSTAHDLNDEIEMLDETNFRFPSIGTGSPERRVPKRTRHDRSRSINRTSQVSQTFTNPVLNPDSSIRLSPEFYSPIKKSSNKSSNLQFHDNQSSCSPSKPGKCKIPALDLETFNLPQEDTSTDTDLFTDDSGKSWDIMQGFQKIGTGKTKGIFCTGKNSSKVIRPSMVRSCTFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1A1</accession>
    <name>A0A0B1P1A1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003288">
        <property type="protein sequence ID" value="KHJ31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1A1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1A1"/>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="OMA" id="WWGRRWH"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="355"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="541" mass="62836" checksum="C354D2874CF58636" modified="2015-03-04" version="1">MEHYLSNLTWAGSIPTSNEIYSVYRDVLEHKLSNGTLILVIFPYHLLGFLLMTAYLCIPHKESPKIYALRWPLLAFINWFEFRMIWKTSSVGPGMGSFAGSLSAYTILASWTWLIFKKPQWEAKRIQRIIKRVPQIKNEITSTKSEDEIPQNKDLRQRNANGSLKASSLSLRKDEFQNDNIDVYHYFWQSYPDNFKERISWVVDLLYNYRGPGWNWAISSIPSLPPEILMRAGDPVPKRNLSNFSPTGSRRFNSRYEHLVYRVSLLLFCYFALDVLKTVMMKDPYFKFGPNTYALPSYLQSLTPSALQFYRIVVTSIGIITVMTTTLNLIPLLSCIMGPKVLGLRAEPWYYPTEWGYFSNIYKNGLGGLWGDYWHQSFRLHFTSPTNFLIREGYIKPGTFIAKTTSLFCAFFLSGFLHWASSSSTLPPTRPSHAMYFFVLQGVGIMLQRALCQCFSRYITKFPTFLRRTGNFIFVLIWLHKTGWLLADDFARTGLWLMDPVPISFSQLLGFGEVDAGWISKRRQFRWFQGKNWWEIGFALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1A4</accession>
    <name>A0A0B1P1A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gpi anchored serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003756">
        <property type="protein sequence ID" value="KHJ30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1A4"/>
    <dbReference type="STRING" id="52586.A0A0B1P1A4"/>
    <dbReference type="HOGENOM" id="CLU_1001824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079642" evidence="3">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="278" mass="30483" checksum="0FDC90044DAC6077" modified="2015-03-04" version="1">MYYFKVLSTALACIAAVKAQTKGFNPFLTPAAGQVIKAGKDFDILWQPSGVPNDATVSIKLLQGDTPTTMQLGPNVASRIPSKEGRFTWSVPNSITDYKVYGFIMYLDGKEDVFQYSFPFDIECLDNNENSPATPPVPKKGPSVKYIPGNAQSPNSPPKNPHDIKHDHDDHDDHDDHDDHDDKDDDDDDDDDDDDDDDDYHHHHAPKPVPSGVPYPDSKHNGTYSHGAPKPSTVYPPPAKPSTYTPSQKPKPEYTSGAKNLAISGFSLVGGITMVFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D3</accession>
    <name>A0A0B1P1D3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002385">
        <property type="protein sequence ID" value="KHJ32043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1D3"/>
    <dbReference type="HOGENOM" id="CLU_010246_4_0_1"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="273"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="60470" checksum="A0AF0A1E6C34852F" modified="2015-03-04" version="1">MKRTSTSQQAKSRANSPREKTSLNKIEIIKGDLKETQERKKFVLMPQSQRSRYLKTAGVLFLAVFLVYYLFRGEQNFHEATRITIGQTASAKTPQSTKCTKSFDESKPLIQFVLMIDAGSTGSRIHVYKFNNCGPIPDLEHEEFKMTDKKPGGSGLSSYKTNAEEAARSLDVLLDVALKSVPNELKSCTPIAVKATAGLRLLGPKISRDILSAVRARLESKYPFPVVSNEENGVAIMDGKDEGVYAWITTNYLLGKIGGKDKSSTAAVLDLGGGSTQIVYEPKFRLSENERFADGDHKYNLSFGSQNFELYQHSHLGYGLMSARESIHRTLIQDIYEANSTDHKWISQPIVNPCIAPGMNRQIEVKLSPSHKLGESVSVNMVGPTYPAPAQCRRLAEKILYKDAKCATTPCSFNGVYQPSLSASFSQGDIYTFSYFFDRINPLGMPESFTLNELLDLTNQVCGGESHWGIFASVPGALVELRGRPEHCLDLSFIMALLHIGYQIPLNREIKIAKKIKNNELGWCLGASLPLLNTGSGWQCRINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F1</accession>
    <name>A0A0B1P1F1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002075">
        <property type="protein sequence ID" value="KHJ32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F1"/>
    <dbReference type="HOGENOM" id="CLU_062858_0_0_1"/>
    <dbReference type="OMA" id="PSNLEIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36601" checksum="1F66E7B8534DC0DB" modified="2015-03-04" version="1">MTGADEKENKYQLTKLEQGFRNYKIVILISKATCGENLCLSMKKSIRTPYSGRSSKATSSTLCQKCLKKGHYSYECKAATQERPYVSRPSRTQQLLNPKLIPKLSNEVPHDLLRKKGIADEQLAKFDEERGRKRETHSREYHKGSNLKRTRSISSSSVSVSTISTRSSLSPEPLPVKAPKSQTSNDRSRLKESSSNTRRRSTTRTKMTTHQQSSHSVQKKRNREPSSDTTSPTPIEYRTSDRKSSRRRNQSIGSSPRDKMPRRKSPFKSQNPSNLEICGDSKGALASTNINSKEDKVKSPKREKSLSPFSKRIELTKAMNMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1N6</accession>
    <name>A0A0B1P1N6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002284">
        <property type="protein sequence ID" value="KHJ32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1N6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1N6"/>
    <dbReference type="HOGENOM" id="CLU_034955_1_0_1"/>
    <dbReference type="OMA" id="NVPDEGN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="46877" checksum="7367945C9D6B0345" modified="2015-03-04" version="1">MLIIQPFLTYYFLHYTQHVTCSAGSSQTSATDLNLSCSPMNSTDCYPRIFQPTLKFQKVRDGQELPPGLHVRMNIYTGEKEARLNIPMTEEDNTAGYDIQPVFKEMALTIFEEDDLHQKPMKNYASTKLTASQEKIPPPKSQSELQTFQNSIFILKTGGVSFDQALEDLSELAHDIYYGREIAREDLVLELLVCLTLGLERENTPNREINRERIAASILSSAFQNNPAAIKEISSVKRNIMYPSCISNSANEVKEKENFVSIFRSKLEQENDDHKLKSKISTISRLLKSESFRDLYLENEGMELLLAVFLKKGDNFNAVRKKIGELLIDNFLDESYGAEFNIWPKSQRSLKSFCEKHLNSVHDGCWEHHIEEFSAQVPAEDWPKKLLLALESRRPKKSPSKSEISHTVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P5</accession>
    <name>A0A0B1P1P5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative la domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003640">
        <property type="protein sequence ID" value="KHJ30781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1P5"/>
    <dbReference type="HOGENOM" id="CLU_043291_1_1_1"/>
    <dbReference type="OMA" id="WRIYEAN"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="125"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="277" mass="31393" checksum="B7334D1F57166943" modified="2015-03-04" version="1">MPADILKTTARVQVGVKNSKYDPSVLPITNDPIKIRAQVEFYFGDANLPTDKYLWGLTGGSSNIPVPIKKICEFGRMRRFSPYSSIVSALKESQFLKVSGEDGDELVERKEPYNPDLCPKTEEGRSIYAKGFGNEEPSSQFDIEAFFAPYGPINAVRLRRTNKKLFKGSVFVEFAEEELAEKFLNLQSKPLWKEKHELIVMSKKAYLDLKKEEENSKGKNSKTNDNRYKGRKRDRGRNSNRAYRVTKSSNNKGKSGCKVSDIDPDNLKKSQEEQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1R4</accession>
    <name>A0A0B1P1R4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003103">
        <property type="protein sequence ID" value="KHJ31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1R4"/>
    <dbReference type="HOGENOM" id="CLU_1344124_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="22623" checksum="7BEC10709D5DD1F0" modified="2015-03-04" version="1">MPNYGTIHRTAKPYSFSSSEGSPKSSNSTKTDSETPTNREASSVSLALESAFQTLVLQDQRSSIDRNLNEGVVFSDKMTDGMPSLPELTVESFDGTTAGARFLMALKLNLRNTDLETWPGLWIQAVYIKVKGEAAVWMDSTPHIAALVDTLETVTVAQKNNFDVEFKAQFPGAQIDPTRVPDHLELTTFRQRPDESLQAYEFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1V5</accession>
    <name>A0A0B1P1V5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1364</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003527">
        <property type="protein sequence ID" value="KHJ30861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P1V5"/>
    <dbReference type="HOGENOM" id="CLU_001128_3_1_1"/>
    <dbReference type="OMA" id="NDVMWKQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1514"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1796" mass="203187" checksum="95C826B9DB7D6F40" modified="2015-03-04" version="1">MATTLAAQLSTIAANSRNSLDLKAIKTRHSKSLIFEPCTAASQNFETIYTICYEGFQELCLLDSRFLEFQNDIFGVQSQELDRSQMTIAQNADLDERLKAFLYLISGRLRLSPAIKATEWLVRKFRIHENNISDTLQAFLPYHTLPIFTTLLSILPANLPDGYKFLGPYIRSLRNPPRNVIVHTAAINLSLSSALNIFILNMCKMQYQSYSHIVFWAGIMTEATALMLDRARSGRKAVQLQNEQEALLKILPTLKQGLSMKEVSSLRVGCFMILSVIVSKGDFDDKILSALMEAVVFGWTNDTAISSMICLSLLLEHRGSKKLPKKLMKQLIIDQNFLDTLIKISKQQRVDRLANVISLAIIDRLQNEGDSGGFLLIEKVIDNNLLSESQVIITGRNLIMIANQMVETNKTDTHLSKLIAKLIQLPGTVGPAIRSSLMEAKIDLDELELKLQLSIQPCMKVGLLTNNEFDSSKSIKSSKSCEVTEILEQLPEKENDCISFLSHKNSPIYYDLCNAFLSCITKSENLAKFDELPILQKSIAIEKPFYLSFYMRVWCSHGLASTRVSALRMATLYLAGQKNGIDFQALLPYAIVALSDASAKVRRGAAELLNTIGKLYSPITAIKTSKTCRSWCLENIYESSDTGGYNWLPIDVAARFVNEILVPAAEECVLDRNHIEVLIKLCLCSRDKENPEKANYGHLSQSSRKALMHFLSFQIRSSPIFNVKLKLLACVNQVQSIGSMNRTTFLLPILQNWVSLKTSQIQLQCQEEQLDISILEENFLNIIIAKSVEGIQFLQDIIQDYRIQKRPSLEVAIYKRMETLWKSLRRELQYDTAQALLAATECFRNNDENKMKITGGAADLLHKVPLSSEVLASFLNKVFIPGNSLEISPATKRRRTENGKIVTGQVQDPVLIKSIIRRLIFVLQLVDDSDLAKNPDLLKPLFNILAQLQDFKSVLASELAYIHCLNLGCILNILKADETKEKLIIKDSDIRADLLVDCVQKTSSPQVQNLALLIISSLASIVPKLILHSFMPIFTFMGSSILQHNDEYSLHVINQTINGVIPPLIDSFRQNSKDPIAGASELLLSFVAAYEHVPAHRRKRLYISLMKALGPKDFLFVFLAMLVEKYENSNDIREFSIEIFGAFNIEEKLQTAVNYIHLISDILKPEPNLSSIILNINDEIGKNATQTAQLELFALAYLLSQTEFVLQIEIVLSRDDINSSRVRDIYSTLVENLLAFFETVKESKMLCNACGEVLESTLGLLSTQEFLKSVQTLLGRPDKSLRRKILSSLQIRIENDKSFNGASANAILGFLPQLRVIIQESSDMQNKYVAINCVKKISIKYGRKDLEAMKGAAETISSSYCLGHSDNQLRMMAFQCLASIVDILKEEFIFALPMTIPRALEYLKKSMENKDKDEMLHNACYMFLSALVGHLPYMISGAHLDKLLELSNISAEAMLGDETRKIRVNFVSLAVKLVDPKHVFSSLERYFSHAMSLGPLVFREYMNYLRISITHHSNEFFNKNSVIFAKIVQNALDLKRRLNLVNDDRFTKNVIDEFENILNYVILEIVYKLNNASFKPLFIDLVDWATVRLEKEDRVGRSLRQQSLYSFTALFFDSLKSIVTSYASYLIESSVEVLTSIDLNDEISKELWIRVLRTLIKCFEHDQDDFWQTPIHFKKIAPVLCAQFASAKVLPISQELIPAIVELASVVDSPDHHKQLNISMLKHMRSENASVRLAAVTCEQKLTERLGEEWLSMLPEMLPVISELQEDDDEVVERETHRWIIKIEEVLGESLDSMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W0</accession>
    <name>A0A0B1P1W0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01003496">
        <property type="protein sequence ID" value="KHJ30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1W0"/>
    <dbReference type="HOGENOM" id="CLU_049327_0_0_1"/>
    <dbReference type="OMA" id="TRCILVY"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="148"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="39537" checksum="57701FA617682F9A" modified="2015-03-04" version="1">MRVQVRGPEGASTLTLPEEATLADLIENISIFTGLSSFDVKYGYPLRSLNLNQRDVSQKLSKFDFKIERELLTVCSRTSDITEQSDVKINPVQPKNEIQAKSDFNLSSTVEPSTTSKSYTSSFNSVPTDRERRDEVPEVPMPHRGATVVLRIMPDDNSCLFRAFGSAVLPGDDKSMPELRSLVASVIQFEHETYTKAVLEKSPDDYCRWIQTPNAWGGAIELGILAKHFDIEICSVDVETLRIDKYNEGQPTRCILVYSGIHYDTIALSPLDTQSYNSQSPPELDQRVWDSRDTEILDSAVKLCGILRAKHYYTNTVTMKIKCKVCNMMLHGEKQAAKHAQQSGHYDMEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P268</accession>
    <name>A0A0B1P268_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002903">
        <property type="protein sequence ID" value="KHJ31420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P268"/>
    <dbReference type="HOGENOM" id="CLU_2160282_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="13585" checksum="90A9FCDB9F5155E6" modified="2015-03-04" version="1">MGKEMQDIETKRKILESEKQSLENEWKSLKSERQNLEEEKLALEADKKNLEIERQELKVQMQDLENEGKYIQIEWRELEYERKCLDNEWLEVERERQLLESEMLKKLTGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P288</accession>
    <name>A0A0B1P288_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002115">
        <property type="protein sequence ID" value="KHJ32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P288"/>
    <dbReference type="STRING" id="52586.A0A0B1P288"/>
    <dbReference type="HOGENOM" id="CLU_051875_1_0_1"/>
    <dbReference type="OMA" id="TEYNFYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="300" mass="34351" checksum="4F6F2C1256CFE576" modified="2015-03-04" version="1">MESKVHRADLHTPPPVALSCLKSENELIQRLTTIYGPITTYSTSRRLADVATSGTSLVPSTTCQKPPLLKNDCSAVSKTTKELVASETEYNFYLFRNSRESSPQKVILEQEQLHLLDDGLNDKQGGFLVSQRKISYYFTPPASKGYKEQLVLSAVEGETVKQWSTQRAWGLEVPWRVQILRTQISAYKEVPKAYSNNGQENINVSIESNTPTSSEILQAQFQTQESCKSNKRRKPSKKRRIAVRKKLRAILALEEQQMQMKELKAQALKEKKIRRNREKKIKRKIKKKKEKEVLVDTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C4</accession>
    <name>A0A0B1P2C4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001805">
        <property type="protein sequence ID" value="KHJ32807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C4"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="215" mass="23710" checksum="EF22C26407731E42" modified="2015-03-04" version="1">MICTTIEKEVVASKPYLQQAIVKFADADSSTSPPLPQAPTHTRLNKGNGKGNDKNLTKKIAVATPQIVPSKAVNMRTNKEVDIPKIPQINDNTWAIVAHKDQKKTRVVNCNKTQVSGGNKNVSRVFNKENSSRSVLDKKLFVHLLQEHEWRKSSPAGIREVMVKKLAILPTLTEKIKPVHSWFAPSPCSTEARDKIFNAGNGLFLLGAKLEAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2J6</accession>
    <name>A0A0B1P2J6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002785">
        <property type="protein sequence ID" value="KHJ31560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2J6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2J6"/>
    <dbReference type="HOGENOM" id="CLU_053582_0_0_1"/>
    <dbReference type="OMA" id="CINGPHT"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="42009" checksum="55BD749B2963353B" modified="2015-03-04" version="1">MNLSSLVHAGRTQAEQQQQNLHNHHHHYYQPHQQEPQSSSTTTSLISPYMAHNDSNKSKYPCINGPHTPPSPLADESPKCSLPSISSLLVLVDSSSPQGQSQYTQPYSYNTEFAGSKLAPGQAHQNNYFDMGNQKCGSSPPINSRGIFPLTPPLNSDPGFDGRQSSPSVISNSDNSVSSVSNYELASNLSTEFSLKNHTESPDLRRRAPSFENKYSLSTQIRPRSQSSLPASDNHYQASHHRLSPFHPKSIQQSQSSSLETSGLPYQRPLPQQFSPSSMQIPTPNSTPNSTPIPQFSPANPWQHHHYISPSSTASFPQTQDRYICQTCNKAFSRPSSLRIHSHSHTGAKPFKCPHVGCGKAFSVRSNMKRHERGCHSSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M1</accession>
    <name>A0A0B1P2M1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0661</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001720">
        <property type="protein sequence ID" value="KHJ32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2M1"/>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OMA" id="PHQTIYR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="165" mass="17839" checksum="2A5D2235F4E0AFE8" modified="2015-03-04" version="1">MQSLRCVRIALKSRTTVVPFPSQRRYYAEAVADKIKLSLALPHQSIFKSQDVVQVNIPTVTGEMGVLAKHVPSIEQLKPGLVEVIEESGGSKKFFLSGGFAVIQPDSQLSINAVEGYSLEDFSIENVRSLLAVAQKNASGAEGEQGVAEAKIEVEVLESLQSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M3</accession>
    <name>A0A0B1P2M3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002755">
        <property type="protein sequence ID" value="KHJ31585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M3"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="35223" checksum="9615ED35ABCC9329" modified="2015-03-04" version="1">MADSMEISTESQAPSTDTSKQPPIPSVPPIHNSPIIIASPPPPSNLTPSNTSLAGRQILKPVTPSKRPVPEISIQNSTNNSDAANAFLPKELAEIVANRQHSTLANITDDIEKEEAFALKAYLQLAIANFAAVDTSPAPPQIPSYSRPTKFSGHGSGKYKTTTNEVTVAIPRTIKGAVTSEENTQQAHKLPKPPQLNERTWATVARNGQKKARVTLSMKTQAVPTSKATQRVTNKRNSITTAPTDQILFVRIPQEHEWRKLSPAGIREIIVQKLSISPSLIGKIKPVHSLRVCLKPLQYRSTAGYFGCREWPISVRSKTRTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P324</accession>
    <name>A0A0B1P324_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative c2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001882">
        <property type="protein sequence ID" value="KHJ32683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P324"/>
    <dbReference type="STRING" id="52586.A0A0B1P324"/>
    <dbReference type="HOGENOM" id="CLU_022666_2_0_1"/>
    <dbReference type="OMA" id="SRYNFQA"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="57930" checksum="454552904DB99DA0" modified="2015-03-04" version="1">MASKTNTNIIEIPPAGGYDATPIPSAPDGYTIKFTIHRAENLPRSDLTTKFSDPYVIATLKSDLPRRHDSDPDMEIRTPTIHNSVNPQWETQWIVAGIPSTGFKLKCRIYDEDQADRDDRLGNVTLLVDRVKTGWPGIKYNSFTIKKRVGSKRAYILHGCTAIMDQNINFDGFLFLSAELIGKSEKPYGRMYTIGPAFYFKHYSPLIGLLAGTKVPKDSKNYGKDHIEKYDFQANQLQLEGPVPAELYHRFVEFRPFVKGLFDKTGIRGHILNIVLHHQHRRIYNYSSTTEYGIFKPCSEEASMQFLTMVHFDDGWRTFTYVLTLDGLLRFTETGKEFGIDLLSKHTMHSDVSVYIACSGEFLIRRRHHHSTQESQKTDSRSSDSSRDLKNFTLIIDNDSGTYRPKSDLLPLLKRFLNKNFPGLHIQIKDCMDKDHIEMKKEQRERKKLNGYQVQMVLDSDGEIDSSDEENLVKRYNGGDGKRERIYAALEDPKKAIKEIIEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P397</accession>
    <name>A0A0B1P397_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002935">
        <property type="protein sequence ID" value="KHJ31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P397"/>
    <dbReference type="HOGENOM" id="CLU_1078462_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29410" checksum="C4C869945C5364DA" modified="2015-03-04" version="1">MKGGPILDSTSYNRWCTHFSDVLSIFKLENYLTTEMIELKTRNTKDIPENHLIVHKQDKYIRIAISQLVSDVVFHLVNSSYTSEECWDNLRQFYRPNSAQDVDDLLLEFWSFVVEDDIEVDDFVQKLAEIRGRINLIDERSAPAESSMNKRILGHFIKCYGGFYMSTVASLRDSNVSFQSVVSSIRASHSIHEELHPTSVVALATKVRKSSSTPSPANVKTCVHCGRRGHLPEGCFLWLDTPDGSRWEAKNPKAAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D9</accession>
    <name>A0A0B1P3D9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002556">
        <property type="protein sequence ID" value="KHJ31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D9"/>
    <dbReference type="STRING" id="52586.A0A0B1P3D9"/>
    <dbReference type="HOGENOM" id="CLU_021695_3_1_1"/>
    <dbReference type="OMA" id="HQYLEFQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="55226" checksum="3C0B41A3551E3BA6" modified="2015-03-04" version="1">MDILSETTWDVLISGTDIQRSLLSLALSRSKKKILHVDANPYYGGINAALSLEEVDEWAAKHKGTGNDIFQNAQIQKPSTSDDIARLSPSRSYNLTLLPFIIHSNSKLLSKLISSNAYRQLEFQAVGNWWILDSFQGRETLKKIPNCREDIFQDSTIDNRSKRNLMKFLRFVIDYKNQPDLWKSFSEKPLNEFLSAQFSLSVNLQEAIAGLTLTLLTPNLTTVSWALPRIHRHLSSIGVLGSGFGAVISKWGCGAEICQIACRSGAVGGCVYILGTGIEKQNQANENSELLKIKLTNGVVIETRHLAAIPDESIKANSLSISRLISISTSTFNNMIKTNTEGGPMPAVFIVVFPPGSLNDRSEISNQYPVYLMVHSSDTGECPEGQYVIHATTVTSEKSKDILETSLTRLIKDADNSDGNIIYSFYFEFFPSREVTSPHFDSIEQPIDLTFNEHIIDYVEYDWQKVMSCDSESETFMKFDDRDTTSPNDEEEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3H2</accession>
    <name>A0A0B1P3H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002518">
        <property type="protein sequence ID" value="KHJ31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3H2"/>
    <dbReference type="HOGENOM" id="CLU_1332789_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="206" mass="22389" checksum="33EEF446B94EFF93" modified="2015-03-04" version="1">MELNHNTDPFEYQIFETNVSATRSGRRESGATTKDTATNAEIAQVNFKQTPKRLDFPCRDPVKDSKNWNNGITPGNCGGSGGNGGRGKASLDTGAARTYKKLLTEATQLIESFQKPKVSPTPGFPILKFQTTSSSNDSFSIAKILQDVKITKAAVTQVPVTVHGKSWANVASKSQASETIIRIHDEEEKKEISKLTSEELAKKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J7</accession>
    <name>A0A0B1P3J7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the rad9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002489">
        <property type="protein sequence ID" value="KHJ31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J7"/>
    <dbReference type="STRING" id="52586.A0A0B1P3J7"/>
    <dbReference type="HOGENOM" id="CLU_030657_1_0_1"/>
    <dbReference type="OMA" id="NETQCRF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="51175" checksum="A1C29E9DB05689C3" modified="2015-03-04" version="1">MIILKFSLNPDALSKFYDLLICLGKFSEYVSIEVSEQKLVLTTLNSTNSAYASFTLSASKYFSRYDYKPVRTEKGLKEKFNLKIFNRALVSVFKGRTIDQNKEKETAVEKCDAYIDDDEEGGSQSRFVIEITCRHGVCKIYKLTFESHPSMHAIFDTENASNCWSISSKVLREFTDHFGPGTEQLDIYLEDGRVNFTSFTEKILLGNEILKKPLHTTIAMDTLEFSQFTVEESLHIVINVKDFKAIIAHCGILNVTVNVSYSQPSSPMQLTYDLDGISSKFILMTVGGSSFMSTLNQKQKGLKGTFSRQSQGTKTFSQKKSSPKNFIPKDRPLEAHIDERLTQPKILKLPPAPQSSVQSESLFIPEDDNDRKWEPLKFDEDEEMLLWDASEKDLTAFDNGKRFSVSLTNDQSGSSRYDLVKNHEDHSNEIASQGVPPTQKLSQIINLGIFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V3</accession>
    <name>A0A0B1P3V3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003002">
        <property type="protein sequence ID" value="KHJ31314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3V3"/>
    <dbReference type="HOGENOM" id="CLU_090424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="29262" checksum="431727011A644433" modified="2015-03-04" version="1">MPSKSGRLHPSLLSIANAMQQLETEKRERMGLAQESLEIIDAWAKGKTGTKAEAIIVPLIQKIAPTVTAFATGAVEDALLVPTSTHKAKNFQILTRKSAKLPQPSLSAIPLPKKPDGNKKETESNDPKEDKRLFLRLRPDHAWRKLSPIAIKKMNTEIAGVTATAITSLYSVRSGYAIECVSDALRDTVFTAGKSLGDTDAIIEAASDLTSLLLPNVPLSIRTLDSNVIVTSEMVANECLAVCGMLPIQLRPMKSSTGQFYTSWLIHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P403</accession>
    <name>A0A0B1P403_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001454">
        <property type="protein sequence ID" value="KHJ33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P403"/>
    <dbReference type="STRING" id="52586.A0A0B1P403"/>
    <dbReference type="HOGENOM" id="CLU_633395_0_0_1"/>
    <dbReference type="OMA" id="PRINTNE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="433" mass="48553" checksum="E75BD58385E8347D" modified="2015-03-04" version="1">MTTTPFRELPPPLAMTLSHSSEKSRSVLGQSQLSQSMGHLPDIPLQWQESEDTMGNWLLAKAEEDKLRQEEEKTRQEALKLEQRKVEQDMLNTSLREGIPPFLIPMFFAGISGGSSPTTCTEMFQNQLAQVHQQQQQHQNSLQKSQLSAQAPITTNQLYQTDTRSNQLYQTDTRSNQQYTGSVLRPLTSNSCSKQMTINGSHLCPKVAKSYQISPASTPRSYQMSQSKAVKLSRLSGEGINFDSIVTASGIQNTSEKQSSPPIHFHYWQPPTTQTEKCCVHQSTNSLGKCKTSSIFTLFQPSSDNDSPPKKRKTLKNQLPAPLPTHQQQQQQQRYSTNFSKLNTSILNPPITRQPSNTKQIGYSLGRELSDYSEPINNQCNIEKSSHEKISSLPNQAKTSTSKKTQLDSLVQSSHSVSNLLEILEPTRENCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P441</accession>
    <name>A0A0B1P441_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001421">
        <property type="protein sequence ID" value="KHJ33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P441"/>
    <dbReference type="HOGENOM" id="CLU_1876975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="136" mass="15058" checksum="41FA0E371DD7947C" modified="2015-03-04" version="1">MSVFRVPSPTDSAHSRTSISLNYHSVKSFDLIQTPYITHKDAMSHPPPPFLPGHPVPANQGTDNTATIVTLSLTDDQLSRLLSIINVNEAPVQKCRSDSSSKKIKPSSWPEWDGSKELYPTFIVQLAAKVDTDWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P470</accession>
    <name>A0A0B1P470_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="JNVN01002315">
        <property type="protein sequence ID" value="KHJ32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P470"/>
    <dbReference type="STRING" id="52586.A0A0B1P470"/>
    <dbReference type="HOGENOM" id="CLU_035382_3_0_1"/>
    <dbReference type="OMA" id="PERYGIH"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="433" mass="49587" checksum="DF1A5DFB04A3ACF3" modified="2015-03-04" version="1">MKKLTGPLNPRPQYHKLVGDFLCGVHPWSHNAASIILLADALLCCLIIFKVSYTEIDWTAYMEQIEMVVRGERDYTKIKGGTGPLVYPAAHVYIYWILYQTTSQGKNILLAQVLFGFLYVATITIVMACYKQAKAPVYIFPMLVLSKRLHSIFLLRLFNDCFAVFFLWVAIYLFQRKRHTLASLAYSLGLGIKMSLLLPFPAIGVILFLTKGVLGSLIQIWLIIQLQLILAIPFISSNAIGYFNKAFEFSRTFNFKWTVNWRFLGEKIFLDRKFSIALLIGHLCTVVTFALSRWLRPNQEPVRGVIRNLLKLQVSFGKSQSAISSRADPNFILTTILSANAIGFLFARSLHYQFFAYIALGSPFLFWRAGLHPTLQYFLWALQEWAWNVYPSTHLSSTVVVSIQFFILVSIWWSTRKDLNCLRNDTLALKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4C4</accession>
    <name>A0A0B1P4C4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001610">
        <property type="protein sequence ID" value="KHJ33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4C4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4C4"/>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="OMA" id="DIQAGHF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="119"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="457"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="708" mass="80879" checksum="44A6F35B6A8994DA" modified="2015-03-04" version="1">MAALSKLSLQSTNRTLKLLISELSIHYLRHRTKISRTIYFTLFLALLNRIHAAVSEQKEAALSQLSLQRGSVIHGSNVPNKRPKVELNREFFRNLFRLLKICVPGWRSKELRLLINHSLLLLIRTLISLKVAAMDGALVSCLIRGKGRDFLLGIIWWMLIAIPATITNSMLSYHQCKLSLQYRTRLTNHIHDKYLSNMTFYSLSALDDRIKNTDQLITVDVSNFSKSLAELYGNLAKPTLDMLIYTYILSKNVGGEGLFFMSLLVQLSANLMRALTPPFGKYVADEARLEGEFRFEHSRIVDYGEEIALYNGHEVEKDTLDKGYFTLIKHVNYILRRRFTHGFMEDFIIKYIWGALGLVLCSVPVFFKIPLSSTQTMGDRTESFVTNRRLLLSSSDAFGRVMFSYKEITELAGYTSRVATLLKVMSDIKSGHFEKTLVSDSNSDEILNLIKKRGEVIEADDIEFTDVPIITPGGSILIQALSFTMKPGTHLLVLGPNGCGKSSLFRILGGLWPVYGGKVRKPPLSQVFYVPQRPYLSAGTLRQQIIYPDSHLDMRRKGITDADLLNIMSILDLNHLVENFVQGWDTEAEWRDILSVGLQQRVAMARLFYNRPKYAILDECTSSVTIEMEKIIYDHVKALGITLMTVSHRRSLWKYHSKLLQFDGQGSYVFTQLDAEKRLQLEDEKDELEMRLRQVPEIERRIAELKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4J6</accession>
    <name>A0A0B1P4J6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001572">
        <property type="protein sequence ID" value="KHJ33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4J6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4J6"/>
    <dbReference type="HOGENOM" id="CLU_012334_4_1_1"/>
    <dbReference type="OMA" id="VHTHKKD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="526" mass="59269" checksum="81DE65BBF218AF52" modified="2015-03-04" version="1">MVSLPSLRQTSLTSRKLSVDDSNFDGADDETTVMEPDQGNVLTHIISQLRPGADLSRVVLPTFILEPRSMLERITNFMAHPELLLPLPQIEDPIQRFISVVRFYMSGWHIKPPGVKKPLNPILGETFSCYWQFSDNTKGYYISEQTSHHPPKSSYFYMIPEHYIRIDGCLKPRSKFLGNSAASLMEGIAVLRFLNRGGSFKKESYIVTQPNMYARGIIFGKLKFELGDHSFVRCPEHGLSADIEFKTKGYFGGAYNNIGGSIKNDRTGEILYELSGSWSGEMKIKDSKTGKKEVLFNATKAKHTPPLVRPIEEQGERESNRLWLKTAQAIRERNHELATYEKSKIEDMQRDEAAKRIEDGVKWHPHLFRPVQAEPGGSEEGLEDLDWILNTNIDGPTPQSQVDQILAVAPILPGQKKNHTTSALQQINQLGTCSPPMINSFTKENSLPSLINIKSGDTNEHQAFNGSQTHKDALVNFQGNKLETRQEPLLGFHREMTKGLEIRQDSSLREADTDTSSLDEFVDAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4L4</accession>
    <name>A0A0B1P4L4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bar domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002540">
        <property type="protein sequence ID" value="KHJ31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4L4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4L4"/>
    <dbReference type="HOGENOM" id="CLU_059017_0_0_1"/>
    <dbReference type="OMA" id="NIMFATR"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="35605" checksum="A1B79EA76C936B36" modified="2015-03-04" version="1">MNKLSAFGRNVSASFTPFAARTQQYMKEQLGQVEDKTQLPPDYIELEKKVDALKQVHQKMLQVTSQFANEAYDYPANIKESFGDLSRTVSEKVQLLSYATSTAEAQAALTAPSSSKPQPKTFNHAIARASLASSQLLAEQQSSSREDPLATALEKYALANERIGEARLAQDSQIQSRFLAAWSTTLNTTLNFASRARRNVENSRLMLDAVKAKAKNTGWVLPGQTQKPPGIRDDEITSEEARLEIEQAEDEFVGQTEEAVGVMKNVLDTPEPLRNLFDLVTAQLEYHKKAYDILSELTPVIEALQVEQEASYRKSRDTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4X7</accession>
    <name>A0A0B1P4X7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001526">
        <property type="protein sequence ID" value="KHJ33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4X7"/>
    <dbReference type="HOGENOM" id="CLU_2777775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="69" mass="7371" checksum="0A12931DDC4012D7" modified="2015-03-04" version="1">MAGRGRGRGSAGGLKGATWDYDPTLKLDAKPTDLYPKASASDCDRKLASKTFQEASRANASWSTLHTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Y1</accession>
    <name>A0A0B1P4Y1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002114">
        <property type="protein sequence ID" value="KHJ32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Y1"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="34145" checksum="5324EBE7CBA6CBD3" modified="2015-03-04" version="1">MTDSMEISTESQAPSTDTSNQPPPISNLPPIHNPPSPIASSPSASETQVSKLSIVGRPILKPTAPSKRPTTGKIPQDHSETTDMENAFLPKELAEVIATRQRRERAWHVRVMICTTVLSNIDSTLASLTEGIEKEEAEAFKAYLRVTISDFAAAESSPSPPSVPMHTRPIKSNGKGKGKETVNNLPKKVAIVTPRIILSQATNRGINKEAKLPITPLSRDNSWGAVARNSQKKARVTLNNNAQAASSWKATQSLSSKHKPTKAALTDKRLFVRLPLEHEWRKLSPLGIREVIVNKLAISPSLFGKIKPVKSGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P501</accession>
    <name>A0A0B1P501_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002396">
        <property type="protein sequence ID" value="KHJ32026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P501"/>
    <dbReference type="STRING" id="52586.A0A0B1P501"/>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="235" mass="26920" checksum="C9B19BA0A54B802A" modified="2015-03-04" version="1">MKLPANGSQKLIEIDDERKLRVFMDKRMGAEVPGDSVSDEFKGYIFRITGGNDKQGFPMKQGVMHPTRVRLLLSDGHSCYRPRRTGERKRKSVRGCIVAMDLSVLALSIVKQGENDIPGLTDTVHPKRLGPKRATKIRKFFGLIKEDDVRKYVIRREVQPKGEGKKPYTKAPKIQRLITPQRLQHKRHRIALKRRNAERTKDAANEYAALLAKRIAEAKAQKADLRKRRASSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P540</accession>
    <name>A0A0B1P540_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative multisynthetase complex auxiliary component p43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002063">
        <property type="protein sequence ID" value="KHJ32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P540"/>
    <dbReference type="STRING" id="52586.A0A0B1P540"/>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="OMA" id="QVCRTVC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="213"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="45593" checksum="D49C073ADB8EACF9" modified="2015-03-04" version="1">MSAFTSVPYSNAESTEIKQWLTTCERLKSISGEDQNLLLSTLNNHLASRTTLLGTKPSEADVALYHSLASLVSSWTVEQRTGEKGYPNIVRHFDFVQNSPKFHLSIRDKDKITVDPDEICYIPPSVDAKAEKERIKKEKTKIKSATDGKISELVDRTLNKTKDGRKNNKELNNLNSELKDGLSKEIPENTQNQKKKEKISKPIKKPAPTVSLSVSLIDLRVGHILKAIKHPEADSLYVSTISMGDKPGTDDTSEYEGQVVRTVCSGLSGLIPLEEMQGRKVVVVCNLKPVKMRGIKSAAMVLAASPRPKDGEDDNHSKLVELVSPPEDAKAGEKVFFEGWKGEPEKVLNPKKKIWETFQPGFTTTNDFEVGFQAALIPSLVTNTTEPTQRIAKLVTESGGICKVKTLADAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P593</accession>
    <name>A0A0B1P593_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002015">
        <property type="protein sequence ID" value="KHJ32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P593"/>
    <dbReference type="STRING" id="52586.A0A0B1P593"/>
    <dbReference type="HOGENOM" id="CLU_294955_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114737" checksum="F8FA702E44132C76" modified="2015-03-04" version="1">MSLTVLPAYSLRVQLFSSAACGATDKPVRNFRVVTSPENTIREFCQEASRIHEINYGHPLVIKKVQDDQSFDVTQSEILGNLFSTSSIIRVVQASKHPGIRDSIPPTSALRFNPNKAQKRRRYPDTIVSDTENLWKSIKRQKLNVIDPDCPLPSRESDGASPSNHLSHAQIIGALKKSELAKKPNHKNSNCQISETPEPVATGWQNFRALEARSIETQIHSKPDFDEQQNRYRQRTNGGLYLVEPDRTSPKIPSQQVRKVHNKGSSVSSARSSISLGQSYIKDDFVLSSKFSKAPIPLEARDNVELDSAECRLKKRRKKKKCFGEDQRTQVINRSIPGTHKYDKNQLKTVLAPKKFNERLDTKISHEANSPNITQNISRLQDEHISKIKSGDLECSPHAGKAEHHINLKEKSFSSAEISKEVQDVQNKQKKKKKKRKKKKEATLKNESQSNYLVGDTYNGQGKKSNRGLEASEQNFDLPVTISEKIQPIENKLIENHIISNTILNCENIHQKPEVSTEKSNVTTNSNSNSPSAQNQTARILKYSPITLPHLERKQDSPIKTLHDENSSPSKTSNKKRKTSHDHFGHAMPSSDKKLPVNEEENKYMSSTFSEKFLPNTDTLSQPESTSSKPSKTTQFKSRLPNNANISFQKKSFTPILPPPKNIDLFNIPVARDDKKILVTGTNAASATKIIPLKITPIVPNKRYQLPKSNLSKPNLPITTSSLTESKSTELSSKVQGQNQINPEEENKLFGKKDRDTLASTNHNVEILLNKENKQGAYSNSISNNLKEPNITEDDKVVNDESSQGETHSQNSSDRDSRSPVEFHQNFQPKNSHQTSSLSSSTHSEDENSEIDQISSSALDDSDNLEITEAGNTPDNKEKALDDSNITIRPRVSSDNKLDFEHQKFRPSSSHSMFKIQVPNSSPALQRTTLSNHLTSTNMSESSLKESNDNTSNSFISGSAVVPSSLEMKKPQFKFGASLSELHRNGGLINLSQTNHRSNEQNLLAMSLATETLSESESEESDTSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G0</accession>
    <name>A0A0B1P5G0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative duf221 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002277">
        <property type="protein sequence ID" value="KHJ32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G0"/>
    <dbReference type="HOGENOM" id="CLU_002458_2_0_1"/>
    <dbReference type="OMA" id="FVQFNHQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="851"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="920"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="41"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="593"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="714"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1251" mass="142192" checksum="DE2420EA0DB08472" modified="2015-03-04" version="1">MITGQVKTNRKMSDNNISTNSFPTNGPIPNAQSQQGISLVAFFSALTISLVVFAVQLLAFLLLRNKLARIFKPKTYLVPENERTDPPPRSPWGWLFALFKFKDQEIIRKCGLDAYFFSRYLKTLLVVFIPLAVILIPILLPLNYIGGRGSYYKQKLVIGIHNGIINETLAANITGLDTLAWGNVRPSQTDRYWAHLILAILVIIWVCGVFFCELRIYIRVRQDHLTSPEHRLRASATTVLVSAIPRKWLTEEALTRMFEVFPGGVRNVWINRNYDKLLKKIQERQYIFGLLESSQTQLIRLAKKAQMVQAEKDEKKKARISTYNVKMTRKDKQEKLRQADVQAEHLAKSGGHSTGDLPRTLTDALVEVECKANRSPLHSPIRSLHLHTLSSVSQGIGKGLDSFGRASETVIGGARYVGRNLEQHLEGNNGFMDIQDSPLGDQDYDRYGRFVGKKIIEPRDVEESQEVSENRESEQSTEPDVEVDLGTARHLKPYRGVHNSHKIKSSNAWWEFWKPPPTRFSTPTPAGYKSEENLSSSSRSRTKEFSLESENKHDVTERNIWTVLFPFLDFEKNKSNEYPIAHNVNYEESSEGAAWQKYLKAKDRPTHLVPLFSWTPRWLPGIPIINKKVDTIYWCRKELARLNLEIEIDQKHPEKFPLMNSAFIQFNHQVAAHMACQSVSYHVPKQMAPRIVEVSPKDVLWDNMSVKWWEAWLRTTIISGIVVAMVILWASPVAWTASLAQVSTLASRFPFLRWLEDIPNNIVQAVSGVLPAVILGVLLLLVPIILEYLAFLQGAQTGTEQQSSLQIYYFVFLFVQVFLVVSISGGTVAALGTATNITTIPDTLATQLPKAANYFFSYMILQALSSSSGGLLQVPTLLRWYIWPRLVDSTARDKWTRNTTLPSITWGTLFPVYTNFACIALIYSVIAPVIIIFAIITFSLLWIAQRYNMLYVFRFHLDTGGLLYPRAINQTFTGLYVMELCLIGLFFLVQDEQGTQACVPQAIIMITFLVLTVAYQFLLNKSFGPLLHHLPITFENEAVLRDREFEISQAKRLGLHFDEDLENSFAQNDEATQVNKPSRSKSKMNLCSTKTVQSTGGWALRSGKNITCKVLGQCVDHDDGSEENSALNERIRAREIKNHGRRKRRRDLEAQRRIADALYGGYNDDIEDLTPEERDVLVRRAFQHSALRARRPTIWIPRDDIGVSDDEIRRTREFAGNSIWISNVGAALDGKARVVYGRNPPDFSEVDLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G1</accession>
    <name>A0A0B1P5G1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oleate-induced peroxisomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G1"/>
    <dbReference type="HOGENOM" id="CLU_105945_0_2_1"/>
    <dbReference type="OMA" id="WTIDMKK"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="127" mass="13843" checksum="6F82C1A492FB48CE" modified="2015-03-04" version="1">MSLKNDAFPSSVAFDDINNALKASESERKQAIKQANAIFAFKLTNASGEEQSWHIDLKKDGEVRKGLGTKPTVTLSLSEEDFGKLIAGKANPQRMFMSGRLRVSGDIMKANAMQSILKKAQAPKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J4</accession>
    <name>A0A0B1P5J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcription regulator bdf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001133">
        <property type="protein sequence ID" value="KHJ33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5J4"/>
    <dbReference type="HOGENOM" id="CLU_001499_2_0_1"/>
    <dbReference type="OMA" id="MAHGGMM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
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    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="226"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="428"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="630"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="398"/>
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        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
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            <begin position="605"/>
            <end position="623"/>
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        <location>
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            <end position="748"/>
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        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="802" mass="89692" checksum="D70BC014CC71D8F8" modified="2015-03-04" version="1">MSIDTVSASATTEAFIEPSNTKTDQETKEELIDDIDNTANGILDDDLSSKQTDADVSQNVEQTSGALMELSDFFNENSESNAQTKALGSHKSSDQDTDHSIFQQSSDETKAKSQISSEFPPERESMEEIEQDSDAPQEHKNYEGIEPSPKVPRERECDEDIEPSAKRLKTENASKSLQANNSPKSNGNKFGRENGSVTPFDEKTKQNETITAYQIKEITKILRNISRTNAGKNFRQPVAVLWPSIAENYAAKISNPMDLSTIEKKLKEEAYTTMNDLKADVHLIYNNSVIFNSAENQVSKFAMETRNTLFSKFSSIPPEPIPPPKKEKKVVKRTAQTSDLAIRPPPKRTSRESQVIAQSTAQAFALDPTTNTPLIRRDSTKIDGGRPKREIHPPKNKDLPYAVRPKNKKHLLELRFCDEVLSELQKSRYSSINHPFLVPVDPVALGIPNYFAIIKKPMDISTVARKLRDGVYLNANEFEKDVRQIFINCYKFNPEGNPVRQMGKSFEEIFNNFWAKKEQYIIDNSPSAPSPSDRDSDEDSEEDDALDGSSAAASLMSQKERLLEEQSKLITLMGAKHKDEGLLQMQTDLVELIQKRVKAAEEHAKKKVNSKKKVTKSAKKSAPIKKAAPAKKAATKKKYLGTLEKETISAGLGLIPTQVMATVVEMIKTERPELADAGDETMELDIDSISEGILWQIHAMIMKHVPHLEGQIRESMSSEPRQPARSAKPAPKRKNKPMSKHEQERKIEALTNLDSEFARATFGSQDHTMQGLPNYASSPHLEMNTALEPESSGDEESDSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M9</accession>
    <name>A0A0B1P5M9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001112">
        <property type="protein sequence ID" value="KHJ33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5M9"/>
    <dbReference type="HOGENOM" id="CLU_1983221_0_0_1"/>
    <dbReference type="OMA" id="SEEPYHY"/>
    <dbReference type="OrthoDB" id="10378585at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061887" evidence="2">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="126" mass="12663" checksum="891759535917FDA1" modified="2015-03-04" version="1">MQLCNVPLVLFGLLCFGLVSTAPAPNSPWHLRSRQEGGGYYGQPSNGDGSVYPPSSGTGGFLSPTATSGYPSATGTGGYSSPSGTGGYPSATGTGGYASPTGTSYPTPTGGYSEEPYHYKGVKLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q6</accession>
    <name>A0A0B1P5Q6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001335">
        <property type="protein sequence ID" value="KHJ33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ELEFSFM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="24298" checksum="F8B8736463EF1608" modified="2015-03-04" version="1">MGPADDSSSAARDSILGINIEDLNLPKSVVTRLAKGALPANTQIQSNAANEIAAASDRKTVNANDVFTALDESEFSGWRPRLEAELKKHTEIIEQRKEKVRLKEIDGAPAAKKMKRAPVKPVDDANSYKSDPVDINLTSSKSNGFLSSTNAELDGSEKEDDESKDESEKEDHDKEDDDEDEGEDDEDDEDDEAVPIEEQEQEEEEETDNSDEALDNGEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q8</accession>
    <name>A0A0B1P5Q8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transporter sec9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001094">
        <property type="protein sequence ID" value="KHJ34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Q8"/>
    <dbReference type="HOGENOM" id="CLU_020823_2_0_1"/>
    <dbReference type="OMA" id="TNQRMER"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="340"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="44027" checksum="879FFD8763AD4284" modified="2015-03-04" version="1">MKKFGFGKKADKNASTASSAPPISNPYAQPKAGSDPYIQDGNNSGPSPNYAMRQAAGLPNGPGGSRGGGPNTNAGYGADRYGSGAGYGANRYDTQSNRNDLGGYGGMGTRNDNDMRGTEENRDALFGGAKDRYAQKGSLGTARSGGGYAADSSGNGARYGGGYGEDRQLTQEEEEEEEIAATKQEIRLMKQEDVSSTQRALAIAAQAEETGRATLSRLGAQSERLYNTEKNLDLVANSNRKAEEKAKELKTLNRSMFAVHVSNPFTNSSRRAARDEEIQTKHQQEREQREATRQAAFNSRNRLEGSMREIEDGSTGYRPQPKVSLAERSRYQFEADSEDEEMENQIDRNLDALGQAAGRLNALARATGKEVEEQNKHIDRIMVKSDRVDNQINMNRARLDRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T2</accession>
    <name>A0A0B1P5T2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001314">
        <property type="protein sequence ID" value="KHJ33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5T2"/>
    <dbReference type="HOGENOM" id="CLU_1856778_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="138" mass="15845" checksum="88801E0A7B76F171" modified="2015-03-04" version="1">MLGTTHEKRLMVDILAIRQSYERREIADILWIKGNRNPADAMTKEKACNALQQMVDTNRLDLELDGWVESIMHFTRETDGKTINHIEPFQTQLRPVILPTPTLQPLQPVAQQASQPLHTTVITRKETSWPSWDGSQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P630</accession>
    <name>A0A0B1P630_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 26s proteasome complex ubiquitin receptor subunit rpn13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001830">
        <property type="protein sequence ID" value="KHJ32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P630"/>
    <dbReference type="STRING" id="52586.A0A0B1P630"/>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="OMA" id="RSPQFMQ"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="42220" checksum="8D0FEDB5DDFE19DA" modified="2015-03-04" version="1">MASNPLITFKAGSCEIDQSTKPYKVVPKLTPGYVYLYMEENLIHFCWRERSKPINHEDNLDLVMLPTDCHFLPYQPSTNEPATKTNGRIFILKFSSSFMRYAFWMQSKPEIPTNPSHFSERDLKIGRVVDKLLQGEEVNIQSEIIAIKSSSGGNNDEDEPMEDVEGHGNFSKHYDRGNGGAGPGATGGDIRKEGASSREGGADGGRAASYRSTDTASIVQNFLNSLRVEQDDQSKLKSLSLHSLLHSSITIPMINTFDPVQIDKLLSQLPLAILLTAQEHDERLENLGKNTDEANEARSSMAIKAMSVECKRLLLRRVLRSPQFNQSLGTLTTAIQKGGLPNIAEALQIKVPNSGLVEGGSVPLAGSTALEAFMIGIKNTIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M2</accession>
    <name>A0A0B1P6M2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M2"/>
    <dbReference type="SMR" id="A0A0B1P6M2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6M2"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="462" mass="51740" checksum="7AA8F2F7B85E5C3D" modified="2015-03-04" version="1">MPREIITVQAGQCGNSIGSEFWQQLCQEHGISQDGNLEEFATEGGDRKDVFFYQSDDTRYIPRAILIDLEPRVINGIQTGPYKNIYNPENFFVGKNGVGAANNWGDGYQTGELVHEDIMEMIDREADGSDSLEGFMILHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTNSGDVVVHPYNSLLSMRRLTQNADSVVVLDNGALSRIAADRLHVQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLISIVASLIPTPRCHFLMTSYTPFTGHNVEQAKTVRKTTVLDVMRRLLQPKNRMVSTIPGKKSCYISILNVIQGDVDPTDVHKSLLRIRERKLATFITWGPASIQVALTKKSPYIPMNHRVSGLMLANHTSIATLFKRIVRQYDGMRKRNAFMEGYKKTAPFSENLNEFDEAREVVSDLIAEYEAAEDADYLNPPEINDQTPGESTDKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P762</accession>
    <name>A0A0B1P762_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002026">
        <property type="protein sequence ID" value="KHJ32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P762"/>
    <dbReference type="STRING" id="52586.A0A0B1P762"/>
    <dbReference type="HOGENOM" id="CLU_108696_0_0_1"/>
    <dbReference type="OMA" id="RFKTPRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="140" mass="15599" checksum="F9F25FB3E1BEED61" modified="2015-03-04" version="1">MLRNALFRISLRVARNTAPRNMSMIHLPTRSTIIPASHTTPSTFQSVRWYSAAAALSEQEVQGRILDLLKNFDKVKADDLNKISPTAHFLNDLGLDSLDTVEVVMAIEEEFSIEIPDKDADSINTVDQAVKYILAQPDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P771</accession>
    <name>A0A0B1P771_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000820">
        <property type="protein sequence ID" value="KHJ34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P771"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34765" checksum="C14F02D807225F1C" modified="2015-03-04" version="1">MEVKLVVSRFIPQELAEIVAMRQCHERVWHARILICTSVISNIDSTLADFKNEISKDEAAALQIYLRPPRENETTKLSWKIVTRNGQKKACVINTSSTKSAQAKNANHVEHLNEPKVTNILSLRQPRKGKSISSIMADKRIFLRLPNEHEWRGLSPAGIREVVVKKLAINISPASIGRIKPVHTGFTLSPCNDDAREKILEGQHGLFMTGAKLEPATSCASVTVPTVPVYIRTLQGKVEVRNTMLADEIERVSLIRPSFLKLYGQNNPAAPHRIWMAFFAKAPRPGFRVFDESGPALQKEKTPRILQTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M9</accession>
    <name>A0A0B1P7M9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative translation repressor antiviral protein ski3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001505">
        <property type="protein sequence ID" value="KHJ33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P7M9"/>
    <dbReference type="HOGENOM" id="CLU_001688_2_0_1"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1417" mass="159054" checksum="45F23C077067E13C" modified="2015-03-04" version="1">MSSPKAILKLIEVSIKTERYEDAVADCRDLIAAHPRNYLALVFLGFALSKLDKYQDAEETYRLAIQVKPNEPQAWQGLIKLYEAQGNDKIEDYQVAALNLAIIYQVADEKYRCQDVIDKFILFAKTNGSRTQYKKALELLLPTSPIFDFLQGRLPPPAQTYQQIAQNIEFDEKERINSLIGERRTRLGARIGQVTIEVKREVMSTSDLEFLYTQIINWSDEEGVRRQYEEKLIQRCLDMMTLLPSGLAKAEKKAKVWELATGIVIIKHPFKLAWDISLEWRDPKNIQDLDVNVLKEYCSFFPTAGLTSVLKGFLNSELSPFPPVPSVESKVQTIYISDSDEEEDEEGGVPLDEPLTAADQLLMISEGMVDAAKSILAHRLSGEFYQNLEEYESVVDLMRGAQRLILEEAERTGLKFENSSEHIAALLGTALVYYQSPKNHPEAKSIFENLLERDPSSTPALIGIGLIYEEEEDYDAAIEFFDRALKKEAGNIRVRAEYAWAKALNGDFAMGKQELYKCLTEMDGKNLQYRDLLAQTQYRYGMCLWNIDTTKANRKDRKGAYAYFLAALKTNLNFAPAYTILGIFYADYCKDKKRARKCFQKAFELSSSEISAAERLARIFAEQGEWELVEVIAQRVVSSGKIRLIPGSKKKGISWPHAALAVAELNKHDYGKSIASFQAALRISPDDYHSWVGLGESYHNCGRNMAATKALLHAQKLERETKQKFGETWLSKYMLANVNRELANYDEAIAGYQGVLCQRKGEYGVSIALIQALVESALDGVEKGLFGYAIERAVEAIEEALLLTINKVDTFNLWKAVGDACSIFSLVQSRLDYFPAANVREILRAGNNDEAYDIFSEIDGVGLEIVTAIGLYSKDESDGLNLTRCIHASILAHKRAIYTSANDKHAKSIAFYNLGWIEYKAHIHLRADAKNRSSRYLKVAIRCFKRSIEIEAGNSEFWNALGVVTSEINPKIAQHSFIRSLYLNERSAQTWSNLGTLYLLQSDYLLANEAFTRAQSSDPDFAHAWVGQGILAIILTGDMKEAHTLYTHALEISVSSSTLTKKQFIQSSFDQLISSKAGMDMTNYVRIFFNLKQLQSMNPRDLSSRHLTTLFLEQVNDIPSALKDLSNISNIVEGDYELTESPISLSRFALIKSDIARCQLSLGFYDEAIENGEIALQLSAEDAGNKISEESRQKCRLSAYLAVGLAHYNLGQIDSALQYFLPALEESNNNSRAVCLLAQVLWAQGDKGSRESARSYLFDCIESHPDHVECILLLGIIALFDQDQESLEAVIANLHELRTTSNISQDGKSQVEDVLQGIAALSEGISNQEVITEIQTDTVLNPSRPYGWNRLSNITGDQFTAEMALKTALRTVFLKGEVDAADLSEMYAGTNKLGDAQNAIMNAPWKTNAWNSLKIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R7</accession>
    <name>A0A0B1P7R7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative snf2 family helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001678">
        <property type="protein sequence ID" value="KHJ33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7R7"/>
    <dbReference type="HOGENOM" id="CLU_071320_1_0_1"/>
    <dbReference type="OMA" id="DHADHNH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="24494" checksum="985C04389965E94A" modified="2015-03-04" version="1">MAPTPCLIYAELLSNIRQISVLAALETPSNTSTKAKLSDDGQQFILLHNGTLQTLQLPGKSLSNFQLQMPALGSKELSWRLPWEVQNKDFSRHDSYMPEVPWPAKSMGTQTELSCRMCNETILERGIIKSWKDLPSEDWAEMMDFWHCHKPDDHKGCNSSNEDANNLKSFESNNNLVERAYGANSKISAQSKIGLVDITTFLLKNEDCSKIQCEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P843</accession>
    <name>A0A0B1P843_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P843"/>
    <dbReference type="STRING" id="52586.A0A0B1P843"/>
    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
    <dbReference type="OMA" id="LQAPYNW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="648" mass="74544" checksum="45B452A66B317E63" modified="2015-03-04" version="1">MAPSIPLPYSLKDFNTTNEYIESLLNFCSTSVLFQTLCGGVHILDFYTQEQSTFRSIIPHEWQEWLLSRDITELMDFLLRQDLLMKEGSKVDGGVAGEIVAEKTVAPPPPESLVNYIRQIRKLSLIRKIPLEQEQEQLQGQQGKQVKKNDTKQSGSLPRHITVGMVPKKIHEVENFAKYVVRLADDIAIHSGKEITHFIDFGSGQNYLGRALASPLYNKQIVAIENKGLNIKSAKNMDILANAAKREIVMRNKKLYRLQQLTSKKMKNLTFDEKMEKIEKLQNQNTSHIPVDLRPSRELDAIYTKQAGKGHIQYLHHEIVDGDLTNIIDQIEHPKIKLSSATPIDDQTLQSPEEQILEIDKFNSKPEDLNLMVVSIHSCGNLSHHGINSLLQNKKVRAIAIIGCCYNLLSERFTHSSLKHPLLRPNKCPINAFRLIDTNKSEDPHGFPMSQRVSTYNEKGIRLNITSRMMAVQAPYNWTEKESTTFFTRHFYRALFQRILLDKNIIQLTNNKIVGVLESTDAIIIGTLSKNCHQNFKTYVREAISKLSKNSSQNQKNQKNQIFWENFNLSITDLEIEKYLQKYQPLKKELSITWSLMAFSAILIESLIIVDRWLYLREYSNIVDQCWVEPVFDYHLSPRNMVVVGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E3</accession>
    <name>A0A0B1P8E3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001572">
        <property type="protein sequence ID" value="KHJ33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8E3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8E3"/>
    <dbReference type="HOGENOM" id="CLU_027370_0_0_1"/>
    <dbReference type="OMA" id="ENKTHEC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="57232" checksum="9338D532443909A7" modified="2015-03-04" version="1">MPIDNFELEQIIQGLMENLNILVDQTPKLIDREKILSKKLEIARGLYKQLASKYAIGDLEVTNALEQLNSPVPISMGNNCPYASNISSEQNLTSQSQLTTVIDDVRLVSHQLTKIFNQLSGSTLSPKIIPTTSESLLNFNNRAPQSTLQETDLTVSVRKSTLECPFPMQQKKLELPSSKTSPQLRINVGSGLEFKNNDLSTDNKDMVTRKALCCEIRDFPNSATTSSKCPIRYLGQRSPEEVARYFEVHKHEIPRSHEICLKRQQKNEDHIRKLDAKYGDLVNIIEVLGQKHQPLLPDTHKKLSTPLGSNERLESWVRNVSCDESNQENKQESSDKNDQVPMSDRPLKEVRVGESPSRPWGISVPFHSPQNGSKQDFSRSTLASTVNLAKSIEKNPSQENKTHECFCEKNLSQVQESQRLSVINNQSNYIGDEPPIVSNPLHHTNKPQKSLSNPHVSPVNHTRPNFVKTHDHSLSASNVQKTHMLFTGPVFIDYPTEEAIKIIQKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H9</accession>
    <name>A0A0B1P8H9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000577">
        <property type="protein sequence ID" value="KHJ35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8H9"/>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="OMA" id="CAGMSGM"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="27026" checksum="C94137EA6E53281A" modified="2015-03-04" version="1">MSIKRILVINANSSPKLTEVLDNLIKDHISRFPSVATIESYTAPSGPPSIDSDHDALVSARAIMADLQFRLEDYDAYLVASYCVHPLVSMLKARVSHRIHVIGIFEASILTALSLLPTDSDSKFGIIASDAYWVDSLTKGINKLCCTDISGHKKFKGVGVIGLTADEIYSMESEEISSRVKKAAMKLIEDHDVRVICLGCSSMARFSGAIDDALREEFGDQARPVYILESFQAGICLVENLLRAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K3</accession>
    <name>A0A0B1P8K3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001293">
        <property type="protein sequence ID" value="KHJ33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8K3"/>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="OMA" id="PFFHMLE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="14">
        <location>
            <begin position="70"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="33991" checksum="B7F9A8D39A97C387" modified="2015-03-04" version="1">MNSSNERMAKSSGTSENSSQLIQTIKQNLAPSTARDTPSRWSVKDIASQLPSGAPIEGSKSPIPFFHLLERLKTTPREGWRRFGVKNAESISDHMYRMALMTMFAPQSLVGIIDIQRCTKMALIHDMAEALVGDITPVEGVSKSEKNWRESTTMDFLTKNILGNVDGGNVANDIRAIWQEYEDGETLESKFVHDIDKVELILQMVEYERAFDCKIDLGELTWVTCKILFPEIREWSHAILKEREELWAKQEHITYTSIGNPAVIEAEMLSKALKHRGESLAEKEPKANGHIEGLNTSPMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8M7</accession>
    <name>A0A0B1P8M7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001288">
        <property type="protein sequence ID" value="KHJ33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8M7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8M7"/>
    <dbReference type="HOGENOM" id="CLU_002055_4_0_1"/>
    <dbReference type="OMA" id="FFRIWIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="257"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="750" mass="84148" checksum="7C6750175712E0EB" modified="2015-03-04" version="1">MLLQMAVKAVNDSAGPDGLVPTLLVYGAFPKMSELDPPSPTIAQRATAIRKAMEEVNRLRANRQIKDALSTRNGPATASLHDLPLNSDVLVWREGNANKNGKWTGPFTLLSIQNETCSVQLPSGPTNFRSTVVKPYRKDDVPETFPPIDFPSQTTSHQSIPSSPTQNIPNSTPQRTGTPPPTMEPHRILRSSLKSRIRTNLSQIPIDVSNGNSDLTFIYDMQEPTLHASQLPHILTESFTESRRKEINGLLEKGVFKVVSISDIPLNSRIFNTRFVDKIKHPGTNKAFKKSRLVVQGYNDEGKFMILTQAPTIQRSSQRILLALASMLQGNGVNLYLRDISQAYVQSSTNLNRIIFVQPPLEVELPPNTVWQVLKPLYGLAEARNHWFSTYHRHHIEKLEMSPSTYDPCLLYSIKDCMGIVGMQTDDTLFLADKIFADKEQKELKIAKFLAKDREQLTINTPLKFNGGIATLLNNTIMLQQTQQAQNLHLIGTRDIDMPCAKGKTKKRATPKDQYIAQRARGAYIASICQPEASFDLSFAAQVVNPKEDDAKALNKRIQWQIENPKRGLKFVKLELNSLRIITFTDASFANNADMTSQIGYVIVLADSKNNANIIHWSSIKCKRVTRSVLASELYAMALGFDISAAIKATLSKILQKSIPLIICTDSKSLFDCLVKLGTTREKRLMIDIMSLRDSYERREITEIIWIEGNSNPADAMTKSKACRALKELIDTNKVNLKVMEWVDRKCFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8M9</accession>
    <name>A0A0B1P8M9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative giy-yig catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001537">
        <property type="protein sequence ID" value="KHJ33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8M9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8M9"/>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="41043" checksum="A2E18280CDE0ACE3" modified="2015-03-04" version="1">MDRPIPSFYCCYLLRSIPRPSSVYIGSTPNPTRRLEQHNGLIKGGAVRTSRTRLRPWEMTCVVSGFSSHIAALQFEWAWQNPHITLHIPPESRIQPPTSRKRSGRLKRPIHSVLSLLSNLHLLLRVPSFCRWPLELHFFSKDVFDKWSKNCRTTLEQIPSHISILQDFSTTNMSSSKGGCCDSVQKPFYQSARELVIDYTNQRPHVEKAKNIFDFEQEGTCPICKSDLEHNQGIYTVCPNPACNSVTHMTCLSKYFLDEDDDSLLPVKGECPACHSVTRWIDVVKELSLRLRSSKDIENLLKVEKNSKTKKAADPLSQTDVGSEENENEETDTSLYYEYDINDENDGFETASITYSTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P923</accession>
    <name>A0A0B1P923_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative air1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001592">
        <property type="protein sequence ID" value="KHJ33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P923"/>
    <dbReference type="STRING" id="52586.A0A0B1P923"/>
    <dbReference type="HOGENOM" id="CLU_046750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="38934" checksum="F9D553D58DD86080" modified="2015-03-04" version="1">MAGVEAGATQAIGKNAIQTSENGKFHSSQVAIEKIGDVLKKMKGCLNKVGLKGVIMTVEEVDEAIEALNNNRFIWLHATQNNSLEHRILALEEAVKKNLVENCGRMGSKGVVGKSYASVVAPPAAKAAVRIRVPGAAELQPVELLSIAKQKIKGAYAIRQMRSHDTEVFVQSSNHRDAALSMEQPKDFKILRKYFPVEIAGVSLSTKIASGKNADNTALMSILTNASKVRIPGLQIKRIRWLQDGKEHEKARKKGHTRGSRAVCKTFKVYKEGVERARLENQIKTAEIRSEKIPATEAKYVPVNTSDEEGFTLVTIKSSETKRGPGRPRKDALVPMTSQIIATSPNAKVGIPLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C2</accession>
    <name>A0A0B1P9C2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000673">
        <property type="protein sequence ID" value="KHJ34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9C2"/>
    <dbReference type="HOGENOM" id="CLU_053559_0_0_1"/>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="339" mass="39833" checksum="A6D88CECF7958E4E" modified="2015-03-04" version="1">MADKSGSTKYHRDIKIQLKTQTDLARDSCSKRPKYHHHQAQQHSRKRKRSLCEILPTLPFNSKPLAKDHFNEYKPIFGLYLDIQKNKIFEELDVKEVKGRWKSFMHKWNRGELSEGWYDPSTKQKAYEKAIIKYSQTVEEVPEIVPKRQNGTDSCSDIESNDGNQSDQSFGPMLPGQEMRSKSRKLGPTIPSIQDIQLIRENAADARIARYNEEKMAQKADLNEQKAILDELIPQSMAGTRERKLEKKRDLNEKRKSFREKSPGTVDIPDSDLLGDRNDFELYQKAKREMERKKNERELRKEAFLRVRVAEREERLRKYREKEEATIGMFKALAKERFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9S1</accession>
    <name>A0A0B1P9S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dynein heavy chain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9S1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9S1"/>
    <dbReference type="HOGENOM" id="CLU_333506_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="857" mass="98850" checksum="B4E8529366263D99" modified="2015-03-04" version="1">MDCSWVKTLAKRRPTQSPPFYENKKGTFDSEKICLGLGIDDIHYAKLLEFINYLIGPNSLKSRALTRDIRRRLRKTLDPILHNLPPAWAAKCIDQLIVKASSNASGARRNERVRAMDPKKDLPQNPDSLYSIRAASSTRIEPPQDLPTSIRQAPTQPGWPSAGYQLDSHGPRDPTQFPRRRLVPSTNFDTNIRRNSEGITEEIVRPPSVHVKREFEPDDNIISRPTKGYIVSRDPPEVNRQISRATMDRYIPEFETDRFIIRNSYPPEVLRAPEDRSFEERARERRALEERARDERIRDERIREERIREERIREERIREERIREERIRDERIREERVLEERARERRALEERARDRRAPEEWPRERRAPDLWAPERRAPDLWAPDRRVPERRAHDRWAPEGRALDRWAPEVRAPERRAPEARAPDRRAPEPRAQERRAPEGKLSEVRALEKRVSELKALEVKTLEGHALDANVPEIKTPEIKVPEVKVPEIKAPDVKIPEIKASDVKVPDEKDPDIKASDVKVLDIKVSEVKAPELKVSEVKALDEKTSEEKMLVKWVPEINYHLVPTSKAAILGPEMLAQKDQTQQVLGEKATEQQVAKDQAPAEQIFERESEENTTFEKQASEELNSSTQAPEKVIAEGTILDEKDSQKPLPRDVDMEDKVSKTTIDDFPDNSTSVSNHDTKQEPVAETTFTEKPIKKVPINQIAFMARRDFGDWVLLGTGNDLMGVTGAPDWDIFLSRLKVGLKFSPDTDGLFCPWLGYTNGEELVGIFDSFGWKAGIWNMYQRGLSELRFEVKKRVSSSNSNPQQLQKNQQNQEQQLQDVLQESFVETEVEEVDQEVTPARSSSLSSLDSYNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U9</accession>
    <name>A0A0B1P9U9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rnp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000568">
        <property type="protein sequence ID" value="KHJ35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9U9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9U9"/>
    <dbReference type="HOGENOM" id="CLU_012062_23_3_1"/>
    <dbReference type="OMA" id="YRGRATY"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="191" mass="21172" checksum="A9D290F8F70ED971" modified="2015-03-04" version="1">MAGSETYVETNNNAIAQDDGNEEDEISAMKRRVAEMEEEAAKLREMQASLDQQSNDMREDPEDIDSRSIFVGNVDYSSIPEELQAHFQSCGSINRVTILLDKFTGHPKGYAYVEFSEPSFVAQALVLNESVFKGRNLKVVPKRTNVPGMTRGRGRGGFRGRGYSGRGGYIPRGGGYRGGYRGVRGRGFNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W9</accession>
    <name>A0A0B1P9W9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000556">
        <property type="protein sequence ID" value="KHJ35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W9"/>
    <dbReference type="HOGENOM" id="CLU_676516_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="46318" checksum="8F4FBC1AA4F57CDE" modified="2015-03-04" version="1">MALSNVSTPMGTQDLAQLIIRSCNIQSRLVNPTNSGKYVKKWMAKYFLYVKKLMIDVPNRKLVKKPQSSKRSLREKNSYCCEIDTPDSGKTYLKPVLSNKADHPRKKIKIRPIIISEIEVQLSPSEINSLELSNKPCIALGDLTCTNYETLSTIKTSRSDVSFSRCISPTIERYREGIYRASQALSKTDDTARVRTRSKHSYKKYHRNDATSHLQNSWKQSGYISIQAQKPPRHQESCQTAQHHPILPTKRIGRKNYYVFTFPKPPTGPGLASLFHQLTPKKGYYLQVIVKYNDQMKDPLWATLLQSALSESCVKELCIAIGRMYVKFNLGATNHIKTQQNLRDVSKAISILNKNIKAGGQSLRNMVNFLLKKLEKDSIEGKWGKREQSRRGKRASSNPVGYGIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC3</accession>
    <name>A0A0B1PAC3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bzip transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001158">
        <property type="protein sequence ID" value="KHJ33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAC3"/>
    <dbReference type="HOGENOM" id="CLU_728010_0_0_1"/>
    <dbReference type="OMA" id="HESTTQH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="43206" checksum="E34A77AA5D8CF266" modified="2015-03-04" version="1">MGTLPSANSSIFAMNQLQECAFTSQEDGDDDFLDLQTIPNCEGAQNSSEIDVDFDSSTSEPAYFHPTLTNIALTDLNTVSGQQLYLPPTQRDDINCLWPGINQPQTFTEIQPKHESTTQHSRLRSTSQGLLNRYSSPVMRTISPIKVVSPPRDPIVEEKITQLLKSIRQTNQELEISGEHAISNFSTRSLSKKEEEMDEDEKLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYINQLEDEIALRINENVDLRAQIQALMEENVRLSDFTRMLVSSPSFTGFFDALAINPSSNLNVRAYQQQSEKTNQAQLQLEKEANHHVIQQQKQHQYLGMAVLPESPVDLTMLDLNCEENDACQPRIYFTQNIPETILDYATISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB30</accession>
    <name>A0A0B1PB30_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB30"/>
    <dbReference type="STRING" id="52586.A0A0B1PB30"/>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="46"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="204" mass="22320" checksum="3892FC7ACD260B93" modified="2015-03-04" version="1">MTSNHLLEEISALSPKNITIAPPESSGLFSSELISPEVAASLPSTYCIRALRKSDYGLGFLDCLRVLTTVGDISEADWNERYEWMNTQGKGGYYLLVIEDRGRIVGTGALIVERKFIHQLGIVGHIEDIAVAKDQQGKKLGLKIIQALNFIAEKVGCYKSILDCSEANEGFYVKCGYKRAGLEMARYYGGSNVSKITSNPSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBD6</accession>
    <name>A0A0B1PBD6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lysine decarboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBD6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBD6"/>
    <dbReference type="HOGENOM" id="CLU_058336_1_0_1"/>
    <dbReference type="OMA" id="MDELWEA"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="227" mass="24813" checksum="539B6301EAA9440B" modified="2015-03-04" version="1">MDEQRTSSIAPKNPKQVICVFCGSSQGKNSEFMESARELAHAFHQNNVSLIYGGGTCGLMGELAKVLTSLSGPDAVHGIIPAPFVRHENSDFETDISLLLPDKKIYGKTTVVKNMHERKQLMISEVLSGAPGSGFIALPGGYGTMEELMEMTTWNGLGIHDKGVVVFNIQGYWSNLLSWVENAVESGFISANTGAVIKEAKTADQCIQLLKTYKCEEGRLRLDWNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBP7</accession>
    <name>A0A0B1PBP7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fyve phd zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000133">
        <property type="protein sequence ID" value="KHJ36127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBP7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBP7"/>
    <dbReference type="HOGENOM" id="CLU_020879_0_1_1"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="609" mass="68884" checksum="C2781B168EFB0474" modified="2015-03-04" version="1">MDTTRRSLRAFRASQPLSISNQVTNPSSRAERTTRSTIKLDSSEKTTISGPYSTLKPEESVVPTEDSIIMQTRRKRGRTEEQRDKPLRIQASQVHNLSRSDQVGDDDEVVRCICGLDDYSGLPKSEGEVKSESQEQIVEPLNSVTDVAEDLAGFFLQCDICKVWQHGGCVGIESESSSPDEYFCERCRKDLHKIFTATNGQRYSHYLPLYQSLSRLTPRPRPYSKDEIQSPKTAGTAKFQSLQANAKRRSTMNSRDAAYDEEEQIRRAIEASKDIKAVENVDGCLRRGKRGRSNSQEKIQGLKRQRTDSASSSSSSSQEFNQISPQPESDDGGNERMINSKKPRSTCSKTLREKDLKDDKEKSRSDAVAKRNGRTERRRTEDQETQKELSIGTKNTMCNSTDSSKVSTTIESLESPTLSNGRVSDNSSNNQFPIPLKKSYRNSNSRKGKLAKNNFTRESDQQIHDDQHSHRSQSREAPKIDDVPLTFSNKGSHGEPRVTKFKGNPSKVSMTDMKRRISAILDFISRTQLEMASESIYHITENPIQKSAQIQTDAVKILQDECNQEGCLDDISHGSENRHSSKEFKDLSCRDMMDVLTKQLIKWQKDFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY0</accession>
    <name>A0A0B1PBY0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY0"/>
    <dbReference type="HOGENOM" id="CLU_009193_1_1_1"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="9">
        <location>
            <begin position="466"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="970" mass="110926" checksum="E7672402F4EFC39E" modified="2015-03-04" version="1">MLLTYMFGLRHFPFTFVIQSLPKIRRVPVTVSEIYLCAASIHFLLPHDRPKESKLSIKLVHKLLKMSDISEDDVPLARKRMRKSARNTKVSETNNATAKKIDLNVTENAKPSGATNREGPALKEKVKGNAKNTSNSSMKRKSRGSMSNNINYNEDIDEDSEEVPLAKRPRKSLKTNDSHDHSPQSSNRKGKIIPISDVNNPDSSGDEEHLSQKISIKSASIDKSAMKGTQKADSKDTKPKTKKATKIEGNSRKINENSNSASKKRASINSKSKIVKEEVNSDAKFLKNEGKNSEEAEEVYKWWLEEKDDDSIKWTTLQHNGVVFPPEYEPLPKNVKLLYDGISVTLSIEAEEIAGFFGAMLNSTLNVENPVFQNNFFEDFTDEIKKTGGAKGPNGEKIDIKEFSKLDFKQIFAYYDGKSQERKAKPIAEKKADKAAKEALEAPYTHCIWDGRKEQVGNFRIEPPGLFRGRGAHPKTGKVKRRVTPEQITINIGKEATVPTPPSGHKWKSIQHDNKATWLAMWQENINGAYKYVMLAAKSSIKGQSDYKKFEKARELKKHIDRIRKDYNKDLHSELMADRQRATAVYLIDKFALRAGNEKDTENEAETVGCCSLKYEHITLKPPNIVIFDFLGKDSIRYYDEVTVDPQVFKNLKLFKRPPKSDGDDIFDRLNTTQLNKHLTNYMPGLSAKVFRTYNASYTMSTLLKELKNTNISVQEKVKLYNDCNRKVAILCNHKRTVGASHEAQMEKMTDRIKALQYQQWRLKQMILAIDPKQKKRMGASWFEMHEDLDVAWILEHQKFLVEDMRIKIEKKFHKENEKLLADGQKEMKAKELEERFETAKKLESKFKKENQTKKIEPEGKGLTVEKFVANISKLDDRIANMRLQAEDREGNKEVALGTSKINYIDPRLTAVFAKKFEVPIEKFFSKTLREKFVWAIDSIEDDDDWDWPVKSKSSPSRGAGVNAQYALHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC74</accession>
    <name>A0A0B1PC74_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000818">
        <property type="protein sequence ID" value="KHJ34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC74"/>
    <dbReference type="HOGENOM" id="CLU_1961203_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="128" mass="14481" checksum="47BE9EFC639C2D5F" modified="2015-03-04" version="1">MDKETPIILAPGVSSTDWESDLQATLVKKGRLAHVFHDLEYIDPAIRPFAPIKREGQTDDQCQQLLAKYKEAAARWKQGKIEAKNVLIRRLSEGVRSQDYRRMSAKQIFDNIASSHEEGAAIPYETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCU9</accession>
    <name>A0A0B1PCU9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01000148">
        <property type="protein sequence ID" value="KHJ36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCU9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCU9"/>
    <dbReference type="HOGENOM" id="CLU_023643_0_0_1"/>
    <dbReference type="OMA" id="ATHSCID"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="39992" checksum="E2B68D11A7C05472" modified="2015-03-04" version="1">MSLNDSPDISELEKLHDIPEPKQQIPQSLRDLAEYIKQGHSKQIIVMTGAGISTSAGVPDFRSPGTGLYANLARLNLPDPEAVFDISYFRSNPIPFYALAKDLQLEKCYPTMSHAFIALLNEKKLLSMLFTQNIDGLERKAGLPEEKVVEAHGSFASNSCIDCKTQFSCELMKIAIETGDVPHCLVPQCNGLVKPDIVFFGEALPQSFLLSQSLIKQADLIIVMGTSLTVYPFASLPSQAEMGVPRLLVNKEIAGDFGSRPEDTIVLGDCDGVILKFAEALGWRVELERLWFEVSQKFKIKEAEVLQKKRNEMTSEEKFNSDILRLTEDVDRSLKVSKDHINKITEELRTSKEKELSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY4</accession>
    <name>A0A0B1PCY4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000144">
        <property type="protein sequence ID" value="KHJ36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY4"/>
    <dbReference type="HOGENOM" id="CLU_063301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="31534" checksum="873F381856E34292" modified="2015-03-04" version="1">MNGIMGQLINITSALSDLKTNKDKDKGKETVEEVVTAPSQSLFAPSKPSTFFKPISDKFNFAEASNPSSSFKISKTERLDFSSLRETTTLPEKRKSQFAKQRSSTGNTTEYRGIQTSKEGAINLYQIPPSNATHLTQREEKVKKYFPDFFPRSEVENPDGLLREVTKRNRVVISSELKLKHANLQTLEKLHHMQVAMIQSMLPYTAWPVRVALKMDKDFLAARRAINNHSLDWAGAVDCILTVLFKHNVLGALLTNLARLTVRTGETSLQFARRLRKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD63</accession>
    <name>A0A0B1PD63_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4881</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD63"/>
    <dbReference type="STRING" id="52586.A0A0B1PD63"/>
    <dbReference type="HOGENOM" id="CLU_004222_0_0_1"/>
    <dbReference type="OMA" id="THVGPWQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="120"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="585"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1260" mass="143506" checksum="CF73E4AC067C0F08" modified="2015-03-04" version="1">MSYINCRPLNLHPLGEATQPVNTSSLNCHNIRFSHNQDSYQSLQDGTYESERPRKSSKGSQSPKILSTHQPSTSVGPNLLCPKFPPSIHNYGVRVENRISAVSETSSGTRGKLKSLIGPWKLGKTLGRGSSARVRLARHQITGQVAAVKIVPKIGAQISQSGSLANFEKAESRLHNHDDGLKHMPVGIEREVAIMKLIQHPNILKLYDIWENRKEIYLCLEYVDNGELFEQIAQNGRLKEEEAMGYFRQILSAVEYCHSFNICHRDLKPENILLTSSGQIKIADFGMAALHQAPGQQLSTSCGSPHYAAPELIRGSKYHGNMVDIWSMGVILFAALAGRLPFDAEGVSKEWLAPLLAKIKKGQYNMPANFSPEVKSLIRSMLQINPKDRITLSQIWKHPLLKKYDYLDNLGQEPYSLLPSAHVCRHLRLQRSQVSPEIFRHLWSMWHTFSEKQLMEALLNNEPNDQKLFYALLVKFRDTQLENYVPDIRYSISDYHHVNPVKLTRTLSTCHFSQPGERRHNRTISKFTVIKNNAKNEQSYTSSKDYPQRLNPDDSYKKNVHDIGLQRKKDPEITVSVRQVPRIDSQATAREKRNHHLAPATLTSRSSLISSTRSRNNAGKIRISFEKKRGVSFNHLHKSSKTNQGSISTDLQPLHKYGYQSSLSKVANNDDNKLAHVNVTKLDGASIESLSNKHCLTSHEKISATEKFSHIFENFKEDIRVHSNCLAKDCDEAFNFLQDPLLQDSKTQIKPKASSTIIKKKLSVSSLNSRPLSQPSVTQIISMRSELLHAREKAEIRRKAGGNESSSYLNQLVAHIDKLLQHLPPINSYNESPVVSVSMDLKNFTAKGFYLPISKNDPEALHPHFQRSQNHEINLNCNFNKPLGDDKQTEYLSAHPCKDDSWTAWSSTLSHRSDSDELQLSSPDRPMDIPLPLAIQKKMLISQQISSPVIEQVCNPKKSFLPNESQTERTTTAKIDPVSQRYKQAKKDVYLNDHLNKYSPFSAKRNLNWFKKDLLREAHIESNEKQPQVLRNFDNTGEHLCEGRFCIPSAGSKKPGFGLGKFFKKQHYKLDMMFCNNHGYDDLYDNTTVGDFITDVKCCSNVRKSIDYKNSRYRQVVPQRNWWARLFKVKPVIRFICFSIPKKKALLEILGLLREWRRFGIEGIQVDKSRSIIFGQVGVENYLQIKNVGFATEFMTVIEHGKRSALSIARWTQEHGAASSFHKVVDTIEKVLKERNMLVAIEQKRNMMVKTVKYLPAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDL0</accession>
    <name>A0A0B1PDL0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative gdsl lipase acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000728">
        <property type="protein sequence ID" value="KHJ34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDL0"/>
    <dbReference type="STRING" id="52586.A0A0B1PDL0"/>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="OMA" id="ANSHCEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="29023" checksum="4B3D343ADFD1DDF5" modified="2015-03-04" version="1">MSGREQFILFGDSLIERANLECDGFQFVNQLENALDGRYEMIAHGYPGANTYHALDFLKNVIPSPEKAKVRFLAIWFGTNDADKSRPVSIENFEKNLISIINSPQLCAHLPDINIILITPPPVEESLLVEHKKKKYGLEGPPHLTAASAAQYAKKIQELVQELKSTNKEQTIEKASCQSKRENKFKRQLEVLDVWGEFISMTEWREGTLPGSSILGVDQILSELLIDGVHLTTAGYKIVLSAFYKLLRTKWAQFICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE04</accession>
    <name>A0A0B1PE04_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative kinesin-related motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000498">
        <property type="protein sequence ID" value="KHJ35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PE04"/>
    <dbReference type="HOGENOM" id="CLU_001485_20_3_1"/>
    <dbReference type="OMA" id="IDRGAKC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="9"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1397" mass="157531" checksum="AA258024F2C5E20E" modified="2015-03-04" version="1">MPSAASGGNIKVVVRVRPFNAREIDRGAKCIIQMKDAQTILSPPPGFEERLKSKSSGRDIGQKVFAFDKSYWSFNRTDAHYAGQSDLHNDLGKPLLDNAFKGYNNCIFAYGQTGSGKSYSMMGYGKEAGVIPQICQDMFVRIENIQKDPNFRFTVEVSYLEIYNERVRDLLNPSTKSNLKVREHPSTGPYVEDLAKLVVGSFNEIEHLMDEGNKARTVAATNMNETSSRSHAVFTLTVTQKRHDIESKMTMEKVAKISLVDLAGSERATSTGATGARLKEGAEINRSLSTLGRVIAALAELSDGKKKKGGKGVGQVPYRDSVLTWLLKDSLGGNSMTAMIAAISPADINFDETLSTLRYADSAKRIKNHAVVNEDANARMIRELKEELEALRGKLSGGTGGPSEEIYPENVPFDKQIVSITQSDGTIKKVSKAEIAEQLSQSEKLYQDLNQTWEEKLAKTEEIHKEREAALEELGISIEKGFVGLHTPKKMPHLVNLSDDPLLAECLVYNLKPGTTTVGNVETNTGQSLEIRLNGSRILHEHCTFENIDNVVTLVPKQSAAVMVNGNRIIEPKRLRSGYRVILGDFHIFRFNHPMEARAERVEKSSLRHSIIAQHIGDTDGFSPSSASKLEHERKLSRAFSEVEWDGTRPNSPLMYRTRDSDWSLARREAAGAILGSDKQIAGLTDEELNLLFEDVQKARAERAFQCVDDDTDSIRSYLIREKYLSNGTLDDYSFDTALTTPSSPKQGEAEDSVRDVREIQNKLGGDDEGHQEISMLSNAINRDVEENFKKETLIEEELRDIKVETLSQLDEQRMELQECIQEIDPQKIELAEILPALSKEEQNIARRTVGLWRSRKYIKMIESILIAATNLKEAQVISLELDQGFFFQFTIIQTGHEICSSYDMVLNIISDRDDLHLEEAAKPCIGVRVIDFRNSVIHLWSLEKLQRRVQLMRQMQKFMDKPEYLRKNKPQNPFTEKFMPQFTHVGDADVPLSAVFESRVQDFSVDVVSPYTSHVIGILRLSLEPSLARAPSTTLNFNVIVHDFIGFAEREGTDVHVQIFLPGVSEETSVSTSQMIRDFDEGPIRFESVHNQSIPVSGSAQSYLRIAIFARVTSMHFEKLLSWDDMQDNNAEEKRQRKITRVSESAFLNEERYKIFAKIKILELAENGEYLPVKVVHKNNHDKGLFQLHQGLQRRVMVNLVHSSDDALSWQNMSSLRVSELHIEDNDGNILSKGNQSMMIPLRLISKPILRQNCNGTSSVTLIGQWESSNYSSLILDRITADKLKIKTIFSWDLTSPKLSTPLTFSMDTFSVILPRYHFDYSSILSSMFQKFKASFSVSGIFSVSIFPSPMKTARDLWLISTLDNYVKGEELLAQWRPRGVSLVWDYIANKKRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE90</accession>
    <name>A0A0B1PE90_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phd-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000608">
        <property type="protein sequence ID" value="KHJ34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE90"/>
    <dbReference type="STRING" id="52586.A0A0B1PE90"/>
    <dbReference type="HOGENOM" id="CLU_009510_1_0_1"/>
    <dbReference type="OMA" id="IKCICSF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="282"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="957" mass="107918" checksum="01B39FDFB5C0104F" modified="2015-03-04" version="1">MTERHPSVTTPSAIHNNALYFPPTNDAPFVFESADEEPYTIKCICDYSDDDGNTIYCEKCDTWQHIECFYPGRVDDASREDFDHSCADCKPRPLDRRHATERQKIQRQNKSSCYVGDKKIKRPPSKGQKKKSKGSEVQKNGIYDQDVIRNGIHEQQPFMKKSKGNRSSLSINSQSKKSPPYNTRTETNAQPPSPVQTPPHLPINFQVHGYSDNFLTLYNQGPIHLTCTNSFASLSVSNSMTDWLRDQSRLFQDAGVRNKEDVFLNLKVSVDTLKWPELRVERKEEAFQNMILHRQYLITPRQLPQPGRIVELNGLVCFQKDYCSDPENRWTETAHPRPFVFFHPLLPLCIDTRLEGSIGRYVRRSCRSNTSLETFIANGTEYHFWLTSEHPLAANEQITLSWDFRFPPQYRARFLHLLNLGEEDSLHFDISDITQEEYDQLTQTIRLVLSEHGGCACDLGHDCAFARFHRNYIWGTNLQNSEVKSKKVRRTKLPQASPTSLETTTSIRALNETKQDNNDEGENHSTNGSVRSKPLSRDLTPATTNSDNNYILMEPSDREKRKLAALEDSFRKMEQGQPARKKKKATDNNLTHSQSTHTVSKSRQRSIVTSGLPTIKAFNSSNSNSRIRQLDTNSPKNTGSTSLSTAKSDTVSPPISATPFDQSPTSQLPKSSSQKPPYKDSATQTEEVKYAWWRESGKKKGKLIISLARRLLLNRYRKDLRDLPGTHDLPTHSENPSIITLSTPKRGLEVQVRNLKLSSPNKSISPSSETSTIVDLNIYNSISQTSNYPTVSDSPLSWSKSANNVNSKSKTSHLDVPPDIGATFLTPMSSSNESEKLDISSISPLNVVIPSPSPSNSANANNFQQTIINNITQNPSPIRTTKKLSLSDYKAARMKKTDLSTQVPKTPIEKKRSEINHAASKSSSQMTVHELKPSIKLEESTNKDLPIKDLCSISATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEA2</accession>
    <name>A0A0B1PEA2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative escrt-i component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEA2"/>
    <dbReference type="STRING" id="52586.A0A0B1PEA2"/>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="468"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="59906" checksum="BC2D95830B15D4F0" modified="2015-03-04" version="1">MATTINQQVLDWLYGALINDYTHLISTYNNVAQLLSKYSSLSPRTDIFTYDNGKSALLLKISGTIPVSFRGTQYRFPIAIWIPHLYPVEAPLVYVVATEGMVIRPGQHVDLQGKIYHPYLVGWADNSDIFNLIDFVEILRDVFAKEPPVILRPKSGTSQGAISISSETRRPTSQVSWNEIQASPPLPPPPPPKPQKDNQQSLRPGTQKWESGPPLPPIPPSLRRPHTESNHYSYQNQLSQRPNNLIRQEKNGIIYDSASSVPEQNHYDSQRSAIPYYSSSILSDSKNNIYQEPSLSYSQITSPLRHGEQIQYSRQQTFQNQTLQPQLASNASESPSPRLKPTPPDLLSAPLVIDTLLPSNTDHHAPPIPSNPEKELLLQKIGHELYSQRQKTREQIDSTITGLQAQRDAMLASLGKMEAELHALDLLHNLITSNTDILHTSLKQADNVIISSQHRKPPGVDELLVAPHVVGNQLYELVSEERSLGDALFVLARSVEKGRISPAVFVKMTRSLSREWYLKKALVRKIGLGMGLITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEJ9</accession>
    <name>A0A0B1PEJ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000546">
        <property type="protein sequence ID" value="KHJ35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEJ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PEJ9"/>
    <dbReference type="HOGENOM" id="CLU_044609_0_0_1"/>
    <dbReference type="OMA" id="HQTNIDK"/>
    <dbReference type="OrthoDB" id="3918393at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="378" mass="42793" checksum="BC21073975CADEFF" modified="2015-03-04" version="1">MNVLKESNNSPVSNSTTQNLISGIKRSVSSHSSPLGAVISENLDHSENRGNSMPHSTRPDSLFNSSNSKLPIYVSNATIFNGMSRNAQKHVSDFGPMLSYSGTNNNDAHLTSPSMDSYSASSVTSWNSAIGRAGLGGKSGRVIERLMGDNDMLKRDLKIERLRAEEHKQAVKLAEGRMEALSAEYEGKLHDAAINKTLLKRKERQLADLRQQIEIEKNKAIAAVESERKWKEEIEKVESKAKRDIEDALNYAAMMEARNNTMTNHWKDQGLEVNRAVAKLSKEIEDIVLERKQDDERLNTLQGLCDQQATQFSEIVRERDEISKVYEEYKSTQEEALRDIKRLSRKQREESERVIAETTKTLNELKWALGLKMNERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEN9</accession>
    <name>A0A0B1PEN9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1441</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000527">
        <property type="protein sequence ID" value="KHJ35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PEN9"/>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="499"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="689"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="888"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1795"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2159" mass="244301" checksum="72843006A88D29E7" modified="2015-03-04" version="1">MVKGSSQTIVTGVGHSPHGSHHSPFTAASPSTNSPTGSNTLTNLVVAQVFFLLSNIKEDKDRTKWEQQAEQLKKLIDANGMEVFQKYFSRLVVGNAYQIFPGVNRQITTPGNYSILVMEIRKISQDVEQARKIAESIEMANEDIFRDFDLSTFMDHFKLDALEKTILALAFKSGSKSDLKAKADAIISNNYSQFLQFLARKNNDESFGPDFVATIVDRLIQTNPPCLDQKARNELVLAVQFRYDTRDFEHTPPTAVLASLYLLRILSDQKSLAFYMCGTGAAFTKDNDTCSEYLQNCSHLLTEDNVSTALIYSIISTTHKFSPEIFVKSLRREVPATFDWSQVISHFDQQDLRITQQQFLNLYKAVQPLALEEIIDIQRLWGGKWCHTETQLSFITAYASLNPSELDATTIPRLQKTFTIKEYSDSPPLVQKRAAYAVTDPLISVAALEALFHVALHETAASETPEAKRLFARVVLPKLDIFMVSAFGVPKPWPALANDTLFGLFDRYLTQADPHRDFVLESLWRKDCGWVAQRLVDAHAKTPLRLPVILDHAFRHKWLNDLTSMHNGFGLDLAAIAHARGLLNLDEWRRNVTGIRIPEFAQSLKKFLDIKASHELSFQRTGELSSVMLPVKTVAALLNLLEEIIPKSPAHDWIAVQRRCITAYPRLINYNEGFNDIIDANGAEANFLPAAANEKMEEHYKRMYSDDLQVRNVVDALEGYKRSRDPADQDVFACMIHGLFDEFALYGTYPLEALATTAVLFGGIISRRLIENLPLEIGLGMILEAVRDHAPGESMYKFGLQALMQLLSRLCEWPGFCVKLLQIPYLQGTEAWKKAEEVVHSHQEEEVTQSYQINGDRIGNRNVNEMISGEPSIPPFSSLHVDPSPHTYEDPDGTTQDRILFVLNNMTADNLETKFVELNSIVEDQNHQWFADHLVAHRAKTEPNFHKLYLSLLKLFGRKSLWAETLRETYICAFHSLNSEATLSPNGSTERAQLKNLASWLGSLTLARDKPIKHTNIAFKQLLTEAYQTNRLLIVIPFVCKVLGQGKESTVFKPPNPWVMDVVRALRELYLGADLKLNLKFEIEVLFGELSIDPKTIEPSNEIMNRLISVDETAESLMGLTTAERFENLSPNDISGVSGARFSPQEITSSIPDLGPMLVYPPANEMVNQARLQDIVRTATTRAVYEIISPVVERSVTIAAISTAQMIKKDFATEPNEAKVRNAAILMVKKTAGSLALVTSKEPLRASMTNYIRALSGDLPQGLPEGTIIMCVNSNLDLACSQVEKKAEERAIPEIEEIIEPELEARRVHRMTRPDSPYVDVSLSRWALTIPNPFRLQPSMNGLNQDQIAIYDDFARPRLSPTLAGTTQAGSTSDATRSMTSEVLQEQYPTISTISNTAETPALPQLNNQPQPYLQSNPVLTNGRITSLFPDPRILIERVQKTLIELERLVIEASEEHYTDLIRPHPVIDILDVLYNLILRTSQSPDALDIFIVDQICNILFGGTDHSLMIESLVHVLENICRIGGRTASRVALMIAHQPAENFWRVPLTISLIKTEMIDWHRIDSETSKAIIQRREEPLKFLSSLVDAVLLHDRPIALFSDLASSLEAAWKWTDENPSLEIGQKLKDKLIASGMTKDIDRNIGDSQNFRRDQMEYVFEEWVHLCNNSNASDQAVVQFITQMYNKQLINNRDDLCIFLRLSIDISVDRFEQQVTSNGNTNGAYVSIDSLAKLIIMLIIRREEEWEVQADKAAYLKTVLSLLVLVLNHHHVMRGENFNQKVFYRLFASLISEFNIWSSKIPAREFQKIMLVLPKIFLDIRPSYFPGFLFAYLSLLSHRSFLPVIMGLPNSISWEPIAEIIVNLLSYVGELLKSLHISPVSKEIYRGVLKLILIFYHDFPGFLAAYHTRLCTNIPNHCTQLRNIILSASPIIKLPDPLQKGLKLDRIEEMRDSPENMDDIEVPIRQVGLLDVINQTLQSGPSEDAIAHIAHAMQGKKNYITGVGFVPINTDLNLISSLIIYICMYSINNSNAKDRPSFSALSPDVALLSMLIHELRPEARYFFLSSIVDQLRYPNSHTYYFMQVVLDLFSKDANDQEELDIRQQVTRIFLERMICQWPQPWGLIVTIHELIKNEKYLFLELPFIKSAPEVCERFTALTIRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PER4</accession>
    <name>A0A0B1PER4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000512">
        <property type="protein sequence ID" value="KHJ35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PER4"/>
    <dbReference type="STRING" id="52586.A0A0B1PER4"/>
    <dbReference type="HOGENOM" id="CLU_008451_0_0_1"/>
    <dbReference type="OMA" id="PQSLKSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="777" mass="90107" checksum="16577B9A8F3B4ECE" modified="2015-03-04" version="1">MSTVKQRDLSEYEILSEIYSLPFPQVRQTHRNLTIELNEKQTQLRTIVGENYRQLLGTADTISHMNEMIRVAEDNLIRVSHACRKSAVNDLATGLNRFYKYQRTGKHIKNLQWFTILKALEAQVLTIGKLIRKHGASNDNENSLILAVKILAISTTLLKSIEELEYRRSEGDQQQVLCMKRKLDCLHQRLLATTEKALRVDAKNSHERIIQALTAYSLMKNSDIIDVLKYFLNLRENVITNYFNECSKNISTEVVKAITLFAWTLHDTPIIFSRALSENLSNLKIKPLLKDETLKKIEDLRFDEFEGWFSDYVHTFIPCIKHANLNRPLTETLLKAWEIKISKLLLQNLSNFMKSQLNLKTIIELRNKIFGTWIEEGGNIKNLDVSEFLGELRKIINECVFGIVQQRCEALRHIFEEITITVASWEPGVTDKQASLWDKSILDMEVNNGADLFKNSIIARTNGRNDAVLTVNSCYNTWRNLIDEVLLYIDQMKAQKWYNDYEDLEEDVKIIARCNMLNKEDPQSIQQQLDFELSRAFKIMHEEINNLLEVNEQNQNLGQISIFIFRIIRDIRSNLPPNNDIRDFGITLFDSLYDKLARIVIGDSLSAFIKFIEKQTIPGRVLWEGDPELTVQPSPAAFKLLYDLAIIMANSGQDLWTPNAIFILKELLSEELTSLWKKALEENLILEEISHNTENENEENLKSTSVRKEVMIQEYFDFSLILKQAFRYDNLNSNRLIKDLEELIITRGELNAAMQKRISESASDYWKKTHLLFGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF51</accession>
    <name>A0A0B1PF51_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF51"/>
    <dbReference type="STRING" id="52586.A0A0B1PF51"/>
    <dbReference type="HOGENOM" id="CLU_007207_0_7_1"/>
    <dbReference type="OMA" id="NLMGAGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="88"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="309"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="54810" checksum="274CA066B718704D" modified="2015-03-04" version="1">MVFTVRIAPTRAAKAANLLRTIQYTNPPSCPCHGENKSLPPSRGASNILMAKTPRDSLHSHGALKMSISSISQTKREREYAFEMAASAIRFGPGVTKEIGMDFKNMGVRKVCVITDSTVKKLDAMKQVVEGLNREEIEFTVFDKCRVEPKDSSIKEAIRFAKECQQDAFLAVGGGSVIDTAKLMNLYTCYPEADFLDFVNAPLGRGLPITKNLKPLIAVPTTAGTGSETTGTAIFDLETKRVKTGIAHRNLKPTLGICDPINTRTMPSAVHASSGLDVLCHSLESWTAIPYFERIPRPNNPINRPAYQGSNPISDIFSLNALKNTIKYLPRAVKDPEDYEAQSQMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPGYKHPGYDVNCDIIPHGVSVAVTAPAVFRFTGSSNPERHLQAAECFGVDISNAKRESAGEILAEAIAVFLQVLGDQPEGLRGLGFETEHINDLVDGTLPQQRVLHLAPGLAHELSEAREQLQMLFEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFR5</accession>
    <name>A0A0B1PFR5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01000410">
        <property type="protein sequence ID" value="KHJ35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFR5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFR5"/>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="725" mass="83133" checksum="C21B731C785D1AD4" modified="2015-03-04" version="1">MTGSSLKRPTTDTDPYAASYIYYGKDTHCTSSNFRPRTYSSNPGTSLDRSGLKLLVRRGSLDDTTSNPNRFLLNVPQTIQNLTDQEDTDYNMQITIEDNGPKTISLGTFNSAGFKTKEVRGTYMISNLLQELCLAREHDKRHIFLDELRLNENPVNRLTRLITEEFWRNLTRVIDGSAIQVAGHDPKNWTDDPRPRIYVPAGAPEQYEYYSKISRDRPEICLDVCLLPKKITPELVRDMNHKPGLLAVAMEPAVDHTTGLTTLRGVPFVVPGGRFNEFYGWDSYMESLGLIACDKTHLAKAMVKNFIFCIKHYGKILNATRSYYLCRSQPPFLTDMALRVFEKIRHEDGALQLLREAILAAIKEYYSVWIAEPRFDKKTGLSRYRPEGLGVPPETEASHFTHILEPYAKKYELSLKDFIKAYNYGEINEPELDEYFLHDRAVRESGHDTSYRLENVCANLATIDLNSLLYKYEKDIAAVIRTYFGDKLEIPVDFQSPNMDSNYIETSSSWERRAKHRKAAIDRYLWNEEKGIFFDYDTVKEEQSNYETCTTFWALWAGVASPQQAVKIVTFALPLFEVVGGLVSGTERSRGAISLARPNRQWDYPFGWAPQQILAWVGLQRYGYFAEAERLAYKWLFMMTKAFVDFNGVVVEKYDVTRTFDPHRVDVEYGNQGSDFEGVAKEGFGWVNASYVYGLSIVNSHMQRSLGALIPWNQYARATKTFPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG35</accession>
    <name>A0A0B1PG35_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000245">
        <property type="protein sequence ID" value="KHJ35816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG35"/>
    <dbReference type="STRING" id="52586.A0A0B1PG35"/>
    <dbReference type="HOGENOM" id="CLU_1134267_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="30564" checksum="DA2ADDE961C0CC8D" modified="2015-03-04" version="1">MSITLKTVPVEAHWSIDLVERYHALLKCSFQIISEELKDLKTGKDVILQMAIKAINDSAGPNGLIPTLQVFGAYPRMCHSDPPNPSIAQRATAIQKAMNEIKKINCKHLVNNALNQRNGLRTEDIHDLSLNSEVLVWREAKVGKAGRWDGPFKLISIENETCKLAPLSGPTDFRSTLVKPYYRDIRNYDNENNNNDNDSNNHSHYNDNDNDNTDININNSNDFNDSNNICNDRTLESTTQNNIETPLRQNLPRNRELPTRFRIPNVAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGC6</accession>
    <name>A0A0B1PGC6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative celp0028 effector like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGC6"/>
    <dbReference type="HOGENOM" id="CLU_084275_0_0_1"/>
    <dbReference type="OMA" id="AITMCIK"/>
    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="28130" checksum="B132C318CD661511" modified="2015-03-04" version="1">MYFFNSANFFFCSILTFGIAASVSGAATILPPLSQIQHEITAEELIITGRDGRIEVVSRKEYMANINNVPIATAEQHYSNFTIEEDKGPSPAIQKRCEKRTVFTMNPVETFLNWDVAMSSVVLAPPNNTASVNIDKGHLIGEKLSVSAGPALKSVKKFMGVSLSINYDRSWMTDSSVKYSFVIPPGKFGAVVSNPFTIRHSGWVDIGCIGNSERFKFSGDSYRDMVFMNMPWVEGVIGLCIGDTFPLKRCLGSGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGE7</accession>
    <name>A0A0B1PGE7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000075">
        <property type="protein sequence ID" value="KHJ36310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGE7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGE7"/>
    <dbReference type="HOGENOM" id="CLU_036637_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="32364" checksum="ACC0C5FEC1A60695" modified="2015-03-04" version="1">MLTNKSLSKKRYRQEAEQHAMGFGERRMKRQNSAYVQQKSPILNLHSLSSYATNLNCPSSCAISLTSGESDVMSSYAQSAICVPPQLSPQSTISLLHSSPIISPLDNEETSHSLYMTQDSESEIYDTIYLSPGSIYNEISISTCNRIPTPIYSSFNLFEKADISNIKTIDVSGERLIKRANRATILHSPIKEEHMSPSIIVAGLNEMQVSEEKLIQLKEREKETKSTSLQSKSDLDTSMCASEGQNSENIKKIFCMGYRSNCEKCKMKVPGHFSHVILSKCDQKESLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGH6</accession>
    <name>A0A0B1PGH6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hmg box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000062">
        <property type="protein sequence ID" value="KHJ36345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGH6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGH6"/>
    <dbReference type="HOGENOM" id="CLU_046160_1_1_1"/>
    <dbReference type="OMA" id="DAFSHTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="5">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="32701" checksum="D46EF0FA019CCF13" modified="2015-03-04" version="1">MAPPTGTIPPELPPSVEEAYRAKCIQLKQRLNEIEEANDGARARISRINRGIQKSRLERAFLLEQLAKRTSTHVEDSEGSPSPPPTPKEKPLRTKRGHRKPEFMNPEVSESRSANIVSTQGPATVSPSSDAFSHTHPESLQNATPQAHSQLSKRQLSNNDTSTPTISRKRERASSQNKSIKGAFEIYCNETRSFFASENRKEISDGSFNLEAALVRSWGNLETSQKNEYRLKYEKAKNSVDKTRTVHEKGTLKQEGDSHLVEEGDDDDTEMPDNVNTPVVIPEISGFTPVNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGK7</accession>
    <name>A0A0B1PGK7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000170">
        <property type="protein sequence ID" value="KHJ35996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGK7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGK7"/>
    <dbReference type="HOGENOM" id="CLU_303488_0_0_1"/>
    <dbReference type="OMA" id="FGPAFPM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="657"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="814" mass="91282" checksum="A3F093A880BCF0C6" modified="2015-03-04" version="1">MLVGLPRGMDVAATYTPLECLLVFRSLVALGTEEEDFISISELLKKSPLVRDCPTYDAKRLEASALRDLYLRLLRDELRSEEQNGIEDTNKSPSRKRKLPSPKLASFNDCRQYKHKLPLLVERLYGRYRDYMIKAIEEDERKYVKLQGQIKKIEKEDWDQSMLEEDEDLESNDKSEPIPPKNVVLLESSNPKHGSNVSRKPTLKLSSSDETRQLELSHNCNLNSFECNSFPKTKAQKSRTGNQTALGQKLSLQKQLPLSNSSSQNQKELSKDNLYRTPGQISPPPYVYPENNASQLTPQIHAESPQKPSSRSPAVYLSQNSSPLASSTSKNLRNEKSSSKPTKIPGKTVNVHKNTFNQELHTSSEKQLTSPCKNTPKNKISVPEKSPSPFRNNQHDKDKTLPFRSSKTSPVFPETKQLSPSRPLIKPKKIYTSPYDKEKAHKLLTPIQISSLNLNKNKVSHKAISTEPLPPKNKKSVTGYGTTWNPTPTGLTPRNFTPLSPPKMEPLSPIDKPSGLALIENILEEKFQERESSCPLKSPRNDSPCSSPSKTDLEIAFTPCAGQSLEIPIANKKPLVNNPIDSDVEIKFNTLPKPQSIDNTTADKVTAREPSKNLLSPKSPSKLKQETQPFNKSQAPATVLWTRAFPRIAAQALQDISTDKNASMFANPIKEKDAPGYRNIILRPQDLKSIRIAITAGHRAALAAAPDDLKSNATSVWLPISEELIPPKGIINYAQLEKELMRMFANAIMFNADPRRGFVPLWQDAAERYKEGAFGYSFDEDSVVKGTRDMFAAVEKKVSDLRSVERKREKSWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHN3</accession>
    <name>A0A0B1PHN3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative duf500 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000083">
        <property type="protein sequence ID" value="KHJ36286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHN3"/>
    <dbReference type="STRING" id="52586.A0A0B1PHN3"/>
    <dbReference type="HOGENOM" id="CLU_009742_0_1_1"/>
    <dbReference type="OMA" id="KHTSSIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="214"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="661" mass="73397" checksum="5288BB9D9F840B86" modified="2015-03-04" version="1">MRSQGLLRNNLSDYTTVSAKTSPNSTSPRDGYNLKKMRRVTSLLPSWENSSKTVSNNIFDKSWTWSDVKNLPSSTRLYSAGLAAELQLLTESNFSSDSNFSNVTEFENFWPSTLDKESERAARILYSFCKNGSHVDLDQFQDQSFYTTNNCQRSLMIIPRNIIQRAVGLAIFTASRAGLWVSGAGGSGVLISRKDNGEWSSPAGILLQNSRLPFAGGVDIYDCVIIINDRSILKKLSGSRSTIGREMPAFTGPLVEVGSCENEDTLININQPILTYLKSRGFHSNVSLDGTIIVGRVEENKRFYGSRIGATEILSGKAQSSSSEIKLLLETIKFAESRSDINEQALEQLAMETSPSETYMDSSRTSSFGIPEAEDPDPFGVLALERAGLEIRESGSRSRPSSTQFEYHPSPSSPIFARFNRRSIDTQISRSNRGSYVSCRTRTSIDRGTQTMNMATQTDESWTPNTSPTGSDYKRPIHDSSSEYNENDSSKSLFGPAVQLKTCHELQSNTSTHVRRKIKSTDHEAKSDEPRIIDEDDVDNLDLEDEEEPVIFEAASAQATVLQSAKKAGGGLVHIPRRGPPPPIPARSASRGTIDSSTLNALRYQFEKSEICNTHRNSCDDKFLKYSQIIPPNCTTPLPRWHKTFEENKFTRGLPNTPTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHQ6</accession>
    <name>A0A0B1PHQ6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5773</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000153">
        <property type="protein sequence ID" value="KHJ36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHQ6"/>
    <dbReference type="STRING" id="52586.A0A0B1PHQ6"/>
    <dbReference type="HOGENOM" id="CLU_000315_16_2_1"/>
    <dbReference type="OMA" id="AISFTHL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002881">
        <property type="entry name" value="Putative snf2 family helicase atpase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="596"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="951"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1132"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1132"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1174" mass="132321" checksum="2476E77828D82A74" modified="2015-03-04" version="1">MAFDIGSTKAIPGTPSVKRQKTSSGFNTTAIDKYACDESFTKIIPETPGHVQSNPLQAIDHLTMPSFVIDSPESLNYNHVQVPASSPFKAPNITAREDVPMPKISTIRNLSGHEPQDSSSNHKASSNNSKASGHTSNTNDFSLIEQETSQSMNSVDNEKDPHYQAGSSVGELQEQSPNLNNMKSNKGPTQQDEIESTYRFLSPHDRFRTIVQGSSYKDPSSKNSYPTSTQSHKFISKPLQNRVERSQPIKDILLDEISDEKMRTDICRLRSIFPSISIIEAKNSIIASNGSFDQAADLLAEGNFSPKSSPSNRVTISLVDDDNDTKSLISSEPEMKRTLKLPTQSIRDRYSSSQICLKNSQLTNPKKQKKRLVQGRRNSPNLRVSSKSPTIRYSSSPEHISLSDTNSENESFNLNEDEGLEARVLKYLNTCDISGLVELANISKELAEIMLAARPFRSLHVARTVENSKKLKSGKKSTRGPIGDKIVDTALEMFRGYEAIDTLVRKCVDLSKPLASEIIEWGFDVYGAQKNGELEMTSLDAELSDKESPKFLADTDDEVKSNSRKRKKVQFLKKPNLMAEDCVLKDYQIVGMNWLALMYRNGLSGILADEMGLGKTCQVISFLAHLVETGKNGPHLVVCPGSTLENWLREISRFAPKLTFEPYHGPQKERQTMADEILQNRNNINIVVTTYDMAAKKDDNKFLRRLRPDVCVYDEGHMLKNVKSQRYQGLIRITARFRLLLTGTPLQNNLQELAALLAFILPDVFKDLEEDLNTIFKAKATTSDSDHTALLSTQRIDRARSILTPFVLRRKKAQVLKHLPAKHCRTQYCALHNSQKEIYEGHLELARQRARARLENNRAIKTEEKNPLMQLRKAAIHPLLFRRHFDDEKVEKMADILRKKEPINFPSNLKREHLIAEMRGGSDFWLHQWCRDYPCIAKFDIPDLAWMDSGKVEAMVKLIKNYKQNGDRCLIFSQFSLVLDIIEAVLNTCRIHFTRIDGSTKIDERQSLIDDFRDDESITVFLLTTKAGGTGINLMYANKVIIFDGSFNPQDDKQAENRAHRVGQTREVEVIRLVTKGTVEEQILALGDSKLQLDGRVAGDEDSGKVEAIGEKTVARMLFDATELDLKLGESEIEDKADTKKAPNTEDKKQNGSRKKNTILRLLTQKRDKVDVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI18</accession>
    <name>A0A0B1PI18_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g0067</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI18"/>
    <dbReference type="STRING" id="52586.A0A0B1PI18"/>
    <dbReference type="HOGENOM" id="CLU_009169_1_1_1"/>
    <dbReference type="OMA" id="HILHFAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="351"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="422"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="661"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ36436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="729" mass="80709" checksum="7BEF795D2831829C" modified="2015-03-04" version="1">MGFRLAWYATISTVAAGSVIISAFHQRSNFYSACVYLAQSNLCLMILTNLILLIYGTFVYSLQRVCFGPLRPIEIEQLYEKGWFAVTETCLAMTIFREEVGAWFLIMFVALLTGKVWGWIGDGRVEILGQQPPVNPRLFHIRLSTSLIMSVIYDLLMMNYIIKIVIQQARPNMMVMFLFEFAILTTSSLSTACRYGISLMEAKVIKMQTVERLDERRREVREERARIFRQRETNASTNSENIASESNAPLPSEDDVNEMDIEVPGWETKGQWVLTLDLVTDFIKFGIYTSFFVVLLMFYGIPIHIVRDLLLTARSCMKRLNAFLRYRRATYDMNERYQDATAEDIQREDTCIICREIMRPWATMNPQPPAAPAPNDNVPPARPSTSVNERNRPKKLPCGHILHLGCLKSWLERQQVCPTCRRPVVDSHGQSTRTVPNTGAGQGQPQPGQPDGAGGPQPARGGMRMLNFGPLRVGFGQANLHDLAGELGGPQAAPDNAPVGGPRVYGLELGFPRRAQAPQQPSGSTNMQPVLNLHEQLKLFETQILSELTALQLTQQEWQIINLLRAELERVRAIRNGIAEPISGNIGSSPVSQSDQSQSRAGPTFIPRVQAFQPSSASIIPSGHADLPQGVTIPEGWSLLPLQSIDETILTQSTRISPMVLNPTLNSIPVPDTNSGTDLSGSKNHTEPDSGLKNSPLNSSTGSASKNLKTPASSSSKTSSSVIEENANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI32</accession>
    <name>A0A0B1PI32_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000019">
        <property type="protein sequence ID" value="KHJ36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI32"/>
    <dbReference type="STRING" id="52586.A0A0B1PI32"/>
    <dbReference type="HOGENOM" id="CLU_025518_1_0_1"/>
    <dbReference type="OMA" id="MLAHYYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="456" mass="51706" checksum="A7A397F2EB655A1C" modified="2015-03-04" version="1">MNRQFGRLMRKDPGNRADIATLLSDYEEADKALSKMIEAFKSWRDSWVSTLSIQVAATALFKDLYNPITSGSDRHDAVPTVTPIEKLKKVVHLQEIFSDLKSDLLSEVKMIESRVIKPAIEVKEFIQPAKKSIRKRENKRLDLEMYTSRVNNYTKKMKRTERENVALAKAEEEVAEAACSFKLADDHLRDILPPIISSALSILPHLLRVQIMIQTTLLAHSYTALHEYCEEANFPFPSPSMPDVIKVWATEFNPIRKRVEAISCIARGKSVHQFIALEDDGSIIKSQIARNGIQDRRPSNNAIVSSQQSTSILGTINQHVPSHPEKPRNYSISNQNQHIESEPVRYDSNDMPHQNTTNSFNSLNFPVAVNNEQPQRSLVGKKRPPPPPPPKRKLSKEPQIYVTALYSFDGENDGDLSFKDGDIIMVTKKTNSTDDWWEGILRGQQGNFPANYCQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI71</accession>
    <name>A0A0B1PI71_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000115">
        <property type="protein sequence ID" value="KHJ36189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PI71"/>
    <dbReference type="HOGENOM" id="CLU_000709_4_1_1"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="710"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1137"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="879"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="960"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1313"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1330"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1357"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1371"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ36189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1733" mass="192239" checksum="73B0C9EB2C202111" modified="2015-03-04" version="1">MTEMLKPQLMIPIPPTPTEAKVEQNFSADFKEEREDLKEAAEQTPNVILDLSLDGIIRWVSPSWIDVIGTNPDTVRGKPIKELLIGENKDIFSEVTERMKIDKSRSQFIRFTTHLGPASKLANSYCQDYVIIHNVEDPNKNNLPVIELEGQGILVTARASDRQCQLNDSGGESHTMWMIRPWIAPCEIQIDLPDVIVEFLGSGAEVLASYLTTLAEAGVEDPASISPPPPVLCRICECQIPSWWFEKHTELCLQEHRAEMEIQLSQENLLEHRHAIVKVLDSLEAEKSGFVNSESPTHVPHQAEYKNIPIGFSSLSSSGLSSGTISKGIQSGRSRDLSTGGNNHSRRKSFAIRRPLARIVELLLDLCDTAIEISTPEFKESASKKLGEFRVQSPQSEGRISQVIQWQSPSTNTLDQEQGLALLCADTEKVAKAKVEAVIRYRRIIEYTERIRIEFSVLVQDCIDEAIRKAARIAAGYLTDSDEDEAETYEIESSAGYPISGQSNVRVARELTRDGQKYLSPTAKSSTRSSSPKESLVSKSQARSQSNFPHNPDFYRHSLLFESDTGGDSDCSVRSLSVMTRGTRNESPVSEIGDLRRAASSRPRQRRSIILPGSSSPRRQESPVRLPQPSSPLRINKPRSLVANHEGVASPVVSPMHNGSEFSSPALLPHHHRRQSSAAGSDPSRLPPSPRLSTVGVPQARIVPPSIKDFEIIKPISKGAFGSVYLAKKKSTGDYYAIKVLKKADMVAKNQVTNVKAERAIMMWQGESDFVAKLYWTFSSKDYLYLVMEYLNGGDCASLIKALGGLQEDWARKYLGEVILGVKHLHSRGIVHRDLKPDNLLIDQKGHLKLTDFGLSRMGLIGRQKRVLDSSLNDMTPDLLRQGPFARTTSISSSRSTSLDIQGNHSPSSSSLTMSENSLTTPSYFNLNRDGVSKKISRRTSGRSDSGDTLLQIFSSFSLNESDSHKQNRQQLSTEEQFSEHDSSPHDFITSNQIDNTRNYESRNTSSATSMMPPPMALFDPDDSNRRFVGTPDYLAPETVKGIGQDETSDWWSVGCILFEFLHGYPPFHAGTPDEVFENILARRISWPEEGNPEVSNEARDLIDKLLCIDPRQRLGANSNDEFECGGDEVQAHPWFRGVAWDKLLEDEAQFVPAPQNPEDTEYFDSRGAILQSFAGEIEDQASPEASSIISKYHDRPHDALSRVRSHVNLIKRNMMPLHIPPHVRDLKSRRLSEPAVTDDFGNFTFKNLPVLERANKNVIQKLRAEALASQGKSASISNISCSNTAISPGGYVDVSPIIPNPNQRNISCTKGSSARSSSPSAFSQANTSPHRTSQPSSPLLVSFVASQSAENRRKTSSTSSSLTHNSLSSVVQPNSSEVPRVSSNCQKPLSTVSSPIKGTCTGPTLPLQITSHQKIFSSIQHKDFSRRTRSLTVESQESGSSLPLEVVAIHKNRRSQVFEISPSSSDTEGDRESALLRVQRRRQSSRRMSQITASDGPFYRPLDVLVCEDHPVTRMVTEKLLEKLGCRSITVSNGAEAVRFAMSEIKFDIIMMEFKLPQINGADVARMIRDTKNTNSQTPIIALTGYLKELQAPHQFDALIEKPPTTLKLTDVICRLCFWKPPAPGLEPSRSLRNRRLSENRLITSGIDEGPKLEIFSSNPMLQSSPKEYCCRNPAISSGLAEKEGFQLNEQVPIIINRKATGDWEEATGLGIRNVDTLSPSRSCTDSILFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUU2</accession>
    <name>A0A0B1NUU2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bzip transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004999">
        <property type="protein sequence ID" value="KHJ30142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUU2"/>
    <dbReference type="HOGENOM" id="CLU_834693_0_0_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="36576" checksum="E63A805F407791C6" modified="2015-03-04" version="1">MAKQINSVALKSEGENSMAENSQPGPKAGSKNRASRAGTRSVASLTPEQLARKRANDREAQRSIRLRTKTRIAYLEQRIQELSGDRDDRVIEAVCRRNLELEEELRYLRHLSEALGRPENGRTSEPMMFQGKNNMMYLPSITSISPRVSSLPIMTEETQSGLAPWDENQHQITYLPHWNSRVPSNEDAEAIAPFYSNGNTEELMPGYSNSSLVPHRLNHHPSPNGHDGGVESINSHTPPAPIPIPSSTVPSFNPRPDPLKSRSFPQSSNSPTSIPHSSAPGSQNDPNNNVTFTSGYPTDRKVIFSHSASFGAGNNSSCVGNNGADHMGLYENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV49</accession>
    <name>A0A0B1NV49_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004713">
        <property type="protein sequence ID" value="KHJ30227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV49"/>
    <dbReference type="HOGENOM" id="CLU_1533713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="19782" checksum="14808983FEF450D9" modified="2015-03-04" version="1">MHVRDVVGSQLCQLVPLGGTRRLDGATGLRICLPSVFFVRDCRFNGDGGDAIGEGEMDIGGIGGIGGGLLLDPHSTINFLNIFYKTFLPDYPQSAYLIQFPNPYHTQISPNELLVILATKVEQLLGFRDLLMRDWIRTQENFEKLNNFWKAAVENNMLEEMHGQYIYEIKMENLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVI1</accession>
    <name>A0A0B1NVI1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004455">
        <property type="protein sequence ID" value="KHJ30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVI1"/>
    <dbReference type="STRING" id="52586.A0A0B1NVI1"/>
    <dbReference type="HOGENOM" id="CLU_049943_2_0_1"/>
    <dbReference type="OMA" id="WIPRNCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="222" mass="25806" checksum="12100FE43B5C8C1F" modified="2015-03-04" version="1">MAFGLTQYERVVLLDSDMLVLQNMDELIEMELDTPQVARMGQRVFAAGHACICNPLKKPQYPRDWSREKCAFSSQHDTPLTAQTTGPRTDTDLPNILNTGLLVINPSTSTFNYIIEFLRSDTKLKVDFAEQSLLSELFHGRWVPLPYTYNALKTLRWRGVHSEIWRDECVKNIHYILTPKPWEEIDAEGKSVSKEPTHQWWAELNLERRNMEQKSEIPHDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW13</accession>
    <name>A0A0B1NW13_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004927">
        <property type="protein sequence ID" value="KHJ30163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1435430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21393" checksum="FF2D707B98C95240" modified="2015-03-04" version="1">MFQPDKNTSLQGFIREYQKRYHDLKEHSTISPETKIHMKNLLLFHLSYLEKECRKKKKSEGDKSTLGTQNINQKKVLSIENETDNHRHQLDTAADFHVSGIKDDYDSYSSFSQTVRVAGGGRVPAKSKSSPSRGAGVNSQHALHVWDSQEDSHNPSLRDXGLNRLRFYITLPSAPFFTKPPTIGPGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX34</accession>
    <name>A0A0B1NX34_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ccch zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004040">
        <property type="protein sequence ID" value="KHJ30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX34"/>
    <dbReference type="STRING" id="52586.A0A0B1NX34"/>
    <dbReference type="HOGENOM" id="CLU_015255_0_0_1"/>
    <dbReference type="OMA" id="VMEAIVW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="662" mass="73303" checksum="3FB2D36EC3A12A86" modified="2015-03-04" version="1">MARAQQYKFPPPPPPPGPPSSNSQIHQYGYSQPPRYQQHMQRGGGILRGGRGGRGGNVGGRGEFHGNVSYNIQHSSPGYDPRHPQQNQIPVSTSGFNNSPNGVPSPASYIGHQPGPNTPQSYLSNQWQSNQHISQHVPTQPVSMSPQNYHPNYAPQPYQQPHYTQQRPSYQAQPPSYGHSIPPNQSPHVAPHLTPQATSPQWQSPSQHNRTPYSNHRGLGGFNVGGRASYDSPAPLMGPPIRMGFDNDPGGGHITQVGNGFPNPHINRHSSSPFPPTHFRGYSPQDFSPGPQRSAVDSNSYHLSNKVKGGSSNFRGKSRGDFNQSQSRNRNESRYHQNGGQKSSSDSYQKSVTADSTGKKKKKRKTNTLGLTPNDIEHEDSDDDVDDVDEEARLVTLLGPDTPQLPTDLKIWLAERKKKFPTKAVREAAAEQLRLRRAQAYEGKIKKEEVKIKKEEGEEKFSKKIEGETKLEKQQRKAEKLRLELEKAERKIQEEISGSKRKRGNGDEGDADCGQVSDNDSDSSASSDSDDKPEKLSSHTSSLVRNPPPKAQLQRHCKYFSTGGTCGKKGKCRFVHDQEVRNQALRDKEANGGKMTLAQRLILNDTAKDDLTILKSIKYLKEKGLMPDQLTSVGPGYSDELQAKVSETSDDEDLNYKQEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY66</accession>
    <name>A0A0B1NY66_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003468">
        <property type="protein sequence ID" value="KHJ30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY66"/>
    <dbReference type="HOGENOM" id="CLU_1788257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="145" mass="16382" checksum="4C710B8DDE298777" modified="2015-03-04" version="1">MLGNLRNLQLRLDPIYQTQKALQDKIINGCRSIPEYCLACYSPAPTLEGVYDQLRSSIVTAIELSGKQFINQNIQTSSQFFTDRRYHGIKNNRGSFKYSNQQEKPIKRFVCKQPGCWSSKHSNQSYSPFDLIAGLGSACIGMLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY83</accession>
    <name>A0A0B1NY83_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003448">
        <property type="protein sequence ID" value="KHJ30933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY83"/>
    <dbReference type="STRING" id="52586.A0A0B1NY83"/>
    <dbReference type="HOGENOM" id="CLU_998180_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="31157" checksum="2C8E824492B30B79" modified="2015-03-04" version="1">MTFILSAAGKNSRDDDVLTVDDVFSPKGKAPLRPGEEDLCDKQELEWEKLPESSFDRPKMIRAVSEPRVMLDWSFFDWKPDPKSFLRGISYYFIYRETILLQLECIGYHSELKLTQLDELKLAAVIQRTVTIEIAEMIAGMKSGLSMIRLFENTFRRAGSIQIEALGAKLSGLRRRVRIAAVLAILLRDTSTGFNPDSPRRAFIGVVRETGRIALAAVVQALFSALRCVPTLLLTILVFLVLVFHSYQVFTAKCATGMTHDSTACPMSSVGAPLVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY94</accession>
    <name>A0A0B1NY94_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005645">
        <property type="protein sequence ID" value="KHJ30010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY94"/>
    <dbReference type="STRING" id="52586.A0A0B1NY94"/>
    <dbReference type="HOGENOM" id="CLU_000680_4_1_1"/>
    <dbReference type="OMA" id="WPESHAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="18421" checksum="8C4A0193B9776B0B" modified="2015-03-04" version="1">MAFRFVDDTNLVAWGRSARENCYTLELAHSKFLAWAKRYGAEFAPEIYQLIHFSRKRGSSEDLKEKIELEDITINPRSEIKVLGVLVDSRLRWGPQLANAAQKGEVAFNAQSRITSSVWGPSVRSSRLLYTAIVRPTMLYGSQVWGIRPNGGYLKVIMHSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYK0</accession>
    <name>A0A0B1NYK0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative v-type c subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002872">
        <property type="protein sequence ID" value="KHJ31462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYK0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYK0"/>
    <dbReference type="HOGENOM" id="CLU_014048_1_0_1"/>
    <dbReference type="OMA" id="HITWLEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="513" mass="58038" checksum="8E9C8117BF8CD0D7" modified="2015-03-04" version="1">MPNILNNLRSYTTYLARSNLYFNTKYSKSKQFYKSQRASLKTTSHIKSTDKSFCNSSSNLKPSNCVSLRLSTSKNVDFSRREIINFFKPYVHNLEINIANDNRILNVVILVTPSHITWLENDSVQTFIGQLFVNHTSNNLWEVNVTCACVDGLAPSNREISCGQVVNIFEGISVFLSTLNSKISNLCPALSSSSRQASKDDCCFLTFEHGLDKDTKYSFQVTMPLANTLFINERRSTLITSKWRIAKDCINHIQEPRFPLNTLAYIPITMRDFSLQISAKTLTAPRIIEKGFGNIVRKLRAEGQSSFPASRELERVVAEAHRMNTLRSNHCVWALVFPHEMLDMEDIETQFDNKTINDSKYLERMVKKGAKICRVLSGGGGWGAKEGLLALDPAFSFENTSEHVEKIMSFKSIEENQEMIMGNMAQEGYLIQFLQTSYENNLALSTPTSRQQGNQFVYGCQTADTYKPTSFDSPVYAIMPNLFGCVSETGIFLQSPHIGPSKIDIPYSYIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYT0</accession>
    <name>A0A0B1NYT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative upf0220 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003210">
        <property type="protein sequence ID" value="KHJ31143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYT0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYT0"/>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="18987" checksum="687EBA7AD08CDB29" modified="2015-03-04" version="1">MPLPEQRLWKFTRPDWVNSSTTRSLGVYGAGAMFSLAFYLLLDVAVWSHSHNNGSTIHVNFTDWLPFIFSSLGMLIINSIEKTRLSADSFSYSGSGVALKARVVLFLGFASLAGGMAGGIAILVLKYVMGEAVWPTIYMGIANVLSNTSVMLSSIVLWISQNMEDEYSYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYV2</accession>
    <name>A0A0B1NYV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003180">
        <property type="protein sequence ID" value="KHJ31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYV2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYV2"/>
    <dbReference type="HOGENOM" id="CLU_1518975_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="177" mass="19633" checksum="11D577B515887EF1" modified="2015-03-04" version="1">MPEAYEFERQNNSRLSELSAKVTALRGITIDIYDNARSQDVIDDTSNTFSSMGVSLKGSAGRLRRMATSGNKVAIFKLSGIISKSSPPRGAGVSAQYAVHVWDSQEDSQNPSLQRLSFIPAGLNRLRFYITLPSAPFFTKPPTIGPGSIELRALYFHKEPPMKVSCWRIWSDAGWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM9</accession>
    <name>A0A0B1NZM9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005026">
        <property type="protein sequence ID" value="KHJ30131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZM9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZM9"/>
    <dbReference type="HOGENOM" id="CLU_005070_2_0_1"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="426"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="919" mass="101753" checksum="5D9C880FE9EAB887" modified="2015-03-04" version="1">MATSNMNFTDRATKAIADAMGMAETNAHSQVQPLHLALSLLDPPRDDASDSSSQSLFRQVIERAHGNAQAIQRALNKAVVRLPSQNPPPEQMSMAPSLIKTLRKAHELQKTQKDSFVAVDHLIIALTEDSTIQQALKEGNIINTKVIHDAITQIRGTKRVDTKTADSEEDFENLKKFTIDMTSMAREGKIDPVIGRDGEIRRVIRILSRRTKNNPVLIGEPGVGKTTVVEGLALRIVNNDVPDNLAACKLLSLDVGSLVAGSKYRGEFEERLKGLLKEVEDSKEFIVLFVDEMHLLMGAGSSGEGGMDAANLLKPMLARGQLHCIGATTLSEYRKYIEKDAAFERRFQQVLVNEPSVSETISILRGLKDKYEVYHGITISDGAIVSAATLAARYLTQRRLPDSAVDLIDEAAAAVRTERESLPEALDKLNRKSQQLKIEIHALSREKDEASKTRLAQAKEDASNVEEELRPLREKYESERARGKAIQEAKIKLEQLKVKKDDATRIGDDARAADLQYYAIPEQEKYIKSLEKEKAAADAALSSSSNPDSGGSLITDTVGPEQINEIVARATGIPVTRLKTTEKEKLLQMEKVLAKIVVGQKEAVQAVSDKIRLQRAGLSNPNQPPSFLFCGPSGTGKTLLTKALAEFLFDDPKAMIRLDMSEYQERHTVSRMIGAPPGYVGHDAGGQLTEALRRKPFSIILFDEVEKAAKEVLTILLQLMDDGRITDGQGRVVDARNCIVVMTSNIGAQFLQRPMTKQGKIDDTTKSLVRKAIEDYFLPEFLNRISAVIVFNRLSKGEIRKIVEIRLDEVQKRLSSNGKDVRIDCTPEVKEWLGSAGYHPSYGARPLARLIESEVLNRLAVLILRGSIRDGEVANVVMENGKIKVIANHDIQEEVYSEEEMEVDDVVELNNADDMDLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZT0</accession>
    <name>A0A0B1NZT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002527">
        <property type="protein sequence ID" value="KHJ31862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZT0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZT0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="329" mass="36726" checksum="6CB5A6B3240E30AB" modified="2015-03-04" version="1">MVQKNNMQEVNRNKESQKVSHRDNSATSVSDKRLFVRLPQDHEWRKRSPAGIREVIVKKLHISPSLIGRIKPVHSGFALSPCSAEAREEILKAENGLFLSGAKLETATNWVSVLVPTVPAFVKMEQGVVEVSKDMLPDEIERIFSMRPAHLKLYGRNNLEAPHRTWLAYFPKATRGGFRVFDESGVVRPYKKQKPIEFCKRCNGHHPSKNCSRAPSCANCGSTNHTADICMAATKCRNCGGPHRADSRRCLARPTRSGAPTKEQLKTYRQMGEREYNAVQRAKVAEEKAASIDRTEIDLTGSQASEVSMTIDNSQATPVEDTTTVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZY4</accession>
    <name>A0A0B1NZY4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iron-sulfur cluster biosynthesis protein isd11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003900">
        <property type="protein sequence ID" value="KHJ30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZY4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZY4"/>
    <dbReference type="HOGENOM" id="CLU_120076_0_0_1"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="103" mass="12412" checksum="D3EE9731F8A5E06A" modified="2015-03-04" version="1">MSTMNCLKRGEPARQARSLYRQLLRVSQQFASYNYREYAMRKTRDSFRENQDLRDPAKIEELFQKGRKELTTMKRQTTISQFFHLNQLVVEKDKVDSNEETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P099</accession>
    <name>A0A0B1P099_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004576">
        <property type="protein sequence ID" value="KHJ30286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P099"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10714" checksum="C45404D5EC31972F" modified="2015-03-04" version="1">MAATKCRNCGGPHRSNSHKCLVRPTRSGKPTKEQMKTFRQVGEREYQAVLRAKAAEESAASAESNNIDLTNSQESEIDGNIDNIQASPIENPTGGASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E1</accession>
    <name>A0A0B1P0E1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003663">
        <property type="protein sequence ID" value="KHJ30755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0E1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="OMA" id="AWHPRLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="524" mass="57431" checksum="E6A4851BE036B795" modified="2015-03-04" version="1">MAGSMEIFTESQAPSTDTSKQPPPIHNPPIIIASPPPPTNNSDAANTFLPKELAEIVANRQRRERAWHPRLMLCTTVISNIDSTLENITDDIEKEEAFALKAYLQLAIANFAAVDTSPAPSQIPSYSRPTKFSSHGSGKYKTTAKEVTVAIPRTIKGAVTSEESTQQAHKLPKPPQLNERTWATVARNGQKKARVTLSMKTQAVPTSKATQRVTNKRNSITTAPTDQRLFVRIPQEHEWRKLSPAGIREIIVQKLSISPSLIGKIKPVDSGFALSPCSTEARQAILDAGNGLFLSGAKLEPATNWIPVIIPTVPSSIRKVQGQVEINHLMLTDEVERVCSMRPAYVKLYGRNKSEAPHRTWMAYFPKAPRTGFRVFDESGIARPFKKQQPLEFCKRCNGHHPTKNYSRAPSCGNCGSTNHSEGLCMATTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMKAFRQAGEREFQAVLRAKAAEESATSAKDFSVGKISSQTTEVDANANINTASPVDSSMGDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I4</accession>
    <name>A0A0B1P0I4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004529">
        <property type="protein sequence ID" value="KHJ30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0I4"/>
    <dbReference type="HOGENOM" id="CLU_064433_0_0_1"/>
    <dbReference type="OMA" id="QWAALSM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40049" checksum="88D4199256F8DB59" modified="2015-03-04" version="1">MDEIPIAGFKRLQDQLLLSLKDPETCLDEKLIDEVQVQLTAEEIIPIARPRLLPLLTKILPSYPKNPKLLSELSQKLLRSVGFRQVLDFASEENLVLALKSPFPAANLLGIDIVSKASWAPSHTTILSNMKPLILAFIQTWLCSPDVAVGEAATQTLGDLLEMDCDCRKALSSSTSTRVKNLNVSSEIPLGQGLLWRRIFQDQDIYNQLFSLCDLNAAGKEDCCMERRQISIAQGRLLQLLPRLATFNFQIISQSQFPMVEETYIGQPSGILFYAATKMINKNDLLMHMILITFFGDLLSMLSKETISPSDFNYLSSLLNQVAHEDISLKESIEESVRNPETAPELLELLSRLTLNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P126</accession>
    <name>A0A0B1P126_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gastric mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002459">
        <property type="protein sequence ID" value="KHJ31933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P126"/>
    <dbReference type="STRING" id="52586.A0A0B1P126"/>
    <dbReference type="HOGENOM" id="CLU_006328_0_0_1"/>
    <dbReference type="OMA" id="WKPVFRE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112358" checksum="F86D4A262FAFCD42" modified="2015-03-04" version="1">MLNSRDSNVNGKLIALEGESKVISTHIRSLPPSRKILTFPTLQECISYVNNQEQFEPKSFIKNVHAALKQRLNVAHSFLQSGEPKQPRLVFMNGGTLRARTICIEGICKNLTAGDIGAAEALFNNLTRDGLSGLFTNEKEDTIDKVNEEVVTSDKSQIDNDNDNISLISSQIKVGELKMESPEKRSLAQEKYHHVTNSTSTMSSSFNQESLMTIRSKNSKISHQLLDNESLSNINANSINGDLVDRDKIIRTTFTLVSNDPAPSGSQVAEISPACLSPLTSTPSIPGAYLQDLKDESRNSSRLDLTFNDISFPSTPTTVERIKFTSKFSSTETPNRGRPEISTQSNEPLTAAQPSLSLGLDSKSKKRPRSIKMLDTDNFDYFSSIYSGDEYRTAQSIDSQNSDFSPDILANERHRYVDRGCNTEEPLNGKKAIIEEFNMPIFEVVEDIIIHFADSSTNTIYNNVLCSYQDANFSSHRPTSWSVNVKTSKRHSELSPRPKTSYPKEDKFHSQDNVTNVPKLIKLGSQLNNSRFLEADDFSPPTPALISAKIRNPNDKSKTKFLTFSAANSSNFISAHNCFRRLLSSHLPSGKDGYSQYDQSVASQIDRIWKPVFGNWNISECVLKKTTIDQIIALGCGNGGEEDFSQISGMVERLGTKKSGQSRSDKIDISYLISNAMQHMNAVPFNQQTTDPQPESSVIANLLVPQLESYFAHHSSVQFLVLHFSSSQIPIVFALRELLGSTLFKIAGIPLVSNVNLTQFPSSPTSPNPLSNESVSAINENKTYMMKKNENCSPSLSSVAYSVPPSPSTVSDLDVQESFSGADFILSDISSNEEITRFISDIRQILLEKSNFYVPEPEPEPRTIVQVVEKYISAPPVPVTRPSSQHRSSIMEGSVQDGVYKSNSRRQSCKTNRYSNNGIHTPLSEFIAKRNYAASIASSRRTYASSISELEGWENFEIGDDESDFDEYDRMILGSKMSALILGKQIFGAGNQNEFSQQGVASKRKALKWLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1G5</accession>
    <name>A0A0B1P1G5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003675">
        <property type="protein sequence ID" value="KHJ30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1G5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1G5"/>
    <dbReference type="HOGENOM" id="CLU_010106_0_0_1"/>
    <dbReference type="OMA" id="RTNQFEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="552"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="961" mass="111822" checksum="47A7A94D71C65E82" modified="2015-03-04" version="1">MTYHIEIETLLDELIRLIASPSLQSHPKKLNTTKDYALHVLRQQNFARTNQFDVESQLNGLDEKFRIYGRDKLADALIERRSILYKNETKFTSEILHFLLEISHRPVSDLEYKFFDSPKESNTSNDLPLQWSDVLDKETLSKEKEIWENVNFVDTGSDDEYEFEITKLVASENNSSLDNRPKAKTKNLQGIIFLNSKDNDGLKILRESQFWQKIPNVNGIRMETIKKSITELQAIREVLFMLGGYPTTLFKINSQTSVIIEAAKDYALKHVSHDCFMNILRTLASQGTITIKLRLWVKSSQVNPLLQAFQLAILEWLDKFDVLLSEIHQRFLSPSNNTVVSLLKVWQEITPTVSFLTHLVEITRIIEQEPNQHAFLYLEMLYNLTCTSQMAGDDAIYSNIGKVFFHCFLVYLRPIRAWIEDGELRKDDPNFFVRESIENVELSSLWETRFKVRKTKDDVLHVPCFLRHVAYRIFNTGKSIVLLKYLNQASLLQTINRSMEPPLDFETVCKPATFQLVPFMELFNISFDAWVSSKHQYAASLLKDTLFNSCGLHASLDALSHIYFLADGSIGSLFVATIFKNLDNLKTSWNDRFTLTECARNKFSLVSSVLSERLHMSMSSLAQNHQNLKKSRKSVKVFTAIELKYQLSWPIQIIITPMAMPLYQRIFIFLLQVRRTSEILTRETSQLDRLNCIYEIDEKALYYSLRMRLIWFTQTIYYYLTSLVLEPCTQKMKTDLRAAEDVDMMINVHVDYIKKCIDQSLLGKNLEIIYSTVMNVLDLGICLRDARLNNDAVTKFTLNERNSLMDLSIAGLGLYTTNHHYRQQEHQKSDIRSPRYNRRHYTYNNNNNNNNRKWNDDSSSDDDYSYYKKIKKKENNLEIIDNDLSILRSPSKLSSDSFEDDNDHISVFPYISQLRHLKATFNRHVRFIANGLKGVARATTNSEEARLWDTLSDMLEIGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1N2</accession>
    <name>A0A0B1P1N2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1N2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1N2"/>
    <dbReference type="HOGENOM" id="CLU_013601_1_0_1"/>
    <dbReference type="OMA" id="LQYGPPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="568" mass="63643" checksum="CB76CD9501653588" modified="2015-03-04" version="1">MERKRKLPARAARADSVSKKKILKTSALNAPTQTSEPQPVVFNERTPLPTSIVSGKLLPTVSRPQPTDLSLKDYQSIPERQAKISFEYCSSLKANLASGVLSESLHRSRQKWTSEGIFEKYWTKIRKGKNTQGEPPGNPPKDSMIKLGTCTIIVEPHIFDATLYTVKVASPRIADPKVVPMSRPVLQYGPPNTDAQSESIIKSECTSYKPPETNSLDMNKSETKLVVNDQETHIASSNIESNSSKPNLNTNSIKCNKHPENTKVIPATEIKPVSRSADPVIQMLAQRAATDADLQYLMGKVANGQATTEQLKKFQCHINEVTTIQLERKEQQRLKKDSSKTSSTCPNGSVTAPPKILAQTQSSIVYSSDTTQPSQNITQSPAIRPEESLNSNKHDVASVVLEFSNGNGDRYSFPKYSILEFIPSTNQVIVSFLIIRKGSDAESPSYNPKLDYYQPMTIRLYVHQTRLLDALQKAVETPDKVREWMNKVMEECQRAEYVLLAMRLPREINYSNSINMENKFEKNNHMNAQVNWKTTQAPQAKTKVKSPKKMETEEAHYDNYIKSIAAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C3</accession>
    <name>A0A0B1P2C3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002077">
        <property type="protein sequence ID" value="KHJ32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C3"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="389" mass="43126" checksum="68FBBD4B1E3EDC5C" modified="2015-03-04" version="1">MNTKPRQTKDRCQEKDSEKNNPLTSLYKPPKDTPGQNSWAIVARNRHQKSRVTTTTPLVSKNITTGDPQKPSTSSKSSMNKNIKSKNAKEISPDSRLFLRLPADHEWRNLSPAGIREVIVKCLAVSPASIGLIKPVRTGFAISPSNSGAREALLQTKIGLLDTGTKLEPASNRVPLLVPTVSKFIRTIQGQTEVTKEMLSSEIERVTSTRPTSVRQYGTSVPKAPHRTWMAYFDKAPHPGFRVFDESGRVTVLKKQKAIDFCKRCNGYHPTRYCSRAPFCGNCGSFMHSQSDCKAFTKCKNCVGPHRSDSYKCLARPSRYGGPTKEQLKSFRLIGEREYQAVARAKVAEQRATAVTESIIISSSQSPESSSSDIQQIPIKASVGEQMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H4</accession>
    <name>A0A0B1P2H4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001766">
        <property type="protein sequence ID" value="KHJ32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H4"/>
    <dbReference type="HOGENOM" id="CLU_2470744_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="88" mass="9640" checksum="58E4A9715DEF9778" modified="2015-03-04" version="1">MIFITVISNLGSTLTRITEDIEKEEVVAFNTYIRLAKGHYAAVDSRPGPPNIPTRSQPTRGNGSSSSKEKRASEQVALTITPNVILRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N8</accession>
    <name>A0A0B1P2N8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003462">
        <property type="protein sequence ID" value="KHJ30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N8"/>
    <dbReference type="HOGENOM" id="CLU_1483049_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20255" checksum="4B9D31A7C8E56C0A" modified="2015-03-04" version="1">MTGFAFCSSKGNLEAIKNKLAWRKKKRMEMEKMENKSKVSNKSNANDKTLCVNNPENSSHQLDAAADCHVPGNISDFSEYSNFPKIVQVAGGGQITAAGYGTLALQSIDKRINNLRGAIYLPGQRQCIISTAQLQKQGFSIRWLSNYHDIELLRSNGSICAIFKRVSGRFLYKPIPLVLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Q7</accession>
    <name>A0A0B1P2Q7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01003125">
        <property type="protein sequence ID" value="KHJ31201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Q7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Q7"/>
    <dbReference type="HOGENOM" id="CLU_044237_0_1_1"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="203"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="35768" checksum="F8F42EEFD4E80F04" modified="2015-03-04" version="1">MNCKLAVAPKFTKWEPSTIFSDTPLDKFALVILNRELQLPISVYSRLWANAVYKVAADGGANRLYDLNKNTCNNISDNASPPFLHLNCIVGDLDSLRPDSRAYWVQQKVPIIHYPEQDSTDFAKAVYHIRNHFIGQHENKEEENQKSIDIVVLGDLSGRIDHAMSILHNLYTLQEKVDEENEYLAGRLYLVSSEAITFMLQAGTHKVEMENLERNQLFNHNNNQNSHINNIKDNNDLVKINKHVGIIPLKESSIISTLGLQWDVANWETQFGGQISTSNYIINNVVSIQTSKDILITLELDILSHQDETQHIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2R6</accession>
    <name>A0A0B1P2R6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001696">
        <property type="protein sequence ID" value="KHJ32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2R6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2R6"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="OMA" id="CTHARNT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="457"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124797" checksum="8AA7E86A82401573" modified="2015-03-04" version="1">MLNPKKHKVVALQEPSLNPRTLDTYCPRGYILCMEPTLETKVAFLISRDIGVANWTYKWYSNLVAEIKLSFHESLLRIVNVYSPTTSGSELTGWDEITEAIAHDRGSCLFLGDFNCHHPMWGGHGAQRDTRAQQLLNYTLGNGLDLITPEGIPTFRRNGARGTIQETVIDLTFATGDLLKSIHACRPREDWCIRHDHIPIEIILTTGQMLNLERRRYVYHKANLEKMKSMIRECKWEQAQQPLVALQEVIIQALNEHCPRAHPSPFAKPAWSAKATELVANARSSRRQALATKEDHDVTRAKLIRQELKKEIRRLKRSSWRSFVASSTDTRGNHNRGLWNLSKWAKKSTNIVQGPPHLPGLRRSETDPPTDDNRSKVAILSDKFFPKRVEADLSDMELIQQAKRHTIAIPDVTPDEVGRILKQLPRNKAPGPDEIPNEILQALLYDWRVDLAQAIRSLLRNGQIPSSFKESITLTIRKERRPDYTLPSSYRPIALENSLAKIVEKLVANRMIEAAEQHNMLPWAQMGARKNRSTISALELLTSTVQTAWEARPSRVVSMLGLDIKGAFDNVSKRRLLWGLKREGFPDWVTTYIENFLSHRRTKISFAGHTSDWIQTEVGIPQGSHLSPILFLFYISELLESLQQHENNYMAFGFVDDTNLVAWGRSARENCYTLELAHSKCLAWAKRYGAEFAPEKYQLIHFSRKRGSSEDLKEKIELEDITINPRSEIKVLGVLVDSRLRWGPQLANAAQKGEVAFNALSRITSSLWGPSVRSSRLLCTAIVRPTMLYGSQVWGIRPNGGSLVKSLLGKLEKVQNKCLRRITGGYKRTPRAILEREAEILPLDLYIQAGTFRYGATTEHKPVITEILRHINLMWDLFSRSYKRRATVTRKATAMEHNRHEARSKMEELNTTVRPRNLISQLQGSGIRNQDSRPKAVFKRWAEAHWKQRWQEMRKEGTIATWNTPWHKHPLKFYDKLKKHEATALMLLRSEVIGLNAWLARIGIPVVTPRCSCGEHAQTVRHILCYCPDHSALRSHMLLQAQTRDFSQLLQTPKGCRAAARFLIATERLSQFKIAGKIDHEVLDLAKIPELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P310</accession>
    <name>A0A0B1P310_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquitin-protein ligase sel1 ubx2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001899">
        <property type="protein sequence ID" value="KHJ32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P310"/>
    <dbReference type="STRING" id="52586.A0A0B1P310"/>
    <dbReference type="HOGENOM" id="CLU_007931_0_0_1"/>
    <dbReference type="OMA" id="MDLQARK"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079683" evidence="3">
        <location>
            <begin position="26"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="826" mass="93020" checksum="11690827EB4E8D00" modified="2015-03-04" version="1">MRNWTLNLRVLFIFFQSFLIIFTKSQESNEVIIDGDKSSKPSIALQSPISQSQPPILEHKDLSRKDYGSEQVKKAINYLEKYNRHSPQTPRKHSGVFGTAGQYLQAFLPRLYIHGLPSDGLQDNQKLPGQLGDAVRLLEEAAQQDNPDAIYILAEMNFYGNFSHPKNYRQAFTRYYQLASLNGNSSAQHMLGFMYSTGIGGAVERDQAKALLYHTFAALNDNVRSEMTLAYRYHTGIGVAANCDIAVQHYKKVADKAIKWIRSGPPGGMVWVSDSYRLADENGGVYGEGASFSSSGNNRNKNGVHSDAHAALDDVLEYLDLMSRKGDFKATFGLGRIHYDGQKGLPRDLKSAKWYFMKVAKLYWQRDGRIIESEKPGLEKVATKAAGYLGRMFLRGEGVEQSFDKAQIWFQRGIKSADAGSQWGMGLMLLEGLGMPKNTVRATEYFKAAADQDFAPAQVSLGALYLDQGTPGDILVATRYFELAERYGNLEAYYFLAELINQGIGRDRNCGLASMYYKNVAEKVEPLLSSFTEANQAYISGDYELALIDYMHAAEQGWEKGQANVAYLLDDQKSLLNLPKWLSFSRPRPKLLEDGALALLYWTRSSKQSNIDSLVKMGDYYFKGIGTPADMEKAASCYTAACEYKKSAMALFNLAWMHENGAGLDQDFHLAKRYYDLALETNDEAYLPVTVSLLKLRIRSAWNTITNGRVNSIQDEPTINKQWSPSEWISNFLREENRYMRDGELEENFLPESNPMPVGNTDGLYDDNNEDGILESLIILGLCASLVFLIWYRQQRLQRQQLQRREIAEVQNGGVAAPDQRGLFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P420</accession>
    <name>A0A0B1P420_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001434">
        <property type="protein sequence ID" value="KHJ33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P420"/>
    <dbReference type="STRING" id="52586.A0A0B1P420"/>
    <dbReference type="HOGENOM" id="CLU_003094_1_0_1"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="10">
        <location>
            <begin position="266"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="811"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121292" checksum="0540BCD72C9E9A98" modified="2015-03-04" version="1">MLSPSSRRSVDSLSPTSPKTVRSEFFPRAGVGRFQTQRGSIASSANTIGGKLDAAANWHGLAESGQNSIFTLLQSPIVRSGSIVPNSVLISNAFKAPTTRDIPPVTLSPIPAYDATVLTPYLSQVGALHGALQSMKESEEEYGTLSSKKPSQSDGGTEGFDRIMRFSGSARSSISRPPSISNSNESPRKRSAAARRAALATAPLTTIPYVFFEEEFHLENPRTFDVVSERSELVKPVQTSTNGQKSLSTHDFAPRKALASNAILQEKLSWYMDTIEIHLVNSISSASKSFFAALGSLRELHQETSISINRLKTLRKDLLSLDEDMALTGLKIVNMKQRRENLKQLSKTIIQLQTIMEGIKNCKYLIEEGDVENALDSIDSLENLASGKDSSNSDHVSAYDLRKVGSLKNLSNDIGELRYRIGKVFESRFQNFLTNDLKQYMDSVSSSDTLQRWNLSSQRSRGHHREHSSPPYMTVKAEFRSELHSVLTGLYRTRHISPAITVYRESVLREVRKIIRRQLPASSDDDMESIASASTVGGNKPRTQHEKISILARNLRSLEPEESEELLKRIYIGIGETLRRIGTQGKVLLDITSTFGENTNSQNSPQNLNIISHGERLGISSSKIVVNPDTQDEMHLSLNISDLVGQAVDTAQDKIMKLLRVRSEQTNRLSVENFLRYFTLNLLFANECEAVSGRSGTSLKNLVNGHIKDFTRQLGESQRQSLATGMEADTWNAKDFNEEDNNVLSHIISSRNQDVEAWIAGSYVWIKSSSVSNPDSEKTHSMLSAENIEEKYQNMPTQSKIVIRPAIIESESFLLPNSAILCLYGLASFLHLNTGIPSMTPEIASSILSYLTLFNSRCTQLILGAGATRSAGLKNITTKHLALASQALSFISILIPHIQEFVRRHSSFSSSSNATLLSEFDKIKREYLEHRKSISDKLVDIMAGRTIAHTKSMRSIDWSKERDGVNHYMETLTKETNTLYRVLSKHLPKQAVNQIMQPVFENYKEQWSKAFGEVSLVSEMAKERMLRDVEWFKDKMAYLDKSSTENDGIGDNKNDVNNVGVTLVNLVKDKEVILKSISAAVPALNKASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P442</accession>
    <name>A0A0B1P442_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002897">
        <property type="protein sequence ID" value="KHJ31424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P442"/>
    <dbReference type="STRING" id="52586.A0A0B1P442"/>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OMA" id="GDNPHTP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="27591" checksum="0A45BE1620E9E8DA" modified="2015-03-04" version="1">MASNPPSSCCIIGVKHEGNPAGKSINFDSIDAYIAEPSDPNVHPNTAILFLPDVIGIWQNSKLMADQFASNGYTTLLIDTFNKDPLSLDKPADFDFLGWLNKGSTGNNPHTAEFVDPIVEKGLAYLKRNGFTKIGGVGYCFGGKYVTRLLASGKGLDVGYVAHPSFVTEEELANIKGPYSISAAEIDKIFTTELRHKSEEILIKTGLPYQINLFGGVSHGFAVRCDLSKKIEKFSKEKAFLQAVQWFDEHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P447</accession>
    <name>A0A0B1P447_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002896">
        <property type="protein sequence ID" value="KHJ31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P447"/>
    <dbReference type="STRING" id="52586.A0A0B1P447"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="118" mass="13580" checksum="1B468A4C1215F6F4" modified="2015-03-04" version="1">MAHGFDMGIAIKTTMNAMLRREISMYLCTDSKSLYECISKLGTTQEKRLMIDILCLRESYERREITELRWIAGNTNPADAMTKSKACPALKNLIDNNYINLNEATLKWVERVQDRNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P471</accession>
    <name>A0A0B1P471_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002873">
        <property type="protein sequence ID" value="KHJ31459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P471"/>
    <dbReference type="STRING" id="52586.A0A0B1P471"/>
    <dbReference type="HOGENOM" id="CLU_076902_12_1_1"/>
    <dbReference type="OMA" id="DNYMNFQ"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="89" mass="10213" checksum="C8BC65C0A41E0DD3" modified="2015-03-04" version="1">MSVMPINPRPMLQSLVNEEVIIRLKWDQTEYKGRLVSIDSYMNVQLSGAEEWIDQKMTSVLGQVLIRCNNVLWIQSAKSSNGDVDIKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P495</accession>
    <name>A0A0B1P495_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6441</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P495"/>
    <dbReference type="STRING" id="52586.A0A0B1P495"/>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="22508" checksum="3D83F57F9A2B82E5" modified="2015-03-04" version="1">MKLHYIGIIKNETKPSHELVAEKDLSAYSRFTRNNYGEFMTLFSKTVAERTRIGQRQDVEEQDYTFHAYGRSEGICGIIISDHAYPALVAHQLLSKVLDEFLALHPKSEWSTSNPTLSFPALKDYIVKYQDPQQADSIMKIQKELDETKIVLHKTIESVLQRGEKIDDLVAKSDGLSAQSKMFYTQAKKQNSCCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4B5</accession>
    <name>A0A0B1P4B5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002274">
        <property type="protein sequence ID" value="KHJ32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4B5"/>
    <dbReference type="HOGENOM" id="CLU_906719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="307" mass="35688" checksum="2DC3EFC3C20EB4BA" modified="2015-03-04" version="1">MHRKGFDVLQVYKSDEIDQCLILESYEYDFNDFKQVDFERLDRDTIVKLRDTLRLKGIYVRKGAGIKIALALSERLTIDSKWPNEDPQRSLQRPSTNSKPTNTQCELQTQSTVKFRTPHLLPSPYQMVETFKQQQQGYGKELANLAKIYNIDEKYGDTSTESFNYKFNMFLDSCSRAQLAENALPLAFPVMLKLTALEFYYSSCQGFNLTIQQLIQKFQDQFEGEEYRRNALLNWNNTNFRTWLRHNTDLPKSTVFNKRIEHLRQIQRGLDQEYQSDSALRNKIITACNNVAACSLAVLQPATAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4G6</accession>
    <name>A0A0B1P4G6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001590">
        <property type="protein sequence ID" value="KHJ33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4G6"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="39312" checksum="1E9B0A14A78BD31B" modified="2015-03-04" version="1">MTESMEFSQESQAPSTESSQKPPPIPPIPPIPNPIPPIASSSFPSSPNTFNTTLDSRQILKHFAPAKRTLPEKPQDKSMNNSDIGNAFLPQELAEIIATRQRRERAWHARLMICTTVISYLDSTLVNFTNEIEKEEVVAFKAYLRQAIANFAATDSSPSPPQVPTHTRPNKGNGKGNVKTDKNITKKIAVATPQITLSRAVNRGSNKEVEIPNVPQIKDKTWAIVARKGMKKARVVSCNNTQASTGNKNASRVFDKDNSSKPVSDKGLFVRLPQEHEWRKLSPAGIREVVVKKLAISPTLIGRIKPVNSGFALSPCSTEARDKILNAGNGIFLSGVVRSKFGSSHQLGISLDTNSPSAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V7</accession>
    <name>A0A0B1P4V7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002431">
        <property type="protein sequence ID" value="KHJ31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V7"/>
    <dbReference type="HOGENOM" id="CLU_2110755_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="12324" checksum="5BFDA332F80C13DD" modified="2015-03-04" version="1">MPASRALARLENKGLAPDLIDIDAIESVIKQNDDLGIEIIDEEIDRLIAIDQESSCSTIKASTKRRAAQTAANTEVCTAAVNSVVATLAPLATGTQNNFVVSMKVYLRSAIAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4X3</accession>
    <name>A0A0B1P4X3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002125">
        <property type="protein sequence ID" value="KHJ32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4X3"/>
    <dbReference type="STRING" id="52586.A0A0B1P4X3"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="OMA" id="SIWDYSK"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="512" mass="54324" checksum="33F212C98F28B573" modified="2015-03-04" version="1">MHSVSNQSENVGEEDVEEETIMLNPSEIEEEITTDGDIAMDSGSESHDDGCDNDDNDASNSGLETLQEIQLQNDSVAYFDLHNDSIFCIAQHPLYPNLIATGGSEGDDDAGGMGYIFDASPEASIPISVTDQSAVPNNFVRQSIKPLFRLEGHTDSISALAFTLPKGKTLFSGGLDGKLRAYTANKHLDWIFLGESQEVEEINWILACPNESHPDIVALGASDGSVWVYFVDSESKDMPLQIIQSYFLHTGSCTAGNWSSDGKLLATVSEDGSLYVWDVFGDSAAARVIQVGTAYVVGLSALDQRFAVDGGLFSVAISPDGTFLAAGGAGGSIKIVSLPKLSSEKLDGLPKGRNEKQVKGKSNSNNVSIGHAGKILADIKAQTDGIETLAFSSLPTMLLAAGSVDGSIAIFDSAHKFNTRRLIKQAHEEYSVVKVEFVSNSTNEGCLLTSCGMDGVVRRWDTRGGSGIGLIQEWKGHRGHGEGGGILGFVQGNGSRIVTAGDDGISLTFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P580</accession>
    <name>A0A0B1P580_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001220">
        <property type="protein sequence ID" value="KHJ33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P580"/>
    <dbReference type="STRING" id="52586.A0A0B1P580"/>
    <dbReference type="HOGENOM" id="CLU_028132_1_0_1"/>
    <dbReference type="OMA" id="KNIMHTV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="198"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="416" mass="46761" checksum="986627CCBDF10A85" modified="2015-03-04" version="1">MVSAKISQALENISSSPDRYQEIGNLLKVVTSRDKTELTTNFSAIVDTIFAQNLGIVTTRSLLVAVGDLLRSLEDNATKIAVGEHIVKYLSHQVSSFEEQYIQILEIIATSFENNDDFLEAAKILARIPLESSQRKVTSEDKVKIWIRITRYYLEVDDTTLAEQYLNKAKNFIYAVEDRDLNLHFKLCQARIQDSKREFLSAAQGYQDISFMPIIAEEEKLHTLSMAIKCAVLAPAGPARSRTLGRLYKDERVSSLEEFGILEKMFLDRVLSPDEVAKFAEGLAPHQLAKTSDGSNVLAKAVIEHNLRGASRLYNNIGFDALGILLGLDSDKAEETTARMIEQGRLVGRIDQIKRIIWFETSEAAGEEGACISKEVACRELKRWDANVQSIAEEVEKVTTELQLRYPEFVSRHLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5E9</accession>
    <name>A0A0B1P5E9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001988">
        <property type="protein sequence ID" value="KHJ32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P5E9"/>
    <dbReference type="HOGENOM" id="CLU_002414_2_1_1"/>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000625">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000788">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="90"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="582"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1433" mass="157662" checksum="048E6592BF5D8F0F" modified="2015-03-04" version="1">MQCYTELTPPSAVTHSLILPLTSADSNNLVVAKTSHLQIFTIKTISAGDDSSFREITENCEINDTQINDTGVVESTTGEDSARSGRVRRTKLVLIAEYPLSGTVTSLARVKLQSSKSGGDSLLVGTRDAKLSLAEWDPSRSELSTISIHYYEQDDLHNSPWAPALKDSVSYLTADPGSRCAALKFGLRSLAILPFKQGDEDVHMDDWEDGLDESRSAEKSSTKTTNGNITKEETPYSPSFILQLPSLDSILHTPIHLAFLYEYREPTFGILASTNSPSASLLFERKDILTYMVFTLDLHQRASTTILSVSGLPYDLTQIVPLPAPVGGALLIGSNELIHIDQAGKVNGVAVNMFAKQCNSLNLYDQSELEIGLEGCKIEQFSIESGEMIIILQSGQIAILNFHVDGRSVSGLRIRPVSENAGGFLILAQASCTCLLGPNALFIGSEFTDSVVLGWDRKSNQTTRQKHFLEFSEGSDDISLEDDDDDVDDDLYGDGQSVIASINNGDVSDLENNKAGDYIFYIDDTMINIGPISDITFAKSSSQIAKIPSNNMEHICGQLDMVISIGKERAGSLAIIHENIHPEVIKEIHFPETRGIWTINVKKPTDKSNEISRNKDNLKTDFRLQEEYDRLMIISKEPEEGSKVSDVYALGSANFEALTGTEFEPEAGATIEASTLGNGLRIIQVLKSEVRSYDGDLGLAQIIPMYDDDTGAEPKILSASFADPFLLLVRDDFSIYVAQCDENNELEEIEKLEKSLQTTKWVAGCLYNDHTGVFSLEKSDENSASRQNVMLFLLSAAGGLHIYALTDLSNAVYIAEGLCFIPPILSADFVARRAATRESLVEILVADLGDEVFKSPYLILRSLYDDLTIYEPFRIKHSSSLINLSTNLRFLKISNPHLAKNTVELSEIVSSPMKSITNIGGYSTVFLPGASPSMILKNSKSIPKVISLQSSGVQGMSSFHTAGCERGFIYADIEGIVRIAQLPSNTSFVELGKSLQKIELGEEVHAVTYYPPMECYVVATSSKVEFEIPKDDDHHREWAREDISFKPTVEQSFIKLINPINWSIIQTIELEPCESILCVKTLSLEISEITNERKQLITVGTAVCKGEDLPTKGRIYVYDIVTAVPEPGRPETNKRLKQVAKEDIGRGAVTAVSEIGTQGFMLVSQGQKCMVRGLKEDGSLLPVAFMDMNCYVTCIKELRGTGLCVFSDVIKGVWFAGYTEEPYKMMLFGKSAKNFEVIAAELLPDGKELYIVVADVNCNLHILEYDPEHPKSIQGHLLLHRATFSLGGHFPTKLTLLPRTKAPALNLSNLHTASNSTETTNAQDYHVITTSSTGCISVLLPLSEFQYRRLSTLTTHLANTLSHPLGLNPKMYRIDRDAPDSMAGSRTVVDGTLLSRWMELGSQKRAEVAGRVGIDVDQIRDDLVDLQCGLRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P5</accession>
    <name>A0A0B1P5P5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002233">
        <property type="protein sequence ID" value="KHJ32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5P5"/>
    <dbReference type="HOGENOM" id="CLU_059789_0_0_1"/>
    <dbReference type="OMA" id="DECEHAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="389" mass="44766" checksum="466F0D5F33FCDDC4" modified="2015-03-04" version="1">MDKENNWGIPILSGDNHDSWFRRYKVKLTGKGVFYVVEQTVSEACRIASVDSLTKGVENLDLKQEQNSSTSRTEGIMNLEKREKYLRDEATAIDYLFKSLSLDDQALYDEHDTAYDLWLYLKKKYQQTDPTTANEYMTLIQTFTIGDMSIINAWDKLKDFRRKLCAADPEAKDTYRDRALLLILIRALPKDFTSTIDTLDAQPDLSVEEKLKRLQTKESRLVNESKQDQAFVGFTRNSESKPYMNRTRLQASEGDESGYTPECYICDRRHFVKACPFMEVARLAVQDYIRQEKLMKKHNLKPLPNSKNPSRPSSLPKHRKRTDLKKSRAYEALSQSNSDTEASLTSDESDECEHAQISRALISKVTPSTWVAKTNPSKDHNGGRWKAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R3</accession>
    <name>A0A0B1P5R3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001091">
        <property type="protein sequence ID" value="KHJ34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5R3"/>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="979" mass="109670" checksum="986B646772329907" modified="2015-03-04" version="1">MINHVFSPMSGVSQLKRRRMSTESPSLSQRLCSSRASISEASGVYPPKRPTPSLQKRVSLKLPSSRSPGASTIVSHDIEVEKIKWPTPEMESHEEYDEINEVFMAIDMRSRETIGCAYYKSLEQKLYLVEDVKMTSLDIIDTLKLQIQPTVVLISCKAEEKLEYHLSQDARGIDREGEGNDVLGSYILEHRPSSDFSFELAKLKLVNLVLDENENDIVITTPDDIIGNPAEDQNFRHSMGRQGRLMRLSGKIDLESKVTVGCAGAVLNYISRRRKSEYLPHYQDNLIFFQVRGIKMVSLSDTLFVNADTFTSLQIILRENHPNSYMQGPSNSSSGAKESLSVYGLFCHLARTPQGKQKLRQVFLRPTTNLHIINERLKAIRIFLRPENSHYLGKVHDNLKMIRDIRTVVLHLQKGISDISGKGNVFRRGVWGSLQNFTFNVLQILDAVDEISDTDALSITVKMATEINPAILNQVGSLITDTVDFHASAELHRTAVLQGVDTELDSMKRTYDGMDNLLTQVANQLSIHVPEWAAQYIENCIFFPQLGFLTVVSLDPDTGNGKYEGEGISNDIWERMFVSNDMGYYKNHCMREMDEYFGDMYGKICDREIEIVHELAVAVLKYENLLVTASDLCGELDCLVALALGARKYQFCEPQITLENVISIEGGRHPLQELTVSAYISNDCSIFGGSGDTKESKNTIESQKHATQESIEGPSMLIMTGPNYSGKSAYLKQNALIVYLAHIGSFVPAENATIGLTDKIMTRINSRESVSRNQSAFMIDLQQVALALTLSTHRSLIIIDEFGKGTNPTDGAGLCCGVFEYLLSLGSERPKVLAATHFHEIFENGYLCERPELAFGHMEVRVDNESESSEDQITYLYRFLLGRSISSFGTCCALINGIDPVIVKRAEELILFAARGEDLTAICARVSADEIQELEVAEKIGRRFLEQNFPDPDQQQKSDSQLLEEIKGLLKNILHSNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S0</accession>
    <name>A0A0B1P5S0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dnaj-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002398">
        <property type="protein sequence ID" value="KHJ32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5S0"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_1"/>
    <dbReference type="OMA" id="MPIRKEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="40025" checksum="59B5C38DFAC5267E" modified="2015-03-04" version="1">MVAEKKLYDALEIDPSASQDEVKKAYRKMALKHHPDKNKDNPSSAEKFKVISQAYEILSDPEKRSLYDKYGLDFILRGGAPPPDSAADGSQFFTSGTGPSGFPFSNMQGNDGTFRYQFSSNGRGPFKFSTPESIFSSFFADQSSGFSEFMNAEGPRRSSARSQTSTVFGADSPNIQRASTPEVAAVTRPLPLTLEELYKGTHKKMKVKRKVYDQVTGKRMTEDKVLEMDIKPGLKKGSRIKFKGVGDAVEGGQQDMHFVIEEKEHPRFVRDGDDVLHTVELDLKEALTGWSRIVTTIDGKQIKIEKTGPTQPGSKDEYPGQGMPLSKKPDSRGKFIVTYQVKFPTSLTLEQKRKLKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X1</accession>
    <name>A0A0B1P5X1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001860">
        <property type="protein sequence ID" value="KHJ32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5X1"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="33052" checksum="5F008E319D042E0F" modified="2015-03-04" version="1">MSKYGCLVMGPAGSGKTTFCSALMTHLRNNRRSCFYVNLDPAAENFAHEPDLDIKDLITLEDVMEELSLGPNGGLIYCFEFLLENLDFITEALDPLTEEYLIIFDMPGQIELYTHIPILPTLVKHLTRTGALDINLCAAYLLEATFVVDRAKFFAGTLSAMSAMIMLEVPHLNIMSKMDLVKGQIEKRELKRFLDPDVALFDDDYQETEEEVDDSRPPKDVDMVMGGQSFKMLNKSVARLIDSFGIVSYLKLNIEDEESVGSILSFIDDAIQFHEAQEPREPHDEAEIDYDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P697</accession>
    <name>A0A0B1P697_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="JNVN01000990">
        <property type="protein sequence ID" value="KHJ34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P697"/>
    <dbReference type="STRING" id="52586.A0A0B1P697"/>
    <dbReference type="HOGENOM" id="CLU_004962_3_2_1"/>
    <dbReference type="OMA" id="AEIMAIC"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="334"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="544" mass="60429" checksum="1D721D02D7B3D6D0" modified="2015-03-04" version="1">MGNQPSKGSAGSTLKSRISPMTSADNLQTYPSFSKADTKESNLSFKALRSKIPGSRNDSPRSSSVSVSSSNSPPEKIDATSLRSGRSLPSIRSRSRASLPDPSAIATAIQANSESNLPSIIIPDESISPIEDELPPPTPVRPRAMQNDSSNMDISRRVGEIGNVSEKPLSGNINPLVSLEQAGESILVKRPSLGAARYSMDNTSSHSKYHISMSDISEADVDEYIKRLLDTGYDGKHTKTVCLKNAEIVTICARARELFLEQPPLIELDAPVKIVGDIHGQYTDLIRMFEMCGFPPNANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRTNVKIWKNFIDTFNCLPIAAIVAGKIFCVHGGLSPALVHMDDIRNIIRPTDVPDFGLLNDLLWSDPAKQTREWENSERGVSYSFGKKVITDFLFKHDFDLVCRAHMVVEDGYEFFEDRILVTVFSAPNYCGEFDNYGAVMSVSPELLCSFELIKPLDSNALKSQMKKARIRRNSLMNSPPNITIAQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F8</accession>
    <name>A0A0B1P6F8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001209">
        <property type="protein sequence ID" value="KHJ33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P6F8"/>
    <dbReference type="HOGENOM" id="CLU_003025_0_0_1"/>
    <dbReference type="OMA" id="MPEIGYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105">
        <property type="entry name" value="DIM2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105:SF1">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1586"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1770" mass="199232" checksum="071581E0EB681DD6" modified="2015-03-04" version="1">MGADKKISLLPAPTESDSTNGGTEFESRITDRTSFSLPEDGSPITIATRRRRPGKDGLGLNSNKSQTSLLIEYFEGSKSGQKESRRPSVRVKVRPSSKIKSRLSSDRIQISERRSTRKTSYTKQSQFLSNPKSTILPEFETDNLSTRSHRSITDESNLSSKGSGSIEVEITPRRHGSPLIPVLDAKLRTVQINPSEISSVPDDSFLDGKVQSTNYKRSLTNEKNINTFLTSGPKTEGIKDQLEMPLRSRSRSLSRERIVVQKAVEKVRNENSEQRRRKHSSRSQSISSDIVNEPIRPLKKLIAPHKDILASGADSSLINSHLSTKSGEAYSLRSGTSRSSMNNPKLLETVEDAIRRLILPELTALKREQSRHLHHNHNHRNSMTSSSGISKESNEGDLNGKNHEQVTGSENAARPEVRFNKADALSKASAKWLPDDKHVGYVEDSSATIFERETIIETVIRESGRLQSNRSKENPYSQNVTEVGDEVLEPIVGLLPKNSHESFDREEKKGLRRRNRSRSRSHSRSNSLSNTYHETGEGNSQMPLLHEINPSEITRSSILSAPSETLNQTYKEPLTPLREVSRGVVSPISRTLSRTPVSLQHNLGTQHSNFSRDNVSLHGQHSEPHLRSTVEYELDEYGQKIMKENLHFYGSVEENYQNKDITKFKSLQTSGHKDITGETPMTVEIRNQVPQPIQEKGDYFYQEIQEVPSPLRYTSYAYERRGLSPIQSVSGYTDGEPENKRDSRLTRSSGSYSSIGRHAMQRQSVISTKSLDSIGSQHNPYDFPEVRQGGLADSEITQDLEYWEEQRRENDRNRRMDSEFHKTSRNQMVYEYQANYSGKNVKERDSDLSGFNDNQKNAHLAANSEPAIALAVNKAELIEVETHSNIANKGLFTPSNQSEKSFDSSERKNREIPKNENFTDTNLVTGQVLETQHFTNETGESNISECQVSFTTEEAMKSAATAALENRKTNLAVDQGRYNDDSHEISRSIEQKSFKERAMKISGQQHLQSLEKDDNKLTQHEVVQMGASGIPDLNDPMPEIGFGHRDSEDLTNPSIIGSFKDEPQHLSRDLASVRSRSSQRPQSSNSTQNLIFKTTERVEEHVQETSRLSIGGHREDKDHEADNGEEWGRDSLDRKRETIVTNPYENTSPVAAADVIDRHLPEFKSFAPSKLSLPERGVSYPRNEGYTSPIHNQSPGALTPEQETGNQNCDPFYTPNHQRNFSGMSHGMSSPLYDSATGNGIDRIESRDIVALMDHLTVRDAQRSARDTEILVTLVRAAAEMRNSFEDMKRLLADTEDVIITEVQANTEKSVQKVMYGPRPPPQSGRKSFRPCSYHEMYEDIPAKKRNVFRRALKGLSMKSANDLGKIEEMLVQLLGEVEGLKVAQGLKPVNQRTESQDHFNRESQIYAGNGPESNGSLSTMENSSPPGHAFRETTRGVCTSRTFDTRKNSDHRFSTVMEGNEDDTETKAIDHKAYRTEKNNQPSTPLNEESQRGQANSSTPVGPNIHCDQQNLPIAAEKSKKHKSGSSSSWIPKVSRWSETTASTVFRGFRSSVRSSIRKADDASPPSRSGSESGHRLENPPCSADKMDNSHDRSQNHENIETSIPNNSSEDPKFKAHRDSKNLQHPQPRLGSTDHHQTTLETQVDIFESQTPPNNNEWDREKNKNQSDIQQRNRYSCSMSPTPDEEYSSNQPSRKLSQEHLGYDRSMKSRVKPAKPSPLSNENLTEEPCDHPRSPPNHVRTQHSISTRRPTGPRTMCYPQSDCCDQQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K8</accession>
    <name>A0A0B1P6K8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative endosome-associated ubiquitin isopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000957">
        <property type="protein sequence ID" value="KHJ34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K8"/>
    <dbReference type="MEROPS" id="M67.A06"/>
    <dbReference type="HOGENOM" id="CLU_023304_4_0_1"/>
    <dbReference type="OMA" id="SWGVFRL"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="343"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="519" mass="59321" checksum="EAA1D0F8CD6BCEA6" modified="2015-03-04" version="1">MTEPSPHTFRPMSSKELAIKAQDFDFNPLIPLKFWVRTSDTLLREALIYQQEGNDQQAYLLFMRYAALTAERFPLHPSFKDPEYKLSLNSIKKNLPSVLDSMEVLKPRINSRYNAWHQAESLAETVAQKHNRERKKIANDIILPSDPAITGNMSSMLAAADNSELAVKIAQEEIDRRNKIRKVKLQASLLQKNDFQENRSEFLSNLGPEEKDDIYEDVPQSCIEESGKLLANFDKTSFYYSDDYPLEQRQNKRLIKSNYQYPTVMKPQPLTSEFNQHRNLKIPLSFPPNPPPKYSFQHKTSDEDAPPPRPQKLLNSLGSLESNVPSYTFRPSSYLENGKPLRTIFLPVSLRTEFLKYAESNTRKNLETCGMLCGTLISNALFIRRVVIPEQESTCDTCETTNEGALFDYCDKQDLLVLGWIHTHPTQTCFMSSRDLHTHCGYQIMMPESIAIVCAPSKIPSWGVFRLTDPPGLSSILNCTHTGLFHPHHETNLYTSALRPGHVVETEGMEIKVVDLRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6R4</accession>
    <name>A0A0B1P6R4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nuclear envelope protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000911">
        <property type="protein sequence ID" value="KHJ34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6R4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6R4"/>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="9" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="965" mass="108753" checksum="04443697F7434E83" modified="2015-03-04" version="1">MAPDFQTIVQLLQATLDQKQYKQAEAALKIEECKPGYSLLLLNILASENVPFSCRLSAALCFKNFIKFNWADEAGQYKLPSNEVETIKKELIGLMITVPVSLQTQLGETISLIADSDFWTKWDTLVDDLVSRLTPDNPKINAGVLEVAHSIFKRWRPLFASDALYTEINHVLEKFGKPYLQLLIATDQQIITNKDNGDILKSYMKVMNLLVKLFYDLSCQDLPPIFEENISDITVLLHKYLTYENPHLDTKDESEAGPLEMVKAGICEVITLYLQKYEDAFGSLCEPLITNTWTLLTTVGSETKYDILVSKALHFLTAVSNLDKHAQNFNNNEILGQVVEKVILPNVSLRDSDIEQFEDEPIEYIRRDFEGLDADTRRRAATDFLQKLLQKFPELVTAVVGRYITHYLELFNKSSGAEWKSKDTAVYLFCSIATTSVNTASHGAKTVNSLIDVVDFFQKNIANDLIASSGVEPILKVDAIKFLHTFRSQLTKAQWTAAFPPLVKNLASSSNVVYTYASITVERVLSLTTSSGQNIFEKEEIKPFAKDILEHLFQLIEKGNLPEKIQENEFLMRCVMRVLIAVKDGMIPIIDNILLHLVNITEVIGRNPSNPKFYYYHFEAIGTVVRYAGQVHQRKLEDSIYASFLRILQNNIQEFMPYVFQLFAAMLEISTNDSLPEFSKNLINPIIAPALWESKGNVPALCRLLGAILHRNAPEIIKNNQLEPILGIFQTLISKARTEIYALDILEAIITSCDVNSLEKYFPTILTLIFTRLSAQSPPEKFKQRFVRLYHLVSSRDELGMGADFFIKHAESLQTGVFAGVYLSIILPTTQQLARPLDRKLAVISLTKTLTDSQCFAVKYAKAGWGKTCDALLRLLENPPIISMDNEAAINVDIDVNDLSFGVGFTPLHSCKKIAKDEWPDVTDVKSWVSLYLKKADSRHSGAIGRFANERLSPEAKSLLASYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6X4</accession>
    <name>A0A0B1P6X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative prefoldin subunit domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001624">
        <property type="protein sequence ID" value="KHJ33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6X4"/>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17551" checksum="A615E9C60FD5CDC2" modified="2015-03-04" version="1">MSLSNDTQTSIELENLSLQQLSQVKKQLDDELDHLTNSFSQLRGAQTKFQECARSIENGVSPAIMEKPILVALTSSLYVPGVLADPSHVIVDIGTGFYVEKTTDDAKKFYEARVKDLGSNLKTLESILQGKVNNSRVVEEVLRQKILKVGSTEVSPKATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P773</accession>
    <name>A0A0B1P773_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001836">
        <property type="protein sequence ID" value="KHJ32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P773"/>
    <dbReference type="HOGENOM" id="CLU_1373120_0_0_1"/>
    <dbReference type="OrthoDB" id="5429132at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="22313" checksum="C0B004145F84539D" modified="2015-03-04" version="1">MASKRPNKRISIRAKTNTLSTMSQTNSSHNKSCNSLAAKIKKRDKRLKKRSVFLSNIEIPHKIDPKKCRRPSKKLVTSLSNLLDALPNDTQLSEGLTNENNKNKPRSNSLKIKLGVSKKRAKIEKEEKTRFDMNLVKILEVGQLKNFTDDQQLNISIDNTVKESSELGGLQLSSIATSSKFAAIRAWASANLDIHPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P775</accession>
    <name>A0A0B1P775_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001046">
        <property type="protein sequence ID" value="KHJ34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P775"/>
    <dbReference type="STRING" id="52586.A0A0B1P775"/>
    <dbReference type="HOGENOM" id="CLU_006198_0_0_1"/>
    <dbReference type="OMA" id="YRRSEAK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000072">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120605" checksum="34055BD2572313CD" modified="2015-03-04" version="1">MRSNTQNAQSEKSILAQSVTVVFDRDKEEEQRKIFKQLYLATEPKIVQLFGNHGLKDYNFAQGKEEEADQQTTPENAAIEPVKECLPSKPIRNIDEDNYDDEDEDEETQCLPEKNQVTNVLQSQNKLELSFDSEIPSVKETISTAGNDQSKSSENVRKQLELAKKATEEAAKRSFHSLFFTLENDRVAMLEQQKLEESEKQIDAEINHAGTTSSNNTNGEHHGSLSSANLGASSLTLKHLIARIDLKRDQVRASDAELRSLMNEVRKNRSKWASEENVHQEELYEAAEKVLSELKAMTEYSAPFLTRVNKRDAPDYYNIIKHPMDLGTMTKKLKTLTYKSKAEFVTDLDLIWSNCLKYNADIHHPLRRNANSMRKEAEKLVPLIPDLVIRPRAEVEAEERRKQNGGDDDVGDESDDEPVMSSRGRKAGAKGSKTRKASNRDNESPEIDQKPARQLNGTLGNHNHDVSDVRIDSNQNGFATPPVMSTTPLGGVLGHDSQSDAMDIDKSLINGLSLTPNEDVEEDEEYKIWKQVTKKDRALLAKERNSLFKGDKLNPDEPALLRSKIGMRRWLRQKNQLQSQLSPLLGTISENENTAQGVATLAEGMEGGEDRALPDYYDYLSAIPDIPTRLQWHEDSEGQLADRSEDSMRMVPKGLFTAPRSLLTSKFEANLRQMQETRKLCSKIGVIKQMQLQAQSYNNQFPKYEPQPFIEMDIEPHVVSDDGPIMAAGVCKKALQRSVAKVCYAAGFEELQPSAIDVITDIASDYFGKLAQTFGLYREAPKIPLVGTVAVSSSRFQERFTDEEVVLHTLSENGLDIEALESYVKDDIERLGVKLGVMHERMRAHLSDLLRPALVDGGADGSGAFKDGSEQFVGGDFAEELGEDFFGFKALGLDSEFGLSSLSVPLHLLHTRLYNNQPSQVAQGPMADIFQSLPPLKPITKDNIYDQIGLIQNFFISRLRGNSDAPLIEDDELPIKQRPSRPRLGPTGKITTPRKRPLKDAVGNLRKKKKLENGVAADPVISNKITESSENICVSNLKKTKSALPNGIEKVESSQDTQSQMEKENISVGGMMSPESIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P798</accession>
    <name>A0A0B1P798_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001030">
        <property type="protein sequence ID" value="KHJ34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P798"/>
    <dbReference type="HOGENOM" id="CLU_998177_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="31767" checksum="BDE11AD032D7645F" modified="2015-03-04" version="1">MTQDPSSKLKKQSQEDFEAVSNQISLILAQRHSLIKSWTASISDSAPPEKTSEELDAEDAALLHSQPFYLGLGAPIPAQFQLSEIERNNRLLRARLSGSKSLKSKQTRDGDEKSRYLKKLHKEIDNSSDEELGRSSVGKAKKMKYNKTLEDSDSMLLKKKKNLKIDEISCNELNKENKSLIQSFSDNLSIKTKSELENMNKFSPSGVSGDNNLENNIQENNIQLDEQKATINLEPNLDIPNSETKKKMRKKEKRKRQKLRIKVENKSKKLSTENQTTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7D1</accession>
    <name>A0A0B1P7D1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7D1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7D1"/>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="5">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="26174" checksum="04C5ECC983D6A3C2" modified="2015-03-04" version="1">MENLHAVTIPSDPTSAGKYKTGVITEDLTFSQLQAKKDNLESEIRALGGVLDSHNVDMKTPLLTLDGYPRADLDVALIRTTRARINYLVNDLKDLMNIIEKRIHDHFAQIAKDGISEEPSLIREKPEPCLASKQIPYPQESLPPFAKVNSVVENSPAASAGLQIGDLIKSFSYVNITNHDGLKRLSECVQGNKDKDIILTVLRPLDSLRRKELTLTLRPTQNWGGKGLIGCHILPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7I7</accession>
    <name>A0A0B1P7I7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000760">
        <property type="protein sequence ID" value="KHJ34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7I7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7I7"/>
    <dbReference type="HOGENOM" id="CLU_002055_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74814" checksum="7A85B25BE87B4F8A" modified="2015-03-04" version="1">MNKICHHCQIYGKSPGRLRFHLRDDIEFNAVIIADIFYITENGKAQPVLHILDEATRFQNGEFLEKETSQEVWEKLRMCWIDAYVGPPDTIVTDAGKNFTSKELQYSAGRIEDLPHLSKRACLKMAFKAINDTAGPKGLVPTLLVLGAYSKISNLDAPAVSVEQRAKEYEKAMEDVRKLRAERQVKDALSMRNGPITSTIRDPPLQTQVLVWREGGIGKKGSWQGPYNLLGIDGNTCIIQMQQNNNKPSLFRITSAKPYYQSAQIETSDEDRALHESKDPIQSTSQEEKIYQTTRTQQKRSAGRPNRYAIYCQNEPVYETFISNDLPRDGFKTSRKIECRGLVDRMVTSFVNKDQIPPGTHVYNAKFIDSIKNKESEEWFEKSRLCIAAWGDEDKWTVLTQSTTIQRASQRSILAIAPMMMAKGCFIYDRDVEQAFTQPKTPINRPFYFRAPVELCQEMGISVGSIVMLNLPLYRAPESGNHWFNTYHKHHTKNLGLSKSAYDPCLFIRNDDEYFGVIGMQIDDTFGLTNTKFAELEEEKIKVANIKSVQVINPNMDDAKALNKALQWQIENPKRGLTFIKIEEDFEVSVFVDSSFANNKDYTSQLGTIIAIKDKTRHINIIHFNSIKAKRVVRSVLNAELQGLLLGFDMGVCIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7J3</accession>
    <name>A0A0B1P7J3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001917">
        <property type="protein sequence ID" value="KHJ32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7J3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7J3"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="OMA" id="KGASWEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="35841" checksum="0E18A0D2DCD8D21C" modified="2015-03-04" version="1">MLPTEIKRFTDLFLDDDSHHNKSLPPHRPGIDTNIVLEQDDQGKDKQVPWGPLYGMSREGLLVLRKTLSELLDKSWIRVSSSPGGAPVLFIKKPQGGLRFCVDYRALNAITKKDRYPLPLIKETLRMVANASYISKIDVRAAFHRLRVAKGDEWKTAFRTRFGSYEWLVTSFGLAGAPAAFQRWINQVLGNLLGDICAAYLDDVIIFSEGDLDDHWNKVRQVLDRLRAAGLRLDPQKCDFAKKEMKYLGFIINVKEGIKVDPTKIKAIRSWEAPKDIKGVRSFLGFANFYRGFIRHFAKISDPLIKLTKKGTSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7P2</accession>
    <name>A0A0B1P7P2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nonsense-mediated mrna decay protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001492">
        <property type="protein sequence ID" value="KHJ33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7P2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7P2"/>
    <dbReference type="HOGENOM" id="CLU_018549_1_0_1"/>
    <dbReference type="OMA" id="QYKPGKV"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="421"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="58226" checksum="B7D0FC887A5D30D8" modified="2015-03-04" version="1">MAPPTARLKIIIRRLPPGLTREEFTSTLGPEWDVGQGRVDWAAFKPGKISKDPSKPSRPTRAYLHLTDESYTITLAEIVRNSTFEDAKNTFYNQSLIGPPTIEYAPFGYIPSDRIRVDTRAGTIDQDSEFMAFLEGLVHPIKEQGPEISTDVNSKQEKITVTPLVQYLIDKKANKSKEAALKSLKKQEAHSSKGKNVKDANLGPDEIKNRRETKAEKLSNKASKEAVKILNRDIASKTHQASIRPTVSPTTEVTSPQSEVEKLTPARQRGVAMAAHIRMLHRDLGITPAKANRLVRHETADALKVEKSAINEKNPSVKNTESSPTQNLVIPTAPRGKLNSRNNRKNRGKGHSNKPDCSISTSATSRPQTPVVLLKKVETHKNIISSNNSDPISPLTPPTKPRRAGPSKKSQLIIPSVEGIVQAFVKHANPSQGITEHLLRQAMERFGEVTMVDFDRRKGFAYVNFLDSEGFKKAMAASPIPIANGAIQVMPRKAPVSQQEKKKTQQPPHGPSRGGRGGRSGNMGGRAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E7</accession>
    <name>A0A0B1P8E7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8E7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8E7"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_0_1"/>
    <dbReference type="OMA" id="VGACTIV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="31"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="44085" checksum="2FE45C0BBAD47EF4" modified="2015-03-04" version="1">MNFLLLELTTFAWQQAILGITEAFKADCFAEKINLGVGAYRDDKGKPYILPSVKLAESRIISSNLNKEYAGITGVGEFTKAAAILAYGSNSTALDRVAITQSISGTGALRIGGAFLERFYPGAKKIYIPTPSWANHAAVFKDSGLVVEKYRYYNKDTIGLDFEGLIEDIKNAPKGSIFLLHTCAHNPTGVDPTSEQWKEISSAISASNHFSFFDMAYQGFASGDTDKDAFPVRHFVSEGHNICLAQSFAKNMGLYGERVGAFSIVCADSEEKKRVESQIKILVRPLYSNPPIHGARIAAEILGNKELNSQWLRELKAMADRIITMRKLLKDELEALGSKYDWSHITNQIGMFAYTGLTPDQMERLAKEYSVYATKDGRISVAGITTGNVKRLAAAIHAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8G2</accession>
    <name>A0A0B1P8G2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative iq calmodulin-binding motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000592">
        <property type="protein sequence ID" value="KHJ34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8G2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8G2"/>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="OMA" id="FHAWKTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="983" mass="113230" checksum="9C669F8201AB6079" modified="2015-03-04" version="1">MQSSSASINGSDHNFIRTEAPVDTEKQGLSPTLESSDNRIHIPPPRIAARFYRPTVNNQTPSSSYYYNSVSYVQLHQPNNIHRESKNSFAAQHQRRNSLIEKKKAKFAVRAAHAEEVRLRAAYFKAAPRSATNSEEKAIAAKLAREKILADIAAACAEEVKKAKEIAESVKEKREAEVHKLRKIIEERLAEAEKRREKELRKCSGVKRRHAHSYCCKSLYRNLKSQSAISINVAASRIQKQWRIYQRIKTIKEFKAVGITIESVKQEPFDLMARLVGQVDVLMVTVRMLRICGLKELEVQSTNEMANVRIFLSAYLILGYPKQTLGTGDGREDLAEVFDKDNSIDTQFHDIVIKARDLITSFEKIILHLSPVNNYMASQSQQSNLLENYAYFYKAFIAWKARDSDALINLMFLQFIELEKIWLSVKDNTEEVVTESYKKGIRDNQIMLMTRIKRLAGEKRYKQIMSRAMREARASRSDKQPAKDIQMCKKFSIEANESFANSTLPSGNEMIAILNPISAPIKNEDNITSSVDIIKFAQPIMQQNRIITHEIAINKEFRISEDIIPKRRSAMRTAFDLMRNDIKAGNHDEWVLATAYNVRKKLQRLLTEGKSMHASIGEWLDHDLIATQLRHQSFSYDKFFHEISQLLPKLCAPFRDKEIRKVTEEDFRDSDVVSRIEALMYALDILQLDYANFLLQQQIPLILANAAKYETHQFMQQLAETNNSLQITENAWKTAHDKVMVDFSRRETEKNNLHFNKSTSEKTYVQMLVDVFTNTDEEAMIPETLILDKNRIIRIRSEVLRIVTCGAILLQCKNVLKRDVRSSWKVEGARIFIVLENVKSQEQAVQGIQTALESSRSMPSATKDYIHELVYRTIKASNLRKPHLADPVLRLLMNRLRGYFLTRLGTRTEREKNRNSYNNSESLVTLGLPEYSQKICDITNEIGRVAIVDREAHGKWYEQIIKKFNVDQTKDSNEMEIDVSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H3</accession>
    <name>A0A0B1P8H3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001557">
        <property type="protein sequence ID" value="KHJ33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H3"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="181" mass="20400" checksum="1CEF5E9A6FDBE63C" modified="2015-03-04" version="1">MVKRKLVQPRKGKPISPIKADIRIFLRLPHEHDWRNLSPAGIREVIVKKLAISPASIGRIKPVHTGFALSPCNDDAREKILEGQHGLFMTGAKLEPATNWVSVIVPTVPAYIRILQGKVEVSNTMLADEIERESLERPSYLKLYGQNNPAALHRTWMAFFPKAPRPGFRVFDESGLAMPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L6</accession>
    <name>A0A0B1P8L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative plasma membrane channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000798">
        <property type="protein sequence ID" value="KHJ34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L6"/>
    <dbReference type="HOGENOM" id="CLU_010867_0_0_1"/>
    <dbReference type="OMA" id="INSKPKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="160"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="714" mass="82354" checksum="7CFBB1049DD8C858" modified="2015-03-04" version="1">MQTLTSNPKTYDSSCSNFGVDLVIRYNITDPDKNHIEIQFARLIEALQTVGLTTEVRYGSSTYILIFVKDSLIDFIVTPALLSLRSSIQEGPITRAERLRLVYTLITSPISEGGVGVTPNSNEWKYVDDIFPLHDNTHNKQWIKKISSRYILDAENLAEIRDQFGEKTAFYFAFVQSYFLFLILPASFGFCAWLFLGPYSPIYAIFNGLWCIIFVENWKKKQKQLKVQWGMKDNHELEYQTRLLQGEITSHNSISGLNLKTILFLKQLLKQFLQIPYAVAAIITLGGLITICFGIEVFISEIYNGPFKKILVFLPTIILTVLLPAISAFLTKLASELTDFEDDKSRNSHETSMIRKIFVLNFIISYFPIFLTAFVYVPFGQIIFPYLNNFHQIIKTRSTLDHQIVPLKMIEFKVNKDRLISQVIYFTVTAQISNFGLEIIVPFVKRKVLSKIKEFQKRNARPDNRNLTINDHKSESKFLIQVRNEAEMKKYDVTSDFREMIIQFGYLSLFSVVWPLTAVSFLFNNWIEIRGDAIKMVTEYQRSIPWRADSIGPWLDALDFLAWLGSITSTAFVYLFSANGPDSSETYMNIKGFLVAIIIYEHLFLAIRLVVRKLLDNLDSSERQLEKVEWLKIREGHLKKGFKTEVFHKLSQQNDIKINISDCPLEDDSINNKSAFEGPVNHQFWKDNGTLAETVLNGKLFISRANFSDMKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8P8</accession>
    <name>A0A0B1P8P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000539">
        <property type="protein sequence ID" value="KHJ35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8P8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8P8"/>
    <dbReference type="HOGENOM" id="CLU_024465_0_0_1"/>
    <dbReference type="OMA" id="ELHMPMS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="55935" checksum="2C70858ADFC0E7EF" modified="2015-03-04" version="1">MSSQSLSPGGALLRRSKAFSIPKPIPRPVDTRITNQSVSKTSTSSFPSHLSITTPLSSLKEGDWGLKRPLPVRTTTKSSYPSVRIEAIDTVEKITSFRSSGDHAITLQKWQELDLPFTQNKQYPSDVRPSRISVFEDEVDNIEKRSDDNNKDNYRWKFKGPWFGGLSEGEFSVYMKTQVQARKREFQDYLRNECARAKTSETRNNYISESVDGEIPKFEASDITDKEYALFVKKLRSQRVQLYRLIRSFLDLPPAIFADVYDPTLTLHSLFGQNNNEKNNSQDTQKSSGTAPPKTHPSAGLYYGRTSNFMFNHPEFGPQVVKPPVKARVILPKNVFGSQSHTALIGISGFIMGIPPNIDSTFVFKKGFKDNGQFAYSKFPGLHSLDQSEETGCKSWIQCLHAELNAEGNVHVKWELGDPEAVAVRTDTVHELQPKPVPSSSTTVFWNKSVGNKKSTPTRISDARQYGLDSMLNSSAKTPPTSRETVNELVSLLNEGLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R9</accession>
    <name>A0A0B1P8R9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001522">
        <property type="protein sequence ID" value="KHJ33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R9"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="90" mass="9851" checksum="66FDC77A38B11873" modified="2015-03-04" version="1">MCMAATKCRNCGGPHRSDSRRCLARPTRSGTPTKEQLKTYRQAGEREFQAVARAKEAELKVANTEESRSNIIDSQNTDSTSSGSSTTNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U9</accession>
    <name>A0A0B1P8U9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g4392</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8U9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8U9"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="220"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="656" mass="72597" checksum="265CF43D4F45B7E6" modified="2015-03-04" version="1">MSDLNSWEDDPAAQDDSLPRQTQQMKLNNQQRTTAMTFRPEATSFQPAKNFEQYNVDTYQNYYGQQTTQNYNNFSQFRQQVTQTPVVTKRFTDSPTNLSDLNKPITTKENAPKILSIGGDSPKPKAKVLSIGLASSTEKKKANVNSTESSLIQESGTKATATKAIEKSLESGKISSTPPSGRSSPSRGATKPIGQDVDAVQKEIASADIDEETLKDIYGKEHVNIIFIGHVDAGKSTLGGAILIQSGMIDQRTLEKYKKEAKDMARESWWISWVLDLNKEERSQGKTIEVGRAFFETDKRRYSILDAPGHKTYVPSMIGGASQADVGILVISARKGEYETGFEKGGQTREHAMLAKTQGVNKLVVAINKMDDPTVEWSEKRYNECIAKLSQFLKSTGYNLKNDIHFLPIAAQQMLGLKDRVPEKICPWYKGPSLLEYLDSMAALERKVNAPFMMPINGKYRDMGTIVEGKIEAGAIKKGMSLIMMPNREKVEAAAIYGETEEEVTVGQCGDQIRLRLRGIEEEDILPGFVLCSPKRPVHCVSAFEAQIRVLDLKNILSAGFNCVLHVHSAIEEVTFAALIHTLQKGTGRKSKKAPTHAKKGDSIIAQIEVIGGAGTVCVERFEDYQQLGRFTLRDQGQTIAIGKITKLITNEQGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Z1</accession>
    <name>A0A0B1P8Z1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative gamma-butyrobetaine hydroxylase gamma-butyrobetaine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000492">
        <property type="protein sequence ID" value="KHJ35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Z1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Z1"/>
    <dbReference type="HOGENOM" id="CLU_021859_0_0_1"/>
    <dbReference type="OMA" id="MPYFEYK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="178"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="462" mass="52979" checksum="3F044965271656C4" modified="2015-03-04" version="1">MYGSTCFEIMFKMGILRTNLVSINSKLRWASTLKCVGVGATRKLHIPHFSFPLIQMQTRVPFLPRISTRCNTFRRLWDQNPIILRDACVCSMCVDPHSGQKNFKTSDIPVNIKAESMNLKEDGLHVKWINEIPGFQSHESVIPLDFIYAVPYTLSNTSQDAPRSWDCRTMQQLLPTLRFDYSQYINQSKTFHKVIKSIRKWGLVFLNGVPKSEEAVEKIASRIGPLRNTFYGKTWDVVSVNEAKNVAYTDKYLGLHQDLLYMENPPGIQFLHCLKNNCKGGESLFCDAFRVAEQLSSSDYDVLSKEKIGYHYEKAGESYQRSHPVLEIDPKDQSNAIGRPLPLFVNYSPPFQAPFALNFRSSTFTEFVQSLGRFAQGVESVENVFKYKLLPGECVIFNNRRVLHGRECFEAQANERWLKGCYLDSDVFLSCLRYIQMAEIHLRHENLNNLDSKDASSQSNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P919</accession>
    <name>A0A0B1P919_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000487">
        <property type="protein sequence ID" value="KHJ35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P919"/>
    <dbReference type="STRING" id="52586.A0A0B1P919"/>
    <dbReference type="HOGENOM" id="CLU_1778843_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="16760" checksum="ACE767B02EDA1407" modified="2015-03-04" version="1">MLQRNKPNGLVATAPKNQGAYNTDPAVHEGKEKLNESDDECAASDPYNSIYYQGMEEEEEDNQEEAKVNDDDNCVMEVGHVYAHNFQPVQEQHKKYHSELKAHETISKWNYQTMNGSKSPPEVKNTLQNIIKYNDKKCLICDTFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P969</accession>
    <name>A0A0B1P969_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative aromatic-l-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P969"/>
    <dbReference type="STRING" id="52586.A0A0B1P969"/>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="OMA" id="ERDPSHY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="420" mass="47144" checksum="9313E3CE7E51F462" modified="2015-03-04" version="1">MAFFPASSSYPGILGELYSAAFTTPAFNWSCSPAMTELETIVLDWLAKLINLPECFQSSSTGGGVIHGSASEAILTVMTAAREKYLDEVTSHLTGTQREEAMQYKKSRMIALGSNSTHCSTQKAAKILGLRYISIPVYPEDNYAMVGTNLEKVLSECKLLDLEPFFLTATLGTTATCSIDDFSSILSTLKRLNLLGQPGELWVHVDAAYAGAALVCPEFQHLTAAFEHFHSFNLNMHKWLLTNFDATCLFIRERKFIIECLSINRSYLENKASESGQVIDYRDWQIPMGRRFRSLKIWFVLRSYGVTGLQAYIRNHIRLGEIFASLCNERADLFKIIAGPSFGLTVFTVVSRISKDNELTKAVYQRVQQRGELHLTPCALGGVQMIRLICANRLAEERHIRRAFKILTEVAEELRDMEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B3</accession>
    <name>A0A0B1P9B3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001360">
        <property type="protein sequence ID" value="KHJ33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9B3"/>
    <dbReference type="HOGENOM" id="CLU_092474_1_0_1"/>
    <dbReference type="OMA" id="DVKVYRV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="154" mass="17571" checksum="5AD8D12706C6B04F" modified="2015-03-04" version="1">MHDEDYLNFLNKANEIDVQNSNGSKRLQLKSLDQSVEIPEALQQATLDAYYISDTDEPFVPVVLKVKDGMPDEISFAKLVNHPEPTNAEVQIMDTNKWDPHGQYKKIIDTVKEVVQNEEIRVYQIFLSNITSEYWLVGIKEESLLGVKAMAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C8</accession>
    <name>A0A0B1P9C8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="JNVN01000663">
        <property type="protein sequence ID" value="KHJ34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9C8"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_11_1"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="471" mass="52909" checksum="83AE6918BA4B156F" modified="2015-03-04" version="1">MGLGMKDIVEVWQPLDQQDDSQNAYLLKKVQREILESGICRPKGYTVSWHSNPEIEKHHFGHSHPMKPWRLTLSKGLIMAYGMHAAMDTYIARPAEKEELESFHTEDYLNYLKIAKVAQPDDVWPKDFNLGGYDCPVFDGLLNYCSMYAGASIDAARKLCSGQADIAINWSGGLHHAKKAEASGFCYVNDIVLAILQLLRYHPRILYIDIDVHHGDGVEEAFWSTDRVMTLSIHKYDGSSFFPGTGDLNPTGPDSEDNPGAHHAINVPLADGIDDEQYIYLFKAVVGKCVEKFRPTALVLQCGADSLAGDRLGRFNVQVQGHGACVAFCKSLNLPLLLLGGGGYTPRNVARAWAHETSIAIGCDNKLNPIIPLHTPYRWHFRHETLFPTLDQVLSEPRANRNSAKKIQDIISHITEQLRFVNASPSVQSQVIPPDLTGYKEEVEDRLREEQEEMDYERNTREEAFGSPMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9M5</accession>
    <name>A0A0B1P9M5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01000419">
        <property type="protein sequence ID" value="KHJ35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9M5"/>
    <dbReference type="HOGENOM" id="CLU_005138_1_1_1"/>
    <dbReference type="OMA" id="RDFSCEY"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000009">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="9">
        <location>
            <begin position="541"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="858" mass="97421" checksum="2E2DEE25B67AD249" modified="2015-03-04" version="1">MPGKRRKLNSEPLRANREISYFFAKQQDNLSGKGSSVTSDDNTKLNITVEQTDEELARKLQFQWNQQDAELKFTKQENNFGKASESPTLKSNYPLNFETSQLMKISKCVNETKENESSCTISLEAKTDKILCLQSSGLSGDSITSSIPFDENPLKFTPLKYWKEHEKKFFPDDGKASYALLTRCFVLINSTSSRIKIVDTLTNFLRLLIEGEPSSLLPSVWLATNSISPPFIPLELGLGGSFISKALKNIYNIDAKALKALYNKVGDAGDVAFEVKKRQTYTLRRPKPLTIKGVYQSLVKIANTRGNGSVEIKQRIVDRLLQDAQGPEESRFLVRTLCQHLRIGAVKTTMLIALSRAFQLSRSPGAEYPLKTIEELSSLSKEAITDIWSRGEETVKACYARRPNYDDLVPTLLEIGVCNEILIQCGLALHIPLCPMLGSITRDLSEMLSKFQDRQFTCEYKYDGQRAQIHCDDQGKISIFSRHLEIMTDKYPDLVALIAKIRGENVKNFIMEGEVVAVDHSTGEFKSFQTLSNRARKEVAIGSIKVEVCFFAFDLMYFNDEPLLQKSLRQRRKLLREQFTEIKNRFTWVKSLDATSHDSETILEFFNSAIQSKCEGIMVKMLDHSVDSFNYDDPDLLISSSKIPIVIEPSKTRTGVAQQEKRGRCKVLLSTYEPDKRLESWLKIKKDYTTCCDTLDLIPIAAWHGQGRKSKWWSPILLAVKNEITGSLEAVCKCISGFTDTFYKENKEFYREDGPNVLSRKPGFVEYDGGHPDVWFEPQEVFEMAFADLTLSPVYTAAIGLVSEERGLSMRFPRYVKKRTDKTIDEASTSEFLAELWRKQEARSLSTIDTKNSINDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N7</accession>
    <name>A0A0B1P9N7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001077">
        <property type="protein sequence ID" value="KHJ34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N7"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="274" mass="30497" checksum="B1125FB0A12F23FA" modified="2015-03-04" version="1">MEMSSHTSPIAPIPSLPHFPSPTATSHSPPSSTTPPTSVIENRKIVKPALPSKHAAQHAAVVDLTNDKSNKISSHAYLPQELANIVLAKQRQESAWHIRLSICTYILSNVESTFSIYKEDIEKEEADIIRKYLQKAIAYLFALDNAPQPPETPIESKPSKMKSVNLPRNSKIIDSHVANSKTPTLPSQNYSLNIKEQVACPKQTENSWVIVARNGHKKARTIATLATLSTGQSTKHNLLPSYPQHQKRNVNKKKTGKENKSDNRHFVRLPTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Y8</accession>
    <name>A0A0B1P9Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative short-chain dehydrogenase reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001412">
        <property type="protein sequence ID" value="KHJ33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Y8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Y8"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="NLANTMS"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="36863" checksum="63CDEDD870E5680D" modified="2015-03-04" version="1">MLYGLLFGGVSFSQEKDIPDQSEKVIFITGGTRGIGYQTALALARKNPAHIYISGRNQTTADKALASIKSAVPSAKVSYLPCDLADLESVKSCAREFLNREKRLDLLFLNAGIMVTPAGKSKQGYEIQFGTNHIGHFLLTKLLLPTLEKTTSLPGTDVRIISVSSIAHYFAPCQGIVFSELKTEMESWLSMRRYGQSKLANILFTKQLAKQLKNQDSKILAVSIHPGVVDTGLYEYIEKWPIFSVFLKIARKMMIFLMNAKEGANTQLWAATAPRATEKDVQSCCSRSNGKVVVGEFYTPIGAPGQAGKLTYDDGLAKKLWEWTEEEVKDYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Z7</accession>
    <name>A0A0B1P9Z7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2925</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01001410">
        <property type="protein sequence ID" value="KHJ33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Z7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Z7"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="245" mass="27382" checksum="198D612C3B280A38" modified="2015-03-04" version="1">MASFSKDKYSVILPTYNERRNLPVITWLLNKTFTEQYLNWELIIVDDGSPDGTQAVANQLIKAYAPHVILKPRPGKLGLGTAYVHGLKYATGNFVIIMDADFSHHPKFILRMISKQKTLSSNGGYDIVTGTRYAGDGGVYGWDLKRKIVSRGANLFADTFLRPGVTDLTGSFRLYKKSVLQKVIESTESKGYTFQMEMMVRAKAMGCTVAEVPITFVDRLYGESKLGGDEIVEYAKGVLSLWMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA41</accession>
    <name>A0A0B1PA41_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000347">
        <property type="protein sequence ID" value="KHJ35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA41"/>
    <dbReference type="STRING" id="52586.A0A0B1PA41"/>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="OMA" id="FRTQWDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="441" mass="50950" checksum="78E7CCAB8717DF56" modified="2015-03-04" version="1">MATCASYVSPFARYLKCNLISFNLVGGLKTFRRFSSLSQDVTIEKNMPIRTKLNPNTVTSRREERKLIRLGIFPIGSRRRRAAVKTSDNIPFEQLPYLCFQEARKILLEEREETLQKIKKQRLRISNLIAQDVSQIMGGQERKDSTLRSMKKYLEELKIQADLNDPIIKKCFEDGKGDMNKPVYRYLANEKWKSYHRKILVQRIEQFGIVPDLQPKFEPSAAVDLAFRRRRVQPGDYVNSRVSEVPARLKVQVFDKGERMISVIMIDADVPVVEIDNYIHRCHFLAVNIPISPTQTSLPLSKANPLTQLVIPWLPPFAQKGSGYHRYSIFVLQQPDGITFDVNSFKAKFSRDEFSLREFVHKYQLSPIGLGLFRSIWDEGTAGVMHRASISGADIVFKRKKVIALKPKSKPRGWEAKHAHPKYDAMLGKNRRPYSKILRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA77</accession>
    <name>A0A0B1PA77_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001352">
        <property type="protein sequence ID" value="KHJ33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA77"/>
    <dbReference type="STRING" id="52586.A0A0B1PA77"/>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22692" checksum="786493E02B44077D" modified="2015-03-04" version="1">MASSNIDNELLPEQTEGFKVGEKKTIDEYQKLDADDEAMQRYKRSLGLGGDGKDISDPNDPRQCIILSLTMDSQGREPVTIDLSEKGSETTLKDKPFKIKEGTKFSMTAKFKVQHEILSGLHYVQIVKRKGIRVSKDQEMIGSYAPNTDKNPFYTKRFAEEDAPSGMLARGHYTAVSTFIDDDKKTHLQFEWAFDIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAA8</accession>
    <name>A0A0B1PAA8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001173">
        <property type="protein sequence ID" value="KHJ33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAA8"/>
    <dbReference type="STRING" id="52586.A0A0B1PAA8"/>
    <dbReference type="HOGENOM" id="CLU_018821_0_0_1"/>
    <dbReference type="OMA" id="FRISCKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="595" mass="66628" checksum="859EE1945BC0E10F" modified="2015-03-04" version="1">MNVSQNYNDKFQFQFTGNENSSIVHELSTSFTFRNSEDLHNILLSAAQIEHNKVRESAINLFELERVRYDQEAFRNKIREDEERVRLEKEKAIEAKKNQESLEIVKRPPTPPPSAPALPLDKNNASTLLSPNASATQQLPLPTRPMNSFPDRLTTQSLPTGTFSIPKNFESSSIDMLNSSPFSTKTTSSFSHQPITALPKVDTKSGISQTALSNTPFSTVRQQSNEPFSSQPIKSSDRAPLGPTQEHNPTVAASDPSTIHDQHFVKQSLRFEKLDRYYEIHRNMKNLRKSIESQVDEFGKPTSFRISCKKGRREITKVLGQLIVDSRNTAIVDKVIRQLIDSLQDKSEIVDASLFTLKNRRAISTAYLNEDGADMNSDKLPSAFIYLIGAFCKAICAQLVNEAALKPQAASPIGILAARIFSDPRFHWRGDSLIDILISKMFKICPILFGVCGDESTHEGRVRIGWRKMNGKFISDQAHFDRMSGVAAGYAAISLRDFSRTRWKNPYPPTNYWLTLSAIVNTPSKEVCSTQYVVLKSLIEHSFSRFIKFYGDMAIAALQAALVEFPMRGAENSASVGTLRTLCVSLQKDHGLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAB3</accession>
    <name>A0A0B1PAB3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001172">
        <property type="protein sequence ID" value="KHJ33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAB3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAB3"/>
    <dbReference type="HOGENOM" id="CLU_057784_0_0_1"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045015">
        <property type="term" value="F:HDEL sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="24810" checksum="FB9AF973FA5BB42F" modified="2015-03-04" version="1">MNIFRILGDFSHLLSILILIRKMHATNSCSGISFKSQALYLIVYATRYLDLFWTLGDNLYNTLFKLLFLGSSSYTIYIMTNAYKPTHDPNVDTFRIQYLLGGAFVLAIIWPYKYTPLEILWAFSIWLESVAILPQLFLLQRTGEAETITIHYLAALGAYRALYIPNWVVRYLTENHCDWISIIAGLLQTLLYSDFFWIYYTKVIKGRRFALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAD0</accession>
    <name>A0A0B1PAD0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6307</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAD0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAD0"/>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="49"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="710"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="954" mass="107948" checksum="855EA6D687D9A1E1" modified="2015-03-04" version="1">MRITKESMQAGKFYFSQKSWSFSLKLPKTSFPARPSVTDQAVYLRRCTDDLYEWQTKERDGHSTFLLNDGPPYANGDLHIGHALNKILKDIICRRRVQQGKKVIYVPGWDCHGLPIEIKALERQRISDTSDGVYDSIKIRKAARELASETVKSQMKNFREWGIMADWAKSWKTMDKSYEIKQLRIFQSLVRKGLIFRRFKPVYWSPSSRTALAEAELEYKTDHCSTAAYVKFPISKMPDILKNNLQFSGKLFAITWTTTPWTLPANRAIAVYSELEYSIVNYNSEFLIIAKNRVEEVMKLFTEKPLEIIIDSILGRDLKGALYTHIFGGSTQFPIIEAEFVTSDSGSGLVHVAPGHGQDDYEVCTRLGIQASAPVNDSGCFTADAFPENSSSLEGKSVLHDGAAQVLELLKQNVLITHKYKHKYPYDWRTKLPVIIRATEQWFADVGSIKNDAIECLKAVDFIPESGRARLESFIKARSEWCVSRQRAWGVPIPALYQENGTAILTDESIEHVISVICKRGIDAWWTDSPEEPAWIPPWLEGSFRRGKDTMDVWFDSGTSWSQMNEQADVYLEGTDQHRGWFQSSLLTFVGGSGKKGAPFKALLTHGFALDQAGRKMSKSIGNVISPNQIIDCSLLPPVKKKKGPLVSQTLGVDTLRLWVASCDFTRDVFIGQEVLKSNHSALLKFRMILKMILGSMQTPRDDFQITILDQIALTQLEMVMAEVESSYNKYEFYQVVKAINKWVNTELSSFYLEAIKDRLYCGDGGSVLADIFHGFLRMLTPITPLLVEEAWSHRPEWMKARGDVHPCYVTQPKPSMVADDIDFQSSIKSDIPWLMNAARAIKVAQEQARALKLIGSSLESSVTLELPPSGISIFSRYMSDLENIFVVSSVEIGTEPEAEWKFSSNFDLPVGHATAWITAPKDEKCPRCWRYVAPEQDKLCIRCEEVVTTLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAD7</accession>
    <name>A0A0B1PAD7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000481">
        <property type="protein sequence ID" value="KHJ35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAD7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAD7"/>
    <dbReference type="HOGENOM" id="CLU_054588_0_0_1"/>
    <dbReference type="OMA" id="DIVLLRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42674" checksum="B9E44A1CA6449BBB" modified="2015-03-04" version="1">MTPKIIIFTGAPNTLSLDWDESNLLSYFQPSIAQFCGKETMGLSEVMNVSQPSWRLLSHQRSHYMELDPENFDNSRLSQCDSQEALDNILPIITSKKDLFTQKFPQNLEISESRMSQHDGEIFSQFYEESYIRHKDKILPLSICISEQTSTTNSSINNDDDSSLNSSLDLSLSLVENIPVSDRLTDLKDIPSAGYIDSIYPQTVTCNIIVGIISITEARAIKTRRGQNLELIELLVGDETNSGFKINFWSNSLSSGKKPAESINVLYELKTQDIILIQNMALNSFQGNVYGQNLRKELTKIYLLDRYRNFGLKCTRYNGCVNNSNKIEFQNLQFAKINRVLEWLVRFVKVDPAITRRKEIAQELQTEELPPDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAP4</accession>
    <name>A0A0B1PAP4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000281">
        <property type="protein sequence ID" value="KHJ35757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAP4"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="229" mass="25947" checksum="211346D705D3B409" modified="2015-03-04" version="1">MSNAKLEPASNWLSLLIPTVSSCILKEQGLTEVSKEMLSDEIERASTMRSMTLKLFGKNNPDAPHRTWMAYISKAPRSDFMVFDESGKVRPFKKPQAIDFYKRCNGHHSPKNCSRAPSCGNCGSTIHPEDICMALTKFRNCEGPHRSDTYKYLARPTHSGPLTKKQLKVFRKAGDREYQAIFRAKLAEDRADEIKERVETPHIDQTESTKIERMLASPVVVSTEDAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS5</accession>
    <name>A0A0B1PAS5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000864">
        <property type="protein sequence ID" value="KHJ34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS5"/>
    <dbReference type="HOGENOM" id="CLU_041473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45770" checksum="704496AFB9069F06" modified="2015-03-04" version="1">MSSNRTCTRCLQSQPSINYMKNVASNTYFKTCSTCRNRDKARRRNTLQRSPFETSNLQDEVAESSINNQVIVNTIPNNQCSDDGNMIIENTNVAFGNANFIDPSFHNPNDSNLIHCKGCKTNRNPTSFYDSVRNRSFKRCHNCRRRDYDRRHPESLRDQPDTRPQQTISLSLYPPSVEPFNAVTDTVNVRCRKCRKNYPSELFANPGSNSLYATCLDCRTEEHARRYPTVFEPTTIQGPSEYLDVDDADDEEVEQLAANIGMFEIVEEENFNGPVPEEAPLGDDPIFMLSQIQSREFRNHDEIQKRLQADEEINGINNPDGAPQVDDPNIDPFLEELPQAEIYNDNNLENVLLNDPFVEENSHAQNNVVQSQSYLQIDPFLESNPPPQAEGEVIEAPPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT4</accession>
    <name>A0A0B1PAT4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclin-like f-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAT4"/>
    <dbReference type="HOGENOM" id="CLU_048311_0_0_1"/>
    <dbReference type="OMA" id="FFDMPNQ"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080579" evidence="1">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="35063" checksum="E325F66C6B0C4801" modified="2015-03-04" version="1">MMLNVMMPYLRFLFFSFVILILPVYSIPKGDRTASSKAANTLGNRKVTTATDGSMILDKTVMINGLPIRYKVSAPADQFTTSSGVPGASAQPKSPGTNGLNVLLHGDGGQSFTDFPNQAVQENLMGVVVLAPNDKRFWGGGSGLQRTDGEAHAAAVNSLIQDQLPQDVAFDPTKVFFTGVSGGSLLLSGFFVPAYGDTYKTGVLLNCGGLTPQVPVVNGPDMIANMKIHFQSTKKELTLLQPELPRAISAYEKIATDAGLSPDQIGKLQTVDNTPNGGHCEFDGKDFVTGVQLMSSNYANIIGNNPSGNVQGIGNVLTSVVGNEKLTFTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY9</accession>
    <name>A0A0B1PAY9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001232">
        <property type="protein sequence ID" value="KHJ33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY9"/>
    <dbReference type="HOGENOM" id="CLU_2322088_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11078" checksum="E766E254B76A44E1" modified="2015-03-04" version="1">MSPAFAKRENDKIRNAKFMANPLEIHSLNKSISFDGTKIQMKNKNIYVLSKGQTESIRLINENSVTAKDVYRSQRVRGAYVASICQPEASYSLSAAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB96</accession>
    <name>A0A0B1PB96_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative actin-related arp5 class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000368">
        <property type="protein sequence ID" value="KHJ35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB96"/>
    <dbReference type="STRING" id="52586.A0A0B1PB96"/>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000054">
        <property type="entry name" value="Actin-like ATPase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="746" mass="85137" checksum="9C14C73785F1BA85" modified="2015-03-04" version="1">MANSQVEQSLSLEARPPLKTYSPREVRFRQITEDFCNGYKNARLNESGDSIIVIDNGSSAVRAGWSFDKTPQINTAPILSKYRDRKLNRTYAFVGADAYADTTARGHVRYAFEAGSGIVSNWDVMESVLDYVFIKMGIDGHSGRIDVPIVMTEAVANLPYSRKTMTEIIFEAYRAPSLAYGIDALFSYNFNNGKTGLVVSSSHSSTHVIPVFNSKAILSQATRLKWGGSQNAEYLLKLLRLKYPNFPGKITNLHTESMVQDHCYLSKNFDEELANYLDWNYLEQNDHVIQFPYTEEVVIQKTQEELDKIAEKRKESGRRLQEQAAKMRLEKLMRKEQELDYYRSVQERLDGETKKEIKRILDSEDLKNEAALEKLIKELDKSIRKARTADVGGPDIDEEAEEPDYSLLDIPDDQLDEAGIKQKRHQRLMKSSYEARARAKAEKEREIARIAELQRVDKEKRENDREGWLQERHSARLDLIQRIKERDRLKADLGNRKSLASQIRMKSIANLASDNPTKKRRRGGDDDNFGANDEDWGVYRQIAVGEAGSDEEEEEDLGESLKKLEADLLEWDPDFTEQHTLEAQKDWTKSLIHAFLRGPRPFDPDSQSEINQIHLNVERIRVPEVIFQPSIAGLDQAGLVEVTTDILIHRLSGLGCLDTFLKDIFLTGGTVMLRNFDERLREGLRGSLPSGSLLKTRKAQDPILDAWKGAARWAGGTEWKLAAIKREEYLEKGSDYLKEHSLGNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB99</accession>
    <name>A0A0B1PB99_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative u-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000177">
        <property type="protein sequence ID" value="KHJ35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB99"/>
    <dbReference type="STRING" id="52586.A0A0B1PB99"/>
    <dbReference type="HOGENOM" id="CLU_056455_1_1_1"/>
    <dbReference type="OMA" id="WAGVEHD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="212"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="33535" checksum="D06BF3D396559FB1" modified="2015-03-04" version="1">MVNQDLPHDTRAAIDFKEQGNKYFKSGDYTRAEMFYTKAINCDPQNPVLYTNRAMVLLKLSLHHRVIEDAQCALRLLPSNMKAYFQLAQAQLALNYYDEAFQSAKTARKFCMEEMYAGTKGANSIEPITELVMKCKKMGWEAQESKREMNRSKLSHELQYGLEERRDKKIAEFRNSGHGNEEKIKETMDEYQGLIEEFKRTWGIATGEKKREVPDWCIDDISFSVMLDPVITKTGQSYDKASILEHLKRSETDPLTREPLYPRDLRPNFALRDACEEFLRENGWAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBS4</accession>
    <name>A0A0B1PBS4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nima-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBS4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBS4"/>
    <dbReference type="HOGENOM" id="CLU_010063_1_0_1"/>
    <dbReference type="OMA" id="VQDCGHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062028" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111642" checksum="314120D5A994A5BB" modified="2015-03-04" version="1">MFNLKFPTLLLICIVLLLASPVAAFGAGNIASIAKIEGTNWRHGDIEDTLLSLLIARVAGGKKFDKVNVSRVYFGNWLRDYSQAIDVGTVKYVSAEAIRILLWVLGFLTFGYGTKEFEVTAERLGCYRPEDHIDNPKDYADNVDATQFDARFRGPVNEQVELAIDPRSGMKNYIANESVGIMTSALHVRRLFGECIRLGRSYAQSKNKDELYEALRLLGTGLHCLEDFAAHSNYIELALIELGEHDVFPHVGRQTKVQIQGARGPVFPITTGTFGGVDFLHSVLGEFNDKATQSEIQELEGAIKQDSKGDFSLLKDLLGKIPKGVFEGKDQASRADELKSNSTNAQMDNLRVSPRQPEHFTRQMQDMTRQIYPILEWHDDTMKSITKAIEKIPILPEIMSKLEEQINIFVFSLIAPFLLPLINQVKNELNTGSSEIIKSSKDKQFIVFDDDYSSDPTHSMLSKDHFSNVLNEPAGKIAAEVLKWVVPQLMQCWDDSRIDVDRTLNRILQGSLNHPALRNQGEDGAADGRQIMFRVVENWWNSLNNQEKYKMRQNLSRDGVKNGKNHQGTPDCGHGCGHPIKMNKTMGDIKPGSGAASVAMTGLSSVLSGKNSSSGASSVGKIASKAAGGGVLGGLVGAIAEGIGGSLLSGGKRPNTQNSGMSDYTEQENYKLNSNESYAPGNQDTQTGYYKPQDQNYSNTDQYQANNQSNSQFGGRTDEYQSYNKPCSQYSGRTDEYQGYNQPTSQYSSRTDEYQGNNQSNSQFGGRTDEYQGYNKPGSQYSGRTDEYQGNNQSNSQFGGRTDEYQGNNQSNSQFGGRTDEYQGYNKPGPQYSGRTDEYQGYNQPTSQYSSRTDEYQGNNQSNSQFGGRTDEYQGYNQPTSQYSSRTDEYQGNNQSNSQFGGRTDEYQVYNQSGSQYEGNSYGQQYENITNFAGGYDQSNFEGKGHRKHHSKHKNKVSEYGIGDEYCRDEDAGNSQNQQSYYSGRQDSYSRNDYGGNTNSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBX7</accession>
    <name>A0A0B1PBX7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000859">
        <property type="protein sequence ID" value="KHJ34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBX7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBX7"/>
    <dbReference type="HOGENOM" id="CLU_710170_0_0_1"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="389" mass="44323" checksum="4E537B44E7C49DA3" modified="2015-03-04" version="1">MAQIFSQSALPPLQEQLSLLQNIDDIYTTQRHHFSMARRHQHSDRLFQHRRNYSKSPSPVLNSRIVHRPSLQEEREEYRAYQGHDQHRESLPSFSSLLNGIKESTNQKNESEYNGCHSTSNFKPLSSDSYFPAAAAFKSREKQRSTTQIAKIQSNSQTYSSDYRFVNSTNLKSSPPQPLPLLITRGPQSPIHDIRRTMVDSYSSQTPYSIGSWSPNSHSSFLDFPGKANSSPLKIDTEHTPSPSHRPEPARLKVVESENPSAQTTNYLTSPTVTQDSTPTRNGLGPKIWAGNRFLPQYTHEAYVPGEGTCYFYDDGTRCKSIIDGEVVNKYWGITKTGKPRKRLAIACLTCREKKIKCDPDYPKCDQCKKFGRTCVRKRLIRSESHDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC08</accession>
    <name>A0A0B1PC08_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000267">
        <property type="protein sequence ID" value="KHJ35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC08"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="382" mass="41642" checksum="8B406C415A151D8D" modified="2015-03-04" version="1">MDISQESQALPTESSHQPPPIPPIPPIPNSPSPFAPPPPPPLNLEPSAKMTYGRQILKPVALSKRPIIERPTPSSSNNFNTENAFLPKELADVIATRQRRERAWHARLMLCTTVISNIDSTLAAFIDEIEKEEAAALKAYIQVAIANFAASDSKPTPPKIPSHSRPKKSNGSSTTNDKNVMKKITIVTPRNLVGTALNNGKSQEAIKLPAVHQAGERTWAVVARNGQKKARISLNTSKQGNSATKSIPRQPTKDKFPKTAPTDNRLFVRLPQEHEWRKLSPAGIREVVVQKLSISPSLIGKIKPVQSGFALSPCSKEARESILNAGNGLFLTGAKLEPATNWIPIIIPTVPRSIQMVKGQVEVSTPCLLMRLSEFALLGQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC43</accession>
    <name>A0A0B1PC43_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000258">
        <property type="protein sequence ID" value="KHJ35783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC43"/>
    <dbReference type="STRING" id="52586.A0A0B1PC43"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="30297" checksum="7445B1C8CB673632" modified="2015-03-04" version="1">MPVIKQLAYSFSGQRSKGKVVIITGANSPLGIGRASAYQFAQHGAKAIFICDIDNSCLESHQHEMESLYPPVKVHPRQFDASDKSAVKSVVDDAIKLYGRLDVFFANAGIVGHLKPFTKIDSDEFLKTLKVNVISVHLAAKYAAPAMMITSEEKKISSGSIICTASVAGLRSNAGPSDYSASKAGVISLAQTLAYQLSGTRIRVNAICPGLIETGMTASMFEAARAKGNEDKVGQLNPLRRGAHADEVARVAIFLGSDESSYVNGQAWAVDGGLSAGHPFIPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC95</accession>
    <name>A0A0B1PC95_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase family 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000807">
        <property type="protein sequence ID" value="KHJ34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC95"/>
    <dbReference type="STRING" id="52586.A0A0B1PC95"/>
    <dbReference type="HOGENOM" id="CLU_002351_3_0_1"/>
    <dbReference type="OMA" id="HSMARIF"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="862" mass="97728" checksum="319198F63B5AF73E" modified="2015-03-04" version="1">MAQPTIDKEAIVQTSLMTQHRISLSFSDDSMDETILDPIGEYPGLNFSGNVISVAFCIPYSLKYVKGSEWRLSPRRGKSALVDSFTYLSSEKTPWNHTLVGWTGEITIFEDQTPPPTPPVNPSSSRYMPLNKSSAPIPVDAFTNPPEPLHIEGLWIPKQDQDQLNQQLFNDKICRTVPVWLQDKQESTADGILLKDQTRWRRFAERNLYTLFHYKQNEATDGITERQLWEDYHHMNQQFANCILKIYKPGDILIIHDYHLFLLPSMLRHIVPRMYISFFLHIPFPSSELLRCLPRRKEILEGALGADLVGFQSPSYSRHFVSCCTRILGFPTDIMGVETDVRKVIVGIFPIGINAAAVEKAAFENPLVDEKVEALNSLYKGIKIIVGRDRLDTLRGVSQKMIAFERFLADFPQWQGKVVLIQVTSPTSIEGEAEDAGNRITKKISEIVANINGTYGSLSFSPVQHYPKYLSQPEYLAILRAADIGLITSVRDGMNTTSLEYVVCQRDRHCPLILSEFSGTAGSLKHAIHINPWDTSGVSKQINAALTMSSDKKAAMHRSLYHHVTTRNIQAWADNFLRRLLVVLNGIKSVVSTPLLDKDLFLKQYQASSRRLFMFDYDGTLTPIVHDPSAALPSKFMINTLKTLATNPKNSVWIISGRDQAFLQQHLGHIRELGLSAEHGSFLRHPCSLTWENLASLIDLQWQAEVLETFRRYTQKTPGAFVERKRCALTWHYRPSDPILGAYQADECRKEIERDLGKKWDIEVMTGKANIEVRPSFINKGEIVKRLISEFDPKPDFVFCVGDDFTDEDMFRELKAANLANGHDFIVKVGKSSQATIASWYLPEPEDVISFTSSLCLNENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCG1</accession>
    <name>A0A0B1PCG1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000191">
        <property type="protein sequence ID" value="KHJ35948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCG1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCG1"/>
    <dbReference type="HOGENOM" id="CLU_010348_6_1_1"/>
    <dbReference type="OMA" id="KFWRCGP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="465"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="609" mass="68691" checksum="0090BC1879AE9AF3" modified="2015-03-04" version="1">MEEKKRLLIYVMRRDLRVADNPILFELATNGKKHKFTHLLPVYVFSAQQIEVSGFIDGEEKCPFPEARSRIGGFWRCGPHRAKFISESLEDLKESLEEIGSSLCIRVGMIGSVIEDMIAKFATENFKVAAVWMVGEDASEELSEETAVKNVCRAANVGFKIWADEKYLVDDRDLPFDDIKDLPDVFTSFRKSVEPLRTIPRISLPTPTKGSLPAYPETIPPQQPPFNIPSSFIDIKKALLKPLKTASLISHPPEFPVGASSSFPLQGGCTHAEKHLRHLLLSSCITNYKDTRNGLLGVEYSTKLSAYLALGCVTSRQIHHELLSLENGTDPSLSSVEGYGAGENSGTKATRFELLWRDYMRLCTRKFGPKLFRVSGFRNQKEYRPIWNSPSKPLPGSSINQVQEIVERFLNGTTGMGLIDAAQRELYLTGFTSNRTRQNVASFLAKHLKIDWRIGAEWYESMLVDHDVSSNWGNWQYVSGVGNDPRGEDRVFNPVKQAIDYDPHAEYVMTWCPELRAEGLEVTEIFQPWTIPESKRESLRLKGLISVEKPLRKIQFGSQRKSGGQSHYHQNPRNGNNRGRDSRRGKTQVDDYGGRGYGSSKAYTTKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCR7</accession>
    <name>A0A0B1PCR7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative u3 snornp protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000159">
        <property type="protein sequence ID" value="KHJ36053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCR7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCR7"/>
    <dbReference type="HOGENOM" id="CLU_026025_3_1_1"/>
    <dbReference type="OMA" id="YAKLEMI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="46433" checksum="B2A4EB9311DE5ADB" modified="2015-03-04" version="1">MSGPSDKARFYLENTIPQFQEFRAKNIFSDDEIKALVKKRSSFEHRILSRGCQPIEFARYAAWEIGLEKLRKKRCKRLGIKSFMHNGQAKIFNIFDRGTKKHPGDLSLWISYLEYLKSVKANKKLKIVLTAALRLHPTKSELWLYAARWSLESEINMNGAREFMIRALRFCGNCSELWIEYAKLEMIHLSKIEIRRKVLKLDKQISDSIVLDISLPHDPTFDDFKDMIPVSDLEIDSLRSDLVEATDVETEAAKDHLKTPALNGAIPLAIYDAAQKESFFCASVAVRFFDMFTSFSEVRCLSKILHHVCETMLKLYPNDSLILDCYSRQPMIGKNYQSPGFPQALGHSLERITESLEKVNDKAKYSQLTSIWINKFLGFVDLDPGIRKVLQSLLRKVDLHKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCT9</accession>
    <name>A0A0B1PCT9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative proteasome component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000153">
        <property type="protein sequence ID" value="KHJ36073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PCT9"/>
    <dbReference type="HOGENOM" id="CLU_000880_1_0_1"/>
    <dbReference type="OMA" id="CRIKDIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055444">
        <property type="entry name" value="ARM_ECM29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23702">
        <property type="entry name" value="ARM_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="ECM29 ARM-like repeats" evidence="6">
        <location>
            <begin position="682"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1833" mass="206891" checksum="5B318EAEDF4D4D47" modified="2015-03-04" version="1">MSSETRELDLCGKVEMRIALSEDDKLESILKTYLAPLLLKLASEHASVRNKVISICQHIKIRLSGNQNVLLPIALLLKQYKENLDSAMIRHFDLMFIQLGIGKLSPKEKRELLPMIIIGISDDCGKPTGAHIFNLFLRLLPEFKLPLRGSKEDSDLRVQLKFDKNPADARFIAEWLGKLMLLSINRSAVTDNICPGLNSVEYEFLTLNRREETWNFTCDTGLNLTETKINALNFLSSGTFLDSERFLPALFATADSNSRISNIGDDLLKRSTVSLEDSVLISRIFDMYFVVRPILQTRFLILLSKSVISTSFTSQVLKIAHEAIKPKKNTNIPKKGLETVKFRNALLSYVNWTSRVATKDDSDRIAPNLFELLKSFIEEQGWPILQEKSTDILSLRALAYETLGSLAKSSPKIVREENLTIVRWFFRSLTEEKSSDEVIVSIEGALSCLLGVFVAPLDRNLTSELRRHLFKYMTLEENDTIVRSSFFTTVRWANQCLEYNDVVGRWIDILAIGCGSSHRKDVVEEGKKGLNPYSYKILNSLPSSSKISLPNWEELIKVLFKSEMLIENSAEANCLKTGMSIDSVSIFGNFSGHRIDAFAPAVIYCRQLLLLTGLEKSMTPVKIDIDWELKIDLLFRSDKKIQNSMKDYIKSIDEDVYYTYLQATFEGMIRNDGNGLSGCGKCFAELISISPQKIVGKFSDQAFKLMPAIESNNHTTRFLAARAYGIIIPNPTQERNDIDGVIKNLLREILSWESAFGAHANKIHGYILALGFILSRISYYQRSDILESQLTKDAILVIIKIFLTVGNHSIKEAVLNAIGEISIAGLLDTSFIENAKIDMTQIIEILSIAALKGDEKSISTLGRLSLIFEDELIESNEKKSHLSNILENLYKLYDLKQYEIQFVVGEAITCLAAGWESNVLILSWDVDTLCTGRLKRKYILESVIQKLLEDCKNTKPSLKKASAIWLFYLIQNCGHLEEIQKRLRQCQAAFMGLLSARDEIVQETASRGLSLVYEQGDKILRESLVKDLVSSFTGSNIQLKVDEETELFEPGALPTGEGNSVISYKDIISLANEVGDQSLVYKFMSLASNAATWSTRAAFGRFGLSNILSESEIDPKLYPKLYRYRFDPNSNVRRSMNDIWKALVKDSTKTIDLYFHEIITDLLKIILGNEWRSRQASCAALADLVQGRDFEKYEKYLHEIWYVAFKLLDDIKGSVREAAQSLSVLLTNILVRQIESGNYSSYAQSMLKEVMPFLLSEHGIDSSAQDVRAFATITLIKIIKHGGKALTVFIPDLIEKLLGLLSTIEPEQINYIYQRAIDQRHKIDEIRSSAVSQSPIMEAIERCLDILDEPSMESLAPRLEQLTRSLIGMPSKIGCASVLSILATRHSFIFRKYSDKHLKAVEKAVLDPNNSISVAYAKASGYISRLVSDKALISLATYTRTLYFEAENENKRLISGEIIHAVAKFASDRFNSMASNFLPFVFFASHDSDNEVRQLFEKTWLENVGGSRTIMLYSNEIIKLSIDCIESPSWTTKHAAALSIADTIESLASCFSDSLAANIWPALEKALALKTFDGKEKILKAFLKFVKHGSSSWKKDKIIESKLKKIIIREAKRNNDKYRIYAFEALGEFSEAQSEFDIFDDVLQIIMPFYEEFICEDKMIIGNEETESSKESDEFIVLTAGISSLFRAVNFKISDPNPLTHLPQLVKIVLGVLQSRKVTAAIHIVIFERIDCLFNDLRKHLFQSNFVNQYDIAWQIFNSLELGKDFGYESMRLKRAKACDAIVQAFTSGVFGSSLEGKVDCANKMKQLIEAGLTIEISPEVRKILETTLKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD01</accession>
    <name>A0A0B1PD01_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000477">
        <property type="protein sequence ID" value="KHJ35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PD01"/>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="OMA" id="SWMNATP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057068">
        <property type="entry name" value="IML1_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24438">
        <property type="entry name" value="IML1_N_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1633" mass="185926" checksum="40F9806157C2C93A" modified="2015-03-04" version="1">MILKSPTMSLERKCTVWVHDDIFSKEPVIINLKFFENIYPDDLLSVSPLGIETFPHDTPGNISTQESGEITSEHSLHLGSRYLFFARTTQGATIPGLEISVSKQVADTFGLKHRSNVIISTADIEASTASHVELSFKDECLTRCDMWRLALSELSGKVVFKGQKILFMGCIKVHVISIYLNGRKAKSAYFSSSTVPIFRSSSAKYFLLIQMSKEMWEFDSEGTGEIMFNKVISGFLPTLFKKWAALKSEHLVSIILFTRVEYGTDITTGLVSDVLGDTYFTGIESCGNKRPYKDFFRVVVYEMASGSWTTILYQLKREFNLFRRDISMHHINFIKSRSIATSEKSNVASTGSHFEAQASLAMYGNVLEAIDLTCYHFTCEHTNQDLIKTGNSIVIITPCAGLFEVDHDILKLTSEMLVSNRISVDLVCLPRMPLHSAPLFRYRNPEHVCFMEYLKLKILDNDHTPRSHVGLTRSYSTPQNSASPVKSLNTNKNFQVGFSMSSKIPDKWLFAIPNWLNISFWTAPSHNVNNSKFSAQLKLQKFGDIFPYRPTDFAVRCKMYEMEMAGIIESVFTEISVAPLNHDPLFTEKKGDVSCKQSNIIDRKFPYAGLSELISISSKSLDEKGFTQSIYDTYDLVNSCIPGESYASPFKVKVKKSLRHDGDESLNKNRQNEQASICTGLGNYICFNNRNSMVSGKLPRKAKSRHFPRLMAPELYGTEKDRYATSISTKTSDSNKILTGPSNISRQICLGKYGFGITAPTTATVEIHTENANAVSTHSSLCGPKGIDIKSIMGYISNNLRHTPKSTILKRKSIHEETFKKHNPTPSLDVSIESIGQVKAKLVPDKSMTIKSALESLDSTNQVQTQSILDPYHEWSDLKIGSHIGALPHRFNDSRLTIGSVPKNNVKLSPDNSLSPWLNVTNPSESILKNELSSGLYRRCQPVMANSKLIETMKWKSLCFPASITLTTEYFPTKNELETEFEQKPYKISQNTEDEYGNEIPRCREGLLRELVGLRLSQGFQIIGSPVVAEAFGQKVFKVANIFEFNNTTEDGISVFMSMGNVIHQISCVNDGEFEINIFVHKSSKLDARTQGLVYHPAIRTKLSQTYESQPIFIGRRKEHYNWNYVDTYLGGFHEEISESLCFYRARFVLVPIDRPAQALKNACEDNEEELRLEGIKKLTQLWQRHKATQSSEVRNCNMTPCRCKDPNPLDIVYKTDDPSLVVAAELETLPIIEIGDSGLWKSQLLETERFRKSKFDISELAEAIQAPIDKGGVRMQNRRWHLRLYNNCFIGSDMTTWLIDKFEDIETREKAVEFGDRLMAKNEQLKNNEPDNEKNFGLFVHVDSRHKFRDGQYFYQIAEDYAKQGTESRNIWFTSKKQDLFFQSMPYGENLSKDPSGLVHSRSSLSNEKIFESDKKIPKILNTVRKPKVILSKVMRYDIDHRKRSLRPEIINLHYDRLHNPDNCYHIRIDWLCVTTKLIKDAIESWALITDQYGLRLVEVPIDEISSINSINPFRNAYRIKIFLLPPCQIPKAFMNINTFSPQPPSISRFTCRYECQKAILKKFNFVLDTEAAANFPSHVDVSYSWGKPQYKFSQYIHRSGVVLAQITDDNHILISTNRLFFNRLVPSKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD06</accession>
    <name>A0A0B1PD06_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative telomeric repeat binding factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000472">
        <property type="protein sequence ID" value="KHJ35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD06"/>
    <dbReference type="STRING" id="52586.A0A0B1PD06"/>
    <dbReference type="HOGENOM" id="CLU_008791_1_1_1"/>
    <dbReference type="OMA" id="EIACYIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere repeat-binding factor dimerisation" evidence="5">
        <location>
            <begin position="113"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="564" mass="63807" checksum="5B386CFE1CC99661" modified="2015-03-04" version="1">MIDGEATIKHESSDSFDSNYDHGTSIQKSGLKHDLSDYHTSTVDKRLKIEARETPESSPDLAAILANVSACTPEQRLTHEKEVQVFLGSKNLESANSFQEKEVVSESLSFMRILSLPMLENLTTQIISLLTRKNVHDIITIVNTRDSELGKAYHTLKSLFDQVKNIYSQCGLFLSADALNITEPKHREIIRIANLTTFVCCVFDGNEVGFLDLNNHFIEIFAAEDIPLSKEAGDLFLNLKTQIYLSAISQEEQERTREDLLEEYFPNNLEEILKRRHPNQPLSQSEYEFTRLLINRREFLASTPIDLDSIQILSENYSWEGFLNQVAVFLGKISLLAPFLKSYGLNVSLPVSNGQNTENLQPVIDDDLGLQVELAAKQTLESLGLNTAQLQYERNLHEDFYTIHNESYHPEYNSLSLPTEQSAPTQVLYERARHAAVAKNCPSSTRRPGIPSHRRPWSSEEERALMAGLDQVRGPYWSQILALYGAKGTINEVLKDRNQVQLKDKARNLKLFFLKSGIEVPYHLKAVTGELKTRAPTQAAKREAEERARLADIDDLDSELSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEI3</accession>
    <name>A0A0B1PEI3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000555">
        <property type="protein sequence ID" value="KHJ35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEI3"/>
    <dbReference type="HOGENOM" id="CLU_045443_0_0_1"/>
    <dbReference type="OMA" id="FMESLKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="389" mass="44107" checksum="456989E7C1537E94" modified="2015-03-04" version="1">MADDYPSFSSNFLMSHFQPNAILRGAQLTIVGALRALRNPSLLTSRHYKQVAIAIACGIAIRIAIALPVLGIKVLLWLTSFVFDYEYVSWSHNVANGLGFIQNSVLQVPFFLMTVMRNITPTLDEMFMESLAWVDSTYYKKHEGENSASIRNGYYENLSKYPTRDIYAQPKSAAYKLKKLISWSSKKAGISLLIFILSYTPVVGQFVLPGASFYTFQKVIGLAPAGLVFGIGIFLPRTFLVIFLQSYFASRNLMRELLEPYFCRIRFTKTQKKNWFHDREGLLFGFGIGFYLLIRIPFLGVLIYGIAEASTAYLITKITDPPPPPNKSEGYAATQQYWTTKIDFLRFSFSEIDKNTHSKKTLPTSNLASMSFSNDSEPPPYQEIEYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEW5</accession>
    <name>A0A0B1PEW5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dna repair protein swi5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000228">
        <property type="protein sequence ID" value="KHJ35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEW5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEW5"/>
    <dbReference type="HOGENOM" id="CLU_480754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="567" mass="62727" checksum="181C296953CDA3A6" modified="2015-03-04" version="1">MSRKKLTFPGLSIIMTNNELETEQQKTFNTTNEGRARIIVENGEESFKYLLGSEIGDSDVELVDSSIDSIDVNQQSGSRSSRNTDHGLEYFVSETITNKKIECKLPKEKDMNFNEIRNENLLNINDSSLVASNSKIMRPNLVPPSTSEDGSFATSELSSIYNGNNRLALAPEQKPFFCTEHEPKFMDIEDLKALPLNTSTASSSPRCSNEQIWPSSQDNMAMFDISDQNKQESSINTHNPFFSGESTEFNFSPTSNKKVVTCLSQDTKPDENNLRIEDRIIISNSNDNKLNVGVEASFRRQQSAKTDLKSVDVPEQKLLTPITTLSTNSDVYKASLQQDRINNNTLSTPDSTKELHISSSEQLVSMEPILFSKNEHSVPVSHIAANEGSSLSLVLPRSALTTGLQNSEAVLTTKLISSMAPQVSDTEQTKVFVPTASPRSFSLHENVESSPSSGLSISNTSSPPISEVSPERAREVMLAELKAIKIASITTRNTALEAELAIKNARLEEITRELRVPAQETVRRHIKLLHDYNDIRDIGQGLIGMIAEQRGVQIGSLYEDYGVGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG28</accession>
    <name>A0A0B1PG28_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial 2-oxodicarboxylate carrier 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000352">
        <property type="protein sequence ID" value="KHJ35554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG28"/>
    <dbReference type="STRING" id="52586.A0A0B1PG28"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="34850" checksum="BF3B90AA8061376A" modified="2015-03-04" version="1">MTSEKPLSFPYQFAAGAVAGISEFSQEFQIFDFKLISCRYPLDVVKTRIQLQSNKSVQINPYGGMLDCFQKIVQNEGFARLYRGIEAPVFMEAPKRAIKFAANDFWGKFYRDLFGAIEMDQRLSVLAGASAGASEAFVVVPFDLVKIRLQDRVSAMKYSGPTDCLIKTVRTEGFLALFNGLESTLWRHIFWNSGYFGCIFQVREILPKSDTRKTRIINDLVSGAIGGTVGTILNTPMDVVKSRIQNNPKIPGVVPKYSWAWPAIMTIFREEGFRALYKGFLPKVIRLGPGGGILLVVFTAVSDFFKNMAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGF8</accession>
    <name>A0A0B1PGF8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000187">
        <property type="protein sequence ID" value="KHJ35956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGF8"/>
    <dbReference type="STRING" id="52586.A0A0B1PGF8"/>
    <dbReference type="HOGENOM" id="CLU_027543_1_2_1"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="107"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="362" mass="41232" checksum="94EC6DDEB909F6CF" modified="2015-03-04" version="1">MILRSCALQGRIVSLKQDSNYLYYKSIWPSTNSLNLPSTASKIGDDCVQDEDTKDLLQRYLNLEPNLKSYYEYWSLVDPNFKKRARMFSGVRVLRQDAWEALIGFICSSNNNIKRISQMVGNLCVHFGRYIGHIGDEVFYDFPTPEVLAADGIETHLRDLGFGYRACYIAQTAKSITYSKPQGWLQSLCNYDPFDRDLDHKQTLCGGRKGYREAHTQLLQLQGVGPKVADCVCLMGLGWSEAVPIDTHVLKIAQRDYKFESAKYKNLTKTNYLAIGDFFRTLWGREAGWAHSVLFAADLKDFSGRLSVTSGIPGVSATKSLETVALKRYLEIDESKIEVSKEISNFQVNKIRSRKVKRRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGI5</accession>
    <name>A0A0B1PGI5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000057">
        <property type="protein sequence ID" value="KHJ36355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGI5"/>
    <dbReference type="STRING" id="52586.A0A0B1PGI5"/>
    <dbReference type="HOGENOM" id="CLU_012201_3_0_1"/>
    <dbReference type="OMA" id="CETYNAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="921" mass="101123" checksum="E0205A9ABA21015C" modified="2015-03-04" version="1">MNMKILLHVNHPLRTRIFNRLYQPFAQPKRTLINALNRDLIATADNVAFHKNLLKPIVALESALYTHLMLYPDNFELARHLQNLIRGTGATPATIGVINGVAKIGLSDQEIHTLCIAAGKLETLKISRNDLSFALGMGIAGSPVNGGTTISSTMTLARWAGINVLATSGLGDVHLGGENPLSISADVTELGRTPIAIVSGGCRNFLDTRRTLELLETNGVLVATYSDGRAANINFPEFYSRDSGIKSPRVFHDYKEAAAIIFSLAKLGTRANRFSRSGVLFANPVSENFSIPRDEIKKATFQAIDEVSNLNIHEHEAARFALNKIRDLTNGRSNIVSLASIESNVILASKIAVELASFWKMDLGCKESLNLNISGQNTKIVTEKSKLKSENYGYSNFAHPRISKHIAHSNNLYEAKVNALKTNDTLGLNIKPNYHPNIVIIGAVVIEQTCDFILSPNAAFDTNLQPSLRSLNHSRIEHTVGGVGHDIALAAHLVSGDQRVRLCSLVANDLSGSTTVESLKAETLDIHGIKVLPKIINRSGQDIQNRTAHCVLVNDGKKDLVLGMTDMQIFRHNSYECSNIITENLKWAVIDANWNRKTVRGLMSMMRNKCPWTKIAFAPSSEQKGADIFRTSSNPESSCEIPNALDVYPNHKIDLAALSVGELNEMFCAATSHGYFENNDHWHVLDAFGIMGTQSNDRYKAIAGHELTIQGVPFQTIQLLPYIPKLLIKLGSKGVLLTELLKIGDSRLKDNIHEKWIVSRTRSGHMYIGGVYMRLYPIVETVDPADILSSKGAGNTLLGILIAGLSRGLKLDKNLVDIAQKGAIMTLRCKQAVSPSLGELTQSLDRLALNSENLENQVSKSATSLQSHQGISQNDENNQAFNAPIYHIRNFNFESEKYRNQTETAIENNASVTAKYGLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHD3</accession>
    <name>A0A0B1PHD3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000191">
        <property type="protein sequence ID" value="KHJ35949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHD3"/>
    <dbReference type="STRING" id="52586.A0A0B1PHD3"/>
    <dbReference type="HOGENOM" id="CLU_001040_1_1_1"/>
    <dbReference type="OMA" id="LPEMKGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000281">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000010">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="386"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1272" mass="143616" checksum="8D4F78F13BD285CF" modified="2015-03-04" version="1">MSDSSETHSKNSNHKRSFSTALSLLRRKEAKDDDEISDEGSHSYKSATRHSSISVSNPTTRALPYKPRLSSSSTLIQQSPKILEIPSRVMIQPTAVQEKALSIEQTIRKFRLFEALRNGDTAYISKEIRKIDSHRLTDASITNSPGPSSYLENTTLLHLAIQCAELPVIEYVLSDSTGTIDINTRDKDGNTSLHLAASQARSEAVRLLLKQPGINDSLLNYQGKSPFDLAHTADIFQELQLARSLFIESKIQQVQELVCNNEYETLGIILEEPRVKMVLDINGVEFASDPATIETGGTLLHEAARKKDTALIQVLLLHGADPFRRDQKGRLPQDVTRDDSTRSMLKRSPAAVVAQRGIQEKAVLGNNPQQNNGNISTIDIFAGKDSREMKGYLKKWTNYRKGYQLRWFVLEDGVLSYYKHQEDAGSACRGAINMRIAKLHMDPTEKTKFDILGKSSVKYNLKANHEVEAKRWFWALNNSIQWTKDQAREEERQRQRNAELLRAVKAENSSSSSNKESACDVASETTSIDLRRNSVQINRLNPSTTKNIKTALGNGFSAHDDETAISTRSYEHSFSGDRGKIQNDIDKVHFDMIDNDDDDDDDESDPGASNSKDAYHITAQSVKLQLEVMGQVNTALQVQQDNKPELPISDPSIVSVSQTFDSLIRNLQGLVGDLVKISKDRDAHWQYRIDREINIRRMWEENMATFAKEQELLEAKFGEAEEKRKLTKRALREVIEGKSTLRNASATSPITNSTSGQTINLDQTKVPNCPQSPRAQEIVSAKENETSLQRIDTKYKTLKSKSILAGVGSLSDSESDEEFFDAVDAGEVKLAPKLLLPLSSNPCNHKEKDQLPTISEDYDISSSFRGYEDGIRKKLKLDIDDRPKVSLWGILKSMIGKDMTKITLPVSFNEPTSLLQRCAEDLEYADLLSIAADREEATERMVYVAAFAASEYASTIGRVAKPFNPLLGETFEYSRPDKNYRFFMEQVSHHPPIGAAWVESARWTYWGESAVKSKFYGKSFDINPLGTWFLKLKTINGTEELYTWKKVTTSVIGIITGSPTVENYGPMEIKNWETGEICSLEFKSRGWKVSSAYQLGGYVKDAEGKICYSIGGRWNNKIYARLTPGYEATVEEPKGSNKDSSKVFLVWEANPRPTGIPFNLTSFCITLNDDNPKLLEWLPPTDSRLRPDQRAMEDGRYDEAATEKTRVEEKQRAKRRQREEKGEEFIPLWFSRAKCPVTGEPYWKFNGKYWSEREKVPEGNAWKDCERIFEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHT3</accession>
    <name>A0A0B1PHT3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cdc25 family phosphatase ibp1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHT3"/>
    <dbReference type="STRING" id="52586.A0A0B1PHT3"/>
    <dbReference type="HOGENOM" id="CLU_107716_1_0_1"/>
    <dbReference type="OMA" id="RCTNIPC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="17798" checksum="4CB6D85B96FB3BC1" modified="2015-03-04" version="1">MRPMANINNIPRISSGELSKILLSESKVSANLDESIPPSKTAVVDVRDNDHIGGHIKYSIHMPSNTLDTNITDLVRRLKDKELVVFHCALSQQRGPSAALKYLREREKIQGSEVLNSENCECKSNQRVFILDKGFNGWQKEFGEDARLTEGFVKCLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIM5</accession>
    <name>A0A0B1PIM5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIM5"/>
    <dbReference type="STRING" id="52586.A0A0B1PIM5"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_2_1"/>
    <dbReference type="OMA" id="ILVGPPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005109769" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="239" mass="25372" checksum="E75EC631243D34C2" modified="2015-03-04" version="1">MKASIIFSFFLLFGRMTALPTDIDSLISRDLEASKILVGSEKIVARATAEDTSDDVENELAGECRSVTMLFAKGTGETGNLGSGKSPGPALAAELRKYLGRDKIAVQGVDYKANVLGFLIGGDLKGSKELIDLTNEAATKCPDSELVLSGYSQGAQVVHKAVEELPSEVLPKIKAVVLFGDPFLGDEVGDLPESSVLSICNDKDTICHSGLGIKGHLKYPERAKEAADFIVSKLDAKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIP3</accession>
    <name>A0A0B1PIP3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000068">
        <property type="protein sequence ID" value="KHJ36334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIP3"/>
    <dbReference type="STRING" id="52586.A0A0B1PIP3"/>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_1"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="197"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="427"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="558" mass="60527" checksum="E0F09B0FBA70BCAC" modified="2015-03-04" version="1">MFRTALRQSSRTVSGISTSSFIARAAVKPIRSPASNFILRQCRSYAVEAKASPTEVSSILEQKIRGVQEEASLAETGRVLSVGDGIARVHGMANVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDVPVGIEMLGRVVDALGNPIDGKGPIKTTEKRRSQLKAPGILPRKSVNQPVQTGLKSVDAMVPIGRGQRELIIGDRQTGKTAVALDAILNQKRWNVGNDESKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYIAPFTGTSMGEWFRDNGKHAVIVFDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDKHGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGIRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLNRGERLTELLKQKQYSPMAVNEMVPIIYAGVNGHLDGIPVNKILKWETDFISHLKTNESDLLTTIDKEGALSKDLEAKLKNVITTFTKSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV78</accession>
    <name>A0A0B1NV78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mpv17 pmp22 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004661">
        <property type="protein sequence ID" value="KHJ30247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV78"/>
    <dbReference type="STRING" id="52586.A0A0B1NV78"/>
    <dbReference type="HOGENOM" id="CLU_049109_8_0_1"/>
    <dbReference type="OMA" id="FRVMPIQ"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="272" mass="30691" checksum="B5661E59DACF87E8" modified="2015-03-04" version="1">MEPGTGKQRILTRLNTRCVYGGYSVLHAIVLLLEMASVARLIAKFNNYYADRPLLTMMVTNAILGGIADTVAQSITAIRKTTSRKLEDGQSDDTNDIEFHDLDRKSHLIQHDLILETKAQPAQFDFERLMRFMAYGFMMAPPQFKWFQFLSKTFPVTKESGIGSAVRMVAFDQLIFAPIGIATFFTVMTIAEGGGRRAVSTKLRDMYIPTLKANYVVWPLVQMVNFRLMPVQFQLPFVSTIGIAWTAYLSFSNATEDSEIRPLPQSPNIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVM7</accession>
    <name>A0A0B1NVM7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005602">
        <property type="protein sequence ID" value="KHJ30023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVM7"/>
    <dbReference type="HOGENOM" id="CLU_2279526_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061511" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="102" mass="10701" checksum="FAE25AF94365D86E" modified="2015-03-04" version="1">MQISHTFSIIFFGVLSAAQPIMLDTRQIPDIPAIPDIPAIPDIPDTPGTSSPKIPAIPSIPAIPDIPAIPDIPEIPYGPVVPKVPSVPKVPKVPKVPAVPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWC3</accession>
    <name>A0A0B1NWC3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004636">
        <property type="protein sequence ID" value="KHJ30258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWC3"/>
    <dbReference type="HOGENOM" id="CLU_036943_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31796" checksum="6FBFDBCD1445C885" modified="2015-03-04" version="1">MEVNTVVDAADGPNLDSFEEEDPLRSKSPQKAALISPKPTHTQSDRNQRNVTSLMSAIKGLLDLTNDYLQNLETQYPGIGSDFLALLSDGASHAMPSTNPTWAKIAASQDPANVSFKRRNIKSSPPQGQCKEDRRIMIRLAPDHEARKSGTFELRQTIQKLVTDSSLISDVWNVPSGAAKLASMPVKAAIILQAKKVIEERFGNATVERQETWTTFVIGPIQKQIRCLDGFRDPMDGLLQDELAAVQESVQIRYMNWTRRSQNDEPTGYVRICVREEISSEASGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX00</accession>
    <name>A0A0B1NX00_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004111">
        <property type="protein sequence ID" value="KHJ30503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX00"/>
    <dbReference type="HOGENOM" id="CLU_1251486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="24477" checksum="3C1388D801F9B5E6" modified="2015-03-04" version="1">MKSALVPSLRKGVAYRSNVSMTSYDLFVREVQDLANELESLPDFRLARGSEKEVYVHEILGYQQQISTPTSSTNVPIPPISFPPSSVPSPTPYPNIDHDGDVRMGDINTLQTQMQSLVAAISNLNIHNNPNNRKTEHRPYPPECSQAERNRRVTNGCCERCGKSPSHRWSDCSFRNFKNNPTSRGQGRSRSAYLNSASSIVPDDIFQATGALNSGNGQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX86</accession>
    <name>A0A0B1NX86_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="JNVN01003364">
        <property type="protein sequence ID" value="KHJ30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX86"/>
    <dbReference type="STRING" id="52586.A0A0B1NX86"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="303"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="556" mass="62341" checksum="60159AE493D5B608" modified="2015-03-04" version="1">MKYVLVSGGVISGIGKGVIVHVTSIKIDPYLNVDAGTMSPTEHGEVFVLNDGGEVDLDLGNYERYLNITLTRENNITTGKIYQHVIEKERRGNYLGKTVQVVPHLTDAIQDWIERVSRIPVDETGQCPDICIIELGGTVGDIESAPFIEAMRQLKRRVRKENFLQIHVSLVPVIQGEQKSKPTQQAIRDVGRAGLVPDLIACRCDVPLEKSTIDKIAMFCQVEPEQVIGVHNVSSTYHVPLLLEKQGLVSTISSILRLNDLTIPDSLLNLGQQTWAKWRNLIIENDHLREAVEIALVGKYTDLHDSYLSVIKALEHSAMHCKKKLKLSWVDASHLEEKCRFDDPASFHKAWHVICTACGIIVPGGFGSRGTEGMIKATEWARTNKIPYLGVCLGMQIAVIEFARNVCGFSGASSVEIDPNCEEPVVIYMPEIDKVNMGGTMRLGLRSTVLQDDTEWSRVRKTYNNQKQILERHRHRYEINPEYVGKLSDAGLKFVGKDEKGERMEIVELEDHPWYVGVQFHPEYLSKVLSPSPPYLGFIAAAANCFEETFQNISQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXC0</accession>
    <name>A0A0B1NXC0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003846">
        <property type="protein sequence ID" value="KHJ30633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXC0"/>
    <dbReference type="HOGENOM" id="CLU_018153_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="31105" checksum="63897610D0D37ED7" modified="2015-03-04" version="1">MALSTDGVDGNKKFSQGLLIFLRAAIAQFMANGPGTILPVFPTKPTQNLQVKQKEKSALPSNKALPQKLQNTEDKTWASIARKGNKVTPAIPTLSAIPSSTQKNLRADKEKGKHAKPSTCDHRLFLRLAKEHEWRPLAPSAIKEIICKHLECSLTEILLIRRTATGFALTANDKETRQLLLDKSSMISAQNATIEPASDLVTYNIPNVPVAIQFSNNKVFVTKDMVEAEIKRVTQASPTTVRPHGKTKAVAPYQAWLAHFPRPHAPRVGFRIIDESGFALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXC1</accession>
    <name>A0A0B1NXC1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003312">
        <property type="protein sequence ID" value="KHJ31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXC1"/>
    <dbReference type="HOGENOM" id="CLU_448483_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="609" mass="69540" checksum="B88155F2A4DDFA40" modified="2015-03-04" version="1">MGQIFRELDEIPYQVQWEVNKSYSKRYQSKFKKKQFTEDSKVSKVSNNHGWVTTEDFFKLKGHLRTTINKLAVSKDKLLSNIQGREDKIRLGTLSTAISRSQIKHYFHQDKIITSSGIYHGENECSGIITYPSYQDIKDRSSTVLFSFLSQESNLSIISVKESRSSSSLTQPSSKLNISDPTVDRLEVQADIDRIINTSNIGPKTKPNKLQDQQSAIYSYMSQEQDITIKREQEFSISTNFNLEDSGQRFDDVNFLKAEPNSLTPNKKLSSVEAEKKYLLTIQSSNVLKVSGIDVSKNDRVKIKNDSCSIDGELFRLLDQKHGHIVEKSKVIKISQNQLKKSPTYLTQDLNARSRLQKISNQEKRIDKVLLPSKKDGKSNFQASFQEHEGLEPSVRNASGLKSIESASFLVSKPLSKTEAHQLAPCSTESILDDSHECINPSFFPRLKFPPLVINNNSPIIGISSNNCLRTCFHIQEVINEAERFMRLNTAPVIELFARTVYSYREPRTTRQKFNFSDLWHAKPPFLDGILLNFKATKMIEKESRLFTETYSKPYLARILATPKRVIVEDIMSQDTTSTASSWSLHIISIRKTDFEEINSTRRILKTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXM1</accession>
    <name>A0A0B1NXM1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial dna protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003703">
        <property type="protein sequence ID" value="KHJ30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXM1"/>
    <dbReference type="HOGENOM" id="CLU_113779_0_0_1"/>
    <dbReference type="OMA" id="FWLWIFI"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19841" checksum="8400D45E519EDBA6" modified="2015-03-04" version="1">MALISASTIISSLSLFHITLGFFFLTSPITIADQTLVFIIGEAMKLPYKRSFENQSPPLAFLAAVLFLLGISDLASISKVDELTQLHWGAQAPIRLLIFFILTFYAFMFSKSSPIYATTSYVPSSWGEGLKNRVFFTWAFIEMIAWFWVYVTLREERKELSLRKQQKKSAEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXY0</accession>
    <name>A0A0B1NXY0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">EV44_g5164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003613">
        <property type="protein sequence ID" value="KHJ30793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXY0"/>
    <dbReference type="STRING" id="52586.A0A0B1NXY0"/>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="213"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="32754" checksum="2B75F70872E4CF20" modified="2015-03-04" version="1">MSKQSVRADWADDEDLSVDRIEEQLPPTTTTTNKDGSQTIVSYRIDEDGKKIKYTRRIRFTTHKEIVNPRVAERKQWSKFGLSAKDQPGPDSSTTSIGENITFRPSANWKKDAKDEKTEAGIMKDKLKDKKVKCRICNGEHFTARCPFKDTMAPIGEENSGDALTSINETTEGPSEVGTGKASYVPPHLRTGGAAGGGDRMGGGKYDRDRDDATLRVTNVSEMAEEQELRDMFERFGRVTRVFLAKDRETGMAKGFAFISFQERSDATKACEKMDGYGFKHLILRVEFAKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY18</accession>
    <name>A0A0B1NY18_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="6">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01003541">
        <property type="protein sequence ID" value="KHJ30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY18"/>
    <dbReference type="STRING" id="52586.A0A0B1NY18"/>
    <dbReference type="HOGENOM" id="CLU_031730_3_0_1"/>
    <dbReference type="OMA" id="ANWCGKP"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF32">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059225" description="AA9 family lytic polysaccharide monooxygenase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="8">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="379" mass="41137" checksum="AC8717D64D148420" modified="2015-03-04" version="1">MTHLTGLLFVLAGALTYSTNAHSLFTNLHVNNVDQGDGTCIRTPKNPSTATYPVTDLQDNSMVCGYDGTTPVNRVCSVPKASQLGFEYRLIPDDSSAGSVEPSHKGPCSVYMKAVTSPSEISGEGEGWFKIWDEGFDTNAGKWCSDKIIENNGIMNINLPPDLAGGNYLVRSELLALQEADKSPPQPQFYIGCAQIFLDSDEKSAPRADTTVSIPGHVQITDPSVHFNIYLPKWPYSMPGPSSYKSGVPTAQSISSKDHVQGLLPPKTVAVNGNWWGTEQEAYDSESGCWNATSNCYNQLKTCYDSATATGSKGCRAYEKKCSTMQSGCKSGNYNGPPNQGQILTAGVRGNIKSIDYMENTMSAAGLKVRRHWNRKQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY88</accession>
    <name>A0A0B1NY88_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005696">
        <property type="protein sequence ID" value="KHJ30005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY88"/>
    <dbReference type="STRING" id="52586.A0A0B1NY88"/>
    <dbReference type="HOGENOM" id="CLU_372633_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="746" mass="83755" checksum="DA8C24323C4B0BDD" modified="2015-03-04" version="1">MTSYPISSKSATTPNTSSRSQTTAPVLDFRCLFTRDVQRKQKRWQDGRLKFHTFNKRIMVHDERSNFVGDSYLSSGHKLEEGEELSLEQNGILVQVGEYMGKRDQDLDELVDKRLRIREERAIAKLNSGSLSSSNLAAEWKSSEPIQRRSNSLDVVYPVGQIKNKTISEKLALERQKIPRNSFMNELNGCELPTKRQKRNLSPPKKSTYAQNLMGARVFLTTKNTLSSTLKSQNLLQTSSVMQKSSRITIDLTKDDKNSSFKENNYNKNKDTSNPKYNHHYLAQNLAPPIHESSNEHASRVTRKKSTIPNRNDLSQKNMESHSILAKKDPSIRNLKLNIHSSISAKKKSIFQKEAPKISNPILAAPYNDFETPSEIQLRAVTQKSNSQSDKSLSPTVSEVTINLENSEIECNSASSVDNYPTKYVKNKTKNMLRLKSRPPRKLMFMESPLDGTIARDQAEQNRHGKLEARIKKKKLEAKVSSCITPSDEVLSTSDSSTLTQENQTKSLDLYHSNVIYDHTGEIESGVYPTSKDSCRLISKTKAFHKSRFSSKNVKSTADRTPVSEKLPDLNHKILRLEQNHEIGKPKYFKSDVPQTVKTGVKSHEQILQGVGKFSLNKEPQSTKLSCIDEALKLDYFVPEDDTSCQIDTLIAPITSNSEATKSLPKTLLSNPATRGIPLHAITASTIDALNIVGDLISPSSRSLSRVEESFSSNNTSNSLKLESSSTIFGPWSRESFDLFGITKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYJ8</accession>
    <name>A0A0B1NYJ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003304">
        <property type="protein sequence ID" value="KHJ31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYJ8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYJ8"/>
    <dbReference type="HOGENOM" id="CLU_169286_3_0_1"/>
    <dbReference type="OMA" id="PYNANCE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="80" mass="9281" checksum="8654279F333BAB7B" modified="2015-03-04" version="1">MHPHLHTKHNGACEELMNALDECHAKGFLWKVVGMCNDDKNALNRCLREQRNLRTKANREAAKIKNKKIREQWADIDANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ63</accession>
    <name>A0A0B1NZ63_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative leucine rich repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002651">
        <property type="protein sequence ID" value="KHJ31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ63"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ63"/>
    <dbReference type="HOGENOM" id="CLU_009538_0_0_1"/>
    <dbReference type="OMA" id="RQDFGNT"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="621" mass="69234" checksum="5ACC94C4BE37C822" modified="2015-03-04" version="1">MMDTEDGQFFIKNLAQFVRTHEKALANALQLKRQQSIKIAPSSSISGNKCASPASPTIPSTATSSTTSSTLAAALSLPHMTFASENIKAAKLALTQHHLFYLLSRFEDLGIAVGPMNIRLENLQAETSSINYVSFLNQHQRPKSGRASDHGSIHSVSSARSVFSGMSSLFANLSIGSSGNSTRTEKQKAALEADLKYLYASFTKIPCLRLAPDRHARLIQGYEEFPFDTAVPLHAFKNVSALEISDIDIRQFFGWDKLAEQLRSLIIKRAGVDDPEDLLINIVLDDMDRRRRRSTRLQSYPSVMESPKRSPTMSNSEMIDSNSEPGSPIERPHVETSTRPSRESLTQSGSISSIHSIKGRSRRFSPVRPSSSRNGPHYRKETCIVRRSGSGSSQSSMCENWQNSRNYHCTTPSLNYLPSSKWRFLKHLSLSDNGITSITASSLVPLSNTLHSLDLSYNHLVEIPDCLASLTALRALNLSYCMIRTLHTLIENPLPAITALNLRSNRLISLAGIERLSPLERLDIRDNFLKDPMELSRLTGIPEIHEIWVSGNPFTKTHGHNYRVTIFNLFRNTPGYKDDIIIDTHPPGYSERRQLADRAKEKSTMPGLKLPSDYSLKSIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZI5</accession>
    <name>A0A0B1NZI5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ppe family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005807">
        <property type="protein sequence ID" value="KHJ29999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZI5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZI5"/>
    <dbReference type="HOGENOM" id="CLU_099565_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ29999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="21983" checksum="6DB9D4E5C197C2BF" modified="2015-03-04" version="1">MTSMTDQSAIKDAAQRAFDAESDEDNQRQILAAAAGSAGDSANGKIMKFTPTVLNGLNAIVMDPSPDSVQMNTKMMEDPRNANILPSITQLSNAALDAMGLDMTAPKLRSTDGANGSDIANVTDLGTGSDNNGNNNNNNNNNNNNNNGNNNNNNSSNGNNKNNNNNNNNNNGNNNNNNGNNNNNNDNNGNNNNNGNNGNNGNNSNNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX2</accession>
    <name>A0A0B1NZX2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002484">
        <property type="protein sequence ID" value="KHJ31917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX2"/>
    <dbReference type="HOGENOM" id="CLU_2833068_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="66" mass="6822" checksum="2DDCC226B58AEBA1" modified="2015-03-04" version="1">MDTIGASGGGYDIYQGSNLLYTGLAPLGSSAEAHDADLAVAVSGVKAALETVDASFFRKHPRVPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P076</accession>
    <name>A0A0B1P076_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ras gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004713">
        <property type="protein sequence ID" value="KHJ30229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P076"/>
    <dbReference type="STRING" id="52586.A0A0B1P076"/>
    <dbReference type="HOGENOM" id="CLU_507343_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="240"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="537" mass="61758" checksum="173FF2D493A781B2" modified="2015-03-04" version="1">MNDTLKPQHLHPLRQTHNLNYSTMKTHKSSRSSIQSSVFSNSASGLDRPHTSIHSPNSSYDSSRRDSISETRDLSATSCNGMKHSAHSPLQNKTPFISDDMKIHYSRVPKHSRTNLNLYKCESSILSRANSICHESNLLHNKPKHHLQSPIRASDLHSFQKSTTSQLRTLSKFAKDITSEDFNVVSPTQQVAGLYGRRKLQRSGTAKDNSTLPSNRRLYEWKTRNWMDNQRQFLQAYEYLCHIGEAKEWIEKVLQRPIPPIVQLEETLRDGVTLAEIVAALKPEKTIRIFRHPKLQYRHSDNIATFFRFLADVELPDPFRFELTDLYEKKNIPKVIHCIHALSWLLYRNKIVDFPIGNLLGQLKFEHHELEEMQRGLEKAGVSMPSFKNMGTVFGPTSGPKSAFEQVKSEQDLIRSKLEKKLPLIIYLQAQAEGAMNRLQLGEMMHQLSDSEKPLIHLQSMIRGAFARQVINYRINMRRFATSLQSIARGFLTRQRRAGQIFLGKEDEEKLINLQNLIRAKSVRSKIDRVSTASGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L4</accession>
    <name>A0A0B1P0L4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative wd domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003613">
        <property type="protein sequence ID" value="KHJ30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0L4"/>
    <dbReference type="HOGENOM" id="CLU_012621_1_1_1"/>
    <dbReference type="OMA" id="CCFTVAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="687" mass="78382" checksum="1A92CED41CFF4308" modified="2015-03-04" version="1">MAIKASDESAYHTTTDLILPKPLKFYCAPMHSGHWQLRSLISSPRPDILFYPHGRDIVVLNTKTRERYILTTLKFEPRCLTSTNEWLCCGGDKGDYTAIYFGHDLRSISCHSQDIDLYARLPFDLDPFWRSAPAQRPNKDIRPITEVTKLVGIDIVNCITIWTPSDISSECAYKEPVALVSNNDRSITILKLESAEILEKLTLPDCVNRSLMSPEGDMLISICDDPFLYIHKRKLINKYGDELRFSKKSKYNWHFEGRVQLEGQVRTNPPESRGSFAAAFSPSAKYLAVATQHGLISIFEKNNIFAPPVSVFTSSRMTSNGDGYVRDMEFCPGPFDLLAWTESKDRIVIADVRNFFLSRQILLLDPNQIEDVEKISINDRAVNSSVDSSRLRDEPTFRVITDYSSLNSESSGRRPIRTLSRDELNRRAQLRILDQPLSIQRRDGSTTRMETSTTPTWRSSIEVRRPISISYTTSSLRSGRPSNAGLPTTLREFLTQDRAPSFRSFINDRNRVHERRSQQDHEQDLEPRRRTIAQNLASSLNTAESFTDREVPRNESENNVNLERLSLSNAQRRDLESDSLWSGSSLSQLRNSSHPQSSDRTSRLRIELEEDDRGEIETRMDELIDFALDAQRVITGQRISPQNGIVTTMGCCWSQDGKIIYAATESGIHEFHVNIKGRKLFPRLTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0W2</accession>
    <name>A0A0B1P0W2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002213">
        <property type="protein sequence ID" value="KHJ32272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0W2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0W2"/>
    <dbReference type="HOGENOM" id="CLU_014033_2_0_1"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="580" mass="63588" checksum="F237D4B3534C0053" modified="2015-03-04" version="1">MDSDEIIHIEGPEISSNDPLRDFFPQSFGTKSKEADIATQIERTRRIVKKVDPISNLNCVKEEDEDTDNSDCSDDVDEFPVSHELVLKIHERAVTTVGLDPAGGRLISGSTDCSLKFHDFASMTPTTLRAFKSVDPSQSNTSKNSETHPIHHVEFNPMSGSTFLCISAHPQAKIISRDGEILAEFQKGDMYLRDMNNTKGHISEVTHGTWNPVNKNLCVTAGTDSTLRIWDVNYKRCQKEVIVYKSKAAGSGGRSRMSAVVWGNSSQGGKNVLVSAVVDGSLVMWSGDGPFNRPAAEIRNAHEPGTWIGGIDMSIDGRMVVTRGGDNLIKLWDTRKFKSPIVTVSHPSTSDHYSMTNIKYSPNSSYIITGSATGDLFILNPGNLKPELVTTVTPGSPLITVAWHPKINQIITGSANSEVHVLYSPDISVRGAVDVVSRAPKKRHVDDDPNFTTDQSIGISADSILTPGGSISNISAASYSARHPNTGLTASGRSRDPRRPQIPIVTPFMKSQPDEEHVNQNIPLSSMRDEDPREALLKYAKLAESDPIFTNAWKNTQPITQYANLSDDEDDEPDPKKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z5</accession>
    <name>A0A0B1P0Z5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative spermine spermidine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003398">
        <property type="protein sequence ID" value="KHJ30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z5"/>
    <dbReference type="HOGENOM" id="CLU_017511_2_0_1"/>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF59">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="590" mass="66303" checksum="FE844CBFC1B38448" modified="2015-03-04" version="1">MAQQRKSKFSESSGKEAPTDILFTKENFEKELKNLAAKAQEETWLRWAASQAWILIQVCILYNLAAASSTVSLLNLSPVYGSIPSKIWHSQITWVSCFLGWSFNRFFQRLIPVKVRHILPLIAAYIPLVQFSLFKLSDLLGAKLGPTVTELLTYSPLLIFTTSVAASLLSNLDLELRWIPLWISESLPGILSFLFFKTIEAFTEKKIQNSIGSSFLQTRLGLQVVLTGLYGIIGPSKLLMFILPAIFHTSLLNIHAPASYTTNMLNSSLASKGWLLLERRDSITGYISVIESREQNFRAMRCDHSILGGEWLLNNRFQRVAEPIYGVFVMLEAIRLVELKDPILDSEATAYVVGLGIGTTPSALIEHGINTTIVEIDPVVYDFAQKYFSLPSNHQSIIADAVSYTAELVQKGQKYDYIVHDVFTGGAEPLELFTVEFIQDLSAILKPGGVIAINYAGDLSIPVARIVIKTIRSIFPTCRIFRETEKSSASLVANGDGHDFTNMVIFCTNAANEIIFREPINNDYLGSAAREQFLLPKHEVDESIFAEQETDGDLLKMNDTERFQDWQRKNSLGHWSLMRTVLPPIVWEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z6</accession>
    <name>A0A0B1P0Z6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g3179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003921">
        <property type="protein sequence ID" value="KHJ30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Z6"/>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="455" mass="49989" checksum="356D795BB1A2D27D" modified="2015-03-04" version="1">MRSSLFPIPQLPSATFPSWGRQFLSITLDVKIRMMAAFWIFGLINNVSYVIILSAALDLVGPLIPKGLVLVVDVFPSFLVKSIAPYFLIHKVSYPIRIIIMCVLSAGGLLTIALSQQNQIILKLSGVVFASISSGLGEMSLLGLTHFYGPSSLAAWGSGTGAAGIVGAGLYLLLTSILRLSVRSSLLSSATLPFIMPLAFFCVLPQGPLNRKSQMDYAPLLHAPILDEDGTGSHCSDETPHSMPITDNSTNSHSNIVSSHGHNTVPNELSTKIRYLRSLFLPYMLPLLLVYIAEYTINQGITPTLLFPLDKTPFSSYRSFYPTYAFLYQTGVFISRSSLPFFTLNSLYIPSLLQVLNLVLLTMQALYFFLPFVEIIFVITFWEGLLGGAVYVNTFAAIMRNRNGEEREWSLAATTVSDSAGILIAGIIGIFIEPQLCEWNIRYKRPWCQEAGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P160</accession>
    <name>A0A0B1P160_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative arid bright domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002439">
        <property type="protein sequence ID" value="KHJ31968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P160"/>
    <dbReference type="STRING" id="52586.A0A0B1P160"/>
    <dbReference type="HOGENOM" id="CLU_008900_0_0_1"/>
    <dbReference type="OMA" id="NPIVCGR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="426"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127407" checksum="40098CFA8CB8B1CF" modified="2015-03-04" version="1">MSSPWVNKSVIQNQNGPAYASNDLETSGYNNSAPFDSFESSQIQNQQLQRMQNGNLRNGSPVSFSNSQYQTNSLVPSKRPREEGMRTSPQQTPGLLPLSRSRTPQQTTYSSFQSGTQSQQHSIQQIPFSHLQDGSGNATPSPVMGNQIRPSGIGVPQRVSTASPHPFSPAVQQFPQASPSFSDQSSNRLDGSQQSNQYAQNSGYIHNFGTSYSPPLGHSSTTLQLPKTTPFMRQSLIPQGPMPQLYQQPQPQQQQSAAAAPQQQPQQQKQPQSQTQQNQPPSQPQPQPQPQPQPQQQQQQQQQQQPHQQQQQPHQQPQQQPHQHQQPQQQPQQHQLPQPKQLQHQQQQQQSQSQQQPQGHQQQQQQQQQRLLYQMQLQQQQQRNIISQCNSITPSTTPINSQQIQAKNGNFQGSRSSLPYPINRASPNPENFMKSLVSFMQAKKLPLEIKPIIGNRAVSLASLYSTVAKFGGYKAVEAIKGWGDVASALQFHSIEQRLAPLLLKGIYERNLFLFEEAITINQHNQRTQLMQPNSNLSVPQISPTKQQNSQSVPLNHQKTSYLSQQIPISTQPQDTQIPVVATPVKQVQPLTHQQVTPSNGYSTPQQTQMQLNSLTSHTYSQDSISKNLETTPPQNNLFPTPSPASVSVSVTGSRGLALNSPQIDSQDIRVSLSHKFNLPSVYEPKTFVLDTFGGVNIPSLARLGGELTRLKIDVPAVGDLGTIDVHALTMSLQSGIHAEMRLALDTLVCLSVEPRLQLDLHSCEDLIDTLIDCAELQVELLVENAIEVSDVMLVGSYEDVIRGCRLEQDFLQDLPVLGSLEYKLDRAVDRLICITTILRNLSFYEANHPLLADELIIKFLCVVIRHLGTRNMLLRTHSNTLDFMKDIVVFLSNLAQQIELPGREQALCLLHFLLAFAPCPTPNSSSLETVIFSSYNPNVHRYLPPAVDSLAKLLARDEPNRSLYKVIFTSDVASIPPYDLLTRAFALAISCLPDNGQDLQRSNILPIIEARKPFLMQGILAAGIISSLVPSYETGVAKSWLTSEDGFSQNLCRLIITLSIETSSLALRQPMTPLGIDNESTFHIILGGTTVLRRLVEKSRNSEDSNSKYSPPGVLAKDSLLIAINIVQPRLQDVLKQLYEYVGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W3</accession>
    <name>A0A0B1P1W3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative spc97 spc98 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003495">
        <property type="protein sequence ID" value="KHJ30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1W3"/>
    <dbReference type="HOGENOM" id="CLU_003736_0_0_1"/>
    <dbReference type="OMA" id="TIFTHLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000923">
        <property type="term" value="C:equatorial microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061496">
        <property type="term" value="C:half bridge of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061497">
        <property type="term" value="C:inner plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="223"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="530"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="908" mass="102886" checksum="E1BBCDE6F2F0AD27" modified="2015-03-04" version="1">MSSRSQRINNGVNSLVGKFLADKPLPDGISKEERVIDTINFVKGTLENWKTPSVVSDVNHASDLIKMQLLQANPTPDQALRYLKLYSTLISIPVIKEKWAVLYFLYQLKNLPNRSSSPIVLKSPIKSPIKSPTKNVQNRISSNYDIHNGAERDSIKVDKNLSEAFQSDGLRRLPAREGGQRDKTEDQKMFLKSAAAQRQGVSLKTSLLSENYFEINPPETVLLRDISFILQGLNSTNFTFVESRLKLPKTLPVPILSVLHTLAEPSLLYRSLVSFIQSSSAGLIGQSLRAALSTELRSYLGLVAVLEGQIRSALFSIDEKEPRGGIGKVGVTLKRLVVWTREATMGLRLMSIISEESKNKRGGQLISLIHGFSSAHGDPTVGAFAERLLTQVSRPFYDMLRHWIYDGELSDPYHESFVSEKDLHAVENQESRNRGGGGASNVWGDKYKLNDDMVPSIITSDFAQKVFLIGKSLNFIRFGCGDAQWVERYSKAASKELRYGDTATLETWIDEAYKTTMARLIHLMAEKFQLFEHLKALKNYILLGQGDFIALLMESLSSNLDRPAGAQYRHTLTAQLEHAIRGSNAQYDSPEVLRRLDARMLQLSHGDIGWDCFTLEYKVDAPVDVIVTEWGNRQYLKVFNFLWRIKRVEFALSSTWRKCMTGSRGVLHGEVKSVIQTWKLTRGVLAEMIHFIGQLQYYILFEVIESSWDELYAEIHKDGCTLDDLIKAHTKYLNAITHKGLIGAKRKYYDDTDDNTFMTQLGEILRLMLSYRDAVDGLYSWSVSDYIRRQGADVQRELFSQREEDDVLLTPSITTHRMTGKFSDVSPLSPTEYPISDEFPALQERLNSLRNHFKSRVCLLVGELAHQPDVDMRFLGVAMNFNDFYQPMRKKSIRTASKDNTGKNPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P215</accession>
    <name>A0A0B1P215_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002978">
        <property type="protein sequence ID" value="KHJ31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P215"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="39203" checksum="501675E408DE0485" modified="2015-03-04" version="1">MAPPVFNKRGPPPDPPDAGNRVSKTTSALNRKSGVTIWINVRSTSSLTSGTSITKPRSTPNANVALHKSSILEKNFGAEQFSIDDQADKADMDVEPEELSINTINSDPFEEDFPPLSGISNANVAKSTTESSKINEENRSATLLLDAIKGLLDLTNLYLKKLEEEHPGIGTDFMALLADGASRAMRGERVYTNLSNISSSNPKVSKPSWAEKAGAAVHGQNISLKKQTIRASPPRGQSKEDRRVIIRLGPDHEARKTGSFELRQKIQQLIPDKSLIADVWTVPSGVAIIAATPAKAATLLQYKEAIENRFGDAIVERQETWTTYVVGPIPKKIRGLDGFYDPFDGLLQEELAPIRDAVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A3</accession>
    <name>A0A0B1P2A3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003284">
        <property type="protein sequence ID" value="KHJ31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2A3"/>
    <dbReference type="HOGENOM" id="CLU_883381_0_0_1"/>
    <dbReference type="OMA" id="RETCTID"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="36061" checksum="5AAD27C0D9777BB3" modified="2015-03-04" version="1">MVERYHYPVRRAYNIIREDLPHLSKRACLKMAFKAINDTAGSKGLVPTLLVFGAYSRISNLDAPAVSVEQRAKAYEKAMENVRKLRAERQVKDALSMRSGPITSTIRDLPLQSQVLVWREGGIGKKGSWQGPYNLLGIDGNTCIIQMQQNNDKPSLFRITSVKPYYQSAQIETSDEDRALHESKDPIQSTSQEEKIYQPTRTQPKRSAGRPNRYAIYCQNEPVYETFISNYLPRDGFKTSRKIEFRGLVDRMVTSFVNKDQIPPGTHVYKAKFIDSIKNKESEDWFEKSRLCIAAWGDEDKWTVLTQSPTIQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A6</accession>
    <name>A0A0B1P2A6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003275">
        <property type="protein sequence ID" value="KHJ31081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2A6"/>
    <dbReference type="HOGENOM" id="CLU_001442_1_2_1"/>
    <dbReference type="OMA" id="HRICGEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="7">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="274"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="524"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119643" checksum="0661312D6FCE4677" modified="2015-03-04" version="1">MSGSLPSGLHSPPESNFQKYCESDSELSDVEEKMKSTIESHIKIKPSNFRDGVPVFTPTMDQFYDFEKFISAVNPWGMTHGIAKIIPPKEWLDEQPTLHEEVKKIKIRNPYIQEMNNQGSRGASGNFRQLNLSSNRTYNIVEWRALCDQLSRQPPARRGETRKAPEKIAHLSKKRIEPDRSIENCEPQTTGRISKISTGKKSKLKEEEVSVNSRRNKYKEDNNIVDEEVFRDFDYNLYEEFDDERCQDLEVAYWKHISYAPPIYGGDMPGTLFTDKTKVWDLRNLPGFLNYLDEKVPGINTTYLYIGSWKSTFSWHLEDVDLYSINYLHFGAPKQWYSISQGDRERFEKAMAMKWPDEYKHCNQFLRHKTFQISPAALWKEFKIKVNKIVHRPGEFMITFPYGYHAGYNLGYNCAEAVNFAVDEWIPIAEKAKRCDCAQQQDSVWVDLNSIRRKLPRTHKWYLGDPDEDFFAESECERNTLDIPTPPHSGSEVKLPVTRKRKIHTKKIEDRHVKRRVPIRSSEEPPCILCPNFDFEVLKTDNGKHAHRICGEYIPETSVSNGIVQDINFISKARMGLKCIYCRSKRGACFQCSSAKCTRAYHGTCAAASGVLVQKVWSSRFAQDGTEYKEEVYDFRCRFHRPRRDKKLDEAAISMDRRILEFGSCLKPGEICQIQLLNSDIFAGTVVTNNRSEDMVVIKVLFDHTDTLYEIEYKWLLAPPLESSLPKPSANAIPMPVSFKAKESLNTCIRQVNDLPRPRDKFVESFTWAEFVTIAITNNPDQVKVDLTKDSQIWYYIGKTSTEAKAHYTDDLKKPWDNSKGHFLSTVPKSTSALFRHSNKFSNSSDRSGILGPLQRSITTVPKTPLIKGLTQQVSRENPKKILFNPTPDMKNITHDTPYQRPTIYTYGAETQSKTGSPIKNKSRKKALNNSTYTRNISNLPSPLTPISHKKQPSLVLTQPNWPPLSPEKSIVSNFHRRSILTPSPCQQVVGSKEQVTNHILSSPSIIHKTILPNVPPDTSTLIERMMNNLKKACSDTNNKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2B6</accession>
    <name>A0A0B1P2B6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative rad4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001810">
        <property type="protein sequence ID" value="KHJ32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2B6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2B6"/>
    <dbReference type="HOGENOM" id="CLU_003639_0_2_1"/>
    <dbReference type="OMA" id="TWPGKTK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="617"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="676"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="746"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118170" checksum="D47C2D0627298EEF" modified="2015-03-04" version="1">MPPFSTRKRAGAHDEESTSQHQKKKVARNIESNIPRNIRRPTLSDDLDSGLWNKQRSEKATLNNLTVESDDSVSSLSTSEEFEEVQIDKIHAADTSETEDKNVEFENIQSSINALASSSLQTGDLELTLTKDSRISITNPHGTRKGPSKIERQIRISTHKCHVQSLLFHNAIRNSWLCDKELHALLLQGLPKSLVQLIEKWKRNSGISSKEAIEKKQNEGKITSKGRNQKDWGQASKSVADDQVNMSAGDPLFHLLRALALYWQQNFKINVPGLRKIGYMSLQRLDDELKSFSKDEHDPMVHGERFQDLEDFKSRAKAMQGSRDFGAQLFTALLRAIGLNSRMVTSLQPVGFGWNQTEDAHDKNLQPKKKGNNKTDEENIDLSPQKNSDNIGSTGISKKKGRVKMSQVSKIPKKTQKRASVNNSDNLASNSESELSFSSSDNDFSDDGSLVGAVDNQKSASLSNYDRDLKYPHYWSEVLSPVTKKYIPIDPLITQIIATNRELIEKFEPRSTKSGKLKQVIAYVIGYSSDGTAKDVTTRYLKGKMWPGKTKTYRYPPEKLAIKDPNGKVKRYIQNDWFKNLMYFYERGGEKYPRDAIDDFEEATDLMPARRERKEVEAGKETLQYYKTSSEYVLERHLKREEALVPGAKLVKYFTSGKSSNNFKEGVFLRKDVVICKSVETWHKEGRAPKPGEQPLKHVPYRAATTHRRRKLAEAEEATGEKMLQGLFSHSQTEWIIPAPIKDGIIPKNEFGNIDLYVESMLPKGAVHIPLRGIPKICRRLGFDFAEAVTGFEFGNRIAVPIITGVVVAAEHNDVIIGEWHNEEAERVRKEDQKRKQTVLQMWRKLLMSQRVIKRMKEEYDDENIDVLNPFTNKKGFSIIENGITSENIIMDRRGEDLAGGFLPEGIDAESEPYHTSGFFPVVDQDENATDYLCTDNIILHGYDNDENVKKKGSEEHAQLCDGESDIKIQAQSKPTKNSARSSKKTNLSGCNKVSRPVDIKKFSLKQPRRNAARKCTQALKSHYFKHEQSNIEEESELKSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2E0</accession>
    <name>A0A0B1P2E0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative signal sequence receptor alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001789">
        <property type="protein sequence ID" value="KHJ32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2E0"/>
    <dbReference type="HOGENOM" id="CLU_068820_0_0_1"/>
    <dbReference type="OMA" id="YQEEWIP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079668" evidence="11">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="30706" checksum="B6376295ED519942" modified="2015-03-04" version="1">MGFSKLAAPLLLLICMSRSIYAVDPTEEKLSSTPNLAVSVIASFPSSTDEFGLKIFNGHKTKAVLQFTNSEAEPIIVSSVNGILSSLKSSPTDLLPTVNLTSARFNVAIKSSEKQSLSYTFTTDLHPQNLRLDIIATISNQNGSSYHIQAFNQTVTIVDPPASIFDPQIIFLYLFLTAMTGGSLFWAYSTWIKPLLPQAKRGARSGEYIKRSNKSDKASIPSKSQNNISEPNGTDDSGTLLENKMYDESWIPDHHIKKPTVKRLKGSNPKKYSKNENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2F2</accession>
    <name>A0A0B1P2F2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2F2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2F2"/>
    <dbReference type="HOGENOM" id="CLU_298798_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1005" mass="115406" checksum="684682149D8F3380" modified="2015-03-04" version="1">MAVIEDFLNIASIYTQSFKLSSKNYYGNMIGNSRKGLEIYEEFYIHNEQHLSSCVKDTALEIMPICEVASRYLSYLFAGNIDFEFPFTLTSGSMQRFLDHVTLSSHQNQYGNETWFQQPWSHTFYPMRLTLFVVQSAPSFIANEGAMNDTCSREIGIEQTICNTYLKSSPIFPLLVEVHLPSLNIQTLNRIISPFNSLPLSPIDCSWIIFINEKPTRRKEMTSWSISDISLFNKLSMINLYSSIPLSSYFIYRRLQLTPFDRFYCTEGFHSAYQIQSQSFISTQPLIMYNSSVGEENSLSQKSFQVTYALHNSPEANFSAGGSSKNEIRVGSMSLSHISLKSHRDIRDPKDERQITHDSLHGFSKNSKKFHDSHRTSYSTIDQIEMDLNANKIETSLQKLCRDSLKAYPFYEGIDYAPTKSEIISGENITSQINNKLKTNQNYGSPKLLKTLDNENLQQEAACSDIFSRIPHSKSISEAGFRSTGTSSKLESSKNQSLSNLLEKKILHGLNAHDTNLTPLGSVSLNQRKLIKDTKNNFFPEPNLNYRSDFQDCGDLRHDHFVHNPGSHKMNRTMSLSTPEYKNTKMFCLSYQYPSNLISQNNHSLQAPRSNSLTKQLKLRKCRPQLMKALPPIPSKEYNVIGKNSMAENKDFDHDRSPHSSPWHTGSETSSLKMDSGESFKLKFFQTLRPLTQTNHIKADNKTTQNFKKYDDNNYDNTRSPPKLRLKARKFQNSSPCPSISRILDSMPWNDNTKVTNIPDTNKILDLDKYTTIKSSGLRVKHSQNRNPSSQTVHIKRAPISSKAGINLPHSNSKDLFTIHKNSDDIIREPTHDLQLRKSILDSDNLITNLSVSNIKVNERKRIKRGFLTWQKRRVGPQDSTEYFRSKIGITNDEPKIKFNEEVRKSDEIHYRGIRMHSTLRRYPSKDGARGKISIHSEPKNLKTPRSTPNFHQKYFESVPCLREEPQGQILKVKIRDWIKSAKSAISNRIESHAKVWRKKHEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2L2</accession>
    <name>A0A0B1P2L2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003179">
        <property type="protein sequence ID" value="KHJ31166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2L2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2L2"/>
    <dbReference type="HOGENOM" id="CLU_020435_2_0_1"/>
    <dbReference type="OMA" id="GHRLNAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14309">
        <property type="entry name" value="UBA_scDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="456" mass="49404" checksum="45B8AC08F69D30AF" modified="2015-03-04" version="1">MHVCLYVARLDAIPIGFLLSAGGAGARITINITGRANVENDLLSLEISPNTTVSMLKASVYGETQISDTLQNLYHNGQLLNDETKTMQQLQIEDGELLAIHVLDTTSGQQENRNVQSSSLHQNRGRSQEIPDPETIRLHLLGNPAARAQALHHRPELANVLDSPVRFLSMMRQINAQERSEQNRRQQQIDALNADPFNHEAQAKIEEIIREERVQENLQNALEYNPEVFGHVHMLYINVEVNGFKVKAFVDSGAQATIMSPSCAESCGIMRLVDKRFAGVARGVGTAAIIGKVHSAQIKIGSLHLPCSFTVMEGKDVDLLLGLDMLKRHQACIDLSQNMLIIQGNKVPFLGEADIPKNLEIIRGQEPKVPGPGGTMIGSKSGAVTRLPAVSQPESSSGLTSSLTALPEVPGAQQNASHSEGVEQLMALGFSRKEALQALEVSGGNVEIAAGLLFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2P1</accession>
    <name>A0A0B1P2P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002747">
        <property type="protein sequence ID" value="KHJ31600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2P1"/>
    <dbReference type="HOGENOM" id="CLU_1961204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="128" mass="14509" checksum="41717F1DBC772DCB" modified="2015-03-04" version="1">MKNKIEIENRFGKHVVERQEMLIDPLDGSFLEELGNIRDNMPIRYIGWTRRSLQDDSNSFARICVPGNKASKSKVQLHVTNAMDFIQLQLQNIRAAGGREYLKAQNENMEFDVNLAGLASTESVSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Q0</accession>
    <name>A0A0B1P2Q0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003139">
        <property type="protein sequence ID" value="KHJ31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Q0"/>
    <dbReference type="HOGENOM" id="CLU_2185915_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="109" mass="12067" checksum="692FAA9988914252" modified="2015-03-04" version="1">MIFRVKSTYEAMQYPISVAGVGQVIAAGHGDLLLSTCHGKMEKLTGAILTPGQKIRILSTSQIENQGFSIRLPIKFQHKEKIRPDGSPCARFKRVLNKSIYGLKTAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P352</accession>
    <name>A0A0B1P352_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative zinc finger protein rts2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002619">
        <property type="protein sequence ID" value="KHJ31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P352"/>
    <dbReference type="STRING" id="52586.A0A0B1P352"/>
    <dbReference type="HOGENOM" id="CLU_030065_0_1_1"/>
    <dbReference type="OMA" id="QVCERQM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="301" mass="35116" checksum="EAC272541333C97D" modified="2015-03-04" version="1">MPKAEAGSTKYLNNKLKSKGLQRLRWYCQVCERQMRDENGFKMHTQSESHYRQMLLIGENPKKFITDYSNQFHRDFIQLLRTSHGEKLVHMNHFYQEYIHNKEHIHMNATRWLSLTEYAKYLGRESICRVEENEKGLHIAWIDNSPEKLRRQDAIRKKERMEKGNEERELMLIRQQVKKAQLDVKRKAEEQLDETERELKRTEGEKIKLSFGLKSAQPKDNTQSSLVEQNDIEAGNYKKPPDETGPMISGVLNQSSTKMALSNKPKNVFAVGKKNVFGIKKTSKSSKFAGKSQDDPSKQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3B1</accession>
    <name>A0A0B1P3B1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0459</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001585">
        <property type="protein sequence ID" value="KHJ33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3B1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3B1"/>
    <dbReference type="HOGENOM" id="CLU_090411_2_0_1"/>
    <dbReference type="OMA" id="DMIAYDG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00985">
        <property type="entry name" value="3a0801s04tom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="18614" checksum="D19FD9CE2EC2CD35" modified="2015-03-04" version="1">MVQPSTVVAITLSTAATGLLTYAVYFDYRRRNDPEFRRQLRRNTKRQARAAKEEAESQIVRQRQDIEAAVKMAKAEGFPTDVGEKESYFMQQVARGEGLGISGNENIEAALCFYKALKVYPTPSDLISIYDRTVPKAVLDILAEMIAADSSLNVASFGLGSDIERGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I0</accession>
    <name>A0A0B1P3I0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nadh-ubiquinone oxidoreductase 14 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001805">
        <property type="protein sequence ID" value="KHJ32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3I0"/>
    <dbReference type="HOGENOM" id="CLU_164170_0_0_1"/>
    <dbReference type="OMA" id="IAVRFWQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="92" mass="10673" checksum="C069C7DAB08B5926" modified="2015-03-04" version="1">MVHNAIFWGGFGLAVRFWQLGLEMRPLISKNNLWAYPLFGGVGASFGWWLEGVGIRQKTMILERKKILLEKRARRDKKIQALSRLENDKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Z2</accession>
    <name>A0A0B1P3Z2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal homeostatis protein bsd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002953">
        <property type="protein sequence ID" value="KHJ31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Z2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Z2"/>
    <dbReference type="HOGENOM" id="CLU_041193_0_0_1"/>
    <dbReference type="OMA" id="SFVWNGM"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="37210" checksum="96C91406EF1A65AC" modified="2015-03-04" version="1">MSSQRYERISSNDDETEITTPTSPPPSFRSCASSVDPRIRAGSTVDTNLVEAFDANGSDSDDENNDDTRQRLIRNILPAAERQAPETTSLAGDQRPVATRIDTRFPSGAPLRTTGRVYGGGSGSDGVFANLSAKPESSEKLEEHPPTYEQAAADSAPPYWETTILAPGLGGPDEVYIEGLPVGSIFSFVWNGMISMSFQLVGFLLTYLLHTTHAAKNGSRAGLGITLVQYGFYMKGSGRSATNSPVDEISTQYEEPPDPNTHNFDPEKLNSPGIESGDSKSWNNVASSEWMAYILMIVGWFVLIRAICDYLKARRHEQLVLQSPERGLNVPIIASGEEAATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4B1</accession>
    <name>A0A0B1P4B1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002618">
        <property type="protein sequence ID" value="KHJ31746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4B1"/>
    <dbReference type="HOGENOM" id="CLU_1262350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="24640" checksum="B28EC067CD6F6319" modified="2015-03-04" version="1">MTSDGHAKVCRVGNCLVSALFVIKTTRAEWLNNWGDTRVFEASNEYALLPSLMSSLRAIAGIRSQQPTVALATSNPNERGLDPEAYYAAVEVAKSFKTAGYCWNFHSATRSPDLISKYGNINKNASNLMLKCHTSHTLKYLKKIKRLSVLPSFDPTKDTLALSQSRYAREPIERNGLKFYKPISTLLEKLIEPNKIEYTFGQKDEYNKFIGTQYVANNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E5</accession>
    <name>A0A0B1P4E5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sister chromatid cohesion and dna repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4E5"/>
    <dbReference type="HOGENOM" id="CLU_002562_0_0_1"/>
    <dbReference type="OMA" id="YPPAYNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1260"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1282" mass="144063" checksum="FD2A9C21FD0A7168" modified="2015-03-04" version="1">MAPRRSAAEQNNLKGLKFNKPLSWRAGKPIPTGELLERLETLSKELIDLSDEQEEVHKTSLSKVAKELAGQNLLGHRDKGVRAFTACCLVDILKICAPDAPFTPSQLKEIFTLFITSILPALSNPSHAYNQQHKYVLASLTEVKSIVLICDIPNSDSLVLHLFSNFFDMMSGSIGTLSSDQIPRDVEFNMTQALVILVDEAQSLPSGVVDVIVAQFLRASALGGRKANEKRKEDLDEKQSTLILKELPAAYNMAKTICNSCSEKMARYVSQYFNEVIMEISSGVPKLNGYGGVSDIPQDSDKDDSAPTEADMKELEKAHDLLRELWRASPPVLQNVIPQLEQELFADDVQLRLLATETLGDIICGIGAAGPPPPPLMDPAAYPPAKLETDYPPAISDSILTTPISPQSFAQTYPNVYQSFFSRKNDKSVVIRSSWTTAVGRILVTAAGGIGLSSNEEKSFVKSLAEKLNDSDEKVRLSAVKAVGGFSFRHIISILAPNGSVSTSGSVLGSLADRVRDRKHIVRVEAMKVLCRMWGVAIGEILHKNDRVVDALGMIPTKVFDVYYANDPELNVLLDQSIFEQLIPLTFPSSKTKLLRSMKKKNENSPFLENGPINTDKIRTQRILVMIDSLDAKSKKAFFAIQARQPLYANVLEAFLKCCEEFNGGMTDKNIKEVKAKLELPIKWFTKVLPDSIAIDQDLHKFAKLHDRRSYQLLRFAIDPRSDFITVYKAIKELTKRIQSNQTASSGLLNTLIPIIYRSACLIYNISNQMFFSQYARTNEHELSATANAIIQNISEKHPEIFQASLKELCKLIQANAPSNTKPNDVAIVETLKSLALFTKSNRNKIPNDKNFVDSLISFSMYGTPPKAAKYAIMILVATTDRKEMYIKDILDKSLENWEYGTDNSLTKLAVINQLTILAPGIVEESNSEILNISRQLLLEARTETIDSQLEWQVDSMVDPECQAKCYAIKILVSRLRSIETNEETAKALAIPVFRLLNTLIEKNGEISKRGNTPKHHKARLRLLAAQKVLKLCTSELFEKFLTSRDFYKLSYVAQDPLEDVRRGFVGKLQKFLAKNLLPNRFLTIIFITAFEPSEDFRASIMAWIRYRVKISQDSRKGIFEAIFPRLLHMLAHHPDYNSNPSELIDHARYILYYLSTVASQENLPLIYKYAQRVKQARDNFAGADSERLYVLSDLAQAIIKRWEEKKRWSMQSWPKQVGLPTGLFAGLSNHEVAQEIAEKTFISDELDPLLDSLVKEYEKKRKRKLDDPRNLQPSKKLCDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4G9</accession>
    <name>A0A0B1P4G9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002237">
        <property type="protein sequence ID" value="KHJ32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4G9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4G9"/>
    <dbReference type="HOGENOM" id="CLU_022996_1_1_1"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="374"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="528" mass="60015" checksum="313BE79546CE16CA" modified="2015-03-04" version="1">MMDVTLESTVHGPKTPNKSKALTKSVNNNFSKNERLKEAEKVYGRGRKVPLGDIRDKKLRRKLKVIEEKYKTATLQAKDAEILHENEAGLLEPENELERTYKVRQDEIQAEIAVETAKKKFELKLDVLGPYICDYTRNGRHLLLAGKKGHVATMDWRDGKLGCEIQLGETVRDAKWLHNNQLFAVAQKKYVYIYDAAGVELHCLKKHIEVTNMEFLPYHFLLATVGNPGCLRYQDISTGKIVIELPTRLGSPTSLTQNPQNAILHMGHHNGTVTLWSPNSTTPLAKILAHRGPVRAIGVDREGRYMVSGGQDLKMVVWDIRTFKEVSSYSTRQPASSIAISDRDLTAIGWGTQTSIWRGLFSKSASEQEKVRSPYMSWAGEGKHIERVKWCPFEDILGISHSHGFSSIIIPGAGEPNFDSYEINPQETTKQRQETEVRSLINKLQPEMISLNPNYIGNLDLTSHEQRQMEKDLDKPKNTLSVIKNRGRGKNSSLRKYLRKKGSKNVIDERRLRIEELRKKQSQKAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P520</accession>
    <name>A0A0B1P520_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002081">
        <property type="protein sequence ID" value="KHJ32435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P520"/>
    <dbReference type="HOGENOM" id="CLU_546252_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="57263" checksum="C363E6B9775588DB" modified="2015-03-04" version="1">MLRLPPTVIGLARSDIQDHDKRRQFSHCKDKHLLNKTLRNTVTTIPRHLTLAYRPLPKNAIDLLYSQRLSSNGLLHISEGNSLVPSLTQNSLQTCHSLENKVHFAVFTNQLSKNFLFAGENRLNLLQAIDKSNLQCHGPSISSSLHAYNIQTPEDIYLVNELRSRIVSRVVDNESSGLLFSQIPRAKERSTIVPRHQENSYLINSSGYIIEACERSRDSSSSASDLLFSSSNLIDINEESYSNYLQSPEHLTKTKLALQDPRNEKNYTQNSTFSACLNLPPPFSVKSRRVSAVESIPSTPQPIHLEGKFMSTNSHQNTNEPNQIEGNEISAKILDPQLITPGLSPNYSPQQKHLDDFEKIGEDQIYLKQKTPSEPYRVYNDEIPPELQPQTPANLPESRHRSRYHSSFTAPDFQFHRRNSPSDVFNGMDTLGPQQMTPVASYVPNVREISPAGLSLHNLASLYRGRRISIDSQNWIEDLRLDSSYVRLWRSDCTDHTASDDRVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P548</accession>
    <name>A0A0B1P548_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001458">
        <property type="protein sequence ID" value="KHJ33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P548"/>
    <dbReference type="STRING" id="52586.A0A0B1P548"/>
    <dbReference type="HOGENOM" id="CLU_078299_0_0_1"/>
    <dbReference type="OMA" id="WRVMKGV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="25060" checksum="18A3AD1A69667343" modified="2015-03-04" version="1">MKLNDSEENPILTQEENQILESYNQLLELHQEVALEKAKSKLKRDEPVHVSELDISEAQDALLKARALFQVRSNVTESVIITNPVLKAVHADVGTSIYQQDLIRLLEKRDELSFSLSQLSRKFSNLQDELLKLEVENIRLTSENSKLTTSMLDFLEASSSKDKNNDSSQSLQELDEISSAVKFARRRWKIVKGIVSGLIVGSGIDWSRDPKLLDIVLEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P598</accession>
    <name>A0A0B1P598_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001414">
        <property type="protein sequence ID" value="KHJ33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P598"/>
    <dbReference type="STRING" id="52586.A0A0B1P598"/>
    <dbReference type="HOGENOM" id="CLU_676513_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="46426" checksum="18FD986D5E50A197" modified="2015-03-04" version="1">MVLLMDPQSIDRRMDRYALDALQNWEQSCLKNIIYDRVPQFGESIMTYTIQEQFSEIQNTARRHLNPHYDLHRTRDQNRVCQSPDQGKINIQTQRYVHETDRELWNEPLKVHFEDQKDADCSLDQFARLNASNNTSSGNMQSNACELGVQLESFSLGPSKKRQRINLEEILIEETSKTTGTTNNDPDLARSIKQAKKMKKALKHLGEIVGREGYRPTNYIDLAKRISIPINLLELWQVNPDAAKEFRRLSTRVNKKKGKRSPTELFSNSVNNYHPRSFTNTQSSSSERKAFRVPVVAQAKANGKIMKLCLGTRGFSGLTMNTADGGATELSHFVSFRIGVCGIWRRIDAFVRPVVKKGGELDLHLLLGLPWLHEVNASIYIRDSKIIVGDSRLKEQIVEIQGPKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A6</accession>
    <name>A0A0B1P5A6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002007">
        <property type="protein sequence ID" value="KHJ32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5A6"/>
    <dbReference type="HOGENOM" id="CLU_029060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="41280" checksum="C73DBD3825FACD77" modified="2015-03-04" version="1">MELSSTSDVTNGYQCSHEFISDELLQDALKIALEATGKRSIYPAPYRGNLFPENDEYKIWPIMKNGKLYRSGSANIGIYFIIYDKQGELKEAVVRGFNNNFIRCMRTRKAPTAPASDPLNKLFVPASKQGYMCGRAFFEDKHLQEVAEIARGFSSNDKLKTKFKKMRFPIERNGELFNRPYLLFPIVRFGKFYGKGNSGWYRVALEVNYKVICAAMIIDGNLKPCEKTTIKGKIQHDTSDYLCGKRVFPNEVLLRSTEEACVKMNGYYNNFYPASYSGPSYGPEGPYYTYPIIENHQDRLRAGQYRVVINASCEFLGALTKYNYGSETRLVKCHRLEDNPNMKFMPVDLNESISEHPILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5D0</accession>
    <name>A0A0B1P5D0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Csep0475 effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001172">
        <property type="protein sequence ID" value="KHJ33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5D0"/>
    <dbReference type="HOGENOM" id="CLU_1612037_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080490" description="Csep0475 effector protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18651" checksum="F106F6B79846462E" modified="2015-03-04" version="1">MLFQASKVIWLLLLSVNLCSAMRGITTAPPDKNGVRIASASCKGKQYNEMIIQMAIRNKLLEVKQQGQNGQNGGDERLSIYKPGPSEKLPFNPPYFFTDLDNNNNENSLKDKVVFTRKGEMVKVVSPVQNERSAQGLKTKESRFEDCKQMPRFVFSPFMPIGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G6</accession>
    <name>A0A0B1P5G6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tpr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002492">
        <property type="protein sequence ID" value="KHJ31894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G6"/>
    <dbReference type="HOGENOM" id="CLU_027223_1_0_1"/>
    <dbReference type="OMA" id="QVAMMLE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="368" mass="42237" checksum="5340AA55BE1BFE6A" modified="2015-03-04" version="1">MQFQQFRLSEKCKKFPTAFILMFISSGILLWTNKYYSDYIIGAFHTFPEPVAKQLRKALFYTNVDFKPGMAMKYYKEAIRIAEELGVDRFSDEMMGIKVQIAILLEKCEKYDKAIEVLEAIRTDNLKWLEVVGFRNGWEARRNKVLQKTVQISVKLGDLYSNNYVLEQELAEERLTWAVEQTLKELQRREREGVKEDEGPWFDDDQIGTQFETLAHLHEEKDRHYLSAPLFLQALNLSPPGSCHTAILMNNLSSSLAQQIRPADYLVEEKTRDSLISNAIAWAENAIALANKIQPPERSEECDTCCAVATHNLGKLAEIRGDLISAKKKYEEAGELSRKIGFKEGIKKAKSALKRIEQEAIEKKQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M8</accession>
    <name>A0A0B1P5M8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002439">
        <property type="protein sequence ID" value="KHJ31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5M8"/>
    <dbReference type="HOGENOM" id="CLU_085757_3_0_1"/>
    <dbReference type="OMA" id="ARIHINQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="135" mass="15447" checksum="27BD6C1D571E103F" modified="2015-03-04" version="1">MALRLLAHPAHLVIPRYIYCAHRFQSHLTTLNQVKEPLAAQKTSINTALKNNLGYKVERTPSNQLPIYHLIKNGGNKKITRIRKIQGNLQELRNDLRKALNLTDKECTINSTTGHVLVKGHKKQEISKFLTDQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q5</accession>
    <name>A0A0B1P5Q5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002227">
        <property type="protein sequence ID" value="KHJ32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Q5"/>
    <dbReference type="HOGENOM" id="CLU_040364_0_0_1"/>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120125">
        <property type="term" value="C:PNGase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000175">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="40257" checksum="905A5896ABF44F27" modified="2015-03-04" version="1">MKLSFRDLKQNKFIIEAEPSDLISEVKQRIADEKGWDASTQKLIYSGKILQDANTVESYKIEEKGFIVCMTTKPKITPATPTSTTTPAPTSASGQVTGANPSPRPPISSNVGDAASTVPTTSSSTSASSSITSNTAGLTPSGISMGAEREAQIAELEIMGFERSQIEAAMRAAFYNSERAVEYLLNGIPENLLSNTLQSATTSSSTTSATPAPAQSAEQEGISRNLFDVAAALSTGTTGGGAGRGSSTNTTTGGNLAGLGNLDFLRNNPQFQQLRQVVQQQPHMLEPILQQVGAGNPQLAALIGDHSQQFLRLLSEGADNDSVLPPGAHAITVTEDERAAIERLCHLGFSRDLATQAYFACDKNEELAANFLFEQPDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R1</accession>
    <name>A0A0B1P5R1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002410">
        <property type="protein sequence ID" value="KHJ32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R1"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="18107" checksum="504CC76FDDFC79AE" modified="2015-03-04" version="1">MAYFTTAPRTSFRVFDESGIARKFKKQQPLEFCKRCNGYHPTKNCSRAPSCGNCGSTNHVEERCMAATKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMRTYRQAGEREYQAVLRAKTAEDLAASTQNEILDTTSSEEPEAENNTNNSQAPLVESSTCGAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S5</accession>
    <name>A0A0B1P5S5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001887">
        <property type="protein sequence ID" value="KHJ32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S5"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="341" mass="37498" checksum="5A1114698AC73E55" modified="2015-03-04" version="1">MIDTMDITQEIQAPSTETSFELPPIPNNPPVPYPLPSTTSPTPPSNSQTLNNITASRKILKPAVPTKRPIPERPSQNSKNSSDDANAFLPRELAEIVATRQRRERAWHTRLMICTTIHSCIENNLSNFSNEIEKEEAAAFKAYIQMAIAKFAAVDSSPSSPQIPTHTRPTKRDGTVKEKSFVKKAVMAPPLKPTGVVLNKEVVKETSNLLENTRATVARAGQKKARVILSGKTQMNPTGRQPIRPANKVKSNSSASQNMAITDKRLFVRLTQEHEWRKLSAAGIREVIVKKLHISPSLIGKIKPIRSGFALIPCSCEAREEITKAESGLFLSGAKLETATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P678</accession>
    <name>A0A0B1P678_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative snare complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001804">
        <property type="protein sequence ID" value="KHJ32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P678"/>
    <dbReference type="STRING" id="52586.A0A0B1P678"/>
    <dbReference type="HOGENOM" id="CLU_033748_2_0_1"/>
    <dbReference type="OMA" id="QASVRSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="313"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="376" mass="41461" checksum="44DD46365B9F121C" modified="2015-03-04" version="1">MIPSLEIAISSTTVSHDVSTSKPFTLYNITLRLPLRTFVIQKRYSDFVSLNAALTSTVSVPPPVPLPGKSWFTSTAGSPKLTEARRKGLELYLRAIAESSDTRWQETSVWRNFLNLPNNISGRNSSIKDDLVAASHRGSNAGELTADPTVWLDVHREMKNHLHDARLFLGKRDSATTTQAQHVAGANAKKSLVKAGSLISNLEEGLKIMCEAERKIGKLAVGAGELRRRKDLLGSAKVEREGLEKLALSLAIKSQSIAGLTASGGDNGILSLEQKTLHEPGMIKSSGRILGTVIHETENTRQLDNEGVLQLQREMMETQDQEVNELAKIVRRQKEMGIAIYNELELQNEMLKKVDDGVDRVGKKIEVAKKRANKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G0</accession>
    <name>A0A0B1P6G0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6478</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G0"/>
    <dbReference type="HOGENOM" id="CLU_040936_0_0_1"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="367" mass="41413" checksum="948D6716D8545B1D" modified="2015-03-04" version="1">MVSQKNRAEPKITFQVPPGQKPLTPEQIQEMQKRLAADAAKNGMTVPEFVEKIKAQAAAAHAAAQQQQQEDGLEPNNTTIMGDDLPQQIQPGPPTPSALAVAKFLKNQDLKVRTCILGGQRKEMFRVKRAYRALESPAYKEAQKKNPLLPEITDRTSLENTFRLLPLSFLALQVSKVDPCKDSCSSSGSHSLKKTKRIKGLWTVEIEQHQECREDLHFVWLYEGPQIKQKLYATGAIACVFVVVMFPLWPVKLRLGVWYLSMGMLVLIGLFFVMAIFRLILFIITMFVVPPGLWLYPNLFEDVGFFDSFRPLWGWQKEKKKGKKKVKNSNSDNDGATISSDVTQINGVKPEQRRKSPTVKVEDASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P2</accession>
    <name>A0A0B1P6P2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001665">
        <property type="protein sequence ID" value="KHJ33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P2"/>
    <dbReference type="HOGENOM" id="CLU_842491_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="37890" checksum="550F15D2CF023B69" modified="2015-03-04" version="1">MMQVAMIQSMLPYIAWPIRVSLEMDEDFIAARRSIHNHSLDWAGAVDCILTILFKHNVLGAPLTNLARLTVHKGKSSLQFARKLRKAIYALPADLILGSEVRDIERNHIQQSLPRTWTSIQRDVSSMSNDELADHVVQVTEGIERWTLEDQVYTTSQNPKPIPLITYENQSVDNADKNFAKELIDFNTPSPDVFTSNHLVTTSPEESNFRASNNNNHCFKCGKYGHWANDCHTNQSNQNKSQSCPNFQRSTFSKNLKDRFLTMKRKKFPNSRNFHSQNDNKTKHRVFIAEPDQKEDDNIIELCGIDQLENDDVDSELENFLHQCLADESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6V2</accession>
    <name>A0A0B1P6V2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002126">
        <property type="protein sequence ID" value="KHJ32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6V2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6V2"/>
    <dbReference type="HOGENOM" id="CLU_024344_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="621" mass="70614" checksum="2EB053E7816C081F" modified="2015-03-04" version="1">MIVLPHPILTGHVAVRGGLNCPPSARKLDLIESAIIRSLLFPNDRNVEANMTLIRSRYYNENSLNTPSGSHQIPHFIPDELDSYMFQYNEQMSGNPQISGTSKENNLNDDLEKVDFNVFGYEPAGSKRVRIDEGVDSEEEYQKMKRAVEANERERYERQSRRQKKGKEREDLDAIPDITQRNLNSDPKTSIPFAGLSKSKSETKLRTIFGREGKGPLDYKKMLENTMITMSMMDFYQASPDFSKTSRKLSTRINEKRVKRKNVAKPVWNVEPEEEELLVEASSSLVEIDCDRKIIPKYHGEKPKIECLTTNTFKIPTVDLKTTPIIRTTTRKDRAFRIPGEVLATRNGKTGKFFLDESMVCADQGSDMVLISPQLVRVLQLQKNSLNEINNQAITMGTADGTSHRITEWVSFVFVTGGIQRQIYAFVRPERVPTLDLFLLLGLPWLHSVKAVIDICRSQIKIGDKNLGELCTVLQGPTFEFAKKHRFLLQPTQIPFKGALRTEEFELKEKTLQNKIKDNVTCRDSQAASRVLGNYSSNKESVRKFHDEKLNKQPDATSFSSDTEDSITVDGSDYEKNHANQELKSASTDPDFSDECEYSSDEDSEDISETYMGKGRVTRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P736</accession>
    <name>A0A0B1P736_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P736"/>
    <dbReference type="STRING" id="52586.A0A0B1P736"/>
    <dbReference type="HOGENOM" id="CLU_022039_0_0_1"/>
    <dbReference type="OMA" id="DIMAPPH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="542" mass="59886" checksum="5C7A18CF2D0875E9" modified="2015-03-04" version="1">MPRPKRSKATPSLTTPRNNKSKIKKSTDVASTTSKSSFNDLYDVSDNEEDRRLRIMDSVNGKDENGQALVSPLAEAFLEMEREQYTEKKNVVTSASGDSSMVEAGPSSSSSSLLFEIGRKEQPTPMRESLALAMGNLKTQVSSTNTDFSKVKSRSEPKSDENKVLGEDTGIKARRSQRRMRQTNTLTSPNSLQNTTQYSPSHVDEFNIDVSTPIKGLNTNISDSSILITSSNSKKRKLSEVQVPQSSFETSPPILSETNEIVPATDPNSIASYGYIEESQKDLLPSVEDRSPTPQDIRDIMAPPHSSSSILSSPVATSRPIKTSNRNLRSLRTRTPSIRIDSDSEISSPPSLTHSPDLPSPTIIKSRDKKPKPSHISMSTAQLKALLPRRRRRIARDVSEGVDSDNEINISGLASDEDELTHLIVGPQVQTRNMKLLKGPQARTSVLRKNPIEISKVNTSTSRTYGSADNKVHSGLTKEIEDHHHKLPVENSDNLNNKPQELDKRFIGQELKKAVQKFKEVDNWALEFEDATSSSASPKDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P737</accession>
    <name>A0A0B1P737_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="12" type="ORF">EV44_g5228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002049">
        <property type="protein sequence ID" value="KHJ32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P737"/>
    <dbReference type="SMR" id="A0A0B1P737"/>
    <dbReference type="STRING" id="52586.A0A0B1P737"/>
    <dbReference type="HOGENOM" id="CLU_032730_1_0_1"/>
    <dbReference type="OMA" id="WSFTQGL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015917">
        <property type="term" value="P:aminophospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="46"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="119"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="427" mass="48037" checksum="BD9C0E95CD01F5E7" modified="2015-03-04" version="1">MFHLMMPDHSPNIETFSSYSFIQGLLLGQLSIVILIGAFIKFFIFGDPPSPETTASLYAAKRRAYSLNHKRSLLSVRSSAQYPRTPVLNKKRSSILRNPPPLTTNTILSKTYYHVNSHQPESLDWFNVLIAQTIAQFRADAQHDDAILTSLTATLNGNSRPDYLDEIKVTELSLGEEFPIFSNCRVIPVDEDGFSLGNERELNKIVGGAKEPSRLQARMDVDLNDFITLAVETKLLLNFPKPLIAVLPVALAVTIVKFSGTLSISFVPGNPQSATVLTFSFLDDYRLDLSIRSLVGSKSRLQDMPKIAQLVERRLKTWFEERVVEPVFQQIELPSLWPRKKNTRGGEEEVHPSATPTLGKERDRKTFESTRKNEDFQCQTGANTESPAQNQDGASVIEREKIRMRRPNLEKYTMIGSIASKILNGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P763</accession>
    <name>A0A0B1P763_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001841">
        <property type="protein sequence ID" value="KHJ32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P763"/>
    <dbReference type="STRING" id="52586.A0A0B1P763"/>
    <dbReference type="HOGENOM" id="CLU_057573_0_0_1"/>
    <dbReference type="OMA" id="YYFCPKL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="132"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="50184" checksum="EAA8832651328AD2" modified="2015-03-04" version="1">MANPQSEDSSRNTNITGAQDLNGDFKPEFSDQSPPQLLLLPKDLSKDARIISLKHPRGCNDTYYLVCPIKGVYELRTITESESTRRSLFLYPNHKGETRGNETDELKTHPNHNGYIMRNASLFVATLIDPLFLILPSLVPPINTKSSAHQKSLYLSFDDYLDRLITDSPRFVYLTNMIPIRRKLFQRMIAVCDSVDVDDEKMYRLNEGELAKELIRKALRMTEGGLPPSIEEKFIKKALEVPATKETFENNCKSDSPLVEEKKEGENLSVKGDQLKKIDPLPSMIRSVDDEPTTNMTLINSELLSDDHLAQKLIYKDEVSDLLRLKTCLLFIISNYITPHMGEFLKNLLFVQNSVISFISLENHLTKVAKLRQDAVNARFNDDYSRKRVRPGDDDSETRAEKRKKEDKLKKSVSCSRGVNALKKANISGMKKMSEFFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A1</accession>
    <name>A0A0B1P7A1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000809">
        <property type="protein sequence ID" value="KHJ34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7A1"/>
    <dbReference type="HOGENOM" id="CLU_071111_1_0_1"/>
    <dbReference type="OMA" id="ASIMTAK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="29715" checksum="678FF9CDBC4D0298" modified="2015-03-04" version="1">MFKRHTKTKKSGVKKITKVTKTNSFQDKTKLTNIKRSLDKDTLDGSTLFSPIVTITVGREGRIFAAHEDILSLSPFFAVVFKESTFIIAEKKKISLLDEEPEIFSCVLEYLYKGDYFPRLIKGKSKGSWSLENGTDPRSFGVTCYISNMNEYLLRDTVIYCAAEKYGLDELKNIALKKQGLHRGIEVALILRSARFAYANTVISDSKIRTHYISLIIRCRKTFRNSGTMQMEMENGGRIFFDLFVALCNQMDDYATKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C5</accession>
    <name>A0A0B1P7C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gnat family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001810">
        <property type="protein sequence ID" value="KHJ32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7C5"/>
    <dbReference type="HOGENOM" id="CLU_096760_0_0_1"/>
    <dbReference type="OMA" id="FREVPWN"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800:SF1">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="23656" checksum="B4B325FE1C66FB45" modified="2015-03-04" version="1">MDSLSILAMAAAQVQQQELSQSNETPKNDSYPADRNSYTYTIRKGKISDIPFLRHVEISAGNRYRTIGLDVVANSNIVGPERLASMTDSNHLWVAVDKYGPIGFLCGEELDGNFHIVEVSVSHECQGRGIGKGLMTTMLEQITMERCFKSVTLTTYRSVAWNGPWYSRMGFGEVHPRLLGSAYDCILDTEEAQYGFDKQERCLMMKDLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7D6</accession>
    <name>A0A0B1P7D6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001965">
        <property type="protein sequence ID" value="KHJ32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7D6"/>
    <dbReference type="HOGENOM" id="CLU_024818_3_0_1"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="134"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="46088" checksum="4B13092CB8377AF0" modified="2015-03-04" version="1">MSGFQRSFAKSKLSSFSTLDELSDEEESKDSNLEHQKQQLGLNIDQQEDEESLSGSSVASTTTIKPILKSQDDSTSSSSISRPLVGSVKKRVFTPLTWASFFEREFYIESETNSIKVTHHAYIILPVNDKAPLFVMHHGAGSSGLSFAQLAIEIRKKLPSAGILSIDARGHGLTKISPTPVVIDLSLDILSEDLLLIIDQTRKKFMWKEIPPLVLVGHSLGGAVITNIAKSTRLDGNLLCFAVIDVVEGSAIDALKSMQTYLFSRPSNFNSLDSAIEWHIHSRTIRNPKSAQVSVPALLKDIADSSYSWSWRTDLAATQPFWESWFSGMSKKFLEGRASKLLLLAGTDRLDTELMIGQMQGKFALQIFPEAGHFIHEDLPERVALVIVDFYNRNNRRALVLPPKVDDMLRAGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R8</accession>
    <name>A0A0B1P7R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001477">
        <property type="protein sequence ID" value="KHJ33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R8"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="13160" checksum="3BB1EAF58579E43A" modified="2015-03-04" version="1">MVHDIDIAIAISTTLSMIIKKIGIQQIPIVICTDSYSLYECVVKLGSTKEKRLRINIMTIRLSYERRELSEIRWINGNDNPADAMTKGNASKALKSLIENGELLIRIEEWVQREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7S1</accession>
    <name>A0A0B1P7S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001472">
        <property type="protein sequence ID" value="KHJ33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7S1"/>
    <dbReference type="HOGENOM" id="CLU_2198945_0_0_1"/>
    <dbReference type="OrthoDB" id="10339912at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="108" mass="12395" checksum="B1BFA24F11A99CC9" modified="2015-03-04" version="1">MDIFKEKHELLEARQAAIEAAILDLENGAVKDVSAAARAYKLSEETVWEQVIDLGLHLRWSAQNNEKLQREREQKDAKKKKILPELMEETERLPLTATSKCGEHVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7U9</accession>
    <name>A0A0B1P7U9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001658">
        <property type="protein sequence ID" value="KHJ33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7U9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7U9"/>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="OMA" id="IFSWTVY"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="1">
        <location>
            <begin position="421"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="595" mass="66698" checksum="C278C5B4E566EE15" modified="2015-03-04" version="1">MMINQVESPDICHGMSLDFVQSSILSTLVPEGNILDFEKLLRETINCFDIKKENHLTSIPQRQTLFFDETICVYAVLQTSNIYEKKLNSYLKRLSITTAGQVICSNSEKKDIFPAQEIIFTECIQNVENPLLVIQEPHEEDKFSTERCIYVVWKFTVLLDRAKIRVQGPSILFTLRASLRQTDFIDESVNDEYIPSQIPSAVNLLEAFSNDSSIVVKPRLSALRISSGTTLNQHSAKNSYQFKVMESMPIKIFPAINAKVKCSRFITGSTDIGVMISVEIDITPFTEYDVTIQMIKLHLNGGRVEDLNNKSGLSLPVTSSPMDSLSFTFILSLNESDRKKSVQDLEISINASVNLSSVCQSNIKMNWIASLSFTSPVNPGFLAPPSSIKRYHNPNQLSIDVDTPDSSLIGNTIPIIHSGTLTSVPRSITHELSDSVTDFGITVTFTSSSTSSPIYPGIPFIWNVFILNRSDRFRKLALIVMPKNFHEERVDSPHASTSKERRFEVAEAVVDENLIYVMQKSSCRAVEVICLSTKQEVGPLSPMACHEVELKFMALDFGMIHVEAVRIVDLDTHTHIDVKDLPTVYISPQVKELQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P895</accession>
    <name>A0A0B1P895_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ribonuclease h-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001778">
        <property type="protein sequence ID" value="KHJ32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P895"/>
    <dbReference type="STRING" id="52586.A0A0B1P895"/>
    <dbReference type="HOGENOM" id="CLU_008679_1_0_1"/>
    <dbReference type="OMA" id="HKAGPPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="324"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="735" mass="82419" checksum="7660C5D48E419CC6" modified="2015-03-04" version="1">MPNKRENESRGQSQVSPKKRKFEGNHGHNSSSSGSISPSIEQNENCGTSKEQHSSDTELLAEIIDNKITYMSPSKKKVKKIPKSESDNYPSITFSKECKLQNQIKISDLQSLILYILADGTSPNFVSVRNRSQIRKVVTLMVPGLELSMFDKSLVNKQEPTFSSPGFYYPKILQADLLPDNLKLFADMFEHVWPVKTPGNDKNMIMFSPINAMLTAPIQRSTDEKRVLKKIKGAKPAKEPFGWKNKPVFVAELCHSPEELLENEFVLHPSMYNSKHEKEELLEHRKLTKTSEDFGWVDTLVSKFEVGHISNNETEDSTTTSGWEVLAIDCEMCLTGESEFSLTRISIVGWDGSVVLDELVRPEKPIINYLTQYSGITEKKLENVTTTLSDIQKKLITLLHPRSILIGHSLNSDLTALKLTHPYIIDTVILYPHPRGPPLRSSLKWLAQRFLSREIQKGHGTDGPGAGHDSIEDAKTCIDLVRQKCEKGKEWGTSESQGENLFKRIARTGIHYKCQNKLKSPYSQDRKSSAAVDWGHPIKGLGAAADFPIGCNNDEEVMEGVIRAVKGDNDGREIPGGGVDFIWARLRELEAIKGWWNSNRQKNTIDIEVQEKLDGENINIDLGSTPSLPTPLKAIPSSSAYEDSADIASQVIANLTKRIFNIYSALPPCTAFIIYSGSGNPVEMSRLKTIHSTFKREYRTKKWDQLSVKWTDVEEQALRKAHLIAKNGVGFLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L0</accession>
    <name>A0A0B1P8L0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="11" type="ORF">EV44_g2351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000800">
        <property type="protein sequence ID" value="KHJ34593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L0"/>
    <dbReference type="HOGENOM" id="CLU_048143_0_0_1"/>
    <dbReference type="OMA" id="CERIHAS"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="326" mass="36692" checksum="4022C03B0E186B38" modified="2015-03-04" version="1">MNSSPNSKQGLSKIQDMPSVSTIETRESPKRISQLSPYIPTQLEIILLSIYPTTLVIGSLYSILNPATRSSPYNSNTQSHSQNTPPSYFAKKNNIFNTFFVKRGWAWITISYLYFLFSHPFTGSAGTLSPKRIQGLLRYGIVTLWWIFITQWFFGPPLIDRNFTLTGGKCELALSSHSYRDQRKFLTASACKAEGGHWKGGHDISGHVFLLVLGSMFLFEEVLHVVLRRRQEERIITMKDGAIKSASIVSENRFPTESLGIWTLGSKIAIGVATMCLYMLLMTAAYFHTWFEKLTGLMVALAGIFIAYFLPRIIPNIRTVIAMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N0</accession>
    <name>A0A0B1P8N0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative family a g protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001665">
        <property type="protein sequence ID" value="KHJ33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N0"/>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="OMA" id="ILWTAYP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="274" mass="30381" checksum="78ADF686199F9844" modified="2015-03-04" version="1">MVDQMEILMANEPPSTDSILYERVGTLGSRTLWVVFVIMILSSISFAFLSLRVPVQKRLFHVLTTFITLFAAVSYFAMASGDGYTYVAASTPLTSYRQVFWARYADWVVTTPLLLLDLAFLAGLDGASIVISLVADILMILLGLFAAFSHNENQKWGYYAFSCFAYLVIVYQLAIPGRRAVSNKQNSTANLFAAIGGFTLILWTLYPIVWGIGDGARKWSVDSEIVAYAILDVLAKPVFGFWLLLAHDRNAESIEGFWTHGLSTEGGLRVGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Z6</accession>
    <name>A0A0B1P8Z6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fyve phd zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001438">
        <property type="protein sequence ID" value="KHJ33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Z6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Z6"/>
    <dbReference type="HOGENOM" id="CLU_026721_0_0_1"/>
    <dbReference type="OMA" id="GDWYCME"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="609" mass="68343" checksum="ADD91B322AB7578E" modified="2015-03-04" version="1">MEDLDQECIICTLNLDVVPTFLHSSAKGEALAGCTELPGDSHPCKNNDLRAVAVIKPCNHFLHNHCLQEWSQISNTCPLCRQSFNLVEVLDTVNGAIISSYTVKDKKQEATLDLPTWTQDDNEEDEADPCPICNESRNPEVLILCDACDANYHTYCVCLDDVPLGNWFCMECADIGAYTRAQGVVSAFTPVEQAIMPRPSRTQAGRRRNRRRLRNDSWFGPWNQIGHRIHGATGLDIDFSEDEEIISWRRLNQDSVLDETQRNIWRMRMNIARQQDTNWSPSSFIPRTPTPIETIEETKAWGDFEKAKNINITSPMTKKRKPRSIVASSSTSTAAESSDPEPQRKLKRPRTRKVLDRAESSSSAFKTPISQSYHNLNAAAVPGLMSPDANDEPSFLTSLLREVNTASGLDDTRSILPATTKLPHRVTSPQAEPSSPLLSPASSSSSYFHSRITSRATPSQIHSRSLSPLPLTSRIEPVFSPIEYPFNRIQRATSEEISQKIIEKDMQRQLPPDKKPPIKENPLTSISPARATLSSESKRDINQIVKSVLEPYWRSAEITKEQYGCINRDVSRKLYETLANHNLDDQGKDRCKMIATAQVAIALESLMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P991</accession>
    <name>A0A0B1P991_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative aaa family atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P991"/>
    <dbReference type="STRING" id="52586.A0A0B1P991"/>
    <dbReference type="HOGENOM" id="CLU_017985_0_1_1"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="540" mass="59326" checksum="68B8C03F9FC5C875" modified="2015-03-04" version="1">MVECPICGKAVKPRDINAHIDSSCKTFTEPDSPLPLSQPNSKKASVSTFFQTPAKRTASSTTTKVELNTSTRPQPVPSTQDTASLTPRKRPFNEPNYTPNDSYQEQTPDNSKDPEPSEKKKKLNNLEKVAPLAEKMRPSSLDDVYGQDLVGSNGVLRALIEQDRVPSMILWGGAGTGKTTIARCIASQVGSKFVEINSTSSGIAECKKIFAEARGELSIVGRKTIIFCDEIHRFTKTQQDVFLGPVESGLITLIGATTENPSFKVQNALLSRCRVFVLSKLTDDDILHIMERALTTLDHPQEIIDKDFLQYISAFSDGDARTALNLLELALSLSTKAEITKSEIKSALTKTLVYDRASDQHYDTISAFHKSVRGSDPDAALYYLARMLQSGENPLYIARRIVIIASEDIGLADNSMLSLATSAYVAAEKIGMPECRISLAHATVALCLAPKSTRSYRGLNNAFAALREPGVAALPIPISLRNAPTKLMKELGYGDKYKYNPNYKDGKVKQDYLPPQLIGRTFLEDRDLGTEIDPEAWDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9C5</accession>
    <name>A0A0B1P9C5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2088</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 11"/>
    <dbReference type="EMBL" id="JNVN01000667">
        <property type="protein sequence ID" value="KHJ34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9C5"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="261"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="593" mass="68442" checksum="F45CD49B917F29FC" modified="2015-03-04" version="1">MTDANPNVESEPNNASQNLTLYFDEVTGENVSKTELKRRQKQRQKQKEKLQREASAPKPVTSSSKNVEEDEKKLNPNQYFEIRSRNINKLRQNKNPNPYPHKFHVNYDLRNFVEQFGHLKSGESKKDVEVRVGARIFNKRASGNKLVFYDVRTEGVKLQVMCQLQESKQGGVPFSEQHEHLRRGDIIGIVGYPARTAPAKKIEKGEEGELSIFATEVILLTPCLHQLPDEYYGFKDQEQRHRKRYLDLIMNESTRNSFLARAKIISFVRQFLDSRDFIEVETPMMNPIPGGATAKPFKTHHNDLNMDMYMRVAPELYHKMLVVGGLSRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADVYDIMELTENLVSGMVKYVTGGTTTKYHTQHGEEYEINWAAPWRRVEMIPALEDATKEKFPPGDQLHTAETNEFLKNLLKKVKVECSPPLTNARMLDKLVGEFIEETCVNPTFITGHPQMMSPLAKYHRTNPGLCERFEAFVCKKEIVNAYTELNDPFDQRLRFEEQARQKEQGDDEAQLIDENFCTSLEYGLPPTGGFGMGIDRLVMFLTDHYSIKEVLAFPFMKEDISAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9L9</accession>
    <name>A0A0B1P9L9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mak10 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001303">
        <property type="protein sequence ID" value="KHJ33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9L9"/>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="OMA" id="QMEWIVQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="336"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="757" mass="87361" checksum="21F3E3D2C39F6CDB" modified="2015-03-04" version="1">MSTNSVNSVVKEIEVLDINNTTREFSSTCTDQSYTLVKIKSRGVIATDITEQFISAVQLLDAGQIIQDSNFTLFESVGALEIMNKKMDTGYLELGETMEDNYDFSKELLPEEVIGIIDQLLSHEMAWHMGHPLAQTIFTSLHIDRILHLCTSSINEAYFDQDTTSERLMHRTLRAYCFGLIKTCCYVYHRINAEHFYEEEDFVSHTFNRNLLKDIELTSILSFMEETINLVTSSETDSKYRTALHSRLQFRVEFLTAVENADLRSFNPKFTIWKNLILIISELEKTAFLGTQVPSAFSEKLQRKLASTVPPRPIVQIQAEDALNHLKKMCLDISILTQVLEYYDCHSLLTFILMFQARKPQPSTYVRALLQHYIFGETFILGNLPIRQVIDENLATTVLPGNLLLKRENDEIELPSDPRHKIANQMEIFRSRAIGSYLEMLRTLCQNRCRIRRSLCHTIVDWDNLQLDAEVIDRNLQDLMDETPIFDLGVSSDPMWSFPLSSWAYYYKICQMEWIVQLGFELETYQPNELAGMYWYLSFLGRKRFQHVERMRKFVNWSYCEAHKNCSITPDSYTELSEALHFLKIAKLSLTATCNFANALSSLFTALGRLSLIKSPPQPYSDDSLRYEARMKPFTLISLPEFIPFDEFTKFVTQPDEKTLNLLNQATKSATEAKKAIEEMSKLSPKESYCRGSDESWIKDIKNTLKACIFTKITISNITNIVKASGNSNSINLTVEIPKPENRYHYWWIVPIILSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9P5</accession>
    <name>A0A0B1P9P5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001292">
        <property type="protein sequence ID" value="KHJ33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9P5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9P5"/>
    <dbReference type="HOGENOM" id="CLU_054813_0_0_1"/>
    <dbReference type="OMA" id="HNKGAQK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="329" mass="37956" checksum="63002F1DE5BDE806" modified="2015-03-04" version="1">MTSNTNLYGIPKPKKASKEISSSNFLAFTSTLTPLISSARGTSSGRPRPSKKGSSIFKDNKKIPKFNSHENGSHCFSSKTKGEKRQKIEVDEAILHRSKRKMEAKAKIYAQMKRGEVLENVETLVDFDQKWAEQEDAQSDSDSVVEDDQESLIEYEDEFGRARRGTRAEIEKIKRQRKVALLSTEELGRMSARPAVPSKVNYGDNVQCMAFRLDEPVATKMEELAAKRDRSLTPPEMRHYEADKEVRTKGVGFYQFSKDEALREEEMKSLEQERIETEKRRKEREEKRKQRLLEIEERRKVIQEKRIIKQADSFLNSLDNELNSLDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9X6</accession>
    <name>A0A0B1P9X6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g2066</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01001413">
        <property type="protein sequence ID" value="KHJ33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9X6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9X6"/>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="415"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="580" mass="65860" checksum="D0D56B3B2A836BD3" modified="2015-03-04" version="1">MDLIKSTVKDQKILPKNSSIPSENERFIRACSDIVRFLVQEHEAQQDSSNPKRDINLNSIRAKISKKHKLSNIPPLTSIIAAIPEHYKKYLLPRLIAKPIRSASGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVDQIKSLGHSVDKVEYIIMGGTFMSLPESYRDEFISQLHNALSGYQGKDVDECVAAGEMSNIKCVGITIETRPDYCLQPHLSSMLRYGCTRLEIGVQSLYEDVARDTNRGHTVSAVAETFCLSKDAGFKVVSHMMPDLPNVGVERDLDQFREYFENPAFRTDGLKIYPTLVIRGTGLYELWRTGRFKNYTPNALIDIVARILALVPPWVRIYRVQRDIPMPLVTSGVENGNLRELALSRMKDFGTTCRDVRTREVGINEVKNKIRPTQVELVRRDYVANGGWETFLAYEDPKQDILIGLLRLRKCSQKYTFRPELVGQPTSLVRELHVYGSAVPVHARDPKKFQHQGYGTLLMEQAEKIARCEHRSTKISVISGIGTRDYYRKLGYWLDGPYMSKKLHFNSDDESDGENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA75</accession>
    <name>A0A0B1PA75_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000984">
        <property type="protein sequence ID" value="KHJ34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA75"/>
    <dbReference type="HOGENOM" id="CLU_1595781_0_0_1"/>
    <dbReference type="OMA" id="LANDCNY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="167" mass="16613" checksum="4C6235E0FB7BEB02" modified="2015-03-04" version="1">MESSFELELDYIDIAVAVAADDVAEVAADDVAEVVAEVVAEVVAEVVAEVVVVDVAEVVADAVAVADAIADADAVFVAVAVVVAVAVAVVVVVAVAVVVVVAVAVVVAFAAVVSGADIVATDDIAECNEGVESIEAAEVVEVAPVSQGSANIQLQQKMSEAAHFDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC8</accession>
    <name>A0A0B1PAC8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC8"/>
    <dbReference type="HOGENOM" id="CLU_1846600_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15246" checksum="FAFEA855033F5107" modified="2015-03-04" version="1">MTSREVLSSVKEPPDDSTRLECAISSLAFIKKKAHDLWSNEHCTNDDLNISYPATGEPAKSKSSPSRGAGVNAQHALHDWDSQEDSHNPSLQDSHLSPRVSIAFVSTSCSLQHLFSRSPPRLAQGVCVQGLYTFTKNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAE4</accession>
    <name>A0A0B1PAE4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000309">
        <property type="protein sequence ID" value="KHJ35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAE4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAE4"/>
    <dbReference type="HOGENOM" id="CLU_002863_0_0_1"/>
    <dbReference type="OMA" id="PQACLYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="4">
        <location>
            <begin position="503"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="838"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="869"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="904"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="940"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131185" checksum="B7D7C5CD5ED0D70A" modified="2015-03-04" version="1">MPIYSNIASTLARQGPRTLTYGYAQSFIAATHPQVYASQNRSGLSRYRANKIGFLSIHQFQNAFQNSTPVTTPITHVRGDKCDGGLDAYFEAWKKTHVAGEPEKEWTQFQFAKRIEWKPGSAVTEDESTNKIPFDKIENENTSESTSRHEIEGTFLTGDLTDKSAQLAKIDSAEKKTEGIIEHTNSETKSGLLPSQCSRSFLNNQEQLSTVITNRKSYFVSSYDTPSDSQSQKYIDQLSDLLKDEKYGEIPATFESMLVAGVNPTVAAYNTLIEAATHISVDRNNASSKTLEIYSDMLRRRIIPNTITYQKILTILASRTLEVDKLRKELEMKRTRFGGMDFNGKFMLASSEIKYASLVKDDSINYLTQIYDTSVASHTVHIYPTETYQNLIAACSITGCRSHLSKVFEDLKAQNTIPDVTTFCLMINGFSQFGELDKAVEYYNMYKSLAIDNNNGTLDMPDRQDHLVYASLIKAYIISDRISGALKFYTKIIDSYAENNFSVSESIVYKGFVKGFIERGMLSEALKWAESLTGPNRLIAMADITTAAADLGIRSVADTAYAHLPHCSQDIILSPTISMLALSVREGRIQAAEYYWHILSNPLNIASSLFIEPTAMFAVAMIGSGKILEGLVSSEHMFDRIRKSTVDNTGHLYSEIDEAIGLINNFISDRGIFDPRIHIPDNASLQNFIFPSLPTPMHEDFFDPYATNTDFKGSSMISDELDRVSSCGRDAKLNDAIYHFRQIRRTGRHPRYNVYAKLILATAREKNIDLVQEIFGMARIDVPLLQQYRSVRYGWISILDAMIGACLTLGDRNLAAHYHQELLSIGAVPTANTFGLYITTLKGCTKSFDEAADAIKIFNQAKNEGVKPSSFLYNALIGKLGKARRIDDCLYYFAEMRYLGIRPTSVTYGTIVNALCRVSDQNLAEYLFEEMESMPNYKPRPAPYNSLMQFFLNTKRDKSKVLSYFERMMKMGISPTSHTYKLIVDAHATLDPINLAAAEAVLDIIRSTGQEPEAVHYSSLIHAKGCVMHDMDGARVIFDSVIADPSIRPQACLYQALFEAMVSNHLVNETEPILEDMPNKGVEITPYIANTLIHGWTAKNNINKAESIYLSVSPDEREPSTYDAMIRAYLAVENRLGASSIIKEMLSRNYPSAVSSKICELLGNNHTENCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAF6</accession>
    <name>A0A0B1PAF6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative prenylcysteine oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001135">
        <property type="protein sequence ID" value="KHJ33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAF6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAF6"/>
    <dbReference type="HOGENOM" id="CLU_021176_0_0_1"/>
    <dbReference type="OMA" id="SIGIWDG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="115"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="506" mass="56506" checksum="4506507435EBA597" modified="2015-03-04" version="1">MAHPGYNRRIAIIGAGAAGSSAAYYLRKFANKAGLNVNITVFEKNGYIGGRVATVNVYDDIYQPTELGSTLFIDANSILKNATDNFNLNLDSIAYDDSFGVWNGHEIVFTQESDTSASWDRLKLILKYGLVPLKFENLKNRILDSFLKFYEYPIFPFSSLTSTVFDLGLNSTTSLTGAELLEKNNIKGPFLEEIIKPSARVAFGQSTDTMHGLQTLVSMAVEGAMSIKGGNQKIFQEMIKSSNCSTFLNTSVKNISPSSIKRGYNITWLENIEKSKLPIINYEHFDSVVLTTPIPFSNISLENITLKNVPKEIRYIPLHVTLFTSPHQLNPVFFNIPKDKPVPATVITTLPSIPPPAFKNGPKPPVKGAPEFISISKIRSTFNPSSQKSENLYKIFSLNAVDAILLSGLLNTTVATNLTTSPDTISWYYPYVWENAYPYSHPRDQFDEPQLTHNFWYTSGIESLVSTMETSALMGMNVARLIINDYQETINNQMQSFKYQPTRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAK6</accession>
    <name>A0A0B1PAK6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gtpase-activating protein gyp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000292">
        <property type="protein sequence ID" value="KHJ35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAK6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAK6"/>
    <dbReference type="HOGENOM" id="CLU_039465_0_1_1"/>
    <dbReference type="OMA" id="VYMFAQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="58"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="45845" checksum="E7A3294D624BCD2F" modified="2015-03-04" version="1">MDFKESNLHEKLEQKSSTLQLQSPHPEKYQDKVSKILQACKGKHLKTLRELATSEGGLVSDFLRRQAWPLLLENLPAHTDEDQVRLDVNRSFVYYPRDQSSTDLIQRKNQLFDLITSVLRRYPYLSYFQGYHDICQVFMLVLESDSYKPALTRLSLLRIRDFMLPTFSHALAQLHLIPSIIQRVNPMLWKHLSATQPFFALSGTLTMYSHDIPDYEKIARLFDVLLAREAVFSIYLFAQIVLQQSDELFKTPSDEPEILHSILSKLPNPLGIEALIKNTANLFEMHPPEDLRGWRSISNNSVLKTTRWIDQALDQSLDDGQKFFVRQVRELEWIEKRQLIMKKINKFWKPTLTVSLPIVLGILLYWWRKSFEFADIFRTWPCVLNVFNNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAK9</accession>
    <name>A0A0B1PAK9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAK9"/>
    <dbReference type="HOGENOM" id="CLU_421032_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="74461" checksum="C08C7373F73F087A" modified="2015-03-04" version="1">MSLQTSLKAIPINRDTENQSKFINGKEILEISVCQDSEVLSEGTKSHTSKLLASHPVKISFYNPQDSLISPVKEAHIEEKTSLEELASTLQDLLESITTGLCEPYQIKSVHLRILNQESYRNFSWPTPETKDGNDIQEYSEKLIWDQLEKMEADWIKFRSKILTDDKNPKKIRYPILVVQTIRSYEDTRSLPNPADNELTSTQKLTISSNSEKEDVEKSVIGSVSEIPFFTKRHNTETNFKDDENIGKPIIENENEIEEGFEIRNKDLMPKNLVEKASTQLEMQNREIVENGDPKIQETLPSQLKSQMDSPDPSMEEQNKSSISNIVPIENLQTIGDLEKRKINAQIIPSESAFTCLPDCHEIDNKLSSQDKGLKTTTNSFKDFKAGYLSPKLTRDLEKYRRFHESAVSYANEDEEVFFPLTPDSTPKLYNVSENQQTLGDKHQITQLDLDKIVKDAISRKMNKKRISNLELQVSPILNLSEDMIYDQQYLLGQGFTQDMSISQEQSELQQLELMYAYNMYEQGDKTHNQISPGYYLSPISKNYAGMPSMIPEQNLLSDYGVDELNYMGHNLPYISGGIVDYPNNDYNPNNLYSSPYSTPNMLGSSGAYYMNNSYHFDSGYPHINSKYVLKNRMNIPSPRMWNKAHSRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBA4</accession>
    <name>A0A0B1PBA4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative high-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000177">
        <property type="protein sequence ID" value="KHJ35977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBA4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBA4"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="OMA" id="WNANNIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="37194" checksum="57EF9F3890F7E044" modified="2015-03-04" version="1">MWYRRHECGFRIALFFSAATAAGAFGGLISRGISEMDGFGNMAGWSWIFILEGLLSLVVGGLSHIFINDYPATAKFLSTYERDEVNRRLLDDDGLSDEFHIKFLYQALRDKKIWVMMFITIGIFTPMYSISLFLPTIITQFGYSANKSQLLTVPPYLAACLCTILGNYAADKFRQRGLFLLGFEVVAVIGFLMLVTNDMPHVQYLGFFFAASGIYPLVPLITTWTSNNIGGSLKRGVGIAMQVGFGNLGGVIAGFVYLSKDQPRFVTGHVILISSVSMSFVLTLSMTIFYRRENARRDAISATQNLTTESFNDELKLAERDKGDNALFFRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE8</accession>
    <name>A0A0B1PBE8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001117">
        <property type="protein sequence ID" value="KHJ33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBE8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBE8"/>
    <dbReference type="HOGENOM" id="CLU_723998_0_0_1"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="133"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="243"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="382" mass="42156" checksum="96B48F19D316E9AB" modified="2015-03-04" version="1">MKGKRKPNLLSLDTGAANNSSRPGSLASPGIPSMLQRRGLDRSASTPRMITTPMYGPVGGMTLWPQLVGPSRLGAKKPLQDNTSNYNAIAENNSEASTGVQMATLLPGVTVGGDAFDRAHSSEDTSSSSYPNGPILMYEPNIYLYSEPKFEEILNFDVVINVAREVKCPTEIDEIISQGTQRLIDVPIIRLDRAKSDSGLKNITTKSLISIPLEKYQSAKSSKQTHMLEYIHVPWDHNTDVKDELWDLCQLIESRSKIGKRILVHCQQGASRSATLIIAYGMYTNHDIGPNESYQIVQSKSPWVNPNMSLLFSLNDFKKVINENKYAINARTSNNACKSSAPALIDTLSSNTSEARNISYKQTSDPIKFKLETYMGHAWVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF5</accession>
    <name>A0A0B1PBF5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000758">
        <property type="protein sequence ID" value="KHJ34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF5"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="THTIMLC"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="205" mass="23108" checksum="2E29FFFE8F13EFD5" modified="2015-03-04" version="1">MLCGIGRNKSASRKLVLLGDGACGKTSLLNVFTRGYFPTVYEPTVFENYVHDIYVDNVHIELSLWDTAGQEEFDRLRSLSYDDTHAIMLCFSVDSRDSLENVESKWVREIAENCQGVNLVLVALKCDLREQNDDDPQDGGETREKKETINYDQGLTVARRINALRYLECSAMRNRGVNEVFTEAARVALQVNTNGNKGDAKCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBJ0</accession>
    <name>A0A0B1PBJ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane protein 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001091">
        <property type="protein sequence ID" value="KHJ34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBJ0"/>
    <dbReference type="SMR" id="A0A0B1PBJ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBJ0"/>
    <dbReference type="HOGENOM" id="CLU_132206_0_0_1"/>
    <dbReference type="OMA" id="YGFWDIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059509" evidence="6">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="150" mass="16637" checksum="E48911D622B508E4" modified="2015-03-04" version="1">MTYTSKFLIGLGLLFLAHSCYSAHEYSMLHSVGVAPIIQISNQGAVASALPSLPADISVETIVAIIVTCLGLVLSTSSLEPIEWRVWASKIEREGEKRIFDHNFLVKKGYSGNPIKALESRPGFVDIRQQRREFLEWNKNAEGDSQDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU6</accession>
    <name>A0A0B1PBU6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU6"/>
    <dbReference type="HOGENOM" id="CLU_013967_0_0_1"/>
    <dbReference type="OMA" id="IHGPASF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="596" mass="68038" checksum="66E2B52BCAA526BA" modified="2015-03-04" version="1">MSSLYEVVTVVSSIVLRLSAYIFLRWIPSHQFPMVIYTSFALYTPTFLILFYQAQKTQHATTKGCSQTEFPTVKGYTKNSVLEIKLEQKIITKRSHKIWPTLLLGLPSPKSILISLISFTTNLVLVLGVLDLVYHARLLYPVENLSFARLGYISPTEAKLIVREPNTSKLPVYVYYRLLNSTTDREDAPWKDVDIIKSTGNQTDYTATVTIKLPNTPEQTYQWKTSTNHTGVFTTPPYPGKFTSDGDFTFLTSSCIKARFPYNPLTHALQIPGFKHLAQGLKYFPRAQFMLFLGDFIYIDVPKRFGITAEDYRREYRQVYASPDWPLVGQNLSWIHVLDDHEIANDWDRRTTGLYRSAVDPWHHYQTVANPPSPKHILSPNNLTYYEFTQGPASFFMLDTRSYRDSSRDIPAKAKGKTMLGSSQLSAFLDFLRKPEAEGVKWKFVISSIPFTKNWRVNAQDTWAGYLNERKIILEAMWDASHQNNVKIVVLSGDRHEFAATAFPPPDGGKWPLSSTVYEYSVGPLSQFYLPIPTYMQFDNEDVKVKYIPAGNSKFGVITIKKAKSSNHSTLNFQLYVDGLETWSNTLSSPPFLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBV6</accession>
    <name>A0A0B1PBV6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5179</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="JNVN01000872">
        <property type="protein sequence ID" value="KHJ34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBV6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBV6"/>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="OMA" id="WHLPERH"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="415"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="542" mass="61964" checksum="C77B6C2D4BC2D9E8" modified="2015-03-04" version="1">MTTQASLLHMVAVSGTITDFNKKILTSDALNFLALLHNSFNENRKQLLQRRVIRQGELDRGFLPDFLPETKYIREDDTWKGAKPAPGLIDRRVEITGPTDRKMVVNALNSDVWTYMADFEDSNAPTWDNMINGQVNLYDAIRREIDFKQSSKQYKLRSDRKLPTLIIRPRGWHLDEKHVTIEGEPISGSLFDFGLYFFHNAKELIKRDLGPYFYLPKMESYLEARLWNDVFNLAQDYIGISRGTIRATVLIETILAAFEMDEIIYELRDHSAGLNCGRWDYIFSMIKKFRHHSAFILPDRSNVTMTVPFMEAYVKLLIQTCHRRQVHAMGGMAAQIPIKEDKVANEKAMEGVYADKLREVKSGHDGTWVAHPALASIASEVFNKYMPTPNQIFVRRNDAKISRHDLLNMNFAGKVTEDGIRKNLNIGLGYMEGWLRGVGCVPINHLMEDAATAEVSRSQLWQWVRHGIQTAEGKKVEKSYALKLLQEEVDKLSRGGSTGNKYQLAAQYLSGQIVGEDYADFLTLLLYDEITSISSPYSTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBW6</accession>
    <name>A0A0B1PBW6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000285">
        <property type="protein sequence ID" value="KHJ35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBW6"/>
    <dbReference type="HOGENOM" id="CLU_2442502_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="11310" checksum="E0D371191E30E49F" modified="2015-03-04" version="1">MKIYESIPEPKRQRTRRYWIDCGEKEIYNWKEMLNICQEKFFDRVEAQKAERKLLVMRQSESQIFRKFLHDWKLQLEYAGRDWPDLRLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBX2</accession>
    <name>A0A0B1PBX2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000862">
        <property type="protein sequence ID" value="KHJ34456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBX2"/>
    <dbReference type="HOGENOM" id="CLU_128909_0_0_1"/>
    <dbReference type="OMA" id="TMGDKSP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14535" checksum="B571B428908F23CF" modified="2015-03-04" version="1">MEWLDAKNISFILEIDTPTHNRGNVLDLCFSSNSLLAKGCTASVQQDLDVTSDHLPILALVPLEFPIRYTEPKLRIASLNEEVFKTLLTLNITDIATMGDKSPSSIDKKAEKIVEILQSSYAGSAKKVLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB0</accession>
    <name>A0A0B1PCB0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000576">
        <property type="protein sequence ID" value="KHJ35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB0"/>
    <dbReference type="HOGENOM" id="CLU_038399_3_1_1"/>
    <dbReference type="OMA" id="NILFWAI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="369" mass="42406" checksum="222104C6BD936D8D" modified="2015-03-04" version="1">MIGSLPPQALGVSILVFIISIGCLILSSLLVCLLIKCGEKSKYVTLISGFSVLSTLASIFHQIHYVANWKMLRMAHYQQTVKIYHRHGIAFAGVGETWDVVLFYFQFYCYNVMALNILFWAISLFNSSWSSTFSFLGGRYHKLAIFSKVFSLIWPLGEVFISQLPVLKHYPILHIIVTYSTIFFCLSLGSVLLILILYKYIRTRKVASGYDIKDDWWTSNESDDLSDKENIIESYGKVSYKIWDRKRFTYNKALVTRFTVGFVMMGFFEILLISITFYRVKTNEIIVKSGQPDMSASNAIIESLLFLPGVSSSLIAFLVFGTTKAWQDYRDLLWGIHTSYERKIPRRQGKFRRVSSDEESTRPSKVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCF1</accession>
    <name>A0A0B1PCF1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000557">
        <property type="protein sequence ID" value="KHJ35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCF1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCF1"/>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OMA" id="WVGRSAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="57806" checksum="DC28DA4B845E8EEC" modified="2015-03-04" version="1">MDEHQKRVEIIARTIRGFYERKEKWRVDHGSTNSTRPTDVKKSVVQLDSLSNVLEIDPERKVCMVEPNVPMDRLIEATLKFGLMPPVVMEFPGITVGGGYSGTCGESSSFKHGFFDRTINSVEMILATGEVISISPNKNKDLFYGGAGAMGTFGVTTLIELQLQQARKFVKTKYLPMASVNKAIETIQKLSSDPNIDYIDSIMFSPTSGAVITGHLTDTLDSHGSIVRFSRRHDPWFYLHARDQIKSGTVRVDFIPLADYFFRYDRGGFWVGAAAFRYFKVPFNKVTRWALDDFLHTRMMYTALHASRQSKKLIVQDLALPYKTAEEFIDFTITEFNIWPLWLCPLKPSPMPTMHPHSLLGENGSESQAPKGILNVGLWGWGPSDPKIFYEKNKVLESKLKSLGGMKWLYAHTYYEPAEFWQQFDQKWYEDLRTKYNAGSLPNVYDKAKVEIEGRKKEDSNMAKTSFFHKLLEKWPFPGLYGIKKAIESRSYVAARKSEWKKMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCG3</accession>
    <name>A0A0B1PCG3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000555">
        <property type="protein sequence ID" value="KHJ35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCG3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCG3"/>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="131" mass="15071" checksum="BF8F9D4901C45011" modified="2015-03-04" version="1">MVSAKKHIPIVKKRTKRFNRHQSDVYKCVDPSWRKPKGIDNRVRRRFAGQIAMPSIGYGSNKKTRHMMPSGHKAFLVHNMQDVELLLMHNKTFAAEISHSVSSRKRIDIVQRAKELGVKVTNPKARITSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCX8</accession>
    <name>A0A0B1PCX8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative pth11-like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCX8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCX8"/>
    <dbReference type="HOGENOM" id="CLU_947301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="294" mass="32718" checksum="A0472465E251301B" modified="2015-03-04" version="1">MPDPGPHCRQGYAHLLTLGVMNIVTDLLLVIFPIPIIIRSKMCLKKKTQLILLFSLSILPGVVTIIRIPNTIGLHGSQHYRSLLVSVEILIATVCANALVLGSFVRDRGVKKQKFKITSTAESVEPIESIRGKFIRVWGSDEDLVRDLGLGVTPGKFPPIIDRKFSEVSSPKNWRLPGGRRKFSEELDFIKLGQQPESRKGSISNRTSRKVSFADVDDFRGIIPFRRASQMTSYSDAESSTFDRKSSFSVDLETGLCPASLKKIPPVLLSDICNLPKVREEKCIPNELPALHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD14</accession>
    <name>A0A0B1PD14_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome p450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000693">
        <property type="protein sequence ID" value="KHJ34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD14"/>
    <dbReference type="STRING" id="52586.A0A0B1PD14"/>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="OMA" id="WIKATIT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="523" mass="59357" checksum="397114C6CBCEB3B1" modified="2015-03-04" version="1">MSISENFSIIGHTSHFPFLLCATAISVVALWIRYLIYQSKLLRFPIVGKPDNTNIRPILEEGVAKYPDSPFTIPTTPPIVILPKSVINDLKYFTDDKASFWDELKSRFHSNISGFAIDNKMLTTVVRHDVTRNLASSLNSVQEETALSFYRTLGPCEDWTTHNLYSVLTKIVALVSGRVFVGTSLSRNDKWVDVTVNYTLHLNAAKHAVLGWPEWVVNLIAPYMKQFKAIEKFRSRAEEFVKPLHDAYFAEESNGKQASEKGNEKSGVSWFLDRMKPQDRKDPKMLVNQLLDLSFVAIHTTSSSIAHAIFDLATYREYIPILIDEIKAVIAEDSCDTSPDGILKIGKPTIAKFIKLDSFLKESIRMNPLFLASLIRKLNTDVKFSSGFTLPKGSHIAVPSWVINIQSPTLHSPGHTKPLNEFDGLRFFKLRQLPGNENRHLLVSTSPDSLIFGHGNHACPGRFFASNEIKIILIELLLKWDFRFLNDVKLEGGKLRRPMNKFMAFECLPNQEAMLEFRRKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDH2</accession>
    <name>A0A0B1PDH2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDH2"/>
    <dbReference type="STRING" id="52586.A0A0B1PDH2"/>
    <dbReference type="HOGENOM" id="CLU_079283_1_2_1"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20163" checksum="9DF02D7471C4567D" modified="2015-03-04" version="1">MLRRALLGARKTSSVLIRPQTPSIFSQITIPVANISQRQYHEKVLDHYSRPRNVGSMSKTDTDVGTGLVGAPACGDVMKLQIRVDPTNNKISDVKFKTFGCGSAIASSSYLTELVRGMTLDEASRIQNSEIAKELCLPPVKLHCSMLAEDAIKSAISDYYAKNPKTPSTDLSRKGLEPPGPEISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDI5</accession>
    <name>A0A0B1PDI5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mrna processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDI5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDI5"/>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="OMA" id="CSEEHWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="41601" checksum="9066872000A36CA3" modified="2015-03-04" version="1">MLPAHVNFECPDCGIPVYCSEDHWVDDFEEHLQICDTLRQINEDDHDLHSGRFFPEFSYPTYQIEEAMINMTTWDTLLYSREFKAIDNERSLRQVTKLLTYPITIGSILHELSPYNIKKGGRLTVEGLKSLSALRYNLHPQKSGAGPGIKGIRPKSPPVRIFVVGARAESSLPRDVWMQLVYLFPRSDFHLILIGPESMTNRDDEFPLPQRTPSNPFGAIVEDRISPQLKISTYVEYYHNLHKVGQFYPYDPYFDCFMLFHPGLGHPAGSHEWEETLPLLLETKVPILSTGYTNFDMERDVEWVKEKSKGEVDIILEPGENRFRSLRWDLNDLDPQDVTCGNWGVWGFRGKRYEARNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ7</accession>
    <name>A0A0B1PDJ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pre-mrna-processing factor 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000403">
        <property type="protein sequence ID" value="KHJ35430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ7"/>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="444"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="60458" checksum="D3B76F3656763BE1" modified="2015-03-04" version="1">MADLEAYPANVVPQNAIIVRQHAGIDHAVVRYNAEDLSRPLQGPANPFKNDSESLKRKNILTGYAEETFISEFAFRSKLREMERGPGREYRGGVAEKEESARIKSKRQKKGDATVAEGDNAYIGPWAKYKSTQYEEVEEHEQLLSGEEYEEISEEDEEFIKSGTVVSALPQAIAKRKEAEEMGEETSIFEGSQQFDYQGRTYMHVPQDLDIDLRSERTLKEIKNYVPKKMVHQWKSHVKPICGLRFFPDSGHLLLSGSVDTTVKIWDVYHDRELLRTYKGHNKALSDITFNPTGTQFLSASYDRMIKLWDTETGQCINRFTTGKTPHVIRFNPSPEYCHEFLAGMSDKKIVQFDTRTREVVQEYDHHLAAINTITFVDENRRFMTTSDDKSLRAWDYNIPVPIKYIAEPHMYPLTRASLHPSGKYVAYQSSDNNIFVYGANDKFRQNRKKAFKGHNTSGYAIDVACSPDGQFVSSGDSGGYVCFWDWKTGKMWHKLQAAEGAVTCVAWHPRETSKVVTAGLEGTIRYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE51</accession>
    <name>A0A0B1PE51_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rhomboid family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000629">
        <property type="protein sequence ID" value="KHJ34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE51"/>
    <dbReference type="HOGENOM" id="CLU_090064_1_0_1"/>
    <dbReference type="OMA" id="WMGGESE"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="24378" checksum="5A4B5D4A9DB3AA9F" modified="2015-03-04" version="1">MNSATPKQSTDEFRKNVIHYTSWACLIAGPVILLLPPRKLDIYTFGALLGTFAGANEVSREQTGISMIERMGKRFAETTNALPPQAMELQQRRINELKEKKNLQSIEKIIGKNNLPGESTKEELSEKSKKSSNFWSKVWMGGEGENWKEERLRKEREALESGKGYFDLIMEQVWEVWNNDELEKKKDKNNGLEKKNISTDKPLDQISGVDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE94</accession>
    <name>A0A0B1PE94_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative g protein-coupled receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000606">
        <property type="protein sequence ID" value="KHJ34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE94"/>
    <dbReference type="HOGENOM" id="CLU_039213_0_0_1"/>
    <dbReference type="OMA" id="FSVYCVY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="336"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="60426" checksum="9986ED9737CB586B" modified="2015-03-04" version="1">MFLSEKCDKLACSTASHTGSIWSLVLSLIPFIVTFFGLGSLLLYKLFPLISQKTGESLFTVSLPTSPRDSPLLSSRHRSTTSQQKRPNQCRLDALTFATTISLAAVLAELILCEISNALDPVARAYAFKSIIPSLLFSLVFLIPFLEIQSIISASGWSFKNSDSDKTPRVALLLQIFGFSLWLIGFWWLGKGTHIFMISSKSGHGLTAACLERVGIIGIALMALMSGFAAVSAVWHTFGVKTRIVSEADISRKQADLDAINELFVDKQNQLRSLQRKTKDMPTEDYLKKYLGNIRGNSDTQEIQSIEKEISALSYMASSLSSSKVLLQNRLAYSRRASSRLGKTVIMPASFGFSIYCIFRILSTILTNIRILVFSYPSMAAHNSPNTDPINRILSLMAKHIDPTLNRLAWSRQISILLSGFILLASFNSVLTTFHMLTKLSPSLLHQAQANQALLIAQISATYVISSALLLRSNLPNEMKSIVNEALGSPLDPVFVERWFDTWFLLATAGTALGIWTSRRIYGQGVRSWDDAEFEDDLELGQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF52</accession>
    <name>A0A0B1PF52_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rnase3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000197">
        <property type="protein sequence ID" value="KHJ35945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF52"/>
    <dbReference type="STRING" id="52586.A0A0B1PF52"/>
    <dbReference type="HOGENOM" id="CLU_048162_2_0_1"/>
    <dbReference type="OMA" id="WKSSTIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="6">
        <location>
            <begin position="164"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="48144" checksum="F1BC9B34D81DB502" modified="2015-03-04" version="1">MDNKRKHNSDELAERSYKQRKKDALLLRPQGTSTSTSDTENNRTQNSVFFKTVEKCQAALYVQNLVRDLDEILDQDIRGSISEILSDETLKKCLSLQTSLRESKEKIFQKIGKDKSSENFHHENSKLPKILSPLSISPWKSSSIPSEYPPLPEILDPTLEAATFIHCSVSAGRKGALNYEQLELIGDAYMELIATLLISQTFPSLSPGKQSQIRELLIKNITLAKYSLQYQFEKRLKIDWTLLQSTSLTKVKVLGDVFEAFVAAVILSDPIDGVQRASQWLKSLWSMTIATTIKLEDKSENKVQSHLWHLRGNISPEKVAEAFNNQPIELNAKEKLQKLIGGKHAKLSYRDLSPPTKDPQTKLAVFSIGVFLDGWGEKNKMLGSGQANGKKEAGLKAAAVALNNEKLIKLYADQKKALMGLETKDNQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFX1</accession>
    <name>A0A0B1PFX1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative actin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000115">
        <property type="protein sequence ID" value="KHJ36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFX1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFX1"/>
    <dbReference type="HOGENOM" id="CLU_013085_2_0_1"/>
    <dbReference type="OMA" id="HNNEEYI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="628"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="693" mass="75121" checksum="CB6B4E6E04140C0F" modified="2015-03-04" version="1">MASLNTSTNGPSIKSSYQSVINDSFGAGSDSPTYGIWAVFSVSAPLINAFQPDRIGKESILKVHNTGQGQLQDMVDEFSEGRIQFAFVKIKDSNTQLPKNVLIGWCGEGVPERTKGYFTSHLAAVSKIFHGYHVQITARSDRDLTPESIIKKVADASGAKYNRVGDLPLAPNPPTVISKPAFTPSQISKPSEFNYMAHSRLRTSQNNPIVDEDGWGLDAPQVTRSKLEKVAPAYKPTKVNMAELTKQNSSNTETNGGTQSNDSQIIKGGYQPVGKVDIAAIRAQANGNIDDRPTVVRGAYVPVGKVDIAAIRAKAQRPVGDFPSSTSSHVKLEPNEHSPNTFTLADRSEAFTKSERLTALPKPKVANNFGSTASNFMGTKAPQPFGLTPSSFVPPIVGTASKTFADEGGKTPAQIWQEKKARERGSSITLNETSPQNPRKSSVGSEWKSGYTGKSWAPVSTNPTGRSGTGSISNHLSSDQDQEDRLSPVGGINAIRSQFQAQQPVNISTDTSPTNDQNSLPPSINTFTRPPLPVLPPPSQPTSSMPESPDQEASPPLIAIPVARTKESEMISPQKLDISQSNVPFNSLIDDEHEKLQGNNLEHNNEEYIQPEEVDNPTAPAENVSTRSNGEIALILYDYDIDEDNEIQLVEGEYVTNIDMVDQDWWMGTNSKGETGLFPSNYVELVDHIPDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG78</accession>
    <name>A0A0B1PG78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box tpr repeat containing protein pof3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000333">
        <property type="protein sequence ID" value="KHJ35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG78"/>
    <dbReference type="STRING" id="52586.A0A0B1PG78"/>
    <dbReference type="HOGENOM" id="CLU_024395_0_1_1"/>
    <dbReference type="OMA" id="CERVICL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="511" mass="58167" checksum="03238485E5D7733B" modified="2015-03-04" version="1">MAKSNTLNHINFSKKIEYGFDLYIKKDLTGAINAFTEVINNSTDQTLEKALDSRAACYEKLPDLHLALRDGRNMIRIKPDSSKLLYSLHQRLKSELNRNDPFQFLPLEIAHLICKRLELGDLCNCLIVSKGWKSLLESIRSLWTTLDTTNIHNPVPIKSLKTYLRRSNYTLNRAIINLKLSADRGRLQYILEKCKFLKELEVRGSSKLDESLFNIFSSAKEIENLYITQNVLVTFKLMQAILKNCCQFLVEARFSNIQGSRYNFINCQWPRLDALKRVALRASDNGALDIIGFVEATPNVTSVILDRFEVLVKDTLDLRSWSRLERLHLLHAGLLKFPQLPKSLRHLILDDNPYLSISDELGKEFFSLPLLETFYCQSTSIESVNLITILQTSIQSDKLKSLGIGGQMIAVSDSTNNIPKNLPLSHSLEELSLACLPLNDNQIKEILRLYPKLKKIDLSGTNITGVTMKVLIEKGGIEWIKVSDRMGVSFDAVEMARSKGIYVDFRLLPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGI9</accession>
    <name>A0A0B1PGI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000307">
        <property type="protein sequence ID" value="KHJ35669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGI9"/>
    <dbReference type="HOGENOM" id="CLU_021587_2_0_1"/>
    <dbReference type="OMA" id="AVICQMP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="632" mass="71283" checksum="82A7925764035CA1" modified="2015-03-04" version="1">MFLNYGAGLHGHEFSGPKKSLNDNFIQRKSPLISSSLVSSSPLSRRNTINGRSTTSHSQIQNLPLERLPRDVETIIHFQEATPDFDSDMTSDGEAGSLLNLDSEKYQSKKNLRRRKRDPQKSSVFHLAHPAPTLSHTQKFLKILPKIILQLQLLSDKTRPRPYIDVLPSHVLIPRLATKFTRLLRGKGELGSNDVIIVRSENYDDNIEHVIENNYMSEDCYSNRNLIAVICQMPRAKGVSQGVAEIVFSDGSICIATPLPGGLYEIRIKDEGGKEIVARWWIKKYPKRQSIKFQEFADVNADLKYAFSIIDPDCKRHPTLATITHNQLEILDSYTTLSSSSGRYPPTITIPDGLKDQAHVQEVALPERTTRKIDSKMQTLIQVTGIWVSLRQNWCPCFKYNDALAVACTSTHVQPVGRVRPSSLTMMNGYPKPVGDSSNTPESLQNYKRVTNLESAIRRVSIKGRLAKSHLPHNENPVKLERTMSAGSAFVQRITARRSSICESSTTSRKDDYTKTKRLSHDISLERQSTDTSSRSFTPPNGLMNSPLIATPKRTSKEHRRTQSAFYPSSTLHTDSADTYLVIHSNEIGRESDYPFNFKPRASRWKLISNFFRRLGGVSSHQEPNSQNFGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH43</accession>
    <name>A0A0B1PH43_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lin1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000241">
        <property type="protein sequence ID" value="KHJ35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH43"/>
    <dbReference type="STRING" id="52586.A0A0B1PH43"/>
    <dbReference type="HOGENOM" id="CLU_024456_1_0_1"/>
    <dbReference type="OMA" id="EYDQVWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="47575" checksum="6CC36EF5C1D19DB6" modified="2015-03-04" version="1">MSSRYSAARPKRAGEEFARTHHQNNNYSSSSTSNSKKPRFDVRNPSALAPDAAEEDAVLQADVIGTGGMGTKRGAVNIDGYDSDSDNEDFDTRAEQRAKIKGKRAGDAVRLDEAFEDFNNNSNKKDASDDEKEEDDMFGDDDSDQNNTVPSSNGANHKKEVRFLEENEILGQVENSKSRGHISGNFALDPNGKLSSHALDDEISSDDEEDAILNAIEEDVDEEVGAGGLKRNAPKVDAFNMKNEQEEGRFDEAGNYVRKAADPDAKHDEWLEGLSKKDIKKAAEAHDRREAELREKRKQEDSILLPDILRVLIQHLGKGETALEALARLGKAQIRTKKIPKWKLKKKLKNNEVSDDKKTDDPNQYQQILAEQKKIKEAVIAITGAADQLLTRGQIDIYEKEREMLMRQYRTEVGTEWDQEQGLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHA3</accession>
    <name>A0A0B1PHA3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ct20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000109">
        <property type="protein sequence ID" value="KHJ36211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHA3"/>
    <dbReference type="STRING" id="52586.A0A0B1PHA3"/>
    <dbReference type="HOGENOM" id="CLU_050564_0_0_1"/>
    <dbReference type="OMA" id="KNDQSIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="35839" checksum="8CBAFCE60C7FF433" modified="2015-03-04" version="1">MPPRKKSRGNLRVDSIPTAYGEETMETSVILETEKPPYDILKDPWTDEQETSLFKGIVKWKPAGIHKHFRMIAISEYLRNHGYDPTIEKHTRIPGIWEKLKTLYNLEHIDYIENNIDHPKSGEKAGIFLEFKLPEEDYDEIQFLRGRRNTSEAPSEITSSPLPDPKFKHSPSPLIKKKRKRKESLVKRRTSSVDETEEAKYSPSTPSFQKQVRRGRPPGRPPTKPVLKQPGRPPGRPVCKQFVKPPGRPPGRPPKKKLESMSRAPSNSIEELGDTEDVEGDSEDEESITLGKEKTMKSNNNDATSKRKSKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV90</accession>
    <name>A0A0B1NV90_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004636">
        <property type="protein sequence ID" value="KHJ30257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV90"/>
    <dbReference type="HOGENOM" id="CLU_028829_1_1_1"/>
    <dbReference type="OMA" id="NWGNDEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="40434" checksum="C09F58C041182FD0" modified="2015-03-04" version="1">MMAAIFEDPRLRHRWNQISQNAESATETAATNIWALQHKYINPCFDSMAFGIKNCIGACCLNCDERVWRRSRGRAEANFDFYDDWDQDDNSRNHGLLGNWGNDELGRLLAGNRSHSNRADGMNQQPRRKRTMSYGTRGRCKSLENDPTVIPSTSALGFLGRLPFKLGGTLRYKPSAADLQDHPGKSSAFLINKKENEILNSDGDYNYKHDKGKGHKRNRGSTMSSDQTSNSFRSRRDLLPSDEEEDAVPLGDEFSLDVERRNTEFGIEEDNRQIMTVRDGYVSRNSSFIISPVPRSTSRSEILLDGKQEVSMDSKSEAIGISSPAMVQTSTTFTLREEDATVTVNKDIKEEKKKAHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWI9</accession>
    <name>A0A0B1NWI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004551">
        <property type="protein sequence ID" value="KHJ30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWI9"/>
    <dbReference type="STRING" id="52586.A0A0B1NWI9"/>
    <dbReference type="HOGENOM" id="CLU_351948_0_0_1"/>
    <dbReference type="OMA" id="NWAVGHD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="850" mass="94893" checksum="A7F3F5FEE1E56672" modified="2015-03-04" version="1">MGTKTKKGFDSCLFDTIDRQILALKTKVLQAGPFLLLVDDQTLYPYTDSNHYRGTPFQPYEVRHLQYLTMMSGGNRGVALPCGDWQNEIESCSPAAIALHIQGSSTSVKGTKPPSKKISIADYKKLRKDGPSKQVTDSCDARSRASSITSEPLSRGPSLEITQEAKIVDGAGILRSQLINQKMEAKRLAIQNLKTSYTNNLTSNRNTPTSVKSIPNTPIVKQMLRSPMRSVIKHPLPPRPQSPKRGVDAKLPSNNFRQQKRLIDNTSPSSCIQAQKKLKNDTASIPSGSQNHNPRKTADLDQPRASPSENSLKPCKASQSSPLYQRDPISNQKRANPRKRAPIKIPDRLSPLPDDLGDLDDLDDIENSDNLGNLDDLDDFAKSVSLSPVYKINSSENSTNIKSGSSSPPFVFPRLLSPDLPLIVEQQLSRLQKKNSDLNSAEARQEVRKQENSTIGRRNTKIGHPLKRASDPTEMNLISKNKFGITKTDISEGVKSYVVKIKYKKRKTKDIERILRMTPKVELEAQRLANTKDKKEETDNSNTPAKNTNSETASKVSKNILLKKRPSELSEILSSPAKRTKMYSDDSAKPKSLSNPLRSPASLKNNYLTTPKKTDIKGINMHKVSSVDSNKTHSPNVSTPVLAEKRSSNNNPSTSNPVFQYDASRFVSEALTLKRKMDSELKTKDLNARKLLSDSETRAGLCTGIECLLAYYSAFSIQRDKRPSDRATSWESTIGLLEFVFRSSEPFLLLNTLAAQLFALVKEELNRSYLDHVSIIKEAPSELLGKIVRNAQSRDRYWMLAARGMSVLQEMGISNSVGPWTCWYDGRDYFLKVLAKYEHIEKLGWKASFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXX1</accession>
    <name>A0A0B1NXX1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nudix family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003106">
        <property type="protein sequence ID" value="KHJ31227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXX1"/>
    <dbReference type="STRING" id="52586.A0A0B1NXX1"/>
    <dbReference type="HOGENOM" id="CLU_034301_0_0_1"/>
    <dbReference type="OMA" id="ELWTYPT"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="431" mass="48820" checksum="3D49EE678E8CC38C" modified="2015-03-04" version="1">MDAFSNGPNSLIKYLSEALQVISQYPCQFVDNSERTTRRASVALIIRIRPHFNHWPAEESFKTGNEESFDLQRYFAMPWVQYGDPEVIFIKRAAREGDRWTSHVALPGGKRDPEDNDDKSVAIRETAEEIGLDLTSPDSIYIGKLPERLILTALGTVPILTLCPFVFLWTKTVLPPLKLQPGEVASAHWVPIRIMLSPSSRTVKYINSSDRIMKRGGPVSKLVLQSILGSIEFSAITLLPSESIHCSSSEEFFPREDLIQLQSKKSYFDRIFNWNTTGKRNQLIKTDPLLLWGLTLGILVDFFHLMPPYNAIELWSYPTFTNYDVRLVINILTRSLRRRNRDSLKIDFSTSLTVIDNETNAVPNKNSVSVGGLVCMAEIIQKSRFNQSHIVGTLLDGYYDMLRRGAIIAASLRVAGVISLAYIIFKGYKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXX6</accession>
    <name>A0A0B1NXX6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003622">
        <property type="protein sequence ID" value="KHJ30788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXX6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXX6"/>
    <dbReference type="HOGENOM" id="CLU_002472_0_0_1"/>
    <dbReference type="OMA" id="INMHAAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="967"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127651" checksum="7FDE304923E2AB98" modified="2015-03-04" version="1">MNKDSSSSRIKSSQQSTISRFFPIKSAKPEARPSSSSISPSLSETLTLHETENRPNLLKDNLKRPCTEIENETSESDDKQPQKFPKRNKYIKTRPPPSSDSSSTIRQDAAPSTTKSSSRTEKYLLRMSEGAVTNGCSSDSEENATIERERQTELHQKWVSKMGKTNLRRNLARFDSIKEIDDEKSDEENDDIMVPKVKKKGAKTGNLTPLEIQFLEIKRKRLDTILIVEVGYKFKLFGEDARIAAKVLSIVCIPGKLRYDEHPSEAHLTRFASASIPVHRLSIHAKRLIQAGHKIGVVRQIETAALKKAGDNRNAPFTRKLVNIYTKGTYIDDIEELQNSFGMHSDRTSSTGYLLCLTESKSNPKNLNTDDKVNIGVLAVQPSTGEIIHDNFDDDFLRQEFETRLMHLAPCEILIVGDLTNTTKKLIKHLSCSSINLFGDRIRVEKIMRGETSAAESFSHVHQFYAQNLKNHNTEDEGQEQILLDKVLNLSENVTICLSAMITHLEEYGLEHVFKLTKYFESFSTRSHMLLSGNTLTSLEIFLNQTDHKEKGSLFWSLDKTQTRFGQRLLRKWVGRPLLDKGQIEERVNAVEELKNGYQTPRVDKIHSLLRNIKCDLERSLIRIYYGKCTRPELFMLLKTFQTIANEYIHIKTPSDANFTSSLLSNAIATLPSINKIIIEFLSKVSAEPALNDDKYAFFHPDHENDLITNHKMGIAAVEQELDAYRSSASSVLGISKRLSYITSAGVEYLFEIHSRDLKSVPASWIKVSGTKFISRFHTPEVIKMLGERNLHKESLSAACDAAFSDFLSQISKHFIPIRDTILALATLDCLYSLSLVALQPGYNKPQISNNTNIDISQGRHPMVEQLLTSTYIANDTHLSTEIGQTRALCITGPNMGGKSSYVRHVALLVIMAQIGSYIPCDYASIGLLDGIYTRMGAYDSLFTRQSTFQVELSETASILKSATNRSLVILDELGRGTSTHDGVAIAASTLEWIVREKECICLFITHYQSLATIARIFETDSALKNVHMKFESKSKASLLTDSNIDREIIDDEEITFLYEIGEGTAYRSYGLNVARLAHVPKIVLETAAKKSHEMELEVKKKSIYKISKLMNNVFKTEDNADLEQLIISMEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY70</accession>
    <name>A0A0B1NY70_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5694</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003028">
        <property type="protein sequence ID" value="KHJ31282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY70"/>
    <dbReference type="STRING" id="52586.A0A0B1NY70"/>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="50757" checksum="BC23D1358AD7EB4E" modified="2015-03-04" version="1">MSDSDGDYMANDLSDDDLGIQSTSNYGTRASASARNVSDGGIAGGGLAAKVDSNEGKTSSRKRAAWEDIQRSWDSVVEGADGSIDSVVEGLREAGMRKRLLRDTTPLQRGIIRHLILVLDLSFAMVEKDLRPTRYLLTLRYASEFVTTYFEQNPISQLGIIGMRDGLAIRISDVSGNPMEHLEKLRNLREKEPQGNPSLQNALDMCRAVLYNTPSHGTREVFIIYGALLSSDPGDIHDTISSIISDRIQVSIVGLAATLAICAEICHRTNAGSDDNYHVALDEQHFREIVMKHTIPPLTRTKKQTQASLLMMGFPSQISTGAKQTLSFCACHNKLTRNGYLCSRCEIKVCSLPSQCPACGMTLILSTHLARSCHHLFPLKNWAEVPWSQAPRSKACFSCLTPFPKTPNDVGAIKNSSSLTLKKDSKGISESGRYACQSCHNVFCIDCDVFSHETTHNCPGCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYI7</accession>
    <name>A0A0B1NYI7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005155">
        <property type="protein sequence ID" value="KHJ30100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYI7"/>
    <dbReference type="STRING" id="52586.A0A0B1NYI7"/>
    <dbReference type="HOGENOM" id="CLU_014148_0_0_1"/>
    <dbReference type="OMA" id="SLPMTKD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="932" mass="108361" checksum="6106B671DCCF33D8" modified="2015-03-04" version="1">MSPRLMLSHQKFSVLRNGGTICKSCLRKLQVSRQRQSIIYRSFSHHVDSRSRNPNGPRVDREIHFYDQNPEGDRVERFVDKEYEDRVEEELLDSDLKQTIEENMPTLKKMYKSSIPNEYQLIDGLKNLEEAGKQFKAFAEKIKLPADLDKLSSEQHGKLREHILENDFFADTYGQDLQKPFKPENKNEIIESGDQESPYEIDPEHIDFSLVQKYLPSDSKDSSSQGNNSNSKSIENIEDKRTARHFPVTSFPKLYQDHISLLQDCLDACFEHEYSQKIGGKSVKVTKEMLRAHLARAYMFARKGLLAAPESIPIKMWEELWQVLEAQTKENLNRLTYMRRLGEDMHELGIPMSNMQLLVYVEALFLDGARRSAVNKWQTFKPQKDDPIWHEYWEIGLRMFAQLGQLDKAFEIAEIYFKDLPEPSHFHALMPLIKACLISKKDRSIQRAWALYLRLKVNLGRKIVMNDYDVLISWFMDAKEPELALAIFRDMMLTGDQLGNRYNSIAVQKISGIIADFKGVKIEQSELEWENTRALSILPAKFNNKLFFGSWIKKLIGDDELNSAKKVIDLMQDHGITPSPMYMNGLIGAWFRRGNEHEFAMADELAWRMINRRLEHMDIRDFRHSLQSPLRPVLNGRSIGDRSALVFPMATVETFSLLVQQYRQRQKKESLSALFDAFVRSRIPPNTKYLNQVILTDTRNHKTSLAFETYRCLTARGVKPDYETFILLWNLMKRCVDPSVGRKIDWQSKNIGTCRLLFAEMIKRKADLCAKHVFPRELYDLIILSFSLKQDNVGTSVALRALQQEFSMFPDENCIRSIVFQLARFGLRNKFGMKPRRLDLSLPMTKDRIGSVMQLFQKMRNQRSTFLLQKGIDPESLSIEDRKEESIIITSEVLRQITIARLFGEKRVNVTCFDVAEQAAKQMGVPHCVVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYS4</accession>
    <name>A0A0B1NYS4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2747</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01003218">
        <property type="protein sequence ID" value="KHJ31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYS4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYS4"/>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="279"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="477" mass="54311" checksum="D7A4BF8A02DC6271" modified="2015-03-04" version="1">MTASTSQDLAIARKDEGNRAFAAHDWPKAIDCYTAAIELDKKATFYSNRAQAHIKLEAYGYAIRDATSAIELDPNLTKAYYRRAIAYTAILKPKDALKDLRFVVRKAPNDKDALLKLTECEKIVKRLAFLAAIEVEDEPSAAEGLDLDSILVDESYDGVRLGSEMTEEFISDMIERFKTGKKLHKKYVYQIVVAVKKILFDEPTMVEIKIEDDVELTICGDTHGQYFDLMELFRINGFPTEKHHYLFNGDFVDRGSWSTEIALLLYAYKWLRPMSFFINRGNHETDDMNRVYGFEGECKAKYNELTFKLFSESFSALPLATLVGKKYLVLHGGLFSDDEVTLDDIRKINRHNQRQPGQSGLMMEILWTDPQTNLGRGPSKRGVGMQFGPDITKTFCEKNGLEAIIRSHEVRMEGYEEEHDGKCITVFSAPKYCDSTENKGAYINIGPDYKLKFCKFDAVPHPDIKPMVGYKDLSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYT8</accession>
    <name>A0A0B1NYT8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004808">
        <property type="protein sequence ID" value="KHJ30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYT8"/>
    <dbReference type="HOGENOM" id="CLU_2293791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="101" mass="11472" checksum="58F08D17B010B8A9" modified="2015-03-04" version="1">MWEMWFSGGDTFMGGIKMVDVLRGPSGKPLRAKWKTPAQIEALRREGKCYRYERRGSDTRIFKVLPPKRPSTMSPMVNLARSPEIENGVCDEDDLAGHSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZD3</accession>
    <name>A0A0B1NZD3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002619">
        <property type="protein sequence ID" value="KHJ31742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZD3"/>
    <dbReference type="HOGENOM" id="CLU_1741923_0_0_1"/>
    <dbReference type="OMA" id="AEPRHKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="150" mass="16686" checksum="8C5C7528606099BD" modified="2015-03-04" version="1">MSRRRNADEELVALPSEGSDEEEEYEDSEDNVQTEGDESEDEEDEDEDLVDEEDEDGEQNPEVKGDEASKKRKLENSNEKTTSVKKSKSVNGNETESNDVESTNESATESSTESAARSDKTEPEIANANDKDKSVETAALERKSKDEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZE4</accession>
    <name>A0A0B1NZE4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003002">
        <property type="protein sequence ID" value="KHJ31313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZE4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZE4"/>
    <dbReference type="HOGENOM" id="CLU_021855_1_2_1"/>
    <dbReference type="OMA" id="HDKCMTI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005110159" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="54395" checksum="C2E5413321ABA87C" modified="2015-03-04" version="1">MIFKCEIASLIILLVFFTEYGLAVAPISIQDQKFVDSVTGNEFKIVGVAYQPGGSSGYNPGSGVDPLSDGDICLRDAALMQQLGVNALRVYNVDPAINHDMCASIFNEVGIYLLIDVNSPLNGESLNRKAPGSSYNVGYLQRTFAVVESFKNYPNTLLFFSGNEVINDVPTAANVPPYLRAVTRDIKNYIAKNSKRKIPVGYSAADVREILVDTFNYLQCSMTGDDTDPSRGDFFALNSYSWCGNSSFTKAGYDVLISDFKESSVPVFFSEYGCNAVSPRVFTEVPALYGPLAAPVLCGGVVYEYSQEPSNYGLVELNSDGSAKLKLDYESLQTQISGLDSKALQGTKARRGNSVSIPKCSSSLIGTSVFYNEFDMLDVPQGVQELIDNGIPNAPSGKLVSVTKTKITNSVQRSNGDLIQGLEIHPIAPSTGDYRNGTKSPGIANPTAGSPVSPIPSGKFTSVGASMPTSSPSSTPDAPKSGAGIFRKNGLIMNLMYGVMPLVAFAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG5</accession>
    <name>A0A0B1NZG5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cytochrome p450 52a12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004277">
        <property type="protein sequence ID" value="KHJ30425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZG5"/>
    <dbReference type="HOGENOM" id="CLU_877716_0_0_1"/>
    <dbReference type="OMA" id="FANTCCK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="317" mass="35745" checksum="2F6D5867A4851079" modified="2015-03-04" version="1">MASGGNYPEVVTNAVLKRVAVGKISRILKTRLAFAQFKVAHGLEDLPFDTIEPRMEELQGSENLSDASSEGDNSCTKTRCAVEVTNNEPLVCSSLHQLMQYNSGYRKRCRHHSFDDSDHHKFSWEKHYSSPPRHHLTPYPSRYHALSSPIMARKHRNFTTDSGPNLPLFANTCCKNGLDYRSAIELERDNQQPLFRVEFQSSPPHTPTCHRYYEHLIRPSPRRRGKISDYNTHQIQCLPLSPSLPISTLTPLPPSTPPPQLPTLPSSLMSSTRGTFIFSGDGVSRTPSYGYDFSDFVNISPSPARLTWPVTPPKVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH3</accession>
    <name>A0A0B1NZH3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005247">
        <property type="protein sequence ID" value="KHJ30081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZH3"/>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_1"/>
    <dbReference type="OMA" id="RNGCCDT"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="135" mass="14592" checksum="0863C57E2A0F9509" modified="2015-03-04" version="1">MTGAKPANCLNALGGQLKKWSSNPVTGYYRNGFCQVGPDDIGNHSVAATLSDPFLDFTASRGNNLRSIGLKAGCKWCLCAARWREAFEFAKSQSLSSNDTINNNPIVPRVNLNATNIKALDVVKLEELRGFADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZU3</accession>
    <name>A0A0B1NZU3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003984">
        <property type="protein sequence ID" value="KHJ30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZU3"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="21666" checksum="E3C7B2F56389E5FA" modified="2015-03-04" version="1">MLADEVERVCSMRPAHLKLYGRNKAEAPHRTWMAFFSKAPSSTFKAFDESGVARKFKKQQPLDFCKRCNSHHPSKNCSRAPSCGNCGSTNDSKEICMAATKCRNCGGPHRSDSRRCLARPTRSGAPTREQLKTYRQAGEREFQALLRAKAAEESAATAENKNKSNNVISSQDTEPDSSIDSSLASSVGNSTDDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZZ7</accession>
    <name>A0A0B1NZZ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002455">
        <property type="protein sequence ID" value="KHJ31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZZ7"/>
    <dbReference type="SMR" id="A0A0B1NZZ7"/>
    <dbReference type="HOGENOM" id="CLU_676515_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080394" evidence="2">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="46628" checksum="9C793794454DC5EA" modified="2015-03-04" version="1">MQLTVYPFVSAFILSSVTASLSVKQEPGFDCGRVFFGKDVIKNAGSLVSRNLKRSTQISFIEQDPFRGRDSNSVGWPIRESGQIFGTSRTRESFYIVVDLSGRVKDVMARLSNDEYTRCSRRNRRRKSLQQDMNNGYRCGQTFFGDDQLRSDADEAISKLGQGLAFPRPYEGNLNMGRELLAWPILSTKKDNTTRWEESPFQVILSRKGNIVDVVAKLKCDDFIRCERAREPTRILRRASESSLLQRRALSHKSYSDYMCGNERFEHEYLVFSRTSATVHFETKKALQPYPKLFSESPCTNIPCKIWPIFPHKANYNLVKVGIHFLMMDRLFNIMGVIQKTQQGSMIACRAVPMSRKPEVKQGELDIVRENKKKEIAKSRLQPTRNSRGEFIVLPGTRPPVLPNKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I9</accession>
    <name>A0A0B1P0I9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004499">
        <property type="protein sequence ID" value="KHJ30309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0I9"/>
    <dbReference type="HOGENOM" id="CLU_2028443_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13981" checksum="7B522F3806276F62" modified="2015-03-04" version="1">MPQQISLSPQQIHHLQQQQILRQAHAQQIAAQQTNQYHHQQEVITPAAQNEIMAYAQRYYQVQKNSIASQNPNVIISEELDKQLRARAQNAARQHYIQALRRQQFVVAQAAQQGGMPPHVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L0</accession>
    <name>A0A0B1P0L0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003619">
        <property type="protein sequence ID" value="KHJ30790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0L0"/>
    <dbReference type="HOGENOM" id="CLU_052835_2_0_1"/>
    <dbReference type="OMA" id="GQIMMKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="249" mass="28580" checksum="1F2FD7047E31DAF5" modified="2015-03-04" version="1">MRVLSTTEITRRAVQAINDIRNSTPVKKKSQKRPVIEHGQHIFIFSHIQKKMVAYSLKRALNNKDTLRHIPFNGKKTVPSALRKDHWLPFATIQFPKGCGPVGLSVFQKLREYRKRHEHEWGEEITKNPENGYFISKKKRGRKICDQVANSVADMAYVLGRLRQQEIVLENEEVPKIDRRIKKYSKRPRESASPYVSKPPPGGIGLVGEGKGLPVQVYWKDIKMAEYAETWSDNVEHGIIGLNNSYAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P196</accession>
    <name>A0A0B1P196_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1156</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003300">
        <property type="protein sequence ID" value="KHJ31065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P196"/>
    <dbReference type="STRING" id="52586.A0A0B1P196"/>
    <dbReference type="HOGENOM" id="CLU_034750_0_0_1"/>
    <dbReference type="OMA" id="CGYCMWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="575" mass="64698" checksum="DA3996ECF951C5E9" modified="2015-03-04" version="1">MTTFKHYTYIQCPCSESRLSQSISLSKRLSTIDISDDEDEHTFDPRAPRSKYSLYPLEYLLYCEDCRQIRCPRCVLDEIVTWYCPNCLFEVPSSTVKSEGNRCTRSCFQCPICIAPLSVTSLEPPSDGLRVDSAPPHGPFILNCAFCMWTTKEIGIKFEKQNGIFAQLSKMNGAGATNITAKNRRKDLHKRQTVLADMKVISVEDEESHVDSSLNLDPESQFSSLKSFYQSQLAELTPSGPLGFGSDFGFGSPGTLSRIMGLYTGGSLIDEISNAKVSVMREARHATEGLQIFEHTQADDKKIINRLFSEGWQSTSSCAQRREITNLNKRFLSDLKPIAYLLRTKRSKRCRACRQILSKPDAKVQSTRYRIRMVASSYVPSINIKPLHPSSQPLLIPFKPFQFLLICKNPLFEKIKVTLAAPSETPSKNCSKTTILCPQFEVGANTDVWDAALQGEDGNKNTMNDIRRGKIELSEGQQQAEAGKIWERGRNWVSVVLEVIPSDCKVDEKSVEETDLRTEDEDLLEIPVFVRVEWETDLAQDESSSINALSKTGGIKETRELAYWCVLGLGRVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B6</accession>
    <name>A0A0B1P1B6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aminodeoxychorismate lyase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003266">
        <property type="protein sequence ID" value="KHJ31085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B6"/>
    <dbReference type="HOGENOM" id="CLU_020844_6_0_1"/>
    <dbReference type="OMA" id="VWLSNGV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="27125" checksum="53DE53ED3DC516F8" modified="2015-03-04" version="1">MSGSNQSEFQLFTSLRYDPSHSFRESSPDLGSGFEVFYMPFYHHKRLLQACKFFGWSKATAKIEDSKEFLSDIEKFVTFQLIEDHDISSPLRLKLIVYKDGKIVYKGEPTPSIDVRNLYPLNLSDLLYTHKIECSSHTYKLYVSRQKIHPGSHTRIKTTFRQPYHLAQGEVGILHKLGDNEVLLTNHSGEIMEGSYTSVYFRRNGQWITPSIEAGGQDGTTRKWALDQGFVIFTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H0</accession>
    <name>A0A0B1P1H0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003669">
        <property type="protein sequence ID" value="KHJ30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H0"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="134" mass="14594" checksum="FD13F9DDC00A6805" modified="2015-03-04" version="1">MAISPALLGKVKPVHSGFALSPCSEEAREKILNAGDGLYLSGAKLEPATNLILVIVPTVPATIRKEQGEVKVRKCMLTNEIERVCSIHPAHLKLYGGNKPGVPHRAWMAYFPTAPNASFRVFDESGIAKKFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H7</accession>
    <name>A0A0B1P1H7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003661">
        <property type="protein sequence ID" value="KHJ30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1H7"/>
    <dbReference type="HOGENOM" id="CLU_2252053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="104" mass="11866" checksum="4925886038CD292C" modified="2015-03-04" version="1">MTSEIPTDYDFKTAGHKITSPEKLFFVIDILFEGEAASWLHSNSVLRAIVNNRQSATDKQVADFKVQLKERFPAKLVNHTEGDLQDDIKIFAQKDSEALTTYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1L5</accession>
    <name>A0A0B1P1L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative karyogamy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002006">
        <property type="protein sequence ID" value="KHJ32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1L5"/>
    <dbReference type="HOGENOM" id="CLU_005577_0_0_1"/>
    <dbReference type="OMA" id="IWIKKAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="963" mass="107506" checksum="3D848E491C35CB5F" modified="2015-03-04" version="1">MHNELNVSPIFKQPDLIDSQRSSALQLYNISEKSADQGQRRIARRPSPGVAARFQALRLGKELIKSDTRSHNEKVGRISENKIKSLNNRHSANSDFSSSPKLQSQVDSSLHVKKRIPDGISTEITVFHPISLEKTKQKDISVAPKALTSMFDSEKSFTESQINKLTTRSVSYVASDSSDTMNTQTGKFESIGPNSSISSKEALPDSNKSDNRVPEDPPGFNPYGLQRSGSIYTISRASFTSQLAQLTSLQLPDAESLSSKISAITTAKIASKALVRAAEQIRSWIIQASKVITGLIDEDDVEWAAAGGREGLSEVDKAITRFEKLIEVYVSAIELLQSRKDVSDIPLEEHNNIISQVDVILAEWSKIKNTLKYVKNSVEIAMEWEELWDTVLGDIGMEINILRKLVFEMEEKRHKSTMRDDEDKIELAELGTIIEEKIHHKADVKPYRSNLSINSPLTQKFPEQLEVPFDDTKLLALFARMQPLRASLDFFPMRLSAFLSRVGTKFPSACKELESRFMEFEMNWKILERDAESLRKELGEDRWVLVFKLAGQQAQKMYGSVERSFTKLQEVVDNDTCIENSVSLCKRYEKKKEFYGPAIEQVLSIIDKGVKNRLTVNGEILRLHWDIKNKWETLKDQMNQLDKTLAKLQVENMNKNPRDFTSKLNNTDHITSGYLHGTPGSSPASSIVITNQKNSLDPATPGKSLTKNTNKLSQVSGKRISSLPVSIARYRRSLSSSFSTIGSSFGSHSSPKQGIMTPTACNISKSSQLSSSDGKPRWNNSTRVQEGSIGHVYKPTSFKTPSPQSNSKQFVKNSNRLSAESKTLSQPPRAQKDEFLTTPDIILSRTSNSRLSFRDRLSERVFTAGNSSQGFAKSSPNQLRSQISLSTLHVGSKCRAQPSRNEMIDNTPTKASRSVTSLGKNPRMSLLPLPKRGKVSAATFSSPRISSVGNTSTRSIEKKPFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P6</accession>
    <name>A0A0B1P1P6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001980">
        <property type="protein sequence ID" value="KHJ32572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1P6"/>
    <dbReference type="HOGENOM" id="CLU_126647_0_0_1"/>
    <dbReference type="OMA" id="AYVYVEC"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="15875" checksum="4B54C97D9B9CEFA1" modified="2015-03-04" version="1">MSFFSSGRRAFTSIYPRMLSTSRVSHSSTFAKITLVGRLGGTPELQATSTGKEILKYSIGTSIGRGENQKTSWFKVTGFLPEGPQRDFIAGLEKGTLLYVEGNVTMNQYQDGEGTTRNGLNIVQQKIEVLASKRREVEEETEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P214</accession>
    <name>A0A0B1P214_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor cys6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001863">
        <property type="protein sequence ID" value="KHJ32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P214"/>
    <dbReference type="HOGENOM" id="CLU_395469_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="697" mass="79944" checksum="700DCB8377464617" modified="2015-03-04" version="1">MVLGNENSKKTRTGKPKSTSFEKTPRKKLPSLLIPKFRRSQIKSAEPFGHSSISDRTVITFTPNSAYDSFELSQKDLYLGLTPSSSSSLSPGESRQTLEPLSGNSFTSPFSPYSNDYGCVAPHRVTTLPRSNNETPYTPQANNFLFCIPSQCHETYSKNQKYSFKSPESKLSYQNSADNCLLYREVDGLKFEIHCTFFTCLLFQIFENSDLYRDEWETKKLSTSLIQVTAGLRQIRDWVAANSQAIKSIPESNNLSLCQNFRETNCWDESDRANIILKNLESHVAIIAELRAKENNVFFWRLSQEAAQRIPQIWSTLDEARKNLVEIVERNQRWLRTTMYLNFVEDRKQFSLPIRSFCSSLVPRLVHPDIYLSLSSKAKERAQILDELSRWNYAFQPLLNASHLTCASQSNFIMASILRMQWLANWIICADENIGADSININKEKLNEFGELFDIADILLKEWLSHQHHKTKVEGMQKCCDTSHQEEYSQFYFGDENNYWFMQYWLFNLPFLSPLITIAWLYRHRPLRTLTSKLLNCCPDQDTNVKEGKNKQNLIIFRKNGLNRQIMAKVLAWLFLIEEESWRLGSTITTTDTNITGTSTKIPIFSSNNYTDCKILEDGSVEHCICSNISSTKLDNGGSDDASTEIKSDYIPDWARARQVSMSYDDGDGKGVKVGCLQAVGYLGSAMGQWRDILIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P219</accession>
    <name>A0A0B1P219_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003387">
        <property type="protein sequence ID" value="KHJ30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P219"/>
    <dbReference type="STRING" id="52586.A0A0B1P219"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="474" mass="53449" checksum="E8AEA23CEFE31EBB" modified="2015-03-04" version="1">MPIMDGKVTKYHTYFEAFSPKDDWGPMPLVITHTSKGQIRIQILKPVVPYKRPVTERPTQKRKENLDTSNAFLPKELADIIATRQRRRRAWHARLLICTTMISSIDSTLADFKEEDEVEEIVAFKTSNYKDKNSKRIVVATPHIFPTPDLNRRKTLEAALPKTPPTNINTWVTVARNSHKKATVVVGEKIQAILSTKASQRQSPTSKIVTLGSDKRHFVRLPQEYEWRKLSPAGLREVLVRKLMISPPLIGRIKSVHPGFALSPHSVEARETILKAGNGLFLIGAKLEFTTSWAPIIIPTVPSTIRKEQGAVDLSSSMLADEIESVYSVRPVHLKLYGRNHTKAPNRTWMIFFSKAPRPLKSNNLLSFANDAMGIIPRKTALEHHLVEMVNCGGSHRSDSCRCLARPTRLSAPTKELMKTYRQAGEREYQAELRARAAEENTATNEHFNLEITSSQCSEVNTNFQNPNASPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P235</accession>
    <name>A0A0B1P235_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001848">
        <property type="protein sequence ID" value="KHJ32737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P235"/>
    <dbReference type="HOGENOM" id="CLU_1225563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="226" mass="25851" checksum="E872EAA5CD81997F" modified="2015-03-04" version="1">MPTFTSTLISRIIWIQHIPKEKRIKQGTGGKLTIRGWDGIFVGYDWKTLTGYLVWDPLKQKARKIRYLIFDERRVKIENSRKILEFENASNDSDSDAEAVIFNNSVNHHHAINFINYPNNSLADHTSLNSSPQTPVSNKQAQGLLDTNTVNENFSNTRSQSRINFQNNITSLSPVEKLTISENVLISSTFPSSQFKNKTAKFMAERALRKEQKLDAEKAWKSAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P253</accession>
    <name>A0A0B1P253_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002171">
        <property type="protein sequence ID" value="KHJ32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P253"/>
    <dbReference type="STRING" id="52586.A0A0B1P253"/>
    <dbReference type="HOGENOM" id="CLU_2135378_0_0_1"/>
    <dbReference type="OMA" id="HFARHIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="113" mass="13094" checksum="22FF9CB5B3E81D9D" modified="2015-03-04" version="1">MLDKVQRAAARVILPVYRTTPSATLYRESGLNPAELTLEHLSRRAIIRTRRLDPFHPLFIKCHRLASRSPVTRFSRIIRTIPPSEQIDPISTPPWEKLSTRHRISVDTLVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P256</accession>
    <name>A0A0B1P256_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01002161">
        <property type="protein sequence ID" value="KHJ32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P256"/>
    <dbReference type="STRING" id="52586.A0A0B1P256"/>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="48"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="396" mass="44308" checksum="E306CC120BC44F21" modified="2015-03-04" version="1">MLRSITTNYRQTQVFRKLKVFRPIMSQRSKSGPFGYIQTKALVFSKYGEPEEVLSLHQSSITPTIPPNSILLKTLASPINPADINQIQGTYPSRPSFTSLLGTTLPSAVAGNEGCFEVTSVGSLVKTVSQGDWVVMKSSCFGTWRTHALAKEDDVLRIDKKGINLIQAATVSVNPCTAYRLLKDFKKLDEGDWWIQNGANSGVGRVAIQLGKLWGLRSINVIRERPDSASTEILRKELLDLGATHVLTEKELMDRNSHDRIMNLNDNGKEIIKLGLNCVGGKATTALVKCLGKDGHLVTYGGMSRRPIELPTGRLIFDDLRFSGFWVSRWAAENPEEKKRMLDEILNLIRIGLLRDVNYQQIKWVWDTDLHVLKDSIRGTLDGFRSGKSIFVFEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P271</accession>
    <name>A0A0B1P271_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative heat shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002139">
        <property type="protein sequence ID" value="KHJ32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P271"/>
    <dbReference type="STRING" id="52586.A0A0B1P271"/>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="702" mass="79735" checksum="1E19A42A61BC836D" modified="2015-03-04" version="1">MSGETFEFQAEISQLLSLIINTVYSNKEIFLRELVSNCSDALDKIRYEALSDANRLESGKDLRIDIIPNKENRTLTIKDTGIGMTKADLVNNLGTIARSGTKQFMEALTAGADISMIGQFGVGFYSAYLVADQVTVVSKHNDDDQYVWESSAGGTFTLTPDTTGEPLGRGTKIILHLKEEQQDYLNEAKIKEVIKKHSEFISYPIYLHVTKETETEVPDEDEEVVKDEESKNAKIEEVDDEEEEKEKKKKTKKVKEVKVEEEELNKQKPIWTRNPSDITAEEYGAFYKSLSNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDLFETKKTKNNIKLYVRRVFITDDATDLIPEWLSFVKGVVDSEDLPLNLSRETLQQNKIMKVIKKNIVKKVLELFQEIAEDKEQFDKFYSAFSKNIKLGIHEDAQNRAALAKLLRFNSTKSGDDQTSLTDYITRMPEHQKNLYYITGESIKAVSKSPFLDALKEKNFEVLFLVDPIDEYAMTQLKEFDGKKLVDITKDFEFEETEEEKKAREAEEKEFESLAKALKNVLGDKVEKVVVSHKLIGSPCAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPRSPIIKELKKKVEADGESDRTVKSITQLLFETSLLVSGFTIEEPAGFAERIHKLVSLGLNVDEETEAEPIAVDEPSSSAEVTTESAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G8</accession>
    <name>A0A0B1P2G8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003558">
        <property type="protein sequence ID" value="KHJ30824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G8"/>
    <dbReference type="HOGENOM" id="CLU_015497_0_0_1"/>
    <dbReference type="OMA" id="RYIFEKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="666" mass="73226" checksum="B802092F5EDA3987" modified="2015-03-04" version="1">MPPFKDEHILIIVPGSQTTLAQLGLPESFTAPSHRFPTRMFRAPDGKSWEPYRIRERPKENTNGDVAMSDTIEEHETELVEFPDLDEDAVWPLKEGRIENLPAFLALLQHIHSTFSPTLHTPILIVSQPSWTAKNHEDITQFVFEKFKTPGLCIIDSAIATSYAYGVANATVIDVGFEKTDITAILDFVISARGTVTESGGEGMTRRLVELLKSKDFTRDMAEQLKKSPICEILPPGIPLPTLENSEATIVGDNLNLKPPELASTGMALLSTEAKIPDAISEKTDDKFVEDEGVLDIAAIVTSGKTQDFLAKKEKEKAERSAARKANKDAEKAEALANANKPLKLPNSRKPRAIFHYEEYVKDVPHSPVLKASEPQLANSNISDEATPDEGVNNNLSSDGVILQEDEATKTDQLNDIRIEEKKKFSEERPNYIRRDIEIGIERFQAADKGYMDAIADTVYRTILSISDISKRQEAWESLIICGSGSKVRGFKEALLGTLNNRYLVTRSSTSAFVSELPSNLGTPRGTPSATGAMTPNNSFSSTFAPSQVTGAGNQIFPTTPMNPMTSHTSSLPMMNTMSNLTATAPATNATQNQPSRSQTPTSIKILNPPTYFPEWKQFDDAIFLGSQVAAKVFFVNDQGQSKAFLSRMEFNEDGPTAIHQVGLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H6</accession>
    <name>A0A0B1P2H6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002807">
        <property type="protein sequence ID" value="KHJ31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2H6"/>
    <dbReference type="HOGENOM" id="CLU_1533711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="3">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="19842" checksum="B990712D3FC3000D" modified="2015-03-04" version="1">MAANFQQQINGSAPMISQQMAQQQQQQRAQQSNFTAQIHQFIYSALQSQQPMLSGWRASAHINERLGLILAIITALRNASQHISTVTNIQKIIEMALKVERDCLMNAPTKEGYKQGIKIKIDQLQEKRSQQTSNFQHVDCKSKWDPKSRSRANYCIIWSTRLFSNSASGSSLHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2J0</accession>
    <name>A0A0B1P2J0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nucleoside transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001748">
        <property type="protein sequence ID" value="KHJ32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2J0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2J0"/>
    <dbReference type="HOGENOM" id="CLU_021611_3_0_1"/>
    <dbReference type="OMA" id="GSPWTTK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="52810" checksum="942B562F2DEFFB79" modified="2015-03-04" version="1">MESPTLIQRLKIPFKQKCEEPEYQPVHTECIGTNSNDEIRRPVLVLPDDDSFPDEKDFSWLQYSVFVLLGISMLWAWNMFLSAAPYFQFRFAENRAILARFQSAIISISCTTNLSCTIILTQLQSKANYPRRIKIGLAIFFVIFSLLSISTKYFLGVSTEGYFAFTLITVFFTSIGTGLCQNGTFAFATSIGRPEYIQAIVTGQGIAGVLPSLAQIVSVLAIPDPDESATAFEKARIIAKGSSSAALSYFITATFISIVTFVTSIPLIRKHSQIPSYNLMDSSRNSQETQKTKRQVVSMRVLYKKLGWLAASIFLCLATSMFFPVFTARIVSVVPEDKAPLILHNTVFIPLGFLCWNMGDLAGRLTTLSPIRKWRIKQRSLFFFVCLRFVFIPLYFLCNLGGHGAKINSDIFYLIIVSFGFGFTNGILSSLCLMNAGKYVDLEEREATGGFMVMNLLAGLTVGSLLSFAVSDVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2J5</accession>
    <name>A0A0B1P2J5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002020">
        <property type="protein sequence ID" value="KHJ32513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2J5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2J5"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OMA" id="AAIWIHK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079673" evidence="4">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="45"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="489" mass="54226" checksum="9FB2C6A40A020483" modified="2015-03-04" version="1">MIISILETLIVVFFLFLELGSYVNTKSLKDRNTTVDSTEISKTLYDVVIVGGGPAGLSALSSLARVRRSALLIDSGKYRNDQTRNSHDVIGSDGMAPSLFRSRAREQIRRYPTVSLQNETVISIVRDDNQSSFITTVSSGQKYKSRKIILATGIIDILPDTPGIKEAWGRGMFWCVWCDSWEHRDQSLGIIASLPTIIGTIYQVTTLNKDIIAFVNGTDTVANRAFLNATSPGWQINLAKARVAIENQTITSIERLQDGSIVRNETSWEEYDIFRVNLQDGTQIERGAFIMNFPKCQRSYLGSKIGVQLVNERIQVNPSNMKAAPGVWAIGDANNDGTTNVLHALYSGKKASVYAHIELATENAVGLRNLKRSVSEVFQDMDNGLENLWTNLKDKSKSVWNMDETGARIGCPTILHHITTTREAVVVPAHVYELHTGSPENRLSITVIETNSAGGNYQPPFIILLGEKLMDDWCHENVENDAWATTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2L8</accession>
    <name>A0A0B1P2L8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative base excision dna repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002760">
        <property type="protein sequence ID" value="KHJ31580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2L8"/>
    <dbReference type="HOGENOM" id="CLU_012862_9_1_1"/>
    <dbReference type="OMA" id="LHVLMVG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="129"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="43902" checksum="923F5532ABF2A301" modified="2015-03-04" version="1">MPPGRKRRHQVIVNKEHDSKKSVKLGVVKELKIEKSDVEHQGTLASKLLPKNPGNDLISRKLSSHVRYQNVTPFPDFVHPTAAECKLAHQILASLHGVRSRPSEIKAPKSRAGCGDSPSVLDALVRTILSQNTNGKNSTRAKLCMDEVYGKCDNWKAIVAGGQSKLQETIKCGGLSANKSRAILGILNQVYEKYNTYSLNHLHKKSNDEAMQELLSFPGVGPKTASCVLLFCLQRESFAVDTHVWRLSGLLGWRPEKATRDETFRHLDQRIPDEDKYGLHILLIAHGKVCPECRAGGKYLNQCLLRKAFPSKNNGEDAIEEELEKVKIEIKKEDEGEGQTLNLKLEIKEDDDIKPNLGNEIKLKMNSNEMDKLATSNIRKKSHKRRRSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T1</accession>
    <name>A0A0B1P2T1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001964">
        <property type="protein sequence ID" value="KHJ32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T1"/>
    <dbReference type="HOGENOM" id="CLU_2706640_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="8323" checksum="3DAB0EAA497570A1" modified="2015-03-04" version="1">MESWKEMCALLQKKMRSLHLQSGLPLKLWPIILDAAINILNITPNKIAPQSSYYAVFGKHPDITHLHPVRSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T9</accession>
    <name>A0A0B1P2T9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003384">
        <property type="protein sequence ID" value="KHJ30979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T9"/>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_1"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="72"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="42841" checksum="0832AE4812B3B98E" modified="2015-03-04" version="1">MSSSNDRSDESSSAKFTAELQDVNGKKSSTILPIVDEDNLPWVEKYRPDTLADLSGHQDILATVSKFVETNRLPHLLFYGPPGTGKTSTILALARQIYGSKNLRQMVLELNASDDRGIDVVREQIKTFASTKQIFNMVPVSSSASSIASYKLIILDEADAMTSTAQMALRRIMEKFTSNTRFCIIANYAHKLSPALLSRCTRFRFSPLKEQDIRVLVDKVIVEEDVKINSDATEALIKLSKGDMRRALNVLQACHASSKPLSSGGTLQTASIDQERDTITETTIYECIASPHPSDINKILHTLLQTSDVLSCLKTINLLKTLHGLALADIITSLSEELMKLDVPPTVMITWIDGLAEIEYRLSGGGSEVIQTGALVGVVRNGAELIIGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P357</accession>
    <name>A0A0B1P357_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 60s ribosomal protein l37 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002977">
        <property type="protein sequence ID" value="KHJ31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P357"/>
    <dbReference type="STRING" id="52586.A0A0B1P357"/>
    <dbReference type="HOGENOM" id="CLU_060160_0_0_1"/>
    <dbReference type="OMA" id="RIMIEEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="68"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="32571" checksum="E7315F88DAB62ADE" modified="2015-03-04" version="1">MSESLDDVIKSLEQIQGEKELTIIKLSEPFSELLTKRLSKERTSDIQSEEFDNPTPATLETDLIHYKELFAKLRFSYLEQVTKEKFIRAIVGDPPLVVEHQENVELEESLAQKKLALKSLKTEVADLVVELEKKGRELYQKYHHIQLQTTELQALPSKLKSLEESIKSLKNLQNVETNPNLLLPLDKTLELIELREKETAELDRQINHLQEAILPRKTNELETLNTELHSLEAKSLSSTLSAEEAKKRKENSINVENDLEERARWWTGVEDMLKGIFSMEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D7</accession>
    <name>A0A0B1P3D7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tpr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003147">
        <property type="protein sequence ID" value="KHJ31189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P3D7"/>
    <dbReference type="HOGENOM" id="CLU_040959_2_1_1"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="45131" checksum="9364BB7F4C3A333B" modified="2015-03-04" version="1">MAKVKPQGKKEKIKDKKKNLGSGYILSKSPKLFVSPKVLLAQAAEFLQLGDPEAALPLAKRALEASNDDSLNSLPALNLCGEIYIELGDIDSARNFFKQAAAIDNEGTISEENGGGPEKFLWLAQISEEGGHDSVYWFEKGAIILRQKMQTLLEQESKTGGGQDQKSDLIEKKRKLAGALCSVIEVYMTDLSWEENAEQKCEALITEATLVAPEYAEPWQTLANIRLSQNRFHDARAALRRSLDLWKDLPSQDPIIPEYPTRVSLARLLMDAGMDTDSLEVLENLVAEDDTSVEVWYLGGWCLYIIGEKQYNNRTECKKEIDEKIDWKETWKSSRQWLKQALILFKQQEYEDERLGDHAREILGILNAQLEKEVDEKENDTDEWSDLDGSEVDEVMVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3G3</accession>
    <name>A0A0B1P3G3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative signal transducer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003115">
        <property type="protein sequence ID" value="KHJ31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P3G3"/>
    <dbReference type="HOGENOM" id="CLU_003029_0_0_1"/>
    <dbReference type="OMA" id="IDLRNPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1295" mass="144919" checksum="01CFF608CB079915" modified="2015-03-04" version="1">MDHSPRKRVTRARVAARAAAAAESNSSKTNNKVMTTSKAGPTTMTTSSATSLSSSSSSSKRKIPNDIIHAKEGDRQIIEVENKITLPKYKTTRSQTRRACTIPEAEIKTKTEPELEATDNIAARKPTRGRPRKILSAESLPPRTLRGRVTRATNIEEKQKPPIKDEKISKHQRQQDTISTTISTITKTSGPKRCAKFEGPGKENINPSSIQNQKKCNVKKEETQATGFRAKPLRKPASTTRSTRGRNKPMQQEGDIKSSTCNINAKELERIDDKSSKAVAKEYSDDELMLVTKSVSRSPLKASPIRPTMNVIHTSDKSEFLTSSLKKIEEPSNSETYEEKIGVIASPARRPPQTPPKQKMKINNQSLGTGSSVLRSSKPTKMFIPELKLETLSISNKPSLLHSPARRFPQPLEYLISGGDCTSNLLPDIVDEYEINKEDSQVPSSVAAPRSVKKIKLRNTINEVNPDNIQLEKVSQLEYPKESNHNLDNMICSEAESVFSGRMSSIVPRDIDPTFAPESLIQETKIIIDASQQDLMESTLTLENLENITNEGIDDNNTPSFPHFESKLNPFMLRRDIDPILEDSDSEDELSSIPAFCRNTFVAPSPYPKIGSVTSRSSLKGQMKPNDCIGFTPLAQKFSHWMTSSPEKKSYAKVRFPENLNTIWDSENIWSGAEVENQNNMELSTKTNSVGNKVEISNQKATQLVPTLMGVDDVQDEERNELEETEIDEEDLELAFEANEMSLLEPSQTDTLENVLLSSEQPPYEIQDNQISSELKMERKNVSNWVENENSSIHKNKPCEVQNNPELQDISNIAIDPRLLALPYPSGDNSFSTPRRTYTERVYHTVCKVPLKPAASETPEMPVNMRCVSASRIPSIQSTSHLNQAGRVSNLSFEEFIQDSVTMTPNKPVIDWSSLGTPARTPRVDLNTSLLNGAVVFVDVYTSEGADASIIFIELLTQMGARCIKSWSWNGNIEEGKIGITHVVYKDGGKRTMERIRDSDGAVICVGVSWVLEATRSCERENKWLDETPYLIDIDVFPRGGNRRRKSMEPRALANLNGTLIPCLNTSRTSQRRCYSVGGANGIGKEEGETPMTSKSHRRDSVQWLRTGVKEEELDEEIHSFEGKENNYFNFTSTLPPLTPSGVVNEKIFYNHTFSDKRSSSLHIGNRVNEGEYIGTPLNQEDEEDDDVPYFLQKEKLQQKTAPVKQRYFDAECQKEIINMDSINYSKKDNNYNRTTGCAFNDNPTSSIAFTTASNFTPSNVAETHDYAFMMRLKAARRKSLQWAPKIGSPLAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P472</accession>
    <name>A0A0B1P472_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001639">
        <property type="protein sequence ID" value="KHJ33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P472"/>
    <dbReference type="STRING" id="52586.A0A0B1P472"/>
    <dbReference type="HOGENOM" id="CLU_038589_1_0_1"/>
    <dbReference type="OMA" id="SMENHSE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39126" checksum="1BE8EE7B297EB20C" modified="2015-03-04" version="1">MTLKRSRSRKSIDATPTKNLHRAPSPVKVILCETSPKISMENHSEKLVKNIGLSLPQKRALIQNLQLEIMERARRLRAQYALQAQGLRTRVEIRVNRIPVAVRRLKMGDLLLKYSEIANEEKICQLKTDLKNPRKIPQHIVSIESALPQRGTKRMSDAISVDQENSNSIEKNSKRTRRYAPRVPASQVLSPRSANSHIVPKSPVRKVSPVKQAIARYISPQKPNPKSIAGVSSGILKSIASKVETRNNSKVTQKLGTESSVVSGRGRRFPPSSNMQKLGRGRTSIVSQASDSSSGTVRRIAPARKAPIKEKPTQAKRGVLGAIKGIGGHKKPSASEKTSETSHTFGGRVLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4W2</accession>
    <name>A0A0B1P4W2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002424">
        <property type="protein sequence ID" value="KHJ31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4W2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4W2"/>
    <dbReference type="HOGENOM" id="CLU_1134268_0_0_1"/>
    <dbReference type="OMA" id="PIMEFAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46148">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46148:SF57">
        <property type="entry name" value="OS12G0499874 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="3">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="245" mass="29064" checksum="FADAA6084BAF04B7" modified="2015-03-04" version="1">MFEFCWNNSKHAATGMAPFYADQGYLPNFQIKNEESGEPITSQTAANHTRKLNEITQKLKSIMTLSNSTMNHYYDTNHKDIEFLVGDWVMLKTDHIRTLRPCKKLTEKFIGPFKVIEKITNQTYRLDLKNLVGKIHDIFHVEKLEKSKKIQDGQQEYGIEWFVNDDEIFKYLIEVIDSRYSKDKIEYQVKYSDKSKEWVDSTEFDKNDIEIQAFHNRNPDKPYPSDRVLDRASRTRQAPIRYDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4X4</accession>
    <name>A0A0B1P4X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002414">
        <property type="protein sequence ID" value="KHJ32001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4X4"/>
    <dbReference type="HOGENOM" id="CLU_1918621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14261" checksum="C9433539A74E1A09" modified="2015-03-04" version="1">MAPPVFTKCAPPPDPPDVGNRVSNSSTTLNKKFDTTISKVCSTPYKAAALYKSGIIEKKLGVEQFSIDLQAEEEVEMNVVTKEPLINDLNTDPFVEYPTPTGASIDNSVKCTPKNSNTNVTNHSVTSLMDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P505</accession>
    <name>A0A0B1P505_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pre-mrna-splicing factor 38b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002098">
        <property type="protein sequence ID" value="KHJ32420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P505"/>
    <dbReference type="STRING" id="52586.A0A0B1P505"/>
    <dbReference type="HOGENOM" id="CLU_010066_0_0_1"/>
    <dbReference type="OMA" id="CETCQAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="855" mass="96850" checksum="415AC07EC000620F" modified="2015-03-04" version="1">MRTEEKKREALRLKEQKNTPPDTPIRSEIPITKTTTQNIRLEEEPVKTAEIAPKDEESKSSSHSIRASKKVADKGEISRSQDIPQVSIEEVRPSSEINTEVNGGTEKVLPVEAIISEANKIPSSHMNVQPIPSAFGFDHNVSAGFPGMPYNSDFNQMQMMMAMQNGMTPNNFNNFSMIGMPGMAMDPMSAQNIFMNGGYGVGMNMGIGLGSFDGGVGAGINGWTGQQSWNLVQDNFNLNAAGMGHGNYGANNSGYVHSTGYNQGNYGRPNHFHDYNNYGSHNFRGRGRGRNGYNRSDFFSHGANEQRYNYHQTNTVQHAQGYISDASSVPKGPKAEVTTIENVDEFGRDIRPASKMEDNSSTKNTENDDSSKKTILGAQNSPAELAISTVPIENEETGSGENPIMPIQTLDAVNAQNSSYNDCNIVRPDFYPGSSRSESFFMQSNFVKPVDVPINAPTGPKAMREGLPNTSLSHLRGRTHSASLAIPLGPDINTNTNNTPGIPEKNGNDRSRSVTRSKKDRSRDRKISRSRDRGHHSRRRKSTSLSEDEREIERRRERRRERRRRREEEEEDADEPIIFPDDGKVNVVEERSQSSTPSDTRHSSHRSRRDEYRDRDRDRDSDRDHRSSSHRRRSRHRSRRNDRERSRSREYRHGHTRYHSEKPEEKHSEINIDPYRTSNEDDDTSCRPSSTNISNLEIKGASSRNKNEDTIIPTGPRERARDRSNERLSSSRREDNRRSTHHHESSRHESSRSSRYKDKVKDNDKSIPIINTKTKDPHELEREARNRERLLKEAQRIAGLTSGVLSRKRNGVDTILDDTSRKLRSKKRRGGAINGEDEEKRLAMMEAEREGARWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P573</accession>
    <name>A0A0B1P573_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001433">
        <property type="protein sequence ID" value="KHJ33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P573"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="21478" checksum="4905B1C146E61487" modified="2015-03-04" version="1">MDTSPESQALSTESRNQPPPIPPILPIPISPSPIASPASPLNLQSLTKNTDGRQILKPVAPSKRPGTERTTLNNSNKINIGNAFLPKELADIVAIRQRRERAWHARLIICTTAISSLESTLANFKDEIEVEEVAAFKAYLQLAIANFAAVDNSPTPPEIPSHSRPSDGGGHGLGKDKITAKKVAVAIPRSITSTESSLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F0</accession>
    <name>A0A0B1P5F0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002519">
        <property type="protein sequence ID" value="KHJ31874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F0"/>
    <dbReference type="HOGENOM" id="CLU_940716_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="296" mass="34315" checksum="96539AA4B501CFA9" modified="2015-03-04" version="1">MLLRSNRIYQTLVNKKSESSSASLNLVETTSEETIYSAIQPISHIEEFFEDDHFKMDFEQASVAQRSSTAIRLEKWQDWPSWFDQLKIWCQRNDIWDDVNPEANGEQPVNNRPTAPSIPIELNNQTRANFQIENAVYTNETRLWKEKDLALKNLDENLKMTVGDQFKQHLMGKITERAKLKSLFENFKPAVASIKADLKAEFELLKSTPYGKPVNDYFYLWQILSIKCKIKEHSIFVTGEEDPSLALHDALQPIHPITAIFRANQINENINAGIEIRLVDEIKAKIDIRKKFSIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L0</accession>
    <name>A0A0B1P5L0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001939">
        <property type="protein sequence ID" value="KHJ32620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L0"/>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="OMA" id="WCIPSVF"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="109" mass="12127" checksum="C17591FF0113ED81" modified="2015-03-04" version="1">MVVHAIHSKAEFDDAINTHQIVVVDAYATWCGPCRIISPVFERLSETKPQAYFVKFDVDEVLDVTKELEIRAMPTFVFFRQGIKGNQITGANPVALENAITMAIELSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P7</accession>
    <name>A0A0B1P5P7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002417">
        <property type="protein sequence ID" value="KHJ31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5P7"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="OMA" id="SFWSHNT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="47"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="604" mass="69197" checksum="2489C3446EAC478F" modified="2015-03-04" version="1">MAPDSRPLSGMQQSELHAVRSSASTPSLRSKEGHFTANRMEKSGGGNIRVVVRVRGFLPREIERGAECLISMNPINQTTTLLLPNEADLANTRSKMRKVMEEKIFTFDNSFWSHNKADSHYAHQSDVYNSLGEEFLDHNFEGYHTCIFAYGQTGSGKSFTMMGTHEEPGLIPRTCEDLFERIEAARQETPNISYHVRVSYFEVYNEHVRDLLTPTQPNQPPYYLKIRESPTEGPYIKNLTDAPVRNIKEIMKYMKMGDGNRTVASTKMNDTSSRSHAVFTIMLKQIHHDMDRDETTERVARIRLVDLAGSERAKATEATGVRLREGSNINKSLTTLGRVIAALADPKQYRPGKRNRDIVPYRDSILTWLLKDSLGGNSKTAMIACIAPSDYDETLSTLRYADQAKRIRTRAIINQDQISAAERDAQIAAMAEEIRLLQLSISDSRRKEKEDIEKEDEVEKWQLKVSDMQRAMEEKDMVQSGKIRSLQTENEALRLHLRLLLEHHKNPIEIHTNSSNNNCNKRPICVSPENGSKDTPNYNKKKVPSLWDEENKTNENYEDEAIDVSLHEEKIHETRLEMQELLSELSIFKRKLSTDKKRFSMLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q1</accession>
    <name>A0A0B1P5Q1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001339">
        <property type="protein sequence ID" value="KHJ33603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="HQAYLLI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="58091" checksum="856A3BA956F0BF60" modified="2015-03-04" version="1">MPAIRPKRTSTMIDIAKDRARSRLKRKGLSQNFINLENMENDLREKGDGTPDIEMIDEHIDKLIAQGLKDSIWAKEDTNESISSTPIEETDSHACKSNQPHQRNIERNKMPEETTRKTSIAPSHPQAHDLRANITQRSENSPEKAPEAHDVPPELRKIIEAEKRRAAKITANLRTCTIAINGVQMVLSTDGADGNKEFSQGLLIYLRAAIAQFMANGPGTTLPVLSSKPTQSLQVKQKEKSALPSNKALPQKLRNTEEKKWASIARKGNQVTPAIPTLSAVPSSTQKHLRADKEKGKHSKPSTGDDRLFLRLAKEHEWRPLALSAIREIICKHLECSLTDILLIRRTATGFALTANDKETRQLLLDKSSMISAQNATIEPASDLVTYHIPNVPVTIQFSNNKVFVTKEMVEAEIKRVTQASPTTVRRHGKTKAGAPYQAWLAHFPRPHAPRVGFRIFDESGLALVYKPRQNILQCKRCLGFHPTRGCSRALKIYWNSLLCKYIFFQSFIIHQAYLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5V5</accession>
    <name>A0A0B1P5V5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001303">
        <property type="protein sequence ID" value="KHJ33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5V5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5V5"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="34193" checksum="CE532385D57B51A5" modified="2015-03-04" version="1">MVHKIKIIQTPSDNLAHAIAGAGGGILSMALTYPLITLSTRAQVESSRANKNFVEAVKLIIRREGGRGLYAGLDSALFGISVTNFVYYYWYEFTRAGFEKAAIASQRASKSLTTVESIIAGAIAGSATVLLTNPIWVINTRITTRKQNHTKNISLDHKFIKIPSTLDTLVALIRDEGPLALFSGVVPALVLVINPILQYTIFEQLKNILTRKGKVTPTLAFLLGAFGKLIATSVTYPYITIKSRMHVAGREGKTEGMGKVMRSIINEEGYQGLFKGIGPKVIQSVLTSAFLFAFKDVLYEQTLKVRRRVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P640</accession>
    <name>A0A0B1P640_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf962 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001007">
        <property type="protein sequence ID" value="KHJ34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P640"/>
    <dbReference type="STRING" id="52586.A0A0B1P640"/>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="OMA" id="IQFIGHY"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="191" mass="21185" checksum="2E255FB8BA1F40D7" modified="2015-03-04" version="1">MSLDLEKQLCFYGAYHHNSVNIAIHITCVPLILAATLTLATNTPTLIPIPEWLTLPNLPPNLGTLTAIFYGIFYILLEPVAGTAMLPLLMGWTAYSNHLTSTIPSLSNKVAIAVEIVAWIAQFLGHGVYEGRAPALMDNLVQALVLAPFFVFMEILFRLGYRPQLQKRVNLAVEKEIQKFKTSGLKKKISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P643</accession>
    <name>A0A0B1P643_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002296">
        <property type="protein sequence ID" value="KHJ32149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P643"/>
    <dbReference type="STRING" id="52586.A0A0B1P643"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="22649" checksum="0C995E35DCA683CD" modified="2015-03-04" version="1">MKNLNRGIKFVPIQLTHAKLFVFVDGSFANNKDLSSQIGFVIVLANESMKNDEFSLYGNLIHWTSVKCKRVTRSVLASELYAMVLGADIANALSTTLNMITNQLCINNIPTIICTGSFSLYECMVKLGTTKEKRLMIDIMAIRQSYERRELSEIRWICGTDNPADAMTKANPSKALEGLINTNSLRIRIQGWVQRHKNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6D4</accession>
    <name>A0A0B1P6D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001232">
        <property type="protein sequence ID" value="KHJ33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6D4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6D4"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25225" checksum="DB3E8A50C69F196B" modified="2015-03-04" version="1">MTDSSTDIKKFNSRLQWQISNQSRGIRCIPVLLESAKLFIFVDASFANNKDFSSQIGVVIVLANECNQKPREFLISGNLIHWTSVKCKRVTRAVLASELYAMVLVVDLAIAISTTLDLITEQLGTPHIPSITCTDSSSLYECLVKLGNTKEKPLMIDTMAIHESYERREISEIRWINGQDNPADAMTKINPTNALRQIVDSHEIRVRVEGWVERTDFNQIKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6E4</accession>
    <name>A0A0B1P6E4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1049</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6E4"/>
    <dbReference type="HOGENOM" id="CLU_014851_0_0_1"/>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="633" mass="71503" checksum="3F43B87800CAE490" modified="2015-03-04" version="1">MREVNFSIPNVNKASVGITTALYDRRALDCTSTLPLINSLNHLAYLTTSSARIRDILTIDGGIERLVCLLKAGRSKDPMDMWKWNLAFQCVVNVGVRGSENVRTRVVEADLIPVIATILDNYIKVFDRCREKAEEALHAKEQRFNGSRSVENQISNKDTSFGSRTVRSQLEFRGIRRHLPPSSHELHMAPTNSLSNTTGSIEITSSGEQNTTLSPSVRASYPGSRHYRLQDTRQHIISPSRHNFQPLLAAIPSMDATDSLSIRPVRDIDRLPSMIVRLHNHSLQPESPTTPLPSNLVHSTNMRSVSTTTHEERSSRRPAIRHQTSLGATEDLNNDSNLSDESGIAEISEDSVTTIQSPVNVNIQEIGMDEDEGILVAVESRLGINPNTVSDTRDVGNFNINHRFTLNVSAVDNTIMHTSPNLGFLPTGQTAINIPPTIQLPNLPRFPIDRSTQCHTLTAMPRDEDVLMSLQLLAYVSKYCNLRPYFQNSHLVPKLKIGAELKLLDMDEMAQFSGFSTAKTKNSMGCSTIEDFEEEEYLLTDDFNIFPLVEKFTIRHHPQDMQYWAGVVMRNLCRKDDSRGGIRQCAYYQCGKWEQYTRQFAKCRRCRRTKYCSKECQKNAWIFHRHWCVAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F4</accession>
    <name>A0A0B1P6F4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative calcium influx-promoting protein ehs1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000976">
        <property type="protein sequence ID" value="KHJ34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F4"/>
    <dbReference type="HOGENOM" id="CLU_018731_0_0_1"/>
    <dbReference type="OMA" id="YYGFLAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="691" mass="76774" checksum="1731AEA91F68C430" modified="2015-03-04" version="1">MSQLMSKVSPLQSKLPASTTILIKAILLCFFFSIFKYSHALEDEELLSLLPTSPTIYNKIDLENENFKSSNSIPFDHEDKNLKKDEQGPNVKPKRQLVMPTLLLNNVMVPFNLERGQLFSFMFTNDSLWNNKSPIISSNPSKLNLFSKKISSASSDPLAKESEDLLFQDKPKAQDALIMGSQDMKKTKKNSARILKNSKKNTLYITVTTCLQPKSVVSSIFTPPPQLQLYISQSQSNKFPGPVRADNPSLNLSQEIVNLVSGYTLRTIDVTGDVYFGVYAANDSNFMGIYSAQIAASIDGPYHNYEDNSDSNLFVADSDTDSVLLYTNPFIHDGTNHTLLREWVTSPPPFVIFVAEASVTRNIIGLENSYCGLEQNVNMVTPNILETGVKSNVATSVTTIGLSNLPRQQFLIDDLKPGTTYIVALAIARNSKEINVVGGGGRVFRSFTFNTLSADNCDLIHSLSFCDQVAYSVPSNPRKFPNRSSLAAFYDNSTEAIFKNFEKVLAQIPCEINPSGQYSLARTCNDCARAYKTWLCAVNIPRCTDILSPNTWLQPRAIDQAFPNGSHLSTAFIEDYKTAAERFSRNVKIDEFISPGPYKEILPCQELCHSLVSSCPASMGFNCPRPGQIGFNTSYGQMPQGNTDNDGRKVDITCNFPGAFYFSLAYNHKPWVPLTQVFFAAFITMMSMVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G2</accession>
    <name>A0A0B1P6G2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001996">
        <property type="protein sequence ID" value="KHJ32541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G2"/>
    <dbReference type="HOGENOM" id="CLU_790356_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="41534" checksum="EE9CB75FE474FDEF" modified="2015-03-04" version="1">MQKAFDFKATPVSSMKAKLLTNYDLEKIFEAVNLFKKENKLEQREINDIIQKDAKKNEDARNLWKFLREKLPNLPKQNVINACRRKFHNFEVRGSWTASQDEELAAAHEQYPGKWKMIGEIMNRFPEDCRDRWRNYLICGSQKKTIYWEFEEEKKLRSIVSEYLDNYRRNHGLTDVNELEVIDWPTISKMMGYTRSRLQCSTKWKVIKERYETGDDDMETSDPLSAAPWRLKKAEKVVSDLVPLQKLLLLRAIRECGVKQVKKVPWVQIGKQNTGLACNKLELRLAFSRLREKVPNCDQMKLQDIVQYLIDAFEKSYPNEPENFHLSGPKVLKRKNMSSAERPIKRIKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L8</accession>
    <name>A0A0B1P6L8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative upf0183 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L8"/>
    <dbReference type="HOGENOM" id="CLU_032056_3_0_1"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="520" mass="58802" checksum="880CCF5DC204857B" modified="2015-03-04" version="1">MSLFSAQVFPGQGLGFIVLGSTLHNVLTRLKAEPRKFPKIDLIFNQSSPLKEPVILGLPDNGLRLRFDGPEQRLRLIEVLDFAKSHLKYKDKDLVRFSALNQSGPIQNGGQSAPSFRHIYNRLLGPTFPGEYVEPITEDKTDVGTYVLSYPGIAFSFPLQKSNWSPEKDFVSLLSSATSQYASSMAIFHGKSWSDCRDSLFTSHIDIRDLFSVSSKDREQLRDEVKLIRIYGEGQIELLRSEGIPAFWINLGLTSPQDLILNLGPPDAIFRKNDHRMSIHKCPVAVSGRIRKNVVRIPDDSTDTDQSSAFTVTDDSESDESASEVVESVTGECFYNYFYQGFDILLSYSVVPSPRPPSKIHDTLKNSCENIIPTDLSNRLVATKLILHGNAPGSYTFNRHRRCRWEIKYLEPKFGQDIIHSESPFHEIEKRLQEEWKSMYRNSEEERAYQRGMVLNRDWGDSLGSSCELLGGREEYINYKKTDPPDADDIKGLGNTNLYGFPGLVFEVMKNGFVSGLTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6X7</accession>
    <name>A0A0B1P6X7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002105">
        <property type="protein sequence ID" value="KHJ32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6X7"/>
    <dbReference type="HOGENOM" id="CLU_1038982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29865" checksum="C95EA4EE654A61FE" modified="2015-03-04" version="1">MILDCSADNDKISSLNDKISSLQSEVNALQTIFYAKGFRTFQTSDAAIPKPRRTRSDPEKFSGAQKDTEKRQTCMSAGRLKYNSVIDKQVNLPNADDYAGWSEMINSIARNLQQQEHIARLQTPPIITRPSDSHVIPTAPDLEDPMPMDLSRMKLSASERTYRLENGLCVTCGEKGHISKDHHRKIDPIPMPKRHNNQPTPRGDDNRYRVPMTNRNNPPSPRNILLIYSTPANPHGILSITVPPSTIATKLSTLLFSSSTSGTTSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P731</accession>
    <name>A0A0B1P731_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative duf647 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002060">
        <property type="protein sequence ID" value="KHJ32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P731"/>
    <dbReference type="STRING" id="52586.A0A0B1P731"/>
    <dbReference type="HOGENOM" id="CLU_015325_5_1_1"/>
    <dbReference type="OMA" id="KWGNLAE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="50"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="469" mass="52639" checksum="7E467F880E473D66" modified="2015-03-04" version="1">MHQENSNHQQIIISEVDLVGNDIAKYIQSNSEKNHRIDVIISSKVKDPYYVRKVIEAFLPVGFPGSVTSDYLSSIAGMIASRAVLEGIGVGDSSVSPTSALLLSVLQESIGRLATILFAHRLGTCIEPEIKMYRLAADIFNDSALIVDCLSPIFPRLWRLSFWCLSSVLRSMCGVAAGSSKASLSAHFATQGNLGELNAKDSSQETVISLLGMLFGSLLLPYISSQKMTWIWLVLLLLVHLGTNYLAVRSICLRTFNRQRTNIFFSEVIENLDHFEPNIVLREIFDNNLKNLVSCLNLPSPRDVSQMEKIFERDGVLRWRDGSVLGYCKIGVPLKSILECFGCSDTKTGSFINFPSQRFQKILHIYRDSEYILSYNKSRSTYLVAIKSHKKNEVIVQLKAWTQALCLAKYGLISNDDEESFLKKLQVTCEFADHLVDSIVSSHNFQMLEWNLEVSAMETLPGTRFVLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P774</accession>
    <name>A0A0B1P774_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002010">
        <property type="protein sequence ID" value="KHJ32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P774"/>
    <dbReference type="STRING" id="52586.A0A0B1P774"/>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="36288" checksum="F83B82D271CEC0D5" modified="2015-03-04" version="1">MRDITQALKVKSEPTLDEIEDKLPPEIKFWSKIFKEDQSSTLPPHRASDIKINLQKDDQRRDKQIPWGPLYNKGWIRASASPGGAPVLFVKKPGGGLRFCVDYLAFNAITGEGQYPLPLIKETLRSISKSTYITKVDVRATFHKLSVREGDEEKNAFLAFQRYVNETLVDYLDVYCTAYLDDIFIYTSESLKDHWQKIQTVFKRLNKAGLKLNPKKCEFAVKTTKYLGFVISLGKGIKVDPEKVEAIKSWVPPTSVKGVRSFIGFANFYRDFIPNFSQIAQPLLKLTKKDHAFIWLDEHQKSFESLKELFLSQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C9</accession>
    <name>A0A0B1P7C9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001970">
        <property type="protein sequence ID" value="KHJ32584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7C9"/>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OMA" id="IKFSRQN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02972">
        <property type="entry name" value="DsbA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26235" checksum="39B029BDB0D200FB" modified="2015-03-04" version="1">MALPPKFAGQLYLLSVPKSPIATPVVRHTLEIYLDYVCPFSARMFNTIYKQLIPKLETDARFAGHLQFIFRQQIQPWHPSSTLVHEAAVAVLRIDGNKFWKFSEVPYSIPFLKTLFSKTALYALFNESKSFYDVPVISETRNQTYARLAAIAEKVDVSKSEVLNLLTVSDKPAEDGSLNIGNGVTNDLKVLIKMARLVGIHVSPTVLFDGVVESSISSSWTVDQWVEWLETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7E6</accession>
    <name>A0A0B1P7E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative pi31 proteasome regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6521</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000782">
        <property type="protein sequence ID" value="KHJ34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7E6"/>
    <dbReference type="HOGENOM" id="CLU_044125_2_0_1"/>
    <dbReference type="OMA" id="EYDINRP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="253"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="37997" checksum="64FDE0F4BD3D7EF1" modified="2015-03-04" version="1">MPVSLTSESILRQMAEALPSHAQHDTSYLSSSYEAIALFCHACMIVSGFRLLGFKEGQNLDECSRLAPRLPQEWNSTFNSHTFFYAHQQSSMQFVIKVDRLGSKAEIRGIGLGDERINRFEVTARDYISLNSLPLRIKISSDDLASIFDLAIVKKLVPSLNKDQEEPRSSTPVIANDERDQSQILQNPLRNPPTEPRIPTAIQPYPIDNFPPAQPQHPFPLDDFPPPGFDDEYDLNRIPQRHPLYPNGSPFNIGYDDLNPQGLGPHDPLRGSFTGGGFSGGISGMHPTFDGPLFGGSEGRSRNARRPEVPEGARYDPIGPGDMPSGNGRPFNPFNRFGDGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7H8</accession>
    <name>A0A0B1P7H8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001761">
        <property type="protein sequence ID" value="KHJ32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7H8"/>
    <dbReference type="HOGENOM" id="CLU_1826727_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="15742" checksum="8B60FCB8E739FD2B" modified="2015-03-04" version="1">MVYKERTIAGVRCNSMFYKQSRVEAVAEKACRDLYARQGLLLETNPLAKYFRSTLKDFPGPASLFPKAAGFKLTMVPITKSFFSPSRIKTFLGIRKKDYIVFANMCTVVGIVREQSKKNFILCEAVNGGSIADSPIEPGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7U6</accession>
    <name>A0A0B1P7U6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001435">
        <property type="protein sequence ID" value="KHJ33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7U6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7U6"/>
    <dbReference type="HOGENOM" id="CLU_003182_10_0_1"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="666"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="815" mass="89642" checksum="10848DA766182D7D" modified="2015-03-04" version="1">MSAHGTNFPPSIGSPGVRSSLHAPAAPSSLRECEVIYYSSDIKRSPISDTKDDNDDSSSLPSPRTDRHSRQDSDPVREDTETSALLPKKPNDLASVVSPSGHYKTGNLSPTTSPKIIGRTWSIRSDQSESDASIRILTGKVDLSDSGTRSRRGYFFSDTKGKNRINHSKKRSTTSYLAEQHGIENTKSMYLNYYIPSLAWIWQYRLAYVKGDLISALTMASFYLPMALSYAANLAHISPINGLYSFVFNPLIYAIFGSSPQMILGPEAPGSLLVGSMVRTLVDQGEILDDDIQSHGIVAGIIISLTGSFILVAGLCRLGFLESVVSRPFLRGFICAIGVVIAVDQLIPELGLADLADLMGDVSHGNTTGKLRFIFQNLNKISAITCSVSGVSFVTIMFFRIAKKRLQRRYPMIVYIPDRFLIVVISALLTWHFRWDMMGLEILGNVKSNSEPIFSVHWPFKTSNMRLIRESMGTAFSIALLGFFESSVAARSLSNEEKNCVLQGITLSPNRELVALGLANLVGGSFCALPAFGGYGRSKVNTSTGGKTPMSSVFLSMIAAISVLYLLPLFHYLPKAVLCSMITVVSWSLIEETPHDVTFFLKIRGFAELGLMAIILLATIFYSLTMGIAIGIGLSILSVIKHSTRSRIKILGRIPGTNRFEFAEDNLDRLEFIEGCLIVKISEPLTFANTGQLKSRLRRLEIYGSTDVHPALPRVRSPEHNRNIIFDIHGVTEIDGSGTQVLEEIVKAYREQGVRIFFCRCPPEGSAVFKKFRRSGIIDLCGGDAYFVQDIDEAIRRTEQNDVDVSNSLVAEGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P835</accession>
    <name>A0A0B1P835_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001613">
        <property type="protein sequence ID" value="KHJ33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P835"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="36561" checksum="BA5AC21EEF422C94" modified="2015-03-04" version="1">MWMTKLWDKPEIENAFLPKELADIIAIRQRRERAWHARLRICTTMISSIDSTLANFKEEVEIEEIVAFKTFLRQAIANFAAADSSSSPPLIPSHTRPNKGNRNSNYKDKDKNLKKVLFATPYIVPTPVLNRKKTQEAALPKNSPTNNNTWVTVARNGHKKARVVVGEKTEAIPSTKASQRQSPTNKTATSGADKRLFVRVPQEHEWRKLSPAGIREVLVRKLSISPTLIGKIKPVHSGFALSPCCVEAREAILNAGNGLFLTGAKLESATNWVPVIIPTVPSTIRKEQGDVEVSSSMLADEIERVCSVRPAHLKLYRRNHPESPLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P888</accession>
    <name>A0A0B1P888_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001357">
        <property type="protein sequence ID" value="KHJ33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P888"/>
    <dbReference type="STRING" id="52586.A0A0B1P888"/>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_1"/>
    <dbReference type="OMA" id="CWSVMPA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="568" mass="63294" checksum="3B0E5FC823756018" modified="2015-03-04" version="1">MAMKDAKKTAIVVGAGVGGIASAARLAKAGYAVTVLEKNDFTGGRCSLIHNDGFRFDQGPSLLLLPQLFHETFNDLDTSLAAEDVTLFKCEPNYHIWFGDGKNFKLSSDMAVMKQEIEAFEGKDGFERYLSWLQEAHRHYEISVREVLHKNFSSIFNMLRPNFFVNLFDLHPFESIYSRASRYFLTDRLRRVFTFGSMYMGMSPMAAPGTYSLLQYTELAEGIWYPKGGFHAIVGALERICTRLGVEIRLSSPVSQILTTGDGKAVTGVELSSGERLYSDLVVVNADLVYAYSNLFPTQPSSFAKSLEKRESSCSSLSFYWSLSRQIPELQTHNIFLADEYHESFNAIFDRHSIPEEPSFYVNVPSRIDPTAAPPGKDSIVVLVPVGHLLESRNPKSNVNTSEQDWNTITSLARSKILKTIQERTGCAELAPLIINESVNTPITWKAIFNLSKGSILGLSHSFLNVLSFRPKTKHPQIKGVYFVGASTHPGTGVPIVLAGAKITTEQILADRKVEVPWGKKTQIHSDKNMAKSDLDRLKKNTLLTSNLGILSSVLLIILLWLSMNMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P893</accession>
    <name>A0A0B1P893_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001352">
        <property type="protein sequence ID" value="KHJ33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P893"/>
    <dbReference type="STRING" id="52586.A0A0B1P893"/>
    <dbReference type="HOGENOM" id="CLU_485016_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="63598" checksum="9829FF7DD769A591" modified="2015-03-04" version="1">MNQMNGSQLPQDRRNALNPPPVCFNCGIPGHFVVACPHPSREVPAGISVLYNQVPDSHNWQVQQRPRPYRQQQSYYPNQHCGANPGALSPSIYNASSSPALSYQLTNHPNHYLASQQNIPNYFSSSNHTSQNLHHGSLSYQAPTPNHPYSNLGSTYQGTSPFVHQSAHQSQWSFSPPGSSDHESWLKAPFSSHQKKFSAAKNLKRQQSYRSVTTCENICGSPSSTGKKNHKYSSEISHNFSPETSRTSYPNKRFKFQKLNLCSDEIANSSEDYIHASSHHSISAQNVIPKAQTHTDDPESQPTKFSVQISKKIKKVSQNKIDQDEELWEWEFNAIFKEPSEVETVELAQPLAASFKSTPVPLTQPWSLLLPSISRYARKENAKEFTRSIRCSPQWSYLQEDPTFADIKLDSPLISLDEILDWIAVRREVGFNFEETSKSINSKNYSLMREKKDESEKKNQSEVDHQIKVDAQCIIEEASPKKRKFESLDAPCDHEYLKVNPVQSRLSQKNSSTEISLDNKHLKNIQESNTAFSVSDTSKNKNHACEVSIFAAYRSVSYNFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A4</accession>
    <name>A0A0B1P8A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A4"/>
    <dbReference type="HOGENOM" id="CLU_094654_0_0_1"/>
    <dbReference type="OMA" id="CECEANG"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="30510" checksum="F1C9A340C98DCA79" modified="2015-03-04" version="1">MELENRPLIDPDCSICGAPGFNLCRCEGLELEAAVNRAQELMMANCLEQIREWVKFRARNFILDYFKRLSNQHEREYNEHILEIESRSTHYYNSAQYLNEVDLEGARLKHNINEAWKASIQRYPEVLQYFYTLVDISRPDDSDACVINPPIYLNDEARPRIPMNARTRDGENISDLRGENDREYDHKLRRRRRRSEKHQIQEREENILRSERARDTYDDYRQSNHSRSKKYGHDRGKHGRPHSDAYEDQSYYSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8B0</accession>
    <name>A0A0B1P8B0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001763">
        <property type="protein sequence ID" value="KHJ32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8B0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8B0"/>
    <dbReference type="HOGENOM" id="CLU_320339_0_0_1"/>
    <dbReference type="OMA" id="MRPQMGS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812:SF9">
        <property type="entry name" value="MYB-LIKE PROTEIN X ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812">
        <property type="entry name" value="NEUROFILAMENT TRIPLET M PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="906" mass="103312" checksum="255A1AEE4052B0D9" modified="2015-03-04" version="1">MATWGSYLTSFVRKNNEEPAKDPSLIVASSTTEVNQPLVESVTAKSLPTSKIAVPAESSPGVQGVKKLYDLNPSPDSKLEPTPPKFNSNAARVAKMFGYGSPVAPVSSEKLQNVSIPTTVVSVTPAKSVAPENPVNLQTPPQLSTPVIPPILPAKQSAEETPRSLLGPAVAVTTPETSKNVAIKPSGLYAWAFGSSTKSKEPTKEIKDTKSPSPQLKSKNQEIVTPSNSVKKPSEFQTSLENIKSYNGGMLPSANLEATSLEPTSISTGLGSSSILSSINSSRFDARVSAQSKLITSQQNVSAFNSSRPGSVASSASVSTRYNQSSSLSSPISRRDSIFSHFSTSSLRPFDNSLTSIEEKVARELRLQAEKEHRMKLMAFTKSIEEMRIEREKMEFEKKKMMDEKAAFERDEYQLKDKEEQMRIFVADFELEKEREIREQEKLRLEQEEEKRRQLEEEKRRQLEEEKRRQEEEEEKIRQQEALRIENEEKIRKQIEDREQRELQQKMFLEKKRAAEQDEKKEEKRNNSTIPKYNLDTESDFKNLKDKEDISKQRSYQEDDDDYSIYDDYYDEKSNLEEDSLDFQGQLESKIQNNKAKQDELEEDEYEKELEMQRFLQESRQREEEEERRRYAEDQAKRFRQQPPIQAGSPEIVALEQKSPQINLPQMGLPQMGSPQMRPQMGSPQMRPQMGSPQMRPQMGSPQMRPQMGSPQMRPQMGPPQMRPQMGSPQMRSQMGPPQMRPQMGSPQMRPQMGSPQMRPQMGPPQMRSQMNPQQAGPRMGPQQMRPQMGSPQVRPVQNGQQVEQGRMLPPRQQRSEERDFRRQENEESEDEEANREEEIRKAEIKMRKAFAEMSLQKSMSQMPVQDFEPQPRTPPRKPNLTYITPAGGLPSGPRKGNRGLPARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8F9</accession>
    <name>A0A0B1P8F9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative importin beta-3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8F9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8F9"/>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="360"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122444" checksum="54F5C721B1AF19C4" modified="2015-03-04" version="1">MSLLSPEAHNELTQLLDAIQSPDNSRRSIAEAHLTNNWTLLKPEMLLIGLVEQIQGSNDPAKRSFAAVIFRRIASKTRKLQNNQSVETFISLPTEQGHIIRQKLLEALSSETETSTRNKIGDAVAEVARQYSDDKLQWPEILGVLFTLSMSQVMGQREIAYRIFSTTPRIIEKQHEDTVLSAFTKGFKDDDVTVRLAAMEAFASFFRSLNKKSKQKYYELISEVLNILPPIKEKQESEELSRALLSLIDLAEAAPKMFRPLFHNLVVFSVSVIQDKELSDQARQNALELMATFADFAPSMVKKDPTYVNDMITQCLSFMTDIGIDDDDAVEWSNSEDMDPEESDLNHVAGEQCMDRMANKLGGATLLAPTFSWLPRMMNSNSWRDRHAALMAISAISEGCRDLMIGELSQVLDLVIPALHHPHPRVRWSGCNALGQMSTDFAGTMQQKYHSVVLPAIIPVLNSPEPRVQAHAAAALVNFCEEAEKSILEPYLDDLLTHLFVLLQSQKRYVQEQALSTIATIADSAEAAFSKYYVTLMPLLFQVLQQENSVEIRLLRAKAMECATLIALAVGKERLGADTLNLVHLLANIQQSITDADDPQAQYLMHCWGRMCRVMGQDFVPFLSNVMPPLLDLASAKADIQLLDDDERLEAAQQEEGWELVPIKGQVIGIKTSTLDDKHMAIELLVVYAQVLEAAFAPYVSDIMERVALPGLVFFFHDPVRAVSAKLVPQLLSSYKKHFGHPSIETQALWNATIEKLLESLNAEPAIDTLAEMYQCFYESVEVMGKNCLSQQNMETFINSATSALEDYKDRVANRAEEREEANQEDGDEEPEEVLLAIEDDQNLLSDMNKAFHCIFKNHGTEFLPSWERLHGTYEQFLKSQDPTQRQWGICIMDDVLEFCGEESFKYSNYIIEPLIAGCRDAAPANRQAAAYGIGVAAHKGGPQWSAFLGPAVELLFHVTQFPNARSEENVYATENACAAIAKILHYQPSSVQDQQQIITQWIDTLPVINDEEAAPYAYAYLAELIDQHNIAVISQAGKIFLYIAKAIEAETLQHSVAARIATVAKTLLQVAGLGVSQVLQQLPPETQQSIQGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8J5</accession>
    <name>A0A0B1P8J5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative c2h2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000811">
        <property type="protein sequence ID" value="KHJ34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8J5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8J5"/>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="OMA" id="PMRSTFA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="342" mass="37885" checksum="7844ADA67DBFBFF2" modified="2015-03-04" version="1">MTIAIENQQRFNGGINYDLPYMNTPHFSNPWTSTSSATSHNLYAPPHQNINSNINLDVKPPQPRRLPGNLPQGSYSNVHAPSPPTNNSIDNYNSHHYLNTRQELLSNNRSVSNGYEPHYSTAPSPIQNTFPANQSPYEPLPFVTSTIRPTYSLHHPDNSRRISQPNISSDNRTIHENIDASRSIIAMNSNSTSQNSYGHPVRIRDSGSVDSSIGEYTCSALPRNNPELGTGSSRTLPRPPAILGGGTSPAPPAPQSMMSQFSSKITSNTLKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFVCNMGGCGRQFSVVSNLRRHQKVHKNETRSEAGSEEHQSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N3</accession>
    <name>A0A0B1P8N3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000553">
        <property type="protein sequence ID" value="KHJ35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N3"/>
    <dbReference type="HOGENOM" id="CLU_024519_1_0_1"/>
    <dbReference type="OMA" id="WRYELDP"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59479" checksum="2204E586AB66F806" modified="2015-03-04" version="1">MVSIPDSTSSVVSHPSRQSYRPRSQVGCAHKVSRNEFPVFGDTGDVEILVNTGGKTNRYLLHRIILAQCSKFFLASTSNEWRKAPGYTVGCEEKTNEKEEKNYGKRWTYELDMGDGVHDVPVLVQRKLNRFSTSSEACPPPVRNKPGHTSHQSFVGSESVVSHQSLSSSSYLHREAAGLRQAYHNLFLTFYNYPPDLDSCCISRAYHQCKALLRLADLYDALPVVGPRIEHHLLRFQSALWRHIAKYPASYLYLGYFTASHSIFQEAFVHVLGRWPEIEYYVRERLPPCVTELMQDKYRDLKELVRGVEIGLWSLTLYTAEGKRVTPQNSYLDWLVMSFYREWLSEHCFTLSSLGSTQSVRNSYASKLGKASIEADSKIRTQSDCNVAVQKGELQEPSRIIHDQSSPRTSQILSFSKSQDNRVLHTILPSILLDIGRSSPSAPAYLGHEECKRFLKLSEVLYSRNNLRNFEQRLEELRALARQVVMPVMESQLNNGRHMEEYLVCIGIKSGEWPWEKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8W7</accession>
    <name>A0A0B1P8W7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exportin 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001616">
        <property type="protein sequence ID" value="KHJ33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8W7"/>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="966" mass="109698" checksum="FB9DC987F5595CE9" modified="2015-03-04" version="1">MSSTTDSHEALYPVLTAMKTMRDGTREHKIAAHQFLESFQKSTEAWQLTIGILNSQAEAEVKLFAATTLRGKITYDLNQISTETLPSLRDQILGLLKTHTATVRPIRVQLCVCLAILAIQMISWQNVLPTIVSSLGNDENGHSCILDFLKVLPEEVTEGRKINLTEDELQKRTTELLTNNIAPVAQLLVNYAQSSVEAAQNPHLINVITSWLREIPISDVVNSPLLNLVFNALRNPAAFEAAADCLCAIFRETRDVDECLPTIQILLPKLIGLRPQIKEAEEQEDCEVFKGLTRIFTEAGEAWVVLIAREPSVFRPIVEAILECCGRDHERDAIAFTFVFWYELKLYLILERYIEARMHYLDIYSQLFDIMLKQLEYPSTDVNDQNDLFDGDRDAEEKFREFRHQMGDVLKDCCEVMGVTECLTKVLGKLKVWMSTYGGQITKLSIPCWQQLEAPLFSMRAMGRMVDKEENIVLPQIMPILVQLPLHDKLRFATIMVLGRYTEWTSNHPELLESQFSYIVSSFQTDSKEIIRAAAMSLKFFCSDCKYLLSDQVLQLQQFYDQTLPKLPSVSQEELTEGVASVVAVQPAEQILALLQLYCGPLMTKLMSLANQATDEIGKLAIADHLQLITLFIQNVKPHVALGQENPAVKYCQEIFPILSTILKTFINFTPICERICRNWRYMVISYRTAIAPLLPLMANELANGFSISKQGCFLWTTSAILREFSEDRENVDSHTIDAIYQFFEAQSTNMLQMMSDLPPRDLPDVIEDFYRLLGDALLYYPQRLIQSSLFSPIFQAAVASLALEQRDPLNAALHYIRDVIAYGGDNPYSSSNTMVAPYSKETITSLIIANGEQLVKQVLAGMMINFPDDCFSDASGTLLGLFQILPQQTTDWVDKSIRMLSPETVSEAEVNRLISNIREKISLGPDEIRKVRSQLQDFTNSYRRRHIAPRDGLRFFEAERFHFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P904</accession>
    <name>A0A0B1P904_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000732">
        <property type="protein sequence ID" value="KHJ34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P904"/>
    <dbReference type="STRING" id="52586.A0A0B1P904"/>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OMA" id="HFTTGEP"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080547" evidence="4">
        <location>
            <begin position="23"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="49"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="43708" checksum="CD31EE1A5AB4C645" modified="2015-03-04" version="1">MSQSVVTILTCILCLCLHLCLCVVVPANPLVLQNSNHREPTAGPLKPQFDVVIVGGGPAGLSALCSLARVRHEVLLIDSGEYRNSPSRRVRDTIGSDDIPPALFRYRARQKAAQFTSATLQNGTVESIVRGRDNSTFTTTLSNGQSYTSRKIILATGLRDVLPNVPGIEDAWGRGMYWCAWCDGWEHRDQSLGIITTLPKLVQSVIHVSTLNKDIIAFVNGTDTPANRQLLAASAPGWEKYLKQAGVKIENRKISGFERLQDGSIFRNETSSQDYDRFRVYLEDGSQILRSAFLASFPKVQRSYAGAKIGVQLVDEKIYVESADMKAAPGVWAVGDANSDNSTNVPHALYSGKKAAVSAHFELGSEGLSEPLIAITKRSESDLLRDMENGLEEIWDSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P968</accession>
    <name>A0A0B1P968_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01001173">
        <property type="protein sequence ID" value="KHJ33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P968"/>
    <dbReference type="STRING" id="52586.A0A0B1P968"/>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="OMA" id="ICGVFEE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="33043" checksum="0E732DDEB0D9361B" modified="2015-03-04" version="1">MGLSVAKQLAKKGANLFIVARNVEKLERAIEQIKIVAISNTQNFQYFCADVSRAGVALEVVKEAYRWNNDQLLDIVWCIAGSAHPGFFIDVPIQEMRYQMDINFWSCVEMAQAILPQWLSTAAIEKKKTRHLIFTSSVVAFFPVVGYASYAPSKAAIKSLSDTLAQELILYTDEVKVHTVFPGTIQSPGLDRENESKPKITHILEESDPIQTPDIVAAKAITGLEKGEYLVTVGWLGDAMRGCAWGGSRRNNWVGDTIVTWITSLVWPFIYNDLNGKVRRYRKSNGHPSTYKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P999</accession>
    <name>A0A0B1P999_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g4626</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000699">
        <property type="protein sequence ID" value="KHJ34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P999"/>
    <dbReference type="STRING" id="52586.A0A0B1P999"/>
    <dbReference type="HOGENOM" id="CLU_017787_1_1_1"/>
    <dbReference type="OMA" id="KFERVDM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030869">
        <property type="term" value="C:RENT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140013">
        <property type="term" value="P:meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051229">
        <property type="term" value="P:meiotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="234"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="444"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="572"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="617" mass="69458" checksum="1655BBD04DEDB964" modified="2015-03-04" version="1">MTPSIKFGQVIEFIPNRLYLASYSSPPSVDTLFPYPESMNSRRSPSKKSSRAADGTPIRSSWKRIPCYFTIDDSLPYNAFHHDFGPLHIGHLYRFAVQFHDILAAPENRDRPVVFWSKANARSRANAACILASYMVLIQSWAPHLALAPITQVDPPFMPFRDAGYSQADYEITVQDVVYGVWRAKEQGFCALPQFDLEEYERFERVDQGDFNWLTPDFIAFASPQHNPVSEISKSSPSYENLPRTVEAVDSHKSLPGPFKNILKHFATRNIGLVVRLNSELYSSSYFTALGIDHLDMIFDDGTCPPLKTVRKFISLAHDMITTKKKGVAVHCKAGLGRTGCLIGAYLIYRYGFTANEIIAYMRFIRPGMVVGPQQHWLHLNQGIFREWWIEEQFEIKMKDRIANIIPSTPKITSKSVKLNTQVVTPPNGNSRSPLREVDNDRRNSIGVQEDCLPAPTPGQPRKTSRSVDFHHPYKRKTSSYTSTNEDKIIQREAEIISIHRSSIDNTDEDEIQFRMRSSRKTSGSPSGRSMSQTTTTIYTSIHNDSCNDIENLGTKPRSKATSSIKSGSGSIILNKVRSSPKRSNDILKGSMESAGIRKTSGKLNTVGTTTRKVPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA88</accession>
    <name>A0A0B1PA88_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000322">
        <property type="protein sequence ID" value="KHJ35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA88"/>
    <dbReference type="HOGENOM" id="CLU_2172929_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="110" mass="12128" checksum="D385226887E2E4F9" modified="2015-03-04" version="1">MASARIRKLDIYHPARLRAMEKTNEARFRLHLRTTTRGRPGAALIHDSRIQRASKLLPESEPPPKLARPGLVSTQPKKIDKGTAASLRKDWLAQLPSSVLCAYSDGSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAA9</accession>
    <name>A0A0B1PAA9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000976">
        <property type="protein sequence ID" value="KHJ34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAA9"/>
    <dbReference type="HOGENOM" id="CLU_2759701_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="70" mass="7253" checksum="957694F1A7C074CE" modified="2015-03-04" version="1">MRMKMIHAIPAVVMFAVLVVVVVNVVVAVVAVPIVAPTPVAPGGTEDDVEVGRIDVIEVEAIAALVLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAH6</accession>
    <name>A0A0B1PAH6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAH6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAH6"/>
    <dbReference type="HOGENOM" id="CLU_050460_0_0_1"/>
    <dbReference type="OMA" id="ANFRKKP"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="37243" checksum="C7F46E35192DE49E" modified="2015-03-04" version="1">MTTDAVEKIQEPTVVFKKRGRSKYRKQIAKISSSDSDSDNGSDEEIDIKVKRHKRNHAAITASIKSTPASTIDVEPTRYAAERNETIKSSNDATKSSNWFDEHEVNNLSEKNLLGSTRNKVTNESEKLYKGLANQTKFIVRNENAPKRVVGPIKAPANLRTITVTDFAPDVCKDYKQTGFCGFGDSCKYLHAREDYKHGWQLDKEWENVTKDKKLKAGTTIASINRKVDDEESEDDETMLENIPFACILCKEKYQNPVVTKCRHYFCESCALKRYKKYQSCAACGSSTGGVFNIAKNLKKLLDRKRERAFKKREKALQNGEDVSDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAJ3</accession>
    <name>A0A0B1PAJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetratricopeptide repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAJ3"/>
    <dbReference type="HOGENOM" id="CLU_058463_1_0_1"/>
    <dbReference type="OMA" id="KSAIDDC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="273" mass="30515" checksum="B50E80F37BFB8DE6" modified="2015-03-04" version="1">MASKPECKQPDEEECDKHTAAKDKLRFSAAEEESLLIESNKHKTSANELFAKSEYDDAIDAYTEALSICPNYLDYEVAVLNSNIAACYLKLKKWKEATSSATSALERLQKMMENIDKEHENVAEGKLESETNEQYETIISAGAAKAQDTSNIGKRKTDIERIKTKAFMRRARANCEIGSWSALQSALDDYNILSKMINLSPADRRFVQRQLDLLPSQTKAAQDKEIGDLMGQLKNIGNGILKPFGLSTDNFQLQKDEKTGSYSMNFNQNSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAU9</accession>
    <name>A0A0B1PAU9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative duf498 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000424">
        <property type="protein sequence ID" value="KHJ35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAU9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAU9"/>
    <dbReference type="HOGENOM" id="CLU_074390_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="28010" checksum="F499EEAC373E1857" modified="2015-03-04" version="1">MTSRSCQVFRSTIQNYVYQLFPLHRKLNHRYLSFQTLQRSTPCRHIRGSLLSHSQNSIIVDWNSKPFKTNSQYSSKVHKYNLSPQSNEDTRTDFGSLDILGNTPVPSTSIDACLWDGFHLNSGIKITGGMGVLLVGGKAFSWQPWIARKDNLKKLLNEKGQWEVEDETWGIFETTWPRPDLLILGLGKEMRPLSSKTSKKIHGLGIRLEIQDTRNAAAQFNLLATERGIQNIAAALIPIGWKEEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBD8</accession>
    <name>A0A0B1PBD8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000979">
        <property type="protein sequence ID" value="KHJ34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBD8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBD8"/>
    <dbReference type="HOGENOM" id="CLU_021597_2_0_1"/>
    <dbReference type="OMA" id="GDRMFCH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="54716" checksum="B4C2BC9FEF17E875" modified="2015-03-04" version="1">MADHSSGNSRITHLDATGPRSVVYCHQCEQEWWEDEYGLECPYCEGNITEIVTPGADDPRRISDPVPSDLHNAHSRTWNGYSSSSDSADSEEIHLDGLGGNTSIIFRTFRSSTPQNFTPESRESRDGAGNETSAPGRSGPETLFSEPNIQTRTFRIGGNGSGNSFVGGRIIVTNSSTNSGNFLRPRNANEPQSDGTPQVDDLVTIISSILAPTTSDGATGFDLGDENEQQTGLSTSQIDSFGFQTGPAGFHTLLSTMFNPRNARFGDAVYSQEALDQILTTLMEQSTASNAPGPAPPEAIAALPRKKLDAQLLGNEAKGECSICMDEVKLGDEVIVLPCKHWFDEACVTAWLKEHNTCPICRKGINEESSSSDSSRSQRSQTYSPESQNLNRYQRRGPTRTLFLRGEPRNRNEDRYNSSRNNDGGSQQQRSPRPHEEDSMATIPGSFPTDNTENRSSERSRLTGRSSNTRNTGNVNRSSAFHRIRGFHERLNNNLRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY4</accession>
    <name>A0A0B1PBY4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mitochondrial ribosomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000855">
        <property type="protein sequence ID" value="KHJ34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY4"/>
    <dbReference type="HOGENOM" id="CLU_040318_4_2_1"/>
    <dbReference type="OMA" id="CMRQSRQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="355" mass="39214" checksum="8D05FB5DA956F05D" modified="2015-03-04" version="1">MPVKIVAQRGRSALLKPVSRCCARLLSSEHSAINPSLSYECTSGSSPPEAMSSPTSEILNEAPSIINRWIPANMKRKGPSDYIVLKTNAIKATIQRTTAKLGATPELRYHPKQTLWNPPKPEDVTLEMLMAAQTHFGHHSSLWNPMNQRYIYGIRHGIHIFSLETIAAHLRRAAKVVEDVCYRGGIVLFVGTKKGHAAALVRAAQLAKSYFLFERWQPGTITNGDQILKMCRIKAVDPLDKEIEGFEDKLETWSALKPDLVVCLNPMENYIMLHECRSNNIPTIGVIDTNADPTWVTYTIPGNDDSLRASQLIAGVLGRAGEAGQSRRLADAKNGLITWKTNPRLGNPKAMGAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC57</accession>
    <name>A0A0B1PC57_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative g-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000250">
        <property type="protein sequence ID" value="KHJ35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC57"/>
    <dbReference type="STRING" id="52586.A0A0B1PC57"/>
    <dbReference type="HOGENOM" id="CLU_024810_3_1_1"/>
    <dbReference type="OMA" id="NDIKCTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080603" evidence="6">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="448" mass="50434" checksum="64C9FBFDF81EBA9E" modified="2015-03-04" version="1">MLRFVLIMMIMSMQVMSSFGNSSELMAAVDKHYTNLSVIERIGSVLSLMGTIFIVVTFLTSSSFHKPINRLVFYAAIGNFASNIATLISRSAVVKGHFGSTLCQTQAFLIQMFMPADVLWSFAMSLNVYFTFYWHYNATDLKELELYYIMVCYGLPFIPALTFLFVSTPEKGHVYGDATLWCWIAPGWDIFRIVTFYGVVWVAILISLSIYVRAGKDIWIKRQQLRNNSAPPPNPIIIVKDPFRSEPIGQVMVSHTIETRSEHFTAATNDIKCTHTMAPGSLSQSSTDYKIEISANPVLRDPVSSTSIMEDLNSIPVRRYAAMEANRAIWSYTKVSVLFFLAMMITWIPSSANRVYSLMYKGRVNYALHLVSAFVLPLQGLWNAIIYSATSFEACRHDWNRIRSGKPLRSGLRAFISGRGNYFANGSTKPLYYQESDSVTELPSSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH1</accession>
    <name>A0A0B1PCH1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000942">
        <property type="protein sequence ID" value="KHJ34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCH1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCH1"/>
    <dbReference type="HOGENOM" id="CLU_485882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="561" mass="63492" checksum="38F158BE4D10067E" modified="2015-03-04" version="1">MYWRHLNSSPCEDTNSPTLLLASNISSSSYRIYITDLTTVWSESLSYLEIRKRSYEENTSIDPSSEDQFAILLDKIDQAVNGRPGTALKLRVNGKKTTLGIRDLILQLHVDMPQRLTAFEWPVQLSAGSPALLTEAMTIPLLRAYRQSLGNLDFLSQSLKLKDIIVEKLIDKLEEYGIDLGLVFPQILGKQRGKVDRECAMKKVRGLAKFDIKSLKTFHDLDNSTENIGCLIKNLFKDEKNNAISFEIKNCLDRKEHWWESMLESSIDLRTEFIATKDSLQEVEMAQTSFRHLHDGFSDSRDERTSRNQTKSDIFFRDLPSTTSTILGNNETIFFNKKCSKLEAEIEMTDSEVESDNAFSPLPGSSKKSEEFKGTKLEPEPLSLPLSYEKLSTHEVKPITSLSNSIQPIERKGKLMVLKGRKIGRMPSKDSVTEDNTALKAQDKKVLSTVPLISASSMKKNLGIIKGTKEKKGIKRLPSLDPFDSKLCCEKQQNIQKNNNGNSNNQTNSLESFSPDIKKPPENIGVKEDPLEKANRKRAELRKEIEIKMASNAPAKKTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ0</accession>
    <name>A0A0B1PCJ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000920">
        <property type="protein sequence ID" value="KHJ34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="24371" checksum="E3D04298648CA819" modified="2015-03-04" version="1">MSTMAGRMILQQRLAISPSLFEKIKPVNSGFALSPCSTEAHETILNAGNGLFLLGAKLESATNWIPMIIRTVPTSIRKVQEEIEVSSSMLIDKVERVCSIRPAHMKLAPSCGNCGSTNHTEDLCTAATKCRNCGGPHRSDSHRFLARPTRSGAPTKEQMKTFRQVGEREYQAVLRAKAAEESAAAAENTIIDLTSSQDKEIYCNFDKIQAFPIENSTSGALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD84</accession>
    <name>A0A0B1PD84_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000629">
        <property type="protein sequence ID" value="KHJ34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD84"/>
    <dbReference type="HOGENOM" id="CLU_685490_0_0_1"/>
    <dbReference type="OMA" id="GPWRILC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="402" mass="45707" checksum="26A4E5F8652F2B08" modified="2015-03-04" version="1">MINQRKHVLSNNKARTNALSANTAEKPNVIKEHKKDTMQKAMNDCPKNSFIQDEWPSILKQHLKMLESHINFLEKSMKRAKNTKPNELLQSELEDAKSWSKIYQVMDAAMESLRKSRVAAIGILPVHKPFTKKELDRKANKSLGVEALDQWDKDTASLNTQDEILEPELSKKGTSADAEDSSDSSAQLVPPHIDMKKLCLSRKSKKPKVETSHKRCTDGAQKYTQATKMNMNGFTKDSSNNSVQEANYTFSSKKKIKRVQLVEPDRRFEFNGAAGPQNDPTATVSIIEPIEKDIDFAAIQIRLQEEIAAGERAAKEARGSTSYTASPSLVNLNSRKKKRRRRSSDDLNQVRHVGKKIRSEKIERAYKDKKRKADEIEVNKEMNDSKRKKILKILKKDSLPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ1</accession>
    <name>A0A0B1PDJ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 40s ribosomal protein s11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000404">
        <property type="protein sequence ID" value="KHJ35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ1"/>
    <dbReference type="HOGENOM" id="CLU_073626_0_1_1"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="18473" checksum="88F7D2E44DB392CA" modified="2015-03-04" version="1">MATELTVQSERAFQKQPHIFLNSKVKTKSVKPGKGGRRWYKDVGLGFRTPKTAIEGTYIDKKCPFTGLISIRGRILTGTVVSTKMHRTLIVRREYLHFIPKYARYERRHKNLAAHVSPAFRVEEGDQVTVGQCRPLSKTVRFNVLRVLPRTGKAVKKFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDK6</accession>
    <name>A0A0B1PDK6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rrna-processing protein fcf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDK6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDK6"/>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="193" mass="22053" checksum="469B76C01AE8E3DB" modified="2015-03-04" version="1">MGVAKKTRKFGAVKRVIGQNDARLKKNQGKAEEIEAKKKSDIVREVPQVSSALFFQYNTALVPPYSVLVDTNFLSHTVQRKLPLLETLMDTLYAKCIPIITSCVMAELEKLGPRYRIALQIARDERWERLRCDHKGVYADDCIVDRVMKSKIYLVATNDRDLKRRIRKVPGVPIISVARGKYVIERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDS6</accession>
    <name>A0A0B1PDS6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000369">
        <property type="protein sequence ID" value="KHJ35510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDS6"/>
    <dbReference type="HOGENOM" id="CLU_2724100_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="72" mass="8292" checksum="2CF1EF720B4CC7C6" modified="2015-03-04" version="1">MLEKFMRIDGFTVKVSPEIALEDIKFEISVLQKGITWTQKSILNAEQESLIVVSFTSSEWELPSMKHNYVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDX8</accession>
    <name>A0A0B1PDX8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitotic check point protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000014">
        <property type="protein sequence ID" value="KHJ36458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDX8"/>
    <dbReference type="STRING" id="52586.A0A0B1PDX8"/>
    <dbReference type="HOGENOM" id="CLU_029367_2_0_1"/>
    <dbReference type="OMA" id="MEGVHKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="58"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="39258" checksum="A189309CBF1099B4" modified="2015-03-04" version="1">MTPTSSTSRRPTNKKPVAADSLSLDRLIRDGPPGRDISNALESMRLKILDQGIKSDADGMSASRIYIWMILINAPILETDAYLALIHRGASPAYSKIRNDTFRTLATDPLFRRRVSEASLIRLLNAVAWTLYDTREELNKKTSQESRYSDPLIESVSPRKKIRRQSLSLTTKSCEVSALEPGTYVQGMNVLAAPFLYAARSEAEAFVVFHRFITLECPGYVRGAMDGVHKGLALVDQVLAIVDPKLSHYLIGKGMNAELYAFPSVLTFCACTPPLPEVLRLWDFLFAYGAHLNILCIVAQLIIIRHSILTSPSPTKILRSIPPLQAELVKEVTLSIIRKIPEKIYADIVAHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE64</accession>
    <name>A0A0B1PE64_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE64"/>
    <dbReference type="STRING" id="52586.A0A0B1PE64"/>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OMA" id="GDHVMAW"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="32340" checksum="FC1B68F851794041" modified="2015-03-04" version="1">MAAHLPHLSDVEKLSSRVIRVLGGNPGQFTLQGSNTYIIGTGFLRILIDTGVGRRIWIENIQNVLNTENATISQVVITHWHHDHVGGLKHLLEIAPYATIYKNKPETGQFGIQDGQKFEAEGVSLKALLCPGHTNDHTAFILQEENAIFTGDSILGHGTTGFEDLLTYLSSLDKLRGLCRGRIYPGHGPVIQDGPSKILEYINHRKERENQVIGVLSSSKFSSNLSNHKKENHDWSSMEIVSTLYGDIADELRLSAQRIVQEILKKLEQEGKVVEIGRTGSWRLNFQSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PED1</accession>
    <name>A0A0B1PED1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PED1"/>
    <dbReference type="HOGENOM" id="CLU_020880_2_1_1"/>
    <dbReference type="OMA" id="YNAQALC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000147">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="540" mass="60339" checksum="9700228FF0B810BD" modified="2015-03-04" version="1">MLTQQFIPFAAIASIGNPELLPKSSLTVASTTTNVPQYFQTSPELWAGPTATGQAPFLAQTNPAPFAETFSFVPNTPLETAIPVVGGKKEQNVFQLMGHLSPYFPNPDGFGVHEYPLPSGARIAQVQVLSRHGARYPTTGDNVLKLAEKIAKHSGKFKATGDLAFLNDWKYKLGQSILVPKGRQELFNNGILHYYQYGQLYNPESKIIVRTTTQDRMLKSAENFMTGFFGLSWTQNATIEVIIEATGFNNSLAGYKNCENAINFRSSGGKNASDEWVEIYLQDATSRFQSSLEGIEWDVMDTYAAQTMCPYETVAYGYSAFCELFTYEEWEGFEYAIDLWFAGSSAFQSPTGRAVGIGYVQETVARLQNHTLDYSHSQINVTLDNNTHTFPLNQTLYFDFSHDTNIMSILTAFGFKQFNEILPTDHHPGPHNLTVSHLEPFGARLDIEVIKSPYPLTAQRKYDKSGKETTYLHFILNQRTLPLGFSFPECGSDRLDGWCELDTFLKIQENATTLANYDYACNGNYEVAPWGEITDGCPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEU4</accession>
    <name>A0A0B1PEU4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000241">
        <property type="protein sequence ID" value="KHJ35820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEU4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEU4"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="60410" checksum="0CE990A481AC9652" modified="2015-03-04" version="1">MEVEDEFPALATVARPTPPSPAAHPSPSPIPSITTPVQTTVNKDDNCSQPHRPILNPVAPSKRAAQNSTDSMTQSASNETYQIPAYLPKELRDIIQKRQEQERAWHFRLSICVSVICNIESTLENYKGDIEKREADLIRGYLQQAIARLAASNNVPKPSPIPLKTKPLRSTIHKEGQDLERKKLSSGTSKSPTSQSILKPQKVVFEDYNKSAIEKSSWVTVARNGHKKSRIIASTPSVPSAKILDIQKNMPQASNLNQSHKKKVIVPISDSRLFVRLPINHEWRTLSLSGLREVIVKRLGVSPASIGLIKPTSSRLLNTGAKIEPASNWIPLLAPTVPKYISTLEGQIEVNKEMLAYEIERVTSIRPASVRLYGSSNQPAPHRTWMAFFTKAPRSGFRVFDESGKVTFFKKQKAIDLCKRCNGHHPSRNCSRAPSCGNCGSVMHTENDCKALTKCKNCGGPYRSDSHKCLARPTRSGGPTKEQLKIFRTVGEREYQAVARAKAAEQRALASEDNILISSSQSSEYSNLTNQQSPVEFSIGEQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF81</accession>
    <name>A0A0B1PF81_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g5958</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000458">
        <property type="protein sequence ID" value="KHJ35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF81"/>
    <dbReference type="STRING" id="52586.A0A0B1PF81"/>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="OMA" id="PLKMGYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030061">
        <property type="term" value="C:mitochondrial crista"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901612">
        <property type="term" value="F:cardiolipin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140523">
        <property type="term" value="F:GTPase-dependent fusogenic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097749">
        <property type="term" value="P:membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990627">
        <property type="term" value="P:mitochondrial inner membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="239"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="806"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="929" mass="103985" checksum="547852BF09709F99" modified="2015-03-04" version="1">MIGRLSSIRALPQVSRAYSHTTRHFYHQIFASTGGLLHSQSAVRQARGRIWPAGYTTFSGAVAVRSVSYSRIIPKLLLKFSRIPALFGGATVAGLAYVQYQATLAGNYALDVLDKTKKSVVGLAGEVFDGAKDWAEFTQKRWENVKEQSELPEWMQRVLRIHEQILSGNESEGPGGEPPKMSRPGIATVVGASAINNYEQSDDETNFEERDALDDQMMVLTKRMIEIRSILQTLNKSNTLTLPSIVVIGSQSSGKSSVLEALVGHEFLPKGSNMITRRPIELTLINTPESQDEYGEFPTLGLGKIKDFSHIQRTLTELNLAVSDTQCVSDDPIQLTISSPHVPDLSLIDLPGYIQVVGQDQPIELKQKISDLCDKYIQPPNVILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVDDARRVALLNDKKYPLRLGYVGVVSKVPNQTSSLFKKDNSNIAASIARNEHVFFSSHTQNLENNPGISVGTKTLRRKLMQVLEQTMASSLQTTENSIRQELEEAIYEFKVQYNDRPLSAESYLAESLDMFKHSFKEFTQNFGRSQVRELLKEELDQKVLDLLAAKYWNKPITDLQPTLPEPDTLSDLPNADPESLYWHRKLDASTSNLTKLGIGRLATTVVANAIQSHVDRLISESTFASHPFARQTIIEAASAILNERFYSTSDQVENCIKPFKFEIEVEDNEWIRGRDNMSKVLHKELKACEDAVKVVETSVGGRRKLKDVVNFVEKARKGEAGAIGDVASGAGGFSNALLEKAKEVLFLHERASLLRMRISALRSKQCASKVSRYYCPEIFLDVVSSKLTSTAVLFLNVELLSEFYYNFPRELDIRLGRLNKDQIELFANEDPRVRGHLEVIRRKELLELVLQKIEGLRELEVEGRGKRVASSKKPERYRPNNENTMGKGWGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFA9</accession>
    <name>A0A0B1PFA9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf967 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000340">
        <property type="protein sequence ID" value="KHJ35586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFA9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFA9"/>
    <dbReference type="HOGENOM" id="CLU_1090686_0_0_1"/>
    <dbReference type="OMA" id="AWIDRKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="29095" checksum="D1332D8B1BB9860D" modified="2015-03-04" version="1">MKRCPSPPLQPLQLPPPPSQQQQQQQQHQQQQQRQQQQRQKKTDSNIQRRKKSYKPIQQLKSRTNKNNSIKEQVPILTQFIMSERRSSSVSPKPIRPPPRDLDAISRIDASLVFEHFTTTDAWDLGSTLRKRLLPIPTPVVINISLANQNQTIFHSVTHSGVMPDNESWVERKRRTVLRWGCSTWFMACKFGGDEKAFRERYALGNKAGDYAIHGGGVPIRVTGVEGVVAVVVVSGLKEDEDHAVIVEVIKELYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFD1</accession>
    <name>A0A0B1PFD1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFD1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFD1"/>
    <dbReference type="HOGENOM" id="CLU_065163_2_0_1"/>
    <dbReference type="OMA" id="KMVYDEA"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="191" mass="21894" checksum="149E53BE78120B70" modified="2015-03-04" version="1">MSLLETSKMPIEVTKPTPYTFDLGLLLANDPNSLPVSSANLEDDLTTIARDGAQVLINQLLSTCPISCTPDGVLLTLPQPETSLPREKPLPPPKQLTTWQKFALKKGIKAKTSEQRKKLVYDEKTGDWVPKWGYRGKNKEGEDDWIVEVDEEKERARKEGTERQGDGRRERKERIKRNERLKRANERRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFY9</accession>
    <name>A0A0B1PFY9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000370">
        <property type="protein sequence ID" value="KHJ35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFY9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFY9"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="510" mass="55290" checksum="D6826C6D2A384D9E" modified="2015-03-04" version="1">MTNFCILFDDVKAYMLFSLFISTLGPIQYGFHLAELNAPQDLIMCGHNSITKGNIHLKALGLSNCIQMTEAIFASLSSVFVIGGFIGAVITGQGCNIYGRLKTMRLMSLFFVVGSILETVAESVLTLIIGRFLTGLGAGTATVVTPLYISEISPPKLRSLSGTITQTMICLGILLTQTLGYVFRYASQWRFILVFGTGLGIVHAVFLFFIPESPAWLLLSKNPQLAKQVLQSIRSARYPIHKEIATWNNMNPTSAEEEPLIASPRSLVTRNELDNSINAEFTTGLPSKKGIFTVLHDPLYYPAVIAVVGVMFAQQLSGINSINLYSVSLLHGVLPISSRALAIVISTINVVATIICAPLVYYIGRKSCLLISIAGMGAMSFILALSLVLELKLLAAFAVLLFVGFFATGLGPVPIIMASELVGLEAVSATQSWCLAGNYMATFLVAQFFPLVNSWMNAQWGGTGWVFFGFAASAIMSFIFVAYCVPETKGKNNPDEIWGRTKQSSFQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG34</accession>
    <name>A0A0B1PG34_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG34"/>
    <dbReference type="STRING" id="52586.A0A0B1PG34"/>
    <dbReference type="HOGENOM" id="CLU_026584_1_0_1"/>
    <dbReference type="OMA" id="HDWIYAL"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="324" mass="36518" checksum="50F07EDD799DB4CB" modified="2015-03-04" version="1">MMSPISLASLRKRSPSQSDQSKTDEPSSKRRCLDIQSPKSISTLSECRVPIEVPHMFDDGPHRLLIRSVSLVLQHIGFTSSTPEAMESFCCAVENYALHLLSKVTASMLSSRRSLPIPNDFQYALSEFDIPLLSLEPHLHPPVPIPKLLIKLEQLPAEELYIPTSDKLLGEDLSGEAEKKNKPYIPKSFPSFPSKHTYKWTERESARDLDPRKIREEAAKVARQGEEALQRLTKVAKAAKEKAAKKTASKDPKSKERHKIWQSVMENLLSGKNSSLESSLKEKNSENMHTSMIVNAERQYFRKGVTARRNSLQSSDPFKSLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGT1</accession>
    <name>A0A0B1PGT1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000158">
        <property type="protein sequence ID" value="KHJ36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGT1"/>
    <dbReference type="STRING" id="52586.A0A0B1PGT1"/>
    <dbReference type="HOGENOM" id="CLU_052367_2_0_1"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="26953" checksum="B05C07602D2115A8" modified="2015-03-04" version="1">MTGKLDQSLDEIISTQRRSHSRGKGGRRVRHSSRAVVINPAGGIRKFPKASKGTIKNVPTGPSGGTGNGKILVTGLPKDVNEGMIKEYFMKQVGPIRRVELSYGPGGISRGVANITFVRAESAIKAVDECNNVAIDGKPIKIELILDATRVKAIPPPKGLSERVTQRPKPKSILTKVVTTSGPRGKRASRAGRSARPVKKTAEELDSEMVDYWQNGSTAVETNGGVSGAPVTNGDANMDEEILVSFPHYIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHH2</accession>
    <name>A0A0B1PHH2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-flanking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000171">
        <property type="protein sequence ID" value="KHJ35994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHH2"/>
    <dbReference type="HOGENOM" id="CLU_063290_2_2_1"/>
    <dbReference type="OMA" id="KFTQGET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="21325" checksum="31DC1BFA1C2529A0" modified="2015-03-04" version="1">MNAKGDSKNSSKSKKIISNRYIEDDYDLTSAATHATKHAGNSDEAIAFSSAVRSLGKVKQSASKDLNIDAQEAAELQRMFFPLLPSPSPPKIKATSSDMGIAAAIQALKMLTGIQSGESKNTFICLSPITPQGSSNNMNALVGIAMAEASMLFEAQNEQNNLARGAMKEKAIYEAGEKALQMYLTSNGSSSGGLIALAAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIL5</accession>
    <name>A0A0B1PIL5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd tetratricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIL5"/>
    <dbReference type="STRING" id="52586.A0A0B1PIL5"/>
    <dbReference type="HOGENOM" id="CLU_021696_0_0_1"/>
    <dbReference type="OMA" id="CERCVWE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="274"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="628" mass="70695" checksum="58A9298CB69EC9A7" modified="2015-03-04" version="1">MASGTGTAIFGLAAPFGPEAQSSLESHADVTTLLEKRQNITAKLLQSPYDLILYLERASIYVALGYPDLAVGDSYRALLLCDECTSNGGFEYQELAWSALETRCLDDNLPEILPNQVKNDQFNPEVADILYSSFESSDENLRNFEENEELENGSSIPSHRSFIVLRAAYLASLQCYRNLATGLLLCLCQKSAYEFCSRGLTLVPDDSELLLVKNYIESTARTKDANGIEKLEIKNLPDEGWARREAYPWNQYEPDRFSSSTLDFLNTKLAIIAPKCEVRITNLLSLKNSSTPVSLAGKQVKQIQSNLPSTSKQLGIFAKENILPGESILKELSYLTVNNRLKGPLCDACSAEIPSLYETESTAMSCLECDEISFCSDECKRGAELEYHPAVCGKDVETIGKDWPVKEKPFGLYFLLLCRAIAMASTQDLHPLNLPQIKYIWGGFLPTFEKATSIPSIHELHAFNFKKNYEDSSLALPFSFKFNVAEPLHVLEKMDIDIFANLENYDLWVLNTLYCKLRGTASARMNKNSGRLEAVAVHPFWCLANHDCDPNVQWEWTGGTMHLWCRETRITARHKSQHQHSGIKSGEEILNHYCDIELSVRERREWAKGSLGGWCQCTRCLLEEKDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVF7</accession>
    <name>A0A0B1NVF7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004556">
        <property type="protein sequence ID" value="KHJ30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVF7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVF7"/>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="225"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="374"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="674" mass="81169" checksum="23F57402137B563E" modified="2015-03-04" version="1">MESTRGPPRVKNKIPSAIQISAEQLLREAVDRQEPGLQVPTQRFADLEELHEFQGRKRKEFEDYVRRNRINMNNWMRYAQWELEQKEFQRARSVFERALDVDSTSITLWIRYIEAEMKTRSINHARNLLDRAVTILPRVDKLWYKYCYMEEMLGNIPGTRQVFERWMAWEPDETAWSSYIKLEKRYGEFQRAREIFQRFTLVHPEPRNWIKWAKFEEEYGTCDLVREVFGNAIEVMGEDFLDERLFIAYARYESKLKEYERARAIYKYALDRLPRSKSLALHKAYTTFEKQFGDQDGVENVVLSKRRVYYEELLKENPKNYDIWFDSARLEETAGDPDKVRDVYENAIAQVPPTLEKRHWRRYIYLWIFYAIWEELESKDIERARQIYLECLKLIPHKKFTFAKIWLLKAHFEVRQHNLSLARKTLGQAIGMCPKDKLFKGYIELELKLFEFSRCRTLYEKYIEWNNANCQAWIKFAELERGLDDLERTRAIFELAIEQPLLDMPELLWKAYIDFEEEEGEYDRARQLYERLLEKTDHVKVWISFAHFEINIPDEDYEDIDEEEAEAKVSEAAKTRARNIFQRALKNMKEKELKEERASLLNAWLSFEQTHGSEKEIEKVQKQMPRKTKRRRKIDDDSYEEYVDYVFPADDRQAEKLSNFLALAQSWKKAGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW26</accession>
    <name>A0A0B1NW26_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 40s ribosomal protein s19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004890">
        <property type="protein sequence ID" value="KHJ30173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW26"/>
    <dbReference type="STRING" id="52586.A0A0B1NW26"/>
    <dbReference type="HOGENOM" id="CLU_108559_0_0_1"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="16555" checksum="E8E59F77C1041697" modified="2015-03-04" version="1">MTGGISVRDVDAHKFINAYSAFLKRQGKLSIPGWVDTVKTGPAKELPPQSSDWFYVRAASVARHVYLRKTVGVGRLRKVHGSTRNRGSRPSHHVDASGSIDRKVMQALEKIGVLEQDEEKGGRRITQGGQRDLDRIAQTCIQEDDEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWA8</accession>
    <name>A0A0B1NWA8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative integral membrane protein duf125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004661">
        <property type="protein sequence ID" value="KHJ30248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWA8"/>
    <dbReference type="STRING" id="52586.A0A0B1NWA8"/>
    <dbReference type="HOGENOM" id="CLU_078025_0_0_1"/>
    <dbReference type="OMA" id="IRETMCV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="350" mass="40246" checksum="0DD26E00A959FF56" modified="2015-03-04" version="1">MDTKLVKAVNSQRLNLLCSHGGIELLPEICLRVTELLIDSDSKAVGRLQLASKSFFALIKFHEKSVTKTVSKNYHNFEIVNGSEKFVFSFHHGLDIEELERYTYPWVSEMKFRKTIVEFLVKHEITEMAGTIDGWPSLNVCKKELQFKLNWFKSRALFLLFRLSDSVTGLYTTDTIRDQQSKFLHSLSTKELAFIGVMVEVMGHNFFIITKRTMLKYNPAQSNSHESSRSNSVSENQAGAISDLNDNWIRETMCVFEDLVQRYGPYFAWAYLEGSRDRLSKSSQWARCKIREGIANMNAFELGYTMSYASLQSVVWRAFRQKQGCGSASTWNFAKGLVEKEMKVCPNDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX49</accession>
    <name>A0A0B1NX49_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative map kinase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003991">
        <property type="protein sequence ID" value="KHJ30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX49"/>
    <dbReference type="STRING" id="52586.A0A0B1NX49"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="KMLEHPW"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="207"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="501" mass="55361" checksum="C95A7EE620420770" modified="2015-03-04" version="1">MSSPAPLLRPPIPGSRQNGGSRTPRLGLSIPSPVGAKTMKNGPKMQGLSLQMPGQISKPTLRLGDIDKNNQASYGQQIYRNHGHSSINTSIQSSSYENESQDTRSRSDSIRMANGKAGIPDSAGSQYSALTFAQYGLRQTQESPNPPPVSVSTLYSERSDNGVRMERSDSIGRLESFGRLSLERGRTLDVEELDDEGWRIASMENRIQELSSLGEGAGGAVTKCVLKGGKTIFALKIITTNPDPDVKKQIVRELGFNKDCANEHICRYYGAFVETSTATISIAMEFCEGGSLDSIYREVKKLGGRTGEKVLGKIAEGVLNGLTYLHGKKIIHRDIKPSNILLCRDGQVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSTGVTLLEVAQHRFPFPADGTDVQPRAGLIDLLTYIVRQPVPKLKDEPEAGIKWSENFKYFIECCLEKVPSRRATPWRMLEHPWMTEMRSKRVHMAHFLATVWGWDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX90</accession>
    <name>A0A0B1NX90_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g0139</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003900">
        <property type="protein sequence ID" value="KHJ30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX90"/>
    <dbReference type="STRING" id="52586.A0A0B1NX90"/>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OMA" id="CKMKKHR"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="58870" checksum="ACA35A5450114A95" modified="2015-03-04" version="1">MSNVLIFAGSSCPALTSSICSRLSTSPAPVELSQFANGETSVKILTSIREKDVFVVQSGSSRINDSIMELLILISACKGGSANKITAVLPYFPYSRQSKKKSHRGSITARMLANLLSIAGVHHVITIDLHASQMQGFFKCPVDNLHAEPLIATWIRHNVPNWHEAVCVSKNAGGTKRVTSLADALKLNFGMITTDKKRGGTRKIPNETTTTKNDNSSMTRPKTIAKNTASGQLLNQTIDSTDSLSSQSQNSCFVNNFGFKEDTNVLSKNTRSETKTYNTSNSQLETAINKKTELLQEPSDVIPQEKRHIASPPNSLLRSMSLPAIPVPAEEELEFIDERARDIIQGRLVHGHIVPDDYPSPPSISRLTKLKSLESDSDETTQIGNFEENKQPLLKPEEVDVTSDEEEENFKSNQFERMITLVGDVRNRTVFIVDDMIDKAGSWIAAAECVVKRGGAKKVYCIATHGLFGGDSLEELQDCDCIDTIVVTNSFPISSKKVKAANKLIMLDLSHLLSEAIRRNHYGESLCPLFTHSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXL1</accession>
    <name>A0A0B1NXL1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative plasma membrane low affinity zinc ion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003724">
        <property type="protein sequence ID" value="KHJ30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXL1"/>
    <dbReference type="STRING" id="52586.A0A0B1NXL1"/>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="OMA" id="HHHGHFN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="402" mass="43763" checksum="FA2039E649CCAEEE" modified="2015-03-04" version="1">MSSLEDSSIHKIVVSVLEKLIEMDPLDTSRSVTVDCDDGNGFESSKIGLRISSIFVIWFGSTAGALIPIFLSKSKRTNVSSWIFASMKYFGSGVILATAFIHLLGPATEALSSPCLTGRITEYSWAEGIVLMSIFVMFFIELLAHQYDVFGNDFHDSEVISSSINYDSKWAERSKELPKLSDSNGAPNSNDAGSASNSLDREDLTTRNSVSNVQNGSRATVNSQNPINNDPMESRNNYFSAQLTAIFILEFGVIFHSIFIGLTLAVTGSDEFNILYTVLVFHQTFEGLGLGSRLASVTWPKGKSWLSWVFGAAYGLTTPIAIAIGIGVHESFKPGSQRATIVNGIFDSISAGILIYTGLVELMANEFIYNKEMYKASPKTIIFACLNMSFGAAVMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXQ1</accession>
    <name>A0A0B1NXQ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative negative regulation of gluconeogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003671">
        <property type="protein sequence ID" value="KHJ30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1NXQ1"/>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OMA" id="ANHETAR"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="336"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="8">
        <location>
            <begin position="336"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="46960" checksum="F1F2970CB0F70094" modified="2015-03-04" version="1">MADHIASKLNPDSHLILDQHLLRLPYELMRKNFKVAHYSIEKESTAIKSTLKDTAHASLSTGTSVDAVLKNFDTMLARIRGLKRKLTICAEEERKLQENSLIRIRHLKELYAMQSLDDVKYEAWSRTRLDRLMVDYLLRNGFQNSAVALAKEKQIESLVDVDTFVQMNKIRESLMNQSVTEALVWCHENKKELRRMESNLEFLLRLQQYIELVRTQDQSKLLESISHAKKYLHPYRASYPREVRQACGLLAFPPETRAPVYAILYSQDRWQILANLFSQTHNTLLSLPSSPLLHIALSAGLSALKTPSCHSQNKNTALAHSSCAATSSPSFTTPVCPICSTELNSLAKDVPYAHHTKSHVASDLVLLPNGNVYRKQWLREYSDKAGLPYGQYKDSNDGKIFMEGDLKKLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXU2</accession>
    <name>A0A0B1NXU2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cap binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003123">
        <property type="protein sequence ID" value="KHJ31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXU2"/>
    <dbReference type="STRING" id="52586.A0A0B1NXU2"/>
    <dbReference type="HOGENOM" id="CLU_013816_0_0_1"/>
    <dbReference type="OMA" id="CAAEGLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000045">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="328"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="535"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="788" mass="89484" checksum="EA7596028CD6F9A4" modified="2015-03-04" version="1">MMTDQDQRHRGGRSNFNSSRKRRYRDEEDYDRRPQRRRQEEPLFARIRRQLLSVAESPVKRVEDEIISIAKTICDNVEDGELKAGFIELVIQLVIEQPFKIPFIAAVIMYADTIQRELVTEVLDKSVTKLNDSIQKGDWREVKLLMKFLGSLQGVLEGEGIWIVLQDLLTKAVDLQTENNEETIGPEIVKIILFTIPYVMSSSATGNQQRAASMIENADIIASEPHVLQTLVDQYPGDGELEMASSASVLSLLQKQLQNEAAGGWVLACLPRPWKKLLESETSTESKPLEKHPLPPINIPESVTVGPRPLFPELYFSVYANQDVETVPPTTDIASCLLRDAIVDTINILDYNRNATAQFLIGIDCYFSPSTFVKRATPFDRLRDIEGGKLTWKPEDVVVDAVFSQLFQLPFPEHKLVYYHSVLTEACKIAPAAIAPSLGRAIRFLYRSVDCIDLELSYRFMDWFAHHLSNFGFTWKWTEWIDDVELSGLDPKKAFIEGTLDKEIRLSFAQRIKGTLPMPYQLLISEEKEKDTPEFKYSQEDTPFAAEGREILSLLRKKSTEDAIQPVIDRIHARAIEMNIPDPLVVSTDAYMTAICYIGSKSLSHVLSCIERCKGRLMALGPVSPAARKQIIESVMEYWKDQPGIGVNLVDKLLNYTILSPESVVEWALARDGTRLAKAYIFEMVSSTISKVTGRVRQVYRAKSVSGLSPEQTKILINTVESERASMKNLFQLLEKYLLGWINLYNGAQNGTKNVEDVLTNEWANRWLRVFKRKLAVEDAWCAEFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY52</accession>
    <name>A0A0B1NY52_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna recognition motif containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003488">
        <property type="protein sequence ID" value="KHJ30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY52"/>
    <dbReference type="STRING" id="52586.A0A0B1NY52"/>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="OMA" id="CEPEDAP"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="335" mass="36025" checksum="92EBA8E57CEBE17D" modified="2015-03-04" version="1">MSSKQPSKSVFVGNIPYGLTEEQIIRIFSSAGKVLNFRLVYDRETGRPKGFGFVEFPDSDSASSAVRNLNDYEIMNRKLRVDFSNDGNDEDNSNNNTTSTTTQLALPYQSFPPSNGLPQPPNSSHIMVPQTNPTNNSSAIPPLPLGVEVPPGLSCPDAISRTLNTLPPQQLLDVLSQMKTLATTDAAKATELLHQAPQLSYAIFQALLLMNLISTEALGSVVEQATTAAAAPINHQVAPQVAPQVVPPQQPIPPVYGALPPNAYPQTYTAPQPSYGVPPSRNQPVIAQATPQPVAGGLDTEQLMQQVLAMPQELIDTLPVAERNQLLALRASYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYD4</accession>
    <name>A0A0B1NYD4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative slx8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002949">
        <property type="protein sequence ID" value="KHJ31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYD4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYD4"/>
    <dbReference type="HOGENOM" id="CLU_980694_0_0_1"/>
    <dbReference type="OMA" id="NLMEANK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="284" mass="31766" checksum="DC1D7F193D8390C4" modified="2015-03-04" version="1">MNSSADNNVEDLSRSKIQDSLPRSQPITSNNEKNFNSSLLPSSTNENLRTHRNTASISTSVNLEDPSFTLDSDDYLFVTPPPFNQESITPQTPPHPSSDYGDLIEYDELVFDLTDSPPVTVSEETGKRLATSTTDERPTKNARVNSSGDASKTRIKMSEEIDMVDLRDVDTMAQWEEKKAKEAAEALKERNLMEANKPFKLSDFQCIICMDSPTDLTITHCGHLFCSECLHQALHMGDKKCCPVCRSAVYLPRPGSRQTKNGIFALEIKLMTKTKKDKRIKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYZ0</accession>
    <name>A0A0B1NYZ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002729">
        <property type="protein sequence ID" value="KHJ31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYZ0"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="183" mass="20201" checksum="43B2A7DCE5ECF3B5" modified="2015-03-04" version="1">MKNNTANQTASSGPDERLFLRFDKNHEWRLLASSGVRELLCEHLNCIPSDITHTTRTPIGFALTVKEKKTSQKLLNDSDAISTQGAKLEPASDIITYRIATVPVALRTSIGSVTGDDTNLASDIVRVTNVAPKMVRVHGKTRAGAPHRSWLAHYPREQAPQPGFRLFDESGVAVLYKPRKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ46</accession>
    <name>A0A0B1NZ46_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003065">
        <property type="protein sequence ID" value="KHJ31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ46"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ46"/>
    <dbReference type="HOGENOM" id="CLU_002055_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="69036" checksum="4247A49EB8A78A8D" modified="2015-03-04" version="1">MIDTGVAATPTAGYNQYLAYNKLSNVNHDISIAGQASIRFGVGSAVSIGSVMVHMPLGFVEFHVIKVDALFLMIIADLGRLGAYYNNVNDILVTKTLENLPVIRRFGHPFLLRKISPESLIQEHLATNTAFLTEIELRRLRKRFGHPSINRLRHILERSGHTDFDKNTIEKIRKFCHHCQLHSKSLSRFHFNLRDDISFNYTIIIDIMYIDGKEILHVIDEATCFQAAKWPNNVTAKHVWDTLKYCWIELYVGPPGFISHDAGLSFVSREFNQKASFMAITAISVPIEAHWPVRLVERCHHTLRRCYEIITEELNDSVTSKDMRLRMAVKLVNDSTGPNGLIPTLLVFGTFPRMCNLDPPSSDITKRASAIKSAMDEVISLRTKRKVAEAIGQRNSPSTTLVHNLTLGSKVLIFREGIAGRSGKWTSPFELLSIERETCIVKLPNGSTNFRSTVVKPYYSDNSNTVESIETTENKSLSTFNLDYSPPNIQNNIPTQRLRSPYNFRSKPLPNTFMISKILENRSSKFPNSVSQFKDARQKELNGLLEKGVFEMVSIDKVPIGIRIFNSRFVGQIKNAGTSKAFEKSRLVVQVYNDTDKKQYPYSGSDNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ73</accession>
    <name>A0A0B1NZ73_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004545">
        <property type="protein sequence ID" value="KHJ30300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ73"/>
    <dbReference type="HOGENOM" id="CLU_2005593_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="13403" checksum="BA25BD2B49EEA612" modified="2015-03-04" version="1">MLISDNDFEPICLQGKMIIDSNDDSGEKKESENTSEDSASEFKTSFAGDGVIITSDRNGRIIAKVEDEESVLLDSHFKPLMARARVGSVQAGVNINNAVSTGRLRGPRFSIAGTLIALIIYVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH2</accession>
    <name>A0A0B1NZH2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZH2"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_2_1"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="348"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="764" mass="87830" checksum="D68CC497FC1795E2" modified="2015-03-04" version="1">MESLKSSSNTSAEVDTKLVSLAKRHKVKKAKEQKPANCKADGQIELSTLPAFLNERLELYQKLKTKFDEEIAAKTREPITIILPDGSEKQGLSWKTTPADIAKGISNSLFKRTVVARLNCDDNQLWDLDRPLETSCKLDFLSFEDDLGKKVFWHSSAHILGEASERIFGCSLCIGPPIENGFYYEMSLPNGAPVQQTDWKPLETLVSQIVKEKQPFERLVLSKENLLKMFSYNKYKQHIIKDKIKDGELTTVYRNGPLIDLCRGPHVPHTGRIETFAIMKNSASYFLGDKNNDSLQRIYGVSFPDKKQMAEHKKFIEEAAKRDHRKIGRDQELFFFHELSPGSAMWLPHGTRIYNTITSFLKEQYWKRGYHEVISPNIYNSELWKTSGHWNYYKDDMFTFGDEKETLALKPMNCPGHCLMFAHRERSYRELPWRVADFGVLHRNEASGALSGLTRVRRFQQDDAHIFCREDQIKDEITDLFDFLNAVYGLLGFTFKMKLSTRPEKYMGKLEIWNLAEAKLCSALDEFAPGAWELNEGDGAFYGPKIDITISDCLRRQWQCATIQLDFQLPQNFGLEYMSTEVIKKSEDAISSINKEEDSSKNIDLTDPKIKKERSIKPVTPGCARPVIIHRAIAGSIERFTGILTEHFGGKWPFWLSPRQILVIPVGVGFYDYAREVQAIFRDQQMFVDVDLSGNTLQKKIRTGQLAQYNFIFVVGDQEMKGREVNVRNRDDTSSQDRGKPVPLQEIMSRLLVLRNERRQSNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM4</accession>
    <name>A0A0B1NZM4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative leucine rich repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002897">
        <property type="protein sequence ID" value="KHJ31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZM4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZM4"/>
    <dbReference type="HOGENOM" id="CLU_016204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="686" mass="78541" checksum="85AD64CCA43FEC2F" modified="2015-03-04" version="1">MISIPPSYQEATSKKLWPEVARFVERKDLLSACLVCRKWHQIFSIRLWGNLGIHFDTDDHFTPSNIITISFKLPLAVLESSLCTHSFLASLAHLGRILPSVRIEVRGLVHTLCMPSIQVSLFDAFPRGWLSYFLEYLPNLQSLIVSNLSFFDHQSLIALGQKTSLTNYPLKLLIASNCVNTTARCLSNALRYFKSLIYLDLSATQGARDSSVLSQISSLLSLCVLKMRRCGLRDNDLNSLSFPPQLRSLDISENFFTEMGVAILIDKLPKGPPAYKNEYFSNYKRINYRYADLPLSLRVSHEGIETYVLRRLTSEIDGYLQLEEGLPLTLNHLHLASNRLTINSFCRIFGHNQYLQNLDIGNLQLNRLSFYKSQIPRYHKQSTIQLLDSEIFSAIFKRLKSLRVHHSIMTSNPFAQKLKSDYDNKEGLICFKSDRSAEFDNTCNLQDQFQSSNSSNNEQSYKKKPPEMFQLLNKPIYQYYSIEADRIESRHPGRFRPQFLPNIRLLTLTGIPSHVSDFHIPNAINLFILECGEDANKFSSSSLYSDLLAKTPTPSVSRLKELKTLTLEITKEEQFTLAERNPSPVKMDKDASYEQTRFSFFQGFCNDEENDFSLGSTLEEASSIDVISIIKEKCKKLLDLHHELNNIIEFKSDLQYFSNFSSSKGGKTRYWKGGIRVNISMKDFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P015</accession>
    <name>A0A0B1P015_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EV44_g6414</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01003852">
        <property type="protein sequence ID" value="KHJ30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P015"/>
    <dbReference type="STRING" id="52586.A0A0B1P015"/>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="394"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="617"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KHJ30630.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="771" mass="87054" checksum="E69FEEDDA0307969" modified="2015-03-04" version="1">MADGYRYSQQTAGGYYFPHNSQSHLSKHQQIIRKNTPPNNIGVSFNAKTPSPTKSPELLSSAPGLYSMYNQSHQQQQHGRVNGGGRGMPILYNFQHQNSHQQHTQHHSTIQQDHTSHTVNGSVLNRHTSHSSSVLTNSTPTFAPSGLHSGQSTSTRSEQTSQISEHWSEQLLLHKESERLHYDAKDRGVTNYFARNKAQDNKGLVPTLPQTEPETSDGISNELGRMSNQSNTTRRQDWHNMDLSGQGLRALTSPLFNYVFLRELYLASNSLTLLPPSIGKLRHLTHLDASNNQLSSLPRELGMCVYLKKLLVFDNQIMKLPHELGSLFQLEMLGIEGNPLDTVQKSVIMESGTKALIRNLREHAPKPNDPIPRKMISLLDESATPPEETIKVFSFNILSNQACTQRLYGYTPQAALSWEHRREAVLNEITATNADFVCLQEVDTDTFREYFSMKLAYADYKGVFWPRSRAKTMSEKDAKNVDGCATFYKHQNYLLLDKQLVDFANVAINRPDMKNQHDIFNRVMPRDHIGVVCFFENRLTGSRLILVNTHIFWDPIYADVKLIQTAILLGEVNRLAEKYVKWGPRKENKLLNQTDENSVSDVREQTPQPSKEYASKTQIPLIICSDLNSTAESGVFELLARGTVKPNHPELGGRSYGNFTKDGIDHPFSLKSAYTNLDKSQDSVPFTNYTPGFRGVIDHIWYSTNALENISLLGQVDPEYMKTVPGFPNHHYPSDHLSLLAEFAVKGSKLKINISEQDTVSSNQHSGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C4</accession>
    <name>A0A0B1P0C4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004592">
        <property type="protein sequence ID" value="KHJ30274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P0C4"/>
    <dbReference type="HOGENOM" id="CLU_000961_3_0_1"/>
    <dbReference type="OMA" id="MQISPKP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1350"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="715"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="817"/>
            <end position="909"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="949"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1015"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1210"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="8"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="29"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="715"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="817"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="845"/>
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            <begin position="877"/>
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            <begin position="1027"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="1055"/>
            <end position="1067"/>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="1250"/>
            <end position="1259"/>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1641" mass="181546" checksum="47C54EC1D5E40D37" modified="2015-03-04" version="1">MEDNRPYLIPPPPPPPILLQNQQPSVINIPPPPPPPRAPMQQNQALGGVLPPPPGPAPINSNRRQGSLGRPFDPRDNYLPPQNLSKNYKPPVYNMGPNYPTPLTIPPPPINEQMSATYIPGGDSFGPGVGIPAFMSADNSQASNSTSRNLYKTSSFSSRDDNGNYYQNRDPLYQIATRYSNSQPPPDYRTATSQINNQLLNKGQHTPISPIDAGSQWPMERVLSWLASNQFSQDWQETFKTLKICGSVFLELGTGQGGRGNFGMMHQKVYPRLAKECTNSGTGWDQAREREEGRRMRHLIKNIVTGKPQRLSKSSNLRGEVVSGLHQSVSTDGIQESSPSLSRKLQNSTPITANTEDESPMLGRSGNSNSERGFTTKTKNRTSIKNSTNLDSESTNSAQTRNNFRNALKSTDDNSRLQSPNSSETGDGTLRGPTLRIDSSPKSSSPGGQSFSQANANLNVSPYNGRYGNRGSISNLSVSSSTAIYGSGVPPGAAQMLLNISGNTGDSSETRNQESPLQQTDGARLSPLDSGERSAGSEQLNYTRESKRFLNHFRKRRKDDGSAQYSEYLNLESSTSPHPNTKPGYLFSNGQNSNASESSLDRLSPTLSATETDQIKQIIGKRGRKINTDKNFILVTLDGWNYRMCDITNVKSAQDFQEILKDNLKIHRNAYLRIFLTELGLLVHEKELDYQKIFQYKKQRKLEGLKFFLSVDNTKSANDPSSSNNVDEDSYSLLSGARRRSSSSPPIAGPNSQNLDQQALGKKTWEISSEKIRDRLGIFRSPQDENGVSLLPEANRQFVPDLATSDYRIESERRQKEFMARKKDQKQNKVPVTNDGTLGIVGRNVDFDQPRTSPFEDKKQDNLLPHRKPPPPPAESATLTKANSMSSSSGKQRPISTRSHQSRGSDDLYVSGEETNYLSQETSQGNIKRNLRNLRKIETGKTAISYIDFTTSGSGKSSPRSASGTPGSTTWGKGDTSFIVPDYKDDANSDNDISLPLQMNVDITTLDYEQASLAGDLSPSSAYPDSPPDRSIDRKSYGPDFEFTETNIDFKESTQEFDQDDSDEDSNDGLFAVPISSKQNSRKSSIRKMNSIRSNKDIGGVGGTENKPQLTIETRSKKGLSVTFKSPQNTNSAGLNADLSQNRDIENQSRSQNVKATESQEEIDAKLQRRKSFAREDVWANRPPAESLIDHLDAFFPNLDLDQPVVEESTGISDSDFLIPESEVNERSDVSQDSDETSRKFSQSIGSDEQTLKALERPESIHSVAQRNIRRSGGLGRMKSIREVARGAHEASKRFTAFTQTGEEPSKILRRKSTKMFGANIVQIKPERGSMMLPKIPQDLIPKRQATFRWFKGQLIGKGTYGRVYLGMNATTGEFLAVKQVEVSAKAAGYDKDKMREMVAALDQEIDTMQHLDHANIVQYLGCERKETSISIFLEYISGGSVGSCLRKHGKFEEMVVSSLTRQTLSGLAYLHREGILHRDLKADNILLDLDGTCKISDFGISKKTDNIYGNDASNSMQGSVFWMAPEVVRSRGQGYSAKVDIWSLGCVVLEMFAGRRPWSKEEIVGAIYKLGSLNEAPPIPDDVANAISPIAVAFMADCFTIDPSERPIADTLLSQHPFCKVDLNYNFLDTDLYAKIRGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J6</accession>
    <name>A0A0B1P0J6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002259">
        <property type="protein sequence ID" value="KHJ32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0J6"/>
    <dbReference type="HOGENOM" id="CLU_003878_0_0_1"/>
    <dbReference type="OMA" id="AHPHQWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="854" mass="95358" checksum="98E2CB214A85CA02" modified="2015-03-04" version="1">MHSQCDPVPNRQSRSNRSPLLERSDSEINSNFRPAIRLVPKTPPKLLGSDTEDDTYYYSRTPLPTHPSHFLVPRKAAARVFASHQQNFEFHNPSKNSIKSSSLRGLTAEPTPIKSAQSIIKSQPRSRAVLISTGSPSPKPSVKKRQLRIHEDNKTFSLCTPGNDEGSETKTRASRRENVMSTNPISTRSSSSLSRQASPPGLGNEKRHPEQGPLTHLIIKPSSKQPMRNTNDSDTSPVSDKSKRKTLSDSINSSPYNYEFIGGLRKVAETPDDKRQKITSSEYHPSIVHLSDEVSSPTVSHDLLSKPSFSSTNSISSETTNYKIYGEASVAGSNSSAITFSPLPASSENTILDSDRASPSEEKQKKSHEVLGGSSHSNLLSDHQNYHPLSLTYSSIQKKAKKVNSDYYREFPKSKESRNLEFSSLSLTPRESYRGLFSSKSLIKFPFHAFNLNQSQIFSSSWAETLSLYPPRSHMNEYPHQWSSQLSTVLSVSEASDQDARSWSEDSRDSIDSRGRMMSTGSVGTSQDLISPISRNMSWNDSIIDRPPSAFKKPRRNSTSPIRTVVDQDEHGDGITDMHNMRVRPLRRRTSGYLSSASSDNGRTNTMRSSVSTHSINLTLALLPAWAKLYYGGGERRLLHSSRSSMGGIDSRTNSFRRVSSSPDLSTTGFPTSRKRPKDKIRHRESSIEVDTNIMNLRSGMGRQLNSTMPLATWNVANLWSPHLRPDKRSKRSCMWGPPTVDQGAEAGLFGRRNIQVVMFILGFIFPFSWMIASVLPLPKLPVVEMRDDDRLSPNLDTFKNERDINAIDEARYESAAWWRKLNRWMSILGVLIIAAVVVLVIIGLEQGWGMDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P4</accession>
    <name>A0A0B1P0P4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative short-chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004126">
        <property type="protein sequence ID" value="KHJ30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0P4"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_7_1"/>
    <dbReference type="OMA" id="NQKGGWY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="24203" checksum="FDA55FBDA4A377B7" modified="2015-03-04" version="1">MKNSHLFREVGLSIYADESTISRAAEEAKSMFQSPTANPLHLAFCMPGILHPEKSPSQMNHTDLIETFAINSIGPMLVFKHFSPFLPGKKNTPFQSQTDSSLLPTQAIWLNMSARVGSISDNNLGGWYSYRASKAAVNSFTKSFDLYLQTRTGGNAMAISYHPGTVKTDLSKEYWAGVPKEKLFSPEFAVAKMWEVIKGLDLSSRGKCFDWKADVILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0U2</accession>
    <name>A0A0B1P0U2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002548">
        <property type="protein sequence ID" value="KHJ31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0U2"/>
    <dbReference type="HOGENOM" id="CLU_151460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="105" mass="11772" checksum="F6CF3AACBE02C06A" modified="2015-03-04" version="1">MYHPAKSKSSPSRGAGVNAQYALYVWDSQEDSHNPSLQDSHSSPRVSIVFVSTSLSPQQLLSRSPHDWPREYRVKGSILSQRTPDESKLLVQMVGCWLDFLEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P138</accession>
    <name>A0A0B1P138_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative u1 snrnp-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002175">
        <property type="protein sequence ID" value="KHJ32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P138"/>
    <dbReference type="STRING" id="52586.A0A0B1P138"/>
    <dbReference type="HOGENOM" id="CLU_009938_0_0_1"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="635"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="728" mass="81457" checksum="661215D650EFFF6E" modified="2015-03-04" version="1">MSAPGTAPPLGMRQASIAQANRPSGLPASFQGPPNMPNINFSAPIIRLGTGPSKPNVPNSGMGGQTQDYRIGAGRGGIGLDRGVESQRQVLLSLIPPTKEEIIRTIFIAGITEGVGNDGIERILSSVGRFRRWDRAIDAEGKQCSFGFAQYEDVESLSIAVRTLKDIEIPLKKQKVGEKSVNKEEDTASIEKGKLLVFVDDNTMKYLADWDSHRGDENSAIQARLDAAKQALQSVVHELFHPPAFVKVETGREDIIMQDIDHTDSVEVVNIPLAVDDELADIPAEMREIVAKEIAAFRDRSNRRDLERLKREEDMEAMERQRNGATRPSRLASPGLRAPSGPAAGTNNIPLGPRGAPKAPSGPKGGSQIPRDYQKGVSFVNGIGTNGAGIGNLWIDRDDDIDSASDEELERRRKSKRDAELEKQYLDQERRWLNRERSRTAAVQREKEREEEDAAKEKSEREKLAQRLKEWNDDVEATRKVEEYYLDRSMWIRNRTAFRAREAAADERDRIAEQRELEQESANQEQARGMADSFLDRTSDELGSRPESGRTQQPFKLSFGAAAQKALKEKAVAPRRTVAEVEGLLEDEEDIDKASKRTLIPIKFDPAATSTVGMTDEERDQAVRQLAARIPTEKEGLWAWDVKWDMMDETVIVEKLRPFVEKKIMEYLGVQEQLLVEVVEAHIRAKGKPQDLVEQLEGALDEEAEVLVKKLWRMVAFYSESEYKGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1A5</accession>
    <name>A0A0B1P1A5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative atp-dependent rna helicase dob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002108">
        <property type="protein sequence ID" value="KHJ32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1A5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1A5"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="165"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="432"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123075" checksum="8D5364E28F40938C" modified="2015-03-04" version="1">MDDDELFGVFQDDGDLESTIKRPKKNRPEKKKDRAKKRAANRELKDGSNNIDEDKPMPDLEAETLAEDRGSSPIPENKLIKKRRVDEVAEPIVTDTFQTESSRKVAVSAGLTDKDDDTLVIQHNIQHQVSLPPGYEYEPISQHKSPENPALTWPFELDPFQKVSIASIERGESVLVSAHTSAGKTVVAEYAIAQSLKNNQRVIYTSPIKALSNQKYREFASQFSDVGLMTGDVTINPTATCLVMTTEILRSMLYRGSEIMREVQWVIFDEIHYMRDKIRGVVWEETIILLPDKVRYVFLSATIPNAMQFAEWITKTHNQPCHIVYTDFRPTPLQHYFFPAGADGIHLIVDEKGNFREDNFQKAMSSLQDNKGADPADINAKRKGQGNNKKINKGTARDDNNDIYKIVRMIMMKHYNPVIVFSFSKRECEAYALKMSTMAFNEESEKAMVTKVFNNAINSLSDEDKQLPQIQHILPLLRRGIGVHHSGLLPLLKETIEILFQENLIKVLFATETFSIGLNMPAKTVVFTSVQKFDGTKNRDLTPSEFVQMSGRAGRRGLDDRGIVIMMISNNMEPEACKEIVRGTQDNLNSAFYLGYNMILNLMRVEGISPEFMLEHCFYQFQNTSGVSGLEKELEELREKRNVIQIPDEMTVKEYVELRQQLDDYGKDMRNIINHPNYCLQFMQPGRMVRVKKDNQDFGWGAVLNFKQRKSKGENVKFSPQESFILDVLVSVSQDSPNSQNLGKNQKQTIRPAQGGKGRMEVIPVFLSCIESIGQIRIFLPSDLTSARDRENVGKSLEEVGRRFPDGIAILDPIEDMDITDESFKKLLRKIEILESRLLTNPLHNSPRLEALYNQYLGKQQLSQKIKEKKKSLASALSIIQLDELKSRKRVLRRLGFINDQEVVELKGRVACEISSTGDGHELLLSELLFNRFFNEMTPEICAATLSCFIFEEKSQLAEPLKDVLKEHYSAIQAQARIIAKVSIESKLALNEKEYIDSFKWELMDVVMAWAQGRSFAEICKMTDVYEGSLIRLFRRLEELLRQMAEAGKVMGSEELSKLFEESLTKIRRDIVAAQSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P9</accession>
    <name>A0A0B1P1P9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003625">
        <property type="protein sequence ID" value="KHJ30786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P9"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="151" mass="16877" checksum="8D73A0B2C2555AFE" modified="2015-03-04" version="1">MRPAHLKLYGRNKAEAPHRTWMAFFSKAPSSSFKVFDESGVARKFKKQQPLDFCKRCNGHHPTRNCSRAPSCGNCGSTNHPEEICMAVTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQLKTYRQAGERELQALLRAKATEESAATAENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W7</accession>
    <name>A0A0B1P1W7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lea domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001915">
        <property type="protein sequence ID" value="KHJ32652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1W7"/>
    <dbReference type="HOGENOM" id="CLU_128874_0_0_1"/>
    <dbReference type="OMA" id="FGTSNKC"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="106" mass="11507" checksum="61DB4CA967CF5F5F" modified="2015-03-04" version="1">MLLLSRKLTTQLLKIGKILPRASASFSTSCPRGKTVIESVKKQVKETDQAIADKIVDGINASQSIAGKAKEITGLSGKEAKGKVEEKAEDLKDEAKNKKEEIKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P257</accession>
    <name>A0A0B1P257_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003336">
        <property type="protein sequence ID" value="KHJ31021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P257"/>
    <dbReference type="STRING" id="52586.A0A0B1P257"/>
    <dbReference type="HOGENOM" id="CLU_003430_0_1_1"/>
    <dbReference type="OMA" id="QLHTGFW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1062" mass="123642" checksum="B4DE0295A49DC529" modified="2015-03-04" version="1">MLDKTTTSLESGAARHIWPACKKQLQSYSGLQPRSQEVIHSECSWLTQEILKCNRVPAMVFFDFLYPIGFSSFIRQSASLEFFKPDVLFPRHGLGIKSCRYYNSSRKLQTLWSLSPGLKDIGSQSEIDIANLLEKLGLSRDTSTIRIWQAFKNASKNIQRNFRKILLKYLHHLTKDYNAEIIIELFRELDFHEKDADICEYVINAFLRKQNLLEAVKVHNFAVARLKASAGLYQILRYTVKNEIWEEAYKLWKTEKSIYLDFNFYRFVDESAPEVSTALSLSEWVNNMRKFPRKLPFADLIKFSITIIEKALQEAKYSNKNDYFALLKSISDWKPLTREIYTNVITSLIKSKNEDLVLQSYRALRRNKNFQISQAALTHVLRLSCNRHDVLYMKCVLDDYFLLYSKPSRAAYRICLREFSRQGDAKTVHALFNQYVTRYKSNTTKTLARARHQVSLRSKLDKSGKSYLFEEIDEAAPLTANDFAPLLHVHARRGEVEDLEKLFNQIKSSYGIEPDILCWNIRLSAYMKIRDLDRVYECFEQILENQNLRPDHYTLGTMMALCTYRADLARARDIFRMAKEMDIPLSFAMVNCLVICLVRNNLHSEADIVCRKSTTMALIGSKTQIWNSLLIGYVLKRDLPNVNRILKFMTENNIEYDQDTYSAFMQALAITRQPYLAARVLFEVMPKSGTKPTLFNCAVLLGGYLAIKDWDNFNRLHEYILKYYKRINASTKLLLLKATASEDGIVFEGETDSQKLLRSLSVFTETMASIDPQEISETARKGYDQLPLDIMYPAVFYSFMAYILSENNEHNLASKLLTEYKSWIPRNRQKAGEVMKIITASMSAMHGTNDMDGVSDCWERAVSLAKEESSSLAPLPQTEHRKDTSEQETRYFHQLILNKPFTIFMKSMVAQKKTKELNEAVQSLISYGFDLDNYNWNTYVKYLSRLSSYTRLAFQVCEIKLMPGWQGWRIQRRKFKGRRSNVPLEIRRKKADPRSLRPYFDTLLWMGRRMINIRAKAAESPQMKKLLDLLRNEYPNTYMALNGIPRSDDETILRSKDSQFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V6</accession>
    <name>A0A0B1P2V6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003090">
        <property type="protein sequence ID" value="KHJ31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2V6"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="355" mass="38505" checksum="DC17A6A92759FFF2" modified="2015-03-04" version="1">MSVFAGSSDYGNHQMVVRNFASDTNGNKALTSLNGFASKGTLAQAIPRTTGLQAPVIQLSGHTGEVFCGKFDPNGANIASGSMDRTIMLWRTFGDCENYGTLTGHKGAILDLQWSRDARVLFSASADMHLASWDLSTGIRIRRYIGHDEIVNSMDISKRGEELLVSSSDDGYIGIWDSRTKTAVSFIETEFPVTAVALAEAGNEIYSGGIDNDIRVWDMRKQEVIYSMLGHTDTVSSLRISPDSQFLLSNSMDSTVRTWDIRPFAPTERLLRVFDGVPLGIENNLIRASWSSDGKRVAAGAGDGTTVIWNSETGKLQYKLPGHKGCVNFAELTPSSDPIIVSGSSDCSLILGELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P300</accession>
    <name>A0A0B1P300_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003304">
        <property type="protein sequence ID" value="KHJ31054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P300"/>
    <dbReference type="STRING" id="52586.A0A0B1P300"/>
    <dbReference type="HOGENOM" id="CLU_111220_0_0_1"/>
    <dbReference type="OMA" id="QFIYCLI"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="152" mass="17018" checksum="815A6F8732EE78C3" modified="2015-03-04" version="1">MAPRKSNREHTVISTAASKSYSSKASSSKVSPKASPVSDQHLTLQQIVLGVWDNYQEVTPQRIRLVDVFLTFLVIVGVLQFIYCLIAGNYPFNAFLSGFSATVGQFVLTTILRIQTNDKNNTEFKNISPERAFADYVFGSLILHFFCVNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P301</accession>
    <name>A0A0B1P301_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001905">
        <property type="protein sequence ID" value="KHJ32658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P301"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="10469" checksum="B6588A94ED6904EF" modified="2015-03-04" version="1">MKLSGNCGGPHRSDSRRCLARPTRSGAPTKEQLKTYRQAGEREYQAIIRAKAAEELAASAKINNIEITSSQDSEVDNNIDNIPASPADISTGDAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3E8</accession>
    <name>A0A0B1P3E8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3E8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3E8"/>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="281" mass="31035" checksum="2E6957AF6D13B922" modified="2015-03-04" version="1">MSRPEDSLPPDLYYNDSEARKYTTSSRIQSIQVSMTHRALELLNLDKPSLILDIGCGSGLSGEILSSNPEPHMWIGMDISPSMLDIALQRDVEGDLMLMDFGQGVPFRAGSFDAAISISAIQWLCNAESSEVSSIGRLSRFFNGLYASLRRGGKAVCQFYPKNDEQRNMISSAAIKAGFGAGILEDDPETKNKKLYLVLTVGGGSVKEGSNDITNVVRGMEDVNVVDMRKGRNGTNSNFMNNSVKKGSKAWIMKKKERMERKGKIVKNSSKYTGRKRRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I8</accession>
    <name>A0A0B1P3I8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dbl homology (Dh-domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3I8"/>
    <dbReference type="HOGENOM" id="CLU_010210_0_0_1"/>
    <dbReference type="OMA" id="WTHIQDD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="243"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="953" mass="106809" checksum="D516F2AA2AC41FD1" modified="2015-03-04" version="1">MVKIDALKIDSHSTPNCSRQNSVHISRRTSWGTPIPPPSENETGILNHEEDAFDDVDLHKDSLESIYSQETNSCNTLENISALGLSFEGDNAEFRCTKTFETFSLDDTGDFNSQSSDLKKPFNKWTKNLERRANRRRKTVGYDTNKLTKNIDLFDSPGTQRRSAHKKSSSGSSFGFVTAVKSASISLASLSVATKPKRTALSSRRQRTDQNSKASNLLRASEDSSYIASNPFLDQAVTKRSFQRRRILEEIISTEESYVADVKFLMNVYVTLLASMPCISSNLRASITRNLNEILELHEEILGDLHQVIPFSEYTESNCVKLPSRKLGGHQRWRSLDAVPENSTGVSWLQEIPGMTIEPRVAAKVANVFGKKINRLFIYEEYGAKYEMMIKDIGTTHRTIPQWKTFQKGLEALASSLASISCQQDNTKKAMTIGDLLVKPIQRICKYQLLISELLKQTPVCDCPDSHLSIETVMMRLREATSAINQAADDPQMKSVMEKSWLLQDRISFPDMLNARSKILVRNLGHIHLCGVLHVSWQTQNSVDGKYLICLLYRDYLLLASSPRFDQVYMVQACIGLFGIGIEEVDNGRGLQCHTVKFSWKLIFECDHQLFELTMSACSSSEEQEWRSRLTKYSCRESLFTEEQSIFSSIYLPVKPLGSIFGKPGTVARRMSVHRATTVGPMSGLCQVIIKNTNAFKETTSSIAINRSQSLLTTNRTPVLAPSRAERCRLEALLSDVWSRQSLPYPGMTSRARNEHMVRKSASSMMRKLSVASIASNFTKQSGSAIFTHKELNNSNSPATHNDGIVNNNKSSLESSSRQQSFQIPDEKENVSHRNSLESLAVMAFGLGNSSTGSTRIETLKSKNSYASNSLRATPPLIRSASNNSNNNLHKLLSLPISVPLSFTVAKDIVEKDLENSITRSKPPQFSWKNRRSEKVNRKGGSVVVEGIRNFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L1</accession>
    <name>A0A0B1P3L1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001538">
        <property type="protein sequence ID" value="KHJ33262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L1"/>
    <dbReference type="HOGENOM" id="CLU_142952_0_0_1"/>
    <dbReference type="OMA" id="AKVIAMP"/>
    <dbReference type="OrthoDB" id="3564679at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="16409" checksum="E29B359078F55D24" modified="2015-03-04" version="1">MAARGTRTAKMLEYERQAEERMREMEIMNEERNRMVEELIKIQQEQDRIAQEEYEIAQYYEAEALKHAEEVRIHREEVRRHQERIREHEARLRDHEATAEAFAKIIATPSQQTRDRQVSFQASLGGRLAGMKAQQGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Q7</accession>
    <name>A0A0B1P3Q7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002754">
        <property type="protein sequence ID" value="KHJ31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Q7"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="126" mass="13426" checksum="E5EFDBFCF1FA4639" modified="2015-03-04" version="1">MAITQQNCSRAPSCGNCGSKNHSEDLCMATTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMKAFRQAGEREFQAVLRAKAAEESATSAEDFSVGKISSQTTEVDANANIITASPVDSSMGDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Z9</accession>
    <name>A0A0B1P3Z9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative eukaryotic translation initiation factor 2 beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Z9"/>
    <dbReference type="HOGENOM" id="CLU_026663_0_3_1"/>
    <dbReference type="OMA" id="CMREGNK"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="195"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="36594" checksum="D2D739BA8E8C46E8" modified="2015-03-04" version="1">MAQDERLRKAVAFRENETVIETNGEVRGEGEKNKPLQLSSTAISSESSIESKNITEKNQAPMQDSNSIDDVSNMLKSMKKKKKTQKPVEEEISAPIEDGGLDLSNMKKKKKNRKPKEAVEDEFAAKIAALQIDSKEGNNGATGSSAALEIYEGDVEKGTGLWQHNSEVKIPYDKLLSRFFILLAQKNPDHLSSGSKSYKIPPPQCLREGNKKTIFANIAEICKRMKRTDEHVTSYLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRRYIMEYVTCKTCRSPDTELNKGENRLHFITCNSCGSRRSVTAIKTGFSAQVGKRRRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P433</accession>
    <name>A0A0B1P433_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001427">
        <property type="protein sequence ID" value="KHJ33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P433"/>
    <dbReference type="STRING" id="52586.A0A0B1P433"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OMA" id="GTYAINW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="53870" checksum="4DA1E43A0E7761A2" modified="2015-03-04" version="1">MSDLSRELTAPNGKKYVQPIGLFINNEWVKSSDGQTITTINPTDESGITSVYSASAKDVDTAVAAARKAFQDPSWSDLPPTERGNLLISLSDLVKKHAHTLATIETWDNGKTIASASGDVKSVSEVLRYYGGYADKIHGQVIDTGPARLSYTIKEPVGVCGQIIPWNFPLLMAAWKLGPALACGNTVVLKAAEQTPLSILYLANLIKEVGFPPGVVNILNGYGREAGVAIATHSGIDKIGFTGSTVTGKEIMKMASGTMKNITLETGGKSPLLIFDDANLEQAVKWAHIGIMYNQGQVCTATSRILVQESIYDSFLTLFKKRVQEVSVVGDPFSESTFQGPQVTKAQYERVLSYIKCGKEEGATLVSGGEPFSQAKKDGKGFFITPTIFTDVKPSMKIFREEVFGPFVVINSFETEEEALKIANDTTYGLGSAVFTKDITRAHRVARKIESGMVWINSSNDSSFKVPFGGVKQSGIGRELGEAGLAGYTQIKSVFVNMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A9</accession>
    <name>A0A0B1P4A9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative argonaute sirna chaperone arc complex subunit arb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4A9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4A9"/>
    <dbReference type="HOGENOM" id="CLU_023193_0_0_1"/>
    <dbReference type="OMA" id="NKPTGFE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="66583" checksum="F11CF46DC3B2A866" modified="2015-03-04" version="1">MKSTLSVSSEFDSNHSKAALSMESPNEEFMRQEVQLSRAVSAVDLNASLTAMQEKPQKCFNRSQEETSNSQPESCQDTKLSNSISASGISTPLVIPNPPPPTPATVDIAVKSSDDALKSSCDIAEVIDVDVDQLASKKKKKKKKKNKTTKDDAGGQGKPKKKPVTGFEEFFADAPIRPDEYEEELELYDQTREFKERMQTCIQRFRARRKLDPTRANIFSKFLALGGVETDAKQFNGGLDRELLENSTASEIAAFQATDFIRTYPYNPKYYDGSDKWVVDFEGVAKGFFSHRLPANFPVDSETQLEDYCMVIKGFLNYVLYHKVCPEYTADVLAARNIVDLAVKELWSIQRIASKLPGDFNKAASILFGGRYKNVWGFGYPEGEDSKNEDFTFTAGGFSQGRAEQIFMTAIAICGGTEQAAQVDCSEIFIMKTEKKFYEVIEIQHPNSHIIDQYNRIIDLNCKVGQIKPLGSVKLRYWKNPGVEQEDCTDEESDSENNELDFEWFWLEDEILQDFFLGLKLEVEVKELNIGMKYIDSFVGILCSFYTYLPNEKMVNYKEPVASTRPAPTEDDETIDEKYHDDFEIEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4C8</accession>
    <name>A0A0B1P4C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pentatricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001608">
        <property type="protein sequence ID" value="KHJ33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4C8"/>
    <dbReference type="HOGENOM" id="CLU_377682_0_0_1"/>
    <dbReference type="OMA" id="PPNIETY"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="789" mass="91344" checksum="D863AD3C7E8ECE6C" modified="2015-03-04" version="1">MLIVSSRAAPARLACRYNSCSQFATIFIHRCIGASKKKSLKAGDIFTAFYSTIFAAAALLDSKIKDNRLHEWDQLIAEAREGQWIGDEQNSCQSKYDRDFESSDALKSSFSITTTSESDNTNLNFFERPPWHLRSLKKKNIESFSKKSKLEIKDEEKFSKITNATSVARVGSFIGNFIHEEPDVDVPERDISDPKELDELRANINGLVCKIIEMSTIYRVFSKDGEISDNDDDDDDELQKQLEIMKQRLGSLNISFESLPMYNYEGTNDAKQKASDMNAILWCICRKAKCEEASLNLMIAKICYNLLISAVPPNIETYNIILHEFSLLGLHDFAEQVLQSFWFSRLRPNKRTIELIILHHKTRKDKIGLNLMVKKMRGANGNLMQSSVYAKKYRTKFVSLDEPHQVLQNFDPRNPVIRRGMKKKKFYFRSGYLYKKSPRDKHIFDALINAQFELKGLRPAIRYISAAIREGSKIKASTLCLVINSCIKRADFTSGLDVLMIILSQWSLYGYHEQIQLSAEVRFHIYLLLFFCGIDPNKGVNGHLPSRIIKYTESMIIREIEFPKEALRKLLYLMKIESLKERLSRNSDLILKLANALNYGEAFSVNPKTYDQDAIEIAFRVIETAAKTEKEISDAHQYSIDLRVGFKLRIRGLQSNYITTCSKMEEITTGLIMIRVRMCASKLNFIANMILHTELYEINMHYLQNLDSRLRLLHMQVRIEAYLNKWWIRRFGFTSSLSRSCTQRKRLNHIAQILTNIELKIKSLWDRHVLERCSPDKHYDTKNSDYSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4J0</accession>
    <name>A0A0B1P4J0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001579">
        <property type="protein sequence ID" value="KHJ33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4J0"/>
    <dbReference type="HOGENOM" id="CLU_2575625_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="81" mass="9185" checksum="90E3252784DB66D1" modified="2015-03-04" version="1">MPSSPPLLQAESPTTGFDFYHLLYPSISSILPSIKQERFNVRAQCRKHTLLDHTFGPNKLLKIKNKVSSYSLTVNRLPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4L2</accession>
    <name>A0A0B1P4L2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01002733">
        <property type="protein sequence ID" value="KHJ31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4L2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4L2"/>
    <dbReference type="HOGENOM" id="CLU_049331_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="13">
        <location>
            <begin position="78"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="268" mass="30568" checksum="873A57588A275B7F" modified="2015-03-04" version="1">MNNEKHIKSILKKTNNFTVEKKDRNREIAIHHANIIQQRKNFELEILFSIETLIDYPLAPPPADASNPSPIDISKFRQLVQSFQPSDYDSLIEERNINDRCGYALCPNRRHKEVGGGKYRLQGTSGKAKYFRVVEKEALEKWCSNTCALRAMYVKIQLDQLPAWDRGIIKEETYVDLLVGPTAKELNVHNSSSNTSSISDQSTIADDFHCLTLESRDNILESKIGPALIDIKDKQVKKLAQHPQFFGNTDDNTLHLNLEGHKTNFKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4N4</accession>
    <name>A0A0B1P4N4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002515">
        <property type="protein sequence ID" value="KHJ31876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4N4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4N4"/>
    <dbReference type="HOGENOM" id="CLU_008177_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="387"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="749"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="896" mass="101027" checksum="2AD9A4F8AA1951D2" modified="2015-03-04" version="1">MPDLEAKIEVPDALSLNSKNSETDQSDNETDTYEDASDASLTEPSAGRHSSTELSLTEHSKLLSPFLADAFDTKDIIQQYPIPPPAHDILPEANEKIEFCSSSPTTKSYSPKSSIVRISNGYSNHVNSDEIKSEENSPKQSSSEANSQPSSVTFPTFKYPVFSRLSSPPRTSSLHDSANILQSIPALQPIQSIPPPPTTARKLTSPFLWLSRNLGKDFSPSEAISSPKFSARRGTISSIFTNGSNQETSNNIDQTHELDHSNLTKSSIKSNLKDRFKVLRMREEAGIQMIPDDCEKKNDGSGQNIQYSDLSNKDDKSKDIAEKDNPPSALVSPVSPNSILSPSVSMPASSSTSSSVDWDLWQSVVDEGPAAVARTSPEELSRAIITGIPNVIRGVVWQILAQSKNEELESVYKKLVSRGTEEDQQLRNESNESSNVVQITKSTNNKEEALTSSPSSSRSDYSIAGFSIGNGIRSPLSKEPETLDKVKAEKNKKAQDEIAAIIKLEKIIKRDLGARTSLSRFAASSGLQEGLFGVCKAYALYDEEVGYAQGMNFLAMPLLFNMPEDEAFCLLVRMMNQYHLRDLFTQDMPGLHMRLYQFEKLLEDFEPALYCHLRRRQVTPHLYATQWFLTLFTYRFPLQLVLRIYDLILSQGLEAIIKFGIVLMQKNASALLEISEMGALTKFLKDRLFDVYIDGTPSSVSILESGFFGSSGSSIDKEVYRADQLIRDACAIKITPELLKKYALEWEEKNKLEKQRETEVENLRLSNKKLMHKVRRLEERIQDHDSEHTALATELVHTKVRNQELRDENESLKVQVDEYRDMMEKLPHEVEFRLKTEMDRILKRNQEVHDENTRLEEEMSHMEKTLVETKMKYAEINSAHETLTRKWVDLRRALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P0</accession>
    <name>A0A0B1P4P0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002704">
        <property type="protein sequence ID" value="KHJ31644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P0"/>
    <dbReference type="HOGENOM" id="CLU_405006_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="679" mass="76579" checksum="D8BACDBE6EDD42E7" modified="2015-03-04" version="1">MPFQYINENPTHELATSPTGSYSHAKVKNIPPFSAYISNIFLSDIQDHVDACNQIFDRGVLISHFPLYSPKMEYRSNLFHSNFNDSTRLIYDPVPSSDAVHIGRKYEETAPSQSPQNSKFAGNINRMAIEFQLTNDNIHATSSQTQNHKEVVKRTKDVNDKVTAPNTNPKNLLLLSAYVPDEFVYYDFENHINNESNDPVKTLATHQGVNKVDEPKCSLLEDVLTRTDVSSLINIPKVSNSPILNQCSTAAQNIQPCPKAEDVESLGLTSHKALPINPLEMAKENTRNNDCPYAPRPRKIRRAFKKIIPTENVEQFLSNPKSLSYDELYHRAAAVASLMVELQDEARVIDKELNDFEVARKSNHQISIEEAKLEKELKQREEDIVFEAMLKKYGNLSKLSVDDWTSFLKNFYDCYLDENPDNYRLLLYLRNHQFIQDFQKRKNFREKAKQKANAVRLADTIDSPPSKMEQKAMEESDRKKRKPAIDPLIFEDRKMADVYGLTHKNGDAFIGNQPLRNRNGMQKDLSSTNNIDDNFRPKRARGRRGNNDTDHSDHTPVVSDAEDVAPTKRARISRSGLDSTASSRASAKTVSSSRESSPGAGPKIFASGKRVGRPPGSSKTQVKLPSKLKSVQAAGETTGKNRSEGIEEVPSIEQSNLISKIYVDRNSYVIFSNNGNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R8</accession>
    <name>A0A0B1P4R8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g6138</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4R8"/>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="297"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ33692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="60535" checksum="C3581597E900FC2C" modified="2015-03-04" version="1">MSMETVSFNPFSDQKPGTSGLRKKVVVFQQPHYSESFVTSIILSIPEGYEGSTLVIGGDGRYWNLEVIQLIAKISAAYGVKKLLIGQAGILSTPAASHIIRKYKATGGILLTASHNAGGPKNDFGIKYNLSHGGPAPESVTNKIFEVSKNLTSYKVALIPEVDVNTIGTNKYGPLEVEIIDSTADYIHMLKEIFDFDLIKEFFRTHPDFKILFDALHGVTGPYGCAIFEKELGLPSSSVQNCIPSPDFNGGHPDPNMTYAQSLVQAVDQGNIPFGAASDGDGDRNMIYGAHSFVSPGDSLAIIAHHAQLIPYFKKQGLYGFARSMPTSSAIDLVAKAKGLDCYEVPTGWKFFCALFDANKLSICGEESFGTSSNHIREKDGLWAVMAWLNIIAGIGKDNPGATPSIAKIQHDYWNIYGRNFFTRHDYENVCSEGAAKIINDLGEKVQDDSFVGSKIGDHVVCEANDFSYTDLDGSISSNQGLYVKLSDGTRFVIRLSGTGSSGATIRLYIERHTTDAETYSKNAQDFLKPQIHMVNDLLKIQEYTGRERPDVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P523</accession>
    <name>A0A0B1P523_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002081">
        <property type="protein sequence ID" value="KHJ32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P523"/>
    <dbReference type="STRING" id="52586.A0A0B1P523"/>
    <dbReference type="HOGENOM" id="CLU_1361314_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="22308" checksum="FACCE5DBEBF1603C" modified="2015-03-04" version="1">MTSFLPTVGSKEHLHLAENFRCIKRPKNDKKRQVFSSAEVQPQFSNFHSTKNSYSATVLFEKTSSCKSGQDVGDTFSTNNVYLSNDGDNGPDFTHFSNKVSNKDDRLGVRVNETINRGYLAIGLGASSLERIRSNLLRDNRANSGKEICNGSKAYPDLSNSSEESPPSLSIVVMIIGTRGDIQSFLKIGKLFKNMDIKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5D6</accession>
    <name>A0A0B1P5D6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5D6"/>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="229" mass="24944" checksum="CF7EEC68EEFB6F8B" modified="2015-03-04" version="1">MEFGVTGNLNEDGIHVDMECLKKGEVNLGTSIMAVNFKDGVILGADSRTTTGAYIANRVTDKLTQIHDTIWCCRSGSAADTQAVADIVHYNLGLYGIKNGRPPTTQTAAAIFQEICYQNKNRLKAGLIIAGWDERHGGQVYSIPLGGSLHKQSYAIGGSGSTFIYGYCDKHWKEGMNEDEAVDFVKNALQEAIKWDGSSGGVIRMVVLTAKGAERHLYLPDTDYLVRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M0</accession>
    <name>A0A0B1P5M0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01001936">
        <property type="protein sequence ID" value="KHJ32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M0"/>
    <dbReference type="SMR" id="A0A0B1P5M0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5M0"/>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20813" checksum="446AAFA142F1208E" modified="2015-03-04" version="1">MRTKPNLIITGTPGVGKSSHCEILAQKTGLQHVSINDIVKDRGCHEGYDEKFKSLIVDEDKLLDSIEDMVKAGGCIIDWHACDLFPKSWIDLVIVLRVNSTLLYDRLKARNYSETKLQENLDVEIMEVLLQEARDSYDKEIVIELTSDSIDDLDSNIERIESWIAQWIKDNSEKMTENISDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P624</accession>
    <name>A0A0B1P624_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001025">
        <property type="protein sequence ID" value="KHJ34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P624"/>
    <dbReference type="HOGENOM" id="CLU_151460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="13207" checksum="3EC936E5073E1D12" modified="2015-03-04" version="1">MRQVYRESFLLPVKSKSSPSHGAGVNAQYALHVWDSQEDSRNPSFPSGSPIHHRRSQSSSFLYHFTLSTFFHEPPHDWPREYRVKGSILSQRTSDESKLLAQMVGCWLDFLEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P647</accession>
    <name>A0A0B1P647_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g5902</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001260">
        <property type="protein sequence ID" value="KHJ33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P647"/>
    <dbReference type="STRING" id="52586.A0A0B1P647"/>
    <dbReference type="HOGENOM" id="CLU_118180_1_0_1"/>
    <dbReference type="OMA" id="WAVINEQ"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="100" mass="11391" checksum="0E22A546328D093A" modified="2015-03-04" version="1">MESGEPNVMSLTLRSEYSDDLLTPLEQDVIEEYERLARNMSKFASVLKDMGEKPITEVLDGLRQLERKTGLVFTLLKASVYSIVLQQEIYSGDAQHQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P680</accession>
    <name>A0A0B1P680_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001803">
        <property type="protein sequence ID" value="KHJ32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P680"/>
    <dbReference type="STRING" id="52586.A0A0B1P680"/>
    <dbReference type="HOGENOM" id="CLU_696755_0_0_1"/>
    <dbReference type="OMA" id="RMADENQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="396" mass="44437" checksum="454FDAEDE888A7BF" modified="2015-03-04" version="1">MLTFQDSDDEPDDIGNSSYSQEKGSSILGLNWDKKAINKSSQLDKSTILDWDSFKWKPHPSSYLKGISNWSAYKDALLLQLECVGYEAGIKLTRLDELKLAAVIQRTTMPEAGALVSGMKSGTNMMRLFEATYQQIGEVQQESLWEAILAVKYTGACPVEYVTKFKTSVRSYKNAGGELGPKQISTLFKQSVKEKAGRWHGIVTALARFQSWSTEQLYQDFVSHHFERIGRQERRDKNASFKEPIKKSLNNAQDSNLNSDSTSKKGFSASKSNKKVRCYKCKEMGHFSSNCPKRSKKGVNVTQNSGAVLVKDLDPPQALTGEYCTIPEEEANSYNYMHQVDHRVYDSMVTFVESELARRRGESVPIIEPLESENPGAEIKFTQQVLSARSDGTAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6A4</accession>
    <name>A0A0B1P6A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001780">
        <property type="protein sequence ID" value="KHJ32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6A4"/>
    <dbReference type="HOGENOM" id="CLU_2238617_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="105" mass="11417" checksum="CA795723F34AB6D6" modified="2015-03-04" version="1">MGLAIKIFIFTPAVAISSKKEDIFNAELASLWETFLYNIWGFHARTKLIIKRTMILMIMSGVSTFLQTFMTIDGVEFIGSIAFTALSISASVLSCIALGFVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6D0</accession>
    <name>A0A0B1P6D0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g2741</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001741">
        <property type="protein sequence ID" value="KHJ32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6D0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6D0"/>
    <dbReference type="HOGENOM" id="CLU_006200_1_1_1"/>
    <dbReference type="OMA" id="MMHYFFR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="795"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="902" mass="104097" checksum="6E17CDA1A72F37A3" modified="2015-03-04" version="1">MLLSHCNMLSPNILSHILPTRATRRSIYEELRAHDADEHGSDIEAQTRLTLDEENLQLQGHELDYLNMTDDRESPNAVESTHLISHSNSSSRAENVYKGENKITQPKWMIQSPRFLPDDGDEDVPASLLVEEQEMTGPSTIKNIPKKPTKAKKHSAQWEFSPTQKKMQANIIGKPSRKIGFVTSNAREKALWHWINITNLDNFIRDLYDYYTGAGIWCILLERTLNLVQVVFVASFTTFLTQCVEFQNIPGSKKLSEILVPQCTKKISGIASLAIWLFTFHVFWRVCQLIADIPHLLRVREFYIFLLEIPEIDMQTISWQDVVARIMTLRDANPITAEDIPPSNRRFIGSQSKQRLDAHDIANRLMRRENYLIALFNKDILDLTLPIPFLKARQLFSRTLLWNIDQCIIDLVFNDEGQVRQVILKESHRKQLSDALRRRFMFAGFMNALLAPMIIVYLMIVYFLRYFNEYQKNPAAVGSRQYTPLALWKFREFNELQHLFEKRVNMSYPFASRYLDQFPKVKVTQVARFVAFCAGAIVSVLAVLTFWDPEMLTNFEITSDRPVVFYIGVLGAIWALTNGMLPEENLVFEPEFALQNVIDYIHYMPNHWHNRLHSDDVKTEFAQLYKLKIVIFIEEVFSIIFTPFILWFSLPKCSNLIIDFFREFTVHVDGVGYVCSFAVFDFKKNGRCKPREQASRATDAREDYYSTKHGKMTASYYGFIDNYLLNPRSTARGHIPLEIRQKYYPPPPFPGLMSPAFAPEIQNSRVGRSIKRHGSCASQLRPINKHIISPLHSILLDPHHQPSNSGSGRLTSRHRNRTRQIISKEPAGAENQLRFKSERNIPKSQPYESVMGLGESRWETSPPRTDISKAGEEDEDLTSAGVLGMLYQFQRTHKDGKCGVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6V0</accession>
    <name>A0A0B1P6V0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001908">
        <property type="protein sequence ID" value="KHJ32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6V0"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_2_1"/>
    <dbReference type="OMA" id="WSEKHEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="27834" checksum="4C3E7D6A518D367A" modified="2015-03-04" version="1">MDKGYYPACWKKATGAVLRKPGKPDYSQPKAYRVISVLSCLGKISERIIAQRLSYLAETSDLLHDSQIGGRLKKSAIDAALLLTNEIQTNKNHNLMTSALFLDVKGDFDHVVKNQLVEILKNKRLPTNLIAWIASFLSERELRLAFDGQSEHFSKINTGIPQGSPVSPILFLIYIKDLFASRAVKIIAYVDKICLIAASKSIRRNIKILEREAAQLYERGDQNDIDFDLAKTELIHFSRSQEAKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P764</accession>
    <name>A0A0B1P764_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative serine threonine-protein kinase psk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001055">
        <property type="protein sequence ID" value="KHJ34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P764"/>
    <dbReference type="STRING" id="52586.A0A0B1P764"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_37_1"/>
    <dbReference type="OMA" id="IFRKIDW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004711">
        <property type="term" value="F:ribosomal protein S6 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="163"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="425"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="523" mass="58733" checksum="12EC4DD6A3A3DF41" modified="2015-03-04" version="1">MTSSIPALNILEDTKTPKVSYKDLGLKSKSSKKRHKIDDVVSSNSSPSLRPTQYSGLGGISKLRLKLEEINLNGQSSKLASGNARNTADQLSKFSSGVTTCTTSEIEFSDDDEDDRASDISNCNVPPNDNKENTNCVIQDSEIFAAEEATKQKCNNQIRPSDFQSIRCLGKGTFGIVHLVKQHTTGRLYAQKQFKKASLTLHERLIQQTKTERTILESVKRHPFVVKLFYAFQDDEKLYLILEYAQGGELFTQLAKARMFPEPVAVFYLAEMVLALDYLHHHLGVIYRDLKPENCLLDSEGHLLLTDFGLSKVIIGENDRFNSVLGTVEYMAPEIILGHRYGKTVDWWSFGALGFDLLTGSPPFKGQNQMKVQERIVKQKLQLPHYLSPDAKDLITRLLRKEPSKRLGANMPKDISTIKKHRFFRKIDWKLLEKRQVLPPIRPVITDPELAENFATEFTSLPISPMISRDTQWNKEKTSSISISQEKPIENPFGGFSYIASPSLLEGSFGGGQFAGLGNEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8J7</accession>
    <name>A0A0B1P8J7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000571">
        <property type="protein sequence ID" value="KHJ35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8J7"/>
    <dbReference type="HOGENOM" id="CLU_107277_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25101" checksum="9BC9744A83842154" modified="2015-03-04" version="1">MKGNQIISNRVGIHINELEKVHRAVARAILPVYRTTSTAVLYRESGLGPAELTLDSLSRRAALRTYRLGSRHPLYQKRHKLALGPAKTRLARALETIPPSEEIDPLSNPPWENYNIRENILMTGLDFSGPPNMRASTFNEFLNKLPRSYKLIYSDGSKNSNGNLGAGFIIVKMNTKLCVGAHPVGRHNEIQDAEAQAALHCTEFELLYHFQQAALPIIYGLSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L9</accession>
    <name>A0A0B1P8L9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000557">
        <property type="protein sequence ID" value="KHJ35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L9"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="OMA" id="NGHHSIK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="60201" checksum="406E34BFC4F3D594" modified="2015-03-04" version="1">MTDSMDITQENQALSTDTSNKPPPIPLIPPIPNPLPPIAPPTPPSNSQLLNSTTSSRKILIPAIPIKRPIPERSQQKNKDRSDIANAFLPQELSEVVATRQRRERAWNARIMICTTVYSNIESNLANFSDEIQKEEVIAFKAYLRQAIANFAAIDNSPNPPKIPSHSKPTKSCGSGSGRSKNVEKNVPVAITQLPKPPQALQNTWVTVTRNGHKKARATTNSNVNITPMRKIRPRESRKEKSPATPDKRLFLRLPQEHEWRKLSPAGIREIIVKKLSISPTLIGRIKPVHLGFSLSPCSTEAREKALNARNGLFLTGAKLEEATNWATILIPTVPAVIRKEQREVEVSNSMLADEVERVYSMRPAHLKLFGGNKTEAPHRTWMAVFPKAPRGSFKVFDESGIARPFKKQQPLEFSKRCNGHHSIKNCSRAPSCGNCGSTNHSEDLCMASTKCRNCGGPHRSDNRRCLARPTRSGAPTKEQLKTYRQAGEREFQALLRAKVAEESAAAADNSNSNVISSQDTDLDSNIDNSQASSVGNTMDGAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N2</accession>
    <name>A0A0B1P8N2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N2"/>
    <dbReference type="HOGENOM" id="CLU_018395_1_2_1"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="43711" checksum="BA1B326679D396D8" modified="2015-03-04" version="1">MGPKKIVKEEKILLGRPGNNLKSGIVGLANVGKSTLFQAITKCHLGNPANFPFATIDPEESRVIVPDERFDWLCEKYQPKSRVPAHLTIYDIAGLTRGASTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHIEGDVDPVRDLTIISDELRIKDIEFTEKALENIKKQTRRGGQSLEMKKLLEEQACIEKVLALLNSGGDVRKGQWSSKEVEFINPLFLLTAKPVVYLINLSEKDYIRKKNKHLGKILEWIKDHAAGDPILPISICLEERLTRFESEKEAKEELQTLGVESALPKLISAMRKVLNLGSFFTTGPDEVRQWTIRNGTKAPQAAGVIHGDFEKTFIQAIVYNFSVLKELGDEAEVRAKGKILTKGKDYVVEDGDILLIKAGAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U2</accession>
    <name>A0A0B1P8U2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001496">
        <property type="protein sequence ID" value="KHJ33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P8U2"/>
    <dbReference type="HOGENOM" id="CLU_000893_1_0_1"/>
    <dbReference type="OMA" id="MKANFFV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1383"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1631"/>
            <end position="1925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1941" mass="219147" checksum="523314886368D1D7" modified="2015-03-04" version="1">MASRTRGLRRQALQKIGVLAAVTAAKKKTAASHADLDQLFQACSLYSKSKSRSDGNSKKTLELQSNLQQYMSIREFEVILALCKAAQYFSVLNQNEKLVSFLSPYILEAYMQAFEPSPFFRDIEPSPIESLSFHLTSALLLLGAKKNNLQENVKTDIWVYLNRCQEASKTLSYPRPGNSTELKNAITIATITLSLLGFLEAATIHADLWSPTDRLSLVKLFRAMFAGDFLVTIETAFSTIRNTHVSEHYIKEWKQYLRHYSSIGRPLGAMLVQKSFMWLMVATSSLLSADIEYEQLLDLLDLRITGRKPSSNNLPHHLGAVECETIEILSDIASTELTDLEDGVDYLRLGRKHLAFSLKAGALVCFLNCVTFNKITVEVDVLISWLESTLADPIQMADKMLANIVLRSISLVSKLAPQFASNVSRLLPRFIVNSRASSQVITAASSCLAYVLQLLSQDAVITTIYLLGNDLSLGTTNDKNLSNNLTAEIALSKNGQTIVDQEKNSFGSSASLLNSTGEDINIVHGNVVEAICTIAIACNDTKITALAQSMLSQRFEKINKSIDARIIIETSRLALSGGSLEFRSLLKLYARISTEGILHKNEALLLAVSEGRNHLSLSLGKDSPLFEIYFRHLLEAIISKGDLHQGENKHEADVEFAAQEISQLLQPLAILMSHNNMASEDNFDEEILSLVRDAWFNIIIHGFATNGERRKKHLKELRLIAAHSKPLVTEQRGEQIESDIELNTVLRRGSSSDYEVKIKRQLLSLLPSRASEIRGMSYRKIIFLHATYLIESLRAETGDCTQALTYFLEPSMRKGDMSITMEAITSAVISKYLTKTLSGTFLPFSSPCVSKQLALIFCHCCHRIDRVQQAALTCADRIINEVPSALCQKDSLFALLELLTLMWTSCLGAQIDEYEWRSSFSSARANVTVELSDDIGFRRRTLNNLYMRAKKWVISVINIAPLDVKGLLQTYLSEYDDYGVYNYVSLGRSFAIEMGSLIPSSDQRLQAVDHQGDCNINTASDFIAQYTTRQEYRQSGPQIHHDFEWLHLPHCLSPTLENNLDFEDATTILACLETRLREHKSVSLVELRDILRRAASLLYRANKDECTIAHYLVSIPFVLFTKSSIKLGISLWLGVLNENPRMESRLLVEIAQQWELTIYQRRGVFCSDFLHSDPFNNKMEFAPSDRSTVTKKVRRAQGLLAPHMILVQFLSSHFNAMRLCNENTEKVFLRILDTSLKGLNHATAHPLAREIRFQVILLSLNILQNCANLNNQTKSNFKDNILSAALAWFSHSPRWSYGGNRLQIKAESILLHDVSVALQGVKTNSDSISVSKLKNIQSKQSLLQLLIDSERQRINVWLYPLVEPQNIHNLASPGKAFTEATLIGLIKTAWNESPSLAVQLFMRFPSTKLHREIRLLLLKFPEKATSNPEAIQSLLGDSLPDDVSSQLKYLLYWEPVNPVSAITYFLPQYRNEPYVLQYAMRALESHPVDVTFFYVPQIVQALRYDTLGYIERYIIETAKISQLFAHQIIWNMKANSFKDEDSQIPDSLKPTLDKVMSRMIKEFSKNAKIFYEKEFAFFDEVTSISGKLKPFIKRPKPEKKQKIEEELRKIKVEVGVYLPSNPEGVVIGIDRKSGRPLQSHAKAPYMATFRIKKSVSIREETDGMSEDFDNQENISQENSIETWQSAIFKVGDDCRQDVLALQMIAAFREIFQNVGLDVYVFPYRVTATAPGCGVIDVLPNSISRDMLGREAVNGLYDYFVSKYGNEDSLRFQEARSNFVKSMAAYSIISYLLQFKDRHNGNIMIDDAGHIVHIDFGFCFDIAPGGVKFERAPFKLTSEMIAVMGGNTDHQIFKLFEELSVRAFLASRQYTQQLSQIVLLMMDSGLPCFKLETIKNFKDRFVLEKTERDAAEFMKGLIKASYKSYSTGVYDQFQLLTNGIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F4</accession>
    <name>A0A0B1P9F4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000446">
        <property type="protein sequence ID" value="KHJ35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F4"/>
    <dbReference type="HOGENOM" id="CLU_1504545_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="179" mass="20099" checksum="04B03CEBD887513E" modified="2015-03-04" version="1">MLPKNSGKCLKRLNTRKGSRTENKTKTKAKISADSVSVKVDNKKAYSRETLTQSDFNIDPKTIFPRVNPEHKAFHFVAVLRGRYDEKSRWKKVTLSPGISQADQGSELSIISQGLVNAMAFPRYTLSREKDDSGLFVSTADGGATELKEFTCFNVGVSGIWRRVYAFITIQENVQRQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I1</accession>
    <name>A0A0B1P9I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative vwa-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001097">
        <property type="protein sequence ID" value="KHJ34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9I1"/>
    <dbReference type="HOGENOM" id="CLU_006368_0_0_1"/>
    <dbReference type="OMA" id="SEAHWAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="597"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1132" mass="126218" checksum="6586C39656154575" modified="2015-03-04" version="1">MSKLFRRSISYREPPDKFSELGNKQNSEPYPLPGPKSISISNEKHLKRSQDSARDSESRTPEPQLRRTSGLSGSELRRHRRKSIIDALRPNSSQQNPDKSSLKKSASNFSEIMDSDRSRTRRERTFVGSECAVCEEPLEHTLRGERVLQFSCGHVSHEACFYEHIKEFEAQYCPSCNAPLGLDTSRGGNVLDIEKLSNIVRSVSANEQHRMSQNIGPIWDNQSARPSSRDSYSRQIRRDERPFDNYESRDRISRQLMAPKLGHIRHSSDNTHSPSVGYSDTIVSVSQARYDYDRQISELGVTSPALSSLRNPIPSPNVVVRPEFPTLNRSREQQSLTCIVTVEVTESNWRPNPEDLRRIPSPTPPEETFTRPPSPAHSVPRQYSFHSPEELLEITEKLRNRVENWHGLDFSRFGKLRLYGKIRVGKDKVSWQELECFLFAEMLVCVKEKKINLPQWDDPNSTQKATRCTLKGSILIKKHLNEVSRSSHGDENVLTLSLSVAELPFFHLRFENINDLKVWQHALLGLNASEVSMARSPDYETLEHEEEVWQEVTDAIIPKRISSAQSYGGIQNVNTANETMNNQKILRPHVATHVPLDIVVVVPITSSMQGVKINLVRDALKFIVQNLEERDRLGIVTFGSSSGATPLVGMTSSVWNGWAEALSSIRPVGQKNIRADVVEGANVAMDLLMQRKFNNPIATIFLISDSSATDQETVDFVVSRAEAAKIGIYSFGLGMTHKPDTMVELSTRTKASYTYVKDWMMLRECLAGCLGALQSVSHQNVKLKLRLPEGSPAKFLKISGALQTIKRATGKDAEASLGDLRFGDKRDILVQLIIMPDQNSQEQVPQDPWESIVSGLEALGGPDKEDERVLSVEEVPLIQADLSWGDILREGTVSHLPRPSLLAITMFPIPAAQEKKNTSCSVGTPPIPPLPNVVQRRMELLTSDMLNRALSLVSRGQHERAQHLLTETRSILKGLAKGSLPPIPLTSKNPKSNDSNLPLPSESNGATSPKLTSNLTRIPSQSGTSGSGFSYSLSDACHATTSAGIDSNIVPPLDVELEASLEWIGHPAVFSRDSRKSILQAIGVISSQRGYTFRTPIETLWASRIRGVRIMTELSKEWREEAGGEGGIMEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N1</accession>
    <name>A0A0B1P9N1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N1"/>
    <dbReference type="HOGENOM" id="CLU_1273092_0_0_1"/>
    <dbReference type="OrthoDB" id="3597760at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079851" evidence="2">
        <location>
            <begin position="27"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="24081" checksum="903A9E6EE602ACDB" modified="2015-03-04" version="1">MLGIQLNRPTKFQTFVVLLLRSAVSATPSLTNPEIISSLLTTDNDSNHIVSPQLNSTSQVDYYTDQRSRVFKCYFVIAAIFFTSFCVLCLYLQHRRKIRATLKKRDAEDTGSRARVNAHMTLPNSIGVSNDPQEPRNLQDNLYEGLDAHGEAPPPYAQTSKPPGFREVNGIIASPVTAGVTNTEQQFSSEEPPTYNEHVISVQNQNLGDTSATRPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N4</accession>
    <name>A0A0B1P9N4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000418">
        <property type="protein sequence ID" value="KHJ35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9N4"/>
    <dbReference type="HOGENOM" id="CLU_005922_0_0_1"/>
    <dbReference type="OMA" id="PFVHTYE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="372"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="655"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113824" checksum="94AF1E93BA3EDE7B" modified="2015-03-04" version="1">MLHHDDLIAIAPSIDVKSPIKSILCECENLVKLSNVSLEFGRPDIALQQHLQASIIAIEIIPQHKEFCDLKYDRLELYKLYSSLTERIKSQNAKFMEAKQIIKRNNLLHGTQPNSSKGKSQNSYHSEFLAGVTENGRAENVSLRKGIVNNSGKSGKIPPPIQPKPKALYGKAIQASNSPDSQHQNLDLAARFARLRSTEPNSPKQDPRIRTQPIPTAAGAILNTKSNYKTQTIASSNGPVGPRDMPCVPTTKPQINAAPLHVIIPDLPRAPDAIYSPARGTELTNSTNLLSSLRNNLHKSNVQHNAPPVSQATPTSIKLNSRNNSFSLIRRTTQLADTSEDQRDIKVTLLVSNYVTSEELVKLLAKGTQSLNILLVDIRSREAFEIGHIMSQSIICVEPITLRREISGEELADSMVIAPDTEQAMYERRNEFDLLVMYDQSSTKITDNDKLIHFTTAVYDYGFEKKLKRPPLLLIAGLDGWIDLLGPNSLATSATGDTVKSNQLEKKVARPLMRKLVHGSHGSLLQKQNRHYSRPLTMEQENIWASTIKEELAHNPHDHVDVDNELVYVRTMEDFIRRYPELPAVQESMIYSPASNLYEDQLVNAMPKPPARPAPAIPRQRSSGISEKGDSLSFSHSISNSDSTISETRRPVGLTGLSNPRVLCYMNTVIQGLSATPWFRELIKNYVHPANPPIPRREGESTDPPQLMVRCLSSIFAHLWFGQYEFINPTTFQGYVNAVHKQGPRGFGGTLVQHDCNEFLVMLIDILDDELNPLRNLPGRRPIEEIEGLLEKAPTILDAAAIYWTDWTSNLGSPITCRMKGVSVRVLKCDLCGKSRPVFDQFQQLLLAVPTDGTCTLNDILDANFGPKSELIEYQSLQCSNCCQNTSQKGRVFLVYMPDTLIISFMRMTNSLAKIKTRISVPLNVNFENNVVSNQEGSTNKDYRCKGPFIYDVYGLGLHSGNTLASGHYRMLARSLDQLAAGKPAGFWHMFDDRVVTPFNLTAVDPSEISLIFLQRQGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W3</accession>
    <name>A0A0B1P9W3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative s-adenosylmethionine-dependent methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001036">
        <property type="protein sequence ID" value="KHJ34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9W3"/>
    <dbReference type="HOGENOM" id="CLU_491074_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="61940" checksum="2E01876B99445125" modified="2015-03-04" version="1">MRTSSNRTSSEAKQNTLSSYGSRPNITRRITSQDAPHFSAPTNPNNLLVVGKNRAENEVPNRHSGHSYETSHQKEHLSNKSSNWHRNCQSVSQISLVSQEDSISGSINDQYSDLSCQQYYLTPLNQHPQLEAQHMAPSNSSITSRRAADTKLSLQLQQEARDNQSASYNRSQFSNHQPSTPGISPSFQGNQTQSHRPTPQKESYNGPQNEQRQNQAVLPTQERDINDNYKELVTKYKKVKGLYFEKTAQVEQLQNTLANQRLSQSRTSLDDSEYMTRLQRLEGAITNLAFNIRKDWQIVPGWLSQSVNCDAMKIGKHEMTAVGRAVITKFLVDEIFDQIFHPGLPMDISRNLKAIEKNIRNFSPAHNNHEESEALTARVVQWRLTTLDGLKDLLTPSESEVIKNQFIEGSTDNLSAVISSFLQEPNPPGINDSAHIIIELAVNIASNLPLESRDICITYPMPGSTLQPSIMKVENPIPSLGETIAGSEENESTQSGDKDENGNDKEGQGVLQAILGGNSSCKKVDDSSQIVRLSGFISVEVRGRQVLYKAPVWTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA52</accession>
    <name>A0A0B1PA52_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative duf775 domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA52"/>
    <dbReference type="STRING" id="52586.A0A0B1PA52"/>
    <dbReference type="HOGENOM" id="CLU_084839_1_1_1"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="26614" checksum="4A0B9A4CA62B03FC" modified="2015-03-04" version="1">MEPQPIIPQLFGLIPTGSPVLITPTTVPSPTSYTFNIPIPTAPRKPFSHLTVFLLPGITLPPSTAAAVYLALPQAPTEFRFLGAIGENKESAVFKISGLSDGTPDLLTNNSSGSNVGGVTEIDMDDMDEIAESTAAAILPTSEIVIGISIESAESVATQLAAIQAASLAKPTGSNAVVDATSQSALILNKTQPDILLLAQKIIKDAFNFVSSYSSSGSLGETVPLKIFEEWWKKFESKLKIDPNFLEKASID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA54</accession>
    <name>A0A0B1PA54_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ran-specific GTPase-activating protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA54"/>
    <dbReference type="HOGENOM" id="CLU_014536_1_0_1"/>
    <dbReference type="OMA" id="WDPYNES"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="78279" checksum="CA548838DCC3BC3F" modified="2015-03-04" version="1">MLVMEDFLAKVTQHAMNYAIRSGIGITASFAISQTSRLLRTVSDQTDYRELYTLQERLDSKIRIISPAIDLIELISARGNTTLESAVALTRALRWDIQSLGVRLEKAANAEEKSRNKNDRTSFLLVHKNEVEQIVNDIKRLILRIEDAVPLINLAITTSGVNLSTTLPPSVSPSRLLQASTFLTAGDSQYFISPGSHIQIGPTFTLTLYMLFAGHLHPLNYDEDGIRETTWKEVIHKAKVKLMRSSISGLEDDKLKQKGSDEFQAIPFLDPNAKNPESSPVNEYRLQNEYSYYLEIIEDLEDDRVHSQEDGESQPGPFGGVNLAGIREYFPIYQIGKIFYADTGKILNIGSMEEANRPVLLLKRDINAKPPRRMMDESEIHHEWHEDPEEKNIEIEEEPEIQEDANSQIRRESMGTPLGGNDELSPVYNSAWHLPAGLDPEWLAFEVYSENDQVDTEDERECNSSHSSEESNSSTETLTSTDLIEEISCLKITPDPSRSSSPLNQISPVKASSNPEMPSIVDQSPFGPIRSSLSLLEMLIRLTSLQQFQQASHLSIPDEILSFFLEESSTTGAGINDEERKRTRRDARRKVGFDPYDESPINRHGEEYQMNYSGRRNYHMESSPRSNGKRNSRFSQSQDRLNSPELWLLRNRSLNSSSTRNTPEYLPSSPLSYRSQKNKESPQERLHKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAF2</accession>
    <name>A0A0B1PAF2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pre-mrna-splicing factor cwc15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000302">
        <property type="protein sequence ID" value="KHJ35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAF2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAF2"/>
    <dbReference type="HOGENOM" id="CLU_068312_0_1_1"/>
    <dbReference type="OMA" id="KYREHGQ"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="26802" checksum="646F5A4C30850CBE" modified="2015-03-04" version="1">MTTAHRPTFDPAKGKEAQRGPAYHQRLLPAHTQLKVRKPGQGGDADRQIRDLRAELLQAEAAHYAKLKGAPIPALDGPQNDSAKRRIEDGKIDEGADEDPDIKRRRILEESRDIDADSEDEEESSEDDSEDEEDETAELQRELEKIKRERAERREQEEQEKAAQEEARRESDIARGNPLLNTRTAFDIKRRWDDDVVFKNQARGTETKVKKEFVNDLLRSDFHKKFMSKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAH1</accession>
    <name>A0A0B1PAH1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001294">
        <property type="protein sequence ID" value="KHJ33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAH1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAH1"/>
    <dbReference type="HOGENOM" id="CLU_001103_9_3_1"/>
    <dbReference type="OMA" id="CRWQFLL"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="261"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="469" mass="54231" checksum="AEE7DCEAD3E413F7" modified="2015-03-04" version="1">MSPLIKPDSCRDLEFILRRRFKKSTFRPLQRKVIEFALAGHDIFVQAATGFGKSLCFQFPAVIDHGITIVVSPLLSLMTDQVNALRNCGIEAGTINGMTSYEERQQLLQDLSTGHPLTRLLYVTPEQCANDAFRKHLKTVYKQKELARIAIDEAHCISEWGHDFRPSFKELKWFRANFPEVPVICLTATAIEQVRTDVISILGLNPSNLKVFTMTTDRKNLHYEVRFKNSENDHFHDFLAWIKAVHQRRAENKERRAELEEENQRIDNVSGIIYTIFRQDCEILASRLRANGIGAKPYHAGLRNEEKNETLRCWVENCVGYDVIVATTAFGMGIDKEDVRFVIHWQIPKSFEGFYQEAGRAGRDGKASACILYYSHEDRDRMFNRMNKDINDELYMIARYKSLQALVNYCEDTSTCRHQMITRYFGETEVPLCDYACDWHKDAEALKKAKNRNLPNNMSLSNQDCPLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB52</accession>
    <name>A0A0B1PB52_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000814">
        <property type="protein sequence ID" value="KHJ34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB52"/>
    <dbReference type="STRING" id="52586.A0A0B1PB52"/>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="11398" checksum="E5A295D7182F83BE" modified="2015-03-04" version="1">MSNSELAVSYAALILADDGVDVTADKLQSLIKAAGIDDVEPIWTTLFAKALDGKDVKDMLLNVGSGGGGAAAPASSGDAGAASATEDKKAEEKEEEKEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB66</accession>
    <name>A0A0B1PB66_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EV44_g1828</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000376">
        <property type="protein sequence ID" value="KHJ35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB66"/>
    <dbReference type="STRING" id="52586.A0A0B1PB66"/>
    <dbReference type="HOGENOM" id="CLU_008023_2_1_1"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="244"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KHJ35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="58870" checksum="A2D75A5CD9B3B21C" modified="2015-03-04" version="1">MLLKNISHSTCRKIFKPGINGKTSVIRLHWSTTFSRQWSSIKQPSWTSHAFKDAGDIKHEARKRSKTVAYISLGSNIGNRIKWIEEACNRISERGIRIRRTSSLWETKPMYVLEQENFINGVIEVETEFQPLDLLDQLQNIEKELGRTKIIDKGPRNIDLDILLYGNETVHHERLQIPHPGITEREFVLRPLSELIPQKPLFISSPWKFTQDYLNRLPMSNISTVTPLADGVEPIKSMKCDRKTQIMAIFNLTPDSFSDGRKNSQPLSNQEIINRIQVYLNDGASIIDIGGQSSRPFAKEISFEEEINRIAPAIHLAQHQKKIDSKATNFAISVDTYRAKVAEAAVRSGADIINDISAGRLDPEMLPTMARLGKTVCLTHMRGTPSTMTNLSQYPEGLIPTIAKELIERVEAAQAAGIRRWRIILDPGIGFAKNLKQNLELLRRLNELKDWPELQGFPWMIGSSRKSFIGTITGVEKPVERIWGTSATVTAAISGGADIVRVHDVKEMTQVVRISDAIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB82</accession>
    <name>A0A0B1PB82_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0968</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000369">
        <property type="protein sequence ID" value="KHJ35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB82"/>
    <dbReference type="STRING" id="52586.A0A0B1PB82"/>
    <dbReference type="HOGENOM" id="CLU_018823_0_0_1"/>
    <dbReference type="OMA" id="DIFRAPY"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="15">
        <location>
            <begin position="341"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="131"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="566" mass="59654" checksum="24CDBFF351904B6D" modified="2015-03-04" version="1">MESKSNPTGGGSNIFGQNKSLFGVPASQNKSPLFGQTSTASTGAATETTNNNSQGLFSGISTSKPETSSTQSLFSKPTGAATGGLFSIPSTSGGFNFGGNSASTLGTENKPVTSFAPSFGGLQAKKTLVPSTSTTGEVSGGALTPAKPFSFNASTTPAGPPPKNNISGSSLFGNGITSSESKLSGNGSESKSLFGKGSSTLFGAPKSNSESNSSAASEVQKPSSMTSTNTDVPSSVAQSIESSSTLKAPLSSEQTSSGSSSKPDIFQNLSNNTTSSAPTTTLNSAAFSFPSAVGTKRSAPASKNTTSTENLTNQTSDTTTQAKTTTAEAEKSVNAPSFGSSTVGPTPQLTRLKNKTMDEIITRWASDLSKYQKEFQEQAIKVAAWDRLMVENGEKIQKLYLSTFEAERQNTEIERQLLNVENQQDEVASWLDKYESEIDEMFSRQIGQGEIVQGPDQEREKTYKLAEKLTDRLDDMAKNLTSMINAINDASTVLSKTGKADDPLSSIVRVLNNHLTTLQWIDENAEALKSKIEESQKVGKNIGSNGLKGLESESADYFYRSLMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBA5</accession>
    <name>A0A0B1PBA5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001139">
        <property type="protein sequence ID" value="KHJ33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBA5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBA5"/>
    <dbReference type="HOGENOM" id="CLU_000288_79_2_1"/>
    <dbReference type="OMA" id="YICVEYM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990315">
        <property type="term" value="C:Mcs4 RR-MAPKKK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="257"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="637" mass="69485" checksum="7514A9E8A0FDEF4E" modified="2015-03-04" version="1">MAEPSDISSYATECLRDLALTSESQGIVENEIYPVPQITQSNYHRSMDNRSNSSPDIINSSSAPSTHIDLVNSARRPTFPVSNSNFRSSLNSNNGALPESVEAKMKSFLLSRQGTPNRPLMSAPLFPSSPNFPSSIISGSPADLRVPINQRPQPHNIVSAPIVPMMPNKGGLSARRGMKILGGLPGISNPSSPPTKMTLNNISDISKEERPPTMFNKFSEYVDTKNGTLKFDGKAVIHGHGIDFTSGSNFSISLDEVDTLEELGKGNYGTVYKVRHARPTVRRPGLGLAGCRVPSPASLINSVEKNSVTPEPLSRISNTTSGVVMAMKEIRLELDEAKFAAIIMELDILHRCNSPFIIDFYGAFFQEGAVYICIEYMDGGSIDKIYGNGIPENILRKITYATVKGLQTLKDDHNIIHRDVKPTNILINTRGQIKICDFGVSGNLVASIAKTNIGCQSYMAPERIAGGGLAQTGSGDGTYSVQSDIWSLGLTIIECALGRYPYPPETYNNIFSQLSAIVDGEPPALPKDSFSPQICDFVRSCLNKKPMLRPKYSMLLQHIWLAPFSMPETISEENEDIEVSGDRESSNFNDLTKGDKEVADWVINALEMKKIGKIDEIIKPALHAAPLNRFDGKSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB1</accession>
    <name>A0A0B1PBB1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative nf-x1 finger and helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBB1"/>
    <dbReference type="HOGENOM" id="CLU_001490_1_1_1"/>
    <dbReference type="OMA" id="APCQEPC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="10">
        <location>
            <begin position="1865"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1604"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1939" mass="221095" checksum="985A891F0EAAB579" modified="2015-03-04" version="1">MPPRSFRKERTKIESSHHGCGKNWIANNEKSSERNTKSDTGQVETSEAAELKHLYYNWKRMIKSKPNHKNNPFTIKNLWDNACKILDGKNLELKTRVPEDLESTELFGREHITLIMELQAHDFGLKEYINLMHSFLKVVTHDVFLHCISVDTAVGGIYKFISGTNGTRAVLFFQHLCSSIINFLQCDSNLEYIDEILIEACRALQELLRREQKIPFNEDLPKVFGSIEDILEKSGTLEQSQTYQIVNQIITELRDIVNQAIKIIGNGKNDQSSRYTKKVVVSAYPKSIIGPQNRHDNDKLDISEIKILPTYEEIISEYTDFLPSTNLQVPHFIEERGLRHLDTHFRLLRHDILGSLKEALGVLISAIQKDPSQLEKSQLGLNNQIRVSIYSKVRVSSLSFAHKRGLELQISFPQPLAVKNKNLSQRKKWWLESRRLEQSTFLCLICCESNEISLLYLNVTEKSFKESQETLISSEYFATIKTRLVSEDEKDIKKLISVYMANLNSHFLIEIPCLMLATFVPTLKRLQDMYRLNSLPFRQWILSESTNANLLSDVIPPPIYAREPTFSYSLRSIQKHSIETEILVKPAISMGDEDLIEQIIANTLLDCSQAKALVCALCQEFVQIQGPPGTGKSFLGLNLMQVLLDIPSKYLIGPIIVVCYTNHALDQFLENLLKFGVHKIIRVGAQSKVEELQEKNLKVVAKTNASTKYERYRLYVANDLMEKKQNPVTQYLNELKNIRTNLSWNSVKTLLAEEYPKIYEQLQHLFADEYQFVQFAQLDPFDLWLQEDVENFEELCKIKDPTIPQLLELANKNIYSISNSGRRKLKDFWTFELQEKIADNLLEGFTDYKTAKQERSKILNEVERRVLQDAQVIGVTFSGFAGNIDVLQHVKAKVLFCEEAGEVLEAHFLTALLPSIEHVISIGDHMQLRPTINNFGLSLENSQGMQYQLDRSLFERLSLGENGVKKLPMAQLYIQRRMRPGISNLIKEIYPNLADHESVKDLPDIIGLRNNIFFLDHKNLEENKSEHGNSIKSYTNLWEIDMIFALVRHLVLQGSYNSGDIAVLTPYGGQLQKLRSKFQSEFEIILSDQDQELVKNGLFVEDNEHKDILNKESLEIKPSKKNISNLIRIATVDNFQGEEAKVVIVSLVRSNKEKKVGFLKTRNRINVLLSRAKHGLYLIGNADTYSRVPMWTRVIDTLKVQNSFGTSFNLCCPRHKSTPIKVESPLDFEKYCPEGGCKLMCELRLDCGHKCMARCHFETMHKIFKCHKPCERLHSPCKHACKKSCGEKCGLCQENIQEYTLPCGHKKNNVSCQETLTPEKIFCEFKLEKKSPGCGHIVTLACSDDVSLPSYRCIHPCKQLLSCGHHCIGTCGGCESYELGTRHEKCTKICGRPLSSCNHRCEKACHDGEECGACSKPCQIKCGHSRCPLLCHKTCAPCVEPCVWENCEHIPDSCQLPCAAPCIRVPCQMRCTKLLTTCGHQCPSLCGEVCPEEYCQSCSSKKDARVDLILLRNFDEINLDEDPIIVLSCGHFFTAESLDGIIGMSDVYETDKFGNYIKPKEVSEFAGSIPTCPDCKSPICQYTTKRYNRVINRAVLDEMSRKFLVSGQNSLKALERNVRDFEEELDKSICDIEEILDKFSNETDEKIFALIIAAQLKGLTKSHKISQERLSQKIKRFQSKFAEDNKPAKKLHDASIKMIKEKDLAKRFPNLNFEESRLIPSQDRRITVGAKILELDFRRVVLSYQINLFKTVKKSQFFYQNLIDLPKFGSIFDDCQALFGICLDDNLPRLAVQCTIYFGQLARHYQSFTHSNDSREERQIVNDQAKKLLTKGQELCLQPFQGSSELAIAIDETLKILGHDWYQEVTKEELETIKRAMVTGPGGIATHSGHWYKCELGHPFAIGECGMPMELARCPECGSNIGGQNHQAVAGVTRAEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB5</accession>
    <name>A0A0B1PBB5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative iron-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001135">
        <property type="protein sequence ID" value="KHJ33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB5"/>
    <dbReference type="HOGENOM" id="CLU_645902_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="47391" checksum="C09942159FDA7B76" modified="2015-03-04" version="1">MIPKPLMQAQTETTSHITISPAMSKIRRQNERRQHSIAPPYAVSKQVSHVNEASLKVDDTVGSNTDSTAASNTDSTAASNTDSTTASNIDSTTASNIVPITANMEADTNNIDPYLIKISGLTANLVMPNLIYCKGCKANCDSDLFIDPIKNKIHKQCSNCRFRGYARRHPEIIQAQPFGTQIYTNEASLNAYDTVASNTVFTTDSNIVPITANMEADTNNIDPYLIKISGLTANLVMPNLIYCKGCKCNCDSDLFIDPIKNKIHKQCSNCRFRSYARRHPEIIQAQPVETQIYTNEAVEGSKYDFTDINAIIKGIEIGQTNINEAVISNETVPHETVPHETVPQETVSHETVPHETVPHETVPQETVPHETAPLKTWIDIEPVSIVSQQEIRKASIHRDHTHQIRTEEEFRGELILQLLLWLYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG5</accession>
    <name>A0A0B1PBG5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBG5"/>
    <dbReference type="HOGENOM" id="CLU_000503_0_0_1"/>
    <dbReference type="OMA" id="YPQVIQE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1844"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2023" mass="223806" checksum="20B94228B6DB5F5E" modified="2015-03-04" version="1">MSSPELDIKTLQSLPSQQQDIYLLNFVSILTNYVYQLSPDDCSSQQTNVQKEIFQILNLPSHFLSRVIRNNIGNCFAHILGKGDRKILFESINYLNSIIGNGKNKSEGDLRVKHAAIHCVGDIFASAGDSAIGLHPLVCASLLKVLKYSNNNAGLRAAIFQAFSKIVGKICSSFDEAIARDLWKQARSFASNDKAALVQICACKALKKLSEKTDFFENLHDFENLKSTILKVIDSPSPHVRLAAASCLAQALVKSHTEVPINNNDAPKSKKIKWSNNKKQKEPIDDEEIQRPEIPSQKKTQKLVFTLTEILKHLASFYVKSTTSNNARAGIAICYTRIFQKLARRNVEGMYMKAVVHLTNDILGHANIFNHRYRLLSTRIFIKVILEDVIGSSILGEAGQINAATFLINDVLKNYPQTNKEQTEPSKHTLVTALSALASLINNLGIAASSFADSCRDCLLQVLQHPSYTVQVYTSFCLRIFTLACPQQLIPCLRICLNNLNRELNLIGTGRNPLQRCISYASGLSAVISASSLQPLYGSMDTNSHILSLATRLLKSSSKAEIRISSAQIQVAWMLIGGLMCLGPNFVKIHLPQLLLLWKNALPKPMVKDNISQLSYFESCFLTHVRECALGSILAFLQFNGRLLTIDVSKRITSMLQNTTSFLKSLPPKKFNDDIAQRLIPSLQLYNLEQMTYRRALQCYIKLVNLSPGGKETLLQSNILTLAVSLFADPEDYSPSSLSTSIANSAGNFETIWNVGDNYGYGVTGLVRGFKIRKLDGESENDELEDDWMEEVGIDADISNVLVSPICKSLEHDSLSIFLKELNHYDEIPDPPATELVNVAIELFAIVFPLTPSKIQESILEQLITFSSTSSLQRDPGRKAAINVNIATSLFFTLKVAGKETSSGDVTKLAVEKILQDLLHQFVIHPDQFLRKIGYEGLALLCKSSGSSFTNVEIKYLVDTIVSNREPSARAGCAKALGSIHSHVGNMSTGYYLKTIIGILMSLCNDPYPTVHFWALNSLSRVAESAGYNFSGYVLNSLGMLGQLYVADTHNEEVSSIATSNLELEQPSSVAISRCINSLVNVLGPDLQDVSKPRELILTLVRQLQNEKNPLIHAGSLRCSEHLSLYAPEYIIFPDYVRLLQTDLNSPHLELRNIAIDGLYNLMKKSSVDVVRAAEPGFEDQLWLALDSAPNHEGIKNIIKNWLAQSCLTETSRWLQRCQTVLYMTRPEASETVITSIKDNTNLDLRDEEAAGFASAIGVSKDDTMAPTTGQEPLRWQVRTFAMGCLSDIFLLVSKSNVESSSSAIMSLQKNVSEVIRMAFSASTSNIVKLRVCGLKIIDAVLKFFGKTPDPDFAEVSLLEQFQAQISSALTPAFDADSSPELASEAVNVCAVFIATGIVTDVERMGRILKTLVTALKNFSTGKEMHTIGELKGLSSNAQIMVKMAVFSAWAELQVASTEQKYLVEVLKPYISILTPLWLSSLREFARLRFEPDISMTLGPPSLSGSLDSIYMAFSRETLLRFYQDSWLKLVGAIASLIEQDCDFVFDALDGKPTDIPNTNGYSSGNDINYRDEPVAFFFVLFGIIFEALTARSGSDTLATKEQTLEILQALKKIFHPSVSGHVIYKEVIFSETIDLLDRLVLTEGLDVQMIIVQIGRGLCLAHPFATKPGQTEEEDLSEDIEQLFELTRIIVLVLAGLLPNLTDNPQSVQQRLTDESISLIVTSLSALVDAAEVFPSIIKTDLHACIIHIFATILGTGSCQKTVVPQSLPILKRFINSISIVQEKSVRDSDNSLIQIRSCLKRFLSIYLHAQKRESEVSLYCIRNSLLAIATLFTSGENRLSASEPVVKQFLDEVLECLNDSMTAKAAASCVRLLLLQMPKTPADQSISYYLLPRLIRFVTNSKIKDPENTRSLIMHTLTIFVTTLVGEANLVAISIILPALLARANKEGPTVYKETSARLLDLASIDQNAFRSVVSEVNREQKQFMESVIVAGREIQAQQGSQADDLEYNRPAITLRMDFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBH7</accession>
    <name>A0A0B1PBH7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative endosomal spry domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000327">
        <property type="protein sequence ID" value="KHJ35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBH7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBH7"/>
    <dbReference type="HOGENOM" id="CLU_038401_1_0_1"/>
    <dbReference type="OMA" id="SRSEYQY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="46644" checksum="12050763F118698C" modified="2015-03-04" version="1">MAPIRESHLDAFAPSIVRRNPTPLEKSTSILTDKGKIIFSRSPPIEVVTGVTPPQDIPNRFIFVVFALIGAGFVITAFWFFFRAKNGGFEVITKSHWDNYKKSVVARSVRTGQSLSNATLSTKLGGGSIYHSEKSANSNQNKKKKSRIKNGRGQKIKRKLNTEEGTVLSSDMSQVTRFTEKYRDERRKKLREKNINTDMESIIGELDHSALDDLIAYRHEKPARVGGLNIESEASAFSDSVINGSNTLSTISSLNQNSKVAPKNNKKLHTGGIRKVISVSEGHHSVQNSTVGASMSKKSYIYDEDRIKKEAKRLQEKGRSKQHRDFSFQVGDDNTVISSEGNKSQHERRRSHRNHFSNASESVNENNDLSSNVMYSDVGTKTYHHPIPELTASSVVSNEYYEEKRRKRKESQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBV3</accession>
    <name>A0A0B1PBV3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001022">
        <property type="protein sequence ID" value="KHJ34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBV3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBV3"/>
    <dbReference type="HOGENOM" id="CLU_1058430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="29319" checksum="7164BA802ECDB5A0" modified="2015-03-04" version="1">MEAISLIRRVRIPVFNELVRRASDSSSGSKCGPNPCEKPISSSTFTLPIILGVAVPLIGAAILFLILQHRYARKMREEDANDPHASLDFGLGEVHQVGRSKRAEAMSREKEKASLSSRQVSMDMSINNSYLPSYEKRRSSRESLDSISMPLRKQDPYGPLSQTNNNDTGYIRSHPIYTSGTNDFSNSQPCFYDNLVISSDNSSTFEARNYRPVAFPPRVNSLLPFQSWDASQTIPAPNSRLVEPPQAYIPTKPVAPYANKSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBX0</accession>
    <name>A0A0B1PBX0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBX0"/>
    <dbReference type="HOGENOM" id="CLU_909716_0_0_1"/>
    <dbReference type="OMA" id="HSADITW"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="306" mass="34870" checksum="21D10EBD0CB3CBF8" modified="2015-03-04" version="1">MPENTSASAKISQQFTLFTQLPYELQINIWKVSIPSPQILRIKIEADETLNDKNYFTRNDFDWETEQVSCLKGLKISAPYSKAPGLLGACKDSRATILSVYKGFLKSKGETVIRFDPENDTIFLVPIKLDDMPRCQCHNLGEAFSVDSSPAHTTRKSMLLGLGTPEIPKSFQKHCRDFRPIFGGIQKLVMVWNEFFCIHSADIAWTLSNFPSVKELTLVTPIRKDAYCSAYLQAVGSPIIWCVEQISSHFASASWLVLGLRNDMTTLKRFKQKLQIRKILFDRDNWELPQIVRFGGCYIDWVEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC46</accession>
    <name>A0A0B1PC46_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC46"/>
    <dbReference type="STRING" id="52586.A0A0B1PC46"/>
    <dbReference type="HOGENOM" id="CLU_1240945_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25368" checksum="4C05E451347D486C" modified="2015-03-04" version="1">MSESSSKVRGARILNEIESEACSLEDVLSSLQVRCSSYHNIPGLPLELFRLLQSHSLKGYLAIRSNPTTAAATALINHIIVYQLTNYRGTVVLLDFTGNFTVTQLKNQCGVESLSHLYVFKLLEQSKEVFEEVKQWMLFEEHASHHKVWVGTIMIGAEKIGDWNGKEKVLVSCGRNGWMNVARDEPKAFTEEISVEEAWKISTGKNQNVRWRAWCDEGEYKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD4</accession>
    <name>A0A0B1PCD4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01000565">
        <property type="protein sequence ID" value="KHJ35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD4"/>
    <dbReference type="HOGENOM" id="CLU_017661_2_0_1"/>
    <dbReference type="OMA" id="WNQGLAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="424" mass="47828" checksum="70645864A1C9E575" modified="2015-03-04" version="1">MSSTLQFSKPPQGIFSILPSFDPDVIPPLGLTPFYIPTDIYRNLLDYKVPFTVAAIYAGTVFSLNSYNRKNQSKPWAISKTKLFFTFVVLHNITLALYSGWTFLGMWGTLSRSIPSPHGPDSLVKIVDSLCKIHGPPGLGKSMIYNATSNQWVSQSTPYTLDGTDIAKLQSFGRIWNEGLAFYGWIFYVSKFYEVIDTLIILAKGKQSEILQTYHHTGAMLCMWAGIRFMSPPIWMFVFVNSAIHTLMYTYFTFTTLNIQVPQILKKSLTTAQILQFIVGASYAAIHSFISYSFLFEVPIIKTVLNTSASTTLSSVRSIVTSTSFSEKIKELLIISLGRSNKVQSEVKSPEFTEFHTLHSEKIISDCLDTSGQNFAVWLNVLYLTPLTFLFVNFFVNSYFRRSTKLRGEVQVEATKSLTSKQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCI7</accession>
    <name>A0A0B1PCI7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000177">
        <property type="protein sequence ID" value="KHJ35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCI7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCI7"/>
    <dbReference type="HOGENOM" id="CLU_078274_0_0_1"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27045" checksum="5E55ECC3965D5389" modified="2015-03-04" version="1">MDSTSLPGLSPTEVAFLCEMEVITVVPRQRLESLDLLGGTIPSLRPPQRCDLPLWLALLLKRQKRANILTPPWLIHSSLELILQYETETSPLSFSPPPPHPYPISAQPTATDYISPPFLPSSTADAPSEYLPYHWLELGEILLETCSDDIPDSERVRSLLRDLREVRMTKMRNSIKDLETGGISSLRGIGAMEVAESRAFIVGVVDGLRKLESSREMINREREENEGSNFGEESESDTDMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCQ3</accession>
    <name>A0A0B1PCQ3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCQ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCQ3"/>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="18182" checksum="912F0FD158F486F2" modified="2015-03-04" version="1">MSGPSFSGQTNVTTSENNSMDEQTKLAIRSMQTLMESCPAKTVMSGVMGFALGGVFGLFMASMHYDTPIHTSGTAENAKSLPLRQQLKAGFKDMGSRSLSSAKNFGKVGAIFAGTECCIEGFRAKNDLMNGVLAGCITGGVLAAPAGPQAAAVGCAGFAAFSAAIDAYMRRPSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD64</accession>
    <name>A0A0B1PD64_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000635">
        <property type="protein sequence ID" value="KHJ34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD64"/>
    <dbReference type="STRING" id="52586.A0A0B1PD64"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="44728" checksum="83D1290698868695" modified="2015-03-04" version="1">MTSTDTTTLEVAVENRRIIQPVAPSKRTNPDISQINDNEEMESASQYIPKELAEIIAVRQRRERVWHARLTICTNVISSIDSTLENFKDDISKAESASFKTYLSQAISKFAAYDHSPSPPPIFSHTCPKKSGGPMEHKLPNRPISVVTPFKVTPISSGEILEIDRTRNMPQEKQSTWATVVRKGQKKARVSTTQGPVPPYTTRDNQRSILQKQGRSTNIQQNAIRAGKLASTDSKDKRIFLRVPQKYEWRKLSPAGIREVLIKKLAISPASIGSIKPINSGFALSSSNNDAREVIMKAEHGLFLTGTKLELATNYEPVIIPTVPAYIQTEGSRLEVNKSMLSDEIERVTSVKPSFLKLYGQNNPATPHRTWIAILSKAPRPGFRVFDESGIVRPFKKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD3</accession>
    <name>A0A0B1PDD3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000759">
        <property type="protein sequence ID" value="KHJ34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDD3"/>
    <dbReference type="HOGENOM" id="CLU_046290_1_0_1"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37222" checksum="4916360F4B0F2093" modified="2015-03-04" version="1">MEQTLEIDKIKASRVPTLKLKDSSLHLHQKYDSTAGRPFTRRSTESILSSMGSPVLDSSIALHIQPGPNQDKLQSRFPRNSPVPPPISRTQSMPSYCSMNHSQSSQFHQIISPKGSNSRLRFPRKQVDEVFVGLPSLPSRGRPGTQNLISGEDKSSIFDGNNLSSTKGYNSLPRPRRPDSPRLTPQQIASNKTPPSSNSTSVSISPSSYSSRYNDQYITNTHYCYSGSMSYPGSFSSYSMPSTPTSARSRSSSISSLETIPDSPDAEEAAIEADRIARSKAEIPANCDETKTKLSRDTINSRGRTLGSGFLRDKRKRWSVCGAERRGDLNLDTIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDP1</accession>
    <name>A0A0B1PDP1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000543">
        <property type="protein sequence ID" value="KHJ35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDP1"/>
    <dbReference type="STRING" id="52586.A0A0B1PDP1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="61460" checksum="EC03344F0A7AF40E" modified="2015-03-04" version="1">MDSSPLPPPIPPLTHIPDPFNSSQPPQIPSTPIPLITTVASRQIREPVPPSKRLLPITSQNDNGGEMSSVSKFIPQELVEIVAMRQRRERAWHARILICTSVISNIDSTLANFKDEISKEEAAALQIYLRQAISKFAAHDSSPTPPPIPSKFQQKKQSGIHNIDLPSKPIAVATPITIPLSRASNNGTQPRENQTTQLSWATVTQIGQKKARVINESTTKSAQAKNTNHIDHLNEPKVTNISSRRQPRKGKPISPIKADKRIFLRLPHEHDWWNLSPAGIREVIVKKLAISPASISIIKPVHTGFALSPCNDDAREKILEGQHGLFMTGAKLEPAINWVSVIVPTVPAYIRTLQGKLEVSYTMLADEIERVSLDWPSFLKLYGQNNPAAPHRTWMVFSPKAPRPGFRVFDESGLAMPYKKKKPLEFCKRCNGHHPSKNCSRAPSCGNCGSTMHTEDMCMAATKCRNCGGPHRSDSRRCLARPTRSGTPTKEQLKTYRQAGEREFQAVARAKEAELKAANTKESRSNITDSQNTDSTSSGSKVSIFEDSTVNPMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDT7</accession>
    <name>A0A0B1PDT7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDT7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDT7"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="OMA" id="ICGETKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="557" mass="61042" checksum="8932C0A8F35ACBCB" modified="2015-03-04" version="1">MTDSMDISQESQVPSTEGNQQPPPFPSISNSSPPIASISPPSNHTSSNTTLDSRQLLKPVAPSKRILPEKPQNKSRNTSDGKNAFLPQELAEIIATPQRRERAWHARLMICTTVISYLESTLANFKNEIEKEEVVAFKAYLRQAIANFAAADSSPSPPQVPIHTRPSKGNGKGNDKTSTKNIAVPTPRIALNEAANRGTFKVVALPKIPKVTDNTWAVVARRGQKKARIININNTKTHVSAGNKNAQRAVNKDNSAPVSDKRLFVRLSQEHEWRKLSPAGIREVVVKKLAISPTLIGKIKPVHSGFALSPCSAEARETILKARNGLFLSGAKLEPATNWVSVMIPTVPASIRKQQGDVEISSSILSDEIERVSSVRPTHVKLYGRNKPEAPHRTWMAFFEKAPRSGFRVFDESGVARSFKKKQPLEFCKRCNGHHPAKNCSRAPSCANCGSTNHATEICMAATKCRNCGGPHRSDSRKCLARPTRSGAPTKEQMRIYRQAGDREYQAVLRARAAEEIAATANCNIDLTNSQPSEGDIITDNIQASPVEDSTDDARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE31</accession>
    <name>A0A0B1PE31_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000490">
        <property type="protein sequence ID" value="KHJ35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE31"/>
    <dbReference type="STRING" id="52586.A0A0B1PE31"/>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="151" mass="16203" checksum="B1590DBDDAFB4B9F" modified="2015-03-04" version="1">MSKSKIAVDQVVKLIVGAGQASPGPPVGQALGSKGIKSMDFCKEFNARTANFVTGTPMPVRVTVRPDRSFYFEIRTPITSYLLLKAAGVDLRDGKLKGKTGSQIIGTISLKHVYEIAKIKQSELRLSGLSLEGICRCIIAQAKTVGIDIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEC4</accession>
    <name>A0A0B1PEC4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000302">
        <property type="protein sequence ID" value="KHJ35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEC4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEC4"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="453" mass="49514" checksum="8482475D6780E48E" modified="2015-03-04" version="1">MICTTTLSCIDSALANFKEEIEKEEVAAFKDYLQSAIANFAAVDISPAPPKIPTHSRPGKGSSYGSGKGKNTTNKVAIATPRNMKSVASFEGTSQETTKLPKIPQISENTWATVARNGKKKARVITNTKAQMTPARKTTQTLPNTQKSSTTTLVDKRLFVRLPLDHEWRKLSPAGICEVVVQKLAISPTLFGKIKPVKSGFALSSCSTEAREAMLNAGNRLFLTGAKLEPSANWIPMIIPTVPSTIRKVQGQIEVSNSMLTDEVERVCAIRPAHVKLYGGNKAEAPHKTWMAYFSKAPRAGFRVFDETRIARPFKIQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHTEDLCMASTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMRTFRQIGEREYQAVLRAKAAEESAVFAENNIMDLTSSQDSEVGGDTDNILASPVENSKDGALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEG8</accession>
    <name>A0A0B1PEG8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEG8"/>
    <dbReference type="HOGENOM" id="CLU_2160280_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="12338" checksum="6850EA37B7BAF10B" modified="2015-03-04" version="1">MESIVSTTGPRVTKTSLPPKTQHPEKSQGNKSSWVTIARKAAKLSDPPVASISWKYTQQTNNSHQDTRKEDKRLFLRLGEGHEWRKLSPVTVRIIVADQAGVVISAIASIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEK0</accession>
    <name>A0A0B1PEK0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEK0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEK0"/>
    <dbReference type="HOGENOM" id="CLU_009629_1_0_1"/>
    <dbReference type="OMA" id="EHNQAVQ"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="543" mass="59858" checksum="4A1CE3F6E0B5A03B" modified="2015-03-04" version="1">MYTSTRQCHNLPTPIRCSTSDYSNVAIIGGGISGLTTAYYLIRQFPTSKITLYESTNRLGGWLESESLDIGCGQVLFESGPRTLRFGTTSSLVTAELIQDLGLEEQIIISAKDSIAAMNKYLYYPDHLVRMPTPEENILWRINRILTEPAFKGIFTALLEFRRPPRSADLDDESVASFFTRRLGGDNLVNNIHSAILHGIYAGDINQLSIKSLFPTLWYMEKHFGSLLRGVFICAKDKLKLISPSESSIRKEIAPKIAAALHQKLDKAAVFSFKKGLGVLSNALEDALLKKPNFSLKTGDQIKSIQLADDGIEINSARNNSPAKFSHVVSTLLPNQVSSLTSKLPSLSLIPSVTVMVVNLYYSSMDILAAHGFGYLIPRNVPYEQNPECALGVVFDSDAVQGQDTVFGTKLTVMLGGHWWDSFESYPDAEEGTMMAKAVLKRHLGIVIEPDLVRVKLQRDCIPQYTVGHQSILAQAKEEMGAFMGRLSVTGCGYRGVGVNDCTAAARDLVSRMSSGIRSKMITGLEWIDEDLQQIKIRDSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEM3</accession>
    <name>A0A0B1PEM3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000430">
        <property type="protein sequence ID" value="KHJ35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEM3"/>
    <dbReference type="HOGENOM" id="CLU_2401314_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="93" mass="10446" checksum="7ED0B58B50110841" modified="2015-03-04" version="1">MLRPAKSKSSPSYGAGVNAQYALYVWDSQEDSHNPSLQDLPFITAGLNRLRFYITFPYPTGRQPLRPANKVKSNSSTSQTMAITDKRPFVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEP2</accession>
    <name>A0A0B1PEP2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000264">
        <property type="protein sequence ID" value="KHJ35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEP2"/>
    <dbReference type="STRING" id="52586.A0A0B1PEP2"/>
    <dbReference type="HOGENOM" id="CLU_1696811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="155" mass="17861" checksum="D3C261A0D8975F0F" modified="2015-03-04" version="1">MPEKINYSVRTLDFSRSGRFDGLIPASRWLAFDMRNGNNIASQEEFLEAVETLLDGDAVMWLNSSKKFREMIDRRYDATLNDIEMFKEALVAEFPIHVIERTEGNVQLEIRIFKETPEESLLKYYGRAKNLLRKACGRNEPAQTASGLGVNSYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEU5</accession>
    <name>A0A0B1PEU5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2199</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000389">
        <property type="protein sequence ID" value="KHJ35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEU5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEU5"/>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OMA" id="KMINYRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="190" mass="19361" checksum="7A86D6E429CBBE51" modified="2015-03-04" version="1">MANKQGKMAGLVLWRLRVTLQDGRQLVGQMLAFDKHMNLVLADTEEFRRVKRRATKGASAPGASNTSTSIVESEEKRALGLIILRGAHVISLSVESPPPADPTARLGVKTTSGTVPALAAGTGVARTIGRGVPVGLAGPAATAAPTGYGAPGFPGAPGFGRGGPPPFGGFPPPGFSAQAPPPPGFLPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEV0</accession>
    <name>A0A0B1PEV0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ring-14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000494">
        <property type="protein sequence ID" value="KHJ35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEV0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEV0"/>
    <dbReference type="HOGENOM" id="CLU_017137_2_1_1"/>
    <dbReference type="OMA" id="HPCIKIT"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="437" mass="50831" checksum="4D7062502C4109F4" modified="2015-03-04" version="1">MKFAHEFRSVLENEDFPDRWVASAVAYCQLKKCLKKMQSELQISGSNLSDLKQKFTSDENEFPKSWDLSLIDHQKNNNIKSQTCVAKLSLLILFQNGITKDLALSPITTEYCQELVPENCYLNNSLKRSWSTDGEFPQQMETSLIFNVEFFNILKEDVASLDLLHLQEQKALGRRIEALSIAIATLTKPSKFRRTDMYRWRQLFELYLEAGIFFSRHELDCGTHDSRTAAKQLRWFQNQLSRQELENLFKIPASKKALDHFISINLSLLQILKFQEINQKAVSKILKKFAKRTKLNVGNLFSRLIKSDILQPGSIAKAIYSKVTQDLIQIVPQINDYLCPICLAIVWQPIRMKCRHFFCVQCAVTLQQKKIRLCPLCRENVVMEADQDNIDESLVIFLKKYFPKEVKLKQIADETVNGIERYGIYYRHPSEEKCSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF35</accession>
    <name>A0A0B1PF35_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thioredoxin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000203">
        <property type="protein sequence ID" value="KHJ35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF35"/>
    <dbReference type="STRING" id="52586.A0A0B1PF35"/>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OMA" id="TAKDWVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="129"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="37363" checksum="6C665FB4C6DD9EF6" modified="2015-03-04" version="1">MLISSPEEFQSILHTSQILVAYFYADWCELCKRIAPVYDELSLVLSIRNQVTFVKVNIETHIEIASEYAIASSSVPTIIVLKYTEQIERISGVDIEEVKTVVGRITSESESLVIPNKPGVSSSIRSSWPIANIPRGFNDITEEVDLKGLDLLNANNEFGSAQVLFDNQKPSGLKDDINSSVDIKDWVQSDTDEQLMLYIPFRSVLKIHSLQVTSAPPKSSLDQRQVEVTMRPKIIQIFSNRANILGFEEAEQIMATQTITLNESDWDDRGTATLILRMVKFQNVSSLVLYIVDGVIDEQSSNSSCRTRLDRIRIIGDSGEKRDQGVLERYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFR3</accession>
    <name>A0A0B1PFR3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nucleoporin nup49 nsp49 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFR3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFR3"/>
    <dbReference type="HOGENOM" id="CLU_027081_1_0_1"/>
    <dbReference type="OMA" id="KLPTHYH"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="402" mass="42599" checksum="8D8EE86AA1D7F9C1" modified="2015-03-04" version="1">MFGSTISQPANTGGLFGAATATTTAPQNGGLFGSNSSTQVPTQVGGFGSSKSLPGNVFGQSVSVSSQAQSSGPNPTATLNPPTTASFGSVAPALTTGSFTTPGQQSTATSGGLFGQANQNQGTFGTFGSQNNPLQPQQPTTSTGLFGNSSINGSSNNQSLNQQSQTIPGVLIDASNVRGTTRYNDLKDELQKQLLEVDTMIEAQIQLKNQCDAIMPAHEVQLSQIPDDVEFCRRKRIGVDNTADADIHAISEVQKLIKRDAEAAKLSFAAIDMLRLPPQYHIPGVLSQKTNKSDDSGYENIVEFFSQTADELSAKLTIFKKYLGEIEQHLRGVEVNSAHQINVLVAKKKGNLPAEESSFDQLACVLRDFETGLLTVAGKVGETRKGVTTLQLNQFRPTINNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFS7</accession>
    <name>A0A0B1PFS7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000292">
        <property type="protein sequence ID" value="KHJ35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFS7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFS7"/>
    <dbReference type="HOGENOM" id="CLU_102600_1_0_1"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="17559" checksum="69FF2DB589B89D0C" modified="2015-03-04" version="1">MADDAQHDGHFDSADAGASATYPMQCSALRKNGFVVIKNRPCKIAEMSTSKTGKHGHAKVHLVGIDIFTGKKLEELCPSTHNMDVPNVTRKEYQMLDISDDGFLSLMDDDGETKDDVKVPEGEVGDKIKKLFTVEEKEISVIVLTAMGEQVAMDAKETSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG57</accession>
    <name>A0A0B1PG57_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000345">
        <property type="protein sequence ID" value="KHJ35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG57"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="39776" checksum="FA604A5C945EA4DF" modified="2015-03-04" version="1">MAPPALTKRALPPDPPDVGNRVSKSTSTLNRSNSIAISIAHSTLHTKAALQKSSILEKKLGVVQFSIDEQDEQDDEDLEMDAVTGKPSTNTINTDPLEDFPPLTGVSELNAVKITQNEDNVNETKKKKNATSLMDAIKSLLDLTNPFLKKLEEDHPRVGADFLALLADGASRAMRGATPPHGQSKEDRRVIIRLSPDHETRKISSFELRQKIQLLIPNKTLIADVWTVPSGVAILAPTPAKAAALLQFKEVIENRFGDACVERQETWTTFVVGPIPKKIRSLDGVHDPLDGLLHEELASIRDVVPIRHVSWTRRSLNDEPLGNIRICVPEINANKFPSRLRLTVEFKLMMDRVQELRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGB2</accession>
    <name>A0A0B1PGB2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cullin-associated nedd8-dissociated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000207">
        <property type="protein sequence ID" value="KHJ35916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PGB2"/>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1344" mass="147444" checksum="331DD826B83DB535" modified="2015-03-04" version="1">MSSTQIPLHPTSQTVAQLLPKLHDVDPDYRFMSLNDIFQVLTIGKQDLLHNDFNTAARAVDGIVKTLDDQNGEVQSLAIKCLTPLVNKIPSSILAPLIEKLSTLTAKNSIDNSITAMALRTVIVALPRPVSGVHPTKEVVEAYSTISRVLIPRLVGQLVDTKAKYPNLSHIITSSGALHIETNSDVNPETVNVLIEVVRCFGPLLQKSEITALKSVLFSIVDTDRASSSAKKRAVIALSILGIYLTDEGLCDFVTQLAQRLRNPPTLHRRKIFVSILGHLARSIPSRFGIYVKTLAPFVLSVLNEQDFTEQSDNSAEDEENDHEKNDVLEAALIALDGFLSSCANEMLVFTEDVMSALFRFIKYDPNYNDDSDDLMSDAQSDCNDNEFSDDDDFEADTDFDDDDDDSSWKVRRCAAKALYTLISTRGSGDLLEDGTLFAKIAPVLIQRFAEREESVRLEIISTIASLIRKIGEISYVNLSSDDFSSYTGSISYSRKRRRESSSKDFEPKDILSLSAGLVSPVADTIPATGPRAELAKLSPIITKASIKLLRSSSIPTKQAIVNLLDDVVSAHHGGLSEYFGQLVHPIIDAIKPTSTTSNTLGTASATANTLRIAALELIGDIISTHSSSILHSHLDLIIPAVIVAINDKYYKISSKAVETIEQLVKALTPPRSKAVNQRTKSDIEKLYKTIISRVSANDADLEVRQRAIQTLGIMIARTGSQDSLTLLSNNDHILALNLLCDRLKNETTRLAAVHAIDTIALLRNTKNQLQPEWIREVSLELSAQFRKADRSLRGASLGALKNLLVTSSVSSLLDSVTIKNLVAALLPLLTSIDLHLLAPALYVLASLVENDSSLVVSDRLNSALCELLKVNLGSSVIEALLQLIKNIGSHGAGQGLMSGLLNYVNVNGDPAVVGKVIGTLLVYGGPSVGVSIKDFLEEVNNANSGDIRRCLALAVLGEAGLCLGDKAKLSPSTFIAQFSTESDKVRLASAVALGRAGAGNIQHFLPEIIKAMSCEGNAQYLLLHSIKEIIQQASNNRASIMEYIQLIWNQLISLSQIDENKGVGAECIGRLVIISPKMYLPEIQSYLSDPKPSVRAMAIQAIRYTLVDGDTPFEKIISKSIVDILSAMLRDNDIENRRLALATLNSAAHNKPGLVIPNLTELLPFVMHESVVKPELIREVPMGPFKHKIDDGLEVRKSAYETLYSLMDIAFSRLSILTFYDRILAGLRDQHEIRALCNLILTKLLVLDPEETARRLDSIADAFRSILSVKLKDNAVKQEIEKQEEAVKGVLRVTLLLHETIPRASAALGTIHDNQGWRTYWEWVEKDFDSYLRNLKEEIRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGD8</accession>
    <name>A0A0B1PGD8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bax inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000315">
        <property type="protein sequence ID" value="KHJ35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGD8"/>
    <dbReference type="STRING" id="52586.A0A0B1PGD8"/>
    <dbReference type="HOGENOM" id="CLU_046868_1_0_1"/>
    <dbReference type="OMA" id="TLMWSER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="39156" checksum="652D23ED05AD4A08" modified="2015-03-04" version="1">MTQPILLLRHSTRQLSQNAANLLLGPRITLSSFSMQGLSKAGSTGAARRVHNKTARTWSWIFTSQRMGLQTWPFKTQNGLGRAWKSHYHSAGTVDNSGSLMQKLVVGGAMFGGTLIAINLVFNRETREDGSMPAYERSYLNDTFLHTGLGIGIIGLSARAMFQSGAMYRMMATSPWIVMIGGLGLSMGTMMATRATDPTNYVAKYGFWAAFNGTQGALLAPLLFLAPPALIARAGLYTMAIMGSISFVGATAKQEKYLYLGGPLLAGAALVAVSGLAPMVLPATAVRTLAISENLWLYGGLAVFGGFTLYDVQKVLMHARMAQQGLLRRDAVNESISLELDFLNIFVRVVQILMMQQSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH66</accession>
    <name>A0A0B1PH66_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000229">
        <property type="protein sequence ID" value="KHJ35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH66"/>
    <dbReference type="HOGENOM" id="CLU_577711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="473" mass="53147" checksum="73FCEB22833B75F2" modified="2015-03-04" version="1">MSFSTLNFGVNITESDHDLETPFQVIDLTGPDESIDYITPLDNNVILEDAIGFEVEKSSYDIRAQVFKSQASSDESRTHKSGKKKKKRKKNATLRRAIQKLYDQERQQELNIERCQALSKKTNQESKTTKTHNVRSTEASKHEELEIEMRQPQVSEGNKSLASSNMTGPTLSTMEKEEFTVPQNSEIMAEKEIEILPSLNREQIPAKYKDEIKSMVINSAITNNYCLSMDEGKSLNSCIMADDETFVEIKEKDIGGNLLLSVKEAESLSVNVEKQKEQSSIEGCHIQQALKAKEIGLNDKKYRKKQKKKILSGCNNKYCLTGSLAKKDGNFNQPKNITIIDLSSPVLTKNVLTMPNCKSNIITKKKNPAKSKNKVVSNASALVTTMPKTKEAKRSKRALKKARKRNQAASVNSNNINIGTSKINDLNSEHRKEKLEQGVPGSNLKKIPDYLEPYKTDTEKEVLSLMRELLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHB5</accession>
    <name>A0A0B1PHB5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01000105">
        <property type="protein sequence ID" value="KHJ36221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHB5"/>
    <dbReference type="STRING" id="52586.A0A0B1PHB5"/>
    <dbReference type="HOGENOM" id="CLU_018152_0_0_1"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="592" mass="68333" checksum="6200F25875F0BB24" modified="2015-03-04" version="1">MSKYEKTPRQNYLARRSPIIHIGPFIIFLTFNILAALFIPIHDCDETFNYWEPTHYLSHGYGLQTWEYSPKFAIRSWLYIALHAVIGSFRKLLPYTKVAEFYFIRYVLAICCSLCQTVMFLVIKNTLNIRVALIFLISTVISPGMYHASVSFLPSSFSMYTTILGISAFMDLKKNQSERIFYGILWFSIGGIIGWPFSLALSVPFLLEEIILSCKKGMNAFMVLIWQSKQAILASLIILLFEILISGIFYRRLVIVPLNIILYNVLSGPGPNLYGTENWHFYFRNLFLNFNICFLLAIISLPLYIIQKSPSRKTWSTANNVRGITLLIPFYLWLVIFSLQPHKEERFMYPVYPCLILNAAISLHLLLTSFGHLDSKKSLWKLPGWLKLLTVISILLASVIVGLARVYGIWTAYSAPLYIYEPLSNEGLNNDVVCFGKEWYRFPSSYHLPKNMHAKFIKSEFRGLLPGDFSETETVNGFRSGTWMETSGMNDQNLEDVGKYIQPSACDFLVDTYYHSVSAPSPLEPNYTLDSSNWEPIYCVPFLDASRTSIFGRVIWIPEIQKFPIPRWKLAWDSKVSRKWGRHCLLKRINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHS9</accession>
    <name>A0A0B1PHS9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000062">
        <property type="protein sequence ID" value="KHJ36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHS9"/>
    <dbReference type="STRING" id="52586.A0A0B1PHS9"/>
    <dbReference type="HOGENOM" id="CLU_028356_0_0_1"/>
    <dbReference type="OMA" id="THVWRAN"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="45"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="501" mass="55915" checksum="ED818674D97A3A41" modified="2015-03-04" version="1">MSTSSRTSQRHIASTPSNSRQARSATRGDISLDKLVSHLLAAKLSLASIKTVSRANEIVISARAALEECAVVTARTNFLRKGIKNQAATLRQLRAGIVAVYDQGQKDFMNVIRTLDAANQRLENTMNTLRSTIVEAAFRPEVEEPRCLLDFVHEQGVETMRDSLKENIREAKATQAEFDSAIVSLDNDLSALKASMVTKSDALPFSEFESQIPDSLQCLESHAQQMADLLESLVQHFDLCVTAIRNTEGGTAAVRKAASSPPPGVDAVSVSGVISSGSIPANEEQISDEEMQEIHDVLEKDARQVEGVVMELQDLLTDMEVKYQVILDFVSLLNASYQEQTATFKMLEIVGSRLQGYVLASHDFNLRWDETKASILSQLSELESIRIFYENYYSSYDALILEVQRRKQCQDQVQSVLKKAMDQLDRLYEFDSREREEFSADVGEFLPVDLWPGIGDVTPRWGFVRVDGGVTDSIPHLSNEIIERASMRARKRETINKTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI29</accession>
    <name>A0A0B1PI29_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000124">
        <property type="protein sequence ID" value="KHJ36159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI29"/>
    <dbReference type="HOGENOM" id="CLU_076390_0_0_1"/>
    <dbReference type="OMA" id="RTKEANV"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23093" checksum="5216CB88215001AC" modified="2015-03-04" version="1">MASENSKSANQVDSTPKKRRPGFKIGPDNLPDGTYRRKVVKIKKELIRKAKIKKSYAKIKASESISLATTNTLTSSLKNLPSQELHPERQAMLNTPDEEITSTNKQEQFPQRRHRSKRPSYFEKEQAFAEKKKAEKEAQREEFKRRAKERAEKLEDRKRFRKAMAKARIPGKNGQRKLGRESVVLLEKIKKNFEGKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVJ0</accession>
    <name>A0A0B1NVJ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004436">
        <property type="protein sequence ID" value="KHJ30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVJ0"/>
    <dbReference type="HOGENOM" id="CLU_2039805_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="121" mass="13465" checksum="CB87BA1AAE0F668E" modified="2015-03-04" version="1">MAPIFFKPVSQSLEKKPPLNDKLPLTPPKNIKYPTLSPFSPSTSPCLPGTLIQDKDKDVDEELDFNNDDDEISPLRLALKKALAVNGTMQSRIFQLELFSKQADNFAADIPILKNESVPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW21</accession>
    <name>A0A0B1NW21_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nadh-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004899">
        <property type="protein sequence ID" value="KHJ30168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW21"/>
    <dbReference type="STRING" id="52586.A0A0B1NW21"/>
    <dbReference type="HOGENOM" id="CLU_083053_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21112" checksum="FA44E56B29AB57B7" modified="2015-03-04" version="1">MLSAARGRFFLSLNHEIQVQARRAYAFGASERRRSNEPINYNSQNIAVNPNDNRLSFNAPHQNTQIDQAVTSNTEKLLVPQAPNRVGVWSKSQNPRSKAMSGPRFEQTLIEIQPAPLAAIELSHKQVVNWSYERSVSCDGGGGPLGHPRVFINIDKPQICVCGYCGRPFASEHHRKHIESLLNTPFPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWJ7</accession>
    <name>A0A0B1NWJ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcription factor spt8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003684">
        <property type="protein sequence ID" value="KHJ30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWJ7"/>
    <dbReference type="STRING" id="52586.A0A0B1NWJ7"/>
    <dbReference type="HOGENOM" id="CLU_010934_1_0_1"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="109"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="396"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="629" mass="69107" checksum="E96C9E416D344556" modified="2015-03-04" version="1">MGSTLGDDDWASNASSEDELMEDVDPIEPDGDLEAEEDDEDDDEIVEDDDVEGDEDVIDQPLSHISKCNQNGHKNATNSEPQVLTAQNNTKSLKQLFYPRPEAITASSYDIVPTIAAPQGTSINAITATPDMRYWFSGGTDCYIRKYDGVATINGKALLTVAQRHPFVDSVVKAGVLLSYWDNEEPLTKSAGEDPSLSPVYSLAVHSEALWLLSGLESGSINLYSVRHDEGKRIAYMNQHKSAVSVLKLAKDEKSVLSGSWDKEILDWDLNTGQVKRSFEGSGGQISAIEVRPDSNVAISAEPSNLMPSNEEFSGYDSKQNFSNEKSFNNHDGDLNEDAHESQTDSLFGGSDTNSLFLEAAGDNPPSAGLFREEDNSNTEIAIDYTDVDVKFEAQEISSKDKEDFSTFGITKPVTEELKSPSEGQANRTKDHQMGIEDVKSPKTMSPNFQDSFITSDSTFLAASIDGTIRIWDRRQPHPVAFIPTRFGVPPWCMSACWSPDGNFLYAGRRNCTVEEFSIHHGLKNVERTLKFPFGSGAVSALRAMPNGRHLLCASNDILRLYDLKESQNVKRSTVPFLIVPGPPRAGVIAALHFDPTYKYMISIAGNRGWEGSTTEVLIGYEIGIPVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX70</accession>
    <name>A0A0B1NX70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003385">
        <property type="protein sequence ID" value="KHJ30977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX70"/>
    <dbReference type="HOGENOM" id="CLU_883383_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="35793" checksum="763032741F2C82A1" modified="2015-03-04" version="1">MPLLKAAEAIRSCGISEFRWDSNDQEDVHTFQGEARRICRSYPESILRALVSYRPEVMSSTSWSYESAPITMEQVKDPEKANAAKRVAEITRKYRARAREYEQRIQFLKTDQGGIRRGRLVKHKEKKIVYLTAARTIMSCAHFDKGPTLNHEITAQRLLERINEKIRSKGDTPRVTEHLTLIVNGEINEKRLREANGRGSVFGWHPDEYARGIDAALSWVIDDCAHESRLVYYVPRYIQVKTKVRTHRLQQDVATSDFHRRVHLAAEGSHATNLDAVDLAPSFATKSAAPIPGIRAVSEVVEDSQGSKIKKLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYE2</accession>
    <name>A0A0B1NYE2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01005441">
        <property type="protein sequence ID" value="KHJ30055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYE2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYE2"/>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="OMA" id="WLGTMFM"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="35579" checksum="1385882149BD2447" modified="2015-03-04" version="1">MSYSITTAPEIVGAISLSPWANFDKVWTAIMGYPASEFQFVRGKTPFSTLGEAVSMVLVYMILVMGGRQVMRDQPAFKFNTLFKIHNFVLTLVSGCLLVLFIEQLIPSLWKHGLFRNICSSPGWSQPLVTLYYINYLIKFYELLDTIFLVLKKKPLTFLHCYHHPATAVLCWTQLAGSTPISWLPITLNLFVHVVMYWYYFQSARGVRVVWKKWITRFQIAQFIIDLGFVYYGTYSYIVDMRWPHLPHLGTCDGAPWAAVTGDLILLSYLILFISFYLATYRKQTSRKAAAIGIERKFDTINTPAKTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYG0</accession>
    <name>A0A0B1NYG0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ras-like protein ced-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003352">
        <property type="protein sequence ID" value="KHJ31013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYG0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYG0"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OMA" id="RRMAPIT"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="22046" checksum="64AF3DDAA3039136" modified="2015-03-04" version="1">MAAPGTQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVRAKWFPEIDHHAPSVPIILVGTKLDLREDQATLESLKQKRMDPVTYDQALIVAKEIRAHKYLECSALTQRNLKSVFDEAIRAVLTPKPQVVKKKANKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYK8</accession>
    <name>A0A0B1NYK8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative woronin body major protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-5A family. Hex1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002867">
        <property type="protein sequence ID" value="KHJ31472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYK8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYK8"/>
    <dbReference type="HOGENOM" id="CLU_021655_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140266">
        <property type="term" value="C:Woronin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04469">
        <property type="entry name" value="S1_Hex1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000033">
        <property type="entry name" value="Woronin body major protein HEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037318">
        <property type="entry name" value="Hex1_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="4">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="40750" checksum="A87647AEC2C12153" modified="2015-03-04" version="1">MWLAADNQSAVQQNNIVTTLPPQHNFQQNEVPIKHEKPELTLSECKEETFVSEEQRPFKFSKPEVDVQPPTFTHHADEFSSEVPRRRRTYRQYHESEIDVAEREYRTRYNSAPRENYFVSKNTEEQPHRTYPDLQEEIPAVTSTINLNKDNYQEDYQPPSFSVNPPKPVLSKKSKTSSCQEKLNQSTPTKMGFYDDSGRKECGRPAAEPAYTHNTVTIPCHHIRVGDLLILQGRPCQVIRITTSSATGQHRYLGVDLFTKQLHEESSFISNPSPSVVVQTMLGPVFKQYRVLDLHGGSVVAMTETGDVKQSIPILDQSGLLKRLTEAFETGRGSVRVLVISDGGRELAVDMKIIHGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ03</accession>
    <name>A0A0B1NZ03_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nadh-ubiquinone oxidoreductase kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004642">
        <property type="protein sequence ID" value="KHJ30255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ03"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ03"/>
    <dbReference type="HOGENOM" id="CLU_095735_0_1_1"/>
    <dbReference type="OMA" id="RTECEMR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15883" checksum="87BCE3113D8F4927" modified="2015-03-04" version="1">MNSIKQSPASLKQFYITLAIIPLSIGLFTASRPDADGKLPVITRFIDSFSHYKEKWSERNTLHTKAVEQAGFDRNLFNSSTRKRRVVDLKFPEIFNTGSPFNVVAGQGPRNMDELVAHYTKQNADEEERKLALLRNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZA8</accession>
    <name>A0A0B1NZA8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative dshct domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004408">
        <property type="protein sequence ID" value="KHJ30355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZA8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZA8"/>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="323"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="594"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1272" mass="144791" checksum="EC31EB2E2E187592" modified="2015-03-04" version="1">MVDRLAKVLEDVHISSITRPDDWVDNILEKERPREHLEQSPEDIKHELEHKYLTPKSSFSKELLQELQLRWETSTDYNSLFQIAPTQSRTITRFIREGLEGRVIGYKEVTVNANSITAKNSTSLLRKPGRKDEFVRGAAGFFPFAPGGLEGVEAVAALEDQAFINTSTTKNHTENKLERVIKLSSEGSLLTIPPGFKRGGDFSLNSSKDANDEKDSVELTILLEQEPSENLGEYNRQDEHNNSANFEEEEDTNIEDDIDALLPIEYPALEPHGVLAASSAKKGAKQWAHMVDIKKGFHNFRELVPELAKEWPFELDSFQKEAIYRLECGDSVFVAAHTSAGKTVVAEYAIALATKHMTKAIYTSPIKALSNQKFRDFREVFDEIGILTGDVQIAPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPEHVTLILLSATVPNTYEFASWVGRTKKKNIYVISTPKRPVPLEHYLWAGNEMVKIVDSDKRFIDKGWKEANDALSGKDKKQNVLLQQDFMRGGRNNRGVRGAGQIRGTIQQRGRGVPSRAAHTYGHMGHTGRPGGRTSAAQDKNLWVHLIQFLRKRSLLPACIFVFSKKRCEENADALSNQDFSTATEKSAIHMTIEKSIARLKPEDRILPQIIRLRDMLTRGIAVHHGGLLPIVKEIVEILFAQTLVKVLFATETFAMGLNLPTRTVVFSGYRKHDGHKFRNLLPDEYTQMAGRAGRRGLDTVGSVIIVTLGDFEAPPINDLRHMILGEPSKLRSQFRLTYNMILNLLRVEALKIEEMIKRSFSEHATQQLLPEHEKAVKISEEDLNKIKRDSCEICDTDLDACHEAVQTYRSITAEFYHRLLLTPIGRRMFAPKKLIVYLKEGIRTPGILLKEGSSGGAAPTVHVLEIRTNRDARDSTDLLPYMPKYRKLFTKLPQNIKWFHVKTLQISVSSIECLTKTTLNGVIPEIFGTAEEYYRAKDQLFKICQNWESTDWDEVDWLKIKDVYLRELLNKREELSEIAQKSKALTCPQFISHFAMCNDQWLIKENISQLRKLMSDQNLQLLPDYEQRIQVLKDLDFIDESSRVQLKGKLACEIHSADELVLTELILDNILAAYEPAETVALLSAFVFQEKTNVIPNLSVNLERGMKTIIRISEKVNERQTYHQVILSSDDSNDFLARSRFGLMEVVYEWARGMSFKNITNLTDVLEGTIVRVITRLDETCREVKNAARIIGDPELYTKMQTCQEMIKRDITAVASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG2</accession>
    <name>A0A0B1NZG2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 40s ribosomal protein s28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005310">
        <property type="protein sequence ID" value="KHJ30071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZG2"/>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="67" mass="7651" checksum="5A84094F65DD569A" modified="2015-03-04" version="1">MDSKVPVKLVKVIRVLGRTGSRGGVTQVRVEFMDDTTRSIIRNVKGPVREDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN6</accession>
    <name>A0A0B1NZN6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0401</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002884">
        <property type="protein sequence ID" value="KHJ31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZN6"/>
    <dbReference type="HOGENOM" id="CLU_013253_0_0_1"/>
    <dbReference type="OMA" id="NGVGEYE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079594" evidence="12">
        <location>
            <begin position="22"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="135"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="447" mass="46710" checksum="CC137ED7D81D9E3B" modified="2015-03-04" version="1">MRSKMHFQALFLLALAGLLSAAPSSSPIQKRSFIVKRVPNPGYMGRTPGAGTRALIKAHRKFQFDLPQGLLESMMANGAGANTVPQTAGKAAGNFSQASTTNTGLARQSGVAEKAPQSSGTGKVTATPLNGDVEYLSPISIGGQMINMDFDSGSSDLWVFSTQLPAASIGNHTTYDSKKSQTFQPMPGATFKIAYGDGSGASGNVGTDTVDIGGATVTKMTVELATAVSQSFTADTGSNGLVGLALSKLNTVKPTQQKTFFESAMPSLNMPVFTADLRNNAVGAYEFGNIDSSKFNGTMSWAPIDPSNGFWQFSTQKFQVGNGQTVDAPGGTAIADTGTTLMLTSPQIVNAYYSQVQGAKNDAQAGGITFPCNAQLPDLKVDVGGNYMATVRGSDINFAPVDQAKTTCFGGVQAIQSNLQIYGDIMFKSQFVAFNLGNNSLGMAPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZQ0</accession>
    <name>A0A0B1NZQ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative dna repair protein rad18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6130</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004076">
        <property type="protein sequence ID" value="KHJ30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZQ0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZQ0"/>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="354"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="737"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ30520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1162" mass="132172" checksum="1DCEF58C1B18757B" modified="2015-03-04" version="1">MVPRKRQSNNDEDEETSPELSENQENGGRKRKHQRLSNKQQQQDSLVSDEESEHEASGEKQSAQKFCSQYESIRDDGFKHLANPELDDHKAAQAFLKRRDRIGDNHAANNAIILEITCINFMCHSRLHVKLGPLINFVVGMNGSGKSAVLTAITLCLGGKASNTNRGSNLKSLIKGNQEKAILVVKIKNEGNDAYYPEIYGPSIIVERHFSRSGGSQFKLKSSRGIIVSTKKADVEDIVEFYQLQVDNPMNILTQDKAKSFLHQSTPAEKYKFFAEGVQLEALNNDYSLIFDTCDAIEAKLEESKDDIAELEREASVAREKAEAARQHDGMRKTASILSKKYAWAQVVDQENILAEKERAVLEIQQRIEDDERLVANHDRSFQKAEELLNRSKESLQILTDEAGPIREAEETARSAYEAASLDVKKAIAEKAKIKAELAEAKEDIRKRVKEIEAEQKLIAEANGGSHARKQAEIDRADEKLKETISSHRKSVEGLPLIDQKYDEAKINLNRVETLSEAKKVEIQKVRSLLHELNSGRRDPMAGYDVKMPRLLNQIRQDREFKNTPVGPLGLHIKLKDATWGDILETQLGVQLNGFIVTNTSDQRRMSNYLKSYNMANFCPVMIMGENQIIDTTENEPDPQYLTVLRVLDIDNELVRQHLIINQAIEQTLLIKHREDALKVLFDGTRPKNTRQAYSLHDNQRRHGIYFGFTGRGSSFTSGIKPPRGQPRMQTDTESKISFYKETLRLLEHELKICERDIFDARSSVQSCLKEVSQRRIEIERLKVATQRAETLLENLRAQLEDLNPEDGRLDVLKKCLEDEEDKVRLYGESYGNQALELERLQQNALELCQNHKTHLVSMKDHEAKTNKLEGKIRNTDQARHTALREKNSAIVVLERRQHEKSVLKRKRDAAVTRVAEFMEGASKVCPRVPLEPGETTESLEKQLDRIKQILSAHRKRQGASDQEIFDVATKKQELYIQAKESRSGLEKLLRLLKQACLIRIQMFRRFQASISARSRINFQYLLSERDFRGSLNIDHKRKKLDVHVEPDKAVVTGKGRQTKTLSGGEKSFSSICLLLALWEAMGAPLRCLDEFDVFMDDVNRDVSTKMIISAARKAVGRQFILITPKALGAGVANGDQDVRIIKLLDPREKGQQRIDEMIESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS8</accession>
    <name>A0A0B1NZS8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative adenosine rna-specific isoform adar-a variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002857">
        <property type="protein sequence ID" value="KHJ31488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS8"/>
    <dbReference type="HOGENOM" id="CLU_1004689_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="29936" checksum="48B0816EE51BD56F" modified="2015-03-04" version="1">MIPYNSRHKPSTNSVSGQSLLDIQDIELWEPEYQSESLPLATRPNPSHKKRLSEIMDYEQIFASEKRALQEIGNINWVGKLNEFRMSRIRGHERTEAEFKINHDYSHKSPRFSCSVKIPESPSILGDTQDPTTFSAKKPAKQYAAKKAIDWLIKFNFMAADGSAHFSSLSKESIASKVPDLCRRLGLNTPRYVIEPIVPSSPMYSGYADFGGDPRIKGFIGQVTGFYGKKNAKDHVAREVVTFLTQLLEERNERILSTRKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV5</accession>
    <name>A0A0B1NZV5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative candidate secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005089">
        <property type="protein sequence ID" value="KHJ30114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV5"/>
    <dbReference type="SMR" id="A0A0B1NZV5"/>
    <dbReference type="HOGENOM" id="CLU_029060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079597" evidence="3">
        <location>
            <begin position="20"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="56557" checksum="FC4DD4E6FD5BD924" modified="2015-03-04" version="1">MQLSYFLLVFIFGIYWVASSPGDTNQRGYECGDIFFSDYDVKEAVSRCIELGLEDHEFPHLYLGSLYDSTDASNYLAWPIAKGYIFNISTRHNRSTFYVILLRESKKVIGIVSRITNNRYTRCIKRGSPITESPTSISGETNGFQCADKYFSDQMISEYVRDAHKELQGKGKRISYLNAYAGTLYPKDSGYLIWPMISNKLFHNYSPDRAGPFYVLIDKNGKFVDTVVHGYGENFLRCERTRRFPQAPKSDPHSHLFVQPPKEGYQCGKMFFEKKGIQNAANVAREVATHGKSKIFPERYEGRPFKEPCLLWPILKDPNLYRKGKPGIYRVALTLDFKVISAVIRVEDQVVACEEKIKSSKKKNHDSSNYLCYDIVLTHLHLVRAAEAGCARLNTPKPYFYPARYRGPGFTREARLDGVKKYFIFPALKEGVYYKNPGKYRVVMNADCEVIGALTTDIRSKKNLIKCYRLGDGPLPDGYFSQNEPISEERIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E5</accession>
    <name>A0A0B1P0E5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mfs sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003657">
        <property type="protein sequence ID" value="KHJ30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E5"/>
    <dbReference type="HOGENOM" id="CLU_061436_1_0_1"/>
    <dbReference type="OMA" id="GRPFPSW"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="276" mass="29587" checksum="EF650FF950213C70" modified="2015-03-04" version="1">MMSSYFSALLTTTTARVASLRQNLLSTEDDGETEDDTHLCRVLRSYYTENDRPFPAWLPPDPKAAPPVSSQSTNAQSNIGSKYGGIGSQNSASTSFASLFSTGNEQPTTQETPNLRQGRGQSRMKQEANSGEKSNFYSRVNSGMDSSKVQSRPLPSAMAGSYQTANAGFKGNSQSSQSQINPSGRPMTAKDRLKSGNFRRPDPRMTNSAESKSYKNTGSNISDKPFIAATSPWSSNEVEFSGAGYDPPPKAKPRGLPSGPASGRRIGLPSGPRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L1</accession>
    <name>A0A0B1P0L1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004438">
        <property type="protein sequence ID" value="KHJ30344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L1"/>
    <dbReference type="HOGENOM" id="CLU_2672943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="75" mass="8423" checksum="A04D9A2490EFE430" modified="2015-03-04" version="1">MELSSTSDATNGYQCAHEFFSDEMLQDALQIAQETKGNNLVYPALYRGNLFPGNDGYKIWPLMKNGKLYRSGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P0</accession>
    <name>A0A0B1P0P0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003548">
        <property type="protein sequence ID" value="KHJ30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P0"/>
    <dbReference type="HOGENOM" id="CLU_1235842_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="25527" checksum="49DB8FBA11113F5A" modified="2015-03-04" version="1">MIPLSIEDKIDSQRQLRAKSLGLGPCIRFSKDAREVLIGRSPVSKNKAHRRFITRKMPNQKTVATISNSVSHPQRAKKTYQNPKIVIHQRSRDQVCKKRRVKLCRRMSSFGSLRRRITSFSFPGVISRVISTDTNNSASLESSEVASEKSSRRRSIGLSHISSRLRNKLRRDHKPFQSVITMDKSITSDEVSYHLAKNQEYSKSYLNQQKTAIESNSTNVATLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V3</accession>
    <name>A0A0B1P0V3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004003">
        <property type="protein sequence ID" value="KHJ30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0V3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0V3"/>
    <dbReference type="HOGENOM" id="CLU_010916_2_0_1"/>
    <dbReference type="OMA" id="EGYIFHA"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="592" mass="66141" checksum="9D79FF4D4B32E39D" modified="2015-03-04" version="1">MHRLVEPNSWILLRLTSSSLKIFQAIPNTAITLPKYGSFSVNLLLSRPYFLTYELLDRLPTQKTSLLRLVSALELNSEIIADEDNAMNLEQFTTEKGIESEVTGFSSKPIMRSNREIVDSASRQTLTMAEIEDLKKIGTDAGKGIIEKLISSHVGIEQKTAFSLAKYKLLKTKKYLKRFTVLPVDVPLLTQWMMEEKDAAKILEIREEMLALIGSWANVHFSSIPPSLGSNTNEDKINGRWLVVDETGGLLTASIAERMGILYPKCYTQKPESNTFDDAHDFTPMARTNTITLVHNNTQPNLSLLKYFSFLSDKQSLNMDSNATLHPLSASLHLINWLQLLDPSQDSTYSSPIPLLSAAELSAMKSNRRTAYYRKLRRWKRTQYVVSETLRGGFDGLAVVSQMDPVSLLKPLLPLLRGGAQVCIYSPCIEPLVELADLFSTSRRTAFIQSIPVDLESVESTQAIRSFSDAPIESMSQSSLLLETSLAETIKSDFHPNPKKETDLISSDDFPLNPTLLLNSTVQSARIREWQVLPGRTHPVMTGRGGAEGYLFTGIKVLPAQGRVESRGKFSRKRAVVGEKIGIKDKKLKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P162</accession>
    <name>A0A0B1P162_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003975">
        <property type="protein sequence ID" value="KHJ30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P162"/>
    <dbReference type="STRING" id="52586.A0A0B1P162"/>
    <dbReference type="HOGENOM" id="CLU_1099182_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28718" checksum="27D7165CF06B40F3" modified="2015-03-04" version="1">MAANASHILTKSPYTGPMITFMFGSNRKAYYIPKDFLQNSDWINQCNYNNNILVPELSENVGHAIIHYMYTREYQVLKKYYAGILMSDDREDFRMALSILFASETYHLPGLNELAKSEIMRLKTAFPIPTILQAVDEVFRASNFAMASVSKKWIKNYLKSLMREEFQRDESAFENDILFNPLLDIDLIKTVASCLTNIYRDKIQELNKEVTNLKLKEHDTESTLTLTPVISSAGSRSNTPLGSLTSPASVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D2</accession>
    <name>A0A0B1P1D2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003255">
        <property type="protein sequence ID" value="KHJ31100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D2"/>
    <dbReference type="SMR" id="A0A0B1P1D2"/>
    <dbReference type="HOGENOM" id="CLU_797389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058816" evidence="1">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="39262" checksum="A5147D3C467A5FAA" modified="2015-03-04" version="1">MQIQLVLIAITTVFVSITSSTNFWDVQPAYYDCGSWIFFEKNILEMLSSLGENIDQLGHPFIEPLYNLRPDYRKISIPQELCKGNHLPGLRQECHFSVIIDQMAQIIDVVGQMNNGFFIKCKRVDQLVPQPQPIKLNECNFECGYEIISHNVVHLSLTRAMSNIGPSDLRGTQYHGNLYAPELSYWIYPITEKNRKKSVANVPKYTYYLVLTPTGEIKDVIAKLMHKEFMKCACTTKAPPVVSLDKKKGNYMCGTKLLTKKFMIRTALHAMTFKQRPKRWNDFPKPYDGPGSCSGQSIFPILQKGKFYTGAVGRVYKYFIVLNSNFDIEFAVMKTPKGYKLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D8</accession>
    <name>A0A0B1P1D8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative flap structure-specific endonuclease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002384">
        <property type="protein sequence ID" value="KHJ32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1D8"/>
    <dbReference type="HOGENOM" id="CLU_007575_0_0_1"/>
    <dbReference type="OMA" id="CHSSHEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="510"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="869" mass="97078" checksum="C430AB10469B4086" modified="2015-03-04" version="1">MGIKGIYGEIGAGERIALSKMAVEKYEKTGRPLRIAIDVAIWQFQIQAGRSGSGPAIRTLYYRLLRLIALTIHPLFVFDGPNKPPFKRKKRTGNNGDTISNMLTKQLLQLFGFPYHYAPGEAEAECALLQQNGVVDAVLSEDIDTLMFGSEICLRNWSSEDSKGNKAPTHVSAYYKKDVSDKYGLDREGMILIALMSGGDYITEGIPGCGIKLACEAARAGFGKTLCQLARSDTAGYKLWRETLSQEINTNSGKLFKKKHTSLKIPENFPDIDVLGYYTHPVVSNAAKVLKLKEEIEWHGNVDVPGLRRFVAEAFEWKYRSGAIRFIRGIAPALLIHKLMLRGDTPDSDFSDVILTAMYETEIVRNICGRRKHFSSDGIDELRLIFHPLDVVGINLDMEQEEPKNDFGRNGLAPRNSEGIEEYLSNEDDDRPGVSTRKSSTLYDPTLPDKLWVPRTIARIGIPLMVEDYEDALQDPRKFLKAKSASKKAMANKNFPSEICAKNTKLSKLKDVPRASSKSKKLKSCSSTRPESSPCFDTESQDYLSSEPEIKNLANIPAKLAKSENPKTKSASLISKRSNTNTKSKVFEIEKTNQNSMKSSAFNRIDKFPNQTYGKKEKCIEAKKSPISIETNSSFPNKLSSADKIYKTKSSPVFQINGNCNSNKKSKTNGKNSYDYIYLSGLDNDSSILSHLEDKSHSSRSSSPELPDISTLSLQCRKKIAKILENPPSTQSPVKTSNISNSIRFSSSHINKIHDHLRNDSKSNPKVNHEQKTPGNAKNLLNMTALSSSSPLSDSNSLAQPHNISQHTTPPRKRTILLRKSLPGTWKVVDSDDHISNIKLHNYSDPNEKNIRRVCWRMSEIELLDMTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F8</accession>
    <name>A0A0B1P1F8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01003801">
        <property type="protein sequence ID" value="KHJ30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1F8"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033833">
        <property type="term" value="F:hydroxymethylfurfural reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000947">
        <property type="term" value="P:amino acid catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033859">
        <property type="term" value="P:furaldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="202"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="376" mass="40438" checksum="9E15B0443614DE11" modified="2015-03-04" version="1">MGLPTEGKAAVAWASNENLSIETIEVLPPRAHEVRIQIHYTGVCHTDHYTLSGKDAEGLFPVILGHEGSGIVESVGEGVTSVQPGDHVIPLYIPECRECKECKSGKTNLCGRIRATQGKGVMPDGSSRFRCRGKEIYHYMGTSTFSQYTVVAEISIVPVNKEAKMDRTCLIGCGITTGYGAAIQTAKIEEGSNVAVFGAGCVGLSVVQGAVKNKASRIIVVDINAKKKSWAERLGATDFVNPNELEGQSIVAKLVEMTDGGCDYTFDCTGNVSVMRAALEACHRGWGQSIIIGVAASGQEISTRPFQLVTGRVWKGSAFGGIKGRSQLPGLVEDYMCGNLKVEEFISHRLDFDKINDAFRLLETGDCIRCVINVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S0</accession>
    <name>A0A0B1P1S0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003566">
        <property type="protein sequence ID" value="KHJ30816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S0"/>
    <dbReference type="HOGENOM" id="CLU_1908240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="133" mass="15281" checksum="7A02BE911457B281" modified="2015-03-04" version="1">MLESYTTETLKKFLTKKKKEKKKKKNDTEVPETFEEIEVQQSDENATESNVSDGEVEVAENKLRSTGTNDHIVRFDHLIKEIEQWDFKVVQIDSESLEQFLGKFVEIGSIVHKLSPDDLTIIANMDGDYDGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Y0</accession>
    <name>A0A0B1P1Y0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003468">
        <property type="protein sequence ID" value="KHJ30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Y0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Y0"/>
    <dbReference type="HOGENOM" id="CLU_051938_2_0_1"/>
    <dbReference type="OMA" id="EEPRGWW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="284" mass="31469" checksum="89E6F15686B05B29" modified="2015-03-04" version="1">MATPIDGEAKLSATDHPASPTNRKLKILMLHGYTQSGPSFHAKTRALEKILEKQISSRGNASCLPGYLGGLQLIYPTAPFRLSTQEIPGFLSGSEKTDEDIDRWAWWTREKDCDKYKGLEQGLATIADVIRANDGIDGVIGFSQGAAAAALVASLLEPGRRQIFDQVHEEDDQTLAFPKEWYDLNSMVPNGLKFAVAYSGFQPSHPAYRAFFEPKIQTPTLHFIGSLDTVLDEARSKALVEKCVLEKRKLVFHPGGHFVPNDKRMVSILVAFIFECMAERTNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Z1</accession>
    <name>A0A0B1P1Z1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sequence orphan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003453">
        <property type="protein sequence ID" value="KHJ30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Z1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Z1"/>
    <dbReference type="HOGENOM" id="CLU_054095_2_0_1"/>
    <dbReference type="OMA" id="WFASKPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="178" mass="19599" checksum="3DEF920A137259A6" modified="2015-03-04" version="1">MNKSASEVTREAAKFTTSSIANISLGLIKDSKFVQLFGSQANTLKVPSSSLILFSLRDCLTIFASFNVPTLLGPVITRQFSPKLQHELNGQTIVQFTAPAAIQLLSTPLHLLGLDLYNRQDTNIRWSQRWLMVKKNWAISTVARMARIIPAFGIGGIVNAGFRETLIANIDSEPSHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P207</accession>
    <name>A0A0B1P207_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g3811</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003423">
        <property type="protein sequence ID" value="KHJ30956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P207"/>
    <dbReference type="STRING" id="52586.A0A0B1P207"/>
    <dbReference type="HOGENOM" id="CLU_671204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="105"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="46524" checksum="DED4109B9CBB9DF5" modified="2015-03-04" version="1">MPGQRNRILSVAQLEKQGFSIQWPSHYRDMKLVRSDQTICAIFRRINGRFISVNRDWHSILGHPGQKAQDAALKSAGIAIHKFPLDCEICTKVKITKSKGYGSLRQSSSIGEIIHMDLVGGQKSLTPTITDKSIPNATWFLLAVDNFTAWKWAWPVYSKKTVPGQIGHSLEHLKNKFDKTPKCIHTDSGTGFSNSEFQDLLLSCGIEWQRSFSHAPEQNGIVERNFRTITEKMRALHLQSGLQLRQWPLILKAAINILNITPNTVSLKSSYFAVFQKFPKINHLHPFGCRAFWLEPDQNKLQSKAKGGVYVGTEFSGCHIILNPDTNRTVVRRDVRMHENCFPLKTSVLSLQANNRNILQSSLNGPRVQDWNKAIDKKMENMKINKVWILVPRSGAMGKIMTGKWALKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P284</accession>
    <name>A0A0B1P284_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003304">
        <property type="protein sequence ID" value="KHJ31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P284"/>
    <dbReference type="STRING" id="52586.A0A0B1P284"/>
    <dbReference type="HOGENOM" id="CLU_138804_4_0_1"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="84" mass="9411" checksum="A8D4621EA0278C33" modified="2015-03-04" version="1">MADKLRAQQQLEALQARYVGTGHADTTKFEWTSNIQRDSCASYIGHPPLLTYMAIGLGVSREKVRAQLIERMIQPVGKPPEVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P296</accession>
    <name>A0A0B1P296_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5336</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002105">
        <property type="protein sequence ID" value="KHJ32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P296"/>
    <dbReference type="STRING" id="52586.A0A0B1P296"/>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="105" mass="12068" checksum="E6756588C5DF48C3" modified="2015-03-04" version="1">MADSAKIQDLLSKPRNELTEFEIAQIEEHEFTSGPLSILQTAVRSHTQVLISCRNNRKLLARVKAFDRHCNMVLENVKEMWTETPRTSAGKKGRPVNKDRFISKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2F7</accession>
    <name>A0A0B1P2F7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003239">
        <property type="protein sequence ID" value="KHJ31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2F7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2F7"/>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="OMA" id="WLYFMFA"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="926" mass="106491" checksum="77E39D57907083D2" modified="2015-03-04" version="1">MPSDTKAKLSVPKFGEEPELLSPKVKSSISREKELSPENKRPNIIHELGQEIKDADGTLLTKSILLSSDSASKGSKPSTVPQETVLNDQVAEIQMDHTDSNLFNQKGQTESKKLDTYPQENLQNTKAEDSVAHKKLNPQFSEKMIDEACPGMIHSMKQDSSVNDTKNYTALPTRMTNLNKDSMTNTVEEANKMQPENSIIENPNFKTTYQKIPDFGLSQTMHIQSESVRVSGEMAGIGIQPEISGMTATSDPSIVSELKSIYVNIKKILDLRRKYIQLSSQLNGDNPKDDPNWKIYPPPAEPSWYQKDNSNSEFFPKEKSSKSEKLSRNMILLPEESHTWNRDLSSHLFPVSRSIISQKTRKPGQDIGEDFNLADELPVPGLSEMTFRLDDNGVYQVYENPNSRDQNKPEFIIPSLREFYMDLEEIMNISSDGPSKSYAFRRLKYLEVKFNLYVLLNGYQEVTDSKSVPHRDFYNVRKVDTHIHHSACMNQKHLLRFIKSKMKKCPDEVVMFRDGKYLTLAEVFQSINLTAYDLSIDTLDMHAHTDSFHRFDKFNLKYNPIGESRLRTIFLKTDNFIKGRYLAEITKEVISDLESSKYQMAEWRISIYGRTIDEWDKLADWVVDNKIFSHNIRWLIQIPRLFDVYKSRGLMNSFEELIINIFQPLFEVTKDPSSHPKLHIFLKRVVGIDSVDDESKAERRLHKKFPVPKVWDSAQNPPYSYWIYYLFSNMASLNIFRKKRGFNTFVLRPHSGEAGDTDHLAAAALCCHSISHGLLLRKVPFLQYIFYLEQIGVAMSPLSNNALFLTYERNPFLQYFKRGLNVSLSTDDPLQFAFTKEPLIEEYSVAAQIYKLTAVDMCELAKNSVKQSGYEHIIKQHWLGPNYNLPGIQGNTIAKSNVPNIRESYRHETLIQELSMIEKYTTPVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2L6</accession>
    <name>A0A0B1P2L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sodium calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002006">
        <property type="protein sequence ID" value="KHJ32533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2L6"/>
    <dbReference type="HOGENOM" id="CLU_004979_2_0_1"/>
    <dbReference type="OMA" id="ARAHFHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="902"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="953"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="112"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="844"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114008" checksum="EACBD237C429DA6C" modified="2015-03-04" version="1">MYFSTALNRKEKSRNNYLQSFTFTVICLTLLAILSLGKSQKHEALQKSSSELLYTARLMKRNENCRLVHHARDKCAFIKANCQDEDAGLLSYLSLYYCYLVDFHMLAFGILSLWLALLFTTIGIAASDFFCINLNTVASILGLSESIVGTTFLAFGNGSPDFFSTFAAMNSNSGSLAVGELIGAAAFITTMVAGSMALVSEFRVGKKNLIRDLGFFIVAICLIIIFLADGLLHLWECLVMVGYYILYVVVVCIWHWYFEVRRKRRNRKLAANCQFLNRTNEDMISQQDNITDEESSVGQRPYSDFEDINILEQGPYSDLISCKNNEEFDDSDEETNQSIRLAAEMTSNMRVTRPTGSRRNTITPIRPSLVGALEFRSSFASFMEKSRQLNGPLIQYFDDLPFIDPYSYNNANLGSDVAPLRTRAASFNDATAAKTVESVNSRGRNHSNIDMPVSTTVSQKTLELSSTKQAGLLSAPAGFSSRRSVLKRSSLSHSGCLHKQLPSKTHCVHEDDIPAVKILLASPIKNPDELPDSSNDLSGMLHIDTQHLQVQSPVARAGSHSRQSSTSTFPTYFELQNNTSIRASIPSSPVLPYLNRVIGPSLNEHDQDFQQSSISWWPNEYFPNLNTICSTLFPTLCTWGQKSIWDKFVSVISAPSIFLLAITLPVVESESSEGSSSCQELNKVVHSNSSSRMPSRRGLSGNTPIEVRSEWLAYRRSLENQGNFPFLHQVHGPHSQHASSVGVSRSHSISSRVNEITLARNEFTQNTYGISLPEEWNRWLVSIQIFTSPLFLIIIFWTNSAKKDHHLLVKTIFYSLLGSLITFSILMVTTSATQIPRYRFILCFLGFIVSIAWIFTIAGEVVGVLKAIGIILDLSDAILGLTVFALGGSLGDLVADINLARLGFPVMALSACFGGPMFNILLGIGLSGVYVTVNEANKNQIKNPAHHILYRPYQIEVSSTLIISVMTLLTALVGILISVPLNKWVMGRRIGWSLILLWSISTVVNVGLEISGVLKESGKGINSSSRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2L7</accession>
    <name>A0A0B1P2L7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tho complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003488">
        <property type="protein sequence ID" value="KHJ30889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2L7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2L7"/>
    <dbReference type="HOGENOM" id="CLU_049078_1_0_1"/>
    <dbReference type="OMA" id="QFLHNAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="274" mass="32289" checksum="9E097455708EB21C" modified="2015-03-04" version="1">MADPSAKSTHKIIIMAFFQILEHREEDELHKSRLLNVEEKPFKRVSKRLLAPSSFLTTPSKLPTPPLDISLGDTDLQIQAQVKINEERRQFKEDILFDFSAFESSLIRIQFLRDSNERERERYRADKARILETAQYVRENNAQLRSQLDEARQTLEQRKKFDELAEKITGNRLLRPREDQLANLRKLEEECRELERESKNYKITWAERREKFGRIVEEGMQLRRLIRDEKEEVERREGMAEDEDGENVDSTSRGGQTPKHPSGNGTPRARNDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3G1</accession>
    <name>A0A0B1P3G1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001557">
        <property type="protein sequence ID" value="KHJ33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3G1"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="104" mass="11500" checksum="D0584C626F26CF08" modified="2015-03-04" version="1">MHTEDMYMAATKCRNCGGPHRSDSRRCLARPTRSGTPTKEQLKTYRQAGEREFQAVARAKEAELKAANTEESRSNITDSQNTDSTSSGSKVSIVEDSTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3H0</accession>
    <name>A0A0B1P3H0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative vesicular-fusion protein sec17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001811">
        <property type="protein sequence ID" value="KHJ32788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3H0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3H0"/>
    <dbReference type="HOGENOM" id="CLU_046329_1_0_1"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="32849" checksum="2A44EE2CFDBA9A79" modified="2015-03-04" version="1">MSQDPRALLQKAEKAVAGASGGFSLFGGRQEKWENAADLYTQAANAFRLQKQNKEAGEAFEKCAAIQTDKLNEADDAANTFTEAFKVYKKGYPEDAARCLNVAINHYTSRGNFRRAATHKQNVAEVFENELGDMKRAMESYELAANWFENDNAEALANKLYLKVADIAALEGDYYKAIENFEKVSTASLNNNLMKWSVKDYFLKSGLCHLAVGDLVATNRALEKYRDLDPSFTSTREHQLLIELSEAVDAGDQEIFADKLFQYDQISKLDKWKTTILLKIKNSIEEKGEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L4</accession>
    <name>A0A0B1P3L4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003065">
        <property type="protein sequence ID" value="KHJ31249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3L4"/>
    <dbReference type="HOGENOM" id="CLU_1289799_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="214" mass="24204" checksum="C094031132C2A14A" modified="2015-03-04" version="1">MSNQDPPAPTITQRAAATKSAMHQVRQHHASRKVEDALRIRNGPQVTHLYGLPINSPVLVWRENRGWTGPYSLLNITGQECVVDLPKEPTTFRVTVVKPYYIKEQNKDNSKVDISIPDELNMKVSSMTIQQPDVRPENGISINDVVEKSSQPNTRPENIYDVYDSYNTSGYLLPVFRKVALVYEAPSLAVIEVQLGLSQKYLFLEMLMTAHKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Q3</accession>
    <name>A0A0B1P3Q3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002757">
        <property type="protein sequence ID" value="KHJ31581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Q3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Q3"/>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="30657" checksum="B057074E7C018581" modified="2015-03-04" version="1">MANILQALSKYAVPLGVGASLAQASIYDVKGGTRAVIFDRLSGVKDTVMNEGTHFLIPWLQKSIIYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPEVHQLPKIFQNLGQDYDERVLPSIGNEVLKSIVAQFDAAELITQREAVSNRIRSDLLKRAQEFNIALEDVSITHMTFGKEFTRAVEQKQIAQQDAERARFIVEKAEQERQANIIRAEGEAESAETISKAVAKAGDGLILIRKIEASREIAQSLASNPNVTYLPGGGDSSKGNSGGKFLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X2</accession>
    <name>A0A0B1P3X2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002982">
        <property type="protein sequence ID" value="KHJ31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3X2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3X2"/>
    <dbReference type="HOGENOM" id="CLU_412329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="3">
        <location>
            <begin position="434"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="2">
        <location>
            <begin position="614"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="666" mass="75949" checksum="9566758B1C3594FD" modified="2015-03-04" version="1">MSFSGLSKADKEIIAQSSSNERALEMKRLFGMSEALKEDKTAKMRRSRSASANLPLRELRERKLEIDPIKERDESPAPDTELEPDCDNNDEEVIDEEDDEPGASWDKSLKTKVSKLSNKTLLEWNDFVWKPHHTAFLKGVSNWLDYKEDLLIEIQSIGYEPGMRLTPLDEIKLAGAIRRTTTSDARTLIRGMKQGTKIMKLFEATFQQVSELQQDNYWEELSSLKYRGDCPITYVTKFKTAIHNYKSVGGLVPSVQAKNMFKASSLEQLYQDFVAHLYHKTIEKKGNSTLPKNDKGGSIYRTQRGPDGDQRKSGKDFKKRFAKSVECWNCKKKGNYSNKCPDKLAKDKEIKDRSNYVDSSISLLKNKHPVVTESDPAFLYTATVSPSVFEDTVNLYEEELEKRQKLRSLSDMNTANVAQQVLSTRQLSRIADRWLYDTGADVDATNCRENLIPGTIVEIKPGQFPVQTGNGMVHAECMGEVLLSLMGAKGERKTLHLKHVLYIKELPHNLVSGERFYKRGGRQEGNRLINFDGTTLTYIDVERRGFFLWLHGCPEPLKSLSTSVTTQVLEDENKNSSLKKKFELAENQEFQAEYKSCVKGGVFKMSDEIMRRLILWHRRLCHPSADRLKWTIMHTVGIDLDVSDVKSLPCEACDMGKSLKYTTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P402</accession>
    <name>A0A0B1P402_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002365">
        <property type="protein sequence ID" value="KHJ32070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P402"/>
    <dbReference type="STRING" id="52586.A0A0B1P402"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OMA" id="WKHQRRT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="54166" checksum="16C1AF2926FC6CA6" modified="2015-03-04" version="1">MIAALPTGAPMIEWINTIPNEGIIRYLGMFNIERLFITSPNGLREVLSSKSYEFVKPSQLVQGLSRLLGVGLLLAEGDEHKIQRRNLLPAFSYRHIKDLYPIFWEKAVEVTEAITFQVKAGGINFDELPEYQKEVTRETKISETEAVIEISEWASRATLDIIGIAGIGQDFKSIEDSNAPLSQTYRTVFKPSRQGRYLALLNNFFPGWLVKRIPVKRNVEIESATALIRDTCRKRIQMKKIKLQEGKLNDYDILGVALKSGGFSEENLIDQMMTFLAAGHETTSNALSWAIYLLCVNPSCQTRLRAEIHANLPSPKSQTSISSSSIEGLSYLNAVCSEVLRYYPSVAITMRVAIHDTSILGHKIPKGTRVIIVPWATNKSEELWGPDAKKFKPERWLPSDTNPHPANGGAASNYSFLTFLHGPRGCIGQGFARAEFACLLASIIGRFEFSLNDQRESIESNLIIKGGVTAKLAEGLFVKTKIVDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P412</accession>
    <name>A0A0B1P412_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amp-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001450">
        <property type="protein sequence ID" value="KHJ33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P412"/>
    <dbReference type="STRING" id="52586.A0A0B1P412"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OMA" id="KCPIVEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="70"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="704" mass="78391" checksum="BED979A426887C47" modified="2015-03-04" version="1">MSDTLTGEAYARFLRIPPPIGSPYSLPIPGSEKEGRTPIYRHWRFVNMPLLKSMNPRILTVHDCFEDAVRKFRNNRCLGSRSWNVASQSYDDYKFITYGEVAIRKGNFGKGLVELHQNLGITDEKYGVGIWSQNRPEWQIADLACMSQSLYSVSLYDTLGPEATEHIIVNSDLVCVISSIDHISALLKLAPRVPKLKLIICFDSLDDGERPGSSKKIILNDIAKDSNIKIYSMKEVEALGVNSKIPFNPPRPNDLITINYTSGTSGIPKGVALTHANAMAGICSARTIATTLPSETLISYLPLAHIFERVAEQGCFMVGSSIGYFRGDVLGLVDDMKTLHPAGFVGVPRLFNRFGSVIRARTVEATDFSGMIARHIINAKIAKLELPPGQATVKHLIYDYILARKLRTSVGLENLNCMVTGSAPLDPNVMQFLRAAFARPFCQGYGLTETYALGTCQHANDFTVGNCGMVAPSLEICLQSIPEMEYLVTDSPYPRGELLIRGHSVFREYHKDPAETQRALLPDGFFRTGDIAEIDNLGRIKIIDRLKNVLKLAQGEYLSPERIENVFLGSSNLFTQVYVHGDSTQSFLVALCGIDPSSFAPYASKILSRNIAAEDIEAVREAARDIKVRKAVINDLDRLGRKNKFNSFERVRNVWLEVEPFTIWNELLTPTLKLKRAQTAKKYRAEIDALYAESLAEETPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P417</accession>
    <name>A0A0B1P417_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002936">
        <property type="protein sequence ID" value="KHJ31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P417"/>
    <dbReference type="HOGENOM" id="CLU_2005591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="14436" checksum="AE2AF47A323A230E" modified="2015-03-04" version="1">MFIDFKWFWARAWHIALRGAKYWKAVTDGPEKEMRHVHRKNESFDEYLVRLELYDDKNDAAHSALLSSVDQDLQKLVCSCDEEPESARVAMRLLKIKNDYETSTSTIESFKKFSESKTADGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P430</accession>
    <name>A0A0B1P430_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative chromodomain helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5296</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001658">
        <property type="protein sequence ID" value="KHJ33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P430"/>
    <dbReference type="HOGENOM" id="CLU_000315_29_2_1"/>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="375"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="473"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="775"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1502"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1524" mass="174792" checksum="B5DB1C13C9C48950" modified="2015-03-04" version="1">MVESPLSTAIILNHKTPYSLSNRYHSAHKDSTITIENLSYNCNPDPSYVATPMVEGRVSPASLSNPQCDFESHDTDASLSPAEGQDASDDADFDIEDSLAAVTTNIDRDCSTSTDSHRPLKRKLGLEDKHIIANPELYGLRRSGRPIQNKPIIESDEDESESDNGLQTHRTKRRRQERSQQSSQLETQVNRSVSESESNSDTYGGLRARNTMKKHRRRQLNTESTVVAHPEKRWNVRKAAQVTAGVYQESEADIDDESESMTPNYSWVDAENPTSSIDIVLKHRLIEPKGIEAEDLTRDDFEYFIKWQDKSHYHATWETFTSLAGLRGFRRLENYYRKVVQKDIYMSRGLDIPPEEKEKWMLDRERDSDALLDYVKVDRVIGSRDNEGEIEYFVKWKALYYESCTWEPASLISEISQDAIDRYLDRCSKSLTSDKEEANPNSRSSHVPIREQPSYIKNGQLRDFQITGLNFLAYNWTKNKNVILADEMGLGKTVQTVSFMNWLRHDRHQEGPFLVIVPLTTIPAWADTFDYWSPDINYVIYNGKEASRSIIREYELLSDGNVKKPKFNVLLTSYEYILADANFLSQIKWQFMAVDEAHRLKNRESQLYQKLLDFKAPSRLLITGTPVQNTLGELSALMDFLMPGVLDIEEDMDLTEEAAGEKIAALTNKIQPYILRRTKQKVENDLPPKSEKIIRVELSDVQLDYYKNILTRNYAALNEGANGQKQSLLNIMMELKKASNHPYMFPNAEEKILKGSERREDQLKGLIASSGKMMLLDRLLTKLKRDKHRVLIFSQMVKMLDILGDYLQLRGYQFQRLDGTIAAGPRRMAIDHFNAEGSNDFCFLLSTRAGGLGINLMTADTVIIFDSDWNPQADLQAMARAHRIGQKKPVSIYRLVSKETVEEEVLERARNKLMLEFITIQRGVTDKEKKELREKAVKAGKIDDPKSSEDISRILKRRGQKMFEQSGNQKKLEELDIESVLENAEEHKTEVPEGMVADGGEDFLRSFEYTDVKIDLEWDDIIPKDQLAGIKAEEERRAHEEYLAKVVEENAPRKAAMKNTAEIEREQRLFKKRERDQAKQDELDEKREALSNRDDPKRELNEKEARNLFRAFLRFGSIEERQDELIKDARLVGRDIGLLRDTIQAIIDESSRRLKEDAARIEAMERENKKPLTKKDKKAVLFDFLGVKRLNAETVVERPGEMRMLRDIITSISDFRNFRVPDASKAANYTCEWGAREDGMLLIGIHRHGYGAWVQIRDDPDLGLGDKFFLEEHRVDKKEERIKGDEKVAKAPGAVHLVRRADYLLSVLKAKYYDNQAAKRAVENHHRNNKKHDRANGHRRQDTRGSISASPAPNSRKSRISDPYQGRERDIGHRNGNQDVGHRYSDSKKKHGDFDHIQKSRYSESSSSKPNDPMMRLLLKPIKDSLKRLQAATTINIKSQKERANVMKIELVTIGNFIETLAQEEEGAALRQSFWEYVVGLWPVAPSPSWSQLDGMYHKILKGNQKNSKGPSGSLGTNGATASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D1</accession>
    <name>A0A0B1P4D1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001363">
        <property type="protein sequence ID" value="KHJ33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4D1"/>
    <dbReference type="HOGENOM" id="CLU_008514_1_0_1"/>
    <dbReference type="OMA" id="TTHHYEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF3">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="3">
        <location>
            <begin position="239"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="59396" checksum="D6E5070921307E20" modified="2015-03-04" version="1">MEPVSQIPTLLPLTRPLNDHTTSELHDLVFNIDSGKSETSNVIYQIVEHLITVRKEKPCSLHYAALIRANASAYFGSAESVRDLLSEMDKFGIIKDSQVYHYALLALAIHPDYLLRMKILSEMRKNWITLSSDDWHHLIIGLIRDRQYEVALKNFEQMLQDNIDVKPWLFDIFMYQLCESEEYDEVFSMLKYRWDHSRSEIRSEIWHFLMDSFGKGLHLEGLKFIWRHQVRLGYLIPSDGMLSAALNTAARYADPQLATSVASFLSARSALDPYHYEALIEAYAKSKDLKSAFRALCIMAKAGFNPDASNTRPLLACLSSDRKLPTHAWNVLDEIHSDGQIITITAVNVVIEASVSQLNIDEAMVMYKKIHTICSGPNTATFNHILQGLSKTVIPSKKEAMFLASEMKSLSIKPDSLTYDRLILICLREKDYEDAFRYLEEMIREGKGKNEGKGWWLREGTAQRCVMTTIVEGDSRGWEILAEMEKRSMKNAIKVRNWAKQNWRAKRTTSNVKEEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R4</accession>
    <name>A0A0B1P4R4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002684">
        <property type="protein sequence ID" value="KHJ31669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R4"/>
    <dbReference type="HOGENOM" id="CLU_1526302_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="19754" checksum="52E90973683E56CD" modified="2015-03-04" version="1">MGFKEQFPVWAERQRSNIRTNLDVSLATLIADITDEARESFHSKDKDLAMLGTSYGKGKGLSNSQYDPGDKGIFNHLRHTTEKCFEDLRNKEARTTRVKRNKSKSEYLKGGTSDDDQPSTFAGVVINAKNSSLQNDSTILTSSFDSILNSSVDSARWIFDTGADRHICKDLDFFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V1</accession>
    <name>A0A0B1P4V1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative c2h2 type zinc finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002157">
        <property type="protein sequence ID" value="KHJ32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4V1"/>
    <dbReference type="HOGENOM" id="CLU_018787_1_2_1"/>
    <dbReference type="OMA" id="NATHMER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="58247" checksum="631114A52FACBD5F" modified="2015-03-04" version="1">MSSTHPYTCNSCQIAFKNSDLQKEHMRSEWHRYNLKRRITSLPSISLDLFVEKVLQAQAHSTAAATKAAFQKTCAACDRTYFSENAHRNHLGSQKHKNNIASMRDNEIEKLSVLSSTFSLGESINYTENMEPEEDETNILNQAVQSTDLGDQIPVYRKPIQIQKATQMKNGTDQASPSPRSSNQVKIKGVNLNRCLFCNLDSQSLGLNVIHMQKLHGMFIPERKYLVDLEGLVNYFYEKINDDHQCIYCGKLKQSIFGLQTHMRDKGHCKIPFFTEEEQLEIGEYYDFTSTYSDDSETADLEGSLPIRLAKIGKAEEADEGWETDDSEATLNLALTNKSSLKHGILENNKTDKETHENQVDHGQMAYLDDIENENFNIGFFSEYELHLPSGRIAGHRSMNKYFKQNLYRYPSYAEREENPLIGALALPENEERGRVSNLGLNNPGTKLSLKNSYEKYGMIGVTAQKKKEIASLEKRYRKVEDRGRRRSEWIVNKQNNSQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V6</accession>
    <name>A0A0B1P4V6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative golgi apparatus membrane protein tvp18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002143">
        <property type="protein sequence ID" value="KHJ32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4V6"/>
    <dbReference type="HOGENOM" id="CLU_118698_2_0_1"/>
    <dbReference type="OMA" id="MAIVQWC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="108" mass="11593" checksum="8F666659C21C8E4B" modified="2015-03-04" version="1">MIIFGAICLASSFLIIFVEIPLLMRICPTSSKFDSFMRRFSTNYMRAAIYLGMGMAQWLSLIGEPSSLLAAAIMLTLAAVFYALAGLKGQGFVGSKTLGGQGVAQMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P549</accession>
    <name>A0A0B1P549_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative intermembrane space aaa protease iap-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g0620</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002059">
        <property type="protein sequence ID" value="KHJ32475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P549"/>
    <dbReference type="STRING" id="52586.A0A0B1P549"/>
    <dbReference type="MEROPS" id="M41.004"/>
    <dbReference type="HOGENOM" id="CLU_000688_9_3_1"/>
    <dbReference type="OMA" id="RATIDVC"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="356"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ32475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="802" mass="87765" checksum="8CC0BA282C2C351B" modified="2015-03-04" version="1">MVGFPIVNMAYQGMLPVFSPSKIRAFRPSKSIVDITATVLGWKKQYTTPRKLQPLAGGLQFDTKNLVNFPPRPNNTSTLIFKSFTRDSTAGLLGYDVFKPRRRVLLQTYQLSSLAALKSRQNSSTLYSTDTSQKRTLFGSASRSTLAFLEESANKFSDDANKQYVFYQALFRANLLPIIVERHQSKKFATNTACENLYHQALGALNPSSSSMNQSRLTPQTGNSFNASQLQAVGQAIAANSQGGNIATSRPPTSSKESPLYVVVEESLGVQIFKWFKFLAIFGFIIYFSLALVTLVIDSLQSIKKVGGKTDSEAKAEQQNVRFSDVHGCDEAKEELQELVEFLKNPEKFSALGGKLPKGVLLIGPPGTGKTLLARAVAGEAGVPFFFMSGSEFDEIYVGVGAKRVRELFAAAKSKSPAIVFIDELDAIGGKRSARDSNYAKQTLNQLLTELDGFDQNSGVIILGATNFPESLDKALTRPGRFDRNVVVDLPDVRGRMAILKHHMKKVVVANDVSIEVLAAGTPGFSGAELENIINQAAVRASKAKSSQVSMLDFEWAKDKLMMGAEKRSMLIPQKEKELTAYHEAGHALVLMFTKGANPLHKVTIMPRGRALGVTFHLPEMDKYSKTVEEYRATIDVCMGGKVAEELIFGAEKVTSGCSSDLTQATQAAYSMVASFGMSEKLGHVDLASNYESLSAGTKQLVESEVRRTLEDGYERAKKLLISREKELHLLAKALLDYEMLNREEAFKVIRGEKLEGKTIMPRASIKIPDLSVDITPTIPSLPGTVIQPPAGKEPPHGDTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P9</accession>
    <name>A0A0B1P5P9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dnaj domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001098">
        <property type="protein sequence ID" value="KHJ34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5P9"/>
    <dbReference type="HOGENOM" id="CLU_073129_3_0_1"/>
    <dbReference type="OMA" id="VFQSTMG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="24237" checksum="FAA86E9597CC9BE7" modified="2015-03-04" version="1">MSTNEPLDYYAALGVASTATQQQIRDAYKRAALKTHPDRLPPDSPERAKQTLKFQIVNDAYYTLSDPGRRTDYDSTRKYYGFDSGASSAATGDAPESSSSFPWSNFGFGSKAKTEEEKERFQSEQFGDVFEEMLRDEGLAGDENKPTGRFWSIIGGFSGAAMGFIVANFPGLIAGAAAGNRLGAIRDKKGKSVYEVFQELPASDKAKLLSVIASKVLSHSMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q4</accession>
    <name>A0A0B1P5Q4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001903">
        <property type="protein sequence ID" value="KHJ32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Q4"/>
    <dbReference type="HOGENOM" id="CLU_1200585_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="25800" checksum="98E17617AC5598FC" modified="2015-03-04" version="1">MAFGFVDDTNLVAWGCSARENCYTLKLAHSKCLAWAKRYGAEFAPGKYQLIHFSRKRGSSEDLKEKIELEDITINPRSEIKVLGVLVDSRLRWTHTLYFATYLTENRITLLIFNSRYLGNETMAPLANKHTLPPEPPDAGNRVSKTKKSSSKSVADVKSIRLAAYSAEAFRKAEAIEKALRVSQCSTEEIIGTEDNIMYEEMSDASDSVFGGGTQRAAIPQCQTETHNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P668</accession>
    <name>A0A0B1P668_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002081">
        <property type="protein sequence ID" value="KHJ32436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P668"/>
    <dbReference type="STRING" id="52586.A0A0B1P668"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_3_1"/>
    <dbReference type="OMA" id="SRWHKDY"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="35149" checksum="8F97F77598C27EF2" modified="2015-03-04" version="1">MSSTHPVFRPGNTAVITGAASGIGLALSRKCVGYNMTVVMVDINATNLEAAKLSILKENQTNLLEKHMNKSKNVEIVVMDVAKIEDYEALKMLIQDKFEGKISLLALNAAILDKSNWADTAYFRRVMDVNLFGVIYGLNTLLGLVTKHSTNENPAAIVITGSKQGITNPPGNPAYNTSKAAIKVLTEHLAFDLSKLSPFTSIHLLIPGWTFTGITGNRAPHESSGQHSTDKPAGAWWPEQVVDYLEQKMSENKFYIVCPDNYVTEALDQARMQWGANDLILGRPPLTRWKEEWKSESESWINEKAAEIAAEIASKSQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6E7</accession>
    <name>A0A0B1P6E7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peroxin-3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000976">
        <property type="protein sequence ID" value="KHJ34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6E7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6E7"/>
    <dbReference type="HOGENOM" id="CLU_017002_3_0_1"/>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="527" mass="59471" checksum="8BBB53A7875AC2E0" modified="2015-03-04" version="1">MISASRRWFRRHRTPIAFGLGVIGFGYIATQYLLGKILEARERINNDRIARENLRRRFEQNQEDCTLTVLALLPTAADNIIAELGTEKITYELQQQKAAKFARTGAAHQNLISSEVPSLTDEDGRSITSLQSESGVHASQVVIPSSVEAGNNTLEGTETDQKVKKSKLQLWNELKISAITRSFTLIYTLALLTLFTRIQLNLLGRRSYLSSVVSLAASGMDHQSIISLENHDDDNSEQVYGSDFETNKMYLTFSWWLLHRGWRDIMLKVEAAVVNIFGSLSPRDELSFDKFSDLTLKVRKIIEGSTPFDRQQNKWLKYLLPPRDQEESILEESGIKEKEASSTPPTYLIARNSALRRLLDETSDLIDAPPFTHILTLLLDAGFSTLVDQKISQQVYKFSSISKAPNVKVQEIMDEIPVKLPIILAVLTKQAHAMGRGAPNEYLQSMEKVRELEAFAAVVYSSNWESLINPMHTDGFNQIGEPTSMSDDLVNVSRMEEEESLIDIVTANKFESIWEKAIMNPDEDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Q8</accession>
    <name>A0A0B1P6Q8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative adipose-regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002174">
        <property type="protein sequence ID" value="KHJ32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Q8"/>
    <dbReference type="HOGENOM" id="CLU_043048_0_0_1"/>
    <dbReference type="OMA" id="HSKQVQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="45307" checksum="BAA4207C9EF5373B" modified="2015-03-04" version="1">MINKVQQELVSNSLQLAASKPARQTLICTFLITATTSILLGIAVFAYTLFYCNFIPQIEIQKVIHLQYGDGPHPYGIIPLGSELISRQAYDIFLSLSLPRSPQNLARGNFMTTLALLRPSHKFNTSHFQKLGISDMNSPMSLLGAEDVLAVFRRSAIMKYTSHLVSLSSRIINLPLYMLSLLSEAETLTISIGEGVTFPRGWKNIPSLALLEIQAGQDIQIYQAAILFKAKFSGLRWLMYNHRVISFVLFTGLFWISTLVFATLTWATLSIYSAPKEKVMKKISEDSLEGSSNKVEELITDDDPEIKTEEVTTDDEPDLSDTPRIFPTYGRQPPLRFDPKVKNVIDEMEYSQIDPILKEEVYYEDQGEYIGTTIISKTDSGIGTSLSESKNKKATNRKLARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W6</accession>
    <name>A0A0B1P6W6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001627">
        <property type="protein sequence ID" value="KHJ33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W6"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="179" mass="20168" checksum="D1B88FE373B5CCD1" modified="2015-03-04" version="1">MDTDTDVSALPTDMCPTPPSSTISIILPPHSTPLYFTYVNECNTHSIRHTLTPVAPSKRAAQKTATNQASQLLDDGSGQMYSYLPKDIRKVIEKRRLRERAWRARLSIYTSVICNIESTLLVYKNDIEKEEADLVRNYLQQAIALLAASDNAAKSPPIPHLTKPLKTKRLFLGERFNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z0</accession>
    <name>A0A0B1P6Z0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative qde2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001880">
        <property type="protein sequence ID" value="KHJ32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Z0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Z0"/>
    <dbReference type="HOGENOM" id="CLU_004544_4_1_1"/>
    <dbReference type="OMA" id="FGIFNQC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="397"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="677"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113106" checksum="3082158298F67261" modified="2015-03-04" version="1">MSDWGGSRGRGGRGGPPRGGGRGGGYGGDGGYRGGGGGYRGGGGGYGRGDGGGYRGGGDGGYRGGGGGYRGGGGGGGGFGGSMRKEQKVFSDPNAPLAPADSQLKQLEDTFMANAKNMGNSATASLDSNLPLRPGYGTQGKPISVYSNYFKIDVPQDLRLARYNISVSPEAKGKKMARVVSLLLERPEFSKVQTRFATDFKSFLVASRPLTDMPAQWNIRYSPEGHDEAGEEAKVFIVKLQEPAFFSVSNFVKYLSSANVKDNFNEEEQKSIIQSLNVVFGHYPQSHPGVVTVAGNKHFSLARGENNINIRPLGDGLEAYRGFVRSTRAVTGGILLNINVTHAVFFETTNLAALYKKMGTQNRVNLKEKLKGMRIQITHLPPKINKTTGKVIPRIKTIQGLANINDGAKEEHRPEVAGYGAGPQKVKFWVSEDTGTSKTSQKNPLPSNTYISVYDYFKKRYPKIELDPINPVVNVGNSEHPSYLPAEVCQVLPGNKVNRRLSPRQTQEMIKMACRTPYENAESIVRDGKSILGLNPGDKSTSSQFGLNIGKGLLVVNARTLHPPSINYKGARVNVSNGSWNMARQKFHTNAQLGTWSFVLFKPPPSNSGPRLEEDKIRRSVMGFRDFLEGNGINAKGLVPNGVAVDLIGGERATQVNTETTGLLFKRMCESNNKPKFLLCVMAADDPSLYNIIKSIGDTRAGIHTVCVIGSKFTKEKGQGQYFANIALKFNMKAGGINHILDPAKLGVISEGETMVVGLDVTHPSPGSKLGTPSSVAMVASVDKFLAQWPADFRIQMGRQEMVSDVEGLLLGRLKLWRQFNKRLPKNIILYRDGVSEGQYGMVLDDEVPGIRKACRQVYSPDETKQGLPHLSVIVCGKRHNTRFFPATLAECDRSSNCLPGTIIDRGITMNRTWDFFLQPHACIQGTARPCHYFVVLDEIFRNRALKAPHQNVADSLEDLTHNMCHLFQRATKAVSLCPPAYYADLLCTRLRCYQADKYDPSDEESAVGSIQGSAPLATPALVAPSIHSQIKDSMYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P722</accession>
    <name>A0A0B1P722_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EV44_g2960</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001863">
        <property type="protein sequence ID" value="KHJ32711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P722"/>
    <dbReference type="HOGENOM" id="CLU_000907_4_3_1"/>
    <dbReference type="OMA" id="YHVNRMC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="164"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="492"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="23">
        <location>
            <begin position="693"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="20">
        <location>
            <begin position="936"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1102"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1300"/>
            <end position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KHJ32711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1591" mass="181816" checksum="968BBFC51BBCA87E" modified="2015-03-04" version="1">MAASVDIKLDGDVAPTLTPRTKEDLIADLRTLVPPSKKLWRGLIKIEPDSVTQQETSVANSIPTTNAKSENAQQIEAEENIIYDPDDSSEDEVIRITESQKVSQNKRRQDVVAAEYMKDINKKLVKEKNKVQSQDVSDQSIKWLINQSESRMIISTPREYQVELFDRAKARNIIAVLDTGSGKTLIAVLLLRHILSQELEDRAIGKKKRISFFLVDSVQLVFQQHAVLKANLNAPMEMFCGNMGCDLWNKEQWEKHFVENDIIVCTAEVLRQCLHHSFIKIEDINLLIFDEAHHAKKDHAYARIIKDFYAREPSDSRRPRIFGMTASPVDARVDVRKAATELEAILNCEIATASNGSLFQTGSKNNGRSEQLGRYAALVPKFKTPLYQQMHQCFSKNLILTKPLRFSYEASRELGAWCSDQVWVFCLSDDETKKLLAKSGRLGLSSKVEPNPDLIEQSRSQIQEAKIIVNSHVFDPPDYSDDRSWSTNLSSKVVLLIRYLRERYERETNDKCIVFVKERYTARLLARLFEQNAIRTEYLHVGTLIGTRSDDASNLNTTFRDQVVTLIKFRKGILNCLFATSVAEEGLDVPDCNLVIRFDLYSTLIQHIQSRGRARHPNSKYIHLCETGNQDHSHIIMEVRKNEGILRQFCDMLPEDRKLHGNDICIDDILAKEKYNRVLKIPETGAQLNYKMSLVVLANFVDKLPNSGEGNYQVEYVITSQGTRYQCEAILPETSPIQGTVGHWASTKQIAKCSAAYETCIKLLKGKYLDNWLIPIYTRKILPAMRNAKLALDSKKKSAYSMRSKPKFWTADGTPGKLFVNILYLEDPDAMDRPTQPLAILTRMALPQLPSFFLHFGKGKYSTVNCKPIDFISLGDDLLEQLNTFTLCIFDDVFSKGYESDPSKMPYFLAPLRTGIEVRELNTDLFSNIDWSTIENVNDHQRKWSQDPWTNFAWKNEPDEYFNDKFIVDPFDGSRKLWSIGVTKEYKPTDPVPPNSAPRHGTRKNNNNIMEYSCSLWAKARSRRTFEPDQRVIEARYISLRRNLLDEFDTQDDSVPRRCFVILQPLKISPLPTKIVAMAYIIPAIIHRVDSYLIALEACELLHLNIKPDLALEALTKDCDSNQKDGKDEIIFQRGMGNNYERLEFLGDCFLKMATSISLYGLQPENNEFAYHVDRMLLTSNKNLRDNAIKLKLYEYIRSQSFNRRAWYPEGLVLLRGKAAKVKDSHDLADKTIADVCEALIGAALLSYHDTKNMDMAVRAVTELVSSQFHSVTTFSSYYKSYKKPVFQTQKSTQAQLFLASMVEKQHPYKFRHPRLLCSAFTHPSYPRSYNENIPSYQRLEFLGDSLLDMACINYLFHNFPGKDPQWLTEHKMAMVSNMFLGALCVKIGFNQHLLVFNHTFMKQIEEYVVEITDARDQAEKEAIEAGKSPDECSPDYWMSVRQPPKCLPDIVEAYVAAIFVDSEYDYSEVEKFFDMHIAWFFRDMSIYDTFANNHPTTFLANLLGVNMGCHAWSTKVGDISSVEDTKATIVVMVIIHGTVVSHAAGESVKYAKINASKKALELLDGIGLGEFREKYNCDCHNESQLMEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7J0</accession>
    <name>A0A0B1P7J0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aaa family atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001741">
        <property type="protein sequence ID" value="KHJ32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7J0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7J0"/>
    <dbReference type="HOGENOM" id="CLU_000688_15_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="401"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="657" mass="73786" checksum="D2499C0D831810A5" modified="2015-03-04" version="1">MEVPLEKQHQSLGPEKKRTMKHTLRTSDSRKAKPSRCISKDENLFTSKAASIAWNSVGKPTHENVSIINQSLGHNESKSRSDLCQKDHHSEISKYKDKNPSPHTLLDGYTQIPIFHNASNQKAPLVNLEKYKEIKYSSTSSFKNVKFPKRYSALQSLQEPDAPVLIQTESSIPRPKKTPPLIHRSYSSPTPNALALCRYEKDVNVLGSKKAAISNATFSKIGPVNNLDSKLETTTSSSRNSNKTYTHDSLSRRGGYHYRIKNNGKVVIRHESHSLDARKTSQISGDDTLPSINRKFLAREKIYMQKKNSNTKELENRDLYESTSSTQSPNSNIDVKPYHLKSLPIGVDEEVARQILNEIVIKGDKVYWDDIVGLEVAKAALKEAVVYPFLRPDLFIGLREPARGILLFGPPGTGKTMLAKAVATESKSTFFSISASSLISKYLGESEKLVRALFQLAKALAPSIIFVDEIDSLLSSRTGQGEHESTRRVKTEFLIQWNDLQRVSSERNSDQKEIYQKDAHRVLVLAATNLPWAIDEAARRRFVRRQYIPLPEINTRISQFQKLLNHQKHELDEPEIQQLAYLTQGFSGSDITALAKDAAMGPLRSLGDAILLAPIEEVRPIKFVDFEASLASIRPSVSIEGLQAFEDWAKKFGERGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7T4</accession>
    <name>A0A0B1P7T4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1636</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001666">
        <property type="protein sequence ID" value="KHJ33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7T4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7T4"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="422" mass="47327" checksum="8319EEAE93B3DFDF" modified="2015-03-04" version="1">MMGDVMVPSLPGISQSHKKSFPSSMPNIEALEVLESDGADEYQTMKKLQGHLEYLQLQEEYIKDEQRSLKKELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYFVRILSTLDREKLKPSSSVALHRHSNSLVDILPPEADSSIAMLGQDEKPDVSYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPNLRDRRERRLIFTTIASKMSLAPEVDLDSLIVRNDPLSGAIIAAIMQEAGLRAVRKNRYNIIQVDIEDAYSSQVKGAIEKNKFDFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X5</accession>
    <name>A0A0B1P7X5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">EV44_g1781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7X5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7X5"/>
    <dbReference type="HOGENOM" id="CLU_061241_2_1_1"/>
    <dbReference type="OMA" id="WFEMINT"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="180" mass="21067" checksum="2CFD5F3EA85E0A72" modified="2015-03-04" version="1">MLASPTGRRILRDRPRISSETICLSHLRNLPENSMGRTYAEWLDREGVSPDTRDQVKYIDDEECAYVMQRYRECHDFYHAITGLPVVVEGEIALKAFEFANTLIPMTALSLFAVTRLKPKARKRFWSIYFPWAIKNGIMGKDLINVYWEEELERDVDCLRKELGIQKPTDLRNLRAKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P807</accession>
    <name>A0A0B1P807_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001624">
        <property type="protein sequence ID" value="KHJ33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P807"/>
    <dbReference type="STRING" id="52586.A0A0B1P807"/>
    <dbReference type="HOGENOM" id="CLU_014926_1_0_1"/>
    <dbReference type="OMA" id="AFHSDIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="650" mass="74332" checksum="894A2DDF95105B00" modified="2015-03-04" version="1">MSRWFGGASKAQKPLIASVEEAHLRQVQDALLLLLNDDIVSAEKVLNSADSSYHLGGQGISKFISSMLGAESELLKDASKTIQEAESRAWEDIKRAQKDSTAFRSRIYPPGTEYLLCYAVSLLTGAICAVMSGSVVQAISGFTKLRKAFLILDGIMEIEVTYFEKYKPAGQSTSIKSETTPRDNNSSAKANVLDPNRASISIDSESLELSNYNLKICEITSYTDTFIHSGTRLCYGILLVVFSMIENPIFTKILYLIGFKGDRKRGMLYLWQSSRFNNFNSAIAGITILMYYSGLIGFCDILPTDDRADEDLSAYPRTKIQNLLSEMRTQYPESKFWRLEEARLLAFNRNLTDAVKILAENSKSNFKQISTISTFELALSSMFHHNYELMAKSWIQCEDQSSWSPTLYAYLTGAAYFELYREKKKKDPAIAKELKQKAITYFRKGPPLSGKQKLMSKQLPFDMYIVRKCQKWEERAKAWNIDLTEAIGVSPLEEMIYLWSGSKKQNLDELHKSLNVLSWDRTDLPEKHKSNLDETAVHAVLMACVYRNLEKYQEAREILQKNVLCHDKQIFKGHLKDDWTCASAHYEMACIAWQEKDLKDQDHKAKFLECKEWLEKVQKWGDQFILDTRLSMKMTTSMATLKRHQKIMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P867</accession>
    <name>A0A0B1P867_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000863">
        <property type="protein sequence ID" value="KHJ34453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P867"/>
    <dbReference type="HOGENOM" id="CLU_071130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="245" mass="27374" checksum="BD827730D787DAA4" modified="2015-03-04" version="1">MVEQKKPTKTIDLTAMPTCQHKESTQIYQAASANKDIKYKVASKNSWTEIVRRGPKKQAEDPRRQEKAKSSTISPEMTTRAIPEPDKRLFLRMGQDHPWRRVSPHYIKISLAEKLKVASSVITQVTRVNSGYAVTAVSEIMQNALLIQTHRLETSELKLELVSKWVSLLAPNVPDKLFSTSGTVPVTAEIVIEETFLKTGTRPTSARAIALTSESPTTNWTLHFSTGVPKLGESLFGEIGRQTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C6</accession>
    <name>A0A0B1P8C6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative vacuolar import and degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001741">
        <property type="protein sequence ID" value="KHJ32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8C6"/>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="OMA" id="RLNETKW"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="255"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="450"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="839" mass="95911" checksum="975075F17F71254B" modified="2015-03-04" version="1">MFVLRNVGKFLFGSTSRDTIIELPQGQLYLVRPSSPKSYSELIFKDAAARIQRTNQEHQFQLVIQRAYEEGEEDLGEEDDDGNPEQATLAAERDEKTFLLDKILHFRSEVREGGDKILAWRDLSGDNGDIYQFVCDHSIDDDLVRNFEIIARNCQYEREHRKSYQTATKQDLAKYCFDSEYTIPCVSSIQSPINYSPTHSRISLQSDDRIMSKSYRRDSERKSLSRNTESSEISNQSIVKVEPPEATESPEALSTLCRETAELHLFDFETGAFILQDSIVDAIVSEIDNWKYWIEVSTKDKIWVGQSVIADINPVFNFEFLSFIFNAYSDNGDAYSWLLRFQDVEVMTRFQEGLMQALWQNLNEMRWESSKDNDRDYVLEAFQDLAVKDSLDEEEEGEDKEVYEESEKQEQYYQEERESEEEDDNDAQKSEEYDTDEELDNVSVKPNDGNENSLLAVGYKNDRSFVVRGSKIGVFKHTPNNLEFATNIARIETPGGKLFSPKKVMLHEEDSSLVLQNESNPHSLYRMDLEYGKIVDEWNIHPDIKVETFTPENKFAQMTSEKSFIGISRNALFRIDPRLSGQKLVDSQLKQYVSKNDFTATATTEKGYIAVASNKGDIRMFDRLGINAKTQIPALGEPIIGLDVSANGRWILATCRTCLLLIDALQKDGKNKGKLGFEKSFAKDSKPQPRRLGLTPSHVAQFQHETGFPLSFRTAHFNTGEGHEETSIITATGPFVVTWSLKKILNGNKEPYTIKRYTEEVKADNFRYGSDKNVIVTLPNEVNMVAKNSLRKPTRESIMTPTRISGSGFSGRRTDFGRMSTRTSNGYKFGRDDIVNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P902</accession>
    <name>A0A0B1P902_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0191</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000490">
        <property type="protein sequence ID" value="KHJ35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P902"/>
    <dbReference type="STRING" id="52586.A0A0B1P902"/>
    <dbReference type="HOGENOM" id="CLU_007952_1_2_1"/>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="15">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="425"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="763" mass="86750" checksum="ED789C07ED52E9EC" modified="2015-03-04" version="1">MFVLTGLGNLCWSAMIENSLLLWHYYRFSIILTAATVILFLRVILHLRTAKKTYPDHKSIDVVHLPALISEGKGNFVDETASKPGKSPRRIIGGLKESLTAQKINIGCQKIQCFVFFSSLTGTTKNTAKIFVDSLARSLLKIKTFQTRIFLDSEVLDLSEIDFYDFFLKSPNDNDAEIRNFYLFLLPSYNIDTILDNFIEHLKETHNDFRINLAPLSSILGYSVFGFGDREGWPTENMGFCSQARHVDKWMARLTGGKRAFPLGMGDIKTDGQENLEKWTEGVLDVLKQVASTGYLGEGIAGSGDADESDLEETDTEQNLIEKPRPRKITPERQLKKYAQNDLEDIGLTLNVDATNNALQEIDFTTYSAKLSPTIKEMVPKDSPTHTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWRVDPPELIYSGVKASHYQKIKMMRGVPGVRAERFTEAMNIRHCALSLVGEPIFYPHINEFTALLHADHISTFLVCNAQHPDQLASLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRHRRFEQRTVFRLTLTKGFNMEDEIVGYADLIEKSLPCFVEIKGVTYCGSNTSKAGVGLTMQNVPFYDEVCTFVQELDRELSRRELGYGIAAEHAHSCCVLIASKRFQRHGKWYTRINYDEFFRCLESGKKFGPEDYIGLETPEWATWGKGGFDPRDERVYRKGKNKVPLSLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P988</accession>
    <name>A0A0B1P988_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Threonine dehydratase</fullName>
            <ecNumber evidence="14">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1402</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P988"/>
    <dbReference type="STRING" id="52586.A0A0B1P988"/>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="16">
        <location>
            <begin position="389"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="16">
        <location>
            <begin position="487"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="568" mass="62791" checksum="FAAAF7A477D44EAA" modified="2015-03-04" version="1">MGDASQDGLQPLESNRSRTPSLNSLSLTEYSSRPPAASQSLINDLKMVVPDEYLLPNGYPDYLRLILTSRIYEVVDETPLTHAVNLSNRLECKIFLKREDLHPVFSFKLRGAYNKMAHLNPEVSWKGVIACSAGNHAQGVAYSARKLKIPATLVMPEATPSIKHLNVSRMGATVVLHGQNFDAAKDECARLEKIHGLTNIPPFDDPYVIAGQGTIGMELLRQANLQKLEAIFCCVGGGGLIAGIGTYVKRLAPHIKIIGVETYDANAMIQSLSAGERVVLKDVGLFADGAAVRTVGEETFRLCKEVVDEVIQVTTDETCAAIKDIFEDTRSIVEPAGALALAGLKKYLSKNPSTDINRQLIAIASGANMNFDRLRFIAERAALGERKEVLLSVSIPETPGSFAELIERVMPHMVTEFIYRYSSEKIANVLIGISLVSSASQRDQELNSLLSRIRSGDMTVTDLSGDELAKSHVRYLAGGRSNVADERLYMFNFPERLGALEKFLKILRPKYNISAFQYRNTGSDIGKVLVGILCPEAEVKELERFFRKIGYHWEDCTQSEVFRTFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A6</accession>
    <name>A0A0B1P9A6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative copper fist dna binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000680">
        <property type="protein sequence ID" value="KHJ34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A6"/>
    <dbReference type="HOGENOM" id="CLU_036162_0_0_1"/>
    <dbReference type="OMA" id="YTINECN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="58921" checksum="D19350E93209655E" modified="2015-03-04" version="1">MPLINGMKMACEPCIRGHRSTKCNHANERLMVPVRKPGRPLSSCPHLKDHLCSCNSITAAIPRKQVCQCSISSSTKNTNVAARATPSSSVVMPLSPGKPTFRIDKIYQKSHLKRKSSGVTNLERMNACQFHNHQSLTNRHQIPTVSSNGYYVSQFPNSTGHHSQTSPSIVPQPLSTNGICQVGESSQYCNGNLDNGDSFTINQHHEIRPDFFSNGANISTEQSPISDENLSDIMNGGKRSPKKGKSCCNFQEITYRNEKSSTNSRSMVRKNINGDGSLSPTEGDCCFLKCMDPTNTSSTGFFTEKKESDVTNGCCIETSKILNQNIVSQVVTQNSLPESIGYNNQFYAYPPPVFSYHTATYGSFSNPLNVSTWRQTHDNIFHNARGENQVTEDYATAPEPEIRSFVKSCNCGDACQCIGCVSHPYNDATQDYVRSAWQTISLEGNSSEPYANGGQSLNEDQRAISQQNIENKSNSNPPTPSSSSTNGEEQSLPENNFLFVNYSFPSEESEGDVFNYGCNNDCQCIGCDIKRRNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9G0</accession>
    <name>A0A0B1P9G0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative vps9 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000438">
        <property type="protein sequence ID" value="KHJ35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P9G0"/>
    <dbReference type="HOGENOM" id="CLU_002294_0_0_1"/>
    <dbReference type="OMA" id="HFPMIAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="349"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1321" mass="149808" checksum="80E2CABF43F4FE84" modified="2015-03-04" version="1">MQPLNPFIRAFFKSSLPLQCTPAHDFILLVPTTEVLLTSCDQESGVSYAELAVSEEFLGSHVLRIPTQHVGAWEESPNMRDTRGKAKQYPTLNGKLVVVKDSFVYSNKGFKSHNQAQLLTDILFYPDSIEPRQWLIYYISRPLVGTFQEVVVPIAVLPKSPTDKKLSPEACKNSWEDELAIRDGFPKKKQIKLFNELLSNYPMIARQMQPGLENLFKEFNLVFEKPLPPPPSAEVIPDPEPPTPNTANFMAIRLNSTKTVPNFRLNTHSGQSVIQVLDSEDEEQIMRSALETAVTSAIDLFQMVDKQQLSLLGATTDLTGPIVERLIERYVTEQVHESILHPRLCALKKAEDLNLESMIKQMAFVDISQVGIPIQGGQRGKHELTLRLGRAVDEFNKLNAAGSPQQMMDILLSTLKTVSRLTETQNVSITEETQSFEKSNPILTINADSLVSLLLIVVVRAKVRHLQARLSYMRYFIFIDDVEGGEMGYALSTLEAVLSYIMHNSAGLRKASAKNKSLWQATKQGNIQELVSILDPNLENLTRDFEDQENLSSDDRVQNMPQYFYGRKPRQDSFYFEKSKLTLGHVFPWQNHDEESDQGPELKKQKTVTIDMRSLSSSSEASFLTRASTTDSVNIGFEGDISIERLSQTQDLSGESILMMAVQNKQPECLEYLLSLKNYFPSDFVLGDVNNEGTTLLSAAVQLGQNNLIKIILDFLFGLETPNSIKDYLSLQDIRGRSVAHYLFNATYLLTIFGPILPWRQKDRNGQTPLFAICRSYDHRDYRLMVENALAVAMASQDNGEPLYLDDHVDAKGNTLLHIINDPGVANRILLLCDTDVNATNHKKFTPLMVASKYGRLELIRVLFGDQRIDLHAREYRGLTAVELAKDDDVRNRIDDLTLFQGQPAADGRLTSVVRSYFVQDATIRIILKSGAPTNHQSYTITTCRRSLTDFNHLANLLALENPASWLPSISRMRNPFQLISKPSKAILRDIQIRLDSFLKILLSHSTFSTHEMLWEFFLVPDIQVDMMEARSKLKMQTRIEKVREEFEPVEDIRDVEQFVDHARDMVRSVNHTTKSVARRANQMLISTTDLYDSFCFALRIFLGFEGIPIMYTNALQAYVACLEPPSIHPYANFHSAVLSIHNTIISMLLALSHPNSLIASISTINKSIERSKNSLSRSTRWPLGLLDETRQRLNEEKEERVRKEKKEVEEVGRELRYTWSVVAGELAGWQDSHENMSKRAIKELVKGMVIREKSVLQGMKRALRRINLRTSNAPHPDSQLKKSCYIYDSGPGESRLRRKEEILHAVDSFPVDTLSNHSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9G5</accession>
    <name>A0A0B1P9G5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001106">
        <property type="protein sequence ID" value="KHJ34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9G5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9G5"/>
    <dbReference type="HOGENOM" id="CLU_869307_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="36813" checksum="CF011C1A0BA6AC96" modified="2015-03-04" version="1">MDGNSQHINDVNMVKFSEQDPFIELSIEEKKELLEIMRQRKIDKQRTPLQNIQIRPQAPITRASLPKWNGKAEEFSFYMRRLMARIEREWEPYVDQGSICLDMIDSLPDHKRPRIAAWLEDNVENYCWRNLAEHFREQFEDKEERQAASKYVSRMEQSHNQLFLDFLKDSEYRMAPCREAFTPLAKSMQFKASLNSRLRRALVGLDLPPLENNSEWVKKVTKVAIELEGLKDYRPVYSEFTTTNLGVSKGGVNVPVEKQSRLDADGDVIMGESNALLSAIKSLVLNRENGVVGSKGKTKGGSVREKAVVEKPRAPVLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I9</accession>
    <name>A0A0B1P9I9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001529">
        <property type="protein sequence ID" value="KHJ33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9I9"/>
    <dbReference type="HOGENOM" id="CLU_025841_2_2_1"/>
    <dbReference type="OMA" id="AWKEEFY"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="304"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="636" mass="71201" checksum="6D12EEAC3EFCBAB1" modified="2015-03-04" version="1">MHISDKLAEAEKSGHPTFSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGGNIAQLTVEMVGVAQSYYGLETCMHLTCTDMGKEKVDNALKGAYGAGCTNILALRGDPPRQQEKWTAADGGFHYAKDLVKYIRQKYGDYFDIGVAGYPEGCDDQDDPELLLDHLKEKIDAGGTFIVTQMFYDGSNFLEWVSKVRAKGISVPIIPGIMPINTYASFIRRANHMGCKIPPKWAKALQDVKNDDAAVRSIGTVLVAELCRNILASGLIHHLHFYTMNLAQATKMVLDELNLTPSEGRPLKHPLPWRQSLSPRRREEDVRPIFWKNRNKSYIMRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLKGSSEQYRKLWGEPTSIKDIAEIFVKYLQGGVDSFPWGETPITCEADCIKSELIDLNQRGFLTINSQPAIDGVKSSDPVFGWGPPNGYVYQKAYLEVLVPNELIHEIISRVCREPDLTYHAVNMAGNLMTNTPSDGPNAVTWGVFPGKEIVQPTIVETVSFLAWKDEAYRLGLDWARCFPASSLSSQLIENVMKNWYLVNIVHNDFHETLGLYRVFEGLKVSNFDNPFDATKSLNPTTNGNSSIQNGKITNGYSIHNELKLNGCDNDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAB0</accession>
    <name>A0A0B1PAB0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000489">
        <property type="protein sequence ID" value="KHJ35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAB0"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="180" mass="19600" checksum="B94077C5F630AE1D" modified="2015-03-04" version="1">MTIANFAVVDNSPTPPKIPSHSKPTKGSGAGSGKGKIVEKNVAVATPELPKPPQTSQNTWVTVARNSQKKARVTQSNNIYTTPMIKIRPRVSTVEGASAAPTDNRLFLRLPQEHEWRKLSPAGIREAIVKKLSISPVLVGKIKPVNSGFALSPCSTEAREKNFKRRKWALFDRSKIGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAF3</accession>
    <name>A0A0B1PAF3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative peroxisomal biogenesis factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2591</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001136">
        <property type="protein sequence ID" value="KHJ33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAF3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAF3"/>
    <dbReference type="HOGENOM" id="CLU_024591_2_0_1"/>
    <dbReference type="OMA" id="CQPWNGD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="82"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="416" mass="47636" checksum="48C45CEAE15BD207" modified="2015-03-04" version="1">MTNYELTLAQQRIAARRATSSSQKALLKSTESISRLKRQSSHLSTVLSLIQDIFMKGYKNVSRREGTRPFYRVGQFDAEQLDEELLNLLKNQIINGLKYYGTHIHDEWAAEITLGIRAILFKLSVWDNNATYGASLQNLQFVDDRYRGEGIVAPSKWQKFSYGLISAGGKYAWTRWEEWILNMNVGDDSNRTVKIMSKLYKVLDMIHFLAAITSFSVFLVNGRYRTLLDRILRLRLTPQNNQVSRQVSFEYLNRQLVWHAFTEFLLFLLPLLGVNKWRKWTTRLWKRTKSVINNGIEKNSESKSGELAFLPESICAICYEEQNLSTRSGTEILLSGSSGAHSSAQKDITNPYESIPCGCIYCYFCIARQLELEEGHGWTCIRCGDEVKACRPWNADVHTESVRPSTSSKTVIFSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAH5</accession>
    <name>A0A0B1PAH5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000951">
        <property type="protein sequence ID" value="KHJ34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAH5"/>
    <dbReference type="HOGENOM" id="CLU_1526301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="20530" checksum="B8CE9C4A3CF1F504" modified="2015-03-04" version="1">MSLNTQFENQKFELKRVDNRAPKFSNSQHSNPNGQKNYKVSDSKILPLKTISKNPYVNGSRLWNKSMVPLCVRCGEVGHASPKCDSYSTSKLENWEQSYLKEMVFSIDAQMCMLQINDSQPQNEDSTYCNANNWRENDAPEVNKMSFEQFGSNNRLEEKTRVFYELSGVRYRNRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAM3</accession>
    <name>A0A0B1PAM3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000285">
        <property type="protein sequence ID" value="KHJ35737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAM3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAM3"/>
    <dbReference type="HOGENOM" id="CLU_009555_0_0_1"/>
    <dbReference type="OMA" id="VMDVPIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="577" mass="66790" checksum="9DF1CAD5BE59F900" modified="2015-03-04" version="1">MISKGLGTINGLSHIWQIDQIRENILVRLDVCSLRALRLTASNYLEVTSQRLFKQARVVFTTRSLTRPARREALSRIGHFIEHFTFVIMHSKKDFLPPLVNSETGNEIKFVYTPNTTIKSKSHRSKYASQELEDILIQQYPPIFHAATNIPAFVNLLSLIPNLQALRILCQGKFLGHNSRKNIIDYVLISLRIALERAPLYRLKKLSLCHIHPAGIRYLRHTIGYGCTPSASRRWKQIEQLEITMDTWDFHGDKSSYDHLRILNDFIRSFSPNLKKMKFIWNGQNGPCPFFANEGSHLGYLNVQPKLFRETTSTMSPLPALPSRLNMTFPKLKYFQLSNMKMTKIEVASLILQHQKTVHEFQFHNVHLADGSDWEEALMPLNLVDESNTWLLFQSGHKKNRNADFSINSQHPLSDIKFDEVVETIYPILDKIEIHKKSKIVKSSVINGEPIYRKRRRKVDRREKEKQVQPMKTKNSTLSQSNDYCQTLDPDFQGVQRNIQLENRQMELSFDPKKRISTLKKAKQAVLKQLGREFCRDSKSGRFCQENLNDEVLSSKSGMRYIGQESLTALVPLIVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS0</accession>
    <name>A0A0B1PAS0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ntf2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000869">
        <property type="protein sequence ID" value="KHJ34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAS0"/>
    <dbReference type="HOGENOM" id="CLU_017360_0_0_1"/>
    <dbReference type="OMA" id="GKTGRNW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="565" mass="63425" checksum="69FEA5CA92F72616" modified="2015-03-04" version="1">MTLQKLYEDFLMMLDASYLAEDVSLHYITTLSSIHGASAVLKNLKNPDFKIKSQEFIDVVEGPSSLALIVDTKLEFLNGGGPYLPTLDKNFITDRTVNLPIIHFISFNTALKIKKIRLNWDQGSLLKLVDIIGKTGRNWPINNGLDQIKLISSSAAPTKTMNNSTTLHAHENGMYRSNAINPTKDPHASLHLFSEDERITHGTPSIVIAARSSAKPPQRDFKELFGDLDLEPESPGNREISFRNRLKKPANSNAIAKNFGPSRLFDRDEAPTYSPEKSKNPAKFKHFEFSDGAPNEENVSSRIPSKTLKHEDHWSFDDFVTPQKIIPSKTLRANEIRHWGTSDDEVMDSPERIKKVDRPRKEIEAHFDLTEDISYQEHYAPIISRCRGQAHSNGLGLYRELFDKQDGSTMEVHETNIPSHANVKDRQKDFEAHFTMSDKSPSFTPTEKKSLDKAKAVRMMDSNWSSYDHSPTLKENIPSTAFSSHNGGSGRPLAESTNIVNNRLDVRNGIKTDGDGMGGRKGMTRSWDIGDDSNGDQDEINKPSNNRASQQLGRSQNSAGDFWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB03</accession>
    <name>A0A0B1PB03_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ob-fold nucleic acid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001025">
        <property type="protein sequence ID" value="KHJ34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB03"/>
    <dbReference type="STRING" id="52586.A0A0B1PB03"/>
    <dbReference type="HOGENOM" id="CLU_054798_0_1_1"/>
    <dbReference type="OMA" id="FCFKASP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="250" mass="28300" checksum="1C6B24345578FBBF" modified="2015-03-04" version="1">MTPTPESPRQDIYPVYCHILSPTIGRWCPLWATDINALKDVGIFCDGRKLLHYGNHPIKWVRVTGVIVAIDCGGNGSNFKRIYTLDDSSGSCIECSAPAPNAALPASKNTPLIQNQSEELKKKNLGDKVINPTRSSGQGQRGKQNKATSQSELKSEGPSVLNPIVPWDKVHVGSVVKIKGKVDVWWDHKRVEIVKLEILRCTDIEVRCWNEVIRFREDILNKSWVLTAKQERRCRKRVNRQTKNSYKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB20</accession>
    <name>A0A0B1PB20_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative abc a-pheromone efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g3075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000217">
        <property type="protein sequence ID" value="KHJ35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB20"/>
    <dbReference type="STRING" id="52586.A0A0B1PB20"/>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="TFWACLT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF288">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="44"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="261"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="694"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1268" mass="143131" checksum="E21E337990150B63" modified="2015-03-04" version="1">MSSWIVHGERIAKEIRERTFTSLLNQEICFNYLRKLESVPLLIRLDTQIRELQLSASQPSGFIAYELFSLISSIGVALYHAWQLALLFLLIFLLMAFSFWFVSRFLESINREQEAYLIKASKSACTSIREIKTIKIHNAEEYELWQYKKKLKILAKRHITQAKINALQIAMSKFVVALYFIGGFWLGLYLTTHGKNPGDIIIAFYTTLAVMQSIEIVSSQWKFVAKGIAASNAVSSLLHESQTSKEYRDSSFLPNLESSNIELRGVSFSYPGNSDRYTLINTNFFFPAGKITYIVGKSGSGKSTIGMLISGIYNATKGEILIDGNSLEKIPLKWLYENITLVDQELLLFNESIYQNIAFGRLDSVCREDVINAGKIANLEKMLINLPNGLDNLVTKCGNSLSGGQRQRVVMSRARLRDSPILILDEATSALDQTSRKQLNNQILSWRAQKTTIIITHDLSQIRDEFIYVMDKGQVVQKGRLKKLAEEKNGIFASLLQTSKQNVNEHKFKAQEELLNFTGYSSAVANSHQASNIESNKIRPDKSCESTQILFNNSSRDTLSDTVLPKKNHSRNVSVESSLYESSPELKPKSFKQSINFPNKFSKWWRKFQKIKINSYLPKYEYEMLDRNIPAVIKKSQEYLPSSNYTDGQNDFLDKPHSHPDKFGLESYTITQILRVVLKSVWPTLSRKNKLQLALGVLSSFITASVIPIFAFFISNLMNIYKSTGNQQKEGAKWITALCMLVIIDFFSTYSSYYYLERVGQVWVNELRVKCLQNILAQPQEWIDDKRHSTSLLVQSLDRNAEEMRNLISRFFCPIFTTLWLLIISILWSLSIDWRLTIVALSCVPIICTGGVVFNWVTSKYEEKCNSMAENTSTIFVEAMMNIRMIRGFSLESFFEKKYKYSLALAYITGLDRSIYTGITYGFVSDAISFMTTALVVYYGTSLIIKDLLPLLSFYQIINLIFFGLGHSLATISLIPQVNSCKIAAAKISFLANLPYKPDFELKGTQSLVPLFPVVLRDLNFTYPRSASKVLSKINLTIKKSSFIVITGPSGSGKSTIATLLLGIYAPDESLMPSLSFAGIPIDKCHVASLRSSMAFVPQNPVLFPDTIYANIAYGHPPENYFANIKAVKQAAQDAGIAEFIDSLEKGFNTLIGEGGIGISRGQAQRIMIARAFFRCPAFLIMDEPTSALDTLSASHIRATIKKMRMRHNFSSSFPAPTLVIISHCVEMMALSDYIVVLDQGKIVECGNYQELRNKKNGLLKEITTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB43</accession>
    <name>A0A0B1PB43_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001187">
        <property type="protein sequence ID" value="KHJ33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB43"/>
    <dbReference type="HOGENOM" id="CLU_071130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="36628" checksum="A6DD9D2A08D47667" modified="2015-03-04" version="1">MTDETQQSDDYYRNSQPNCVKQLPIRQDLSNLIEEQARVFNARLTEARRVIKQFTALYESISDPEIRDTREAAAAGIKDKLRIILTGVNESNSKTSQTNRKTMTLKKVSHKKPEKVIDLTTTQTRSDMGKRPTNQDSMAIETKNQTKKAVQSSWTEVIRRNPKTHTKPTQTAVTHTVANHKPVSNAITVEETKQDERLFLRVGVENAWRRMSPHYVKLSLAAKLKTASSVIEKVTVVNSGFAVTAASEAARNLLLQEARVLKDLDMKLEPASKWVSILAANVPDRLNTLNGVIPVTAKMVSEETSLKNGVHPTSVRAFVSSPERPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE4</accession>
    <name>A0A0B1PBE4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000761">
        <property type="protein sequence ID" value="KHJ34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBE4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBE4"/>
    <dbReference type="HOGENOM" id="CLU_040908_4_1_1"/>
    <dbReference type="OMA" id="SHKRGVC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080588" evidence="2">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="212"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="437" mass="46462" checksum="4E55C68963D96AA9" modified="2015-03-04" version="1">MSVTILKSLAYSVLAISLVQAVAVDHNVLRRRQTYEVQKNVVVVEKVNVFQNPDGSLATAQATPVTTSVYLASPTPINVAKPISPPVQNNVASISALHDVQPEENSDEEPEQQNGEVPDEEQDGEQPDEAPVDEPILTDPSPSPEVKSTANAKPTLAATTVSTQSQVAPKPAPSTKDIPVEPSEPKSNSRISSSTLNETMGKVAASSRAKRGIAYNDVNKLSAFASSSKVSWAYNWGSSTPNIPNNIEFVPMLWGTGAHSDKWTENANSAIASGSTHLLAFNEPDLGAQSSLTVAEAVAGYQQLMQPFAGKAKLGSPAVTNGASPMGLSYLDNFISTCTGCTIDFVAIHWYNGGNADDFKNYVTKAHAFGGGRPVWITEFEASGDAGQQQAFLNDVLPWLDSQEYVERYAYFMASDGNLISSGTTLSSLGQAFAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBI6</accession>
    <name>A0A0B1PBI6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001092">
        <property type="protein sequence ID" value="KHJ34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBI6"/>
    <dbReference type="HOGENOM" id="CLU_572663_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="477" mass="53587" checksum="8C373C0D4DF84FB7" modified="2015-03-04" version="1">MGKITERAKLKSHFENFKPAVASIKADQKAEFELLKSTRYGKPVNNYFSGWQILSIKCKTKEYSIFVTGEKDPSLALHDALQPIHPVTAIFRANQVNENANAGIEIRLSLIKKKGPKNVAGSSDVNNIDEVENIGAALLPGSVSSCSLYDKVILDSGTNIHVINNTVVQKIISSREASSKDRVYLGNDILQADAVVKAEVRLKLGYSALSSSSPRKTLIVSPKVWRKILGHPGIKAIESLPNNVDGCDFDSTEKVSTVDYEPCLLSKTKAIVSRRSEKNWEVSIINEEIHMVVVSWDIVEFSTALDGSKYLSHFYYDNEAYHHIKFINIRYSRHPYLCASIPSFQVDDSDKSNRKQFQNGKDFNIDGYPTSSPTVSRQNSEEADLNDLFVDDLDPIENANVAGANIYLGVFSSTLVLKQNESNNLRIHRDQLERPPTSWRELMRYPYKDKILAATRLELNHLMKEAMEVDNKYEGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBL8</accession>
    <name>A0A0B1PBL8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBL8"/>
    <dbReference type="HOGENOM" id="CLU_2575626_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="81" mass="9787" checksum="8E0BC96FAD48A521" modified="2015-03-04" version="1">MANIPESNYTMNRELYVKDIDIEYKELITKLRISGYIVWVMRIWKNNECHDEALIEAFQEDFAEWTSQIFDVADRLLLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBQ4</accession>
    <name>A0A0B1PBQ4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000301">
        <property type="protein sequence ID" value="KHJ35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBQ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBQ4"/>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="216" mass="23858" checksum="24926B9449CD854D" modified="2015-03-04" version="1">MIDSRTLPNTKSITEVLLGITGKDFTLIAASKAATRGASILKATDDKTRILNKNTLMAYSGEPGDTIHFAEYIQANIQLYSMKNSTDLSPAAVAHFARNELAQSLRSRKPFNVNVLLGGVDQITNKPSLYWMDYLASLAPLPYAAHGYAQYYCLSILDKHHQPDINLEAGLRLLGLCTDELKRRLPIDFKGVYVKVITKDGIKDIDFNGDEKVAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBV7</accession>
    <name>A0A0B1PBV7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="14" type="ORF">EV44_g2860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000683">
        <property type="protein sequence ID" value="KHJ34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBV7"/>
    <dbReference type="SMR" id="A0A0B1PBV7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBV7"/>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="10">
        <location>
            <begin position="282"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="540"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="13">
        <location>
            <begin position="778"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="641"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="648"/>
            <end position="654"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119789" checksum="759476BC6C06969E" modified="2015-03-04" version="1">MVKKAVDSRIPALIRNGVQEKKRSFFVVVGDRAKDVIVHLHYIMSSVDMKQNKSVLWAYKSKLIGFTSHRKKRENKIKKEVKRGIREANTEDPFELFVSLQNIRYVYYKETDKILGNTYGMCILQDFEAITPNLMARTIETVEGGGMLILLLKGMTSLKQLYTLSMDIHSRYRTEAHDDVVARFNERFILSLGKCESCLVIDDELNVLPISGGKNVVALPPPSIDEPKTESQKELENMKEALVDTQPTGALMSLAKTVDQAKALLTFVEAIADKKLRNTVTLTAARGRGKSAALGVAVAAAIAHGYSNIFITSPSPENLKTLFEFIFKGFDALNYLDHEDYSIIQSTNPAFNKAIVRVNIYRQHRQTIQYIRPQDSHVLGQAELLVIDEAAAIPLPLVRKLLGPYLVFMASTINGYEGTGRSLSLKLIKQLREQSTVASIIGVEDAELADRSTGKSAKTHIRGSGARTLREVTLSEPIRYAKGDMVEKWLNNLLCLNATLPKSKLDIGQGCPDPSQCQLLKVNRDTLFSFHDVSEMFLQQMVALYVASHYKNSPDDLQLMSDAPAHQLFVLVPPVSENSKYLPEPLCVIQVAFEGKISRQSVMNSLSRGKRAAGDLIPWIISQQFQDDEFPSLSGARIVRIATNPEYANMGYGSKALELLIDFYDRKFANLSEENGRIEEETIPRVTDLELANGSLLDDNIKVRDIKKMPPLFSKLSDRLPERLDYVGVSYGLTQQLHRFWKRSAFVPVYLRQTPNELTGEHTCVMIKPLSSSNDVSWIAAFSKDFHQRFLKLLKYHFKNFPSVLALSIGESASFGLRLDNSTQSTPFLKEDLDRLMSPFDLKRLESYANNMLDYHVILDLIPDLAMLYFNGRFETNIKLTGIQSSILLALGLQCKDLSDLEVELSLPSSQLLAMFIKIIRKISSFFASIVKNAHLDSLPERKQIGVSRADANAALEDEVIDTQFVALEQGLEDELEEGGDEVMKELREKQRELINSLPLDQYEIEESAPAWADAEKQVLNASKAGRKNPVVSVKNTKTKRKIGETAAEILQAELGEKKKHKKSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC01</accession>
    <name>A0A0B1PC01_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000637">
        <property type="protein sequence ID" value="KHJ34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC01"/>
    <dbReference type="STRING" id="52586.A0A0B1PC01"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="IDEKHEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="352" mass="38078" checksum="85ACCC3E94ABECB1" modified="2015-03-04" version="1">MKTLTCPPELLAVVEAEKRRVAQTAANIEACSVAINSVEAALATLATGSQNNFVVSLKVYLRSAIAHFLRSGTAATPPTFPPRPTGPPPAVPIIKNAAKSVLPAKFHTSQAAQNKAAGLRQNVPTQRSSKNLPNYAAPSKLNERLFLRIDKDHKWLLLAPSGVREIFCEHLNCIPYDMTYVTRTPIGFALTIKEKEIRQKLLNDSDRISSQGAKLEPASDLTTYRIATVPVALRTSSGSVTVDYTNLVAEIIRVTNVAPKMVGVHSKTRSGAPQCSWLAHFSREQAPRPGFRLFDESGVRAEAAAICAEAAEISAERLPSTDQNIVQVIIPKIEAVMTEALAEGDTIVEPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC37</accession>
    <name>A0A0B1PC37_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000830">
        <property type="protein sequence ID" value="KHJ34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC37"/>
    <dbReference type="STRING" id="52586.A0A0B1PC37"/>
    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="344" mass="38513" checksum="901B40604825BBA8" modified="2015-03-04" version="1">MSSSSTTFNKHKTTCNTLLFQKLLNLSAGVSPFTLILETLEQSGNSLIQEFGRRAKISNTKVVFVSFKTPYCKKAHLPIEISSFINARQKTICTLREEIISHLNLPKRNSVDEKCNFMLFFDSLVPLASSHSEELSSFLTSLLISSSVSLLAVYHVDIPIPCSITPYSPGPLVILTYLATAILTVSSLEQVLSRKRARDRSLPEPLFGLEEVKEGVIIGRNDSVKEKGLVVQMELRKRSGRGILENFVLIPSSSSKAIPKIIPLTEYPAYISTPTFINTENQDHSSQLDMTFNLSLSEKQKKERDEVVLPYFDAQKEGGNEGGRILYQMGTEDHEDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCA8</accession>
    <name>A0A0B1PCA8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000798">
        <property type="protein sequence ID" value="KHJ34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCA8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCA8"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="275" mass="30662" checksum="2E5A2F8FBDB5F541" modified="2015-03-04" version="1">MEVEDEFPALATPHRPILNPVAPSKRAAQNSTDSMTQSASNETYQIPAYLPKELRDIIQKRQEQERAWHFRLSICASVICNIESTLENYKGDIEKREADLIRGYLQQAIARLAASNNVPKPPPIPLKTKPLRSTIHKEGQDLERKKLSSGTSKSPTIQSILKLQKVVFEDHNKSAIEKSSWVTVARNGHKKSCIIASTPSVPSAKILDIQKNMPQASNLNQSHKKKVIVPISDSRLFVCLPINHEWRSLSPSGLREVIVKRLGVAFGLGPAVCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB6</accession>
    <name>A0A0B1PCB6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Putative actin cytoskeleton-regulatory complex protein pan1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g5755</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PCB6"/>
    <dbReference type="HOGENOM" id="CLU_001963_1_0_1"/>
    <dbReference type="OMA" id="GMPGQWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000349">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="463"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="895"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="965"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1279"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="806"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="902"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="982"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1064"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1117"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1161"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1201"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1279"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1389"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ36297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1470" mass="161593" checksum="1C9066D4D361223E" modified="2015-03-04" version="1">MFPSSNSNLGSQGSRPNPLANQSYNPYQQPLIQSQNFLNPSPLSYGQAPLQPNVTGYVQSQPNSFQSQQLHIQQTSFPTQNASNSFGIGQAPQQQVFQNNVSKVPQIPQQYQNQSQLHKAPEAPVQQSQPTGFAAMADSFRTASSNTLNRGRRAPKVQTGAKIPNIRLSFIAAQDQAKFETLFKSAVGNGQTLSGEKSRDLLLRSKLDGNTLSQIWTLADTTRSGQLHFPEFALAMYLCNLKLVGKQLPSTLPDNIKNEVSSMVDIINFGVAEEGPESAFKTNINASDFSYSLHANSISNVKQPQQNLSDPNFLSLQMPGFHGQDNIQGVLQQQQTGFQQPSQPGYSQNQSNLYPNLSTAQNNLGISTARYSGPLPPMPNSFVSNQGLSSTPTGLGGNAMPLSSQQTGMPGQWNLANTPSSGLPNIDLLQARMMPQQGRGHGAFTTSGLQGNAVIPWAITKDEKKRHDSVFKAWDSFGKGFIGGDVAIEVFGQSGLDKPDLERIWTLADHGNKGRLNMDEFAVAMHLIYRKLNGYPLPAQLPPELVPPSTRNFTESIGAVKSLLHQESDLRKNSGASLLPQKTGVSYLKNHSFRVDSSFSGSSRKDATVFKNNDDFVGYKSSARRRLGSTSAASASKPITPNDDSSIEQLRKLVHEKKLLLNAMDIKAEDNADANDVLDRRDRRDAEDLYRRIRRVQEDISSHPDAILQNIDTDSERRILKRQLQALTDRLPEIASQVRKTERSIAEARLELFRLRDVKAHPESASTVMGTGPGGIVTESDRLKARAKAMMQQRTAALTGKKIETNDDESAAQRRLEEENLKIRNEKENNERMVKDVEESVGIFSQSLHDSLDDVSQDSKNTHEKRRWEDGLGVEDEVKDFILELQRISRSALIRKNDQSKSKNSSGVDTSSGLDIKSSTTPIQATSSNQTPLQVQTANPQYKTPEDRATYIKQQAERRMAERLAALGIKAPTKPGESTQQRLEREKNERALKLRQAEEEDAKREAGLHPRLNDHEPDTPRSDSKSTVKVPPPPPSRKNVNSDSQNPKFKEQSAPVVQESDITVMKDQEDDTTHQELELAREREAAAARLKALEEQVKAGKVRKEEEKRRRKAAQSEAREKESRLKTQRAEIEAARARERELQKQLESIEADDESSDDETPEKIDSHKQIDQRSQEIETKEEFSPCPMPTPPDDNPGIPENYNTVQKSSSLDQNIVTVESSQSVQTLSAPESEPDSSSFTNAPATSSHKTPVEFETNNPFFTKSFQAAVEEIPSVQSNNPFYRLSTQDNNTPTQVQPLGNRSRVRPEDDEWSVVDSDSEDDSSDDGNAGAGNARQLASILFGAMDPPCPITAPGGVSSPSTGTLAKEVKSDSTITQDNLSSPPIDAFDIPPPPSIPPPPPMPISNVPTPPPMFDSGPPPPPPPPPQPTIGNSDTVARPAGFLGEIMKGKALKKTQTKDKSGAAVAGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB9</accession>
    <name>A0A0B1PCB9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000574">
        <property type="protein sequence ID" value="KHJ35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCB9"/>
    <dbReference type="HOGENOM" id="CLU_009630_1_1_1"/>
    <dbReference type="OMA" id="WYMLFAV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="4">
        <location>
            <begin position="148"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="726" mass="79674" checksum="3F40A3413DB147D2" modified="2015-03-04" version="1">MGGPFPSYEIRSDQYLIFYRCVPIRETPENNSIYNSSLTKIIVATREDGRCGKEFKDSICDANSGYGGCCSSFGFCGSTINHCLVERGCQSGCTSSGKVDNLATFKDKATHIPPNKPFLYSQNQKEHVNYKSNDLEEFALKYGVETQDGMCGSNNDLKICGNWFSGNCCSLYGFCGNSSSHCGAGCQSGNCDVVPIKVPDPKPAPLARNPGSFKVIGISGVAAMHAGLMPNGKVFFLDKLQNYSQIRTKDGEYAMSAEFNPKSGRPVALSYSTNAFCSGGAFLADGRVISVGGNAPLDFINPKIGDGFRAIRTLYRSSTNPYLDGRPWEEPKSRKLSTARWYPTVQTMPDGSVFVASGSLNGLYPENLKNNNPTYEMLDRKGNPWGKSYELDILVKNQPYYMYPFINVLPDSNLFIFVSKQAQVFNHKKNKVIKQLPDLPGDYRTYPNTGGSVLLPLSSANNWKAEIVICGGGTYQDITSPTDASCGRIAPLDADPKWEMESMPVGRGMIEGILLPDGTTIWLNGGSKGAQGFGLMSDPVLEALLYDPDKPVGQRFTTLASSEIPRLYHSCALLLLDGTVLVVGSNPVELPKLKPDAHDPYVTEYRVEQYTPPYLQGNKAKKRPTKVKISTKSLKADGSKFHISFYVSSGAKKLKIVLYHGGFVTHSLHMGHRMLYLDYTGFKKGWRWQKVKVRGPPNNNLAPPGPYVLYVVVDGIPSVGQFLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCC9</accession>
    <name>A0A0B1PCC9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000570">
        <property type="protein sequence ID" value="KHJ35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCC9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCC9"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="38640" checksum="55AE0E79FA30E3E6" modified="2015-03-04" version="1">MVARNGHKKARTIVPLASLSTGQSTKHKLRPSYPQHQKRDVHKKTGKENKSDNRLFVRLPADHEWRILSLAGLREVIVKRLSVSQVSIGLIKPVRSGFALSPSNNESRENLLAATGGLFMSGATLEAASNWTPILVPTVPRSITMLKGQVEVTKSMLADEIERVSTIRPAFVKPYGASNPDAPHRTWMAFFSEIPRTGFRVFDESGVTRNFKKKQQIEFCKRCNGHHNIRTCSRAPSCGNCGSTMHSQDVCMAATKCRNCGGPHRSDSHRSLARPTRTSKPTKEQLKVYRKAGDREYQAVVRANAAEARALSAEQSDGVNETPNSSQISETNAENSNIAPVTTLTGVEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD0</accession>
    <name>A0A0B1PCD0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000074">
        <property type="protein sequence ID" value="KHJ36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD0"/>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="341" mass="39553" checksum="B7042110F475A591" modified="2015-03-04" version="1">MATLNPIKTHNKSTENSLLNIKSDNSKKSEPFQFGTRLLKNEDEIFQFNAWDHVETDSDYKQYAELQYAMQREDPVSEFDKIRFNSNPAKWWNNFYKNNVGNFFKDRKWLQQEFPILSSATKADAGSITILEIGAGAGNTAFPILALNKNPNLRIHACDFSKTAVEVMRKNEAYKCDNIQADIWDVTSESLPPGLDEESVDIAILIFTFSALSPFQWEDTVRNIYKLLKPGGVVLFRDYGRGDLAQVRFKKGRYLEENFYVRGDGTRVYFFEKDELARIWTKKYIPSDLTVGNPYDVANNFETLEIGIDRRLLINRAKQLKMYRCWIQASFRKPQSNLTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ5</accession>
    <name>A0A0B1PCJ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000760">
        <property type="protein sequence ID" value="KHJ34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ5"/>
    <dbReference type="HOGENOM" id="CLU_031263_0_0_1"/>
    <dbReference type="OMA" id="HRRCDIN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="605" mass="69539" checksum="B1E8D81A596CD132" modified="2015-03-04" version="1">MHGNHEQHSVPENIKIANRNIPKRNTNLRPNFYSNDVRNHPEFHRDNVNSQYGEQNHRTLLANETSIHRGEDSLTTRDFAKAAANVERSYKQENKYEGTGDNFAFKIMIFKDLCRRMDLPPSQYMRAFPAMLNSIALSHYHSSNLADMNFEDAVHIIRTLCEGEDYSDLAQSKWNEVSLASIIEENQSKSVTECFKLLNTTLGELRTELPPELQTVAFMRSKTMLACTGVEHCRATFANPPKDLGNLISSFANSIRAKEAVEKIEKTPSTFWTDRKFHRNYNNQSGPSHDNILHRPKCYVCGKEECRSWKHNSEREKEAARNRHASNRRFLKFDRSSPRFKKRFRQWLCQYEGDADEDDYENAFAINTFPDEAIVNSNHPEDLQDEPLDSHYFTSFGKINNMEAEKTTSALIENSFLHSICPKLTERVKDYKSTDTISYDYNTFIHNLNPEPEPAAAFASMLNRYGIDIFAGLLIDTGAAKYSSVGIAQMSVLQKLSPDITIHNLDKKEEWRVYFGIVKSISKQRANIHTAIGPIVFYIFETATSFLICLADLQKCGFYLNNLTYTLNNADGSREIPVINRWGHFFLPYMPKLATYITDAIESED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD11</accession>
    <name>A0A0B1PD11_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative zz type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD11"/>
    <dbReference type="STRING" id="52586.A0A0B1PD11"/>
    <dbReference type="HOGENOM" id="CLU_007590_0_0_1"/>
    <dbReference type="OMA" id="NKHGHHP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="829" mass="93395" checksum="6848AD3FD26F99AA" modified="2015-03-04" version="1">MAYNSRVETLINVKIRYEDLRHKFKLPLRDLVPSTLQDKLCQLLEIPKGSKAVFERYSDSSKTYVVLDPNNVSSYQQLYRAARAKLRLRLRVSIINKGKEIINKSSTNDDNNSLPVISPLPGTPNRALPATKDMAPSTTKSAINSNIGSSLNDIQQSFQKLHLNDHVRNIAKADNVNETPIETKSNRLTAAINSQIAKKIEYSKIPKNTDESYIFRHNPCYSHDLSTLNKYLSGKNNRKDIEKDMTPSISADLYTLTVICNNCNSLISGEHYHCSNCDGGDFDLCQACINNGTSCYGEHHWLIKRFIKNGEPVNSITQTVTPKCHSQSKQIEKDIKNEMEIRTCNCCIAELTEDQFVTCTTCTDYDLCISCHVNLNHGHHPKHAFEPVIKDQKLNATAQILLAPGRNVEHSATCDGCDKVIYGIRHKCLDCPDWDYCSTCIVDAKTSHPRHRFVPIYEKFDPLELEQICPINGINHYGVFCDGPHCKNISSYIKGDRYKCTICDDTDFCARCEASTQNIHDPTHPLIKLKFPVEKVSVETYNDSCFNKSTSVMSDDKIVPLPTSEETSSAPSTNAEIQVQTIFDLKPLGLKENGEELTNQSSCETKDPSIVSPLFEPKIIAQFIRDSIIDGTIMLPNVSFEQTWYLRNAGKNSWPSGCYIKFVSGTNMCFVENKCLESTPEQTLTSRSIALNSEVAPGETVGFTVLLRTPCSPGNYISFWRLIAPDDRVVGPKLWCEINVEDQIPSSENKITKEKSLETSKMIFPTLQKETILTTYDQESVVQDLAEEDFEELSEENFSDEDSLDFAMTDDEYDILDASDGEYLEESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD70</accession>
    <name>A0A0B1PD70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000114">
        <property type="protein sequence ID" value="KHJ36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD70"/>
    <dbReference type="HOGENOM" id="CLU_2514316_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="85" mass="8815" checksum="600ED8C4C2018A1F" modified="2015-03-04" version="1">MVKQNDGIAIILIVFLLFMSICGIVACVLLARARANNQEDSFADTSEIVNDGVEDEAGDVGENTGEAVPEGNTQPAPPPPPPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDC6</accession>
    <name>A0A0B1PDC6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000606">
        <property type="protein sequence ID" value="KHJ34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDC6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDC6"/>
    <dbReference type="HOGENOM" id="CLU_042941_6_4_1"/>
    <dbReference type="OMA" id="NVEVFHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="214" mass="24430" checksum="94E8D7B3524F157A" modified="2015-03-04" version="1">MFKSRTEMVLTFHVAPIQELGNSRTLIQFNGSFLKENVFRLPASPEVDAAWESLGVNYRAVTVPPILAEKAGLKPSQVQINPAYGGGYPANVEGLHHLHCLNLVRQALYYNIDYYRSAGKGAFVNNDHIVRLHVSHCLDILRQQLMCSPNTALLGQIWWDRKAPKAFVDFNTEHKCRNYDTIREWAKKRQLPKNVPSDFLQPPQSVEEIYDELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDQ1</accession>
    <name>A0A0B1PDQ1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000376">
        <property type="protein sequence ID" value="KHJ35490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PDQ1"/>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="29937" checksum="C297D132CE30280A" modified="2015-03-04" version="1">MSWAGFKKNVNRATTQVMMKTGYVEKTNDRDYEVEERRYRTMETAALRLQKESKGYLDSLRAMTASQMRIAETIDAFYGDSGAKDGVSCGYKQAVEDLDAETIKALDGPYRTTVLEPISRFCAYFPDINECIKKRNNKLLDYDAMRAKVKKLVEKPDKDVTKLPRAEKEAEVAKASYEQLNEQLFTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLEPETREQYASGQLDTRVEQILEEIRGLSISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDZ0</accession>
    <name>A0A0B1PDZ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000011">
        <property type="protein sequence ID" value="KHJ36468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDZ0"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="40714" checksum="5C4D4969A8EE2AC1" modified="2015-03-04" version="1">MADSMEISTESQAPSTDTSKQPPPIPSVPPIHNPPIIIASPPPPSNLTPSNKSLAGRQILKPVTPSKRPVPEISIQNSTNNSDAANAFLPKELAEIVANRQRRERAWHARLMCCTTVISNIDSTLANITDDIEKEEAFALKAYLQLAIANFAAVDTSPAPPQIPSYSRPTKLSGHGSGKYKTTANEVTVAIPRTIKGAVTSEENTQQAHKLPKPPQLNERTWATVARNGQKKARVTLSMKTQAVPTSKATQRVTNKRNSITTAPTDQRLFVRIPQEHEWRKLSPAGIREIIVQKLSISPSLIGKIKPVHSGFALSPCSTEARQAILDAGNGLFLSGAKLEPATNWIPVIIPTVPSSIRKVQGQVEINHLMLTDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEY4</accession>
    <name>A0A0B1PEY4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EV44_g2397</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="JNVN01000376">
        <property type="protein sequence ID" value="KHJ35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEY4"/>
    <dbReference type="SMR" id="A0A0B1PEY4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEY4"/>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="301"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="456"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="376"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="501"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KHJ35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="534" mass="59971" checksum="50E9453B330D4A35" modified="2015-03-04" version="1">MDAQILNASRKYPKPSEYLFEYGTAGFRMNATLLDSIVFRVGLLAAIRSRKLGGQAIGIMITASHNPPDDNGIKLVDPRGEMLDRSWEVHATELANTKDEDVAKVYINLHEKFKINPTNRARVVYARDTRMSGIRLVKILVESLQAAEAEYTDYKLLTTPQLHYITRCINMEGTEQSYGEPSEKGYYQKLSEAFARAIKDKKVRGALTVDCANGIGGPKLAEMKKYLQKITDKLEIRITNDDVIKPEILNFECGADFVKSRQRAPKYPRIEDKERCCSFDGDADRLIYYFSDPEKGFRLLDGDKIATLCASFLCEVLKDARLSDELQIGVVQTAYANGASTRYIEQALRLPVVCTPTGVKWLHQAASKFDFGIYFEANGHGTILFSQQALKSIQSLEPQSPAHATALGILKALSDLINQTVGDAISDMLLVELILAYRAWTVKEWDVMYADLPNRLVRVDVSDRNKFKTTDAERRLIEPYGLQDDIDNLVKKYQNGRAFARPSGTENILRVYAEAATRSEADDLASKVALLCRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFJ6</accession>
    <name>A0A0B1PFJ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000432">
        <property type="protein sequence ID" value="KHJ35324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PFJ6"/>
    <dbReference type="HOGENOM" id="CLU_000327_0_0_1"/>
    <dbReference type="OMA" id="EGLMAMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="893"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1696"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2588"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2588"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2598"/>
            <end position="2622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2622" mass="298757" checksum="E9799764F17F465F" modified="2015-03-04" version="1">MAINTSGKIIKKRRVKVGTSHNKNHRWESFSTQISKLNSIDPIRRIGRYDLEIEGLSTTISYLKAGLEKWAELNMSECFTAFHRELIPMCESLPQIIHFENEIMNKFATYIEKMEKESLEPLLELVTDFAHDLGHLFEKHYSKVLGMIIFILERPQDVPIIEICFKSLTFLFKYLSKLLITDLRPTYDLMAPILGKYRQRPHIARFAAESLSFLVRKAGAPAHREKALKLIVCHSKTDLVRFKECKEYILYSNGLMTLFAEAIKGQGNNIHTSGPTIFRSMLQALDCAELSRDQFLSWKNVILGVLTSILHHTNPDSFESILEIVIELANQNWKHLDTKQNSHSLRLALLSSQMIGLCSGVRKGSRLKSWNASLTTLSNIVYLVSKNFEISSEDEISSDIWNSLILSLCITLQYAPIDSIISHIPQLLDVITKQPLQKYFLNLCFFLSDTTPERFQSVVMPYFQRFVIAHWSDNEETLSIMLHELSNSVGKEGFLLPKSWQDEIAGKLEQLQELPSLEESNQNPQDQILPKLKALLEVLDCSAVQSSIKARVSKILYRKLKSTLSKSSFTSPAEKKLIMGCGLRTFLKMASEDDILDSDLEYLLHTATSTYIRLPGFLSAFLDYKKKIKALRCKSLAQSPEGPNPNWENSIINTLIYNLSTGSHDVRLLSLLILEQICKEGKQSVPETLSIMMMIENTHVDLQTARSVSMLIRKLGALYSKIDPMSWLKNAIPRFCFGMLTVKFAQIWDDARETLKVIAESKIGEEIVFKIALSWLGIPSIKGVDSDKCAEAQGIQGLTDFECSNYSKLIYLAKDIEAKIISVQDTLQKNFIDAQDLVASEPPIARSQALRVLATAPFIAERFSRQIVPLFLSWSCKASDQSLDNEEFSISDWSRNDQKSMLRVFSAFSNSKSLYKSGEVYTSLLTLLKNGDIEIQKSALKALFTWKDPCLKPYEENLLNLLDEAKFREELGYITNGQVLVEAQHRSKLIPVLLRILYGRSMSRKSGRQGLEARRQAIFRTLSTEDTGEFINISLDSLRDIQIIREGELQEEILRNFELSSRKLVGLTHMIEGLLKELGTQVKPFIEKILNAILYCLIYSSRRLNFYHGEGVEINNATPMPTSSLKIIRQTAMKCLILLFVSSPKFDWIPYISVINNEVLKPRLDKLSDESSQGISVILRLFSTWSEDKDLAPLLGINEQIIPQIMECLSSKHSKDEVKIFILNVIKNVAIHASKDLENSKTKNSLIQSLLNSNMDILLSTINIVLKNHQDLSKELLESCIETASELAFSVSTSLQGRNLVEISTLLIEQPARRVSPKTKGRLLVMLENFIPLYNLHNDPELENKVFYVLSSLFGYFKDKESREALSRVLIVLSQKNKDFCDIASICSDLNSFVEGRLDEPDYDRRLKAFNKINDLRKMRYTVLQWTPILYNMLYYIRHDEEFGLLSSNSSDGICQLISIAGSITEQSERLAFEQLFSKVILPALFSGIRENSEIVRREYLKVMTQLVRVFPNWPEVSDMHCLLAGDNEVEESFFNNILAPGKGRQSSALSQLSAAAKKGILSSKNMSHFFIPLIEHFIFNSNEVTGTCNLSSEAMNTLGVLSASLKWPQYRALIRRLIGYIDLKPEYKKQVIRLIGKIIDPLTSVSISNINEETYVDTPTKDRSTLMITLPGQQKITEDLNSYFLAPLMKYLHDKDESTVSLRVPVAIIIVKLLKLLPQEQLNQKLPAVLTDVCHILRSKSQEARDMARETLINISIILGPQCFGFILKQLQGALSRGSQLHILSYTMHSLLVATTPTYAPGDLDYSTPKIVAIIMDDVFGATGQEKDAESYVSKMKEVKSSKSHDSMELIAKTVTIHYLRDLIQPIQALLKEKLTLRILRKIEELLHRISHGLMKNSAASSRDILIFCYQLIQDVYNSKNLDKNFKEDFRLKKYLIQKSALKSGDRDSTTIYSYKMICFAFDLLRLVLKKYDNLRISANLIDFIPLLGDAVVRPEEEIKIAAFKLLTTIVKVPLKEEYKGISLYRIALDEAVKTISASSSTVSVISQASLKLISSILRDRRDLLIKDTWIDSILLKIKADMTQTDRCNVAFNFLRAVLDSKVQTAVVYDTLDYVGSVMITNDDKETRSLSRGAYFQFLRDYPQKKSRWSKQLSFIIANLNYDREGGRLSVLEVIHLLISKSAPDFVQEVLATTFVPLVFILVNDESEKCRMSAGELLRNIFAKADPERVRTFLSLLRSWLKKSDNSSMVRLSFQVFSLYYESDNCNENDLPLVSEEISGTLKKIENKDCTWEEIYFALGLFSTLVFKFPTIMFSSKQNSLWSSLPKCLSYPHAWVKYSASKLTRIYFTDFARSNIENNLKGVPLKGSNDLTLTSNNITIFVQKIFKILDMNVLTQMLADEAVKNLVFLASVANANDLKMSFSRSVHSISHSVTSIEGNENNISTKEIDLQISEIPVLKFIFEQLNNILRRETVPPRFSALISKISALELLRNLTKTLSKDTITTYISIILMSLSNIMDPSIPTPYSTDETFRNGYENLRTSCEEIMEDLRDKVGTQIYSKTFLKVREDVKGKRMARTFKRRVEAVNMPERHEENKRKKLERKKIRRKEKSAEHKRRRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFN9</accession>
    <name>A0A0B1PFN9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000140">
        <property type="protein sequence ID" value="KHJ36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFN9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFN9"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_3_1"/>
    <dbReference type="OMA" id="LCCGAMK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="578"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="886" mass="102074" checksum="B6AF4CE4CAE03110" modified="2015-03-04" version="1">MFTIQGPVNPANLVENPSICSKYNTKQADWKKFRDIFKQKLRNDSFLQSSTYRQFQTSYSQSNFIQQESIHHISAILDNIAASLTQAIQSAALASIPLIKQGANSKPWWNPSLKSQRKDMQRKQRLCARSNQASQKSLLQLEFSEARNSYMQAIKEAKRNHWNSFLEKEDPQSIFKAMKYTKDARVGMIPPIQCRQGILHNSFPEKCKVLRDSLFPKPPTAENILQTDEEQCSETDDWPSLTQDELQQACSTKIKGKTPGPDSVNQEMIIVAYEAEPDIFFEIDLFRTKSCLVLSYIDDISLTVSSTSLKKNVRILEEEAKSLYKLASLNKIEFDLDKTELIHFTKSKEAQLINLSLPNGIIVKPKNLVRWLGIWFDNGLTFKQHLAIRIQQAKNNFYRMARLANINSGLSPHSIRQLYLACVNSICDYGSPVWWRNQASFKTDLQKLQNLATRKILGVFKTAPTKVMEIEAGIPPPNIRLDDIARRYALRLRSLPEEHPLSCLINTRYLEETVVTRPTQLEIGYAATQDFWPSNVEQIDYRKTKAWNPKPFYKVFISNKSKADEAIAHRSMIDSDRGTKTLYIYTDASGVQPSKGIGIGMVVYNMFEDRVIFENKANIGFQQVVYNGEIEAIVLALEIVSKEIQYKDYSIKIFSDNQAALQRIKIYSEKPGQEQQLRALKAANQAKSNGFLSISLIWVPGHQKIYGNEKADALARGGTNETPSSVKTSLNFIFQENRQRALEEWREDYSAYKNEALTKNRSTYAAKYEERFARTMNFPHGIKRKICSAFFQLKIEHGYFKSYLYRIKRETSDRCTCNYRAKQTPRHLLLDCKTYNSERRQLFDDLNVQRPTMALLLHTRKGIIATLKFITKTNIATRDWYEDIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFT6</accession>
    <name>A0A0B1PFT6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative c2h2 finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000124">
        <property type="protein sequence ID" value="KHJ36160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFT6"/>
    <dbReference type="STRING" id="52586.A0A0B1PFT6"/>
    <dbReference type="HOGENOM" id="CLU_067237_2_0_1"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="235" mass="27064" checksum="A4D1F8E3216F4FB1" modified="2015-03-04" version="1">MSQSKKTASSASDTDFRKKYDRAEYLARALEREAKEKEEGKARYEAKLAGKKYYAPLTGNETLTQARASRLDVASNVGKVVLMPAGSAMGKRGKGAGFYCKECDLTFKDNLQWIEHENSIQHLRAIGQTAEVKRATVEEVHERITQLWDAHLEDLRGEAKSLMERIEIRKEDDEKEREERRKKRRELVERKRIEKKNEIKVKTEYGEDLRIEGEHDEDDIIAMVGISGFGSSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG20</accession>
    <name>A0A0B1PG20_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000356">
        <property type="protein sequence ID" value="KHJ35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG20"/>
    <dbReference type="STRING" id="52586.A0A0B1PG20"/>
    <dbReference type="HOGENOM" id="CLU_009919_1_1_1"/>
    <dbReference type="OMA" id="AECGWED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="114"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="794" mass="90378" checksum="E184E315BAF75BC2" modified="2015-03-04" version="1">MNRILNRRDKDGNIQRKEKSREKKIRPLSGDSLWWVFRTSPHKKLDQEHQNIVSEIKQKLLNAGYPSPEDDQVEFALGSDYANKDPGKAYEILALFQESVEGLIRPCDPNVQLEGAINRTNVTCYVDSVLFAMFAGFQSYDQIFFGAFENDSQRILSRILLLYANMLRAGMLIHTDLTKNLQDALAACGWQNSPNEQQDASEFYGFIAQILNIPLLSMKSKIFHHATPDERHDYRIVEEQVLNVSIPDTDDCQPVPLEKCLEGYLNNKVEITRSVPRIYPFSSVRTDIDKELLCRWDTSRSTPSLPISGRPPETSNNNSLKRSQTMKEFQNSNKMYRDRVKLKKFQSTRDLSCKDVRILAWQFFNILRPSPISFKYSSKNPSNSVPILIGDIAWHKKNKTSTTIIEGISERGNTAPALVICLKRYGFKDGQPYRKNTPIDIPEEIFLPHLIDDESAEEYDQTQSFKLVLKAVVCHRGKSLNEGHYITLVRRAASISNGDSNSSQKLSDASQPPHYSKDQWCKFDDLSNPRVTKIDFIEAILAEMPYLLFYQIQPQFQESSVTSDCADSDQDPPSYDSGIALTLTASYPSQSSEMRNQSGNKNQYVAPQFSGDLGYGELPDSNGSSSLKEDLDSFKLDDSINNLCFSTQIPRLKTSNLTPPANEEITKTRISKAASLFTKGSLKSRSSSQSGESRITATILRLNLMRSREQLRKPEVCKERQNNDESFESQVPIFNVDDNVNPLSETHEFFKRKKDQKRSKSLVHGIKKDLDSYAVESLEEKSKLKDTERECKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG81</accession>
    <name>A0A0B1PG81_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Csep0475 effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000217">
        <property type="protein sequence ID" value="KHJ35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG81"/>
    <dbReference type="HOGENOM" id="CLU_1679256_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080690" description="Csep0475 effector protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17706" checksum="6B32D39E24B86896" modified="2015-03-04" version="1">MYFARISIAILICGAMALPTQLKNSDLSLEAANGNAEKRDFNSTTELISKVKEHSVATNPSANQTDTITSDSTTTMVGEINRESKLASRAIKLTKNLFNMRSLPEKSPPYSTFSITKVMKRVRFTRKRANGQNHISNNQHVQRIPKRRNMGWILQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH55</accession>
    <name>A0A0B1PH55_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000235">
        <property type="protein sequence ID" value="KHJ35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH55"/>
    <dbReference type="STRING" id="52586.A0A0B1PH55"/>
    <dbReference type="HOGENOM" id="CLU_324443_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="227"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="890" mass="103001" checksum="A2D9A3FC0AEA2FF3" modified="2015-03-04" version="1">MLNNYNTIHSTAIALNIFHNVYLDIDKKMRERKDRTETLSALRRNPENCSLRKVSDDIAKIRRLRKNENRRKDKRKLYTAQDWAAPAPANLVAKLEIPKCKSKYQSYFEFADNPDKKEKRLEFKVTNNIGPPPGYVFVPIGDPTLSNACKELSREMGAMIFIVSTCKNDHSKVSEHVHRVGFHFKETVLNAVLRTLGERKLHHSSSKVLIEPIPETQEEINKQADAAIRDLFPKIPNTDRQLVIEHAFKKGALFQGEPTVGTQSNIPLSRRVQLAVLAHIRHTHTRYDKLLRETSWLNARKVVEPVCLDIILKWRGNEENGRDQMDEILREVVIITDSESDYEDDQTDSKDSSDEEHAVISCPPSEINQQSSLRHIPKLLVPACDKELGGRPPENFPGRIQSLNPNRKCNTRKKQARRGFKRYQAAWEQALSRQQAPLNPANLGPTPENLSQNRDYLHNERPYLGFSNYESSQLKSVYQSPHYHTDFRQQKIDINRMPLLRSRSFHHDNYSEVPICRSENIDSYRSHVPIYNPNSSHRTDPVICSGQRHISPLAISRHCLQKVSVESIETASNDYLLPRIEGRVFDRFNYTPYFSPPRSNGLRYHKVESIGVASNNASSSHVEERVSDRFNYTQNSHSQWSNNLRHQDIGSIEVTSNEVIPSRTERHVSDRFNYTRYPQSMWSDEFRQNIVESIETASHEIMQPHIEKRVPNRLSYTQNKCPQRSDGSRNHELERHQVIIIDDEDNHRVGDHCMARYPGSNSSRRYPQDINFYSDQSTVNRPTKNFSVQPRDFKSRKLMDSLRLDQIPSTNSRPIFPDPAFVEEPPKSSSHSAMRLASQASYFEREKVKTIPKSQKEIVDLTLQGSSPIIDEYPYRQANEYFHSKSFSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHR0</accession>
    <name>A0A0B1PHR0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01000072">
        <property type="protein sequence ID" value="KHJ36321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHR0"/>
    <dbReference type="STRING" id="52586.A0A0B1PHR0"/>
    <dbReference type="HOGENOM" id="CLU_022045_1_1_1"/>
    <dbReference type="OMA" id="YHSTDFD"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="57710" checksum="FCFB7926F6ED0267" modified="2015-03-04" version="1">MEKSIPQLKPSITQCAIVATAFKLLLFPAYKSTDFEVHRNWLAITNSLPVYQWYRDNTSQWTLDYPPFFAYFEWFLSHFARIVDPEITKVENLGYDSWQAIYFQRATVIISELVLLLALSFFVQSAPAASQKASHAAAILLLLSPGLLVIDHIHFQYNGFLYGVLLLSLTLARENSTILHSGLVFAVLLCLKHIYLYLAPAYFIYILRKYCLYSDCILRVRITNCFKIGIGLLVIFSIAFGPFAYWGQISQLKSRLFPFSRGLCHSYWAPNFWAIYSVTDRVLISLSPYVGLTVNQTALNSLTRGLVGDTSFAILPEVTPKTTFILTILSQILPLIKLFLNPEWDKFIGAVTFCGYSSFIFGWHVHEKAILLIILPFSLIATKDRRFLNAFRPLAVSGYISLFPLLFTAAEFPIKALYTLFWTMLFLVTYDRVTPPSNNSRVFLLDRLTLLYILFSIPLVIYCNLLHQKIWQGKLQFLPLMLMSSYSAVGVVSSWLGFLVVFFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHS0</accession>
    <name>A0A0B1PHS0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000068">
        <property type="protein sequence ID" value="KHJ36331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHS0"/>
    <dbReference type="HOGENOM" id="CLU_008913_0_1_1"/>
    <dbReference type="OMA" id="AKIYAWQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="605" mass="68025" checksum="4331C000763BDDA6" modified="2015-03-04" version="1">MALEKRTLNCSYSKSESSFPSPSDCNMVSTFIHNEAALQSDMSTNKCPTGVFAASSRQMNQTNFNGTLKLRSYEKGQDKFKKDSEVFKKYNVATSKEEFDALPLNIQRRYLSTLERLKYVQSSQSRAVGNSHILDTFQNEDRFPKFNKTCTDQSAIYDQLSNAKPLYSCRKVPSLAERRGILLNHLNPKCIYTLEKLHEHSAQISTSSLLGSESPRRERSNSKTHNKDIRYRRSIILDTTGKVIERKSPIITSHHLSGEIYTPLTGDSMLSSHLGSVINVNFQSGLNNTNRKNSSVPDAYASLDWVEDDKDLNLDFSLNEYHEDVSLRSPNYSYKMKPSLRQGIPGNHPRTIMTPSPLSPKFKYLHPTDLISRSRADSLANSIKMTKTSISMTHNNALTAQGSIKSFKDKSGQEKSHTLVNTKLVQPTNSPKSIPISKKPENQIPTPNISFSTNNVKPQSSGATSDKGPNKQKYAINEKSDVQKRRSYTISSTRLPSFSIDSSHPGTSRPIIVKKIDSPLSSGNNQMTLRMTLTRPDLRADEAKIYAWQNSKFPHQNQYPVGEFSNKFEGKGPFGGPDGWILEEKEGNMVKKLWNKVTHHKSPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXF1</accession>
    <name>A0A0B1NXF1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003284">
        <property type="protein sequence ID" value="KHJ31072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXF1"/>
    <dbReference type="STRING" id="52586.A0A0B1NXF1"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39282" checksum="25A968127CB56133" modified="2015-03-04" version="1">MGISVGSIVMLNLPLHRAPESGNHWFNTYHKHHTKNLGLSKSAYDPCLLIRNDDEYFGIIGMQIDDTFGLTNTKFAELEEEKIKEANIKYKKRGILTVDKPLKFNGGLITLMKNGNVSLTQESYCKNLKTVNIKEVVTKTSSRGVVRSNLTPKDQYVAQRAAGSYIGTMCQPEVCAALSLAAQAINPNMDDAKALNKALQWQIENPKRGLTFINIEEDFEVLVFVASSFANNKDYTSQLGTIIAIKDKTGHINIIHYNSIKAKRVVRSVLNAELQGLPLGFDMGACIKKTYEKIFKKNIPLVVYTDSKSLYDCVIRLGMTLDKRMMIDVMVIRDAYEERELKKKRVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXX2</accession>
    <name>A0A0B1NXX2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003639">
        <property type="protein sequence ID" value="KHJ30783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXX2"/>
    <dbReference type="STRING" id="52586.A0A0B1NXX2"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="46156" checksum="A4E578E0CEA6D8EE" modified="2015-03-04" version="1">MAKTIQAYLRLAISEFAAVDTIPDVPKFFPTETILKSNSTSKANLPRKPPVTSDPLPSTTKNIENCWASVARNGHKKSRTIKKSVLQTTQAKKQNTQTSTGSVKKSSSGPKEITTCPQDKRLFLRLTNDHEWRKLSPAGIREIVVKKLSISPASISIIKPVRSGFALSLYKDETRQELLKAAIRLSPFDAKLEAASNWTPVMVLTVPKTINTLEGKIEVTKDMLANEIERVSLVRPAFLKMFGRNIPDAPHRTWMAYFSKAPRPGFRVFDESGIVKKFKKRQPLDFCKRCNGHHSPKNCSRAPSCGNCGSNMHTEDLCMASTKCKNCGGPHRSDSRKCLARPTRAGKPTKEQLKIFRQAGDREYQAIVRAKIAEERAATIESEMDIVTNSQSENTATENSHASSVESSTEDARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY87</accession>
    <name>A0A0B1NY87_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003438">
        <property type="protein sequence ID" value="KHJ30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY87"/>
    <dbReference type="STRING" id="52586.A0A0B1NY87"/>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="567" mass="61984" checksum="99761D78466B496F" modified="2015-03-04" version="1">MSTLFEQPRNAGTLFLGGTKISGSDIRDQNVLATQAIYNVVKSSFGPSGLDKMMVDDIGDVTVTNDGATILSLLDIEHPAGKILVDLAQQQDKEVGDGTTSVVIIAAELLRRGTELMKNRIHPTTIITGYRLALREAVKYMHENISIKIDNLSRESLVNIAKTSMSSKVIGSDSDFFSDIVVDAIQAVKSTNNRQEIKYPVKAVNILKAHGKGCRESILVKGYAINCTVASQAMKTRVTDAKIAILDMNLQKERMKLGVHITVNDPQKLEEIRKREAGIVMDRVKMILKSGANVIFTTKGIDDLVLKQFIEEGAMAVRRCKKEDLRRIAKATGATLISSLSDLNGDEKFESSALGHAEEVVQERISDDECILIKGTKAHSSASIILRGPNDYQLDEMERSIHDSLCAVRRTLESGSIVPGGGAVETALHIYLEEFAGTVGSREQLAIGEFAQALLSIPKTLAVNAALDASELIAQLRSRHALSQRIQEGEANEDEKNIAKRKNFKNYGLDLTNGKVVDEIKIGVLEPSMSKIKQLKSAVEACIAIMRIDTMIKLDPEQRAEDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYH4</accession>
    <name>A0A0B1NYH4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005226">
        <property type="protein sequence ID" value="KHJ30085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYH4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYH4"/>
    <dbReference type="HOGENOM" id="CLU_030366_0_0_1"/>
    <dbReference type="OMA" id="YTIAGAH"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="378" mass="40933" checksum="5A1C9A615BCD2906" modified="2015-03-04" version="1">MSLASKHSITNTLIASLENKDRNSSPDNTEASLLGALASSSQDVMERTMSSAYASQPGSHSSYPSAPVQSEAQSQENLSAQPSTQSSTAQPYTQSPGVKSNTGSPPEYGVFPTSASSTNFPDQISRQSHPASNHSGSSGGMPPATNPSIAASSPTYQTHAGQYSPYPPQQDIPQTYNSHPHNPMYSHPRPDWAGYANHPQHPMQSGYTIAGAHSTPPSAPAGVRPGQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGFNGCEKAYGTLNHLNAHVTMQAHGSKRTPEEFKEIRKEWKARKKEEENQRKVGDERKPDGTPPTGFPPNARSVQLPPISYQTGAQIPSPYQNTPQEFATSQQPLTYSGYPTAPYGNGTPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYP1</accession>
    <name>A0A0B1NYP1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002829">
        <property type="protein sequence ID" value="KHJ31512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYP1"/>
    <dbReference type="STRING" id="52586.A0A0B1NYP1"/>
    <dbReference type="HOGENOM" id="CLU_011154_3_1_1"/>
    <dbReference type="OMA" id="WSKGAKQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="466" mass="51385" checksum="BBDC9FCC77A23D8B" modified="2015-03-04" version="1">MDAPLLGSDMAQSDKHYKKTQAPPLKRKDTIEIDNTIIHPGSVKINVEGAFIVDEDSAAKDGNHLTVTANGASHSTKDIRLPNHTAVVSHIAVDIGGSLAKLVYFSRELHSQDPGGRLNFKNYETEYVDDCVEFMKQLKAKQQMLNGSQPGELCVMATGGGAYKFYDKIKEALGVDVLREDEMECLIIGLDFFITEIPREVFTYSESDLISFEEPRSNVYPYLLVNIGSGVSMIKVSGPRSYERVGGTSLGGGTLWGLLSLLTGARSFDEMLGMAERGDNTKVDMLVGDIYGTDYGKIGLKSSTIASSFGKVFKMKREAEREAEDSGGLNNRDSRSGIYSISSSETEDLECSPFSAADVSRSLLYAISNNIGQIAYLQSEKHSLSTIYFGGSFIRGHRQTMNTLSYAIKFWSNGQKKAYFVRHEGYLGAVGAFLKRKPLNWGRRHSFEDSLVESFEDRAFNLGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ34</accession>
    <name>A0A0B1NZ34_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g4853</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003091">
        <property type="protein sequence ID" value="KHJ31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ34"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ34"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="214"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="411"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="578" mass="63851" checksum="7A88015E44F6EAD4" modified="2015-03-04" version="1">MRGRDVQYGFFDNMAGWPSNPISSEGVPDKSTKSQGDDQSSTTNISWPTPLAPSEDNGWSSFGAPINAQSAWPSSAAVMKGTENVAWPSAATSAKESAWPNSLVSTEVKSSLKQEKPSAKQTNFEPVTKETQYISPKPPIAPESSVNQMKNSTSIENEENEVVVRLSDIQADESSPLHSASSFEDIGIKPDILKGIYAMNFKKPSRIQEKALPLLLKNPPTNMIAQSQSGTGKTAAFLINILSRIDYSFHKSPQALILAPSRELARQLENVIKKIGSFVDNLTVQAAVPGVVSRNTAVEAIVVIGTPGTVLDLLRRRQINTQKLKILCLDEADNMLDMQGLGDQCLRVKMMLNSLDQILLFSATFPDDVLEYARRFSPKAVELTLPKDDLTVSSISQMFIDCPSDNGKYEILAQLYGLMTIGSSIIFVKRRETADRISDRLISDGHQVVSVHGAYDGHDRDRILQDFRLGKAKVLITTNVLARGIDVSTVSMVINYDIPMKGRFNEIPDAETYLHRIGRTGRFGRSGVSISFVFDSRSFQCLKEITDVYKIDLVRLDHEDWDEAEATIQRVIKTSRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG7</accession>
    <name>A0A0B1NZG7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005281">
        <property type="protein sequence ID" value="KHJ30076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZG7"/>
    <dbReference type="HOGENOM" id="CLU_036019_0_2_1"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120112">
        <property type="term" value="P:UDP-glucose transmembrane transport into endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="427" mass="47044" checksum="0E5E3A538C3ACA0E" modified="2015-03-04" version="1">MASRKIENLKKKSSTSSLTPSSHSSSISVTNNHGSPSLKSAAVKNRRSPRPSKNTKNKQDLKESGGILHFLIVVSGIYGSFLTWALLQERLTTTPYGSITSPEFFKFPVFLNTIQSLFAAFVGYAYLRQSKGKKDGISTLPIFPNRRILVPLLLVAATSSLASPFGYASLSHIDYITFILAKSCKLLPVMFLNVTLFQKRYPLYKYLVIFAVTAGVAIFTLYAASPKKTSKQSTSSERNSSWGLFLLGINLLFDGLTNTTQDYIFQTFQPYTGPQMMCANNIISTLLTLSYLSFSPYFTETGIGKSLGLKLTSGSGSEFTQALAFMARYPKVWADVLGFSICGAIGQIFIFYTLSTFSSLLLVTITLTRKMLTMILSVIWFGHNLVKAQWIGVGLVFGGIGAETIIARLEKASKAKNRKFSAKKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS1</accession>
    <name>A0A0B1NZS1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arsenite resistance protein ars2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004040">
        <property type="protein sequence ID" value="KHJ30540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZS1"/>
    <dbReference type="HOGENOM" id="CLU_014487_0_0_1"/>
    <dbReference type="OMA" id="FEDKIMQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="877" mass="100182" checksum="95109F6F4723729F" modified="2015-03-04" version="1">MDTYQSHREPLIGRSPTERTSWASREAHDAFYRNERSENPRSDNFYRGRSPGTDRRRVRDRSRSPLVIDRYEPSSTRSRDDYERKRERGTRDRGEPRRVSPAPANIDRYVPGQDSGPPQLTVNMIQDPSTLPFQVGFSYFSEWWRTNERIKEEKEAARTGKRRDTRRIETQEDRDKEKSKIQAAYDVYKQELQAKMARAFVQEHKGEQWFQERYLSEPRNFLRTQLNEFRRGNYNQWEQDLESGTFDEFTLEGIPKSESNGAGGVIEKEEGETSAANEVLGVGDLVPSRGSDIRDENAFQPTLLIKTIAPHVSRQNLEAFCKEHLGEDEGGFKWLSLSDPNPSKRYHRIGWVMLHPAPEVVPIVDRPDPKDGEGELILAPVKPQSTVEKALEAINGKVVKDEVRGDFQCHVGVHVPPAVPRKKALWDLFSAPERIEKDLGLARRLVHKYEEDYGSDFNAVLKIEERVEDLRLQGRLHLPVTTPKIKKEKTSSDFLRLDEAIDEADEPVEDTDEEEEGAVDEEIDDEDLLVKKKQLDLMVEYLRRVFSFCFFCVFESDSVHELTRKCPGGHLRRPRNTLTSAGKAAAIASALGEPFPGKKRTYSDVDDEPTTPEPDRKIQRNILPKTEQQLQRAFNWVKTFEEKITQILDPDSIDIQKLGGKPIDDAIKDELTKYVKQEDEHKFRCRVPECLKLFKEEHFWRKHVDKRHSEWLEGIKRDFELINIYVLDPAHIAPSRSDANSNGHFPPANGHLSTGTPRGFSLHNFSINNIPIQGFGQPGFPPLFPGTVQHTNIYANHSGPIRRGGRQQTVRPSPYDRRSRETGRLSPPASARRNGGRWADASGGAAVGPREAVQGRILKSYEDLDAVAGGGSGELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW6</accession>
    <name>A0A0B1NZW6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fk506-binding protein 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW6"/>
    <dbReference type="HOGENOM" id="CLU_040321_0_1_1"/>
    <dbReference type="OMA" id="PWISKAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="38631" checksum="A894993B94BFCADC" modified="2015-03-04" version="1">MLPPPGFELSSFDYTSSEIVPRISATLLQSSSLSSIALPTANAYSAGSSTISPSANGECRLLGPFAIFVQGALGILALTALVFKRWRERPQRPVKIWLFDVSKQILGSILVHLANLAMSLLSSGQLSIKVDPAIVNTKELQERLADNIDDYSPNPCSFYLLNLAIDTTIGIPILIFLLHIITKLLFHTGFGTPPESIESGNYGTPPSTYRWFKQTIIYFLGLLGMKICVLIIFLMLPWLSRVGDWALKWTEGNEIVQVMFVMLIFPLIMNATQYYIIDSFIKNKKSQEHELLLESNASEGNQFYESLHDEAADALLVDSESDDLEVKKKIVQARKKKISRLDQAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P064</accession>
    <name>A0A0B1P064_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002711">
        <property type="protein sequence ID" value="KHJ31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P064"/>
    <dbReference type="HOGENOM" id="CLU_017096_0_0_1"/>
    <dbReference type="OMA" id="GRIYWFK"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="301" mass="33276" checksum="A9144D946B140270" modified="2015-03-04" version="1">MLQARPGTSYQSTSSQYVPSQPQSPSVDTITLHHIQETSIKRLSTLDYLRKVHEGRVYWFNTLLLSKSDLHRTSKSDSRKIARRATNYLLLGLSLTNIIDLYSSNPTEYIKTFNALLSEFESFQQSHRPEGISSSSLSRGRLPHMFKRATISGSKSRRASSAADIGLPMGNEGDISSAIGNGAQLSTATPTPILFPVSESDLHPGEEYTYLLTPSLPFDPDINETFATLCDVLIECYSKLITLITSPRETGPLFAELFTKADSKVKKLILQGVMKELEDRSRNGIKNELTGIGNVISNGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P072</accession>
    <name>A0A0B1P072_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004592">
        <property type="protein sequence ID" value="KHJ30276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P072"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="29303" checksum="C5E1EA2FDDA069A9" modified="2015-03-04" version="1">MCIGVIYNIESTPLVYKNDIEKEEAYLVRNYLQQAIALLAASDNAPKSPPIPHQTKPLKKKVFTQGKDITKNKALNISLITLKSQKEFQPRKSIIENHYDVNKIQQNSWVTVTRNGHKKSRAQQSVLNPTNNTKPLQHHLIVRPPTIMRNAKNAKKSNSEKSDSRLFVRLLLEHKWRKLSPAGIREMIIKRFSISPAFIGLIKPVRIGFALSPCSIEVRKNVLEASGGLSLSGAKLEPAIQYIPLLILTVLKINTLQGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P084</accession>
    <name>A0A0B1P084_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004685">
        <property type="protein sequence ID" value="KHJ30239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1215566_0_0_1"/>
    <dbReference type="OMA" id="AQGMRRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="26208" checksum="DFE070A6FEBD3BBB" modified="2015-03-04" version="1">MNINSTVIKKNINSTRFKKSINSTSFKKNINSSGIKKNINSTGNKKDNNSTRFKKSINSTSFKKNINSSGFKKIINSTGIKKNINSTRFKKNINSTGFKKNINSTGFKKNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIQRALRRTLIQRALRRTLIQRALRRTLIQRALRRTLIQRALRRILIQRDLRSTLIQRALRRALIQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J7</accession>
    <name>A0A0B1P0J7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0707</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0J7"/>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="134" mass="14205" checksum="4D971EC947583856" modified="2015-03-04" version="1">MSGGKSGAGGKSGATKNAQTRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTKPPKTASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0M3</accession>
    <name>A0A0B1P0M3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003584">
        <property type="protein sequence ID" value="KHJ30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0M3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0M3"/>
    <dbReference type="HOGENOM" id="CLU_055871_1_0_1"/>
    <dbReference type="OMA" id="RAVWINT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="245"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="38793" checksum="8BA6C5CA26A7FB74" modified="2015-03-04" version="1">MISNLDLSNSEDVNEIYFTTFGAINGKKILRDLNDKAFLHALTGSTNTLATNNSDMRYGPNVFFGIMIDTGAAKKSTVGQCQYQAFQKISDVHLDTTTAGAAKIQFGIGNTTSIGSIIVNTPFGHVKFHVVNADTPFLLSIADMDKHGVYLNNIKNILVSPTQTFPVTRRFGHPFLLWKTHLPSTTHELGQECFLTYTELRRLHRRFGHPAAHRLQRLLERAGHNDINYGEIKRLTDFCEQCQKHGKSPGRFKFKLRDEINFNFTILVDIMFIDNSPILHIIDEATRYQAAQWLSNMTSEHVWDTLCYAWINTYLGPPDYIITDAGKNFLGKNFLKLIGLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0R1</accession>
    <name>A0A0B1P0R1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003504">
        <property type="protein sequence ID" value="KHJ30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0R1"/>
    <dbReference type="HOGENOM" id="CLU_2591561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="80" mass="9610" checksum="A293F3CB8B7A638C" modified="2015-03-04" version="1">MVQRTGLGAKAGGQYIRKFIKPMRFNQANKLHYQTQAENHYFCIYQVESKNNFKFEALQDKDYELHIQEWRQAKLIIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S3</accession>
    <name>A0A0B1P0S3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004279">
        <property type="protein sequence ID" value="KHJ30424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S3"/>
    <dbReference type="HOGENOM" id="CLU_163547_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="94" mass="10368" checksum="CF0E681A7CAAFB7D" modified="2015-03-04" version="1">MKSLSSGKVQFKTVYSNLELKPLKSKSSPSRGAGVNAQYALHVWDSPEDSHNPSFPSGSPIHPRRSQSSSFLHHFPLSTFFHEAPLTIDLGSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z1</accession>
    <name>A0A0B1P0Z1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mitochondrial 37s ribosomal protein mrps12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003924">
        <property type="protein sequence ID" value="KHJ30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Z1"/>
    <dbReference type="HOGENOM" id="CLU_104295_0_0_1"/>
    <dbReference type="OMA" id="VCIRVYT"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="18438" checksum="827E50200FBEF4F5" modified="2015-03-04" version="1">MVKLNSHALRSFQNLIRYSIPSFGKLLVSRNFSSSSILSATYNQVLRGCRKARKARKAVSPALRVAKAPNLKGVCVKVETTKPKKPNSAERKVARVRLSTGKLVTAYIPGEGHNAQQHSVVLVRGGRCQDCPGVRYHLVRGALDLGGVGNRQTSRSKYGTKKPKKASTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P112</accession>
    <name>A0A0B1P112_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002198">
        <property type="protein sequence ID" value="KHJ32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P112"/>
    <dbReference type="STRING" id="52586.A0A0B1P112"/>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="623" mass="71138" checksum="C92A669FBCEA0975" modified="2015-03-04" version="1">MSAHQAEELILNSKYQGKSLKDLPKSWKFTSSLPPDTKFPSPAESHRTPRDQIVPRHVRSALFTWVRPEEKKDPELLAISPAAFKDLGIKEGDEESVEFKETVSGNRLLGWDAEKETGGYPWAQCYGGYQFGIWAGQLGDGRVISLFELTNPRTNIRYELQLKGAGITPYSRFADGKAVLRSSIREFICSEALHALGIPTTRALSITKLPHEKVYRETIEPGAIVSRFAQSWLRIGTFDLLHSRGERNLIRILSSYIAENVFDGWESLPARNQSENGDFGAPVETGIEKNTIEGPSGLEENRFARLYREIVRRNAKTVATWQAYAFTNGVLNTDNTSIYGLSMDFGPFAFLDNFDPQYTPNHDDQLSRYSYKNQPKIIWWNLMRLGESLGEMIGIGPEIDDPIFIEKGIEQKAADNLISRARALITRAGEEYNAVFHAEYTRLMASRLGLKTSPESDFKELYSELLDTMEELELDFNQFFRKLSYLSIDDLVTESQRQSKALIFFHEEGIKGLNVSDVHARKRIAKWLDKWRQRIAEDWGPNDYDKPRQFAMRLVNPNFIPRSWILDEVIKRVTAGDKEVLSRVLNMACTPFEESWGINESEEKRWCGDVPKNMRAMHCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H6</accession>
    <name>A0A0B1P1H6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002355">
        <property type="protein sequence ID" value="KHJ32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H6"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10787" checksum="CC7001A5818C1E4F" modified="2015-03-04" version="1">MAATKCRNCGGPHRSDIRRCLARPTRSGAPTKEQMKTYRQAGEREYQAVLGAKTDEDLAASTQNEILDITSSEEPEAENNTNNSQAPLVESSTCGAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S1</accession>
    <name>A0A0B1P1S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003644">
        <property type="protein sequence ID" value="KHJ30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1S1"/>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OMA" id="SIVPWPH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058822" evidence="6">
        <location>
            <begin position="24"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="185"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="581" mass="65827" checksum="DEB9626F41543176" modified="2015-03-04" version="1">MAYLLASIWGMLIEVLLFWQAQLKQWWTLQSPVEVWYSILKDAKTFEEWEEAALQLDNLTGKDLWRQNPTSKHYDYRLIHERLRSIIIAREQCDFPQLVNLLRSGLIRNLGNISTPRIYNHAFAGTKLLIEDYITQVAQAISDVTKLPTSPEGENYETWTSVRFSSQAKLDLLHDTRQAFGRSTLILQGGAIFGLCHLGVVKALLARGLLPRIISGTATGALIAALVGTHTEDELPGLISGEKIDLTAFGTENSLDKKAEQEYRNPFMARWDTLRRSLRSFLREGYFLDVSVLEKCMRANVGDLTFEEAYYRTKRVLNITVATTTKGGVPNLLNYLTAPNVLIWSAAIASNVSSLSIYGYSPILKCKDASGTIVPWSIAADTTFRPWTHVSYTDRESPLARIAELFNVNHFIVSQARPYLVPFLRSDMHGPSPIIQRWGQTSFISNILRLIGMELDHRGHQLETLGLLPRSIRRFLVTEQIPGTALTLVPEISAGDFICLLEKPTQANLKYWILRGEKSVWPAVGALKVRCVIETELDRSYQVIRRRKAVGLRRNSNAMNRNGRIEITRERVRADSLNGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1V9</accession>
    <name>A0A0B1P1V9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003504">
        <property type="protein sequence ID" value="KHJ30866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1V9"/>
    <dbReference type="HOGENOM" id="CLU_2607807_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="79" mass="8924" checksum="3761D1BC16E143D5" modified="2015-03-04" version="1">MTASYSKLKLTSNSRLPHIAESQIQYDFPNTMKETDEAWVTVKWIGLSHHIKWDQGEILLPKMGLSSPAKAGLVFQHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P206</accession>
    <name>A0A0B1P206_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001869">
        <property type="protein sequence ID" value="KHJ32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P206"/>
    <dbReference type="STRING" id="52586.A0A0B1P206"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="26318" checksum="F81F2E2B9D5F6452" modified="2015-03-04" version="1">MRADSNLRNTQETSSLSKITERVDNTWVTVARKGKKKARIIMNTEIPVAPARKATQSLTSKDKYPTRDSPKKAVTDRRLFVQLTEEHEWRKLSPAGVREVIVKKMAISPVLFGKVKPVHSGFALSSYSEEAREKILNAGNGHFLTGAKIEPATNWTPVIVPTVPATIRKEQGEVEVSKCMLTDEIERVCSIHLAHVKLYGGNKPGPPYGTWMAFFPTAPNASFRVFDESGIARKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P273</accession>
    <name>A0A0B1P273_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001831">
        <property type="protein sequence ID" value="KHJ32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P273"/>
    <dbReference type="HOGENOM" id="CLU_1469266_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20378" checksum="A57C52CA5E2DCDF1" modified="2015-03-04" version="1">MLCRSPKNDSNKLDSCKPSPETFQSMDISSFPRYLKNPSSSTSSSLTGENQIHISSTVKNYSSLSIDELRSTTPNLSEDTLTIEEIDPKEHNDILSYVVVHPYEIEDGDSECSSISSSSSSCVASFFDVNTSCKSNDSTFIDPGNRGKTGSIHKPPHRSSRCEKKRTLSKSFGSDFDFDRKILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A0</accession>
    <name>A0A0B1P2A0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001821">
        <property type="protein sequence ID" value="KHJ32777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2A0"/>
    <dbReference type="HOGENOM" id="CLU_139293_0_0_1"/>
    <dbReference type="OMA" id="KSMGLCL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="130" mass="15623" checksum="326C9645778590AE" modified="2015-03-04" version="1">MNLPDNGTVRLAYRHLYKGLLRVVQYSKPARYFARDELRNAFRHEDISNFDSIKIARTIEFLELATKYKSIEHQIIRNLLHTKYWVKYNARYKPVSKIKNKSLQKITLHAMKHYERSIEMLNKSLNISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C1</accession>
    <name>A0A0B1P2C1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative chl4 family chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002851">
        <property type="protein sequence ID" value="KHJ31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2C1"/>
    <dbReference type="HOGENOM" id="CLU_031572_0_0_1"/>
    <dbReference type="OMA" id="HPASLRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="58706" checksum="412B6C2E71C0E497" modified="2015-03-04" version="1">MNKTRPPRISYPTTFPLPSTTLLPSSHPIVRRILNRLTRPALLTLALDWLSDINQLTTAPFLREPLDDISYDLFPPSSSLEQLRGVYNGLERQGGTKRDVIERILEGDWRHGVSLYALAMADMQFLYSHPSSQNWLAWEISPLSLSSSAMLKIERAVPSFHPSVFLRNMQLECLPDIKVHFNIDRHDKLPLLILRVWILETPYNSSFSLVHTAGNFLNNSRVFYIAFPDFSPYVFISSSKTFSKTPYSPVSKAGESRSLRKIIMDAIPKAYSKPGERYRLRNTKLSAKSLEAIIEHRGNGRMNAASAAWATYAETEGSEALKDNPLDTSFKTYPYEYDDDYDDHGGDISFNKTKSTLKVKTTNGRPRSNKIESETTLLNKKVAKVRFGRSALPDDGKGIERLYVRIEDPFPNPSTSLAGLNSRHQFNNQKTVRDINDRSANISKFQKNPNKVKERTGNETWRPEISVIFAGSHIFAGIRELVECNIIDGLRMPGWMTGEEGINEGIIRNGRFTKQAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2I6</accession>
    <name>A0A0B1P2I6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g2288</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001756">
        <property type="protein sequence ID" value="KHJ32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2I6"/>
    <dbReference type="HOGENOM" id="CLU_064328_0_0_1"/>
    <dbReference type="OMA" id="TRRGTMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="29784" checksum="CD1C695F50C4D02C" modified="2015-03-04" version="1">MSNLEKHLEQISLYAESIATLSFQTKKIFTNALLHTPDITSLIRDTESHERALFSVLSPNESGTTSKAESSAISSRRQTVFKAVRDEFTAPRACVRASRRNTVITTALGTDLKREMKKSEGIINGEVDVEVLLRGIEKLNAVYCVPGVIEQVQDLRNRFVQVSRGIPQYEGKVEKQTNELERMNRGRQTENRERDNFHENDNDNMEIHSEEDNIMDSMVTDGDIQMEEREIMELEERRRELLESIDRMDRELGRNPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2L9</accession>
    <name>A0A0B1P2L9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g2595</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003160">
        <property type="protein sequence ID" value="KHJ31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2L9"/>
    <dbReference type="MEROPS" id="S09.006"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OMA" id="MRTPQEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="19">
        <location>
            <begin position="246"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="18">
        <location>
            <begin position="704"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="922" mass="104470" checksum="4A3B894DB04796AD" modified="2015-03-04" version="1">MPGNNAKDYKYLTERDRTSEDIRSSCSTSSLLFAQTSEYTATIHNSAGNEKNRMRKPSMTSPLSPEPGAKSFRSSDERCGRDIDDFDDDDDDDCKHESTAFLMNSTKLDDRRFRRLLWSVGIFFAVAWVVTLIVFLGKHTYKNYYSASQVSEPHNNHGNGKKLMLDQVLNGDWKVVKQEISWIEGPHGEDGLLLKQASPGNHYLVVEDIRKPMKGDFNIMDTMVLMKESNFTVGDRFLTPNYVFPSKDLKKVLVATNSQQNWRHSFLAKYWIFDVESQTAEALDPAEPNKSIQLASWSPQSNAIVFTRNNNLFLRNISSSKVVQITTDGSPDLFYGVPDWVYEEEVFSGNSATWWAEDGKYIAFLRTNESLVPEFPIQYYVSKSGKAKPSPGEENYPEVREIKYPKAGAPNPIVDLQFYDIEKGEVFQVHTPGSFPPHDLLITEVVWAGSTGKVLIRESNRESDMLKILLIDVLSRTGRIVRTENLQETGQGWLEVTEQTKYLPKDPLSGRHEDGYIDTIIVNNYNHIGYFTPLDNPNPIVLTSGEWEVENAPSAVDLKNNLVYFVATKESPIQRHIYSVKLDGSELKPLTDISREGYYDASFSSGTTFALLSYNGPDIPWQRVISTNGNLAKYDNLIEDNSALSNLTKKYDLPINIYSTISIDGVDLQVVERRPPSFSEKKKYPVLFHLYGGPGSQTVTKKFSVDFQTYVAANLGYIVVTVDGRGTGFIGRKARIIVRGNLGYYEAHDQIEAAKLWASKEYVDSSRIAIWGWSYGGFMTLKTLEKDAGKTFSYGMAVAPVTNWRFYDSIYTERYMRTPINNPIGYKNSSISNVTALRQNVRFLIMHGTADDNVHLQNTLKLIDMLDLAGIENYDVQIFPDSNHAINFHNANHIIYHKLNNWLINAFNGEWCRVSNPAPKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Q3</accession>
    <name>A0A0B1P2Q3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thump domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001701">
        <property type="protein sequence ID" value="KHJ32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Q3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Q3"/>
    <dbReference type="HOGENOM" id="CLU_039352_2_0_1"/>
    <dbReference type="OMA" id="MNEKACV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="155"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="300" mass="35048" checksum="8297834BDA62700C" modified="2015-03-04" version="1">MDNSKLVRVKRDFKSSHKWRTPQKSFKTEPSGRRYIEPGDLGIWATCTRGMEGKCAEELLSLFEMYAEKFYNFSNVETMEDGENRENESKDIDIETTIQKEIASLKKSRMSQSLLFQNIHLELSCVLFMKVNTTRIDPVDFVESICKSIEGNNEEKMISRYANRLTPVSLLCKATETGLEELCGQILSRYFKVNESLSNNLNQLNEKIELKEMQRKNVEHPFTYAIRPTIRNHNTLKRDQLIKQIASYISDFHKVNLTDPDKVIIVEVYRNICGMSVVNGRDWERLKRYNISELYSSRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W5</accession>
    <name>A0A0B1P2W5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ww rsp5 wwp protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001661">
        <property type="protein sequence ID" value="KHJ33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2W5"/>
    <dbReference type="HOGENOM" id="CLU_049761_0_1_1"/>
    <dbReference type="OMA" id="DANRTHM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="33127" checksum="6F7E27AF779AC741" modified="2015-03-04" version="1">MDFSDPPPPYTPQQNYGKIKEERSEAHSPRPVSIITQAARRSMEDELRELPDGWVRQYDSESGHQFYVDTSKRPPRSIWHHPYDDDEYLSNLSSSGQRRPEALNKEIFNSLPSSSSSVSPNGLNETTKSRPGVHNFGRKLKDILTSTTHEERAEARRERDRMEMEAYRRHQKIRDKTVQASITGVPQLIRIDNVGKEIWIKAPSSNVDRNGSNSHLFGQNYRMTYMAHGTGGLYRSCNRFSGDPYVSRNAVGNSLGYNHPYDAYHRPTGSSVGGGMGLPLGLGLAGGMLFGSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3C2</accession>
    <name>A0A0B1P3C2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001831">
        <property type="protein sequence ID" value="KHJ32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3C2"/>
    <dbReference type="HOGENOM" id="CLU_1846597_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15795" checksum="AA5CEBB158500570" modified="2015-03-04" version="1">MNQITNPANYDNDSMNQDIERTVTLNEDDNSLNKLNDAEKFDGIDELAQDITVDPPHCANPPRKIVKSISTHSTNDQIMENGNDDDVDELTLLITINDGPSTYKQARLSPDREKWQSAMQAEIDELEHQNGFEQQDHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3F8</accession>
    <name>A0A0B1P3F8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003122">
        <property type="protein sequence ID" value="KHJ31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3F8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3F8"/>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="OMA" id="WAPIREP"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="164"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="377" mass="43185" checksum="3068BEF23D09B63C" modified="2015-03-04" version="1">MSGKDELNSPIPELNRNRLPTLFEVLSRRTAAPVDLFFFYVYMRDQQRSVDYLDFWLDVAQHMSLCRHYVRELRRSVLIGTPDVDKPPSRQASQILENLETRNLDTEGSSTENYDRNKDDQTSAFLRENNVDKDRRLDSQQSSANSQNNIAGQKSSNQLSRNSFGLSSSQLLKTSSGSPEHSISRADIRQSAEKILFTFLLRGAEREIFLPDAIVDEITHSIEERGRDDPEVFDAAKDYVFQAMERDAYPGFLRARALGNLVPSSLTLRLILGLFSLFAAFWAGFVLIFLDYPRLPRIWLSIPFTIGIYNLIAHQYRLDPLIALAGFSEITLMSFSRLRDVYVKRLLRKRSLTVLFITTVLDSALILLFVFVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J2</accession>
    <name>A0A0B1P3J2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g6435</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002490">
        <property type="protein sequence ID" value="KHJ31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3J2"/>
    <dbReference type="HOGENOM" id="CLU_001485_24_0_1"/>
    <dbReference type="OMA" id="YYDNVFT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="233"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="883"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="889"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="314"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="971" mass="105858" checksum="E81B2E2F529532E9" modified="2015-03-04" version="1">MATAIPSPLRPSNGPPSSALPALPTGLNKVVDASLHVEKHGGTMMSNIVKDGARTPSNLNKQTPNRVTTLPKYKMAPNTNGASRSLKKQVSITAFPHPPRGNRTISLPSSPLSGGSLTSHSKTCTQLKKAESVEISSPGNIRTKKKKLESQKHSLNYGSGLSNGNSNARSTNSLGRRTSGHLLNLPSPPQSRSSSPQSLNPNFDQNVDYERGREPAPEIVSHSTSRPTEVKGNVLVSVRVRPDIGSNIACKTEGEWMVDGRRALIACRGKEAGDYYFDNVFSYHDNNAKVYDSCAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTASSPGVIPLAITDIFSYIRETPSREFLLRVSYLEIYNEKIHDLLTPPNSNGPGNSQPEEIKLREDSKRGVYASSLKEEIVQSPTQLLRVIARGDQARRTSSTQFNARSSRSHAVVQIVVESRERTPGSAFISGHNRTSNTPGGVRVSTLSLIDLAGSERAAESKERRTEGSHINKSLLTLGTVIAKLSGNKDRDGKPTDKDGKHLPYRDSKLTRLLQGALSGNSLVSILCTIQIGAAGNTASLSTHMSETLNTLKFASRAKNNLVSHAKKAEESYGQAGDGAARVLLERYRMEILDLRSQLEAQAKSKTEDDEREREKEAEIRHDEQMLEMQLARTALKERIEHLNRLILSSKSTGVNVSGSYSSLSMNPRCSIISGNGYNSGMSTRSSITPSIIRRCSLERSSSQGSNHVTARNSGQTYSGGRVSPGSLEDEYSLGEFGDGNASLAAQNRALQADLADKTRYCQTLEKRLIQARRSSHSRASISFSTVGKNNVTGEDQNFLMVLKEKDSEIADLKARLDDKERMLAALRSSVRSRDIADRDPRIVAFPFDYSQNLGTDGTSQNPLNRSSSLSSSSPRELQSLSTSTSDSISSPVKERSKGMDDRSKIIDEMIQVVETGQLAKGIRGGIRMVSERDQNFTIKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E6</accession>
    <name>A0A0B1P4E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative trna splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002249">
        <property type="protein sequence ID" value="KHJ32200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4E6"/>
    <dbReference type="HOGENOM" id="CLU_083361_1_0_1"/>
    <dbReference type="OMA" id="HPDDQIA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000012">
        <property type="entry name" value="Probable tRNA-splicing endonuclease subunit sen-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="4">
        <location>
            <begin position="38"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="21103" checksum="23AFA1FB0DC05818" modified="2015-03-04" version="1">MSQSVEEIHSSPSALQEFLDTTNSGSSTEFQSHNLARQIRHNLEFQHAWCQLIIHEQSPITQNKLPRPMIAGLPPKRLYIHPDEQIEILKHGKEEISGHPEMEWVLPTHVTENWSLQALAEIFDAVGTVPPLSPPLLNEPKDKDVGWQWRGIHRQKRLLLATLHDDSTVVYYIVHDGIVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4F1</accession>
    <name>A0A0B1P4F1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phospholipid metabolism enzyme regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002790">
        <property type="protein sequence ID" value="KHJ31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4F1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4F1"/>
    <dbReference type="HOGENOM" id="CLU_010147_0_0_1"/>
    <dbReference type="OMA" id="QHRYHSR"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="859" mass="94048" checksum="47F11BA9EE6E8699" modified="2015-03-04" version="1">MEKPSDSILDSTHETAAPDDSSNGKTPSLLLSPTVGRQFPKEDTSATSSVSRDSSPTRRFKTHLKKADSSRSPGLSPAASFYQSKKKSSQEIRSTRSTILQPLIPTTQRALSSSSILTLPTEPISKPSLISTQRVISSTSIPSHNSSTSDFTLKTSLLQKSLAKLETKENNRWPVSQRLRTPPPTSNHNLQSARNSDSESSSQLIKMASLNDDEEKLLVDSDPEDVSSFVGMRTPARGVSGASSTLETVQESSQPSTPTSGLERDSEKKKAPIATSRTDQEYPEESTSPKTLKQISISANESGNESTGKGDVKAGTIPSNLYSAIRSSGTPSKSFKSIGIGRGKPSSEGFSQNMTVETETVSSISQISVGLGGLGIGGSLRVKPSNETIRPRKEKKKVVRKPPSLTSGAASSKADIFEAKVASAVDEATSSDSEETFVYESNPPESNERPRRFQSRTPSTTSMVSQAEQRSGIRNILDGHQIIVMKKSMKFTNSHNNPSPDHVIVDETGKGTVRSSIGAGKGTAIYHHINSRWARHAGNSHPSLFDDESTFSNVASSRFLEANSRRPSRPTSPKTSYKIVVETGKDSSSAVSGYNVDYNPSEQTPLLKSTRVIKSMHPRRQNGSILQLEQQNSRPFSSRCKSYLVLFLMLLIVLSGAVGFIYATTQPLLDVEILALNDLYASDRVLVFDLVVQAKNSNLVAVKIEYTDLVLIAQSRFSKDKEYSIKYRSLHRRQRGFLTKYFGVEYPQLGDYPAANTNLELGYINVLDIPLTFEGFPFRSIPSTATGQISIKNPGNNTIPNGSDLWHEILKHDFDLILRGRLNYTLPFNQKMKSARVEFRTLISPELVELSLPHKAYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4H4</accession>
    <name>A0A0B1P4H4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ppe family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002234">
        <property type="protein sequence ID" value="KHJ32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4H4"/>
    <dbReference type="HOGENOM" id="CLU_1338409_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058906" description="Ppe family protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21815" checksum="DD873CF531752AAA" modified="2015-03-04" version="1">MRYFEILSLLTFVNVAFAGPFSQQIRARDPSKGASASSVSSPNAIESTYSSVSSQVATKNSVLHAAGDFGQDAGIAFNANNILTSMSDQDANKNAISAQGAKTTDDQRNANTIPSILQSSSTDANGQNMAALKLRSTAGVSGSTSSNKNSKNENRKRNNQDTANERFNNRNRGGNKNNDNKDEQGASSSNQRQSGDVDKAPREKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4I1</accession>
    <name>A0A0B1P4I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4I1"/>
    <dbReference type="HOGENOM" id="CLU_450700_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="606" mass="68149" checksum="4AFEB013BE3153E5" modified="2015-03-04" version="1">MASSFKDVTDSLGSLLSLPTREGNYASILCTSTGHQGTDQELTLSPKISLKDSCHSRSDPRLSKKEFDALLGLVQCGFHNSENQQIEPHSKRRKLNKTNDFEKISQSDENFMTTQYKLVSHNSILSNLSSNDDTSRIKHNRNEKEIESVNNGECNPLTDTTQSRSLAETHASDNRISADAAASCPTSDKSASEVLPSPGENQSFYPKLISSFPMACLLEIAGTRRDNIIALIVELTTYGDYRESYPNYQIPIPYRRVFDELCSQWSQGTTKNEFRKALLAYTKEKLMAQISSEESDKNKHHSDPELFENSILESTSVDAVSRFIDEVGLIKEPSKNLLRHIFGRAREILNHLKDLNSKLQTENFKLRTKISDISDKLREIETQNQSKEADSTSYDCINPILSSNQDEIFKDLDCADLFGDAEVMAFTQAKEINNDFWVCCERSSIVEGQSLPETQDNCDLGITWMTHDTCTKCLRENNDKRFFIIREQVISVGWEKFRDIANEYAKTGKIFLPTIPGNIPSKSSSQKFSPAINPVDELVPSLSDVIPLGDSTFWDVDPAQAAAWSTQISEPALGLEPHTMERLAVELEKDNPNNEDSGLSMENRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R5</accession>
    <name>A0A0B1P4R5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002472">
        <property type="protein sequence ID" value="KHJ31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4R5"/>
    <dbReference type="HOGENOM" id="CLU_001661_0_0_1"/>
    <dbReference type="OMA" id="VLMDDYM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="264"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="465"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="608"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="744"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1091"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1295"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1472"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1509" mass="167007" checksum="BDED00748ED4F438" modified="2015-03-04" version="1">MSSNVSANEPSTQAAVETLQDGGGSIKSLDAQKKIVEESRKAGVAAFVFNPNASPEEKAAQVRASIPEGFHHEQKSKAIAVPTDIDNRIPNPDLPSTMASGLSSPMTAGPSSPITAGLSSPMTAGLSSPVSTMKDINRDKPIEKTTLDSQKEDDARWIERAGWAPRFGNLTSYSCLEENLANEQTWIEGKLDEKFFGDWYHNSAVITFACLSSWLVATLGGGFSWLLIILAICGTYYRTSIRRVRRNYRDDISRELSIQKLESDTESLEWINSFLIKFWPIFQPVFAETVINSVDQVLSTSTPAFMDSLRMKTFTLGSKPPRMEHVKTYPRAEDDIILMDWKFSFNPMDRSDMTSRQIKNQVNPKVILEIRIGKALISKGLDVIVEDMAFSGLLRFKIKLQIPFPHVEKVEVSLLEKPHIDYVCKPLGGDTLGFDINFIPGLESFILDQIHANLGPMLYAPNVFPIEVAQMLSSSPIDQAIGALAITIHGAQGLRNPDKFAGTIDPYVVVSFNCGLALGQTKVIKENANPKWNETIYLIVTNFTDNLTFQFYDYNDFRKDKEIGTATLSLDTVEEYPELENEQLEILLNGKPSGLLVADLRFFPVLEAQESSDGSKEQPIESNTGIARITVEQAKDLDGTKSLIGQLNPYAVLLLNNKEIHITRKLKRTNNPIWDNGSKEVLITDRKSARIGLMIKDDRDLATDPILGTHQLKLDDMLISMEKEQEWFNLAGAKTGRVKMKLQWKPVSMSGIGPGTGGYVSPIGVVRFHFKDARKLRNLETLGKSDPYARILVSGIEKGRTVTFKNNLNPDWDEIVYVPVHSTREKLTLEVMDEETIGHDRSLGTLSVQKSEYLSQGENSEFLVRTPEAHIGNLQKQGKGPPRGTLNYTIAFYPCLNIADPEEAEENKLKEVLEKDNFSAQSPKLANVEVTNNQENRTIHSGDKGDEQVAIIEKEKIAKICLSPEELFKYESGLIILKIIDVECSKTNVHLEAIMDDMAFPSFTSSLIRSRKSTLNEMGDCVVRELEFSKITLRIREKKKVQGGEKKDKDQTVAKLTGNSIELLKQCLNNPTILKLSSDCDEACSIKVTMKYIPLNMKLDPCESINNMGKLRVDVLDASQLPSADRNGYSDPFCRFELNGKDVFKTKVQKKTLHPAWNEFFEIDIASRTTAQFKCTVFDWDFGEKSEILGSTMINLTSLESFKAQEVNLELDGKSGSVRLRLLFKPGYVVRSRQGISHLSGTFATPGKIVTGVAGVPLKGVGFAAHGVGKGANFIRKGFKSRKKGDDDINVENADTEVAEKSDNNIGDEPTQTSNQIAGLSPNSLNPITHFRSKSFGASSIRSMALAGSETTIGTAAFTILSATGYPPSTNLMVYLKQLGPKIKTLHRTEHIKTATGDVTFDERKESFKCTCSADTQFQIQVKDRKIFGSDDDLGEGLFFIDDSGTGVEKKVKVGAGSVIIKSNFILQPELGENSPRASSSAFRKSLLGKRENGKVARDGVSTTPTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U5</accession>
    <name>A0A0B1P4U5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01002442">
        <property type="protein sequence ID" value="KHJ31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4U5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4U5"/>
    <dbReference type="HOGENOM" id="CLU_031126_0_0_1"/>
    <dbReference type="OMA" id="HRTCRIP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="243"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="371" mass="42399" checksum="C6EB8BC86F7246F8" modified="2015-03-04" version="1">MSINEEDTSNIKVVKWIVDTRTLWQTSGEFKARDEVQELRKVAARALNLLPKEEQERVLKYYHIKDAKMSLASFLLKHLVITKYLSVAWSKSFLSIDKYGKPYFFLDETQLLNLDFNVSHQAGIVTLIAAITNRNRAKVGTDIVCITERRLEDYKHIDINGFFDWLSIFDEVLADTELIDLEQGSVGLEDLNIYIEGAEMTSEGNQVLSKCERRNQKVSLPILIHGAPSVIQVDSNMIIDNKLRKFYALWCLRESYIKMTGEALSAPWLRDLEILQIKVPKQGKENINLQAGETIDTFRINFKGKESTRSHVTNVTMDLTSLGPNYLVAGAVCTANFQCISEINMGEWQILDIQKDVVEVAEENFNEANFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U7</accession>
    <name>A0A0B1P4U7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ddhd domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4U7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4U7"/>
    <dbReference type="HOGENOM" id="CLU_002680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="1">
        <location>
            <begin position="864"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123634" checksum="F2C83912E9B27CFB" modified="2015-03-04" version="1">MSNSTSHRSYRGPIPGFDNELPELKAHFFYSSPLPIDDPLSAVPNTSGAEFKSMKFPLRPFSAVDSEALENAWQKLISNYDKSFPEIGQDSTSTIHDLYSNSWGNESARNFEHMSENDETGELDEDIGTERNKDNMIHAYLADQTRHYKSFSNTKLSLKLQNSENPISCKSQALISSDQSEGFSGNDGVNKSFEQNILNSIDIQESRNSALCVNSTDFFDDTYLNGKQFNLTKDKSNELILCKNNEIESQQDNNLTFHRIHSTNLKFSRDYKGGTKEYINQISSLAHNSVLHNQIQNPNEASLTGKNCPISSSNQEGTRAPKRYDSIFPNIDEGVRVTAGTTSCAPPVYTFKSDETGTTGKPFIKLPTRPCSPIECVQNVYKDEGINIKNQMRTNNPRNFSAQKSEKFSVDEPDIGGLSKVKEKKEIPSTSEVPVGISRLHLVRLPSLLMKPIYWLPVNDMASVTRGTWFYRNTMYPVEPAVANQLEFGYRELKPWSQTWKDELESALSVGAAGEEKITYRLWPSERQKFPNKEYQQLRLKISSNPYCAVRLFHGEIAAEGIANSEVKDQNLPEPKTNFKKYPTAQIIYKDTYNAFILKPNLQPSAYYGRRPLQKISKGMTIGIPVIRGFDWRMWDKFHPTKKAASIKYESYATLSKDASLPQINNSFLTVPKSNVQTTDLVLVVHGIGQKLSERVESFNFTHAINEFRRAMNVEMCNSSVRQVLRKDGFGIMVLPVNWRTNLSFEDGGLMKDDDHDHIKMDYSLRDVTQDSLPAVRQMISDVMLDIPYYMSKHKPKMIQAVIQEANRVYRLWCKNNRGFDKEGRVHLIAHSLGSVMVLEILSKQPTLIPKLDLDGENINSDYFDFKTTNCFFAGSPAGFFLLLEQAKLSPRRGSCKPDAENFNDKIVTDEAGTFGCMALDNIYNVMHYNDPIAYRLNATVDRKYAESLKEAQLPTTSVGLFGSIGRAMRSITPGIIPTQDILEDSEEPMNPLNTAHLPLNMEMEVHDFNREKIAEKKFNLLNDNGQIDWYMNSGRGPLEIQYINMLGAHSSYWMNSDFVRLVVIECGRKPGKTNTLTSMRAVKLTQFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Z3</accession>
    <name>A0A0B1P4Z3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002626">
        <property type="protein sequence ID" value="KHJ31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Z3"/>
    <dbReference type="HOGENOM" id="CLU_1200587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="26289" checksum="CBAD14580F67AE7B" modified="2015-03-04" version="1">MNVPVGTQHSIISPSTRFEYRSQIPKLNLSSKKQFLNSSISHESKLSSGDVDSHEVRESKSQTHVARNSTEVVDSLIPVSSAKTRQIYTTQPNSFWCGRFTALHDRFHNDMLEALVIDRKTYTRFQDGTLPLLPVESTQKNSDSPETTVGLQYLNDEETRRCKKSFIHLGALCVTDEAKKSLWQFQLAYARSQGKKQLLPIGGEMEPNNNRDKETLHIEQSTRIKEILQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5C6</accession>
    <name>A0A0B1P5C6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2735</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001173">
        <property type="protein sequence ID" value="KHJ33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5C6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5C6"/>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="38101" checksum="8BE9122DECE85752" modified="2015-03-04" version="1">MTAIIRVPCSSANIGPGFDVIGLALSIWLELRLEIIPTDSFVASYNCLITYEGHGAAEVPLQANQNLITQTALYVLRCHGQRAFPIGTRVHIKNPIPLGRGLGSSGAAVVAGVALGNEVGKLGLSKARMLDYCLMIERHPDNVAAALYGGFVGTYLNDLSPEDLSRIEIPVSEVLSPNAGGVDTGIPPPVPALNIGHYMKFNWAPELKAVTIIPDFEVPTAAARRVLPSLYSRADVVFNLQRTALLPTALGRSPPDAEQIYLAMQDRIHQPYRMELIPGLPQILQDMTPKSFPGLCGICLSGAGPTILALATDNFESIADAIMNIFQINGIKCSWRLLEPAEEGMTVMHSENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5E8</accession>
    <name>A0A0B1P5E8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative dna excision repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g6281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001395">
        <property type="protein sequence ID" value="KHJ33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5E8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5E8"/>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="890"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1192" mass="135769" checksum="C3CCF722AFBE8A57" modified="2015-03-04" version="1">MGVTGLWPILEPSARPTPLPTLNRKRLAVDASIWIYQFLKAVRDKEGNALPNSHIVGFFRRICKLLYFGIKPVFVFDGGAPVLKRQTIQSRRQRREGKREDAVRTAGKLLALQIKRRAEEEEELRKRKIERNKRGLTLEEDEEQETFATDKELVYVDEMGMSLQERNEKRKFHKTDAYHLPELPNNIEGMGQPNDPRVMSAKELEEYAKQFNNGEDINLYDFSKIDFDGEFFMSLPASDRYNILNAARLRSRLRMGLSKDQLEIMFPDRMEFSRFQIDRVRERNELTQRLMNLNGMNDDLIGVGTGRIAADSSREYVLVRNEGVEGGWALGVVSADKNKDGKRSKPIDVDTLGQRKDESFDSDEEDDFEDIPVEGLNRLPKLKQCLDTNDTLDSIASEDKTEKLKISLLSETADSLFIEDNTTKHVVHYKETNESDLNQAIAMSLDQFDDFSDADEHVKRAIELSLQSDNQRLFDDKKENSDLISTLELNQKAVQAVKSINTTEGNVIARICNNRANAATFKLKAKDISSESDEEVDLLTTLTKARRLESSKKVTMPTTLSPENPPNGPLPFEKLNSDLSYSEGSSFKHKEDEKEKEELEGGFNREMENDKTPRPIPPWLEAQGDIRSDIKIQRKLDAELNEEDELRAKEDQQRFLKDKMPIFIESSDDEDDVKILDEPPLSEAMTAMDLIPSIISQKPQNFTEATPNTVSNDIKNTTISSNIDYWSESDYGDAKTALTDNLIENKKSASPEFEEVQIQTDVITEIGLASLSRTSSQIFSEETEIFPLKPLLGPANPKSPNDEYDTEIEVNSDEKEYYSDPDDEELLAQLAIEAQEHGRFASTLNNKSQLENQQEYEKELKALRFQQKKDRRDADEVSQTMTTECQALLRFFGIPYITAPMEAEAQCAELVRLSLVDGVVTDDCDIFLFGGTRVYKNMFNSNKYVECYLATDIEKELSLSRENLISMAHLLGSDYTEGLPGIGPVTALEIISEFSSISDFAAWWRTAQYSTDIEQSNFRKKFRRNQAAKLFLPTGFPSPAVSEAYWNPEVDKSREEFQWGVPDLEQLRNFLMATIGWSRERTDEVLVPVIRDMNRREAEGTQSNITQFFEGGLGVGVRGEAGGAKNIARGSKRMCAAVGKLKVKKQNNDEVLNKTFADEAREWVQREKSRKDKENEDQLISKASGKRKRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G5</accession>
    <name>A0A0B1P5G5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1624</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001145">
        <property type="protein sequence ID" value="KHJ33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G5"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="53"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="382" mass="41785" checksum="668CA8CAFE0FA57C" modified="2015-03-04" version="1">MFRLTVSFSRKCLSCRSRSLGAISSQFRRTYAIPASEKIAGFHGLKDENGLFAVSLIEGDGIGPEISQSVKDIFEAAKAPIKWEPVDVTPQIKDGKTCIPSETIRSIERNKVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCRSISGYKTPYDNVDTFLIRENTEGEYSGIEHIVVDGVVQSIKLITEKASERVLRYAFQHAERIGRPKVRVVHKATIMKMSDGLFLATAERVSKEFPNIEFDAELLDNTCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDKCSIFEAVHGSAPDIAGKALANPTALLLSSIMMLRHMELESYAQKIEKAIFKTLAEGKSLTGDLGGKAKTHEYAEAIIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5J3</accession>
    <name>A0A0B1P5J3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001955">
        <property type="protein sequence ID" value="KHJ32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5J3"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="OMA" id="STTNMSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="276" mass="29430" checksum="4BC081375FAEA4E5" modified="2015-03-04" version="1">MPAVRTKRQFTMADIAKSRARARLKKKGLAPDLIDIDTIESAVNQNHSPDIEMIDEEIDKLIAKGLESSRWATKAPTLSEKDSTPFINAGDKSKSAYRIDSPISFPTQVVQEQSCTTPASEEPAMVDLCISQASSITSTTNMSHVAPTVTENTKTLTCPPELLVVVEAEKRRVAQTAAYIEACTVAINSVEAALATLATGSQNNFVVSLKVYLRSAIAHFLRSGTAATPPTLPSRPTGPPPAVPIIKNAAKSVLPTKPHTSQAAQNKAGVTWATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P649</accession>
    <name>A0A0B1P649_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001004">
        <property type="protein sequence ID" value="KHJ34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P649"/>
    <dbReference type="STRING" id="52586.A0A0B1P649"/>
    <dbReference type="HOGENOM" id="CLU_2741933_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="71" mass="8475" checksum="79BCCF4A514D6020" modified="2015-03-04" version="1">MLKESPKLVTKLKHIDIHQHWLRQEFSRDVIKLDWISTSKMPADGLTKCLSDQKHQNFIRQLNMVDFKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P687</accession>
    <name>A0A0B1P687_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P687"/>
    <dbReference type="STRING" id="52586.A0A0B1P687"/>
    <dbReference type="HOGENOM" id="CLU_1644976_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="17791" checksum="1189652F200EAE41" modified="2015-03-04" version="1">MNWTRRSQNDEPTGCIRISVPESKSNKFPSRLRTFGEAVYVQRIRPRDQPVVCTKCHGFHTARNCARNPKCKNCSSDLHDGPCIKPIRCLNCRGPHASDDKNCPACPRRISGVFVRPTGAKLHQIRTAGGRELAKTNPQSTLDPSQLPPSSLATESLVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B0</accession>
    <name>A0A0B1P6B0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002045">
        <property type="protein sequence ID" value="KHJ32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B0"/>
    <dbReference type="HOGENOM" id="CLU_2795844_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="68" mass="7932" checksum="9334A60C9DF48123" modified="2015-03-04" version="1">MNRDSFKTLLQKLCNARGWPLPTYDSYYSNPQYFCSLIVNKRCYIASSQYSEDEAEEEAASEAYRDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F0</accession>
    <name>A0A0B1P6F0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002007">
        <property type="protein sequence ID" value="KHJ32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F0"/>
    <dbReference type="HOGENOM" id="CLU_1612038_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="165" mass="18983" checksum="12CEDBF6BC9D56D0" modified="2015-03-04" version="1">MRALHLQPELQLRQWPLILKAAINILNITSNTVLKSSYFAVFQKFPKINHLHPFGCRAFWLEPDQNKLQSKAKGGVYVGTEFSGGHIILNPDTNRTVVRRDVRLHENCFPLKTSVLTPQARNRNILQSALNGPRTQDWNKAIDKEMENMKINKVWTLVPRSEAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G1</accession>
    <name>A0A0B1P6G1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative vacuolar sorting protein 39 domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000975">
        <property type="protein sequence ID" value="KHJ34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G1"/>
    <dbReference type="HOGENOM" id="CLU_004190_1_1_1"/>
    <dbReference type="OMA" id="EEYCNQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="735"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121258" checksum="355D8211BB15DCE3" modified="2015-03-04" version="1">MMLSAYNAHPIIELKLRDKSKIESILAHGDRLMVGLNNGNLRIYRVNEPFDKSKNLPDPHKTSKSSSVFKAIDLLKEIEKFSTKAIEQLAIIKESNILISLSNACISIHDLHSFTLQEQLTKTKGVTSFATTSNIIKDAAMGIPEIISRLAVCVKRRLLVWSWHESEMEQDIIEIMLSEPIRVLQWAEATKVICGLNSGFVIVDIITKSVDDVTGYTTMGSSTVNSGGRFGSVGTASIGYMGLKGYSSKPLIAKLVDDKLLLTKDTNSLFITSEGKSLEKEQIPWQQVPEAIGYSYPYILALQSPTNGTLEVRNPETLSLLQSITLQNAKQLHLPPSTVSLAHAGKDFHVASDRCVWRMRSTDYHSQIDELTQNEEYDEAISILNMLEDALFYEKTERLREIKIQKAQQLFDKKMYQNAMDIFMAQDVQAPPERVIRLYPRVIAGDVSIFESNSPGNSAENKDHIDSGADKVESNKEENGSSEAGMAIDSVKSKVVNKIFRNHLKSASDTSSIKSFKRIDSEEVSDAASITGRQNRVKMEAKDLNNAVLALIGFLVQARNRMKAFLDTETGKIKPFECQARNSENSQLQHDIESLLSVPASDDCKDYEEKLCDVATLIDTTLFRSYLLVRPQLAGALFRIPNYCDPDVVNDNLLKSGRYNDLVDFFYGKKLHRPALELLKRFGMSTENDDVSVVLQGPRRTIGYLQNLPPEMIDLILEFAEWPLRADPELGMEIFIADTENAETLPRKTVLNFLQSIDEKLATRYLEHIISELGDLTPEFHNRLLETYLRELIGEDKDKRNTKEWKNLLIKLTKLMKTSSQYSLGKAFNLIPKDDPDFYEAEVVVLSNMGQHRKALEIYVFKTKDFKRAEEYCNNVYLSSLKKATRSNIKSGKFSTPSENENEKQINSPSIFHTLLSLYLMPPHPHLPNLPFALRLLSNHGFRLPASSTLSLIPDSVSVTSLESYFRGQIQAANSKVNESRAVAGLHKSEVVNEQARLLLGENWSISALKNEIALPGSHSPGCRNRRVIVSEDRVCPACHKRLANSVITVMPNDAVLHYGCLNKWKAVLEDFIPTSNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6S6</accession>
    <name>A0A0B1P6S6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6S6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6S6"/>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="28625" checksum="217489C036AA1288" modified="2015-03-04" version="1">MFRNNYDNDSVTFSPQGRIFQVEYASEAVKQGSVVVGIVSKTHAILVVLKRNAEELSSYQKKIIAIDEHLGIALAGLASDARVLSNFMRSQCSASRLTFGRAIPLSRIVSSISGRAQSNTQNYGRRPYGVGLLIVGVDDSGPHLFEFQPSGMTQEMIACAIGARSQMARTYLERNVERFANCSREELVKHGLQALKESLTQDKELAIENTSVGIVGIGNSLKGSKIEVFKLYDGIEVKQWIDLVSDKSNISEAVESMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T9</accession>
    <name>A0A0B1P6T9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T9"/>
    <dbReference type="HOGENOM" id="CLU_136890_0_0_1"/>
    <dbReference type="OMA" id="MASMITR"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="127" mass="14326" checksum="F0115D7E5A0C98AF" modified="2015-03-04" version="1">MRPTFLRRAAQAARDFDKNLLKKSAKKDPELWVLFGVMSGAFGLAGYYFARKPTSPVSEVKVAVAQMPWEANDDEIKADYKYRYHPGANPKLSPQEAPSALNVVIVPDVTLPKELHEKFNKWGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6U9</accession>
    <name>A0A0B1P6U9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000882">
        <property type="protein sequence ID" value="KHJ34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6U9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6U9"/>
    <dbReference type="HOGENOM" id="CLU_018542_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="515" mass="58855" checksum="194E0081C158EAF9" modified="2015-03-04" version="1">MIDYCWHGKNYHSHRSALTSPRLNPIIENVKYDDCLLRTRYSSSTLCRSAVSFQSKLRKVQSQPRIRHLSSPPPEARFEHHVSFDTFASGEPTEKNTLAFTLNVKHKGYQFKKRSRTFMVGVGENEYSDIALQWMLEELVDDGDEIICVHVIDKDSKVVSDRNMEKREYQTEAKELLQRIQVRNDDNRAIGIVLEFVAGKLHATFQRMIQLYEPAMLIVGTKGRSLGGLQGLMSNRNSFSKWCLQYSPIPVVVVRPTSKRIKKKRKRDADPARQDYIRILRESGIEGHETDTDSQCGNWEISNNPENEANAVAAALGFSGYNPFLKPTQVEEIKSLARAKPDHNVKSAHRTRPSQDSSTSDLEQTLKLSPDTQNGHIEELKLEDNTKNMAACPSTENGQVAAAIRFEKVKYNMFSPKKAYKFHMAFETLETSSESQVVSVNEQDKNETETEFEVIPGKFLLNESEIHLSEHEKKLEELEIKDFLIARENTFLAAQIARNFSMDDCIFNDDNNVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P797</accession>
    <name>A0A0B1P797_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g1289</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000812">
        <property type="protein sequence ID" value="KHJ34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P797"/>
    <dbReference type="STRING" id="52586.A0A0B1P797"/>
    <dbReference type="HOGENOM" id="CLU_044271_0_1_1"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="25686" checksum="B35A1782B8F2704F" modified="2015-03-04" version="1">MANSKYEYVKLFEQPDTLLPETWLVVRIDGKGFHKFTNRYSFEKPNDRRNLDLMNSAAKAVMSEIHDIVMAYGVSDEYSFIFHKFCELYDRRQSKLLSTVVSTFTSYYIHYWPDFFLDVALSPPLPTFDGRVVMYPNEKCLRDYLSWRQVDCHINNLYNTTFWSLIQLGGLDAKSAEKELTGTLAADKHEILFSRFKINYSKEPEIYKKGTIVIYDVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7H2</accession>
    <name>A0A0B1P7H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative csep0310 effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001766">
        <property type="protein sequence ID" value="KHJ32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7H2"/>
    <dbReference type="HOGENOM" id="CLU_2442501_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036417">
        <property type="entry name" value="TMV-like_coat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47195">
        <property type="entry name" value="TMV-like viral coat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="90" mass="10061" checksum="3DD614258D421AD8" modified="2015-03-04" version="1">MSRRGIIPVLIASSIGIINGIWVFKPALSEQQQMISSIDLRKDPVYVSNNDEETSTSSSSLTQKAQDSTTQLHNESPSIWSKIITKWNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R3</accession>
    <name>A0A0B1P7R3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001867">
        <property type="protein sequence ID" value="KHJ32704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7R3"/>
    <dbReference type="HOGENOM" id="CLU_1134267_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27805" checksum="350898D90B0B4AAF" modified="2015-03-04" version="1">MAIKTLQTPVEAHHSIGLVERYHAPLRRAYEIISQELKGMNISKDMILQMSVKASNDTAGPDGIVPTLLVFGTYPRMSELDPPAPSISQRSLAISKAMKEVRKLRALRQVTEVLRQRNGPSNVELHKLPLHSDVLVWRENLKWTGPFKLLLVEGETCKVELPSGPTSFRSTSVKPYFHEVISEYNKSNDKNINDSNSDNNDNSNKDLTNYDNDEFKNNNDNINKSLPQSSTRRNPVRSHRLPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P879</accession>
    <name>A0A0B1P879_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000859">
        <property type="protein sequence ID" value="KHJ34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P879"/>
    <dbReference type="HOGENOM" id="CLU_2706637_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="8457" checksum="072CCD506C369852" modified="2015-03-04" version="1">MDLDDETETEYEPENDDFPPLGSTISHKRNANMFTTDENQENNCTQKEDVSTQDLMLMIKARDLLNLMGPYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E8</accession>
    <name>A0A0B1P8E8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01001720">
        <property type="protein sequence ID" value="KHJ32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8E8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8E8"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000370">
        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007116">
        <property type="term" value="P:regulation of cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901901">
        <property type="term" value="P:regulation of protein localization to cell division site involved in cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="37375" checksum="678C7334E9245435" modified="2015-03-04" version="1">MAEFSDIDLESIIDRLLEVRGSRPGKQVQLLEAEIRYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQKYVYGGLGVSRPITPPRKPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K0</accession>
    <name>A0A0B1P8K0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000809">
        <property type="protein sequence ID" value="KHJ34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8K0"/>
    <dbReference type="HOGENOM" id="CLU_044092_0_0_1"/>
    <dbReference type="OMA" id="SIHMIHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="35451" checksum="A3F299BF4209720D" modified="2015-03-04" version="1">MSTISQPVASVDFLILGAGWTAGYLIPLLKSMEISYAATTTTGRDGTYKFKFEYDPNTNNQASNIDLKPYAQLPYAKTILITFPIAGELSSLWLINTYNDLHREMTSLETLWVQLGSTNIYNDVEAQELWISRKSCFDSINPRAMAEVNLLRAGGCVLNLAGLWGGQRIPMNWLPRVASTKQELGKLKSLHLIHGKDVARAIVAVHQNPHLATSQRYLITDLIIHDWWEIALGLGALSLNHPDIQERNETYAKWINGLMQEQNVKALPRTPEQLSRCLDSSDFWFTFRLMPRNIYIYKHQIARLQSHFGSADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R3</accession>
    <name>A0A0B1P8R3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative at hook domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001529">
        <property type="protein sequence ID" value="KHJ33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R3"/>
    <dbReference type="HOGENOM" id="CLU_010318_1_0_1"/>
    <dbReference type="OMA" id="DEHYNRS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="879" mass="98664" checksum="6EA4F7405E7BA10B" modified="2015-03-04" version="1">MGYVQSPDDYFSYESRLASFLKVHPVSKRRASNTSLKGPKSLKWPHKFLSASDLAKSGFYYLPSLTSPDNVVCFLCHKLLDGWEETDNPFVEHLRHSPNCGWAITTSVERSIGEWNEEQPNSTKLLEARKATFADRWPHEDKKGWKCHVKQMIEAGWSYTPTLQSDDMVTCNYCALTFDNWGKNDKPSDKHYESSPDCPFFALTNNYIKSPETKKISPKRTRASWTNRFSAQSNLSTCSNGSRETSFSAEEKDSILTMVSTSSQKMAPEKKKAQIKIRKHRLRRNEAAEVTKPEGIVGKVQDLNRGRKRISEESQISGDKKIGLPPKRRTARNRDGTAADFTKSQTTMSSQQITNSQQRIAKSTMNRSLVKATTSITDSDIEKVLEADLDRPISEDETLQNEVPRVILKSNYTVFNNEHKDIDDDALEVDTNIVEKNVKPSSRLRVTRSTSSSEQRFTHREVDEFKSQGAQNESLDFKISAELGYNLSAGYSSPLAAPATKGRASSRKATRKLAARNTRSSAMSPSSHNSSMAVNSSALEMMVEPRSSSKRKHINYQNPIKPISSSNQVENEDNDKRCDKKPSSRTLKENNPATEILKSHTFSQKLVSSSKKNEGQNSELESTENKCSLPNSTNSENRPSLDPPVGTIEIKDNKSTKHSDEKKLPNSSFLRQNVLEIPKLNSSEVERSVSQTSKSPMASTKTSISRRREATPQSSPACSDAENKPPSLKLSLSNRNITTPPKTRRVVTIDETPIRSLPSKHSTFVGLPSDQPWSAVDPEKIFLKSPTNCSTTSDVAMNQFEIVINAENNLLLTENPLEKAIQQGGLTNMEEKMTVEEWIHHNAHVAEEMLKRECERMVNKFELEGTRAIRALEGVRCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8V0</accession>
    <name>A0A0B1P8V0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative gtp-binding protein rho2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000754">
        <property type="protein sequence ID" value="KHJ34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8V0"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035840">
        <property type="term" value="C:old growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="198" mass="22027" checksum="24162FFEBF50BD15" modified="2015-03-04" version="1">MAQQPTQNVIRRKLVIIGDGACGKTSLLSVFTLGYFPTVPTVFENYVTDCRVDGKNVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSIDMPDSLENVKNKWVEEALDRCPNVPIILVGLKKDLREDPIAIEEMRKRSQNFISTREAADVSKSIGARKFLECSSLTGEGVDDVFEAATRAALLTFQKGERGNCCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P927</accession>
    <name>A0A0B1P927_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g2667</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="JNVN01001413">
        <property type="protein sequence ID" value="KHJ33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P927"/>
    <dbReference type="STRING" id="52586.A0A0B1P927"/>
    <dbReference type="HOGENOM" id="CLU_020346_3_1_1"/>
    <dbReference type="OMA" id="KPFLEVW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="129"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="490" mass="55744" checksum="2793E5A4550E7588" modified="2015-03-04" version="1">MVDYSEDANEQPQPFNANKLEPAKKRKRSRSPLVSVSTTTKPSKQTDLQTNNELKRSTSPPYRKQKRPGKRARIGDAEREQIRQRRLEREKELEAAAAAANATKGIHDAVKQHYNAVPERGRDWRKTSSRIKGLRSFNNWVKSVIIQKFSPNEDFKPSVKYNDDAFSEKSSTNTGISVLDIGCGKGGDLGKWQLAPQPVELYVGIDPADISITQAKERFRQMASRDRGSRSGRGIHGKLHQRLFYGEFYVQDCFGESIEKIPIIRKVGFDGSGRPSSFGGGGFDVVSMMFCMHYAFENEMKARLMLKNVAGALKKGGRFIGCIPNSDVLSEQVKKFNARMKTKLEKDQAVNQHDSKNNEESEGEEGEAEDTASWGNGIYKVRFPGETPEDGIFRPPYGWKYSFYLHEAVEEVPEYVVPWEMFRAIAEDFNLEMQYHKPFLDIWEAEKDDEVLGPLSERMGVRQRDRGPLLISKEEIEAASFYVAFCFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P929</accession>
    <name>A0A0B1P929_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001590">
        <property type="protein sequence ID" value="KHJ33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P929"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="17896" checksum="904B4AEF5486FD2A" modified="2015-03-04" version="1">MAFFSKAPRGSFKVFDESGVARPFKKQQPLEFCKRCNGHHPTKNCSRASSCGNCGSTNYSKDLCMAVTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQLKAYRQAGEREFQALLRVKAAEEFAATVESTNDNVISSQVTEPESNIENSLAPSVDNPTDDAMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P984</accession>
    <name>A0A0B1P984_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative rab gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P984"/>
    <dbReference type="STRING" id="52586.A0A0B1P984"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="QSTRACC"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="216" mass="23504" checksum="64815C43A9D75E9C" modified="2015-03-04" version="1">MAARAPTGARTGNRFAQFKLVLLGESAVGKSSLVLRFVKNQFDDYRESTIGAAFLTQTISLDDTTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKQWVKELQRQANDNIIIALAGNKLDIATSNPDKRAISTADAEAYAKEAGLLFFETSAKSSENVKELFTSIAKNLPLNQAGSRNPRAMGRGVELKTESPGTQTSGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D4</accession>
    <name>A0A0B1P9D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative anucleate primary sterigmata protein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P9D4"/>
    <dbReference type="HOGENOM" id="CLU_001023_0_0_1"/>
    <dbReference type="OMA" id="LHHAHRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1396"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1519" mass="172081" checksum="DFC66227D06C5BFA" modified="2015-03-04" version="1">MATLMESNLSFEASNSNRSPSEQDPFISQATNSNHHRFANFDSNIFSQSPTTSPEQAKRALEAHLAETERRIQDTSRLGTALLQQRKDLEGRLEEIGKQQDEENITPELRQKLLEIEKDYYEVGRESARAFLSKPRVLNNDIVDSSIASGIMDKRLISPSKERFESHGMGSPSKINVSNRRQRNQPINRIHDIEFATEISTSLLSQVRHLQALLAEKDDHMKNIALENSRLEVEIEGFTDRLRSLDESGERYKDENWNLETQLQEYKAKEKEAADRERRLTQNYNIIQSEKSAAQKDLDEIKSAYAKLLEEHNLALKYSDAELGSAKRNLIEIETERNSLQQKVDELLGQNRELVKAIAYQRGRLEDKNENYGVAIEDLDMKSDDLTPEHSPPPSPVKGTPRHSLLESETLKSSLHHAHRMIQNLKSNIYREKTEKLELKRLLQDTRDELEQRRGEIGQSNGKKARKLDLKDSKRQAKIGQLGGLRNSTCEVCIDESNWEDENQDERHKNINPSQEISSDALHERLLIASTDLVVSTATTPAGTSDHFETANEHEVSDAFETADESAIQKNDLHDSPDNYSEDFTETECETRDLKQRKSKRTVSGNRYSFQSTASTSDDDYDNGQQNYRVINNTQPSRLRLKVNRIVSRRSRVSSEEPHFNSSPASFANTSRDGTPQAKGQSLFAELGEIVGCDEDELIGETPNSFKSTPRSMRSNSSVRALKSRPMLPSAMFRPAMVEFGMMTEPWEPEFPIDPKTVPNIYKSKVNNINLSLNFPESFPDYVSVATQIDSLVMMTDASSQWSEDNLLDKKEMNSQPIHFPNYIDMSSQCDLDKDIMHDNFTPNPKISTSIANKSSTNYIDASSISDKVYLSVSKISSEEFTPIDSFNSNIHRPVNTQQEYSEFFPECLDFSTIQHLEIEPIEPLGFPMDFNPFSNEELENDEKIQNIEPQSLKKWTSKLVKTDRASEICNFESRVHVSTDDFDTIASSNSQLFGQDFVKSNKSYITSKKINTIDESSQTVLTADEIENMLKSIPVPVLIESQRNSSSSSRASQSLSQKISQSEILRCNDQTKVSMVMKTSESTLIDVPRAQSKATYRQNNVGAHGNQISANEKIKITPATAQNIKLSHSTSTNMGPPPLPSNYRNMPKSQSRPLTPNFHVPSSPSINDSPTPRPNQSYGSVVIQTPTRINMRSRVSSISSFASEIDTRFQMHNRVGVSTGMQSGIGSGTDPRMISAITQTMIGEYLWKYTRKTGRGVMSEKRHRRYFWVHPYTRTLYWSNRDPSLAGRAELKAKSVPIEAVRVVTDDNPMPPGLHRKSLIIITPNRAVKFTATTGQRHETWFNSLSYLLLRTEEESLEDTSGVVNGSITCEDVAEFNPSCNNHHTNRNESHAKNSHINGSRSSRLSVGNFSRLSNYWRPSREGLIGSMSSRQSKYSIDNIKSVYEASEVHDSAEDLREFLRRQDRESDKLENVRACCDGRHDVGHLHNSSRSRYTKTISTIQGSSRVEGSVRYDSRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9S6</accession>
    <name>A0A0B1P9S6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative l-fucose permease glucose galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000398">
        <property type="protein sequence ID" value="KHJ35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9S6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9S6"/>
    <dbReference type="HOGENOM" id="CLU_028452_3_1_1"/>
    <dbReference type="OMA" id="GAYFLCP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="457" mass="50015" checksum="378923A67E2A0DAD" modified="2015-03-04" version="1">MSIFKRKISISNDTVTSAAKLTLRQSLMPCFLVTTLFFLWGFAYGLLDVLNPHFQKSLHITPSMSSGLSAAYFGAYFLCPPTFSGFILRNFGFRVTFMCGLGVLSIGCLCMWPSGMKHSFGGFCGSMFVVGMGLSTLETAADPFLAICGPPRYSEIRLNLAQAVQAVGSFAAPLLASRVFFANTVDDNEGLKNVQWVYLGVSCFVVCLIFLFAIVPMPEVTDEDMGIQEIEIAKHNPGPFWKQTNLFLAVWSQFCYVGSQVVLANYFVNFCEEAGKSPSTSSNIFAAAQGLFAFNRFLAGGLMTFPAFQPRIILAIYLFLSFVFTLAAAFTNNNTSIIVLCLAICFESACFPTIFSLGLRGLGRYTKIGGSLIVAAIGGGAVLPPIAGAVATKMQRIGSKRPFHLAMIVPTIGFIVAWIYPLYANIWNRKVIDIRRETRLGIESIRGTKDLEQEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9S7</accession>
    <name>A0A0B1P9S7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mitochondrial ribosomal protein subunit s18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9S7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9S7"/>
    <dbReference type="HOGENOM" id="CLU_072439_0_0_1"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="28322" checksum="993893D48652D35F" modified="2015-03-04" version="1">MWPNRFIASRVFLKCSVKNGYLCQPRVSGFSQIVTFHHSALLSEAVNKANLDFFLNIASNQSSPSTNNTEESSGKETTMNGPRLPLLDSNKISSDGTMSPDESIHLCKDGVYKDVTWQMHIYAHRHNVHITIARPPAWRHPVTGKVYGENPPSRSVALSLCAGRLGFKHSGRKHYDSAFQLGTYVMARMQESGMNSYIERLEVYLRGFGAGREAVTRVLLGVEGKYLRNKIVKVADSTRLKIGGTRSPNPRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA02</accession>
    <name>A0A0B1PA02_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA02"/>
    <dbReference type="STRING" id="52586.A0A0B1PA02"/>
    <dbReference type="HOGENOM" id="CLU_035351_1_0_1"/>
    <dbReference type="OMA" id="PGKEFCK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="445" mass="48581" checksum="857DD6085C03374F" modified="2015-03-04" version="1">MTSTDNNDGFEPTGLTLPITTEPVDILDELSLAITNDILYGILHDLMLETHREAKTERAASAAAIVKQKALDEHPNLADEISAGIQHPKIETRTAGALYKDGAIYLTENPLKSTLQIICPKCGLPRLLHPTTGRGAKTPEPGVEYCKKRPFIDKDYYDVHGQTFVPKGPGRGRRKEDMIDPVMQQLKASLPNGSQDSDTSAQIPTQLKEPHAKCINCGSFQAASRMNKHMSKCIGGLSRESARNAKSKIFNGNDTSSQNGHTPPGSRNSTPALGAGSIKNSPGKRSAEEEPDESDEAPKRKKKRLIKRGHITKSKASQINVKKNGGQTLASNLSFENKLTDVEDDDVEGDDSRDINYGTKLTNKNKLTKSSTIKIENAVKPKPKILKRLAKSKRNSSQEQPSVEMRNSKSNSSESRNKSLTRHNRGGATPPTEESSQTMSSPNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA44</accession>
    <name>A0A0B1PA44_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000994">
        <property type="protein sequence ID" value="KHJ34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA44"/>
    <dbReference type="STRING" id="52586.A0A0B1PA44"/>
    <dbReference type="HOGENOM" id="CLU_625845_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="438" mass="49705" checksum="F5B390B49A58DDF1" modified="2015-03-04" version="1">MPKAYRVISLLSCLGKVSERILAKRLSYLVEISQLLDPTQIGGRLTKSAVDAALLLINEVETNRQIRRVTSTLFLDVKGAFDHVSRNQILDQIKKIRLPTSLISWVASFLDHRVLQLSFNGETESFKSAETGIPQGSPISPMLFLIYISDLFITQDVRCISYMDDIAISTKSTSLRKNTKTLEREVAKIYAKGSQNAIQFDLLKTELMHFTRSKKADTWHVRLPDDVVIAPTQLVRWLGIWFDPSLKFRSHINIRAAQALQTFYRITRYSNTEVCLPVEQTKFNPPSQPGNESDCFGPQNHTIKTDKKYIGNPSDGSSLEQIKHYIFPPWCAELPFTVHRGKNPKEIVAAHHQEEFNNTNWETTTFIYTDASYMEDRKGVGVSVVATDQKGTIMEKLAINTGDGNLVYNGELEGITQGIEYASVVMTRLKCNRHWRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA71</accession>
    <name>A0A0B1PA71_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative retinal pigment epithelial membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001357">
        <property type="protein sequence ID" value="KHJ33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA71"/>
    <dbReference type="STRING" id="52586.A0A0B1PA71"/>
    <dbReference type="HOGENOM" id="CLU_016472_4_0_1"/>
    <dbReference type="OMA" id="TVGWYNG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="646" mass="72262" checksum="C9F3733A0B186794" modified="2015-03-04" version="1">MTPTSDRREPHPYLVGNFAPIHESPCLTRCDFTGNIPPELAGGQYVRNGGNPLVNSDLGREAHWFDGDGMLSGVVFHRAEDGSVVPEFVSRYILTDSYLMSVTLPSLRHPIIPSMATLVNPASTLLHILGSVFRTLLFVLFSHLSGSLQPMKRISVANTNILYHDGRALATCESGPPLRVLLPRLETVGWFDGYKVEGEPATETKVGEPFGVSVGNFNILTERITAHPREDPITKELILFHSTFFAPFVYYSIIPSMHIKTNNIKPRSLINTPIPGIKSAKMMHDMGLSRRSCVIMDLPLSLDPLNIVQNKPIISYNPSEPSRFGVFPRWEPEAVRWFETSPCCIFHTANTWDDLSLVSETLELSNNVTAVNMLVCRLTSASLVYNAGNIATPALETKKASVYPVEEEQCRLYYYRFLLSETQNIITHQFALSAIPFEFPTIPQNLSMSQARYIYGCTLSNSTFGTALGGAAKIDCLAKIDSVMLLDSARVSPPTPIIGCVDNRSVAEIIKSNNKNDSIKIFKLPPGCFAQEPRFVPRNEGKSEDDGWLLSYVFDESQINPDGFARPDAKSELWIIDAITMEKIGCKVKLPQRVPYGLHGSWFNEHEILNQRPVDKTRRVSYVGPQKNYNKFNRKVIFKKILTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB87</accession>
    <name>A0A0B1PB87_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ring-finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000187">
        <property type="protein sequence ID" value="KHJ35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB87"/>
    <dbReference type="STRING" id="52586.A0A0B1PB87"/>
    <dbReference type="HOGENOM" id="CLU_1078460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="29370" checksum="97885EBFD6ED8C2E" modified="2015-03-04" version="1">MFLSNPELASINTHQTQRTSIIAQRNLILLPFRPQVRPVLGNFVSSEQALNINISSETEPSSLPDNSTLRYRRRNNHNYSQTANIHNPNNANILRREYEVAFGNTGTNGLSSLDFREAANQRAVYEKRIPIRTVIAALETVKLEELEKADCTCIICYNEFGIANPEGITELPLRLPKCKHIFGEKCIKKWLEDSDSCPYCRDKLPSEKTYKKSCGHEADRLARERLAALRQRIAHAQSLSNYFSTVELTNARISQTMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBI5</accession>
    <name>A0A0B1PBI5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBI5"/>
    <dbReference type="HOGENOM" id="CLU_042328_0_0_1"/>
    <dbReference type="OMA" id="ECAICEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="57992" checksum="E3944B2161BF2982" modified="2015-03-04" version="1">MPKDESLQRNVSQDDSTFPEADRQSNNSEQHESWKSKRAATNLFGLNRKRTHDCRLAQVDAFRNAKQKLQETLHLIEEKSTPPNIEYHSGELNCFNCDAKNKKILDAYKEYFLTSDPNAWYAQVLDYEVAMQTRFRDIKIPTKNDLKDLYIIFRTKLREYIMTVISDLGLESDIELSKMLSNNLAQDIPLENLVQKAYHALLSHLTNPDAKNFVLNLQKTRTAAERAPIYIQYYCSVAADDTPQQKNFKAKHTRMFENCLTHDEVLTAMRKEAQDLNSQRVNALYTELGELQLAQSAHIKKKLRKEENIQQVRDRNSSQKSTRCSLVGCEVELDLTKENIECAVCEWLERKCSGKGRFFYCTVKHAEEDFDNHDRHEHKCVAGHRCIYYLQAGSPAEISASGICSFCVQNKKKLFYFCSKECYHHNIVCSNVKYVNEANSIRNGMQIRIMILVINEKKPMCLKHLNVLQICKFFPKTNKLHPGVIILGYVIIQFSWFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN4</accession>
    <name>A0A0B1PBN4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative g-patch dna repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001068">
        <property type="protein sequence ID" value="KHJ34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN4"/>
    <dbReference type="HOGENOM" id="CLU_025002_1_0_1"/>
    <dbReference type="OMA" id="GPMSEVI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000495">
        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="309"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="389"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="54019" checksum="6262F6C0DD8D1747" modified="2015-03-04" version="1">MSGPTPRSGLSLYANLLDSDVDVTSEVISKGPISFKSSQTSSEPKKPFIDPAALRFQPTKRPHLAQKSKPKSSITKTNTLESRGLGNITSQVTLSTSISNPTKIVKTSLADWTNDRDEDAYYGTEKRQRGGRRKKKKNKENVPIQDWDDIYDPNRPNNFEEYQNSDEKLREVREWKDRLYAHREAKRSVDRSDSEDEDSQVRNGNMYAPPINYSFAPPPIDNPPPMPNITSQNTPTVPTPPSNVSEEANPLPEISSSSITRAPVSYSVPSDIPDGLKPDVELEETDIHDSEKEVLSNNEDTPKSRRPGQKKFAERLMSKYGWSKGKGLGAEESGIINPLQVKLEKRKKKSDAEGGGFRDAGNRGKIIGGKKSTAIVKDQDSSKFGPISEVILLNSMVDEMDLNEEVENGRDGGLIQEIGDECSEKYGRVERVYIHRTGATALVFVKFTSQLSALRAVNALEGRIFNGKTITAQFFDATKFESGIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBV9</accession>
    <name>A0A0B1PBV9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative mfs sugar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000285">
        <property type="protein sequence ID" value="KHJ35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBV9"/>
    <dbReference type="STRING" id="52586.A0A0B1PBV9"/>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="OMA" id="PRWYLTK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="164"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="691" mass="77490" checksum="CF97F8FF4D5BD625" modified="2015-03-04" version="1">MSFELSDEKKTDRDDNQDQKISSSPPTPDAVTKVESQGRTALESYNDDLDGRTEVGQSPIKAVGGFGIRQEFLSLEHLRATINARLANPLAGFSQQQLTQKGLEFAMKHGMKGPEDVRAFKLGARLAQDFNAYRHIEELSAQEFNDIEHEFTHKWSLPWSLILVIVLCSFCAAVQGMDETVINGSHIFFAREFGIDNVKSSRDTWLLGLVNAAPYLCCATIGCWLTIPLNDWWGRKGTIIFACIVSAATCIWQSCTSTWWHMLIARFFLGIGIGPKSATSPMYAAECSPPSVRGALVMQWQLWTAFGLMSGLIADLCFYSVPDSSNIKGLNWRLMMASPCIPALVVICFGFLCPESPRWYMAKGRVANAYESMVQLRFNKVQAARDIFYIYILLEAEKTGVDLGQNKFKEMFTVPRNRRALQASEIVMFLQQFCGVNIIGYYSSAIFLRAGFSEISSLGASLGWGTINFLFSLPAIYTIDTYGRRTLLLMTLPLMSICMFFIGFSFWIEGPAQIACVALGIFLFVMCYSPGASAVPFTYSAEAYPLYIRAQGMSLATSTTWFFNFLLTVTWPSLLKDLKHQGAFAFYAVWNIIGFFAVLLFVPETKGKSLEELDNVFSVGSREHAAYGKNQLTHFFKKYILRKKVDTERLSFSSSQNEKPTKHLSNDMEMGATSSRLPPILGHPEQDYVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY8</accession>
    <name>A0A0B1PBY8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000661">
        <property type="protein sequence ID" value="KHJ34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY8"/>
    <dbReference type="HOGENOM" id="CLU_017633_13_3_1"/>
    <dbReference type="OMA" id="EPRMNKR"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="107" mass="11754" checksum="FED1AE93F7953898" modified="2015-03-04" version="1">MASLAVIGVGVAAAAFLGRAGLLAFRRSRSAELGGTFGKAYFKGGFEQRMTRREAALILQLSERQLTKERVRKSHRTLMMLNHPDRGGSPYLATKVNEAKEFLDKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC05</accession>
    <name>A0A0B1PC05_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000105">
        <property type="protein sequence ID" value="KHJ36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC05"/>
    <dbReference type="STRING" id="52586.A0A0B1PC05"/>
    <dbReference type="HOGENOM" id="CLU_012079_1_0_1"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="462" mass="51067" checksum="1A7DAB505EBBFB1F" modified="2015-03-04" version="1">MIYIVLTIAVAILISCKLLALILPSRYHPPSLQEPAQGILSSVPNVSVQILVLGDIGHSPRMQNHALSISKKGGQVSVIGYEESSVHPELCSNPLVTIIPLPQLPKFPFPFKLPFAVVAPVKVMWQVWSLFMALGYRTKPSRWLLVQNPPSIPTLIISIIICFIRQTHLIIDWHNLGWTILAGKKGASHPYVTIYKYYEAILGRWAATANFVVSNSMRRALQNPPYNICSPIFTLYDRPALDFQPITTIQTRCHFLEQLPETSNFARSILSGSTKLIVSSTSWTQDEDFDILLQALCSYASCSENLPSLLVIITGKGPQKQHYLDCISSLNSKKKLDNVFICTTWLSTANYAALLASADLGVCLHKSSSGLDLPMKVVDMFGAGLPVVGYKAYESWKELVIEGVNGRGFVSGEELSSILQELLSDKNGEKLAKLRAGALNEGKKTWDEEWNRVAARVIGVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC36</accession>
    <name>A0A0B1PC36_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2911</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000093">
        <property type="protein sequence ID" value="KHJ36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC36"/>
    <dbReference type="STRING" id="52586.A0A0B1PC36"/>
    <dbReference type="HOGENOM" id="CLU_031067_0_0_1"/>
    <dbReference type="OMA" id="QHYLARC"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="48698" checksum="F71B889B1FF2DF7A" modified="2015-03-04" version="1">MEFIPALRSKFDSHKPSLFELISEAQLSSLLPPTLRYLLTIATHRHPRYLLRILNSFDELYALLMVIIEYHHIKIYGGGFTENFYGLKREKVPTVGEIPRTRITASSHVREALALKSFDIWKSVAVMVGLPYLKRKLDESYEINNQRALLGAHFIRLPANPTLGQRFTHYYRSFLRKVYPSLNATYYFSILLFNISYLYDNSNYHSPFLWLIRTRMRRLSDSDYQAISVTKSTNKETKNRLNRDWVLDCFKALLPTSIFALKFLEWWHASDFSRQLSKKAAESIDLSPPVIEDPPCTTREVVLSNEKVQDTETKEKLKDEQPMSSDRPIASKSLLPIFTMPLSKDRGSCPICQEDITTATVCQTGFVFCYTCIHRWLEGNHDKQIEFMKGKQGKWESGKGRCAVSGRRVLGGTESLRRLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC77</accession>
    <name>A0A0B1PC77_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000601">
        <property type="protein sequence ID" value="KHJ34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC77"/>
    <dbReference type="HOGENOM" id="CLU_633397_0_0_1"/>
    <dbReference type="OrthoDB" id="3589351at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="433" mass="49336" checksum="083186987A4289EF" modified="2015-03-04" version="1">MFGNNRPVSILHNQNQSIDDFPLPPCTPRHGSLSNAMQDDSVPEFDRNFRFPNNDVSTNHDDDLDDPEHTFMRLKNEVEILTARLARDFTDLDSSISSQPQTKNYPNETKCRISTRNIDTRPKTSYGRVEAPRFSFRDFDGWDIKDERDETRMAGRYGDNHVQQQQISTRARASSLRNCQTQRQMKDKPNLVIPVHARKYLIAQERARIDQEREAEEERRRILAQTREAVAHISEAGFDFGFEGTGPMVDEITKCSKVIPATTPETAESESNIKTTVIKIPPKEYQLISTPPSTHNSATVAWPSRAESTHWPGWGHSDSGVALASPPLSPKSAPPPITCFPDLPEPLRVTRTEKLSPSTSLNVNEKFTKPSRQELSCWSASPDISQNENLGYLVEEVDDKEKRRGFWRRMKSSVFSRKKSTFKTKEFVEISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCC8</accession>
    <name>A0A0B1PCC8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000208">
        <property type="protein sequence ID" value="KHJ35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCC8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCC8"/>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OMA" id="NMDYDKG"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21179" checksum="C89650DDA90BD145" modified="2015-03-04" version="1">MALSPQITNLVIILGMMQVSKRIPMDDPDVLNMIRAGYVLSNFIILSIYLYVHYRINKKKDLTTLKYIDTPPMGSAEEPKLITTTIHAYDVSQMKTLYKAQLMGVGMMALMHLYFKYTNPLLIQSIIPLKSALEGSEVAIHLFGKAPVADLKRPFKAPPGLLSSLQGGAAQAQDKKSIENAEKAGRGGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD6</accession>
    <name>A0A0B1PCD6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fad-dependent oxidoreductase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000204">
        <property type="protein sequence ID" value="KHJ35923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD6"/>
    <dbReference type="HOGENOM" id="CLU_571342_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="478" mass="53718" checksum="16334623DE31EA84" modified="2015-03-04" version="1">MNSQSSGGLVLVNAQSDGHTQSSSLSSLSSTPGASSPIIYPSDVAPTSKIFSITPPPSSYQDSARSKKLASLVGSSSPVAEMKIGAKEQSIISGRPTPDLIETATKDELQKMLKISLDEILKLEAASCEARMSAAHRKLHYNLLSIESQEALNRMEVENYMLRRETLILRKNPQNQAQTQYKKMLEGYCKYLKEENLVLHYRLKKAKSLIKRYDLKLASACQEINLLQDRIRQNRRYINEMRRPGGPLLNTFTSLSHTEISKDSCTHYYNNMTQKNSHLHPKPPDLIPENREKLDVLLLAGSILDQENNKISSPIMANYGPPDTKQLQNQGLQAICQPEASCPSQISNALLPPIRLQVQVDKTLKSPLRTSSQLSTRRRKSRDSTISVSECDEQSASQKNENKVPDSDILFKQVNASCSKNKVGTKLANEKLCNDNQELYNSLFDTVMTKRRREDELSWWNIESKKSRHNEILSLTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL2</accession>
    <name>A0A0B1PCL2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000027">
        <property type="protein sequence ID" value="KHJ36422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL2"/>
    <dbReference type="HOGENOM" id="CLU_633396_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="433" mass="49775" checksum="DE90AFA21F436D20" modified="2015-03-04" version="1">MPLHSTLKPICDSSLQLGISVVLKLSSIALVELLGHHRQSKYFNLTSAENLTHWSHPLIYYGIQGRYKSNLLREFPIIVSSFTQFDVELIPHYTILSPTSRRLYIGFEFQHDALKQIKLAFSKWGGEGFPHNDFLRSSSKSGLGPHIFFPIKVMKTENEIQAQDITREFSIVLTKFGNIFTADSLLLQEYSTNSDGTPKQFLTLASHPLNSSKYWKLQGLSKLRMLSLKEELMSSTIRRSTSISTSETLSHQVKIRKIMGTPKDNHLEWMRQQYVETEFHPGLLRKVKSKKISPKSSFYYSNDISMPTLGNQIIKFKDKRFVQGVPTNLKNFGLEKECIANPLSLEKITFKENKPNPNISNSLFSNNTSNSISSCSRQEARRLETERLNRPLIRYEKSSLIIRYNYFTYDIPLAKYKCYIRHINGDIALEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL3</accession>
    <name>A0A0B1PCL3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000169">
        <property type="protein sequence ID" value="KHJ35998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCL3"/>
    <dbReference type="HOGENOM" id="CLU_059580_2_0_1"/>
    <dbReference type="OMA" id="ETKHRVY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="25640" checksum="997308BFF2986988" modified="2015-03-04" version="1">MADVLKSNPPSLLFKKRKAENYENNERLSKRLSLLNLERSGQKLFNPPQPPIACKQDSISHFINQPTSNSDLMQIEDTKNKVFIHDLEAEILEVQSEEAKFIIHPEIEKHLRDCRFSPQIITSFSSSHEDKQLVLYNDPSSITIPEEFDSVKRIIIETRSRIREKQDTQNKEMLLEQPAEQLSGRSVDNQPSYYQPNSIFDSNSSQQHQENDPDIMDLDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD18</accession>
    <name>A0A0B1PD18_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000683">
        <property type="protein sequence ID" value="KHJ34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD18"/>
    <dbReference type="STRING" id="52586.A0A0B1PD18"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="KCCRITR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="29491" checksum="11D713964FA16459" modified="2015-03-04" version="1">MNTSTYDICLLISTGEHFGLVGMQIDDTLFLADNKIAELENLELQKVGFLAKQVEILSLKHSLIFNGCKLNKISDCIELVQKGQADRLKLVEVDAAQHQDPTIEEIKALNERLSWQINNKSRGLNYIPIDLSTAKLMVFVDGSFANNRDYSSQIGYVLTLINESLSDQFFNIQGNIIHWSSVKCCRITRSVLASELYTMVNSIDVTIAVPTTLNLITEKLNLNNIPLIVCSDSFSLYECMVKLGTTKEKRLMVDIMAIRQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDR7</accession>
    <name>A0A0B1PDR7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000531">
        <property type="protein sequence ID" value="KHJ35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDR7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDR7"/>
    <dbReference type="HOGENOM" id="CLU_047148_1_2_1"/>
    <dbReference type="OMA" id="FHVDTEI"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="40272" checksum="9575CA91CAD4F8C9" modified="2015-03-04" version="1">MSLRNFSTSGFARQARCKSPVIPNTSIKIFSRIQSFRQWRRRQIFDHRSVGLVPTMGALHEGHLSLIRLAARKNAAVVVSIYVNPSQFGVSEDLDSYPQTFDKDIQLLRDLDNDLACDGSNFGKIAAVFAPTTSEMYPDNCFSQEIGGNGSFVNIKPLDELLEGTSRPTFFRGVATICTKLFNIVTPDTAYFGQKDIQQTIIIKKMIKDFCIDTEVIVGETQRESDGLALSSRNQYLGTRRRQVATVLIKSLRLIEEEYLKGNRMRDSLLQPALNFIRTIKDEQDRLGEVGVQFLLDYISLADPQTLEEVGEVNEDKGAIISGAIKMLPLDNPSPNEYLGQANGPMVRLIDNIILSPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE39</accession>
    <name>A0A0B1PE39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sulfate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000488">
        <property type="protein sequence ID" value="KHJ35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE39"/>
    <dbReference type="STRING" id="52586.A0A0B1PE39"/>
    <dbReference type="HOGENOM" id="CLU_003182_0_2_1"/>
    <dbReference type="OMA" id="ENEDFWF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="569"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="761"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="896" mass="100534" checksum="2457BD15673FB0C4" modified="2015-03-04" version="1">MDGEMTENGMGQRPRTMNSSDLRPSLTERTALLKRKIVWNGHNRFSRLETQQEAYMCEMKFRKFRKRIHKIIIRFKSTGCNIARLLSNPKTWNGEVIWKKAILAPIEVLPAVALGLLLNILDALSYGMILFPLGEPLFSKLGPAGISMFFVSCIVSQLVFSCGGSVFRGGVGSEMIEVVPFFHLMAGTILKEIGDTNPSAVIATTILTYAISSLLTGAVFFLIGYLKVGHMVGFIPRHILIGCIGGVGFFLMITGLEVTARLDKLEYSLLTLHRLFQPDTVSLWVIPLALAVLQISTESIIDFKYFLPAFVLTIPVVFYFIIACFSTLNVSNLRNDGWIFQSPEAGESWWYFYTLYNFRIIRWDSILKCVPAMFALTFFGILHVPINVPSLASAIGEDRIDLNSELLAHGASNALSGMFGSVQNYLVYTNSVIFIKSGGGSQLAGIMLAIATGIVMMMGSLIIGYIPIMMVGALMFILGIELLKEAVWDPRKKLKSLEYLTVVTIVIVMGIYDFVIGIFVGIALALVTLVFQTSQIPAVRAIYSGEVVGSTVHRSPIQHRYLKKVGGQICVVKLNGFLFFGTIANVEDRMRQIIEKDEFDRRPIRFLIFDLFHVTGLDFSAREAFGRINRFMCKKGIQIIMSGLNNRVELRLSLEAVDLCKDDKIQMFEDLNLALESCENVLLRTFHSNRDAQIELLKKTRGLDVPVQNSSDLYTSINQCNTPRGNQLIQVATNTLNQGLNEMRFFNIRGPLHIILQSFGALTILEDEFWYKAVPYFNRKDFIANTIVYQSGDQANDFFLLEQGIMYAEYDLPQGNFCEKIVACTTFGELPFFSDTTQTATVVAESDCATWVLDRENWISLQKLEPELAHELLRVVLKITSDRIKSITNYVLTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEI1</accession>
    <name>A0A0B1PEI1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADK2</name>
        <name evidence="8" type="ORF">EV44_g2711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000448">
        <property type="protein sequence ID" value="KHJ35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEI1"/>
    <dbReference type="SMR" id="A0A0B1PEI1"/>
    <dbReference type="STRING" id="52586.A0A0B1PEI1"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_1"/>
    <dbReference type="OMA" id="TIAHFST"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="264" mass="29588" checksum="AACCBA6D4EB70983" modified="2015-03-04" version="1">MSLRKPARIIFIGAPGVGKGTQTARLQKRYPQLSSISSGDILRDNIKDQTPLGVKVASTISAGQLVPDSLILSLIIHEFQKRGWSFPLHKKPSINSLCPSISGNTNSFVEHPSITDTVTSLKNSYDSSISFILDGFPRSLDQAQMLNELIPINFVVSLKTPISKIIERINGRWIHAPSGRTYNSTFKKPKVEGIDDITGERLTKREDDNIETWENRLKQFQKTSEPLLSYYAEKGLLWEVEGDSSDEITPKLFLEVEKRFGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEN7</accession>
    <name>A0A0B1PEN7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000423">
        <property type="protein sequence ID" value="KHJ35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEN7"/>
    <dbReference type="HOGENOM" id="CLU_2623843_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="78" mass="8568" checksum="2EECECC3668DCD8F" modified="2015-03-04" version="1">MESQNITNLFLPHSHYCIPSNLKTPSSGFQLQQQVVPDPSQRQTPHGAYPRGGTATSSPLASLDGWHTPSDARRPEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PES4</accession>
    <name>A0A0B1PES4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PES4"/>
    <dbReference type="STRING" id="52586.A0A0B1PES4"/>
    <dbReference type="HOGENOM" id="CLU_009422_1_0_1"/>
    <dbReference type="OMA" id="FIVCLNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106339">
        <property type="term" value="F:tRNA (cytidine(32)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="397" mass="43915" checksum="47EE1B4FD9A44429" modified="2015-03-04" version="1">MGKSSKDKRDAYYRLAKEQGWRARSAFKLLQLDEEFDLFSDVTRVVDLCAAPGSWSQVLSRVLVKGEKFGRAAWEDKEQRSRQDLLKIFDVGSTATQYKSDCTPEKNKISNLAPTESGRPRDVKIVAIDLQPMSPLHGIITLRADITHPSTVPLLLNALDAKLDSNLKSPQACNLVDLVLSDGAPDVTGLHDLDIYIQSQLLFSALNLALCVLRPGGKFVAKIFRGRNVDLLFAQLKIFFERVIVAKPRSSRASSIEAFVVCLNFSPPSNFKANMDDPIGVGNKALKIIAQQRMHEPIISSVILQNPMTGEWSANQSFPMIMTGDSSVKILPAECETSVLQSGKWIAPFLACGDLSSFDSDATYHLPKDRITLDPVQEPTAPPYKRAIELRRMNGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEU6</accession>
    <name>A0A0B1PEU6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000498">
        <property type="protein sequence ID" value="KHJ35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEU6"/>
    <dbReference type="STRING" id="52586.A0A0B1PEU6"/>
    <dbReference type="HOGENOM" id="CLU_005882_1_0_1"/>
    <dbReference type="OMA" id="RYQGFCK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="994" mass="114885" checksum="F350DF62A5BF2F0F" modified="2015-03-04" version="1">MAPMTRSQAMAPQVSQEGEWTETERFEERELSERSISSQDGENGIFNERQDVESESNSYYEFNKMPLRGPEDEDDVLHPLRATVDRVGTEVEQFAQILDRFNPQRITDKTERQEMMFELIDKFHNIALKTVDSLREKHASERRKLEGRKWRKKMRGLKITQENDLQVQNLDGLDSTELGSRTTIKDLDHWEQEAQTWDLLKRLATVRFGTKLQDHKLNHFYVSKKELYDHFLATEELALERKTVLQWLKDTAEESGEDIDVLVEDLQQNAERGDIIAHGWLHTKAAIKDHKRRTASSHALDPKAQNVEKVLLNTARTEPLTTQLDPDAPNRQGRRLATQDQYFERAIWLGCYELLRRGNSLSKISEWCMERTEIWRAVSMSGVSFEDSEEDRNFASPDVMIRWRKICLSIAHTIGNSEYENAVYGILGGDISSVEPVCKTWDDFMFVHYNSILRTQFDNYLKNIQLQITETRPYVPPKNTDSAQNFSEPQDSRQRLIAILMTNPKILKESKKPMKILQGVLIADQFSHFIFQQGLALSQIANAKEVSRVIPPSKHQLDDVDLTKYVTFDDHDSLRVLTHVLIIFMGLGLDLGDVYRETEIQNVMVAYITFLKLAAKEELIPLYCSQLSGIRKYSILSRNLIDIIDEDQQIVQLKLMRKLGLDVQEFVSLQARYLLDDFPDSSRDFLALGNLKLFSDNYESSSLFRTLKKDFISEKYSAGRIDLLLIRSLKWYLLVDGLWVESFRLGTLLYLRFFKHMNLHAAKMLSINVPSKVLMERKTRAILGESLNLFNSNIDFINEESSTGALKAYLLNEARNFRELEILIECLDSIDTANCLVEIKKQGLSNQKPPILLREWRSDYQTACEESHSCARLLMKGWLLKSPNESIKNDLEHIRQAYLPEILIAYITTLQVAGLYLNQDFLLEAMEVSSILADEDSDVLETFIRTGRLHEMVDNLARASKTLLTVSSSKQKSVSRSIRLKKQGRTLKLWNVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEW3</accession>
    <name>A0A0B1PEW3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease h-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000492">
        <property type="protein sequence ID" value="KHJ35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEW3"/>
    <dbReference type="STRING" id="52586.A0A0B1PEW3"/>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="OMA" id="GITWLEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="34172" checksum="1A5BE1C3233647CF" modified="2015-03-04" version="1">MIKLKQTQLKLIAFKCGLNTSGTKPNLQARISRELNCISLAQADSYRVLSIDMGIRNLAYCTLDVKLDCPPPRIHAWKNLSVFMTPVNLSLRDTEEQPLQEKEAFDPETMSATAYTLLREKLLLDQPTHVIIERQRFRSMGARHIFEWTIRVNMFEAILYGILCTLKAEGMWKGTVIPVAPLRVGPFWLGRDDEKGNFKNTGSRNKRRKIDLVKSWLENDSPIVQFGNKEALDVAGRFLKNTSSRFKKPSDEDYTGDISSRFGKLDDLTDALLQGLAWIQWEKNKRIALRDGVEALLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF48</accession>
    <name>A0A0B1PF48_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative rsc complex subunit rsc9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000472">
        <property type="protein sequence ID" value="KHJ35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF48"/>
    <dbReference type="STRING" id="52586.A0A0B1PF48"/>
    <dbReference type="HOGENOM" id="CLU_008152_1_0_1"/>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000021">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="636"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="930" mass="105516" checksum="187CFA1735912F8E" modified="2015-03-04" version="1">MAPAQTLRELSLERSSEYVEFISKLASYHQKRGTYFDPEPKVGTKHMNLFQLYKAVTSRGGYDVVSDEKLAWRKLGQEFNLGSSNLPAIAFQLKGVYYKYLAAYEISTHWGEEPPPKEILEDLTARGGGLRTRTVQNFVPPGKRDGGPNDFSEASGDDGTPSRERNVSEDTPGSVGRATRGLRQQPPQRIIFQPDTGPARQSRNISTTSHPPQPQNHFQNIQQQQAIQVPRGASTSYNPANNFEISSTVTNYEPRSQIPLTLRPIITPANNPIEFARRKKILEENRKTQGSGRTQRQNKGVILPGSGFEGPNIYVRCLCALRSGIPAEQDYALHHLVKISMERGDKYRFEGFPGLAEGLIEKLLEVSSLFYEVKWNLKYVYDDDQNGDTLNGLDGTPDILEKISQLKKIPIDDNIQEKEFGDNLLRINEAALTLRNMVMLEENALYVSELPLLRDLLSIILNLPNLDSVVELKHYALDIAEQITKYLHLDENDPLFISLLNQIYLEDRGSILTALRAIIRISMNLEQNNFLRGVPIKIIERILDCILLYDEDLVSTCLDFLYQYTAIVDNVEPMLSKGYLEPLINQLVRFLLFDARTVENEISTGNDCRIPAPTSIAPIPQELFVQLMSREEPERSSLWLRCLFEEDAMESITQIALWQAYQSCFSSSVPESGIPLLPAADFIKNVSTTFADKAAAQVQPGAVQKFIIKGIRYRKIPVDIKGDEFHKCCWRCPNKESTACNQFFMSPQCMYQHILTTHLAAYQREDGLFNNSSDNLYTCGWNNCQRFVNEPARKLSQIASHIKVHLPPPTFNSPSLARENHVQPAQPPTKKHKPSYIVQSKRRKFVYHVTAVDERQEAAGIPLTAVLILRNLTRTLPKIEPNESTIKTKDTAPWVDQFFKPIEPRLFEIMAYNKSLTLYMTDLLNCIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF98</accession>
    <name>A0A0B1PF98_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome b-245 heavy chain subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000171">
        <property type="protein sequence ID" value="KHJ35990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF98"/>
    <dbReference type="STRING" id="52586.A0A0B1PF98"/>
    <dbReference type="HOGENOM" id="CLU_005646_3_0_1"/>
    <dbReference type="OMA" id="FTFAKEH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="240"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="552" mass="63908" checksum="1907FD3413CBE5C4" modified="2015-03-04" version="1">MGFFKILAKQLQGSKLVFNILFHGLHVGLFIYGWKKQQNDPRLAGLNTLKFSVWISRGAGLVLSLDGAIILLPMCRNILRYIRPKLKLIPLDESQWFHRQVAYSMLFWTPFHVIAHYTNFFNVEKTQIRKVTALQIHYKQVGGITGHVMLVCMLLMYTTAHHKIRQQSFEAFWYTHHLFIPFLLGLYTHASGCFVRDTPDSFSPFDHDNFWQHCIGYEGWRWELWGGGLYLVDRIYREIRSRRDTKVVRIVRHPYDSIEIQFKKPSMKYKAGQWLFLNVPCVSRYQWHPFTITSCPFDNYISVHVRQVGDFTRSLAEAFGAGKEQLKMYEDLDPNSLYDIALEHGKIMPEIRIDGPYGAPAEDVFDYEIAVLIGTGIGVTPWASILKNIWHMRKNTDPPIGLRRVEFIWVCKDTTSFAWFQALLSSLEAQSDEACRASGKGDEFLRIHPYLTQKLDDDTSHNIYLHSVGASVDPLTELKSRMNFGRPNFSKMFKQMSDDISNGTYLKGYRPNVKMRVGVYYCGANAAVPGIKKACREATTSDVKFSFWKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFB0</accession>
    <name>A0A0B1PFB0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fatty acid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFB0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFB0"/>
    <dbReference type="HOGENOM" id="CLU_002329_1_0_1"/>
    <dbReference type="OMA" id="INEWGRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1033" mass="117021" checksum="F8ED417C77B0E719" modified="2015-03-04" version="1">MPKSNNYLTDIKKLDIKDLKTLFLLFEAQIKGKQDDNKYLLENLIKLLAKWNQGSKIGDKLTNAFISDLWNALEHPPTSSLGSEYMYRAADGGFNNIRIPDLGRSGTPYARIAKPVKLQNIALPDPGVIFDALLVRENKFQPHPNKISSMLFYLASIIIHDIFRTDHYDFNISNTSSYLDLAPLYGSNQQEQDTVRTFKDGKLKPDCFSEKRILGFPPGVGVILIMFNRFHNYVVSKLAAINENGRFRKPSNPSAKDEWIKYDNDLFQTGRLITCGLYVNCVLKDYVRTILNLNRTDSKWNLDPRTEEGKSLFDIQVPEGVGNQVAAEFNVIYRWHSAISERDDQWTQNLYSNLFPGKDSDEVTLEEFLRTLDEFEKKIPNDPMDRKFANLSRDSDGKFSDDDLVNILETSICDISGSFGANTVPKILRSVEILGIVQSRAWRMASLNEFREASGLLRHKTFEDINPDPTVCKKLRNLYDHPDCVEFYAGLIVEKPKPPMNPGSGLCVNFTTSYSILSDAVSLVRGDRFFTTDYTAKHLTNWGFKEVESDTSIDEGCVLFKLILRAFPHHFKDNSIYAHFPFVIPDENLKIQRTLGRANKYCWDKSKREIDPVVLKSHAAAQMVLNDQTNWKFIGDQNISLLQINSSNSAHPDQLETEVKEFYQKTAAQLFKEYTFEDPGKRANQVDIVRNISNLVNTRFAAYLFNISIKTNENPSGKFMDYEIYKNLALLYTSSALNYDVAKGFELREAALKLNNQLSKLIIKNIDQIRSPGLFSQLRAKLNKSAILPPIGSTLLQKIVKDKISSTDIVLNHVLPTAAFIAVEWSQVFCQAVDFFLEAGSRFLPDLYTCSHANTPEADEKIERYFLEGVRLSSISGIYRIYQPLSNDDAPMTEIQDGAQTFAISKGQRVFVDLPVASSDPNIYSDPTEVILTRPLDTYLQYGFGPHQQATSKDISIIAMITMFKTVFGLKGLRRAQGSGPNGSWAWGESQGQLKKVEIPPPLPGVSSSSYMTRDQSNFCPFPTTMNISWDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFL3</accession>
    <name>A0A0B1PFL3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 40s ribosomal protein s23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000305">
        <property type="protein sequence ID" value="KHJ35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFL3"/>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="145" mass="15839" checksum="D7E0F0E32EE497B5" modified="2015-03-04" version="1">MGKGKPRGLLAARKLQNHRRDQRWADLSYKKRALGTAFKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLSALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFM6</accession>
    <name>A0A0B1PFM6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000302">
        <property type="protein sequence ID" value="KHJ35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFM6"/>
    <dbReference type="HOGENOM" id="CLU_1918622_0_0_1"/>
    <dbReference type="OrthoDB" id="10379193at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14651" checksum="072D81EF32B05EDE" modified="2015-03-04" version="1">MRLTRVEIHKEEDIDVLGDLSKVTDATQNLNGVQTNPELVFEAVKKLAQQSVGEGTAASQLEKANKNILEKEKQFLMSLKEMEEAKEGLNEREKFSGTTTVLGRLADVLDRLQIPNQKPAIINSGQVFNGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFN2</accession>
    <name>A0A0B1PFN2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFN2"/>
    <dbReference type="STRING" id="52586.A0A0B1PFN2"/>
    <dbReference type="HOGENOM" id="CLU_003016_2_1_1"/>
    <dbReference type="OMA" id="HPCHELR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="161"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139022" checksum="A3E1858013FC17FC" modified="2015-03-04" version="1">MSIHILVCESPYRSIALITTSYALTFRCYPSDSNINKNVVVPGLSTEEAATSRCIVEFQSKKSIDLNNYQPLSPLPIHGTLGLITVNNNIFICVVTGATRVASVRPGETAEKIYGVEFYCLNTSNYDNSPKEVSDQNNLEDGFLANIRGKELSQEHPCADLQRLLCDGSFYFSTDVDLTNRLQDRDIEVNNLDIDHMDTDFLWNSFMINPLIKFRSQLLRSERKNLDSSRTLTSAIRGFIMTLMIPSSPSSLLNEENGAPSSLTLISRLSCRRAGTRFNSRGIDDDGNVANFVESEIVYYSPLVNSLLGDVEPSGICFSYVQIRGSVPIFWEQAAGLIPGQQKITMTRSPEGTLPSFHKHFSELERKYGLVHIVNLLSENKASELELANLYRKAVKNAKDKWSKENYFLDPQFLKQTEFDFHAETKGPGGYESATLIRRLIKSSSNEFSYFLCEDQIYSAEDYPNAKGNRTFVISHQKGVFRTNCLDCLDRTNLIQSIISQMVVEAFLAHQNKHVSPDFWMSHSNLWADNGDSLSRIYAGTGALKSSFTRHGKMSFAGALADARKSATRLYINNFADKARQQNIDFLLGRSIGQKAIHLFDPINEYVMTELSKKTSKYRSFKTIKIWCGTFNLNGRNISTEYDLSPWLFPSLDHTQESPEIVATGFQEIVELSPQQIMNSDPKRKEAWEKLVLDTINKKEKLNGNEYYVMLRSGQLIGASLMIFVKKSALFNIRNVEGSVLKTGMSGMAGNKGAVAIRMDYADTPICFVTAHFAAGFKNYEERNNNFATINHSLRFQRNRGINDHYTVIWMGDFNYRIALDNEIVRNLIKNEEIDILFQNDQLNLQMIAGLVFPSYSESKITFAPTYKFDVGTNTYDTSEKSRIPAWTDRILLKGENTRQICYNSAPLQFSDHRPVYGIFLSTVSITDEQRKESLSRQIFEERKSHVNDAISEKNNNNKDKSKLSILGSNLDIVNSERTHSQLLSQKIKLPTPQKSGNTLNKSYSVIKPQKPPKPPVIGPSLAVSNNSNTPRVISKKSSIASDIKDVSNVLEYEVLKKSNLTDHEGLHNSSLTPTSAGYLNSDRSKSSTYAPSRQVPPPIARKPLHLTSTTKLSSTTSIISPTSKALNGSPPISISETKNIQNREPHGKVESKKSKDPPPSPLPRNASRVAKNPPLSLQPQYVSKGPWLTSKESYISNKNVSKPNVPPRKKSSTTLLEGDLDSSINGWKALEPENQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFZ7</accession>
    <name>A0A0B1PFZ7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1198</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000109">
        <property type="protein sequence ID" value="KHJ36215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFZ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFZ7"/>
    <dbReference type="HOGENOM" id="CLU_001485_3_1_1"/>
    <dbReference type="OMA" id="FPMGTKQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="3"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="877"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="499"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="751"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ36215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="925" mass="103210" checksum="CD04025A451C285F" modified="2015-03-04" version="1">MTSIKVVARFRPQNRTEIELGGQPIVNFESEDTCRLESKDASGSFTFDRVFDMNSRQKDVFDFSIKSTVDDILNGYNGTVFAYGQTGAGKSYTMMGTDIDSGDGRGVIPRIVEQIFASILSSPSSIEYTVRVSYMEIYMERIRDLLAPHNDNLPVHEEKNRGVYVKGLLEIYVSSIQEVYEVMRRGGNARAVASTNMNAESSRSHSIFVITITQKNVETGSAKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINNLTDGKSSHIPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNAEETLGTLRFGMRAKAIKNKAKINAEISPAELKALLRKAQSQVTTFEQYVQTLDAEVQQWRSGDSVPKEKWVPPLDTANLSKIKTPRPATPSRLQVESRSEASTLLDRSSTPIALEKDDREEFLKRENELQDQIAEKETLIATAEKKLKDIKEELSYLKERDIKSIRENEKLIGEVNDYKMQTERLSFESKEAQITIDSLKDANAELTAELDEVKQQFLEVKMSAKETTALLDEKEKKKAEKMAEMMASFDLGGEVFSDNEKSIQKLIEKVELLHLNSSAGEIIAPDELSDFRSALIETQGLIRQAELSIYRSSDDALASKRKQELESRLEVIEREYEELLERNLSEADVNDIKERLAHTYSNKQDIQSSLVADLKADLAQKSAELQMFKAVNEDLQSKLQANSTGAAGSITNGKTVQQQIAEFDSMKKSLMRDLQNRCERVVELEISLDETREQYNNVLRSSNNRAQQKKMAFLERNLEQLTHVQRQLVEQNSGLKKEVAIAERKLIARNERIQSLESLLQDSQEKLTAANHRFESQLLAVKERLEAAKQGSTRGLGSPGDGAFSFSGAGSRIAKPLRGGGGEPASIPVISNLQNENSSSSNTSKRGSWFFSAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG15</accession>
    <name>A0A0B1PG15_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000258">
        <property type="protein sequence ID" value="KHJ35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG15"/>
    <dbReference type="STRING" id="52586.A0A0B1PG15"/>
    <dbReference type="HOGENOM" id="CLU_025524_5_1_1"/>
    <dbReference type="OMA" id="HKRLAWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="393" mass="45215" checksum="980320EC9F5B74B6" modified="2015-03-04" version="1">MDETILTSLCSICYIDPPIYTCPRCYANTCSLNCSKRHKIWSSCNGIRDPTIYKPMSQVATPSGIDHDYNFLHSIENGISRSEKILIEDLGLVSREELKRARNCKDDKSFGNKRQKKFISEFPGEFCINKLTQEKNIQVMRAPKGMRRNKENTTSWNRKRKTIDWQVEWLRKEPTGINRILHKVSGINPIGTQYDSICEEERLMKMTDDERRENKRRKTQEYKNFTAKSMKMAAELTMKAPLVILQDPERMTWNINPSINTTLDLLENEEIASRAAARKYDLYIHRPLTPASYPKVLASIDPEKTLTEILSDRCILEYPTIYVFDKGSSGLPDGYMSEQKFLEITQTLQSNNQPKSLNNTAEDIEKESSKISFDSTESSYESENSDSSSSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG17</accession>
    <name>A0A0B1PG17_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative substrate binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000101">
        <property type="protein sequence ID" value="KHJ36235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG17"/>
    <dbReference type="STRING" id="52586.A0A0B1PG17"/>
    <dbReference type="HOGENOM" id="CLU_045518_0_1_1"/>
    <dbReference type="OMA" id="RMPLMFG"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="317" mass="35467" checksum="99F01DD1AB7A00FD" modified="2015-03-04" version="1">MQLIGMKNKVLITGATGFLGRQMMKSFEQANWEVTGTGLTRAVSPIIKLDLLDSEAVARIIRIIQPCVVVHCAANRYPDKCSNDPEGTYALNVGSTSSLAATCAAQDILLLYISTDYVFSGKLGEAPYEVDSKPDPSNFYGVTKLKGENSVLDTYENAGMKGLGVILRVPVMYGEVKTPSESAVNVLLDTLLEARKKNRQVFMDHWAIRYPTNTEDIARISQDVASKYIATNDKSKLPLVLQYTSEQRYTKYEMCSIFAKIMDLPQDNIIPIETPNDDTPRPYDCHLSTKQLREIGINVCSVDFEDWWRREAEALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGH7</accession>
    <name>A0A0B1PGH7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000178">
        <property type="protein sequence ID" value="KHJ35971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGH7"/>
    <dbReference type="HOGENOM" id="CLU_714097_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="278"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="387" mass="43740" checksum="431D155FE9A80DAC" modified="2015-03-04" version="1">MSAAQTLKSMKNAPRLDKATYDRWSAHFLDVLSLFNLEKYDLEDTSQLVADKVKLEIKVNLEYQKQDRNIRVALSQLTPDTAFNLVNSSFTSKIYWENLKQFNRPNSNEDVDDLLQQFWGLIPEDEINIDEFVRQMSEIRGKIFLINNNTAPSKCSMKKRLLGHFIKCYNGFYMSTVISLRDPTITFQVAVSLIRASQEVYKELHPPSIVVLVDINRNNDNLSSPAAQSKSAVEEKGNPNTSKNASLNGAAGELQIGAWMMEEQSLISIRSVCESDLVFDTGTTNHTLNDQRLLVRIDPVEKLILKASGDSNPVSRVGNVEFKVFNYENEKLFKVIKMEDFWYVPKCTKNLVSGVWLLSKGYQIKSSNGGLSVMSGDSKIIATAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH05</accession>
    <name>A0A0B1PH05_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative e3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000131">
        <property type="protein sequence ID" value="KHJ36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH05"/>
    <dbReference type="STRING" id="52586.A0A0B1PH05"/>
    <dbReference type="HOGENOM" id="CLU_055856_2_0_1"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="19126" checksum="35E77E5F13E5DDF9" modified="2015-03-04" version="1">MSASTSNYVLPVGQEISGKVPSISTCRESSVVLALTLLLTSGQRIPYQIDEHYLESRNVHTPGVTENGQRDPYSISIYTLKELVQREWKEEWGVQPSSPSSIRLIYFGRLLDDNMLLKNCRFNNISSNVVHMTVRPQDIGDEEDTSKSKILSKDRENREISTGCRCTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUS6</accession>
    <name>A0A0B1NUS6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005032">
        <property type="protein sequence ID" value="KHJ30127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUS6"/>
    <dbReference type="STRING" id="52586.A0A0B1NUS6"/>
    <dbReference type="HOGENOM" id="CLU_869306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079558" description="Reverse transcriptase Ty1/copia-type domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="71"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="36359" checksum="C038CD5018FB6B06" modified="2015-03-04" version="1">MITTTYILFLFSRFVVESCALTFSSALTNSIDATEVKTLNSYKEVIQSKQKLQWLQAMREEIDSLEENKVVSWVFKLKLGADGMPVRFKARWDLKGYTQQKGIDYDETYAAVTKATTLKCLMAMIAHYDLEAKKYDKMTAFLYAEIKDHEIFVEQPHGFEKTGDNICLLKKALYGLKQSPLLWFEELTSIRSTQPRTTDTNGRITQEVREYRKSNNLCMFDGGNHRTHLCTKLIEKCKKEGKPMPVDPTTLPHKVETTPKPSTSLEPALTISSLNNCQIIEVVGEIQGIAIKMLIDGAAQVNASVPRIMKLFPSKKQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVF2</accession>
    <name>A0A0B1NVF2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004561">
        <property type="protein sequence ID" value="KHJ30292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVF2"/>
    <dbReference type="STRING" id="52586.A0A0B1NVF2"/>
    <dbReference type="HOGENOM" id="CLU_002842_1_0_1"/>
    <dbReference type="OMA" id="LCTALNW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="719"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115419" checksum="BEF3549ADAD47C3F" modified="2015-03-04" version="1">MEINSRSHRKFGKQIQKLQLELPDYSASFVNYKALKKLIKKLSVNQISPFQFEVQDRSINVTSEEGLQVNKASFLFQFERELEKVNALYVQKEAELQIRLKTLLEKKKVLKSKNHITSRRFAKFTTLEEGFQQFVNDLNKLQQLVEVNGIAFSKILKKWDKISKSKTKELYISRAVEIQPFFNPTVISELSDQATTSLQELGAWSEGDYFSFDRNFDHMVSSQHLLGTDEGDTDTLLLETVKSGNLGSLKDLLSRLKNSVQSNSSRNSILRERITRTFLTAINRGPQESLQLLIDTGLVDLQSEDDINERNCLHQAAIYGNLFVLKEGLKGGVAVSRADAYGQIPLHYACMHGHLDMVETLLDSDPSTIDFIDHDRFTPLIHAIRRGHFDCVEHLILRSARIDPSSDTDHVPLNLACDYGSVSIVELLLKHGAEILSDVEGLFPQHLVARSGKTPELLLLLKQHNADLNQVDKLYSWTPLFHAASEGNVLCIRILLDVGVQLEILDEKGLSAMYYAAWEGHLDCMQLISSASICLEGIQNTHEPAQNFAFTRSSIPESASVDIDTIPELELPPPIIPLRRYGHSFLDTKTLIKISFDGDDHQPLTFFHDCKYPAARLTISSKVSDLIPKNILLPFQDDTKTITFQIDNLETFTIDFDVFPTYGAKVIAKTVALPHTFRSLMCNFGRCCLPLFDPRLRVIGQITFKFQVIKPFQGKPLEITDFQTYWKATCHLTHKPNSLVTDSSLSGDYIQLFVQQLSDGVPVLWPKGNMNHMGIEFPISCMTYEQFIYAGSRQAKTAQELTELQSWPLKGTAEVHQILSNSAISLKDALELLPRGMHVNLQILYPTSYNEKKLNFGFANSINDFCDAILSAVFDCARTIRERFPDAMRSIIFSSSNQTVCTALNWKQPNYPIFLNNDLRCESTFSDSRSSMTREIQSISVKEAVRIAKDNNFMGLFCSSSFLEMAPKLVNAIKSQGLVLLINKFDDADNVDEKPIKSSRLPEGIDGVLDKNGVLRFSEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVL5</accession>
    <name>A0A0B1NVL5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004362">
        <property type="protein sequence ID" value="KHJ30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVL5"/>
    <dbReference type="STRING" id="52586.A0A0B1NVL5"/>
    <dbReference type="HOGENOM" id="CLU_092496_1_0_1"/>
    <dbReference type="OMA" id="NSTEARG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21737" checksum="250601899CFF5F16" modified="2015-03-04" version="1">MPQPFIYINGWPGAGKHTTAKALEQRLCGKARVVHNHLHIDLAGAILPRTSPGYYELRQQLRDVFFQTLAAASETFEFIYIFTDSQTNDPIGRGVTSHFARAASDRDCAFIPVVLNCEEEENLRRLRSQERLDLAQGGKGLLLDTDLLKGFRGQGEILKWPCKELLVIDVTHKSVNEVVEKIIKHLERLNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVM5</accession>
    <name>A0A0B1NVM5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004324">
        <property type="protein sequence ID" value="KHJ30397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVM5"/>
    <dbReference type="STRING" id="52586.A0A0B1NVM5"/>
    <dbReference type="HOGENOM" id="CLU_731958_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39610" checksum="52D72CCE3BE5823A" modified="2015-03-04" version="1">MYIDGSPVLHVVDEATRFQAAKWLKNMSSQHIWEALRMCWIDVYLGPPDIINHDAGTNFTSHEFLQNAQALAIETKTAPVESANSMGIVERYHKPLRRAYEIIKEDLGTNNSLEQKAMVLQMVTKATNDTAGYDGIVPTLLVFGAFPRISNIDPPAPSIAKRAAAIRKAMLEVSKLRAKRQVTDALRTRNGPVTSDIPIGSDVLVWRVHENSWNGPYKILAINGETATVQMPHGPANFRSTNIKLYNHPTNANNELKIENTSSPINADNSRRRQPVRNAGLPTRYQDSVYLNEESKPNFSVSRRKELDGLLERGVFEFINVNDIPTGARIFKSRFVDQIKNAGTANAFEKSRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVQ1</accession>
    <name>A0A0B1NVQ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005473">
        <property type="protein sequence ID" value="KHJ30048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1NVQ1"/>
    <dbReference type="HOGENOM" id="CLU_931246_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="32922" checksum="9A6CB97DB558B8B0" modified="2015-03-04" version="1">MEITQDTQTPSTETSNPTPPIPHIPPTLNPLPLSRYLRHRQTLSYLTGLHLAEKFSNLLFLSSPGSGKEKNVEKNVAVATPKLPKPPQTSQNTWVTVARNGQKKVRVTQNNNTHTTPMSKIRLRVSTVEGASAAPTDNRLFLRLPQEHEWRKLSPAEIRKVILKKLSISPVLVGEIKPVNSGFALSPCSTEAREKILNAGNGLFLTGVKLEAATNWVTVLIPTVPAFLQKEQGVVEVSNSMLADEVERVCSVRPAHIKLYGRNKPEAPYRTWMAFFPNAEIDNSQASSVGNSTDGAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVT7</accession>
    <name>A0A0B1NVT7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">EV44_g4559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005215">
        <property type="protein sequence ID" value="KHJ30088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVT7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVT7"/>
    <dbReference type="HOGENOM" id="CLU_076902_5_0_1"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11195" checksum="04155F92A9B3ED91" modified="2015-03-04" version="1">MTDADDVNITPVSEPLDLVRLCLDEVVFVKLRGDRELKGRLHAYDSHCNLVMGDVEETVYVVEEDEQGQDILKTIHKKSEMLFIRGDSVVLISPRGPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVU6</accession>
    <name>A0A0B1NVU6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004128">
        <property type="protein sequence ID" value="KHJ30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVU6"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20309" checksum="7E1780BBBF843BCD" modified="2015-03-04" version="1">MLEGQVEVTKSMLADEIERVSTIRPTFVKPYGASNPDAPPRTWMAFFSEIPRTGFRVFDESGVTRNFNKKQQIEFCKRCNGHHNIRTCLRAPSCGNCGSTMYSQDMCMAATKCRNCGGPHLYQKAGDREYQAVVRANAAEARAFSAEQTDEVNETPDSSQIPEANAEDSNIAPVTISTGVEMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVY0</accession>
    <name>A0A0B1NVY0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative f-box wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005023">
        <property type="protein sequence ID" value="KHJ30133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVY0"/>
    <dbReference type="STRING" id="52586.A0A0B1NVY0"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_2_1"/>
    <dbReference type="OMA" id="AMVPWED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="411"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="491"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="706" mass="78157" checksum="0E9BCD64D5769C22" modified="2015-03-04" version="1">MISLYSYIFGIDDSNSATPTFTLNTMSQSTCHPSRVDKTLQPHPRGPPTPNANISSVDLYSPTHSAHDPPPPPTPAASPGPDHLQLDWSDADDQEDFFLAKIRVYFKGSSAAGRTRILADLLNLCTSQQLSFVRQYVDPLLKKDPFSCLPNEICLRILSCIDDPKVLARSSQVSQRWRELLSDDVTWKNLCAKHDYSRKLYENVISSPPQTSTRCSYPFQELLATSDYQMPLIPTAISINSFLPGSSKIFGNSIASTIRKPKPRSYKSHFKQRYLVESAWRTGGQHVARNITQDQGVVTSLHLTSKYIVVALDNAKIHVFNTDGNAQKTLVGHVMGVWAIVPWDNLLVSGGCDRDVRVWDMSTGESIHTLRGHTSTVRCLKMFDSNTAISGSRDTTLRVWDIKTGLCKKVLVGHQSSVRCLEIKGDIVVSGSYDSTAKVWSISEGRCVRTLSGHYSQIYAIAFDGDKIATGSLDTSVRIWDPHTGSCLAVLQGHTSLVGQIQMRGNTLVTGGSDGSVRVWSLEKMAPIHRLAAHDNSVTSLQFDETRVVSGGSDGRVKVWDIKTGQLVRELTAPADAVWRVAFEEEKCVVMASRSNRTMMEVWSFSPPDEILFEPDHSYSFSLTSTPAQRNFHEAPPRPQSATEFRSSNSHDQHMASIESFAINRSKAHVEWNSEDVEMLGVDSESSTSLPITAPLISATSFFRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW53</accession>
    <name>A0A0B1NW53_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004816">
        <property type="protein sequence ID" value="KHJ30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW53"/>
    <dbReference type="STRING" id="52586.A0A0B1NW53"/>
    <dbReference type="HOGENOM" id="CLU_772066_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="40504" checksum="CABAD43868F987EB" modified="2015-03-04" version="1">MSDKINYSTRTPDFSRSGRFDGSIPASRWLARLAFDLKKGDGKILPEEFLEAVEILLDGDAAMWLDSSKMFRDIIDNRQQATENDVEALKEALKAEFPIRVVERTEGNVQQEIRSFKQFPEEPLLTYYGRAKHLLRRAYGRDEPVQVNTGMVINPLSPLEKMMLSGIVSAFVEGLFDAELRSLAIRRSVMGCGSLLSAYQIVQDIKLGMETEREVEARLAKEREYLDLKALVLREFGRPASTLLAEFNSGSRLNRSEVLEQTEDADMPFRPVPAKNAFQIGTRNMRHGEKSIIGRGEPSVHKSRKVPVSSSMRPPEDTSSLPSNSVSRNPFVNGTRTYRKDKDGQLCIRCVSITIQENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWK4</accession>
    <name>A0A0B1NWK4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003680">
        <property type="protein sequence ID" value="KHJ30742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWK4"/>
    <dbReference type="STRING" id="52586.A0A0B1NWK4"/>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="28139" checksum="0492B89401F7B705" modified="2015-03-04" version="1">MIRTSALFRQRISFHTSYHFPATRILLPLTSFIRPNQSIIQTVNLKWYSTEPGTSDEQKSERNEEGEKCSEAQSTEEDPVTKDLEAKKREIIDLKDKYLRSIADFRNLQERTKRDMQAARDFAIQRFAKDLIESVDNLDRALSMVPQDQLSNPEASEDRKHLISLYEGLKMTEEVLMSTLKKNGLERFDPSIEGVKFDPNEHEATFMVPMQGKEDNTVFNTQQKGFKLHGRILRAAKVGVVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX01</accession>
    <name>A0A0B1NX01_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5961</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01003490">
        <property type="protein sequence ID" value="KHJ30882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX01"/>
    <dbReference type="STRING" id="52586.A0A0B1NX01"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="RFANFFA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="152"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="453"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="890" mass="99884" checksum="91786CC3ADA50FA7" modified="2015-03-04" version="1">MKKKHRTRLDLTQESDITHSVSVSVNSEYLEDTAVTATPNPDVCKQAIGIKRLRGGHEKPIPKAQLKSNSKCEVIPINTSTEPIISRNDDLLLNPRKFCRKKSESVSLNLVSKSAKYLLDQKEDSYRNQDGLIDVQKNRTRLPIWSKRSEICNSLQENDILLLKGDTGSGKSTQVPQFLCSQTWCKPRKVKIKINQQISNTRTVGGIIAVTQPRRVAAITLAHRVAHEMGSTLERNKHKSAGLVGYSVRFDKYIPAGMKIKFVTEGTLLQEMLQDPNLKQYSAIIVDEIHERSVDVDLIVGFLKGIVHGDKNGRGGVPLKVVIMSATLDLKEIEIFFASSKLHKTNEPGSEDSIIVRTRNDSDGKENPQFDDSKQVSVPFSKDLSNLDTAVVSESKTCDSNKKSSSGNNVKKSHDLKDLSDENGISIILVGGRQYKVDIVHEAKPTADYLVRTLQVIMDLHVKEPLPGDILVFLTGQEEIESLQTELENYSQQLVKTLPRMKIIPLHGSLSAQAQQEGFKKTKEKFTRKIVLATNIAETSVTVPGVRYVVDCGKSKVKQYRPRLGLESLLIKPISKVSAIQRAGRAGREAEGKCFRLYTEEDFNKLDENEVPEILRCDIVEAVLKMKARGIQDILAFPLMDKPNLLAIEKALIRLHLIGALDNNGDLTEIGGKIARLPLPASYGRVLTAMENKEETLILYIIDIIASLTTDTEVFIQPKTEEERESMEEFRKDIYHRQGDILTLLQTIQRYAAEETDRSEWCRKRLISIRAMKMAMQIRKQLRLICRSMNLLKAIPPPDPQPMIPISLEFAEIILKSFLIAFATNTALMAPNGNYITTEGKHIITIHPSSVLYGKKLEAIMFLEHVFTAKSYARRVSAIEAPWIVQALKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX85</accession>
    <name>A0A0B1NX85_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003915">
        <property type="protein sequence ID" value="KHJ30593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX85"/>
    <dbReference type="STRING" id="52586.A0A0B1NX85"/>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004723">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="190" mass="21370" checksum="F54A2508A1A6A464" modified="2015-03-04" version="1">MGNASSAMLESIVQGSNFDRDEVDRIRKRFMKLDKDNSGTIERDEFLSLPQISSNPLATRLIAIFDEDGGGDVDFQEFVSGLSAFSSRGNKEQKLRFAFKVYDIDRDGYIGNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDGDGKISFEEFTKMVENTDVSMSMTLGKVQFLILQKANFRYTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXA0</accession>
    <name>A0A0B1NXA0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative pre-mrna-splicing factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003352">
        <property type="protein sequence ID" value="KHJ31012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXA0"/>
    <dbReference type="STRING" id="52586.A0A0B1NXA0"/>
    <dbReference type="HOGENOM" id="CLU_013259_3_1_1"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000015">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="59423" checksum="DC67BD4D32551CF8" modified="2015-03-04" version="1">MAPSAVNGDNLISLEEIKAPEGVVLPPKEIKAILEKTAGYVSRNGILFEERIREKEKHNPKFSFLSPNDAYNAYYLWRLNEIKEGRGTAVAAGRANETAQVIEKPKGPPEPPEFHFSARMPNISAQDLEVVKLTALFVAKNGRQFMTTLSQRETGNYQFDFLRPNHTLHNFFQRLIDQYSTLLRTEGIDGTRGKQHQQRIKELEANVKDKFHCLSRAKERAEWFKFQDEQKQKKEEEAEKEKIQYAQIDWHYFVVVETVVFTEADDQANLPPPTSLSELQCASLDQKAMMSINSHNLRIEEAMPGEMDYYNSYPQQVQTTQNSTMQPGYQPGYKDSSLRVIEEENEEEQRIRERMEAQQRAQQAQAEAKGGSAPMKIKENYVPRAAARVANKQNLVVCPNCKQQMPASELDEHIRIELLDSRWKEQKAKAESRYATTNLSTQDVANNLKRLASQRSDLFDGVNGPPISEEEQARRKRAAIGYDGTPVEKGDRRLDIMQNVNVEEQIRAIHQKFGEKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXG8</accession>
    <name>A0A0B1NXG8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003266">
        <property type="protein sequence ID" value="KHJ31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NXG8"/>
    <dbReference type="HOGENOM" id="CLU_000626_1_0_1"/>
    <dbReference type="OMA" id="AVWKRAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2116" mass="235165" checksum="290D45A513F04324" modified="2015-03-04" version="1">MPRRLLQFAISQLGIIDTDVLDLENLDIAWGKNSVFEFKNVGLRLEKLENILQLPSFLNFSKANITLLRLTIPVDIYSSSLKVEIEGLQSELQVKTEERLGHKKSDIQKQNPRVEDPGKSVVETDACEKGLPNPKNLARSFLDTEPQDKKTELEAAIFSEPDDSGIWSALSYDGDDCTGVATSLALPTFMFRFLQGITDRLQVKIHNVEIILKTDTSNGDPKLSFFSENADSISLRLKIEEIDVKAVGEYSDSVDTKGEASIKESKKKDRLVHISQIQGYLEFESNLLSSLACSSTTSQSFHVDIDARDSLGQIINEIISLDSDKIEDLLKKSKYSPSDNFGEKQLNPSASPKTSRNLEIDPNNDYESVNPGNQFTPKNVCHESFLHSIGYSDKEISPDIPLTYSPTLKAASSLHSSPKNLLHCYPKFPEISAPSTSQLGKPFHKKSRSSTSSSLPTLKHSEFGASHLHDSSLESNFNDESHHTGYLVDVNIDASNDKPNDCLMKGKSPKDVFSKLNSSEEPEISKCSAYEEGSMYMSALSHKNSPDQNSAKSEETTDESIHTSTFQFKSPTPMEINIEGTPTLESGCKKYPNPKNRERIREAQKILSHPELFQNDNFSTCSISTEDSKIRASRADLKISVTDSIERNITSRCSRKILSLDNIRIYLPGIDSESTIFETAVGSTESRNSCNFDRIESSFTEIPGSFSTNKLNLNAYLRESIEIPESSSQSNFNCIKNSDGFRISIGVMRIELDTSVGKLILKLASLFADILKAQSSNNIHVLKSELIETIIKLNIEKISINLLDRLKETVTPSNLASCLVPSSGDILLKMDLIGLQIFTKITKASKNTSFSLDKFTFGYKDESILSFDSNYSMKSSVKDLKTSDGVDISAQFIQTIDTTRFEVTTLPINISINLQKLDDTFSWLGGLSSVLNLGSSIASSATAIASSPSKPRNRGVRFETPTRTEDIIVPVQNKSNIRIGGCKLDLIGSECNLMLRTSAIKIVCRDEGIGISVHKLNLSGPHLYQISNTPAITVEITNIRIEILPSPKDRDFDRLLSLITPSKSKYDQDDDILLETLLHQRGKGAVLRLTIDEFKGHVTKIEEISYFPELLEEVSKLATVAKYLPEDDSSGFLFLALIHNFELVAESGHAFGNLRLLLVNLEVALITLPALFAIGIESLSLDRNSTEKIIESVSNQELQELSIKGPVIMARIIGNEMEPIIKIKLWNLNFEYHLPTFISLIEFLENLKSSDNSNNHSTLMAASLGLGQGQKSKAYSPKNSSRKSSVNPLTIHFVFRNCTLGLNPLKLPSKLLLTLTETHLNLVFSKNDDIGVSLELKKISFLIINNVSNLASTKWALKNRKHFDDRSSQVTRLCSMGYVSIGYLSSAKVVFQMKTIDGEREVKIEVCDDLFVLESCADSTQTLIAVLGGLIPTPALPDKETKYRTEVVPMQDLFASLSVDAFGTAEGDYNFDDDFGVLEDIETCSPIDLEDNEDFDFDPQYYEKNDEIDYDETNSSSLIARETQDGILLESYLEPNELADDTELEFQENHFGASLGSEGDTNKWNSAKNTYERSEVSKLHKVPISICIRDFHVTWNLFDGYDWQSTRDTISKAVKDVTFKAIERRALNERKIISQNFDDDEDDEDESVIEDFLFNSIYIGVPANRDPRDLTSAINQDLNDTDTDSTATTNLSYQYTRSSSSKNKHIKNLHLNRSKHHKITFDFRGICIDFIAFPPGTGETQSSLDIQIHDFEIFDHIQTSTWKKFATYMQDAGQRETDSSMIHIKILNVKPVEDLAASEIVLKATLLPLRLHVDQDALDFLTRFFEFKDDSASAQPSRGEEPFIQRLEVDSIKVKLDFKPKRVDYAGIRSGHTTEFMNFLILDGADIELRHTIIYGISGFEKLGKCLNEIWMPDVKRNQLPGILAGIAPVRPLVNVGSGFRHLVIVPIREYKKDGRIIRSISKGAAVFAKTTSTELVKLGAKVAVGVQTVLQGAEDFLTPSGDSNTLDESSSASRESKKLSLYANQPFGVLQGLKGGYNGLQRDLLLARDAIIAVSGEVMESGTAVGAFKAVGKHAPTVILRPAIGVVKASGQILMGATNSLDPVNLQRAEAKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXI8</accession>
    <name>A0A0B1NXI8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative nad-dependent histone deacetylase sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6388</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003247">
        <property type="protein sequence ID" value="KHJ31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXI8"/>
    <dbReference type="STRING" id="52586.A0A0B1NXI8"/>
    <dbReference type="HOGENOM" id="CLU_023643_5_3_1"/>
    <dbReference type="OMA" id="PTHEFIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032041">
        <property type="term" value="F:histone H3K14 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141222">
        <property type="term" value="F:histone H3K4 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007654">
        <property type="entry name" value="NAD-dep_histone_deAcase_SIR2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04574">
        <property type="entry name" value="DUF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="14">
        <location>
            <begin position="156"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="489" mass="54358" checksum="B261BB4FEC290A7E" modified="2015-03-04" version="1">MDKGYHGAKKLTKHDSVKTENDALLPGEQVSSATYPPHDPDESSGDNDDIDDEGHEDDDDLSLLVDGLEELGDESLFHGAPDLCSLEDAVAFRRTLRQIGPAKFYETTIGAGKISAKKLLSAFGIRPPACMEGLPDDSYYGLLSLAISRELSKRIKLQQYNTIDDVVALLQKSKNIVVLTGAGISTSLGIPDFRSKDIGLYSKLEHLGLNDPQEVFDINIFKEDPSIFYSIAGDILPETNRFTPTHAFIYLLQQKGKLLTNYSQNIDNIETVAGILPEKLIQCHGSFATASCVDCKYQVPGDTIFDDIRAGRIPLCENCTQNIRTISLPKIMKRKRPRNSQEKRRKTNNCRTNDTSSDEDNEIPKAGVMKPDITFFGEALPDRFSARLTNHDRHLVDLVIVIGTSLKVAPVSEVVPYLPAQIPQIFISRTPVSHVNFDVDLLGDCDIVVAELCKRAGWDLNHEMVQKDQKIEVKLQDGFSSRHIFTVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYE5</accession>
    <name>A0A0B1NYE5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01003364">
        <property type="protein sequence ID" value="KHJ30998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYE5"/>
    <dbReference type="STRING" id="52586.A0A0B1NYE5"/>
    <dbReference type="HOGENOM" id="CLU_029404_7_2_1"/>
    <dbReference type="OMA" id="AYSEPQT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="419" mass="46914" checksum="F4CE7505FAEF7AC4" modified="2015-03-04" version="1">MASFLQNHQRLIILRGRNKKAFTQLISATSYYLKIRSSSYTSKEAFRQLHTSIATSLQSCETAIQHRSNFSYNIAASYVAKRNKFDSNHDFYDFKLDSKDDSYQKSLTRQQHQRLYVDDRLGTGQDAFFVSKIGKSQDIVMGIADGVGGWADSGVDPADFSHGICHYMKYVASTYEKENWNGSDLHARSLMRYGYNELCHDQFVTAGGSTACVAVARNNGTLEVANLGDSGYVLLRSNHVHSHSIPQTHSFNTPFQLSIVPREIILQTSLFGSAHFQDAPEMANITENNLMHGDVLIIGSDGLWDNLFYSDILKIVSQAMLRAQAWEFSSSSGFNVGKNLTAKVQNYHEEVNRQTRPQSLHRTIAINITSEAKAASINKTRDGPFSREVKKKLPNMYFRGGKTDDICVIVAIVCEVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZB3</accession>
    <name>A0A0B1NZB3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative virulence effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005562">
        <property type="protein sequence ID" value="KHJ30031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZB3"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21350" checksum="4DB389E4F18BB299" modified="2015-03-04" version="1">MLSSEIERVTSTRPTSVRQYGTSVPEAPHRTWMAYFDKAPHPGFRVFDESGRVTGFKKQKAIDFCRRCHGYHPTRYCSRAPSCGNCGSCMHSQSDCKAFKKCKNCGGPHRSDSYKCLARPSRYGGPTKEQLKSFRIIGEREYQAVARAKAAEQSATAVTESIIISSSQSPEPSSFDVQQTPIEASVGEQIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZI6</accession>
    <name>A0A0B1NZI6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ran-specific gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZI6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZI6"/>
    <dbReference type="HOGENOM" id="CLU_067861_0_1_1"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="28513" checksum="B3DFA1F4329012F2" modified="2015-03-04" version="1">MADSGKDVKSPEVADTASQSEDKVLAPKEEEAKNAATSTASGVADEMFSMFGGGAKKKKADEDRGDISGSAKAQKEAEKEAEKDAAKEENPEDEVPESVDVDFVPVIHLTEKVVTKTFEESEEQTFKMRAKLFKFDKEGNDWKERGTGDVRLLKHKENGITRLVMRREKTLKVCANHYIVPEMKLSPNVGSDRSWVWTAAADVSENEPEAQTLAIRFANSENANLFKEAFIKAQQENKTYFKEVQELAKSKETEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZK2</accession>
    <name>A0A0B1NZK2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004185">
        <property type="protein sequence ID" value="KHJ30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZK2"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="26764" checksum="EB55448C90542ED5" modified="2015-03-04" version="1">MALMLQDNLKSTIAQSAASDADAKMYTLRNITMAVPCIFSTTNSGSKVQNSIDPKLPPKPIANESSWSTVVQNGFKKTKTATIPASQQKIPTQPRSSGHQLDHRPVNNKMPFPTQQATRPQDKRLFIHLMDGHDWRKLLPAGIRETIVNKLAILPSAIGSIKPVRSGFALSPCTNEAREALLNAAIRLSPFGAKLESATNWTSVLIPTVPKSLHTLNGHVEVTKELLSQEIERNQNAPLFFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZP3</accession>
    <name>A0A0B1NZP3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002568">
        <property type="protein sequence ID" value="KHJ31812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZP3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZP3"/>
    <dbReference type="HOGENOM" id="CLU_058482_0_0_1"/>
    <dbReference type="OMA" id="HIQWADT"/>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="28687" checksum="559C83E2F739F7FB" modified="2015-03-04" version="1">MSKVSSFSPMSSRQQTITQTYSLAHMARRKLAREASRPDLHLPRLVGHANLLDSLMLELGRAEREQQQKQQPVNVTVQRVSKSDTSRHVQWADCVVVESEEDWNLSDAESDNDEEELDSDEFPDMEANMVSLQRVPSHRNLSTMTTQNVFSCASLMSYSDDDVDEDFDVLQLEYSPSHCPPELDNDSDSSEDEAMPPSPPLNHSPSFLSTNSAPQNLQKPVTEDNLTSNILDFEKTYFNPSHTHTENIPTISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E2</accession>
    <name>A0A0B1P0E2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5531</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01004398">
        <property type="protein sequence ID" value="KHJ30356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0E2"/>
    <dbReference type="HOGENOM" id="CLU_004962_6_3_1"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ30356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="586" mass="67034" checksum="B89BE5427DD0F1A0" modified="2015-03-04" version="1">MASTDDMEKNAQGSIARAQVDNALRAIHHKKPIPEIDFTLHTMEDGSQVSTLERVCKDVQAPAMFPPTDEQFFSNEDPKKPNLPFLKQHLYREGRLTEEQALYIIEEGTKILKQEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPAETRYLFLGDYVDRGYFSVDCVLYLWSLKIWFPNTLWLLRGNHECRHLTDYFTFKLECKHKYSEKIYEACMESFCALPLAAVMNKQFLCIHGGLSPELHTLEDFKQIDRFREPPTHGLMCDLLWADPLEEFGQEKTSEYFIHNHVRGCSYFFSYPAACNFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILSTCSEDELKEDLTPTAISPYNPILSPTSPIDPDSIEYKRRAIKNKILAIGRLSRVFQVLREESEKVTEFKTASGGRLPAGTLMLGAEGIKDAITGFEDARKVDLKNERLPPSLEEITRTSEEDRALALERAKESADNDRGLQILSRRLSLVGTQPNRPQPSKILNSVLALDKDVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0G8</accession>
    <name>A0A0B1P0G8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002285">
        <property type="protein sequence ID" value="KHJ32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0G8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0G8"/>
    <dbReference type="HOGENOM" id="CLU_105984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="222" mass="25253" checksum="0888B9DDC5A9C4C4" modified="2015-03-04" version="1">MTSYILNSNNFLVITVKHGCLAHVFHNIDGITPILRPVLPARVPDQDDEDYKKLEAEYQTNLTKWVEGEIQDKNMLIKRMILTVRPQSVRIMTAKQLFDHVAASREEGATVPYETAVRNLHNAKFVTNAEDYCDEFMQNYLSVNNAAESIQSRSPKGDSIVNPFSILPGYASSFFVLGTEKIEWLDTWRHTKIFDSSNHYVPLEVMMATLRQVATGREQSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0U7</accession>
    <name>A0A0B1P0U7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004022">
        <property type="protein sequence ID" value="KHJ30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0U7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0U7"/>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="214"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="836"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="985"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128929" checksum="AEAA0D0E4B1E967F" modified="2015-03-04" version="1">MAPIGPAPIIMETTVMSKTKELKGTEKRDSLISFEKKYQVEWQTKGIFQANAPSISQTPLHSISPAELRVQYPKFYGTMAYPYMNGTLHAGHSFTVSKIEFAVGFARMQGKRSLFPMGFHCTGMPIKASADKLAAEVAIFGKKFENYKDEEVEIVLKDQTKSDSRREDVTKFTAKKGKAATKAVRMKYQFQIMQAIGIPTEEIHQFAEADHWLDYFPPLCQRDLTNFGSRIDWRRSMVTTDANPFYDAFVRWQMNRLKELKKIKFGKRYTIYSPKDGQPCMDHDRSEGEAVGPQEYTALKLKVLDWAPEAKKIIEGKIPEDADTYFVPATLRPETMYGQTCCFVGPNIIYGIFRLSSKEFFIVTERAARNMAYQGIFPENGVYEKVGELIGTTCVGTLVHAPLSLHKDGVRILPMESVLSTKGTGVVTSVPSDSPDDFATVTDLCKKAEYYGIKKEWVELEILPIIRTPTYGDRTAEYLVKKFKILSPKDTKKLEEAKELAYKEGYYQGIMLRGDYAGEKVEVAKPKVKQQLIASGEGFAYSEPERKVVSRSGDECCVALMDQWYIDYGEESWKQIALRHVGNTDGAGMNTFAQETKNGLEGTLNWLNQWACARSYGLGSKLPWDPQFLVESLSDSTIYMAYYTIAHYLHSDIFGKSPGLANIKPDQMTDEVFDYIFARRDLTESILLESKIKEEVLASMRREFEYWYPLDVRISGKDLIPNHLTFFLYIHLAIFPKEYWPRGIRANGHLLLNGEKMAKSTGNFMTLDDMLKKYGADATRIALADAGDGVTDANFEEDVADNNILRLFTLREWIQEQVKSASSLRDGAKNDFLDALFENEMNTIVCQARQHYEDTNYKLALKSALYDFTSARDFYREYSAAAGVKMHRDLIFKYIELQALLLCVIAPHWAEYIWLEVLHKPCTIQNALFPTVPAPNAALNAEREYVRATGGNVTSAEAAQQKKKSKGRDIGYDPSKPKKLTIYCADSWPAWQEKYIKLVKSHWDLKKKCMLIDDKELNRQVTLMNEIKTNKKVMPFVQSLKKRLITGVEDEIQIFERKLPFDEVQTLQNMVSGLKKAASLAVIEIIRVSSSDGGKSGLVVSVGDSLMNHYDVRKIENLPILAQSAVPGIPTFGFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P128</accession>
    <name>A0A0B1P128_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ubiquitin ligase subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003362">
        <property type="protein sequence ID" value="KHJ31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P128"/>
    <dbReference type="STRING" id="52586.A0A0B1P128"/>
    <dbReference type="HOGENOM" id="CLU_004747_7_0_1"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="432"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="815" mass="94475" checksum="B7DD2C603CE7561A" modified="2015-03-04" version="1">MSCYKHTDAFSSYPSMNKNKNNLTSVNPRTTEGIDLTRPLSFQPSTGSKRLEIKNLRTKSRRGTAEYYEKIKKDIDSALTSIFANEHPKSPFETLCRGVELLCRRGCAEELFKRYHERIKFYLEKVMLPQIEEETKSLHAETLRTVYKYWMEWNKQSTLLRSIYCYLDRSLLLNSKEYPRMEDLNIQQFRSIVFTKGKSANDQRLGEKVISNICDLVNYKRTRQLEVFDSALLRQSIQMLHIFGIYSKLFEPEFLERSREFFLTFTASHSNAGIKQYIHACDKVLAQEILCCDTFNFDSTTKKSLLDLVHQYLIIGCTEILLDESEIAKLIDENSMSTLKILYKLLSISGIQGKLKAPFINYIKEKGSQIVCNVEKVEEMIIRLLELKKLLEKIIRDTFNNDETFFFSLRESFSDFMNDNKVLVVWGTRSSKVGEKIAKYMDMLLRGGLKAVPQSLISNTYGSKSSEKQEYSDTRDEDAELDRQLEHALDLFRFVEGKDLFEAFYKKDLARRLLMGRSASYDAERNMLAKLKNECGFTFTHNLEQMFKDQEISRDEMFAYRQSLSNSGGGKPRLDLHVNVLCAAAWPSYPDVKVNLPPEVAKQIESFDSFYIKKHSGRRLAWKHFLAHSVVKAKFNKGYKELLVSAFQAIVLVLFNDVESTEPLSYTTIQHATGLADVDLERTLQSLACAKFRVLTKHPKGRDVHHTDTFTVNLNFSDPKYKIKINQIQLKETKEENKETHDRVMQDRQYETQAAIVRIMKSRKAITHSNLISEVIEQTKKRGSVEISQIKSNIDRLIDKEYLERVNGGSYVYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P146</accession>
    <name>A0A0B1P146_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004011">
        <property type="protein sequence ID" value="KHJ30549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P146"/>
    <dbReference type="STRING" id="52586.A0A0B1P146"/>
    <dbReference type="HOGENOM" id="CLU_013933_3_1_1"/>
    <dbReference type="OMA" id="VHQLNNA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="595" mass="67451" checksum="A7A36E20C5747EC9" modified="2015-03-04" version="1">MDLIQAVSGYISKMVSEVDNVSGTMSTKMKILLLDRDTVSIISTAVTQSKLLNHEVYLVDRLDNHKREKMRHLRCLCFVRPSPDSIQLLIDELREPKYSEYYIYFSNIIKKSSLERLAEADDHEVVKVVHEYFADFIVINPDLFSLELSPPSRIWSANADTWNMDTLQRTTEGLLAALLSLKKKPLIRYQKNSLMTKKLATEVQYFINQESQLFDFRAFDTPPILLILDRRDDPVTPLLTQWTYQAMVHELLGIKNGRVDLSEVPDIRPELKQVVLSQDQDPFFKKNMYLNFGDLGGNIKDYVEQYQSRTKNSSNIDSIADMKRFIEEYPEFRKLSGNVSKHVTIVGELNRKVVAENLLEVSEVEQSLACNDNHAADLKNLQRLIQSPNVTSDAKLRLVALYSLRYEKHPSNALAILVNLLVAAGNFPRNRVDIIPKLLTYQASLQQNQATTSGISNILESTGIFSGARDRLKGLQGVENVYTQHSPRLELTLQNLIKGRLRETQFPFIDGGGTTRDKPQDIIIFFIGGVTFEEAKTVSQINASSLGVRIVLGGTTVHNSTLFLTEVEDTVSKWPESEPTTAAARLQKEINKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P181</accession>
    <name>A0A0B1P181_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01002132">
        <property type="protein sequence ID" value="KHJ32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P181"/>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="11">
        <location>
            <begin position="714"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="12">
        <location>
            <begin position="906"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1232"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1360"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1392" mass="159561" checksum="92110BEBB3BA1041" modified="2015-03-04" version="1">MGVPKFFRWMSERYPAISQLITENRIPEFDCLYLDMNGIIHNCTHKDTDDTSFRMTEEQMFITIFNYIEHLYGKIKPKQLFFMAIDGVAPRAKMNQQRARRFRTALDVELAINKAIKEGKEIPKEQAFDSNSITPGTAFMHKLTRQLKYFISKKVSDDANWKNVKIILSGHEVPGEGEHKIMEYIRLAKAQPDYDPNVRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRASKSKSKELEYQKFYLMHLCIVREYLELEFQELKKPGALKFDFDLENVIDDFILMAFFVGNDFLPNLPNLHINEGALALMFKIYKIILPKIDGYINEGGFINMERLAILLDELSHVEYRFFESDVADQAWFDSKLMSRRDVMLKGKSLDQVTMTSYQQENWKNIKSFLTDKSRQQIDLPLDLAAIDKSFFETLATRINLKWRSVQDEDGNRHMQLYRSSPSESDNTEIENLESEITSSIKLYDDAKIVDVSVVETKAQMDLLYEEKFRQWKDTYYQSKFEWGLSNNFELVRLCENYVQGLQWVLFYYYRGVASWAWYYQYHYSPMISDVIKGLNADLNFELGKPFHPFEQLMGVLPDRSKEIVPAVYHDLMTSSKSPIIDFYPRDFELDMNGKKMEWEAVVKIPFIDEKRLLAAMAPRNHLLSNEEKSRNKFGVTLQFFYDSSVNYTFPSSLIGIFPDIPYCHCVEKEFYLPVVEGLEYHVGLVDGVKLRDAALAGFPSLSTLPYSSALDFHGVNIFQSESRNESMIITLKDLESRANIETALMKLGQKVFVGYPYLQEGKVVKVSDEHFDYLPSNDGIAKPIQRPHNPREIEDFNKKADRIEYNYSNYLGIVIGPVKSTVHVEMLEGLTKTDEGATIKKYAVIPGMETEFATQVIVHDVINEDQRFLEQAALPIEDEFPPGTRAFFLGEFDYGRPLEIIGHDKDRTEIWLSATVAKEQDFGHQVIQDYGSKIKYTSAFAVSQMLGLNSLVLSKITSSFSVETPNSSRINLGLNLKFESKKQKVLGYTQKLDKGWEYSNKAIELLTTYMTKFPEFFVGLHRCIRASEYKTTDFYPSETADEKIKEITEWLKSIESKNFERVPLDSEQLDPEIVTAIEQAADRMLQTFPGVAYKKLRGVPRYALLKPSDAEHRLGHQSFSLGDRIVYVQDSGRVPIATRGVVVGISRTSRTALLDVVFDLTFMSGTTLGGRCTPFRGSTVPTSSVINLSNKQVIAETRIPNGRHSESNTGTRYRHNTTYPTRGGGSFNRNAVLSPPRRGTYRGAILGNNQDSNFQSSSNMSEQNRDRRPSYENQWSPITRGNLPIRGGSPRQRYQLRGGRNHTHSGNDFGWPTSDLTKNYNAVAPTIIDSTRGARGGSWGRDRAGPRFSRGRGNHHPAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B4</accession>
    <name>A0A0B1P1B4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ring finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003871">
        <property type="protein sequence ID" value="KHJ30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B4"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B4"/>
    <dbReference type="HOGENOM" id="CLU_026793_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="626" mass="70969" checksum="1B7063E2673DB88C" modified="2015-03-04" version="1">MSDIARLKTPVEPENISESLRLPRRCWVCQQEDTDDTPGNDVWRTPCPCSLTAHDTCLLEWISNEEAPRPGDIARSRLIRCPQCRAEIKIQRPRDYLVIVFEAIQRITNAMVLPGAAASLIMCTYAGLLVYGMNTIKIVFGNEDALKIMKASTIQTENIWGTTRILANIIKQFDPLLPSTYPLDFLKVFIGTPLIAPSLIILRTRWAHRAFSFLLPLHFMNPANQKISWPPPPGLVFATLPYLKTAYNELHRYLFGRLESNWDMAVQRKPRAGETREEIAFEAEREDTEGFLEIRLALTEENDVRIPEQGGNLPTDVGRAQQLHQLNLPQVQIPIENIQEQAERLNNNEVANARNEGSNSLPLPNDSQNNDNEDGPNLVQLEEPDFVVPRRNDHHANAERNAGRNIPPNDDRTVVHHYHASQLISLVIGALSFPTVAALAGDILKYTLPSSLVTPQLTYSWGIRSFKRGILTEKWGRTVVGGCLFVLLRDAVILYCKWKKAREFGKRVVVDYVKPRSNSSGKEIFSAKTMLFHDRNNRILSSASLIDGFYKLDHIASSSERALWSGAFTSTSKNLMPMSIDHIPKEKFDEIIDDGKPIYSQAGILEKTRNKRRKFFSVKQRLLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1G7</accession>
    <name>A0A0B1P1G7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003222">
        <property type="protein sequence ID" value="KHJ31135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1G7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1G7"/>
    <dbReference type="HOGENOM" id="CLU_023703_0_0_1"/>
    <dbReference type="OMA" id="PNDKEWM"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="51288" checksum="13AF036E584FDDD5" modified="2015-03-04" version="1">MPFPFVLPTTRSFSFTSFFTCDSHPSLPLTASTYRGVFRDTLKKYKRLSPAEQVAYLPTVFSSLNDYIPYLFAIDQGLSNQILSGQLVSIVLQSTPTLEWRPTLSDSLLPGRRISKIKVESLEYEIYFTLSTLAYTHTLLAQTSLNPLYSLDSALPSLEQRTLIISTASKHLLSAASIHEYLSVCCEQILIPSPCVDLSQYTFKALASLALAEATLLVVLKDDPYPFIIAQERNKCDKEWMIKPPEMPKVRANLLARLCLAAAEHASKGLSILSNASSDGKGKINHDLLKYMEEFKSTSQGKACRFLGIGAELNGQIGTAIAWLQAGMYQLGMSAEDTKMRGLKRLKKDWEGKKLEKKSQWGADAGKLEELRILDLLEYKWSKENDTINAQPIPPVGPLIAMMPSGREIHSLKPFIPPVIEASILESLKSSDSSDELAEESESVDSKACSEIQSNYSCGGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M4</accession>
    <name>A0A0B1P1M4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001996">
        <property type="protein sequence ID" value="KHJ32542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M4"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="135" mass="15084" checksum="A0652668A2BBFB4C" modified="2015-03-04" version="1">MHSEDLCMAPTKCRNFGGPHRPDSRKCLARPTRNGAPTKEQLKIIRQAGDREFQAVLRAKAAEERASVLEGNSDEEPSQPEVVDMENTQASSVEDTAGDALRLRRTPHRVTFPLTLYLDSCQLMLEEGAQHRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M6</accession>
    <name>A0A0B1P1M6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytoskeleton organization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003703">
        <property type="protein sequence ID" value="KHJ30724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1M6"/>
    <dbReference type="HOGENOM" id="CLU_012285_0_0_1"/>
    <dbReference type="OMA" id="WKRREHQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="984" mass="113286" checksum="1310E497C6467F92" modified="2015-03-04" version="1">MQSVSDRLYISIWNAISVKNFKQARKIIDKKLSKCPDHYLEALKLYLHGKTSSFAEKLSILAQLEELAGRDPFISNPDTIDLYEEILIETLPRSTEIWAKTIGELRWKCVKLSPSDENLCLHALMTCLSNDDLDHARQIVNVTEKKFSKNRNYVFWNITIMSLFALSDCYPNEKRNLCRSLALAQILKIADSTILSSAQGTLPLRSIQTPQEILLLHKIIDLSGSLEKSIVYLEDPKLGPESPIAKGGWELWRLKLKRLSQLKMWDELFKTAISLLERARTKNAMGKLLESSFSDWLVWDSLILSAAEFTDQTYMKRIKSELEAHLDPNSGVEKCWRRNASLAYVKFNFQTCIPFSNDTGKLKDNLFSLETIALIKYLYEYGDTYTVYDDLRPFLEVLRLSERIKFTNLLTSSVEPKDSECDDEHKKSLTLMIEKILSNDFSSSSGMLRASNNLKFKYLLTCSIPERKNYKNLLLEKPSLSPLKQIFGEAITLYKTAIKISNNVAHNLLKTDRHPIDDMALVASMCLVKIGLQEKRYEDEFLNNNKFSHILQAALILEFALTKSKHNFQILILLLRLYSYLGCGSLSMSIYQRLAIKQIQMDTLSYTFFDRISTFHPHPFENFPDEVTDTRSPAEHLRRQQKFYQEVTGQISANIKSSFQYGSYNSIFEMTEVSDSLKHSISAVSCLIEDRKISRLLAPSNYLEALPKNYEDIPLLSTPKLSDNNDYLTFPSFESSQSQSFHDICNFLAPPSVDRMKSLVLRDNIYQILLIHSDIKNSKYAIHRKWLERYYIQANTSTIDTDSMTRSEALAYDICHSLALITYISCESTCWLEEDFDRCLDRYNTNLLNAIESQRSLVSILKSYAIPSQITLHVLYTAYDVGNLCLEFHKYILSFQNTTHKSQIKNNEKILQEAVSLLSDVDQKAGKIRKSLNEAGWIDRVLNIFNDEVKETVNENFMEEWAGLVVESWRDSTIGLSYLKKQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S9</accession>
    <name>A0A0B1P1S9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative f-box wd-40 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001954">
        <property type="protein sequence ID" value="KHJ32607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1S9"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_0_1"/>
    <dbReference type="OMA" id="HSKGIAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="292"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="498"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="869" mass="97632" checksum="3DC0098EBBBE6012" modified="2015-03-04" version="1">MRKSLNSLNNQNLLDEGYCEDPLNVRSLLSAPLPEWLLQLSVTERTGYVINIISHLPTSQVAEIENHLRPRLYINFFEHLPNEVLLLILSFLDPISLLSTARVSRQWMSLALDSRLWKQLYLREGFRVIGSEVDIFEKGLNQIIDGSRDLDIDLFGNSIESPISHNMSRQTKAKPETIVCDQVKLKESLPGSKLREGNAQREGNLYDLIGTSSGLSNSTLDQMSQNYLRKPASIGFILNPNISSLFVLDHHSNQTKYKLNWQYLYSQRRRLEANWQLEKYVNFQLPNPNHPEEAHNECIYTIQYSGKYLVSGSRDKTIRIWNLETRRLVRPPLRAHSGSVLCLQFDADPKEDLIVSGSSDATIVLWKFSTGKIIQRLRTAHKESVLNVQFDKRILVTCSKDRTIKIFNRSPMYIGNSNYSADAQTVNPVPKILNNYGFSLSSTSGVLIKPAYSLIATLEGHVAAVNAVQIHGNEIVSASGDRLIKVWNWPEQTCVRTLVGHTKGIACVQYDGRRIVSGSSDNEVKVFDKETGLEVASLRGHSNLVRTVQAGFGDLPFSSEADITDKKVADYDYFKAHGSARISDIGISGEKQPQGLTSRQPENVTALGTKLQSGGGGGKFGRIVSGSYDETIIIWRRDKEGIWKSQHILRQEEAAKAALRNTQVHSESPEIFVQRIFYNQLIKDAVIKGPSALRYALAAYPQALHYQEYLKNQISNSCQNTQQAMQMIVAEAISSNQVISQLHLPTDQLSNDQRCSPNSIQPTQRFHFATSETRTNLHMAATQTSTSLTNNTPSYGSTTNHSLVNQTSTQNVHNLPNQPINGEITRVFKLQFDARRIVCCSQTNAIVGWDFANNDQKIMEASRFFAPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X7</accession>
    <name>A0A0B1P1X7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcription initiation protein spt5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003476">
        <property type="protein sequence ID" value="KHJ30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1X7"/>
    <dbReference type="HOGENOM" id="CLU_027502_0_0_1"/>
    <dbReference type="OMA" id="YLRWWFL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="544" mass="63232" checksum="42BD931CCC8F940B" modified="2015-03-04" version="1">MIGTSKFEYFYIRFFIVILHLIAPLCLAYCLSLLLFYGPIKLVSSPFSLYAFAESLFLVAYFPYRSYLQRDATDIPTTDPQKRKELFDRCRNNIPDPELYIRTWFLGAELAEIKRDNLKDFILWAFFNREGPPGEDDDELNAYIEQMESKLGRKFEEGRGNAVSIRLTFDKVKMLHRSMFWYLCVGFVDSLTHIIMHYHGFDFYREDHGRFLSTFPFRPLTLLSSLKSPVKKTAYWYRKHKSNDLLPVVFLHGIGIGLYPYTPFLKELNQLKKVGFSRTDEQIGIIAIENLNISFRLRDAPANSKDTCSEIEQIILNHFPPNQQFVFVAHSFGTNVVSLLLKNPATAKYINSIVLIDPIPILLHLPTVAYNFTRKTPSKANEHQLFYFATMDMGIARTLGRHFHWSEVILWKEDLGNRNTTVSLCGQDLIVDTVSVGRYLSTSYAGEYIIPGLDENYAHPEEKKFPNNTFKTPMDNDVRKVGTKENLYLEPLNDEWKFRSWIGTGIDILWFGNLDHAQIFDKYSTRRSLLNVIRTYCRDGCSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P264</accession>
    <name>A0A0B1P264_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sda1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002904">
        <property type="protein sequence ID" value="KHJ31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P264"/>
    <dbReference type="STRING" id="52586.A0A0B1P264"/>
    <dbReference type="HOGENOM" id="CLU_970420_0_0_1"/>
    <dbReference type="OMA" id="WCHENIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="33498" checksum="CE0B4F176688B4DB" modified="2015-03-04" version="1">MDETGARIGCPTREAVVVPAHVHELHNGSPENRLSITVIETNSAGGNYQPPFIILPGEKLKDNWCHENIENDTWVTTSPTGYISSQAMLEYLKHFVKFSDLGQNKPWTILLIDRHKCHYHEEFFLIAEENHIHLQIFPSHETHALQPLDFGIFRQWKHQQNRYINMAIRQYNFNCKKALRTRARYKGQIHRYNDRVQRQRIRKRKEAEAELDEPELSRQLELLHPRPTTNLEAAKIIEEICKRDTLEPPSFPGAYKESLSIAHDLLIKADLQADTLQNYESAMMAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2F8</accession>
    <name>A0A0B1P2F8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g3487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01003588">
        <property type="protein sequence ID" value="KHJ30809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P2F8"/>
    <dbReference type="HOGENOM" id="CLU_000335_0_4_1"/>
    <dbReference type="OMA" id="CHANINT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="223"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="437"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1366" mass="155961" checksum="A74FF78A7AE1C8BE" modified="2015-03-04" version="1">MPQSVYHEGNPCRIISNSENNLRFKQHLREGTNLHGIQEKIFESNPDALTQLANAMLLHQPLQNIRSIKSNFELPSIDMTKFQANSPNVPQRYHIPAFFKSQSSFQTPGSKSASATSSSSFAGISSSPTARLSFRREYNRPIESNCYQSNNQRSSKDSDSLELQNSNHYPNVLSNTNPKCLALKHAPLMAQGIQLISPDGLPERIRQVFPYEYFNAVQSKCFGTIHNTDDNLVVSAPTGSGKTVLFELAICRIVEICPSEQFKIVYLAPTKSLCSQRARDWQKKFSHLNLSCAELTGDTNKSEMTRVRNASIIVTTPEKWDSITRKWTDHYRLVQLVKLFLIDEVHILKDPRGATLEAVVSRMKAVGARIRFIALSATVPNSEDIAAWLSRDYSNQHLPAYREDFGEEFRPVKLEKYVHGYDGSFNDYAFDKFLDGKLISLLQKYTHRKPTMIFCFTRKSCEATALMLSEWWTRQGAADRVWSSPFQKVIVGNMELQKVVVCGIAFHHAGLDSQDRHAIEDGYLKGAISIICCTSTLAVGVNLPCHIVVLKGTVGFQDGILREYSDLEVMQMLGRAGRPQFDDSAIAIIMTRTSKTKHYNQMISGQDTLESTLHLNLIEHLNSEISLGSVKDLYQARTWITKTFLSVRMRKNPEHYRITDITEGGNTDERLEKVCERDIKLLQAHNLVTNEERFACTEYGEAMCRYMVRFETMKTLLSIPEKASLEQILKIICHATEFKDLRMKPAERTCLKKLNQSPFVKFPINESVITSAHKVFLIIQIQLGGVQCPDEKEFGVFRRQFLIDKRIIFERIHRLIRCVIDCKAFDRDAVSTRNALDLARGLSAEYWEKSNLQLRQVPQIGPVAHRKLCHANINTVEKFGALDTASIERILSKNPPYGKKMKDILASFPRLKISATIIKKILMGIKNKPQIHMRAILNYENDNVPIWNHRKPAVVFIAESSGGELSHIWRGNINNLEKGYELKFTVTLSRVEEEIRCWVACEDIVGTLKYCVLQHGIPATCFPPATSGIEAQNKNRPKDEIFDNSDEFGIDELGDEEVLALATSIEKPVYEHQSDDFTDVNLFDSDTQSIMSNPRNVQMNYNFKEPVESTRMKNGKWTCQHDCRNGGLRKNGQRYTLKGVEIIDLTNDLSDSSLINFTNDKITPISREDYESSMRHETVFSTISDIGTDEMSELSIMFDENHNLDYSIPESPLQSTSLEDSKIFFSSNQDRFENDSTEFPYINEEKGKILNSEFNNKIYNTVEENQFSSPKLKNSDELGKDKNMTQENNIKKRISTTSSGDEELFNPKRKRSLSPEDIEATQFFYKDFDQVSRRSFHKSPRLVPDWVKEFDSDLIDELKEYVDFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2K9</accession>
    <name>A0A0B1P2K9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01003494">
        <property type="protein sequence ID" value="KHJ30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2K9"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="OMA" id="IGELFCK"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="52586" checksum="F8209B7071C97D8D" modified="2015-03-04" version="1">MDKSAFKLKDSSLLKTNVAFVNGEWVSSKSGKTFNVFDPASGNLIGQVPEFDKEDTEAAIKAAADALPTFRAKTGRERSKILRKWYDLMVENASDIAQIITLENGKPLAEASGEVAYAANFLEWFSEEAPRAYGDTIPASFTGNMIAVVKEPVGVCGLITPWNFPAAMLTRKIGPALASGCTVVAKSPGETPLTALALVELGRRAGIPKGVFNVISALENTSIVGETITTSSIIRKVSFTGSTSVGKLLMKQCSSGLKKLSLELGGNAPFIVFGDADIDLAVAGAVSSKFRSSGQTCVCANRIFIHSSIYDSFAVKLAAKVAQFHVGGGFTKGVTHGPLIHEKAVAKVEAHVRDAEKKGATIIQGGRQMSELGPNFYEPTVITGMTSNMILASEETFGPVAALFKFDSEDLVVKIANSSPVGLAAYIFTKDLQRAMRVSNAMDVGMVGINTGIISDPCSPFGGVKESGFGREGSKYGMEEYQVIKTMTFGRAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2U7</accession>
    <name>A0A0B1P2U7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002695">
        <property type="protein sequence ID" value="KHJ31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2U7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2U7"/>
    <dbReference type="HOGENOM" id="CLU_1379045_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22411" checksum="86EA9DB2B85A22B6" modified="2015-03-04" version="1">MRLSYAHVDSIPVVVFSGTIKSNLFTKSLNIAKYSNLLLSNHENRRSLSLTSTSYSDRTQYSLIRQSAYGIIPSKIDFPIVKLYQRRWFQPCCLKDSSSRSITDSDDSSLSSAVSLLVPPEHLNAEEKKIYEHLVQELEPTFLDVQDISGGCGSTYAIEIVSYRFSGLTLVKQQKLVYVALRDMIKEWHGVRIKTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P348</accession>
    <name>A0A0B1P348_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative snf2 family n-terminal domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002620">
        <property type="protein sequence ID" value="KHJ31740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P348"/>
    <dbReference type="STRING" id="52586.A0A0B1P348"/>
    <dbReference type="HOGENOM" id="CLU_000315_10_1_1"/>
    <dbReference type="OMA" id="KCQTHEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000035">
        <property type="entry name" value="DsDNA-dependent ATPase (Rad54b)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="300"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="623"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="936" mass="104468" checksum="EA7E40FEF1BB630A" modified="2015-03-04" version="1">MFKPFKPPLLKKHPQSTYQSKEDEKILESPPNRKISTSPIRPVSGAADNHSSSEVPAQEVSDVFSKKINKPKLFSENAEGYYLVLWRNFTTKKHKTWDGDGVLSIYGGFARLQDISGKDIGKTAFKDPLLPGSCLSVGGKEIEVDSIITKADFEAGKPFIQSPSKRKSSFSDSNSLVPKRPCTTISVSKNTLALDCHKVNSLKAEIPVKSFYAHKSNQSLAISANFKSPLMPNLLKSKGKAPIVTPRHDPNVPGAVVMKRPTEVPQGKEIIDVVIDPFLSQHLRDHQKEGVKFLYECIMGFRDFNGNGAILADEMGLGKSLTTIALLWTLLKQSPFQGCARIIQKALIVCPVTLIGNWKKEFLKWLGNERIGVFIMDGRRNKITDFTHGKSYSVMIVGYEKLRSIQEELKKGIGVDIVIADEGHRLKTAQNKSAQAIRSLSTPRKIILSGTPIQNDLSEFFEMVDFVNPGLLGTYKAFTKEFEIPIMKSRQPEASKKDIKLGTARHKELSSLTQVFILRRTSEILTKYLPSRTEYIIFCKPTEVQVKVYQHVLASPSFGNILGSPEASLQLITLLKKVCNAPSLLANKITNLSVNSKVSELLDVIPIKLLQIPPSIASAKLRVLDQLLNQLSQCTPEKIVIVSNYTSTLDLLSQHLTSKSLPYLRLDGKTPTSKRQDLVETFNKTPASKSFAFLLSAKAGGAGLNLIGASRLVLFDVDWNPATDLQAMARIHRDGQKRPVKIYRFLLRGGIDEKIYQRQTNKMGLAESVVDGKKNDSSFSYQELRDLFRLDLNSKCQTHDLLDCGCKGYGTNSLPEPNICENSIDNSLSITSEDDDSDLVYPIVNKIVPGTRANVDAIEQELVDKIEKNRSEKSKNKMQALMLYQHFDASLFQEKDNFCYQEKENSTTLYNKLGDDILAKTLIEQTNIAYIFSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W0</accession>
    <name>A0A0B1P3W0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcription factor far1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002992">
        <property type="protein sequence ID" value="KHJ31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W0"/>
    <dbReference type="HOGENOM" id="CLU_1571774_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="170" mass="20099" checksum="5D575FCEF39B087E" modified="2015-03-04" version="1">MLAPPERYYEGELLDRACSDCQSFARSHGYHLSRAPGSDKGKGRIYLQCHRAGEHETRGTVRNSQSNRIGCPFRIRIRYFKNENKTRVIHEYTQHNHEASVDAYTAQIYHYCSPQEREFIRHRRCMGDQPRQALDNLMRRFPNTQLQYHDIRNEFSAAHVEETRLYGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Y0</accession>
    <name>A0A0B1P3Y0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002382">
        <property type="protein sequence ID" value="KHJ32050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Y0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Y0"/>
    <dbReference type="HOGENOM" id="CLU_081911_0_0_1"/>
    <dbReference type="OMA" id="CFALGIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22025" checksum="DA3356869187F5CA" modified="2015-03-04" version="1">MFGIFFVFWRLLEILTLIPTMGMLAFFVNLYARANALTPTYVLCLFIVSVLALAWAIATLFTYHRSATNAHFVAIVDLFFLGAFIAAVHALRGIASQNCTSIKSSSAYSISFGIIGKATLNRFNFRANRQCALLKASFAFGIMNCLFFAITSALAAIHAFTQSDRDVYVRDTHSSRHTHQRSQSERSRRASRRSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P485</accession>
    <name>A0A0B1P485_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative nucleoporin sonb protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002297">
        <property type="protein sequence ID" value="KHJ32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P485"/>
    <dbReference type="HOGENOM" id="CLU_002330_0_0_1"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="843"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="762"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="464"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1880" mass="202424" checksum="AAE1147574AB6B85" modified="2015-03-04" version="1">MSGFGAFGGFGQNTSNNSQTGTTGFGAFGSGTSTNTGFGTPNTGFGSTGFGNTNAFGSAATTNAFGTAKPSAFGTPAVSGGLFGNNNTTGSTFGSGAFGSSATPAPTFGSNTNGAGIFGGATSTPFGGTASTTTSSAFGAPASTTIAQTGLMECQGTGNVAFQAYVEKEPNSTTNQQNSFQNIAFQTPYQKFSMEELRLADYNQGRRFGNASNQPGAFGQTNFGGFGTNNTGFGTTTNTTGGNMFGSVATSSPFGTNTQANSGFGAATTNSGTGLFGAKPATGGIFGSTQPSSGLFGNSSNTGFGGSNTNLFNSANTGGSLFGQNATPKPAFSFASPTTNNSTNAFGTSSTTGLFGNTGGFGNSNQQQPASTGFGSQTATPNAFGGFGTNNLQPGTSSLFGNNQSKPTGGLFGAPSTTTNSTGLFGSAQTAPTTNLFGASNTTQNSGGLFGNKPAATGTDNIFGNSNNNQTNTSGNMFGSFGNQNQQQSNSLFGGNNNNSFQQKPSIFGTSQAGGVNSPFSNTGTQQQNSLFGGFNNNQSQQLQQNNSSIFGSNNSPFSNQNQKAPQSLTASIGDNTAYGLQSLFSDIATNQVNNPGPIATPLSGHRNSIGPKSAALPLYKLNSGSASRFSTPQRRGFGLSYSAYGSPASTTSTSSTPGAFSNTLLGNSSFNRTLSKSMSTSSLRRSFNTEDSILAPGAFSASPRNRSLGSTGNVKKLTISKNIKSDLFNPLATQPQAIAPSNSGILKKRVSFDANTNGNANLNINGTSSPLKHANSATPSSAELGYMRPHSSGNNSNSAFSSLNSEAEPVANSNNQLAIVREEETHDPGEANALELMKDKNPGEYWMSPSKTELEKMNRVQRQRVSNLIVGRYGVGSVQFDVPVDLTSINLDDIMDGIVKIEVRQVTVYPDNHKKPPMGKGLNVPSTIILENSWPRKKDRKTPLIDKSGIRLQKHIDKLKKVEDTEFVDYDMLTGTWTFRVPHFTTYGFPEEDEEDEVEVEDTRSPNENLRSGISDFFNSSYTSTSQLTRSEYGPEDTFEFRKSKKILPGTFDSQDVFGDTDETTESFEQELNIDNRSVGSLSDIMTEEPMDNYSGMYESDSVSIMDQEMVGSFIDNENSMQLIEQSKSQYDGFTSYDSPSTQRFLACDDWISTLQATVSPKKKSRALLKSLAQPQDTYNKSSPTPAQSKYTSDKKGFSTSIDLMNSLFGQTNGSVKSIKTSRNYGESEWPRAKRTEISDENNLQTVDIETLFHNSMKPRWGPDGTLIYAAPLLGRGSRIKNDLLVGLKREIVSEHRDVRFAKFSNEASTDLLKKHKEITVIDDTCDIPQAVLSDNLMFTDLIDENASKYEKLVWQLASILWDSIQIPEELFEMPHIESRIRKTNLSKFWEKIVDDTSSRQVALARSNEEKAIACLSGHKIDDACSNLVAAGNMRLSTLIALIGSKDSIKSDMQAQIDAWQKSQILSEMTQPVRALYELLAGNVCVCDEVKGPPEDRVESFSISKRFGLNWRQAFGLRLWYAISVDDPIEAAVECFANDLSTGKEESWPSPWYVEQKVPELWQDPCVNEREDLFWGILKLNTFENADLEDVLRPENSQLSPMDMRLSWQLSQAILSLGSIKFVGDNDVKSDQTTLSFASQLINEGNWLDATFVLLHLSSPVARMMAIKDHLGCNAGHIGTVDCPNFKALVQSFKIPAAWIWEAKALYKRSVEKDPRGEVECLLKAGCFNEAHQTFSRMVAPKAIVELDYKSLDILLKDFAGKDITIGDWPHGGGLYSDFLTLIECEETSCYPVDELVLERLLCGLPSVAEESRQTNFMENVAIGFMSDVVAKTMISLAKNGMKISLAKILNLPLTEDKYLKYSVEISTVYFRDVMAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P499</accession>
    <name>A0A0B1P499_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P499"/>
    <dbReference type="STRING" id="52586.A0A0B1P499"/>
    <dbReference type="HOGENOM" id="CLU_047737_3_0_1"/>
    <dbReference type="OMA" id="WYSRDVA"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="37671" checksum="88BFA6C02D39ABFE" modified="2015-03-04" version="1">MVREMKISFLMTSQKIGFNNIIGRGLRNWPKIATVSHCPGCYRQISRTYGKLTQPNGGREFVSILDQPPVLVRAGRKKHGPGLIILALIPVTAFALGTWQVQRLKWKTNLIAKFEDRLVRPPLPLPPRVDPEAIHDFDYRRVFTKGHYRHDKEMLVGPRVNDGKDGFLVITPLERKENGTSILVNRGWIDKKFKDQKLRDPIMGCPQGEVQVEGLLREPFKKNMFTPDNSPEQGKFYFPDVKQMAEIAGSQTVWIEETMTPDLITSWSRESKGIPIGRAPEVNLRNNHAQYIFTWYALSAATTVMLWMVVRKPPPDITRRVRQSQEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4J1</accession>
    <name>A0A0B1P4J1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative frequency clock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002747">
        <property type="protein sequence ID" value="KHJ31599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4J1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4J1"/>
    <dbReference type="HOGENOM" id="CLU_007103_1_0_1"/>
    <dbReference type="OMA" id="QTHENEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018554">
        <property type="entry name" value="FRQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09421">
        <property type="entry name" value="FRQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="859" mass="95875" checksum="10A88431D8B5E99A" modified="2015-03-04" version="1">MSSVRCSSVSLKQKASENSQNKDQSNKKQALKPCSKSTQLLSDLAVILDDVQAPLNNAPSQENASVSENSSLSRLSDENCSISEDYSTNLHKWFDDFNRHPEKTASKYRDTGSPYFLQQNLTTSSRFNSEIAQIPDANYSRRTGSTDDYRSVIDDLTIENKRLRKKLRRFKKLSSKQLEKDKLFEIKIHDLPPAKRRELESALHSFASSIDFSSCGLRSSEQSLGQSQSPEETSISKKKSSTSSSINSNLEQSSYDSAIMSTLLTTVNSEPNIFETEKSTSLNPGFNTCESQSYVKPPCSEKLSKYSIKDMSDRQKKKLVVQRLEQIFTGEKAAVMGMPHQSLNKDETSKQTHENEHLMNYGRVREAHMIPQENYSYSRPIDLLDNSETKTSSHSSDETNSNESFSNQRPTRLRELDPDRTQIPSDNVEYIRHLGLSTPQLANDESEDGSKEKGGWVYLNLLINMAQLHIINVTPDFVRSALVDVSEKIELSKDGQMLRWKGGSLGTNLHNDDSSSGKLSCHSSKRKGSHVYKSREKTEFPARRINSSALNEPHPSLTDFHYKPLFFPRVTPEQASESDESPSGPSLVDESICSQDLWCQPRKSRPLSCSIGKRQEDGSLVFYRGADFCVDLSGDPESTTQLSTSILEQDSEGEQNLSEESHSPIIERTSSGSLLPFRPFKDPKSLDLRSIEDPNSYQSSENSSNCQLELSRFPTETHQGPIVPQALQPCGIGGSQISDHFEIHVLTQHSVTSANNSDNNYSTSNNIERKTELSSPEQKAESLPMKTLEDRVNDQVASRGIKSLSLISSSQKVSLTPPSQVQSKIISSETVYLPPSKLPSPATLQYSSDSDLDLDYNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N3</accession>
    <name>A0A0B1P5N3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001927">
        <property type="protein sequence ID" value="KHJ32640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N3"/>
    <dbReference type="HOGENOM" id="CLU_1120814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="27158" checksum="A61E90EB8308F2C7" modified="2015-03-04" version="1">MNETELAAVDNMDLTPLDLSIYTNTVHFDRAATFIMSRVHTKYQTNHAVGGNPIQASVAASVRAYYEVSGATSRSNDAKELLDAVVKGIYWATHPVNEALLLPSVIRNTRIDGAYVPRDGPAPQYLPTEEYFDIRANTAPAGTHHFLVAAAAIKALKPFGLLALLPEPARLQEIEDGLALIETYGAALHPAARHWGLNKQSVSQKTVEPLCADQGYAVKKTVEEQLIKGVPYPEEGGPTEWRLENSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P1</accession>
    <name>A0A0B1P5P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001346">
        <property type="protein sequence ID" value="KHJ33593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5P1"/>
    <dbReference type="HOGENOM" id="CLU_116873_0_0_1"/>
    <dbReference type="OMA" id="YSTWIHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21143" checksum="4D60C2BC6ED64683" modified="2015-03-04" version="1">MPFHRYKQCKPYTQDKQKSEVTSHARKKDNRIFTRLTKDHPSRNQHIHAIKTALIDKLGSEGASVKAVQKVKSGIAIIPSNEKHAEKLLGKSQTITSVLGGKVEKAGEWMTYVVDHVPRKLHSLNGKEIVATVELARKEVEAVTGSVPTRVLWFRKSLVENPLPTGTIVASFFRKKCRILGCPGSAPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Q3</accession>
    <name>A0A0B1P5Q3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutamine amidotransferase class-i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001095">
        <property type="protein sequence ID" value="KHJ34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Q3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Q3"/>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="246" mass="27942" checksum="141CDB7965217427" modified="2015-03-04" version="1">MTTLRIAVIECDVLSPQSHAKYGGYHNLYRKLLSKAAANMRPSPNLLVSSYNVHLLGSLPVVDEFDAILLTGSRYNAFDDDIWIKQLVSYVQTILSERRVRVLGVCFGHQIVARALEGQNSVGRSRFGWEVGVTNVELTERGRKVFRTSRLALHQMHRDEVLVASRHVELLGSTAACANQGMYDYRRLFTIQAHPEYNEEIVTELLQIRHDKGILSNRVFHDAMERAKLPHDGILVGEAFLRFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S3</accession>
    <name>A0A0B1P5S3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c2h2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5S3"/>
    <dbReference type="HOGENOM" id="CLU_024747_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="504" mass="56848" checksum="7E5F0785A03ECD88" modified="2015-03-04" version="1">MSPDILISYKMFDLIPAESNHENFSLNLATNAWNCDQFHSDNTAMARFPSQDSIPFSLSNSASSIKSVFMLPGNFDDRTKMNSIECQGIVPLIEGQNYENSHYPEEISTCQEDSKLFTESHHMSNMSTNDYQSGMKYGINLSPDSALNDPKLSTHSFWDDVSTVSSPEILPRYDEWCHSPMISDSICFSSNTQASSPRFIKKYPDLVGKPEHSLVDCMNKMDVRSCTFGLKDVVNISEHPSFRGITTTSNEKFKPSKRSVIDSENVRTHPLYHNAVPQEDGLYHCPWENDPESNCQHKPEKLKCNYDKCVDSHLKPYQCKVASCKGLSFSSTACLLRHEREAHAMHGHGDKPFLCPFEGCDRGILGKGFPRRWNLRDHIKRVHKDPISSSTQTSENSESSTESSVSGISESTNCTKRRKRGTKYSAQLTFKAASGSSIVKKPKKSILIKRYKQKQLLLLETVKKLQDPKQHDNMELLRNANECIEVMVETTQMINSVPCVVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P655</accession>
    <name>A0A0B1P655_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001821">
        <property type="protein sequence ID" value="KHJ32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P655"/>
    <dbReference type="HOGENOM" id="CLU_163547_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="8026" checksum="E2E7AA8091FFD269" modified="2015-03-04" version="1">MRPVKSKSSPSRGAGVNAQYALHVWDSQEDSHNPSLQDLPFIPAGLNRLRFYITFPSAPFFTKPPTIGPGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6A3</accession>
    <name>A0A0B1P6A3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000988">
        <property type="protein sequence ID" value="KHJ34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6A3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6A3"/>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="76"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="28848" checksum="95163EB2C9FFE8C0" modified="2015-03-04" version="1">MRFIPNLISRQRLICRMTTSTMGSTSKLIFAPANDKNNAQAEQFAKGTLEFSQLDPSPFIQFQNWFTHAQSSGVFHPETVCLSTASLPSGRVSGRMVYLKELDLKGFIIYSNFGTSKKSKDLEKNKWASLTFWWPEQERQIRIEGLTERLTTEESQIYFNTRIRGSKIGAWASKQSQSIHDRNVLDQWVKDIEKNFEGVDSIPVPDFWGGLRILPEMIEFWQGRDNRLHDRFQYTRTAENWKIERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K5</accession>
    <name>A0A0B1P6K5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001684">
        <property type="protein sequence ID" value="KHJ32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K5"/>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="133" mass="14552" checksum="A2855E00BDE6057E" modified="2015-03-04" version="1">MSSQPLLQSAPGKRIALPTRVEPKVFFANERTFLSWLNFSVVLGALAVGMLNFGDQTSFISAIIFIVVAVSGMIYALYTYHWRAKSIRRRGQAGFDDKVGPTILAAALIIAITVNFVLRIIEAPKQETSPIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N4</accession>
    <name>A0A0B1P6N4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000929">
        <property type="protein sequence ID" value="KHJ34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N4"/>
    <dbReference type="HOGENOM" id="CLU_002055_4_0_1"/>
    <dbReference type="OMA" id="FIVYANI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="232"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="667" mass="75654" checksum="F2212B4BA270CCB1" modified="2015-03-04" version="1">MAISMKNVPVEAHWSIGKVERYHSCIRRAYKIIVEELHGTGVNKDCMLQMAVKALNDTAGPNGPVPTLLVFGAYPKMTISDPPMPFVVQRANAIKKAMQEINKLRAKHYVNAALDHRNGPNTSSLHDLPINSDILVWQEGPTSVRPYYQLENDYQQAGDEQVNAETFTNDEVTAPRRNEQRTRNLPLRYRDTPNLVVFLKSDETICQTSFEKSRQKEIQGLLEKGVFDYVCLSDIPLGTRIFNSRFVDEVKNKGTDKAYEKSPLVAQAFNDKGKDFVLTQSPTIQRVSQHVILALSVTLQLNLYIRDISQAYVQSSTNLCRHFFIRPPPELAEEGTILKIIKHLYGIPEARNHWLNTYLRHHTDKLQMLQSTYDPCLLYSNCNDDLCILGIQTDDTLFGANETFCIKEQTQLAKAGFIAKGREMLTISTPIKFNGGKINLEEDNSITLTQAQHCENLSIIISKSIDTISPRSKIRKLLGPKEQYVAQRARGPYVASTCQPEASFDLSSSAQIIDPTETDIKQLIQRINWQIKNSYRGIKFVKLDEISLKVLVFVDSSFDNSKDLSSQIGFIVILADKENRANIIHWSSTKSKRKTRSVFAAELVGRTRLFIVYANIRFQKLVFVLNLIIYMFVVYLFYVLPTGVGALTSLVISRVIANPNNIRHYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P743</accession>
    <name>A0A0B1P743_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002042">
        <property type="protein sequence ID" value="KHJ32489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P743"/>
    <dbReference type="SMR" id="A0A0B1P743"/>
    <dbReference type="STRING" id="52586.A0A0B1P743"/>
    <dbReference type="HOGENOM" id="CLU_097982_0_0_1"/>
    <dbReference type="OMA" id="HQTYDLC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079796" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="19718" checksum="3F928FAAC9C909CA" modified="2015-03-04" version="1">MKISVNILILTTFAFSAFGNVIKPNVKRSLLEGSQAIISDNMGISVPGENSFDYCDQDYTSDILQLDYVNLNPKEPKQGQTLLIEAAGNLLQEVNYDAYFRVKVSLGLIVLFKMESYLCDQISKVNMTCPLEKGPIMVKKEVKLPLVIPPGHYMLTADAFTDENERLLCLTTKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7G9</accession>
    <name>A0A0B1P7G9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001769">
        <property type="protein sequence ID" value="KHJ32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7G9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7G9"/>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="37400" checksum="A737892E6DEF669B" modified="2015-03-04" version="1">MSTTKTEIREIPVSQYDLGKYWGRVRHAATISDPRTLFVSKSGIESAKNLIAAYKCGEIKQINDEYWKARKIVDSTLHPDTGLPVFLPFRMSCYVFSNLIVTAGMLTPRMGVTGTLLWQITNQSLNVAINSANANKTNPLSTFKTLQSYILAVGTSCSLAVGLNSLVPRMKQFSPATKTILTRLVPFFAVASAGALNVFLMRREEILEGIDVYPEVTHSDDLETAHKTIEESNLVSLGKSKKAGLIAVSETALSRVLNSSPIMVIPPLILLKLQNQNFLKRRPNLTLPINIGLIFVTSIFALPLALAVFPQKQVVDASVLEKEFCASNGENRKVSFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7I4</accession>
    <name>A0A0B1P7I4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000761">
        <property type="protein sequence ID" value="KHJ34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7I4"/>
    <dbReference type="HOGENOM" id="CLU_994647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058954" evidence="1">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="25974" checksum="63DFC6A2B0862B98" modified="2015-03-04" version="1">MYPKAILPIALIALTLSAHATPINTQRTNLKEISNLLRKRGATENAEAEAGNPLSAISGLLGGAGGAAGGDLLNNLPIKRDVAKRAPLDLSDITGAIGGAGAKGDAAAAGDADAGNPLSAISGLLGGAGGAAGGAAGGAAGGDLLNNLPIKRDNIRREPLPEVLDGSLMIGVKSSKFLGNQFSVASASKVLGASGSFSAGGSLGPLGPSGSVSAGGSVSPFGASGGVAAGGSLGPLGPSGSVSAEGSVSPFGASGGVGAGGSLGPLGPSGSVGANGSIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7W4</accession>
    <name>A0A0B1P7W4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001653">
        <property type="protein sequence ID" value="KHJ33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7W4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7W4"/>
    <dbReference type="HOGENOM" id="CLU_090404_1_1_1"/>
    <dbReference type="OMA" id="PIPWRFS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="180" mass="19982" checksum="99D7C7C967793094" modified="2015-03-04" version="1">MDSMSDMTMGGMHIDDDRPKNSMSSMSSSNMSMGGMSMGGMSMGSMTMSSMSMVFFNSIKTTLYMSMWTPNNMGSYAATCIFLIFLATGHRFLFALKSRLEAYWSDLDVNQRLAVTSGKLPLSERIAMDPSSRKMVLSEMGVEEDVIVIQKRKLSTPWRLTVDPIRAILDTIIAAVGFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P829</accession>
    <name>A0A0B1P829_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000882">
        <property type="protein sequence ID" value="KHJ34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P829"/>
    <dbReference type="HOGENOM" id="CLU_529135_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="578" mass="66201" checksum="F049B7554D3A9166" modified="2015-03-04" version="1">MVGKTNLELESILNNAVARLEGADKETNSRIAKLEKSINERFEKTEKKIEEGFNKVDYRFDKIMTAISALHPNNNKGKEKENEPVDFHSLEKDNTGMKISNTNPVISFKPSSMNMAAQDTSSSDQPLSKLFKSSTNMPSFSSKSTFAPKRKFPQASASQYHSDPPQSSPSFKDKEGAVNLYRPPTETSLILTQREKMIRQYFPDFFPRSEADNPCGPLREATNRNRVVFPQDWKLKFADPNTLEKVYKMQVAMIQSMLPYTAWPVRVALEMEEDFLAVRRNVHNHSLDWAGTVDCILTVLFKHNMLGAPLTNLARLTVLKGETSLQFARRLRKAIYALPNDLLLGTQVRDIQRNHIQQSLPRTWTNIHREVTTMANDELADYVVQVTEGIGRWNLEDSVYQQSNNYSPIPAIASENISNPNFGKLSTQIDELHNTNTDIFATSHDTIDTALDPSFYTNSSRNQCFKCGKYGHWANDCKSSHKQQYSNRPQNRPTSNTYQNKFSQNLKDRFLALKNKGLNKPRSSKVYEKSQHKNRIFVTNQESNEDDRIRSGVERLEDDQVESELETFLQECLEQEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P841</accession>
    <name>A0A0B1P841_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell cycle checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001811">
        <property type="protein sequence ID" value="KHJ32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P841"/>
    <dbReference type="STRING" id="52586.A0A0B1P841"/>
    <dbReference type="HOGENOM" id="CLU_035754_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="27929" checksum="BB80A7A9D8A037A3" modified="2015-03-04" version="1">MPVLSLTIVTHIASFSNAATSAFLGEANFNNVGEHMFQEENLDADLGRERETVVTQDIPVRVLTTESVEGIHEPRVREPDAHIILPSLLQLKSISDRFTRLAVATSNGTVRGTSSVIGPKLELAANMHGSLKLSITTDVLNISSVWTGLTNPVLDPKQVEDGEESLEDHPSTKLREAGPDAWSKVLIDGKDWGRVLSVGRLGGRVIACFADGHALILYVYLTNYEGADESVLTSPSLYTPWANRGGLREKGAEERVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8E5</accession>
    <name>A0A0B1P8E5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative mfs drug efflux</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001724">
        <property type="protein sequence ID" value="KHJ32924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8E5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8E5"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OMA" id="GQFNAKW"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="533" mass="57485" checksum="252214F5F7B9631E" modified="2015-03-04" version="1">MSVAEAQASDNEKGPIEIPEHSPRKITGWKWIAFMVAVLSSAFLFALDNTIVANVQPVIVLEFNSISKLSWMSTALLMTAASTNLIWGKVFAQFEAKWTYIICVAMFELGSGICGLAQNMDTMIIARAICGLGGSGMYVGVLTLIAANTTIRERPLYISFTGLVWGLGTVLGPIIGGAFSVSAGGWRWSFYINLIIGLVCTPVYIFLLPKWDPRPGVGFLERAREMDYLGSVLTVGAFLSGVMPISFGGVQYAWSSPEIISMFVCSGVLFIILGIQQTYCILTTKENRVFPVEFVKSRTMLVLFGCSAIGGGIAFLTIYMIPIFFQFTRNDSALESGIRLLPYIFLLIFGIFLNGFVLSLYGLYMPWFVIGSVFSIVGGALMYTVTSTTSIATVYGYSVILGWGLGLYIQSGFSIAQALVEPNIVSLAIGFISCAQLSGITIILSTANSIFLNRATSSLVALLPGQSQEQISSSIAGAGSTFVKSLDSELKVKVLSAVVRANSDTYLLAIVGGALTLVMSLLLKREKLFMPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8G9</accession>
    <name>A0A0B1P8G9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001307">
        <property type="protein sequence ID" value="KHJ33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8G9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8G9"/>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="OMA" id="EWKNDVM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="74651" checksum="D1696F3F6D4B1DCC" modified="2015-03-04" version="1">MKTTWKDIAPVPTSAEFLDIVLSRTQRRLPTQIRAGFTISRIRNFYTRKVKYTQETFSEKFSLILNGFPRLQDIHPFHKDLLNTLYDADHFKIALGQLSTAKHLIEIVSRDYVRLLKYAQSLFQCKQLKRAALGRMATICRRLKDPLIYLDQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLRSITRADVDVQPYAFTTKSLFVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSVILYFMDLSEQCGYSVQAQMQLFKSIKPLFANKLVFIVINKIDVMRPEDLDNETQTQLQDLLKSSDVEMLQLSCTTTEGIQDVKNAACDRLIADRVAQKLKAGMNNNGAVGSRLSNVLNRIHVAKPMGGIVCETFIPEGVKNLRKYDKNDPNRRKLARDIQDENGGAGVYNADLKSDYILENDDWKYDKIPEIYDGKNVYDFIDPDIEAKLASLEKEEEKLEAEGFYDSDEEIEDAEDAEIRMKAELIREKCQLIRNEAKMKKSLKNRAIIPRTATRKNLSDMEKQLDTLGFDTTDIISRTRSKSRGRSIVRNRSETTDLMDIDDPNFEGKMRAKSRARSQSNRRDDGVTNELARSKAERAQKLSQRKMNRMARQGEADRHFGTAMPKHLFSGKRGMGKTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N4</accession>
    <name>A0A0B1P8N4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative vacuolar protein sorting-associated protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001661">
        <property type="protein sequence ID" value="KHJ33029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N4"/>
    <dbReference type="HOGENOM" id="CLU_024079_0_1_1"/>
    <dbReference type="OMA" id="FNEGPNI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="465" mass="52474" checksum="CDA0C430BA14623F" modified="2015-03-04" version="1">MSGKIEQDRDDARMELEDISMDDLEDTAFLTGNISQGGQREKKKLWTRIFIRKIALLIEFAGIFKVVIVLGLIFLIALALLAFVNGEDNSLPTSLPNISTEKARQVAEELKNTTISSYVLTYAPIVVLDRKETFFPSDLSTHIANTQPRFNFTPILNTPFPLNLSNLDQLNTFDNGEVYLSSREPIIHLPMWLRGQKPGKKTLHTRRSVNCVIIVIEKGSFKDEAENIEQNVVDAFYLYFYSYNDGPRGLGHQVGNHIGDWEHNMIRFTNGTPTAIWYSQHGYGSAYTYDAVQKIGVRPVVFSARGSHSNWPEAKAHDFHIINNRIPPHIAYDYTSLGRLWDPTLSAFFYSYNVTNTTSSPLTTSKEQTFPSNGTYIPALSSFPTGFLYFKGLWGDQQLKAGDEGQEEIHGFYKWTSGPKGVGWGDKYLMRDTICPKVLDSDGLPEAEKSGEKNVLKECIIRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8P2</accession>
    <name>A0A0B1P8P2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hsp90 associated co-chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001281">
        <property type="protein sequence ID" value="KHJ33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8P2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8P2"/>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="OMA" id="INGCHAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="31331" checksum="5FF9205F1E565241" modified="2015-03-04" version="1">MSTPAAPEILWAQRSSTTDAAKNIIYLTISVPDVSPSDLKLDLKPQSITFAGNSSSQKRNYQVTLDLYAEIDTDETKINHTAKNIELVLRKKELKEEYWPRLIKDNKKLHFLKTDFDKWVDEDEQDGIPDENLANMGGIGGMPGMGDMSSMMGGGGGDFGSLDFSNLGGDMEGEEADAADDDDDDEEMPALEGEEEKDEPSASKSAEPAESSGKAKIEEPAKSKSSPSRGAGVNAQYALHVWDNQEDSHNPSLQDSYSLSRVSIVFVSTSLSPQRLISQSPPRLAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8P3</accession>
    <name>A0A0B1P8P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000542">
        <property type="protein sequence ID" value="KHJ35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8P3"/>
    <dbReference type="HOGENOM" id="CLU_188546_0_0_1"/>
    <dbReference type="OMA" id="DHRSELY"/>
    <dbReference type="OrthoDB" id="4987761at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="88" mass="9809" checksum="9FC2D261F840F5D8" modified="2015-03-04" version="1">MGANLSSTEVVDLSGTYISESDQRSDLYLLLFTSGSIYAMGMILGATQLVDHWRGPYGDRPVDFFRVILAIILSTGWPVILFYIWCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P994</accession>
    <name>A0A0B1P994_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01000452">
        <property type="protein sequence ID" value="KHJ35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P994"/>
    <dbReference type="STRING" id="52586.A0A0B1P994"/>
    <dbReference type="HOGENOM" id="CLU_030117_2_1_1"/>
    <dbReference type="OMA" id="IFARQKM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="476" mass="54123" checksum="DA1640B26D418BA2" modified="2015-03-04" version="1">MEYDPDVPIYSTADRISFSYTTARDRWPVILTGAIDDIHKAVSETTDEQKREEGKKITAELAKLKYELQHDRILTELSDDGQPDIAVYNRELNAIGNPTWLNCPWLFSECYLYRRIATYFTLSQYWKNYDVFADKKTSTFRSSRFAVIELAYRYQELVSQIQNKSPKSQMETDAIEKAMFMEVCKICLWGNATDLSLLAGSSFDDIQKLQGIDANKSSDSRMLINDINLAYEVLKEAKKTKKSVRQIDIVLDNAGFELYVDLILAGFILSTGLATNIILHSKSIPWFVSDVVPQDFQVLLNALANPQSFFSNPNDKETIDSKASEPLAPKEIDALNFVFREWSKFHTEGQLLLRADRFWTETGSFWRLPTRAPQLFSDLKASELVIFKGDLNYRKLTGDAKWDTTTSFTKALGPLGEQSGINILSLRTCKSDVIVGLKQGEDENLRNTEDGGGDSGERRWAWTGKWAIISFSRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I2</accession>
    <name>A0A0B1P9I2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I2"/>
    <dbReference type="HOGENOM" id="CLU_1797878_0_0_1"/>
    <dbReference type="OMA" id="CFKHLTR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="16178" checksum="443DB650BAF2D524" modified="2015-03-04" version="1">MSQEEAPPLPVPPPIPSQKKSCSARPATSGTQLNLRANREKASCAFKISREQERIYITKRQAGFGKQEAQKAKEHLQSAQKNLYAGVTCTWHAAANLPAILKEKRVDQKQQRILKQKEREEEAKRELERIMAANNTTDEASPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J7</accession>
    <name>A0A0B1P9J7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">EV44_g2740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000621">
        <property type="protein sequence ID" value="KHJ34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J7"/>
    <dbReference type="HOGENOM" id="CLU_084856_1_0_1"/>
    <dbReference type="OMA" id="TNPHEYF"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="188" mass="21378" checksum="339B23BEC95DB7DF" modified="2015-03-04" version="1">MERQESSSQATDALNTSNSRLNPFFSRSLRQFSIFAAGAGLFAVSMAITRRSIVRKYHKDIPKFFNSSYPRNIEINGAMDALEALNLATLNICSVALMTTGGMLWALDISSLDDVKKRRYINTTKQTDPTQKDVLSEQVIEDWLTSLFERKEFKALGINTSLIKEQLQQNPEKNHKLRKEDDKAEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Z9</accession>
    <name>A0A0B1P9Z9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bgh specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Z9"/>
    <dbReference type="HOGENOM" id="CLU_338307_0_0_1"/>
    <dbReference type="OMA" id="FHASSEK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="794" mass="89190" checksum="512846E40ECC7393" modified="2015-03-04" version="1">MISLVPQSTPALCRPKLSNTLRTDDLLNSDFLHRDFHSDIDSDSSSICHSPNWDDISGKKGRNEKREKQRREKDIEKERSLKMMATKTVTKPKKLSKLPPNRKPRSIELSGNGSETINNSPGLQYRANVILPILKVTGPRKSNDLGKKPALAFNSSSSSKVSQINKDWPGREFIGGLKLRKVEEAGVQETIRQVKNKNRIRDENKTPPLPKNRVPEDFKPSIVGTTARSYREEFEWQSRQEDNSSVHQSMAPSLSYRSTTSDRDYSNIPRNFHTYHEQSVNEAHKEQDSRSPVHNFKLAKISNQPRTTRQVNNQFKDGDFDFAYPQHQSSQALNCCPINREQKNNTIKSNLDSLSPKLEPKFHASSEKMTVYPRRPKSIVHTISGVGTLRPATKKTSNKASETSTEPTILPPENIETSFHHTLPYSFINSKIDSETANSSYCRNSSSSYSDIILDYADFQYDSASAEGSPTSGKPVNEWSDISSAPSLMDSAQPIKRSFDSSESRSYFSQVKSAGSSEENSLQDGNSNITTPIESRPHSFNDGSSLKSPNEIQPKEVVSQMELEFHKESNPTGKGANKIGLEGQDYAKIHMNNENQLGYPSQVESQPNQVETPRIVKRHDHQSFSGSPKIQGPSNSYFDSCQTSWGNSNEMNNEEMPLRGLIKRPKDASRSQNSNLRSDESNYSQYLKEARLRIASDIASPRLSRNVRDTSLSHQKSEPFAKMFVICCSCRYFHDMPSKLYACMAKPDDMVTEENLGVNGVITTSVKCPWCGHGMSTSCCAGYAAVVFMKERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA56</accession>
    <name>A0A0B1PA56_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative anaphase promoting complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000340">
        <property type="protein sequence ID" value="KHJ35587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA56"/>
    <dbReference type="STRING" id="52586.A0A0B1PA56"/>
    <dbReference type="HOGENOM" id="CLU_039415_0_3_1"/>
    <dbReference type="OMA" id="SIVHIRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="51"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="29276" checksum="BE11117FF6635E95" modified="2015-03-04" version="1">MSPTSSNSLWQTESLENENYHDNGSVSNAAAERNDENQNIYPRGSSVEEEEEGIEKVHMDVDIPFDPASFGFKEIGNLASWTVSSCKPGCGIEALRDEETSLFWQSDGPQPHFLDIHFSRLVSIVLIRLFLDFDADESYTPTRIMLLAGTGYHDLIPFSNLTFEQPRGWINISLDQVGGGEDGKTLKAFLLQVKIVENHQNGKDTHIRGLKIYSKLERDRDAHCDIRESANTTENIIPKTANDKNWLAEPDWMGDFQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA79</accession>
    <name>A0A0B1PA79_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000498">
        <property type="protein sequence ID" value="KHJ35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA79"/>
    <dbReference type="STRING" id="52586.A0A0B1PA79"/>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="44296" checksum="71761ADA25E46B21" modified="2015-03-04" version="1">MSFMKYILVSLPTSIASNDSGEAFNTIRSTVAGDNVATVPFKIPEFKTGTLDILVRQADELAKLEGNCAATVAKINDYLKSLLEGDEEKVSQQKKVNDKPADQYLRSFCWNKIKYRTDKPLVELIESLRKELLSIDNDVKAKITQYNQIKTSLNTLVKKQTGNLSTKSLASIVNPSLLIKDSEHLETHLIAVPISDKKVFLQSYETLSPMVVPRSTVEVAQDKEFSLFTVTTFKKYSMEFHNKCRESKWTPRPYKHVTGGKEEEQKEIDQIEKNERKVWGEALRLSRTGWSESVMIWIHALTLRVFVESVLRYGLPLDFVCALLKTNPKSAKKAKTALDSRFSYLGGNALVKDKSGKVTKDDSVLSSEIAAAGVGGFGEGNEYTAYVYYEFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA86</accession>
    <name>A0A0B1PA86_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dynein intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001350">
        <property type="protein sequence ID" value="KHJ33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA86"/>
    <dbReference type="STRING" id="52586.A0A0B1PA86"/>
    <dbReference type="HOGENOM" id="CLU_012999_2_0_1"/>
    <dbReference type="OMA" id="MHDRPEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="506"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="695" mass="77483" checksum="3D58D5C921DC2D4C" modified="2015-03-04" version="1">MMQQRRDEILAKKAKLAELKRQRELRSRDISFARHSIGSPSDPLSIPPSRAENREELDKYISSILVSGDKKKASSIGGTGSQLDKSSQSSSTGELRIENLELSTNALSSKLSISTLNLSTAPSTTVYEFIPSPVKEVYTYSKAVQTTNDWTDQLSRQNKIQDDSEEENVGTPLVKKRLNRRARDREEELREKIRLEIEEELKETRESKLNESLQNTQNNSLNFPSRSLTEEELNAITSSEEFMDFVERSSKIIERALDQEYDILADYARVGSDDVNDEDDEYGNIREKGRRRVKEIAQFYDEKWCKKRMISDINFSSKFPELLLAAYTKNPSASYEPDGLVQIWNMYLHERPEYVFHAQSDVLTANFSPFHPNLIFGGCYSGQVLLWDTRAKSSPVLKTPLTGSGHTHPVYSINIVGTQNANNIISCSTDGVVCGWTVDILAQPQEKLTLLTPPPSKNEDLAPTCMAFPQTDPTYFLVGTEEGTIFPCHRYDRAGAKAGVDQRVSYRGHAAPVMSVDFHPTRGLVDLGDLVLSSSLDWSVKLWKVRAPAATSTASVSGEGLSVDPILDLTREDVVYDAAWSPIKPGVFSIVDGAGNLEVWDITIDTEVPIARASPSTRKDSRSIVTKSLNKVAWEVTEGKRIATGGIDSCVTIFETGPDLGGKENTRNEEWTSVKKQIARLESINPTLVHNSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAA3</accession>
    <name>A0A0B1PAA3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000977">
        <property type="protein sequence ID" value="KHJ34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAA3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAA3"/>
    <dbReference type="ESTHER" id="uncne-a0a0b1paa3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080570" evidence="1">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="46"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="66913" checksum="D759CFAD3303EEE4" modified="2015-03-04" version="1">MVFLNFLINFFLFTMSCIAVKNLQQSVAESPIVKLAKGITHKSVYNGTGSVEYYSFNGIQYGRVLDRFSPPAPICHKSFFKRCPKENPNISKPRLSNNLPRGYPKCPQAIPDWMTFKNEKHLEKKSIKIPDNEVEDCLFLDVIVPKKVWDQTHDHSLQSFAPVLVWIHDGGFTSGSRILHEDPSILLKRSLEIHGEGTIIVSMNYRLGLFGFLASERYPSDKDSYSNVGLLDQRMALGWVEKHIVKFGGDRFRITVVGEGAGAGSIMHHLTAPNITRHFFPRLHAKSHFRRNFPFQSAILKSPTFQPIVPSQLAVIVTQILEKASTVKGQLLNRISKLHELPYETLYSLNLAMVRESPHGTFTFGPAVDYTKDHRSYVPDFPLRRIKAGQMAKSINILVGYRRNEGYYITPSSMKTDLGFRDHMARIFPTIMRNEIAYVSESLYPIQDYESMDQGGMNRSIEALSDLFTICNIHYLLLHMVQSYGFVLETSLASREHFLKRALMADSMIYMNDSKTQSKPNWLQDMFLRFAMFASLGAEEARVRPYDGNAKVLLASDDGFQGFINDPSAKYQCRYWADAPYGIAPPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAI5</accession>
    <name>A0A0B1PAI5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000942">
        <property type="protein sequence ID" value="KHJ34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAI5"/>
    <dbReference type="HOGENOM" id="CLU_001112_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="855"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1576" mass="177508" checksum="29DF91D249074D72" modified="2015-03-04" version="1">MEKDVNQNIKPPLFIKENKILGQPLHLMSEQNSSYSSKIPFLTSQKILSTKIGHKDLPESRKNGKNYQLGIFKQVSTIHSQNNIIENAVTSPDHRPTSSSAVKSKENGMTIYPPWTPRAHLKPSRTVSTSLESKILTNPMSTFTLNNHSIVGKPSVKNLLRRFDSNYGDQTTNTSIANDKKIYAFKGYGKTEKSNKESQNGAVSKTKTKLSSDFNSSGTIHKSIVSNGTYSRGSSRKQSVSKVSPAPPTFLFAEVRQFDEKPSTITCNRTRRPRRTSDPSIQPNHSGPKISAPSLFIQHTESFGISDMSRPKAHNRNHSDLVDTKVNTLVNLGARSTSSPSSPTLNPPKSLSPKLPIPKTRILISTPMPAQAKKNEQTQTLSKDSHKILEDNITKIIPTSIEERDSPTIPTGIFYSPVEGSMLDGRTKSSDAVQGDLPILGLPGSFVDDDEICPSSPKKIRSKNLIRQSDTNLRRASSITCLVSSKNAISNDQSHEDQSESIYREKRTNPYVIEANRSTDESIPTKDFFEKDPSPPGAFQDEDTLLCCSLMLSAKSDVQFLTCEAADAQKNVENALNGMNNSQPLNHIYDKNDVELLDSKNSLGISDIIKSQIPPSDYGDFHHLIAETYYEASENGLIDSENRSAISSQGVFSKHSSWQTDFSIGIEYDYPRRKHSIKDVKFSPSSCDERSTPPPKTSIVPSVAPLKSNRNNLTMLSKFQNTNVSPQLPPVATGEGFTLKFTQNELLNTDTILIQRQPSVQNFQRSTSSPAHRSSSSVSSIRRPLSGVSTNISNSRTSSEDLNSRKDSIPTKYTHNDLYISKDKSNLDSEVRIGGQVETVEEMRLRDENRKRLYQRKMAIKELIDTEAVYFKDMNVVEEIYKGTAEACPNLDTSDIKIIFRNTEEIVSFSNTILEDLKLAALPIYSPRAPKAKTNGSHKSTSSSDPDKISIETVMIDETEEQRDRETFIGANFGKHLPNMQLIYTNFLKNSESASSRLLDLQKDPAVRVWLSECNTVAKDLTAAWDLDALLVKPVQRITRYQLLLKQIQTTTPYNHPDSEALIACCQEISKLLKDIDDLKKRIHMVAKIVGRKRKESDVVRMGIAKAFGRRSDKTNLNVSRMKEDENYLKISEKFGDDYLRLQVVLRDAEYYTRQVSIYVNDYLRFLSAIELIMRMSPAGYPEIESKWARFNVSMREIGTNFVEEHIFEVRKFVIEPFEKMISAYNGPLLAMKKRDKRKIDFDKHLSLKAQGKKVDEKLQNLSNEYSALHEILKFELPKLSQLTEKMGKVILERLIYIQEKWFGIWVQRFQIVLEDNELPRDITDIIDQFKSDFRFEENRLLELGIVNGKFWCESNFRGPRSSSHSRQISDIGNFSQLTTNESANIKRSSTIYSGNRSQPSSCFQSPSNSVNTSTVVETQSRGIPASPSEHIARRSFTSENGINVNSDYHTSRRRESLSTYGSYHDGPLQLTRPLSGIFHSSLPLENGNRSQSRASSRDRSIPRGYTVLYLAASLFEFNISATKKEAGYPYLTYQAGEIFDVIGEKGELWLAKNQDDLSDTIGWIWSKHFARLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAK3</accession>
    <name>A0A0B1PAK3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative rheb small monomeric gtpase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001108">
        <property type="protein sequence ID" value="KHJ34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAK3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAK3"/>
    <dbReference type="HOGENOM" id="CLU_290556_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="581"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118983" checksum="E09C51E15F4A915F" modified="2015-03-04" version="1">MANSRNNINVRKTITTYGKTRRKIINGSVFNTDTQEATTNIVNQNAVKDGLRGKDVSVDITSSNSRKSENSLAKPIDIYDFPSDDETQIKEATPRCGQESFQHVEPNELLQGNNNQRRSNIAINNVRSNSVPHEDAKSRLKAKSKNLPELTDNISNINQFNKKISVRRSPKLVRSISDSHSYLEIHEKKYKAKQFTATGPSDAPKSDKDNLKRKYTAVTSKTQLCKMSPELSSLSLITSKMTRLKENDTFDMPVNDDQTISVRSLPRRIAKTSNFNQRRNRSPVAAKVEEKKKIVEPSLLNDKGTKESLYISRELSSPTKKGHSLEIKYGNTASMSLEAQKVKKSRKQKQPKSASEITSEKAKPYLSLPANDLDMISIQPKISPERHSIWQDLLDIASDADQELSEISDSASHSYLESSTFRHDNSQLEPKNEATPPSENMHRLRMIDSLVQKAENLNPSDNVLSDELESDKESHTLSIKSSVSPSRSRSQSNNFEPLGSQVMPQESQSSISSLGVGPKFTYSQQRSMLAEEDLVKDLAFSLLATGQDHVGKRSRRGSVPKLKPLSSFHDEEEEDESQVLIKSVYELRKSGAIKRFVDECTDLFDRIGYPGKVNSIRRSGLLDLASKMRDTNFAQQFRANSMEQQLFLKLNEEKDAISGFLIMSILIALVMEGPVVHLIPFLCLNGFKKLIFNLLDFKLGIPKICKDRKTNMSKLAQSLLVEYHNQLLRSPSLDGKDLDMISPRTIALICLKKLFYQSRDVENSSSLISEELVEKLFTIMKLILSESLQKSSNDEISIDLPLVAECLQLYYTAASNFLDKNKWLNNYLPLLADVLELTLHHDLCDAHTEILKLTLQVTNQNSLAVEKFVQPSLILTLSKRFVSQFNFLNGSHSESQFSRILDHLSLLLGVLINFSESSPRVGEYLQAFKHTNDEDPLKDMIIIFQVHSENISQAESEQEVLRNVVLGYLSVTLGFLFLYPPIGNRLRDEKTKLLDCIEEFILIHKLADKKLIDEASNSQITAGLGEEEVQIEAHKELTERLERLVVMLKFENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAV9</accession>
    <name>A0A0B1PAV9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000419">
        <property type="protein sequence ID" value="KHJ35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAV9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAV9"/>
    <dbReference type="HOGENOM" id="CLU_003155_0_0_1"/>
    <dbReference type="OMA" id="MDIGDAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000122">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="619"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1268" mass="144885" checksum="D85E9ACF692AB277" modified="2015-03-04" version="1">MAICRSLKGPGKTPPRLIADLLDYVPKEVDNGFNLLAHPAQQFWNKPLFRRDQNDCRHILMKKDNQTQAPISENLNLEIPCHYFVSAICSSCKHHFKITLIAESRGCNEICNLSQPKYPLHHLILTNSSRARDNIKLSHESKYEGLYESYEYKCSRPNCPIVVEIRILPPRLSKNLLQLIDNAEILAERGSREIKKDPLRFSDLPAVNPYAALNHLASYLKDALSTIGEPRKIALRNKKFTLSFANDCTDLFKYLDFTYSDDQTEEGESNFFWGLPRITDQNRNFIQDVLEEINYRAYEMQTSPKQTLQSSLTVSAMNQIKIILGYAGYTQRTTYFDADTEEHPYYASLGAVEGFTDELLAWAYDRQCECDPSNKPYYLDCLDDLARGRNSYYLQTKVVMATSAGEYGTNAIEEAYNYFELSSNSRESDDYIISLYRARIALAPRLKEMAQSCLEKIAKHRNSSTLEALANDRTMTYDEALKYLGVNSETAPEFIEASAVVMFVDGDKSKVALALKTIAKEKPGNMVLQRAAATMASEMGQVTLSINDAYKRLQISSHEISDEGVLNYFQSLSNGAAAGSRDSFIEALQVIALDRNSHFLFAKLENPNAEVISCKAEPIGLDNIGNTCYLNSLLQYYYSVKPLREMVLDFDKYRMVLNDENLRRKKVGGRQVEEAEVVKAQKFVEELQKLFKRLKTAPTRSVRPTKELAALTIFSTQAAEQAARNYSIEGSKILQNNDQNQFDIGSGTQWSSPNSVTENEVEMIENVNEKIPGRDDNSSEITLVDAISLSYNSCEVENDKTLLSHQIIQNKYQKKQNMSDFEADTVMVNNIFQEVKPIPPTPERPSPALPNDMADIFGPKKKSCQSDSDNRAWDFGTQQDVTEVIGNVLFRLQCAITAIDYETTSGEQIDIIRESFFGANTVYTQKAHSLQKKVEAWSYILVFPNPNESVPRSIYEALDVSFDEQLVEIDKQLVPQFTSISKLPRIMQFHIQRTAFDQESLRSWKNRSPVTIPETLYLDRYIDDSNTLDSSIMSRRRQTWLWKKQLSKLEARYEVLTNDKKITPSDALLATRDLVNDIREEPIDGISIDNDFPRLLDIRIDELGMEIDEIKNEIGILQEKLQNQFIDMRNHEYTLHAVFIHHGEVGGGHYWVYIYDAENDIWRQYNDESVSQVRNRDYIFKHESVSEGSPYYVVYVQSSMQKELVDPVCRDLQQVERNGLDSYSTDPNSTDSLMSNRVEDINEVRHIEYAGEKLHYTNISATGPEGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW1</accession>
    <name>A0A0B1PAW1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative tubulin binding cofactor c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000419">
        <property type="protein sequence ID" value="KHJ35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAW1"/>
    <dbReference type="HOGENOM" id="CLU_032612_1_0_1"/>
    <dbReference type="OMA" id="YFQHEIT"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="383" mass="42612" checksum="1272FA6A75C21CE8" modified="2015-03-04" version="1">MADERFQGAAVNPPTKRRTSIYNKEYFHQYFHQQSSQLLEQIERLHEFSLVGGERQDAIEHVLGGITDLSNYVADASDQISSYDKRVYSDGIRILEEKLRVTQSSIAPNSKFKFVSRLKDDFAPASNVLEDLSLRLTHGTPQGLETASPGEVSNVTGFTRSPDEKDSCGELPLFPRNYNQEISKADGVRKPSFSQATKIDLSDHKDMHIILPPPASRATSMGTVTKLSGSIVDMSIPTTTKTPFASLVIKDIRNCLIVGGQVAGSAHITSVMESIIAVSAGQIRIHDCEDMKFYLYSTSPPIIENCTNIQFAPLPKCYLGPDQDLDANKWDQVQDFNWQKTEHSPNWRILPEEDRLAENIWTDVVPGQLGVGLVETKSKIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAX2</accession>
    <name>A0A0B1PAX2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative golgi to endosome transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001239">
        <property type="protein sequence ID" value="KHJ33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAX2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAX2"/>
    <dbReference type="HOGENOM" id="CLU_040577_0_1_1"/>
    <dbReference type="OMA" id="WRQIYKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="509" mass="54536" checksum="497D94E4966432C1" modified="2015-03-04" version="1">MDLTSLKEAAANLTIYDLKAGVRKVQNAVMNYTEMEAKVREATNNEPWGASSSMMQDIANGTYNYQNLNEIMPIIYKRFTEKAADEWRQIYKALQLLEFLIKNGSERVIDDARSHLTLLKMLRQFHYIDQNGKDQGLNVRNRAKELTELLSDVDRIRAERKKARSTKSKYTGMAGGIGSSGGSRLGGFGRNESTSGAAYGSYSGGVYGDGGGYGGQQSGFQDFASYRTPTGGRDRFEEYDEFTEGSSSATRKQKEVSTSSPSRRKTSERIVKKPESVTKSEPEVDLFSFDDVENVTPASVVVPLPTSSLDEEDDFDEFQSAAPSAIASIPSFPSALSTATTTSATQFVSPQPVSAPNAASLSDLATINSIPEIGGVNPSLSKSTALQTTLQQTKSSGFQISQPNYFASVQPLSNNFQSTSSSVTSSKSQVANPASNTTSQVDAFGSLWSSASAGLKKASTPTSSAALGQLAKEKASAGIWSATTNSNASSTPQTSQIRQQSSGLDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB21</accession>
    <name>A0A0B1PB21_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000390">
        <property type="protein sequence ID" value="KHJ35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB21"/>
    <dbReference type="HOGENOM" id="CLU_490191_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="556" mass="64529" checksum="C030CA5E406B7B29" modified="2015-03-04" version="1">MGSRAKHKSKHKLKSKQNISKSKKSGSHKAPKPSTKSFSRGSTPFEASDTRDYSNFEARKSSCHSNFSSKRFPIYIISQDDFKADPTRPIRASRNLGTRSDDLDTLLFQSYIDEILETSNKTKENIKNNIATIPTLLTETAKLEQGLYQILTLDKTHSCEFNEAFQQSSKSVIPEELSITEFSSNTSVLNIAPEEKEQMMQQTTEENLIPYRPETTTPEPSKERIQTEITNTPIAQDDHKKHDANDLSDSSVESMIQKKDDEHNEESIKIKPKRKRANRKKKKKKTKSELLVVEESNKTSSVAIVGTKLNIDVTAEEKDILEILNYYTMKGIREADDDNQYIRLIGYHCFITRILQEKPDVYSSLKLKFDRINSKRLEVHQFMSSHYHFTQAILYCAMLGKTKHGTDKLEEFYYSYIDTKEFKECQDTLESRSNNNIITYYRFMAEQGSLHPTEWYKSLREIYENINKIRPFPGLNRVDEHWSDIAIIFTCSDENIPSNDQYEELLASYLGSERIFQQGSWYFWQSVRRLPWVNPIEIFKINKILATQPNPNELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB62</accession>
    <name>A0A0B1PB62_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000376">
        <property type="protein sequence ID" value="KHJ35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB62"/>
    <dbReference type="HOGENOM" id="CLU_010480_0_1_1"/>
    <dbReference type="OMA" id="HSMHDVD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="834" mass="93902" checksum="F78A828498A0A647" modified="2015-03-04" version="1">MSLDSRGLSRSTTLFSSHGLLPLSLQKVQSFTTGARKPGEGTLCDFSQQDDVKTNEKSGWSGRRKVKKLDVRPVHVETNDEAVEVNRLGRVYKKIIHFSILTRYVVYILPVALLIAIPFIYFAAFRPTDLFVNTGVRVHLFWAWIEITWLSFWGTKLLSKTIPQLFVTLCGVVSSGTRKYAAILRAVETQLNLVSWALISLATFTTFMHPALSNQLHQKHWISVVKNLLGASVVASLLYLGEKMFVQLISINYHRRSFDIRIKDNKHFIRLLSYLYEASRTLFPTNCPEFIQEDSIINNSLKNKLSKASESRSGSATPMRIVGEIGKIGGKMTSAFGNIATEITGKQSYAHQSAHYVVCEALKKVDASEALAKRLWMSFVEEDHEALYSDDIREVLGAARYEIAEECFAVLDEDSNGDVSLEEMIMKVVDIGRERKAIAASMRDVGQALRVLDQVLTTILLVIVILTFVAFQHTTFITTLATAGTTLLSLSFVFAATTQEFLGSCIFLFVKHPYDVGDRCDISNTTLVVERISLLFTVFKRIDTMRMVQIPNMVLNTLWIENTSRSKAMKEQIEIFISFDTPLEDIETLRSLMERFVRHPENSRDFQPEVIMETISVNSMDKLSLKIEIRHKSNWHNENVRAARRSKFMCALVTAIRQVPIYGPGGDGDALGGPKNPRYTVSVTDEWAANAVKESSEAKKSKRLIPLSTESKENSADQTQQKSALDSQLSEEPIKNLSRNNISADIQVSEESNETPETTLREDYQRLENIESLRQGLLKRQSTRGRRRVGEVIPSALQQVSTSTTFNPISAPNVVARQNFDLEKQVGLNSQCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB8</accession>
    <name>A0A0B1PBB8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000780">
        <property type="protein sequence ID" value="KHJ34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB8"/>
    <dbReference type="HOGENOM" id="CLU_007548_1_0_1"/>
    <dbReference type="OMA" id="CFINCAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="193"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="676" mass="76952" checksum="F3107DDCF53ECCAC" modified="2015-03-04" version="1">MVRPGGFVRLNSEDETARFLGPSSGIAMTRLVMEEAKKYTDSRTIRELVPDIRNRRSCRNDSGKGRKKKYPRVSALPAQVLPSLSVTEELLEVFNQKVLAQYLTPTLHEPSLKRDILDVYDGSSDPYQNFVVRIVLSISLQKLDSAYAGLADSYYLAAIEFLEEVIRPKDLKTLQCLVLVAQYSLLTPTQTAIYYIIGLATRICQQLGLTEEKTIAQDVSLGPVDPIQLDLRRRLAWIVLSMEYGLAHSMGRPNSFAPGQDEIGIKFFEPKDDKYITSEGILPGPISEKKVVAIHFLRMRLLQAEIRRKLYQMKRPEPKNENHPWYAEIQQKMKNWVEASPHTPNWSRTWFFGRYQTMIMMLFRPSPQVPQPMKQSAIKCYDAAAINIKSINNQMKTAMVDITWVFVLTIFQALNTILWTISYPEIRALHPKNELEIYVEIALDTISRCQDRWPGTGAAAQLYSKLAQACLRSYDLLGTPNSVSPNASQDDFPLVKSPHISMSDTNLPTGSYHSRVSNRSLDLSREQFNSPCLGEKSIDIKPETSSIDLVEQLSSNPQTSPQTNSAFDIQPLQVDYRFSYFPSENMQFIGLPVTSVTSHQFQPQKHKAQYLNFIDPSYSLYPITCSFDTSMHLNQDFDVKMIPESLSQEQQLELMENLEMNVLDEVGYVMNSSSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBD4</accession>
    <name>A0A0B1PBD4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000348">
        <property type="protein sequence ID" value="KHJ35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBD4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBD4"/>
    <dbReference type="HOGENOM" id="CLU_022048_7_6_1"/>
    <dbReference type="OMA" id="INRRCEA"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="461" mass="52485" checksum="876273483D2B5B27" modified="2015-03-04" version="1">MDFDHTMDDATAALIYELQLQDTAELFHAQNENRELTDSQIAINSYRRELELNYSIISDRIMTRSIAQACRTDGPEVFNLISGGNITEIVEEADSASNSEFDEAEACNIIQIQNTHLQESIGENWEESEDSLDEEPRLYDTLKKKDASPQLNIDLKDHQEIINDSSGRTSPEFDYLRQAVRGKCVEIITGNCASCHETFPSQELAQCPCSHDYCSECLSSLIQNSIKDDGLFPPKCCKQPILLANVNMFLSPELIHSFEAKKIELETQDRTYCSNQACSAFIRTENIEGDRAICLECNTVTCAICKATSHDGDCPADTALQSIIQLAKENGWKRCFNCRCMIELDVGCNHMTCPCGTQFCYVCTERWKTCECPQWDEGLLLTREDDNVNLDPLPEDVIDPIDEIAVAMEDVRRQESCFHGEWQWLRGRYQCQECFHQLPSYIFECGLCSYRACNRCRRNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBJ4</accession>
    <name>A0A0B1PBJ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000151">
        <property type="protein sequence ID" value="KHJ36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBJ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBJ4"/>
    <dbReference type="HOGENOM" id="CLU_051199_2_0_1"/>
    <dbReference type="OMA" id="HVECMNR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062023" evidence="2">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34425" checksum="0E93DB7669AFD10E" modified="2015-03-04" version="1">MRWTTKSNWQISWIFVWLSILSLGIVTEAEEHNNIPLPSYHYGAMIPVSCLNRSIDTGEHITDDKNQLQYIPFPVCNETGLSLHLRYGVEEELNCTIPMVTDSFFHLLEFYVHNDVPLSCHIPSRPATHNNALSDEKQNLGAPSSYQQEFVPLIFALAGTLQLSHLHVSTHLNILIHSTPKHHLHHHDSGVIDSGAAYSTSPLSHTTGPVALTKKLVIGDPLPLMLSVRWFPTPYLPRENGKIEWAGMKGHFTATTFFYCITSALAGAIGSGAWFFGVVLPRRLRGRARLGGATPLGYGVSKRWGIGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBM4</accession>
    <name>A0A0B1PBM4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000944">
        <property type="protein sequence ID" value="KHJ34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBM4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBM4"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="LMIDMIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="36130" checksum="5D3AAA74FA915411" modified="2015-03-04" version="1">MQSSTYDPCLLITEGDILGLVGMQTDDTLILGDELFSELEERKLQFTAKPKQKLTRDKPLIFNGCILTLNDDFSIHMTQKNQGKKIDLVEDTDSKVYVQQRARGAYIASICQPEACYDLSVAAQTKNPSKDDLSKLNKRLQWQKNDLDRGLNNVVLNLRHAKLFIFVDASFANNEDLSSQIGYIIVIANETNQEDHKFAITEIYGMVGGVDMGYAIATTINLIFSQLDLPEIPIIVCTDSYSLYECIVKLGTTKEKRLMIDIMALRQSYERRELYEIRWINGADNPGDAMTKANPNKALETLIDTNSLDIRIEGWVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBM5</accession>
    <name>A0A0B1PBM5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1166</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01000312">
        <property type="protein sequence ID" value="KHJ35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBM5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBM5"/>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="416"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="928" mass="104254" checksum="6D43C662BB2D9710" modified="2015-03-04" version="1">MSGARSFGLERPDGEEAPASRLVLFVADGLRADKTFQSFPEPYPKTNEDLIPRPLTPFLRSRILEHGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVTTGWKLNPVNFDSVFNKSQHTWSWGSPDILPMFQLGALPGRVDAYSYPAEDEDSSQDAVQLDTWVFNQVDNFFLGAMRNKTLDAQLRQKRVIFFLHLLGLDTNGHAHRPYSKEYLSNIKVVDEGIKKTTEIIEKYYNDSKTAFVFTADHGMSDWGSHGDGNPDNTRTPLIAWGSGIARPVKYSGKTAPGHDKFSSDWSLNHIQRHDVSQADIAALMAYVAGLDFPVNSVGKLPLEFLSANLSVKSEAFLTNTRGILEMYRAKEEQKKKNEIRYRPFKAFAGSNQSVDHRISIIRALIDQDKHKEAIENTAALFNDALQGLRYLQTYDWLFLRALITIGYLGWIAFALSIVIDLHVLHGKTQVSRTIFSNTAFSSVLLLLYSSFIISKSPYTYYAYAIFPVAFWEEVYARRTILIEVKNLLFENLKPDSSIILLSLKATVGLALIESLALGYSFRGVFSVLFIFGSLWPSIYGFDFVARNKELVTTWMLNCILMSSFTLFPPIKVENLKLIMTSGLLMFIIGTSYLIYENRILPRKMKPVILSRSLIGIQIGFILLAMIVTYSSVLSLQAKSGLPRGNQILGWAVIVLPLLMPLLHRLQPNSHYLHRLLVIFLTFSPTFVILTISYEGLFYIGFCTILVTWVRLESAVFSFTQYKINPKNSSAIASDPNTSTKFRSLKFSDFRVSLFFLTLLQSAFFSTGNIASISAFSLDSVYRLVPIFDPFSQGALLMFKLMIPFAVISANVSILNKMLGVPPSALIMVVIAISDFITLHFFWVVKDEGSWLEIGTSISHFCIASLLCMFVAGLEGVGEIMTWGVEVEEREFLKKSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU3</accession>
    <name>A0A0B1PBU3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative golgi matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000122">
        <property type="protein sequence ID" value="KHJ36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU3"/>
    <dbReference type="HOGENOM" id="CLU_020680_1_1_1"/>
    <dbReference type="OMA" id="QAMHNWE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="453"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="178"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="563" mass="64291" checksum="02661FC5F7E5FB7B" modified="2015-03-04" version="1">MSSVTPTQSSENSTTNSKAKNSKKKKISGQKTNGFPVNKSTEITINSSKNGKNGNPKDEKVEGMKEAPKSHNLLDDGDLLAENDALPSPTDPKEMSSKTETLCSKKADACMTFEAMSYQRESLLAEVEQFRKSLEDIQDRHLSDLNTIKCQHVEEITNLKSKYDEEISMIHKKHIDEITTLKTELEESTAAKDVAETQYQNLLERVNTIKSSLGERFKADKQELAEAKTQIEDLEAQRDSYNERVIELEVELKSLDHERQVSLDEIISLQNKLNISQSSLSLLQEDLANQTRQLKDEVIAANEATNAWQMLAKEERSIREGLEDRIKYLEEQISSDREALDLAVLQRDTYLENLEALRKNIIDIQEAQKTELKQMVESYESQLRNLEKIVQREEARACEADTSRCSLQVELERLLPIEKEVKEKNLLIGKLRHEAIVLNDHLTKALRFLKKAKPEDNIDRQIVTNHFLHFLTLDRSDPKKFQVLQLIASLLNWTDEQKEQAGLARPGTSNLSQRLPPANFNRTPSMQSLSLEFSNEAPVKRESLSDLWKGFLERSAEESKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCC1</accession>
    <name>A0A0B1PCC1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tyrosine protein phosphatase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000210">
        <property type="protein sequence ID" value="KHJ35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCC1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCC1"/>
    <dbReference type="HOGENOM" id="CLU_049471_1_0_1"/>
    <dbReference type="OMA" id="IAYIMVM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="294" mass="33274" checksum="8FB43719EE9A9D0D" modified="2015-03-04" version="1">MSHVSHVIGVARNEDYAFRAPSPPHIYIPQAPDEYDVLIPPFCGIWCENEQFLKFIQEIIQKSSHSISNQEWKYEWRRQAQQILPFLYLGPSSAARDIDFLKRENMTMLLVIRDSAIARAKLLDGAKIARQLDIKSRTIDVSGLTGLIAAFPHAIQVINDHLISIFQESSSTKIGKVLVFCESGNERSAAVVSAYLMATCGLDLISSIHRIQSRRFCISLDDSLKNLLLNYMDILNAKKDVSSVKSRIPNSIRNLMSGKKRRRNEDTDEEGTAAMEICSDEERFLGRTDLAPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCF6</accession>
    <name>A0A0B1PCF6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000556">
        <property type="protein sequence ID" value="KHJ35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCF6"/>
    <dbReference type="HOGENOM" id="CLU_139267_0_0_1"/>
    <dbReference type="OMA" id="YLKGTIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21701" checksum="DCC1B478E6E77F6E" modified="2015-03-04" version="1">MVREIKGKNENPYEKSRLVIAVIAACLQNSVKLKLRDITQVYLQSRTVVQRYILAQLPPQLQQKFLPDTTLHVIKPLYGVAESGVHWFTTYQKHHIEKLNMVTSTYDPCLLITKSDSIDSRFGIVGMQTDDTLIVANSEFSAKEQEKIEKAKFDTKAKQTLSSDMPLNFNGYTVAIDSSIGSIKMYQKGQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCG9</accession>
    <name>A0A0B1PCG9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ydr124wp-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000554">
        <property type="protein sequence ID" value="KHJ35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCG9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCG9"/>
    <dbReference type="HOGENOM" id="CLU_021647_0_0_1"/>
    <dbReference type="OMA" id="MQQSSCK"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="210"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="605" mass="68704" checksum="908E893E03D2A1AC" modified="2015-03-04" version="1">MVQNVPLPRDDDCWGRNEKSFDVSQDVVAAESHSTIPNLNRNNVRSQSMSDYQPHIDPNEQQSTAIKSALLNCGHDVAEFILIYTGSDGNPHPTVISSSGLRNYSHRIANEHVCYNFTRSILHSRNDMVLVSPDDPRSISQFDTESRIQSPWDQKLISPSDYRVGTEDSDEDRSPRSRKRARARARVRRLRQGLTEDQPLSSVKSQKLTIGNEADVDRFYYIRFKDMQQSSCKVMGKAFVKLVEPRKQTHHPYTGGNEKAPSWWPPTKGDNAVRHKEPDHLLKPERISLLVHILKMIIEPAERQNPTIRKLGLNVKKLEETTMEVMSNWFNDKEHPENLLKKKYLKEIFRVAKIQERYKRGEIDGATAVSITCGIENYGQDGSDEEEDNSFIPNSEVDSSEALHSIAITGVHSPESILTHPSLQQSDNEIRLPSQGLRQNLQRSSIHTSTYDSQLFRLDPTSFQTPQPRIPNLHDPTRRSYTQSGFGSPQSSLTSPWPATPLINSPPQNSIFFSQPTNSFTYLSSPQQQHHIHSTHHGLEGLHIGNLTSNRSFDTGNTFNCQQPQRTGNLSPPLTYPPQTHPHVPYSYNQGTSMYAHENDIKPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCI5</accession>
    <name>A0A0B1PCI5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000927">
        <property type="protein sequence ID" value="KHJ34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCI5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCI5"/>
    <dbReference type="HOGENOM" id="CLU_424011_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="646" mass="72462" checksum="D125283A8112CF19" modified="2015-03-04" version="1">MVSSTDKDLFTCNGCGDDIGSERARILCNICVDFNLCSNCYVLNYASKTHKKSHSTSVFRTSGYVNSENSNALTLLQTENSGGNLRKPSQENERKYSEIPTANWGALWNVMKAPLTKKDKRASKSTGKPESGTSLEARNKNDSLSPLSRVPEPLSSLSVSTKSQVTPVYPGPTYFRPDKWEPFFESDNTPSSIFVGLMSSIFNTLDEKGTGYLKPEEFSFFLEIQGYPLSANIWKMAWQKAAGGSSKDVADLELGLYFAEREIPFTLAARPIELETSGGNSPEKPLNSKTKKKNSKDVNKNMPLLSRQGFIDLSASEYLKDPSMAYQYIMNALHELKVWKELGDLPRSVLPIFPMNNQVQDQEEEEEEEEEEEEEEEEEEEEDSDISILIPNSKENESSESENENHQLNENQELILLNIDKEGTKSESSNINTSENEPLTPVSIDKSVATPIVENTGNQGLTAQHLRISADEPMTSLFIGKPGFSLSDGDRMDQKSAFQHRNNSENESMSPTFVKKSELTLTGEDKKNQKSSFQHLKTSVKEPLSPRFVVKFQDNSCEPTVNLNTKIIDPKNMKSSRLLQNKHKLVVKTDFPNQWLSTASALSARSPQRRKVEMLVEAYEFVRANSICLDERPVFKSASIYKNTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP8</accession>
    <name>A0A0B1PCP8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP8"/>
    <dbReference type="HOGENOM" id="CLU_1636668_0_0_1"/>
    <dbReference type="OMA" id="NDAFCEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="18779" checksum="4BB4C4012FA54BF2" modified="2015-03-04" version="1">MHTPPWRPASILDEWVRRQARPVSIKQLEVFGRHLTESRIIDSAKYVQTELPTRLAHRIRDMQTLPYVVVANPHISQVYELYYKAFEAIRGIGEIKNLNDNQRLCKKISETLHEHLTVIPKLTMGILECRDLMRPEDMDSFMNTILPNLSSFNCSTSSCSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCT1</accession>
    <name>A0A0B1PCT1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative related to aga1 a-agglutinin anchor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000858">
        <property type="protein sequence ID" value="KHJ34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCT1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCT1"/>
    <dbReference type="HOGENOM" id="CLU_030105_1_0_1"/>
    <dbReference type="OMA" id="WKDECAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="54037" checksum="363EFD07C10700C8" modified="2015-03-04" version="1">MPPFPSRSRSVRRPISRVALAPNDSSAASSSVSTAIKSNTGASESEKKHDLSPSRLPIKPTQSSSRTKSSKDDSLQPHLPPEPGSNAITTSNAPSLDIQRSASNRQSKKLTSSEIEPIRKDRSRPPVATVSRHLRHNSSNSSTGRVRDPSKGRERSSSTLPSSSYSRPPTRNSVSSNVSERVSTYVSEREPLKKPAFSTHQQHYTPAKNIAPKLHPAVFLAPPTPSKWPSNKVISAETSKLQNELLQLHLLHRDYGLTEREWRASAKSKLETRFQNMVEMEHSILELENFEDFRLNSIALEEWPDVGTSGWGLDEKKHIFENILIGLMSTRDPGGRYARVTQNFEDWVDTYEQTMERREKEDEDYSDLLLVKELDSTWREDCFYLERKLELWKDNIRDLGIPQSESSLELVVDQVQRIILGMLVELDSMMRLEREVKRREEHWIKAKNDEMLENVTKDNALVAGAIWRSIGVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCU8</accession>
    <name>A0A0B1PCU8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nuclear segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000849">
        <property type="protein sequence ID" value="KHJ34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCU8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCU8"/>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="57588" checksum="3AB68B10E927DEA9" modified="2015-03-04" version="1">MTTQALNELKLPVRPEKPDEEVYKARLKKAEKEHSDSVLKFNVVKNKLENAISSSSDSPLAKRRTELINQLKDIREKQNSGTSSRNKILDQIKREDAHIKELLSQQKTARTRVNFKSVDDLEREIDRLHKQINTGTMKIVDEKKALDTISLLHKQRKNFSGFEESQKNIDAKRKVIKQLREQLEDPESKALSEKYNKIQAELDAVKAEQDEMYNNISNLRDEKKKLQNIQQTKFLAMKEIKDNYYEQNQAVQKWEYEARQRARERKKAEEERFQLEKKKARAQQILDEASDKAYLEEIRRAHSLLRFLDPSYLSEKPPPLKTTSKLHALPMRQIDIPEIKGVRIAKKEVDDYFPGTGGKKGKKAKKLASKETSVPTKYSCPPAVMEDCAFLEIDPPMSSADIPTVKDKVLAKLNYWKTNQEVETERNIANARKEVERLETEQSLSLNSPTSEQSTKDNSVNNKTTTLNIKNEDLKSKVLEQNTQPDVETKKQDISLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD1</accession>
    <name>A0A0B1PDD1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g1787</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the large ribosomal subunit. Interacts with DHX33.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD1"/>
    <dbReference type="STRING" id="52586.A0A0B1PDD1"/>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 17 18" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ36248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="392" mass="44392" checksum="C10632E8BF552D2F" modified="2015-03-04" version="1">MSHRKFEAPRHGSLAFLPRKRAARHRGKVKSFPKDDPKKPVHLTATLGYKAGMTTIVRDLDRPGAKTNKKEVVEAVTVIETPPVIVVGLVGYIETPRGLRSLTTIWAEHLSDEVKRRFYKNWYRSKKKAFTKYAKKHSENGAITIKRDLERITKYCTVIRVLAHTQISKTPLKQKKAHLMEIQVNGGSVADKVNYAYGLFEKPVDIGSIFEQDEMIDVIAVTKGHGFTGVTSRWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQDGYHHRTSVNHKVYRIGKGDDEGNASTEFDISKKQITPMGGFVRYGRVKNDFIIVKGSTPGVKKRVMTLRKSMFIHTSRKALEKVELKWIDTSSKFGHGAYQTPQEKRQFLGTLKKDLQPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEH8</accession>
    <name>A0A0B1PEH8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ras gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000556">
        <property type="protein sequence ID" value="KHJ35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PEH8"/>
    <dbReference type="HOGENOM" id="CLU_000972_1_0_1"/>
    <dbReference type="OMA" id="RELMCPE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="264"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="864"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1479" mass="172112" checksum="22B185B4CB87B072" modified="2015-03-04" version="1">MNDPLITHHLHPLRQTHNLDYSATTTRKSSSSSIQSSVFSNSASGFDRFHTSIHSPNSSLGSSYRDSVSETRDLSAMLNENWNSSYDSLPIRTYNSMKHSAYSPLQNKTPSISNDMKINYSPAQSEGLSERPKKNSRTNSNLYKSESSILSRANSICQRSSLLHSNSIHHLQSSIRAPDLHSLQKSSTSQLRTLSKFAKDITSDYFNIFSPTQKVAGLYGRRKLQKSNTAKVNRSLPSNRRLYEWKTRNWMDSERQFLQAYEYFCHISEAKEWIEKVLQRPIPPIVQLEEVLRDGVTLAEIVVTLRPDKKIRIFRHPKLQYRHSDNIATFFRFLADVELPDLFRFELTDLYEKKNTPKVIYCIHALSWLLYRNNTVDFPIGNLLGQLEFEHHELEEMQKGLEKAGVSMPSFENMGADFGLNSVPNSEFEQIKSEEDLIRSKLEKNLPIIIDLQAQAREAMNRLQLGEIMHQLWDSEETLIYFQSIIRGDFARQVINYRISMRRFSTSLQSIVRGFLTRHRWAGQNFFWKEDEEKLITLQNLIRSKTVRSKLDRVQLQLVKSKDNTSQFQAQIRGFLIQRSLTAQLNEAKICLCSISYLQAAIRGMSSRRICAKNYQILSDETISIKTIQASARAVIVRRNLSDLKAQLREISPVYISIQSILRGNQSRQQFQLSAAQASLIRLKFEEKLRYFMENMEKVVKIQSFVRSRLQGEAYKILTTGKNPPVNTVKNFVHLLNDSDFDFNEEIEFERLRKTVVQQVRQNEMAEQYIDQLDIKIALLVKNKITLYEVVRHQKNFGGHPSNLLNTTMVSGSQFDLKALNKSSRKKLESYQQLFFTLQTQPHYLARLFKHIRQQGTAEIDCNRIETLMMVLFGYAQKRREEYYLLKLMTRSAKEEVDSAVSIKESLRGNFIWTRILANYTRSPRDRRFLRELLGPFIQASIIGDPTLDLESDPMQIYCSVISNEELRTGQASHRPIDITREQAIKDTETRELFINHLRDLREIVDDFLLSLESLVNKMPYGIRFVCQQIFQAIFQRFSCESQQLLLQTVGNWLWKIYLQLAFLAPVITGIIERQMTPLLKRILSEIAKVLNQISSGRLFGGENIYLQPLNAYMENAIERVTAIFANIISVSDAESTFDIDEFNDLYAKVKPTLYIKMDDIFAIHKLIEADLPHICQNKDDLLRDIIHELGSAKNNENEMLGVSSIEILMKLNPKLHDIEDPEADIKELFMETKRCVLYIIRVQTGSNLMEILIRPITPEDEIKWNSVIIEEFSVENRARGAYSDINSLVDIKSMSYKDLKRTALENVLKLEQLGRISRQNFYQDILNAIALDIRNKSRRRVQRHRELEGVRLTLANSNEEAEWLESQRKSYDNYIEQAMISLQKKGKNLFLMPFSKQYNHERELERSGRKPKFGSFKYSTHTLFDKGVLVSWKGYTDRDWDKTNILISRDEVEFFSLKAAKEVFKFLESVLKYLWNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEJ3</accession>
    <name>A0A0B1PEJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nadh-ubiquinone oxidoreductase 49 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000283">
        <property type="protein sequence ID" value="KHJ35740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PEJ3"/>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="195"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="465" mass="52934" checksum="47B20D74B7CF8E4A" modified="2015-03-04" version="1">MATISKHARFLMKDLWTKNISFKTTTRLFTSCKLRRYAESYQATKLIPTNESFTNLKDQGSLQKSEIFSDEDAVENRKIRHYTVNFGPQHPAAHGVLRLILELNGEEIVRSDPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEIPERAKWIRTMFAEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHSAYIRPGGVHQDIPVGLLDDIYQWATQFGDRIDETEELLTDNRIWIGRTKGIGVVSAADALNLSFTGVMLRGSGIPWDVRKSQPYDAYGDVEFDVPVGVNGDCYDRYLCRMEEFRQSLRIIHQCLNKMPPGPVRVEDYKISPPPRAAMKENMEALIHHFLLYTKGYAVPPGETYSAIEAPKGEMGVYLVSDGSERPYRCKIRAPGFAHLGGFDQIARGHLLADAVAVIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEL2</accession>
    <name>A0A0B1PEL2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sister chromatid separation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEL2"/>
    <dbReference type="STRING" id="52586.A0A0B1PEL2"/>
    <dbReference type="HOGENOM" id="CLU_010838_2_0_1"/>
    <dbReference type="OMA" id="KWECGEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="10">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="325"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="654" mass="74590" checksum="C1F9AD2B8AAC05E4" modified="2015-03-04" version="1">MSDTDSYDYLQPNFEPTSLTVPRLRSILVNYNISYPSTAKKAQLIKIFIEQVLPQREKILKERERARRSSRGIVNANSRESFDTEEPIALSSRPSRRNTRNLSARLKVDELEDEEVGYRKEKTRSPVKKTPRASSKHARVSDTETGLDQDTRRKSLRSKKSETPSHHQVDYVEVNHETPDKLPREKVEEQQDSAFTYDNPFQSGSSPLFGKSNEARRKSQGINKERKKTFNSVRRRRTETPQITDEICPPSSTIFEIPITSNILSAPTAFEKLHENVIETGEEFTPEEQSELIQERSIVNESLGSLRKKSKPINGFSFVGPFWVLILTTLIGYSIWYRQEKIAIGYCGLGKSAMPLISTSKEIPTWARILIEPECEPCPRHAQCYERMEAKCERDYLLKPHPLSLAGLVPLAPTCEPDGVKVRNYKAVADRAVEALRLQKAKFECGAIDDTGATILSPEINADDLKKEISKTRRKDISELEFEKMWTGGIEEMKTRNEVQTRIDGNHLKLSSNSLAGLPISCALKRSICNTLGQYRFEIGGLIIIMLSLLKLRSLIISKRKVNAAIPSLVSTTLERLTKQALLHQENKNIDPWISIGQLRDDVLRNEHSIYKRETVWRMVRIVIETNANVRSSQKENRNGEVSRVWEWIGALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEX9</accession>
    <name>A0A0B1PEX9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">EV44_g0708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000488">
        <property type="protein sequence ID" value="KHJ35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEX9"/>
    <dbReference type="SMR" id="A0A0B1PEX9"/>
    <dbReference type="STRING" id="52586.A0A0B1PEX9"/>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="159"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="776" mass="87380" checksum="B2041E0A7FF9AED8" modified="2015-03-04" version="1">MVFSNGKMKRKADSVENTAGVGTDTESESVRLEGIFSQSEDENSENLEDNDDYRSSNFEISDGVSDDEIDYNKESSSVNRNEDNIASSTTNGTTSFGKQMTQETKTLDTDGHIPNYIVEKDANGEQRYVYDEIEPGYDSDDSDAHVNINTIGNIPLSFYDTYPHIGYDINGKRVMRPAKGEALDALLDSIELPKGWTGITDPATGKPLQLSQDELEILRKIQMNEVPGDGYDPYPATIEYFTSVEEIMPLSAAPEPKQRFIPSKYEAKKIMKIVRAIREGRILPYQPLEEREKDEEKIFFDLWKDEKSLPDNVMNIPAPKLAPPGYDLSYNPPPEYLPSKTEKEAWESTEPDDREREYLPTKYDSLRKVPAYNNFVKERFERCLDLYLAPRVRKNRLNIDPTSLLPKLPKPEELRPFPSICSTIFCGHSGRVRSLEVDPSGVWLASGGDDGTIRIWELLTGRQIWHTKIDNDEPVNVVRWRPGSSAVVLLAAVGESIFVIVPPIIDPETEVVSRDLVNSGFGYAKNLSPTATSNGTRKEPAAKWARPGMRLENEGVILRITTRNIIKVISWHRRGDFFTSVSPTAQKSAVAIHTLSKHLTQIPFRRLPGIPQTAQFHPSRPILFVATQQAIRSYDLQKQELLKILQPGARWISSIDVHPGGDNIIVGSYDRRLLWHDLDLSTRPYKTLRFHSKAIRAVKFHKGGIPLFADASDDGSLQIFHGKVVNDMMENATIVPLKVLKGHKVKNALGVMDIDWHPSEPWCVSAGADGTCRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF00</accession>
    <name>A0A0B1PF00_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative areb gata transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000213">
        <property type="protein sequence ID" value="KHJ35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF00"/>
    <dbReference type="STRING" id="52586.A0A0B1PF00"/>
    <dbReference type="HOGENOM" id="CLU_035349_2_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asd-4/GZF3-like helical region" evidence="3">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="215" mass="24300" checksum="2C9BCA73FBD63F05" modified="2015-03-04" version="1">MVSHYENIEHARSQIEAQASTVGPLSLRRNSQRSIKRNPDGSMSPISRHSTPSRFCGPLSSYGNYQLDDSYTHHSPLQPTLHLHHTSPGRSISPINGKNGNGAYQSYDQLVAQNSSLKTRVSELEVINELFRGRVAQLEQDESMARRGEQVNRDIVDDLTRKLEESQRRENQLKRRLDDVEQELIQVKDGTSHVKKIRVSDMVANNEASTTEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH22</accession>
    <name>A0A0B1PH22_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mitotic spindle assembly checkpoint protein mad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000255">
        <property type="protein sequence ID" value="KHJ35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH22"/>
    <dbReference type="STRING" id="52586.A0A0B1PH22"/>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905318">
        <property type="term" value="P:meiosis I spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25492" checksum="C1264347998D3668" modified="2015-03-04" version="1">MKGEQVKNKSKVHKLSLRGSSKLVAEFFHYSINTILFQRGVYPAEDFTAVKKYGLTMLVSSDDQVKGYIKKIMSQLDKWMIGNKISKMVLVITSKDTGEHLERWQFDVHIPANVRGEKDFNSKPYNENDINNSFAPIEKTESEIQSEIQSIFRQITASVTFLPELPGDCTFNILVYANMDSDVPIEWEDSDAKEIKNGERVQLRSFSTANHKVDTLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH37</accession>
    <name>A0A0B1PH37_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000246">
        <property type="protein sequence ID" value="KHJ35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH37"/>
    <dbReference type="STRING" id="52586.A0A0B1PH37"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="23312" checksum="B39DB364EB1EC042" modified="2015-03-04" version="1">MAQTAVSYSHPLKKFKLVFLGEQSVGKTSLITRFMYDTFDNMYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFHNTRKWIDDVRGERGNDVIIVLVGNKTDLNDKREVTVAQGEEEAKKNNLMFIETSAKLGHNVKSMFRKIAQALPGINSVEGSSSLGNQVIDVNINPTQSSQDGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI99</accession>
    <name>A0A0B1PI99_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g5530</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01000109">
        <property type="protein sequence ID" value="KHJ36209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI99"/>
    <dbReference type="STRING" id="52586.A0A0B1PI99"/>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="OMA" id="ENHSKGP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="60"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ36209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="635" mass="73246" checksum="674BA9D1317B444A" modified="2015-03-04" version="1">MFRVKTRLGRPSFYGNSFTKIHYFPNVSFMAPATERTNSSISSGLPRQRMLQYEDSLPKLPVPSLEETAARYLKSVHPLLSKNDYEFTTKAVQEFIKPGGAGHKLQARLIARREDPKVKNWLYEWWNDTAYLSYRDPVVPYVSYFYSHKDDRQRRDPSKRAAALSTAVLEFKKQVDEGNLEPEYMRKSPISMESYQWMFNACRIPKKPADEPIKYPCNLHKHILVIRKNQFFKVDHELDGKLLNTSELEYQFKKIYEKAERAPAVGALTSENRDVWTEVRNMLLNVHPLNAEALKIIESASFVVCLDDSRPVTLEERAHQYWHGDGRNRWFDKPLQFIINDNGTSGFMGEHSMMDGTPTHRLNDYINSVIFNNKLDFSNKDVRSHIPEPSLVKFRLSKDIYTEIERAQKDFAQKIDQHDLSVQAYQAYGKNLIKRFKFSPDAYVQMIIQLAYFKMFGKNRPTYESAATRRFQQGRTETCRSVSDESVAFCKAISSSNFNAEEVFKLFGEAIKAHVEYISAASDGKGVDRHLFGLKKLIAPGEDVPVIYKDPAYNYSCTWFISTSQLSSEYFNGYGWSQVTDDGWGIAYMINENSIQFNVVSKGLGSERMSFYLNEAAGDIRDLLLPTLEPIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIM1</accession>
    <name>A0A0B1PIM1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIM1"/>
    <dbReference type="STRING" id="52586.A0A0B1PIM1"/>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="OMA" id="GFKTWLF"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="59142" checksum="D573695854C89874" modified="2015-03-04" version="1">MAPKALSVNGSESEFEFIETPKAPTPTFEKFEDCGVRTTSYPAIKNAPLPVDGPGSDSFSNIVLLSILVGAPTYFSWKIGGGLKTSLFFGLFTTPVILPFFWYLFSSYSPRKNYKVKVPGNPTEHYITFKDPAHAAKYSGNKKIPMETFHNMYFDELVDFNGDCLEVMEYRHDWASFRFTLSLYHFLLFQFIPEVLMHTRSQDEEQVRNHYDRGDDFYGWFLGVRMIYTSGIISDINKEETLEQLQDNKLAIVCEKIDLQKDDNLLDIGCGWGTLIKFASVNYGAKCTGITLGRNQTSWGNNGLKKAGISAEQSKILCLDYRDIPVPEGKYSKITCLEMAEHVGIRHLPSFLRQVYDMLDDDGIFFLQVAGLRKSWQYEDLVWGLFMNKYIFPGADASTPLKDWIGALESAGFEIKAVDTIGVHYSATLWRWYRNWIANKEKVIAKYGKRWYRIWEYFLAYSTIISRQGSATCYQITLVKNINSTHRVEGIKTQFSLSGALQSCRENKKADFPKNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIR1</accession>
    <name>A0A0B1PIR1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transcriptional regulatory protein dep1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000049">
        <property type="protein sequence ID" value="KHJ36369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIR1"/>
    <dbReference type="STRING" id="52586.A0A0B1PIR1"/>
    <dbReference type="HOGENOM" id="CLU_012439_1_0_1"/>
    <dbReference type="OMA" id="IQNETHE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="659" mass="73475" checksum="DC221227DB250E7D" modified="2015-03-04" version="1">MDKIEDEITQAYNLVVSPSNLPSNVDADSSSNLSELEDKSARDLGEDIVANNRDDEVAIDRSEILSNVSDGINDSEAETVHMEESSVKPLSPTDSNLAPSTKFSYNKITSYELRGFAVENLQGDEGEEAHTSDKVLVDEFLDSARNSIPNEADNINLEDPNTSITFEVENKEVISKVSSDSRKRKRSILGVTVLGEINEPLRKRTGSILAGCNGYFNEDEIAIEEISSNFVAENHSAGEERGAPGEESTEDAEEDAEKLNIATETPDTGSSSCKIGQKKKILYKPNVLNNEEDAENTVDQDSIVLGLNPKTQEVDMPINEEDENDVAIRNDEAIERKRNALDRLSGIERQFSIFRERLYEERLKHLNDEDDMLRQPQPSHPEYLAWLQCIDARRDERIRIAEKQYSYKLQCLKKVAVAQRSQILAQYQQEIRGVREHKLEQLGEQWYKIQHDRRNSTGICPEFSLRFPRKRSQQLLNHIAYCNEVSILSGVAKYVGFPAAPIMAPASAIELEEDLEKIGRSKRNSQAPPPVSFHDLVALRAISSSFKIQTPRRKASPRYGGQKCGNSSNSYTCHQITGMDGTCPQKDSVETPDLVQKIPQTCQASRQASVSPHSGQALANIPDSIHLSKTQAIHNIKSSTISPVATVNIDLLHESRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWF2</accession>
    <name>A0A0B1NWF2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003741">
        <property type="protein sequence ID" value="KHJ30702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWF2"/>
    <dbReference type="STRING" id="52586.A0A0B1NWF2"/>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="OMA" id="SKCTIQP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="285" mass="31863" checksum="817DB5F470487DD6" modified="2015-03-04" version="1">MSPFIYYLGLGIASYTFLTIILYLLSKIIPIAGFFARLLAAYASLVFCASVGVVSSIILRLAGYQRISQWFVARCFKYTMWYTTGITFIIDDPNDYLNKTRPAIFIGNHQTELDVLMLGCIFPKWCSVTAKKSLKRVPFLGWFMALSGSVFIDRGNSINARQAMSGATDEITRERQSVYMFPEGTRSYARGPKLLPFKKGAFHLAVQAGVPIVPVVVANYSHILSPRTLTFKAGKIPIRVLQPIDTKNLTSADVDDLTRETQAKMLEELIQLTTEVQTQHVSVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX15</accession>
    <name>A0A0B1NX15_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative autophagy-related protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003476">
        <property type="protein sequence ID" value="KHJ30902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX15"/>
    <dbReference type="STRING" id="52586.A0A0B1NX15"/>
    <dbReference type="HOGENOM" id="CLU_520916_0_0_1"/>
    <dbReference type="OMA" id="HWNLLIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="523" mass="59591" checksum="4299A51DE2BDA02B" modified="2015-03-04" version="1">MSRSSFARLSSSRSLLSDENSYNLNDIAPSEETTGLPFEKSSFFHTSNAKDHSNIPDRCSDGLSNQPHSDSEISEQPKRARTPPSITRSVLLRKPISQSTIMPISFRDRNTKTDELLALHRREKAIQADIQHLIDAHFAALLLGYNDKGENLSEVSSRSTDKKLEKAGFPKVIPVRQPKKHPTGLREARDGLATKMEELIYVKREELIIYEYEISKRGEAISIADNWQTKLIKLNEQLSSYSSDGNTEPRGDKGTDDDFTRLMEEEKTVLTKIRLLEDKLSQLKARRESIRRRIDESANKKEARLSSYRGALWNAEAEIKEFLKNPPVSNSLVKGDENSFTSVPVSKRSLVMAIECWKKELSQAILLKQKAEIEEEALEEGILIWEASIQIIIDLERDMRRKLKCERMKNIADFKDQIMKMNSIITKLEENLHTATSKGWNLLICAIGAELEALERGKNILNKSVAMSENTISLENIQLNSTPTNQFFYNIDGDEDIRLSLERKLTEEAPEKSSFHSHIRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXB3</accession>
    <name>A0A0B1NXB3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g1110</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003318">
        <property type="protein sequence ID" value="KHJ31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXB3"/>
    <dbReference type="STRING" id="52586.A0A0B1NXB3"/>
    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
    <dbReference type="OMA" id="HMLRYQA"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="18">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="660" mass="72030" checksum="656971CFECF9EF3E" modified="2015-03-04" version="1">MPSATPNDTTKVGQSANDNICRFAAPSRPLSPHATHTLFHDKTRCFVYGLQPRAVQGMLDFDFICKRSTPSVAGIIYTFGGQFVSKMYWGTSETLLPVYQDVEKAMAKHPDVDTIVNFASSRSVYSSTLELMEYPQIKSIAIIAEGVPERRAREILHIAKKKKITIIGPATVGGIKPGSFKIGNTGGMMDNIVASKLYRKGSVGYVSKSGGMSNELNNIIANTTDGVYEGVAIGGDRYPGTTFIDHLLRYQADPECKILLLLGEVGGVEEYRVIEAVKKGIITKPIVAWAIGTCASMFKTEVQFGHAGSFANSQLETAAVKNTSMRDAGFFVPKTFEDLPSTLASVYDKLVKDGTIKPQPEPAVPKIPLDYSWAQELGLIRKPAAFISTISDDRGQELLYAGMPISDVFREEIGIGGVMSLLWFRRRLPDYASKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISALVSGLLTIGSRFGGALDGAADEFTTAFDKGLSPRDFVDSMRKQNKLIPGIGHKVKSRNNPDLRVELVKEFVKKRFPSCKMLDYALAVESVTTSKKDNLILNVDGVVAVCFVDLMRNCGAFSAEEAEDYLRMGVLNGLFVLGRSIGLIAHYLDQKRLRTGLYRHPWDDITYLLPSLGSGPGLGTQGRVEVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXQ3</accession>
    <name>A0A0B1NXQ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003160">
        <property type="protein sequence ID" value="KHJ31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXQ3"/>
    <dbReference type="STRING" id="52586.A0A0B1NXQ3"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="246" mass="27567" checksum="87BCAFA6324946D1" modified="2015-03-04" version="1">MDNKSDIKPQYISQRALGAYIATVCQPEASFDLSRAAQTVSPGINEAALLNKRLKWQKINSRRGLKFIKLDNKSLKIIVFTDGSFANNKENMTSQIGYVICLADDKNRANIVHWSSTKCKRITRSVLASELYAMVVGFDMVTIIKSTLEKVINLLSISKSSSSIPLILCTDSRSLYECLSKLGTTTEKRLMIDIMALRQSYDYNEVAEIRWIEGSKNPADAMTKHNPCDALRKLIDKNEVDMSANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY89</accession>
    <name>A0A0B1NY89_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003006">
        <property type="protein sequence ID" value="KHJ31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY89"/>
    <dbReference type="STRING" id="52586.A0A0B1NY89"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OMA" id="ADLHTWH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="130" mass="14550" checksum="7D37F1E7824DAA5E" modified="2015-03-04" version="1">MAGNAQKRIAKELAEISQNSPAGMQGGNFELLLTLPSDYPFKPPKLSFKTRIYHPNVTFDEQGSMCIGALKPDAWKPSSRIINILMATQQMLTEPVLDDAVETALADRYRNNRNEFNEEAAKATKKYAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYX4</accession>
    <name>A0A0B1NYX4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glutathione transferase omega-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003148">
        <property type="protein sequence ID" value="KHJ31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYX4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYX4"/>
    <dbReference type="HOGENOM" id="CLU_003572_1_0_1"/>
    <dbReference type="OMA" id="CVEYYRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="329"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="1">
        <location>
            <begin position="624"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1201" mass="136932" checksum="CA947498A7ED56D5" modified="2015-03-04" version="1">MDNYAPAFVAHNIPLILVSGLNSDFKESSIQQTDTHELNVGPEEAATLSRLLQDVDASNLAWNSQAFSANKRFRVKMVGREYTLPPRTANPFPAQALGTITKSILHSTLSPLSQESSLFPDGLIDSKWIDKHQEFVPCALVSFYKFSSDPKLYQHHDELLKIAIRRERNLLNLSGYKSYLVVALISDNATVISPEIEERLSRIRKETGLDTKTSLLFLSSQKSNAELKGSVKNLINKIYPPCMEYYRDLSKHCRRKKNKGSFSRPTQYSSSAASQTLSNNGWIFRYDFKLGVFAEFRQEMDSALRSYEAAYETLLGTDIFESMTLFSSRWVEARNLADIIALRIVRCLLWNQNYGAAVRRWTLHKEQIKDLIDRNGEGPAVHDWNSWKARWATIMAETISRVSIPEFSGLAKYVLPEKNFMIRGDVKPWEYLHHPGYWFRIASNYLIASQNRASQITEETSSLLDPSESLCRIENSSILNTNKSFDISKKNPPSSQQSVEYSSLILEFLRRAILEFRQRNQFHIVQELQLLSANELVRKESWDEAFKILSNIWKNMPYRNECWWNIVEEILWALRKAAFYVGDAGSILAVDWELMNKEFTYNPCLPYNLSKSLEGMDLKYRPSIVLHNTELHSFLSVTYIFDSPKIKVGDMCLSQFVVSSNAISSAAPILVSKVEICFEGKIGSIILEHHNSEIMPLGKDGLLSIRRVSLDDPLKTGITNSTVSTSLLFESGSTSVFEFNSYLKEAGEVRAATARFFISLELFDLEYVHKIPRKTTPGLWWGEKSARKRPVHISASSITVLPKPPKLKLQFKIMDHKYCINEKLDLQLVIINDEDNDVFVALDAQFLEDQVPKVLLEIESKLENNSDNIETKSDKLNLKGIYIGKIISGESATVNVVVHPFELTGKFELFLKADYRLANEIETSMLKTASIELQIIVPFEASYDFSPRIHPDPWPSLFSHMEGIDETDSQELIAQGIPQKWCLTTHCTSLLSSDIIIEDISTEINLINGNIKCLTTKWKDFPQSGLNLPPGTLHEAKFDITTQNIDIDDRSTTTIDKSLLVLWRRNKDNSPTIQTKLNIPRLHVSGSEPRVISEVSYDSTNPLIAHFNIMIENPSHHFLSFGLFMESSESFAFSGIKQGILQLLPLSRKRIQFQILPYVRGKWLGPIQCVIRDRYFQKVLRVIPSDGMMIDKEGIMIWIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZE9</accession>
    <name>A0A0B1NZE9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005378">
        <property type="protein sequence ID" value="KHJ30061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZE9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZE9"/>
    <dbReference type="HOGENOM" id="CLU_036943_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20304" checksum="99429E0C770AD847" modified="2015-03-04" version="1">MEKVKGLLDITNPYLQEIEKDYPGVGTDFMALLAEGASRVMLGQRVYSKMYNGPKSNSNYSMNTWAAKAAGTATGETISLKKQVLKGTPPRGQNKEDRRIIIRLDSNHEARKSDSFQLRQTIQNLVPDKTLVTDVWKVPSGVAILAPTPAKAATLMQYKKDIENRFGNAVVERQETWTTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX0</accession>
    <name>A0A0B1NZX0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004808">
        <property type="protein sequence ID" value="KHJ30201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX0"/>
    <dbReference type="HOGENOM" id="CLU_331270_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="821"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="865" mass="97872" checksum="D1227718FF9D00CB" modified="2015-03-04" version="1">MATDNLPKFEQAGRFLGEGYSGARWLSRLDYDFKTAGHKITSPEIFFFAIDILFEGEAASWLDSNPVLREIVDNRDSATDKQVADFKAQLIERFPAKLVNHTEGNLQNDIKTFAQRESEPLTAYYQRAVHLLRRSHGRDTPRNASAGRPLVPIEQSVLNSIISVFLDGLRDEEVRCEVFSRATLSCGSLWRCHQIIDEVKQGLDATREARERAAERKEVAQIRAMCAAHYGKSLTSVLADFSSGKLTSPKARQGYSNEFSSDYKNQKPQNQPQPHSGTMNIHENKQMITNSSAPGKVFNNRLNEYPPKNLSRNAFINGSAEYRPSDGPLCFGCGMLGHIKPKCQNLQLQNWEQNHLRYLIYEQKPPQRDSNLSYYFHRDNSNGAQIRPRRPLNPLNDLHSNVNEYQVPNCQYYGHFQSNVQRNDPQQSYQPRFQNTNSNNPKYNQQPENPIPQEQERDNPQVSWSVPQNNQFEDQPYSDCTLSQFAGINIPDERHEKISSNACELDAHFESYSSGPSKKRPRIDIEEILNDNISKVSNTMNEDPLLHCPTKSLKKGRRALKHLREIVGREGCGPINYIDLAKRISIPINLLELWQVSPDAAKGFRRLSTRVNKKKSKRTPTEFFSTSAYNNLVKSSENCRPNLVETKAFRVPVVARAEANGKILKVALPKHVSQADQGSEMNIISQGLVNALKLERLSLGQKGFSGLTMNTADGSATELSHFVSLHIGVCGIWRRIDAFVRPVLKKNGELDLHLLLGIPWLHDVNASIFIRDSRIALGDPQRNERIAVIQGPTFVPSSNHRLVLYPRSNHNAEINKQEIREQAETQNSADSESDTTDALSDSDDSDDSDFEDELPRVMKSPLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P004</accession>
    <name>A0A0B1P004_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003865">
        <property type="protein sequence ID" value="KHJ30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P004"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="307" mass="33635" checksum="19CB800235017229" modified="2015-03-04" version="1">MAPPLVSKRALLPDPPDAGNRVSKPKATPGKATRKTITNAHLLPPTNDARRKEIAIEKVLSEMHGSPDKILDTDDSMEVNIDDELAEDSNLDPFTEEFPSISGTTQTTCPLTPGRVQNHDNKNNQNAANLMDSIKGLLDLTNDYLRNLESQHPGVGAEFLALLVDGAFRAMRGERVYCNTTNVNQTHKQGELNTWAEKAKAHNLGTKVFNLKRQTVKASFPQGQSREDRRVMIRLDSGHEARKTGAYELRQSIQNLVSDKSLVSDVQMVPSGVAVLAPTPAKAAAILQSKSPIENKFGNAIVERQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P023</accession>
    <name>A0A0B1P023_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mitochondrial inner membrane protein 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004662">
        <property type="protein sequence ID" value="KHJ30246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P023"/>
    <dbReference type="STRING" id="52586.A0A0B1P023"/>
    <dbReference type="HOGENOM" id="CLU_045137_3_1_1"/>
    <dbReference type="OMA" id="AWPTLLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="29916" checksum="995A415F13A5B1D5" modified="2015-03-04" version="1">MEDDIDMTKSIRSELMTIKDTFSMKEVPRDSLYIGAAGILPYAATSCSTIYIAWDINYAEENGVGYLLSPESAHQLLNIITPIQIGYGAIIISFLGAVHWGLEYAGFGGRHSYRRLKYGVIAPIIAWPTLLMPVETALISQFLAFNYMYFVDARATAEGWFPPWYSIYRFVLTFFVGASIVVSLISRGQIERPEQQQLKTLKEQANAGREAQFVNLESEEIMRREEQEMEDEEGESNGEDEESEINKETEEIDSNEEEENKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P041</accession>
    <name>A0A0B1P041_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002414">
        <property type="protein sequence ID" value="KHJ32002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P041"/>
    <dbReference type="HOGENOM" id="CLU_022625_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="550"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="734" mass="81275" checksum="3212AE9EB222C93D" modified="2015-03-04" version="1">MVCTSFYSCIESVATSFKDGEDKDMARMLQDNLKSTIAQFAASDADAKTYSPRLITSTTTHTERVKPREVNKSAPVAVPCMFSTTNSGSKVQNSIDPKLPPKPIANESSWSTVVRNGFKKTKTATILASQQKTPTQPRSSGHQLDHRPVNNKMPFPTQQATRPQDKRLFIRLTNGHDWRKLSPAGIREIIVNKLAISPSAIGSTKPVRSGFALGPCTNEAREALLNAAIRLSPFGAKLESATNWTSVLIPTVPKSLHTLNGHVEVIKVLLSQEIERVTKMRPSFLKLYGRNVLEAPHRTWMAFFAKAPRSGFRVFDESGVMRTFKKQQSPEFGKRCNGHHPSKNCSRAPSCGNCGSTMHSEDLCMAQTRCKNCGGPHRSDSKKCLARPTRFGLPSKEQLKTYHQAGEREYQTILRANAAEKMATTAEREGGNITSSQPSEITDTSPIETTVVDAMRFMSINVGRGGATHDIALIRACELKIDVFLIQEPWWSSCTKSNPNFDCHIPFGREEVRPRAATYTRKDSNRIEATQKPTTTLTGDYCWVLVNDIMFLNVYKAPLNPSAVQLLLNWVPPSKAIAIGDFNSAHWVWQPSARCTYGQGDEIEKWAELHNMSCLTIVEPTHRAGNTLDLAWSNISGICAWVDREECVTSDHLPIFGSVISNSIVPHTFEGPLTVTKDKILQFAKVVAQWMTPVCEPISIVELDRYAKSICVVLTDALKAVGSRKRRGKGKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H4</accession>
    <name>A0A0B1P0H4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002617">
        <property type="protein sequence ID" value="KHJ31748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0H4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0H4"/>
    <dbReference type="HOGENOM" id="CLU_089419_1_1_1"/>
    <dbReference type="OMA" id="NAGKEMT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="23262" checksum="24E27F409EDAEBEF" modified="2015-03-04" version="1">MRHPILQTRISYNRVWIETCYFCSQPCYPSKGITFVRNDARVFRFCRSKCHKNFKMKRNPRKLKWTKAFRKNAGKEMIVDTSLTFAARRNIPVRYNRTLIAKTLDAMKRINEIRQRRERVFYKKRMAGNRLREKELNKKLVETQSHLLPRMSGTMKKKLEEEAQNQQLNRIDEENVMMIDSRAQKNRQYQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I6</accession>
    <name>A0A0B1P0I6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative cytochrome p450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004277">
        <property type="protein sequence ID" value="KHJ30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0I6"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="VPEHYEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="524" mass="60513" checksum="5180D3F2959577C2" modified="2015-03-04" version="1">MQLPQTLVTAIWACVAYLVYVVVTKYFRSRRIARLARELGCEKPRMMKNKFPLGIDLALRAIYADKHQIYPVDSVKRLYEMDGPTYEMNLLGMSIISTSDEENIKAMLAVQFKDFDLGDCRRGSFWPLLGDGIFTQDGPAWEHSRALLRPQFAREQISNLKLEETHVQNMMRALETLTPINSEGWIEDVDIQVLFFRLTLDSATEFLFGKSVDSQVLLLRECKDEFSQNLGSFASAFDKAQLALSKRAHFGDLYWTVSPKGFKEACRKCHEFIDHFVYEALAKEPNEKINETERNYVFLEALIEETRDPLALRSQLLNVLLAGRDTTASLLSWLFFLLSQDPVRYKKLRDIVIKEFGTYDNPRNITFASMKACQYLQYCNSESLRLYPPVPMNGRVAKKDTTLPRGGGKDRKSKIFIPKGQLIEYSVHVMHRRKDIWGEDAEEFNPERWIGRKVGWEFLPFNGGPRICVGQQFALTEASYVTIRLLQRFDSMHSNDMDPFVRHNMTLTNCNGRGVRVRAHTVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0K4</accession>
    <name>A0A0B1P0K4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004452">
        <property type="protein sequence ID" value="KHJ30334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0K4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0K4"/>
    <dbReference type="HOGENOM" id="CLU_012062_15_0_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="206"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="32801" checksum="FB419220A165B5E5" modified="2015-03-04" version="1">MSLFLSTIKPTQFGMFQLRRAVLRAVASTPPSILNTRSVNKPSHLISLVNSSVFSSAKFTKRYNGDYSREGRISLNDNHDYLETPEESTRPDFKNSRDSSFTRDRPFSPPADLSPNPSIYVGNLVFHVTEDDLKKEFSSFGPIKNAIIAVDARGLSKGFGYVEFENTDQARSAIEAKNQMVFEGRRLIVNYQAKTRRSTRENPPSKTLFVGNIAFEMTDAELHKLFREVRNCFDIRVAVDRRTGQPRGFAHAEFLSVEDAIAAKEKLTDREIHGRKLRLDFSAGPSRTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0N6</accession>
    <name>A0A0B1P0N6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002237">
        <property type="protein sequence ID" value="KHJ32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0N6"/>
    <dbReference type="HOGENOM" id="CLU_2098638_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059286" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12702" checksum="A471592253D56D99" modified="2015-03-04" version="1">MRVVSGSTFIFFFLSSLSSIRGTPLRGAGTSSITSTSDISNSRTESLKLVPKSVEHGNMRPKIMVQPPRDFRLLSVYHSTEKTARDNIPAPGTLDFRYLTSGAKGAARHMDTPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q0</accession>
    <name>A0A0B1P0Q0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01003534">
        <property type="protein sequence ID" value="KHJ30850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Q0"/>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="423" mass="46970" checksum="459F2CC8C27E7247" modified="2015-03-04" version="1">MAYRPVTQSIQNIFPRNNEKIRKQAPLWLKCASQLRLFAASVHPVTQDSTSSRGPTAMVFMNMGGPSTTSEVGDFLSRLFADADLIPLGPFQNYLGPLISSRRTPKIVKQYSEIGGGSPIRKWSEFQAEGMCNILDKISPETAPHRPYVAFRYANPLTEEMYNKLLDDGFGRGKGGRAVAFTQYPQYSCSTTGSSLNELWKWRQRLEGNKSPLSSKNGADGTINWSVIDRWPVHPGLIDAISLNIEEKLQEYPPNERCKVILLFSAHSLPMSVVNRGDPYPAEVAATVSAVMQRLGHSHPYRLVWQSQVGPKAWLGAQTSDTVTNYIAKGNKHLVLIPVAFTSDHIETLYELDKEVIGESGHQDTVKRSASLNGHPVFIQALADIAKDHLDSGKICSKQMGLRCPACKSERCAETKKFFSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0R8</accession>
    <name>A0A0B1P0R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative syntaxin 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002574">
        <property type="protein sequence ID" value="KHJ31798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0R8"/>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="35911" checksum="B9FE742EC2CD61F6" modified="2015-03-04" version="1">MTVSSIQDRTNEFKSVLSQVQKRQATSKLGGQKQPLLSDSQKAAANANSSGDGKFRRSEFARRAAEIGRGIAVTMGKLEKLAQLAKRKTLFDDRPVEINELTSIIKQDLSSLNQQISFLQTLSRSQHPKTDQEGEHNKNVVFLLQGKLTDVSANFKDVLEVRTKNIQASRARTENFVSSVSAHVTSPITQSNSPLYSAPNRGSPALEQDLLSLNPVGDQQLLMMEEAQPTNTYIQQRGEAIEAIERTISELGGIFSQLASMVSEQNEMIQRIDANTEDVVDNVQGAQRELLKYWSRVSGNRWLVAKMMSVLMIFFLIWVLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V9</accession>
    <name>A0A0B1P0V9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004198">
        <property type="protein sequence ID" value="KHJ30459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0V9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0V9"/>
    <dbReference type="HOGENOM" id="CLU_411144_0_0_1"/>
    <dbReference type="OMA" id="MDNIAKI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="668" mass="76044" checksum="BE867A6B2EFEE8DE" modified="2015-03-04" version="1">MTAAVSMMGDLVRSVAAGQNLINNLQPEPPKVQFYNIRLGLGTSLNTSSSFPSVIATDTAKTKFFATFEEVKSVLTKPRRSYQDIPMSFLGARGSSQKRTDGSETREVAVQTTPPSNGFGLKSVDLHGGSEPLCISNIVIKASNYQSPREEIFIPIGDLGYLCGRKWSWGSVLEGNKQRCIWLDGQSDKSGYKELLHLDIERMAKIFKVDKNDELKRTDLSTACTYIGNKIQNDGLEDSIDEDTDLQQAISDLYNENQLEDQPQPDEIVVGEMRTEDLFAKKQVAIDQQDISEMIDGQEITTENLFSAEKILEAEEEAANEEFQMKKEALEEMLEDAEIQAEDNLLARQALEEERLLEDEIFAETVLIQQSENLSPEEMLGMELNLAQSKLEAEEQFAEKSLEEEKLLVEDELVAEENLAQETLIDEERIAEEELIAEEALAEERLAESFNGETSNEERLEAETELLKAEIAAEEDLLAREKFAEETLENNMLLAEQELAEDEMLAEQELVEDEILAEELEEEKMMLREAISNQNKDGQDFTGPIYSEQQSEESLNDWLEEQDISNEEFIDADFFPQVMTKEEYNYIPDFSEPISDEETYYDDIYQESSQDWLDEQELMREKADWEQAFDEIDVPIFTNSDETEEKDQTNAEVVSGISELKKRQTFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P165</accession>
    <name>A0A0B1P165_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nuclear localization protein npl6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002436">
        <property type="protein sequence ID" value="KHJ31973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P165"/>
    <dbReference type="STRING" id="52586.A0A0B1P165"/>
    <dbReference type="HOGENOM" id="CLU_022149_0_0_1"/>
    <dbReference type="OMA" id="SANWQFE"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="515" mass="57274" checksum="C7BD2DF42D61C33C" modified="2015-03-04" version="1">MGKRPGRAAALNAAAALKNTPRVIDDGDDEEMQDVSSSNAVTPMPQEENVEEAEDIKTPAPESEPASAQTTPVPEPVVRKKKLGRPLKYRPSDSDKINGENSAQEPGTAGKGRGRGRGGFGRGGGRWARRGGPSHVTQQPVDKEGNMMDVINDEVELPEDSEGEKKVDKFGHLKDGREYRCRTFTVLGRGQRLYMLSTEPARCVGFRDSYLFFTKHKRLYKIIIDEDEKRDLIDRELIPHSYKGRAIGIVTARSVFREFGAQIIVGGRRIIDDYEVARAKVDGIQEGELADPSDVVKEGEEYNKNQYVAWHGASSVYHSGAPTVPFPTGKITDGKKKKITINDVNWMSEHAREASRFNSTLGNLRRQNLSGIYDTHTNLVMFPKIIQPTRARWLQVNDVDSDQQSCKHCTEKVGSSSSIFKPLKPICSKNLLVIDTIYESAPASFTSNLNYDDNEFDIGFSGLSSISEDIKAELPPECLRALEKTLKIESQWKSRWELKSENGSAYSPIINKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M5</accession>
    <name>A0A0B1P1M5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002297">
        <property type="protein sequence ID" value="KHJ32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1M5"/>
    <dbReference type="HOGENOM" id="CLU_033732_4_1_1"/>
    <dbReference type="OMA" id="LCYYWDT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="88"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="35498" checksum="E97F53F3A9B09AB9" modified="2015-03-04" version="1">MMIKLTLRKPVLRLFNHQLRLYTHSSNQNPSQEKGKGSYVSLSYHWDTKPPSPVQLKKAAEFFQGSTSKFLWSRENFKDMPFGHDFGERPEVCFLGRSNVGKSSLLNTLLCQRIAFTSSKPGRTKLMSAFAVDSEKAIDKNKNKLIFLDVPGYGKGGRADIGYEVIKYLNSRRQLKRVFLLIDVEHGMKKSDKHMLDLCKQINVPFQVLLSKVDKVISSVITQETSKSGRLGEVIDQLKEAIGSESIANGLAFGEIIAFSSTKWMFGRRLGINEVRHAVLRAAGFEYQETQHRSNPGVIITYDQLFPSTCQDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P8</accession>
    <name>A0A0B1P1P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002276">
        <property type="protein sequence ID" value="KHJ32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P8"/>
    <dbReference type="HOGENOM" id="CLU_1251485_0_0_1"/>
    <dbReference type="OMA" id="THIRCAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="24920" checksum="947BCBFA459B79FE" modified="2015-03-04" version="1">MRNDINKCMGKRAVARVHLSPRKNMVLTCHEMSPDQMLAKKEAWQHIFNEFSLTNIQKVDNWPKLVAHGVPAAIPIEKFENEALAYNKVLIKGQPRWLTGTPKKQHASVVFSVATEDEKKDLKKNGITIGGCLLKVVNYKSMTSKTQCRRCLKYGHLELTCTKPAICGYCADTHHTSKHSCATCNSSNSCEHTHIRCANCKSDSHNAFERQKCELYKAISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1T7</accession>
    <name>A0A0B1P1T7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002243">
        <property type="protein sequence ID" value="KHJ32208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1T7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1T7"/>
    <dbReference type="HOGENOM" id="CLU_014084_0_0_1"/>
    <dbReference type="OMA" id="NTTHARN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="770" mass="86456" checksum="F949BDFA9826178A" modified="2015-03-04" version="1">MGLQSVFQWWSQPTSPITLDDSVISGHASDTLDPFDSTPRAVALEFRRSDVKPQIARKYSSLLTKAINGYNIETEETEPTNLIIENSGIRRPQSFGTNSPELTSDGGTTSSSLSHTPNSCLDQHPQHNAYSFTEKHIIGPVMINASPMSYNNETTKRTQTESSSVMMDILGPSESNVLPCLELQQSTPPRKRSILFICNDGNGIISGSRSRSKSHPHFQSGPIFTTDELEIGDCHPTPPQPRKSIIKFACSGPLSVKVPGRSDASSAPLNSSGHNSTPSSLGRNSLCTNKIIEHKIRRQLREQTSRSIPMSINPGLSQATDFFEFASEEVEVENWLRQDLSPLTSKLTIKDTFKKENEIRRLASEVEQEELDEVEANRDDSEGDDEEDEEDDDDDDEEEGESNDFEFEFDSSDVGNQTDNEGGFTDSDESDFEKDNDFWTPRRDECKGSSRQFLGTDFSSLGASAHYRSGSNSSTDIPPNERNFIRGKRHRRKLKIMRPGTPDLPDSTDFVCGTLDEDRPLEEAYLSCLEARKQARHKLTPQDIDPSFPTSDTDEDQKDNKQDVSNFSEGQRKNHNGKSDLKGGRLSRNISRNRGSISCYSPKKLHSPPPPKHRFRSPSRKTFNKSPKRSIPTTPSHERRLTMPISPTKAALIFPLGTRSRVTHTKSLPRTPNLFGLQYCEFKSRLFDDSDTVEYNHKDHHVRGAIDIVKGLERKRQRRKEKLYMKPNNRKTKANTDRKPQPGLGAERMREVGLTMAGRTGGQRAYMLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P292</accession>
    <name>A0A0B1P292_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002878">
        <property type="protein sequence ID" value="KHJ31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P292"/>
    <dbReference type="STRING" id="52586.A0A0B1P292"/>
    <dbReference type="HOGENOM" id="CLU_006783_1_0_1"/>
    <dbReference type="OMA" id="WKYITDS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="380"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="886" mass="102021" checksum="EF1B80E641A8DF37" modified="2015-03-04" version="1">MHALIAATVMPVVSEDFNQSRPLFNGKKFLVYQRIPQKSEIVEMIKANGGSIAKIEHDADIIITDHALGHPRQNSIDWKYIRDSVQNGKLEDIEKYRALPNGTSLHNIEHKYPKKIKRTPFTSEDDRVLWEFCTKDNVIKKGSKGNTIFEKLEKINGRHTSQAWRARWTKYVSSNPPRGISEMDRENHIWPCENIEHNANSTRSKNPNLVNEINPISYENQQNEVVDSLISQITCQDRTDDPKQNVFTDSEINQLFDAYSEILSAPEEKKSEAWTSWAKLNPTHKAEEWKTQFYEYVMPRQEALIAKYQRMRKRSYATERYQFPSVMQPSTKNVLKETEIEVRSPQSIKSLEQLAGNPNELSEDYVFFSEVQVLLSDHMLHNEDFFKQSLQYLADELGLEVNFNPQIGEREIPLMKLWKTVQSLEFGGSKEMKVDNDWQRLAKSLGFIDHITMVAQELKDCYNEILADLEHLRHEFLMEMPFSSMQKKVLIEKLPQFISHQSSDDYTDSEIMDNLPRETQFLCNDSIDLDTPRTPEEPQKLGKKRSLDLVSSHKKFIPNKRQRISDGKNKVLEIPSTPESIINFNQNSYLNQENSLELINLSQNFNEIEVLSPSPSNFRLDTRKSISNKSISPPVMEPEKQSNCYAGIDQIFDSRSNSKSLDTTEIDQKFRSHGEKRKKKPSAANSVQIVRDSIENSTEKSFSLHDGISSYTIKKKLSALSLSENESRENSPCPEKGDKRIVDQNISSLTLQEEGELQAHKEEKSKLDEFVENQIVLGFSIKTIIRALEATSMAIGPTSHIDTVLKTIEKTDCIPEDLPGVWTTSDDELLKQAILSLSSSSSYTDSKIMKPLYRKHGEINVQLRQDYWRFMEILNQEQMITTDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G4</accession>
    <name>A0A0B1P2G4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002816">
        <property type="protein sequence ID" value="KHJ31535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G4"/>
    <dbReference type="HOGENOM" id="CLU_053603_1_0_1"/>
    <dbReference type="OMA" id="ENCDYQN"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="278" mass="32256" checksum="A5EB6A22A52D6797" modified="2015-03-04" version="1">MSERKVLTKYYPPDFDPSKIVRTRGPKQAGPKVQTVRLMAPFPMKCTTCGEYIYKGRKFNARKETTEEKYYSISIYRFYIRCTRCSGEITFKTDPKNMDYECERGAKRNTEPWRMNGGGKQESDEERLDRLEREEEEKNAMQELESKTLDTKREIAVADALDEIRTRNARNERVGKDGREALVVQESIDEARRRQDQEDEEAARQAFMRYHKGLEEVIVDEIVEGDQTELASSSVTDIDEKILMPPPPPPIRPTFKRVVKKKKDHAALLGIKKKAPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2K6</accession>
    <name>A0A0B1P2K6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative stromal membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003180">
        <property type="protein sequence ID" value="KHJ31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2K6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2K6"/>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="OMA" id="MVCKQIW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="579" mass="62235" checksum="C1B435CA84ACF72F" modified="2015-03-04" version="1">MSRRTPNPAAERAARNAQTIKSLLKLEGNKTCADCKRNKHPRWASWNIGVFICIRCSGIHRGMGTHISRVKSVDLDAWTDEQLQSILKWGNLRANKYWEAKLATGHIPSESKMENFIRTKYESKRWVLEEDIPDPSTLGVDGDDDVPLSLVKQKQDIERLSSQRTSLNQSFALPQSKRAPQPDLLESNNSIASREGSANFLAYKLPSKSEAAPPKQTKPMDSLLGLDFFGTGTAPPARLTNSIPISGAQSRPDLKQSILSLYASTSRPQQQTVQSPQNIFGPMQSPLKSPADNASLGSLSDAFSSLKFPTQKSSSAIGTTQIQPESPASNKSSNALNTKTITSQTISEKASNDYSKQISETKNMQSPVQSSRGLSISNGIDTFNKAIGPLHNEATDSSSRFGDMFNFATPISTSQDMGPAPISSAISPASQKNSVFNLTTVNSPLSKSKISPVSNNLFSNSDAWGSNDAWASATDSSSKTKIPASPARFEEPRWGSSSGNMATNLGTNSFVGSEVNNKIYGSYNTPPVVSVDEEFGGWGSATTAPVTQPVATTVTTSVASHKPAAGFAGNDDLFSNVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W8</accession>
    <name>A0A0B1P2W8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002683">
        <property type="protein sequence ID" value="KHJ31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W8"/>
    <dbReference type="HOGENOM" id="CLU_2387803_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="94" mass="10237" checksum="DF1E8F6D9D90A7F6" modified="2015-03-04" version="1">MHTENDCKALTKCKNCGGPHRSDSHKCLARPTRSGGPTKEQLKTFRTVGEREYQAVARAKAAEQKALASEDNILIWVGWCSGMSSGPVFQVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Y8</accession>
    <name>A0A0B1P2Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003313">
        <property type="protein sequence ID" value="KHJ31039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Y8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Y8"/>
    <dbReference type="HOGENOM" id="CLU_463216_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="589" mass="67568" checksum="107C13017F79E5C5" modified="2015-03-04" version="1">MNHSSKKNMYTRQDNLPSRNLHINPKENWNSLPQVHRTRLGEYDSYGHRSYLSREQGHESNLKIESHLMNINPAHILEVLRSRMAAILSKIGREVTSLNSYNSEEFFHEFQNLFHDFKRAQVSLLEEFEHISEAKASYYEQFTLAKSKLLQIYEERDRLSKEMEVIQQILDETRDKLKNSYHQHQKFKSQKLSCKDKNIYRGNSTYLMDKADGNSFSPNISDLEMSASFTKSGSSSSLKRPFEKLNPGPQTTHSGSTLDISSDSSLSFGSYFMGILERQNFYQEHALPKNSSIRNVSEIKKKNINQNINSYNPTYTSEDDPAPEFKVGFDKVLNMIEKWCKTNANQPNECNDAKVALQNPSLWSYMMDCVDCGDSDVSESRVKDLISSASTRYRFVMRMATTYIFKDLLSLKNFYGFNEEANKMLNDFESMMEERGMKATIRQGIIDRRDTVIKNIIEDTGYDLLRSMRLNQHSNSLRGILGSFLNEDCDFASAGRDLGAIVALSFDLCARIHSSALTFQILFPNLTSTKFNASTMIVRDKILIKPLALHHIAMTRLKLVISPMVTLRDDRGTTIKAKSLQLATVLTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P389</accession>
    <name>A0A0B1P389_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rnase iii domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003209">
        <property type="protein sequence ID" value="KHJ31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P389"/>
    <dbReference type="STRING" id="52586.A0A0B1P389"/>
    <dbReference type="HOGENOM" id="CLU_057354_1_0_1"/>
    <dbReference type="OMA" id="AHTMYAV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="41"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="195" mass="21825" checksum="C0AEAC456149CD08" modified="2015-03-04" version="1">MPVRVRPLNPNKKWECNSDPKRLDRFYVNFLGPGGDNLLSDEVKWLAITHKSFEQGARGFNDRLAFLGRRILNLQADLLLFSSPSIRQLENPIEIESETRVPFQHPALIGLTNLIDSPLTNILSKEKLASFATNIGMRPIIRWYPRMVQDLDSSGIETVLATSLYAIVGALALEKGGEVSSDIAKNNILKPMGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W5</accession>
    <name>A0A0B1P3W5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002991">
        <property type="protein sequence ID" value="KHJ31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W5"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="128" mass="13996" checksum="785D995AF09A84C2" modified="2015-03-04" version="1">MGTTHVKIVREHRHAVTVAQPINHTVEVCMAATKCRNFGGPHGADSRRCLAHPTRSGAPSKEQMKAYRQAGEREYQAVQRARAIEEEADNIECIEIDRSSSHMTESSGSTNKIEATPVDSSTGVAPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P428</accession>
    <name>A0A0B1P428_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001429">
        <property type="protein sequence ID" value="KHJ33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P428"/>
    <dbReference type="STRING" id="52586.A0A0B1P428"/>
    <dbReference type="HOGENOM" id="CLU_018299_2_2_1"/>
    <dbReference type="OMA" id="GEHENNK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="227"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="415"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="515" mass="58923" checksum="ADCD8E26D37367E1" modified="2015-03-04" version="1">MAKAETLAQKISNLAYPTPRDFDPEDEYPVSEDEASESEEEESGDDLAGTEHYVQSGKSKLRKPEQINLGPKYSGSQISRRALFADHQNYSLDVLKNGPNRSSPENFSNSGEEDCNSSLEDESIDSEEVQSDLEEQIPSKVKNTSKYSKEVTSLEGENKLPKNHETDHLDNNYSDISDSSDSDHDRCDSNFSNRNDKEIIKRSEIQRFMEEDQKAILSTLSQAAKVDAEKGRAIKSQQMRFDSLLNTRMELQKALIAVNSLTTFQDDNSIFSKDKPYEAAEEAALKLWNRLFEFRNNLSKPTTTHERARKIITSDQKLSSAMWEKMKNLESASIDDRQKIIEKWSIKTRGSMTHPLTEKLNPTITQQNIISFLNDHLENSEQLIRRTKIPRSCAPIQRDLKLVEDPNIYDDGNFYQMLLKELVEQRRSELSSMPVTSTTDNQIKPWTAIKEPKVRKVVDKRASKGRKMRFTVHEKLQNFAAPEDRSSWEQLAVNRLFASLLGQKVVIDECSESDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A2</accession>
    <name>A0A0B1P4A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative gpi ethanolamine phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002280">
        <property type="protein sequence ID" value="KHJ32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4A2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4A2"/>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1053" mass="118484" checksum="7905372620FE2515" modified="2015-03-04" version="1">MSSQNLQTIENTRLDPLGKINGLNTSENRKNVIHKLNETKKENFIREWHWGLAFFIWLLLIHIIGVYFFTKGFLLTRLVLKEKSSCEAQVNISIEPFKGKSTYDAGCWHPKSFDKAVIIVIDALRYDFTIPYTGNHKKFFHNELPILYNTTIMEPHSSFLLPFIADPPTTTLQRLKGLTTGTLPTLIDLGSSFSGTAIEEDNLLIQLKDAGKRIVHLGDDTWTKLFPKYFEENISKAYDSFNVWDLHTVDNGVTENLKPLLRRDKKETWDIIIAHYLGVDHAGHRYGPDHPAMASKLQQMNNVLIDIVSTIDKDTLLVVMGDHGMDLKGDHGGESDDEVQSALWMFSRKEIFGRTDPKHFIPPLSAKERFVNQIDIVPTLALLLGIPIPFNNLGKPIQEAFVGKKGNDWKNLASVARITAAGTKKYKSTYHATRGFTKPADTDSVENIWVSGEKIPINSGKKSAKEAFLTFSAFSDETLKMCRNLWAQYDLPSMIFGIGILTLSIILLISYAYEILQEEPQTNDSEVDQVQFQLELQNFSKGIKTNHSDKSPSKRIFGNILNYSLLGVIFSPIFWNFTRTFSVIDIGLSTFATSGLLGVLYQEFFRKVAFDKIFTKNYWSWLAFTFTISQALGFASNSYTIWEDSILLFFLSTFGISAMISSSRIRKSSDRALGIYHSLIFTILSWVASFSKLCREEQMPYCQTTYYISSTSSTSALWQVVIPFIVALILPSIIKSFYTGSRSYEGFAPIWIGWVFRIGLTLNAIFWTIDAADDGQWFPSITSTFLKKTRVVIAQTILSSVIGAGSTAFVYAPPCVSVTTTMDSKSGHQGSNSPNPKITILGFANVHGTRYFLLLLNVILGIFLLQKPMGAGALSLMAWQILALSEILDLNSLASSPIGPIMLALLGSFHFFKTGHQATLSSIQWESAFIPFHSIYYPYSAILVALNTFGAQVFAVAAVPLLVLWKQKPRKKNIFRSVLRALAWHICYYAIMAASTSLWAAWLRRHLMLYRIFSPKYMTAVSVLFMVDIFGILVVLIGFRSNISSISEIFGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D5</accession>
    <name>A0A0B1P4D5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001360">
        <property type="protein sequence ID" value="KHJ33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4D5"/>
    <dbReference type="HOGENOM" id="CLU_018409_0_0_1"/>
    <dbReference type="OMA" id="RCANVNV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="546" mass="59954" checksum="5D2354BDAC24F87E" modified="2015-03-04" version="1">MHERRFATQEQYISTKDGITSENISAVGFFGPLTPTLPIEDDDPPSTRKHSIEIDSTLEITIPPPKKQRFTNNCDDIQAIEQNSCNNPQSKLSDAGPKQSTDESQVNVNSNEQAYPSPEQISTPLAISIKSGHDKGTQVEKVHDLTPETVYLELTENPLIKGVILAHCAFHPRDSNILAAAGSDALARIWSLKSLSSLKSVIQSPGMPIYAPHRNLYDLSVSMATQATALSWAPEGQYLAIASQPSETGLSRVDFWREDASLVASNFGIDSPVVNIQWNPSGTACLIISPQNETTDASITVIYPTLENVLRFTLPSHNLVEQLLQAVWTSNDDFIVCGGNLLQAFLCSAKTNSIIPGRKYEVPEEAGLSQVVYDLHSQLLATASDTGMVYIWGKDDPMYVFTAHQGVITQLTWQSLTTLDPTSNTKERLLASAGEDGAISIWNIVLPNIKCRASMTMRSTAFAIAFSPDGEFLASATSENLFIWKTDSPHIPLGTWTRQYESGWQTPLSSESTLSEVEICSLSWDSEGRRLAYGMNNRLALIDFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4G1</accession>
    <name>A0A0B1P4G1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002605">
        <property type="protein sequence ID" value="KHJ31776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4G1"/>
    <dbReference type="HOGENOM" id="CLU_694818_0_0_1"/>
    <dbReference type="OMA" id="WEIDEIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45206" checksum="0F3DF95A8E6B9F2E" modified="2015-03-04" version="1">MGSQTKEVPVEAHQSVGKVERYHKILRRSYDIINEETKELKIDKDVKLQMAVKTIIDSAGPDGHVPTLLVFGAYPKMTYLDPPAPKISQRATALKIAMEEVRKLKASRYGYTEKIWGGKDHLRSLQLKEKTVQSSSIKVQLLSIKQKNDLIIANELRNKGIIKTPELPFETSTIQELEGLLNRGVFELVPFDLSTMSNTRIYKARIVNEIKGKTTSKPYEKSSFVVQAYSDSGKESFLRQSPTIQRASQRLLMCIAASLCLRNSKEETYETWLRDVTQAYIQSTSRLNRLILARPATEIIQQIKPILLKLKKPIPKGQDLVLRVIKPLYGISEAGTHWFFTYTTHFIEKLQLQTSTFDPCLFISTKSDEFGIVGMQTDDTLYVGNKSFIKKENMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4M1</accession>
    <name>A0A0B1P4M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002535">
        <property type="protein sequence ID" value="KHJ31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4M1"/>
    <dbReference type="HOGENOM" id="CLU_1273087_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="24599" checksum="EC548FE67E010C41" modified="2015-03-04" version="1">MLFTVSSSEERIVEDADGYEVKILPGNDRLVIDTKCDIVGAFIDHGHIFDRDTRYERCSVLRYPGDFSASFEAPGLSCYDPSSGAPQASHQSPQRSASPPGSPKQTLQRSQQQLVSIPHPESSEQHHERSRSRLRQKLRQDSASNYPTESPERHFQQSSKLSPTRSPEREAKFLSDQPVDESRRLSDKLPDWIKVVPPPKPLNIDIFNFKESNKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q6</accession>
    <name>A0A0B1P4Q6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001546">
        <property type="protein sequence ID" value="KHJ33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q6"/>
    <dbReference type="HOGENOM" id="CLU_510174_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="534" mass="60758" checksum="931844055125BA43" modified="2015-03-04" version="1">MGPRTRSQSQASKSRSEGDGSLNTRIDILEQKFEEVIEDIEKSNRLVEDKLKIMASVIKNQVENKIESKMRSEFESMTEILKKTLNDMNSTKNNPASPENSFVSMNFKGSDIPASPGKVSQEQETTQFKLTDNADEPDGVFKSDLGEPSRFPNGDFNLQIPFQLPQACTAQEKRILDDWPEVVLPSQAKLYGATSHKNRVTFAPGTCLSFADSKVLPTLAQIQEQLKTALIPYQFWAMRLVSIMNEDFQQVATWAKRGNPTWLDLVEAIIQVLKKHQTLYSQMTQFARMAPKYEEDKLQFLRRIRNAYYQLPSIHQSSLAVKEAFRDHMQQHLPLVLLHMGNKLSTKSTADAIEEAMRINTMLARELGSKFNSSDTRSSTLIHPTLESTFSSSANEPAFPASVSENHCFLCKQKGHWANNCPTAAQKKSQFTRPSDGQPIVIKGTLYKNQLVKFSDKLKNKYSNFKNRPQTSNKYNSNTRNRNYLASSQIKSDDDVSFIDEHEVNDDNKIDDDDDDDDEMMELYLRMNEELTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R1</accession>
    <name>A0A0B1P4R1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001289">
        <property type="protein sequence ID" value="KHJ33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4R1"/>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="OMA" id="WGIYEEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="34068" checksum="519FB4B81B529938" modified="2015-03-04" version="1">MSHGDQRKSVTGSSIPGLLSGICSAVLLQPADLLKTRLQQSGRSSLFDTFYDVSNSSHTVYQFWRGTTASALRTGIGSAIYFPSLNILRQKIAKSRFNQSSVTKEKGNMNHSSSLPELSNFANLITGAIARSFAGFMLMPMTIIKVRFESNLYTYKSILGAGIDILKTEGCKGFFAGVGATTARDAPYAGIYVLFYEQFKKKLCNLTLQFPITKSSINMNGPKSASVNFASGMIAAGFATALTNPFDAIKTRIQLQPKVYPNVFYAAKKIMREEGPKPFFNGLGLRIARKALSSALAWTLYEEVIRRVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P545</accession>
    <name>A0A0B1P545_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative duf431 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001463">
        <property type="protein sequence ID" value="KHJ33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P545"/>
    <dbReference type="STRING" id="52586.A0A0B1P545"/>
    <dbReference type="HOGENOM" id="CLU_080487_2_0_1"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="107" mass="12082" checksum="5DDD929FA5F6B188" modified="2015-03-04" version="1">MTFKKYIVEHLDHELGPWSELEYLTIAKECHEAGDLFCLSSVPISLVLPDYLENTPGFTADNRSVEIMHATDKEKVCLLDPSAPKQLQPEDGDAYNVFLFGGILVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P596</accession>
    <name>A0A0B1P596_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative folic acid synthesis protein fol1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001198">
        <property type="protein sequence ID" value="KHJ33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P596"/>
    <dbReference type="STRING" id="52586.A0A0B1P596"/>
    <dbReference type="HOGENOM" id="CLU_062068_0_0_1"/>
    <dbReference type="OMA" id="PCLIGVN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="32263" checksum="D0E82C34E50E49A1" modified="2015-03-04" version="1">MSCLESAWKVKYSQYEPHSVIRVLNLQCSLATVRDAWGRHPVSQPALISCTVSLKAPFTLTVLEDAVNDTTVHYGTLSKSILEACNRYSNANREQTIMLSHLIYFIQWWLTGIDLMVESNIDFPTVFLLNKTAIELLTLEVVLPKASLLGSGVKMEGGFRYNESNTAISTYFMTFELSDLRIPTLIGVNPNERLARQIVNVTVQIDYFTSLPEEFFMLEQAITKSVTESSYQTLEALSKQVGDSVDAILRPNLSNVWPTIRVKLSKPTAVTLAEFPMIEMLINTKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5I0</accession>
    <name>A0A0B1P5I0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002259">
        <property type="protein sequence ID" value="KHJ32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5I0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5I0"/>
    <dbReference type="HOGENOM" id="CLU_049909_1_1_1"/>
    <dbReference type="OMA" id="TLITICC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25734" checksum="70E8EEA65F6E940E" modified="2015-03-04" version="1">MGYFPLGITEVWKSLLLTSILFAGPLFERGFIESGWKEWINWRHFKESISTWIGWRNYVVGPVTEEILFRSASIPIILLSRMISTPRLILQPPLIFGLAHLHHFYEFRIMYPHAPESAALMQSLLQLGYTTAFGAYATFIYVRSGSLLSVILVHAFCNWVGIPRFWGKVGEYYIAVNGLVSTRSRSQVVVWTSVYYLILVMGAWGWWKLLWVLTCSSNRLVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L3</accession>
    <name>A0A0B1P5L3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ef hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001127">
        <property type="protein sequence ID" value="KHJ33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L3"/>
    <dbReference type="HOGENOM" id="CLU_009681_1_0_1"/>
    <dbReference type="OMA" id="GCACNCC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF8">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1029" mass="118681" checksum="91AD6C374F98FFD9" modified="2015-03-04" version="1">MPLFVLSPKSAPITIIKPQTTIIVVASFLAILAACKIVKHSLFPECSQSHSGVHRSNAIRRRQRTGTNSTGSDNVVPNLQLDDQDQNEATRFVLVNQNPIDNVSATENSAIHEEYDWSMPQGHERNGQNIVQLLFRVSEDATKRNAYVHRGCACNCCGMVPIRGIRYRCANCADYDLCESCEAQNVHTKTHIFYKIRVPVSGIGPRNMQPVWYIGDPDSVTRQLSRETLIKLSRETGFERPEIEAQWEQWTFMANTDWREDPYGIHLAMDRKTFEQCLVPTIAYKHASPYLIFDRMFSFYDSNKDGLIGFSEFIHGLAFRKKKDKWKKIFEGYDIDGDGYVDRKDFLRIFRSFYVLYRSLHAEMLDGMVEQQLSSADAHRLVNSRQPLSSLFGQDGRFPRAPNSRTGEGKVFQPNGDLEIIDGKGVINESSLDHGNRHEVFRQERLMRNWTGDRSNFRGYWEAILNPPETAEQLRTRLNQIRVTPSQPFGQVSGRESFEPQTAEGETLLIAQRDDYAAHSDSDSDSYEGPWPPTFIEVTDQDAEAVQGPGTRVLDVRRSRRQNVISHAYLRRHPDTMFHSLPESHQNSILQFRTQRDIYRRWQRRHFYTEEEEGETPPADWKDEYDILLQKGIIDESFKNSRPSLPLRSSSSKIHLTRDMNDFDIRSNFSTSSKSVPDRCGGLDISVAEKDAGKEILYQITQQAFNELLDPLFKDKEDVAIEAANLKSMREKYRHLYTTPDFHKWAISYILEEPEANQFNSKSRNPNDAMTHQSENKKESEVSCVHTNLDILSNTAVTIEDDTDMLQSNISQPLELEPVSQTSSYQLPSSSNNPEPISIIRNSNRDQRDLRAVLPTGISREESLSFPIYRDPTMPQFRPDTQQQLSINSQSYISLEDSYFQYRDSTDKERNCYEKEKLQHHRPANPTPESVEQKKITSDSDGGGDQVTKDQEQEDNGEHISKLLLFKLWASNQWIREAERRGGWGKISYKEFERKVKGEMEKDKNKVQYLERNTPRMDYLGSWIEFCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N0</accession>
    <name>A0A0B1P5N0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EV44_g2744</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001350">
        <property type="protein sequence ID" value="KHJ33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5N0"/>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="549"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KHJ33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="753" mass="84967" checksum="EACAC2CC3B8BFF04" modified="2015-03-04" version="1">MLDSDYEVFLKGYSGKNTRSLLRLIILCLVAAAAISSRLFSVIRFESIIHEFDPWFNFRATKYLVQNGFYSFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGVIYHALRALTIPVDIRNICVLLAPVFSGLTAYAAYLFTNEISKTSSAGLLAAIFMGIAPGYISRSVAGSYDNEAIAIFLLIFTFYLWIKALKLGSVFWGALCALFYGYMVSAWGGYVFITNLIPLHVFVLICMGRFSPRVYVSYCTWYTLGTLASMQIPFVGFLPIRSSEHMSALGIFGLLQLIGFVEFIRDSVPSKQFSVLLKGFVILVFLLALACLVLLTVTGVIAPWTGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNILIWLFPAGVYLCFQKLADEHVFVVVYSILASYFSGVMVRLMLTLTPIVCISAALAMSNILSVYLAIDLPSTPLDSTKTMESDTSLSRTAKVGKQNDIRALRIPFVGIFTSFSKILVAGAMTIYLLLFVIHCTWVTSNAYSSPSVVLASRMPDGSQHIIDDYREAYQWLRQNTPENAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPIMRQHEVDYVLVVFGALLGYSGDDINKFLWMVRIAEGIWPDEVKERDFFTSRGEYRVDEAATQTMKDSLMYKLSYYKYEALFAAGQVQDRVRGVKMPNVGPTLNSLEEAFTSENWIIRIYKVKDLDNIGRDHASAISFEKGIKRKNFKKTEPRILRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T0</accession>
    <name>A0A0B1P5T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001083">
        <property type="protein sequence ID" value="KHJ34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5T0"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="13072" checksum="114156C1C8C8F009" modified="2015-03-04" version="1">MVLGVDVAFALSTTLKEITEQLGFPNAPTIICTESFSLYECMVKLGTTKEKRLMIDVMAIRESYERRELSEIRWINGDDNPADAMTKVSPTKSLELLVNTNKLTVRMEGWVERKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Z0</accession>
    <name>A0A0B1P5Z0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001289">
        <property type="protein sequence ID" value="KHJ33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Z0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Z0"/>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="193" mass="22271" checksum="E3661238B0E13595" modified="2015-03-04" version="1">MSSQKETFEFPSYYFFPPFFTLQPNTTTKHAQLQKWTMFILSYARHHRLFKLSLSDSLDSELFNHKKLGKRLSREDATEVIEFMRKQGRAEWINSGSSKGNSSSESAGANSGVFWVWWKNVEEWGEAIADWVDETGQKNMVLTLYELTEGESSLSQEFHGLHSEILQKALAKLVKRGKAQVFGQEDQQGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P644</accession>
    <name>A0A0B1P644_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative atp synthase mitochondrial f1 complex assembly factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P644"/>
    <dbReference type="STRING" id="52586.A0A0B1P644"/>
    <dbReference type="HOGENOM" id="CLU_047893_1_0_1"/>
    <dbReference type="OMA" id="QGWVMGL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="41010" checksum="C3E2176C0D8A6B01" modified="2015-03-04" version="1">MLLNRCKFNMSLYSSSRPQYNTFYHRCKTSTNVPFFLPTNTSPISIGCVRSKATTICQNYDENFRKRRKNNRSNKDQKRFWDKVHVREVDNGLQIYLDNRPLRRSNSKTLTIPSTKPHLATAIASEWDFLESTRNALKPHLTPLTSLVSRALDIVESDIADKTNNINSGAIRDTIVESLLRYLDTDSILCWVPTPYEIPSYENHVSRIEPLRNIQQQSAQPIIDFLEKKLWPGANLNPSLDEYSIIPITQSPETRQIIRNWVYGLNAFNLAALERGTLAGKGILVAARLVAEWGEDFRHLFGNDHEMNKFGIEEAAIAASLESEWQIKMWGLVEDTHDVEREDLRRQFGSVVLLVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P692</accession>
    <name>A0A0B1P692_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tbc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001787">
        <property type="protein sequence ID" value="KHJ32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P692"/>
    <dbReference type="STRING" id="52586.A0A0B1P692"/>
    <dbReference type="HOGENOM" id="CLU_003538_1_0_1"/>
    <dbReference type="OMA" id="IYMSETQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="285"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1121" mass="125270" checksum="3930098201E9157A" modified="2015-03-04" version="1">MFNLSSLVQKAQSLIDPIQALNISDSERNPAKATLFRHQFRLPDSQTPLQEIAAELTISPPASCNPNATQGEKDRDRDRGYHYFGRLHLSEDYLCFSTQQTSFLQTASTSNSSVFTGQTHGAGPGGNGFTLPLCAIRRVERLHSQSYHFALAITTWNGLTKQSSSNVSKTPISLQKMTVQLAGTRQACERFCDGLKKGLKRGVGDVGKMKRVVSECYSEYLLQSDSRNPSESPDAGLGMIYRYPGDPKKLRDRSKMRLWAEYLRENGRNVTSVRQPSFHKLIRVGLPNRLRGEIWELTSGSLFLRLENPSLYADTLAKYHGHESLAIDEIEKDLNRSLPEYAGFQSEEGIGRLRRVLTAYSWINESIGYCQAMNIVVAALLIYMSESQAFYLLSTLCDRLLPGYYSMTMYGTLLDQRVFESLVEKTMPILWQHLIKSDVQLSVVSLPWFLSLYINSMPLVFAFRVLDVFFLEGPKVLFQVGLAILRINGEELLDANDDGAFISVLKSYFSKLDESAHPKSENPKLRAVTRFQELMVVAFKEFSGITQNSINEQRIKHKGAVLNSIESFAKRTSIRNLGPDSKKLSLDELGALYDTFYGVLYEREQKIQITQGEIERQRKAQKSNKSFVVDGPSEKQVIEKGRVGLGPSPTLMDYGTFREFLASITKWAISDSPLTPVKNVMAEKGKNSGNNTRRKENSLSQWDSSNPEPADHEFMQRLFRRWDVDNNSALTLQNVVSGIANIKGKRDIMGSITYFFELYDDDNDGKVDREGILRISEALLFLSRRGLGGTLASSSPRAYTGVDNGNMTSNEAQGNVNERFLSSVSGFIRRCFEYADSDNMKSLAIESNTQTSIDESSFGLADDSDDEENLIEFDPDESTTKNNSSNLRSLTPASEEIAKFPTDRKASIVANVALNPLKPLHITLPTFRMVVLADELLEQFFESSFPASFYISENLTSPGILRPSSSLTTFSNISYLSSSGMSMSGPSSAGIVPPVKGLRGVLDNIVTDGMRVAAEVRRRMDETQKEVDSSTGPRPDDDEDEDDRGYDGSRVNGVYGDSERRSVRSEDRDLLEGAEAEAGSPKVFEAIMGKSTTLKQINSPIRETEYMFGDSESQNTIEFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F5</accession>
    <name>A0A0B1P6F5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carbon catabolite repression protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001224">
        <property type="protein sequence ID" value="KHJ33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F5"/>
    <dbReference type="HOGENOM" id="CLU_018982_2_0_1"/>
    <dbReference type="OMA" id="GMATPFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="635" mass="70565" checksum="A445179F987A30C2" modified="2015-03-04" version="1">MPKLISALTGKNSSPASLFEIRLTKDAVVLYGDRREAPSQLMTGVVVLSLYQTIKVEEVYLRMSGQLKISGLPDKKQNFESENKIHIERQCEIFSHTWPSFVGGHGSESSSKGTIMHSGNYEWPFELIIPGSIAESVQGIRETYIVYNLKAKVARGKLAHDLVTWKPVRIIRTMESADADLSQPMIVENVWPNKIEYSVMVPQKTVIFGTAVEVQMRFTVLLKGLRIGEIRCHILEIVELSSGLPSRSEIEKCRKHERRVAMSTFSMNEENYHEILLDNGQDGHVLIEKIPLPKTLSECLQDCDVHGIRVRHRVKFFITLHNPDGHVSELRATIPITIYFSPSVPLTAEGEIVHKIVDSTTSMDAMRHAPPLYGHHVWDQPYGCTFFSGMTSPMFESGMNTPLFAHSRAGSSDNLSALDGTLSPCSNATNDVTPAALSSRLQNLSFSSRNSSFRRLAGLSGSGSSTPHIYPNTESESNGVSDNLNRYDYFHNATYHSNPMSRRSSGDTEPLSLPSAPQTPYFKEAFEMGDLNRVPSYRTASKKPARNILNDSLPDYETALSAPSSPTRKFSVPTIKHTASTNSFCNSFNGLVNNSIPGAELTRSGASQSSVAPQTIQPEAPERRRFSIQSRRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H1</accession>
    <name>A0A0B1P6H1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative f1 atpase assembly protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6H1"/>
    <dbReference type="HOGENOM" id="CLU_054226_1_0_1"/>
    <dbReference type="OMA" id="FLQWGFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="307" mass="35508" checksum="2D1E29DF42B19318" modified="2015-03-04" version="1">MLSIRDLIFRLRPHPLMIQKRWAQVHNVRFRYLATNRDHLFEKYREKLDKKAKELGLQDTNELRDVYKEKIDTLKKDLCASLNLSSTPQEIHSKNTFSSSIQPPLPSPPKNSARSSLTPAIKNLSAYIDVDKTRALPLKEIEAIWRLRNMKNAQSLCAVIPLPLYQRMEGLARKYPSFILPLLRENQGAEIHYLQWTFPAENVVTILVTHLAEFKLRGEYSQPHTTITHHLDMAEDKEIVLLQGNVTEGRGVSVDEAKWLLFCLQRFYGGLGEDEKRGKKKEMVEMFGRGDISFNIEELIQEAEKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6J5</accession>
    <name>A0A0B1P6J5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001974">
        <property type="protein sequence ID" value="KHJ32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6J5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6J5"/>
    <dbReference type="HOGENOM" id="CLU_009058_1_0_1"/>
    <dbReference type="OMA" id="RETKMLI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000037">
        <property type="entry name" value="Sorting nexin mvp-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="329"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="707" mass="80399" checksum="7908CF0CA9C136ED" modified="2015-03-04" version="1">MSLFGTSPNDSVRAVDQNPRNSLFDDDLSIGGRNGSRTSSLSNENISDSTYLIQKAQKIDQADTDTTQRNLPLITAVQENYDEIYKIFSKNDDNITEEINKETVKKVLSKSNLPSEDEQSILEKIYQGGQLSALTKHQFYVLLALIALAQAHEEITLNGLNDRQNLPVPKLSGISSSSRLSSNFDEIPSQSNAKSNPQKYIGEEICITSDAELWASPIPNHNNQTLPSGTNEAVDGASNFQTPKTNRLSYNPPSGLSRRSDGNLDREEESKPDSNRTYGFGNFRDSYKTVNKQYSNIDKPVGNSSKNSLSQNTHHQTYNGVQAKSVGPEETIVVTLLPEKEGIFLFQHHCYHVINVQKGHKVVRRFSDFVWLLDCLQKRFPFRQLPLLPPKRVGLNGNHLATDKTFIEKRRRGLSRFTNALIRHPVLSQDKLVIDFLTLITEFSVWRKQASITIQDEFSGRSLPPDLEESLPLNLNDMFERSRTGIRRSAGIYTTLCVLMDRLIKRNEGFAAEQSRISRSLVSLSDASEDTYSIVVNDVPLLKKIFINSAKHLNDSQALLNDEAKAWDLGVLEELKKQRDSLVSMRELFDRRDKYDVDNIPFLERRILKNKNKLAEIIDKKEEMAKSGEVGRLTEAISKDNRSIVSQNARGIFVKECIFDELKYFQQTQYNICTWNKDWAYERVKYSELQADNWKQLNEVLECINIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N2</accession>
    <name>A0A0B1P6N2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative guanine-nucleotide exchange factor cdc24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001954">
        <property type="protein sequence ID" value="KHJ32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N2"/>
    <dbReference type="HOGENOM" id="CLU_007879_1_0_1"/>
    <dbReference type="OMA" id="QPIYPRQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000364">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="260"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112592" checksum="1AF7B71F7C767323" modified="2015-03-04" version="1">MSSPGVATYMAYTHGPLIETQAASAYNTKRGIVNGIPGINQTMTQTLSNSSRLSQSSGSTAHASSSTTSLSSMTSSATLVASNSMSQNGGQVVATNNIINQRADASRSLYQICVNLRFRLSKVPGLNEHLNDSDDEDQGEETDPVSSLWRFLRKGTPLLTIYNCLQQPEILKLDENMPVMKRPKIAAFKFVEACLKGDLQIPPGDCFSLQDLFGDDTTGFVKVTQVINIVLDVAEQRGLLLTSEKDDFTPADMPGTQMSYRDHVVRELVDTERKYVQDLENLHELKKTIEQKGVIPGDLIHNIFLNINAILDFQRRFLIKIETTNSQPEKDQKWGLPFINFEEAFGIYQPFIANQRKSASIAKREFDKISLADHPVVVDFNTLDGFLLKPMQRLVKYPLLLKDLRDKTNANEATKNDLTLGIEAANRVLKLANEAVDRELRQEALNDLCARVDDWKSHRVDHFGELLLHGNFPVVTGKSDVQKEYTIYLFERILLCCKDMNPNKSKEKLIPSQKDKKDKKDKNKKEPYRNSKLQLKGRIFMTNVTEVLSLAKLGSYTVQIFWKADPGIENFIIRFTNEEIMKKWYEGVDTQRKQNANYPSSNSSTESQPPVFTWNSQAGQPENPYVQHDENDYEEISNEQIPVSIAPNSTYPGPPSSLRGRAAPGENLQPIVGFTRTLGPRFPVGPISSLSLQTQISPSPHGGDSYFSPSTEPISESPNSSRTSGTSSIFPFPRQIIPQNGWEENTRYTAPAMPRAPSRGSQNPGESYQMSGRSPQRPSLPAMSKSQTNAAMQRNRSYSTPDINNVQSGARRVPNGALSQVPAVPGIPAHLHHAYDSGISRSQNNISIRCNTQSPGIIRDRTNPSQLQYTNVQYNRSNVNQVSTTSSEGRTISSAIARPSSVESDIGLPTQLKVKVNCDGNYVTLVVAFNITYQSLIDRIDAKIGRFSNNAISQGTMRLRYRDEDEDFVTIESDDDIQIAFQEWRESQKQQYQQGSLGEIELFCLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Q9</accession>
    <name>A0A0B1P6Q9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001937">
        <property type="protein sequence ID" value="KHJ32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Q9"/>
    <dbReference type="HOGENOM" id="CLU_085828_0_0_1"/>
    <dbReference type="OMA" id="RYMNQFI"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="18567" checksum="60EF73ECEE310009" modified="2015-03-04" version="1">MSYYFAIIGTQDNCLFEYEFGTAKQGGDGIARFPEQARHMNQFIIHSSLDIVEEVQWSTGQMYLKVIDKFYNNYISCYITGGNVKFLLLHAPSQPAASHTSRNNTSIAANPNSPQTEEAIKQFFTEVYENWVKAIMNPFYHVNMEVKSPTFRARVAAAGKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T6</accession>
    <name>A0A0B1P6T6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000894">
        <property type="protein sequence ID" value="KHJ34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T6"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="49540" checksum="C6542E2746FA36C4" modified="2015-03-04" version="1">MICTTTISCIDSALANFKEEIEKEVVAFKDYLQSAIANFAAVDTSPTPPKIPTHSRPGKESSYGSGKGKNTTNKVAIATPRNMKSVASFEGTSQETSKLPKIPQISENTWATVARNGKKKARVITNTKAQMTPTRKTIQTLPNTQKSSTTTLVDKRLFVRLPLDHEWRKLSPAGIREVVVQKLAISPTLFGKIKPVKSGFALSPCSTEAREAMLNAGNRLFLTGAKLEPSANWIPMIIPTVPSTIRKVQGQIEVSNSMLTDEVERVCAIRPAHVKLYGGNKAEAPHKTWMAYFSKAPRAGFRVFDESGITRPFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHTEDLCMATTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMRTFRQIGEREYQAVLRAKAAEESAVFAENNIMDLTSSQDSEVGGDTDNILASPVENSKDGALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A0</accession>
    <name>A0A0B1P7A0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7A0"/>
    <dbReference type="HOGENOM" id="CLU_443585_0_0_1"/>
    <dbReference type="OMA" id="SHKSEPK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="616" mass="67059" checksum="25A6C50AE20E6FDC" modified="2015-03-04" version="1">MAVVQNLKAIFERSNESISPDRGRSGASSASGIETPTRPLSKIRTSFVSVERIGNRSISKERRILIRSSSTNECENPNFLDIYNNNKKITTGESNLNFKSSIGQRNAASIMKDEEKQIDLKRANDSSVISISKDSNKINAIQGDKISKLNASPLSLKNTTLSNSSKGASQRNPATPTSRNIDIRGNEVKSIQKSTNSKTGSYSSIRSKPENTPAHSKNHNQETSQLVRVKRLTPKSPTRPVKLPPSLTTHTASSSSKTANAVSSTFSQPSLRRVSSNFQQSISSQRRMSIASNISLMPKYQVKKNHSDSRTHLDSSKKTLTQSTLPQSATTELSFLARMTRPTASSSSKTTDKLPTSKKNSMNTRPTTKNASKTTSHKSEPKKNTSAMKRDKKPDIPTAKNINVSTSKMSKKKTLQSTSNSTTAEHKNKSSSSKIALNDKESGDPFTSFEPNGCNNKMDDEKSLDVPVNQPKESPKKSVQEFLTNTSSLNTDPIDDFKEAIVFKGNVSGTEAENPTSLGESDLDLSNCKEAIVFKSNVSGTEAENPTSLGESDLDLSNCKEAIVFKSNVSGTEAENPTSLGENDLDSFNCKEAGEMEDQNSGDSTVNKTLLDYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C7</accession>
    <name>A0A0B1P7C7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hemolysin-iii family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001807">
        <property type="protein sequence ID" value="KHJ32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7C7"/>
    <dbReference type="HOGENOM" id="CLU_029962_0_0_1"/>
    <dbReference type="OMA" id="SRWTYIL"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="489" mass="54690" checksum="883652C55EC97D55" modified="2015-03-04" version="1">MAVCTTPSLTLESYDEIHTGKTTTLDSTKPRSYRRRHSSFHPRQLCHEYIGDVNEGLLLKLDQFLEELERRLDYLESFGNLHVDAGISRAYTTLQAVRARCSQVSGEMITAGRKKARIMVETVESRYQHTLAAKATLNEKVHEGISLLENTLCDFERKASQMKDQGFIGAAGTLMGGGRRVVDEGIERAKKAAGSMEVHIQSAILRAKEHGLICYEDLPIPWRVNPHITKGYRFTESKLECVHSIFGISNESVNIWSHAVGLFIVLSIAFHYYPTSVNFSQSTTADICIAAVFFFAACKCLVCSTMWHTMNSVADQTLMERFACVDYTGISLLIAASIMTTEYTAFYCEPVSQWIYLTLTGLLGIGGVILPWHPTFNRADMAWARVAFYMSLGATGLGPAFQLLMNQGFSYAWQFYAPIAKSLLVYTLGAIVYASQVPEKWYPGAFDYIGGSHNLWHFAVLLGILFHYLAMQEFFSSAFQRAVDGCGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7S4</accession>
    <name>A0A0B1P7S4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peroxisomal-coenzyme a synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001862">
        <property type="protein sequence ID" value="KHJ32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7S4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7S4"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="OMA" id="TFRGYYR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="426"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="57459" checksum="F7214B8022564455" modified="2015-03-04" version="1">MDSAHINWASTLFNAFPYTDHATAIIVPGEEPTTISYKNMASEILSFQIKLALLGVTVESAVSIAFPNSYEFVISFLASTSQRAIAAPLNPQYKQEEFEFYIGDLNSTLLLVPKGSFDRNTPAVRAARNFNTAIAECYWNGREMILDLKDGGKLNGKGNQKIERARPNDIALILHTSGTTGRPKAVPLTHRNLIKSMKNIRTTYALTSHDRSFLVMPLFHVHGLLAGFLAPLFAGGSVVIPSKFSASKFWTDFISCKANWYTAVPTIHQILLNSSPPNPKPSIRFIRSCSSPLSPTVFHKLEEAFGAPVLEAYAMTEAAHQMTSNPLPPEKRIPGSVGMAQGVDIKIFNENGDKVSIDEEGEICVKGENVTAGYLNNPIANKSAFTKDGFFKTGDQGRLDENGYLYITGRIKELINKGGEKISPIELDNVLLQHSKIDEAVSFAIPDSIYGENIAVAVVAKKNEKVTEEDVKAWIKNRLADFKVPKIVHITDKIVKTATGKIQRRLVAEEFSRQQKIMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Z2</accession>
    <name>A0A0B1P7Z2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Z2"/>
    <dbReference type="HOGENOM" id="CLU_2387801_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061955" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10665" checksum="608E83446C78E889" modified="2015-03-04" version="1">MSRILHAKVTIVLFATIISSDSTFPSIAFESLFVEETIFETDSVVFFIFLDIIASMTSKQLVEFKSFATKKGTALLLIKVREKDFCFFPPVKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P847</accession>
    <name>A0A0B1P847_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodopsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Rhabdomere membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000876">
        <property type="protein sequence ID" value="KHJ34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P847"/>
    <dbReference type="STRING" id="52586.A0A0B1P847"/>
    <dbReference type="HOGENOM" id="CLU_060150_0_0_1"/>
    <dbReference type="OMA" id="RWNDQYK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006031">
        <property type="entry name" value="XYPPX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31248">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G04290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31248:SF2">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G04290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02162">
        <property type="entry name" value="XYPPX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00239">
        <property type="entry name" value="RHODOPSNTAIL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="30363" checksum="05D3F0A134D347BC" modified="2015-03-04" version="1">MSDNFVPPPGPPPTASPQVPEGYKAQWNEQYKEWFYVNIYTKKSQWEKPKEPAYPNTEVSPPGPPPGYTSDTKEKISDVKEPSQDGTRNTVDSAPGYAQQSLPPREQKPKQGFLGKLLGKANGGSAASGQMNQPPQYGYPQQGYPAQSYPPQGYPPQGYPPQGYPPQGYPQQGYPPQGYPPQGYPQQGYPPQGYPPQGYPPQGYPPQGYPPQGYPQAYGQPAKAKTGGGLGMAGGAALGVGAGLVGGMLLEDAIESHEERIYEQGYQDAQNDDGDFGDDGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P871</accession>
    <name>A0A0B1P871_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P871"/>
    <dbReference type="STRING" id="52586.A0A0B1P871"/>
    <dbReference type="HOGENOM" id="CLU_036959_0_1_1"/>
    <dbReference type="OMA" id="GAWVNNP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="9">
        <location>
            <begin position="71"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="36273" checksum="7C76A9140B62F021" modified="2015-03-04" version="1">MTDSKDFGVVRKEIAKLLHKPGYDDGSAGPVLVRLAWHSAGTYDFETDTGGSNGAGMRYEAEGGDPANAGLEHARVFLEPVKEAYPWITYADLWTLAGVVAIEEMGGPSIPWKGGRTDYVDDSKLPPRGRLPDAAQGAEHLRFIFYRMGFNDQEIVALSGAHNLGRCHMDRSGFEGAWVNNPTRFSNQYFRLLLSLQWLKKKLSNGVEQYVNYDEDSETELMMLPTDIALTQDHEFRKWVEIYARDKGLFFKDFSKAFAKLIELGIVRDCDGKIINVDEQKGGYYSAPKKSNKPGAISKPHKGIAKNTCAKDLLLDENVDVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P892</accession>
    <name>A0A0B1P892_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">EV44_g3013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P892"/>
    <dbReference type="STRING" id="52586.A0A0B1P892"/>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="238" mass="27886" checksum="FC13BD36DB795530" modified="2015-03-04" version="1">MNDDDDEMPVLSDSTLIALQEFYAERTALEDSNNLFHHGLNMDIFTENWQYSQFWYDEETARKLATAVLSNASKGETIAMISAPSAYVMAKKLLIESGRPQTSWPKIILLEFDRRFKIFKDEFVFYDFKNPMQLPSELKGSINHIICDPPFLSDDCQTKVAISVKWLSKSWEIMPESRAEESRLVICTGERMEKTIQKLYQKRGIFRTNFEPTHTKQQLSNEFLCFANFECTQWLWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8I3</accession>
    <name>A0A0B1P8I3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001697">
        <property type="protein sequence ID" value="KHJ32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8I3"/>
    <dbReference type="HOGENOM" id="CLU_1042790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="267" mass="29906" checksum="223E519D733FAA15" modified="2015-03-04" version="1">MIRLDKNNPMREYRPFTIMKKVNETLGDSLCVKDAYATGSGVALVAADDSKVHKILQAKDQLKVVFSATEVERQESWVTFLVQPVPKNVQSILGNDLQVDENALVEETERITGCRPTRAHWTAKSKDPTKPEGTVVLSFQTSSKPHWPKVIRFFGSPTTVQKLSIKKPLTQCDNCYGFHHSRNCFRTAHCAHCSRPKHAGSRPTPCTSHICPPRCINCRGPHKANFTECPLRPSRIHGVFYKLNSRQIRAVRTAGGIAWAQAHALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K1</accession>
    <name>A0A0B1P8K1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001687">
        <property type="protein sequence ID" value="KHJ32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8K1"/>
    <dbReference type="HOGENOM" id="CLU_644350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="285"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="414" mass="46778" checksum="B76A27804575124B" modified="2015-03-04" version="1">MVQDEKKPSPEASQDLVILGITLATADDLADSIEESYKKTAVYTLSERLHNIAAMSPIPKLKTMNWRHWHESVQTLLSLSQTSAVFQKNPPSNRAIKLWSIWWSSKLRETAPHIQSAPSDNARDILKEIIIDSQAQIVTSVLNVTARFWNYKPGNNITSYSYIKEFQKRLHELREHTNISSDVKIQAKNLLLYHINTKWPDLMSRCKNLSLEQTLSECLSGTSADRPSNKNKNKSVIKCNFCNNLGHSIDECRKKQKSEKNKNKNSSGSKILSVNKPTETSCYQLDTAADFHVCGNEDDFSSYFKSSQLIGVAGGGQVTTDGHGDMFLPTSDSKLEILNGAIHLSGENTHILSTSQLEKQGFSIYWPSNYQDIELLRPDGTTCAYFRREAGKLLWKPKHVETVKPSMQRSQNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N8</accession>
    <name>A0A0B1P8N8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001660">
        <property type="protein sequence ID" value="KHJ33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N8"/>
    <dbReference type="HOGENOM" id="CLU_1090685_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="29092" checksum="440E9744FFEF8F44" modified="2015-03-04" version="1">MRGLRLFNSRMVNEIKGKATPNPYEKSRLVIQAYHDLEKSNLLTQSPTIQRASQRLILVLTPSLLSTCSLCLRDISQAYVQSSTKLNREIIAKPPAEIASQMPENSVLKILKPLYGIPEAGTHWYNTYHKHHCEKLFMKTSTYDPCLLISDKKEIFGLVGMQTDDTLILGNKNFILLENDEIINANLLAKPIQTLSSENPLVFNGCILTFDEKDKSIKLLQKDQGKRIELIDDKLLTYKQDYFICRCTKSKSNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R8</accession>
    <name>A0A0B1P8R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rrm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R8"/>
    <dbReference type="HOGENOM" id="CLU_033916_1_1_1"/>
    <dbReference type="OMA" id="WNTDDDI"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="42901" checksum="194D61A52204CAD9" modified="2015-03-04" version="1">MADDEFDIDIYGDANTVQEKESNVYQSEERTETKSCAENFNIHKSDEEQEDDYVDIKVNSNGLGKPNERQKIKSTDESGQETLNIPKQAPQQQGVKRKDGSDDRPIDSGATTALLISELNWWNTDDDIRGWINQAQVEDELKEITFSEHKVNGKSKGQAWVEFTSQQAATAVKRKIDGFGDGQPYARKHIVTFSNPNVNPFRTLPKDAPLRSGKDTQISRTQSGNYNSDRGNHSGNFSGNFRGRPSGYITRGGINSHNMNNFNRNFSGQFMGNMGSGFNNTMNGFPGNPMGNHFGGFNNRGGIMGNMRGGGGMRGGRGSMGNGMMGGLPLGGLQMGGMSSMGGMSMGMGNMAGAIPGAGFQGMQPHFNPAFFPSNQAAGTDWQNPHGVKRQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T5</accession>
    <name>A0A0B1P8T5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pumilio-family rna binding repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001259">
        <property type="protein sequence ID" value="KHJ33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8T5"/>
    <dbReference type="HOGENOM" id="CLU_009803_0_0_1"/>
    <dbReference type="OMA" id="FASEYSM"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="420"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="483"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="708"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="806" mass="89104" checksum="EAA9AB521EA4F75A" modified="2015-03-04" version="1">MSGNVFTGSPQSRRATDGRSISQENSGLNGDELVSSLEQNDALLKKSVTTLSSSKLGNQAAPKKLKLKHDISSGSSESDPMEKLLAKLSQQQAAINQQHEALRSSDDSITYSRTADYASASSSTPITPELTEPYNGATANSSSSEVGKVRYTPNIGELTRLKFELEAAKGKIARMDQELAQTRITKHTLDQAIGSASEADLSFINIHGKDFHNFHPSHNGPPHSQHENSWGIKDDNRSDTSESLSASGFNHSRSIWGSMQKSTFNGSQTGAQPFQQQPSSTLDHTQYLGRNYIQPYLETSIAYSSTPINGFRGDRMLPETELIMNQTMNRRAPISGRFSNRSNGLTQYSSSNCSFDGFANSSAGGISGGSIALGTGLNPNMNSNLNLCSNYHPLPIGTPLSPHAPEFTSSSNWKGDVVATEGSTYLPTTEPLNYRRLLDRTVNCNWKYIVDKIVCNNDQQASIFLQQKLKVGTLEQKYDIVEAIVAQAYPLMVNRFGNFLVQRCFEHGTPAQVIKIAEAIRGQTLNLSMDAFGCHVVQKAFDSVPEDYKAVMVHELLRRIPETVIHRYACHVWQKLFELRWTESPPQIMKYVNDALQGMWHEVALGETGSLVVQNIFENCLELDKRPCIEEVLASIDIVAHGQFGNWCIQHICEHGVPADRSRAIDHVIRYASEYSMDQFASKVVEKCLKIGGSEFLSRYLDRVCEGRLDRPRIPLIEIASDQYGNYLIQYILTHSNPQHREIVAQHIRKHMVSLRGSKFGSRVGMLCTNPAIQTRPGPGVGPAIGAPSRTSLGPQQGPRYTGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U3</accession>
    <name>A0A0B1P8U3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000758">
        <property type="protein sequence ID" value="KHJ34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8U3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8U3"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="346" mass="38306" checksum="C57FEB261940A10A" modified="2015-03-04" version="1">MAKTIHAHLRTAISQFAISETCAPPLEFSQQTKGVKINAISNMNLPKKPTVAATHRINATLKTANALPKVPKTTPMLWTTVVRNGQKKTRLNEVPDATTDTNLQPQKCAAKTTFNIAQNQNQSQKNKKQLKSTDDMRLFVRLSKEHEWRKLSPAGIRDVVVKKLSISPTSIGLIKPVRTGFALSPRNNEAREALLKLSLRLSSFGAKLEPATSWLPVIIPTVPRYIRTEKGQVEVTKELLSDEIERVTSMRPNSIKLNCGGPHRSDSRKCLARPTRNGAPTKEQLKSIRLAGDRKFQAVLRAKAAEERASVLEGNSDEEPIQPEVVDMENTQASSVEDTVGDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8U7</accession>
    <name>A0A0B1P8U7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative translation initiation factor eif4e3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001255">
        <property type="protein sequence ID" value="KHJ33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8U7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8U7"/>
    <dbReference type="HOGENOM" id="CLU_043552_0_0_1"/>
    <dbReference type="OMA" id="DNANLWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="336" mass="37291" checksum="AAA1D1BA14366F30" modified="2015-03-04" version="1">MDNLWARRSNNSKLSLSTSSPNSGSISTQDHLNKNNALNRRNGDSSHHNNKNLFNSIPLSSASLTSPTNGASSAFGLGTGAFASFGTSKAPKSNGSTPELSCIGGISKSPSAEACVLNEKQSKENNSGQSTTNFSTSSSHPLRYNWVVWFRPPIAKSNGYIQYEKTLHPIAGFSNAEDFFTVYRHLKRPSALPPVSDYHLFKKGVRPVWEDNENRKGGKWIVRLKKGLSDRYWEDLIFAIVGDQFAEASEEVCGAVLSVRNGEDILSIWARNDGGRVLKIRETMKRILGFPPDTKVEWKSHDSSIQQRTAIDEHRKEKYNHHNSNTGRNSNRPAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P907</accession>
    <name>A0A0B1P907_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4569</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="JNVN01000488">
        <property type="protein sequence ID" value="KHJ35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P907"/>
    <dbReference type="STRING" id="52586.A0A0B1P907"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="55"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="357"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="445" mass="48390" checksum="F7F80107557E75E6" modified="2015-03-04" version="1">MIRIRPQLRSTRSVLINRFAPQTCSAPYLRAPRGCFSTSVAFAINEQSSLAKTPLYDLHVSHGGNMVGFGGYLMPLQYTGLSIIASHHFTRENASLFDVSHMVQHSITGPGAREFLERVTPSDLKGLPHRTGGLSVFLWPKSGGIVDDTIITRLDSESFYVVTNAGCRQKDLEYLGNELQAFQKSGGNEVKWNVLDNHGLVALQGPRSEEILSNVIVSAEITSLKDLYFTQSTYIKIKISNNATSEPLLVTRGGYTGEDGFEISIPNKEIVDVVEVLLKSATSDKLQLAGLGARDSLRLEAGMCLYGHDLDDKTTPVEAGLSWVIGKSRKLDGNFNGADVILPQLIPRSRGGLGVTRRRVGIIVEGAPAREGAKIIDLDGAEIGNVTSGCPSPSLGKNISMGYIKDGFHRSGTHVKVLVRGKKREAHVTKMPFLPTKYWKGPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A0</accession>
    <name>A0A0B1P9A0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A0"/>
    <dbReference type="HOGENOM" id="CLU_021479_0_0_1"/>
    <dbReference type="OMA" id="IWVGATN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="200"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="775" mass="85018" checksum="72FC4C9F10168F6A" modified="2015-03-04" version="1">MVPTSPRLRVLSVGGNAISAFLSWRLQATNACDVTLVWKSGFDAVSQYGISFKSTTFGNERFKPRHVVKVPEDVAIQNKGAFDYVLLCVKALPDVYDMASVIESVVTPKHTCILVNTTHTLGIEAQLETRFPSNVILSLVCGAEITQLGASEFEHKGSTEIWVGPSNRNSTISKSSQVSMADALAITLVSGQIDCRLSENIRQQQYERMIGPIAFHPLSVVFDTPSHASLIEKVGVRIMIQEILDELLSIATAQECTFVPDFKEKTIEEMIRPSSFNSIMFQDYAARRPMEVETYLGSPIKQAQITGVRVPRIETIYAILHNLNIANQQRKDYPITSPNLNTSNTRMSMAPPTSRAMNNGHMNMNSSILGPGPAGRGRGRASTMNIPQPPVTRRGYPINGINGSQTNGYLRSAIGPNGQQAQRIPSRIGSMEGNDLEEFSHLVLFDDIPESGENGYTAELSQIALRERELALRQREIALREQEMRLKSVGIAPRGSRRVQKPPSIKNVGFDEDDDDDYIDPTDGPVSLPLIDPDNFDMMSLTTRRHRKAIPNEREIRKNPGMGDIIPSIRRSNGFGLRHGFSRNRSSARIISPSPGNLHLNLMDDQLIGYSSNRYGNVDRAQMGLESRSNSLTATRLDELQNNGLMPGVFTNQRRKSNSPGNANSPVQSKAGSRKPSPPHGQPGAHSGGKPSPSGAPRQQFPRNPLVQAKSPSPHQIDQYSGVSAIPSNGPTNYQNLTGNANDSTGSIENFNHDSESTVNNNQCNLGNRPPIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F0</accession>
    <name>A0A0B1P9F0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">At2g23090-like zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000448">
        <property type="protein sequence ID" value="KHJ35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F0"/>
    <dbReference type="HOGENOM" id="CLU_181109_1_0_1"/>
    <dbReference type="OMA" id="VICKVCY"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="74" mass="8260" checksum="184565CD272923BD" modified="2015-03-04" version="1">MGNGAKAASKRDRKEKLVKPAKSQLKSNEKAKDIQCCVCKLTFLKTARAPALEEHSVQKHKKTIKDCFPNFEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F9</accession>
    <name>A0A0B1P9F9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F9"/>
    <dbReference type="HOGENOM" id="CLU_115072_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17934" checksum="0BE87BAB8B049B11" modified="2015-03-04" version="1">MRTENYVESESEEESISLEAFLTGPARKHQRSEQGRIEVQDLPNSESSSRTRKQKTSVGKPEKNGMKVVKALREIVGREGLGPLNYKALAEKINVPLNLLEFFQASPDAAKELRKMSQRLNIRKGPRPGNKAKKKAKISADSASVEVDRKNTESRETLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Q0</accession>
    <name>A0A0B1P9Q0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative camp-mediated signaling protein sok1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000594">
        <property type="protein sequence ID" value="KHJ34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Q0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Q0"/>
    <dbReference type="HOGENOM" id="CLU_016970_2_1_1"/>
    <dbReference type="OMA" id="LHWRVWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="676" mass="76728" checksum="0F85E66A643C5968" modified="2015-03-04" version="1">MESDANKRQRENSITATSNGHSNSPDGTDSGPVGATSSGNDHGRQTSLERCIEDQTYISGTHRDKVVGNPHPRSQRIFAGPLEQSSRSSSREKLPSSEPPVTKVTLSELDVTKIINNPKLRHDINFDPDLHFRPNLDGDKGKRKAQKGNEFWETMRRKLQQFLINRDQFDREHGNVEWCLPATLKAIRAILETLVPPQDCAIIDESFNVNLLMQQFRKGVADIPKLALWLSQLLKSHCAPMRDSWVDEMAQQLSDGDRNYDVGLLVTGIKSLLAVLEAMKLDIANHQIRCLRPALIDNTVEFEQKFFARKIKVGRLDASLAHDWYKRSCSIHSHPSIDNLRHSRGNPWNFLRALVNLILPTNDVEVIPHTFLFDEERLMKLRSDMLDLINLEVCMFHYHCLKASSRTTCESQIFTDDTPNTSFVSSPLFQPSSPEKSTILSSPTLPLPDDFSSSYLRQNYKTRKIERDHNDFRMFMSKADHTFVASNDSSPASSPSSTPSLPDACSPTRFLFPQTATDSTTALRSSLLAILASSPSPINPIQKWHKLAPDLALQVLRSTNTPFTQLQNFETQLSWNLSETRSRVFRLVENCVVSKLLPELHRLVESYIPKTTFQIFEAATTPKVRHRAFTQTGPNEDILEMATRIAHLGVLHWQVWGEWFYQQKLEDFYAIVVANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9R6</accession>
    <name>A0A0B1P9R6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative c2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P9R6"/>
    <dbReference type="HOGENOM" id="CLU_003023_0_0_1"/>
    <dbReference type="OMA" id="VLKSPKW"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="690"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="891"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1352" mass="155281" checksum="F1EA967AC34F51AC" modified="2015-03-04" version="1">MSFNSSKSRPNARNHSLHSSDRLSRNSSRMRPKPISYNDAYTYALRVAYLHHLLQKRTKGKQFIIPSKPPKKVVSVGDLIQDFSLTRDSTSTKLPHGFMSLLERRIQGVLTGKEKIPEFNDANVKRVFAEAYTAFTEQGFRKRMDKERRVEDLVLIFYSSAIKALQKGQTGEDNSWKLSVDRHVALFVQLISSTLKLNGNEKNKPELMTKLTTLEGKLLTNDRNLFVDHSGPVGSNVEAGTQLSYDIKDMAMVQVVARIFGLKLSQVQSDIDAQRFVWTHEAAISDLKAYQHCLRTNTKRTLRSEDFDVDEGYSAWLKAEGPELYQLIAEILRVRPSLANTFNLNQAVHQARTTTSNPDDQAYSDLARTITNSSDQNSSIIFDQPFDMSVLSLEDEQPARICLEETSYTFIPSDPRGFFRSILSHAMIYDQLHGTESIGDLEITPLLSRDSIDLLTELSIRWRIPQFSRLVIFLDVAAQKFLDQEIGLEELDSAFEFVKNPPPETKRFAGSLLSFDQTLWTIQDFALYRQTLSSLNDGLSRDLYELLQHYYDSRPLSPGPVLLILESHLHSDPSFSVSTEEMENFRAQLEVGLRTKAASVYREFLEAEVPQHQEQWEFGHVVQLGKSVVKLCERTRKRYRENPEIMGVNPLTILVETMFPSFENDAGDLIQRILHVAKDKNSEIDLEDGFALYKELVEIRQIHRTALPEQPFAFNIEELLADFVWRWIQVADSRMVELVDQAIKHDNFEVRPHNPTNSVIDDRRHSVSIIDVFRLFNETVNQIFQLNWDNDVQYAEFMTALSKSFGTGIARYCERIEQMFSKEMDRLSPAQEAVVLQTKQEKWMQLAKDAWNNKEKIEPFQFYPESLVKLNNIEFALQQLDILEKTMNVDACAEVLAKVNPIKEKQKPSKYVFTIKIVEAEDIKACDANGTSDSYVVLGDEFQKRLAKTRVIVKSLYPRWDESIDITVQGPLNIIATIWDWDAFGDHEYIGRTSLKLDPIHFSDYLPREYWLNLDTQGRLLLRVSMEGERDDIQFYLGKSFRLLKRTERDMTRIITDKLSQYINTCLSQEALRQLLSRGLSVAAVTNLWKSRQTTAPVMTQIDVENALKPLFTYFDENFAIMKETLTEDSMVMVMNRLWKEVLLALECLLVPPLSDKLSSQKPLSQHELDVVFKWLELLFDFFHARDDHTGEAMGVPANVLKSPKYHELASLNFFYFDTTDNLIRISERMATASAQRANQHRSRLSAPPSFGASISGLPAGTSIRRTKSIMMSRNLGTMRKAKEEKRKEAQADPNDDMILRILRMRPEAANYLKDRSRQKERLAAAAAADMIVRQSLAYNVNKFGIGNMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9T4</accession>
    <name>A0A0B1P9T4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001055">
        <property type="protein sequence ID" value="KHJ34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9T4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9T4"/>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="OMA" id="NEAAMDM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080565" description="Citrate synthase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="51691" checksum="C9B5556E434BD383" modified="2015-03-04" version="1">MSLRNLLTLTLGPLSVSVRTYANVTSDIKEGIKARVDEKRELLKNIKVHGDKNIGNLKVAHVYGGMRGLTSMLWEGSVLDPNEGIRFHGRTIKDCQRELPKGKSGKEMLPEAMFLLLLTGDVPSISQTRQFSRDLATNAHLPPFVEELLDRFPKNVHPMNQFSIAVSALSTTSEFANAYETGCDRSQLWLPALNDCISLIAKLPVIAAKIYQNTYRGVGPLPAIIDPEQDWSYNFAAMLGKGGKRNEDFQDFLRLYLALHGDHEGGNVSSHTTHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWIQMMEENMGPNYTVDDMLKFFQQTLESGKVIPGYGHAVLRRADPRFEALMEYATSRPIANDPTFKLVKKVSEHAPQFLKMNCRIQCPYPNVDASSGVIFHYYGFRETLYYTVIFGVSRALGALSQYIWDRALGLPIERPKSINMESLLKKIELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAJ7</accession>
    <name>A0A0B1PAJ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sh3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000452">
        <property type="protein sequence ID" value="KHJ35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAJ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAJ7"/>
    <dbReference type="HOGENOM" id="CLU_064525_1_0_1"/>
    <dbReference type="OMA" id="EWWKGRN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28009" checksum="95623F725F88CC27" modified="2015-03-04" version="1">MSASLVSEERQRIINNNRSLRTIKNELESLAERGAISDDVYDTIMSALPAESPLNSNSARGNITKNNVVVDPSPSPADPPSLAMGNLCLNNEPTPSPASVPLTAPTKVEIARANALYRYAEAGDCNFEVGDTIIVYEYMNQDWWLGKNLRTGQEGVFPQNYVQRLPHPAQGPYMNEKGGIYQNGFPPPYQQQMQPSAPPPSGPINPYNSSVPPMQIAEQPSESKMGKGGEMGKKFGKKLGNAAIFGAGATIGGNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAM2</accession>
    <name>A0A0B1PAM2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative aarp2cn domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001096">
        <property type="protein sequence ID" value="KHJ34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAM2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAM2"/>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="63"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1098" mass="126256" checksum="92A29994A53D42F0" modified="2015-03-04" version="1">MEQQANAPHRPSKTKKKHTGDRNPKAFSFSNPGRLSKTAARSHDIREKKLHVPQVDRLPDEPPPRLVAIVGPPGVGKTTLLKSLIKRYAKETLSEPQGPITVITSKRQRLTLIECPTQLEAMMDISKVADIILLMIDGKFGFEMETMEFLNILAASGMPGNVFGILTHLDLFQKPQTLKDTKKKLKNRFWSELYQGAHLFYLSGVINGRYPDREIHNISRFISVMKNPRPLIWRNSHPYSLIDSFRDITHPTKIESNPKCDRTVVLCGYLRGTNFAPENQRIHIPGLGDFSVSRIETLPDPCPTPYMDQAIAKASGSKGRKRLDEKDKKLHAPMSDRGGLKVDGDVIWITKEKDFSFDKDAVNKDLGEGEELIINLQHERKLLGQTEQGLRLFSGEDTVINKTDIYKSERDPRRKAFADEEIIENNIMYASLDESSDQSADKDTDESIDQSADESADKDTDESTDESVDQSADDNIEEEDSDEMLSARWKENSLLNMQRINETKRPLRTFELSKMIYDTSLSTSEALGKFQGKEDTSNYLEDNKEDIFFEKSKIENEIEENDRVMSLFNYEELEKKWTLEENVENLRRRFTNSELLPKEDKISQYDSDEGDGHFEDLEQLKPSDIDAERETNARRKEELKLRFEIEDREGLNNEKAQALKDNADNREFGEDEWYEAQKANIQKQLNINKAELEALDDNQRLNVEGFPAGKYAKITIDGVSSEFVTKFNPKMPIIAGGLNATEDRFGFVEVRIKRHRWHKKILKTNDPLIFSMGWRRFQTIPIYSTSDSRVRKRMLKYTPEHTHCFATFYGPLISPNTGFSCVRSLPSKEAGFRVAATGTVLNVEEGTEIVKKLKLTGTPYKIFKNTAFIKDMFTTSVEIAKYEGALIRTVSGVRGQIKKALSKPEGHFRATFEDKILMSDIVFLRTWCPVKPHRFYSPVTNLIGWTGMRLTGEVRMAEGLKVPQQENSVYRPIKRVTRNFNPLKVPQKLAAELPFKSQITRMKKQKDKTYMQKRAVVLGGEEKAARDLMQKLMTLRNDKIDKRRKSKEANREAFRKKQAKNAEKREERTKKESQEYWRNEGKKRKTNTDETGPRKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAR5</accession>
    <name>A0A0B1PAR5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000265">
        <property type="protein sequence ID" value="KHJ35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAR5"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="28263" checksum="E66E690215B4DA94" modified="2015-03-04" version="1">MNNEVYLPNVPQTSDKTWAIVARKGQKKARVDNSIKTQITAGNKNAPRVLNKDNSITPVSDKRLFLRLPQEHEWKKLSPAGIREIVVKKLAISPSLIGKIKPVHSGFALSPSSIEARDKILDAGNGLFFSGAKLEEATNWVSVIIPTVAASIRKEQGEVEVSKIMLDDEVERVCSMRPAHLKLYGGNKAEAPHCTWMAFFSKALSSSFKVFDESGVARKFKKQQPLDFFKRCNGHHPTKNSSRAPSCGNCGSTNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB42</accession>
    <name>A0A0B1PB42_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000818">
        <property type="protein sequence ID" value="KHJ34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB42"/>
    <dbReference type="STRING" id="52586.A0A0B1PB42"/>
    <dbReference type="HOGENOM" id="CLU_054086_0_1_1"/>
    <dbReference type="OMA" id="FLWSDIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="35195" checksum="71F63CE729C498B7" modified="2015-03-04" version="1">MATRKLNEYLDISDSESNHETENESDAEEIKKGGRTPKRKKVENFLSDGEEPDSDQNNIEGGLKNINNNGKLRESSEEKDLSDTPKKSKPILKKNLVATNEAIKRSGVVYLSRIPPYMKASKLRSLLEPYGAINRIFLTPEDPSAHSRRIRNGGNKKRSFVDGWVEFVKKSEAKAACELLNARTIGGKKGTYYHDDVWNLLYLKGFKWNNLTEQIAAENAERASRMRAEISKTTKENKEFLKNVERAKVLRGIEAKKIAKSSNDKNSNITVVHANKPTERARIFKQRTMPSKHAPELQPERIKSILGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBA1</accession>
    <name>A0A0B1PBA1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000988">
        <property type="protein sequence ID" value="KHJ34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBA1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBA1"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="262" mass="29290" checksum="D9588B3B3B556AA2" modified="2015-03-04" version="1">MMDSTKIPLDTEKPLRRKAFVPIENNPEVMSTLIHRLGLSSELSFYDVFSIDDADLLAFIPRPAFALLLVFPVSEAYKKFRLKEDQDNPDNDAKETKESVIWYKQTIVNSCGIMAILHAASNGDSRKFISSGSPLDNLIKQALPLGPIERADLIYDFEALETAHHDAAYQGQSCAPSAEDDIDLHYVCFTKDKDNVLWELDGQRKGPLNRGNLGPEDDLLSEKSLNLSVRNFLQREEAAGNGEIRFSLIALAQSSICNQRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBD0</accession>
    <name>A0A0B1PBD0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000352">
        <property type="protein sequence ID" value="KHJ35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBD0"/>
    <dbReference type="HOGENOM" id="CLU_1295259_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="23598" checksum="FB5913D90B032C91" modified="2015-03-04" version="1">MICTTVISSIDTTLAIFTIEEEKEEIVAFKTYLNLAIANFAATDTSPTPTRVPLHSRPNKGNRNECSKGKSKEINLSKIVVATPRIASNQDPNSGTSKDIELPRIEARETILKAGNGLFLSGAKLEPATNWAPILISTVPSKIRLEQGQVDVDNTMLADEIERVCSVRPAHLKLYGRNETSPPHRTWMTYFTKAPRGGFRAFDESEIARPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG6</accession>
    <name>A0A0B1PBG6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g1693</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000754">
        <property type="protein sequence ID" value="KHJ34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBG6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBG6"/>
    <dbReference type="HOGENOM" id="CLU_017814_6_2_1"/>
    <dbReference type="OMA" id="GFHDTYF"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="140"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="424"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="58836" checksum="0A359132CF01C891" modified="2015-03-04" version="1">MEAYKQKMTEKVPITSSLKEIYAEDTLQVQLERWQSLMQQFNTEYKHQPSFISRSPGRVNIIGEHIDYSLYGVLPMAIEADVILAVSMSSHEASKDYYKIKIANTSPENFPSHVFEFTNDVVEIDPRFHEWTNYFKSGLRGAVEILQRKHGKQFQPRSMDILMDGSVPVGGGLSSSAAFVSASALAVLYANGETSIEKATLTELAIISERAVGVNSGGMDQSASVFSHRGSALYVSFMPTLSTKVVKFPQTNPELNFLIAQSFVKSDKHTTGPVCYNLRVVECSLAAAYLHTCLNKGNKSISLPSDSSPLAISLRSFQEAYFSGSLLSFDDQLSILLKLTKDTLTQKQGYTREEIADVLSCSVEELNKRYMSKFPVQAERFLLRQRAIHVFSEAYRVLEFLSLLQKQEQVSDATNDLSTELFNKNLGNLMNESQDSCRENYSCSCAEIEKLCSIARNAGAYGSRLTGAGWGGCTVHLVPEDKLLEVQIAWDKNYYSNLELDAKQKSNAVVLSKPGGGSIIYVVKDNDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBM6</accession>
    <name>A0A0B1PBM6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBM6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBM6"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="42548" checksum="EDF48A18F881CBED" modified="2015-03-04" version="1">MADILHNAPIVLDNGSGTIRAGFAGDDLPKCFFPSFVGRPKHLRVLAGALEGEVFIGDRAQELRGLLKIRYPLEHGIVTDWDDMERIWEWVYGEGLKTLSEEHPVLLTEPPLNPRSNRDVAAQILFETFNVPALYTSIQAVLSLYASGRTTGIVLDSGDGVSHAVPVYEGFAMPSSIRRIDVAGRDVTEYMQLLLRKSGYVFHTSAEKEVVRLIKEKVSYVAINPKQEEKEWAASMGKIGDGKSIEYTLPDGNNIKIGAERFRAPEILFDPEIIGLEYSGVHQIVVDAINRTDLDLRKPLFANIVLSGGSTLTKGFGDRLLQELKRLAVKDMRIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSIDDWHENPDIIHTKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN7</accession>
    <name>A0A0B1PBN7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000309">
        <property type="protein sequence ID" value="KHJ35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN7"/>
    <dbReference type="HOGENOM" id="CLU_112964_3_1_1"/>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="13086" checksum="4BE21DFC3316BA23" modified="2015-03-04" version="1">MASNNQSFYELYRRSSIGMALTDTLDDLISDRRIEPQLAMKILANFDRSITEVLAEKVKARLTFKGHLDTYRFCDEVWTFLIKDVTFKMENSSQVVQADKVKIVSCNSKRPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU1</accession>
    <name>A0A0B1PBU1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative heat shock protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU1"/>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OMA" id="MSLARQF"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="38"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="181" mass="20460" checksum="E0493CFB32909231" modified="2015-03-04" version="1">MSLFPRSFFSNDQFSFPPIFRLLDEFDHYSRTSDRGLGSFKSFTPKFDIKEHKDSYELQGELPGIDQKDIDIEFTEATTLTIKGRTEHSYSSSAPPRGFIEGEVKNGEEPSKTVIKSEEGKSSQAVEKYWVRERSVGEFSRSFGFPTAIDQDNVKASMKNGILSIIVPKAQKQSSRKITIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU5</accession>
    <name>A0A0B1PBU5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell morphogenesis protein las1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000701">
        <property type="protein sequence ID" value="KHJ34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU5"/>
    <dbReference type="HOGENOM" id="CLU_019519_1_0_1"/>
    <dbReference type="OMA" id="VWMQRGN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="37309" checksum="A6FF1FD673272A65" modified="2015-03-04" version="1">MVQYIITPWRNQAELLKVRSQFYSQHKEEESKSTNDCEDEKQKQIDQEQKKEAVARVRLWMQRGNCPHLIESTAILTSAKLNDLRGGNESFCVRAVYAAAFSRFVTGLLDCHQDKRHKLSMYALAKTIGLPATFVELRHQATHEELPSLIRLQSATQKALQWIWGYYWVNLVEISSILPPTTAITSHSNHNPDSGCKTWLKNLLFQWNGNPHFSAEVALNDAKNLSKKWSNTCIMTALVEIQDSTDDVSILLQIAQLQATILGVRSACALPVQGKISIDDIHRELEVAKYDLSSPVVPISDEIKDGTPQSQKKGWILYEGPWVPKPIGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBV5</accession>
    <name>A0A0B1PBV5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative abc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000693">
        <property type="protein sequence ID" value="KHJ34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBV5"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OMA" id="MVGYCAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001577">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="165"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="516"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="790"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1341" mass="152161" checksum="394D3F7E3AE2EB75" modified="2015-03-04" version="1">MRRKKPIFVCLPITFLSISITQIIIFIDDKPQQTPFLSIIFRLCPALLSLGSIVIILNMPFRDFDKLETEISPIFSIPNSSFRSPEDNLTIWQFMSVSWMAPLISLGRIRQLNDEDVWSLSYEFKHRLLFEKFRKLKGSVLGKLLQANGLDLLIVSVPGVIELTANFLSPVLLGKILQSIESLSSKRTTLIYALLMLLVRWISAQSSVFSLWYSRRVYERSRGEMIIMLYEKTLSRKVRAGSSGVNENPDQSLTSINTISINTRHTPILRRIRNFSARLIGKLCCHRKGYQQEKNSSFASSGKILNLMRFDAYEVSQRFWEFPTIITQPLNLLFSIIMIWRLLGWPCLLGVITVILAQIINALLARILVKWERKRKIATDLKLQYITQFVEVIRHLRYYAWQDVWLKSIMDARQYELGLRIITGLWRIFINFLNTLASGFFPVVAFWAYSVLTRQPLKVNIAFPALQLFSILESSLRELPTLMMALLNASVSLERLNNFMLEPDVQEPPSSIGSEIQLQNTSFAWPGTSEPVLSNLNLKFQPGINMICGKVGAGKSALLLALLGELDQLGGEFLRYKQMIGYCGQMPWLQSMSIRENILFSAPYEQIRYKNVLESCALTQDLINFKYGDLSMVGENGIGLSGGQKARISLARAIYSRANLLLLDDPLSSLDYQTAEFIVQRCLASPLLEGRIIVLVTHRTELCSEMAKQIIFLNSGKACVISKDDLTSKLEFKNEFLKSAKSNQDLNFNLNEDHSLVPNKFLEDEYRAHGGVQSRVYWEYVKAGKLKWWLILVCVLALFRLIEIGETWFLKQWSEAYGKLKEQGMIYFENPFKDLPSPEINLLPWLIGFSLLTIFQAIFYIISQGIMLTIIYKAGKTLFEKVMVKVTYAKFRFYDITPVGRLLNRLTSDINTVDGNISNQFHDVATLFISWLFSMITIGFITPLFLIFALGLSSVFTLIFLHFLPTSQSLRRLEMVLLTPLISNFGAVTDGLTTIRAYCASSRFLDRVITVTDNFQKMDHFYWSLQSWLMYRFDILSALFTFILTIFAIHLEISAGLVAFALTASSRFVTATHSLCRKYGQLQMDFVSVERVVELLNISQEVKGKIIPPASWPRYGSDIVFENVNIQYALHLEMVLSDVSFTIPGGSTTALTGRTGSGKSTLALALLGILPATSGRIIIDGLDLATIDLEILRSRISFLAQDPILFQGTLKLNLDPLSHHSVDECEAVITAISNIQNYSWSLQTLIDTAGGNLSQGQRQLVGLARVLLRRSPIVILDEATASIDTQMAKQIQFLLREWLSQSTILVVAHRPEAVRDANIIIRMANGKILEVKDYRSNLIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD9</accession>
    <name>A0A0B1PCD9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 5-methylcytosine g t mismatch-specific dna glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000564">
        <property type="protein sequence ID" value="KHJ35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD9"/>
    <dbReference type="HOGENOM" id="CLU_008691_0_0_1"/>
    <dbReference type="OMA" id="KNPHTHD"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="774"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="850" mass="94433" checksum="154F0A38759F7B7F" modified="2015-03-04" version="1">MFHRIRHDLVNEKSSEKRDRSKGEKSSEKTQKSKSSKSKLNDNEAEATSLRTKMRKSTKDKSGSQKVKKRVSEPNLAMAEMVVPELSRASSRNSLPYPTFNRQFSKECVHASKNYSNLSMEKPPPTPDLTDFGSDDKMGVKPEEQSQKPPQRGRPPSPPETDIAHGKKTSTRRMSQVKEENEDDKISISNTSLESNSSADGAQSESSAASNVLSHTSKTNKITRETESNTVQNSCNESTNESKVKVDQSQARSDLEAAKKASSINTNSSTDCPKTPIRNNDLSSPGIKDTPSSLTAFEAPDSASEQDELFQKPPRIQKSSSIDAPRVDYLLINGGLRRHITKKLVVPSSATKRSFMPLPTKVEEVFGPCHSLLEHYESVLKKNGSLAVATGYRSVARRLLDRLEVVIGRSLPAEGCSCLMCKHQDLTPEEKPKVLGWGEILEWSSGRKELPQWPTFDFSTLGVKVPDDILGDKLRYQDPLRPSSPVKMDPDIADEFREYYLKQSKKTRLAVDRWLSGCPLAAATPPQEVDDETLSFSILTHLPKEERIIFNALVTGSTTYQPSNLASNFLRKPRSEFLSKTSLSIQRLYRLSTPPRLPEAAIFLLRNPTMHNVLAAVSEINVPEWEILTSGRFDGFLWSGADSDNTSCSYGLTQGFTSSTGPMKWAANSSRGYNSRITSTKNALQSSMKSDSSNSGDPFKPSLVRRPVLNDEETEIAVLAEVEREIYLGMEALEDAFEALHRKAELVRHALRERGASLALALQTHQLAQPVMQNFDVSNPSSSGLGMGYERPTRSESSDIPSDSEWDPGDDFSELAPDDSASNISSSRKRRPKRRNERRAPVLVEEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCF5</accession>
    <name>A0A0B1PCF5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">EV44_g1532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000198">
        <property type="protein sequence ID" value="KHJ35943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCF5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCF5"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="457" mass="50280" checksum="E415958B0D96DEBD" modified="2015-03-04" version="1">MSHVLTSRQAEELHKSIIAYLSSKNLTNSAATLQQELNIGDDFNSTVIKKYEGIIEKKWTGIVRLQKKIMDLEARNAGLQAELNSILPVTLAKRNHDPVNWLPRSPARYTLQSHREPVTCIAFHPVYSSLASGSEDYTIKIWDWELGELERTVKGHTKAVLDVDFGGPRGNTLLASCSSDLTIKIWDPNDEYKNTKTLPGHDHSISAVRFIPSGAAGSPSSSNLLVSASRDKSLRIWDVSTGYCVKTIRGHSSWVRDVSSSYDGKFLLSAGNDQTAKVWDTTSGELKVTLLGHEHVIECCVFAPPTSYGNLASVAGLKKPPHSSSSAEFVATGSRDKCIRIWDTRGSIIMTLKGHDNWVRGLVFHPGGKYLLSVSDDKTLRCWDLSQEGKLVKTIDDVHSHFVSCIRWAPECLKDVPTVNENGVVSGATNKDVSMVTSNIRCVIATGCVDMNVRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCI9</accession>
    <name>A0A0B1PCI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bzip-type transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000761">
        <property type="protein sequence ID" value="KHJ34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCI9"/>
    <dbReference type="HOGENOM" id="CLU_036934_1_1_1"/>
    <dbReference type="OMA" id="TKVRCYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="40550" checksum="DE70D2FABB54F2D4" modified="2015-03-04" version="1">MPSPVNETYPTNQPQNISDIGNNQKQNGRGSLSLNLGFLKNLKEKKLATVDGQPPKKRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKNLEQEVLRLKDSFSKICRDKDAIEEENRRLKAILNQYDIPWTKMCGFEENGRKVSSSNLTARSNSGSNAPRSNFYGISPLNSPLTSNCLSTSPPESVSNFKSIECNQDRKLIDYDQAGIDFVLTLERPCMDHMQFLIERASEPGGEPCGHALMASCPPDSYIDSHSESHFKHCYSGNDSNGQKCWDISKSELANLLDLSKRLNLDGEITPVMAWGMILAHPRFYEMTQQNIDAICQILSGKIKCYGFGAVLEEFEVRDAIESVRFDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCK8</accession>
    <name>A0A0B1PCK8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000031">
        <property type="protein sequence ID" value="KHJ36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCK8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCK8"/>
    <dbReference type="HOGENOM" id="CLU_1385099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="21838" checksum="8B1A1985EDCBBC1B" modified="2015-03-04" version="1">MEEYLNTTKRLNDDLSAKYIKLPKQVVVAWVLSNLTPKYEVIVISIMQSLQINIDSYSVESFFSNLLDESKRQKCNEDNNEQALAVQAKPPSIIGTNSAPTTNQTTQINSDVVMDPNPKADEIGSDSTQTVETSNNVAKSLNATNNNYTRPAIKIAKSQPSIPIDDADDLDELALMVNINNKPKIYKEVLATLLHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD82</accession>
    <name>A0A0B1PD82_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000629">
        <property type="protein sequence ID" value="KHJ34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD82"/>
    <dbReference type="STRING" id="52586.A0A0B1PD82"/>
    <dbReference type="HOGENOM" id="CLU_018084_6_0_1"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="549" mass="59985" checksum="BF22D36826FCC103" modified="2015-03-04" version="1">MADRYIPEHRRTQFKAKNTFKPEELRRRREEQQVEIRKAKREENLAKRRGIATGDGSRPGASLGAEPDSDDDTAPTESQLNEDLPQMVAGVISDQVDLQIHATTKFRKLLSKERNPPIEEVIKTGVVSRFVSFLRSPHTLVQFEACWALTNIASGSSAQTQVVIEAGAVPLFVELLGSPEPDVREQAVWALGNVAGDSPACRDYVLSCGALQPLLNLLGDSRKLSLLRNATWTLSNFCRGKTPQPDWNTILPALPVLAKLVYSLDDEVLIDACWAISYLSDGANEKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPALLSLLSSTKDGIRKEACWTISNITAGNSTQIQAVIDANIIPPLIHLLTNGDLKTRKEACWAISNATSGGLQKPDQIRYLVNQGCIKPLCDLLACPDNKIIQVALDGLENILKVGEMDKDAAGEGQESINQYALFIEECHGMEKIHDCQTNANEEIYMKAYNMIEKYFSDEDEADETSNSQGQGTFGFGNTGSQTGGFNFAPSNGDSMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE72</accession>
    <name>A0A0B1PE72_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000621">
        <property type="protein sequence ID" value="KHJ34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE72"/>
    <dbReference type="STRING" id="52586.A0A0B1PE72"/>
    <dbReference type="HOGENOM" id="CLU_007593_1_1_1"/>
    <dbReference type="OMA" id="HIASEWP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="838" mass="94424" checksum="D28C705920D42977" modified="2015-03-04" version="1">MLFATVPKGAFRKPSSFTFLCVSGLLRDAPCTSGCVELSLALNLEQIKYLKIRRQYLRGITRLSIKINTATNLLVLLFLTSHIYTAALSNLQFASFNDCDDRNDIVTPQKSQKKSPNIKYKSHIDAISAGIYPDLPSQTKVLPQPKHSFNRSLISTSSLSCEEKVDNREGPHKALHVTRNTLSAILYAVEALRAPHPFTPDLLEETASMSTQVNALPSSSRQVSENELSRCKTIPGSSSSVKGPREVMRERAAREARRKAELEHKEALERIRATEEAISLVEKQINDEKLQASDFVQDLDRNQGENNDAITQGLGQVSGQRITSNTREEKKGETLENNAKNTYSHPSNKSAKQGQASSVGDNFRGPKTRLRQPEYQTKLKQTDPIQSHQSAQVGGRSAVLGTRSSFPHAFERWETLSAHWEGLTSFWIRRLEENGREVERDPLLQQLSRQVTDLSAAGANLFHAVVELQRLRASSERKFQRWFFETRTEQERNREIQASIERKFQNEVEARAAAVAQAASEERERLNAEQQLAEAKRELQISKDEAKRAWEELGRREKEERERTTSLREGLPTVIGGVEVVPMITGTPSRSGTTRRTEYISERSDTGRDCNPPNESIVSNTGYSQRSYDVSDSFQDTSNPRRTPVASNLKVANTNLNETSFCEQIPGRESPETSFFKPAKDIPISLQLKSQQPASESLGSSSDQEEDHYEIDSQEDFASKSFGNLSTYQPEADYTRGSEQYDDNEIDRLRQYSQIPEVEYGRGIQVTADYLHNPGSYSVPNIDMDDAADYTDLNQQCYSSGSDWANVPRHHHPTRLSDVMEEDERSRTSASQMSRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEG1</accession>
    <name>A0A0B1PEG1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000567">
        <property type="protein sequence ID" value="KHJ35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEG1"/>
    <dbReference type="STRING" id="52586.A0A0B1PEG1"/>
    <dbReference type="HOGENOM" id="CLU_052691_0_0_1"/>
    <dbReference type="OMA" id="QAIHPTE"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="408" mass="44083" checksum="41FBB47E17E3A038" modified="2015-03-04" version="1">MFENVCTLPLSSQLFAQAVHPTEPILAVGLAGGHVESFRLPVVKSCESSDEDDMNMSIASTGTSTIDTEWRTRRHRGSCRTLIYSVDGEALFSSGTDGLVKVASSHTGRVFAKIAIPQPKTDLSDAPSLLHALSPEVIILATDSAALYVYDLRQSNHIESKPAQKYQPHNDYVTSITSLPPSASSTSGYSKQWISTGGTTLAVTDLRKGVISQSENQEEELLTSIYVGGLPMKPGKSNGEKIIIGESSGFLTIWEKGFWDDQQERINITSRKNDICALESLALVPDEISDGGKNIVVGVESGDVHIVRLGPNKITSTLNHDEIEGVVALDFDIENRLISGGGTYVKVWQEGLTLDSTDSEEEEESSNSDSSDGNGVEKASPLMQKRQKLKTINGNMNAHGIMGFHSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEU9</accession>
    <name>A0A0B1PEU9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fasciclin domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000239">
        <property type="protein sequence ID" value="KHJ35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEU9"/>
    <dbReference type="STRING" id="52586.A0A0B1PEU9"/>
    <dbReference type="HOGENOM" id="CLU_1462382_0_0_1"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="185" mass="21112" checksum="55D4D3CA01D62EC6" modified="2015-03-04" version="1">MEDGIKIMVIDNMTALLSEYLTSREKVDAHNNLKLLSEKLLTFTRERNILNLIHNTTVISNPPPFKSNNLPFRSDNAMSIFPSNRIKPALGQIFAQFTSLHLLFSSLPRTSKDTNLVYQKIQRPNRKSELDLATNVLVIEVLKDNCSQSSVISEGIGWREGRWTAVDLSKDKTDFIRTFHPILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFP5</accession>
    <name>A0A0B1PFP5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000137">
        <property type="protein sequence ID" value="KHJ36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFP5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFP5"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="NNCEHST"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="55519" checksum="1CFC2192F7AD7731" modified="2015-03-04" version="1">MSSDTEIQALPTDMHPTPPPPPAHSAPFPLSPTTPVILTSDNNCEHSTQSTRPILTPAAPSKRVAQSVAEQASQSFEHESDQSYTYLPQELRQIIKQRRRRERAWHVRLSICTSVICNIESTLLVFNDDIEKEEADIIRNYLQQAIARLAASDNALKFPPIPHHTKPPVTKGSTQEKVIPKKKVLFLRLSQEHEWRKLSPAGIREMISKRLHVSPASIGLIKPLRSGFALSPCSNEAREELLQVSGGLFLSGAKLEPANQWVPLLMPTVPRSINTLQGHMEVTKEMLSDEIERVSSVRPEALKFYGNHKPDAPHRTWLALFTKLPKSGFRVFDESGITHVLKKQIAIDFCKRCNGHHSSKFCSRAPSCGNCGSNMHTQDNCKAATRCRNCRGPHRSDSRRCLARPTRHGAPTKEQLRAYRQAGNREFQATIRARVAEEKASAMEVVIETPEVTVVAPEERETSPPISGSLVQVELTESIIDNTQQESDGSSTDSNMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFU0</accession>
    <name>A0A0B1PFU0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000389">
        <property type="protein sequence ID" value="KHJ35449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFU0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFU0"/>
    <dbReference type="HOGENOM" id="CLU_004109_4_0_1"/>
    <dbReference type="OMA" id="MPMNQEY"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000039">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="699"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="900"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="456"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="902" mass="99813" checksum="17DE13B13A2A2762" modified="2015-03-04" version="1">MTTVKTANLPLIPLTRDTVLLPGVVLRIPVASNPSDIPSLLAKIYSRTASKNHAQRLDNIHIACVPLRSPLLTRYGQKMILLDDRTLAHPDKIENFPSYLSSESLFGYGVAAKISGVEGRGTGEFALLVEGIARVKIEKLTRHSPFFEADVIYEYDPVISIEDTALEVLFTQLKQLSRELLTIIRISSLLPRSTSFSSLSPVLSRRLYHYISRKTVTEAGALADFMTNIVEASIEEKLLVLSAVEVKERLEKAIRIVKRQISNIKNNLSISAVSTSNLPANIDLDQFGNQRGRSRLINGLPIPPGLGISEDDQEINDLDELKKKLDEAKLTPEALKITNRELKRLKKMSPAQAEYQVTRNYLENLSEIPWTKMTEDRLGVDTLRNARKQFDDDHYGLEKVKKRLLEYLAVLKLKQSINQDIDIKIKKASEERAHEKLEILKSQRMVDKSPILLLVGPPGVGKTSLAKSVATALGRKFHRISLGGVRDEAEIRGHRRTYVAAMPGLIIQGLKKVGVCNPVFLLDEIDKIGSSNFQGDPSAAMLEVLDPEQNHSFTDHYVNIPVDLSKVLFIATANSLDTISPPLLDRMEMINISGYTTLEKQHIALQHLVPKQIRTNGLENRLIEFNIEVVSKIIESYTRESGVRNLEREIGSVCRAKAVEYSEAKDGGRLNKYVPQLSVKDIEDILGIEKYDEEIAEKSNRPGIVTGLVAYSSGGNGSILFIEIAEMPGNGSVQLTGKLGDVLKESVEVALSWVKAHAFELGLTQDPSENIMKNRSIHVHCPSGAIPKDGPSAGMAHTIALISLFSGTAVPATLAMTGEISLRGRVTAVGGIKEKLIGALRAGVKKVLLPAQNMKDIRDLPQEVKAGLEIIHVRNIWEAMHHVWPQAHWPGEQNIHGIESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG05</accession>
    <name>A0A0B1PG05_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5183</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000262">
        <property type="protein sequence ID" value="KHJ35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG05"/>
    <dbReference type="STRING" id="52586.A0A0B1PG05"/>
    <dbReference type="HOGENOM" id="CLU_010345_1_0_1"/>
    <dbReference type="OMA" id="PEFAPMG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="259"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="711" mass="79260" checksum="282B877D7E515F8E" modified="2015-03-04" version="1">MSSSKRRKLTTPPSNSQLSAFAVRHTLKNKPCDSSTDEHNSGFNSQSVKVQAKGSASIDLIDNSANVDGSLEPKNSISVAGRPSKLFSTFAPCDKNFKESKDGSKFLKIAPGDRLVIVGQYEICVHKGDINLLGATLRHLRWYRVFASPAHSLPVIRCSRESSDLAEISLHPFESGFEELKSLSPLFGSLWDNKSGSDDSRFDNLSPKKNQSTFQILYSSCEKHQKSYFHALVSPPEWNLAISSCIKSSETPPIIFVCGPKSAGKSTFAKLLVNRFLSRSIEKATSISVALLDLDPGQPEYSPPGQLSLTHVKEPNLGPSFSHPVCGRVNECLRSHFIGAISPTLDPEFYITCALSLFSDYRRFLYNNNSKCPLVINTPGWVLGTGLEILIELLENIRPNIVMYMSQEGPPEVVESLKDVDKSINFVSLPSQTSESSSRTAAQLRKMLYISYFHLNSCFKDTLSWNFQPISSFRPWEIRYSGDSPGILGIMCYGEVPSANLLAETLNGSLLSIVVIDEMTVIPGLEKEKGNNKKKMLEDSVHLHKFLESNIIRTPEDLPYFDPKIVTKLRPETSHSIGLALVRGIDISRRRLQVITPISAITLEKLQETEKPIVLVHGKLDTPGWAYTEYLTQRNVLGNNPDIYDESENFLHHDCHENETDTYIALDSGVHEEQSQNIPWIERLQGHQGRSAGSFVWRVRRDLGKLNDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG39</accession>
    <name>A0A0B1PG39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ras gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000240">
        <property type="protein sequence ID" value="KHJ35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG39"/>
    <dbReference type="STRING" id="52586.A0A0B1PG39"/>
    <dbReference type="HOGENOM" id="CLU_1778841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RasGAP protein C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="17472" checksum="783602B2DE10CAA0" modified="2015-03-04" version="1">MSYKDLKRAALENVLKLKQLGRTSGLNFYQDILNAIALDIRTKSWRRVQRHRELEGVRLILVNLNEEAEWLESQRKSYDNYIEQAMITLQKKRKKRFLMPFSTQYNHERELERSGRKAKFGSFKYSTHPLFDKGVLVSWKGYTNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGH2</accession>
    <name>A0A0B1PGH2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000065">
        <property type="protein sequence ID" value="KHJ36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGH2"/>
    <dbReference type="HOGENOM" id="CLU_1070366_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080699" evidence="2">
        <location>
            <begin position="26"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="264" mass="29832" checksum="21A3B0FFFA7CB664" modified="2015-03-04" version="1">MQISRSKTALSVLLVSFLGVRVTGAQTPNPSEFPQLEDGFGETNYGYQCYQRIYLKSSLYAAAKHFCDSVKVHPELKSQGSENAGYQNKLPDVWINKIIRPFAPAQELFIIPVLESGVLFPYTLPPKMRMRQDSNGDTVKVDPGPDRIIVNGNCDILGAFRELDHEANPGEYRMKKCKLLKVPDQISFPPYGTPKPPQRSPDRSPERSPQRSPQRSPQRSPERSPERSLERSHRSPRVSPERVSEKKPEESTEQTPETQISSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHB9</accession>
    <name>A0A0B1PHB9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphal anastamosis-8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000203">
        <property type="protein sequence ID" value="KHJ35929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHB9"/>
    <dbReference type="STRING" id="52586.A0A0B1PHB9"/>
    <dbReference type="HOGENOM" id="CLU_044229_0_0_1"/>
    <dbReference type="OMA" id="WGLVCAI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52597" checksum="5BD852C108284D6F" modified="2015-03-04" version="1">MSCQLANWPYNELIGTQATNIQNYPNTPTHPNHQFKFPSIIKSKSRQPRFTESTTVHSEIETREFGKSSRTDSLRQGFMTPQSNDRVSIAKSLQTPGESLKSDLEVYVIPKDEAPNPLSPTFREEQKLQQCENLTENEQAKDLKVKIRVRMAKFFLRGISFGCSLIVLTMVSMSFSIFYATKNLPPRNHLPAWASGTKIWPQTFILIISCASILLCLIIFWNYFRGGHRKAEKVAVYYTLLAVTLFIFSSIMWGIAAGILQGSRSIGQNKDLWGWSCVENKRRQLFSDKINYALVCRMQNWVLVCCIIEIVLESITILLYAAVFYRYYTKQRLRKSMHIRDRARSDLYSARRQTQSALTSPNVESQSKQTDDKHLPHKIDQSSLRNMVEKGPISAKPFCLQSPPCKASLKTFKTLSSLRPNNKVVQSIDVSSDRHIYEKVPIPSAYPTSPFHQSHPQSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHC5</accession>
    <name>A0A0B1PHC5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000104">
        <property type="protein sequence ID" value="KHJ36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHC5"/>
    <dbReference type="STRING" id="52586.A0A0B1PHC5"/>
    <dbReference type="HOGENOM" id="CLU_009437_2_0_1"/>
    <dbReference type="OMA" id="FPFHSEQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="405"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="778" mass="87976" checksum="34629F9776B98225" modified="2015-03-04" version="1">MPRKILQYDDYGPILREINLSSDNDYLDQLIPILKDAILSNRTSILQQNLSQYASELDSDIENIGLTKHDEFLQSVTQLQNLREGTVALTKEILQLNQSIQESTENLSEKKRALVDTTAIRQNIADASEALKQSLKILHAVNLAHELIRKKQYYGALKALDDLQIEHLIPAIQNKYATQLKLAVLIQDSIPSSRKVISEAVMSDLNTWLYRIRETSQFLGEVAFYHTELRRSRQKERIKTNPLLGKFKLNSAIELVFDETEEFNVLDNEELQVDFTPLFECMHIHEALGQSDKFKSQYAATRKQQKELLLPNSVSLVDDDEKSFSGLLESIAGFAIIEKATLKKAQDLRSPIDVDELWDSMCQTAINLITKALDDVDDAELLLKIKGVVALFIQTMEGWGYSITSLDNFLLTLFKKYATILEKKFSDDFLEIVSNDDYMPMPVNNIDEYDKVVNVSWFKPDKPREELTFPCVFPFSQMYPLCCIDICNFLNQFYFFSDDHFRHPSVIDNTLKASLDLVLSENVCNSLVDRLSVQYLGQIVQILINLEHFETACLELEQLLMAARSNNTSGGPIILNATENFRSNKKTAEKRIFELVNSKIDDLVETAEYDWTAQTLSPEPSNYMQTLTTYLSNIMSSTLLALPPSIKELIYFDALSHATASILSLPLSPQVKAINPNGVAALATDVFYLEQFVSTLPNAILLKDGLDELLQVVALMKSENSDEFYDVAVRNRKFGRVDPIVGANILNKLTHTVQSSKPVDTTGATTLLGGFGSRFMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHJ5</accession>
    <name>A0A0B1PHJ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative translin-associated protein x</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHJ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PHJ5"/>
    <dbReference type="HOGENOM" id="CLU_067225_2_1_1"/>
    <dbReference type="OMA" id="DTCMETC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="274" mass="31175" checksum="78E91D1A4C779CC6" modified="2015-03-04" version="1">MDWRLSSGIVTIKGVKRDRDGSSKIEQTSPFIPMFEVFRDNLDKHYDARERVIKASRDITAVSKKIIFALQRVYNLKDEIPPKIATEIQDKQLIVRNNFESIVPDLLGVNAWRYQHQISPGLQEFVEAVSLEYYLRNQSLISLEEATEILPPEIDLNVHDYILGIFDLVGELMRFAVTSMATTGKLPASKAGEGELRDILADLRQLRCKLEELDISSTSRSWLAKEVPNKMNTMKESIQKVETAVCGLTIRGQERPKGWLPDSSEMKGSAIEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUV9</accession>
    <name>A0A0B1NUV9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative general amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004947">
        <property type="protein sequence ID" value="KHJ30157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUV9"/>
    <dbReference type="STRING" id="52586.A0A0B1NUV9"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OMA" id="NWTIVTI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="43"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="60591" checksum="F3AB43AF3ECC57B0" modified="2015-03-04" version="1">MKVSMEKAGEKELTDGETPTEIALGQDVETTSPGLKRKLKNRHMQMIAIGGSIGAGLFVGSGVALSSGGPGALVVDFIIIGLMLLLTVNALGELACMYPVAGSFYNYSARFIDPGWGFAMGWNYSMNWLIVLPFELTTAGITIAFWTDPNGTGTPSINVGIWITIFLISICVINIFGVKGYGEVEFVLGMVKVIAIIGFIILGIIIDCGGVPTDNRGYIGAKYWHEPGAFRNGFKGFCSVFVTAAFAFGGTEMVGLASAEAANPRKSIPKATKQVFWRIALFYIISLFILGLIVPSDNSSLSKASDGATRFSPFVLSFKLAGIKALPSIFNAVITLSVISVANTCTFGSTRTIQALCASGMGPAKLAEVDDKGRPRVILIIVLLFGCLAYVNEAKNGSIVFTWLLSLSGLSNFFTWGSICYAHIRFRKAWALNGRSIDDLPFASQYGVIGSWIGLGLNILCLIAQFYLALFPIGRNSSARVFFENYLAFPVVIVFFIGYKIYYRQCTIGIDLKSINLDDGRRDINLEELRKELEDERAQRAMSPWWRRIILDNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV28</accession>
    <name>A0A0B1NV28_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ras gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004761">
        <property type="protein sequence ID" value="KHJ30212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV28"/>
    <dbReference type="STRING" id="52586.A0A0B1NV28"/>
    <dbReference type="HOGENOM" id="CLU_000972_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="264"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="906"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1221" mass="138984" checksum="BFC802F623BE5F69" modified="2015-03-04" version="1">MNDTLKPQHLHPLRQTHNLNYSTMTTRKSSRSSIPSSVLSNSASGLDRPPTSIHSPNSSDGSPHRDSGGETRDLSTTLNENRHSSHDSLPIRTCNGMKHSAHSPLQNKTPFISDDMKIHYSRAQSEGLSESPPKHPRTNLNLDKCKSSILSRTNSIYHESDRLHNNLNHLLQSPIRASDLHSFQKSSTSQLRTLSKFTKDITSEDFNTVSPTQKVAGLYGRRKLQRSSTAKGNSTLASNRRLYEWKTRNWMDSQRQLLQAYEYLCHVSEAKEWIERVLQRPIPPIVQLEEALRDGVTLAEIVAALQPEKTIRIFRHPKLQYRHSDNIATFFRFLADVELPDLLRFELTDVYEKKNIPKVIHCIHTLSWHLYRNKIVDFPIGNLVGQLKFEHHELEEMQRGLEKTDLSMPSFENMSTVVGPNSGPKSAFEQVKCEQDLIRSKLEKKLPIIIYLQAQAGGAMNRLQLGEMMHQLSDSEKPLIHLQSIIRGAFARQVINYRTNMRRFATSLQSIARGFLTRQRRAGQISFRKEDEEKIIIRQNLIRAKSVRSKIDRVQRQLVTLKDNTSQLQAQIRDMTSRRVCAKNNQILSDETISIKTMQASAKAGIVRCNLSSLKGQLKGISPAYIKIQSIVQGNQSRQQCQLLIDGMKIAIPLWISFQSIFRGALSQLMHRLLMDKLKAVSPSWAILQSTSRGNRYRLHHQRVIDRLLAAKIQWTNLQSILRANDSRLKYNATINKSKAHTACFSLLQPIIRANVLRCDLNRKMLTLQHEQESISEIQSLIGGMALRREIRAEYEALFALVSHSRNFPSLARGILRRNKILTTGKNPPGNTGKNLGHLLNVSNFDFNEEIEFERLGKTVVRQVRQNEMAEQYIDQLDIRIALLVTNKITLDEVVRCQENFGGHPSNLLVNTTAVSGSQFDLKARNKSSRKKLESYQQLFFTLQTQPHYLARLLTHIRQQGTAEIDCKRIETLVADSLLSPESLVNKMPYGIRFVCQDIFPALFQRFSSEPQQLLPQTVGNRPWKFYLQPARLAPEIIGIFKRQMTLLLKRNLGEIAKVLNQKSFGRLLGGENIHLHPLNAYVEDAIERTTVVFANIISDADADAGGELERSGCKAKFGSFKYSAPPFFDKGVLVSWKGYTDPDRDQANITISCDEVGIFFIEGSKGSIQILGASAQIPMDSLLAAQFANHQFMDLLEGNMRLNVNLFFHLLYNKFCRHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVM1</accession>
    <name>A0A0B1NVM1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005625">
        <property type="protein sequence ID" value="KHJ30018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVM1"/>
    <dbReference type="STRING" id="52586.A0A0B1NVM1"/>
    <dbReference type="HOGENOM" id="CLU_001650_8_0_1"/>
    <dbReference type="OMA" id="RIDPKEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20812" checksum="D676B97A6C373CD4" modified="2015-03-04" version="1">MEMFLGIRITRNRKKKTLWLDQQQYLERTLEKFGIPNAKHRPVSIPLDGYDNLTPANNDEERIDPKEYSMIIGSLMFAMVYTRADIAFALGRLSQYMKEPVKKHGQALKKLMRYLRFTSDYRLCFKPGESVNLVVYSDADWATDKVDRKSISGGVGMLCGAAIFWLSRKQKSVTTSTAEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVT1</accession>
    <name>A0A0B1NVT1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004179">
        <property type="protein sequence ID" value="KHJ30472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVT1"/>
    <dbReference type="HOGENOM" id="CLU_748404_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="370" mass="42296" checksum="4797473318CB012E" modified="2015-03-04" version="1">MTATIESAIKRCEDTATKYETYRIQDEELWEIVYEDLQEAIDSKVIDFNIAKPTSAYKNSLMNLRGILRRKGVYISRKAGKKIMDCFSEFMEPSATGIVPVWPLDSIQALVNFEISSLSEISLGLQYICQRNKIVKGIELKDTIEPILKKGEAIKSTSSNIYSVPEKHPATFAMNDDLTRVIGNISKMYHSNEKKYGGWNDSLDYKMEMYKDICDINQFPVDCRMNGLMLALKELALSEFRNHRNDEGMTFEGMIEHFRICYEGMDFKRSELQAWNSISYKLVREQNPSKLPSECVIILVDLLNEKRRGLDASQKTDDAMHTRLTNACWGIPEFQSALSAPSPHLSTFINQLKMAVSNYQAINVDNKPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW47</accession>
    <name>A0A0B1NW47_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4 10">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4 10"/>
    <dbReference type="EMBL" id="JNVN01004827">
        <property type="protein sequence ID" value="KHJ30193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW47"/>
    <dbReference type="STRING" id="52586.A0A0B1NW47"/>
    <dbReference type="HOGENOM" id="CLU_086710_3_0_1"/>
    <dbReference type="OMA" id="IVRCPRA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="174" mass="19560" checksum="96DAC830D3EEB585" modified="2015-03-04" version="1">MVRIKNRYLLVNIIYPGPELHQKAVKVETPNVLIFNQPTTDDLTSQVLLKSLRSMVLNLFGDYGAGAIADSLSVKYLSPATSTFILRVARAHYKYVWAALTFMTSVPVKDGKKCVFRVIRVSGTIRKSEQELIRRAQEIIDKARRTIINENDSNLLDASFCPDGISDNISDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWF7</accession>
    <name>A0A0B1NWF7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ph domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003730">
        <property type="protein sequence ID" value="KHJ30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWF7"/>
    <dbReference type="STRING" id="52586.A0A0B1NWF7"/>
    <dbReference type="HOGENOM" id="CLU_028348_0_0_1"/>
    <dbReference type="OMA" id="EANIRYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="36180" checksum="8DDE996BF51B43C4" modified="2015-03-04" version="1">MISLNTILKRKMEFHNAIQRASNRKWHRVMVSLQGTALKLYKPSKGKFGMRYAGQNSIPPLLLRSYNLHYAQVGVATDYAKKKHVIRIRAETEQFLLSCDKLETLVNWIQSLSTAIDLATPLDDRDYPEDFCLPRRHRRSRTSPWPSRVEAERNAALSPHIHSRSRILANSSHATRSRSSMRSSSRSEEDQPTLNFSLCSTYLPSIDSTSSTDEISNFSQISKWRPSHQWSPSYDLIYAKRCLAVLTSCMPRKSNTVIVNGEFYVVDWVTGHMCKLNDVMPTYNSYENVLNGSCIREFDVKTPVGLPPEYGDVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWJ3</accession>
    <name>A0A0B1NWJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ectonucleoside triphosphate diphosphohydrolase 7 golgi apyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004529">
        <property type="protein sequence ID" value="KHJ30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1NWJ3"/>
    <dbReference type="HOGENOM" id="CLU_010246_3_0_1"/>
    <dbReference type="OMA" id="TAYEVCF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="174"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="645" mass="72373" checksum="4956451E8961B712" modified="2015-03-04" version="1">MDAGSSGTRVHVYRWLNTSRARYDAKNEIQLNQLPQLHTKPGYSKKIKPGVSSFADRITDIGPEHLQSLLDHALSIVPENQVKDTPFFLMATAGVRLLEATKQKALINEICSYTKTHSDFYLSNCQLHVQVISGETEGLYGWIAANYLLKGFKTLDQETSGQRNHTYGFLDMGGASAQIAFEPNATETEKHANDLNLIRLRTLNGKMSEYKVFTATWLGFGVNQARQRYVKSLMDESYTKDAHELLDPCLPSGLKTSIDGIPVSDTHQGSALVGTGLFDECLRKTYPLLDKDAPCVDQPCLLHGQHVPVIDWNINQFVGVSEYWYTLHAVFETVSKSEKYNFNLYQQLVRDFCSEEWEDIISNVQEKKWGYDFDVKTAQGLCFKASWLMSVLHDGIGVPRNSLSELRPGFNDPTILTLYGNDARSLDPFQPINKIGNMEVSWTVGKMLLYAAGQIPPSDSQGLPVGIGPNNGEPGSFQEAGSNFEVIPEFKDEDSWTEAAEELAEKAHSRSTHGIILFLLFFLIIGYIFRKRDRRLRISRIVRRTRRSSSPPRGNRGFFCASSKYFGPLSVINYDKILDDEEVSADFELGDAEIDDNEHSDSSRRSRIGRTSGRATSKANGIKMDPTNHYFDGSSAGPRVRIEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWT6</accession>
    <name>A0A0B1NWT6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01003622">
        <property type="protein sequence ID" value="KHJ30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWT6"/>
    <dbReference type="STRING" id="52586.A0A0B1NWT6"/>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="36466" checksum="647D2FD4FF93E47B" modified="2015-03-04" version="1">MAASSLTQNSLPGNIQLVIEPHVKYIQSLNSRKDELEYWLTEHLRLNGLYWGLTALHLLQRPDALPRQETISFVLSCLTERGGFSAAPNHDAHLLYTCSAIQILATLDALNELDVKNRGGKLTVGKWIANLQNKETGTWAGDEWGEEDTRFLYAALNALSLLKMLHLVDVDKAVDYIVSCANFDGGYGTAPGAESHSGQIFACLGALSILGRLDTVDKNKLGGWLSERQVDAGGLNGRPEKLEDVCYSWWVGCSLTMIGKIHWIDGKKLAEFILRCQDTESGGFADRPGDMVDVFHTLFGLAGLSLLGYPGLEAVDPVYCMPKKVVDRVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX46</accession>
    <name>A0A0B1NX46_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative calpain-like protease ory</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003431">
        <property type="protein sequence ID" value="KHJ30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX46"/>
    <dbReference type="STRING" id="52586.A0A0B1NX46"/>
    <dbReference type="HOGENOM" id="CLU_006770_1_0_1"/>
    <dbReference type="OMA" id="GDYRRGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="121"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="844" mass="94560" checksum="8966C52501CCF31B" modified="2015-03-04" version="1">MEAENLVSKSLTRDDALKNAIRATELYMSAIEHTVLKSEKNRLQNKCRLLLQKAEEIKGSMTWPLAIQESSGATQESSGATQESSGATQESSGVILKAPVPTRKLSKNEHLILLEGSRLNGFTFPPWTSEPDDDVFENSIEGEKYYTEPVNLRLSDAQRSIFSGWIRLDRDDPNRPGESSVLISTDRATDLVQDIIADCSVVASLCVISSRASKGHGQLTASVLYPKHKTLSLPKISKNGKYICRLQFNGCFRKVTIDNRLPKSNLNRSLHVTDRNDPQNIWPALIEKAYLKVRGGYDFPGSNSGTDLWIISGWIPEQIFLQSDDIQIEQLWYRIFKAFCYGDVMITLGTGKLTEKEENELGLVGHHDYAILDMKEVSSKRLLLIKNPWCDEKLQGLSFELSETAVGTFWMNIESTVQNFEYLYLNWNPGLFRHRQDYHFNWKLPENKNSGSFIHNPQYTIRSSQKDSVWILLSRHFSTDEQNIVDNLQNKISGAVGHISLYVFESSGQKIYTSDYAIHRGAFVDSPQTLARINLSPSIVYTTAIAQHGLPLPQYSFTLSFFSRFPLVIDKVAEPAYYSSQTGAWSLRTAGGNASLPYYHKNPQFSISVTSEADIDLILEAAEHDFAIHIDMVWAGGERVVGINSKDIVGDSGDYRRGCALTSLKNVAAGKYTIVCSTFDVEQTGRFTLHTCSTAPCDVQPIPLEIAGRLTFNLEPLNFPSGVTKMFAKLTISRLTRIRLLAKSLKTSKNSSLSKLRLELKLSIETGQVSKERKVLCVSGDGNFSDVLRGIRLEDLDLTQTMSNAGLWIVVERFSVDHCSDVYINVEVLSDSKVTLGNWRIYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXE9</accession>
    <name>A0A0B1NXE9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003793">
        <property type="protein sequence ID" value="KHJ30658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXE9"/>
    <dbReference type="STRING" id="52586.A0A0B1NXE9"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="80"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="503" mass="56547" checksum="7E4593D4B8E73498" modified="2015-03-04" version="1">MNFTINLIMGASKSFFKILHQVNFTRPLLSFHKFSPMTIFLKQAKKVPYSSISAARLQFGQPVYETHPHLLKPGEVTPGITALEYSNRRSKLCSSLPDNSIVISASSSLKYRSGAVFHEFHQDPNFLYLTGFNEPEAVAVIQKVGSSTDYIFHLFVRPKDQLAEQWSGARSGEQAAIDVFNADKSGDINNLRKLLTPLISQASYVYTDFSKPSKFCQFLERQDKASSEFENLLRHSNVRPLQPLLNNLRMIKSQAEISNMYIAGQASGLAYTNAMRRKWSKEKDLKAFLDYEFQMNGCDKNAYVPVVAGGKNALSIHYVRNDDLLKDGQLILVDAGGEYGGYITDITRSWPVNGKFTEPQRDLYDAVLQVQRNCNSLCRENACLSLDEIHAIAEKGLKENLQQLGFDMSGNAIGILFPHHTGHYIGLDVHDCPGYPRSTKLKAGNCVTIEIGVYVPSDDERWPKHFRDLGIRIEDSLCVQDNTPLVFTTNAVKEVIDIESLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXH7</accession>
    <name>A0A0B1NXH7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gpi anchored cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXH7"/>
    <dbReference type="STRING" id="52586.A0A0B1NXH7"/>
    <dbReference type="HOGENOM" id="CLU_970422_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061537" evidence="2">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="32178" checksum="FD130B28FA0492E5" modified="2015-03-04" version="1">MYSFLLTLTLAGTVVKAYETCHFGLISHGGYSGNVGQLPDGQLKLGGNYSPSKFTINNGGITDSQGRGCILTAEIEQYQCDTGAEAAGGFALGEDGLLSHNGNTEFYACPSSETEYNIYTIPVAGQLKCVSITLKADDCYAPSKPHYGYAPIYSPAPKYPPTPTYGCIPTTVTVTETVYPSKSYGHPYKPYKPYKPYKPHPYKPYKPYKPYKPYKPYKPYKPYKPAPTKGYDHHKHDYYHGPPKHYKPKYGHKYTHKYEAENHPYDVMNEKHSPSEAKNEKADNKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXZ1</accession>
    <name>A0A0B1NXZ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003084">
        <property type="protein sequence ID" value="KHJ31242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXZ1"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="135" mass="15148" checksum="657210293A301CAA" modified="2015-03-04" version="1">MVSFCRERSWKQQLTGSQYWSQQYQPLSYGTRANICKAASKCRNCGGSHRADSCRCLARPTRSSASTKEQLKTYRRMGKREYNVVQRARAAEEKAASSDRIEIDLTSSQASEEIMILDNSQATPVEDSAAVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYA3</accession>
    <name>A0A0B1NYA3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0772</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005608">
        <property type="protein sequence ID" value="KHJ30020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYA3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYA3"/>
    <dbReference type="HOGENOM" id="CLU_154847_2_0_1"/>
    <dbReference type="OMA" id="YRDSCAN"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="86" mass="10079" checksum="0B30BF775084DDFF" modified="2015-03-04" version="1">MAFKDTAIKNSATREEMSEARLPLAYRDSCAGLLIPLNRCRVKEYYLPWKCENERHSYEKCQYDEFLQRVAKMDELRAANGGKRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYD1</accession>
    <name>A0A0B1NYD1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005483">
        <property type="protein sequence ID" value="KHJ30045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYD1"/>
    <dbReference type="HOGENOM" id="CLU_2110752_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="12285" checksum="342841F70BE149DA" modified="2015-03-04" version="1">MSSSFSPPTQNASQLMDTEPGGQSSQYEGQQVIFDKDPITVDSQLTNCGEQFSSTAAKSQAKEEIDERERNEEKIRSGKASSLFTSEEDGGGVGEKTVGITGKANQGVTFGNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYV7</accession>
    <name>A0A0B1NYV7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004752">
        <property type="protein sequence ID" value="KHJ30215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYV7"/>
    <dbReference type="SMR" id="A0A0B1NYV7"/>
    <dbReference type="HOGENOM" id="CLU_1251487_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059237" description="Secreted effector protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25051" checksum="C007EF0F5C187644" modified="2015-03-04" version="1">MKMQTLFFAAAFYLSFVYCQVENPKSSAYLLSKKQLLELARPLAFEYKCMNKHYNEIEIKKAMKKSCMALGATKKKRICKSGICETAITAQRDAEFKNLPPMGYNGQVVLYPILRSSKVYRFENIRDAGHDRIVTTKDCRLLSIVTSVKEPRRSKVIKCNRVEIPNQMFKILPQVNAMKPKTQQTKISVGNMGNMKIQNPKGKGILVDISNEASTSGTKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0F4</accession>
    <name>A0A0B1P0F4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4845</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002628">
        <property type="protein sequence ID" value="KHJ31723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0F4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0F4"/>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="OMA" id="FCWLVIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="246" mass="27625" checksum="09CA0A2CDF5EAEBB" modified="2015-03-04" version="1">MNAIFNTALKQSTSLKRDLVLPLSGQPLTPSFLGQVSASLTAFSRTIDSFSELVGLELNPSKKEKAEERLKNFRAELISFREELKELKLQSEQVQSSINRTELLSRRPHNQNPTVSDNPYSNASTSASIVEDSLWSPKTNSGPLSMGSGDYARENHALREQNFMAQTNSTLDDYLARGQAVLGDLNQQREMLKGTQKKLYSVANTLGISGEAIRMIERRTKQDKWIFYAGAVIFFGFCWAVLHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y6</accession>
    <name>A0A0B1P0Y6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sec14 cytosolic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004131">
        <property type="protein sequence ID" value="KHJ30489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Y6"/>
    <dbReference type="HOGENOM" id="CLU_550038_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="290"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="56837" checksum="25CD4CD710B68D7E" modified="2015-03-04" version="1">MANTGNAKKDTAPTNPRGIPYAPFVDKVEDYVSSRADVEQTLKNFQEMIAKYQYMEANQQRRAAGLKDKMPDIRKTLETVRFLKTRKSDAKPIEATFELNDTLYAKANVPYTEDVYLWLGANVMLSYPINEAEELLISKLSAAELSLENCEEDLDFLREQITTMEVATARVYNWDVTMKRKEQNAQMTSEENSSKFDAKYDNFDYPTTSINPQSGHPGYTTPEQDAKVRQLRNRLLNGGYTERIDTLTLLRFLRARKFDVALAEKMFIETEKWRKEIDLDNLTRNFVYTEKEQVFQYYPKYYHKTDKDGRPLYIEQLGKIDLTAMYKITTPERMLNNLAVEYEKMSDPRLPACSRKSGVLQETCCTIMDLKGVGLSKISSVYAYVRQASTISQNYYPERLGRLYIINAPWGFSGAFSIVKGWLDPVTVEKIHILGSGYQKELLAQVPAENLPKIFGGRCVCAGGCALSDQGPWTDPLWTKPAWWQIPSEEGEKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C1</accession>
    <name>A0A0B1P1C1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mfs multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003261">
        <property type="protein sequence ID" value="KHJ31090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C1"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_2_1"/>
    <dbReference type="OMA" id="CFSIVMS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="548" mass="60405" checksum="266C3D6D4D96A930" modified="2015-03-04" version="1">MMPSDNPPEDQGRIKHDSFDLRINQDLGQKTTYSQSEFEESLKSRLKRLGSQRPEVFSSIWAEIGFIFSISMSQILTEYFVSGFTVVLPLISEELNIPPESSTWPASVFSLAVASFLLIFGRISDIYGGYPVYVAGCLWLAIWSLIGGFSSSDVMLNCCRALQGLGPAAFLPSSVMILGSIYRPGPRKNIIFSIYGACGPIGFFLGILFAGITAEYSVWGWFFWIGAIFSALSALIAYLTIPSDIQAKLSVRDQVEMDWLGSVFIVGGLFLLTFAIIDSSHALKGWRTTYIYSTFITGSFLLLIACYVEARVASQPLLPISFFKEPYMTALFVALILTFGSFGIFLFYSTFYMNYIMSASPFQIIAWYSPMAVGGCIIATFGGLFLHLLPGTVLVTISGVSWIITPLLFAIAPQGANYWSYIFPSMICAPIGIDVTFNVANIFITTSLPKSKQGLAGAIISLLVHLGIAIMLGFADIINTNSAAKLSQRQSYHAVFWFEVASATTALLILTFFVRIKKAESELTFEEKTEFEDVRSSNVVDENIELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q1</accession>
    <name>A0A0B1P1Q1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative pheromone processing endoprotease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003114">
        <property type="protein sequence ID" value="KHJ31220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q1"/>
    <dbReference type="HOGENOM" id="CLU_467844_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="10">
        <location>
            <begin position="181"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="583" mass="63723" checksum="B1BC3534A99F9769" modified="2015-03-04" version="1">MDAPGILIRRAILNAVQNGRGGLGSIYVFASGNGAANEDNCNFDGYTNSIYSITVGAIDRKGLHPYYSEKCSAQLVVTYSSGSGDAIHTTGVGKNQCYSGHGGTSAAAPLAAGIFALVLQVRPDLSWRDMQYLVMETAVPIALDTGEWQATAKGLKFSHIYGYGKIDTWATVQAARSFQKVKPQAWFFAPWVHVKQPIPQGDQGLAASFEVTKDMLQEANLERVEHVTVTMNIKHGKRGDLSVDLISPANLVSHLSVIRHQDFSVDGYNDWTFMSVLHWGESGIGNWTVVVKDTEVNKYNGTFIDWHLKLWGESIDASKATMLPMPSEHDDDDHEKTAIPTTTVTASTTSLSLETSSTAATIAIPTDHPERPQKPPKASGTKNEGAAATATATATASTSAVPTSSTDPTAVPAESEVTWLPSFFPKFGASARSLAWIYGAIGLILAFCGGLAVYLYRARLQRLRNNPRDEWEFDLLEDEEREGLNSGRTRNMGKVGSKRRAGELYDAFAAASEDESDDYFDSDEGGDEREKRLYEDEDEGGRHVIGDDYDEDDCEDDFEDDRDSNRIQDNLSSSIEEKRLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q8</accession>
    <name>A0A0B1P1Q8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative galactosyl transferase gma12 mnn10 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003106">
        <property type="protein sequence ID" value="KHJ31225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q8"/>
    <dbReference type="HOGENOM" id="CLU_021434_0_0_1"/>
    <dbReference type="OMA" id="GEMYHYR"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="465" mass="55056" checksum="A1875506C9019D8F" modified="2015-03-04" version="1">MSSSSSHSPRNGSGWASPGHNAEYSDSTARTSPLDRYYSSSVNEKTTSWEFSKAMKNQSSRYSSFSKKKPGFFTQLYNNFTHNLLRINMQPQLGYVEKEKLARGRWTARGRFKLAQLNSFVRRIRRKTKIRLLIMLGFISLYILFYVTPAHYWWRRTKFLGGGTNFVIILAANQGGGVMEWKGPREWAIERDSVRNKKKYVKRWGYNLEIVDMTTKKRYAHEWREGWEKVDTIRKSMQKYPKAEWFWWLDLNTVIMEPSYSLQSHIFNKLATVTYRDINEYNPLNITHPFPAKYLDEEDLSLIGDGKASSINLIIPQDCSGFNLGSFFIRRSSWSDRLLDIWWDPVGYEQKHMEWEHKEQDVLEHLYQYQPWVRPHTAFIPQRMINSFPTGACSQAGNNSKIHYDQKDRDFVVNMAGCEWGRDCWGEMYNFREISNYLNRTLWERFKEDIVAVLWEKLTGKKIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X8</accession>
    <name>A0A0B1P1X8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative trna (Uracil-5-)-methyltransferase trm9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002217">
        <property type="protein sequence ID" value="KHJ32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1X8"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="55"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="27471" checksum="14D8385C407CE129" modified="2015-03-04" version="1">MGLPEETELLAEKYEEKHVHEVYEQIANHFSATRYKPWPIVEKFLQNLSPGSIGIDVGCGNGKYLSINNNNIFIMGNDRSKNLIQIAKKKIYTSNTIMIADSLYLPYQNERLDFAISIAVIHHLSTRQRRRDAIKNIISCLHQDGQALIFVWALEQKGSRRGWHEGGEQDITVPWVMKSNWVKTDENGTKDETFLRYYHLYKEGELEEDIISVNGKVLDYGYERDNWWAICQRSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P247</accession>
    <name>A0A0B1P247_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002179">
        <property type="protein sequence ID" value="KHJ32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P247"/>
    <dbReference type="HOGENOM" id="CLU_1876977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="159" mass="17571" checksum="E795B2C06880E883" modified="2015-03-04" version="1">MSSDPQSQLSAAFQQSWPNLSSAIEGHQFPDDSNPAPLLTSIASTIDTPEKNMFCSLLLCFDSKFGVLKSQLELKGKKVSKLNSDLGAAQRQVEEIRTALSHAHQEIAVLNQTTNQKTQQIEARLNDINNLNSRLSQVILDRSTDNDKISFLNDKISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P282</accession>
    <name>A0A0B1P282_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002889">
        <property type="protein sequence ID" value="KHJ31440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P282"/>
    <dbReference type="HOGENOM" id="CLU_1082563_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="30852" checksum="624C53388F0B20C7" modified="2015-03-04" version="1">MIHQRRYGTHYFANTQKQVQTPGKSPEECFNYLKVLRRRFLQQRPEKKDSLRNEDLFGYLLDGLVEEEWTLTKNTLDAQPNLETDDKLEILQQLWDSTPSLKRNEEDGFIAKSRWPNSRFQKQRQRDLPASPEDRSWPKENNQPSRNRVRNYRCYVCKSEEHCVDICQYKERAYEWAFQLRLKDEKIFDKSSKHSSSRKETDRVANNRRTHLNRQKEKKTAYVAQDIDSEVYESYSKIESDDEDDDNDVVVVVEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N4</accession>
    <name>A0A0B1P2N4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative msc1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002748">
        <property type="protein sequence ID" value="KHJ31595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N4"/>
    <dbReference type="SMR" id="A0A0B1P2N4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2N4"/>
    <dbReference type="HOGENOM" id="CLU_022672_1_0_1"/>
    <dbReference type="OMA" id="WTFDTWN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079679" evidence="1">
        <location>
            <begin position="20"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="566" mass="62747" checksum="ADEB56995B5B9D1E" modified="2015-03-04" version="1">MRVFLQLAILGLATEFSFANNWFTRAVYNKWHETELERWLSDHNIPYPSSADRKDLEKIISENWDSKINQPYTDWDVNQLSSYLKEKGVEIKDSTAESKDGLISRVKNIWSEKVDQSENSWSDIKDWIFDGWSDSALKAFADKHGIPVPQTQTQKRETVLQALRSNYDTVASKLGQSVSYPGNWLYDSWSDSDLKEWLDSHGIPAPQTSTRDKLIASVRRNSRIASLKARNAQASATKSAASVSETLSDKILESWSDSKLKEILDKNGVNVPQGSKTSELLALARKYRAKLLDDTAGSTAKNVVGKLGDTFGAATSSVEDQYSKATDDAQLKAQTAFDTAIGTWSDSRLKAYLDSRGVPVPQGGKRDEILAAVRLNRYKAANGWSAWTFDTWSTENLKKFLASSGNKASEQIGNTVGASRDQLLSAAQDVYTTASRSSGSTFASITSYLSLQTDTAKDSVFDTWSESELKNYLDSYGVPVPQGSKKNALIAWARNQRNYFQYGTTTPQGTLWVKLQNGASWAWDQVSAGRKQAEIAADTVKEKATYASNRADEAAQVAGDKIKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2R0</accession>
    <name>A0A0B1P2R0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative bhlh family transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001979">
        <property type="protein sequence ID" value="KHJ32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="RILMMEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000978">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="389"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="463" mass="51076" checksum="2FD0EFED85A98FDD" modified="2015-03-04" version="1">MLVVRHASMGSSKPPNQELLFGYTFDDSGTSHPYPSPTAPAPGPSLLDDNESRFLDNFFDGVSSDQFNYDVFNTDDANNLGIGWDDIPPNPMGNTSSYVQHPQTGSHGGIVGLDFPQVNTQMVPNPAILSTTANEVLQAANLLQNGLPGRNYVMGEEGYFRGREEQLFPTDRSIGTGLGIMSRPLAMLQPVLEPRSSLECYSNEPHPTNLIFDGQSAALTRNRGVNLRADIRWGSDAAFATPQGFTAPSSRESVSAAERYHLQTIETAFSLSSNLDSAEERRCPSSDLRYGSISHQRVNSKGQNCIESDQSQGLSTNKGRNIEGQEEEEDDDFLSSSLQTSRVGSRKRKFGISESTDSSILEFESSHRRKRSTTSAGVRSTRENLTEEQKRENHIRSEQKRRTLIREGFEDLNELVPGLQGGGYSKSAVLAQAADWLENLIRGNETLRTRILMMEGQVTKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2R9</accession>
    <name>A0A0B1P2R9_UNCNE</name>
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        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01003122">
        <property type="protein sequence ID" value="KHJ31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1P2R9"/>
    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="OMA" id="KKWIMRA"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
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        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
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        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109915" checksum="257D6823FC87A8B6" modified="2015-03-04" version="1">MNFVQILPNSYTEKKLDDMETATIEEQKRWIIKAANSETTSRFFKNWLKNSWAAFLDQLRNAEAPDIIIVLLGYISMHLTFFSLMVSMRKMGSNFWLFGMTLLSSTFAFLFGLIVTTKMGIALDMIILSEGLPFLVVTIGFDKSIILTKAVLSAALRNRRPAPGLLGNNRQPAFESKHVVSSTTIPYAVQLAIEEKGYMIVRDYAIEICILIIGAISGVQGGLQQFCFLAAWILVFDCILLFTFYTAILSIKLEINRINRHVALRQALEDDGINKIVAENVAESEEWPKPSLVGNDMTNIFGRNINNNSVPTFKILMVSGFIVINVFNICTIPFLGGSIDHELSSSIGPMRNSIISGNLSPSIDPFAFTSSGLNSMLESSKSQGRTVVVDIFAPINYELENSSETFGSQSRNVDYPLNLNGKYVNLNEYGISGRVITSFLSSLEDPTLSKWIMLALALSIAINAYLFNAARWSIRHPLHVSSDQNFDPSTIKYHQNEASDVISSSPQKKSQFMETNQPYDNTLQTPINIDDEEEGLEICLSKSKSPSKRTQAQLEMMLKENQASELDDQELIELSLQGKIPGYALEKKLKDTTRAVKIRRAVISRTLTTSQTTGLLEYSKLPYKNYDWDRVLGACCENVIGYMPLPLGVAGPIIIDSQSYFIPMATTEGVLVASTSRGAKAINAGGGAVTVITGDGMTRGPCVSFETLERAGAAKVWLDSEIGQKIITKAFNSTSRFARLQSIKTALAGTYLYPRFKTTTGDAMGMNMISKGVEHALNVMATEAGFEDMQIISVSGNFCTDKKPAAINWIDGRGKSVVAEAIIPKDIVKSVLKSTVDAMVELNISKNLVGSAMAGSIGGFNAHAANIVTAIFLATGQDPAQNVESSNCITLMRNLGGNLQISVSMPSIEVGTLGGGTILEPQGAMLDMLGVRGSHPTHPGENARRLARIIAASVLSGELSLCSALAAGHLVKSHMAHNRSAPITRSNTPAQISTHPSMISTNSMREKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V1</accession>
    <name>A0A0B1P2V1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001950">
        <property type="protein sequence ID" value="KHJ32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2V1"/>
    <dbReference type="HOGENOM" id="CLU_009923_1_1_1"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="60924" checksum="6462F032A5CE22AD" modified="2015-03-04" version="1">MKLTNSNDVLVYTVAGACTARPLPEWLARKRKRSLKNDPEYANRVELLQDFEFDEASICVRVSEDGEWIMSTGTYKPQIHTHYLPHLSLSFARHTTSLNQSFVLLSSDYSKSVHLQTNRTLEFHTPGGCHYQTRLPRYGRDLQYTRHNTEILVPAVGVNADGSGEVYRLNLELGRFMKSYQINVGNENLTEKEGNGLQGGIDAGSVNVAAIAEESHNLLAFGTSIGTVEFWDPRSKERVGILSQNNEEITALNFNASGLSIVTGSSKGIIQIFDLRRPTPILTKDQGYGYSIKTLLHLTTSSGEKKILSADQRVIKLWDEIDGKPWTSIEPTVDINSVAWCKSSGMLVTANEGRQQHAFLIPQLGPAPRWCSFLDNMVEEMAEEIKVETYDNYKFLTLPDLKKLNLAHLIGTTNLLRPYMHGYFVSSRLYEEAQLITNPYLWEDERNKKIQEKIEKERASRIRNVKKVKVNQKLVDKILKRQERREKIDLEDGILGDSRFGKLFEDEEFEVDEKSREFQALNPSTKINNNSNEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P361</accession>
    <name>A0A0B1P361_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001608">
        <property type="protein sequence ID" value="KHJ33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P361"/>
    <dbReference type="HOGENOM" id="CLU_2401312_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="93" mass="10286" checksum="C93F4435CFB05825" modified="2015-03-04" version="1">MFQNIVAALADALKETVLSQHLQRIFREFITDLNAVARQHFECHVRGTSRPHIFHSVTSTINPSATTPQSKNKTSTKIGIATANNTTTKAQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P384</accession>
    <name>A0A0B1P384_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001849">
        <property type="protein sequence ID" value="KHJ32733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P384"/>
    <dbReference type="STRING" id="52586.A0A0B1P384"/>
    <dbReference type="HOGENOM" id="CLU_001265_25_1_1"/>
    <dbReference type="OMA" id="GVFVYYM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="111"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="661" mass="73055" checksum="D61BF5E5BAF80F92" modified="2015-03-04" version="1">MVPNKDFVENSLNSYDTEDLSQIALLRSSFEEAEEGEWSQRYHRRPRQSARALREIVGAVKTQNIIELKDIEIPNLAPRTISRTEHFLAAMISGGERQMWGLNGKPLVYFTSIFVSLGVFLFGYDQGVMSGIITGPYFKDYFNQPTRAEVGTMVAILEIGAFFSSIVVGKVGDIIGRRKTILYGSIIFFTGGTIQTAATGIPMMLLGRIIAGIGVGMLSTIVPVYQSEISPPHNRGKLACIEFTGNITGYTTSVWVDYFCSFIDNDYSWRIPLMMQCVMGALLGFGSLLIVESPRWLLDNDHDEEGIVVIANLYGGGDIHNAKARDEYREIKMSVLLQRQEGEKTYMEMFRRYRTRVFIAMSAQAFAQLNGINVISYYAPYVFESAGWVGRQAILMTGINGITYFLSTIPPWYLVDHWGRRFILLGGAIAMTLALCSMSYFLYLDIQLTPTLVVASVMIYNAAFGYSWGPIPWLYPPEILPLSIRSKGASLSTATNWACNWIVGELTPVLQELITWRLYLVHAFSCAASFVVVYFVYPETAGMRLEDMGALFGDATVTANTPAQLAETGSLLGACSPVPSMDLRRGMYSGGTPRLGPSSAIAGLDIDPPHVNIQNGKPRYTEDNDGLSEGLGGWISRVVGRGEGSIRSGKSGRYNALDQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3B9</accession>
    <name>A0A0B1P3B9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002893">
        <property type="protein sequence ID" value="KHJ31436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3B9"/>
    <dbReference type="HOGENOM" id="CLU_1518974_0_0_1"/>
    <dbReference type="OMA" id="IHNASIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20215" checksum="3C93DCC697C19921" modified="2015-03-04" version="1">MDDICLIAASKSIRKNIKILGREAAQLYVLEDQNAINFNLAKTELVHFSRSQEAKSRKLTLLNGAVILPNQLVRWLGIWFDPMLLFSQQITIRLTQATKAFYRLVRLATTQRGLSPQALRQIYLTCVVSVSDYGPVIWWKGQNSIVDHLQKLQSREIRKILGVFCTSPFSQQNLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L2</accession>
    <name>A0A0B1P3L2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001782">
        <property type="protein sequence ID" value="KHJ32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L2"/>
    <dbReference type="HOGENOM" id="CLU_1490075_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="181" mass="20644" checksum="579DDC1A9EF5D53D" modified="2015-03-04" version="1">MNEGCQAYLRWWISGGELTFPSVKAMLHLLKVVFDDPNRVQHAKLRLYSNKHPSNSFPWISEIKVDAAISGYDKFAEPLRDTIIRNLSMKLKQAFIYKKGIENLDLDSAMARLQDTHNKKRPNAAPASKFRFRAPTTPDVNNTQPNEHLTTTQGGDSMDLSASYSRPRGPFSEEEKGRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P401</accession>
    <name>A0A0B1P401_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative upf0664 stress-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P401"/>
    <dbReference type="STRING" id="52586.A0A0B1P401"/>
    <dbReference type="HOGENOM" id="CLU_066296_1_0_1"/>
    <dbReference type="OMA" id="SNRLEDH"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="27850" checksum="65863A97AFE7BBE7" modified="2015-03-04" version="1">MSLNWVMTSSNGQDFLKLPNERILFTSHPRTSLEIITPNNIVGTPPFSPKSDGGIAYITNQRIVYLPSNPKPALKSFSCPILNIQDTYIHSPFFGANSWFGTCKPVPGGGIPTAFSVVEIKFVFRDGGAFNFRSCFEEIKERLHQAYSVAQETTSHEIDFTDIDIEPLPAYRSARELREESEIERSPAYQKYETDSSNEENGTIKNEQIRTIPAEAPPSYEEFQAQVNHADREQDIRQVVDITPVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A7</accession>
    <name>A0A0B1P4A7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="JNVN01002840">
        <property type="protein sequence ID" value="KHJ31504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4A7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4A7"/>
    <dbReference type="HOGENOM" id="CLU_031312_1_1_1"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="45025" checksum="FCCD883199F6006B" modified="2015-03-04" version="1">MAAPQIPNLLSLRGKPNSRRLDRNCETKLCTATTQQRRDIDIQGTDADAAVSRLSAVSMGYLNDKYASLFVKGPLVRRLPIINRGQSCIFAVLADIIAGTYVRTIALDTLIDSFLISNDYPKDRTLKQIISLGSGTDTRYFRFRDSKKYKRFVYHEFDFPEVSFAKRRTILSQPELHRNSDSEYLWSAAEPLDKDSELKEWGFIRREENIEEVAYCFHPIDLRQITKKENLLSFFGLRADLPTLILSECCLCYMDVIESSAIIKWFTEKIPSIGIILYEPIGSDDSFGKMMISNLAARNIVMPSLSQFKTLSDQRKRLSEFGFNRTSPKTGCNAKDINETWEDWIPAAEKARVNNLEGLDEVEEWQMLAKHYAIVWGWRSISDEWNHWTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4F6</accession>
    <name>A0A0B1P4F6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative abc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002241">
        <property type="protein sequence ID" value="KHJ32210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4F6"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OMA" id="QVTDAWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1102"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="154"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="570"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="853"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1165"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1413" mass="159155" checksum="C09088B52A5C5027" modified="2015-03-04" version="1">MGMDSNSEVMNINGHFKKNKKPGKETSSTSRAEFNTTRILEFDSSEPPQGEKSWLYKLNPFRQGSVPPVPKEKLVTKEYNAGFISRLYFHWMTPLMAVGYKRQLHENDIWSINPRWETGIITSKLQANFKKQIACGGKNPLIFALYETFKRQFWISGFCQLSASIIQATCPFLLRYLIRFAQLAYNAKMGGPPPPSIGIGLGLVFGLTLLQMVQSLQINHSVYRGMVIGGAARASLISLIFTKAMNISSKAKAGDGSICGLSNVRNSTEHLETQLDLEGKIKPKKKKSNDGIGWSNGRVMNLMSVDTHRVDQASALFHLVWTSPIACIYTLALLTINMTYSALAGFGLLILGILFMTQVTKRLFSRRKNISNITDQRISLTLEIMQAIRFVKLFGWESAFLIKLQQIREKEIHAIQILLAIRNVMNTISISLPIFSSMLTFLTYSLTNHNLEPAIVFSSLALFNSLRIPLNLLPLVISQTTDAWSSISRIQEFLLSEDLKNILQVDLEADVAVEIRNADFTWERTPIRETPSKNTQMKDSRTKFHYMEVAKINTLQNKDERLPNPTSESYNNKDDNNNISKPPFQLQDINLVIGRNELVAVIGGVGCGKSSLLAAIAGDMRKTNGELKLGASRAFCSQSAWIQNTTVRENILFGKEMQIDWYNQVIEACNLNPDLETFPFGDMTEIGERGVTISGGQKQRINIARAIYFDSKIILMDDPLSAVDAHVGRQIFDHAILKLMKDRSRILATHQLWVLDKCDRIVLMKEGHIQAVDTYKNLMRNNADFQRLLDSTVTEKHNSRPTDHPSQDGVHVPLNSKLKGSTLMQIEEKAIGKVPWNIYLDYIRASGSITNAFIALVFLIASQCTNIITSLWVAWWSANYFGYSRRSYIAIYVALGVSQALLSFAFSLVVTLISTISSKKIMNRAITRVLRAPMSFFDTTPLGRITNRFSRDVDIMDNELSEAIRVYCMTLVMILTVFCLIIAYFPFFIIALIPLSIFFLYSSSYYRASGRQLKRIESILRSHVFAKFSEGLSGTACIRAYGVQNFYISKIQATLDDMNSAYFLTFANQRWSSIRIDIIAILLVFVTGILAITSRFDVRPSIVGLVLSYILSIVQMMQYLIRQLAEVENGMNAMERLHYYGLSLEEEAPRHTIEIRKTWPETGEIVFKNVFMRYRDNLPLVLNGFSLHVKSGERLGVVGRTGAGKSSIMMTLFRLVELSAGSIVIDNIDISTIGLHDLRSRLAIIPQDPSLFKGTIRSNLDPFSEFIDMELWSALYQSGLVPSSTQPNSKKNDLHLDSVVDDEGSNFSLGQRQLMALARALVRKSRIVICDEATSSVDMETDIKIQQTMITAFKGITLLCIAHRLKTIINYDRICVLERGNIIELDAPKALWNKGGTFRSMCDKSGISEEDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4H8</accession>
    <name>A0A0B1P4H8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001585">
        <property type="protein sequence ID" value="KHJ33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4H8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4H8"/>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="441"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="649" mass="74124" checksum="3518532A4415FA2E" modified="2015-03-04" version="1">MSEEKTKGISLRTKRKGRSAISRPKQISGPVLPVDTLQNDIKLSQESPPPQRLQVGGKTSNLVKQRYSTRFNNLPADFDPTKPPVPSVPSIPVQFTPKEYNLKKNAGRDKKFDLDITALQDPNLRPDIFIASLLDDASEQDINDYQRSLQNLRDRASKDLQQNFYQNRRQLIKISKEAEKLKEEMRALKNLMSDLKINTTALRAASSQNNTDFEGFVSGMSKREKRSSVADRTAIWNSQLQALWKMIEGSQKFLPAASDRHPVQDAGLWIELDNATWKPRRAMRIILLNDHLLTAVRKKRRLEGNGTDQYKAATKLVADRCWPLLDIEIVDLAGINDSVAGKNKVTDAIMIRGIGHETFTYRTEKSSGIEKQSLIINFKKQVEELRKGLRSEMETSNKSKETLNYFASRDPGLLKKADLLETLSDVKDMLIEIDGKQQNLRWIESQVDSLDIDIALQRFDAAVVLIEKFNSLAKSLKSNVVAQEFISFKTSERATKLAGLITKELVENHNLPKKVKCNVNWLTRLGFEDRAREVYLETRSDIIRKRSRQCIFEGDLHRHTWEVSFIYFTIIRNTVITFQMCFPSSLMSACVKWVKEEVEGFNTILLRQLSSTKRGSSTWDLCLNQAREHANILFEVGLDFNDLLGQDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R2</accession>
    <name>A0A0B1P4R2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001540">
        <property type="protein sequence ID" value="KHJ33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R2"/>
    <dbReference type="HOGENOM" id="CLU_002055_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="759" mass="87546" checksum="6B86240AE60B8745" modified="2015-03-04" version="1">MGSNTESKGMDEKTLSYETSKLRDYSRGIDLLKDTDEDVLKFIGNRVEEYALHEHQGDDLWWYFYDDFKEFTKAESFIRAGKELPRRLRDVLRKRGGYIPKDKKSIAGNLVALLKLDEPPVWPATDKEYDRVMGLTRPYFNLGTQSRLHGKVIETKEHQDIESKDRQNIGQDLKGHSNQPPKIDCSLNQYSNNSEKDLSTEYDQYRILNYKPHGFSQQLATLAKIYDNRSKYSGIGDTFDYKFDILLRQCENADIPKDALVNAFSIMLKDDALDFYYNFYCDGQKRSLEQMCKEFKDKFEGIEHKRSLLKNWNNLTFETVVNDKDNVGKSTAECLQIFTRLLTIMQHGLDINLRNDAFIHNKLVTACEKQPAFKNVCERPAATLFGLVNDLRSAAEFHDRTSKLTQTENTFLIDRRYHQGQRNFQSNQYRRSGQPILRNTLLSSRNTISDKNKCLICKKEGCWSTMHSKKERDEAFNNIKLKMKNKIDKNFSQYCQEIEGMPPTDKNFSDLDLDNNSDDIDNCMENFIFDTALLSIDQNEELSHTFTTEFNDELNGAKIAVLLANQATEHAILANSKNCNLKNFDSRYGPSQFQGIVIDTGAANYSTGGYNQWTALQKHQKVPIDKSTKSSVNVQFGIGATSSIGSIDMITPIGTIKFHIVEANTPFLLCLKDMDSLGVFYNNLTNRIQRGTKSFPIIRRYGHAFLCWGDIFTQYITQSSYLSENELRQLHRRFGHPSVRRFVNLMTQSDHKIDQKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R3</accession>
    <name>A0A0B1P4R3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01002206">
        <property type="protein sequence ID" value="KHJ32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P4R3"/>
    <dbReference type="HOGENOM" id="CLU_001324_14_3_1"/>
    <dbReference type="OMA" id="KPCYAMT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="446" mass="50656" checksum="7DAEED5BCB0EE525" modified="2015-03-04" version="1">MLKDVRPINLGKIKDFLTDDCLHRLSLNRDTINPPSSNWTEEQCRYDYGLWLLGDILRDLNRDWASAYITGPEHTWKNRESEPNPLVMEALNIDRVEEERQLNLALTTFSSGQRFAFDKITTIIDNNVKPNTFFLQGPAGTGKTFLYKTLCNKYRWEGKVVLCVASSGIAALLLPKGRTSHSLFIIPINSNEETQCRITGNSDLAGLLRRTLIIWDEVTLQSSHDFAATTDDRNVFREYIYPQDQLSAGDVSIFNDQAILTSQNDEGTSFNNTIAELRPTESHEYFAQDKVQNEEARHISDYPAEFLHTHGGSGLPLGGLTLQVGMPVMLLRNLYPKVGLYNGTRLIITRLFDHGVRERVTSTCPALHGREQYIHRIVMTTDENMYFTLSRRQLPLRPCFSMVINKSQGQTLQRVGVDLSTPVFSHGQLYVALSRVTDIDNQILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P551</accession>
    <name>A0A0B1P551_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative n-acetyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002360">
        <property type="protein sequence ID" value="KHJ32076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P551"/>
    <dbReference type="STRING" id="52586.A0A0B1P551"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="190" mass="21833" checksum="D7B7336DFDAC264A" modified="2015-03-04" version="1">MTSLRPFHATDVFKFNATNLDPLTETYDLNFYFSYLAHWPHLFTVATSPDETISAYIMGKLESSPVYAINSPHYLPFHAHITALTVAPHSRRLGLARTLSSSLESAGDTYDAWFVDLFVRKSNIIAQTLYRGLGYSIFRTVKEYYHDDVMGDSQQGEDAYDMRKPLKRDKDKKHIRKDGEKFLVVPADVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P568</accession>
    <name>A0A0B1P568_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001229">
        <property type="protein sequence ID" value="KHJ33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P568"/>
    <dbReference type="STRING" id="52586.A0A0B1P568"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="35012" checksum="19ACA85CE86FF5EA" modified="2015-03-04" version="1">MARRKLGKHKSTKAAPTEKRLFVRLPLKHEWRKLSPAGIREVIVNKLAISPSLFGKIKPVDSGFALSPCRTEARENILNAGNGLFLSGAKLEPATNSIPVILPTVPLSIQKVQGQIEVSSSMLIEEIERASSIQLAHVKLFVRNKAEAPHRTWMAYFSKTPRIGFRVFDESGIARPFKKQQSIEFCKRYNGNHLTKNCTRVPPCGNCGFTNHSEELCMAATKCRNCGGPHRSDSRRCLARPTRLGAPTKEQMKTFRQVGEREYQAVLRAKVAEESANSAENINIDLTCSQDPEVDGDIKNIPASPIENSTGDAIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A2</accession>
    <name>A0A0B1P5A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002325">
        <property type="protein sequence ID" value="KHJ32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A2"/>
    <dbReference type="HOGENOM" id="CLU_2098639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="116" mass="13376" checksum="0149D99BD254DFDE" modified="2015-03-04" version="1">MEPTQVLDNISRRPGHPGRLSAVKYMERLKKAQDFAQPAMASVQQRYEDNANKFRLQPEVFKVGDKVWLDVKNIKTPQLSKKLAWQHAKYEITAIPDALTVELNVPGNIHKRFHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A9</accession>
    <name>A0A0B1P5A9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative nadh-ubiquinone oxidoreductase kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001413">
        <property type="protein sequence ID" value="KHJ33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5A9"/>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6 10" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="9">
        <location>
            <begin position="108"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="281" mass="32355" checksum="9DC171E46173CDB1" modified="2015-03-04" version="1">MASRVPNRRAISPLIKSFRLDQSVRNATISRGFVTTRPKHVVITGNTPNMRHAQRNPDSTQGLCVPPINPSEKYASKAEHIHRYGSWLMSCLPKYIQQFSVWKDELVVYISPSGVIPVFSFLKYNTAAEFTQVTDITAVDFPNRNQRFEVVYNLLSVRYNSRIRVKTYADELSPVPSITSLYDGANWYEREVFDLFGVFFVGHPDLRRIMTDYGFDGHPLRKDFPLTGYTEIRYDEEKKRIVVEPLELTQAFRNFEGGSSAWEQVGPGIDMKPDSFKQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5B4</accession>
    <name>A0A0B1P5B4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative family transcriptional regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001412">
        <property type="protein sequence ID" value="KHJ33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5B4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5B4"/>
    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OMA" id="YDRINRT"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="18483" checksum="7FC37E7E181B1BB1" modified="2015-03-04" version="1">MPSLYQISVPVYIKNLKSLSKILEKGSAHEAVSNDQLINTRLAADMENFTFQIQRVSDAAKFLAERVGKIAPVTLEDNEKTYEELQERIKKTIEILESVKESDFAGEEDEVSFSLKGHDFKFSSKNYVLEWATPNFYFHFVTAYALLRKEGVNIGKKDYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5E1</accession>
    <name>A0A0B1P5E1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative atp binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002526">
        <property type="protein sequence ID" value="KHJ31864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5E1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5E1"/>
    <dbReference type="HOGENOM" id="CLU_001066_2_1_1"/>
    <dbReference type="OMA" id="EWIMVEA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="147"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="343"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="658"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="733"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="848"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1270" mass="145621" checksum="A1AD2493A08A9DDB" modified="2015-03-04" version="1">MHPQAGTKRGGAFPDAIEETNVITEKIPHNIPTNQAYKILKEHYHVKEHIYGLSKTESWRNLPDIPCSEEIMGNGNLSGVILQPEDWNEYQNDPIYYPEIPQNVVNCPWKSTKEYIAAHYKILREDAIASLRNVVQTFKRKPNMLEEDQINIYTEVTITGWFLTRQGPACRVEFCVDRSEKRVRWEQSRRLLQGSIVALSNSNDLFKTDCKVAIVAGRAIEGGLDQSPPTIDLFFGDSEKIEIDPHEKYVMLEARDGYFEASRHMLTAMQKLATEKFALQNHIVFLDQNVKAPQYLIDQPYLDLTWLKDYSSKSTGKTSQNRTCDLKNVNILQDFSQNFDFGMDESQIRALYAMITRSVAIVQGPPGTGKTYVSVSALRLMINNLRLGNPPIIVSAQTNHALDQLLCHIMKFEPNIARLGGQFSRTNTKIRERTLHELHSSNQNRGRDGEMGRCRKELSRLVEKIKDILAPLLTDNLLTLDLLIEYKIINEKQRQSFSAVNWVGDETSENEIASWLGSDQIMFIKRASPVNLGLPLEEDISEYEQRKDMIDIDEDPDDPLDVNSGNLIGTWIPYLREYTGRHVGTIDSKKWKKRLSKIKDIYEIHENERGAAYRYFEIRVNSCILKTFKSILREYQKLVHEFQIARALRDLDLLSHTGIKVIGCTTSGLAKYRGLLSALQPRVLLIEEAAETLEGKVMAGTPESIQQIIMVGDHQQLQASCTIRSLEEEPYNMKVSMFERLINNNLPYIVLNRQRRMITEIRELLCIKPRPFYENLYDHESVLDRDIARPAVPGMGGKDTYFFHHNWPEARNLEGSCYNEDEAEMVVSFFNYLYLNKLDPLKITILTVIDGYQGEENDVILLSLVRSNTQQSIGFLGNKNRLVVALSRARRGLYLFGNSVTLTTGESEDPNIGRELLWLPLICYMGSKRRYNLDDGLPITCSRHQNITVVNEAEDLEKLTGGCNLKCDRLLPCHHKCPLKCHAFDHENLSVCKEPCPITLACGHLCSRKCSVTCYCKKCDQRETGSVKLENLNIKSKLPRTTTERLDFFTNQGDYLNKSIVDSVISLNKTNCKLKFPYGHDEAGQVQRSESYYKKLGQRKLEWTKWDARKADQIAIEQERGREAQKNKNYPIEYHDSHKHITVRNGQRVTGKISQTIIEATNSTSKHLKKTTNDDLKPTRKNLYSEDKLSAKNWNRNFPTEWNSPTTPSKNFIEDDQLLIDLSDHGHHFLDDNPEKKSSAHKTGPKKLRDLSLLLEKSNIDNKEPSHLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R0</accession>
    <name>A0A0B1P5R0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5R0"/>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OMA" id="NLHRHAD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="581" mass="63219" checksum="5C004528D8F59521" modified="2015-03-04" version="1">MPEVGDQHLKPKGRTGRCEESVHQVSSYTAQEIATLQSRLEKQLGPEYLSSRSGPGGQKVHYIAAEKCIQLANAVFGFNGWSSQIIDFQIDFIDENPQTLKVSLGLSVVVRVTLKDGTFHEDIGYGHVENFKAKAAAFEKAKKEGTTDALKRALRNFGNVLGNCIYDKEYLRQISKVKPFSPKWSEDNLFRHNSFVTSSSSKNKSVVGSEIINPIINRTKQIGHSESGLTRAGDVPDDFFEEDFGDFDEADFGVTDPDCHPDEVVLSETAPLSAKSSLKSPKLSPKLDDETKNKNTRTMIGGDCIKTSSSVDRQISQQLNILPTAQSPKISNSKLANLDPTLCRDSVSQNRVNRQPSGNPASVNRILNQPNRTSNINQTSSLNSPELADKSIPDFPKDNITPNTPNLKSGFYSARAANMFSPIMKNESSSLTEIPDIIPYNAPIFNPHAESPSIRKTPGVDHKSSKPLTKDLKHISSASQASSASVMIGNSNSGVVSTRSNILNPNFDNVRRIGAPGSPGHIGMSSSKGTGFKIPMKRNTEGGIGRTTNGVNRVPLETLSANTNTNGSTIDIDPKRQKLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P619</accession>
    <name>A0A0B1P619_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001025">
        <property type="protein sequence ID" value="KHJ34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P619"/>
    <dbReference type="STRING" id="52586.A0A0B1P619"/>
    <dbReference type="HOGENOM" id="CLU_015980_0_0_1"/>
    <dbReference type="OMA" id="AIYCADE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="646"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="775" mass="86478" checksum="D236663713C4C508" modified="2015-03-04" version="1">MTHKPQSLESVLDEERRHVLALIEEARIRASSDSARSENGAQPVRSMLQFDLPIPSNRNSTSTSSIGESMPLITPVRSMLDINPVISPIKNTSSMPDLNASKFITTSYRSMLDVSPTGRSPLSFDARSDISPRALPVRSMLDVSPMVQNYLVSSTRNRSTSPRSSSSRCAFDFSPNTMLSLSSSENSYKSQFTRTPLSQREFSPTASRNNSYTRKFSSSMSNADYEFTNNLSSYLPSDASRPLTPKRSAQAGKRSSTPSAMMDAVKNEYFSFKDWDKHRTGSKNGMINNKSPHGRFSKRSITPKFSESAKILIKEEIIDKPRRLQRRRSDANLISSSGVKLSLPKVRRRTFNGTTTLPNDSRLPKETTISEVENAIVVSSDDSVSDDETVQRGRNVKNKSTHEGYKVSDRSERDKESNNAFDFDSFVNKESKDTEKKLSLETENELSSRSEVTTKDPSETLLLAKKLNDLLKMSSDECDSRSNTSYDSETEAGISDIKHAQKLPINTTACISTPATNRCVRSIHRGDFIKMQQEARNNQRRIRKYLVAVDLSEEAAHALEWTIGTVLRDGDTLLAIYCADEEVGISTNDSSLDNITQEHITGNAISNIKSTIPLSTQIEPLRPQSYQAPGSRTSSTTENIDRNPEKNKAEQQRRKAVQEITDKVSKFLRRTNLQVKVVIEVIHCKNPKHLITEVIDFVSPTLVILGSRGRSALKGFILGSFSNYIVTKSSVPVMVARKRLCNASKYKRPSIRLANNIENPHQATDSRTLAAAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6A1</accession>
    <name>A0A0B1P6A1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001780">
        <property type="protein sequence ID" value="KHJ32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6A1"/>
    <dbReference type="HOGENOM" id="CLU_125059_0_0_1"/>
    <dbReference type="OMA" id="ERPIMAP"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="14040" checksum="227B93EFC777815C" modified="2015-03-04" version="1">MGYSLESSRPLITSNAYSQRNSAHITCYNDSVGLALTPSLNSLDSAYQEFYEIEASMQKLENKKLTTQRFIPTQEKIEFLSKLAFSAKLERALERRLIGQDAVMRDRSLQVQKEQSEKIVSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6C5</accession>
    <name>A0A0B1P6C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative bar domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001750">
        <property type="protein sequence ID" value="KHJ32890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6C5"/>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="OMA" id="QEYDYYN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="379"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="439" mass="49998" checksum="12F022D535290096" modified="2015-03-04" version="1">MSFKGFQKTLIRAPQSLKYKLNFGEQTKDPVYIDAERRFQDLERETKKLHDESKKYFEAINGMMKHQIEFSQAIAEIYKPISGRLSDPDSLVEAGNIQGIQACEEYETTVKDLLASLQPELEMIEIRIVRPANELLDIIKAIRKTSVKRQHKQLDYDRHRAALKKIQDKKEKTLKDEQTLYKAENELDLATQEYNYYNDLLKMELPKLFELEREFIKPLFQSFYYMQLNIFYTLHEKMQGCDIGYFNLHIDIEEGFLMKRADVCERTEALSITKFKTTGVKRPPKITPKLGAPPERLAIEGSKPVAKPATKPTKLPLSIKAPLPQANDDDNATPPPPYSAQTSPAGPSNFINTSRGISMKNKANAPPPKPKPARLNGSPKPETVLALYDFEAQIDGDLSFKAGEIIEVISRTDNENEWWTGKLKGKQGQFPGIILSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K9</accession>
    <name>A0A0B1P6K9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001157">
        <property type="protein sequence ID" value="KHJ33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K9"/>
    <dbReference type="HOGENOM" id="CLU_1807659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="143" mass="15841" checksum="F7ED93BA7F2CA499" modified="2015-03-04" version="1">MVFKRALPSEPPDAGNRVSKPKPTLGRISRSTAAESHLLLATGNAFGKSVTNEKMHSEEYRSSDLNYYSDNNMESFTEEKASKTPENGLPKEGFSELFGIPQTRNDARTPRATQNSSDESQLGAASLMETCTHPHLIFQRHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T8</accession>
    <name>A0A0B1P6T8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EV44_g1050</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="JNVN01001126">
        <property type="protein sequence ID" value="KHJ33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T8"/>
    <dbReference type="HOGENOM" id="CLU_049944_5_1_1"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KHJ33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="26764" checksum="D4EFA1E0E64E34EC" modified="2015-03-04" version="1">MSKRSTNSRLANDATEESSIRDAGEERQKKLLQEDTGHFSLIRMLHLADFITELNGFCGVMSILSSMRYCLGSPSAYGNLWAALAFMPFGLFFDFMDGKVARWRKKSSLMGQELDSLADLISFGVSPATAAFAIGFRTPVDHFILTFFVLCGLTRLARFNITVANMPKDSTGKSKYFEGTPIPTSLSIAALMGYWLSKGWVLEKLPLGIWAPGTIFEFHPLVGLFVLSGCLMTSKKIHVPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P730</accession>
    <name>A0A0B1P730_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001074">
        <property type="protein sequence ID" value="KHJ34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P730"/>
    <dbReference type="HOGENOM" id="CLU_000690_0_1_1"/>
    <dbReference type="OMA" id="ERISHST"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="909"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1214"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1387"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1606"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1702"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1387"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1408"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1618"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1713"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1779" mass="202751" checksum="3FF2867CFA7072E8" modified="2015-03-04" version="1">MSNMAENDGDSSPKAQHISPKIAPRKSSEGQHNMHPIKIESDFSSEQDPATFNWHQSSYDLDKNANKPANIEAIDYMNGGNPHECVSPILDNEVKVSSELLVSKPSQVSLHDELAKTITTARKSVQFMRLDPAAPEVISHVTKSSNEDFDTYHRERKGQSLISKLKALTSTAGSQICRQQASASSPSEELSIYTPRSPTFDRLAKLSQILRQEDSDADADAEETADEDHVTGTSRTKKKMRFKRLQIERLNGSQTTPATPRLHTLGDVDLPLSGNRNVHFFNRRATDGFIYQRQHFSDGEGEDQLHSHRAWRRSSHWIIRGRGPNISRGQDSQQGDFGSSSRRPYNNFKRAMTGIGGGGGFSDGDNSTPKRPFLGSERATTFGAQRWRMIRQGLKMLGQKKEEHKVDFLKSAELMAELRAGAPAALMLASMVQRDEHGNKRIPVLLEQVKIQVTESKPSVDESVDSERHLIFRIDLEYGSGLNRMKWVIHRSLRDFANLHIRYKLQGGSDKYIQLRSDIDSRPKQPRFPKSAFPFFRGVRGLGDSDEDDVEAAQADDTVGEGTHSENDNVKKKRGRFLNNNSRRKSSTNIFDTSSTVHGVHQIRVYNEKQRRRLENYLQEMIRWLIFRADSNRLCRFLELSALGVRLAAEGSYHGKEGYLIIQSSKGLNTRRLLSPSSVLYRHSPKWFLVRHSYIVCVDSPENIHIHDVFLVDSKFEIIQKHRKLTDFSMRSVIGQAENAATHPQHHSLKMLNSERKIKLLAKNERQLRQFEDSIDHMIRNTCWSKPNRFASFAPVRTGIFAQWLVDGRDYMWNVSRAINMAKDVIYIHDWWLSPQLYMRRPAAISQKWRLDRLLQRKAREGVKIFIIIYRNVEAAIPIDSEFTKYSMLDLHPNIFVQRSPNQFKKNQFFYAHHEKICIVDHTVAFVGGIDLCFGRWDTPQHSVVDDKPTGFEQSDLPKDADHCQLWPGKDYSNPRVQDFYQLNEPYAEMYDRSKIPRMPWHDISMQIVGQPARDLTRHFVQRWNYVLRGRKPTRPTPYLLPPPDYDPNDLKDLGLTGTCEVQILRSASDWSLGLTETEHSIMTAYCKIIEESEHFVYMENQFFISSCETMNVKIVNKIGDAIVERAVRAHQKNESWRCIILIPLMPGFQNTVDEPEGTSVRLIMQCQFRSICRGEGSIFGRLRSHGIYPQDFVQFYSLRSWGRIGPKKILVTEQLYIHAKAIIADDRVALIGSANINERSMLGMRDSECAAIVRDTDMIWSVMDGKPYLVGRFAHTLRMRLMREHLGLDVDSIIEEERQADLKREEKSENQKNTPNSRRDEYTRKNSSNKPLGQSEFQENKNSYSRRLQEDEQTLSTKNGKDKNIVKDADIHVQNVDDNISHENALTEAGVTSKQGLTDSLNQDNLENSKESNQHINSDHKSDAEIVNISDPGISFIPEKTKNNTPHSGYAHLPKNLVPTLNADLDSRGPPLRPNVSHQPDIDCFNPFTADIKPASLDKDCMRDPLDDNFFEDIWRRIANNNTKIYRRVFRCNPDSEVQAWSEYRNFVSYGARFIKEQSGEANIIENDTQNLHGKNSIIGAPIVSTAFSDTKSGIENSEKMILGGQSKSNHMGGGDHLVEKETQDNRPRSASQSLNNHMSVNTEPAAMVISDDGISLSAQPLGNEAFPPLENIMDESNLEFENSSLPPSRKTACAPITSEKLVSSSSGNGTVRRRRRTTRGSRKTFSSSDDLLSIADCEELLSLIQGNLVNFPYDWLVKEELNSNWLYQVDQVAPLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P796</accession>
    <name>A0A0B1P796_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P796"/>
    <dbReference type="STRING" id="52586.A0A0B1P796"/>
    <dbReference type="HOGENOM" id="CLU_022882_2_0_1"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="166"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="334"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="551" mass="62502" checksum="44736D7546CBFD58" modified="2015-03-04" version="1">MADELTCTDIESKETAPEVSSKPNGNDSVEAKVQDEQSNSVVVSSTKKKKKKTKKERGKDTEIDTSELTSSASKLVNGLSKQQVEELLRLNPALSQQLSVEDGTNLTSEKIQETLKQLKLEDIMTGLASSGKNVKDMASYKFWGTQPVPKFGTSEKIMEEGPIKIIDIEQVPKEPGPLVDGFDWVTMDLTDDKEIEELFTLLYGHYVEDDGSLFRFNYSKSFLKWALMSPGWTKDWHVGVRASASRKLVAFISAIPVALRVRNNTLHASEVNFLCIHKKLRSKRLAPVLIKEITRRCYLRGTWQAIYTAGVVLPKPISTCRYFHRSLDWQKLYEVGFSPLPAKSKPSYQIRKYALPETTSTKNLRPMESKDIDGVLSLLRRYLNKFQLGLVFTREDVAHWLVNKKISGSDQVIWSYVVEDPTTKNLTDFFSFYALESSVINHNKHKSIRAAYLFYYATEHGLSNEMPHNEYTIHLNSLINDALILAKKYKFDVFNALTLMDNNLFLEQQKFGAGDGQLHYYLYNYNTIPIAGGVDRKNSIEGLSEVGVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P804</accession>
    <name>A0A0B1P804_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001400">
        <property type="protein sequence ID" value="KHJ33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P804"/>
    <dbReference type="HOGENOM" id="CLU_1166592_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="238" mass="26562" checksum="1A8213AFF33B36C5" modified="2015-03-04" version="1">MDMLIDSHLEDIDSPSNIDNIVLAAQPRLDSSLWNKDQSLPELNNTTQTSQMNQTQDMDPFRSDPIAGPEPSGGEQFFSQDDKLSNNRKRHNNNEIPIPLLGTKFIKIAKKYSGDESQVVNSKIEKARDLILEACSLTSSRKKQTSLLDLLEVFRHYTEKGKIDNRAPKRDNVAPIGGKNMLYCDTFTPQITIDTNARDYPSLHASYAQAAAAATRTTTQPSKQQKATNNTSKITHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P818</accession>
    <name>A0A0B1P818_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001618">
        <property type="protein sequence ID" value="KHJ33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P818"/>
    <dbReference type="STRING" id="52586.A0A0B1P818"/>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="OMA" id="ECRINTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="28188" checksum="C0B10D259CFEFE78" modified="2015-03-04" version="1">MPLDTSTYSLALLRLDGRRWNELRHLTAQISTQASADGSSYLKMGNTKVICTVTGPSEGKLASRQTITTAGGGDKADIQVLISIAGFSTVDRKRKTRNDKRIFELQNIIAGAFAQSIFTNLYPYSVISITLDILSQDGSMLAALINATTLALVDAGIPMRDYISACTAGSTSTHSDNDEMADPLLDLNNMEEQELPFLTVATLGVTDDISVLLMETRVQIRRLEGMLVVALDGCKQIRQILDDIVRFHGKKFLKDKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P885</accession>
    <name>A0A0B1P885_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001601">
        <property type="protein sequence ID" value="KHJ33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P885"/>
    <dbReference type="HOGENOM" id="CLU_1696809_0_0_1"/>
    <dbReference type="OMA" id="QIDTHVE"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Get5 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="155" mass="17367" checksum="F0B8BC25B166C36B" modified="2015-03-04" version="1">MTELSFAKSFLATLNSYPTKISSEYVEDPKKYPLRATFTLPKHTQPQPKKRDLKSHTTSVLNVHLISQRNPPLDHTLSSQPINMTMLEIKNTLSKMIDAPPEKIKLLHNKKPVVDNKQLKDLLATNIEQIDTHVEIGDTVNLGVMVLGGASAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A3</accession>
    <name>A0A0B1P8A3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001591">
        <property type="protein sequence ID" value="KHJ33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A3"/>
    <dbReference type="HOGENOM" id="CLU_128909_0_0_1"/>
    <dbReference type="OMA" id="VEPFINW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15644" checksum="5AF01E7C1474EA9B" modified="2015-03-04" version="1">MKWLDAKYFSLISEVDVPTHNRGNVLDLCFATHSLLAKGVSSYVQHDLDTTSDHIPLLITIPLETRRSHVEPKLRFSTINEKKFQFLLLLNISRMEPLQNKSPSNIDKRAEELVNILQSSFAGSAKKSLAEVLENLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8I4</accession>
    <name>A0A0B1P8I4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amp-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000575">
        <property type="protein sequence ID" value="KHJ35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8I4"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_1"/>
    <dbReference type="OMA" id="CGAPIVY"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="481"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="584" mass="64823" checksum="398B98685EAA277C" modified="2015-03-04" version="1">MSSPKSRLKAVLSHLPPNQSTQVRKLNYHALSPTIFLPRAAQIEPLAIAIHHVSIDGVLVRRTYREFADRACGLAYFFLKYAYRRIGILAPNTPAFLESIFAIGAAGGIHVGANYRLKPEELAYIFAFAEVDCIVVDAQYKSLLQLFLKKHPNVHIIIDTDNSQVIGDSVNSYENSIREGTLWDAQTGNNGWNNLSVHTVDEDSCIAVPFTSGTTARPKGVVFTHRGAYLAALSNVIESGLILENRKRCGYLWTLPMFHAVGWTFPWAVTAARGTHYCLRKIDYTVIWNLLKSEPITHFNAAPTVNTFLCASKDAICLPTPVRVTVAASPPTPYLLQRMTEINLIPIHVYGMTETYGPITKNYYKPEWNSLPSQEKYARMARQGYGFITSLPIRIIRTDQPDDVLIDVQKNGQEIGEIVFMGNNCAKEYLNDPEATKKLWAGGVLHSGDLAVWHSDGSAQILDRKKDIIISGGENISSVALESMLARHPAILEAAVVGVPDSEWGERPVAFIICKESSEILKPLAVSSPPSISRDILEWAKKESSISRFMMPREIHIVTSLPKTSSGKVKKNLLRKWAVGDVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Y2</accession>
    <name>A0A0B1P8Y2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001610">
        <property type="protein sequence ID" value="KHJ33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Y2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Y2"/>
    <dbReference type="HOGENOM" id="CLU_006383_1_1_1"/>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="455" mass="52146" checksum="1D8E4B2F48981039" modified="2015-03-04" version="1">MPLEGIAAGKEGMTYSMSNVEDTQICVVMVGLPARGKSLIAQKACRYLRWLSINTKVFNVGYYRRKQAAKPPASFFDVNNPEGERLRRAAAEEAVKEMLQWFKEGGIIGILDATNSSISRRKWIKEKCDEQNVETLFVESKCDDQDLILSNILEVKTSSPDYDGQDPEEAARDFCDRISNYEKVYETIGDQEKHLTYLKIMNVGSQVIINAIQDYLQSRVVYYLMNLHIKRRSIWLSRHGESVWNVLGKIGGDADLSPRGEEYARLLPELVNKSLRGESRPLNVWTSTLKRTIATARHLPSYFNQLQWKALDELDSGVCDNMTYAEIKEKYPEDFEARDHDKYNYRYRGGESYRDVVIRLEPIIMELERSENILIVTHQAILRCIYAYLMDKDHVKSPWMNVPLHTLIKITPKAYGCEVEMFKTDIAAVSTWRGKGSVAKHEDPTEATVTLGAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P917</accession>
    <name>A0A0B1P917_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative rho1 guanine nucleotide exchange factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000722">
        <property type="protein sequence ID" value="KHJ34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P917"/>
    <dbReference type="HOGENOM" id="CLU_001083_2_0_1"/>
    <dbReference type="OMA" id="DMFYHPG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="780"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1249"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1599" mass="180269" checksum="B499F854B25BDA6C" modified="2015-03-04" version="1">MSPNIRVSNSPSDNPAVYEITQSPPGQASLSELELNFEHAHYSPVAPASNSRYQQPTSFYDGESTSSSYERLNLSQTIQPDFKMNHTKIRELAENCDSSTTEKYHRKDKHYASIDRLNDHFDDDPLLRQSELISGRFYGKEYPIPNRSSHMPRIMGSLSPNDDEFHRHPNLRPLPKAPEQNEEDDQPEMISPIFIDRQKEQEKLIAEIGDALRSSSLRRERPIAIHQSNGDISQNELLALQHSQSRDKDLINESITASLDSPFIAQETYFDDIDNSDDENESDFEAAAGLEAMRIADEQDLYCCNEIPNFGNHDKIIDNHQEIMDLTSAAGDYDIRISYGQDIPIKNTMEFGTGARKLDIKLNLSHDMMKSRSNDSFSLPGRSMTLTEPIVDEKNYFSSSEGNNTELYDTARTQSLVPKPHRMSFDEGDEEVSLYSRSFHKSEGNDLPPNSLPELFYHPGMRSSAKNRPGNYERPLPPIPLLDDKTIQGMILGQHQRNWNIENSLIPNKDSQNKSSLNEGLGTNGLQKLSNRVGVNISRASSLLNQGTIPYTAPPVRSKTDAEERQLRNKVTGTGMNITSGLDNYNIGSPQSLHAIDLPSLPIGRHKKFSASRLSSKDFQKCKEPWALSSIASWIKHVAGSETGEGEADLKTKAIEEGLVALFTHIVPTMNTADAETLSQRVSKSMLDSGLLVQEEEWVKFGNGEVSGVLWQLTGSGCYSPKVHENEVHGRCYSYHCTRTLKKLNFQSKVLEPSRVSEDWMTFHKLTAEQLEGVKKKEIQRQNNLHEIVMSEDLYMDQINVLRVLYRDELSSWEPSIIAKEKLSKFVSAVFGKVQAIKAVNESYLLAQLKYRQKEQGPWITGFSDIFREWIRKAKLIYIEYAAGFPHACYLVRREADRNLLFRQFLDQARDNKLSGRLDWNTYLKAPITRLQRYSLLLGTVLSNMTQESEEKSNLILAIEEIKAVTLECDTKVDENTKKVEMLELRSKLILRPGMNDIELNLDHLGRKLIFQGDLLRVGANRFTWLETHAILLDNYLVLAKTIAKGDSIYGRKKEGYDVSKHPIPMQLLILESTTDDPVIKSSVKGITAVAKTGPINAINLGQSRSTWDVAERNIALEFTSSNQSTTQLSSIPRTLSISETDTRLMYPFRVKHLGKAEVYTLYAPSAQNRMEWCDKILQAKIQFTASLHEQNAEPFRLRVMADCAFALDTLSMIPQKNSVSVTGTPLDRAIREIENDYGAGPRPGPICRTAVNCATSFNFYGKTIVAIGSDNGVFVSAERDPRGWTRSIMVSRVTQIAVLEEFSICLIIADKALIAYSLDMVMPNSEFSVPPQESVRRAPMKLSGTRDVSFFATSRMKNRTLIFYKKREGLHSTFKVLEPVFQKSSEKKSRLLGRIRGGSTDFFRAYDEFYIPTECYSINIFHSYIAISTLKGFELMTLDKKLPMSIPDTKDPAIASVTARISGLRPLGMFRLSNVEFLLCYEECGVYIDKHGDVSRSVIMEFVGKAKNAAMYGAYLVLFDTDFIEVRNADNGRLRQVISGKDIKCLDSGVSPLGTGATLAEMEKRTLKFVMAHPEISSSQLVLEMELTKGYCCNLMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A2</accession>
    <name>A0A0B1P9A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative zinc iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000692">
        <property type="protein sequence ID" value="KHJ34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A2"/>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="OMA" id="SCHSHGE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="57677" checksum="C06DB75A9BEF7454" modified="2015-03-04" version="1">MLIPNTFHLGLYISYFLSRRVSAISYPTECHSEGGRVACVNHNSTNAVDKAPVSAPTTKLEKIASGSNPMLSANPSNEVSSPSADPLLDTISACYMKGATQFCKDGVGNSVWVITTALTSPFPSIYTGCYTSEAGSKYCFSPEGTQVEVLAEEASEVPETERKNNSFEGHREIKRHDHGHGHHSHGHSHSHSGHSSANGAESSKVDCSKHTRDYNVNLRIGLLFVILATSAVGVFTPILLEAFFKIRTEGMVFTFIKQFGTGIIIATAFIHLLTHGGIMFANPCLEELQYESTATSITMGGLFLAFIVDYLSNRLVRWQRMKAMPEITDKEKDAELDLSSQLKSEGIIHHGHGHGHGHGHGHGHHHHSLGLINTNDSSISLLILEAGIIFHSLLIGITLVVAGDSVFITLFIVIIFHQMFEGLALGARIAAANNGEFGNAKSILLPLVFSFITPLGMAIGIGTLQSFNGNDVATIIVLGTFDSLSAGILIWVGIIDMWAGDWIFGDLADASWPKTLLGMASLVAGFALMGLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F5</accession>
    <name>A0A0B1P9F5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F5"/>
    <dbReference type="HOGENOM" id="CLU_2361299_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="96" mass="11328" checksum="334CA04E03AC2DD1" modified="2015-03-04" version="1">MIKNAVYTYEIRLWKERDLALKKLDENLKATVGDQFKQHLMGEITERVKLKSPFENVMLAVASVKADLKAEFELFKSIPYRKPVNDYFSLWQIFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J6</accession>
    <name>A0A0B1P9J6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative c6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001523">
        <property type="protein sequence ID" value="KHJ33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J6"/>
    <dbReference type="HOGENOM" id="CLU_007604_0_0_1"/>
    <dbReference type="OMA" id="CIHSVLP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="631" mass="71543" checksum="3E03BE53E0C093D1" modified="2015-03-04" version="1">MSSIKQVQDLEKQIAQIKRENSYLRSIVSQQNKQICKENEGQQALFQLPVIGSRLKKRLRLPPTKGLLIAQTNIQKYSKGILKLPLPSKNPSNANLFASPKPNLLQKHTSDLILHSYYNSIHLVMPILHWPTFLNEYENVYKIGSFQNALPEWISLLYTVLAVGSLFNKEQAAQQTNKGREFIDISLTQSDNWSDDFTLDHARAAILTSIFLVEINLKSAARRWLAIAVSISQEIDLQTEVGSWSTSELEMRRRVWWGVYIWDRQISLEYGRPPFIKDTDISVNLPTAAEDHQIYEAGILPPSNPTSCNMILPILDVIRAISPLIEVLRTPIIPESTLKIFDAHFAACIAAFPPSFVLNSHEPLDPQALVPMCYLMNARLVLHRHNLTTFCQQDTRFNAIEQCLRTSLDSAALISRAMAWTKHSQSFDTAAHAMTCTHIWRCTLFLLYGGQFDAALTCIRASSLIGTLRDVNICCGRNIAFFLDVLIERRRSGSLLGSRDFRDQSYLDEELIAYLSGDLQANLDNSWIWQENEVGLDMDESKGRDDTLPNFSMREVIKSEESKSIYTELDMKNWGGWQRIEYQVGVLAQESDGHVNLSSRLYHSSGSSSITTASSREQLKGNERMSITNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAH7</accession>
    <name>A0A0B1PAH7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component sensor protein histidine protein kinase (Dhkj)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000462">
        <property type="protein sequence ID" value="KHJ35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAH7"/>
    <dbReference type="HOGENOM" id="CLU_002763_0_0_1"/>
    <dbReference type="OMA" id="KRAAIWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="637"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1184"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149689" checksum="F4B8903982AF42A7" modified="2015-03-04" version="1">MVSCEAPPKLSHIEGISDYARARELYKYYQPSVQTYIPTFEDVENEHDINISSNVSSSKLSSPDTALTVFCQLTAWRMGFQRAMISLIDAETQYFVAESTRTLDLINNDVHAPGDGLWLGCSSVAKAGRLCESTIAVAATKDNTYPHFIVNDLSKDERFNQLPFVSGPPFLKRYIGVPLITKRGIPIGSLFVVDDRLGDGLSEENLAFLGTMAKTVMRHFELVREVEEHRRAMKMSHGLSSLIEGRDELFETNIEKSDTEETNIGRKSKSQYSCCDKRSRDSIMNQRSCISKKNAKQAVSSEKREKNVHDIKMTLNCKVPGKVDLNKDNPKISQSRSIENSCPGIASSLILDKIAAPPENDLEDLSIRALFSRAAHLIQMTFELDGGTVFYDARAGSSETVSVRKTNSTPSGHRINSQFGSECSTSDDELEPLRKLKSKANHGSAPQDLLLSGRSTRSKPENSFYPHSNITMNKRVEILGYSTSGNPSTHEEKFPGHQFFKPLRHKNLQRLLRQYPRGKIWAFNADGTDSSSEQSSRSVGKNSELCSKGAQSKTRLRTNFLSWHFPGVRQLLFIPLWDAGRSRWFGGCFTWSKDPTRILSKQNELAFLTAFGNCVMAEWARIDTEIADQKKSDFIGSISHELRSPLHGILASVEFLEEVLSGWEKQLVETIESCGRTLLDTINHILDFSKINHFESHWRRSKRAKFRAGVPVTVEQSDLPMLNLFQDIDISVICEEVIDSVYAGHVFQNITAQSFNQISDTQGKMSDAQQYLTYAEHITKSRNLQDGVLVILDIDPKNYHVTTQPGALRRLIMNLLGNSLKYTAHGYIIVRLDCHEIEDFVTTGHNGVEESIPRSMLVFTITDTGRGIAPEFLRNKLYIPFAQENILSSGTGLGLSIVRAIVSLLEGEISIDSEVGRGTQVKVSIPVLRKMPQIPVSLEGAADSTKKRPQFFHDAVLDLRSRFTGHKVGLYGFDDITEDSILNEKNRMMKESITNYLVKWYHMQAVPLKEKVDFIIANSANHSTISSLALNAVKVHGNYPCIIVICNQSLVRDRIYTVEDTQCKVGYTAKPIGPTKLAKAMIQTMNAQSTLMVHNFESKEIETSNLVGIIKKDSMDHQGENDKAAEVRPPPKIIEQPIVKLQSGCNDSALHRKSNDIVSKKDTVLTNLDIPKSTALGSQSKSPSILLVDDNQINLRLISTYLSRRAYPCVDTAQNGLEAVQRFEAFSDGYDIIFMDITMPVLDGFGATRKIREMEKKMSSSARKSVTKETMDTFVEQKRKPALIIAFTGRSSTEDQSEAIRSGIDLFMTKPVPFREVGKICDNWIANQIQPDTTTSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS2</accession>
    <name>A0A0B1PAS2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative nad h-dependent d-xylose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001068">
        <property type="protein sequence ID" value="KHJ34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAS2"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="DMYLVHT"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="36690" checksum="97B86E55BD9C5E0B" modified="2015-03-04" version="1">MALRSPLIKLNSGFSMPQVGFGLWKVSNNICADMVYSAIKAGYRLFDGAADYGNEKEVGQGVARAIKDGLVKREDLFLVSKLWNSFHDYDKVEPIARKQLADLQIDYFDLYIVHFPIALKWVDPEVRYPPGFFYDGKSEVRLSNASIQETWMAMEDLVNKGLTRSIGISNFQGSLILDLLRYAKIRPATLQIEHNPYLVQPTLLKLAESEGIVVTAYSSFGPQSFIELEFQKAKDTPRLFDHDIITTLATKYKRTPAQILLRWATQRGISVIPKSNNPDRLIENLDVTGFDMQKDDIESINTLDRNLRFNNPSDYLGTLHIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT5</accession>
    <name>A0A0B1PAT5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000858">
        <property type="protein sequence ID" value="KHJ34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAT5"/>
    <dbReference type="STRING" id="52586.A0A0B1PAT5"/>
    <dbReference type="HOGENOM" id="CLU_525997_0_0_1"/>
    <dbReference type="OMA" id="CACANCT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="518" mass="57742" checksum="B4BB33EA61791DCA" modified="2015-03-04" version="1">MMSNPPLIRASSSTKHRSYSSKPLPFPPSLSSPGLELALGSPENGKPPPVPPKSARPFTPNKSLNNVYQQPNFSQPLKSDEDTPGLSHSWSDSSVEGETDHLFDSNLEASYDHNRVIVPKNVDSSTVILSTSHSSDSSPTIQASSSLPPTQPGLWLRRLARKTQDPALIQSTLPLNHLHLDLDQKEEKLLQYQQPNYLDQNKLIQSAKKDLEAEKETTPNIIKLEPANTTDLSIQLDSDLMGNKFAKLRSKNLGEFSTNSSHHEDAPKSYIHESRIKSTNFEKAKSHKSITRNLPRSSSTSRTYNEKAPPSLPQKSSSRRHIISPPTNFSKPDSNSSTHTSFPSSGSTTRAPTILTPPSSETLALQSDSNSNFLTQTPSDIRDGTVPEIKLYPYQLKSDVLFSPQKTTSTTDSSEKSWPLIVSKLAPAPEIVERMIIPGPPLNIIHFECYHEHRNLRKTRNQMCPIGCMMCHKKDTEIRWMCTWCYLCACANCTRLLTQTPNRNLKATMVKLESLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAV2</accession>
    <name>A0A0B1PAV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor bzip</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAV2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAV2"/>
    <dbReference type="HOGENOM" id="CLU_586781_0_0_1"/>
    <dbReference type="OMA" id="IDMIASP"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="379" mass="43567" checksum="12E7B490634DDE2D" modified="2015-03-04" version="1">MNLITSTYQQQKHYPLKLKLNMESTTEKEERKREYNRLAQREFRRRRKEHMKSLEQAQKELSSERAEEIERLRLQNEELRKENSVLRAQIYNSTITNQQYLPTSSSFDSRQYSLSPSISCNSMSGAGSPPSMMGSDYLPMGNLSIPTSMIGQSLQTCTEHDMTAQPYSMVLYPGVRHNTHCSPESSGFRISHNSVEPSSFKQLKIDEDTSFLGLTPMKSKSLPALTNNVPYDRSKARSELCERFKTLISDPSICYNPQRHFAILQTMTNDLPAPLKPTKRQLETAHYHGIDMIASPSLRDRLLSINNEAAYNFVSELGIISSENEDTCALTIWGDDPLNELNWELSKSFLERWGWLVGNEWIYRSNSWRNFRGQPNISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB07</accession>
    <name>A0A0B1PB07_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB07"/>
    <dbReference type="STRING" id="52586.A0A0B1PB07"/>
    <dbReference type="HOGENOM" id="CLU_514793_0_0_1"/>
    <dbReference type="OMA" id="IAALICH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="520" mass="59933" checksum="2B531BD9433631B1" modified="2015-03-04" version="1">MESPLSQASIESQAIKKANNSNSSIPFYELQDVVKWSKNASENLYVIEETTIFFPTANSTRLANVLTQAQPHRKLRLQGQIVVDSDQENQLIVYQNGQNLNGAWIIHEGDFSNFSIGYPNTLWIPTSLGHLEIRTSLEYHEVFTQMMHAIGIYYVALFHYEDYEFTDENDKDFNHVAAILNFYSIYVDGRGLFFKEVIKIVTKYAKFMLNEYSKEDSKGALIEKHMFFKWLRDGCKTHKGIPITDTQNRDLSPEQYRQYFEKARQRMRKKYSSPEPSSNFSEPPPYQSESSADHLTHQARDQTTVFTVRKECNLKRPFYGDYISPQFPDGINDESSISEKIAALICHTVSSGRKQLKRLSISNIASALYSDYSINYRPVSHELIVIYRASIAAYLPATYPWRTSEIYRELIASNTPSALSRNHPLFTKIQESIKHYVDGKKKLLHRENKFTPSASDKPIKKNQSTQNYIKYVAIPMPELQNRDPSIISLDPKISNEEPAGICKKYYGIQRAAYRSLGIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBC4</accession>
    <name>A0A0B1PBC4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01000779">
        <property type="protein sequence ID" value="KHJ34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBC4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBC4"/>
    <dbReference type="HOGENOM" id="CLU_018791_2_1_1"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="48591" checksum="0031F599041B4FF0" modified="2015-03-04" version="1">MAVLLETSVGDIVIDLKVDEAPKLCENFLKLCKIKYYNFSPIYRIQKDFSFQTGDPIGPDSAESDGGSSIWGVIDGPAKRTFKVDFNPKLKHIEKGTVSMATAVSPKDPDERVAGSQFIITLGNNLDFLDGKGAIFGTVAEASDTLEKINNAFCDEKGRPLVDIRIKHTIIIEDPFTDPPGLIVPPKSPLPSKAQLATVRIGEGDSLEDEVDAEAVEKARREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTTDEDLELIFSRFGVILSCEVIKDRRTNDSLQYAFIEFEEQASCEQAYFKMQGVLIDDHRIHVDFSQSVSKISDSWRSATNSKRRARAGGFGGVSGLEKKRQYKSDKERRGRDRKDKYGMIIDEEEMRKRHEREEKENVERRYRDRSSSPRKHIRTGNGRNDIRMERRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE3</accession>
    <name>A0A0B1PBE3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000347">
        <property type="protein sequence ID" value="KHJ35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBE3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBE3"/>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OMA" id="FARCDIQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121724" checksum="500BC5574F63246C" modified="2015-03-04" version="1">MPVVSSDQLISLQRNPEGIRNICILAHVDHGKTSLTDILIATNGIISPKLAGKIRYLDSRHDEQTRGITMESSAISLYFTMLRKSTPESKPEKKDYLINLVDSPGHIDFSSEVSTASRLCDGAVVLVDAVEGVCSQTVTVLRQTWIENMKPLLVINKMDRLITELKMTPVEAFIHLSKLLEQVNAVLGSFFQGERMEEDLNWRDKMEERITSIAKKERNTNLDSANGNNEDVLHPSNISPADFVFEEKDDTDLYFAPEKNNVIFSSAIDGWAFTVRQFACIYEKKLGIKRSTIERVLWGDYYLDPKTKKILAQKHLKGRNLKPMFAQLVLEQIWAVYHATICSDNGKGNPAVLEKITKSLKITLPTHISRSRDTRAILTAVFGSWLPLSTALLVSVIESLPSPLTAQEIRLPKLMDLSPGANFIDPILRKAMIESRSSTKDPKVAFISKMLSIPESELPENKIRRGILSPEEAREIARRKRIEIAQAQALKSEYNYLDSISELSTSKDCELEGVDTHELNDHLDPERLIGFARIYSGTLSVCDFVYVIPPKFSPEYPHKSPEPKRVKVTALYLLMGRELEPLTSVPAGVLFGIGGLEGHILKSGTICSQLEGSINLAGINMGTQPIVRVALEPINPTNLDKMVNGLKLLVQSDPCAEYEQFESGEHVLLTAGELHLERCLTDLRDRFARCDIQAGEPIVPYRETIVRAGEMKPAANKELSRGTVIATSTSKQISVRLSVQPLPTEITEFLTKNSCTIKKLYRDRQASRKITKFDENQSSQPDEEINNEILDDNKVLSLSKFKKKLYETIELVEEQRDLWASSVDQIVAFGPRLSGPNILIDTTTEAICSRFLQDPSVEDKKWVIGEILQAQDFSDKISYAFQLATTQGPLCNEPVQGIGIFLEQVTISSFTKDDTSRDNLGRLTGEIIKTMQTAIRNGFLDWSPRLCLAIYSCEIQASTEVLGRVYDVLTRRRGRVLSESLKDGTPFFTIQSILPVAESFGFSDEIRKRTSGAASPQLIFQGYEILDEDPYWVPFTEDDLEDLGELADKENVAKRYMDSVRKRKGLILSGEKLVKDAEKQKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF1</accession>
    <name>A0A0B1PBF1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dna damage response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF1"/>
    <dbReference type="HOGENOM" id="CLU_007951_0_0_1"/>
    <dbReference type="OMA" id="GIGDHYW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="793" mass="90449" checksum="3C2DD89B5C0BDD7C" modified="2015-03-04" version="1">MWVLECSGDDLKGKKIWMRPGKKFIFGRTKHDNIGDVIVLSHKTISRKHLAIEIGLPSLDDCCNPQTRSKIYIQDFDTKIGTLLNGKQIRGQTVELTKAKNYILLGRYNKSYFVNWIPVTLTFSFSTREYVENPYAKFYKIFGPLDIKILQNYEHNYTTHVVAKKRNTAKGLLALIDGKHIVYNDTFIDALIKATSQKDDKSLLEIDFEGNFPDPIQFLPPKGDEPTQREEAAYIPNELRKNIFNGYIFVFYNQKQYQNLHLPITAGSGEAILRVVNPDQTTVTEFVNFVKDLTRENRLRILGGECKEKRIIVVKYNPANGSEQTWFVGFNQEVSLQLNYSLIEQNEFLDAILANDASFLWRPLQNEGIELIDPPVKSSTNQASSSSSSSNQVNHSPIAGKEPKQAPNPGRVRRTARPKFTGFDDDFSGTPLEISNSLVEPNLIDSNHISPEACISQSQGLFVSQDVNYVSEISTRDLIGHKRKATPNYEEVDDTRSINRLEIISPELKRRRLHTEIEPRQMESILPEPVVAPVVMTILEKSKILASKIPRQAPRKKPADIDAEVEEMLHRKLELDKATSDLLAKAEREAICVELDSLEISEIRNKIEVKELPVKTPKRVERKRVEDCDRWNACWNGRKNFKRFRRYGAGKRISDRVIVQLEEVRKRDYGIFHDFLGETNKPKEYHGNNNSIESRQHFGQSTTRAISTPSLLATTGNQSKILKNNSRNQSVLSSYTTTNSFKRSAAHMSSPDNGVIDNQISMAKKPRLLAIKKSGDESDDESDDELKFRFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBJ3</accession>
    <name>A0A0B1PBJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60s ribosomal protein l24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000317">
        <property type="protein sequence ID" value="KHJ35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBJ3"/>
    <dbReference type="HOGENOM" id="CLU_106411_0_0_1"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17957" checksum="234F051981C57CE9" modified="2015-03-04" version="1">MRTYEDTFSGQKIYPGKGKLYVRGDSKVFRFQNGKTESLFLQRKNPRRIAWTVLYRRKHKKGISEEVVKKRTRRTIKSQRAIVGASLDVIREKRSQRPEARSAARVAAIKEGKDKRAAAASAKKAEKAKLASANAKGQTSRLQSKQGAKGAPKKVQATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBR5</accession>
    <name>A0A0B1PBR5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative rna-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001046">
        <property type="protein sequence ID" value="KHJ34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBR5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBR5"/>
    <dbReference type="HOGENOM" id="CLU_013226_1_0_1"/>
    <dbReference type="OMA" id="AFCIDEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12342">
        <property type="entry name" value="RRM_Nab3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034167">
        <property type="entry name" value="Nab3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="342"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="788" mass="87709" checksum="0E079B304916E49B" modified="2015-03-04" version="1">MTSAEFDQASAVAASSELNPKSANPTENSNPSESSFSDAYNEDAEMANVKNKDTAQLDDDDYAMNFDSDADEHTNRQELQVISEAKIDSDITSLPSIVSATNLSSTMPPETTISKNSLNGTVTHSLHLNHTFSDQNSAIVASNPEITNTAQTPIESLGVKSQNFDDFSAGGIDIQQLLDNITANAEKPDSPHLKNHSLPIHASLPPRPNVPQNRIYSDEGAKYYVGAPSLPPASISSRPGGAPSLVAAGAPGTSTDPRSGLPPPPSVSFRGQLSSANSISPNTHMPVNRSSLQELPNLADQDEVDYFETKWAPEVQKMYDEFLEDERRYVTEGLWDRFPMGSRLFIGNLPSEKVTKRDLFHIFYHYGKIAQISIKQAYGFIQFLHSDHCYRALDCEQGSEVRGRKMHLEISKPQKNVRNAQSSGQRAKSPDRSSGGRNYRNNDRYDRQTQMTRTDEYGRPLRVRDDYRPVRSITPPRGTNRPRDPYDNRDRRRSRSPYNHRENSRYRDRSLSPRLRDGIDDFNLVIPRRDPRDVPDVQIILMEQLDRQFVSWVENELHSRGIKTEVMFLSPRVSIEAVIRRQIFEGVHAVSRLSSTSQNSSKIPLQVFDRQGGVNNVRFDEYENLEPKIAGELVLRAKQNHTISQVQAPAYSQAPPYSQANFSNTTYQSPVVSAAPNIASLVGSLDNATLQKLLGSLGTSQQQPNLPVTTPVAQTSTIDLAGLLGGLKNHSTNQNYALPTQTELYNNSGHSIQPQFRGNNVQSTLSPTQPQPAQQVQNIMAQLARFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU0</accession>
    <name>A0A0B1PBU0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000123">
        <property type="protein sequence ID" value="KHJ36167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU0"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="123" mass="13820" checksum="33EE568F6AA2AB6B" modified="2015-03-04" version="1">MKASFLLKENTEVIATCQRRERAWHACLKFYKFVISNIDSTLTLLVDAIEKEKAVAFKAYIRLAIANFAASDSASTLPRIYSHSLLIKSNGSNSEKDKNIVKKVIINDLSVRTKESMSHAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBW7</accession>
    <name>A0A0B1PBW7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000115">
        <property type="protein sequence ID" value="KHJ36192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBW7"/>
    <dbReference type="HOGENOM" id="CLU_1152469_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="241" mass="27813" checksum="87A1AD50DB0B8E57" modified="2015-03-04" version="1">MVTSLQTEILGLKASDSSTRVKAKPVIELGESNIFSDPNDPQISSNQKSELYRIDEKFTRLDKSQYPAFQRHFRIAISQNADRYITLQLKIALIYQNLGQEPRSFLDQLLDDNGKFLFSNVQDMWDTLDVSYRNPNEKEEARAILCSLRQKGESFGAYLAEFQKYRNLSGLTDNGTLVSLMRAGVSREMQTRISQQQKTTKEYTYYKFVDLCKECQLRIDLDRPFSQLNQTNQPSYQPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBX6</accession>
    <name>A0A0B1PBX6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBX6"/>
    <dbReference type="HOGENOM" id="CLU_2387802_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080596" description="Cytochrome b mRNA-processing protein 4" evidence="13">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="94" mass="11262" checksum="FB101A6B5097D169" modified="2015-03-04" version="1">MTTILSYLLPLVIYVTPTPEELFSRYNPELQKRSLQNREKTKEEFDHFAMKLRDYAKHDKPIWLVAEDADRKAREARNLKRQPKKDEELAENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC27</accession>
    <name>A0A0B1PC27_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000629">
        <property type="protein sequence ID" value="KHJ34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC27"/>
    <dbReference type="STRING" id="52586.A0A0B1PC27"/>
    <dbReference type="HOGENOM" id="CLU_005947_4_1_1"/>
    <dbReference type="OMA" id="NNHPRDV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="531" mass="60897" checksum="5EF1CF3FC22991FB" modified="2015-03-04" version="1">MVIGAMTQAGLNTVDMSDLNLFQQCLTVVLSMIGNPIVVSIIVVLVRKRAFEKGLKKRRKEEKKRDHTSLTTSIASSIIANLDDYSESRVLNSFVSGVKNIIELIMKSTRHRENQYVDRNAQFHSLSLEEREYVQCVEYRAVKLLGYMITAYYFIWQFFGCLVLGIYLSLNYTEEISREGFNPWWLGASLAIGAFNNSGISLLDTSVIPFRDSSFVLLNMSLLMLAGNTAFPIFLRWILSQILNLIPDNEKCEDLRETLRFILKFPRRVYTNLFSSDQTWCLLALLIFFNAFDWTAFEVFNLYSPDLQTMPTKPILIDGLFQTVSMRSSGFIVIPISSLFIGLQTLYILMMYISAFPITITMRSSNVYEERSLGIYAQELYSSDLPINDESTSGLPIRRRDRFYFVQEQVRRQLSHDLWFLVIGAVMIISTESSNFNRDPQTFSIFNMIFEIVSAYGCVGFSVGLPDKTYSFSGAWHKLSRLILCAIMLRGRHRGLPVDIDKAIQLPGQEMDFAEEQDHRFRAISKMTGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC53</accession>
    <name>A0A0B1PC53_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000091">
        <property type="protein sequence ID" value="KHJ36262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC53"/>
    <dbReference type="STRING" id="52586.A0A0B1PC53"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="541" mass="59808" checksum="956ABFD0C6701A02" modified="2015-03-04" version="1">MTDSMEISQESLAPTADLSHQPSPIPPVPPIPNPPPSIASTSPPSQTTSNNISTGRQILKPAAPSKRPIPDRPHHDSRNNSDIASAFLPQELADIIATRQRRERAWHARLMICTTVISSIDSTLATFTKEVEIEEAVAFKAYLKLAIANFAAVDSSPPPPRVPLHTRPNKGNGNDSSKGKSKVKNLSKIAVALPRIACNQIPNLGSIKEVELPKIFKNNDISWATVARKGQKKARMVQKINMQANRNKESQKVSHRDNSATSVSNKRLFVRLRQDHEWRKLSPAGIREVIVKKLHISPSLIGRIKPIHSGFALSPCSAGAREEILKAENGLFLSGAKLETATNWVSVLVPTVPAFVKMEQGVVEVSKDMLSDEIERVSSMRPAHLKLYDRNNLEAPHRTWLAYFPKAPRGGFRVFDESGVVRPYKKQKPIEFYKRCNGHHPSKNCSRAPSCANCSSTNHTADICMAATKCRNCGGPHRADSRRCLARPTRSGVPTKEQLKTYRQMGEREYNAVQRAKVAEEKAASIDRTEIDLTDSQASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCA9</accession>
    <name>A0A0B1PCA9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dna replication initiation factor cdc45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000083">
        <property type="protein sequence ID" value="KHJ36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCA9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCA9"/>
    <dbReference type="HOGENOM" id="CLU_016461_1_0_1"/>
    <dbReference type="OMA" id="GEADDWC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="146"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="605" mass="69595" checksum="1C134F28230CCF43" modified="2015-03-04" version="1">MGVRHLKTTLESYATRQSLKDFPLVIDGHALAYHIYYICLSARSTATNAFEAQPTYNELSEFVCVWLDTLFQSEVIIEKIFFDGYLPNSKLKTRLSRLELQTLQLQKYYKLNSIPLSSLDVHVKGNLSLFGGQSVPVKLLSCPPLPFLVSAILEALYRSDRYKKITEVVPWEADLYCANYVKKNGGLVLTGDSDLLIHDLGPDGKVAFFKDMKKLPSDLEVSTLIYHPSIIQNGLGLDEHHGLWSLAFELRKCFTARPSTNIIGRARSLKAVNKFYPEYLDFIGEYTIKVTEISPTDEDTSKLLSTKLQTLDPRISEYLLQFPSFKEISRGLSIIEFANQDQHRIFLPFLLDSPIRTSGWEICNAVRELAYGLVNLILPEQQRITRILEYRRQQGKFGGRELQLPHVTSIPEICSKYCEIYLKLKKKLSCFKNHHFWIAFALYQEKEWSHSHGKESVSEWLTSLMGSFTSGFELNKQCHWEVIHLIAQIDASLYSFRILYQITETLIACEFRGYLPPALLELYQLLQTLPKLNNYYDRNSTINFFKAQLTQISAAINMILENSQASLSKIRSSNRVCESAKTEHYPRRKVQSRITNNPYEILNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP4</accession>
    <name>A0A0B1PCP4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sulfate permease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000014">
        <property type="protein sequence ID" value="KHJ36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP4"/>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OMA" id="TRGESMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="578"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="796" mass="87814" checksum="DBDE58BCEFCFDB52" modified="2015-03-04" version="1">MLSKLDRIKNRVLDALGTETNEQNKKFEESFKNTSLFTRQTANFYTEDEPHVANWIRKKTPKSHDLLNYALSVFPFAKWILNYNITWFLGDLVAGITIGAVVVPQGMAYAILAGLPPQYGLYSSFMGVLTYWLFATSKDITIGPIAIMSVLVGMVVSEAKVTNPDVPGHVVASGLSLVTGIIIASIGLLRCGWIIDLIPHVSIAAFTTGSAISIFIGQIPGLLGIKGLGSNNAPYQLLIRIFKNFHKIQLDAAIGLSSLFLLYLIRSMCILAAKKFPSQEKRIFFLSTLRTVLVILLFTMISWLVNRTHRSKPLYSILSTIPSGFSAASVPVINKSIFKLIAGKVPVAIILLMIEHVAVAKIFGSINNYVISPSQEMVAIGVTNILGSFIGGFAATGSFSRTAIGSKAGVRTPFAGVITAIEVLLAILVLPSVFFYIPFSTLSAVIIHSVLDLVTTPSTLYHFWCVSPLEVPIFFTGVIVTIFSSIENGLYTTTCISFLILIIRFVKARGKFLGMVKTHMVTGDSVVGDQIQHFLPSDNNISDFITNSLGGASSRYLFPALDYSDGSNPEVKLQYPKPGIFIFRFSQDLNYLSASHYFNQLTSYIYANTRRTNQNFYVKQGDRPWNDFTQKKPSSNSSEKPTLRAIILDFSAVNYVDFTSIQQLVDVRNQFDLYASPDIVDWHFSNVNNCWTKRALVASGFGYPSNPSVNMHKWKPIFGIAQISNRDGSIQSDSNICKELLAESGNQSSTDCTSELEKINPRMAVVGGLKYPFFHADLMTAWLSANAEVPYDQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCQ1</accession>
    <name>A0A0B1PCQ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative trna methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCQ1"/>
    <dbReference type="HOGENOM" id="CLU_014689_3_1_1"/>
    <dbReference type="OMA" id="GGCKWQH"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="615" mass="69706" checksum="B9F0B0ED0F726CB4" modified="2015-03-04" version="1">MSIILRCARQYSREFTILSFGFIPSKSGNYLRTMMTKDFIKDNETKDLPKRRWRKSDRDNSGSTGQKKRKIKAIKKLDGGFEDILLHDVIDLLKKIRTENDTNQSEIPENTNDAVQKDNIDLIDCSLPKIFTEIQLEVKEISSTGDGLAIDTEHKQQKQQRIYVVPFSTPGDIVKAKVIKHHDNQVDNNNYTTADLISVIKAGPLRDDTRIKCKYFATCSGCQFQMMDYQLQLNHKKKVIESAYRNFSHLPQEMVPVIGDTIGSPLQYGYRTKLTPHFDAPKGYISKADRMRGVKNHFKETPRIGFNAKGANYTMDIEDCPIGTDAVRMGMKRERRNVTENIERYTKGATILLRESTHRLPNNETNIATTIPDTIKTINPDHIDFKSCVTDNRSKTTEYVDQFVFTNIANEFFQNNNSILPKFTQYIRDNILRPLSASTRPRTNQIRHLVDAYSGSGLFTITLSSLFESSLGIDISTASINSAQENARLNNLSSSQAKFMAADASRLFKEITFDPDETAVLIDPSRKGCDDTFISQLLRFGPQRIVYVSCNVHTQARDVGKIINGLSTNSDPKNKESEGSSYILESIIGFDFFPQTSHVESVAILDKLSIEHVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCW5</accession>
    <name>A0A0B1PCW5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000488">
        <property type="protein sequence ID" value="KHJ35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCW5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCW5"/>
    <dbReference type="HOGENOM" id="CLU_025709_4_0_1"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="356"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="476" mass="53612" checksum="A86092405D240368" modified="2015-03-04" version="1">MSFDLLPYLSSLQNNIRSRPIAWEGTVRAGTITNEQLQKIRAVDKVRKEQRKQIIESDLDGYRALFLGADGILSILDAAVKRADVVQYILVLLADLLDGNPAFSKALSQHPSPYKVFTTLLAHSNEPENPIPLLTSTVLTALISESSVEFSSKKTALLDLFRYLSSLTHVSDGSFQDIAVLQYSNLLREKSSRMLFWSQRKQTIDPLIKILRAATGTTNEEVRPPLLPGTTNGRGNIEAIVGGGVGLQLLYHVLLVLWQLSFESETIGVIFQDEYDIIPLYVQLLRLSSKEKITRLIISSLLNLISTNRQNLLPIAVIVRLPTLLQNIIGRHLSDPDVSEDLRNLAMVIDEYTKTQTTFDEYAAEINSGHLQWSPPHKNPIFWAENARKILDYEGGVLPKKLSEIMAKTWENDKQVLAIACNDIGSIVKEVPEKRLQLEKLGLKKRVMELMQESDESVRWESLNALSGWLRYSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY9</accession>
    <name>A0A0B1PCY9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000138">
        <property type="protein sequence ID" value="KHJ36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCY9"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="39529" checksum="10D1DB0998676DE3" modified="2015-03-04" version="1">MSPDTEIQALPTDMRPTPPPVHSAPFPLSPNSPIIVTSDNNCELYTQYSRPILTPAAPSKRTAQSVAEQASQSFEDESDQSYAYLPQDLREIIKQRRLRERAWHVLLSICTSVICNIESTYLVFKDDIEKEEADIIRNYLQQAIARLVASDNAPKFPLIPHHTKLPVTKGSTQEKVIPKKKASTIPLTPLTNHKGPQPRKREKELQSDNNNNKIQQNSWATVTRNGHKKSRIMQSTPIHTAKITILQSRFPARPSNNIKNLNKRKKNKTKKSDSRLFVRLSQEDEWRKLSPAGIREMIVKRLHVSPAFIGLIKPIRSGFALSPCSSEAREELLKASGGLFLSGAKLEPANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD12</accession>
    <name>A0A0B1PD12_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative immunogenic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD12"/>
    <dbReference type="STRING" id="52586.A0A0B1PD12"/>
    <dbReference type="HOGENOM" id="CLU_759095_0_0_1"/>
    <dbReference type="OMA" id="PAGPFKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="39232" checksum="3C4481CAAB3E23A0" modified="2015-03-04" version="1">MSEVAKTQESGPAQVTSEPTTANVEVDKSIPEPTIVEPTIKEQAPADATPAAPAVEEQVTEKAKENEKPEDLARSLLKGFQNKLAGVFPKKAEKISDNKEDKKEAPSDIKEEIKDDTKEVKETKERRSASRKRNSFFGGLVLGKKDEKSESEEAAVIDSSKDVTEPKQSAETNTEQVTDTATGEVPAEKPAGPFKRASIFGTLKNQFARKEKHDVTATAKDSDNVTTTAPVIPAVGTIDIPALEGTVSEAVVEKAQEIQATVEAKAEKITSKADRRKSALPFGLGLSKKEKQVSSDDEANEKPLSPFARIRATVRSRTSPKHAPEKKEELTVPAETNTEKAVSQPLVTEPEPAVTTVTPTVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDF2</accession>
    <name>A0A0B1PDF2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000424">
        <property type="protein sequence ID" value="KHJ35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDF2"/>
    <dbReference type="STRING" id="52586.A0A0B1PDF2"/>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059079" evidence="9">
        <location>
            <begin position="18"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="184"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="61057" checksum="DC08217423E6D043" modified="2015-03-04" version="1">MRSWLYVIACLWLSVGAIQIKLDQTNENRQICAGMYSQKAWGGSVEPYILVNFTKNETGDNPDPIVSLVIFEWKDYDLIGVFPTPDSDIKEYMCDKETIKLNYCMSNQTGEFIMAPNATKLSKNLLYTQAVHLKDPGVPTKYGIKKTGYYCVGATAFQPRDLIFGATVDFRNAYGQLPGSQIAKLPFYGGITIAYVVVGAFWAFLYVQHRHDILPVQNYITAIIIFLIVEMLMTWGFYDYMNRTGSSIGSKVLMVIVAILNAGRNSFSFFLLLIVCMGYGVVKESLGKTMVYVRWLAGAHFFFSLIYAVISLTIAPENAGPLVLLIILPLAGTLTMFYVWTLNSLNYTMRDLAHRKQNVKALMYRRLWWAILGSIIVIFGFFFFNSFTFASRGDPDFVPFHWKTRWFILDGWLNLVYFADVIFIAYLWRPTENNRRFAMSDELAQDDEGFEISDFGVEDDEIESTIGQKEDRDQRPEETRYNPAPKNSGRKTVKNTTRESLERETIFTVGEDGDKCSNNDSDEEHVNLVSGSNKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE80</accession>
    <name>A0A0B1PE80_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000478">
        <property type="protein sequence ID" value="KHJ35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE80"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="27466" checksum="596C71D7F44E14ED" modified="2015-03-04" version="1">MPAVRTKRQFTMADIAKSRAKVRLKNKGLAPDLIDINAFESAINDNDSPGIEMIDEEIDRLIAKGLEASCWANTPTSSSTSSSISVDTPKPADQTKSTPTPPCSARLIIPTSEGPIVIDLSTSQEFSRTPATNTLQEIPVTTVRKLPCPPKLQEVVKAEEHRAAQMAANLEVCSVAINGVEDALAHLTSGTRNDFVVSLKVYLKNAISQFIRSGTSAIPPSLPCRPTGPFPAVPVIKNTARSTPNKPAFIILQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEW0</accession>
    <name>A0A0B1PEW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000380">
        <property type="protein sequence ID" value="KHJ35471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEW0"/>
    <dbReference type="HOGENOM" id="CLU_146824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="12533" checksum="6917C99D8F15190F" modified="2015-03-04" version="1">MPPKSNINARTITAPLAAFCMAAILFVYSRTSILAAKRNAQKHRDADGGQLNWHNESQRRHGKLESPVQDGTLGQLYATIQELQVNKKSTSIQGAKEDSEKADKGGRDRTVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEX5</accession>
    <name>A0A0B1PEX5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc finger transcriptional activator of the zn2cys6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000222">
        <property type="protein sequence ID" value="KHJ35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEX5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEX5"/>
    <dbReference type="HOGENOM" id="CLU_007201_1_0_1"/>
    <dbReference type="OMA" id="DWHPRNL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1031" mass="117169" checksum="38C802994960025A" modified="2015-03-04" version="1">MALTLPPSSDRSDETINNNYSPAAHEPHFSKHKRVYQACIPCRRRKVKCDLGSVDNPDNPPCVRCRRESKECYFSATRRKRKHVNGKGKNDQQYKYQDDYAIRNGRKMVSYQGSSPVQNCQSSTGSSQSFAASNSLFDVSIEQTVKPPLTPGGSIGRSRPLRRPNHDHRASPCAERDRELSTQLENLEAQEVMRQQVYGPYDALDLLYKAATDSNNKHDAEVDHQLPFEFGRITPPSHYQSPTDTGNEYRARQDFSHPLEDRQEKILDPLLSSYEHSGERKKNGTTKPPGYCSAIKAWTRFRFVRAGLFTAAEAIAYIDYYYEYLSPLTPISPPTFRDPATHLTLLTEEPFLAVTLLSIASRYYQIPDPGGHCRSYAIHEQLWTYLRGMIERCLWGQESFGGRYYGSTLETTSFSSIASSRRGLRKGNLRALGTIESLMILTEWHPRALHFPPIDITDELMIPSYDEQENCSSNEEVNSRLHHPTHGIGGKRIKSWLEPAWRSDRMCWMLLSTAMGLSYELGVFDDVETILATSGELSRPEYEEETYRLRATRIKRLLLIYATQLAGRLGWTSMVPENFRSADPSFSPRNPGNMSDLNNSETQINSSENFNYIPDLKLDDQVIHCWAGITNVMRVSNESLFNSRKHTTKIIQDGSYVDLLQKFQPMLRKWKREFERFCLPLYIRHILTIEYEYIRIYIYSLSLQAVVERCTNHGKPYPSDSTNGNPTIRPTISPAVRDYYCKLPLARLGGIRAADQNYIREVVDGSRNLLRTVVEGLLPNNYLKHAPVRTYFRIISGAMFLLKTFALGASKGDVEISIELMHRAVDALRNCIVDDAHLGNQFADLLETLTFHLRGRFVSALAGPVKTESLNHQYASIPLNSNNKIGQSYHHNIDEWNTETMSLLPENCNNDNFNDNIESSADCSVSATPIQSQTNNSCFLTSDRQLDFVGNYSLTNAGEKFQDIDTTTSIPNEWAGQTNEVWYLPPGMAFFENINDQTVAQTSEGVNVGGMDLLDFMALDPLEPYQDISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF30</accession>
    <name>A0A0B1PF30_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000203">
        <property type="protein sequence ID" value="KHJ35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF30"/>
    <dbReference type="STRING" id="52586.A0A0B1PF30"/>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="29004" checksum="DC445D1003B3993D" modified="2015-03-04" version="1">MNHFPQAWGRPRDDIYGPYDGSFLHDSRPNQHTTTPIVTGTSVIAIKFKDGVVIAADNLASYGSLARFTNVKRLRKFAETSVIGFGGDISDMQYLDRALNNLEIKHAYDSSGHSLNAKNLHTYLAKKFYQRRSKLDPLWNHVLVAGLDDEDKPFLASADLYGTTFSSPSLATGFGAHLAQPLLRKLVPDEEAATKLSLESAINAVKESLKVLYYRDARSMDKYSIAVITKDGIELKENEKLENQSWAFAEKIRGYGTQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF58</accession>
    <name>A0A0B1PF58_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative opy2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000469">
        <property type="protein sequence ID" value="KHJ35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF58"/>
    <dbReference type="STRING" id="52586.A0A0B1PF58"/>
    <dbReference type="HOGENOM" id="CLU_1541251_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="174" mass="18848" checksum="3C979BAF63BD26D6" modified="2015-03-04" version="1">MSSQTSVGRNSVASTIYGNNAVISSISAQKGIRGKAAVVSVKSSGTFDGNIPPLPTFDFYNDAAIPSPAFSIGSTFLSRASEATQGKAQVVRVRNNLEDQKYYSPLEIKSQASHPTSYLDQPINLNQGPFSDPFPFDYSSEKYIVSEDSKTTFGSNLKTQSGLDNEMKEVKSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFQ1</accession>
    <name>A0A0B1PFQ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-c-methyl-d-erythritol-cyclodiphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000418">
        <property type="protein sequence ID" value="KHJ35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFQ1"/>
    <dbReference type="HOGENOM" id="CLU_035427_0_0_1"/>
    <dbReference type="OMA" id="FAIEVNP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="304"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="523" mass="58306" checksum="D95B8884FCFF0595" modified="2015-03-04" version="1">MWGSEKDKVAGVEATKYLESKNIPILTNSSRFLKRTKLDLYQTAITSSFFVPGNTPGKFPKFVKYGDGYGGQLSLNTNSAVCVNEEEMKKQISLMREKNNHLKILVQDYIIGNACSVIVIEMGRGVVALDPIQQIFPGPTPNNEAFLNWDEKFENLENGDVRFEFLEDDATISILKSTAIKAFKASDSTRSGWARVDLRIEISSGLVYVIDICSVPMIFYPKGNLLGDDLVISQRFPGGHPAFIDTLLATRQIQLGELGRRNARVAAIYDKNAIHYQTLIQRGDVKFFTFRQALVSMFEFSGTVLDMACGTGYFGELLHQNGIKAEITGIELSTGMLNFPAIKNHYRCPVMVGPMQELIMVANEYDHIVCFGGLHFLDRIHFNAVLARIFMLARKSITFEIDDLNDSYIARTKGKYGELCYNGNNVNAAEAFSTPFGRAHNSNVTTCKHHIEAVLHLLSRLVKLKSSPSRGAGVNAQYTLHIWDSQEDSHNPSLQDSHSSPRVSIVFVSTSLSPQYFLSQSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFS9</accession>
    <name>A0A0B1PFS9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000399">
        <property type="protein sequence ID" value="KHJ35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFS9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFS9"/>
    <dbReference type="HOGENOM" id="CLU_748403_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="370" mass="41767" checksum="5A0530851624DC6A" modified="2015-03-04" version="1">MHRLCAQSVEFKKSSWAATAAKRHNNATINLTQKLPRKPSPPQGQSHEDRRAMVRLNSELEARKTEPFLLQQQIQLMISDPSIVADAIVVLSGVAILAPTPAKAATILEKEVFIEVKPLDVPTNSRIFKTSFVDDIKHRGTEKEYTKSRLVVQMYKDDEKNSVLTQSPNLQRVSQRIILALAAMLPWGYSFGTLSRHMSSQQGIFHEISTFGHCQSLAVMNDPKTSKTLYGIPKAGNYWLYTYHKQHTEILSSIPSTFDPCLLYSSDFDADEFGVYGSLADDRLFLAYQNFADKEKTEIKKAKMNAKDRETLTKGNPLKFNGGLIYLHSNYYPIHNCKTKATLQEFKTSSAASDRHSKFQGETAKDFIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFU5</accession>
    <name>A0A0B1PFU5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 6-ructo-2-kinase pfk26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000388">
        <property type="protein sequence ID" value="KHJ35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFU5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFU5"/>
    <dbReference type="HOGENOM" id="CLU_006383_3_1_1"/>
    <dbReference type="OMA" id="HAYRYNE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="164"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="66543" checksum="C753C65B072FC4BD" modified="2015-03-04" version="1">MISSSSSINGDAFTTSAPGSPKIKPTRQSSGSTTPRVRPPATTLNIPGMTRSKISPDGKISQKDVGAKLVVIMVGLPARGKSYITKKIQRYLSWQQHSTKIFNVGNRRRVVVGSNEPSSSQKTRPIPRNTIIDPPTQAAHILLKGVNPLHMQPKKASRFSLDENHMEQSAEFFDPKNEQASQFRDQVAIATLDELLDFLLLDNGSVGILDATNSTIKRRKALFKQIKDREPKLNILFIESVCQDEKLLEANMHLKLRGPDYRGKDPQKSLADFRKRVAAYGSAYEPLGDYEEDHGMQYIKMIDVGRKIIHFRLQGFLACGIASYLFTFNLSPRQIWITRHGKSVDNTLGKIGGDSDLTEEGEHFATALYNFVDKKRHQWEMNQTKRALNSMNLPQPGDQSPPYPDLLGELETKNFCIWTSMLKRSISTAKEFCDDENYDAKHWEMLNEMHAGSFEGLTDDYIASEYPEEYAKRAMNRLGYIYPGVGGEGYLQVISRLRDMVREIERIKDHVLIIGHRSVCRVLMAYFMDLQREAIADLEIPLGMLFSIEPKPYGIVFHAYKYNEETFDFDEIKDYKYCQRIDSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG13</accession>
    <name>A0A0B1PG13_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sad1 unc domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000104">
        <property type="protein sequence ID" value="KHJ36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG13"/>
    <dbReference type="STRING" id="52586.A0A0B1PG13"/>
    <dbReference type="HOGENOM" id="CLU_006633_1_0_1"/>
    <dbReference type="OMA" id="NALRHES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="132"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="717" mass="79974" checksum="2B05227E56FED6C2" modified="2015-03-04" version="1">MAASEIGGIKEELGNITATVLEITSSVIKEVIQELPLITATEAAQTKESVLGVSQDQSAFLSFEEWRKQTLEKAGQKENNGQKKVTDIKRQESDAYQKNLDTPVGEGTIDLQNSALDSGVKKEETVTRQEDGKTDKTLHVEKIKESYRSKDAGKTCKERFSYASFDAGATVLKTHLGAKNAKNILIENKDSYMLSECSVKNKFIIIELSEDIWIDTVVLANYEFFSSMIRTFRVSVSDRYPVKMDKWKEVGTYEARNSREIQAFLIENPQIWARYVRFEFLDHYGTEYYCPLSLVRVHGTRMLESWKETEAAGESEDEDTDESVSPEEVNAVLSETFSEEKEVNETGATDSEATQIPIAKDFTTSDSNRVAVDKTSWKDPGFYIFNAGHTPPLDGVCSLDDLNSQLIVVDVIETITVNSTNESMSTGNKKLISELSIGSLSSIKDHTKNITLGILNQSSSSITQVSSPALSPSEISRNSHISHGKSSQGNINSHNTSSTSTIPKDKVSTQTTSSSSSLPTIQESFFKAVSRRLTLLESNSTLSLAYISEATSHLHQAFAALSRNITRAQLTKTTVFLDAINSTVLSELRRFSQQYDEIWQSTVISLESQKEDSRRQTLAISERLNILAQEVVWQRRMSMIQSVLLLLCLGIMIFSRVSTSSEQFFLRPRSRVSTNSRQYNDGFSSDPATPFPWLDTPNRTPISQNSPQNPILNNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG87</accession>
    <name>A0A0B1PG87_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000332">
        <property type="protein sequence ID" value="KHJ35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG87"/>
    <dbReference type="HOGENOM" id="CLU_2560000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059615" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="82" mass="9793" checksum="872729436E9DB675" modified="2015-03-04" version="1">MKKKKSNNTVNCYFFLFFISFSLPEKAQADWNHSYKNYKNAQLERSHTNDDNEVDVLYKSIDHEVLDLNMTNTEYSAENTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGA2</accession>
    <name>A0A0B1PGA2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGA2"/>
    <dbReference type="STRING" id="52586.A0A0B1PGA2"/>
    <dbReference type="HOGENOM" id="CLU_007681_1_0_1"/>
    <dbReference type="OMA" id="CWTTRIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="533"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="907" mass="103875" checksum="A42A50BB4DBA4764" modified="2015-03-04" version="1">MVFPLHYRVCYCWRFGQHFLLAGSRVVERQRISRRHSNRQLSRKVEISGSSIVHESVGGLNKAISQKKLLPSLGVYEKNITNCEVNEDFDESPAPRNQLENSHQDHHHLDSSATSEYLNSNSKDAAGLPTKYLYSKSSHLVSQPKSELDSQPDRLVSLFQSNVSLNSKDSSSGLVLEHFNHVDKYRNMIDESKPLSGKLKLYIDNFGPSNPKESLSCVKIDCTTLLQEVVESKRVKPFDPTIPSITEVTRVFSRINSLNEKEWGDMIMALLERISIIQGKSVDDKPLILDIVGAWNAAGFGSKAISPQATSQLYRQFGLDYLIRKIIPKIGYIDLTKAPVAVFVTFDVLTKKYNEIYDQIDKVESLIKTLATVVSIPELDVRMLDLDNQSITIRSYILENWDSMREKARHITELLTKSDEKKLVPKTQEPDKYKYENKYHFILPFNHAQKGSYIYSRLRTAINLKNHAQVDDLWIELSSQFIHRSKEDLEHALQNWLTPEIFNHFITAYMSLQRPTTAIEVWTEMIEIGLNPNLKTWNILISGCKTVGDWRSSEKIWKTLSLSGFSPDLLNWSSRLGVLMNSNEINLGIQALDEMGRIWLEKARTNYPNLAKNDLLLLNDVKDAVKPDISCVNIAIAGLLKKNNKYRANKVLEWAHRFGIKPNTETYNIFLRPLIRKGNSQEAMALLRRMEEAGVEADVSTYTIILDNILRFPEEYSPEELKEKIFGVFYEMEQGNIQPNLYTYGKIIYQLVREFNPQNSSIIEAVLQHMTDQNVKPSIHIYTNLVEYFFLQNPPNLNLAQNILNQATQTVGLDRVFWDRVVECYAQIGDTKSALNIIAQLSTQKTRVGWSAMRCVLDALISQKEWNLAKSLIYDVKTSASRHDFRTGTKGEALFWELAARNNISHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGD4</accession>
    <name>A0A0B1PGD4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 90s preribosome component rrp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000201">
        <property type="protein sequence ID" value="KHJ35936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGD4"/>
    <dbReference type="STRING" id="52586.A0A0B1PGD4"/>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="OMA" id="PDQMKHR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="341"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1200"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138427" checksum="D2597D99CBFC4A08" modified="2015-03-04" version="1">MSLEEKLHKIRSPKLQSQQSTQIVLSAVEDTLREQKTEATPAGYFAALLALLRQAISNTDVNTDLATSVVYLLDVVTPYISQPLLRSKFSQILTSLAPALTLTEAKAPLLRPSIGCLESLLVAQDSASWNLGQAQIGPRRALAGLLVLAVDHRPKVRKRALDAINRVLINPPVSVAVDHPAADMCAETALKKLEDLATKSSVRKRERMIETPEFEPGLIHALNLVKTVAVASGGWPIRKIESLCEVLLSISKTSNHFLSMATFDIFEIIFEGMASAKTSSKLPRLLEVISEMRPSQNDSQLFPPWIAVISRGYSVSAKAHPNDTFQKLPELFNFIAEFLSSSSVAIRVSASECLISFIENCIPKTVILEPSVFEQKVLEKLGKASVELLSLKYQVAWMQIFKILGSMFDVFLWQAENTMLDVTKAVGDLRENSSFSGKNEADYVIGKAIHAIGPEAILKIIPLNILEPKKGQQGRAWILPLLRDNVRNSYLRHFKQVFIPLSEAIYQRVMDHKDSEKTTEIKIFEALVQQIWAIFPGYCDLPLDLVENFDQAFAEIISNLLYTQPELRPDICKALLTLVESNKSVSSIEGPDDLLLQRRVTKVAAQRNLNHLSTFASNMLAVLFNVYSQTLPQYRGYILECINAFLSVTNANDVKDTFDRVCTMLEASLKETQSEKQAQNPPRKNETLPPTSHTLMDLVVVISTYLHEESVQTLLNLASMMLKINSDPPLQKKAYKIIPRLSMSEIGRDVLVKQSYELQQMLISSSDLVCTAAKKDRLAAISALIPYLPSDSLHFIPAILSEVVISCKETNEKARTAAFDLLVLMGEKMASSTNIIIENKKIPHMPDDSPSVSASLEEYFTMVSAGLAGSTPHMQSACVTALTRILYHFYEKLTHETISELVETMDIYLASNNREIVRSVLGFVKVCVISLPISIMQPRLSSLVPNLMVWSHEHKGQFKAKVKHIIERMIRRFGVETVIKFCPSEDRKLISNIRKARERNKRHKAAEAAKLADGEINNLDSEVKPRKKSHFESEYDAAVYSSDSTSNESDNSEDEVKGKNNKDTKYRGKAYIVEDNEEPLDLLDRKALANISSTIPLKQKSHTKSKIKMDVDGKLLLDDNGDTMDLDTPEVAIDEDGTDAYVKAIKGRNAAQRGRGGRLKFSNRRSDIEEVEINVDESNIRSMQNNTQSTTSKSSVNINRGKKINRNPMNKRRGFGESKRSGETLSGRVVKNSKSRKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGP1</accession>
    <name>A0A0B1PGP1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGP1"/>
    <dbReference type="STRING" id="52586.A0A0B1PGP1"/>
    <dbReference type="HOGENOM" id="CLU_004834_0_0_1"/>
    <dbReference type="OMA" id="RWEPRSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="933"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="505"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117924" checksum="4C1C8C4E2394A010" modified="2015-03-04" version="1">MAYNLKEARLKRSQLVNQYAGNLLRLNSPISSTGSCHGTVVSDTTSEFFSEIEEDFANGDIWNSTGNLNTSPKDRRKKNDIDNIRSTTKKHGRWEPRSHLLPIFQTSAIANEFPDFTSLDEATIEGNRNVNSGESISIELARGHKQKPNMASPRYSQSHQELKNASDPHNTSNYLRKPTAEPSKSYVSKDLNSTPRASNKSKSVGTRVISEQKKIARTTVHRSTNITSSNANAVNINKRELRSSHSFQPESDEEVENSILTREQPALFTNATNSTGANTYPSKCFNKISLTKKSSRYNDSRYCVVSDGKSCSKNDNNGNLNDVSNSRVDNYFLNTPSKRTNRNTQMQNKDEQIKFQGNPTQTTTSFLIPWNDNLHLTTSPNNDIPVFTAQGQVQSIRLPHEYIDGIDLPFEEEQIYNMIDNMNGQARKTQDILECIERRKSRLSGGEILLSSTRRSDSGLGESGSEVLGSIAGSALNEHIHKANNENYQGTQTQSQNKTEANPEIQRLSLLNEDLERQLSDTKSANKEAVAENWARIIEIRELTAKVRKIQTEKRRLEQEIVSNKQKLEEKEYINKASCEELKNLRQERERDTANWSSKSQEYESQIKNFRTEINELHRKLARSEKSCKVLKENTEKILESTRILETTKIKRLSKKSSQKENESKIIPTSKLFIKRQTSDHENPVAEPTAPVNDNNNSIDFDISGVSYSDGESLTHSIEKDITETNNFPGLTSSNFSDILGHGFAEKMRNGLESINELVEQQNIDSQTDLGETENITRFENTTQSVNSNPPLNLVTNTSTVTTPRKEFSKRSTLQRTKSLNEKNVTTVFKKSSRCKSTSALREVIPPQDPARSPDINKSTFESKVKVQKKSYSKSETSHIMHSCADHNSMNCSVCIQKISMSSKSAQKTTIRIEKPIPVSDRMPVTEPYEDQPTLRPSTSPGLALARAIKANQDEIEHIKQKYLEAHSSYLSQDASIGKSSRRSLRDLVNSLFIEMENKKDQLYRLYDVLEGQKTAGQEMTSDFLDVTLTNIGIKFDDTWNGCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGR2</accession>
    <name>A0A0B1PGR2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">EV44_g1551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGR2"/>
    <dbReference type="STRING" id="52586.A0A0B1PGR2"/>
    <dbReference type="HOGENOM" id="CLU_044783_1_0_1"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="78"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="29098" checksum="DFC283E147AEA13C" modified="2015-03-04" version="1">MALGKLTTPIQLAPSPLGTKEYWDNLYDEEIANHIQDAKSEGTIWFDDANAVEKILDYLEDFINHPKASENHINRETSSILDLGTGNGHLLFRLRNCNGKSLKRLSWNGQMMGVDYSKKSIEFAQRIAIERKENSIEFKHWDIMNSEPDDILKGSNMKGWDIVLDKGTFDAISLSPETDTNGRRICENYRNRILPLIKTGGILLITSCNWTEMELKSWFHGPGLTYIDKIEYKSFSFGGQTGQKVSSICLLKGQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH59</accession>
    <name>A0A0B1PH59_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000121">
        <property type="protein sequence ID" value="KHJ36176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH59"/>
    <dbReference type="STRING" id="52586.A0A0B1PH59"/>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="57095" checksum="36081CDE4AEAEE56" modified="2015-03-04" version="1">MASFNPTQIFDDGTIEEKGENARLASFVGAIAVSDLVRTTLGPYGGDKILQSASTGEIMVTNDGATILKSIALDNAAAKVLVNIAKVQDDEVGDGTTSVTVLSGELLREAEKLVEKKIHPQTIIEGYRIASKAALTCLEKSAVDHSNNPEAFRKDLISIARTTLSSKVLSQDRDHFAELACEAVLRMKGSSDLSHIQIIKKAGGKLKDSYLDEGFILDKKIGVNQPKRLEKAKILVANTAMDTDKVKIFGARVKVGSTGKLAELEKAEKDKMKAKVEKIKAHGINCFINRQLIYNWPEQLFTDAGIMSIEHADFDGIERLALVTGGEITSTFDHPEQVKLGACDLIEEVIIGEDTLIKFSGVAAGQACTIVLRGATEQLLDEAERSLHDALAVLSQTIKDPRTVLGGGCTEMLMAKAVDVAALKIDGKKQLAVAAFAFALRQLPTIMADNAGYDSSDLVAKLRTAMYDGMTTYGLDLSTPGGGIAEMREMEVIESYKLKRAVVSSASEAAELLLRVDNIIRSAPRKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH71</accession>
    <name>A0A0B1PH71_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000119">
        <property type="protein sequence ID" value="KHJ36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH71"/>
    <dbReference type="HOGENOM" id="CLU_1161882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25682" checksum="05A99E80CBC08615" modified="2015-03-04" version="1">MDINYLLKNNNNNNNLKQRRVQYAGLLDKLPVQQTIQAACKKIKPSAGGRESTHAANRSKDVSEWARICNKETSKRRQKEAGKIEAFEEWRETWTGLHKVRHSTYRTPADPKVWKAATITIDKNTGRKILTDKVPGVANPKCQCGYPAQNVKHMVLGCHQWAEGRGEILRQAKDRPYEAMMNIPDDMARITQWILNKGWYEQFRLAREVDAVLKDNWRRAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIL6</accession>
    <name>A0A0B1PIL6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative csi2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIL6"/>
    <dbReference type="HOGENOM" id="CLU_037244_1_0_1"/>
    <dbReference type="OMA" id="ANAPYMQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059674" evidence="3">
        <location>
            <begin position="25"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="38393" checksum="431290EE9DE7FA8D" modified="2015-03-04" version="1">MLFCRFYLLFKIAFVLLASKSIAAQKDDPGPTSITDSSTSTQDQTTTKTPTSTTSSSTSISTLSETTDTTPTKKAVTSTQTSTPTISVTSTDDGALTNLPTLTGGYTIVPPSVPPTQNAPYMRQSNLPEGTVFIVVGATLGFLALSVLAWRMGVAWCLHRSVRKAAFSQSMSNTKAIYRTIATPSVPNAPLYRYSDRGSSISLSGLGNKGGKTGSKSGTAHSNSNTANLFFSPTAGTSIQNGPKGSSNYLPAGYYSAGSSVPMNTAGQAPFSGPGISLSNLSVQSQGFRRSRSFDPSPPDSPLTRPESNRNHQANASILSLSQTNCGSDLAPSAYLEELFDGENIGPRTHNTSERQHSRGSNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUK5</accession>
    <name>A0A0B1NUK5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative powdery mildew-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005458">
        <property type="protein sequence ID" value="KHJ30052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUK5"/>
    <dbReference type="HOGENOM" id="CLU_1612035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080344" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="165" mass="18570" checksum="1B35FF9DD1A5C3CD" modified="2015-03-04" version="1">MGLNSALMKLALIPLLLSVALATINEDIREFIQVTSNMERMGVRIATSPSHKERSSEPGLLLEIKPSSLILLPEELKLTPVKNLDRGTHRTKLVVLSDNAQDLRLICEKNAAQESFQEWSIVDLCKREIQNIFSKYINDISKKKIHFAIARGDLEDAPVVKLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVL7</accession>
    <name>A0A0B1NVL7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005633">
        <property type="protein sequence ID" value="KHJ30013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVL7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVL7"/>
    <dbReference type="HOGENOM" id="CLU_692978_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="160"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="45480" checksum="5E3116ECA9B3515F" modified="2015-03-04" version="1">MNPIKSNEQTKESKIPKPYTLILKKPIDSAGIDPRNTITGKRTRNKTAKAKELNTNVLLTSFNIFVIGRAKEIENLHRSKLPPPPGNWRELKNHSYSKSFTDAMSVEFDTLFAKKTFEFVEQNSTMTPIPLKGVFTYKFGDAGYLFKFKSRICLLTLILNRKGFVLRLLRALYGLRKSPKLWLKLLSGTLKYIGLQQVSRQPCVFTDYDGISIFFFVDDLVFLFPAIRRPRALELLKKLTATYEFRVLGELDWFLGVKVSRNKSSRKLWLSQESYVEKICKEFDCEVQGRKVNTPILDDRLSKYDSIATSDEVKLYQKKVGLLIHASGVTRPDISRAVSHLAEFMTNPGPQQMDAVDHLLFYTSQTKKLCIEYSGTSTSNILHFSADAAFGNTVERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVP0</accession>
    <name>A0A0B1NVP0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative wd repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004289">
        <property type="protein sequence ID" value="KHJ30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NVP0"/>
    <dbReference type="HOGENOM" id="CLU_004531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1331" mass="150811" checksum="289B4E53FD63C02D" modified="2015-03-04" version="1">MISFNKLFDRIFSSRKIIENAESNEENNGDLKHRISKFEKLVDLIEEDNDNPTVEHNNYTHGDSPIDTSKSVIPNQYEKKSGEGKKETVKLTDIEPRMSRANFEIPMTPKLIANYGNGCRPAERVEERFPMLDNRKRRITDVIEPFQLIKSKRRRLFEPPITPASQPSSTILKLQSLDSSEHKLPLRSSFKPQSFESLRKNCNAPKFTESSGESSLGQTCRNRNSRISSEGQIQKLSRAPDRTRDRLAQLLKVHVFVHVRKALKPFHAELTKKYCKEIGEDAVRIIIENPDFIKHLKSNGNCILPDYEVILAAQACSYINGRARHILGDEIVNKKILYPTQSNIYPNKFLHNSLQSQSSTSISDSASEHEEIFCRQTEKDARLNSFSPSTSLSTDQTDIETIKKPSNSPSHSSIPLRRTTRLANVSNRVYAKPLTRRTSKQLDQNELFIKNDPGHSKLKNFDSPRPYLRYHYRKKLFGQLKKDETEDEPSLHVPFSQVEMNYIIALVKKQTSIPIPVSNNMLQVLTDMMAGRIYLVSKIANSISYRHDDTAMVKALSHRTRSDIMAFLLDALNNTVSEYESTAKSIETPSMEIDTTRAIFNPLNRLLRHREIDGIYPARIRRGQTSYRQVVSSFLGDCLVPQSEWADSSNDIAAISWISNDAFIVGALTHSDPHNMQYNKPGNLLVGSVSQDTLRSYPHHKIERPIVSEFQNLENSLDSMRATQSPWLYTSVVSSAHSIVSGYSFTSSYDNTVKVWKVFDDGSGMRLCATWAHEARVNFVVTSEHHDRVATASGTNRNAVRVYQFYEHAIEKSPYDEYGGNKSQEQSGEVYTHRPWAYQPATIKWARSSCIENLLLVGYSPRADSGDDSDIPDDKKNTGELCIWDSDDGTRLHVSSGRMQNVFDAVWHPTQPVFAVATSPFGNYDNDRTKTQVRIFALNEHTFISIMTLDCPALDITELTLMPNCAIKLYVTASCTDGCTYVWDVALGEDPIHILRHGASIDNPEPNLPLELADDGVTFSAWGADVSRFYTGATDGKLIAWDIRKSPGNAFVRNVLELSGGISCGAFAKDFQRLLIGDSTGKIHLLGIDDSDISEDERISSNSFKSKNIPQNLGSLPLSIKPPKIVIPHPEPLPPKGYTNRNMEKPCEKVCQELLSEGVLRFYPGKGIFQGPKYQNSNLYRAEAHEHEDIRRPLKPEIMSTQQFLKDDKVTSIQIPTLPRVRRSHLAADHKAHLKNINLDFDLSKLTLKTRQELKRDRAELDWNDAHSFEYELTPRSTIFTKETKSRRDLMGSGLKGKNIRTSHRASVSTDEMDELAIKFMNDICKRSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVZ9</accession>
    <name>A0A0B1NVZ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003988">
        <property type="protein sequence ID" value="KHJ30557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVZ9"/>
    <dbReference type="STRING" id="52586.A0A0B1NVZ9"/>
    <dbReference type="HOGENOM" id="CLU_019222_0_0_1"/>
    <dbReference type="OMA" id="HNRHLNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052109">
        <property type="entry name" value="SRRM_Domain-Containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34755">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="707" mass="81823" checksum="F30EAB1D45CFBA7D" modified="2015-03-04" version="1">MSTVAGRLRAGRRTRAKPIISYAESSESENEIDDKYLELEYSPRLKPLTRSRSLFLQSQRRETLLRVKSQEFESYPAPKKRRQISNPELKISTRKTECQTESGVIPAWQNLPYHIFVQIFRFASYPLYDERTFQPLPSGSWLLKIARMCRAFAEPALTVLNYSPPLIPMIKAHRLVDLFKTDPTSLAFKYRQKVVSLQIEVNQVAAYTLTGCGHLDLYSLVRNLPRLLDLEFYHQKDMIPFRDLKAPIKWVYPESVFEALEYIDPAADSQWGDKTKICRLRSWRWSSRLAGKKWPLYRLSEVHMRPSFRSLRKIAFINYQKPSIKNDEKDPNYENILAESLKYLPNIEHLIFESSTLFNSKLLPLLPNNLRHLEVINCLEINSNNFADFLITHGQQLRNLILNYNQSLNLAFLTVLGSSCPHLETLRMNMTFFNIQKRYQCSEPLFDNLLLSQQVPVWPKKLQVIELSHLRKWNLDAAEVFFTSLIDYAADLSDLRRLSIQAIINGGWRDRASFRDKWVGLLNRVFKRNPKPPEPVYSIRSTAVKQSSPEIKKSFSTNETIHEDCSPRKSQIAVEQKELKNTSVRRSQRSATRAVCAGKYAESMNYGLRELNILRETGGIDLSSKSPYSLESLSEESNALNKKRPDHKVNPVIQGMCDSVEIRIDNLRPIENQITEADFIDEEISGDEDWNSDEDQGESANEDINTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX66</accession>
    <name>A0A0B1NX66_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003388">
        <property type="protein sequence ID" value="KHJ30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX66"/>
    <dbReference type="STRING" id="52586.A0A0B1NX66"/>
    <dbReference type="HOGENOM" id="CLU_702223_0_0_1"/>
    <dbReference type="OMA" id="REHWLKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="47884" checksum="BCBC372035AC3027" modified="2015-03-04" version="1">MSAISRFYESAKSLLLNQPQNQENTKIISTPTSPNEYARTNTNYSNVIMSKELDDIVSEARVQPSNSLEIHKKRSRVNSLEENKPLVGLSSKKQKILPLREKNSDILVTPKSRMIKNLQKKKKIESEALDLPNSIGSDSNNNEGSQAHHSIIRTPVNQDGTESHDATPFYTARHYRFGSEDDLEKQLQSSALANTSSIYINSHESDDESEDDSPEIIMAQESKLVAELKIKDINKALVARNSKTQKKKKLKQKLKKKKLNYDKVENELKITSDSNTTDKTVKMKEGEKDLTDFIPNNSTNSIQSSMDKPRLNLLKNSNNSLPDLLPMEYLEDNDETLQATNIRSKSKPPTKLGKKILFNEKQVKDRRVGNTTYRVLKSNSQSLAPRASYDARRIKEMWLQGRNGRIQELNKHSFSKSSYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXT7</accession>
    <name>A0A0B1NXT7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative minichromosome loss protein 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003645">
        <property type="protein sequence ID" value="KHJ30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXT7"/>
    <dbReference type="STRING" id="52586.A0A0B1NXT7"/>
    <dbReference type="HOGENOM" id="CLU_004219_2_1_1"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="8">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="417"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="725"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="834" mass="94741" checksum="894A230C81816608" modified="2015-03-04" version="1">MTTVAQFRPRARPAHTRGLTHLSYTPDGTRLITVGSNNTTRVYKTGFDGEPTNIDDCPDQNTAVASTNDFFVVGSEDGSISRYSLETMLFEKYLTRCSLPIRDVDLSMDGVWCAVASDEIAVKIVKTDDIRSVKFLREHTKPVKHLSFDPAGKLIALSCTDGIVYIYSLSSDPPDLVRKIDGLIRNVETEDDICSKVAWCPDGRAFAAPTATRSIQVVSSGDWKNQKAFSNGHDGDILAISWSKNGAMLASASKDRKIVLWETRDQKVIATYPFASVIDLAWHPTRNLLSFTNMEGEVYIYNDFVPPEYSHLVDLSLQTSPFIHDPLAENQSKIQRLSKIHKDLPNRGVRLGSHDSLNDILDAGVMGQDDDDFISDDDGAGYALGLNENRKRPISDFDSLGGIVKHRIKSWEPQYHESFQPGSTPWRGGRKYLCLNLIGFVWTVDQDTHNTVTVEFYDHEFHRDFHFTDTFLYDKACLNENGTLFSCPAQEESPASIFYRPHETWTTRTDWRVKLPKDEEVISISLSDSYITVTTSTNYVRIYTLFGIPFRIYRQKSCPSVTCASWKDFILLLGNGPVDAYGHTKLLYTIQNVKQDEICQNEDVVALPNGVTLKSVFFSENGDPFIYDSNGILLTLLHWRTPSQAQWVPLLDTRLLPRLASGLKTESYFPVAVSNNKFHCIILKGTELYPYFPRPLLSEFDFQVPLISPSEIKDDNTKEDDDLKRLEHDFILKNIIISQQRDLIENAKTSREQKLTLQRIRLELDKTLLKMINHECRESEDRSMRALEIVTLFQDKTGKMIEAAMKIAERYDRTTLSDKIRDISQMMLADISED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYF1</accession>
    <name>A0A0B1NYF1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dna repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005371">
        <property type="protein sequence ID" value="KHJ30065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYF1"/>
    <dbReference type="STRING" id="52586.A0A0B1NYF1"/>
    <dbReference type="HOGENOM" id="CLU_006598_1_0_1"/>
    <dbReference type="OMA" id="ACRHISR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="634" mass="71201" checksum="03DE98F05C5374A6" modified="2015-03-04" version="1">MNMNDLDIEMKIKISYLHSVQEFTWSSTNRRSARQIRGPQSALTDFLASHNISAHQIREDAIARRAAAVAANNSQSVDEPSSSTATANTAAVEGGIENKEEKLRRKNKESTAIASIKASKSLKRRHKAKVSDHELSGEDSDAINFINRMDPVPQQMTNCEICRKRFLVTFYSRSCPETQGKGLLCSKCSSSIERDKRAEKKRKPQKLGTTRRQNASNILDGVYLHSGTKNLVSLCVETLANNVQQAESFGSLSFDLVRRLGDILSKRRLITSPILDLFLEQKHDSLIITDGAKLNSDDYCRIFQLVPSIKHLKLRNAIQFKNKVMDFLLGTTVNLISLDLHGANLIDDERWDNFLRKKATHLRTLKVHFTDSYFGDRAIELLPKFCPELQRLKISHNLKVSDAGLEPIALLTNLDHLSLELYRPMGFEPLSPIPLIKIIESIGSRLHTFSVESVINIDDSLLVAIHQNCRKLNKLRITDGERLTDDGFTLLFNNWSNPPLSFIDFSKCRHLDAVCPRKNLRNIGLCSLGFEAMMSHSGATIRDLNVSSCRHISAQSFETVFGAEKLYPDLEQMDISFCQTVNDFIVGCIFRSCPKLRILTVFGCFGVKDVKVPKGRVLIGPPNAVGMKIEGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYH8</accession>
    <name>A0A0B1NYH8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sam domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005207">
        <property type="protein sequence ID" value="KHJ30090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYH8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYH8"/>
    <dbReference type="HOGENOM" id="CLU_021546_0_0_1"/>
    <dbReference type="OMA" id="DWTAEEC"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="385"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="490" mass="54017" checksum="614828BD8488FADF" modified="2015-03-04" version="1">MAFESGTAFADSDGDEEYERSVRSSLVIATDSEASPTDSEGLFSNDHTPTTYDTHISGDKLPETIITQWTADECADFVSSLGLHQYGDQFLENEIVGEALVALQHDELKQMGVTSVGHRLTILKSVYDIKVRQEIPIENDHYIPLSAEAESQSAAATLKDIKLLVEQLHLRDERMTAAESELRRITFEYTRLREDLLPVFRMAKEGKPLPYPSAKTNGSNSSNFDNSSNISSPASSSPAIQPGISRNYSTKKFFIDHPKNLSPTYAHSAHERSLLEQTLDQSAASDRNLQSYSNLPSISNSNSSLPSPNQLSPTSPLQPCSGSTLGSRSYRSDQSIPSRSNFGQLDGDQNQGISQGRDNTKSAPSRRVQATTIDNSSSGGSVEIFKSFRVSMDDPCYKVLPAALKKYNINAPWEQYALYIVYGDNERCLNMDEKPLILFKQLDKEGKKPMFMLRKIAPSSEQQVDSGNAGLDRMSSRQQGGYNDPPGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZA4</accession>
    <name>A0A0B1NZA4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002628">
        <property type="protein sequence ID" value="KHJ31722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZA4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZA4"/>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="10">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="9">
        <location>
            <begin position="322"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="519" mass="59052" checksum="931275089DE510F2" modified="2015-03-04" version="1">MDLDASIPLYSHYGYIEKNNATILCCECGAAIDGTLSTGALCNECIKLTVDISQGIQREATLHSCKDCERWLLPPSSWVVAAPESRELLALCLKKLRGLHKVRITDASFIWTEPHSKRIKTKLTIQDSVSDGVVLQQTFEVEYIIASQQCPDCAKSYTANIWRACVQVRQKVSHKRTFLYLEQLILKHDAHRDTINIKEVKDGLDFFFSARNQAEKFVDFLNSVTPVRTKKSQELISMDIHTSTKSYKFTYSVELVPICKDDLVALPIRLAKQSGNIAPLGICYRVGSTINIIDPSTLQTADISSPIYWRAPFTPLADIQELTEFIVMDIEPIGAQRGRWLLAEATISRASDFGVNNQTYYTRTHLGNIVHPGDSVMGYLLNGTNFNSSQYDALEQSNVYSSLIPDVILVKKLYARKKKSKSRNWRLKRLSRDQGDLLPKKVDQDKIDRDYENFLRDVEEDTELRQTLALYKARQSKRDREAINEMDLDDEDDDVDELPGINMNELLEDFDELDVNDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZY9</accession>
    <name>A0A0B1NZY9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative zinc finger transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g3192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003893">
        <property type="protein sequence ID" value="KHJ30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZY9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZY9"/>
    <dbReference type="HOGENOM" id="CLU_289056_0_0_1"/>
    <dbReference type="OMA" id="NIEGQVY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121050" checksum="FBB2A95046B4C17C" modified="2015-03-04" version="1">MSSGLPLTNFPTCNVINYTNTKNRGAYVERQSNKFLHQENISSTEKTQLGLAVLNDQQINVLNNPQYSNFTINNFHNISEPRVLSEVNINNNSILNNNFNNTTSSLVLDYQNNFNLDHSQRGPESPFPHLQGLENSFQNVEDSFVTGTTNIAQVQFMNGTTNCNQLLHTRASSEESNNIVGPSTPGIRLELYKEKYSLNAGVTIDENNSRVKVKEHKLDSIPAWSELKTKAGKERKRLPLACVACRRKKIRCSGEKPACKHCLRSKVPCVYKVTTRKPTPRTDYMALLDKRIKRMEERIFKIIPRENYDTNNNNCYSGPRSIVKPKIYRTPARNIAGRKRLTEEAFEEELGVWTQATPEPSIKEIKQRKNNILGIKSIGNELMTEGANELPTEELQKHLAEVFFENIEGQVYHLLHKPSFMERMRSNSIPPVLVLAICAISARFSTHPIIKKSPYHLRGEKWAAVSRSIVIRRYEYPDVTIVICLLILSLHESGTCQRERNWSLGGMAIRMALALDLHQDLDHDPMNADHEKKLGFIDRESRKRIMWACFAMDRLESSGRNRPPFISENIINLQLPIKEKYFIQGIPGQTEYLNESIGYISSSKVDEISDTKSNMDVSAYLLRVIAIWGRVSQYVYSSLYPHHESTSQGLESLFQSLDQQLATFHETLPENLKYNMENLSIHNTEGLANQFILLHIYLQQNILFLNRFALLDGGRKDLESRAFKEANAKKVAKSFAAADEISRLLENGNSYFISAPFVGYCAFFAGIVHILGIFSEDLSRKEISKTNLIINMNYLSRGKKHWMILKSMHEYLQDQWTICSDTNHSSKEIESSPIMSFQYSDLLDLYCNDTNMFNSSEETADFKKEITGDEKIDSKVASYRVEREGSHYTIKPFQNIGLYNSTRKSKKSPPAPLITNSTMSGNFGTKLNPQCVLQNYGQISPITPVNIYDQQHFHNPSYLFPEFQQVNLPQSDRTPDFDSFCCVDLESNVHHMSGTSPTWGTTQIIEGGSVDSRILNQSSGFNGPWLLPYSMDSVDLDHEQDIFPPMHESDTISSKWQDISNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZZ1</accession>
    <name>A0A0B1NZZ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002796">
        <property type="protein sequence ID" value="KHJ31553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZZ1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZZ1"/>
    <dbReference type="HOGENOM" id="CLU_002055_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="98" mass="11460" checksum="A0C030F9A76C41CE" modified="2015-03-04" version="1">MKRKIPLVICIDNYSLYECLVKLGTTKEKRLMIDIAAIRQAYERREISQVIWIKGKSNPADAMTKSQYSDQALDDILSNKYFIDKEAWVERNTIENSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZZ8</accession>
    <name>A0A0B1NZZ8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004732">
        <property type="protein sequence ID" value="KHJ30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZZ8"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20715" checksum="6298CE6384C8D0A5" modified="2015-03-04" version="1">MVRAHGKTRAGAPHRFWLAHFPREQAPRPGFLLFDESGVVVLYKPRKSIQQCGRCLGFHTTRGCPRAPACENCSSTMNFINECKAPTKCRNCGSSHRSDNRNFLARPSRSGPVSKDQLRTIRKMGQREYHAKARAKTAGIRAEVAATSIEILPSTDRNNLHSINPTNEMVMSEAPIEGNIISETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P066</accession>
    <name>A0A0B1P066_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative iswi chromatin-remodeling complex atpase isw2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002392">
        <property type="protein sequence ID" value="KHJ32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P066"/>
    <dbReference type="STRING" id="52586.A0A0B1P066"/>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OMA" id="PNIFTDW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="144"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="625"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="786"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="916" mass="104175" checksum="CD99E6F267171A33" modified="2015-03-04" version="1">MSPSQAASVPFFLTPEEEEEYGTADNLILNDPKQEALIKEEQKARLENEKGEQRRQKLAAKKKKENHETRAEREAKAKQLDNLLASCAKFSEILTKKTEVLGRVGSGFDQKALGEHDLELAKQPACMVGGTMRDYQLEGLTWMFEICLQGMSGILADEMGLGKTIQTISLLAKFREDANYLGPHLIIAPLSTLSNWEEEFKKWVPSIPFALYHGTPSERKIIYEKKLQKNFIGGRVSEKFPVVLSTPEIVIKDASSLSKIHWEIIIIDEGHRLKNSDSKFFRILRSFTSVTRFLITGTPLQNNLKELWSLLNFLLPNIFVNWEQFESWFDFSDLQDEEGTQEFLQDRIKQDLVQKIHLILQPLLLRRIKADVEHLLPRKREYILYAPLTKQQTDLYNVISNTTADTRKYLVDTVIKQLTVNFQAKSLSSEIVLEDSTDENLQIQENSRIKIKTNKREKSSITQNSKNAFQQMMSNQLTKSNGTITKKRKAQEKIIPPPAKVNKSNKNSTPNTSLTQRKTKRKINYSESQLSEEDALSDDEFEAKLIKEMATSQFPPSSEQGKEDTEMSKMAELAKREIGNKKLGNPVMQLRLTCNSPHNFYNLRALNPDQKIDESIVTSSGKMLLLDRLLPELFKRGSKVLIFSQFKTQLDILEDYANDLRNWNVCRIDGSVNQEERRQQIKKFNEDTSYRIFLLSTRAGGQGINLASADTVILFDSDWNPQQDLQAQDRAHRIGQKNPVIIYRLATRGTVEEDLLLSADAKRRLEKLVIKKGDYKSMVRTTATSTSSVKKDGLTNNDNYTASNQDDDDDNTSKSVSGSSLSEDTLKNLLLKDGLVYQYKSGDEILSTADLEILCDRSPEAYDRAASGLSDCSNYCVVETKPDAFISCISNSSNINNQNNKNHFSNTSKSDNEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0F7</accession>
    <name>A0A0B1P0F7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003646">
        <property type="protein sequence ID" value="KHJ30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P0F7"/>
    <dbReference type="HOGENOM" id="CLU_001832_4_0_1"/>
    <dbReference type="OMA" id="LFRVCNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="431"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="610"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="853"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1393" mass="157538" checksum="C72A1444213AC8D7" modified="2015-03-04" version="1">MGKKGGRQNNTKPRNAVEVNKKKLPEELPDNNFIVFVDPKKDSNPRKQVAAAGSANQDTHIIHGDAPKRPDVKKLIGGNSWTGKLPVNILSEHCQKQRWEKPEYTMSKVSEGYSSMVILKARNPKTKELEVLPPFKLPTTHKHLAIKPSALEARHFAATYGLFRVCSMRNIHMMLPPNFRDLWKGEFGSLKNEDIKQGRSWMYEADPFAVMREHIEAKVAVDPKRSDLEKSKVNAHFSRGTTDASPRSLNSDAIAHHVPRVWVEAPKIEMGKKTRSKIEDLVRKYTTWNPNGKKLSKSQQNLTIDEFKKLGFRQSHIEEAISECKDREESLEWLLIHIPEDDLPAWALPEGYLAGVSMASSDLKKECAIKRLAEPGYSIDLCKQIFGKMTDEALAAELLQKILISNNYESTDAKPNFTEEKKLSSQAIWEEEISSLHAVLGNRFKKLGKDLCEIQLSPEPEKNITAMKVIMRLRKSQNYPFHAPIISICADLPAYIRLSITKQTLIYLTENLLGEQMLYFSIDWVEQNLHRIVEKPGKLRDISTVTSATDGAPPMKLRRQQLPKYTLTPDPTPNDKSRDDWVRRQSHPKYKSQIEKRRTLPAWELRQTIIDSISLHQVTIISGETGSGKSTQCAQFILDDRYEKNLGECTQIICTQPRRISAISLADRVSEERCSAVGQEVGYIIRGESKISQKTKIKFVTTGVLLRKLQNSGGSLDDVVASTVDISHIIIDEVHERSLDTDFLLVLLRDMMRKRKDLKLILMSATLDAGIFEKYFQKLGKVGKIEISGRTYPVEDYYLDDIIRLMRPEIGTEIKDEEKKQEKSDELDLNIGGIISDLPMRINYDLITELVKEIDAELSCLKQNYGILIFVPGVSEINKVLDYLRHIPNLHALPLHASLQSIEQRKVFPHAPPGKRKVIVSTNIAETSITIDDIVAVIDTGRVKETSYDAKNQVQRLQEIWASRAACKQRRGRAGRVRAGKCYKIYTRNVEMNKMPERPEPEIKRVPLEQLCLSVRAMGIQEVNKFLANALTPPENSAIDGAIKILRRIGALDGDELTALGLHLSMIPADLRCGKLMVYGAMFGCLDACVTIAAILTTKSPFISPFHEKNEMGLARVKFAQNHGDLIGDLRAFDEWTKMINDRSIRQQEIQKWCFENFLSFQNLNDISSNKLQLLTSLSELSFIPSSSNGKEAMSYLNRHNSNISLIRSLCAGAFNPQVARISFPEQKFAPSYSGTVALDHEAKTIKYFNEENGRVFIHPSSTLFRAQSFPGHSNYIAYFRKLATSKIFIRDLTPFNAYSALLFSGPITLSTTKLSQGGRGIIVDGWLYLRGWARIGVLISRLRRILDDFLARKIDQPELFSSFSSPDNSSSSDVNEVIDVVIKLVEFNGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P151</accession>
    <name>A0A0B1P151_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative atp-dependent rna helicase dbp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003991">
        <property type="protein sequence ID" value="KHJ30554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P151"/>
    <dbReference type="STRING" id="52586.A0A0B1P151"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OMA" id="GMPYPKQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="199"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="404" mass="44887" checksum="2D2771B91B07DEFA" modified="2015-03-04" version="1">MCIPEILKGRDCIGGSRTGSGKTVAFAVPILQKWANDLTGIFALVLTPTRELALQIYEQFKALSSPHQLKAVLITGGSDMRPQAIALAQRPHIVIATPGRLADHIRTSGEDTICALRRVQIVVLDEADRLLACENAGSMLPDVEECLSVLPPTSQRQTLLFTATVTPEVRMLKDLPQSPGKLPLFICEVDIQSLAVPVTLKQMYLTIPITHREHYLHVLLLTSANISKSIIIFCNRTTTADVLTHLLRLLEHRVTALHSRLSQRQRIDNLGRFRASAARILVATDVAARGLDIPEVELVINYDVPRDPNDYIHRVGRTARAGRNGEAVTLVGQRDVKLLQALEARVGSQLEEWKEEGVNLETRVIREALKLVSEKKREAMLEIEEGREVGGKRKRNVKISTKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F3</accession>
    <name>A0A0B1P1F3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003685">
        <property type="protein sequence ID" value="KHJ30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1F3"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="16306" checksum="B474A81B1F3CE98B" modified="2015-03-04" version="1">MRNTWKPIKLVKLDIESLRIVVFSDSSFANNRDCSSQIGYIIVLIDKYNKANIIHWSSIKCKRVTKSVLASELYGMTHGFDAGGALKSTLEAILSRPIPLVLAIDSKSLYDCLVKLGTTKEKRLMVDIMIVRQSYERREIADII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1K1</accession>
    <name>A0A0B1P1K1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002021">
        <property type="protein sequence ID" value="KHJ32512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1K1"/>
    <dbReference type="HOGENOM" id="CLU_1103462_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="28718" checksum="A14AF2FB1B813390" modified="2015-03-04" version="1">MNSVTEIATVYCRMCKKNCSPELFANPASNSSYATCLDCRTQDHNRRYPTVFDPIPTQRSSDNLEDIDEANDEEVEQLAANIGMFEIVEEEVFNGPIPEEAPLGDDSIFKLSQLQSTEFRNHDEIQRRLQADEEANGINNPDEAPQVENFIVSEIDPNFDPFLEELPPNMFDNDNQVENLVPNDPFVEENLQTRNNEVLQSQDHLQIDPFLELNPPPQAEDMTMNNNQLPAEIGEAIEARKFKTFFSNATNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1V6</accession>
    <name>A0A0B1P1V6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003035">
        <property type="protein sequence ID" value="KHJ31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1V6"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OMA" id="IMIFIPH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="534" mass="59811" checksum="D5EEBB2316402671" modified="2015-03-04" version="1">MLKIFEKNLLHKKGSDDRYNEVIIVMDQSNRDALRNEINADRIPRRHRCQYEYDIKSIVINKAIQDVGMGRYNWNLFFLCGIGWLSDNLWLQQVALTLPSLSNEFNISNKDVRYTTCYLFVGLCLGTIFWGIGSDIIGRRVSFNLTLIIAGLSGIAVGLSSSWLSVCLFYLVVGFGVGGNLPVESALFLEILPHESGRYLTLLSIWWPIGQLIASFSAWCFMGDNRNPKKGWRYSCCVLGTLTCIMFIGRFFFFHLFESPKYLLSRGRQAEAVAVVHGIAYRNKTKTWLTEDILNEFGGHFEPNQRHSLPVRDIIHRKISNYSVKRCIRLFETREIAKNTTLLWFCWFAIGLGYPLFNDFLPQYLSSLHDSSGEQIKVYRNYVIITIASIPGSILACYTVDVQGIGRKGTMAVSTFMAGILLIVFVFSPLHLVQVGISAVQGFFQNAMYAVLFTYTPESFPAPIRCTGSGISGFLNRIGGLSAIIIAANIPATSSQDGVILDAKVPAIISGTFMVAAFLAMLCLSVETRGEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P203</accession>
    <name>A0A0B1P203_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003428">
        <property type="protein sequence ID" value="KHJ30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P203"/>
    <dbReference type="STRING" id="52586.A0A0B1P203"/>
    <dbReference type="HOGENOM" id="CLU_1262351_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="24657" checksum="5A51C32A63AFC0C6" modified="2015-03-04" version="1">MILTKPDIAFILGRLSQFMKDPAVHYGIALKGLLHYLRSTVKQKLRFGLGAEAEYISQAPYAKQGQWIAQILRDLRMPKIIDKNGLTVQMYGDNQGALALVKYPHLHERSKHIDVSHHFIRELAEKRKLIIDYIPTSEMTADGLISLSKELLLKDLRFNLGIKNAVNEKNASVKGTHIVAPQFEQSPPMIMNIDTESESDHETESEADKFPSLPSAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P210</accession>
    <name>A0A0B1P210_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001864">
        <property type="protein sequence ID" value="KHJ32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P210"/>
    <dbReference type="STRING" id="52586.A0A0B1P210"/>
    <dbReference type="HOGENOM" id="CLU_103610_0_0_1"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="18342" checksum="D4E6C929C8FEE3F1" modified="2015-03-04" version="1">MGHPAGLRAGTRYAFSRKFREKGMIRLSTYLQQFKVGDIVDIKANGAVQKGMPHKVYHGKTGVIYNVTKNAVGVIIYKKVKHRYIEKRVNLRIEHVSLSRSREEFVKRVKANAELKKKSKEEGTIVHLKRQPLQPRESRTISMKDNVPETVVPIAYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2L4</accession>
    <name>A0A0B1P2L4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0404</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003490">
        <property type="protein sequence ID" value="KHJ30884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2L4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2L4"/>
    <dbReference type="HOGENOM" id="CLU_027506_3_0_1"/>
    <dbReference type="OMA" id="WYIMFGR"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059311" description="chitinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="16">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="371" mass="39803" checksum="F9D6B15A30B2476B" modified="2015-03-04" version="1">MFLSRIIFFVALMHPPCSIAQTFSACNPLHATNCPPDAALGKAINIDFTNGPVDSFTASGTPKYDANGVHLSVTKSGDAPQLNSLFYIMFGKVSITMKTAPGVGIVSSLVLQSDTLDEIDMEWLGARSSDMQSNYFGKGDTTTYDRGAFHAVPNHQNRFNTYTVEWTSSQIAWSINGKIVRILTPSTAAENQYPQTPMQVKFGAWSGGDPVNSPGTISWAGGPTDYSKGPFTMTVKSISVTDYSTGTQYKYGDQSGSWNSISSVGGEIDGNSGEIHSQVIPTNMPSVTTLSPSIPAGLGKNRDSTSTRTQWPWVATSTTSAISHVATYVNGLPSGWVITSSGKVIPANSAVVNSPRLIKITFIVNFIWLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T6</accession>
    <name>A0A0B1P2T6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative basic proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001959">
        <property type="protein sequence ID" value="KHJ32598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T6"/>
    <dbReference type="HOGENOM" id="CLU_350976_0_0_1"/>
    <dbReference type="OMA" id="SGRNQMI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058838" evidence="3">
        <location>
            <begin position="22"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="802" mass="84412" checksum="3BF37DB9A0AC4F4C" modified="2015-03-04" version="1">MHTIFFLFCCLALICSTPIKAEDERPNILFPRPIDLALSDTYSNPKINVLISKDEDETPSLSESQYSSATIVVQEDHEPQSSLQNPVESALTNGQDVDEQDLEKTWAKWEDITENLKNEGTTKNSDLVNINSTTPYTLTNSAESQEPTNFPNYQAPPTSYESILFTGFSSMATSAQSTLDIPSNSASVKSSDDMIQSTAIASLSPGNVKSESSVRPTLISTSDPVTIAQSSALTSSVTQSISSVLENEYSSSSKPLFTGSGSATTLIPELSGSVASSAPYPGSGLNSSPSNSTVLSTTSYEPTSTLSFESTSTLSFESTPTLSFESTSIKDISSSYNFYTKTTSNPVSSVTNATQTIVTTSYSLTLTSTGLHPLPTNGSASTQSSTDSNIFTSGTAIYSSLTSSLLTTTSNGTATSTPGFSTITIPLLTSTPYQSSSLTHNTTYTSIPPSNYTLTYSNLPSSTPTSIKTSTLSTTPTIIIPTATNTASTFIPSSIIAQTSSTHSSGQSTQTVATGIPSALPKIVQNPLGSSTPAQPEDTSEVQIGFEWALNYPFVVSHPLSTTQIFMYLPIGIADGLGLKPEQIVVKNLLPLDTTADLHFITTVARVFIPSSMVDTLRVDLGIAASPIYQNPDESVNTLMNYINPAIPFFPGAVLDLGATSTGTRSKTTQNASPGDAGVFNTATQQTQSASAKGTTAGIALAACGGAAAYGAAMFLLARRYKHRQQRLNRPDSMGCPYETGEGSPTAASSVHPDDNGPLMSGGRFSPTTHDRHSRGSGRTGHATRNAQISAPMMAENSLGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X6</accession>
    <name>A0A0B1P2X6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g4614</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01003333">
        <property type="protein sequence ID" value="KHJ31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X6"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="223"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="507" mass="58145" checksum="77393ECFF6A59712" modified="2015-03-04" version="1">MDLTTEILQALSCVGGPLLSSEAFPNYSFTDLKSALDRLIARSMILYETIEKEEYTLEDEALAIEANGSHEARVFKALRESVEGLTIQELENIVGDKNTVKIGQGKAFRSKWIAKGKENRLVATVDSIEDSTRSQLQIIKKTRTYPDPKIITDLKKRKLIKIQKVVIFRIQKGPKFALELVKEETDLTADMLASGTWKTATFKPYNFRSLGIDQHAGALHPLNKVRHEFRQIFFEMGFEEMPTNRFVETGFWNFDALFVPQQHPARDLQDTFYISDPSEAEKPHAENSNDQSDYEKYWENVRQVHQDGKFGSIGYRYPWIEKESLRLVLRTHTTAISTAMLFKLASTSRPGEKPLPARYFSIDRVFRNETVDATHLAEFHQVEGVIADYGLSLGALMEFMEIFFKKMGIEDLKFKPAYNPYTEPSMEIFSFHKGLNKLVEIGNSGMFRPEMLESMGLPKDMCVFGWGLSLERPTMIKYKVNNIRELLGHKVDLSFIEKNPAVRMDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P343</accession>
    <name>A0A0B1P343_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002998">
        <property type="protein sequence ID" value="KHJ31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P343"/>
    <dbReference type="STRING" id="52586.A0A0B1P343"/>
    <dbReference type="HOGENOM" id="CLU_006308_0_2_1"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="351"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="768" mass="88229" checksum="AC5275CFFB486B52" modified="2015-03-04" version="1">MEITKPKAEDEKVAAAKAEYEKLLNMRSGGTYIPPARLRALQSQITDKKSKEYQRMAWEALKKSINGLINKVNVSNIKHIVPELFNENLIRGRGLFCRSIMKAQAASLPFTPIYAAMAAIVNTKLPNVGELLLKRLIMHFKKGFKRNDKAVCLSATTFIAHLCNQQVANEVVAAQILLLLLHKPTDDSVEIAVGLTREVGQHLEEMNQVIALAVFDQFRNILHEADIDKRVQYMIEVLFQIRKDKYKDNPALKEELDLVEEEDQITHVVSLDDNIDVSEGLNIFKFDPDWEDNEEQYNRTKAEIFGEVSDEEDDEQDDDSDASEEEEEDDDDKQKEKAMEIKDQSNADLIALRKTIYLTIMSSIDPEECCHKLIKVQLPDGMEPELPSMIIECCSQEKTYSKFYGLVGEQFAKINRLWNQLFEESFAKYYDTIHRYETNKLRNIARFFGHLLSSDSIGWHVLSIVHLNEEETTASSRIFIKILFEDLVEAMGFPKLQGRLSDDTLRPYFQGIFPKDNPRNTRFSINYFTSIKMGQLTEEMREHLANLPKPTLPVVPARTEESGSESSSVSSYSSYTSSRSSSRSHSSKRRPSPSPSPSPSLSPSPSLSPSPSLSPTPSPNYRNKRYRGRRRTRSRSISDPPPHRRSYNYSRSISPSFRGRRRSSFSRSPISRGRARKDSYSRPPPRRQQRRRSSSDSRSPPRKSHRRSYTDSRSISPAFRNRRGSSFSRSPVSRGRARKDSYSRSPRRHKRRRSPSDSRSPQKQSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L6</accession>
    <name>A0A0B1P3L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001780">
        <property type="protein sequence ID" value="KHJ32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L6"/>
    <dbReference type="HOGENOM" id="CLU_026017_0_0_1"/>
    <dbReference type="OMA" id="MRFFMRA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="502" mass="56601" checksum="78264849EE4A14E2" modified="2015-03-04" version="1">MPKPKVYLKETKKKKTKYISTALNSADEYLAAAVEFEEAGEKWRGGDAAKSMRFFNRAIECYNEGLEKYQDSYDLAYNKSRVQFELTQHPKLLRLLPKTPLEHLEIALQSSKLALALSPDNPDILFNTAQILTSISEELGGLSHPSFPNPLQVLEEALGLFQSCIQMQELAVLSFREQTAAMASLPDSMDLDSDNQDISNASIKHDSCVNESEYSVVQDDRWATIIEPVTDETILDTTLASLECLTTYIQLVSSDYPHEIKKAEEYMQSFIQKLNIDLIENDRKTEACIIKAGLICAYATAQFFSSRIDFETYLQTINDAYTEIDLSSNPRGLCDFAESLIAYNKALHLHVPETTYQILVTRWKALTKAQEYLTSSSKISSYENLEKIHLTRGDVELLRFQLGQEEISLDIARENSLILLKNAEKYYRGSSKIAKNIGADTIILEANIKEGLAIALTGDLLKIKELNLDLNHNLTKSIFQDVVEDGIVTIDQLKKLGYEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M5</accession>
    <name>A0A0B1P3M5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002796">
        <property type="protein sequence ID" value="KHJ31551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3M5"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="OMA" id="XRLARIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="225" mass="25546" checksum="FE6D8CA98A8E9883" modified="2015-03-04" version="1">MFAAVCTRPDIAFHLGRLSQQLQDPVERHDSGIKEIGRYLSSTIKQKIRFGPPSTHTVVNRISDPSSSLKLYSDADWAYMEVRKSISRYAAILNGGPVSWGRLWLAQALRDMGFLEYVGKDHRLVDMRADNQGAIALVRNPHLHERSKHIDIFYHFIRDIEAQKLLHMTSEPTGQMIADGFTKPLDKTMFQKFKAMMGFSGENYLIEVQSEFSRSLMAVLNGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M6</accession>
    <name>A0A0B1P3M6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3M6"/>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="OMA" id="IGGHAMS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="100"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="100"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="25180" checksum="77C169A35B026696" modified="2015-03-04" version="1">MFTGIVETMGVVSELKLSGGETGTTLTIDDASEILTDCRLGDSINVNGTCLTVTWNDATSFKVGVAPETLRRTNLGGLKAGSRVNLERAVAGHTRMGGHFVQGHVDTIATIESIIPDGEALIFRFKPRDPRIMKYIVEKGYIALDGASLTVTKVDDREGFWEVMLISYTQEKVVTAAKKVGDDVNVEVDQIGKYVEKMVEGYFLEGTNGAPVTFRKVVEKIVDEKLQNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Z5</accession>
    <name>A0A0B1P3Z5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative solute carrier family 35 member e3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001461">
        <property type="protein sequence ID" value="KHJ33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Z5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Z5"/>
    <dbReference type="HOGENOM" id="CLU_048347_3_0_1"/>
    <dbReference type="OMA" id="WMVVNTL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="76"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="378" mass="41208" checksum="96D3DD356FF821E3" modified="2015-03-04" version="1">MADRDVEDGSSATCGIKTYHLSEKNISGTVGRDGSSALTTDGKKVVDESEREGLLHETFEEKSTIINSDTPLKVAIVWMVVNTLATIGIVFTNKAIFSDSSLRLTQLTFAAFHFFITWLTLFTLSRSQFAMFTPKKGAVKDIFPLAIAMALNVILPNLSLAFSTVTFYQVARILLTPTVAIMNYILYKATLPRKAILALVPACLGVGMVSYYDSKPSSDVNVKTTSSLGIIFACAGIFASSLYTIWISSYHKKLNMNSMQLLYNQAPLAAFLLLYVIPFVDTFPTWTEVPVNRWLLIMMSGLFASLINMSQFFIIAQTGPVSSTVVGHVKTCSIVAIGWSISGRAVSDKALIGVIIALGGIITYSIVMLKNRSQLGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P422</accession>
    <name>A0A0B1P422_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative meiotic expression up-regulated protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002935">
        <property type="protein sequence ID" value="KHJ31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P422"/>
    <dbReference type="STRING" id="52586.A0A0B1P422"/>
    <dbReference type="HOGENOM" id="CLU_046464_0_2_1"/>
    <dbReference type="OMA" id="NRWLGKG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="350" mass="40244" checksum="EB990B02558B905D" modified="2015-03-04" version="1">MHRTYSMRQSRTPTASQLQNPPPPTSSTKSGRLFGKGGIGHALRRQAAGQFGPDLAKKLSQLVKMEKNVMRSMELVSRERMEVAQQVSIWGEACDEDVSDITDKLGVLIYEIGELEDQYIDRYDQYRVTIKSIRNIELSVQPSRERKQKITDHITQLKYKDSNSSKIMVLEQELVRAEAESLVAEAQLSNITREKLKSAFAYQFDALREHCEKVALIAGYGKHLLELIDDSPVTPGEVRPRYDGYEASKAIIKDCEDTLTNWVQDQAKVDVKLSSRAQSLSLMRRNNMRNFIERQDLTSQDLPMDHYTWERISNQRSDMYEDQFEDVEEARVERQSEKTGEDKRSETIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A1</accession>
    <name>A0A0B1P4A1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nad dependent epimerase dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002623">
        <property type="protein sequence ID" value="KHJ31736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4A1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4A1"/>
    <dbReference type="HOGENOM" id="CLU_055718_0_0_1"/>
    <dbReference type="OMA" id="TIRMENR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="33289" checksum="0784AB92A9C45962" modified="2015-03-04" version="1">MANKPTFLIWGAHGWIAGQLKTLLESQGKEVYGTTVRMENRESVMAELDKYKPTHVLNVAGSTGRPNVDWCEDNKEETIRNNVIGTINLSDCCFLKKIHVTVFATGCIYVYDHLHPIGGPGFLESDKANFDGSFYSETKAHVEEILKNYSNTLILRLRMPVSDDLHPRNFVTKISKYDRVVDIPNSNTVLYELLPASILLAEHNEVGVYNFTNPGAISHNEVLSLFKKYVRPDFTWQNFSLEEESKVIKAGRSNCKLDTNKLVNKLREYNYEIREVHEAYEACFQRMAAAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4I6</accession>
    <name>A0A0B1P4I6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 40s ribosomal protein s17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002749">
        <property type="protein sequence ID" value="KHJ31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4I6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4I6"/>
    <dbReference type="HOGENOM" id="CLU_112958_0_1_1"/>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="146" mass="16879" checksum="C5D1ED3AFE1F67AD" modified="2015-03-04" version="1">MGRVRTKTVKRSAKVIIERYYPKLTLDFETNKRICDEIAIIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDLYVPEVSALDFSQTESGQLEVDSETKDLLKSLGFDSIPVSVIPVTQQQTVERGVRRYGDRPIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4J8</accession>
    <name>A0A0B1P4J8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative c6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002556">
        <property type="protein sequence ID" value="KHJ31821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4J8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4J8"/>
    <dbReference type="HOGENOM" id="CLU_024934_6_0_1"/>
    <dbReference type="OMA" id="EPCIYDR"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="419" mass="47666" checksum="539151140840D9FA" modified="2015-03-04" version="1">MDLQGSQTGSSNTSTDATATGGLRAVAKNKFPRLYHNKSRTGCQRCRARRVKCSETHPVCTNCSRHGVDCVYDRGVRLANQSINSSSKSSQRRANNSRLRTENSQTYNLLTDSLQVATAGLPENRSRRLLELRLLHNYIENTCHGLLSCNDLSVYRTWQFDIPRMALKQESLLHGIFSISSLQLLRLTPDDLDLRKAQEFYFSAARATTDVDNGYISKENADAIWFAQVLFQINLFASLEGRILEPYVPPLQWLEAIQGHRNMLSPPPNLSKLFRTNAVMVILSNPDLTDHDQIFSALNRQSLSGLMALDRHEEMWDLEAQRAYERTLSYIGSIRKASLEGEHNLVMAGRIVGFPLFAPFKFIKFVEKQHPRALAMLACFFHLASKHTENIWWMGSTPLREFQAIQRLLPSEWHSLITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4K4</accession>
    <name>A0A0B1P4K4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative te1b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002546">
        <property type="protein sequence ID" value="KHJ31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4K4"/>
    <dbReference type="HOGENOM" id="CLU_2607806_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="79" mass="9124" checksum="3C5A8361BA737B59" modified="2015-03-04" version="1">MSCVQRACRQLPQADIAHSLIALAYSKRLGIKTLEVNRFKLWLRQISSFEICAFSDGSTTRQSQYSFKYVCSPSWLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4L1</accession>
    <name>A0A0B1P4L1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative homocysteine s-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4L1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4L1"/>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_1"/>
    <dbReference type="OMA" id="CHIAFVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="453" mass="51079" checksum="B944E8BE3F3ED3B4" modified="2015-03-04" version="1">MTSLPPIYFLDGGLGTTLVDKFGCKFDDSTPLWSSQLLLSPSGNRVLQKCHIAFVEAGADLITSATYQASTREFINFLNKGEESKCNRNSSHVDKDYADTERSKEGKEPNEILQLAPDALENNRKVELEEQDHKFRKNSMATVQAHRKMRNAIKLARSSFGGKQGKVVLGLGAAGACLKPSQEYTGNYAGSEFGTSISSIRKWHFERLSVFIYDKEEDFFDKLVTADNNLGNFKKSSYYNCWNDIDLVGFETLPLLQEIIAVREAMAEVHEYSTRNYLSNILATPASDTSTARVSSKEVARKDFWISCVFPNEEYNLPDGSSITEVLRSMLCVREKAETPMGVGINCTSVRKLEGLIQNYENAITEMISKGEIENWPSLFVYPDGTNGEIYNTETHNWETKKVSNFNSSSWDEMMYDIVKRAQHRAAWKSIYAGGCCKTTPDDIKKLRSRWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4T9</accession>
    <name>A0A0B1P4T9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002657">
        <property type="protein sequence ID" value="KHJ31689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4T9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4T9"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="ICLREAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="454" mass="51695" checksum="5D39F8450E07D5A4" modified="2015-03-04" version="1">MASLKKRFVDDIKHRGTEKEYAKSRLVVQMYKDDQKNSVLTQSPTLQRVSQRIILALAAMLPCDLFLRDITQAYVQSTTNLSRDIYVRPPPELGSHEIILKLQKPLYGVPEAGNHWLYTYYKHLTEKLSLIPSTFDPCLLCSSDSDADEFGVVGLQTDDTLFLANQKFADKEENEIKKAKLIAKDRKPSLKNLKLVQPHPTDILNSRGKLRKASSTHDQFVAQRARGAYIASVCQPEASFDLSFAAQAVRLNNTDINSLNKRLKWQLENSERGLRYVELDKSSIELVVFTDSSFANNKDFSSQIGFVVVLKDKENRANILHLSSTKCKRVTRSVLATELYALVNRFDSATTIKSTLERILCMQLPLIICTDSKSLYDCLVKLGTTRENRLMIDVICLREAYEKREIAEIRWIKGQSNPADDITKSKCCNALRNLIDTNSIFIETNEWVERSSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P513</accession>
    <name>A0A0B1P513_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative copper resistance-associated p-type atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g3081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001491">
        <property type="protein sequence ID" value="KHJ33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P513"/>
    <dbReference type="STRING" id="52586.A0A0B1P513"/>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="OMA" id="DVIRVPH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1097" mass="121002" checksum="BAAF08CC3A8FEE4F" modified="2015-03-04" version="1">MLSEIITSSLLISNLDRPCISKIQNTLAKLLPPPISVSSSIISSMVIIRHRKSLELWKICIALEDAGFHVRDLNFEPQTSIPSRNMEKFMNKSLCAKIDNLATRQDESSSKNREYRDDYLSGRRINAHFKTRNEKSGTNRAHEFEDSFSHLSEDLWRASLAVSGMTCTACTAAIEQKLGNKPWIKKHIINPITNSVIVEFFDEAKKDQIINAIEEIGYKAVIVAVDHVTTLATENQSQQRIVQINVEGIVSDQFPGLILNSLSSFNGISEIKPTIRGNQLSLIITYTPHHSSLTIREILTSIATVHPAIRTSIHHPPTLEERSQKIQAREQFRILIRAIITLAIAIPTMIIGIIYMNFVSKYNQARIFLMEPVRAGISRVQWGLFILSTPVYFFCADVFHKRAYKEILSMWHPISSLSILQRFYSFGSMNTLMSIGTSIAYFSSIAQLISAGVHPQVINDNDLFYFDSVVFLTLFLLVGRFLEIYSKAKAGNAVSLLANLRPTKAHLMGSLSELDNNPNDIPVDHLEIGDLVKVLCGESPPFDGFIVNGETSFNESSLTGESRVIKKKVGDKVFSGTINKFSPITVRITSTLGTTMLDEIIKIVREGQTKRAPIERIADRLTKFFVPMICLIAIITWFFWLGIVMSKKLPAELLDSSIESRISWSLQFAIAVVVIACPCGLALAAPTALYVGSSIAAKNGILAKGGGEALEKAAKLEHIVFDKTGTLTIGGDPEVTNYRILSDGESERRLILSITNAIEIHSNHIIAKAILAFCARHNFERMGTSCIVEISGKGMKGKVLMRSMGYQEVIVGNEALLYDYGVEIDASSQSLIGKWKLEGQSIALTATRTFYKESMLEQEYKKNNWKLVALFGISDPIRPEAFDVIKALRERGIGVWMLSGDNQITTNVVGSHIGIRVENIIAGVLPGQKAEKIKFLQQSLKSSDISLGRQNRSFIAMVGDGINDSPALTAADVGIAIGSGSNIAISSAEIVLVTSDLHSLVTLIELSKFIFLRIKLNFGWALIYNLVALPVAAGALFPLTKKGTHLRLDPVWASLAMATSSISVICSSLLMRSRLPGLGYRSSQISSSESNESMITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P588</accession>
    <name>A0A0B1P588_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low affinity iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002332">
        <property type="protein sequence ID" value="KHJ32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P588"/>
    <dbReference type="STRING" id="52586.A0A0B1P588"/>
    <dbReference type="HOGENOM" id="CLU_028340_0_0_1"/>
    <dbReference type="OMA" id="WQVVMQD"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="510" mass="58184" checksum="474052B6AED0165B" modified="2015-03-04" version="1">MTLLNIWKSVKRSTFPERTPIFATAHTQNLTEEEVQKARYLIPLESEKDSFFDYQELSKASDTSSFREPNAFDKITIFAGSSATFFVILGFVGIWGFIGALYGPTDTWQIMFQNASSIQVYIMDILLIRQQQNSSRAMITRLAEFSSRYTTLKRLLSRIPKNQEALISKQESRLLKINSDQIDEILDQSAFVPMEKSSRITYYWVQACQVIARSLGSLYTFFLYWIGIGIWMILGPSLKFSDTWQLYINTATALALTFTSVFLQNIQQREEEKHSRFLEQALKIDSQIEKRLRLLTGDQKPNSIFSIPEPERTRTERINDFLADVMGSGLGVLISLTFVAVWISIGPTLKFNDNWWLIIGSFTGLVGFVDGFVLRSLYYREERFVKERFLSMATEDQLLFDQIEVSATTPEEPKRSFTDTVSLAISNGCGHRYAPPGAIAVVVALLITATVMSWSITGQLLCNTPTMIIEGFLLIVLIHAHNYANNERRADFTGLLIRRLHLLGFVEMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5B7</accession>
    <name>A0A0B1P5B7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001178">
        <property type="protein sequence ID" value="KHJ33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5B7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5B7"/>
    <dbReference type="HOGENOM" id="CLU_091428_0_0_1"/>
    <dbReference type="OMA" id="AKAWWDS"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="22986" checksum="1D755BA92A785D3F" modified="2015-03-04" version="1">MVFLSNTDDHEKPADPYKAANLDECVSIKDKVRDLSKFVDSCKFGIMTTRDSSSGALFSRCMVVAAKEVDGVDLIFFTNTETGKVNHIKSDPHVNVSFLDSSGQWASFAGETSIITESGIVAKYYSSMLKAWIGDLGDGKHDGSPNDPRLGIIKVRSRTITYAITSNNAITRGFKVAQGAVTGNSPAIHKLREISEKEILTWRSSKEMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5B9</accession>
    <name>A0A0B1P5B9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001412">
        <property type="protein sequence ID" value="KHJ33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5B9"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="35027" checksum="868176E571733E75" modified="2015-03-04" version="1">MAPSTRDKKSGVSETLDSKSRVQKSVNNAGRVHSIAAVLTRSAAKTNAVVEKIAAVQDTHAVATQLEQSSTLAMNIDAESEPESESESELELESKADGFPLLPSTPLLKRTYESSSLLDSIYSKANNQAEDLPQQNSNLMKKARGLLNLVGPYLEEMEIDCPGAGAGFLALISEGVSCAIRGEEIFPKTSKCTDNMPSSPKFKKSSWAATAANGHNNTVINLTQRLTRRPSPPQGQSHEDRRVMVRLNSEHEARKTEPFLLRQQIQRMIPGPSLVADAIVVPSGVAILAPTPAKAATILQYKEIIAQRFGNAVVERQEFCFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5C4</accession>
    <name>A0A0B1P5C4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001995">
        <property type="protein sequence ID" value="KHJ32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5C4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5C4"/>
    <dbReference type="HOGENOM" id="CLU_039466_0_1_1"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="220" mass="25492" checksum="99932ABE998E70F4" modified="2015-03-04" version="1">MENHRADEKRFLDERGSTGPLAPNGLNPATIMEKPVRERIVDCYFWKDQCFAVNEADVVNRVVQSVNFIGGTYGDSQRPSPFLCLAFKLLQLSPSDEILQEYLQYGGEKFKYLRALALFYIRLTRQPKNIYEILEPYLSDYRKLRKRSRIGTSLTYMDVFVDDLLTKDRVCGTTLWKIPKRTVLEDLELLELRVSPLGDIENLLESDDEVVENTVTQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5D3</accession>
    <name>A0A0B1P5D3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative enth domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002297">
        <property type="protein sequence ID" value="KHJ32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5D3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5D3"/>
    <dbReference type="HOGENOM" id="CLU_012678_0_0_1"/>
    <dbReference type="OMA" id="STEFYDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="563" mass="63416" checksum="347D1A0F782DFDF4" modified="2015-03-04" version="1">MSKVIRSVKNVTKGYSNVQVKVRNATSNDPWGPTGQEMSQIAQMTFNNINDFYEIMDMLDKRLNDKGKNWRHVLKALKVLDYCLHEGSEVVVTWAHKNIYIIKTLREFQYIDEDGRDVGQNVRVSAKELTSLILDEERLRTERSDRRNWKSRVTGIEEFGPSQDESMRRTRSQRLQRADEEDAEYRLAIEASKYQEEEDRKRRESQRDFPEDEDLAKAIKLSKEEEEQRRRELEEQNALSLFDDDLIQVSQPTGFNQGYQQQTQVDWAGNPIGPSIPQQTGYLGNMYTGFSPQQTGFQPEPAIYQNDYQNLPISQSTTFDPFGQHNLQPQLTSYNPYTQQNPNNFLQPNQTEALIPGTNNPWATTNQNTNQSALKPTPTGSNNPFASSFNRPQSSITPTKPTLLALQEKQSPSFNSTTYNPIRSFSPPAMPTQPSKDLNPHHSKLNALLATGEGLDTFGNTGDMRIPAQHTAPGTFVNSAGAGLTRLTASKTGNNPFLQTQYTGMPSTKHLGNFPSGFETAQHQVPALTGPASMTAGYRNQSNNVFGTRTQQSNSGQGDLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5H6</accession>
    <name>A0A0B1P5H6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1102</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01001965">
        <property type="protein sequence ID" value="KHJ32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5H6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5H6"/>
    <dbReference type="HOGENOM" id="CLU_023995_0_2_1"/>
    <dbReference type="OMA" id="WIKNWTL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035356">
        <property type="term" value="P:intracellular triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27495" checksum="EA1A552E42E42016" modified="2015-03-04" version="1">MPTRKYIFGYHPHGIISMGAFAAFCTEALDFSRLFPGIKNTLLTLDSNFRIPFYRDYALAMGLASVSRESCENLLSKGGLNNEGMGRAITIVVGGARESLDAQPGTMRLTLKARKGFIKLAIRTGADLVPVLGFGENDLYDQIHPVKYPKIHRLQLLFKAILGFTIPLFHARGIFNYDVGWMPYRKPLNIVVGRPILVRQNLNPDTEEIDRVHKQYIQELERMWEAWKDKAAPNRKEELICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5I1</accession>
    <name>A0A0B1P5I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002485">
        <property type="protein sequence ID" value="KHJ31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P5I1"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="QYWSDQS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1227"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1267"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1301"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="125"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="821"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1444" mass="162454" checksum="F166507A629CB487" modified="2015-03-04" version="1">METTQEKIWRENPSGFSRTHGRGIDVAASEAEFSDLERRLSSPSWISHTAASVRTSISEDTENGYSGNTTISPHFNLEETLRGTKLVAEKSGIRPKHIGVVWENLSVYGTSGQNNYVKTFIDAITSFFNIYATAKSIFGLGYKAEEAEILKSFRGVAKPGEMVLVLGRPGSGCTTFLKVITNQRSGFTRINGEVLYGPFSSKTFAAQYRGETVYNQEDDIHIPTLTVGQTLGFAIDLKTPGKRPAGISKAKFKEEVIATLLKMFNIEHTKNTMVGDNFIRGVSGGERKRVSIAEMLTTSATVCAWDNSTRGLDASTALEYIKSLRIMTNICKTTTFVSLYQASEKIYKQFDKVLVIDSGQEVFFGPAQEARTYFESLGFKEKPRMTTPDFLTGCTDEFEREYTDLYLRENLPHTPDTLSAAFNQSTFAQDLDFEIAQYKQQLEEDVKTYTNFQIAVKDSKMRGTSENSVYCAPFYLQVLTLLRRSFLVKWQDKFTLAVSWITSIVIAVVLGSVWLNLPTTSASAFRRGGLLFIALLFPMFQAFTELAVTMMGRPVVNKHKAFAFYRPSALWLAHLIVDMAFSAAKILVFCIIVYFMTGLVLEAGAFFTFYGTILIAYLAISLFFRSIGFMCPDFDYAIKFTVTFIMLFIITTGYLIQNQSQHIWFKWIYYVNAIGLAFTTIMINEFRRLILTCSSESLVPSGPGYNNIKNQVCTLPGSIPGLTEVYGSDYLRQGYSYKSEDIWKIFGLLILITIVFLISYLILGEAITWGAGGNTARVFQKPNRERDKLNMALKEKREKRRMTKSDVANENDINIETNAILTWEDLCYDVPTPSGKLRLLNNIFGYVEPGSLTALMGASGAGKTTLLDVIAARKTVGVISGEILVDGLKPGGSFQRQTSYAEQQDLCEPTQTVREALRFSADLRQPFDTSQCEKYAYVEEILSLLEMEDIADAIIGEPNTGLSVEQRKRVTIGIELAAKPELLLFLDEPTSGLDSQSAFNIVRFLRKLARAGQAILCTIHQPNAALFENFDRLLLLQRGGRTAYFGEIGIDASVLRTYFEKNGAICPSDANVAEWMLEVMDPSRNGGKDWSEIWSKSPELACVKENISQIKSRRLQAAEKSFKIEEKEFATPLYHQLKVVIARTNLSYWRSSNYGFTRLFNHAIIGLVNGLAYMNLDTSQQSLQYRIFLIFQVSVLPFLILNQVEIKYSISRMIYYREASAKMYSQFAFALSLVVAEIPYSLLCVLAFFLPLYFIPGLSKTPSSAGYQFAIVMVTEFFSVSLGQLLAALTPSPFISSLLDPFIMIAFALFCGVTIPKLQIPKYWRWLYELDPITRLVGGMIVTELHELPVNCHTSELRSFNAPADQNCGEYMEKYFQNGGVGYLVDNMTQLCQYCHYRVGDQFYNGLGLQYNNRWRDLGIFLAMVGSNLILLLIASRFLNFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R7</accession>
    <name>A0A0B1P5R7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bzip transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001089">
        <property type="protein sequence ID" value="KHJ34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R7"/>
    <dbReference type="HOGENOM" id="CLU_1134266_0_0_1"/>
    <dbReference type="OMA" id="NEVNWIP"/>
    <dbReference type="OrthoDB" id="3535998at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="245" mass="27509" checksum="12751F830711764B" modified="2015-03-04" version="1">MSSTSSSSPAPDIVGEPKKKTSGSKRSVTHLSKAQLARKRANDREAQRNIRQRTKEHIGNLERKVKELEQSGRSSSVERVLKRNQDLEAEIERLRAQLTSQAHLPNTSQISPDMLEDLLMSQKNEVNWIPSTSSWNSSEIPNISNNSYPSSEAPSYTHTSFEDEQSQNLYTSNASPVWNEQAVYGSTTGQPISKSSQTWPPYQNSYPSSSRFSSPVPSQNSNYGDAVIWRCMEHSNDLKSRLMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6F3</accession>
    <name>A0A0B1P6F3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative homocitrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002226">
        <property type="protein sequence ID" value="KHJ32244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6F3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6F3"/>
    <dbReference type="HOGENOM" id="CLU_047019_1_1_1"/>
    <dbReference type="OMA" id="KRYSAQF"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="300" mass="35490" checksum="C25F943DD2057A01" modified="2015-03-04" version="1">MPLHLLGKKSWNVYNKANIDKVRQDEAIAKAAEEAEEERMQALDAERRMQILRGEKPIAIPLDSPSSCISKYHQSDRSELSHRERKLRKKANENDTEFEMRVACQKFKEAKANRDKLSLTSSLIPHIASEQINVQRKNPEAEREALEKQREFEDQYTMRFSNAAGFKKSPGELPWYSKCEGSTIRDDKYKVCSKDVWGKDDPGRLQRENMRIMSNDPLVMMKAGASKVRELEREKKKMRGREKQRKYIEREGKKSHKRSRDLKEYENNDIVFESLDYPRIEHKRKKRDNTENHQYRSRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Q6</accession>
    <name>A0A0B1P6Q6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Catalase</fullName>
            <ecNumber evidence="3 12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6084</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Q6"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Q6"/>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_1"/>
    <dbReference type="OMA" id="TTHMQQW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="659" mass="74808" checksum="F11F6C4BC71695AB" modified="2015-03-04" version="1">MKFDHERIPERVVHARGTGAFGNFRLYESAKEFTFAKVLTETSRTTPVFVRFSTVLGSRGSADTVRDVRGFAIKFYTEEGNWDIVGNNIPVFFIQDAMKFPDIIHAGKPEPDTEVPQAQSAHNNFWDFQFLHSEATHMFMWALSDRAIPRSFRMMQGFGVNTYTLINAAGNRSFVKFHFTPTLGVHSLVWDEALKICGQDPDFHRKDLYTAINKGVFPKWKFGIQICPESRQDDFDFDILDATKVWSEELLPIRYIGELELNKNVDEFFTETEQVAFCTQHIVPGIGFSDDPLLQGRNFSYFDTQLSRLGVNWQELPINRPICPIMNNHRDGQGRHSIHKGKFNYWPNRESIVTPTPIPEGAYVDYPEKITAIKQRLHSRKFSEHFNQAQLFYNSLSEIEKTHLIAAAGFELDHCDDPIVYENMVSRLTCIDLNLAQAVAEKVGAPTPIKATRPNHGEKSKGLSQLCFTTEAMGLPPTIASRTIAIIVGDGFSFEHYSIVKKALIEEKAFVYTIGPKRQHITALNGEKITSDHHFEAMRSTLFDSLYIPGGDHIEELIKKGRVIHWVREAFGHCKAIGATGEGIELIQKSFHLPGIELSRDADVIDFFGVVTAKYLDSSEGPLKMIKGEKSFLNVYGYNISQHRNFERELCGLTSMIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z2</accession>
    <name>A0A0B1P6Z2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative structural subunit of the nuclear pore complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002086">
        <property type="protein sequence ID" value="KHJ32429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P6Z2"/>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1651" mass="187127" checksum="13ACD04B5DCD343D" modified="2015-03-04" version="1">MEEFTDLESLQALYADLLAFSEHRLSSIERLGAQLDMHMKDFQNLLDKKARNETSRKKLATGQIEIFGNEYKVNEEFQREAQQLADELDLDELDAAQIFFVAQADITSLGQPALTNSLVLFHQRRKCLLDCLQIICMLTADVELDEVLREDLQATLGQIVSPRASSKKYTQRCISHLSDIRCWLQRLNDKLNGASIVGKLNPETLEAVEYQRVSLIKQHESLCTILFYLIKENHCDVKDFHSILDILRKADKYDNLLVHHIPALSACISRFGGSDTVSAFAEASALHDKIVDQSNDHSSWTLTFVRAAFHVFWLSEYSSWFIESADENSFNQQTQDSLETKQRSKLFVEALKDGAFDFILSISADVKSAEWYDPARHGLRQWLQRKSPVILADTIPFSNIFINILMEQLEAFIESFIANLPDVLRKLRIDEDEQRQLSKDHDHDLDLERFIVIISYTFEGRPKAALEGFWDVPDGALLGFVHWVSRRASTPLVSAFCEMLQSISEDEECATAAHHFLLDDGVPVSGKMRRTHSITWTQIFKELTYFSNKIRDNPVPLQPLSFRPFQGNLLEAEPESVMMLECYLRLITKLCCNSETARSFFIYNSTFNLIELLLQLASSAVGSRLRANAFTTLRSLLSNKTREFSDYIWNSLDSWVSGTHSPGSTMLRSVTSVRFMSKGSILQSLASGFEEPNAFIQLLYALVLLSTDEPRFRNNLPFPENLGVANRQPGITLYIDFVIGEVFSYPSREIDNLDVIQRRLLNLTCLDFISVCLETFNENLIIFGSQGYISISNSIQASSLENYILLHPFSRVMEWIFNQKVMNTLFAIVNQDPAEVARAEPNSPLVLCLLRGISVMILVLDLQATYLEIIRPLIKSHSEYRRLPFSSSSFGSFEEGILNHLTIIPTLGRYFGTGHPELVILSLKLLEKFASSMKLASAPREMLRGSGRNRILAALIDDSDTISNILLKEMEVEIDINQGPLSPAYIIKLEILNLIISCLRASPNNPSIAHLLLGFRCGNEGLFIEPNSSFNKSISLFHTILNMIISLPIADDINLIPWLVTLQHKALKVLKELWITPISSDITITELRAHDFFFHTFAKEQVIQPIMTWDGINTRDPNFPASSGVICFSEFLGRRAILFEYYSTELIQISKTYSPSTNQRILNILMGSNKVEDEQAIDYANIFDFFDFINFQIIPLGPPPMIPWLIDLDILACLDIQDSPEISYDTAKLEEFLLLKVSEVIKVNHIEHEQDLVTLNSQVQELIAYYTKENRLKMLTTYRYQALKAWVQLILMIIEKGDFDDVSKTSFVSRALQAIMPRLENDIEIVDETAELARLAKALLFSLDLGADCFKQNELAELVSDRVFQLFQISLRAIITIGTKISLKELYYNICFQYLSSMTDLSKASGLYHRYNIKMLKSAGDKLIDTVCDDANNGESMCRISALFLLICFVKIEKVEDSKYVVNSLIRLNFIGLLVESLRTISQDLNDVLIEDTDIYLSYCHAKFALLQEISQNRIGATAVCNADIFNAVEDSGLFAVDPDLGVNIKGPEAVEKYYSILAAVLRILCAIVLSRGPQNQQTLNSARKFLSVIRPSILNILKKSAGIGAKKNTTTNTIDDITDLILFLISYTGFLEIGYENTRKVPSRAFTSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P702</accession>
    <name>A0A0B1P702_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P702"/>
    <dbReference type="STRING" id="52586.A0A0B1P702"/>
    <dbReference type="HOGENOM" id="CLU_007884_7_0_1"/>
    <dbReference type="OMA" id="NMLVAND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="267"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="385" mass="43947" checksum="9A6133578E0E0A81" modified="2015-03-04" version="1">MMRTRFWKLSSFHRARFHHHQNIFYSSSCSSFPTATSSTCNFLSNRSLLAISGPDSTRYLQGAITRNINSNSSNGFYSVFLNAQGRILHDVFIYPFQEFEGRYKGEPGWLVEVDTKEVESLVKRIKRYRLDSKFEIRAVSQTERSVWVVSSDNIKEDQIEQLFVPNENKNYSEYVIGCVDRRAPGMGYRLLLPGNKKPEPDLVQCNEDYYRVRRYLKGVPEGQTELVKEQALPQESNIDVMGGIDYRKGCYIGQELTIRTHHTGVVRKRILPLQIYGVDEKEPNLLTFSDNINFGAENIPPNTTITRWNGTGRSVGKWLAGIGNIGLGLCRLSNMTEIEVEGEGKSYKMGDEFKVEWESNVGMKTVKVKAFAPLFAKPFLKSDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P749</accession>
    <name>A0A0B1P749_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative formyl-coenzyme a transferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001063">
        <property type="protein sequence ID" value="KHJ34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P749"/>
    <dbReference type="STRING" id="52586.A0A0B1P749"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_1"/>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="484" mass="53446" checksum="A7DF500EF38445F4" modified="2015-03-04" version="1">MKGQSTCAFWTRPDLPWERFDSGLLYLLLLINAMFKYTVLNRNVFQSLSCLFPNRIATSLVRQQRLGNMASSKLIDPTLPLQGFRVLDLTRVLAGPYCTQLLGDLGAEVIKVEHPTRGDDTRQWGPPFAAYQEGSGRLGPGESAYFLAVNRNKKSLALSFKQEAGVKILQKLASESDILVENYLPNTLKKYGLDYTTLQKINPRLIYASITGYGQTGPYRSRAGYDVMVEAGFGLMHITGPKNGPPVKVGVAVTDLTTGLYASNSIMAAIIVRAKTGMGQYIDLALSDCQVATLSNIASSCLISGENDDGRWGTAHPSIVPYRSFKTKDGEILLGGGNNHLFGLICDGIKQPELKTDCRFIDNVSRVTNRYELESIIESVTLTETTRYWLNLFEGSGLPCSEIRDIKNTLSNEHVLARGMIEEIEHNFCGPIKLLNIPMKFSQSRPRIRSAPPILGEHTVSVLKDVLGFKDEEIAELKKVGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B3</accession>
    <name>A0A0B1P7B3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001983">
        <property type="protein sequence ID" value="KHJ32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B3"/>
    <dbReference type="HOGENOM" id="CLU_151460_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="8225" checksum="6768BB253A8FE8D5" modified="2015-03-04" version="1">MTLPAKSKSSPSRGAGVNAQYALHVWDSQEVSHYPSLRDSHSSPRVSIVFVSTSPSPQHLFHEAPHDWPREYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C8</accession>
    <name>A0A0B1P7C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative quinate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000789">
        <property type="protein sequence ID" value="KHJ34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7C8"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="CCMIVAT"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF81">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="61582" checksum="8538E98AC01777F5" modified="2015-03-04" version="1">MAKLTSWFIEFIGDIKKHQNAYLVTILASFGGMLFGWDTGLIGGVLTMESFQRSFALRNTTPEEQKNFSFISGNIVSVLQAGCFFGAMSSYYLSHHHGRKSALMQGTLIFLLGSTLQACSGINTTSLTLLYIGRIVGGLGVGIISAVVPTYIGENTSKDIRGRCIGTMQLFNCSGIMISFFVNYGIISSAVAGTSLEWRIPFALQMIPGIFLLVGLVTQYETPRWLIMKRRETEAKVVLRHLSGKIIDEARLLQEFNEINIDLHGREDLSLSQQVISACENRKILYRVTLGAILMFWQQWTGTNSINYYAPQIFSSIGLKDQKTQLLATGMYGVVKAIMAMMALLIAIEQIGRKYSLMISSAGQAFCMLYIGIQNKMASNTPISSLSASGIFAVICVYLFVLFFSLGWGLVPYVLSAEVSPNHLRSLSMALSLMMQWINNFIIARLVPIMLNRIGFGTFIFFGNCSVLCFLFAMICVPETAGVPLERVHLLFEANILKGAFLDTFIRFRRSNKFKDSFNGVDDMNDAANLCNEQILVTKSGSDTERNLIISRNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Q0</accession>
    <name>A0A0B1P7Q0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative pre-mrna-splicing factor cwc23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Q0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Q0"/>
    <dbReference type="HOGENOM" id="CLU_073392_0_0_1"/>
    <dbReference type="OMA" id="KWELFER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="33304" checksum="0F95E6C693224C77" modified="2015-03-04" version="1">MANSECKKWLTSDLDFYEILGIEFEACSESELRRAYRKTALKYHPDKVGINFDPEKYEIFQAAYHILSDSSLKSQYDQFRHAKIQKQRANDMFEGKRRRMKEELEAREKNGVPNVNKRSRENEARQMELQPELKRLAEEGRKRRAVREKKMAENAMSSPSPVPLKEGCYSKDAETKVKNMEDDEKIKRLEQKIREAEEAKAKYKLKRKIEKGSPKILVDNESLYNGTRFEEQGNQTSQPIPSISKGIPLDEKSSSAKFSSLPTSYKDDFATTMARLRAAEKARQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7T0</accession>
    <name>A0A0B1P7T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000967">
        <property type="protein sequence ID" value="KHJ34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7T0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7T0"/>
    <dbReference type="HOGENOM" id="CLU_020266_0_0_1"/>
    <dbReference type="OMA" id="LLWRHHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="613" mass="72172" checksum="912C79FC52E5827B" modified="2015-03-04" version="1">MNLPTFELHCSNETHLLRLPDEVIQKILFFCDPDDVYLNVKRVCQRFFRLVNEPLLWRFHCCVNFRYWDKRHGFQEKLRRPTGQEDWKSLYCYRRMVDLKTTELLNSILETQTNRISKYEAIARFGYDAKETLLRHIQVDENAHDVLARRYYAKSVLDYIHRIIALEEWQKILDNKNVPIESALGCFDLFILQDRTGDFSEISVMFDKIAQRFRCEYLGIDNLSPKAKAQALIDFMRRHCFIGNLSSWAYERIQSYFIGLYLQDPECPPLPLISITIFCAIGRRINLDAHCCGIPDYLHVVVLPRPGETLDAKKLKDGETCGEPMYLDPYQFMREVPIQILRKNLSNLGFQSSLHMRYLSDMSTASLVQRMSKTIMTTVNNLRANQENFRADGHSVARQSNFSTAELEKAHYSALWADFLFADRSRLLTSGVQQSHLVPIILERNERLYPMDACLIEKYILPFYNNHRNSRSSETYNQILETLRDLRNADQTPKMIRLRRPPANQNVRYKIGQVFRHKRYYYTGVIIGWDLEGENFDWAFTNDARSLLFGMYQSFYNVLVEDTSIRYVAEENIEILKPEFPSSLMSLAGKYFNRWDGESHIFISAIRDEYPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y9</accession>
    <name>A0A0B1P7Y9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y9"/>
    <dbReference type="HOGENOM" id="CLU_094649_1_0_1"/>
    <dbReference type="OMA" id="SFWWLRS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="22068" checksum="19A8435AEDCA0FA8" modified="2015-03-04" version="1">MSLSPDTLEGKIIRQKRDELSSKILVPTFQVGVLSGLSGLFIGAIAGTLRCANPILFSLASGIQCSILGSSITAFRKAIIHSRGNDELSPNEKLSISSISGALGGGTTGAILRGRKNVIPGAVMFAILMTTGQFLFNKLEQRDLRHIPRDSDNFYSWMRSKWLPLRFMSDEEYETILKKQLCVIKAEIALIDKKIQAIQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P881</accession>
    <name>A0A0B1P881_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative wd repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001358">
        <property type="protein sequence ID" value="KHJ33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P881"/>
    <dbReference type="STRING" id="52586.A0A0B1P881"/>
    <dbReference type="HOGENOM" id="CLU_004759_5_0_1"/>
    <dbReference type="OMA" id="CPINSEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="912" mass="101424" checksum="7E9165EFBF290F37" modified="2015-03-04" version="1">MSDCVKTPKVEVTSGLHNVTVTEKLVLLPEMGHQAQSNCPINSEVCSLQTSEIIPSFSESNLPQKNQNEKSSPYLDQNTTGTEISISRIPITCDLKKEDATNKQALQMENYTSKMSPQAEMSLLRSNAGVSKHETLPQKEKTKGVSFLSRLANKGGKKKELTDDPNIVRNDTLIDGISVNGLKSSVNASGFAPQKKEPRSYIRVRSRKKKEKVFDHLFLAQELSRGNSSKKENTSDSPLTESGPENDKSHLAVSKSGNAIWAMEFSLDGRYLATAGCDHIVRVWVVLSNPDDRRTFEHEEKLSLRVTDYDYLSAPVFKSKPLREYLGHNGDVLEVNWSKNNFLLTSSLDKMIKLWHPSRQECLTTFCQKELITSITFHPTDDRFFLSGSLDCILRLWSIPEKDIVFSCETPDPITAVAFTPNGSIAIAGSSSGLCNLYDIDQENGLKFRNQIHVRSSRGKNSKGSKITGIKTLFLPPDDQDTGDVSILVSSNDSRIRLYKLKDSQLEMKFQGHQNTHSQIKASFSCDGRYIICGSENRKTYMWGAKSKDSDPKEPTLMEMFTAHNSIVTTAIFAPAATRRLLSESEDPIYDICNPPPVTLLSLEERFAESLESNGNPSSASMSKKAKVSPTYLSRTSHDDGPIILTSDMNGSIKCFRIDCAFEKRHHFDAGSVFSKKGSSIRRSDSFMTRTSTSSRQDSLEQSSSLRSIYRQNVLNWRGKVSNEPMQNSQREESITPEIVIAKTDQHSLSFTPQINVEDTLDKLTQTASLKGKSISASKSVCNLARSANFPPTPGFSLTNSNKSDELTQRFSQIGKSGSFWNRSNWQSSLSSRTSRDTDSKGLEAEYLTARNIHNEEDLIKIPTVEASQSDTSGFESDQHCCEMCDGKDFRARKVSGKGLVMVCIRCGVIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A6</accession>
    <name>A0A0B1P8A6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8A6"/>
    <dbReference type="HOGENOM" id="CLU_046570_0_0_1"/>
    <dbReference type="OMA" id="INKRWHW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="38"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="374" mass="40971" checksum="2B56576F7567D101" modified="2015-03-04" version="1">MPPSATPQILLSPAELSYLHSSLSLSPPIRSDGRTATQFRPLVAETGILSGTNGSARICFADGSEAIVGVKAEIEKCLPMEPNGTVQDIDIEKLSLINTTNTRRKKNAKWNLWVEVDVELPGYRDDDAMPVLLASILTEALLADGQQPAGLHINRRFHWKLYLDVRSRNSGQILLLSQPLSYPLPLLSLASHLALLSTRLPRLKSEEDDDPLFDDDWDAATYLYPRNDRDFIRPPVTLLVMAVKDNIIFDPSREELAVAEVVLAISIGIADNEQEKSQVDSTRSLKLLSVRTIDPPSRLAFPGVPNALNAATRGSSTVLEDAASHSKFYEEEGVWQPPRGGAKRKLIAAMIRQALATGGVADEVLDGLELVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H2</accession>
    <name>A0A0B1P8H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sec20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8H2"/>
    <dbReference type="HOGENOM" id="CLU_038503_1_0_1"/>
    <dbReference type="OMA" id="NTIMHES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="10">
        <location>
            <begin position="191"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="307" mass="35322" checksum="B06FBD7B465C861C" modified="2015-03-04" version="1">MNTELFFEKSAALQESNTQVQELINRLANIEFQPGSVPLLDYGGDYENNDGVLSELVAEILQMIKEQEEDLELLKEEIHDLNPGRSDVLLIRQQEELNVQVQLTIAELKTHHKSFQRAQLSAKRRLEMARTQERVALTQSYLEYAQIYSDSTNLSSSPLTFTELENHPLKKNRQQRPLLSLSNEEKEINAASEVITVLRRTHNLMANELSRSQFANDTLKGSTEALAQLAQTYSTLDTLLLTSRNLVGTLLRTQKSDTWYLETAFYILLSTICWLVFRRLLYGPLLWFLWYPIKIVVKTTSRVLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B9</accession>
    <name>A0A0B1P9B9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001358">
        <property type="protein sequence ID" value="KHJ33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9B9"/>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="29253" checksum="309E6AF86C0088ED" modified="2015-03-04" version="1">MPPKSGKKAAPAPFPQSKAGSKKTTKNPLLERRSRNFGIGQNIQPRRNLSRMVKWPEYIRLQRQKKILNLRLKVPPAIAQFQNVLDRNTAAKAFSLLNKYRPESKGEKKERLLKEATAIKNGNKEDVSKKPYTVKYGLNHVVGLVENKKASLVLIPNDVDPIELVIFLPALCRKMGVPYAIIKGKARLGTVVHKKTAAVLAITEVRSEDKSELSKLIQAIKEGYSEKYEEAKRHWGGGIMGAKANVRMEKKQKALEAAIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9H2</accession>
    <name>A0A0B1P9H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001534">
        <property type="protein sequence ID" value="KHJ33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9H2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9H2"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OMA" id="CFVNLPG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="546" mass="58923" checksum="2AAC9FEF0E8E0865" modified="2015-03-04" version="1">MTFEASTTKDDIESTLHETGPPKANSPLFPSDSSGVVDLMFQTKNEEECDRHKAGGNGLLGKLQRLEGWLDNKMGIETQGVDRIPEADKVPPSVFNMFLMWWSLTCHVGALPMGMLGPDFGLTFRQCLAAIIIGAFLGSACSASCGTLGPKLGLRAIATARYSFGFYGAKVCSLINIVTGAGYATVNAVVVGQLLSSVTEQKLSPSIGCILIGVLSYVISIFGFKVIHSYVKYAWIGSFIVLCILLGQICSKVDISRKATQTGLPHVGAFLSFLTINFSSSATWGTVAADYFCNYPANTPKWKIYFLMIFGIVLPTSFTAIVGACLGNIAFNVTSETGSNLTSYAYPVFAEAYHDHGLGGILRVSYYPDVLSRIILTLLSFSVLANNIVVNYSVGLSFQLLGDCFHAVPRFIWSLLIAILITVLAVIGRENLSNIVANFVSMLGYWAISFTLILGIEDGVFRRRSGYNLDYWNVPSKLPWGIAAMAALLVSYLAGGLTGMSQSLYVGPIARKFGGNGGDVGVILSGLFTLIIYPIVRFYELKAYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9R8</accession>
    <name>A0A0B1P9R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nicotianamine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001063">
        <property type="protein sequence ID" value="KHJ34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9R8"/>
    <dbReference type="HOGENOM" id="CLU_031919_1_0_1"/>
    <dbReference type="OMA" id="DTIFHNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="34659" checksum="FD51170AE824FE5D" modified="2015-03-04" version="1">MFTFLPQLFRGLAGLKRISIPDNQEKSEANVLIKKILHIHAELASKEDLEPCAEVNELYSDLVDICTLPVTEEFSNMILENDKILKILHDLRNFCSIIEFNTEKHWSIKAAGTEDVTEQAVCKCIENIPHIDINMELISDELSAMRVVSQKLIESIAIVGSGPLPLTGLGLTGMLFGTSTDIRILNIDRELNAIEAAKKLCNRLGSKAKGMEFLCAEAGSAIHLSEFDVVYLAILVGNTQQEKELLLKNLVSEMRPGALLIVRGTTKLKRLMYSVFDPNTKPVAQILDVETVIYPKNHYIVDTVTIGRVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA13</accession>
    <name>A0A0B1PA13_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative nucleolar gtp-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000532">
        <property type="protein sequence ID" value="KHJ35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA13"/>
    <dbReference type="STRING" id="52586.A0A0B1PA13"/>
    <dbReference type="HOGENOM" id="CLU_011106_5_5_1"/>
    <dbReference type="OMA" id="FKLDGLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="189"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="541" mass="60389" checksum="BF95EDC4ED2DEBED" modified="2015-03-04" version="1">MGGVNKPGKPKSKRQPVRLRHKIEKASAAKQRKARKEKKKCSEWQSKLKKDPGIPNLFPYKNRILAEIEEARRKKLEEVERRKAELKLAKNGSKKGSEVDFELMSDVEHVGNEVKEDNITDDKMVEEDIDEEENPMAALLASARAAAKDYEQDIDSEDEMDEDDVSSDGYDEDEDDVSSNLHLQTEGSRKAFDKVFKQVVEQADVILYVLDARDPEGTRSKEVERMVMAAASGGKRLILILNKIDLIPPGVLRDWLIYLRRYFPTIPLRASTPAPNSRTFDHNQLTIKATSATLFKALKSFASSKNLKRFITVGVIGYPNVGKSSVINTLTTRLGGSGVACPVGAEAGVTTSLRLVKLDSKLKLLDSPGIVFPCSENEGKSSSKQEDQARLILLNAIPPKMIEDPVPAVTLLLKRLKSNNMFAKLLDVYNLPPLISNNGDYTMDFLVQVARKRGRLGKGGIPNIHSAGMMVLTDWRDGRIQGWTDPPNLKNLTGNKNSNSNNNITMDQKEIVSEWAAEFKLEGLWSNGDKDVEEEREIQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA40</accession>
    <name>A0A0B1PA40_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="JNVN01000516">
        <property type="protein sequence ID" value="KHJ35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA40"/>
    <dbReference type="STRING" id="52586.A0A0B1PA40"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OMA" id="LWRETVQ"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="369" mass="39760" checksum="035A277073F0F4A8" modified="2015-03-04" version="1">MSVHNIVIFAGDYCGPEVTAEALKIFKVIEALRPSAGKFQFHEHLLGGCSIDATGEPLTLQALEAAKAADAVLLGAIGGPKWATSTVRPEQGILTLRKEMGTYGNLRPCNFASESLVESSPLKESVCRGTDFNIIRELTGGLYFGQRKEDDGDGFAWDTEQYSRYEIERITRLAAHLALQSVPPLPVWSLDKANVLASSRLWRKVVTEVMEKEFPQLKIGHHLIDSAAMLMIKNPRALNGIIVTSNLFGDIISDEASVIPGSIGLLPSASLAGVPDGKTRCNGIYEPIHGSAPDISGQGIVNPIGTILSVSMMFKYSLCLPLEAKAIEEAVKHTIDDGIRTKDIGGSNTTIEVGDAVCGHLRKLLLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAM5</accession>
    <name>A0A0B1PAM5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001094">
        <property type="protein sequence ID" value="KHJ34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAM5"/>
    <dbReference type="STRING" id="52586.A0A0B1PAM5"/>
    <dbReference type="HOGENOM" id="CLU_110781_4_0_1"/>
    <dbReference type="OMA" id="YPGFLFY"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="120" mass="13713" checksum="ABDFF1137036C1F2" modified="2015-03-04" version="1">MPSERENQINPIVQDSVRHNTKTLTALHNITASLFGVGAGTLGLESYFGFIFYILFSLFTSTLIYIFRVRPSNVTKKYQLKEIGTTTYFRSSRELWIDGLIDGLSSYILTWTLFYGLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS7</accession>
    <name>A0A0B1PAS7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g5090</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001066">
        <property type="protein sequence ID" value="KHJ34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAS7"/>
    <dbReference type="HOGENOM" id="CLU_004183_0_0_1"/>
    <dbReference type="OMA" id="EFQFRPM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="285"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121587" checksum="CEF14628D60A3C29" modified="2015-03-04" version="1">MIWYLLYPVRGTTKAPVLDQDHPLRYAFTRYGFNAARHPLITLFISFIVAVALIFPFPFFYTNDFTNGTSNLPHHVWTSAEPFQGPTTTSIDVVMRSFWVHGSYMKALQTNVLYNALEIQNYLLGPTMNFAPQQSAKAFSENSMAELTMEMRDRLHAINGLSNQSWFFHSPLQYWSCSVKIIEADEDILATINHNSRKATSVNTTLRHSIVFSGKRFEEHRLVAADALVITLVHMLESPVGRQWEIKAEELAMAKSDKWRLYPADGKSLASTLYEFRFQPLSFKDDLILGVVYIFTLTYLILSLSKLRAFKSRIGLIIAVIIQVGTSIVASFTVCAVFKIDLSKIPREAYPLVVLAVGMENISRFISAVVVTRSEVSTATRLGEALGKISHIALAGVGQNLAILWLLSRGTYPQITAFCTFAAIALIFDFFFLLTFFSAILSVDLQRMELNEALSKASSHNILMQMPIERLSRLTSIYTILKRILPLFSRIAGTIFLIGFALMAHWHFFDNESIYQVISHIAGQTLSHSSSTSLLSMDIHPARTPTAWIRMQDHETAHEVIQIIKPHANSIIARVYDPLIFVLDGSDRTPNESGVRPFLPAAYDFVKNQFGYFLFTFSMAIAALFLFLNYLLWDEFTDSEKRNQSNKEPLLSITTLSEGHALDIVLLVTSIDGILVTVGLDRRIWIWNLHNLELSYVIYDREKPLNVFPILALAIDNDSKWLAILSAQDRLFLWSIPERKWGPSMQVILHSRTPIGFFFGATLQFLLVSKNGSINTISRIRNEWVSKSIDLPHLKNDTGVFSIQPLPVLTSILVIREYTVDLVDISTQGIIYTFSTRKIQRNTLKCFYSVRRRQCGSVGLRSLAIAYNCAETGNCIMQIYLPRSGNDCIYLKEINSSCCLLREAAVARYEIKNPGQWETLQSGFLIGIRKRDSSSSITRSLSILKSDSNFRRRNVSSPSSHLSCSQKPYLDQESWEVWSISSQGEQYTQPLSDLFKKRDFLLVDRLGPLKVISRHGIAVGLGNTIKIISVGKENFKGVHDSNDDSFFQELGASRMMRRKKLLFTKKKPPLIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT9</accession>
    <name>A0A0B1PAT9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative c2h2 transcription factor swi5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000855">
        <property type="protein sequence ID" value="KHJ34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAT9"/>
    <dbReference type="SMR" id="A0A0B1PAT9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAT9"/>
    <dbReference type="HOGENOM" id="CLU_013390_1_0_1"/>
    <dbReference type="OMA" id="MLMMSKF"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF11">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="770" mass="87501" checksum="56E35AEEC51EFA98" modified="2015-03-04" version="1">MLSNQNSNLQVRQRQHRRQNSTPLAFEPVKVSSLPKIHKNHGHRRGMSLDQRRRQTPPQDRMTNHVSLGYLSAPQHILRETQQQRLVCPGQQYIQFNNNDDSCLSSPVVTPHRLSLDSNYINNYGENIPHSQLFPYHAPVNWAMEVDHTNLHKSSDFKLISSDPVAPTPTYLEFTSSLGERMEKPIPGDFERNSIGRRISDGIIDRVSQFENLALQVPHRPLTPSSYNTSNCFPPTPIDTPHVSMIKQEPTNIRFMDNYDTSMEETIKPSYKQRASGIFDDMRNEIELNSRLCLPDSSPMKEQISFDSTSLPMDNFMNLSNLHVELPDNVNKICSEPLFSPDSTDISSVLSGYQSSHEENQCIIITDPFSNDSNLNNTPQQYPEMLNKTSLSFSSPRRKSTHRRFDSTSTINLEDSILETGITTDEIASYISGPEPGDGAKWLCLYPNCRKRFGRKENIKSHVQTHLGDRQFQCPCCKKCFVRQHDLKRHAKIHSGIKPYPCQCGNSFARHDALTRHRQRGMCIGAFEGTVKKAAKRGRPRKNRPNDEQRLNKSSQTQRKNKEISASSSISGCSESGDFTPRSYCHENSNIKPCVEFDYQRAPLMTNISSYQDMQSQLLSNDPLFSSNTEAHCSTSFASSQNSNARSTSEITPVPDASRPKNEAHTNLYKSSPQIYESPSSPESLSNYFDMEPSQNGSEIHVNISSNSNLCAREEDLFLDLFPMTSQDSGMRNPRQDHNFLMGKFVDSLEQARRNEELISNPPEVFYDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAZ7</accession>
    <name>A0A0B1PAZ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative nuclear pore complex subunit nup133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000230">
        <property type="protein sequence ID" value="KHJ35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAZ7"/>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="109"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="658"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1346" mass="152727" checksum="93BBD4A22ADACD9B" modified="2015-03-04" version="1">MFSPPTIQNFTAQEHSQRTSRRRQRPLSSENSGSEPKSKRRRSAFALKLSLTPENTSEKHDTDNKNVKVAASQIIKDGPQGRDLAVRSKRIRSGEIDRKGDGSVILSANDLYSVAKLPALPDRLRSEPENRIRQHGAIYSSCGYAFILNYAHAIVWPYSVNSMSPETFVFTFNEPLKKASDPLPIGALVSASASSSIPGLVVIIPTTGKVTYWESVSSAATYDLRLQRNGVEFSIPLLFGETVDQALNAESTGFILTFSSGRIAYMGVRDGQGRPVISVQFLKIGSNSLTNGIIGSIRNVLSSSSIKGNIAAVRAGNSVKIGEREIVMATIKGKFHYWKMHRGGHTSLASEHEAREPILRAIKKTSQEISDTSIESFQIIDFTFIPKLGTTSESAQVIEEDTNLLVLFSIKEKNYSKYYLVHIHLRRDEPEVQNLFLIKSYTTSINHDALSKPRLHLPKPGLVGFVIFDRAVVVISVARLQLQNENEQFIQAFDDVIDFQHDIDVEIVGSGIEESYESSGIDDPKSLYFKPKHPAIVLLVRGSGVVRVSAINTDRLMSQNPQQVNAKTKLEQAVFYGSLDHNPLNFTVRPELKFCNDEFGAAAIELSDEILRSKTTYISTVAASIDQNLQKRSAALHNLAQYIYKNDINLNRITKWNLLFNAEKMKAASLVWKRFDAVMRTRCPGEKRGLLTEVVESIHENFKSAPVSETGEYDRVRHWFIHDIWNMEIAIPWAYQVIKCYWHDGHTDHNFVLQILSEANDLVINALQGAFEFRAKNLDLYGLLSEQIEDGVLVTGYEGLPEFWTSTTFITENTRKHSELAAVLLDAFWGKPSDKIQSPTLLSKIRNEYCNLVDITIRSNTERIRWCSAQETPEFLMEAKEIKCIQSKTQEQHISVLAGTLGLPDEAMNLAEKHQLMVVLASLLKLDLDTCTHLMKHKRVSEEMNDLILRKKQLQLRTENLFLKFGSKWATALFEVYLLDGSAGELLNSMSSQQNYLTRFLRSRPEYRKISWINDVIRERDFDQAAEALLQIGLKREDDLWSKKISLSIGKLSLCASKRQSNFDNSNPQLVPIGNKLSLIKIQEEIYSYISPIISDAIDQKAELDLVLESLENNALEDQPTFQQFLKERLSSLIKHKAMNVMELVDLLTLMDTGSYVEDTTFFSCQQFYLALKALSLEPPRGDENLVQQIIWRRCMLRDDWAEISDTNMKDDEIVSTQVRATILYQTLKLCYKFGLFEKEAILKPVTPQECLEAGTQTLDHRLQMLDVSIREKLMKEMQIESDALKLLIDSSQLNQWHKTLLDLVKLDLEKELEEEVENEKRVQHAAEQLRSIEELLKNSRQCYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB23</accession>
    <name>A0A0B1PB23_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB23"/>
    <dbReference type="STRING" id="52586.A0A0B1PB23"/>
    <dbReference type="HOGENOM" id="CLU_076901_0_4_1"/>
    <dbReference type="OMA" id="VFGADMK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="154" mass="16728" checksum="5AAFC0F74664D211" modified="2015-03-04" version="1">MKAILQRVLSASVSVDKNLVSSIGKGVLVFAAIAPGDTEKEIDTIAAKVVNMKLWSDETGNRWKLNVGDIEGEILCVSQFTLLASTRKGSKPDFHGAMGGEKAKELYQLFVERVKEKYIMEKVKEGIFQANMEVALVNDGPVTLEISAGQAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB59</accession>
    <name>A0A0B1PB59_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative member of ferritin superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001173">
        <property type="protein sequence ID" value="KHJ33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB59"/>
    <dbReference type="STRING" id="52586.A0A0B1PB59"/>
    <dbReference type="HOGENOM" id="CLU_029630_0_1_1"/>
    <dbReference type="OMA" id="EVYMMIT"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079890" evidence="1">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="329" mass="34011" checksum="24C870FB6A343613" modified="2015-03-04" version="1">MHYTKNIVTILAMSLVGSVCALPGQPKLSYKARRAFEIGQGLRRTILESRQNPATGLPDGLGDLDVLEFALTLENLETSFYQQGFAKFPDSDFAALGLQPIEIANLKSIGGTEATHVTTLTAALAGAGAAPVQPCQYNFNLTTASAMVATAGVLENIGVSAYLAAAPLVKSPDVLTVAAEIVTVEARHQTFIRTASKAAAIPSAFDTPLGIRAVYTLAAPFIQSCPAGSNLAITPFPPLMMEPGTENMKIAAGSQVKLQSPAAAGAMSCAFVNGGQMGGTAFAQFQNGACVVPMGLGGITYVHLASTMPTNGMLTDAITLAGPMVMMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBC7</accession>
    <name>A0A0B1PBC7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000167">
        <property type="protein sequence ID" value="KHJ36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBC7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBC7"/>
    <dbReference type="HOGENOM" id="CLU_027663_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="58843" checksum="754EAF0CD1172BA0" modified="2015-03-04" version="1">MWSEKSAKVFLKSRQPPPEGQPGTPSTVVVPVNTLIPSTDNATSTSTSTSDPRTPPQNLDSQSSIVAITAASLALIVAFIFAFYFLRHCRQMRNTLDSSSNYNIFKSLWSKTKISNKKNRIQSTDEQQFSTAPREHVADTNDSRSLEMAENFERPDRTASFRSVITLPSYIPTARQDEQVLGREGERGGIDVVVEFPTTAEEEEQRREEEMEALYQVRLARRRENQSREERRRTRRATRDRGESSTPRENGDGRRHSMNVPGQTIEELRSAHERLKSSRQRAVSIVSYAEIGVARHDGSRLNPGTPEIEQIGLLGDAASISANPYARGRNGSIRSIGSMSSEIPYPLMPQLSNPSNSSTFAPQTQFNAPPYILNSEPENNFTSPSLFRLQIWESPRVDSNAQSSTVSIIESANVVQENTLPENIPPDYTTIPFENSMEPEELPPNYSISSREYNEQNVRANETDLSSSEINENNDNIANTAMGSDGNELDSSVSSPDGNVLSIRTQILPSIQINLASPTADRGIETPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBC8</accession>
    <name>A0A0B1PBC8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001132">
        <property type="protein sequence ID" value="KHJ33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBC8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBC8"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="OMA" id="NEWVERD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22791" checksum="A25BFA7ADEEF5C51" modified="2015-03-04" version="1">MLNKRIEWQMNNPTRGLKYVTLDKESTQLLVFTDSSFANNMDTSSQIGFVIVLVDKNKKANLIHWSSIKCKRITRSVLAAELFGMVHGFDIGVAIKSTLDMILSTTVPLILCTDSKSLYECLVKLGTTQEKRLMVDLMSLRQSYERRLITEIRWIKGSTNPADAMTKSSPCKALQHIIDTNTVEIEINEWVERDNYALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBE6</accession>
    <name>A0A0B1PBE6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2157</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001126">
        <property type="protein sequence ID" value="KHJ33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBE6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBE6"/>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="21562" checksum="AB3EA218034877BB" modified="2015-03-04" version="1">MAFRGRGRGTSANTTGANNRGSGGFSARGRAGFGRDNGPPSEIIEMGSFLHSCEGELVCESVNVKIPYFNAPIFLQNKTSIGKVDEILGPITSLYFTIKPSEGIQASSFKAGDKFYIGGDRLLPLEKFLPKPKPPPGAPKPKRAGAKGGRGAPMKGGRGGGRGSARGRGGFSSRGSSGRGASNFSRSGSGFTPRGRGTGRGGYSSQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC14</accession>
    <name>A0A0B1PC14_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC14"/>
    <dbReference type="HOGENOM" id="CLU_1355551_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="23272" checksum="4BD06D50A1184B26" modified="2015-03-04" version="1">MKVDYILLSVCVNDYCFVNTNEIDKVPVNAQSDDTLNSARNICQLTSTSLYATCFDCRKQEHARHFPTVFEPLPIQRPSDYLEDVDVNEEKVDQIAAKIGLFDIEEEEVFNGPFPEEAPIWDDPIFLFSQLQSREFRNHDEIQRRLQADEGTNDLNHEDNIVPNDPFAEENVQIQINEIAQSQNLLPIDPFLESYPPPQAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC22</accession>
    <name>A0A0B1PC22_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative avra10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000630">
        <property type="protein sequence ID" value="KHJ34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC22"/>
    <dbReference type="HOGENOM" id="CLU_1846601_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="157" mass="18378" checksum="14DAC892F357FC74" modified="2015-03-04" version="1">MALVGTEECMTIDHHPICGFIPSHKVTAVNPPKLDWKLKFLKANLPHLARVVSQWLPQIADLKTVEEIEIFAQDICWALANALEAVGRRPIKQSRRSALWRTRECKFAHLDYREAVNKSKRSTKVWKLRNAVVSENREHWKKRIEDMRSLRDIFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC85</accession>
    <name>A0A0B1PC85_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000597">
        <property type="protein sequence ID" value="KHJ34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC85"/>
    <dbReference type="HOGENOM" id="CLU_017407_0_0_1"/>
    <dbReference type="OMA" id="IIRQHHP"/>
    <dbReference type="OrthoDB" id="5402147at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="587" mass="66090" checksum="AB3A5A9FD6C79BF7" modified="2015-03-04" version="1">MAFHQPTLQVSKKWTSSVSEGFFPQLAQPQQHQRARQRQQPPDSQEWVLFDPIGTGSTELSYKNSDTRTFTLGCSQVSDVRSLESGVWSYNVDESLEGGDENEREEEELDSLDSHLLDFKSEPNASYDPEPEPVDTVLPTHDGLGSFRLGRTIMGQDIQQYLYKFEKFNPNRSSKPREESEVDQMKLDTHQLQDAEWLRRIQVWRLEQSRVLDEIQRESRQKKHGTIKARNNTAEELAQETIATLSGPVVEATSDEKESFLSRITRKVIQDLIGIDDNLLSIIFGESLACDSEKSKTSELHQDESSKVYDQISWEYKILQHIARELEKLANKISDSPLRLNTYLHPQNIAISYAGLPIIPENIDSQSPLSQDLKLESSFLSGPFDPEFHSTVKTRAQSTPHLSSITSNNSDDKEKTPHAREGLKRELTRDEWERDLDLKLVFRYIFDRVATRFSSSSSPSNSNQADSTKQRTVLGTVDTATRAACVRRHHPLISGRAAKKKSIRPINRTWTVSVPHSSVPGGTPSPRPLGVNFNTHKNSSLGSGSCAGEQGKKVMSESSRNYWDWAESVGSSKTTPGIGTMGSWGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC90</accession>
    <name>A0A0B1PC90_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000225">
        <property type="protein sequence ID" value="KHJ35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC90"/>
    <dbReference type="HOGENOM" id="CLU_2374331_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="95" mass="11154" checksum="CA9FDBD74CCC6167" modified="2015-03-04" version="1">MSMSSKKLTYCDRDEIQAKDENENVKDGKANGDLNKNQNVSSTTHRRHRIAHIFFPRKKERSDSTNSRLQENYEKEAPKVLFFSSSYIDEKKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH0</accession>
    <name>A0A0B1PCH0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative duf1212 domain membrane protein prm10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000044">
        <property type="protein sequence ID" value="KHJ36372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCH0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCH0"/>
    <dbReference type="HOGENOM" id="CLU_007078_4_3_1"/>
    <dbReference type="OMA" id="TIFMGVC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="7">
        <location>
            <begin position="141"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="8">
        <location>
            <begin position="408"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="574" mass="61782" checksum="FF88ED90415EB583" modified="2015-03-04" version="1">MDDGKNSSNIPNAWQNSGRVLSYISNLYSIAENNSLHGSNKATSVQSAQELGMTEAKMDNGRKNIDVSSVPESYFSSNEAFNYKGFDNGGRPNLIRQLSGATLTDVPKSKLSTKLEFSKYGFGEDFKVTIHISEAQIRQNYLLKLCQALMAFGAPTHRLEEHLITSARVLEVRASFLYIPGCMIVSFDDDSTQTNEVKLVKVVQGVSLGLLVDIHKIYKGVIHDKISVEEASQLLDKINNGGPIYNPWLTVIFCGLASAFVSPWAFQGRFIDMPVCFVLGCIVGILQIIVAPKSELYNNLFEIAATIITSFLARAVGSFQNGSLFCFSAMAQSALALMLPGYIVLNGCLEMQSKSMVAGGVRVVYGLIITFFLEFGISIGTALYGILDPNASNATTCDNDLSDPQKWIFVPLFALFAGLANQARLKQTPVMMAIAFAGFMANFLSRQKYPASAQISNTIGAFTVGLLGNILSRVQQGVAAAALLPSILVLVPSGIAASGSLISGLHSADIILNNDNTINGTSLVSLSPNEDLTKIVASVGNTMIQLAVGITVGLFLSTLLVYPFGKKRSSLFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL1</accession>
    <name>A0A0B1PCL1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000532">
        <property type="protein sequence ID" value="KHJ35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCL1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="54901" checksum="93E36D7A2A121FDC" modified="2015-03-04" version="1">MTQSASNETYQIPAYLPKELRDIIQKRQEQERAWHFRLSICASAICNIESTLENYKGDIEKREADLIRGYLQQAIARLAASNNVPKPPPIPLKTTPLRSTIHKEGQDLERKKLSSGTSKSPTIQSILKPQKVVFEDYNKSAIEKSSWVTVARNGHKKSRIIASTPSVPSAKILDIQKNMPQASNINQSHKKKVIVPISNSRLFVRLPINHEWRTLSLSGLREVIVKRLGVSPASIGLIKPVRTGFALSPCSSEAREALLQTSSRLLNTGAKIEPASNWIPLLVPTVPKYISTLEGQIEVNKEMLANEIERVTSIRPTSVRLYGSSNQAAPHRTWMAFFTKAPRSGLRVFDESGKVTFFKKQKAIDFCKRCNGHHPSRNCSRAPSCGNCGSVMHTENDCKALTKCKNCGGPHRSDSHKCLARPTRSGGPTKEQLKTFRTVGEREYQAVARAKAAEQKALASEDNILISSSQSPEHSNPTNQQSPVEFSIGEQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCN9</accession>
    <name>A0A0B1PCN9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000018">
        <property type="protein sequence ID" value="KHJ36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCN9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCN9"/>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25341" checksum="F2830562D8CD0FAB" modified="2015-03-04" version="1">MCDIPQTRVTVLISGEGSNLQALIDASQSRLKYIHIVRVISNRLGANGLNRAKAAGIPIKYHNLIAGKYYLKAENDQEKKKQGREKYDADLADIVLADKPDIVVCAGFLQILTPYFLDPMKKQNIPVINLHPALYGKYDGENAIRRAYNDFIDGKLENNRTGIMIHYVIKEVDRGEPVIEKEVECHKSESFERLEERMHEEEHKLIVEGVAIAISELWKKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP3</accession>
    <name>A0A0B1PCP3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP3"/>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="49463" checksum="9001A7B953D76111" modified="2015-03-04" version="1">MSSSSSKTLVLDNGAYTIKAGFSSPLIEELAIPSLIPNCIARDRLKKIYIGSDLATCKDFSEIIFRRPVEKGYLVNWEAEKEIWEHEFFDTDAKLHCDPKETNLILTEAPNSLPALQNNCDQVIFEEFGFQRYLRCLASQLNAYNDVQTTIFNSSTKITCQNYSPPDEILMVIDSGYSHTTITPLLFGRPLQASIRRLDVGGKLLTNYLTRWLSMRNYDMMSETYVVNAIKEATCYITNDFKTDMERAWSDSKRSHYFKKGLESSIVKDYVLPDYHFRSEGLVKVHDPDAATKLKELITGRQLGATEDIITLRNEQFMVPEILFNPIEIGLQQSGIAQQVMDSLSSLPLALWPGLLANIVCVGGNANLEGFIVRLQSEIRALAPTECIVRIARPPNPITSSWLGGASLAKQENILEMLSVTKEEYDENGAGWVARKFAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCR8</accession>
    <name>A0A0B1PCR8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gpi-anchored cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000739">
        <property type="protein sequence ID" value="KHJ34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCR8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCR8"/>
    <dbReference type="HOGENOM" id="CLU_664290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="414" mass="45855" checksum="B70375E33EA650D8" modified="2015-03-04" version="1">MSLNGLGDPNIKEAREKAVSEPGGWFLLKYASRDKVDLLARGDSGTVEMQETIARYEDSSPLFGFLRFRRKSVLIKYVPGGCSRLVQARVTVHFNAISDHFPHDLTFSITSSHELRDTALSAACSFHSTSGSTSSSTSSLQRRQLMEITEEEEEETRVNRKSVASDISEGEFCVAKVISISESSISPSSKDRTSLSGRQQWDAHTTRSSISLLSSDFQPDISTHRTSSDYTERLSESFIYPPFTSSSRSKIRLGPRPSHDDRRSFASRSSSYRPISALPAGLKSFAKWNNYEKEVIRPTSDSGNQTIVMNSPPSSPSSSMLMADIMIRQNSGNEQPNSSNERPTSSSELSFRSIPSPTLSVASTKNSTIDSARARLLKAQEMWKKKMEAADALHSSSIKVDTIIPDMRCDMVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCZ6</accession>
    <name>A0A0B1PCZ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000478">
        <property type="protein sequence ID" value="KHJ35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCZ6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCZ6"/>
    <dbReference type="HOGENOM" id="CLU_334059_0_0_1"/>
    <dbReference type="OMA" id="ETICNEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="855" mass="96963" checksum="61D67F811477B51E" modified="2015-03-04" version="1">MHEAGVDITSIVKSKYIQKRNSSRKEIIAATMTTKSKSRSALPFGLRTTFQSRRSKSENPNVTKAVTEDTGSLRHIFEEALNAPSFQSAIAASLAQLIKPSIKDALDTIQPVVEAVCAHEVLLRKANSSVENLIAKLDKDSSRKESKVIDGLANEGHDKIQVVCNEVDCKITSNAIKSAPIERGFSQHVDDATSLIEISKNIKKQDSKIDQLSLYFNPFKDFITDYKSDAERRNAAREKFQHQIDQVSHLSTKIYTNTGENMDGIKSEMEDLKTKLEQITKLDDKLDKVITLTHLIEENVFELKENKTESDLLNLSQTNKIMVIDQLIRTIEAKLNNILPTLDRFQAQHAQVDSTRDTENNLLNEIISKFNSQQGFFDKFEGLLATQASNIAEGNENNIAQSKILHALMEHYETYKIDLGISKEKNALQLELVNEIKSLKITQKDVLTKVKNLTSICIDESKIQNNRHSPLQEQITELSTTIPNILAQLDEIKSKFENQANQNISLTKDSEETKNSFKLISENIETQTHLFSEIRDNISAEILTTLHDLEQKNLVQNSLLADIKETDVSAEILTLLHDIVQKNEMQQNLLTEIKKEDIRPKILATLNDLEENSNKNNNILTEINERNKSTEILTTIHDLEQKNEKQRNQLTDILTAFHDLDQKTEAHHNLLTEIKETNSNTRILQNLNELDKKSDIHKNILTEIKKTDISADILTKLRDLSQKNEEQLSLLFKTIEEKFQHVDLGTEILTNLQDLNDKVVADQVILQEIKGADKNTDILTTLQDLSKQNEVQQLSLEEIKQADICAEILTTIHDLGAKCDAQQTLLTEMKEVDVSVEILTTCMTLARNVMLSKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD16</accession>
    <name>A0A0B1PD16_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000818">
        <property type="protein sequence ID" value="KHJ34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD16"/>
    <dbReference type="HOGENOM" id="CLU_1116451_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="249" mass="29332" checksum="FA05834035F2D4DB" modified="2015-03-04" version="1">MNKILSINDVYVNTKVVDELENINNRFDDTEAETSPTESHSDHQYHYSNDDYGIDNDRRDCHIWSGEYKSMFDTSHIERLRVLPEEIKDQFHLFDCNADYEITKHLSKSIIDLVPATSEINDKASKTNYYKSMEDDENRTLNLIDQYSPRLNDSSECQRNSFEVEYYPPTSMDYYFQEFNDGINQLTRWSVRMKELISLDPKEFKTALESFRDQTGENPLRIWTVKANAVIGLMRDIQYDMESGNYGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD50</accession>
    <name>A0A0B1PD50_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitochondrial folate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g3093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000450">
        <property type="protein sequence ID" value="KHJ35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD50"/>
    <dbReference type="STRING" id="52586.A0A0B1PD50"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="125"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="237"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="394" mass="43922" checksum="C9364AA442DC4769" modified="2015-03-04" version="1">MTERRVYRDAVQIETVAGFTAGTVSTLIFHPLDVIKTRLQIYRSTTSTPVTTYTIVRGLVSSGKPLQRLYRGLMPNLVGNSGSWSIFLGFKSVIEGQIIRYRIFMARDLAAPNDTCKASKQRDLLKPFDFFIASAVSGMMVSLTTNPIWVLKTRMVSSDRGKNGAYENMWQGVKLIYQKEGVKGFYRGAGISLLGNSHAAVQFSVYEPIKKFWRKYIRGDQNSGSRSEREDKLGTLATLAISGSAKIIAGTVTYPLQVVKSRLQVSELDHISGGRIMGVSGRLWREQGWRAFFKGLNINLVRVLPATWVTFLVYENTRYYLAVSLPVKSKSSPSRGASVNTQHALHVWDSQEDSHNPSLQEPHSSPRVSIFFVSTSLSPRHLLSRSPPRLAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDD0</accession>
    <name>A0A0B1PDD0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative n-glutamine methyltransferase mtq2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000604">
        <property type="protein sequence ID" value="KHJ34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDD0"/>
    <dbReference type="STRING" id="52586.A0A0B1PDD0"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_1_1"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="250" mass="27506" checksum="5510E89C6AFE9A7E" modified="2015-03-04" version="1">MIPTPSTSHVPYEKVYEPAEDSFLFLDTLSSDSEKAFLKNRFNQANDSSNINCKTPLVVEVGSGSGIVISFVHAHCETILGRTDVLTAGIDVNIHACKATEKTVSVAELQSVSHGFYLGNILGDLTMFLKPKQVDLLIFNPPYVPTPELPTIPMSDKGDVNMSDNSYLLSLSFSGGHDGMEITDRLLNYLPELLSPEYGCAYLLLCAQNKPEKVKNMIQNSGNGFLVKTVGVSGKYAGWEKLQIIRIWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDR4</accession>
    <name>A0A0B1PDR4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g4557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000704">
        <property type="protein sequence ID" value="KHJ34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDR4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDR4"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="57273" checksum="67451159C6A0F1BC" modified="2015-03-04" version="1">MATLQASNNSTNTSFKDREKPMAVRTANILAARAVADAVRTSLGPRGMDKMITNQKGQTIITNDGNTMLKSMAVMHPTAKMLVDLSSAQDVEAGDGTTSVVVIAGGLLGAAEKLLSKGIHPSVIAESFQRAASAAVRILHEMSHQVLLTDTSTLLQAATTSLSSKIVSQYSSLLAPIAVNAITKTIDIKTAENADLKSIRIIKKVGGTIEDTEMVEGLALNQLVLKNGGGPIRMEKAKIGLIQFQLSPPKPDMENQIVVNDYRQMDKILKEERTYLLNMVKKIKKAKCNVLFIQKSILRDAVNDLSLHFLAKLNILCVKDIERDEVEFICKSTGCKPIADIDSFTEDKLGSADLIEEVQKNGSKFVKVTGTKNAGKTVSIVCRGANSLILEEAERSLHDALCVVRCLVKKRALIAGGGAPEIEIASQLLKQARALKGTEAICWKAFAEALEVIPTTLAENAGLNSIKVVTELRFKHENGLKNAGISIKSGGVKDDIGDEKVLQPLLVSTSAIELAAETVKMILRIDDIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDR9</accession>
    <name>A0A0B1PDR9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000369">
        <property type="protein sequence ID" value="KHJ35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDR9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDR9"/>
    <dbReference type="HOGENOM" id="CLU_022564_2_0_1"/>
    <dbReference type="OMA" id="WTKSRIR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="528" mass="58780" checksum="F0244D2C0CAE3600" modified="2015-03-04" version="1">MSEKEKIKQGISTTPSIAEGKPEKNEPDTSDSDDYFSDAHSGLDHITSNNSLFSAQSNHSEEHETTVQNLLEDEIAPNQNNNSTASGQESPKIPRKFSLPIPITIVEKIDPSSLSHGEVPGTEAHEVRAADAAPDLVIKVTSGHSRPWSNRARASSTPGDRPIPITKVERIDRRPSYGEIPGTLAYEARRKDAIPDIIEEVEDIPVSPTLPRSHSLNQIYKLPSNIAPFNDSITRTSIENLEIEFDAENGDDFDDFEGGEEDAEFGEFDNSFQQATPSKSLPSSIQKINRFPVLDFTIYDTPEEIQDALEPYLNVLFPTDTIDNSVLPPLSDDNSTFLTPRSASLWTQLIAPPSLQPPRWIQSRIRRLFLVSLGVPVDLDEILPASKQKKLILPSVNLNPMSKSPRNSSDSPLNSRLKRGDDSESCISLDSQGKPSRQDSQRNIQLKPAPPTLDLFSARQLCMTTNEALSGLTGEEMKLHLKRLKRIESRAKEVLIFWTERKKEKLGDRDAFEGVIENLVKHARKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE32</accession>
    <name>A0A0B1PE32_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE32"/>
    <dbReference type="HOGENOM" id="CLU_1448744_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="187" mass="20940" checksum="A8D164C7BC887AAA" modified="2015-03-04" version="1">MVNRIIIFRAVSSKYKVYSGNIILQADAVVKTEILEDLSSSEINAGYPALSSSAPRKALIALPKVWHNTLGQPSLATIESLPNNVDGCDFDSTEKVSTVDFEPSLLPKAKAIFSRLPEKIGKFQFFNGEKHMVVVSWDIVELNTALDGLKYLFHFHYDNETSHHIKCTKIMVEAATYFKICFPKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE52</accession>
    <name>A0A0B1PE52_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative g-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000321">
        <property type="protein sequence ID" value="KHJ35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE52"/>
    <dbReference type="STRING" id="52586.A0A0B1PE52"/>
    <dbReference type="HOGENOM" id="CLU_026939_1_0_1"/>
    <dbReference type="OMA" id="LGPKFMW"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="471" mass="52420" checksum="4209D6EEB05A3C88" modified="2015-03-04" version="1">MSSNFSQVVPYGCPYPFLEADLFADKGGFLEGRFCSNLSGTNCCLPCPHAQWLYPKNFESMIERASWINFPGLLCSIFLIASFIILPAKKTHRHYLSVCLVTSVAVMNIAFLIPLGAKPSQCHDTITPNDMKSNITCAVSGALVIAGGWFGVIWVCLITLYIHLQICWQREVGDSFMCGAIFAGCTIPIIGVAVALGLSGVSFRIGNTCHVNADKSLISLWIPLLLIASLTLFMQLATFTYCLRVYLVSLGDYLTTSPSSDFRSLKRNRNILSPKKTYRRVHAVIQLQWRSILVVFVIVADVIFFAVVFVSLNQVESALANGNDKFTPWFNCLVEAGGDKEKCFVNINTPRISEGTVISVLVLLSLNGFWCLILLGRFSMLTGWRDLITGKSQTDLEFVCSDANTYKNSMDYEMLANMSDHGKPPELLTTPSRAILHDSYEEHDLPSPTYIWNTTLVQLDDPQHHQSKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEC8</accession>
    <name>A0A0B1PEC8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000587">
        <property type="protein sequence ID" value="KHJ34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEC8"/>
    <dbReference type="STRING" id="52586.A0A0B1PEC8"/>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="OMA" id="DHREKDG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="236" mass="27122" checksum="4FDD2868498C6BB8" modified="2015-03-04" version="1">MSSLSKNDESEFWLFGYGSFIWKPPPYFDKQIPGYVMGYLRRFWQVGVNLFTSMLKITYSFGLYMFPIYAYLPLISLHVSSEDHRGTPENPGRVVTLIERSFWNILDDIEPVPDEKVWGIAYHIEASKVAEVRECLDLREINGYSMKKILFNPKDTKETMQVFVYIGTPSNPQFTGPQQLESIAEIINKSTGISGSNREYLLCLEDALNRLSPPQSRDAHITKLANVIRGLDKNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PER2</accession>
    <name>A0A0B1PER2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protamine p1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000258">
        <property type="protein sequence ID" value="KHJ35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PER2"/>
    <dbReference type="STRING" id="52586.A0A0B1PER2"/>
    <dbReference type="HOGENOM" id="CLU_275445_0_0_1"/>
    <dbReference type="OMA" id="DETTICT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1175" mass="133237" checksum="FC77B5EFA0874B8A" modified="2015-03-04" version="1">MYTTKAHNVYDDEPFHFTPIFDPADIICEGSDTDQTPEQVKQKHLRYEAHAERCASGRLPVLQSTVLRRSLTSSWVNPWRCKPIKAFDEKRWQQSFPEKLVSNNGIDLRKTASSISDYLSPDDTISWCRTSGRDREDEADRSVADTEIFLVGTDRLDLIQLSQERCKGNFSHTRNKKLCEKVMEDHDLSFDNNDVIANRTKRGVKRQRRSLKSKRLRTTNFSNWDTESCSSHESFPNIVVKGKSKNRGFKNELPEQPSPLKFNHQKMLDSQKLFINSKSSSFSSSSSSLSIPKRPRKRYKVETHKGKYLEAGSDDYNSENSNSTSQNRKVSIYAAIRKNRINAPQINRTLPPTSLISPRSMDQDSFMTKISHSSRAIDKFTYKKKKRKRDWNCFNDVPDQSSQDSNYLLERKKKKIRVTKENQKDLLMKPVDIQRAWPKNSGNSGFSLVKTNPTFDCSVLTMRKPFKNSSKDNLSHVQDDFHSGSDLIEDIIAWGQEFNTESSPFISQEKKGHSQLNSDNDWELILQTTPRSNSRELESSSIFSTPGEKKCRSPFRQRLIQKTWTHQENSPKSSSQEFIVESSNKAGGSLLDSLTPLSPQESQIEKSFFSTSPSNIISKKIKSKDSSYNSTFTESNQAIEAPPLFIIPGPETSIQKKSSPETQFLTPKMPDSSGVTSPSRNRASRLSLNRDNSTSQILNVSPCINRLSNIDKCIKSPIPKIIDNNKFIENLNISFPHGGGKDFCDVQDDKQMPNLCQDKYIRYTGTSSEENQALQSPIIDRTETKMSDTYFDSTITNTEHSVIMNPILKNTKFLESDCTINDNSKPKFGTSNLKGDKPLNSNCQSPWAFETPNLSINFDRLKKLSDSALSFPSLKIANTFVSPHSSNIVEKIDFELPKINFNITPENKVSSLPSFNTTEKSHLSSQNDILKSYESAMKNPWKSSFKKSSAVRSKKRVSFQQSKWEVESLTEKHYASSPETPIRSFSQPDQMTDPSSLLLHERSNNLLAEKIPNLTNLKYSNNSEVNLSPGFSAMAEAFIAADKQTYGEKEGEEKDRISLSTHQLFVKSDVNDDNHDENDENDTGQSTMPMKTTINSPKGSNNVEDINDFAHSIGVIDDDHNDQQQQPNCWLDSPSIAPLRDIDFSVLAADNNNFDTLLCGVEDILEDWSVDKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PET5</accession>
    <name>A0A0B1PET5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g1637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PET5"/>
    <dbReference type="STRING" id="52586.A0A0B1PET5"/>
    <dbReference type="HOGENOM" id="CLU_138649_0_0_1"/>
    <dbReference type="OMA" id="EDWEDIW"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="14299" checksum="3B00552C5F8BA48E" modified="2015-03-04" version="1">MTKISTSFTALRTARSFRASNIICFPRIRCFSTTDELCGSDHAHESHYDPPGGWLFGVKPGEKRKKEDWEDIWVYGFFGSLAFGVVGYAFKPDTSIQTWALEEARRRLEIEGILEEPQDSHIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF82</accession>
    <name>A0A0B1PF82_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ndt80 like dna-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000177">
        <property type="protein sequence ID" value="KHJ35975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF82"/>
    <dbReference type="HOGENOM" id="CLU_026383_1_0_1"/>
    <dbReference type="OMA" id="VWTCYRR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="171"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="171"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="600" mass="65707" checksum="1D6A68D894F1B65F" modified="2015-03-04" version="1">MCSQSGSRHSLNPSNCIVDEPEPEGASRDNLSQVPSQLSVMGMRYLNVPSNDNRFNSDSITSQSSVYSLEPSIQNTPQSTNLGISPYNNYYPPPAQTLSTYSNGNGPGGSAYFAQNTLLSSMSDSIKPPRLSSLQASSGYMQSRGTPILSHISPPLSARELYSSHTPGIHRRSSDLITRSPTLPGNLRSMPISPTSTVGFTSPISNMNDTLGGNPVPPLYPTEVHYSLTTSEGHTVKPDIYGRIEKGFFMADNDWTCYRRNYFSLTCSYSLMPHVPIQTIFLHPNGASALQIHNFCISIAAVVDGRDGKPIELVQHTPKRDKGPQDKPARVVLSPRPPTTHGSYEGIGVRPSMYDAQGFNPNSNQPPTEITFERIQFKNATANNGKRRAAQQYYHLVVELFADVGNQNIDRYIKIATRMSAPMVVRGRSPGHYQSERRGSSNSNNGAGGASGASSGPYAPNGSQSRTSGDISMGGVSSMLPGSFNGNYDGRLHHYRSIPPLNVQQGQNISLEEVKHIDESTYYLYLPGTIYENNDSRYHLPVPDFNSSKLKSEFALFLPSLSLNQNSNGSGTRYCGRWNSMQDNKEYFPTTLNSQGMNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFI7</accession>
    <name>A0A0B1PFI7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000152">
        <property type="protein sequence ID" value="KHJ36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFI7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFI7"/>
    <dbReference type="ESTHER" id="uncne-a0a0b1pfi7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="OMA" id="LSWGRFI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="56"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="622" mass="69457" checksum="EB2BA9769E1BE9EF" modified="2015-03-04" version="1">MSFCWKKWIQTYKITMIYVILTAVVCIGSTQAFFLINNDSKKVFNPVVDVGYSVYRGYRSEVLQLDYFNGIRYAAPPIGQLRWQKPQEPKENRTEIISAANYGPKCPQSYQGPRPKSWFFMTNDEISEDCLFLNVISPINATGLPTLVWIHGGGYGLGDGRYNFTELITTNSRNFLVVTIQYRLGAFGFMSSPELSDFGTSNAGLYDQHFALEWIQKNIAKFGGDPRRVTIAGESAGAGSVMQQIVAYGGNEGTKFFKNAIVASPYYPPQWHFDDEQPTAAYNEFKKLVGCEERPKNMSVFECFSMKDSYSLQNASAYVSTGANYGQWAFLPVIDGVFIKKSPLDQLQAGEVNGLRMLSGHNSDEAPAFVPQIIQTKLDFNMYTQSLFPFLDQQTKTKISSIYDIPDTIPGPLFSTLGSVGLTALNQSSFAIGQQQRANNLFAEITFICPSYWLADAFSSLNKKSWKYQFSVPPAAHGTDMNAYYKSNAALFSKGTLSDGFRTGIQLSWGRFILHDDPTLPSFVVDAIGKNNEQINHEVLSAASNTSWLPWNKNSMTMMNFNSSGGTEKILTVMIALNKSINVTMHVNPGLIANWTISDASSWENGRGSRCNFWSSQKKYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFL0</accession>
    <name>A0A0B1PFL0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tfiie alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000430">
        <property type="protein sequence ID" value="KHJ35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFL0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFL0"/>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="49118" checksum="2EA4EC64D92B6C87" modified="2015-03-04" version="1">MELAKSLVRSCMRSFYDTKHILVVDALIIHSALRDDDLAYLMGMNLKELHKLCGRLNEDRFLAVHTRAEQKGEQTRLLSRTYYYIDYRATIDAIKWRVYLMNKHVQGSTIAQDERKEWFCKRCKSEWTQIDVLDRWDPELGFLCHKCSFPLTHDPDNNRGGHEQSTRYHAQFRFITDVLPKIDEVVIPENKFDQAMALRIEVIRDDTNPANETVPVNTTLTKPTTVKGMTNVAPAYISVTLTTSDGPTDVDLAAEKAMKEKVASQNVMPVHFTHSTVTGEQIKFGNQANDSLLLQETNKKSIADESTAIDGAEMDEYFSRLKAEQAREVEREKAEEEETDDEEEEDFEDVPVDNKTEISSDKIGKYSGPDYDNSNPLKRNSSTTKESNISPLEGLKVHTEERASKKIKTERSMAQEDNESEEDVEFEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFP3</accession>
    <name>A0A0B1PFP3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6331</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000418">
        <property type="protein sequence ID" value="KHJ35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFP3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFP3"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_2_1"/>
    <dbReference type="OMA" id="FRMAISE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="383"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="794" mass="88240" checksum="323F5BBC560B7101" modified="2015-03-04" version="1">MSRHKFIKGLDLNDELDDYDGGEDYDYSSEGESKGLNEEDQEKMTVSTIAVRASLPSSMEYLTDDVIHDSLWYTYYDVDKTVAYLVRAYASKTTKSTKSFAVKQVKGVKFTDSSCNYFSARYGNTCQHIRDISERHSKPFSYQDFFKDTPWLSVPINRQTTFIAPLSLRGGLLGGSGSSEPPKMSKLQTLAANRKKMAQQQKFGNLKNTENSLNKLHMSLSKQDGASGSSDITPKQLTPRSFPIRKRRMSNPTESNYITFKKEDSKSEEILMNENTLLNIAKPSEFAITMFRSFPPDNYRQHLMIPCPVNTLTDPFAEPSPDDIALAAQSKAKGKSKAQLQIKKETKSGGLIKNLKSLKVDDPPKIRSKNLNVLEEFKKQESKQIVSFVVIGHVDAGKSTLMGRLLLEVGTIDQRTVDKYKKGAEAIGKTSFALAWVLDQGSEERERGVTIDIALNEFETKKTKFTIIDAPGHQDFIPNMIAGASQADFAVLVIDASTGSFESGLKGQTKEHALLVRSIGIQRLIIAVNKLDNVQWSQDRFMEIETQMSSFLTTAGYKRENFSFLPCSGLIGDNISLPISNPAASWYKGPNLVESLENLEPVTHVLTKPLRLTISNVFRSGNQNLVSISGRIEAGSLQVADALIVQPSSQVCNVRALELDNKLVDWAVAGQNVVIHLTDIEEQHLKIGNVICSPLNAIKNTKEFTAKVLAFEFLLPMQVDVHRGQLHSSGRIKEIKGIFNKSSDQILNKKKPRVIKPGMVARVIVTLERDEPLESPARIVLRSNGVTVAAGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFY1</accession>
    <name>A0A0B1PFY1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000113">
        <property type="protein sequence ID" value="KHJ36200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFY1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFY1"/>
    <dbReference type="HOGENOM" id="CLU_349909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062126" evidence="2">
        <location>
            <begin position="19"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="805" mass="87275" checksum="36D448526A0E4C3C" modified="2015-03-04" version="1">MFLYRLIFFIFLINSSISYPSQKRDTISIYSSIPTQNVIHIEKNFFSKPINSLPRILAISYDNLKQFVNKSINFYKLQSNPSVTLDSSLLVSSRHKKIIVGGLPSNLAHLEHSRAKSFLLKFLKFNEPSLKNVKAIDNGSMNDKSITHQTSSIKSIHVSVNNVPSIYKRGLNLKFPKWDFKSWRGWNWRLGTPRRIGGGTPNIQSVPSTPSTPNLQSTLGTQSVQENRMRRPNFGAIKNYGRKAGSRFNNGRKARSRFKNGVNVGRKRVVGPKGSRKKQKNKPQAVKDTSPAEVSHISSDKSIDKSSVQNIPVPAASQKKKLKSPEFGFDDSQTERYSKNKNNRNRESFSLPSGLSDFSDPQSDAIPKTFKKVKTPQNTQLQDFKAENYYSSSDKEKSDSSSSVPRLKKGRARKAHSKKKNNSPPITSVTDPKSPETKPENSINKIPPPVSVLSFSDEQSSDTDSKDKINSIPDDNPVGNKIQNPNEVVRFKDVQFMNQESEFSDSDIEMSNFRDGKTGNFNRPSNPQSFMRHQTNDDMPMQNFHIGEGEDYGTSTGRAIGKAIGDFLPIAHTVGNIVTGKGNMGHGAGGYGGYGGYGGGVVDDFDGMGGMGGYGGGHGGGFGGMGGHGGGFGGMGGHGGGFGGMSGQGGGYGGSYGGGYNGGSYTNHFGGDASGHGALGLGGDSMHTPDLLDETRSPVLEKTKPKSISKKIPAKTEKGVGPEGVNQDDEMENQNKSDKASEKTAHSSKSKDTHDKISDINSSKLTVDSKKNDTMTVDNENSGDTNSSHDHVKTSNSPASSKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFZ3</accession>
    <name>A0A0B1PFZ3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000369">
        <property type="protein sequence ID" value="KHJ35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFZ3"/>
    <dbReference type="SMR" id="A0A0B1PFZ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFZ3"/>
    <dbReference type="HOGENOM" id="CLU_032354_0_0_1"/>
    <dbReference type="OMA" id="DQAYKFE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="196"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="298" mass="33489" checksum="E10C6DB7D517CA43" modified="2015-03-04" version="1">MVIFMHHHHIARISKLPNSRLACQVILKSRLPNGNYYFSRSNALQSSQRNYGSGPNPNPNQNHIKVWPFIAITLLGSGAYALMVNSRTEMSASSKSSTTFTSSKTPVVFVLGGPGAGKGTQCARLVRDYKFIHLSAGDLLRAEQDREGSEFGDLIKTYIKEGNIVPMEVTIKLLQKAMIDAVSKCSDGNAKFLIDGFPRKMDQALRFEEEICQARIVLFLDCSEEEMQTRVLKRGETSGRTDDNPESIAKRFKTFIETSMPVIDYFKAQNKVVTIDARKSPEDVYKDIQEKLREKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH92</accession>
    <name>A0A0B1PH92_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative oligosaccharyltransferase subunit ribophorin ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH92"/>
    <dbReference type="STRING" id="52586.A0A0B1PH92"/>
    <dbReference type="HOGENOM" id="CLU_051361_0_0_1"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044290813" evidence="8">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="32135" checksum="DE7D6DB355DC36F7" modified="2015-03-04" version="1">MRFRDGIFFTLYVLGITSSTTASTSWNFNEAIISVAGKGYSSSKVFKDKLSDHVPLANPVKLTAADTLKITLTAVEDGITKRPHQAMLLLRDQDTGLEVPFSFSMMANGKGKVEFTQKNFPMQLNISSQPLRATLLLASFGSSQAFSNHVFNLDVKRDSQAVNAAPRYEKPLRYGKLEGIDHIFKPEPKSGPIIISIIFLVAVAGSLPVLLSSWVYLGANLSHLPQAIRAAPIAHTLFFVSILAMEFILFLYYYNWTLFQVLPVAGIISLIAIPSGPKALSEVQSRRLVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHQ2</accession>
    <name>A0A0B1PHQ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000075">
        <property type="protein sequence ID" value="KHJ36311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHQ2"/>
    <dbReference type="HOGENOM" id="CLU_1670679_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="17643" checksum="E8A82666032F572E" modified="2015-03-04" version="1">MGTKSTDSRAQENWVSRTPRTPAESLLQIEHVRNSIRATHEDANSVPLFEAMISTLKDHELPVYSQVFMSNHLNEILATNLRLSTRAKQKRKHVQKGNAGLVGEEDFEPIRVEKEAAAHQKRVEPRSGDTGQPGVRKKSAYGCVGRWATFVISAHISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIY0</accession>
    <name>A0A0B1PIY0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g0659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIY0"/>
    <dbReference type="STRING" id="52586.A0A0B1PIY0"/>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ36439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="602" mass="68696" checksum="FC9062FE6F0AE75E" modified="2015-03-04" version="1">MPTISVDKARLYEAIGQQYTTQEFEELCFEIGIELDEDTSESDRPTINDKQEPAQLKIEIPANRYDMLCLEGIALVLNVFRDKMQFPNYKLFKPGVDKIETITVHSDTMKVRPYVSGAILRNVQFTQESYNSFISLQEKLHQNLARNRTLVAIGTHDLDKIHGPFSYEALPPKDITFIPLNQKTEMNGSELMEFYEHDKHLGKYLPIIRDSPLYPVIFDSKRTVCSMPPIINSDFSKITLKTRNVLIEITGRDKTKLEIVNNIVVAMFSQYCTEPFTIEQVRILSEHNDQTRETPDLSFRTAEVEVDYINRSCGLNESPKRICELLRRMCYSACPSAEDQNIILVSIPPTRADVLHQCDIMEDVAISYGYNNLPRSSPNKASTIARALPINKLSDIVRMEAALAGWTEVMSLILCSHDENFKSLNREDDGKSAVILANPKTSEYQMVRTSLIPGILKTIRENKKHSVPIKVFEVSDVAYKCINLERKSRNERHFAAAWYGKTSGFEVIHGLLDRILLMLRSPFLVEEGPHDKVQDGSAIDGYWIDEINEPTFFPGHAAAVFIRIDGKKTRIGEFGILHPSVLEKFDLRYPVSILEFNLETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUP1</accession>
    <name>A0A0B1NUP1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005174">
        <property type="protein sequence ID" value="KHJ30092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUP1"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="171" mass="19146" checksum="34E11AE5EB3828A4" modified="2015-03-04" version="1">MSCNETDITSVNRTQTGFALTIKDKEIRQKLLNDPVNLAPLEAKLEPASNLITYIIATVPVAALTKTDRWVVVDNDRVIAKITRVTNPTPQIVRLHGKTRPSVPHHSCLAHFTREQAPQPGFRIFDESGLAYTYKPRQTIQKCKRCLGYHPTRGCSRAPACENARQPCIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVJ7</accession>
    <name>A0A0B1NVJ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative familial paroxysmal dyskinesia fpd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004398">
        <property type="protein sequence ID" value="KHJ30357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVJ7"/>
    <dbReference type="STRING" id="52586.A0A0B1NVJ7"/>
    <dbReference type="HOGENOM" id="CLU_023613_1_0_1"/>
    <dbReference type="OMA" id="WAERAHT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23867">
        <property type="entry name" value="Mmc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="1">
        <location>
            <begin position="378"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="642" mass="72473" checksum="B944067EF9010863" modified="2015-03-04" version="1">MPPLISRGVKMRNLSSQRLKVKNFQKVCSIYCNFEWSKSHLSFWRQIRGQSALNISPGRVRFISNLKPSRAQLLNTLKELNKYASSYVNQSRLQLALRGLEQKCGEETIRIAVLCVAGRNSSFQRAKQIIQLLLADPLKTQEKWEQFLLSKFSQALLLIVGPEPSVDTLKENNFVQELHVSSPLLNGQRIEILVMESDLPTNRLDEEISLEAFLVPSVKIPSSDSGRYSIIRTPVHRTLLISEGLLGAINLLKIPIDFHRRDIIETAIDFTVPDCQKSSIPSNFIDVALAAKALESFREHSSNISQFETSWSLSGLPKIQSWLQQGIISTSIGMNVYLQSLIGSLLEDTMRAIEDEEAQLFTKELSKKVSQNDITRLHEELKNWASRSHSELQDKLELAFEGKRWHKLIWWKLFWRVDDITLVASEILNEHFLLNAEQEAVFLAGRIAECGFSEGRVLAPLESCASEGIDDKISKAQLGEKPQPPQVIDFISSNGNESLLHMKNQCWPKHITAARLYLSQLKIPPLQALGQRLVIQTICTSLLASTLSGLAFISSASLDLYEVGVMASLGILFGLRRMQRTWENTRDIWKEEVREEGRIALISVEAHFKTFLTTNSNVPEFEEIKNAKAAVLATEKALLACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWN4</accession>
    <name>A0A0B1NWN4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003656">
        <property type="protein sequence ID" value="KHJ30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWN4"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="214" mass="24042" checksum="96653F448C9065CC" modified="2015-03-04" version="1">MLADEIERVSSVRPEAVKLYCYQKPDALHRTWLALFTKRLKPGFRVFDKSGISSIFKKQTPIEFCKRCNGHHFSKFCSRAPSRGNCGSNMHTQDVFIAATQCRNCGGPHRSDSRKCLARPTRHGAQTKEQLKVYRQAGDREYQAAVRARAALEKAPEMEALIGNSVYGNLVPEVNEITIISVPESPEVEEELIHTFGNVTQESVEVVTDSSMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY10</accession>
    <name>A0A0B1NY10_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003552">
        <property type="protein sequence ID" value="KHJ30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY10"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="MCFREAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="393" mass="44463" checksum="ACC69BA56ED993F2" modified="2015-03-04" version="1">MNNILNHFHYNNSYVHTIVIACPNRNLLLIHCYLKHLILTIPSTFDPCLPCSSNSDADEFGVVGLQTDNTLFLANQKFADKEENEIKKAKLIAKDRETLTKGNSLKFNGGLIHLHSNPRSITVKQKQHCKNLKLVQPHPTDILNSRGKLRKASSTHDQFVAQRARGAYTASVCQPEASFDLSSAAQAVRLNNTDINSLNKRLKWQVENSERGLRYVELDKSSIELVVFTDSSFANNKDFSSQIGFVVVLKDKENRANILHWSSTKCKRITRSVLAAELYALVNGFDSATTIKSTLERILCMQLPLIICTDSKSLYDCLVKLGTTREKRLMIDVMCFREAYEKREIAEIRWIKGQSNPADAITKSKCCNALRNLIDTNSIFIKTNELIERSPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYD6</accession>
    <name>A0A0B1NYD6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005460">
        <property type="protein sequence ID" value="KHJ30050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYD6"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="26657" checksum="88AA94C31A789F7B" modified="2015-03-04" version="1">MNTIEEILALSMDSSSLPSPIPPIAQSTHPPDPFNLSQPSQPPSTSISHNISVAKRQIREPVPPSKRTLPKISHNDSGEKMTNRRERAWHARILICTGVISNINSTLADFKDEISREEATAFQIQLRQAISKFAALDSLPTPTPPPIPSKSLQKKQSEIPNPKIPNKPKVVATPIMIPTSTSIHDPTHVTQPRENSTAQPSWATMTRNAQKKARVTKANNTKSTQVKKSLSYGTLDRAQSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYJ3</accession>
    <name>A0A0B1NYJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hit finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003304">
        <property type="protein sequence ID" value="KHJ31048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYJ3"/>
    <dbReference type="HOGENOM" id="CLU_2279530_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="102" mass="11353" checksum="E9F850682953B82E" modified="2015-03-04" version="1">MINFGVQEVSTTKLVTAPGWAYVLDNASQSPLVATQPISRKRARKPTLDIVNPRKSTVQLDIKILRELALLDRENHRDVSVPIPPKQNQDQNVGRGKGVMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYP3</accession>
    <name>A0A0B1NYP3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004954">
        <property type="protein sequence ID" value="KHJ30155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYP3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYP3"/>
    <dbReference type="HOGENOM" id="CLU_000288_17_0_1"/>
    <dbReference type="OMA" id="FKAVHIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="717"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123650" checksum="500A9DEF2C7FFBF7" modified="2015-03-04" version="1">MNHLQQHIQLRHVAMKESRSHVEDRRDRGRADRSFPGSRKARSPIPHWQEGDRTSAKTRDRSPTKSKSTSQRTHKPRDRSYERRRRISRSPELESREVVRERNRGRELLDTRGSDKPRKSHSYRSPSSSKRRRESRSPSLSRSHIKKSKRDQSKSPRLESKFRASSRQEKRNRAVSPPTPRKRSLNRSTENINSKSKRYRDSSTFDKRGRSPSPRSRQTSRRDNHHKSENSPKRIRSPDRFAHKQRDRSPIDKYKVKGYKREEKESVRGRSPEYTTSRFSRQSSPRAPRGPKSYRGGRSPLREGRGGKQAREDSRAPEKPGSVGADSGNFTLGANSVESKNSKTPTAASASGANSIEVKSDKMAGRGYYGNQHGYNPHHQMQAAFPLKPQFNQGPPQVDPRQFSHSPQHHMTPYHGSPVQSPYNSNRGNWGYHTPQQYSPPPQYTSNFQQNYTNPNNQGQFFGQSPPYHGPQTQAIHQPYQHSFRGNRGYRGSQYNPRGGRGEHRGGRIAHFKNLQWNSSTSNQTSTARVQQSNSDNATPIQTSSQKFPSISVSAQEGKTQFTSHAPPIENEEDTDELFRPSKDLQVEDTDAGKKKIEERMPPPSRPAPSGSQPQQNSSKFSFAFKGPSKSINTTPKSDISLKLNAPPSRNSEASPDRSKGSTSHSTAKDQLSIGQEDTRESLSVTREVKKVQKHIHERPKLPDEFSKSESIYFRKPGNESVVGSGTYGKVFKAVHIYTRKLVALKKIRMEGERDGFPVTAVREIKLLQSLKHKNIVNLQEVMVEKNDCFMVFEYLSHDLTGLLNHPTFKLDPSYKKHLAYQLFEGLDYLHRRGVLHRDIKAANILVSNEGLLKITDFGLARFYAKRRQLDYTNRVITIWYRSPELLLGETQYGPAVDIWSAACVLIEIFTRHAIFPGDGGEISQLENIYAILGTPNKFDWPGLVDMAWFELLRPNTRKPNVFAEKYRDRVTPEAFKLLQAMFQYDPAKRPSASEVLEHSYFVSEEPKAQQAFALSKLDGDWHEFESKALRKENERKDKEAQRQALKRAEKKRISDSDIDNNDRDVKRIAPAKDLDPLSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN4</accession>
    <name>A0A0B1NZN4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004104">
        <property type="protein sequence ID" value="KHJ30505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN4"/>
    <dbReference type="HOGENOM" id="CLU_1220474_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="227" mass="25631" checksum="8FC137864AD4E5EA" modified="2015-03-04" version="1">MTRCAARVIAGFPALDELPSKPQNKNLVNKPAQVLHTLHTQQKYRLAKRDHNDPNIKSISYARAVADENTLPDPISRMSGKNLKPEFLRSDTRIIVQLAQDPSLRIMDTFLARTKYRSLLPRPELIKDVRIVPFGIAHVASSHADDKDLLAASQFLQPMTCPAQVERQEMRHTFLLGPVPKYGLNTAGLPEPLSLVEIKNKLNLTSIDTKKCIRDELDQTLFEVYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZP2</accession>
    <name>A0A0B1NZP2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005000">
        <property type="protein sequence ID" value="KHJ30141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZP2"/>
    <dbReference type="HOGENOM" id="CLU_2122887_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="114" mass="12682" checksum="8764A4648E75C1F2" modified="2015-03-04" version="1">MIASTHKPSAAMPYRNAYNNLLNTKFTTSATDFCNDFQRNLQNFRNAAASLEAMNENSMKYGISEGMASIMFFQGTAHISWLETWRATGALEKDQQSFAPVEQMTATLRAVSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZT2</accession>
    <name>A0A0B1NZT2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="JNVN01004008">
        <property type="protein sequence ID" value="KHJ30550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZT2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZT2"/>
    <dbReference type="HOGENOM" id="CLU_036645_0_1_1"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="342" mass="37325" checksum="2F69C021EC169282" modified="2015-03-04" version="1">MSPWFDFLRPSFAGPISAKLIRIAEKPWSVSFMPQKQTRHSSHSPLAPSSDNARRKITLNTINSLYKKGEPIMVLTAHDFPSGYIADIAGMEIILVGDSLAMVSMGLEDTSEVLLEDMLLHCRSVSRAVKTAFTVGDLPMGSYEISPKQALNSAIRLVKEGRVKGVKLEGGLEMAPSVNKISTAGIPVLGHIGLTPQRQNHLGGFRVQGKTSGSALKILQDALALQKAGCFAIVIEAVPAQIATLITKELSIPTIGIGAGSGCSGQVLVQADMTGNFPPERNVPKFVKKYCDVWSESLKGIKKYREEAKSRNYPAYEHTYPISEEELIAFERELANKRFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZU5</accession>
    <name>A0A0B1NZU5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eukaryotic initiation factor 4f subunit p130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002511">
        <property type="protein sequence ID" value="KHJ31882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZU5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZU5"/>
    <dbReference type="HOGENOM" id="CLU_794990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 4G1 eIF4E-binding" evidence="2">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="349" mass="39847" checksum="54E530F565920003" modified="2015-03-04" version="1">MEMTHEVAAEERPTSRESCNPTQELWADAFGVASSNNSKTPSETNLGNNNTPKSVADDHLDYQATQIEAIDLNLNKSKEEENEVSVQEKQNEEFHPDGSVSQVESIINPTLETSEREVTSSKTQLTCDSDVKTGIMRSNKKSLTLNITTSNLRPSAALKCLESARWLTSLDPSIYPPSIKSPNPCLNQDDKGSPRSFKYDKEFLLQFKNYFVEKPCMEFESRISALYEETSKSPKTGSKYTFSNSPRCDTFTTINNEIDRVSLRPASTQKPNYIPRWDTYNVKINERYGNLGSTQRLENRTRHDHKNSRNSNKTFGMSSFSWGDNRRPVDNITKEEFESITRQWREFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P047</accession>
    <name>A0A0B1P047_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2839</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003793">
        <property type="protein sequence ID" value="KHJ30660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P047"/>
    <dbReference type="STRING" id="52586.A0A0B1P047"/>
    <dbReference type="HOGENOM" id="CLU_030988_7_3_1"/>
    <dbReference type="OMA" id="QQWSAVY"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ30660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="147" mass="16571" checksum="B0D0247CF9A73DA1" modified="2015-03-04" version="1">MDIAPFQGGIWKIHVELPDQYPYKSPSIGFVNRIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPTDPLNGEAAALLMREPESYDTKVKEYVSKYASREAADEAGVEDSDEDDMSSVASFDDDEDDPAGQMEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P070</accession>
    <name>A0A0B1P070_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004733">
        <property type="protein sequence ID" value="KHJ30224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P070"/>
    <dbReference type="HOGENOM" id="CLU_1788258_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="145" mass="16471" checksum="58CBC3121C00A494" modified="2015-03-04" version="1">MSTDPEKSTSGVSPEMPTQTISTFTQNIFRKYGLTEISLTDIDETKLGNSVIDLNNTTKGELASTIVTFISYYIDQDLYDEELFWEFKQDFSGWKRIHFDAAGILKKDLKRTLLERGIFVPSKGYADSIALEMTYSSNVLKDRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P071</accession>
    <name>A0A0B1P071_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P071"/>
    <dbReference type="HOGENOM" id="CLU_2322091_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11058" checksum="DEAE9A5005B080A2" modified="2015-03-04" version="1">MKSQKAAFRNASKNLSQSCKNSDLSNTVTTTIAKTTPRKIKKNAARNERRKAARKTAGLLKAQQQQQQSSTSKTDEEEIKTKHRLKGNQEDQKGENGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0K0</accession>
    <name>A0A0B1P0K0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gtpase binding protein rid1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004470">
        <property type="protein sequence ID" value="KHJ30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0K0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0K0"/>
    <dbReference type="HOGENOM" id="CLU_008022_0_0_1"/>
    <dbReference type="OMA" id="WERCMGG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="252"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="787" mass="89327" checksum="9ABDB49EFB81ECFE" modified="2015-03-04" version="1">MVLEEWHNYQQGQQQPARSGTNETTRKTLSKKSKSSLSLKSLSRKEGGVEEYKVPGPKQSKPMKIKPSSNFANLLSRPKSLMNLKKEAIEDHLQGQRNKENNYPQELPKKPPTPIYSQFSSQPCIIKVKDEINLYTPKDYTPRKQRDFFENGRRPTLAKRDESQPRPRSTYLPSSFSIQDISRRVSGGSRHSAELIRRVSGRKPNSERKVSTSTVKSDKVEKSNRNYSQRVINAVSSSFSSKSSKILNSQTDNFIDDDEVNKEFEAMLDRRNIPDHQRSKMRCLAMSMKKDFIKQDWAEIAAMENRKRIENNNNLDPNPTLFGTNDTTGSKTKRPRSRTFTLSKNVGINISNKNPKSEVTVIKNLRKKSSESLNGGVKIFSGAGAITAQNLIAKAKGQTPDDFVSYMIRVPKPEKVEVGRLHKLRLLLRNETVAWTDNFIRQGGMEQIVGLLHRTMAIEWREEHEDALLHEVLLCLKGLSTTELALKCLDKIQATLFPSLLSMLFDAEKKGPSEFTTRNIITSLLFTYLKTASNSEREKRAKIVLSYLRDPEPCESQRPIGFVLEMRRPRPYRVWCKEVVNVTKEVFWIFLHNLNVITLPETTHAEKDFTNEINNTTTTATATATATTHGSFELSTPSYSYMTKHFPQERAPIPAAPYVGGVEWDATNYLASHLDLINGILASLSSPEERNKLREQMLVSGWEKCMGGTLRLCKEKFYGNVHAGLTCWVAAASEDGWNTSFVRCGPRTEHECIPPKKISPKDPIPPKIALNFLGSDSKETEDKDNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L3</accession>
    <name>A0A0B1P0L3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2598</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004196">
        <property type="protein sequence ID" value="KHJ30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0L3"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="334" mass="37611" checksum="7B55965DFB366591" modified="2015-03-04" version="1">MENYQKLEKIGEGTYGVVYKARDLSHNSRIVALKKIRLEAEDEGVPSTAIREISLLKEMNDPNIVRLLNIVHADGHKLYLVFEFLDLDLKKYMEALPVSDGGRGKALPEGSGPDLGRLGLGDAMVKKFMSQLCEGVRYCHCHRVLHRDLKPQNLLIDREGNLKLADFGLARAFGVPLRTYTHEVVTLWYRSPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRLLGTPTEADWPGVMDKSCFPDFKSSFPKWIRDESQPLCDGLDEKGLDLLEQMLVYDPAGRISAKQACQHPYFEEGSSAYSGRSTNSINRAISNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0U4</accession>
    <name>A0A0B1P0U4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004240">
        <property type="protein sequence ID" value="KHJ30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0U4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0U4"/>
    <dbReference type="HOGENOM" id="CLU_033261_0_0_1"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="196"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="390"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="499" mass="56147" checksum="3D712185BA5057CC" modified="2015-03-04" version="1">MPVDYSKWDNLELSDDSDIEVHPNVDKKSFIRAKQNQIHQRRIERKNKIETYKYERAINDGFLKRIKELLVAFQSHSTESVQNPDELIFQVATESVLKGNDEKPPRPPPCVNTNENEIPSYSSMLAVLIDRIKKKIDEEKSSDRFNAYISELKSHVNEVENLQKKLEVELDTLETEASKTITSESYHTGFETSIISKPDPKPTPKKSERTQKVELLNPHAISANGENPDAQTDTGVGESSVDDDDDVEASDVAKEFSQINIKDYRAALQFISTHPDVVAEKETDGLLVMAFNFCINNEDDNARRCVHHGLLLQYCRALGPDGVGIFFKRITTPGHQAQKVFYDDVNSTFTRIKSRAKEIQNQRAQEVANGIGGVETIQLHAVDPGTTINITIPSLNSENPSEVEARKIFESFPDDLQKALESGSLDEVNKVLGKMNVEEAEEIVGKLGEGGMLSLEEQIIDTTTEEGQKALKLFQEQERAAKEEKLAKELEEKYADEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0W8</accession>
    <name>A0A0B1P0W8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative atp synthase subunit g</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004188">
        <property type="protein sequence ID" value="KHJ30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0W8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0W8"/>
    <dbReference type="HOGENOM" id="CLU_083674_0_0_1"/>
    <dbReference type="OMA" id="NMTPPNL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="198" mass="21434" checksum="50F0E3F81D1E7CB5" modified="2015-03-04" version="1">MSVIFSRSIRPCNNLHRATRNSIARFGSTDSQFAKEVAKSSPLSTATAKATDSLSRAASAAGPALKGVGKTLGSFGGKTGEIMLLLQRNIPTTVYYARVGLELSKLVIHGRNMIPPPISAFQSYFQRTLEKLRNPSSILTSASLKNPQEILQRARNLSSSELAAGMVLFAELLGFFTVGEIIGRFKLIGYKGEISHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P163</accession>
    <name>A0A0B1P163_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002143">
        <property type="protein sequence ID" value="KHJ32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P163"/>
    <dbReference type="STRING" id="52586.A0A0B1P163"/>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="124" mass="14082" checksum="B0FF08ADB2E06225" modified="2015-03-04" version="1">MADITGIAQEFTQFYYNQFDLDRSTLATLYRDESMLTFETSSVQGAVNIVEKLCSLPFSKVKHDITTLDAQPSGLHRGILILVTGRLLLEEEERPMNFTQVFQLNPNGAGSYFVYNDIFKLVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D5</accession>
    <name>A0A0B1P1D5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003705">
        <property type="protein sequence ID" value="KHJ30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D5"/>
    <dbReference type="STRING" id="52586.A0A0B1P1D5"/>
    <dbReference type="HOGENOM" id="CLU_1046608_0_0_1"/>
    <dbReference type="OMA" id="NCADISY"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="29475" checksum="282AD08671899B43" modified="2015-03-04" version="1">MSSIRNSSAARFVSTLSWGQDWEKARCNEGLLDIEFQENFNITDEHIDTITNSSTAANLRKLQFGDSDTGKGRFVSDQAIVRLAKACHNLEEVEFVSATSLTDIALLAIAQNCPMIKSINISGNDKIHGGVKGHCFDQLAANKDIAPVLTTVLLMDQDVRRKQIKLLTKQRPGLTVREGETVGDGIADQMVASLTCGGNVTEWRNGKMVSMSSDFGMGDISFDEFDDIDGLSFDSSDFDSEEDYDEEFGEEEEDDYEDNDEKKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M3</accession>
    <name>A0A0B1P1M3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative asc-type amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003139">
        <property type="protein sequence ID" value="KHJ31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1M3"/>
    <dbReference type="HOGENOM" id="CLU_007946_3_6_1"/>
    <dbReference type="OMA" id="TYWVISF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="603" mass="65641" checksum="552DF6A1F55BB6D1" modified="2015-03-04" version="1">MSQSSISNAQFHLRDSLELKSLASSDEEDFDNSFSSSLKGSLDEARPLELVTTARENDKRKQLRSQSVFSVFDFSSNLFPLSSSAGNEYTSIYNTTFSHGRSSLGAGSLEKHKNITFLNGLSLIIGSVIGSGIFSSPSQVNINTGSAGASLIVWIVAGILAWTGASSYAELGGAIPLNGGAQIYLAKIFGELFGFLFTWCAIIVLKPGSAAIVSIVMGEYLVRAVIGPDAESVSVWINKTIALLGLLLVTFLNCVSTKLGTKMSDLFMFMKFFALIGITITGVIVAATGLSYSGMANEDWKNIRWFEGTSTNVGLWAVALYSGLWAFDGWDNTNFVVGEFRNPTRDLPKVIHTAMPLVILCYVLANISYFFVLPIDILNSTDTVAVAFGSSVFGPVGSLVLALVVSASCFGALNASTFTSGRLTYVAGKEGYIPVIFGEIGIRNKNAENMQTTQRKNWFIKYIERIVGDEDTGLFFTPVYSMILNATLTAVYILLGELSTLVTFYGVAGYIFYFLTVLGLIILRVKEPNLERPYKTWITTPIIFCCVSLFLVSRAIFAEPLKTVIVLAFILAGIPIYHFRFRSKNGGMSGRGRTYTVIDEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P204</accession>
    <name>A0A0B1P204_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002999">
        <property type="protein sequence ID" value="KHJ31320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P204"/>
    <dbReference type="HOGENOM" id="CLU_088336_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="275" mass="30599" checksum="D4AEED75892655EA" modified="2015-03-04" version="1">MRYEVPHSSDTSSISNKSSYQSFSDSETMGNTYQGEDVNMVQDQSSGIVLLPPNLWSRDCLIYCPGILSEATRSNPNRVAELFATSVTSPTTLSSSEETVQLPSSLNMISRPAPPRITLYDGTPGNLRAFCSQIINQIQDPEGYFPSEISKVRFAYQCLGPGALVKMRSSFRCLEDPSAPSEINTLSQFIKALKQRCQDPALLEKASYAAETIYQGSMSFHDFITLFEDNMADSTYADLDKSQWKAMLKRRLSPELRRALLSAYNISNCDTTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P222</accession>
    <name>A0A0B1P222_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5058</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="JNVN01003384">
        <property type="protein sequence ID" value="KHJ30981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P222"/>
    <dbReference type="STRING" id="52586.A0A0B1P222"/>
    <dbReference type="HOGENOM" id="CLU_007727_4_0_1"/>
    <dbReference type="OMA" id="CFVSPAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="76"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="455"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="748" mass="83109" checksum="3FCCBF8F412B8830" modified="2015-03-04" version="1">MDYNKYATVNGSMNNRKMGLQTSIEDDDDIEKESDSLSMTKIRPVISRKPYLPTGCCYDDRMKLHANADFSADPHHPEDPRRIAAIFQHFRDAGLIFTGPDIELRLALKKSPTSFMYRIAARKATRAEICTVHTSAHYEWVQSLNDMTSAQLRDLSAKFDTGRKSLYVGNLTAEAALISAGAAIETCKNVVLGKVKNAFAVIRPPGHHAESNESMGFCIFNNVPMAATVCLRDYPDICRKVLILDWDVHHGNGTQNMFYEDPNVLYISIHVYQNGLFYPGQPEDESLPDGNIDKCGIGAGLGKNINIGWADQGVGDGEYMAAFQRIVMPIAQEFDPDLVIVSAGFDAAAGDELGGCFVTPACYSHMTHMLMSLANGKVAVCLEGGYNLGAISRSALAVAKTLMGEPPERIIIPPLNKDSAYTLDNVRRIQAVHWDCMRPGVIPFPDFKDETFQLVSEVARTAEKNVFAEEFGMVPLFIQRTISNLIFKNMVLASPEIYKAKKILMIIHDPPELIAQPDPHTNITYAQNSFISKGLLPYLTWATGQDMALISVVLPQCRPSSATFPTNPPSSLLSESDLSNISREVLCYIYDNYIEPHSPATALKPPTSLTILGVGHAHIGIRQLLISRDCRQIVTSILCFVNGSLKPVRSEMDLGLAAWYRNNSRIYINENHPVWDNDESVKSVHKMRYGDVFKAKGCNSINSMLRLFYLEATTYMARKIIAWEELIIPLLPDPDETEDEDMTDMGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G0</accession>
    <name>A0A0B1P2G0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001779">
        <property type="protein sequence ID" value="KHJ32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G0"/>
    <dbReference type="HOGENOM" id="CLU_007151_0_0_1"/>
    <dbReference type="OMA" id="ITHPMGE"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="638" mass="70533" checksum="D62D13432D7A0698" modified="2015-03-04" version="1">MHQHPRPPPRTASPASSPKTNPTRTNNSREEYTGAASRKKSVDIHERKKNDTDTMSHHNSPSKDALKKLDQIIQNFHIKAAILVLQSRISLPIVITQEGTKKVNKWFQIETDDTNLFRQELSIWKQCGSYSDRPPPLIIETYIDASGLNRSQSLVLVSDTGKRWDALGAFNNAYGEDLRHSSRCCEIILERWKFELRDLPSEDVYDFGSTLPTIYKKFIVFFRSLYATTKFVPAGRLIRTLTKNCSVGSPIKINCRILNGKAPNSNFDPLTFPIFDNGKIPVTTDYVLGTTETPVGQVYAVVSYRQDCDFRIDDSEALLSSRFMGADEYIYQPSPGHKGSDKQAYHATESTSVPFNRHKTYGQSLNQTCDSSSISHVFTISPESSPINTQRVMKNHGPELELSPYEPIPKSRPMHVSRNSINFIDGNIMARRTSVSFQPFKAGSLSSSPSYSRPAQSGDNTTPQSSQSSPRFSGGVALVQSRSRSTLNAGSPATLRGGPLASEPGTTLPASCSPKPAPTSRYSSSFKSRRGLTTLSPGSRSTVDDDQNSSGKQSSSSSILPGSITLDTRIGGISESLQCDDNNISEFLKVLERQKTLKSFENTSEMAAKRMSAQLSKYQSLRESHNALTESMSSCENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G7</accession>
    <name>A0A0B1P2G7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nap family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002042">
        <property type="protein sequence ID" value="KHJ32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G7"/>
    <dbReference type="HOGENOM" id="CLU_038163_0_0_1"/>
    <dbReference type="OMA" id="RFTFEFK"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="36628" checksum="5EB9CFD4061FEDE8" modified="2015-03-04" version="1">MLNSLENSSVTYEDLAQIEQEFEDVEKEIIRQEITLSSPIYARRNALISKIPNFWPLVFEQAPPEIDQHIQMTDGALLLGALTSLSVTRFEPEVDPRSVLIRFEFSENKYFENKVLEKKFWWRTARNRSWCGLVSEAVGIKWKSPEVDLTEGLLDLVLAAESSVATKPPSDESARKDKSTPILTDAQKKLQQCIQDKGINGLSFFAWFGFVGNRISAKESAEAEASRRNKSAVQSTGADEDINEGFDDDDDDDLEIFPDGGELAMAISEDLWPDAIKYFTQAQEQDTISDEDFESTDGEEKAIDYEFEDEEEKSRVAKKRKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M6</accession>
    <name>A0A0B1P2M6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nad nadp-dependent indole-3-acetaldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003153">
        <property type="protein sequence ID" value="KHJ31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2M6"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="OMA" id="AWKAMEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="300" mass="33595" checksum="8859920BACA16928" modified="2015-03-04" version="1">MSTIEARIDFAPNFKLNNGVEMPSVGYGLGTARYKSDPSAPVDTELVNLVVKAIKAGYYHLDGAEVYGNERELGDAIAQAGVPREKLFVTTKISGTKVQNTQAAFDLSLKKLGLEYVDQYLIHAPYFAKTESDLQQKWADLEAIYTSGRAKSIGVSNFLQKDLEVILKTAKIRPAINQIEYHPYLQHGELIPFHRKFGIATSAYGPLTAVVKAKPGPLDSIYDELAKKYNVTPGEIALRWVVDQGVVALTTSGKEERLKQYQKISQFKLTTEEISLITEIGKKKHYRGFWREKFAEDDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N6</accession>
    <name>A0A0B1P2N6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N6"/>
    <dbReference type="HOGENOM" id="CLU_036943_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="435" mass="47951" checksum="465F697288339678" modified="2015-03-04" version="1">MVLSTCDKKSGVSETLDPKSRVQKPVKNAGRVQPLAAVLTRSAAKTNAVVEKIAAVQDTHAVATQFEQSPTLAMNIDAKSESELKSEPEVDDFPLLPFAPLLKRTFESLILLDSIYNIANNQAEDPPPQNSNLMKKAGGHLNLVGPYLEEMEIDCPEAGAGYLVLISEGVSRAIRGEEIFPKTSKCADNMPSWSKFKKSSWATTAVNGHNNAAINLTQRLPRKPSPPQGQSHEDRRVMVRLNSEHEARKTGPFLLRQQIQRMIPDPSLVADAIMVPSGVAILAPTPAKAATILQYKEIIAQRIGNSVVERQESWITSVIGPLPKHVSTMDSPQDPLERLLLQEPGFASIRDEVPIRQMAWTRRSKESPEPIGHVRVNVPETKANKFPPRLQLFGAAIGIQRIRERKPVTSCEKCHGFHSTRTFAHQPMCNICGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2P3</accession>
    <name>A0A0B1P2P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003457">
        <property type="protein sequence ID" value="KHJ30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2P3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2P3"/>
    <dbReference type="HOGENOM" id="CLU_029043_1_0_1"/>
    <dbReference type="OMA" id="YAIRETK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="476" mass="53446" checksum="77D54E32A89C6CBC" modified="2015-03-04" version="1">MSSSWFPHGRNTESGWKLDIVSLLAVIGESSMDSHIQVLTSSWYCILPRIIPAPQALLKPTRPTRLPQINAAVVGVHSGTFVPTLNYFPEILHPIDDLPAFSFKVLQITHKERQPNPERDFVQAESRGNHETDRILEGSTIDPRTLENRNKIPSRRSTLRNLKRIMTGQDGRPRIPARKISPLNVVTVLTFLWTCALIIWASFLHDGTAILALITISMVSSVVGFASWWQPVLMNRPSKSKVPDGDVVIRTREGAFLLVKCNEDVARELYTGTEECLYYVTTEGYRTLVGFGTVLLMISVVLLGNCGITMQAAIGISYMVLNGIFWAASLLNPTSFWDLSYYQVEDITPKDSRDAHERTVISTDFGGITETQEQLPSFTRTMWYAIRETKKIGWVKTSGAAPRTPEWDEWLRLAEQHANQGNRGWSAVKMRGYIVEKGIKATDITRVASPMHTQDYSTAATREQIPAFEVPPHGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2R8</accession>
    <name>A0A0B1P2R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized thoc5 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002719">
        <property type="protein sequence ID" value="KHJ31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2R8"/>
    <dbReference type="HOGENOM" id="CLU_082754_0_0_1"/>
    <dbReference type="OMA" id="HKYMKLP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="24094" checksum="744B4B4BFE39652A" modified="2015-03-04" version="1">MAAQEIMSDPTLKLALEMSKHTKEQTIRLLDLIASHVSSSPPTYDFQLQISKQRKLLLTMLAQLRGLHRDAHFEARETKALTAEARQEVDKLHLQLQNLYYEQRHLQGEITACESYDHKFQQLPLIPVEKFLAEYPEHANDDEASLTIARIDHEHAERLKLEEQRQGLLKKKQGLIADNKKRKDDLANLDKDLEKFIDAAKPIQKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P322</accession>
    <name>A0A0B1P322_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003282">
        <property type="protein sequence ID" value="KHJ31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P322"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="ARANCES"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="539" mass="60136" checksum="F0BBEB838CE0DCD2" modified="2015-03-04" version="1">MPAIRPKRTFTMIDIAKDRARSRLKRKGLSQNFINLENMENDLREKGDGTPDIEMIDEHIDKLIAQGLKDSIWAKEDTNESITSTPIEETDSHACKSNQPHQRNTERNKMPEETTRKTSIAPSHPQAHDLRANITQRSENSPEKAPEAHDVPPELRKIIEAEKRRAAKITANLRTCTIAINGVQMALSTDGADGNKEFSQGLLIYLRAAIAQFMANGPGTTLPVLPSKPTQSLQVKQKEKSALPCNKALPQKLRNTEEKTWASIARKGNQVTPAIPTLSAVPSSTQKHLRADREKGKRSKPNTCDDRLFLRLTKEHEWRPLAPSAIREIICKHLECSLTDILLIRRTATGLALTAKDKETRQLLLDKSSMISTQNATIEPASDLVTYHIPNVPVAIQFPNNKVFVTKDMVKAEIKRVTQASPTTVRPHGKTKAGAPYQAWLAHFPRPHAPRVGFRIFDESGLALVYKPRQNILQCKRCLGFHPTRGCSRALARANCESTMHLTTKCKAPTRCRNCGGPHKSENRNCLARPSRSGPATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P376</accession>
    <name>A0A0B1P376_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf167 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002953">
        <property type="protein sequence ID" value="KHJ31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P376"/>
    <dbReference type="STRING" id="52586.A0A0B1P376"/>
    <dbReference type="HOGENOM" id="CLU_130694_1_0_1"/>
    <dbReference type="OMA" id="TIYIHCH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="121" mass="13192" checksum="0398553C88C69427" modified="2015-03-04" version="1">MVTSPKALRYVATSNKRGFVGCIYLNCYIKTGVSAARHGILSVMTSHVSIGVSAKPRHNQANKAVGEIISQSLSWPRSDVEIIKGHKSQLKTVAIKGVVINGEEDEYLAKIRSKLEQNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P391</accession>
    <name>A0A0B1P391_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002940">
        <property type="protein sequence ID" value="KHJ31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638086_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="97"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="430" mass="48862" checksum="3C95C94EAE77BC05" modified="2015-03-04" version="1">MDKKGIVLNNLQNYIVDGNGKKIPISRRFGHPFMMWGPMATSNGYLTETELRTLHRRFGHPSAIKLVNLLDKAGHEDPQHRRLLENINKHCDKCQKYAGAPMRFKFTLRDDVDFNHSIFVDVMYIDGSPILHVVDEATRFQAAKWLKNMSSSHIWNMLRACWIDVYLGPPDIINHDAGTSFTSQEFRQYAMSLSIKTKEAPVESPNTISFVERYHTPLRRAYRVIKEEIGANDSDEQKAITLQMAIKAINDTAGYDGIVPTLLVFGAFPRISDMDPPAPSITKRAAALKKAMVEVSKIRAKRQVTDALQTRNGPITTDIPLGSDVLVWRVHDNSWNGPYKLLAISGETASIEMPHGPTAFRMTNIKKFDNPHNPHYEQQNQEQNSQSQHVPPIRRQPTRNAGLPARYRDEINLXXXXXXXXXXXXXXXXY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3H4</accession>
    <name>A0A0B1P3H4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative magnesium-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001810">
        <property type="protein sequence ID" value="KHJ32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3H4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3H4"/>
    <dbReference type="HOGENOM" id="CLU_071162_0_0_1"/>
    <dbReference type="OMA" id="GVWAWRK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="191" mass="22037" checksum="C6D3AEB9EE027909" modified="2015-03-04" version="1">MNSESNFAAPKSFSDGGILPKMIIFDLDYTLWPLWIDTHITPPIRSSSNHDGVRDATGQTYKFYKDVPDILTAIKHCGIKIGIASRTSAPDLGEKILNIIHIKSKNGESKKANEFFDYKEIYPGSKITHFKKLHQSSGISYREMLFFDDERRNKNVESLGVTMYLLEDGMSINEFDNGIRHWRQRYRTIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3R0</accession>
    <name>A0A0B1P3R0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002419">
        <property type="protein sequence ID" value="KHJ31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3R0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3R0"/>
    <dbReference type="HOGENOM" id="CLU_006204_0_1_1"/>
    <dbReference type="OMA" id="WAYSNRN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="629"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="411"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="690" mass="75643" checksum="24617F668F8C34D0" modified="2015-03-04" version="1">MKSSKLTSADPPNGGRRFQPPRLTRNNPQRLSVFGSRSHGNKASVRTVPEEAPPIEIFPAITHFADAISAIPKELIRHFTLLKEVDAKIFIPEEELTRLVNDALNIPPAQYSQNKEVKCKNMQESASVSFQSGLSNPILNGRGGSTYITSDNDTVWEPANFNRRKLFNQCTMSMQGMLVSLDEKNHVISTAAEALAKQLARIDDCFPFIELEISEEARNGSKTHWAYPENRISKSSNGGTSGREQHTSSQSNNVDQTLGEDSTNRSDSKKQAIFDKRKGRNQNTECDLIDQTESKQKDRKSIGNSKVRKANDSAVGLAVGIAQNNTSSNNHSKRRKVEKGSINGANLERLTSLSCVNGAKTSRGRPSSPGNTPPQPESTKKRARALPTASNGLISRKRQIVTTSAALLSLSTSPPLSKNVPGAKTHEKKSPPPSTNNGRPMTGRCRQSSVQSINEKKSISPSKNKPNFNATPDRKSTTAASENSKRDAESFIKRVSPATNSQGSHEVFDKMNPRKISGSKSSSKETISAQRESYETDQDSLADLQSSNFTTTKSGRASKPSTPSTSTFPETSRSRVTRTPLEIVNSRRSHKKGAGMISHVATTQNMDVDDADKKQKSFEDDVDLDVDEPRYCICNNISYGEMVACDSKGCKREWFHLACVGLKTAPKGDATWYCEDCKDTAKGKRSGNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V2</accession>
    <name>A0A0B1P3V2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative telomere silencing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002729">
        <property type="protein sequence ID" value="KHJ31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3V2"/>
    <dbReference type="HOGENOM" id="CLU_004908_0_0_1"/>
    <dbReference type="OMA" id="VDYNWTR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="728"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="915" mass="102861" checksum="D8088FE976046DDF" modified="2015-03-04" version="1">MKTSSRPRDIGVPYINSRSGHISQLSLKETSHHVTEAIGEIYGENNYSKHEARLLGSNVPPRIEVAEPEEPFFDPRTFSWAGAPDIENGNISNYFKSSIMSDTISTSSFEAKKSLQHLPSSNATSKALFNSTDVSYETDPAEFAQALSDLQALRRMSIDAGSTSDPDLLPLYGTFRVPSIAPTGDDNDDDPSRLFWVPARVHPELAPTEFKTFLEYKYEQIKRLAGEPTSKSMVGIQRNVSSSDPLRRKKSLLSRQLDNSFSSSSLDTLGRSGSKDSTSQQSVQGVDLKELEALVRNRSEAMRKLTIEVNGFQSGLEDTNGLQDIPILPQAPGIGLRRSKRTNYRRGSFRREDRANFSKRAGPLRKDESGSENSSSPIEENSSTSPSDQLVTENFSHPVRGARRLQNSPHSSSDVNPSTIINGIGSSDNEKNSSICSSTSTQINTNFASKVPRRSNTSAQDTRPDPPQRSKTTPLERNTVPKIIETPPLPEQQSGSAAARQLNFFPGRSSSQAQQSFQKGSTSTDPGAHLSKNILASGPQTAQINVTPQLNIVEPSAITTSLVDGNSRTDSLTFIPTLDVKKSDKKSKKEKDDSESHVLKKTSWSWFKGGEDKEKKEKKKDEEREGKKNKKVSMEKIHDNARLDVLQLTLENGAANGRESIVIDRDNLEPRSQDEKRKEARKFSTEKKEKDSIFSSIFGGGKKKGDRDSNAKKGSSLRTLSPEPFRYLKPDVDYNWTRFSILEERAIYRMAHIKLANPHRALYSQVLLSNFMYSYLAKVQQMHPHLQIPQSAQQKKQEMERRQREQEQQAVQQLLEIDQYRYDYHEGITKYAEGDQQTDFKSERVNYVDESQTYDYDHQQEKNSICGQRSSRPQSRASQHTAENGHKNESQYEQMGNVYFQAADQKISQDEDEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W1</accession>
    <name>A0A0B1P3W1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002391">
        <property type="protein sequence ID" value="KHJ32035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W1"/>
    <dbReference type="HOGENOM" id="CLU_1929151_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="131" mass="15182" checksum="2350F415E953FD4A" modified="2015-03-04" version="1">MTESDPAILYTATVSPSVFEDTVNLYEELQKRQKLRSLSDMNTAIVAQQVLSTRQMSRIANRWLYDTSADVHTNCRENLIPETIVEIMPGQFPVQTGNGVVHTECIYIYIYIYIHDRRLFLVIIYNHRALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P450</accession>
    <name>A0A0B1P450_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eka-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002648">
        <property type="protein sequence ID" value="KHJ31696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P450"/>
    <dbReference type="STRING" id="52586.A0A0B1P450"/>
    <dbReference type="HOGENOM" id="CLU_047729_3_2_1"/>
    <dbReference type="OMA" id="VQMAQTN"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058900" description="Eka-like protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="21092" checksum="6CAAF1C4AB3D929B" modified="2015-03-04" version="1">MLFKTVLASFAAAQLVAGHGAIVKAVGDMGGNGSAIGIDASTPRDGTRRTPFQADSTRFKNVNPDACGETLGGGPNDPTSQVAKVAQDSNGLPMVSAGGMIMMTLHQVNGDGAGPYSCMIDSTGTGTGGWTKMEVATNVPGKNSRSKAKATDFPLTAKIAADQTCTGSMGGMDNVCMVRCNNAANAGPFGGCVPIQMMSGGAGAGAGDAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P468</accession>
    <name>A0A0B1P468_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ran protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001410">
        <property type="protein sequence ID" value="KHJ33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P468"/>
    <dbReference type="STRING" id="52586.A0A0B1P468"/>
    <dbReference type="HOGENOM" id="CLU_000288_172_3_1"/>
    <dbReference type="OMA" id="MSPECID"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="543" mass="61302" checksum="FFDAEE3E9573B7DE" modified="2015-03-04" version="1">MYQNDYTQHSFPTWPIAVQPIPNFPPSPESRIGTVLGKTLELKKLIGTGSYGVVYLAVDNKTNACYAVKALNKVTSNGLPLDERQRKFQLREIHLHHLASSHPNVVSMYKIVDEPDCTYVVLEYCEDGDLFTNITERGKFVSDDDLIRYIFGQILNAVEFCHNLGIYHRDLKPENILVSNNGAKVLLADFGLATLDAISEDHGCGSTFYMSPECIDKSKKVKFHCGPNDVWSLGVVLLNLTCGQNPWKQASLDDSTYRAFLANPGFLQTILPISDGLNKIIQRIFDCNPQYRVDIISLKNMIRNCKKFTGPIKSALPRTPVGMGRFDQNVNYMEANYYCPTNTILNIDWPNFNYPADKTKSPQDFAILVNQLDQISDLETAGKYKKQGYVGDLERYCDGITNEDDTDLSDSASEFSDITNESNNEVVQSKNSQCSQSVLSSKSDYKAENSPVFTQLQYNFALNGLNYFDNLSETPNQDSKKPLFTSIPSDFGHVPYLSEKEIDDQQHIFLYYDSYHGFGSGQTYGMSQYPLENYWSWPEPGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4A6</accession>
    <name>A0A0B1P4A6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0045</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002620">
        <property type="protein sequence ID" value="KHJ31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4A6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4A6"/>
    <dbReference type="HOGENOM" id="CLU_017171_2_0_1"/>
    <dbReference type="OMA" id="MVHFIGP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="785" mass="89485" checksum="482D62B75DBC41E8" modified="2015-03-04" version="1">MISSMISIVFALAKTPQGGLFCGLLLLVNALLAQLLPSSWSLQLGSKLVNAEFSEAQLPATLSFSSVDRALINLKQFYLHHYLPSENNSKGENFELQFAVSDGRFEMSSFKEDVYATLLLNDLYLPGALVLAHSLRDAGTKKKIAVLFTPENVSTYVQKELLNLFDYVIPVERIENEFPANLQLMNRPDLHCTFTKIKLWKQFQFRKIVYLDSDMIALRAPDELFDLPYPFSAAPDIGWPDIFNSGLMVLSPNEADYNALFSMAQKGVSFDGADQGLINMHFGNRFHRLSFTYNVTPSAHYQYVPAYQYFKSDIVMIHFIGQHKPWLQGRCKKSGSTPVDEMLNLWWAIYDQHCQKPSESKEDLSNEADNILSTHENFEYIPKEIDFISNNAPVYQANVQIKSETSSKDLESVNYKEKFAEQFAGQSARQEVRQTTEKTLKQPAEQAVTHVIKQSVERPDKIEVGHPTDKLAEQSDEQSDEKSAVQAVKQSADQSAEQTVRQSNEQPNETIYKEVNSNHLSNFCEKNRSQRDEVPTWDGRKEPPPADSRPEALNLPKTQYAMSSDPTLFKAPDRYPDPPSNMWFEVPKAPTHQKLSPIFPWEINAEKPTRVFAMDDENLLHLQMKSEKNSKLGEEVQNNDSKKAIDTIASSIPFQSMNWKSFTRVNAWDNVPEIKQYVGTLRVHNQRQIFDHRKEIDVDPQAESLNQSIFSYNKEKHILPVTPAPLRSSKLWVNDKYISQSPATQGVPSQEEWDSKAALEHLVYHQLKVMTGNIEKSSTLDREIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4B4</accession>
    <name>A0A0B1P4B4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative developmental regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001615">
        <property type="protein sequence ID" value="KHJ33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4B4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4B4"/>
    <dbReference type="HOGENOM" id="CLU_022491_0_0_1"/>
    <dbReference type="OMA" id="MHESTAL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="107"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="383" mass="41994" checksum="3A6005639189A5C2" modified="2015-03-04" version="1">MNSTYTQQQQQHGPPPCHHGGIRQDATYRSGTTSTANSTAYPPANSMPLPTQSHNISLPYATGPYIPLASSRTPIQESVHNSADVLASLPPGGQPAPLPESMPTSCEQNGKKYQLVVVQQPQRARMCGFGDKDRRPITPPPCVKLIVTDLDTGKESDFNTIEHGMFVLNVDLWSADKKSEVNLVQNYNSQATYSQSYGQSNGQTYPSPNGYSQPPTPQQIYFNTSGQLSPYPSRSYSSQDSNHRIHINNPAQGMFTRNLIGSLAASAFRLTDPEDKIGIWFVLQDLSVRTEGDFRLRFSFVNVSEISPPPCTQNGTNGLSLNKGKSPVLARCFSDVFSVYSAKRFPGVVESTPLSRCFATQGIKIPIRKDAAKGEKEKDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4N6</accession>
    <name>A0A0B1P4N6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002512">
        <property type="protein sequence ID" value="KHJ31881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4N6"/>
    <dbReference type="HOGENOM" id="CLU_644351_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="426" mass="48139" checksum="C8DE872DC26F41C1" modified="2015-03-04" version="1">MMDTTLVTFMVRTSSSTHSVDLLGSWDNFTRHYHMEPESRETKGHWRGCHQFEDIICDGDGLSGSKRTGGLKMGTKYYYYYELDGSIEYHDASKPFTTSCPFLPGQPINFIWVPVEVPPLRDGSASMSSLRSEDLKTTNPTDKYVNLRSRSVSATIPRSYTSTSILHKRHSSLLSPNLSTTTSRLNLKKKIFPNLARKCHETYMSRRLQYNVNPPKPDMVDMNRLQYEIHVDDHSLRPSSRRLTSLSSEDSDTPRKLSTLNSPPKESQKRARFSYLFPKFPIKTKKRSSSLASDSLHCCSSSSTSHSSLSSLTHRNSLVSTKSQLSFSPTTAKDLPYTSCCINSGKSSLQNKMCMNDPDRFYLSSSNYCSRPIISKNESSWQIKNVSDSKKFDGNLVADLDFLKEGISNLDSLKIEVGYLRDLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4S5</accession>
    <name>A0A0B1P4S5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor tos4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4S5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4S5"/>
    <dbReference type="HOGENOM" id="CLU_027207_0_0_1"/>
    <dbReference type="OMA" id="RDRVEIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="511" mass="57040" checksum="A4983D707704C2BB" modified="2015-03-04" version="1">MSALSRCPPGKTNSLPPPESSIKGLKRSAPALLPAFEPFSSSPGYPRPSKRQAFAPSSSNENRNTTYPTPIPSSTTGILSSSPPPIPSTQNEVQHPSINKSNQLSLSVVPSVLVPENGNVIRIGRSSKSSDFQLSSSRLISRVHVEARYIAATAPLEPNTIEIKCKGWNGLKVHCPGKTWQLSKNDTFTTETEFVEVMIEVQDTRVLLAWPGRDQFNLIDSHNNFFDNDKTPSRCRNSHTAHSNIPPSSPILYNERIEYPISPSPIRHHTICQFLDKLDAIETAEAQVYEDLAATSEEFLVNDLFASENRSSSFHISEPNANSELSDKVSYISDDENVPLKHSLDHSSSKFDSQIISIITQDPIVSTSECLSPTLSIRTATSDFTNQSEISNHSINQLAYSLKSSLPLSQIFFKLPSHLKESYATHQDILDDKPFTKIDLQHILNLTKCIGEISREGKDAAGKPLESEYYYILEQDHDEARRAAVQSLRKPSLRSCRKKHKQYYWRKPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P509</accession>
    <name>A0A0B1P509_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001495">
        <property type="protein sequence ID" value="KHJ33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P509"/>
    <dbReference type="STRING" id="52586.A0A0B1P509"/>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="56027" checksum="7FCBA56E06790C8B" modified="2015-03-04" version="1">MIIKKCLFDQRCNLTLNSRLKSQDVKVIDATVVKNDHGPIKEYDLRVAAGYLRNDNFQRGIVQELQRLHDELQVYKPSRVSRLKIKHSEQLHMSLYKKLSSILFKHSEVENALAVAGHMPKGLYLYGDVGCGKTMLMDLFYETLPAKTVSKSRFHFHNFIQDAHKRIHKIRLKHGNDIDEIPLVAAEIAEMGTILCFDEFQCTDVADAMILRRFLETLMSYGVILVTTSNRHPDDLYRNGIQRESFIPCIDLLKNCLSVINLNSGVDYRKIPRPSSDVYYTPLDSHAISHAERWFKYLGDFPNDAPHSESKTVWGRKIFVPRVSGRSAMFKFDELIGRPMSAADYIELTKSYDAFIVTDIYGMTFQERDLARRFITFLDAVYEARAIVVLTSAVEFKQLFLSRDEVKERKIIQEGNEKTLTTGEEVEDSMRNMMDDLNLNMEDIKKSSIFSGDEEKFAFSRALSRLSEMGSQEWVNRVLMRMHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5I8</accession>
    <name>A0A0B1P5I8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001958">
        <property type="protein sequence ID" value="KHJ32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5I8"/>
    <dbReference type="HOGENOM" id="CLU_1876976_0_0_1"/>
    <dbReference type="OrthoDB" id="10551997at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080497" evidence="1">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="136" mass="14423" checksum="71C007116621D2A5" modified="2015-03-04" version="1">MRFNLLTILFALFLAIVAQEAAAPPPDDFITKTQTSTTTLTYTVTVSLIASVTMTPPLHNITLQTGAYPTATNPSLSLGPFPTDTKPDTITPGKDYNIPTPPKETSTFVPDNSARYVVGSKALIGAAGLLTILAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5K5</accession>
    <name>A0A0B1P5K5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001947">
        <property type="protein sequence ID" value="KHJ32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5K5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5K5"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OMA" id="FPEGCFQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="473" mass="52475" checksum="FCC163E7FEFA8CD5" modified="2015-03-04" version="1">MIPKDAEMNTDVVVAISPLTNEPVAIRKCATEEDNQRASRLARDSFLSFSKTSLAERQQIIKNSLRILEARKDVLAQELTEQMGRPISYTAKEISTAVNRAEYLLKISEDVLQDTPGEAEKGFKRYIKKLPVGPVLIFFTWNYPYLILINSLVPALLAGNSIILSPSMRIPTIAERISSIFNESGLPNNVIQYLNYKTLDGATSLIRDMRISHICFTGSVASGITIQKLAAERIVSVGLELGGKDPAYVRSDVDIAWVAEEIVDGAIFNSGQSCCSIERVYVNEKIHDKFIEAIQKVLSNYVMGDPFKKETNIGPVVSKQSKELIESHINDALQKGAKDSTPENETFKTFPPLGNFVKPTLLTNVTHDMVIMKEETFGPVIPVMKVNDDAEAVQLMNDSDFGLTASIWTADTKKGAELAQKVDAGTVFVNRCDFPSPDLAWTGWKNSGKGVTLSKFGFDQFVKLKSFHIKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R8</accession>
    <name>A0A0B1P5R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative stomatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5R8"/>
    <dbReference type="HOGENOM" id="CLU_024949_4_0_1"/>
    <dbReference type="OMA" id="KFGRFER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="92"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="39175" checksum="DD3188EBCE7BCCB8" modified="2015-03-04" version="1">MSSQLKSDLTSSKNGIGSMSRGDDNLSNPRLQDQSRSNIQSIKTQEIQPRYAHIYAEESDEGSHSWYGKMIGSLGSCIGTLGAIPCCFLFPNPYKSVPQGNVGLVTRFGKFHHAVDPGLIKVNPLSEHLIEVDVKIQIVEVPQQVCMTKDNVTVHLTSVIYYNITSPHKAAFGITNVRQALIERTQTTLRHVVGARVLQDLIERREELAQSIEDIIEDVALGWGVHVESMLIKDIIFSNELQDSLSMAAQSKRIGESKIIAARAEVESAKLMRQAADILSSAPAMQIRYLEAMQAMAKTANSKVIFLPGSSTLGIQEQLNAAPKINHSVLAADENLLSNLRDDLRQVNDAFSLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R9</accession>
    <name>A0A0B1P5R9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mhyt domain signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001896">
        <property type="protein sequence ID" value="KHJ32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5R9"/>
    <dbReference type="HOGENOM" id="CLU_008375_2_1_1"/>
    <dbReference type="OMA" id="VFQWIFR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="707" mass="79920" checksum="D7228D5A1F28030A" modified="2015-03-04" version="1">MGGIAIWCMHYIGNQAIILVNGQPSDQIKYNLGFTILSFILPITMAFLAFVTVGTDIKSVARVVMGGILNSLGILGMHYMGQAGITNYQCSYQFIWILGAVILSFISCTAGLSQFFLIRLSWKSSWWKRAACAFLIAAAVSIVHWLSSIGTIYQFHIASLKPMNKSYQIGTVIVITALSILGCLILVGIGIVAQRRKKKLTKTVQQLVLAVAIFDQNNKILVTSTGDLPLRKLTETWLERNSFDEFNIAHPVFLWMFETSQNWSTIVKLIPAMRAHIKALEIKKFQGINNILMGNDGIPINEYSSVFEELFCIKSADLANDLGQPLERIGILFDEIINTEQIPVKKHRIGTMEANASGSIVDLENEIMGFHLSGKGQIIFLVNRVGLTEAQRMKAAGYRFANVANVASILATKLQVNGKTLAYFIKMMQNHTSSNYLPGPGVYFSIFAIRASINYRGFEILARRDAKTQLPSVKVDIKATKDWHIKYLKTLKNMNMVEYMNHLFQIAGSRDSSYSKKKFAKTLYTSLKNLRKNINDVMFDHSLVAENLLEILFSHSINGSGQEKAFHVVFRIFLPIHKHSPDERLIFVPLDFFKTAQQIDRYSRGYEKNTLNYLSMPKSTNLCPLTNNLREESLEIPEELLESKHETDKSRHSANDFNNIKMSTYSSLPYDSSVEERLTRANNFVDELFESTLRMRKTQSQVIQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5U2</accession>
    <name>A0A0B1P5U2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002214">
        <property type="protein sequence ID" value="KHJ32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5U2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5U2"/>
    <dbReference type="HOGENOM" id="CLU_077747_0_0_1"/>
    <dbReference type="OMA" id="CARPGHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="363" mass="41255" checksum="08D9ACD5DD04D4BF" modified="2015-03-04" version="1">MVGIADVDMTEEGQYYQAPEAPISSTGSSEPAPSWVSHLIRLLTQLIRSHPTQSNTTMPDHKPAHSQPHPEKFSGLDPTCFPQFRSLLEAKLRIDGRAIGNEEERVWYGYSRLSDIASRRIHPWIEFAKSTNNFTVENFLERLDKAFGDSEKITKAINKLNSIRQGNHEFRTFLQDFEQTISEAQGWGWEDRIKKGYLRTALNRELSDRLVSQDEPVGYEEFVAQLHRTADKLEIMKGWNQRRQRSQGIPHSSQKAPYTEPAGDPMDWEPTQAVNVALAQHSNVRRTQPSSNRAIWVSQTEIGRRISEGLCIRCGGRGHRIRDCTMLPALDPNRMTKSKPIRPIVSAVAIPVEEEVENFSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5W7</accession>
    <name>A0A0B1P5W7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0434</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="JNVN01001056">
        <property type="protein sequence ID" value="KHJ34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5W7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5W7"/>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="92"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="333"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="540" mass="60642" checksum="F4031CE2751E1E8F" modified="2015-03-04" version="1">MILITLLSFFPIGLLLFGSILAVRAGRILGNLILKKNHARRSKLLQIFADEEKEFDHLGNGNRDSDEWENVEGYTMEKTPSSAIIDMEWDGIVGFFHPFCDAGGGGERVLWAGIKAMQNRWPKAKFVVYTGDQGVEKETILNHVQSRFNITLHAPSIQLLYLTTRSWVLASSWPHFTLLGQSIGSIVLAWNAFSLLVPDIFIDTMGYAFSLAFCKFLFPNLPTGAYIHFPTISTDMLSSLKSTSLSNIQGLNAGRGLGVLGFGKRIYWHLFANLYSLVGGSIDLVMTNSTWTQQHIMSLWGSWRSWVKKTVPQTVYPPVAVDEIVSAIKISDTSEKKRKPIIIYLGQFRPEKNHRLILNSFAKFKRSCTSVSKVAKLVLVGSIRNDDDIARVNDLKVLTNQLDIVDSIIFELDVTWPDVLKWLASASIGVNGMWNEHFGIGIVEYQAAGLIPVVHNSGGPKLDIVKSSEGQPTGFYASTAEEYAACFEMILDMSDVEKVEMRQRVRKNTQRFTEEVFITEWIKQVEKLVDMSKSSKMKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P633</accession>
    <name>A0A0B1P633_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative trna a64-2-o-ribosylphosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002304">
        <property type="protein sequence ID" value="KHJ32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P633"/>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="OMA" id="PVFWANQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="341"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="460" mass="52255" checksum="C3521705F4A73933" modified="2015-03-04" version="1">MPLTTKDLIFPEQSSHNFGKTLVELRRSNLTIRNRLVSIHHDSHFAEQIFAKYGRPLIANERCGSWYVQPKIKVASAYFKSTDGHTGVWKFSVRRLNLHLLEIIGKNDGCIIVDSTRRGKSMPDALIKTVPIWCAVLNRYIFPEKSTWHSLHCPPQLVSPSEFDQINSLLPYFVTNLQSLNISPIQLRKYLYKPLRPLWVTPDSVFSDEKLNFPDFHPVICCTVSRHIEGGELSASGYIQGAGDDTENWAHGLTPELFWEKIEELLLISNSDLPDYIEKLVLVQKSSSKCIKKEMRCIRPTSCLFITSISELDDTTTCPNSCLILLLPDSKENVILNNKIMIGIGREKLAARNLRKTLPLITNFVASKVKNKNIKLKNNENNFNIIVACETGKESSIGVALVILCLFFDDDANLMEIHRDKRAINKSFIKSRLSWISVSIPEVNPRRATLQSVNNFLMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P683</accession>
    <name>A0A0B1P683_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Er lumen protein retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001801">
        <property type="protein sequence ID" value="KHJ32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P683"/>
    <dbReference type="STRING" id="52586.A0A0B1P683"/>
    <dbReference type="HOGENOM" id="CLU_041571_0_0_1"/>
    <dbReference type="OMA" id="CILIWAI"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39207" checksum="A717EFBDB9B60656" modified="2015-03-04" version="1">MGMNIFRIIGDLSHFASKCILIFAIHRNQSAEGVSLITQALYCAVFVSRYLDIFLWNTIWNTVLKFFYILSSVYILFLMLRVYARTREREKAWKLGALCLGASAIGAPIMMFLFQGKLRWGWRELFWTFSIILESTCILPQLLLLRQTTVPTVIDSYYLLTLGSYRAFYILNWIWRELDITDRKADAVSIIFGILQTAFYIDFAWVYYSRQRVKLRNGGIVDADDLHKGWLLRTIFGHKAVVSDEETTPAIGAGNRPSDTSRNGNKWGIRGISVSADEGLSDDEDIREFEDQDNINLSRADRFIDTGNHLKTKDTEELAQILDEDDDDGLMSDASLTNSVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6A5</accession>
    <name>A0A0B1P6A5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative vacuolar h+-atpase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002248">
        <property type="protein sequence ID" value="KHJ32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6A5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6A5"/>
    <dbReference type="HOGENOM" id="CLU_048316_0_0_1"/>
    <dbReference type="OMA" id="FSVYWAL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="35553" checksum="F8DE5C0C5E5600B8" modified="2015-03-04" version="1">MVLLTITPLIIEAIKISSEIRKNKDYIHKSQNAICVTNSTDQPSFINDGEKQSCDHEAYMIVGEQESLHIIHQPCLTIHEFSEPKVGDPISHKQLIDLSKLMKSQNHESYRLELLLQGSKIYVPPPSPKPEKTPQFKSLMARLRQDEEMRSYREMIGQKLPKDTISQRYQDTLADGAFPSNYSSPTDEIDEVMYADIRRQVTLIFNVLISILACGSAIWTVGRWWSTPTRLALSMSGSILVGLAEIFIFWGYIRRVSEAKAKEQKVKEVKEVLRTWVIQPHEDLDTINGSQESVVVNSRNTLPDTTVRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B5</accession>
    <name>A0A0B1P6B5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002239">
        <property type="protein sequence ID" value="KHJ32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B5"/>
    <dbReference type="HOGENOM" id="CLU_2544300_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="83" mass="9296" checksum="03273FAB1EF47D31" modified="2015-03-04" version="1">MPDSSEIVKVLAELEHGEKTAQMLESKLTSLETKLDNILASCQQQTSALTDELNNTVQQAGRVEKEKNSGLKDLKEKNKRYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P7</accession>
    <name>A0A0B1P6P7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001137">
        <property type="protein sequence ID" value="KHJ33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6P7"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="25830" checksum="87629046EAC97387" modified="2015-03-04" version="1">MAVTIPKFPSITALIIVDMQEDFCSYNGSLAIPNASEIIRIINKILDLPFAIKVASKDWHPTSHISFACNHVGKVPYTDTVNTKNIPKAEEKKIRLWPKHCVAGTLGAEFISELQASKIDMVIEKGTEENVEMYSVFYDVWGKDSGLSMILRELKVTDVWIVGVAFDYCVKETAIHSIQEGFNTVVLREATMATSPENWSLAEEELKNSGVKVLSIDDDDVHRVLAGSHLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Y2</accession>
    <name>A0A0B1P6Y2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001885">
        <property type="protein sequence ID" value="KHJ32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Y2"/>
    <dbReference type="HOGENOM" id="CLU_105984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="25279" checksum="5A44DE0E555A7631" modified="2015-03-04" version="1">MANDQNKVILGTGVSFHLWKSCLQAKLARRNVLGHVFHDIPGIRPLLAPYAKIAPDLDTGTNVKSPDEELAALEQWILGEIEAKNIITMRLSPSICPRNYDNMTAKQLYDTIASTRQQTAAAHYATALEALMSVTFNSTADEYIDQFLASYQSVNNAADAFSTPTAKVSEYHIGAGHAAALFVAGTKRVEWLNTWRDTRVFDSSNKYLPLEVLMSSLRSISGIFFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7H9</accession>
    <name>A0A0B1P7H9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001937">
        <property type="protein sequence ID" value="KHJ32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7H9"/>
    <dbReference type="HOGENOM" id="CLU_113435_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="14077" checksum="A40CF83505358058" modified="2015-03-04" version="1">MSESGSSLKRAHSPISDHERNGNTSTVSPDEFLVISAVEFELLVELKDQDMRDLNQLQENKERLNKVWIADVEQNMPEEKCSQYYDILRSAEFHYQKIYSKLDDVTQKISKLRTLGLSAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7I1</accession>
    <name>A0A0B1P7I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nudix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000989">
        <property type="protein sequence ID" value="KHJ34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7I1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7I1"/>
    <dbReference type="HOGENOM" id="CLU_067850_0_0_1"/>
    <dbReference type="OMA" id="DGFPNLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21576" checksum="9DE9B3B05D2EAE1D" modified="2015-03-04" version="1">MENVSTQYTSKPSFHCKFPSSLDKFRKTVEEYLLENHINGQYAGICTGAFTLDNMGRILVVQRADTDSWPGRWEIPGGACEANNESVLDGMVREMWEETGMVVTSVVGVLNDQGKSFTTRSRKRFLKFEFKVEIELPNKIKLNPAEHKAFMWITEEEFNSGKKEDADTVIDFTSEMQVASIREAFQLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7U0</accession>
    <name>A0A0B1P7U0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001850">
        <property type="protein sequence ID" value="KHJ32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7U0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7U0"/>
    <dbReference type="HOGENOM" id="CLU_055871_1_0_1"/>
    <dbReference type="OMA" id="NARIDQY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44243" checksum="A821CF3950BD0F08" modified="2015-03-04" version="1">MQNRANRKFDQYLAEGYDDEQEDDKDKDINEVTIEALTNNLESYQVGEEENTMLHTFFGETDGKDLYHTMTDFSVHHMIFSRSITKNHGTIETLTSSISRYDDRHYNGIMIDTGAACKSTAEYKQFLAYRRLCAELDPRIDTSKGKSTNIKFGIGNTTPIGTLGVFTAFGFVEFFVVKADTPFLLSLQDMDRLGVYINNIENGLIQGTKAYPVIRRWGHPFLLEKGLETSDPTFFTFDCFLTSQEIRQLHRRFGHPSANRLLKVLEKSGHNVSRNLVEKLTKFCTTCQKHGRSPRRFKFTLRDDTLSFNHTLYIDIMYINSSSYQPQSSPVLHVVDEATGFQAGRWLSNMSSQTVWNALRHCWIDTYSGPPDVLTHYQSEQSVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y4</accession>
    <name>A0A0B1P7Y4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cbs domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y4"/>
    <dbReference type="HOGENOM" id="CLU_338367_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="51"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="841" mass="95322" checksum="5517A74317E1EEED" modified="2015-03-04" version="1">MGILWKLNSTIKREEFLVKAKDLAETTARLSSEGIENSITTQHRYRIGLCILAITLLVIAGLSTGLILAICGLDQIWLHMKNITATPKERERIRVITHMKSHGTWMLCSLVICSVACSEYFPFVVQSLFLGPPWVAILISTICITIFVELVPQFFIPAYPLTWGYYCRPMIWSCMWLTAIVSWPVSLFLSHISLITNDRSVFSNDELKTFIKYHEKSEKNGGRLGREASRIMIGALNLDNCVIGKLSFGRQGNKLFDDNEAEKATQSKQKGIIKSWPFVKTINIDDIVNNDFMEKISHWSYNRLPVIGTSRRHQYSPRNNSEYHLEDIQIYGSLHLKSLLKCINKTNSSSLSVRDLPLDPLPIVRVNMSVYALLNMFENGISRMAIVIPTKKQENLALLKSMPPKISICSHLSSTDCLYTQALNFETQQHSKKCPQTRIFGNQLAEAATNSNNLEIFHSSIQGTRIIEPIGLVALDDLISAVFQRTSNERGVMYEPCSNNYSTENEPKDVIHDGYNVINNVLTSSKNDFLSQSRCSLKYHEIAAIDATDEFNFNQYPQRDLDYQSLRNNPGNSSNFQVSDMVIDRKRNSASTGYISKTKNITSLHNLHFPRSDGNPVTKSENKTFPRRKNTCTSIECPIHRNSASLITSVLPKIPRISSCSHQNVSESNLKMSYNYMNHLPSKPGPLNALKSFSSPELLIDHFDPNFHECSSKLEEKIGENKTHKYTSSGHHLHKIVDNSTPKSFSMSPKKENSYGKACANPLDLDSTCNFFKEDSEAKNKENLNFRYTSHTLPQLERTNFSLTSNRKKSSYDDSSLLPSQRRIAFKSADNFLNNYRCDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P891</accession>
    <name>A0A0B1P891_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative annexin anxc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001594">
        <property type="protein sequence ID" value="KHJ33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P891"/>
    <dbReference type="STRING" id="52586.A0A0B1P891"/>
    <dbReference type="HOGENOM" id="CLU_012466_1_0_1"/>
    <dbReference type="OMA" id="WDRPHFE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="678" mass="77896" checksum="163681CFAD5D1D57" modified="2015-03-04" version="1">MLLRPSKHETRTTRSKSPSEKSRGRSLSPERRLKRLSLRIRPEERQVEQRPERKQEVYGTRVPLISDSRHSRLPSNTHFERPLDAQSAIFWNDDENLDCREKYRYSIAADSHNLPEVSEHDLLGSVYRRSSVDEVPEKEAGASFKIGVRGHNISGGIHLSKNKLAKRISKNESSKSLKSKKVKDDPLAYGSFNSNHLAYPDPPSRRSYADVPRQETFRNRPTSVIYDSLPPIAIKPDPMLSSQRYDTTSSPLDLSLNMQSLQVIDPHHIGNGAESSLSNAQGSPLLESYRGTYQSISPMPSPLLKAMHHTSLSNFDTNYYYSSADERSSCSNGRDFRRTARFHDTEEEAKLLAKGLRGERKPPDMAPLISILPGLTHTEILDLRSQYKKIVRTTGKDKKGVNLAKHIKLRLKDQPDLMKACYTCALGQWESEAYWANYWYQNQKSRRELLIESLIGRTNEEIKLIKDGFRDKKYHNSLTLCLKTELREDKFKKAIMLVLEEKQMEESPDGSVDKDLIASDVIELRNAVKQKRGGETAVMKIILLRSKTHLRELLKAYNLMYERNFAKEILKKSENLVGELLAHILNGVINAPYRDALLLHHALSLPRIDNLWCDLLISRLVRYHWDRPHFEKIRSEFRHLYNTELQTAVAESVPRELGLFLEALCVRRTEGDVRIIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8B2</accession>
    <name>A0A0B1P8B2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001347">
        <property type="protein sequence ID" value="KHJ33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8B2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8B2"/>
    <dbReference type="HOGENOM" id="CLU_008020_1_1_1"/>
    <dbReference type="OMA" id="SLWTSYW"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079826" evidence="1">
        <location>
            <begin position="29"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="119"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="356"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="714" mass="79812" checksum="750ED11377BFF8BB" modified="2015-03-04" version="1">MSHLLNQMNLWKLVWIFSSALLQWQSTASKFSPARPPAIPLAVRSPYMNTWLNVGANGGNLSGSWPYFWTGSPAGATRGTNNAVTAWTGLIKVDNVVFTWMGSPGGTNVQQESFEYTSTRSTFIMNMDGKVCMNVTFLSPINPSDYKRQSIIGTYLEVTVSSIDGAEHSVQLYADISAEWVNPMNNKTSVKWSYEMENGVASHKVYQQNQSESNADYADDGAHWGYWYWSTIASESMSYQSGTDDVVRGNFRNYGSLPNTEDYVFRAINSNWPVFAFANNLGSVGKTSITTLYTIVHAQQNGVYFNGRDKSAGVPSFWTSYFESEIKMVDFFIKDRSTETGSLDHKISTDSIAVGGTDYQIITTLSARQAFASMVLLGTPENPYLFLKEISSDGNCQTVDVIFPAIPIFLYLNPELVKLLLEPLYEHQEAGKYPNTYAIHDLGAHYPQFIGHPKGDDEGMPLEECGNMIIMTLSYAQRMNDTKYLMDHYPILKQWVGYLIDEALIPADQLSTDDFQGTLANQTNLALKGIIAIEAMSAISDLTGHENDRQNFTNIAHDYISKWEELAVVNSDIPHTNLAYGNDSSYGLLYNLYGDRLLGLNLVPQRVYDMQSKFYPTIAQTYGIQLDTRNLATKSDWQMWVAAISSFSTQRMFISKLANWVNNTVTNTAFTDMYNVNTGDYWLGPFIARPVVGGHFALLALDSVPTAANYVKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C8</accession>
    <name>A0A0B1P8C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nadh:ubiquinone oxidoreductase subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001337">
        <property type="protein sequence ID" value="KHJ33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8C8"/>
    <dbReference type="HOGENOM" id="CLU_100674_0_1_1"/>
    <dbReference type="OMA" id="GEPCHED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="18334" checksum="20D7554C53AF7F63" modified="2015-03-04" version="1">MLYRRLFMLHAQPLRLTTQVAKMQLRCAGSTAMESAEPDYPTLTDIEDPGMNGGYVNPPRMKRQFRDPHADWWDKQERRNFGEPIHEDNDILGMFSPHEYTHVKPKTAFFQIGLFISAVFSLAGVVKIYYPDKPSVSKMYEGGLQRELGGPDAIGARALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8I2</accession>
    <name>A0A0B1P8I2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 3-ketosteroid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8I2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8I2"/>
    <dbReference type="HOGENOM" id="CLU_029944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="59305" checksum="61BBAD1DDF45EA12" modified="2015-03-04" version="1">MTTEFDGFPFVETSDDQLIVLVTGARGYLGQGISTRIIDEFLIQTKSSPQKKLILIICTRSSFQSQICVSRLYDHLQNYVKSSSFADVKRAEAEAQGSEFTWQQIMQRVLFLGVEADLCDIKSVYALADKLVNGFVESYNFPDKNENKISLKTSSLLMDVNHTSPNRTEKIFSRESCKSLHPLPRIDVILFTAGIGGWTGVRFDSLIKQFFSSPIEAMTRPRYNISRVGALLKPQSAYNAIGGSEKTTWPYSKSEENLDEPPLGEVFCSNLFGQYLLAHELMPLLSQPPTSDAQHGGKIIWVSSIATHGDSFSVDDFQGLQSTAPYESSKRLMDLLILPCEAPSVSIRAAHFFDISSTFSGRKRKNQTNFDQSNLRPVRPKNYVAHPGIFQSNILPVPFIVALICKLIFYITRWLGSPWHTINPYSAAIAPVKIALVDCKTLDEVGSSRIKWGSATDSAGNAKIRKTEVPGWGFDGKTVNEEMNTESQKGADTVSKDSIENFELLSAECWKQMEELREEWEKILKLDSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K8</accession>
    <name>A0A0B1P8K8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative intermediate filament protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001292">
        <property type="protein sequence ID" value="KHJ33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8K8"/>
    <dbReference type="HOGENOM" id="CLU_002131_1_0_1"/>
    <dbReference type="OMA" id="AMYVVEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="414"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="868"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1223" mass="139989" checksum="9602D093220BD1BE" modified="2015-03-04" version="1">MAPKRRNVIFAGIVTFFIWSWAVKWIPLLRWVSYAFVIGLVLPVLGLITLLLSTSRRITRREKQSIRRPKGVEFLAPALWKIEVAALQARQQYEKQSLYKESQAISDALNEILDLIARDFVNSWYSGISKSPVFTNEVDKAIRVVLVNLRGRLFVLDLAAILIARIVPILTAHFRGYYNAEREVRGKYLNRTVTESEELDLAIAARYNNGKIHPAVCLSYSDTRLLQQEYLRNVVKDLLPRLLPESYLASRTASALVNELVVCTILIPTIQLLSDPDTWNQIMESYGRSMLQDRSTVKKLRFALDQHASPVPRITRGILFPRLAPGDDEKRFEKFLRAIRKLNNVSDARRFRSEISSQLKKEAAQVKDPVHLRRLEIGKRLLDQRVDHLAVGRKRSYDIHETPKNATSRLENSSLVDILHDTSGLTYFMEYMDRQKLLTLVQFWIVVDGFRTPLESDFADDDINTASLSYTELDRKDLAQIYDCYFSKLELKISDTSRRIVREFLKAGKDASPRQYYLARKEILKAQTATLDVMQENYFLNFKKSDLFYKCLTSQEAMNSQTHENSELLVQENYITSRVSSSPILPTKDSTISRVSNRISSKNEQLQLHINSSLDLTNSIAKPNYNWYTRSKTNGNNPIITDDDYIETEGMGDSIGSLDQVSNRDLPDNKVVQAMEAALNMIMEDKPNVEDLRNSLFDEEGCPSPFRQSQNTSSPSSSVHRKRANKFAEKFERIEKPNISSLGLVNMSSRIGVFKDDDLFPDEEKFMSDEHEDPEEDESDKDDEVHEAAPGDLGLAEAIMALTIDIERLEAQDDVIDSMTRKAELTNNTAELRILKKSKTSLQREIRRKELQRRQYVVQESDNSLFGRSNIKIKSVQIGREDDGREFAVYVIEINRKAGEQIPAATWTIARRYSEFLELHQRLREKYTSIRNSNFPRRRMVMKLQTEFLQKRRQALEKYLREILLLPEVCRSIELRSFLSESVTSPGGDSFHDNDENKKDLVTRLYNSITDGMEEIFGSIPVFDQISVAGQNLISSATQQLISIPSTGIEDPLSAAEAEAELNAFENKELEPFIKPICDIFLEIFELNHGNNWLRGRAVVVVLHQLLGGTIERKVRENIKGLFSEDSIVRYIALLRDSIWPDGELKTEKKPRTSAQKVKSKTEASFMLATLIPDLAASVVGRVNAQAASRRIFATLNNPRLNVHLIFTILDEILDIIFNDRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L4</accession>
    <name>A0A0B1P8L4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001292">
        <property type="protein sequence ID" value="KHJ33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L4"/>
    <dbReference type="HOGENOM" id="CLU_2335193_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="98" mass="10947" checksum="8FBB870716DC5520" modified="2015-03-04" version="1">MEYSLKTSFSLPEMTEHKMAKNKKDKTVVKSEGGADLTDAVKSRLELMNPYLQNIEKDHQDCLVQCAVKELTLAHAAHAAHAAQIAQRIIMPSPSEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L8</accession>
    <name>A0A0B1P8L8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hpt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L8"/>
    <dbReference type="HOGENOM" id="CLU_085158_1_0_1"/>
    <dbReference type="OMA" id="AENDFND"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000007">
        <property type="entry name" value="Multistep phosphorelay regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="23765" checksum="F7971489499E69CC" modified="2015-03-04" version="1">MSDSHNPRESEAENVENAEGSTGLYDWGDNVDTSTFEQILEMDDDEEEREFSRSIVIGFFEQAETTFTQIEAALESKDLPKLSSLGHFLKGSSATLGLTKVKNSCEKIQHFGQKKDQEGIADEDDEDKCLKRIEETFQTLKKDYVEAVNILKTFFGINSQDGSTTEDEQIPKTVTSLISTVTKEEDEKEKEATTILTPVVTSTITSTIVSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Q8</accession>
    <name>A0A0B1P8Q8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001650">
        <property type="protein sequence ID" value="KHJ33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Q8"/>
    <dbReference type="HOGENOM" id="CLU_1267735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="23974" checksum="7FA7E773A9506752" modified="2015-03-04" version="1">MQIKTSTFVDSLCKDSNKIAPNGKGLVMEEMDFEAIEAEIIERIRVILEIEIVNIEVDKIMTKGLNESRWARPIQNKDSENSSLVSRNLQSKAAARGAGQFKGLSKLIQQPNSILSALRTRLSIGEISQQTACKNTEIENARLKEAVGEMSLPQELQEMIEVEIRRAAQAKSKIKIYATAINVAGDSLSPMLTAGNNSFTDSPYFSRGFNSAILASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8V3</accession>
    <name>A0A0B1P8V3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative peroxisomal abc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8V3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8V3"/>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="373"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="658" mass="74407" checksum="C5D22A4644AB48BD" modified="2015-03-04" version="1">MIPRWTSKETGLLLSHGVFLMLRTYLSLVVARLDGEIVRDLVAGNGRSFIWGIFKWCGIGSFASYTNAMIKFLQSKVSISFRTRLTRYIHDLYLNDNLNYYRLVNIDGGVGQGVDQFITQDLTHFCASAANLYSSIGKPFVDLIVFNYQLYCSLGPLGLTGLMSNYILTAILLRKMSPPFGKLKAVEVRKEGDFRFLHARLIANAEEVAFYGGASMENYFLQREFKSLKNWMEGIYALKIQYNILEDFILKYSWSAYGYLLSSLPIFFPAWAGLGGVQELAEISVNGALEKSRMKDFITNKRLMLSLADAGGRMMYSIKDISELAGYTSRVYSLISTLHRVHADTYFPPRGIQPELFSLSDVQGTIQKGFDGMRLERVPVVAPSIYPLGGEQLIESLSLVIHSGDHLLISGPNGVGKSAVARIVAGLWPVYRGLVSRSRNIGTDGIFFLPQRPYLSAGTLRDQVIYPHGAVDMNERGWRDAELQRVLDEAYLGYLPEREGGWDIRKEWKDVLSGGEKQRMSIARLFYHEPRYAFIDEGTSAVSSDVEGLLYEKCKEKGITLITISTRASLKKYHRYNLSLGMGDDGNEWEFEKIGTEKEKLEVERELKELTECLDKVPDWLNRKIEIEKELSKVWIEGGVELEESTYTSGQNLEDNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Z8</accession>
    <name>A0A0B1P8Z8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosome recycling factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001239">
        <property type="protein sequence ID" value="KHJ33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Z8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Z8"/>
    <dbReference type="HOGENOM" id="CLU_057161_1_0_1"/>
    <dbReference type="OMA" id="NVICGEE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="4">
        <location>
            <begin position="103"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="276" mass="31121" checksum="E4F9C541E707D531" modified="2015-03-04" version="1">MSHLYLRRIYNVSKPFVSLFQATFNKEKTNASLYFLKSTNNFSNSPILFKKKGKNSSIKDERDEVGEKKFSKSKIATNNINNDDDLWNFTNLKEGIKERIDWLQSELSKLRKGGGFNPDLLENLRIVVQKGSKKTESLGDLAQIIPKGGRSLAIHVGEKAHVKPIISAIQSAAFLNIQPTQDPEEPALLNVLIPPPTKESRDLALKMVHKVGETATTGVRSVRAITQKRLRNIELKKLARPDDLKKAHKEMEIIVEKGIVDIKKCVELARKAIEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P901</accession>
    <name>A0A0B1P901_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P901"/>
    <dbReference type="STRING" id="52586.A0A0B1P901"/>
    <dbReference type="HOGENOM" id="CLU_019271_0_0_1"/>
    <dbReference type="OMA" id="CEYVANG"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="41326" checksum="92DF581BB78DF11E" modified="2015-03-04" version="1">MQEKNEDDSFEALCKEDKKLIRWRGLQLIGEGTFSRVILATSAISDEVSFNGRHLVNQHLKPLPHKPFSERKKSDKLVAVKICEYVANGCESGNFMEISAKREIEILKDINHPSIVHLKAWSIEETRTILILDYCPGGDLFKVASEHHDILVPDLVRRIFAELVAAVQYLHARKIVHRDIKLENILVNLSYHDLERQQDWSKYPFSVVTLSDFGLSQRIDDDEKLTISCGSDDYAAPEVIMGQPYDGRVTDAWSLGVLLYALLESRLPFDPAPHTSKNSRPCSRTSHLIARVEWRWFKYADPTAQLQNDPKDSCRHALEGAILITEGLLRRARDRWSLDQIARTEWVKNAIQIDGGIKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P957</accession>
    <name>A0A0B1P957_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pxa domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001185">
        <property type="protein sequence ID" value="KHJ33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P957"/>
    <dbReference type="STRING" id="52586.A0A0B1P957"/>
    <dbReference type="HOGENOM" id="CLU_018250_1_0_1"/>
    <dbReference type="OMA" id="KEFVYSW"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="86"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="557" mass="63596" checksum="4678F76D6C3DD76D" modified="2015-03-04" version="1">MSHHLSRSRIRSSVILHNSSRNTSIDSRSNKTQSPILDPGLHITTESLSDRATLSFVRRILCSQLGDKGRSTCTSIDEILPPLTSSNEVDLQLYAFIAIIIREFIQTWYQKITSDQIFVEELVNIFAHCTRALEQRLRKVDLESLLFDEIPELLEIHINAFHLSHLSLHQPPLEHDPRQIYHLLWPIPSLSPVPINDLQNVVSKQEQTKNESFYRHLLVQGVLALLLPTEDLENDCLRSLVTEILSESILGEVIGEKVSEPWILWEGITKLALVAKSQISQYKTKTPMNQSVSTTSSTVSQESIKESNLNLRISNSIQHMLWLFLQYSYLIFTAIHCFIALYTASLSQACRNKCFNIKISEEPLDHDMNSIPSHQVYKKPILDMKLWSCLAKLLNLEVRMPWLKAMLSMLQWVALTGPGNIGQTDGIIDKILSYTIQTHILTTTTLPNLLRNARAALFPNNLPAGQSEAPNEAECMAIRRRCAESILDLIPIGAREIYFGLEWDDMVRQVEEDILCIFEDKYCNKHFLYGIVELLLVRLMPELSEHSIQDLLAERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B2</accession>
    <name>A0A0B1P9B2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative glycerol proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9B2"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="CGMASCM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="514" mass="56218" checksum="DC953E2776B84257" modified="2015-03-04" version="1">MINFRLRGNALSTAHTILVAAPCFILFGYSQAGIGGLLSLPSWTSTFPAIDTTNTTGAVKSRHASLQGIVVSSFVLGALAGCIACMYMGDILGRRKSIFIGGVSIMLGQILCASSSSLAQFIVGRTFNGAAIGIFSSTVPVWQAECSPPAHRGKHVVLDGVFISMGFSIVSWVNLGSSLIKNSSSSITWRLPLALPEIFIFILMSSIFLMPESPRWLVQVNRYQEAAESLSRIKDLPIDDPSVTSALEDFRTAVQQGITKKTSLGDMFTMGPDKLFYRFCLCILLQFYQQMGGSNLISIYAPVIFEQNLGIHGRTARILSGATLTWKFLSSFVAFFTIDRFGRRPLFMFSGVGMGSCMLVLAITTGCDMNNLVASYISVAAIFLYNFFVPIGFLGANFLYCAEIAPVSLRVGMAAISTGNHWLWNFVISMASPVAIASIGHWYFLVFSVFGLSIPISVWLVFPETMGRSLEEIEFAFKENQTIRGVVRTSLRSYQHNRNDGEKIVDVTDEKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9E7</accession>
    <name>A0A0B1P9E7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001117">
        <property type="protein sequence ID" value="KHJ33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9E7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9E7"/>
    <dbReference type="HOGENOM" id="CLU_052998_0_0_1"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="305" mass="34426" checksum="4D59CC4A57C04F18" modified="2015-03-04" version="1">MPTLQSPKNNYSTIPLENKSDRKAQKKKQFQERLTSEDGAVQQGNNKGKMRKEVVVSKALSKLLRHAASDVGLKLDSEAYAQVDQVLEWQRLKSMHITFADIQKVVDEDAKCRFSLKPNPSRATPEPTEPSDWLIRANQGHSIKVDSEKLLIPVTNEMNNIPDTVVHGTYYCFYSSIMKSGGLSRMTRTHIHFSNGVKKDGQKVISGMRKDAEILIYIDIKASIEDGILWWLSDNGVVLTEGNEKGLIPIKYFKKVVGIDNEIGILMENGVEFKKLPESSAFKTPMGKIHKVKVHDKSQFKKVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Q2</accession>
    <name>A0A0B1P9Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative fungal specific transcription factor domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001480">
        <property type="protein sequence ID" value="KHJ33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Q2"/>
    <dbReference type="HOGENOM" id="CLU_355674_0_0_1"/>
    <dbReference type="OMA" id="FRYVNHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="773" mass="90567" checksum="58D07E0721934139" modified="2015-03-04" version="1">MKVVSTKILLYQTTFHQAIQRRSPIQNALPSDEIIPEINYFLITLPKIYKRYGSFVPGPMESRRRLGKRRMAYNFEMIQNDTVVSWSWWRYFREHDFTDWKWKPPRSISITQEFKSDTSQYSPTDWLLSIFNVYKSNNTSKCYELEISDDILLYQELSNLRAAIDGGSKEIIFDVCQNLNNTLIRCLRNGILCGKEIEFVIDEASQQFRKNILEADFKNSLCYSFYRTVWEELRTIEPKNSAYFISQLTITILKWLSKLHLNLKGQALVASIIQTLPENVIKKVPYENFRNILISWVLSWGDDLNQVDPLECLHRHSEKNHKNYISMAEEIISNIKLELSNIDTLISQHKSVYQIKILLCQSKLNILSGLRAIESAENFLTPNNISASNLAKVLTSLPPKIMKTLITDCSKNLCDLFQQNRTIESHNIKKYWLTTISQISTLYNEEFLSMWRFLDKQSESLTKFSYPELFINRWENQCTPEEQAHIRNNMQITNIFPDEEFGPWISLIKVIYKCYPLESHFINIGAVFGMLYGFGKVETLGNIILHMSEIGPRLSAEILEFALEKVIAFNPKMAWKIAMLSPTMKPGRKYRSERFPNGDYRTLRYCYCPDFILWMIRDSKINPKFIWKLLRIPIHLKYSPRYRNQPSNQPLHPKTEALIKVMAVAFANAERLSPRVAFRNVMQCWHHLCHHKTPIDNTIVNALIHSGITRYMESGVWVPESRKNWLFYLLEQVEDSGAVNQANQIVTAWNKKITLSKLWHQRESNVLRVGQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U4</accession>
    <name>A0A0B1P9U4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative cation chloride cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000570">
        <property type="protein sequence ID" value="KHJ35023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P9U4"/>
    <dbReference type="HOGENOM" id="CLU_001883_4_0_1"/>
    <dbReference type="OMA" id="NDLPCRA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="129"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="617"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146421" checksum="A1A56EF8617177AF" modified="2015-03-04" version="1">MKSFPSNTSCFDLNRSHQGEASAIQDEQRQPLLTSEQLINRSDGIETPHGTSNRCSAVSNSGQEDNIKSHRGKYGSQSENKTLMKKCISEYGTMKIEKIYERIKKKSSATVPTEKLRPKEIKLGMFSGVFVPTCLNVLSILMFLRFGFLIGQAGFLGIMGMLIASYLINLVTTFSLSAIASNGTVRGGGAYYLISRSLGPEFGGSIGLIFYLGLVFNTGLNAVGLIDCIKLNFGKTSGNWAQILPESPWYLYLWSTVVLLVCTAVCFAGSSLFSRASNALLVILIIATLSIPFSAFLISPYQEKDLGIDYTGLSWSTFLSNLKPHLTKGAAGSQLQGRETFQDLFGILFPATGGIFAGASMSGDLKNPSKSIPKGTLYGLGTTFVLYTIVIITMASTVTRETFIRDANIIQDTNISGLVVLAGELASALFSTLMGVIGSAKLLQALARDNILPGFSIFSQGTINGDEPSNAIIITYVIAQITMLCNLNQIASFITMTYLMTFLVMNLACFLLKIGSAPNFRPSFHFFNWQTALFGTIISAVAMFFVDGFYATGCVSILILVFIIIHYNTPPKSWGDVSQSLIYHQVRKYLLRLKQEHVKFWRPQILLFVNDPRRQYKLIQFCNSMKKGSLYILGHIIVSDDFGSSVPEARRQQAAWSNYIDFSKIKAFVNIAISNGIEWGARNIVLSAGLGGMRPNIAVLGFYNFDDLKSEITSAENLQPRKHSLKSSPNSKPLLRKGKKSRKSSKDTNLDGALPTDSCKTEGMISVTSYVTVLEDLLLRLQINVAVAKGFRNLEFPSSQDNSKKYIDLWPIQMSAEIATGGVDKQNVLTTNFDTYTLILQLGAILNTVPAWKKSYKLRVLVFVEYESDVEEERGRVESLLENLRIKADVLVFWLASGDYNSYEIIVNGKNVSLQAEKEVDECLNGQDWWDELQRIRGKRGPSPAAEKISQLVEIFKMGPTWPDSSFQQGPRRKMFKRFGALRKLLKKTKRKQIINGTNLVMHTHKLAEDLVKNYSDYTSASEDSAMSLDEESDGESSQSAASENDAKDLDSENEDIELGTSKLRRWKSCNDTAQSMAHERRTTIQKDPMDQPLNSNALGEVDQHPDCVSKIGERKGLGISQLSSLEMKPELRKDLKNCYHNNISQIMVKSRQMSLVSSHQLTQNISRHASQPKFSSKPVPVSHVATEDGPGPSIMFTPMSPPSRDGSRLPVDHSATSSVLTNTPNLSSRPNLLHEGSSYSTQNLPLSFNDLPRSAQHLILNELIRLNSTETVVMFTTLPSPVEGTCLSNEASASYLKDLETFCRNCPPVMMVHSNSMTVTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Y0</accession>
    <name>A0A0B1P9Y0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g3120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="JNVN01001025">
        <property type="protein sequence ID" value="KHJ34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Y0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Y0"/>
    <dbReference type="HOGENOM" id="CLU_019582_2_2_1"/>
    <dbReference type="OMA" id="ECRDKNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="512" mass="57730" checksum="D389B5061C15ACB0" modified="2015-03-04" version="1">MVHLTLIPNVQTKDEALAQGAEKPTINGLDTTSTIVYSSRFAVEDLPTYEIAENEIPKETAYRLVKDDLSLDGKPALNLASFVNTFMEKEAEDLMTEAFSKNFIDFEEYPQTVELQNRCVSMIGRLFNVPTSNSIAPVGTSTVGSSEAIMLAVLAMKKRWQKSRISAGKPYDKPNIVMSSAVQVCWEKAARYFEIEEKYVFCTQDRYVIDPGEAVNLVDENTIGICVILGTTYTGEHEDAKAVNDLLIEKNIDTVIHIDAASGGFVAPFVVPELEWDFRLEKVVSINVSGHKYGLVYPGVGWIIWRGTEFLPKELIFNINYLGADQASFTLNFSKGASQIIGQYYQLIRLGKSGYRAIMFNLTQIANYLSECLKQLGFIILSQNTVKSLPLVAFRLNPASKRHYDEFSLARQLRSRGWILPAYTMAPHSEKLKMLRIVLREDFSKSRCEQLLQDIKLCLKFMDSLNEEDALKSQDYIHKQSIHSGNVKHSHSEYKDERHSLKGKTGKTHAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA83</accession>
    <name>A0A0B1PA83_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000982">
        <property type="protein sequence ID" value="KHJ34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA83"/>
    <dbReference type="HOGENOM" id="CLU_1612036_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="165" mass="18257" checksum="5831A2BD6F00C722" modified="2015-03-04" version="1">MTSDKAKCCEQESSEVDGFVKTAYSVLVASAASLASSVLSTTSSHEMLGNIMDSLVPLNKAQLSSSSPTSNSPLNESKVGIFPKPSQSRYFHSLLPGHNEHYGDETKQEYYRILSDNSFEHSQFSYSKKNPKIHTRHQVMQKQMNQLAPVLKNGSAVMEKQLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAH4</accession>
    <name>A0A0B1PAH4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAH4"/>
    <dbReference type="HOGENOM" id="CLU_2724099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="72" mass="8154" checksum="03D866748CB01233" modified="2015-03-04" version="1">MILVKELRFLQLSLDPEYRSDKHLRLKLINVCRNIKACQLACFKPSDTLSGLINDLQSSISTAEENSNESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB45</accession>
    <name>A0A0B1PB45_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000379">
        <property type="protein sequence ID" value="KHJ35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB45"/>
    <dbReference type="HOGENOM" id="CLU_1929153_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="131" mass="15087" checksum="D3F5050F31568158" modified="2015-03-04" version="1">MLRLPLSFRMSSISPYVSSASHMPFYNHCDQFRYSTQAPKGPDYPTPKSSHVEFYKIFGRPIAKVLLMSACTYQLAFLLWVNEETKEKKAEKAGKSLKSFRRKGLQLKVTNNEEIMATDNSFGINNYRTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB97</accession>
    <name>A0A0B1PB97_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000788">
        <property type="protein sequence ID" value="KHJ34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB97"/>
    <dbReference type="HOGENOM" id="CLU_038508_2_0_1"/>
    <dbReference type="OMA" id="HEAGCAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="351" mass="38055" checksum="7CAB85C355ED826F" modified="2015-03-04" version="1">MATDPNPVPFSPLHQKTIEKGSTISVSQSTPRKSQVQITPRALSPGFTNILPSNQAAVSGITATGNPVRIADSSTTSLEKTAAIDAGPGPLRLPKPLTAVDLYAQLEKEQEAVVNRLTRELSLLRAAQNTSVVSSVSSTSASGFQDNGEYNFSSFLSGNSHPTSSYISRNRSSSTVSSHSMTAINPTSFMSCMAADRAVGRSGITRRESNPGINHVNIGGNSTSRRNSTSKFNLQGHYQSGASSPIAVPMNPSNYNHYHSSEQWPSINSSYSSRSALQRDYTSRSQCMTGSVGEKEVHLHNRFEDVAMHRLELENAKKENEILRLRVRELETLLIQKKQAAEVVPAKPLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB0</accession>
    <name>A0A0B1PBB0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcription initiation factor subunit taf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001136">
        <property type="protein sequence ID" value="KHJ33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB0"/>
    <dbReference type="HOGENOM" id="CLU_000572_1_1_1"/>
    <dbReference type="OMA" id="RFINYYR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="417"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123079" checksum="11F213D56E0A8BEC" modified="2015-03-04" version="1">MKNDRNASSIGATYTMSETLSFNEIDWQQAEEDDNNAIEQLLKGAGEGEPILNDDRELDLGEKADDAEDFEDIGDDDLPDEEEPSIKKEPFEPSMEDIDIDEDDLFGDGGRASSPFEDNFDAKHIEIMNVPEESEDVKPDIVFPTLEPDPEIDLRELNFPSNFDTGEDEVIPDDAEQVRKLVQENFPSFDTEGILFWNELLATKSAYWTPQVPIKPPKPITPTKISLDLAVDQEKPFRGSTLLAADKLRRSTEPLMKGIITIKNESSELEESEDEFDYSYPDPSDKVAGYTLREFDFICADFESAINAVCPPDNEENEAELMDEWEREILGHPSNLKKKASVEKDFTIEPSYLVPSFDNFEEITAQVAKRVVIDLNDPYLLLDFQDFDSQAKRQRLSSGNYLRAGNNSYTSSLVSRFNFSNDEAYDALKENHQSKVRATLGHLTVEHSMPALKLQWPYYQVKLYVDQARSFHRPSLKFKRFLGQVIYFSKPGMRKKKAIKGMQTHEIFKETKDLSLADHYSTATLFEYSEEHPTVLSGFGMGNRIINYYRRKNADDAERPQPEDKIGDTTVLLPEDRSPFSNFGMVDPGQTVRTLHNSMFRAPIFKHEPKSTDFICIRSSTGVEGTKWHLRNIDNIFVVGQQLPSMEIPGPHSRKVTNAAKNRMKMIAYRKIRHSAQRNVKIADVTAHITDSTDMQNRQKLKEFMVYDKVEKVWKMPPGDAVRDEAQIRSMIKPEDVCVLDAMQVGSRYLEDAGYEAKDDKDGKDMDILDGDTEESLEQSLAPWSITKSFLDASADKAMLALKGPGDPSGCGLALSFLKTSMKGGFLQNLGKDKGDLNHKAKEALDPSKNGGHTYNVKLQQNIYNNTIREIWDAQMASLSDKCEHYLSQEELDKIDTPRGTHFDDTASQYTSLSTSEKIMRITRRYKNKLGEIEEATEIVTDARVWKAYQKRRIEIDTAGKDVTSFRPTGDPEKDEAQKRAIRKELARLNKNRVRRHVREKQKGRINTPQATSPGPSGSPISSLTPSIETTTGTSRKCANCGQAGHIKTNKKLCPMLNGTVRSNDSNPKDGGFGSISAPSFSSTGYKFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG3</accession>
    <name>A0A0B1PBG3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001109">
        <property type="protein sequence ID" value="KHJ33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBG3"/>
    <dbReference type="SMR" id="A0A0B1PBG3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBG3"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
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    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
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    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
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        <property type="term" value="P:mitochondrial DNA repair"/>
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        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
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    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="349" mass="37680" checksum="47C70F795BBA1013" modified="2015-03-04" version="1">MADDDQETQSVVEEMGEGGPGAPTPLSALEGVAGLTKRDIQLIIDGGFNTVESVAYTPRRILEQIKGISEQKATKILTEASKLVPMGFTTATEMHQRRSELISITTGSKQLDTLLAGGIETGSVTEIFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLAVANRYGLSGEEVLDNVAYARAYNSDHQLQLLNQAAAMMCETRFSLLVVDSATSLYRTDFVGRGELSSRQTHLAKFLRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRLSLKKGRGETRICKIYDSPCLPESDCLFAINEDGIGDPSPKDLEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBI8</accession>
    <name>A0A0B1PBI8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000969">
        <property type="protein sequence ID" value="KHJ34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBI8"/>
    <dbReference type="HOGENOM" id="CLU_000288_29_2_1"/>
    <dbReference type="OMA" id="FIAHERA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="975"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="568"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="677"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1268"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="677"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1274"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1290"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1337"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1004"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1425" mass="158047" checksum="73C7C83089A02EB6" modified="2015-03-04" version="1">MIRDQKPNVVSCRDLPLSKTKENRKPSVLKNLAAYDLETNNPTTKDHTLVSINSFGKYSVDSDESVSADFLPSPSFDDLQNRIFSASRNLQMIRFEDSFTSTQHNSTSIYNPAGPTEGKISDVQYSNSGRQSSASGLLSARSIIRQQSLSTQSNLSSTSSISSETMDSPNLSATTCSRRHSQYPISAGVTCGNMKKASRKPIAPLASDSESRLSSRRRPSSIIASQGQGEIHGSTTLSTQTQNSICTRGFSVSRAAKTKSFQPPSGSGKSLHIAGQFDQQNMISMADKPYNFMNEKGIAWSSSRKRISVIPGMPSPSHPTGLGARTVSPTDTRRAKRMSNLQAPSATPHTPPTPQSESSRKGVSTPLLFNTVAKVSTPSTPRISPDSNQKCYTSRLSPASTPGLHCHQESTSSLQSRVMRPVSSKLPKSKPRNLHISAENERQDGECVPPVPAIPKAFESPKDISAEHASFKKKHNLIVESHQFSNSQINGCFNDCFSQLDSQEILKGAFSQPVESTDSKSGPDDLDTDYGKKQSQPLRLPPMNLRPLSTTTVNKVEAYKDVKSSEDKFSSNFSVSSPMTASKKSPYHESKRDASKLVRSPEHSRSSSALHSLRSGSNSNIFVTSKTASMYRDTRAGFPPVSSAILSKKTGPVYGCIPRTRNSDDIITERISDQTRLSRNGPHTLNVNRNGSIGGTPTTQPCNSDEPSTPLSASSLRRKLSLGWRRSTSKSSVNFYTNNEREAKNASVLKIDDNISPTRPQPLSATMSNLGSDNLPSPSLSVKSTTYFDFKRRKSSVSSMSMFVGYHDRTISEGCWGIQNNSVTNSKLNPDHSVLAPRTSSMMYRKLNVKGPVVSTRAIEDWTVDLDKDDLTAEEEMKKLSSKRKETENAARRLNALNERAFAKEPMSPEEAIMKRNLNIFERGEIVDYQEIYFCGTKEANKYVGDFPDEEHNFGYDDDRGDYKIISGDHISYRYEIIDLLGKGSFGQVVRCIDHKTGGLVAVKIIRNKKRFHQQALVEVNILKKLREWDPNGSYNMIRFTQSFYFRQHLCISAELLDMNLYELIKLNSFRGFSLKIVRRFTKQILNSLLLLQQHKVIHCDLKPENVLLAHPLHTEIKVIDFGSSCFENEKVYTYIQSRFYRSPEVILGMTYGMPIDIWSLGCIMAELYSGVPIFPGENEQEQLACIMEVFGPPEKHLIDKSTRRKVFFDSLGKPRLALSSKGRRRRPSSKSLHQALKCDDPAFLDFISKCLKWDPDRRMKPEDAIRHEFITGRKTQPPSSSSRHISLRNTSPTKKNSTTKSSLLTRPLPEPPLTSSKNDKKIKSQEILSGKGSPIKKSSTMASYSQRRQSTIIGTTSPQYSKRIVQGANNSSGTNKNALPRAARNASSRIDAPKVGSNFFPRNSSLMGVSASNSINTAGNRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC23</accession>
    <name>A0A0B1PC23_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000990">
        <property type="protein sequence ID" value="KHJ34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC23"/>
    <dbReference type="HOGENOM" id="CLU_034574_1_0_1"/>
    <dbReference type="OMA" id="FWIFTIC"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="34278" checksum="6DA686269A1CEECF" modified="2015-03-04" version="1">MGFGRVICVLLPMALTVASVVSILTVCLAGITNKSLQLFAVTTANFSASTATLDNIAHEIFRREAQLTGIPEIIPSLENQIKNSRDIVSKISGVAGDIVDAKTKFDALTSSEGGNITAKVLGLADMYKVSIWNYCRVTGTETNCTDPSYDWAANSLNTSNIESQASEASGTKVTLPDEIKAALNSFVKISKLTQIAYMVALIFGGIEILFGFIAMLSRAGSCLTYLVSGIATITITIASVLATVQASAVTAALNSASKAYDVKSKINTGFLATTWLAVAFSIGAGVLWAMTSCCCAAGHSTGRGRSSSYVEKQRSNMNYQRMNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC31</accession>
    <name>A0A0B1PC31_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC31"/>
    <dbReference type="STRING" id="52586.A0A0B1PC31"/>
    <dbReference type="HOGENOM" id="CLU_061830_1_0_1"/>
    <dbReference type="OMA" id="WIHIWIA"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="248" mass="28806" checksum="E1B9858CB2A03E08" modified="2015-03-04" version="1">MVQKNSIWHFLSNNNRIRWPPLTQKKIFPNSRLVRNATSGVQPQVLEKPKKFNPPSHGTRLRNPSPRYYGPQLTTEELAMQKRKKYPNMMPPEGTFIHWFLHNKLIHLWLSLGTLTSLAATVMITNFKRESPFAEMLPDWYNMFLHPIRFWRTIIEIIKLDTARTSAEAAEKRKQRVDDVAKRAAFRKAMGLDQDEGLGGWTLKSSHKISSPEIQAQNKDAVPSDGNQNNLNDESLRKKPLKKWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD2</accession>
    <name>A0A0B1PCD2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl-thioesterase ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000072">
        <property type="protein sequence ID" value="KHJ36322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD2"/>
    <dbReference type="HOGENOM" id="CLU_032690_3_0_1"/>
    <dbReference type="OMA" id="QVWFRTN"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="172"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="346" mass="38854" checksum="219FD44EE0A49106" modified="2015-03-04" version="1">MAGKSTLFNPPPNDPSKSLIENLLELTDTSIIEPDLFTNTRPLWHPPGARGIYGGAIIAQCLAAAYKTVPENFDVHSLHCYFVLAGDSKFPVMYHVERVRDGRSFATRTVQARQRGICIFTTSISFVRENSGGKHTIQHALPLPKGVKKPSDDCNLNKVYTSDNNPFITYHDTNYDQQEKKIHEKKVKHWMKAKGDISEAGGHQAHLIALAYISDSHFLGTVTVIHDYFKYPSNEKKGFIRKLDNSGDPVKVHQVGVDLQNGSKEHKSPFELGMLVSLDHTIYFHEPRKFKADEWMLFDMASPWSGQGRGVVMQHIFTADGTLIATCHQEGILRLSKPKSLKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL6</accession>
    <name>A0A0B1PCL6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000026">
        <property type="protein sequence ID" value="KHJ36427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCL6"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="IDIMTER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49512" checksum="F727C3A8DE4370C2" modified="2015-03-04" version="1">MEVSESLILDLSASEKDDVFNTNRNIGVWLRDISQAYTQSTTKLNRLFYAKLPEQFKNLYPNDTIIVVLKPLYGIPEAGTHWWVTYMNHHKKELGMQSSTYDPCLLITEGDILGLVGMQTDDTLILGDNLFSELEERKLQFTAKPKQKLTRDKPLIFNGCILTLNDDFSIHMTQKNQGKKIDLVEDIDSKVYVQQRARGAYIASICQPEACYDLSVAAQTKNPSKDDLSKLNKRLQWQKNNLDRGLNNVVLNLRHAKLFIFVDASFANNEDLSSQIGYIIVIANETNQEDHKFTITSNIIHYSSTKSKRVTRSVLASEIYGMVGGVDMGYAIATTINLIFSQLDLPEIPIIVCTDSYSLYECIVKLGTTKEKRLMIDIMALRQSYERRELYEIRWINGADNPGDAMTKANPNKALETLIDTNSLDIRIEGWVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD85</accession>
    <name>A0A0B1PD85_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000109">
        <property type="protein sequence ID" value="KHJ36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD85"/>
    <dbReference type="HOGENOM" id="CLU_429060_0_0_1"/>
    <dbReference type="OMA" id="RDGSWDC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="638" mass="70825" checksum="DB0958B68FA84956" modified="2015-03-04" version="1">MKRITFASNSYLSIQLGAMTISISSPADIDYRNIIHSSPKSPVTCYSPGSCQAESAQNDDLLDDILAFLDGQNPSSQLYSSASSPRDVSTPYSIKKWVEGLPTSPNTTLTFSLPPSPLQDPTMSSISTTSSVPQSPVSLFSRLNNEKGVLTSPDLSTSSGSPHKDHNTGCINSCNLEVMDLALPIRSEPIGPLPALPERSPNRILRRQQKVDLINLPLVDKKANSMPDLKERMIGNPKSENTAVVDIKTSEASTRKTHIQRRALGVVPSLSEFNFPFSPINENTVTSESPDIVSSNHWYSRAYPNSPPQTMDLSQAKTNLTSNLLPRQYHNVEIANDQNAKFVSKSLSHIRSHSLTSANSKNFHSPKLQANYCINSSSAKSRMPLSISMTTGNLEDVQYLSPTLLGVRRIKNEDPDIYSLNLKAKKESVLSLMRKNAAPGIRLGIRLTAEKWDLLNTCRVIGMEVRLLTVRRRSLSGTRYEWHVVDNGMAVRGNTNCGRFVLKCLGELDGRVDFFTSEGIPIFRFQRTVGSTRTATSIDGDNENIYFSVRDGSWDCSVHWEVSLYKKKDQIAGKWLVSGDDQMQWLDIKQGDRTVGIIRDSGDHVYTLKVFPYNNWCIITALATFFDEWRAARVGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDP7</accession>
    <name>A0A0B1PDP7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dna mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000539">
        <property type="protein sequence ID" value="KHJ35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDP7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDP7"/>
    <dbReference type="HOGENOM" id="CLU_2293790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="101" mass="10923" checksum="4F210BF3900DF3AE" modified="2015-03-04" version="1">MQEQNAKRKIIISQVPLHGESRKVPCHYSQAYKLINGKALDPDVVNKIAAGEIIVAPVHALKELIENAVDAGSTSLEILVKEGGLKFLQITDNGHGINVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDU9</accession>
    <name>A0A0B1PDU9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000027">
        <property type="protein sequence ID" value="KHJ36423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDU9"/>
    <dbReference type="HOGENOM" id="CLU_370951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="750" mass="83760" checksum="41A85C07FF2157CB" modified="2015-03-04" version="1">MGLIFKALFSISTTGRGSKKTQGYSYDASVPSSPPIKGRHPILGNGPKSMSIKPIRPAKAQRHVERQITTSASSTTVSSTTYIPDTPRVFCKIESQSTVSTSPTNLRLEHGRRSWEKDTRWSRPTISTSFIPSTPQRPKTGNSPVSLPKKVRHLDSLPKDFNFIPRTHHVDLLDAHSLIHSSEKMTRYREKASGTRSYGEDVADRNKQPQILESPIERLDTPQEPRPLIDSPELKFLKEIHLANKRAVGMTDDESIRALSPPPQKVGNEKFLKNNLPIKLSHPHSHPIRSLLNISNEVHQSVGINAKPDRARSQSLSKPLPNTPSKDDAMLKVGASLFKTPGNPVSSAARDCTPPKISKGYSTSVPKEIPDIRKGYQKSRRHTFSSEVSRRISPSPGQGSLKFQQNSQLIPCSNSLTTKTSNLGPKEIHSSKLTDELIESNTSLEVADSIERANEKTNEKIQPACSQKENLGADEISEKNDVNTVEPKHKKVGQRRYSLKQDFMKYPSNLHMKSRSRKNSELKVEDVLPPNQLFDLGGLCPELSLPNSRHSTLQESSCYLPAEAPTIHFNRNRSLDQADEDSLQDIQIMSDPVDNDSSNSLIVVTTREKGTAYKRSHNSSLKAFSLSKNMSNEILNPILPNKKDYMKNEALLGTKYIWHLRPLSENNFSPKSLHSEVRKADAQKVSISEYKYYKNGRDDFSIPEQEFSGSEEENLNCREESCGFDFASMLPGLQMMESAPMALSTVGQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEL0</accession>
    <name>A0A0B1PEL0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dna mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000539">
        <property type="protein sequence ID" value="KHJ35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEL0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEL0"/>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="160"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="631" mass="70883" checksum="7B162E3762CE56A7" modified="2015-03-04" version="1">MLTVGKKEDLPILCERFTTSKLKTFDDLTSIGTYGFRGEALASISHIAHLTVTTKTKDSNCAFRAHYESGKLIPAKPGQSADPKPVAGRQGTQITVEDLFYNVPTRRRAFRSASEEYNKIMDVVGRYAVHCDSVAFSCKKFGEASASIATQSNSSTIVRIRQIHGSAVANELIEFTSSDKIYGYCASGWTTTANFHVKKTTLLLFINHRLVDSTIIRKAIEQTYSTFLPKGGHPFTYLSLEIDPQRVDVNVHPTKREVNFLNEEEIISQICSDIRAKLAIVDTSRTFQAQSLLPGAGLPHTPASSSKDPEVSNRVGITTPKHKIYENNLVRTDSKLRKITSMLPPSTPGYKLSPSKVGTVEYESSDRELVICRLMTIKELRAEVRNEIHNELTEIFASHTFVGVVDERRRVAAIQGGVRLFLVDYGILCNEYFYQVGLTDFGNFGVIQFDPPLDLKDILILAAQVEKMRVQPDTEDDFDIEEVVETVLNELIDHREMLLEYFSLEISEDGMLISIPLLLKGYTPSLAKLPSFFLRLGPYVTWTSEKECFSTFLRELAAYYVPEQLPSTSEQDDQIDLDDPIETRRREINHAIENVLFPAFKSRLIATKAMLNGAVVEVANLKGLYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEP8</accession>
    <name>A0A0B1PEP8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2185</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01000419">
        <property type="protein sequence ID" value="KHJ35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEP8"/>
    <dbReference type="STRING" id="52586.A0A0B1PEP8"/>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="88"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="57481" checksum="5151E1D6104FC10D" modified="2015-03-04" version="1">MVQVANKAVLIVIDGWGIPSESSPKDGDAITAAETPVMDAFQKDTNAYTELDASSLAVGLPEGLMGNSEVGHLNIGAGRVVWQDVVRIDQTIKKGELNQNSVVMDCFKRAKSETGRLHLVGLVSDGGVHAKQDHLYALLKVAKEIEIPHVFIHFFADGRDTDPKSSKGYMENLLLKIKEIGIGQVSSVVGRYYAMDRDKRWERVEKGLNALCVGDGEQSVDPIKTIEERYAAGETDEFFKPIIIGGKEARIQDGDQVFFFNYRSDRVREITQLLGGHDRSPLEDFPYPKNITVTTMTQYKAEYPYQIAFKPQHMGNVLAETLGSQGVNQVHIAETEKYAHVTFFFNGGVEKIFPLETRDESQDLVPSNKSVPTYDKAPEMSAAGVAKQTCKRIKEGKFEFIMNNFAPPDMVGHTGVYEAAIIGVAATDKAIGEIYETCKKENYILFITSDHGNAEEMKFPDGKPKTSHTTNKVPFVMANAPSNWSLQKSDGVLGDVAPTILEVMGLQHPVEMTGKSLLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFV9</accession>
    <name>A0A0B1PFV9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g5240</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000121">
        <property type="protein sequence ID" value="KHJ36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFV9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFV9"/>
    <dbReference type="HOGENOM" id="CLU_041707_2_0_1"/>
    <dbReference type="OMA" id="YCDVVQL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="342" mass="39748" checksum="790957EED1E01BDD" modified="2015-03-04" version="1">MPNVIQDSDKRVSSFNFPFATAPDVIRAFQKDIFFQDVIFDQFSSLLRRLKGAHLLHAYISQVKTFSELFYLGLTTFIGNQTLGEEYCNIVQIEDTTLKLPAFSRRLGYILTSTFGPYILNKILPRFRVKLRTKLESQLQHLKEDNPKDQKYRKILSYLLENLQAITSPSPIHALTLTMFYFSGAYYQLSKRIWRLRYISTKRIPSSEAHVGYEVLGVLLLLQISVQTWLHLNSTFRIFSSNTNLEEKANDISMTPSEYKVINSNIFNSKPRYDLRTAGFMPWLKGQNRKCTLCLEEMKDPSAASCGHIFCWTCIGDWIKEKPECPLCRREIQMQHVLPLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG04</accession>
    <name>A0A0B1PG04_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000368">
        <property type="protein sequence ID" value="KHJ35524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG04"/>
    <dbReference type="STRING" id="52586.A0A0B1PG04"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="45773" checksum="30BDB8959635C4FE" modified="2015-03-04" version="1">MSNTTIDGRQILKPVTPSKRPITERPTLDSSDRSDSRNAFFPKELADIIAIRQRRAIASFAATDSSPSFPRVPVHTRPNKGGGNSNGKGKDIDKISTKKVAVATPRIILSQGSNLGSSKDVELPRIIPSSDKSWVTIARKGKKKARVIHNAHVASGIKVAQKLSQKHKSASIISDKRLFVRLPLEYEWWKLSPARIREVIVKKLLISSTLIGKIKPVNSGFALSPYRAEVREVILKAGNKFFLSGAKLETATNWVPVLIPTVPSSIRKEQGLVEVSSSMLSNEIERVCSMQPAYVKLYGQNKPDAPHRTWMVFFSKAPRCGFRVFDESGIARPFKKQKPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHASDNCLAATKCRNCGRPHRSDSRECLARPTRSGAPTKQQMRIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG90</accession>
    <name>A0A0B1PG90_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000214">
        <property type="protein sequence ID" value="KHJ35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG90"/>
    <dbReference type="STRING" id="52586.A0A0B1PG90"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="393" mass="42390" checksum="2B3883A9DE93805F" modified="2015-03-04" version="1">MGVQADLAPLKFSTLAVHAGSPKDPSTGAVIEAISLSSTFAQTGLGKPVGKYEYSRSSNPNRDNFEKAVAGIENAKYALAFSSGSATTAIILQSLEVGSHVVSVSDIYGGTHRYFTKVAKAHGVNVTFTSDIQSCLSKEITSKTKLVWIETPSNPTLQLVDIRAVVNEAHAHGVKVVVDNTFLSPYIQNPLDHGADIVIHSVTKYINGHSDVVMGVAAFNSDDLFQRLSFLQNAVGAVPSPFDCWLAHRGLKTLHLRARESSKNADRIAHTLQNSPYVIHVNYPGLTSHPNHDIALKQHRDGLGGGMLSFRIKGGSKAAERFCQNTHIFTLAESLGGIESLVEVPSAMTHAGIPKEERELVGVFDDLIRLSCGIEDVEDLEKDLLQALEKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGJ8</accession>
    <name>A0A0B1PGJ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000049">
        <property type="protein sequence ID" value="KHJ36370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGJ8"/>
    <dbReference type="STRING" id="52586.A0A0B1PGJ8"/>
    <dbReference type="HOGENOM" id="CLU_006468_3_0_1"/>
    <dbReference type="OMA" id="YNEEVNG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="319"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="559" mass="62332" checksum="47DC14CE68D7C204" modified="2015-03-04" version="1">MGPIKEKKSLNIDRAAIDPTLALLFSSNLESETSLKKSCSSPRKLADNLNHIEKQKNVPHYNEEVNGELYNHIKTNPFEDHTKAYALKKNLSGAKEPLFKENSEKIVFHNKRKRKRKLNDENLEAEYMQKLAKQEDKEQKQLEARRNLKNQKLVSEDVDLSDPLGIKDGQSSTSHISPDHESTNFSKKDNELEKASRTVFLANVSTLAISSKKAKKILLNHLGSFLSDLPIPPEGTPPHKVESLRFRSTAYSGTSLPKRAAYAKKEIMEATTKGTNAYVVYSNAYAARAAVKKLNASVVLNRHLRVDSVAHPSKIDHRRCVFVGNLGFVDDESSLDKTDGTLRKRSKIPADIEEGLWIQFSKVGAVENVRVVRDEKTRIGKGFAYVQFTDPNKVEAALLLNEKKFPPMLPRVLRVVRAKSSSKTASVLANRSVKKKLPNTINSAIFNPKLSSEQLSLGGRASKLLGKSGAAKLRTESDTTILSNTIKYPKSGPRKNLSLVGDKTKNLSHGLVFEGHRARSTSVKLKKAKLGLKSKSKRPNTRSSRRASEWKSKNKKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGQ9</accession>
    <name>A0A0B1PGQ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative pre-mrna-splicing factor cwc21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGQ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PGQ9"/>
    <dbReference type="HOGENOM" id="CLU_067891_2_1_1"/>
    <dbReference type="OMA" id="LAHMRPR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="171" mass="20245" checksum="1D77F997F9BF7125" modified="2015-03-04" version="1">MLYHRRSHIIPEIYLVQNMSSNVGLSTPRGSGTSGYVQRNLAYIKPRDRSKPYSLDTESRKHKQRQPDKEILEHTRKREIEVKVFELRDKLEEEGIDDEEIEIQTEALRRKLMKDNKNSTDTRDKVLKISDVHGQAEEKIKQDNRMRNALGISRDYEEGDHWKKQGEKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHT5</accession>
    <name>A0A0B1PHT5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000058">
        <property type="protein sequence ID" value="KHJ36351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHT5"/>
    <dbReference type="STRING" id="52586.A0A0B1PHT5"/>
    <dbReference type="HOGENOM" id="CLU_026434_0_0_1"/>
    <dbReference type="OMA" id="WGGLAEF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="477" mass="53556" checksum="61C374A60B43D53F" modified="2015-03-04" version="1">MTIPVPALITKPWLHGLDLVRGVLGAVSWGPALSVSKAVVTSLFSQITVGQIEILIEETGETMIYGQKIILDRPEVFNIKNNTNETNRCFLKVPKVKLIVKRGSFWLRLLLFGDIGFAEAYMLGDFECSDLVTFFEIFIKNRERLANATTITSSIAATLTSLARSTNTLSNSLLNISAHYDISNEMFAAFLSEDMTYSCPIWKPVVGADMKEDLKSAQMTKLNRIIREAKIKNTDHVLEIGTGWGSFAIEAVSKTGCRVTSLTLSTEQKKLAEMRIAAAGYQDRISVLLMDYRAVPIPKVPFDKIVSIEMLEAVGKEYLETYFSCIHKLLKKDGIAVFQCITMPEGRYDDYAKGEDFIRKYIFPGGHLPSINQLITNISKGSEGTLVVERIDNIGGHYAKTLRLWKEEFLKNFDSHIKPALLAKSENMDEIEIEVFRKKWEYYFVYCEAGFATKTLGDVIITVGREGAMELMEGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHY9</accession>
    <name>A0A0B1PHY9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHY9"/>
    <dbReference type="STRING" id="52586.A0A0B1PHY9"/>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="390" mass="44041" checksum="965C0D9031D0CC2D" modified="2015-03-04" version="1">MSDDGRDLSTKNKSSWTAFLKSIASFNGDLFSMTAPPFILSPVSLTEFSAYWAHHPSIFVAPAAEKDPLKRALLVLKWFLSTLKQHYASRSDKFGNEKKPLNPFLGELFLGKWIDNCGVTTLISEQVCHHPPVTAYRIANKKHGVFLEGYNSQKASFSRTINVKQVGRAILSIKSYDDTYLISLPNLHIEGLIFGSPFVELNDISYITSNTGYTAKIDYSGKGWLSGKKNSFTAVLFPTDNDKEILYSISGQWSKEFEIRVGRKGEVIEKFDAEALPITPLIVAPLEEQSPLESRRAWQKVAEGIQEGNMAAVAEHKRKIEEEQRALRIKEKENGEVWECRYFSPIESDPIVDEFGRDLIHASFHEKRGGAWKFDEEKASNYETASSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIA7</accession>
    <name>A0A0B1PIA7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0197</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000109">
        <property type="protein sequence ID" value="KHJ36214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIA7"/>
    <dbReference type="STRING" id="52586.A0A0B1PIA7"/>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ36214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="365" mass="39651" checksum="FF3EC85EB7AC487E" modified="2015-03-04" version="1">MSAPVLARRCGVLGCTGSVGQRFILLLAQHPFLILHALGASSRSAGRKYKDAVKWKQALPMGSIVENLIIRECRPENFSDCDIIFSGLDADVAGDIETEFLKAEFAVFSNAKNHRANPLVPLVVPTVNISHFDVIPRQRQKHNLKKGFLVCNSNCAVIGIVIPFAALQAAFGPIDKVSVVTMQAISGAGYPGVSSMDILDNVIPFISGEEEKLETEAQKILGQLDIATGEFYKQSDLKISASCNRVAVLDGHMACVSFRFQNREKPLPSVHEIKKALSNYSSEIEALGCPSAPRPVITLMEESDRPQPRLDRNLQNGYTVSVGRVREDLSGIFDFKFVALSHNTVIGAAGSSVLNAEAAIMKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVW5</accession>
    <name>A0A0B1NVW5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005073">
        <property type="protein sequence ID" value="KHJ30118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2348240_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="10931" checksum="DDB5EF1626F3FC41" modified="2015-03-04" version="1">MTEKILKDSLTTGIRDKLRCLNKDSDLPKLDDVISNLLDEDAAQKYNQAVNFARKERQDQSKQQKGKNSNGEFSKSNKSSVCSHCGSKHSKXXXXKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW96</accession>
    <name>A0A0B1NW96_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004688">
        <property type="protein sequence ID" value="KHJ30238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW96"/>
    <dbReference type="HOGENOM" id="CLU_007462_1_0_1"/>
    <dbReference type="OMA" id="MGEITEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="916" mass="95251" checksum="FF4C7A90859F1286" modified="2015-03-04" version="1">MNKSDDIERTPRLPATRLALCSLFLVIGCLIGTQILVPFGSLGNHFHSSTYSDLQILPQSGLEKTPKENAEELLIETLVLFQDLLNQISGGDGSNELHRKRSSKKIARGIASDFSSLLNNFSAGDPPGMVATADKGIADSFSSFIGKLGFGNITGSLSAGAADASKYLGIGLGNGTITGLELPAQYLKLSKVAMEKPSGLNLIASNLGQGLTSSLIGSIDTKSITPDPGMLSLAAKALGEGAGNGASVGLNLKPMSAIVYSNDTGIPAIAGNLAQGLTSSFLSGVDVKSLAMSSMTSVSGDQINAAAKALAQGLGSGAASATKLNPNPPSSDAFDQNGISGIAGNLGQGLSTSFLEGIPFQQLLTNNAPSISPDQISDAAKGLGAGLAGGAVIGLGLQPDSGGSNVPLAPGGLGTMTESFGRGLTQSFLTNGTVTKLLATMQQPNQLDVGSVAKGLAIGLVDGATTGFDNAGGAKNIFNLDSGSTPEVTRLTKPTTYDDTVGGAATGFGTGLGLQSTTFVLQLFGKPPIYQGSDNPNMITSGTPDSKKALADPPAANSSNLQPSRGVIASGVRRRQETTIGSPISSEPSMFNSSDLLNLPQFNGTISPVVQKAIDTLQCQGIGGLVTVLFSVGSSQGVNPSSVDVNDLKEKIGRLGFAKQTIEIQDKESGNQYMVNIAQFDVKVNGNSLVKTIVVLVLHILLAIVAFGVVIPVILIINSIRNLAVMNGRADVLKNSRRIQWILALVVLLPSTLIVLITGIISEGVKSHFTSIHGITGLLLSLFTLPIFPLAYLYLRNKAKTLFNINLGLILTLLMSVLITGFIDLSSLALCATQIIPQTVFISIGSFLSTPLIFSNAFLVLEILMGRWRGKTNDQRQSEMFLNGKSAMKDEERIGLKQPTMTITERNIGEKNFMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWP0</accession>
    <name>A0A0B1NWP0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003655">
        <property type="protein sequence ID" value="KHJ30767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWP0"/>
    <dbReference type="STRING" id="52586.A0A0B1NWP0"/>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="OMA" id="NIAHRTY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="310"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="773" mass="87340" checksum="EDC55FFF14B99013" modified="2015-03-04" version="1">MLHEILLSLSGHSSPLLNNDYSSPSSILSPPEKELLATIASLSNLHCKLLAQTSHITATHDSSICQAVATAVRTKYLSKFQRKVLEVEDSLLNDYNGNDNSTRVYNSIPLTALVGKFSGWTRVMQWLLQTTEFISCGGGNLQTNTNKCSGAMIIDYLRGEIQTGYLDIEEAALSLIKAAETAWLKQLSSWVLYGRLPSFGRDDFFVQTVVDKNLQEFEIKKNLLPAFISDSTAGTILFIGRSLNHIWAKRSLGTKSPELHLLPTHLQQISSLNFPISCANFSRVISSIRLSLSQNILKCLLPLPRVNRILTLLREIFLLGRGEFAVALVTEADERMRSRWRQSQNLGLDNRDNNINILPKEGEVSAVLAKTWAALSAMQGQHDENVEEDEILELARDLMQLTILKPSASMNHHFKSNTMEIYSKISSTPFKNLLLSVPTSLTMNIPSPLDLFLTPADIQVYSCINSYLLSIRRAHLRLTDLWKITAMRRQHPVSLNKKSRNTTASAHLTRMHRKKINERFLTMRSVWATSSAALFFLSETEAYFQAEVVQSIWIGFKEWVNSDIEPSAFNQSSSLNRFDVIEDNYLQVGENLKSLSSGKQSYDPQSLADAHQRYLSTLASSLLLNISAFTHPLYHLLQQIDHLVALVHRIYSIWQSLDLEADEGIVDAFSDFQREEKDVKAQLLLVATKVKNGIENLIINGLRNIEQGQATWDDAFTEVAPFQESQNYVPAKVNRIDRLLMKLDFGGWFNDNTLKRRQNNDHYYLLGESDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWW2</accession>
    <name>A0A0B1NWW2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aaa family atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004192">
        <property type="protein sequence ID" value="KHJ30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWW2"/>
    <dbReference type="STRING" id="52586.A0A0B1NWW2"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OMA" id="KPPTIHW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="248"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="509"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="742" mass="82861" checksum="9EB837CB8F86FB76" modified="2015-03-04" version="1">MSGTVGSEGKIEARIRPYSGNNNQERLDQKGVSRVYLCKEVLTALKLDPGQVCYLSKIDEIGSPIQKREAIIWPTHEKNLSKRVVQVSKTFQEACGFKLGDNVLIEPAGTIHESENVVLKDVTTLISEDTPELEEHDKSHWEWYIRENLGRAEVIFPGMTFRNISLRGPKRTLTIESVNRSNSGIVKYSDKCSIQIIGGKEIPDLLNSSFKSKRLKVVDVSGIDQALLKLNRFLGGFDKEFKVQWAQRSCAVLLHGAHGTGKTFLINKIINCGWTQNIFRISIDSKPSTIRTIFADARNSQPSIIVIDELESIVSKEDTTSQVITRIIGEELDNLSQASSRFLPRILVLTATLHASNIPLTLKKRGRIRTEILLPIPDANARKSILKSLKPPLPPEIYEEVLERLGDRTHAYTAEDLVSLLDAACEIAEERIEISDHDSKGETFYISQDDVEYAFQLVRPTAMHDISLKPPSIRWDQIGGQDDVKKALRRAIETPLQYPERMKRIGASARKGLLLYGPPGCSKTLSAQAMATEIDFNFFAVKGAELLNMYVGESERAIRDVFARARAASPSIIFFDEIESIGSQREKNGRVNSVHVLTTLLNEMDGIEALKDVTVLAATNQPQVLDLALLRPGRFDKLLYVGPPNLAGRKEILALKKRKMDFADDVDICEIARLTEGYSGAELVGICETACDEVMEKCEMTGVELQVQMKDIINAINLVKKQISPEMIASYERWAAGVKTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX32</accession>
    <name>A0A0B1NX32_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003456">
        <property type="protein sequence ID" value="KHJ30927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX32"/>
    <dbReference type="HOGENOM" id="CLU_894864_0_0_1"/>
    <dbReference type="OMA" id="INWARLN"/>
    <dbReference type="OrthoDB" id="3553226at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="35452" checksum="1CBE645BA73C36F4" modified="2015-03-04" version="1">MVSLQSHQSFPTSSYQPFHNAKYHSKPRTIEVSLEAGESKKTPSISSQESSGYSPQTRSKILAHLASTSRPYPLLIRNTNIPLNRQDTQDLCELLYLSGEDRWWEVDLDNVSCQECTKQRSKPTLLDKIPFVSSIAQQIPDSTRHWNTKATRLTECPHDTTISKLMLEIKPEVRARLSCLRITGSFQNPAQVGSAIHNLLRLFPNIQSAQIQLPPVSRGPISEPERIAYHLATLESFLPKGVALKIQNLLEHPDFMVKWVQIKRKWYQLVPCEKEIAQLNKLQDLSDSEGKLLGDNSYSMHWARSNRVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXB1</accession>
    <name>A0A0B1NXB1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003862">
        <property type="protein sequence ID" value="KHJ30623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXB1"/>
    <dbReference type="HOGENOM" id="CLU_2814338_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="67" mass="7536" checksum="6F42F07A6B3597F9" modified="2015-03-04" version="1">MRYNVTTFIKKLENSLIGCHSKTAVKENLMKIVPKLSEICKSQITFLTPKSLKILSSIGALEEILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXK6</accession>
    <name>A0A0B1NXK6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative repressible acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003237">
        <property type="protein sequence ID" value="KHJ31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXK6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXK6"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OMA" id="FPWVNAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079569" evidence="4">
        <location>
            <begin position="20"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="52"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="405"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="454" mass="50604" checksum="8756435D4CDFF0EE" modified="2015-03-04" version="1">MLAPLLFSIVTLVLSVVGASNFNPLRHLAGITPPNDSDAVSSSLDPLPPKGCNVTRAAYLIRHGAIHSNDYEFEHFIEPLLIKLAKTHVNWSTIPNLAFLSTWKNPILSEEQEWLSRSGKLQAMAAGVEVAQRYFYLRTPKRIWSASSKRTVKTAEFFRKGLRSHGNGVSVVKIDEGKKMGANTLTPYESCPAYSKATGSDLSTEFLKIYTKPVVTRFNALAPGFNFTSSDIYAISLICGYETVLRGSSPFCDLSVLSINEWLGFEYTNDIRYFYNSGYGSPISGAMGFPWVNATFDALMSDQNKQSDKVEDQDLYISFTHRHLPPMVLVAMGLFNNSAYSGSNKAQQTMPLHTINHQRVWKSSQILPFMTDVGLEKLECDSHDYDKGTYYRVLLNNNPLSIPDCHDGPSESCKESTVVKWLSGRAKIVGDFDTACNVKYENSSNILTIYKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXR4</accession>
    <name>A0A0B1NXR4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf2347 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003658">
        <property type="protein sequence ID" value="KHJ30758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXR4"/>
    <dbReference type="HOGENOM" id="CLU_019791_0_0_1"/>
    <dbReference type="OMA" id="GYTIVWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="1">
        <location>
            <begin position="436"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="616" mass="69664" checksum="A5C43459420D9616" modified="2015-03-04" version="1">MAVIRRRQALLNIDLPSHIIKSDLCPLSALFLIYFDNKAGYTISWKRSLPGVEVEGVVEYKSLPSGVHSVKRDLIYFIHGDYAGLSAFINAPVAEESRNARMIAVGVLVPVSGETLGRCWEHAEELKEMANNLIDDTKKTQILEDYWEKHKVQTLPLKSSILQLPSLSRTGFKSLPNSPLQARSHHRGRSLSDSQLIHSDMHTLSTHHPAWSMVKLLETFGPLIFPIYRAALLRQRILITTHAPVQETCNFVYDISILSKIPLDGHHILEQYGFSQSLRPLFSIGVQDIPFLEEEFERLKTISNAPQSRHSNRKDIPSRGWIACTTDSILAMKHVLYDVLVKLPSPCSSSVDEKLWPKLESPPGIELKATQRDLRRYKALWNSLLLHKSSLEDATQKRSSPANYSNESNISHTLSHNSTNLYNNTLSGLPGMGSIIEPVSWSALAYSNFSWWASSGEIKSEIFNESESDPLLLSDISLDPQLVPSNFRMSPFKNTDTILEYSRRSPDAPASLEATIVTYFYRMTKQILSTLENITITSDLEEDQFDENNPLQGNSENSEYESRKPIIISRADLVKMGLDLWSDSDHQFIQKLAREYIGRRSLIESPRFQICGITIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY42</accession>
    <name>A0A0B1NY42_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003495">
        <property type="protein sequence ID" value="KHJ30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1653448_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="160" mass="17827" checksum="7EF986D31B84D512" modified="2015-03-04" version="1">MKVPAKSQSSPPRGTGVNSQYALHVWDSQKDSHNPSLQDLPPSPRVSVVFVSTSLSPQHLFSRSPHDWXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAGNLWVTVNALLPIQPNVTSDWMPYWEKLGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYA0</accession>
    <name>A0A0B1NYA0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative n-acetylglucosaminyl transferase component gpi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002995">
        <property type="protein sequence ID" value="KHJ31322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYA0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYA0"/>
    <dbReference type="HOGENOM" id="CLU_007914_2_0_1"/>
    <dbReference type="OMA" id="HPTRMQY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="718" mass="82995" checksum="9B08593C18C7D46E" modified="2015-03-04" version="1">MPEHDGLMRIFWPYDLSRFVSPGTIVGWRNSGLDIFIVSILEDVDTRTIQDALKAGALIRNASHPVTRIFDLCGKSSMQVLGVTNSPNIDVDNLQIHAFTKPKLKLPQVSCARASTIQVIMFERPLPNRMQYISLEPISLALGDKVDPKNEAPDLVLTDDEKDKMKERRKSKELVAKLKLHTVRKHPASSKERALLNIVNQINCSWELDRLLQKNVLQLKKFPRRSLSVSERVVESAMTMRDYVIKATWKLIINYIYPMIKKFFIIVLICHRIFAEAFLVVLEWRMKPDYAALKDISATAQQVDIRLQQFCYWPMQYVMLRKRKYDWESVTTSHPDYIRFYNSLWLVANDVIIGIALGSYIIDNSTWVTENLSETLSMYSIAALQNTISWLMDWPAGLKLNNELAAFLGDLFLWVIDYWSNFFGALKPILPKIIWFVGFSSFAGASLPISLFSDFISVLTFHIYCFYMASARIYNWQYSILQSLFQLFRGKKHNVLRKRIDSCDYDLDQLLLGTILFTLLFFLLPTVLVFYFTFASFRMAIITLKALLDTLLACLNHFPLFALMLRVKDSKRLPGGICFELQDTESPSHNVLRIRKPKDNTIIDNSLNVIPTSYIFLKSVPLKFRGMFQQYFQLGQRIRKHYLSLRVLLCLVTGRFVPPIHRKNLYSLQYTMLPARRAGISEMWTVLTKNESLSKLHSGHEGKLNGRRLNGYGHGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYC6</accession>
    <name>A0A0B1NYC6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01003384">
        <property type="protein sequence ID" value="KHJ30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYC6"/>
    <dbReference type="STRING" id="52586.A0A0B1NYC6"/>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="40889" checksum="598504CD0F4FF937" modified="2015-03-04" version="1">MTSSLDYLPSSVTDAVLVASSEMPPGSRKVEELDFNKLDKLGSITVDQLVSGMANMGFQASSIVDAVRIINDMREWRDPLNSDNRSTIFLGYTSNLISSGLRGTIRYLAQHSQIAAIVTTAGGIEEDLIKCLSPTYVGSFHLNGAKLRSQGLNRIGNLIVPNNNYCLFEDWVQPILDKLLKEQEESKMKDKPINWTPSKIIKRLGKEINNEDSVLYWCYKNNIPVFCPALTDGSLGDMLYFHTFRSSPLQLRIDIVEDIRAINTIAVRAARVGMIILGGGIVKHHIANACLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKIGADAVKVYADATICFPLIVAATFAKDKTLLLRDSNVARKNPCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYH0</accession>
    <name>A0A0B1NYH0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative srf-type transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003334">
        <property type="protein sequence ID" value="KHJ31023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYH0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYH0"/>
    <dbReference type="HOGENOM" id="CLU_063931_1_0_1"/>
    <dbReference type="OMA" id="DPQAMAY"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="225" mass="25298" checksum="B4FAEAEAEF01D7DA" modified="2015-03-04" version="1">MADVTDQNDQGSPLKLEDIEGNSIPIPGDENHGIKRQRPPTVENTQEEEEEEDKPGRERRKIEIKFIADKSRRHITFSKRKAGIMKKAYELSILTGTQVLLLVVSETGLVYTFTTPKLQPIVTRNEGKNLIQACLNAPEPIGENGLDDPNADNAPDDSPSQQHQQNRSGMPQQSTNLHSYNIPTSLEQQQQQQQAIAYQNYLSQQQRSGYPIPQTAIPQQHTHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYM2</accession>
    <name>A0A0B1NYM2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003282">
        <property type="protein sequence ID" value="KHJ31078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYM2"/>
    <dbReference type="STRING" id="52586.A0A0B1NYM2"/>
    <dbReference type="HOGENOM" id="CLU_022271_1_0_1"/>
    <dbReference type="OMA" id="FDAKFFQ"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="528" mass="60418" checksum="D4BD879F1C91B366" modified="2015-03-04" version="1">MRHEMTLNHAHYERLSRSSSDLFHEALDVEFCEKPIIYRYFSLQFRKTRRLFSLIRKSFNFLSFFLLLLGIQLIFNGSYTESNAPKFMPDAQEKVFIAANIADGDLIDNSWGPSLLSLVDLIGVDRVYVSIYGYPTAQLLQLAGMLKCEHNIVSEELEPINLDILPRILLPNGDQRIKRISFLAEIRNKALQPLAELERKGQKFDKVLFINDVFFNPSEALRLIWGTNVNKHGKAEYKAACAADFITSWKYYDTFATRDAEGYSMGLPLFPWFSSKGLAASRKDVLAGRDSVRVKSCWGGMVSFDARYFMSTEQENSEATSNSIRSLNTKFPVRFRSESESFWDASECCLVHADIMALPSFYSLPVAVDNLNTGIFMNPYVRTAYSAQALAWIPFTKRFERLMAPIQLTINWFAKMPRYNYRRTEEPGQVIVDRVWVSYNTNQNATNKGHGNSSSYLRHSRSHSLGNPSTLWHQQGYYKNVERASKNGGYCGVRQLMVLKEAGYTHENNNKGGKNWDNLLNSVPPLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYW3</accession>
    <name>A0A0B1NYW3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003158">
        <property type="protein sequence ID" value="KHJ31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYW3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYW3"/>
    <dbReference type="HOGENOM" id="CLU_023536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="574" mass="64762" checksum="FBCF015CF1E37EE5" modified="2015-03-04" version="1">MISDESSDLSSAPSDTECDLQLTKKDGLLKFFTKIVPANENDDFTKNLKREPSPVHEYILADNQDIAFIVMFRSRFTEAFPKSLVNFGPQELEQDVVQTIPGEGVESFLCALLGLLLNRKQEVKSGHYNRALEEAIQSHKSQWAKDWQNKTPLSKGATFSSMTPEQRLTLLRTLILWALSSSETLKGIIQSSYKQQRQEDDLNQPLSVQPWGSDSNRQRYYLIEGLYDTQFRVYREGDYMGPERTWYSVAGNIEELKALADRLQLKDGGQKARLLSSKILAAIPRFEAAEEKRKRKEYRTTRKQFFKRADPDYSIYEGRTRGKRIKYTFSDEDEENLADLNSTRRSMRSNGNNPKFDNNVPAVTQSGRQVKSRQGGAYGETIPSKICAPTSSNIDINNDHYLNTNYGQSKIDDKVSNNDHSPNRSRDTPTKICNGVIELGTEGDDSMVQDSNDGDEAYLESEIDASEDFSDEYDERFDDEPKKINVRLPVQSLKSDKKTGVNLQLSLMKEVSKTTACAVTKYGNNKKCSGTPSASHINKTPCSTELTKNFNNSDNATDTTPAQNITKPHSPLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZC6</accession>
    <name>A0A0B1NZC6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004363">
        <property type="protein sequence ID" value="KHJ30380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZC6"/>
    <dbReference type="HOGENOM" id="CLU_1035096_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="31414" checksum="8FB5F433128C7B78" modified="2015-03-04" version="1">MDEDRSEKGTGLWKLVPVLTKVNKTEWFQLVEQVLEGDGSQWLLTHTNKEYAHVRDSARVVEPDAKWTSYTTEDEGENVKWWILPDKDLEYKKAQINFRLNIRLKISEIDKDMMDEKVGIPAQFACLKRRYNLVSYTTGAGKIVAFTTWQMNVELNPSTNYTQLSKLRKEVHQFSPGTKFSTDFMWKLFVAGLRPRHEYMGLAEGFPPSMTVVERLDRLDEKWSFIREETRSKENSFRASELVQSSYFDEFVLSLCRNRVPSGKKGTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZF5</accession>
    <name>A0A0B1NZF5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZF5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZF5"/>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OMA" id="NPHGGKE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="178"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="320"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="465"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="638"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="825"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="984"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1120" mass="128316" checksum="1CBA0FD25A6ACE49" modified="2015-03-04" version="1">MSPSASKRRKLDLQNDIKNKHESHSSVGLNDSIRKNQDHSKSPSPERDFKKIHSKQRHDSRENLQFIGGEYGTSLFKLQVDELMREIEPSYEKKFRGVEDILDQLKSLIEKAEPQELQSISDASRLLQKSYGVTVPYPNPKPDKDLAYKVTFAKPTSINVVGSYILKTMTKSKSVLSIDMIVVMPQSIFQSKDYLNYRYFYKRAYYLAYLAAKLESSSKERFEYNFEHLHGNELHPILIARPKIMSTTYQIRIIPAAPETLFPLPKLRPSRNSVRPRKGNDSEIKELTSTPFYNSSLTSDCNIESYFKFLHATSKNATGFKDACILGRIWLRQRGFDGSIRGGGFGHFEWAAMSAILLKGGIPKDFLALSSGYSSFQMFRSFLQFLSKSDLTIKPFVLNKNEIGIQKSNTPIFYDSPREHNILFKMSPWSYKLLRLEAKTTLDMLSDNNIDHFDSIFITKISQPLLRFDYVFSISQGSQKFQNTCADHVPEIKNFSNRLYRVLEKGLKDRVKLIYIKEHPSITWPIKSSASSIVDESVTVSVLFDPVNVNRLVDYGPSAEEDIESAEFRKFWGQKAELRRFKDGSILETLVWPAGSTQSIFETIVLYLVERHWDLKTAKNIKFMGGGMENLLPDLAIDQNQYNALQDAFKSLEVQIRSLEGLPLQVKHLSAVDPQLRYTSILSPSFGPGRPMNRPADVLIEFEGSGKWPDDLTAIQRVKASFLLRIGKLLEETNKNIKPRLGLENENQYLQNCSFLDVIYLDGPVFRLRVHCDKEQTILERQIKNKSTERHLRDEAVLALSAYKRHYVQLPLLTQSISIHCTRSPLLSSSIRLVKLWLNHHMLCRHFSEEIIEMIVARTFLKPHPWQTPSSITTAFLRTIFFLAKWDWRTTPLIVDFNNILTNVQIGSINTQLEAWRKIDPALNRTVLLVASNHDLSGTAFSAYNPSKMIAARMTALARSASNIVKDMEYELDNKLLFTTSLIEYDFVIYLSDKYTSNYQKGKSSKVTLKNLDLQSEKILKKVGYHPIQLYLKELETLYSNTIIFFHEMLTGSLIAGLWDPQFLQPRSFKVNLSYSTCVRENNEEPGAEVVINQASILAEIARLGGDLVSKIVTQKSQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV2</accession>
    <name>A0A0B1NZV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002829">
        <property type="protein sequence ID" value="KHJ31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV2"/>
    <dbReference type="HOGENOM" id="CLU_474851_0_0_1"/>
    <dbReference type="OMA" id="EANNINC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="554" mass="62776" checksum="F9FACB22454E68EB" modified="2015-03-04" version="1">MAATYYQDNSVRSLNIDHDDLEPLEWDPSFLDISSTDESPEPVTINSQPVTYTTVGSLVDPKAILQFATPSRIQREGANRKPLMSLLANRPFDSVFQSFEFTPPKPSYSIRYTQKSSLAPSDKDQNLSLNLELNSNSKNLPSSIESPRDLLKATQHEENCIIEKNGLLPICSESKAVKNQLLSLDSESNSTRDTISKDLGGKANGPMKHLSSGHQVLEKMQTLQRLSRFNNPIQEWAQNKLSEFAVNKKQIYQKNSPSSASSHDSLLYSCGQAHENQAKYPELEDLRYRIGHLDIDNVLHKFPKQLRANRNQTQSNVVSTRSLSYPHNYPQPLTAGPPGQRQSSLNFSQSCSSLNQQPRHFRAMSFESLPRDQMNNFRVRRIPYQHKHILPWAGHTSSDLVDTLTTADAAKYYPFAWPSGSLEIRTVNNPMCFAIQKFQIKNIDNSNDYEWFYSGQRRYASMVSQCERINGDKGINQNDIQRSLSQLKTSQAEFSRLSIMNFNGKSLSECVAPMINILFLNLLEYSERRSPGSRTALSNYIESSILSFDSSNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW9</accession>
    <name>A0A0B1NZW9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003934">
        <property type="protein sequence ID" value="KHJ30585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW9"/>
    <dbReference type="HOGENOM" id="CLU_1476208_0_0_1"/>
    <dbReference type="OMA" id="MATSMEC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079598" evidence="2">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="183" mass="15429" checksum="14FB7E7E7208AE39" modified="2015-03-04" version="1">MQNLALLLAVLTATSVVAQKPDGGSSSPPSQGAPDGAPGGGPGGGPGGGPGGAPGGGPGGGPGGGPGGGPGGPPKGAPPPPSASGGPPRGAGSGKNSTGPGATASGPGAAKSTGGPKGFGGGGGGGGGGGGGGGGGSKTNDTKGTPAGGPMKATQTAGVVGPLSQSGGLVSIAGLGIAFAVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX5</accession>
    <name>A0A0B1NZX5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004797">
        <property type="protein sequence ID" value="KHJ30206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX5"/>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="54227" checksum="274E08E32A866D39" modified="2015-03-04" version="1">MPPLHTGHSPNLSIFLKSLKSTPIQSSIENFISLLKRRQIHGSRPCAIATAHLLLHTVIKFKWTDVGKLLELIAEVGQRLIEAQPREVVLGNIVRRVRHMIKGEAEENRREIDSDSISIDQAESPHKDASNSVSLKAGLVPKTNSLSSLATAGDIRLKGNFNSNTLNINLQRISKLSHISLTSSNTPFAVSNGIVMPQTMFNLLSTTNSPYATPPGTNSSLKSVVSATSLARRIDKTTKDIKAEILTGIREIIDELIQEYDLIAGYALEHIHSNEIILTHSFSQCVHKFLLKAAEKRKFTVIIAESYPNRHDAVHSAVMGICNDDSEEDGDMDTKSFLEPLSAAGVTVILISDASVFAIMSRVNKVIFATHAVIANGGLIADAGARIIAKAAKVHRTPVIVVSGVYKLSPEYPYEVESLIEYGDPGKVVPFDNGVLVENLEIDNPVYDYVPPDLVDLYITNLGAHAPSFLYRIVADHYSNEDQDPNKYESLWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P036</accession>
    <name>A0A0B1P036_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fggy-family carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003807">
        <property type="protein sequence ID" value="KHJ30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P036"/>
    <dbReference type="STRING" id="52586.A0A0B1P036"/>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="335"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="617" mass="67669" checksum="31A0FC196E4F980F" modified="2015-03-04" version="1">MAQSLPLRQAVRKTSRKASIDPHNDINPHVDHYIGIDVGTGSARACIIDCSGNIKALTTENIGLWTPQTGYYEQSTTNIWRSICTCVQRALSLHNIDPDTIRGIGFDATCSLAVFSHDTDEPITVTGPNFTNDGNDRNVILWLDHRPEKETEKINATNHNLLRYVGGKMSIEMEIPKILWLKNNMPPNLFDRCKFYDLTDALTHIATGNESRSYCSTVCKQGFVPVGVDGSVKGWQEDFYKAIGLEDLVKDNFKRMGGVDGVNGNFLSAGELTGRLCEKAATELGLPPGIAIGSGVIDAYAGWIGTVGAKVNLGEQQVVSGSSVNDISQAFGRLASVAGTSTCHLAISKDPIFVDGVWGPYRDVLFPGMWLAEGGQSATGELLKHVLEIHPAYNETISISESFNTSIYDYLNSHLDEMRLKLKAPTVSFIGRNFFFYGDLWGNRSPIADSNMTGSVVGLSPDKSIDGLAIYYYATMEFIAMQTRHIIETMNKSGHSISSIFMSGSQCQNKILMELIATVCGVPVQIPRYVHAAVVHGAAMLGAKAASADENNKTEDLWSIMDRMSKPGKTTLPGKDENEKKLLDVKYKIFLDQCKTQNTYRKYVQDAIGNWGSEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E9</accession>
    <name>A0A0B1P0E9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002316">
        <property type="protein sequence ID" value="KHJ32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0E9"/>
    <dbReference type="HOGENOM" id="CLU_021601_0_0_1"/>
    <dbReference type="OMA" id="GMGSWAV"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="52145" checksum="0B720CAA6B59198C" modified="2015-03-04" version="1">MPTHNLMSSSGRGITSIPLISISRSPSPSLRRHTELNPQCSVDGEDDWDTGIRTPFFSNDSTKDHGWRHWIYNGGSGHFLFNTPTGWQLYTSTLILWLGGCQIGLILMNRIILWTGVYKFPYPLTTTFMELLITHFFVTLSAYITRWVSPWLVSAGLSSGIAPSRPLKIASPIGFRSGSRLLAPIKIWLQKNEGGIAGGGFFEFDPEVARLVLPCASIFVAKICLSNLSFAYAQLQIYFLARIATVPLSLLFTYLLARTSYSVATISSVLTATLTLLIATARTNVRVTWESIVAGILSSIFVVLYPIQIQRTYQALVSQIISQGEHFNSSSSIRLNSPSGSSEETRAYWRLLHYTSILSMLIFIPIILLSGEVGNIWRNCYTLDVFFHWLMILCGGLGSWAVFWATIALTRATSPFTVTSLFIPRAAFLLPIISGWQMPTHSWVGLVMCWACCLWLWISRNREAPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H1</accession>
    <name>A0A0B1P0H1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative centromere binding protein cbh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002283">
        <property type="protein sequence ID" value="KHJ32157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0H1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0H1"/>
    <dbReference type="HOGENOM" id="CLU_1054464_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="264" mass="30555" checksum="CB011C123F7DC507" modified="2015-03-04" version="1">MARKSILKRERRELRAWYIQQQPRPSHRECITWFEEKFHQKLTQGTISKSLSHRYSHLDDYNASSIAENGCRTRTSKWPILEKLLFEWQQSVEAQRDGSASVTSDALVAKAMEIWPQIPEYRDQPQPLFSSGWLTNYKTRYNSKTQQQSQHQQSHIEANQLNTASTNNEVIMARDLPTLSFDVANSSLSNPTLDTPCSRRAPEIRVPTPHEALKGLQTYLMFKACQEDSKPIELRSLILQEQQLQLHIENTTKQSTLDSWLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I3</accession>
    <name>A0A0B1P0I3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004284">
        <property type="protein sequence ID" value="KHJ30421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0I3"/>
    <dbReference type="HOGENOM" id="CLU_510175_0_0_1"/>
    <dbReference type="OMA" id="ISHRHER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="534" mass="60872" checksum="E461DCB4BEBDF36F" modified="2015-03-04" version="1">MAGSQNVISQIGNLLNTLSNRDPSPSRKSNRTHEKHRKHDHSRKNENKTSNYSDEMIRDQSIPQRWDAEHHSREQEYDHHLIGAEQLSPFKRPMSQVRNREGSLNEEKHRKFPLTGQDQNHHRRRRQTINSEQPFLIRDNYTSKNHEQGQKFHSPSPPRSESFNRQTVLRHQSSLDTFDRKRQVLSKMAVEYTSPTKYHGSFLPPSVPIPLPVRSVPPSGKYSKKTFDGYYQGTERHLPVDQGLGRYSGFDDGNHSSKHRGRRMIEEAKLYHSPNINLRESSTDSSWSSGSYSSIGSEFPKRGKTKIPAKLVHKLAIIELGYPFEEEGDLITILNALGRKNIDELINLSEKYKADEKSTSKEHINVYTVPYTSQLNNPVIEYTQTSPPPVSMPLLPATQVPTTTYALVPPASTCVASVSFQNPICETNKSKQNFVGLQHVKDERTFNAEIKALEANKEALLTQRRTCQVPYESQGIVVLRDEGGCDGYREDAKAVRHEGKNLTPKGKSSSRNGRPRIVRDRKGRKCIAVPRNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L5</accession>
    <name>A0A0B1P0L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fmn-binding split barrel-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004434">
        <property type="protein sequence ID" value="KHJ30349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0L5"/>
    <dbReference type="HOGENOM" id="CLU_056802_1_0_1"/>
    <dbReference type="OMA" id="ITLSMRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="1">
        <location>
            <begin position="101"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="285" mass="32387" checksum="111AD2F39BF75086" modified="2015-03-04" version="1">MYFYSVPLTSFIVFALNIRQIICKPIVSNRHDNNVSHAARIPTPQESAVLARRILRLTPLATFSTIFPSISQSNASSSKESFSQKALHAYHVYPVEEHRPQRLDNTPIGLIEYVADCEVSGNPTILAINIATTFRNVAAGSNVSISFSWTPPPLSPWSNIISNIQRTSSYSAANLPRFALFGFLERIDPDEVEELSIEECFLKTHSDAKRWLPGNRIHTSKWQRFVVENIYWVGGFGDRAYIGWIPVDLWKSVMEDDIDRVRLPGEKQGWKEMINKWLGSKYSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Q8</accession>
    <name>A0A0B1P0Q8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004091">
        <property type="protein sequence ID" value="KHJ30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Q8"/>
    <dbReference type="HOGENOM" id="CLU_100328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061701" description="Secreted effector protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27168" checksum="CFD7403715AB5567" modified="2015-03-04" version="1">MSSAILVLILISLSFSAALTPTKSIVLIQNSDSAKCGPFILPAIFLQRQALEICKVEVKYAKCLLSKCSLPRITNRPTYYKGNLFPNEKAPLIEKILQSDVYLRGQKISSSYIIVKWDMTSKICSRVGVLHKFLNGAPFVVCQSFDPKKSVLRVDLDERRKRKSISDFLHEIPEDVPNKSKTLLEKLLGGLSNDQLIWDPGFGMSQLTLASAMRRLLNRSIKAIQIAFSRQSRNLHLHAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S1</accession>
    <name>A0A0B1P0S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative hsp70 nucleotide exchange factor fes1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004288">
        <property type="protein sequence ID" value="KHJ30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S1"/>
    <dbReference type="HOGENOM" id="CLU_084507_0_0_1"/>
    <dbReference type="OMA" id="LKWSVEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="7">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="230" mass="25140" checksum="8A46287583E011E7" modified="2015-03-04" version="1">MVTNISVLKENNHYPNSHHSMNPNLNELLRWSVANSTNPPDASAISNQGLNPNSLNALFGGPTDAELMITSMEAIRSSNPDVKLEDKLVAFDNFEQLVENIDNANNLESTRLWGPLLECLDHEEGGIRKMAAWCIGTAVQNNIKGQEMLLAKAGLPKLVKIATAEGEATQVRKKAIYALSSACRNYQPAMDVLTDELRKLGKRSASVDAKDMEACDELMEALKEAAFANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P194</accession>
    <name>A0A0B1P194_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative proton-coupled oligopeptide transporter of the plasma membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002413">
        <property type="protein sequence ID" value="KHJ32003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P194"/>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="OMA" id="GRSMTRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="749" mass="83793" checksum="0BE9C4A23122E2C1" modified="2015-03-04" version="1">MASVETKSSLKDESYEDQNSNYSSTISHTALNGLHTDDDPTLNPWTFRMFLIGLGLSAFGSTLATIFLFRPQFVTVSVIFLAVISYFAGNAMSRFLPSKGLIGRWLNPHSFNSKEHIAIVIMSHTASTAAYATEVLAAQKLYYDTIPNSLVAILLLISSQLLGYGMAGILRSGLVYPTKMSWPQILPLSSLIETLHRDKIEMKKKAVFFWIIFVLIATWEIFPQYIMPVLTGISVFCLANRKSLVFTKVFGGANGNEGLGLLSLCFDWQYITIAPFFLPLITLFNSFIGNIIGFGLQIGLYYGNIWNAKSFPFLGQQLYARSSNTTHYLVYNQSEILDNKNQLNVTALTVKGTPYFAATHASYLLTTNLSIGAMALHILLWNFDDLRQTFRGLHLPKMKSFKLNSFFKQKREEPRTEAELAKLDPHYRQMLVYAEVPSFWYLGILIGSFSIALFSIYSLKSTLPWWGLVVSCIIGFLNTVIISILAGSIGFGLPTTSVIQMIGGQLFPGKPVANMYFVLFGANTQAQALNLISSLKFGQYGKLSPRCTLTVQTIGTVFGAIINFFVMSTITTNRRDILLSTQGTNVWSGHAVQSFNSNAIAFGALSKYLFGAGRRYQFVIFALPLGCLIPLPFYFLHKRYPKLGLNYLVTPVICWFLGDLTGGINSSTFMFYSIGFFVQLYIRPRYPKWFMKYNYVLAAAISGGTEFMVFLSTFALQGASGREVIFPKFWGNNFQQGNYDYCAKDPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1R1</accession>
    <name>A0A0B1P1R1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001965">
        <property type="protein sequence ID" value="KHJ32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1R1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1R1"/>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="162"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="28828" checksum="93131B62B05329F0" modified="2015-03-04" version="1">MSAPTSLLQNQREILPSPSNLPLSIADQNDTLILDTHNIEPNIITIDQTGQEDTEMHIDEEGRPRFAPAKFAESHIRVEVRKVAIPPHRMTPLKAVWPKIYPPLVEHLKLQVRMNIKNKAVELRTSKHTMDLGALQKGEDFVKAFSLGFDVDDAIALLRLDDLYIETFEIKDVKTLHGEHLSRAIGRIAGKDGKTKFAIENASRTRVVLADSKIHILGGFKNIHIAREAIVSLILGSPPSKVYGNLRTVASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1T9</accession>
    <name>A0A0B1P1T9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cell division control protein cdc48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003061">
        <property type="protein sequence ID" value="KHJ31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1T9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1T9"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_1"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="253"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="527"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="820" mass="89842" checksum="C336B34114C60DD5" modified="2015-03-04" version="1">MSEDNATRKKTVKLEDASGAEQKTIDATATAILKKKKKPNSLIVTDAINDDNSVIALSNNTMETLQLFRGDTVLVKGKKRKDTVLIVLADDDLDDGSARMNRVVRHNLRVKHGDIVTVHPCPDIKYAKRIAVLPIADTVEGLTGSLFDVFLAPYFREAYRPVRQGDLFTVRGGMRQVEFKVVEVDPPVYGIVAQDTVIHCEGEPIQREDEEGNLNEVGYDDIGGCRKQMAQIREMVELPLRHPQLFKSIGIKPPRGVLMFGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILQIHTKNMKLGEDVDLEQIASETHGYVGSDIASLCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRFALGISNPSALREVAVVEVPNVRWDDIGGLEEVKRELIESVQYPVDHPEKFHKFGLSPSRGVLFYGPPGTGKTLLAKAVANECSANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKSRGGSVGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDNALCRPGRLDTLVYVPLPNETSRVGILKAQLRKTPVSPDVDIAYIASKTHGFSGADLGFITQRAVKLAIKESISLEIQRRKEREAANEDVDMDEDLEDPVPMLTKAHFAEAMASARRSVSDVEIRRYEAFAQSMKTAGPGTLFKFPEGGNTNNSAASGTGGFGDAGNDDSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1U4</accession>
    <name>A0A0B1P1U4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sir2 family histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003641">
        <property type="protein sequence ID" value="KHJ30779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1U4"/>
    <dbReference type="STRING" id="52586.A0A0B1P1U4"/>
    <dbReference type="HOGENOM" id="CLU_021544_1_2_1"/>
    <dbReference type="OMA" id="CEEHEGV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="512" mass="57017" checksum="397E6CCD9C8040CA" modified="2015-03-04" version="1">MSCSPLLPSVPNALPSPLSSVDSRSQSPESKICYNIPTEFLSNFQKISEKRIFKNESKDCAPPAKRQKITKLRNMKTEYLDLVSLNQSNDEVYHKMQDPKLKKLLEIFRTKRKIVVFAGAGISVSAGIPDFRSSTGLFKTLRGDFKLKTSGKQLFDADVYRSNDATSSFHAMVRELSRKTKNVKPTPFHDMLATLAEEGRLLRLYTQNVDGIDVRIQPLATNVPLNVKGPWPKAIQLHGGLGKMVCSKCSHLADFDASLFEGPTAPPCSQCEEHEGVRKAAGLRSHGVGRLRPRILLYNEHNPDEDAIGAVSFADINKGPDAVIVVGTSLQVPGIRRLAREMCLKTRGRKNGFTAWINHDPEPSGADVKDCWDMVVRADCDDIARIVGLPKWDDKDCGEYTVFENRSAPLVKNQCHVVVHSKPENLMRQKTPTISDPPKIQAVEPEATMRSNGLNLKQSIIKISSHPIMSEEIKNKKPGRKPLPSRPIKSTPKIFSNFHVTKTARSAHRTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X2</accession>
    <name>A0A0B1P1X2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002225">
        <property type="protein sequence ID" value="KHJ32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1X2"/>
    <dbReference type="HOGENOM" id="CLU_001650_10_3_1"/>
    <dbReference type="OMA" id="EDLECWQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="118" mass="13384" checksum="0C0DE66CA59C329D" modified="2015-03-04" version="1">MATLRAFLSIVAAEDLECWQFDIKNAFTESEMKEIVFLKPPKGVNVTKGKSLRVLRSLYGLKQSARDWNQLLHSQLLSWGFIQSLADPCLFTYKEKCLVALVYVDDIAVSGKNLDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X5</accession>
    <name>A0A0B1P1X5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001899">
        <property type="protein sequence ID" value="KHJ32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X5"/>
    <dbReference type="HOGENOM" id="CLU_067132_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="217"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="387" mass="42628" checksum="5FD6D6ABB69A35EE" modified="2015-03-04" version="1">MSFIGPKLCPQSLSRDDSAKSASPDGSPRANRTIGPCLPKDGYSTSVSHDKSKDLDSEISTDMILQPTPLLNSNTDEVQDSLQLKSQHGCQTGNKHHSSANHPEKSIVLNGDNLSNSVKPTTSSPMRRIFGAALPPAIRSEFVSNPIDSSLNSIDGDPSDSDSDDDYGPSLPPAQTPMENCSITTEETTKEKPYNSRTNAKSNSTSKLERAEWMLKPPDSLDLTSRIDPTKLKNRKFTSGRGIKRPADGSGVSAIWTETPEEKRKRLADEVLGREDATSASSLSRLAKSNPSQVSCNARISKEIMATKEKINEFNKLNRNKSLLEERKAAQDRGELELLEDDDPSHRAFDREKDMSLGGRHVNTANRKQFLMHAKNFGNRFQEGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A9</accession>
    <name>A0A0B1P2A9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001818">
        <property type="protein sequence ID" value="KHJ32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2A9"/>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OMA" id="FNVMKPD"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="297" mass="32370" checksum="BD28BD3E7151F5C9" modified="2015-03-04" version="1">MMEALDLGMIHSVMVSVAYEAGSIMLLERPSQSESDIKKNSADIVTETDKAVEKLVSSKLLSAYPDFQFIGEETYYSGQKLTDKPTFIVDPIDGTTSFVHNFPAFCISIGLAVKKTPVVGVIYNPLLDELYAAIQGQGAYLKRGSSSDKQKLPLRKAEPLNDLSKCLIGIEWGSDRTGINYELKNNVFTKLAASKEDGGAMVRGLRNIGSTALNLASVAAGQQDIFWDGGCWAWDVCAGWCILVESGGMVVSGNPGEWECEVESRKYLAVRGAPSGQRQIIDEFWKVIGDGRLEYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2B3</accession>
    <name>A0A0B1P2B3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002862">
        <property type="protein sequence ID" value="KHJ31485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2B3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2B3"/>
    <dbReference type="HOGENOM" id="CLU_000288_144_6_1"/>
    <dbReference type="OMA" id="PEFDCTI"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="591" mass="65949" checksum="79F2EDAC963C6547" modified="2015-03-04" version="1">MAAQNALHRKDSLVGPPLRILSIDGGGVRGYSVLIIIQELMYRTYVEIHGKAPKRNQIPKPADHFDLIIGSGTGGLIAIMLGRLRLDLETCKEMYIRTSRKVFESDKRIAGIPYTSTLFKASKLEEAIKQCVMEHTILKSEGNDGAEPPAVDNFLTNSMNNLIRGRRYHSRNSSMVSLSTRVSRSSSNPPFSVADLGNPDALLYDKRENRTKTAVTAVYKGTPRGGQPALLRSYDSRKEPPPEFDCKIWEAGRASSAMVLAFKEIQIRQSVFLDEGSGKFNPSPIALEEACVNEWPCREVGVFLSIGTGKRPRGSDMNAYLWYEGFLGEYADAKRRMISKIEGCEKIHEYMLQECLAKYGVNPENYYRFNVEVGVGEFEMNEWTRLADISTSTRRYLGKPDVQRQSLRAASRLAAIHKAKIRNESVLNNIISKKQSILSDTIPDIIPEPHLNAVELPAKAPAYIPYRDPQRNSWHNSSESKDHDNLDIIVTPRTSSTRSSIGSRSSIRSPISKSEVDDISGAGTGRISIINTDESLTSRPLSVHRVDPPPLPPKVTIWQPDETEKLIPPYPLDDEPPPAVNKSLKPDYKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G3</accession>
    <name>A0A0B1P2G3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01003224">
        <property type="protein sequence ID" value="KHJ31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2G3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2G3"/>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="213"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="38548" checksum="178E0CB565BEE5B4" modified="2015-03-04" version="1">MKSIVFFHPDLGIGGAERLIIDAAVGLQNRGHKVVIFTSRCDPQHCFEEAKNGTLDVRVRGDAIVPVSIFSRFYIICAVLRQVSLIISIYFSSELNLLKPNIFIVDQLSAGLPWLAYLCPETKILFYCHFPDLLLAQGRNKWWKRIYRMPFDKLEEWSMKFADSIAVNSNFTKKIVCEVFPNLARNKKFEVIYPCVDVTKTINIEKNFLIDWDKKHILLSINRFERKKNIGLAIRAYSRLEKIERTGARLVLAGGYDDQLLENVAYHKELVSLANSLGLKSVTIRTTLTTIDIPEDIDILFLLSITETIKEILLKSARLLIYTPSNEHFGIVPLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V4</accession>
    <name>A0A0B1P2V4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g1795</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001666">
        <property type="protein sequence ID" value="KHJ33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2V4"/>
    <dbReference type="HOGENOM" id="CLU_003041_30_0_1"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098562">
        <property type="term" value="C:cytoplasmic side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="79"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="259"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="453" mass="51054" checksum="C8C244435EDC68C1" modified="2015-03-04" version="1">MTDVLAQNINSLKLRDAGPSTEDWKAGLVAPVKDTRPQTEDVTATKGLDFEDFGLKRELLMGIFEAGFEKPSPIQEEAIPVALTGRDILARAKNGTGKTAAFVIPALQNINPKSSKIQALILVPTRELAMQTSQVCKTLGNNLGINVMVTTGGTLLRDDIVRLSDPVHVVVGTPGRILDLARKGVADLSECPTFIMDEADKLLSPEFTPVIKQLLQFHPKNRQVLLFSATFPITVKSFSDKNMQNPYEINLMDELTLRGITQYYAFVEEREKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHARMLQNNRNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHRGLAINLINWEDRLNLYNIERDLGTEIQAIPASIDRNLYVYDSPQNIPRPVSYLQPHQKKIQENRHDGHKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P336</accession>
    <name>A0A0B1P336_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1P336"/>
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    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="639" mass="70002" checksum="C1E03A47A3B5338A" modified="2015-03-04" version="1">MAPTDLLLIDVLRSRFRFGKIIWSRDEDDDDDDDEDEDEEEDDDDDEDEEFDDDDNDDDRGRVRQSNPVPHRLQTTPQLQPSSPKAERPSKLITTPSSVPKIIQPQPIRGSSNQSLESSNTISGSAFRSPMASASVPTPGVNSAVAPALALSSATALTPASLLPSALVPLYASATSTPLPPPASSQPPKIPSPAPPPSILEDLELPTVSTSIENESGIKPTNSFPINKDEVVSNVSQLMLAPTPVSTLASSIESMREPDTFAFPSSLINPPIQVNNFPETTTCKESTPTGAPRKEINPTSSSISMTTQSVVNQPTGLSSSSQLSNAQSTNVSHQVGGLSPLAEHILVALGAIGGFIIIASLFCFIAQMRGKKIVLFQSHKNNNSRDGERGFFELDRGRNSNIVEELPRYSYSRGSLKSEMYDNKNDMAFQYPSQRNIPYEKIDNPTRLQRSSTGRTELIPPNNPIYDLPRNVEPYISQTEPYMEQQLYSNTSQPITYEMSETLNSFSSNYNNPGTLESYNSPNMYNFGQGQNQRISFASSISSGFGDGLMLQAPTVFAAEESRPPPRDLSRPPAVSKTRLSWFNGKRRDSIFSTSSIDTAPRFRSIASWVKHQSDRVEQKASTNMEVSPLRPAPGTYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P339</accession>
    <name>A0A0B1P339_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003259">
        <property type="protein sequence ID" value="KHJ31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P339"/>
    <dbReference type="STRING" id="52586.A0A0B1P339"/>
    <dbReference type="HOGENOM" id="CLU_133417_0_0_1"/>
    <dbReference type="OMA" id="GIKPWRH"/>
    <dbReference type="OrthoDB" id="5326237at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="138" mass="15870" checksum="93C22AEC255B8579" modified="2015-03-04" version="1">MSNNQSASGAGLSTSVSTYQDANQQLFDPSLDVWDEERFELAMKTLKEMHIQLRNLRTTIPRLLAPLTLQHHAPQMLLEEFKQSIKTANQEIQEFQQLMMSEESSKIFCRARKSLALNAKFNKPWSVTENPDWLTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P378</accession>
    <name>A0A0B1P378_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001850">
        <property type="protein sequence ID" value="KHJ32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P378"/>
    <dbReference type="STRING" id="52586.A0A0B1P378"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="341" mass="38568" checksum="BF9D7ED2C89885EA" modified="2015-03-04" version="1">MTPSPHDSCLLYRNKPSTIINDNTIPFGLSGLQTDDTLFLANLSFAKLEKDKMNFLCKKREKLTENHDLKFNGSLIRLEKGIINLLQKLQCDKITSAIDQNSYISQRARGAYVATMCQPEAAYDLSFAAQIRDPQTIDIERLNRRLAWQQNNTSRGLKFIPLDIGTLKLVVFTDSSFHSNPDYSSQLGYVIALVDGEGKANTIHWQSVKCKRVTKSVSASELYAISLGFDQGSALNFSINSILKLPKPIPLIICTDSRTIFDCLTRLNTVQEKRLMIDIMCLREAYEKREITEIKWIPGKSNPADALTKSKNVSQALQKLVETNWVDLESSKWVEREIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3C9</accession>
    <name>A0A0B1P3C9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g5163</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="JNVN01001830">
        <property type="protein sequence ID" value="KHJ32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3C9"/>
    <dbReference type="STRING" id="52586.A0A0B1P3C9"/>
    <dbReference type="MEROPS" id="M49.004"/>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="706" mass="79180" checksum="F1C536B8F1D7EC10" modified="2015-03-04" version="1">MSYISNFYADNPPTTVRLEIEKHFNALTDQEAAYAHHISRAAFSGTRITLRQVSPESEIIYDLIVELYKSFNGDWEKLRKKGNVNSQDLQFFLEYSAQFLGNCGNYKGFGDVKFVPRCGPEVFQNLAAAASPKAAELYNATNGGIFSHNNEGLMYLGYLDDGHVTTYYPNSKDISKSDISAVSEFLEMKGLLMENTRLRKNLDGNFDLLIASATTTIPAEGSDISKETVFELDTGSLKGRRLNLIYGDHSREMAIIANYHRKAAEVTANENQKKMQLEYAKSFETGSLQAFKNAQRFWIRDKGPTVESNIGFIETYRDPHGIRGEWEGFVAMVNLERTRAFGSLVSAAESMIPKLPWSKDFEKDQFLSPDFTSLEVLSFAGSGIPAGINIPNYDDIRQTEGFKNVSLGNVLSAKASNEKIPFIAEADLTIYQKYRDVAFEVQVGIHELLGHGTGKLLQETKPGNYNFNIESPPISPITNKPIKIYYKPGQTWGSVFGSIAASYEECRAECVAMALSCDFEILKIFGFGDGKLDMDGEPGDVLYAAYLSMARAGVASLELWDPKSKKWGQAHSQARFSILKCFLNAPDDFCKLDYKKEDLSDLTVRLDRNKILTVGRKAVEDYLQKLHVYKCTADIEAGSKLYADMTNVEPDFWGTKIRNEVLRNKQSRKIFVQANTIQDPTTGKIKLVEYEPTLEGMIKSYAERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3F2</accession>
    <name>A0A0B1P3F2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative som1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001821">
        <property type="protein sequence ID" value="KHJ32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3F2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3F2"/>
    <dbReference type="HOGENOM" id="CLU_008468_0_0_1"/>
    <dbReference type="OMA" id="NMAPHFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="834" mass="91029" checksum="05AF555402EAE0D7" modified="2015-03-04" version="1">MNIGGLNNMTGVPISGGMPMMNNLVPKGRPPMPLNNDQRSQLNTYIYEYFLRNSMYECAKALLESGQPLNVIKDSPGRRRDDNCNNEEGNDESKIDFETKRSIDLPEPNLPKECPESCFLYEWWCLFWDMFNAQRGKADGRNVIQYFTHTQAQSRSRQEQQQMMYRGLRNDLNYPQGFNNMMRNQANSGVMMNPQNELRHKVLQNNRNPTPAQLHMLQQQKQQQMQMQMQRDPSSGENQQRPQSPPSVDNAPSPSKRPRLDGASFSSQVQMQNGRGQGGGIPQQVGNIVKQSGLTNHQFQNVSGVQNVAAQRLAGYQASLGQQQQSQMPTVKALPTSGVAQNRGSPMMTQGQQENGGVANFYNHADIGQNVIRGGPGQPGAPGNHALQDYQMQLMLLEQQNKKRLQMARQEQDQMMPRPECNQVPAVSGPNGQNFPGTSPQASRSTNSPNIGDQIKRTHHMNSTGMPSPLSESQSRSSPSGNINFGLTAAPIDSSMNPQFFNKVNGMEASLVGAIPNTMRPPSSHPNNFNPMSQQAHLSLAARQHHAQQAQQQAQQQAQQQAQQQAQQQAHQQAQQQAQQQAQQQAQQHAQQQQQHPQQQAQQQNWQPGPSAQPMMTQPSQGQAGSQQTIGTPQPRSMPPPSMPPGAGSANPNGRTPQATTSPSQTPAPPTPQQSNKANPKKKSDLKDSKAKRTQKKGSAANLNAGATPSADAEATGATPTPATPMTPVHKQNFNNSQNGAVQPATNGQAPAPAGNISISQQPDPLQGGGFGLGDSTFSNYDTSLDFANPGNGNMDVLQDFDFDSFLHQDPGDTVNDFSFDPSGFLDGNEIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I4</accession>
    <name>A0A0B1P3I4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mfs multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002494">
        <property type="protein sequence ID" value="KHJ31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3I4"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OMA" id="THFSEDP"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="77"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="609" mass="67564" checksum="5C13FA288EBD26F5" modified="2015-03-04" version="1">MTNADDLVEKSAILQSVTTSSDLESARKTERVDTESNEPGSDSLDGNEAQTSKIELTEDMCYDLLGYSFSSTKKWMILSIVFLVQVSMNFNTSLYSNAIPGITEEFNVSAQTARCGAMIFLVFYAFGCELWAPWSEELGRKPILQASLFLVNIWQLPVALASNFNTVLIGRALGGLSSAGGSVTLGMIADLWETENQQYAVAFVVFSSVGGSILGPIVGGFSEKFLDWRWSIWIQLIFGIFVQALHFLMVPETRTTIMMDRIAKKKRKIGENIWGPTELIPYHQRFSFSEIMITWLRPFKMFLTEPIVLVLSLLSGFSDALIFMFIQSFSLVYRQWGFDSVSLGLAFVPIGIGYLLAWISFIPIIRRNIKERKDKPNDERAQFESRLWWLLYTAPCLPIGLIGFAWTSTGPPLHWVFSMIFSCIVGVANYAVYMATIDYMVTAYGPYSASATGGNGWARDFLAGVLTIPATPFFTNIGTNPIAYASTILAGISLLLVMAVYIIYWKGPELRHRSPFAQQLSDARAVQETPGLMDDKFPSGPLAKAVVRSQQDHRIRHALGSRTPSIVASAHNKTPMASRGASRAASPVALKRAVQKGRINSSHREHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J6</accession>
    <name>A0A0B1P3J6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001798">
        <property type="protein sequence ID" value="KHJ32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J6"/>
    <dbReference type="HOGENOM" id="CLU_000680_25_0_1"/>
    <dbReference type="OMA" id="RIMQWIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="38368" checksum="02285A419B843E28" modified="2015-03-04" version="1">MKGSILSQGTSDESRLLAQMVGCWLDFLEVVGPKGRIPDRIIKPLRSIQRKCLKLITGAYRYTSNRVLEHETATLPIETFLKQMRVQYTGLSNDQPTKQVLTSMCKKILPLGLENIDTRSRIKQNDLDTWAQRCKGVNNTTGQKKSGKIAAFQEWADSWTSQVRDQNLRSLAPANPLTWKAVNLFTDKKTNRKRMNYRGTPYELHRNLGRAQTSIATQVRSEHIGLNSYLYRRKVPGVEAPSCQCGYRSQNVKHMIMASPRWAKGRGKILRKTENRSFKAMMNNPKDMARIMQWILNEGKLEQFRLVGAIETVIKQRGEEKKLRQTRTLHWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3T0</accession>
    <name>A0A0B1P3T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002408">
        <property type="protein sequence ID" value="KHJ32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3T0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3T0"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="441" mass="48523" checksum="6ED56270F5F99CA0" modified="2015-03-04" version="1">MDTSQESQALSTDSSNQPPPILPIPPIPISPSPIASPPSPLNLQSLTKNTDGRQILKPVAPSKRLGTERTTLNNSNKINIGNAFLPKELADIVAIRQRRQRAWHARLIICTTAISSLESTLANFKDEIEVEEVAAFKAYLQLAIANFAAVDNSPIPPKIPSHSRPSKGSGHGLGKDKITAKKVASPARDSPSIATTERRLFVRLPQEHEWRKLSPAGIREVITPVIVPTVPTTIRKEQGEIEVSKSMLTEEIERVCSIRPAHVKFYGGNKPGAPHRTWMAYFTTAPRTSFRVFDESGIARKFKKQQPFEFCKRCNGYHPTKNCSRAPSCGNCGSTNHVEERCMAATKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMKTYRQAGEREYQAVLRAKTAEDLAASTQNEILDITSSEEPEAKNNTNNSQAPLVESSTCGAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V1</accession>
    <name>A0A0B1P3V1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine arginine repetitive matrix protein 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001491">
        <property type="protein sequence ID" value="KHJ33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3V1"/>
    <dbReference type="HOGENOM" id="CLU_017050_1_0_1"/>
    <dbReference type="OMA" id="QAHESRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="566" mass="64494" checksum="4175127939820504" modified="2015-03-04" version="1">MERDRDIRERDRHRDRDRDRDRERGSFREREREKDREREREGERDRGRFDRRRGETTRIGSGESYKPYGSRPRTPMRTDTFRSKRDRSPRKELPRSPSNTWHSNRARERSRRRTRSPPRRDRTPLKDNWRNRSPRRRSPLRRLSPRREDDRRVRSPLRREERRSSRSPYDSRKIKRIRTPIRRVSPPAGPRGFRPRSRSPDRQEIQKAPPHVNRRRRSLTPLARDSEKPPLKSTGTPRRLSPPTHSDRVNHPQGPSKQRSPLPKVSPGFSHRERDSIKQPNREHHSIRSSAQKSPPKGPASLRTSTGSVGSRNFTAPTPTSISSRLTTVTPRPKIESPVPLAPPVGPRGYVPRGGSSNRGGRGSFMGDRAGKSDTSSWSTSTPDHKPSGPESIRNSLKLPKSGTKLTIDTPKTPSPSQPSNPPVTSAPSGPSSGVPTGPRAGISSRSNLSYQHSSSMYSRSIKLVSNHCGNRPQITLANTVSIIPSGRIDPTANGIAPEIVAKLKRKEEEEEVLRAELNSKEEKLRKSLKHWDKLSRDSRAMGLRSDLSEKHVRTLAGEGDRRDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V6</accession>
    <name>A0A0B1P3V6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl-n-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001697">
        <property type="protein sequence ID" value="KHJ32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V6"/>
    <dbReference type="HOGENOM" id="CLU_477509_0_0_1"/>
    <dbReference type="OMA" id="AHETHCD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="414"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="571" mass="64980" checksum="C2BA3885215534D0" modified="2015-03-04" version="1">MSLQKLTQSEYDFSSHGAPSNGTTHTSKNDSSLCTQNQAIICSSPVLSAQSSSDISISATLKPRPIFDAKAFAPKTKQKSRASSRNKKSQWPSFKRLISNHESQNIPISDSPKPAELKTSLLRNEWDGMDDILPIEESHIRESEPDMGINLSVKAEDEASLKTAHETHCDWPDVAYEVGNKENIRALQGTDPILEHFDFAGARMPPPCDWELGRSRFDNSFMNSYINEWRQVESFRPIPTGFEKNEKWLSGEFQVCDHELLSIPQPRPSIPNPSTTDALEVKRITQTAHNIVIHELEKLELQSTCQSNSEKENRFISTEIFHKTSENSPFSPKIDLFLRPVIIEDSEKIALIYNEQIDKGNITEDQQPISINDAKILIESKKKDNLPFIVAVAGRAPLPKKNMQDDKAQYDKLYVNKNVIGFAFNERFNYGFSGLSKGRSRFTTTIQLFVAQEYQGKGVGRNLLDRLIHMLSTAYGYKKACEFINPNSDKVYECEGSGKWHQIQFHVPVLQQDDPDFPRIKDFLFSKFLIKEVCRMKSTGRTNFRNGPAKWLDTVIFQYETSQEGDFDPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P484</accession>
    <name>A0A0B1P484_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001627">
        <property type="protein sequence ID" value="KHJ33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P484"/>
    <dbReference type="STRING" id="52586.A0A0B1P484"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_0_1"/>
    <dbReference type="OMA" id="PREDEQM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="304" mass="34295" checksum="23484E98F57094C6" modified="2015-03-04" version="1">MGKLLEKLVANRISKAAEDFNLLPEEQMGARPKRCTISAVELLTEQIHTIWGKDKKKVASLLSLDISGAFDNVSHKRLIHNLREKGIPRWICKFVESFLEERTTSIVLGSFKGKQIPTSTGIPQGSSLSPILFLFFVSTLLPLLQTPSTAAVGFVDDTNILTWSSSTEENCRKLEEKHGVCEEWARKHGVRFAPEKYQLMHFTRARKRHNLEAKVSIQGHLTSPQPSLRVLGVYLDPKLNWGAHIKRVEQKSHTHIQVMNRLVQSTWGATFKRSKLLYSMLVRPALTYGPSIWALDMGRGQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4F0</accession>
    <name>A0A0B1P4F0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01001352">
        <property type="protein sequence ID" value="KHJ33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4F0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4F0"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OMA" id="KIGGYPP"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="36297" checksum="3F2E48987852CE72" modified="2015-03-04" version="1">MPGLPASVDLDKCIENLYKKRLLADSVIEAICAKTKELLMQESNVVHVNAPVTVVGDIHGQFYDLVEIFKIGGFCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPQRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDYLTLSVVINDQIFCVHGGLSPSIHSIDQVKVIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVKKFLTVNNMSHILRAHQLCQEGYQILYDDQLSTVWSAPNYCYRCGNLASVLEVSDSGERFFNVFAAAPENDLVKVDVQNSGEKSTSRTNLPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4L6</accession>
    <name>A0A0B1P4L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative udp-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001307">
        <property type="protein sequence ID" value="KHJ33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4L6"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="OMA" id="CVILRYF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080479" evidence="4">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="460" mass="51491" checksum="A79E8A84EF5F32FB" modified="2015-03-04" version="1">MPWLIVLQTALLNMVFFWRNLEKLLKMNSSDSEVSSPQASNCNPNSSPISEVYLSPIDQDDSEKNLKPVYFPEENFIAVVGGLGYIGSHTCLELLRAGYNVLIIDNMSNSFDTTHDQILYLARQYHKARGQKVPQLSFYEADYRDEAKIREILSDYTSPILKTPDMTQAPNSRIVGVIHFAAYKSVVESIENPLKYYDNNVSGLIKFCIILKEFNIKTFIFSSSATVYGSKANSEVLLREEHCVHQTESYYDQFGIFKTNEPGCSGLTNPYGRSKWMSEAILSDIATADSDWAITALRYFNPIGCDGSGLLGEDPRGIPTNLMPVVMRVISGQIPGINIFGADYPNTHDGTAVRDYIHVTDLARGHISAFESAVERKGFRTYNLGSGIGYSVRDIIQAVEKVFCCKIPTQIAPRRKGDVEMSVALPKRAGDELKWKTEKSLNDACKDLMSFIKMRKGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4T5</accession>
    <name>A0A0B1P4T5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nuclear pore complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002453">
        <property type="protein sequence ID" value="KHJ31951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4T5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4T5"/>
    <dbReference type="HOGENOM" id="CLU_044363_0_0_1"/>
    <dbReference type="OMA" id="QYATTFD"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="26869" checksum="AC5A996C1D037632" modified="2015-03-04" version="1">MITPPLPSTPVNRIISSSPPAGTWQHPRLDEIVSRQNACSFDKRNIKSIIYNTGVVFAIIFAARQVTKVFPFLLHDSTSLKQYIRFLYYFIQAILVYNIIIAFLPLFRQTDDLADIPLTPAQRKLLGLSPLSAAHTPGSKFNTPPRYARTSTPLSGSPIGLLSPGKENASFGNFTGSPLSVLEKFGGINTRSSFGPKSLSPNFKGIYETPGTPTPCLSKEGVTVSSKWLYEKGRRSSVNSRIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P507</accession>
    <name>A0A0B1P507_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P507"/>
    <dbReference type="STRING" id="52586.A0A0B1P507"/>
    <dbReference type="HOGENOM" id="CLU_113403_0_0_1"/>
    <dbReference type="OMA" id="WWGLPED"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="161" mass="19019" checksum="12C7BD497F304F9F" modified="2015-03-04" version="1">MASNSDEDKVISRLPMPSRNPLPLSSAQETQVRDLYYSRVRGYCAAEIKSFADCALGRTFTAPFKCRKENQLMNKCMLSYATPEEQDAAREEWFALRLQRQIEREKKEERRKEQEKFHREWWGLPPNERESKEGLEIIKKAERVGGFPRRDEGQPSKDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P541</accession>
    <name>A0A0B1P541_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001464">
        <property type="protein sequence ID" value="KHJ33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P541"/>
    <dbReference type="STRING" id="52586.A0A0B1P541"/>
    <dbReference type="HOGENOM" id="CLU_022194_0_0_1"/>
    <dbReference type="OMA" id="THPKMEG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="497"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="698" mass="76684" checksum="888A388B02C675A8" modified="2015-03-04" version="1">MDVSCRKLKAEGYTALNLLLKGPANASLTIELNTSPSCSTTRHSSYYTNLTVLSHEIQSYTVPLRLFRGANLNALRSVKLFDLTPGQWEIGENQFVCAYSLEKKPTTHIQSKSDVNAVSQALIARETAACTSFLLDDFASQSRLTFLFYNAALLPSSDDGTMKPVTGRVDTQTSVIVANNHVTLTPANVNSYWFTQIGCLKATNQWGGIGLPIKAEPGMVFRVELSSDTSCSNTNHKNVALTSKDLGWTFDGSEKFYQIPFSKFPGLDTDHLVSLLFSGLDRPITFGPIALYCGNTGTAYVPPPNLDPAEPNDTVPPTSGTSDIVIDTFSNNDNNNLGFYHGGDDLNAFQIADSKLTINTKGNADFAWYTQIANGCFDLTPLQDGYLHIIYSGSSAFTISLQQHNPTCNDKIQPIPFTWDSVEASRYSNSMNTEIFVPLTHFAIDRSKSIGFALRGFYSNNPTMISKIEIVKNVPSGFLIPSKLPTSPLIFSCSRPNSFAFAIDDGDPKFAQRVVSTISEAGIKVTFFTVGAALRDTSTNLTGVYKGMLDAGHQVAYHSFTHPPMEGLPSLAAIDWEINQDMQAVQEKLGIASKYFRPPFGTEGARVRQRLQSLIPGSKFVMWSVDVQDYLWATSPTPENQIKNFQSDVDKGGNLVVMHYLYDTTVEYLPRFINIAKATGKQLMRVDQCLEDPSAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P560</accession>
    <name>A0A0B1P560_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002359">
        <property type="protein sequence ID" value="KHJ32086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P560"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="37184" checksum="61862986F2F512C4" modified="2015-03-04" version="1">MTASMDISQESQAPSTESSNQPPPIPPIPPKPNTPSPFASPSPPLNLQPPTNTTSGRQILKPVAPSKCPVTERPSLNNSNQFNIRNAFLPRELAEIVATRQRRERGWHARLMICTTTMSNKESTLVNFKDDVEKDEVEAFKAYLRLAIANFAAVDTSPTPSKVPTHSRPTKFSNYGLGKDKNVLKDVAIATPQIMKSVASIGGNTQEVHKLLKNPKINQNTWATIARNGQKKARVILSNKKQVASVSQSMIIKEKSQTKFIDKRQFVRISKEHELLKLSSAGLREVIVKKLSISASLIGKIKPVHSGFALGPCNNEAHEAILTAGNGLFMTGAKLEQATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F6</accession>
    <name>A0A0B1P5F6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5F6"/>
    <dbReference type="HOGENOM" id="CLU_2265712_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="103" mass="12539" checksum="3F49FF9D5B2B7616" modified="2015-03-04" version="1">MFGPEAWEYRAREEYYGFQMAKNDTYRDFRIKFRRLAIEGKIPRQAWFHDVCAKISPALRRDIKGEKFRMNENYTRLDEYLQYLDRENAAIRADPRLHTGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5I3</accession>
    <name>A0A0B1P5I3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ubiquitin-40s ribosomal protein s31 fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001135">
        <property type="protein sequence ID" value="KHJ33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5I3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5I3"/>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="155" mass="17711" checksum="D2F0EA2471E40BC8" modified="2015-03-04" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPAEECGASVFMAAMQDRQYCGLCHLTYIYSDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X2</accession>
    <name>A0A0B1P5X2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002204">
        <property type="protein sequence ID" value="KHJ32286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X2"/>
    <dbReference type="HOGENOM" id="CLU_1670681_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="18361" checksum="9AD9F385E6B722E9" modified="2015-03-04" version="1">MFDDISKRKDDQLMSHNSFENESMPNANQYSQTSNNTIEPLPQVDTFSQSLTGERKNSLSFNFFSTPSILTTSSTPLLAETQENNYQTNHRHNAPLINSKEPQILFQLPIEQRERRLSNQSEPFQQHVHYILPQLSEDDDQHRQSHDEKENASQLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P685</accession>
    <name>A0A0B1P685_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002075">
        <property type="protein sequence ID" value="KHJ32456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P685"/>
    <dbReference type="STRING" id="52586.A0A0B1P685"/>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="OMA" id="RCFIVRH"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="26194" checksum="0EFD709E8018DFCD" modified="2015-03-04" version="1">MSSIVKRAPRVFLIRHGETEWSQLGKHTGRTDIELTANGKAQVIRSGKILIGSGKIIDPQRVVKIFVSPRIRAQQTYQLLFPSTDHTYVKETSENIREWEYGRYEGLLTSEIKSQRKDRGLDINSSWNIWVDGCEDGESPTEVTDRLDKFIIQIKEIQKLQMHEENSADVVVIAHGHILRAFAKRWVGFELSMNLRMILEPGAIGVLSYDHNNIHEPAILLGVNFGSEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6E0</accession>
    <name>A0A0B1P6E0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative short chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001729">
        <property type="protein sequence ID" value="KHJ32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6E0"/>
    <dbReference type="STRING" id="52586.A0A0B1P6E0"/>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="OMA" id="NWYAVLP"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="37677" checksum="2F50AE8314A0EFD5" modified="2015-03-04" version="1">MNHQLPPQPLSWAKFFSIDLILKVLNTTFFHPFVAWMIPLCMRAQAMPWSHTAIQLSIGYASLLTLLCFCQILNLQIAYSKPRKVDLSEEIIVITGGAGGLGLLMAEVYGMRGATVVVLDIRDLEAGEVRGVTAYKCDVSDKEQVAKIALEIERDFGTPTILINNAAVVNGKSLLDLSIEEIENCVRVNLLSQFYTLKTFLPGMIRAGSGTIVTISSVLSSLGAASLSDYTATKAGITAMHKSLTAELKSTPNIKTVLVSPGQIGSSLFSSVKTPNSFFGPILESVDVVKEIIATIDAGSSAHLAMPLYARWIDWMNVMPVGVQAILRRLSGIDNAMSTFHKKDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P8</accession>
    <name>A0A0B1P6P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative vacuolar iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000920">
        <property type="protein sequence ID" value="KHJ34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6P8"/>
    <dbReference type="HOGENOM" id="CLU_038957_0_0_1"/>
    <dbReference type="OMA" id="MNFHHTL"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="35611" checksum="30A96ABD8493A449" modified="2015-03-04" version="1">MSLVGLINLLFHRTIVSEAKSQRTTRIPNASTTSAYKTSESRQWERDIQVPLLTSPTDSISQPTSDQFRDIESLKYVDLASSTEKQSKGFRIDARLISDATIGLSDGLTVPFALTAGLSAIGNTDVVIYGGLAELTAGAISMGLGGYLAATSEAASYRAQREKTENSLAANSEFFIQDIAEIFRPYNIPKQTINDLIKHLTDSPRVVDFVMQFKHCEEEPPASRAFVSAITIALGYFMGGMLPLIPYFFVDRVNSALLWSIGLMIVALFAFGYVKTGIIEGWRGDKNVRSCLYRGLQMVVVGGAAAAAAMGFVKLFQNSHSRDPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A4</accession>
    <name>A0A0B1P7A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A4"/>
    <dbReference type="HOGENOM" id="CLU_036943_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="23265" checksum="FE9A8D5AF08D3CD4" modified="2015-03-04" version="1">MFMAPALGSKRALPPAHPDAEKRFSKPKPKPVLADAKTPSPSNNSSSKGQGSAASLMGAIKELLDLTNYYLENLEIQYSGIGSDLLALIADGVSRAMRGERVYRDLSKIKNTHKHPVPEKWAGKAKDQSAGTKVFNIKRQTLKATLPHGQSKEDRRVMIRLKPDREARKNGSFEHRQTIQKLVPESSLVSDAWIVPSVIATLAPIPAKAAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7I8</accession>
    <name>A0A0B1P7I8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative meiosis-specific topoisomerase spo11 meiotic recombination protein spo11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001928">
        <property type="protein sequence ID" value="KHJ32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7I8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7I8"/>
    <dbReference type="HOGENOM" id="CLU_037229_3_1_1"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="180" mass="20976" checksum="CB65E72A4E4B8B55" modified="2015-03-04" version="1">MRAFFRFKLLTLSKKATFRTLISSLYWKYSSAGKGILITAKGYPDMQTRQFLRFISLRYPKLPIYALMDFDPDGIAIMATYKFGSIKSSYQKNYTVPQIEWIGIKSNVILHFLETSQGLQILSARDRRLAIKMLERVRVMEWKEELQIMLMLNLKAEIQILGNSNSLCQWLDFNLLNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7J1</accession>
    <name>A0A0B1P7J1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative long-chain-fatty-acid-ligase 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000986">
        <property type="protein sequence ID" value="KHJ34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7J1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7J1"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="OMA" id="KIFQWAA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="697" mass="77800" checksum="4E85D97839111845" modified="2015-03-04" version="1">MFIKDLQPRIAKDRIPPFSVEIPNYKAVEGETIPRRNPRCIDKLIDRPDEGIETMFDVLKRAAEKFGNAKALGTRRLIKTHHEVKKIKKIEDGIEKEVDKKWTYFEMSGYEYISFYDFEQMALELGAGFRKIGLQKDDRVHIFAATSANWLGTAHGAISQSMPIVTTYDTLGEEGLSHSLKATKAKAIFLDPHLLPILINPLKEVDVDIRYVIWNSQNEVEQKNIDKLKQAREDILIISLEELRQLGKENPVAPVRPSPEDLCCIMYTSGSTGPPKGVPIKHKAVVASIAGVSFIVDPYVTEGDKVLTYLPLAHILEFVFENAALYWGTTLGYGNPKTLSDISMRNCHGDIRELKPNILIGVPAVWENIKKGILNKINASNLLVKSLFYTSLWLKNIILQNDLPGLKILDAIVFNKIRQATGGNLRLCLNGGGPISKDTQWFISMALTPLINGYGLTETTAMGAVMDPREWNVDSLGSLPGSIEIKLVDYSEAGYFATNRPNPQGEIWIRGTPVMEGYYLDEEETKKTITPDGWFKTGDIGEWVENGHLKIIDRKKNLVKTLNGEYIALEKLESIYRAANVVANICVYADPNRTKPVAIIVPGEPALKKLASSNNVDGVGVEDLSRNKEVQDFVLKQLQKVGRDGGLKGIEIIEGIVIADEEWTPSNGLTTSAQKLNRRAILEKYKKEIEAAYSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R6</accession>
    <name>A0A0B1P7R6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01001478">
        <property type="protein sequence ID" value="KHJ33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R6"/>
    <dbReference type="SMR" id="A0A0B1P7R6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7R6"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="331" mass="36352" checksum="FAD69AAE952DA089" modified="2015-03-04" version="1">MDQSSPIPSYVRTAFAVIGILFIGSKVISYIRLLLSLFIFKGNNLRKYGPKGTYAVVTGASDGLGKEYAIQLAQKGFSLILVSRTASKLEALSTEITQKFVGSGIQVKTLAMDFSHNRQEDYDKFQALVDEHDVGILVNNVGQSHSIPVPFILTPKEEVRDIIAINVIATLKVTQIVAPGMVQRKRGLILTMGSFGGLLPTPLLATYSGSKAFLQQWSTALGGELKSSNVDVELVISYLVTTAMSKIRKTSLLIPNPRSFVRSVLSKIGRSGGAQNMAYTSTPFWGHGIMQWWLENATGLGSTFVVEKNRQMHESIRKRALKKAEREAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7V4</accession>
    <name>A0A0B1P7V4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001432">
        <property type="protein sequence ID" value="KHJ33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7V4"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="253" mass="27836" checksum="A432E4BCFD1ACA29" modified="2015-03-04" version="1">MAPLTRDKKRDVPKTLDPKSRVQKSTNKTERTQPLAEVLNRSVEKSSTVAKQTAAAQDTQVVTPFESQATVEDTREANTPHKYDTPDQNSKLMTMARGLLNLVGPYLEEIDLECPESGTGFLALISDVVSRVIRGEKIYTNIDIILRNASTTPSNNRNTWAARAARGNNLSLNNSVWGPPAKPSNPPRGQSFEDRRILIRLGHDHEARKAELFLLRQQIQSLIPDPSLVSDAWQAPSGIAILAPTPAKAATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7V9</accession>
    <name>A0A0B1P7V9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001427">
        <property type="protein sequence ID" value="KHJ33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7V9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7V9"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="FCDARED"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="294" mass="32331" checksum="BE6C9782C5F450E0" modified="2015-03-04" version="1">MNHIELKMRTLVNRKFSPLFKYKNIVRSFSSQSSRAYDFIQIKEPHPGVGQITLNRPSALNALSTPMMIEIGEALQRFDRNPIVAAIILTGSQKSFAAGADIKEMSNLSFSEAYTNSFIELWSAFTTSVKKPVIAAVSGHALGGGCELALMCDIIYCTESAIFGQPEIKLGTIPGAGGSQRLTRAIGKSRAMELILTGETFSGREAVNMGVAARSFGSWDDLIEGTLKLAEKIAKHSRLAVMAAKEVVNKSQDLPLREGIEYERRLFHSLFGSADQKIGMKAFVEKKKPEWTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P874</accession>
    <name>A0A0B1P874_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000632">
        <property type="protein sequence ID" value="KHJ34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P874"/>
    <dbReference type="STRING" id="52586.A0A0B1P874"/>
    <dbReference type="MEROPS" id="M67.A01"/>
    <dbReference type="HOGENOM" id="CLU_053034_0_2_1"/>
    <dbReference type="OMA" id="VKMKLFQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="38317" checksum="DE298A4684E6BE05" modified="2015-03-04" version="1">METAFKNWELENNVKLVDPHRDALYAYDTEEQKAISNANPWKTDPSYFKNVRISAVALLKMVMHARSGNSIEIMGLMQGKIEGDTFIVTDAFRLPVEGTETRVNAQDEANEYMVRYLQACREQGKLENAVGWYHSHPGYGCWLSGIDVSTQHIQQSFSDPFLAVVIDPDRTISAGKVEIGAFRTYPENYKAAESSTNDGYQTIPLSKIEDFGAHSSRYYSLQISHYKSSLDTYLLELLWNKYWVQTLSQSPLFTNRAYNCKQMLDLSTKINVLSSSLPRANRIPGQMQLYNNKYIDLQLDKIVKDGSKLSSEGVMGLMAGEVKVNLFKGLRETAEDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8F3</accession>
    <name>A0A0B1P8F3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000601">
        <property type="protein sequence ID" value="KHJ34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8F3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8F3"/>
    <dbReference type="HOGENOM" id="CLU_062456_2_0_1"/>
    <dbReference type="OMA" id="PSYMNES"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="18697" checksum="3841B3F528A18D9E" modified="2015-03-04" version="1">MVGQHLLVCSIGNPAPYENTLHSAGHIVLSALARVLSYKFEKARGQSGSQVSVGQDYILWKSGSLMNVSGTAVAQAWKFYGGKQLVVLHDELELPLGNFRVKSGKSSAKGHNGLKSILIKDYTRIGIGIGRPISRDSDLVAAYVLRKIKGYERATLEACASKVLEELQKISLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8L2</accession>
    <name>A0A0B1P8L2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001544">
        <property type="protein sequence ID" value="KHJ33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8L2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8L2"/>
    <dbReference type="HOGENOM" id="CLU_045001_0_0_1"/>
    <dbReference type="OMA" id="MGSQVQM"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="34506" checksum="45B84F09A3C749D2" modified="2015-03-04" version="1">MEYAQYQTPQQTQHGHSQGHLQATYSNSAQHQGSNPSMTSSPQPILPQPDQQSHPMHQQLNYPTPYGVSHHQLQYGMTPQAAAIAATAAATGQGYQYNIQGTGIAQSSPRMSGINVKQELSQGSPKQLNNQMAHVQSQGRRVAQMSSPAVQAPQPIMNHGPPRSMIPPMAGSHHLQHQPELGELASDESPLYVNAKQFHRILKRRVARQKLEENLRATSKLRKPYLHESRHNHAMRRPRGPGGRFLTADEVAEIERAKNEGSGEKSDLLNHDPSLTNSIVGTKRGAESEVLGAIKKIKHIESQSSNKNGIADDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8X7</accession>
    <name>A0A0B1P8X7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001464">
        <property type="protein sequence ID" value="KHJ33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8X7"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="226" mass="25137" checksum="1F8BD4AB7F567843" modified="2015-03-04" version="1">MKEKEIDRNMKRRVTFATPRIIPSQVPSRGSYKNAELLKTSQSGINSCLGYSRTQRSEKGKDKSKHYSTSGAMDKTSHRSINKDKSENTTSSTKAISDKKLLLRLPPEHEWRKLSPASVRRVMVKKLYISSSLVGKIKPVHSSFALSPSNSEAREEMLKAGLGLLLSGVKLEPATIWVSVLVLTVPAFIQIEQGKVEVSKSMLSDEIKRVCSVRPANIKLFGQNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P916</accession>
    <name>A0A0B1P916_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative upf0648 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001593">
        <property type="protein sequence ID" value="KHJ33164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P916"/>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="OMA" id="IQLKWNN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1250"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1656"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1994"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2528"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2594"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2766"/>
            <end position="2822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1994"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2011"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2532"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2604"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2766"/>
            <end position="2815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2893" mass="332193" checksum="AFD06DAAC53420C8" modified="2015-03-04" version="1">MAFLSSTFILGVIVLAYISSFVLFATLRILTGISIQRIGYFSLRRISYSPKAGVKVEIRCLGFHIHRPTFAQPTWLSIVLTGLAITVDLKMTEREKNQDKRQRRKHHGYASQLQDRLDEKCSETLRSKTWQQLTVIKDRLKRLHRNIKWIRMVDLVVTNSTISLTNVGTIQIGNFTMVVDTRARMMGQGRTHLPPEGLEKQKQPAEWVITARSILFTAEGENPVEILDHATLNIQGLLSRELDGLRDTSISLKLGRVHIPYDDLNKCIDRYQLFYNSLQKNKLLQTMDVFDDQVLEKIDKNNFRKENMGQKHFESTELISSVLRGIKEIQFVASYVGFMKRLSLIQSNGLPICLNISMKEVGIDLNRLDQKSPAHRMYFSPKDIAHQALVAALSIAIGIDGDVKTERLAYIPMATTTIRTTFISKIVESTGRNSADERNANMLFANVVVTSPSVDLDPKQLALVLSISKIRPRSMDNFIEKRKYCLISRILPKANVKFSMHEPVIRITLPSVEKNVQKDGLDLIISSVSSVSLDIESSHSSLGDLHYGLVSTFRLQSLALYYQTFSGAHYELLDIESLELKTQINAKSELYVVVTGVLKTFSVHMVRPEINDGIHQILRQISFDVESENETPKRNAFKLNFVRALPSWLVNFSLQIDDFSIEIAGIDEEISGQTRGVALQLESWIAEYHVSEIENTEVKPRRRLSRSLNSDSDIKCKRQKTKSFKSQNSTHGRKLSIQMKSLEVFIVESLQKWEQDPLIAMPKLEFTFSTTSDKHGPVFDIFLYIKHLLIDCSLYRYYACLVACMVLKRAFMQTNTDLHEDEKSQSIKNLEINDGLSPIKCQVSNTQNSQEFSKFVREQISIDFGAALLQIRAQMPSDPPIMLQIYNMQAGKCRWDSPFLNAKFLRLGSGAPRIRQVWAKIISIKNFRVDYRESQFTGEDGVIKAEKYIDINAEATRIAIPHQLVVHQVVDNLVNTLKSVEQLHHRLLHSEKSVTENKCSVEPKQFPKVLIRVKALLFELEDGLFEWKLGVIYRTGILEQAQRLARKAVFNVKARKVKEETQKNLAKLTGKFTHTQNRDKFPDLDRPSSRNEENSSILSQDSQPLEYFQARYNPDGACKITSSAKITSGEAYEKLLEFDSQSWKRRIDQAFFRTKAKMRELREAFWGADELPEDVKSDEETLQVPQRPALMEVYISNLYIKIEKPTFPLAELPNFINRVGKGMPHDMKYALLIPMHIQIDMGEARASLRDYPLPFIHVPSVKPNQSSCLPAWSLKANFVIGEEFCNCESSRNVEIEIVPPRDNNKGTPSQGRFAINISRTISAVKSYSDINVDINTANPTRITWGSSFQPAIQDMMMTIENFTKPQIDPSDRIGFWDKIRYSFHSRVNLAWKNDGDVHLLLKGSRNPYEISGNGAGFLMCWRNNVRCNIRQCDDPRKLMNVQSGQYILAVPDFRLQAQKLSDDNCSIENESIFDSFEDGTTFKKIIMKLSGNVQWLAGLMFERNLAEPGQRSFNFKPHYEIVLKRPDCAKSNDNLSYDAFRDFRSNHIHLSIAVKAPMDVNFPFSNARKLESYNTVHLSPKFFSHFYAWWSLFGGATSLPIRQGSLWPGIDKSSKKFARHLATIKYNILLAPIFISHVYKHNDTTDFDINADSVTGLKIKLENFMLDAHQRKEELEAYEKGHKTQSKTSGMKMHQAQLDLISVDIRAITAKIPETSSDKLDLAICSAQIFQTDEKNSGQSHFDSPGNDLSWIDKDDLVELDWIRPSNKSLETKILPLVYAPRLTYFRQTDQENLQENGCNQNPFGSELTHFCTMTKDDNPLWEQYELTKRRKDQLQKQMKSHILSLRNAEIRASQDIQNEKYRADLEQLKRQYQLFRDKNQFLESMLKSFERCVPINDHLNLLEKDLFSKSYGEQSLENIGTSSSEEFNTELLAKSRSDFNNRFVIHNMQLKWNNLLRNIILRYIHHASQRQGIVYYLSRRAVKFILDIVQEQKRPKESKREKEDKKIEPKTNSSTFGHGIDSSCQNASHYFNEILSEAKKFVHTLEKDFNDSDAHNEAMENSDISKDFLPMNSYHLHLIAPQIQLQSEKNPMAIVLVTAKGMEAKVIEIMDRDRVLDNISGLVQRKFSVEMDSIQFFVTHQKWFSSQILSMYSGNHYGAPADSAWPPWVPMEVMFDFKVDPFGFKRVVQKTSASLRYDKYNTLRLKYNDEVTSETISENKLNPKGINRMDRVWVEFPKVHAICNSAQYYAMYIIVMDLLMYSEPQEKTRNELLEKIILASDFSDLRGVPEMIMTLQERIRQLEEIRTNFFNLNSLDEKDWEDKLLLDRDINSCENELFFMMKAITTSQRKYDTSKTSGLLRWNIASEQIKWHLMRDNAEPLLEFQLQRAEYDRTDNYDGSHNNLIQISKITGLNLLPDAIYPEILAPYLDINGKAFNGDSNQKMLRVYWYMLEAIAGIPVMDHFDVKLFPMKIQLERDIGKKLFDYIFPGSDNKYQSSFMVEKMELIKDDLEEDGLNLKKSINLPKEQFDEQSNTNSSFQTETVERRPESMLNFEQGQNIASSKKNSKNLGIQSLDRQHFRLFQSHQMITPGLRISSKKSSKTSDGNNSPIRRTESFQTQHASIYDSKSKRFALSRHNSKLKIEQSSDDLTKMMGRASSYMTFANVKINSVVLCLSYKGKSERNLEDIHNLVFRLPDLEYRNKTWSNLDLALAFKRDVIKSLISHTGAIVANKFKHRPSAAQQNRIRELASNSLILPSSSQEAPFDYSDAASSPSASVNKRTSTNERSNNSERSVSSSQNSIQRSHSYSSNISNMKNLPSGLVMTSMGDEVIKDDTKVLEKKTKPKSRVLGLLVKRNDCSSPENKLKKIESGSEKRRTRHSLKIILGSGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P992</accession>
    <name>A0A0B1P992_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative simnilar to protein from sclerotinia sclerotiorum</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001556">
        <property type="protein sequence ID" value="KHJ33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P992"/>
    <dbReference type="HOGENOM" id="CLU_1994306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="14552" checksum="445DB02FEF28E3C0" modified="2015-03-04" version="1">MQRRILQLEMSSKQADNFAADIPILRNESVPNLRVNQSNTDNILSQRNVFSDNNIRRAVVPNLSSKLNDVKEVSPNLWKLKIIDKLEMYANNFLSDRHQKNYLIDQTEGIARKYLEPLILNKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9L3</accession>
    <name>A0A0B1P9L3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5733</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9L3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9L3"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="KEIRILX"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20880" checksum="5F9E023EDEE193D4" modified="2015-03-04" version="1">MGLTISKLFDRIWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLKQRDWYIQSTCATSGDGLYEGLEWLAQTLRKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Y6</accession>
    <name>A0A0B1P9Y6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane alpha-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001022">
        <property type="protein sequence ID" value="KHJ34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Y6"/>
    <dbReference type="HOGENOM" id="CLU_042190_0_0_1"/>
    <dbReference type="OMA" id="FDEHNPE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="501" mass="52783" checksum="37D40960F29080BE" modified="2015-03-04" version="1">MSPCIAASEIISESSIPLKLCRRNYTNDTNMASYRPSIEPINSQYVMSNATSTNAHVAPPEVAPTSSSMTAASETLAPTTTPSPNPAQPATTSSTVPLTTVPNTSPNTSPPPASPTPDQPPSNTQGPNPPQSPSPNPSPNPAPNPSPNPSPKPPVSPTDQPTQPTDPPPPKSTPGQHSDTTITKTQVTPENTAAPSFVTVTLSPTSPGGSSIVTIIQTSTHAGNPGSKSASSQSSSPTSTPELQRDPSDGSNNGLSGGTKIAVAVIIPLLAVTLFVLAALFMFRRRKQRKHAEELRRKEVEEYGYNPNQDPTFPVIESLDGNNPQEMREENAGYRGWGATAPVPGRINSNKMSPNSNPATVAGIGIAYSEGESPTHGTISDTKSDNPLISELNGSNNERHQLGNMGPTVKGNDNGNINRGNSNASSSYSAANRSDESGEINGRYYGQQYSPENYSGLQNNATTRVEMPAQPIIRDVQARRNTRIESPSHFPPQSTGISQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA80</accession>
    <name>A0A0B1PA80_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001206">
        <property type="protein sequence ID" value="KHJ33831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA80"/>
    <dbReference type="STRING" id="52586.A0A0B1PA80"/>
    <dbReference type="HOGENOM" id="CLU_052538_0_0_1"/>
    <dbReference type="OMA" id="WWIAQRI"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="291" mass="32773" checksum="24218D777EC5C76E" modified="2015-03-04" version="1">METFITVQRKWILPSVDRMSYEIIVALVIVLTIPFLLHYIFYRSSGNKTVPSFILLGPCGSGKTSLLTLLKLGQSSKTHTSQTSSTVELVLPNDKVSGSDRYRSINDPSHHLNRKFLLTDTPGHGKLRPIAQKNLSTLQNIKGIIFVVDASRLKNGDDYLRSTAEYLYEVLLLLKKKAEESNYLKVTSVLIAANKMDLFTALPKELIQNNLESEISKLRISKIYGLQDSGAAEEIGLDDEKDEWLGENGSEKFQFSHLRESINLSIEILGGNVNGKNPHVEEWWAWIARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC2</accession>
    <name>A0A0B1PAC2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">EV44_g2968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAC2"/>
    <dbReference type="HOGENOM" id="CLU_036502_1_0_1"/>
    <dbReference type="OMA" id="VFRAWSG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="47094" checksum="C043298B907782F8" modified="2015-03-04" version="1">MAFNFNWSPLTADADFYKRAQEMLTTALNKSPKPPIIVDDIIVNELNLGTVPPELEILEIGDLAEDRFRGIFKMCYSGDAFLTLKTKVQANPMKTYLTSTSSFTSPRPLAAASSLMIPLQITLSQIKLSAFIILVFSRQKGLTLVFRNDPLESLKVSSTFDSIPFVRDYLQKEIEIQLRTLMMDELPAIIHRLSLRLWCTDYASKEFLDTKEKIAQKEPTTDLFASSLQDAVDSRGNFLDANEISLLLDGGSEIHLLFSQKNLLRLSTLRDSHQTLSLFTPSISDAVFRAWASASDRADTAGTITPMSPDLKRSHSTTGSINTTYKSNQKLDDTLSTSSLSSFPSTVSLPSTTGLSLGSTRNTRSHLRKKKTRIINLRKSAIIKENSQDNPGNQDKFIQSTEDQLKMNVIEPEDCWNMTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAL9</accession>
    <name>A0A0B1PAL9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000915">
        <property type="protein sequence ID" value="KHJ34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAL9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAL9"/>
    <dbReference type="HOGENOM" id="CLU_045637_0_2_1"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="318" mass="35588" checksum="CB78FAFB9A1E1869" modified="2015-03-04" version="1">MFNQALTSINIDCLPKTAEGKARNLYEVDSKTLLFVATDRISAYDAIMKNGIPEKGILLTLLSAHWFKILPTYIPGLQTHFISLSLPSVVDSMPNLKANLLNRAMLVKRLKVFPLEAIVRGYITGSAWKEYQRSGTVHGLLVAEGLQESEAFPQGPIYTPSTKAALGDHDENISPAQAVEIIGDKYAHRIEALALQIYKVAQNYAAERGIIIADTKFEFGLDEDTDEVVLVDEVLTPDSSRFWSMKDYKIGRGQPSYDKQFLRDWLTRNNLQGLESISMPDEIVNETGKKYKEAFEKLTGQTFQSKNTSESGSQMNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAR4</accession>
    <name>A0A0B1PAR4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000436">
        <property type="protein sequence ID" value="KHJ35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAR4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAR4"/>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="122"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="429"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="531"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="624" mass="71899" checksum="14951C92F3910D57" modified="2015-03-04" version="1">MHTDELIQIPKALESADFKSIELSLLSLDKHLVLRTYLEGYSLSEIDSKIWISIRSNKVAVAHVKRNILINLGRWYKYVEQTHPEIQGDVIAQVEKEKAKRAAASKAGGNYNMALQDTEKGVVTRFPPEPSGYLHIGHLKAAMLNDYFAHEMYDGKLLLRFDDTNPSKEKQEYQDAIIEDLALVGIKPDRTSFTSDYLQELYEYCIRLIKEGHAYADDTDQETMRDQRMKGIPSKNRENSVEINLALFQEMKVASEIGLKNCIRAKMSVDNPNKAMRDPVIFRCNLLPHHRTGDSWKMYPTYDFACPIVDSLEGVTHALRTTEYTDRNPQYQWFLDTLKLRHVYVWDFARMNFIRTVLSKRKLTKLVDSGVVWGWDDPRMPTIRGVRRHGMTIPALRDFILKQGPSRNIVVMDWTNFWATNKKEIDVFASRHTAVESRNSVRAKITNGPDKIYFEDKPKVPKNPSLGTKSVAFSSNLILDQADVSLMEANEEITLMAWGNAFVRKINGTNPITDIELELHLEGDFRRTKKKVTWLATEQNLIAAETWEFDHLFSKDKLEEDDNWEDFVNRDSAKSTEQLCDLNTKDLKVNDIIQLERKGYYRVDKQFSDGGKLVLFGIPTGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB13</accession>
    <name>A0A0B1PB13_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000222">
        <property type="protein sequence ID" value="KHJ35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB13"/>
    <dbReference type="HOGENOM" id="CLU_023951_1_0_1"/>
    <dbReference type="OMA" id="PYEIGND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="52085" checksum="74AAF5FE533190C9" modified="2015-03-04" version="1">MITSPATIHYLSTMKTLNKTPQISARYSNEDTRACAESPLTFPAILTRGNRRTHRNKRSGLRDQLIQMTTHERVYSIAKLLALTSIPPLPKNKIRSLGTTKQRSTVNAILENINVSEKECDFSTDGSPWDIFLNLQDEISKLYELKRTQENALNKLVSKPIFNTSDPSRPVLPHFQSHLVIPESFETFKLPSRQSKKLRRKPLQLPRQLCLNEDHPLFSLRSNLNYEDQDQLLEKLTDLHEKPHLKSVDKRSIFTPQLHLKTSFHKIKYSLNSISSLLSPSLKSINPSSSPSKLDKPDLSNTRESLPIRLELVPTSQLRWYLNPITNLPIEDHKSVLYKTKGQRRCMVSIQMQTYKISISNDHPPHHVISYRTKQINEDQSAKTLVVRRRDMRENCDFLRVAVMEMLMRKRGKLDDQEPGKARLILPPRTLTTRPPETTACGIPLRWVPLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB28</accession>
    <name>A0A0B1PB28_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2728</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB28"/>
    <dbReference type="STRING" id="52586.A0A0B1PB28"/>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="436"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="624" mass="70605" checksum="EEF5ADA543454FBC" modified="2015-03-04" version="1">MATEKKILPIEGEKNVLITSALPYVNNVPHLGNVIGSVLSADVFSRYSKLRKRPTLFICGTDEYGTATETKALETNKTPRQLCDEFHKKHKDVYDWFDISFDYFGRTTTEQQTIIAQDIFLKLHRNGYLEERTTKQPYCESHGKFLADRFVEGTCPKCADKGARGDQCDKCGSLLDPLELIEPRCKLDGATPVTRNTSHIFLRLDKVQQPLEDWVATKISEGGLSPNSVSITKAWLDKGLEGRSITRDLEWGTPVPLPGYENKVLYVWFDACIGYPSITANYTKDWELWWRNPENVKLYQFMGKDNVQFHTIIFPGSQIGTGDKWTKVSYLSATEYLNYEQGKFSKSRGIGVFGDSVKETGIPPSVWRYYLLANRPEVGDTQFEWKAFIAANNSELLANLGNFVNRLVKFVNAKLNGIIPQFSQDYDDETFDFKGLTLEINTLLDEYVADMEAVKLRSGLKKAMEISAKGNLVLAGRLDNANLATLPIRTNHIIGYCINLAHLLASIFSPFLPTTSTSILKQLNIPIAPIRNVWKFELLSGHKIGKPEYLFTRIPDTKEAEWREKFGGTQASRLEEKKAKAKKVADKARDKERKKEKKKNATNIENSIVNPSSLVGIETVLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG0</accession>
    <name>A0A0B1PBG0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000754">
        <property type="protein sequence ID" value="KHJ34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBG0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBG0"/>
    <dbReference type="HOGENOM" id="CLU_032494_1_0_1"/>
    <dbReference type="OMA" id="LFEWTRF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48861" checksum="E4CF5EF6C3D08AE8" modified="2015-03-04" version="1">MGGTAFAQHQSPISTPRMPCEVYKSRLRETKALLSQFYDHVLSPIEAPGKDSYGDLDILLFKPKISSLDDAQRSREDIAEQIKTILGAKAVIVRKGDPVISFAVSSPDNKCSLEEKKAVDEIYVQVDIQILSNYQDFRYSYFHESHGDLWTILNYIIKPFGLRVNNKGMYICIASIEATNNKKSRVFLTSEPEKILSFIGLDPEIWWKYFPSMDNMFHYAASCRMFNPHQFQWALEDTSNSENLVSLNITKKQWSRKDRVRLVKRPVFAAWFNDFIPSCLSKHLYEKPDLFLTREQIKYEVFSRFNVKKEFEEKEINWALTKNDEQVINEGVRKSVPTEGVDPALRAAGIRVLKDVILDGNLWKDNMRPIEVQRDEHGFHDIEKVKRWVSENWHMAGKIGLARQLEKSILNNQKRLAEFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBL5</accession>
    <name>A0A0B1PBL5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribulokinase uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBL5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBL5"/>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="OMA" id="EVWFVEV"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="235" mass="26766" checksum="2870F99814EAB153" modified="2015-03-04" version="1">MDQQIDKLIQKLEAMYLKTPPDQRLMIAISGIPGSGKSTFAKVLTTRMNLTCSSSTERVAVCVPMDGFHFTRAQLDAFPNPQIAHARRGAPFTFDAQSLFHLVKALRQPLLSSTSPIYAPSFSHIIKDPINDDIAISPKARIIIFEGNYLTLDFELWRDIADLFDERWFLKIDFDVAKSRLISRHLAAGIVKSKDDAIKRVLENDLVNGKEILEHQYRVDEVLIIKENEEWKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT4</accession>
    <name>A0A0B1PBT4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001038">
        <property type="protein sequence ID" value="KHJ34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT4"/>
    <dbReference type="HOGENOM" id="CLU_005386_0_0_1"/>
    <dbReference type="OMA" id="ERTKYWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="447"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="725"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1014" mass="118864" checksum="8C2D8BCE3F660951" modified="2015-03-04" version="1">MVKIDQDYEYLTEEEKRLKEDRDKVKYWKKWGPYVAERQWATVREDYSADGDAWSHFPHEHARSRVFRWGEDGIAGVSDTHGLQNIAFAFWNEEDDFLKERLFGLSNPQGNHGESIKEAHFHQDNTPTHSYMKLQYKYPQRKFPYEELVEENAKRGKSDREYQILDTGVFDDNRYWDINIETAKESEDPEELLFRVTAWNRGPEPAPLHIIPHVWFRNTWSWGYEKAKEKPSITQINETVAETYHPKLGKRYFDLSPSPGIGPSGFDVLPELMFTENDTNFELLYGGKNHQPYVKDAFHRYIVNQEKNAINPNKEGTKAAAWFSFNESNGVAPNECAVVRFRISKKFDDYMDEELFDEIFEKRKDEADEFYYRINPMPVSEDLRNIQRQAFAGMMWTKQHYHFIWSQWANGDPSQPAPPPERKAIRNVKWRHLHLDDVLSMPDSWEYPFFAAWDSAFHCIPLAMIDPDFAKKQLDLFTREWYMHPNGQLPAYEWNFGDVNPPVHAWATFRTFKIERKIYGRQDLDFLERVFQKLLLNFTWWVNRKDFDGKNVFEGGFLGLDNIGIFNRSEPLPTGGVLEQADSTGWMAFYSLSMLNIALELAKHRRIYEDIASKFFEHFILISDAMTYKSGSKEEKSLWNEDDGFYYDAISWGGPYSQQLPIRSLVGLIPLYATLTLEPELLNKLPSFKKRIDWFIENRNDVAERNMASIRKRGKGNRILLSLVSKDRLEKILARMLDQDEFLSDFGIRSLSKFHQKNPYSMNVNGQEFKISYVPGDSDTGLFGGNSNWRGPIWLCVNFLLVESLQRFYIFYGREFEVECPTGSGDFMHLGRVSEEIQHRVQHLMVRGDNGRRAINDGNDILDFDENWRDNVWFYEFFDGDSGRGLGASHQCGWTGLIARIIHDTGTNCRLPQTPRTPSTGMAHYFDDIFHRHISYDRAKSPPAIMRRSSTARSIGARSDWDESRSVDLFDPEREEQKKIADMHTEKYISEQLRCLVENNFMDRSGDEYEAQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBW0</accession>
    <name>A0A0B1PBW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000870">
        <property type="protein sequence ID" value="KHJ34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBW0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBW0"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OMA" id="YTVFTPY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="336"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="434"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="537" mass="61529" checksum="F4F1AB9C871EAC01" modified="2015-03-04" version="1">MSNARAQDYKDKRIPRPIDELNSALKDTFKQRGVISPGRSVVHWFKSDLRLKDNHALSAASEKAQKSGVPLITFYIVSPEDYEAHLRAPIRVDFILRSLKTLQDDLAKLHIPLYVETVEKRREVPLRIAQLLNNWGTKHLFTNMEYEVDELRREAAMVRDLASQDIAFDVRHDTCVVPPGKVVNGTGNQYSVFTPWFRNWVTYLHSNLDLLETFPAPIANSPSINSDPNLKSLFNQLIPVAPLNKQLSKEEEKRFTALWPAGEKEAFARLEKFCKERITSYKKLRNFPAETGTSSLSPHFAVGSLSSRTAVAVARERNGLKKLDGGDEGIQTWISEVAWRDFYKHVLVEWSYVCMYKPFKPEYTNIQWECNEEHLNAWKEGRTGYPIVDAAMRQLTHTGWMHNRLRMVTASFLSKHLLLDWRLGEQFFMLNLIDGDFASNNGGWGWSASSGVDPQPYFRIFNPELQSEKFDKNGDFIRKWIPELKAVKGAKAIHDPFGRGAISEAKKGGYVKRIVAHKEARDRCLARYKEGLMKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC29</accession>
    <name>A0A0B1PC29_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000095">
        <property type="protein sequence ID" value="KHJ36242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC29"/>
    <dbReference type="STRING" id="52586.A0A0B1PC29"/>
    <dbReference type="HOGENOM" id="CLU_074922_0_0_1"/>
    <dbReference type="OMA" id="VYATLIW"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="53"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="26679" checksum="E81B61EDCEC656F2" modified="2015-03-04" version="1">MENVRPLASLTLTHVHYDPHDPISYLCAWLALIPQGLCIVYVTLIWSTREIEILLMFAGQMACEALNFALKRILKEERPKIMHGKGYGMPSSHAQFVAFFSTSLTLFLLFRHFPKPPTPCHTPLSLISRIILSALSIANAGLVAWSRTYLNYHTTKQIVVGFLAGVLVAILWFFFVMAIRRFGILDWILNLNLVRLFRIRDMVVEEDLCQAGWEKWESKKLLSAELNRKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC52</accession>
    <name>A0A0B1PC52_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000614">
        <property type="protein sequence ID" value="KHJ34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC52"/>
    <dbReference type="STRING" id="52586.A0A0B1PC52"/>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044837">
        <property type="term" value="P:actomyosin contractile ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="138"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="287"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="411"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="536"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="73621" checksum="413529C621C97A0F" modified="2015-03-04" version="1">MNVIKLQRKYPHFKNDEIFGLQDAFRKLDVDDKGYIDEATAIKATQASERKPYDVVRQTLKEVELDSSRRVELDDYFDLISKLRDSSRVETHQSTGPRSPHQSGNNSYSNINHSSRGSIGGRIQVKGSSANVTHTINEDERTEFTRHINAVLAGDIDIGNRLPFPTDTFEMFDECKDGLVLAKLINDSVPDTIDERVLNRPGNKIKTLNAFHMTENNNIVIESAKGIGCSVVNIGSGDIIEVREHLILGLIWQVIRRGLLAKIDIKIHPELYRLLEEDETLEQFLRLPPEQILLRWVNFHLNAANWPRRVSNFSSDVKDAENYTVLLAQIAPDKCTRRPLQTRDLLQRAEQVLQNADSLNCRKFLTPSSLVSGNPRLNLAFVANLFNNHPALDPITEEEKLQVEDFDAEGEREARVFTLWLNSLDVEPAVNSLFDDLRDGYILLQAYDKVVKGSVNWRFVNKLPSNGTEISRFKAVENTNYAIELGKQNRFSLVGVQGADITDGQRTLTLGLVWQLMRKDISETLSALAQRFGKREITDTDMIKWANDMSKKGGQRSTIRSFKDPSIGTGVFLLDVLNGMKKNYVDYDLVTSGKTDDEAYLNSKLSISIARKMGATIWLVPEDICQVRSRLVTTFIGSLMATHERNSKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC92</accession>
    <name>A0A0B1PC92_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC92"/>
    <dbReference type="HOGENOM" id="CLU_329012_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="3">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="2">
        <location>
            <begin position="665"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="924" mass="106614" checksum="941B636A523D2105" modified="2015-03-04" version="1">MKQAVLPTNEEFPMNGNRRSEDINPARASTSNEIGHKNISQQYSPTRYYDSQALVSMSRKTGTARSLMKTTERVLYQKFDVDALRIAARDGDIATASRVLDVKPSSSDAQTLYNAAKGGHDAVINLLFALGDFDPDPEPIKDLPHEFSTPILAAIGKDHHLEVIKLFLGNSRFNPARRIRGETYYEIAKRRGGSKWQEEFILLKNAFEAHQKIKDIQSSKAQVSGAQYDNRLSDSEFNKNLRREDEPNSRSHKYNLDPNLKDREPKRPQHRKHLSLGPTQDGLSMSKKITGKLKNEDDSPGALSEPELSLSENQLIVKPRRKLLSRKALKDERELERALERLRRERCTSSKSIDIPRGEKERPQSNSKNDQSRDYSASIEVRSPHKYNNSNQNKKDSTFDSCISDKGNHQACIKNDYKDRSVASESPVNRFSNMENMPRQENKENTTYSSSEEKLIKKRKIEGDKYNLSQAINSDKSQGNLTKNAQNSDTREKKFFLTKRSNSPPIFRNNNKENIVTNNLSDDIISKLQDVETFHASLKPIKKDAEALKDSNKRSRSLPKVAMGSKNIREKENIYIGEEKCLAWNSSEKGLRDRTERQQNESIRHVNQIQIQEIEFQKKTHVEQRLLYLEQERLKREEQECRRANMIEQQQLELIRNEKEKNQKRLSKLPLLLKWFDQTVQPKTPDIAKLFSYIVGYRYDSINTEATGKLGEDDPWMLNTHVAILLGEKDLQLSRYTAWERLVLTTPQKRGVWSTFNGIFLLLDGSLSCLRQQLPIDTESMDEVIEKNKKQFLDLDLFLVKVTEFMYIVPNFPHLRGIKMAVLYRELRIPQDADQLDLSGLIPGWNQNLQNRVDHRFVPLPKYYVDGIIVSQTEEAKTRILEKPPPLDIFPRRMGLTRVYPGDSDYEEICKNKKSGKFKNTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCN8</accession>
    <name>A0A0B1PCN8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative wd 40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCN8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCN8"/>
    <dbReference type="HOGENOM" id="CLU_002615_1_0_1"/>
    <dbReference type="OMA" id="IIVWSCF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="786"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131814" checksum="B1F7CCD8D73C6D5B" modified="2015-03-04" version="1">MSIQKHEYILNPITALQFYQKNADSKILLAGEGPYLKAYDIPSCRLVSQCQIFKSQIIHGIVVWEHLKDKNSLCVAIWGGTQIFLLSKSQIDQLLDENVKLIIDTTLTVSDWVLDVSISPFDQNVCVIITAHNTLIKAKLDGKTKNVEFEYLISPLNIGLYCAHLIWDSSSTILIASGTVFGEIIVWQYCFDGTTSFFSKLKGHEGSIFGVDISSTIIHSDGRAGRLLASCSDDRTIRVWDLRAGLKNDFSTKIPIHKDKTGFGKWNPKASSGSVEGQIAMAIGHASRIWRVKFMSNYSENNEEMIINLLSFGEDATAQQWSLRVRPDGYMHQSPDIKFNSDSNCRLISYDLTHCKTFSFHSGKNIWSYALHHIGQDYYLSTGGADGKITLYEIKLRGFNSSQYSKSNLGIEAVTDNIFSIDNSAHALKLCDFQEDLECYSSTLRVVSQLERKEGLLAIKHSFNRYAFVSDFEFLVTTTSGCIVRGLINNILSMTELSLSSSITEDIRSYTIIESFPKIGIAYFTGTSGKIYAYDHNKNVLIVGNVEGKVANMFKIFDEIDQIYALLVTNLHCRLATIFYIDKHSCSFLETHKVTLPKKFVVTSVALVSDLLIFGSRLGLLAIYELRQLETPLEAYEVMKGNDRDAITSITQLKTFKKEQGVQYFVCTSRNGTYSIFSLAVYSTNTSNAALIQLIHRGTPPLGPMIENAWFEGQDLLLYGFKGKNFIVWNETKQCEILNVECGGAHRSFTYISFGEEKGGGYFIYTKASKLHLLCYKLPSHQVLKQGSHGREIKTCAISQDQNLIATGAEDTMIRVWRYEIGQKEDKRLDCLAVVKRHTTGIQKLLWAGSRYLFSSGGNEEFFVWAINSIPNFGVGLVCEACCPYKSEERDLRIINFDVVTLSDLNTDTKLLISLVYSDSTLTTYVYSRRTGFTLVATGRYTSSCITQIRQFNITKSQVSILTAATDGVLALWSVRITDIDASTYTHGEINLLSVKKLHQNTIKSLDIYTTKEQIFVLTGGDDNALGVSIYDTCELLRKPTYCFIVESAHTAAITGLAIIHDCIPENCSLENVREKKCHRLRIVTSSTDQKIKIWVLEVPFNNAITTTTSLTNHIISSNQNEIDNVTIKLENNFSTPIADVSDLITFLQEKEGSSFLNLRMLVVGIGMEVWNVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP0</accession>
    <name>A0A0B1PCP0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP0"/>
    <dbReference type="HOGENOM" id="CLU_006601_2_0_1"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="195"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="583" mass="65761" checksum="BA96D1146075B67A" modified="2015-03-04" version="1">MAATLSTTKIGLSQSLPSPKYTGDDEDIPLHAQQRGPRILGARVLDESQIVLKKSGPPKYGQRLGWRPCGQEDFGDGGAFPEILVAQYPLDMGRKSQGPSKTLAVQVDAEGKVKYDAIARQGHNEKRIIHTSFKELIPLRQRADIGEINLDRPSDEEVIASTQRTKEALEKLVSGAVAAQKPKNVNVGTRKEPTFVRYSPANQMGDNSKKKDRILKIVERQQDPLAPPKFKHKKIPRGPPSPPPPVMHSPPRKLTAEDQEAWKIPPPVSNWKNPKGYTVPLDKRLAADGRGLQDVTINDKFAQFAEALFTADRHAREEVKQRALMQQRLAEKEKAQKEEHLRILAQKAREERAGINAGSRSERKSRSQSERYSDSDSSGSNDDDDDNDEIRERERARAERRREEERKLRQSRMGAERRVQMMARERNRDISEKVALGLAKPTQSSESMFDSRLFNRTSGFDSGFNEDQAYDKPLFAAQDAISSIYRPRHTEDWDDDEAADAEMGKFQKNQRFGDALGKGIFKGSTDVEAREGPVQFEKDTTDVFNVDEFLNKVSEGTTGKRQNIPQSEQDERVLKRTKVDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCR9</accession>
    <name>A0A0B1PCR9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative spindle poison sensitivity protein scp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000866">
        <property type="protein sequence ID" value="KHJ34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCR9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCR9"/>
    <dbReference type="HOGENOM" id="CLU_018150_0_0_1"/>
    <dbReference type="OMA" id="YDMIPTI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="481" mass="52380" checksum="6FE56111961C7590" modified="2015-03-04" version="1">MEYRHMSTGSLNIPPPQAINASLCLKNSGSPWATTPMTRFEGPRSPPNRQNTSHVPCKFFRAGTCQAGNSCPFSHDPASTTDNICKYFAKGNCRFGPKCANIHVLPDGRRVNYTKSMGPSGGVGGGSVVGNGGHLNVGGQVSMDYYYSPKPGPVLTNSLLCAYVKPSSPYRHQKFMGYREGNYSARRKSSVDITIPSSDVGYNSITASRADEDVRRFGLGSSWPGKMLNTMDAPMPAPLDTNGVSWATRQSSISTSVPFNIGLDPPSDSSGTREGRSTDTLKNLRNSVFGEEPRERFTDQVASPPINISDEYLGVGNRHASGPTTMKPISVNAKSAVDKDWVASFTFEEDYLPETLKDLMTPQEKARRGSRNADEEARYFHNGNGVSCNENSSKIGSPSNASPSRWGSLFQRQQQKEEEDRARISPFNHIGSPLRKTSLHPIASPKAGPIARPNAVNESPRRSSTSIITQQLHRTQISDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD24</accession>
    <name>A0A0B1PD24_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD24"/>
    <dbReference type="STRING" id="52586.A0A0B1PD24"/>
    <dbReference type="HOGENOM" id="CLU_1950408_0_0_1"/>
    <dbReference type="OMA" id="MILPRNA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="129" mass="14461" checksum="20C8F366789EFEEF" modified="2015-03-04" version="1">MAHFSAEPLNTARSALSRRAYGYCVRYGRYGYYSTCDRSFWSRFGRWILAGIMVFLGVTVLITALICLAIRKRRSRRRQTSLYTPAVGTTQQGYFNGSQTYAPPHNAPPKYGGPQPYGGVTQPSDAHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD37</accession>
    <name>A0A0B1PD37_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000455">
        <property type="protein sequence ID" value="KHJ35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD37"/>
    <dbReference type="STRING" id="52586.A0A0B1PD37"/>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="352" mass="40329" checksum="80D8E66DB9562AED" modified="2015-03-04" version="1">MALLVDKHHPRSLEQLTYHFDLTKRLRALAQSSEFPHLLVYGPSGAGKKTRVVATLKELYGSGVEKIKIDSRVFVTTSNRKLEFNIVSSVYHLEITPSDVGNYDRVVIQDLLKEVAQTQQVDQNAKQKFKVVIINEADHLTRDAQAALRRTMEKYTPNLRLILVANSMANIIAPIRSRTLLVRVAAPTEEEICMVLERSGKREGWQLHKGLNERIAKESKRNLRRALLMYEAVHAQNEKVDDKTPIPPPDWEALITEVANEINDEHSPARILLVRAKLYDLLTHCIPATTIIKTLTFNLIPLVHDDLKADVIKWAAFYEHRIRMGTKVIFHLEAFVAKFMRISEEFVMHSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDG2</accession>
    <name>A0A0B1PDG2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDG2"/>
    <dbReference type="HOGENOM" id="CLU_1023763_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="272" mass="30860" checksum="10846C68FB3CD225" modified="2015-03-04" version="1">MSTAVSLKYPVVKFQATVTSIRESQLVYRELHPTSIIAFLNSNKTEKLSPSSQSDENKKCAYCNRRGHLRESCFSWLEKKTPDGSKWSTKNPKKAAKKHKLKEKSSRRRGEAKKNSRNNSSINTRIVDDTKHGAANKVNKIAAFEEWRETWTGLHKVWHSTYRTPADPKVWKAATIAIDKNTGRIILTNRDLSHDLCSFTAVSPNPAGRSSQHMVLGCHQWAEGRGEILRQAKDRSYEAMMKSPYVNNIDSHLHGPRGHLIGLNEIKSKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDG7</accession>
    <name>A0A0B1PDG7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1097</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDG7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDG7"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="OMA" id="RGKNAMD"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="226"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="434"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="614" mass="68463" checksum="9DA2DA8E1754E7AF" modified="2015-03-04" version="1">MSPSLKSGKALQKEVESTDAGELTSDKNNATRKSTKDSGKTDDEEEIEKKLVRAAKKARKEKRRLEKASREKKDASNSIIDTSITAAESNSVSDTKDLGDKETRRKKKKVEKHRKRSSHPIESTNEQDESIEERNHQESVPPLSERNGNQEKCYIQNEELAAQPQDNIDAFLADNFIFITDPLSSKASSVSLRPITKFSYLPITDPTLLVYLKNFETPTPIQAATWPYLFAGRDLIGVAETGSGKTMAFAIPCVTRITSSIQSKSYVKGVRALIVSPTRELAMQSYDQIHQLCKTSGVKAVCIYGGVPKDEQRKNSKKADIIVATPGRLNDLINEGCINLSKVEYLVLDEADRMLDKGFEEEIKKIINTTPELGTRQTLMFTATWPESVQSLASTFMKTPVKILIGDNKAGDLRANNRIVQKVEVVEPRNKEYRLLQILKEYQSGSKSNDRIIVFALYKKEATRVEGFIRSKGFRVAGIHGDLSQEQRTRSLDAFKKGNTPILVATDVAARGLDIPSVKLVLNLTFPLTVEDYVHRIGRTGRAGKQGLAITLFTEHDKAHSGALINVLKAAKQEVPEELLKFGTTVKRKEHEAYGAFAKDVDMTKKAKKTKFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDY8</accession>
    <name>A0A0B1PDY8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative gamma-glutamyltranspeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000348">
        <property type="protein sequence ID" value="KHJ35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDY8"/>
    <dbReference type="STRING" id="52586.A0A0B1PDY8"/>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_1"/>
    <dbReference type="OMA" id="EGNMVSY"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="603" mass="65809" checksum="A84B842871DBC58A" modified="2015-03-04" version="1">MPLRAKEKFQRFNSRRSVVHSTEGMIACTQPLAARCGLKILEAGGNAADVGVAVAAGMSLTEPTSTGLGGDMFCLFYNSKTKKIQGLNGSGRASKKSSLEAIRGDLGLQDGVEGKIPTDSIHAVTVPGAAAGWVDTIEKFGSGKLSLEQILAPAIELAERGFPVSEISSHMWSNGTRILYKASPNYAELLTLDQVNNTLRAPRSGEIFRNPHLAKTLRLLAVNGKKGFYKGQIAKEIIRATKDRGGFLELEDLELHMKTGSEIISPLSYIFRGQGYVQEYKKFIDKPSSNVNEEKCGVKIWECPPNGQGIVALQALALIEILEEKGKIPKFTKEQHNSVEYLHALIECLRISFADASWWVADPLQSKIPISKLLSREYLVERSELFDPNKASKKILDHGSPAHNHSDTIYFSVTDKEGNAISFINSNFGGFGSGIIPKNSGFVLQNRGSNFSLTPNHPNAIGPCKRPYHTIIPSMLTNAHDESLHSVFGVMGGFMQPQGHVQVFMNMIVFKYDPQTALDAPRFCIGAENIPSDTMGRKVKLEEGISETVCEGLRAMGHDAEIVRGFDRRIFGRGQVIRSNLENNLSVFSGGSDLRGDGAVFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEE1</accession>
    <name>A0A0B1PEE1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative phd domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000577">
        <property type="protein sequence ID" value="KHJ35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEE1"/>
    <dbReference type="STRING" id="52586.A0A0B1PEE1"/>
    <dbReference type="HOGENOM" id="CLU_025079_1_0_1"/>
    <dbReference type="OMA" id="CHDPYID"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="213"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="482" mass="53028" checksum="2395E595838BC36A" modified="2015-03-04" version="1">MMSTKDKSQTQKIHRNEDSTTITTDSSPKYTPQFSAATQMILERIHSGNSSTFSSMGISGTIAPPPGYEDMRRCVLQTMRTSMNMQIPVTPARDKNIKPKYTRSTSGSGLSITPTSISASNVGKGKTSTKNSRAKTSGKRKRGKDKSDESDEDLNENMLQLSADSEIDDSDALTKLPKITQSGRHIVKPTQFVPATYESYSRRRTPSRKAQEQALCKRCGRGYSPQNNLIVFCDGCNLPWHQNCHKPMIPDDAVQVESAHWFCAECSRKKGIKSGYETTPKGVSWARKSIEEKKAYLSSQSHSQLVALLLQATYLHPDIPLFPWPETRKVQSQPQKTLLFPPSPHSSTVGTLSCFEGNPLSPIKLIRKKQPLPPQPNITFLHASSKSPIAFSQDPQISRESTPASPPYPRPGNGLMAKLGPDDEDIDWLVDTDDYNAFSHSVAENVGDHFSKNNDTSKLAIGLGDVNTSNVDGNLNGISIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFI2</accession>
    <name>A0A0B1PFI2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000438">
        <property type="protein sequence ID" value="KHJ35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFI2"/>
    <dbReference type="HOGENOM" id="CLU_151460_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="87" mass="9679" checksum="B8A2D90E9A4611D9" modified="2015-03-04" version="1">MLNPVKSKSSPSRGAGVNASYALHVWDSQEDSENPSFPSGLPFITVGLNRLRFYINFPPASHDWPKEYRVKGSILSQRTSDESKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFV2</accession>
    <name>A0A0B1PFV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative telomere length regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000283">
        <property type="protein sequence ID" value="KHJ35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFV2"/>
    <dbReference type="STRING" id="52586.A0A0B1PFV2"/>
    <dbReference type="HOGENOM" id="CLU_005799_0_0_1"/>
    <dbReference type="OMA" id="AGIMVKL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="598"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="963" mass="108043" checksum="7A87FF0071CE1476" modified="2015-03-04" version="1">MDGHLTQVSTYKRTEKKSNGHQESKSKSSEICLSITTAKEALKFLQNEPNYQDLISILRYICQQNSDIDICSPSPLSAQLVHVLVSDIVPSFWNILSGSDFQSCLKIKPELRLLISCLQNIASLNSIILRLKQYIQLSKTSNNVIGQGPSIQEYLKIYLDLLGALLSDDGLIEKIWRNSIKNLENPLEQRGIWKEILVKFSNGEIIGICAEAEDLFKNLSKNFNQKCWLSCGRQYSHWLARNILFWARNVPKTSEIDLKCCADLFGKSLSLGYPDFIVQEIVTGLLLKKDNLPAHFSKLCANLSSSDQRKVTFSVLKLCSTQFLSSNFVNEESEWWKKDALSISAVAALISIMISGNEKIKSHLLTWLSGNFGAGVGEGISIRRSVIAAISNDKCFMENLLEKCLKQFGDHLYIRHTPTLQQEAHCQILLLTAGCVHRHSPLRIRIIVKSGANLSLVSNRLASSSNRARFLGMIVGEALSTLVDKDENRMDFKIAEMNNSEAKWYKSLIGVVDSVGTLCFLVSKEMARNVKKAAILEHEQTIRPMPLKLIEFKNLKVEEADHGGRELDGLDIYSKPDSDPDDSDDDPTLINRKKLSTPVYIRDLITYLRNIDSFDHQRLGLSTAASLIRRKANFGTEASDHAEELATLLVGIQDKYNIENFSDMRLAGMIALVVSFPSKMGKWFSNTFFEGDYSISQRSSILTALGLGAREVGGLGSYKNIERSNNSADAFFPSETLPANLEKYYGSQESTLVDALSYRLERNMITPMVGSLADKLTGPTILKIRTFSSRMKVEKTRPKPSINKLSKIVGESFLFPLIGKFFIHSHSYMVSKRSIIFQPFLLSHFIKTLALILHAAGPSTPSLSEMTTEFWDLLLGLQVLGINERIVYEAVCFAILNLLELNSERSEMVQAYGHRLLDTQKWVNDIVCRLGDGDERCKMLGVGCMVKIQEIVEKYQKKLSGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGP2</accession>
    <name>A0A0B1PGP2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000294">
        <property type="protein sequence ID" value="KHJ35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGP2"/>
    <dbReference type="HOGENOM" id="CLU_2529143_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="84" mass="9990" checksum="51108FB6A47D4B9C" modified="2015-03-04" version="1">MWSSFRCLEDSSVAAEITSLADFETALKQRFQDPYLVEKASRIIETLYRKDLKFNDFITIFKNNCIDSIYGNLEIRNWKVMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHE1</accession>
    <name>A0A0B1PHE1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000093">
        <property type="protein sequence ID" value="KHJ36246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHE1"/>
    <dbReference type="STRING" id="52586.A0A0B1PHE1"/>
    <dbReference type="HOGENOM" id="CLU_034666_0_0_1"/>
    <dbReference type="OMA" id="FQHENPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="516" mass="57656" checksum="EA270116A0FE6250" modified="2015-03-04" version="1">MENSPLTLAFDYARAASAATQASDVDLAISQHTLAAKEFSKAANSTGSTEAMRTLHLLECHHQRLSQLMRPASENNLSSTEDQEVQKAVIKRSTPSTVVAELRGTKSDLGARSLSPHRTSQTLQQSRRFPPRNLSSSIASNLATARGIRANYTSQSLSPSISKNLTPASLEALSRRDGRKSSVPTISEHPNLIYSTSTVSSKKNQLKSESLTIAQNPRSDEGFSRFYSTFENIVSKLTAPLAFAGLPLTIDESSFPGDSSNVKLPKSTPLSRERAPIDDLDLKKYFSRAALSASTRDEYGVNDSFYVVPVTGHTVSYAHILSFDQKEKRRMAVSRIPGNPDATTDLNDDEDFVDARETPMPYTSSIQRDNSKELSSREKDNKIEELTMENASLKTAIDKLSKRLHTFEISAQYNSMALAESMRMMRDFSPARKEIDKGTEIKIYQDEKSLRERVRELEETMRIRARENDNLKKEKEKLMGIVTRYRERWEKLKEGAKSRRDGKDVGAVDVKENITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHQ9</accession>
    <name>A0A0B1PHQ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000153">
        <property type="protein sequence ID" value="KHJ36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHQ9"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="138" mass="15460" checksum="6DD1921E22E8739D" modified="2015-03-04" version="1">MKAISDKRLFLRLPQEFEWCKLSPAGIRELIVKKLIISPSLMGKVKLVHSGFALSPSISETREQILKAGNGPFLSGVKWEPATNWVSVLVPTAPAFIHMEQGKIEVNKTMFSDEIERVCSVRPAHLKLYGRNNPEAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUH1</accession>
    <name>A0A0B1NUH1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005629">
        <property type="protein sequence ID" value="KHJ30017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUH1"/>
    <dbReference type="STRING" id="52586.A0A0B1NUH1"/>
    <dbReference type="HOGENOM" id="CLU_044590_1_0_1"/>
    <dbReference type="OMA" id="IAWRTAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="156"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="358" mass="40954" checksum="F0240A81C63F7FD9" modified="2015-03-04" version="1">MTSENVEDRISIPIIDSHVHLYPSTELNDITWFPTTSSLYQQYSLDDYLKILDTKSPTYSLSFTGFIFLEVDRRQDFSTLDAENEVKNWEIPLREVEFAKRVALGTPLPGEGHSAEQAKLCRGIIPWAPIASGEQVLERYLLHVENHAGDSFSKIRGFRYLVHDKPRGVMLEDNFIQGLKWLGRNKFVFDLGIDQHRRGKWQLEEAITMIERAHDGVNPEDRVHIIINHLCKPNLSIYNQSDPVFIAWRTAIFKLSKFSNTYLKLSGGFSEMSDTLKTATVNDIFDAMQPYLAVTLATFGPSRIMFGSDWPVCTVGVVDAWRKWFLIVQRFCSLASLTPEEMRMIFSGTAIKAYGLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUM0</accession>
    <name>A0A0B1NUM0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hlh transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005368">
        <property type="protein sequence ID" value="KHJ30067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUM0"/>
    <dbReference type="STRING" id="52586.A0A0B1NUM0"/>
    <dbReference type="HOGENOM" id="CLU_017046_0_0_1"/>
    <dbReference type="OMA" id="MQHKQLS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="512" mass="56773" checksum="01BC74B17683065B" modified="2015-03-04" version="1">MASSVPAPKLPTGLVSVLNRPENLRDSAYFSTKDPSSKHNSIQSSNETHSADQTATRVDSVSTVDVIPSRRFSGSRIASLSSPVSGTMSVASIVSPTYQGFSQTLHEPGSHNSGISTTSAVSVLSNNEELRRESVDSRLGANFGDMCLANSPYASANPSTTSLQSNLAQQRNPSLALQDRGSVPYLISNGRLPRYSRIPNTESMINGSRIAPLITGPAQGAIARASEPTKGQAWAFPEEPIQRQPSTLSSRRVSLTQQGSQIFNESRRESFTESVASSRYTTDSCLPPGQRRLEDGMPSDYTKASSSEYKASKQNHNVQHRQVVELQNDGESLNNTQPYSRTPELRVSHKLAERKRRMEMKDMFDSLRALQSVDRGAKASKWEILSKAITEHERQAKLIDDQKKAISRMESQLHRIEIELNDARRDSSNVRDENARLRSEITSLRTPRNRAYAGPESHPHSYNGPGIEQKSQLPPFRSLQVPEVMNGVQYHHEQHSEHVMNKPQSILSFNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUN0</accession>
    <name>A0A0B1NUN0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01005277">
        <property type="protein sequence ID" value="KHJ30077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUN0"/>
    <dbReference type="STRING" id="52586.A0A0B1NUN0"/>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="46385" checksum="6431535C255AD4B3" modified="2015-03-04" version="1">MNKQKVCLAYSGGLDTSCILAWLIEKGYDVVCYMGDVGQEEDFEAAKAKALKIGAVACYIEDLKKEFIEKLCFPAIQCNAIYENVYLLGTSLARPVIARSQIRVAQKENCFAVAHGCTGKGNDQVRFELAYYALEPKIKVIAPWRLPEFYQRFPGRKDLLDYAERVGIPVTSTKSKPWSMDENLVHCSYEAGILEDPDMTPPDDMWKLTISPLKAPDEPEDFTLFFEKGIPKKIVTSSKTVTDPGELFFEINTIARRHGIGRTDIVENRFIGIKSRGCYETPGFTCLRLAHIDLEGLVLDREVRALRDQFVTFNYAKILYNGLYFSPEREFLESSIEASQKSVNGQVRCRAYKGNLIILGRSSETEKLYDACESSMDEIGDFSPIDSTGFISIQAIRLKKYGICKTANGEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUT0</accession>
    <name>A0A0B1NUT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005025">
        <property type="protein sequence ID" value="KHJ30132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUT0"/>
    <dbReference type="STRING" id="52586.A0A0B1NUT0"/>
    <dbReference type="HOGENOM" id="CLU_1295257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="23724" checksum="3766055A9E720BAA" modified="2015-03-04" version="1">MMTKYKIAVEDKQTLDQRHAARSTILQARDLLIQAYTLTPDRGEQAQILDLLEIFREYTERGILKKASSIIASQVANLETAARQIETKAKSLTKAVTPALPLLNQSQKNSRQQQAQQQVQSQSPALGQSQPKPLHPPSKLTSMAAIAAHGTLQSSSPLEWTVVGKKQNQNNKNQTQPSAKKPKITRRVILIQRPESVVIFQPRDCTSMGQREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUV4</accession>
    <name>A0A0B1NUV4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01004968">
        <property type="protein sequence ID" value="KHJ30152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUV4"/>
    <dbReference type="STRING" id="52586.A0A0B1NUV4"/>
    <dbReference type="HOGENOM" id="CLU_036532_0_0_1"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="78"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="363" mass="40657" checksum="74992BB97685E5C0" modified="2015-03-04" version="1">MSKEAETKVAASSFSNEIPISKFLINHSIKLESLLNGESYSYFSDVPTSTSKTINETIINSSFSYSSCDLDGDLSSPAYVLGVDEAGRGPVLGPMVYGAFYLPVSLSDFLLRKTHQFDDSKNLTHTVRSDLMRKVCTEGTDLYEHCGWAVEVMSARDISSNMMKPGVSYNLNAQAMDATIGLINQIHNKGVNLKEIYIDTIGKPETYQKKLEAIFPNIKITVSKKADSLFPCVSAASVCAKVTRDAALELLYENYLKEKELGEDFVQSEIAEDSWGSGYPSDVKCSTWLRKNMHPLFGWGSECRFSWATAKDMLDQRDQAVKVDWPVDEDEARHLTQYFSSKNDKDTDELYNWFGRPVNSSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVU1</accession>
    <name>A0A0B1NVU1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005166">
        <property type="protein sequence ID" value="KHJ30093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVU1"/>
    <dbReference type="STRING" id="52586.A0A0B1NVU1"/>
    <dbReference type="HOGENOM" id="CLU_316467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058738" evidence="2">
        <location>
            <begin position="29"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="749" mass="84514" checksum="C8B86C58A547523B" modified="2015-03-04" version="1">MAKSKFLLGISVLLSLVFFLVSFPEFQSIPSTVVPRSMTLGTDKALPPHQESPAVESNLRIMAENISSSNSERQDKADFRRRGEVEPMGESSSDSDVFGEMAEKSDMDYFAFTAENLFESQHAFWYANWTLTRQKDADWKEIGEWKLFAIDYFQTRNLECGSFWIDCKDMPSLSEIQALYPGDRVLARRVYFTSECYLIIRNYLKAVQTILDEMNLSLYGLIPEIVHTFTSQPNPSAQAACAMIGAVVNTLVNVGVTAVTGMMSSTVTSFYDKMKGNVARATHDAEVASRWYTNIMTTNWIPNSVVNWLRAQDQFNAWGEITPEKTAELKSLSERVAKLFGTVPSSGYPPHSHPELVPGLQKTKDAYRKAKKNFPWIKPVTQMPVNLRVGLRFGLQNLLRDQMRLRLGSSTLGGTGVCARFNGGDLDYSAENINQVQGHLASVFPQILESLSYLYEGIYNGSLQEEGHPSWLAVSMLNHNWAEETSYLQRLRHGGPMKREIMRAFTLNIASQISASDGSYMKCTHKSWAARKCDQMARAKPTDQAALGYFCPRAETDPGLICQVGRWSSSSQYSHEMPWPALLKIEGFAANRFGLTRLNLLNAAYDHYELYGNDLTVEWDSWFLGPLSALTGLTMPVCKHDDLAMKDNTVHGPGHKTKGKNSWAVPNVCGINGSETEKFLFELGFLEGTPAWNSRSKYEHWAGGGTNELYSDRLVRANRDMFKTNPFMRYTTMCHQHIRFAEHRDYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWC8</accession>
    <name>A0A0B1NWC8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g4919</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWC8"/>
    <dbReference type="STRING" id="52586.A0A0B1NWC8"/>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="89"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="35165" checksum="357DE241634D4600" modified="2015-03-04" version="1">MLARSYLRFTRHVSVSAKRHLSSSSPDVLTPVRLNVAGSIATVVAIGSAAWYYHLFGEPAWAMTPAEEGLHPIKYPWEHEKWHKTFDHQALRRGFQVYREVCSSCHSLSRVPYRSLVGVTHTVDEAKALAEENEYDTEPNDQGEIEKRPGKLSDYLPSPYKNDEAARAANNGALPPDLSLIVKARHGGCNYIYSLLTGYPDEPPAGVKVQDGLNFNPYFPGTGIGMARVLYNDLVDYEDGTPATTSQMAKDVVEFLNWAAEPEMDVRKKMGVKVILISTVLFALSIWVKRYKWAPIKTRKIVYAPPKVNAGGGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXK1</accession>
    <name>A0A0B1NXK1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003243">
        <property type="protein sequence ID" value="KHJ31122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXK1"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="44551" checksum="120BDDFA15BD138B" modified="2015-03-04" version="1">MLQDNLKSTIAQFAASDADAKAYIPRLITSTTTHTERVEPREVNKLAPVAVPCIFSITNSGSKVQISINPKLPPKPIANESYWSTVVRNGFKKTKTATIPASQQKTSTQPRSSGHQLDHRPVNNKMPIPMQQATRPQDKRLIIRLTDGHEWRKLSPADICEIIINKLAISPSAIGTIKPVRSGFALSPCTNEAREALLNAAIRLSPFGAKLESATNWTSVLILTVPKSLHTLNGHIEVTKELLSQEIERVTKMCPSFLKLYGRNFSEAPHRTWMAFFAKAPRSGFRVFDESGAMRTFKKQQSPEFCKRCNGYHPSKNCSRALSCGNCGSTIHSEALCMTQTRCKNCGGPHRSDSKKCLARLTRFGLPSKEQLKTYREAGEREYQAILRANAAEKMATTAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXP4</accession>
    <name>A0A0B1NXP4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5723</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003680">
        <property type="protein sequence ID" value="KHJ30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXP4"/>
    <dbReference type="STRING" id="52586.A0A0B1NXP4"/>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="170"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="382"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="484" mass="56237" checksum="E025ADAAB5FBA1A5" modified="2015-03-04" version="1">MTSFRGLRQNSVKYLVAHRLCRPNILSLNRFHSFKLFGDYNFSRYFSTETHIIEVDQKIYATDSWTNVPRSILSSIPCRLHLQPDHPISLTRAVIESCFPSPSFKYYNNIPPVVSTYQNFDSLGFPPDHPGRSRSDTYYVNNSTVLRTHSSAHQADLFRANSSRGYLVSADVYRRDAIDKNHYPIFHQMEGGRTWDRKDGDITNEVSKDINLLPKHNLKVMDPDHPMHPIRNPLQTVHKIYEVEAITAHMKRSLENVIFEIFTRAKKATVSLNHEYHEKQLELRWVEAYFPFTSPSWELEVYWQDEWLEVLGCGIVKQSILNEAKVPSQIGWAFGIGLERIAMLLFGIPDIRLFWSKDSRFLDQFKGLSANLDNFKRFVPFSKYPGTYKDVSFWINDISNSNNMGQAAKFCENDVMQIVRDVAGDTVESVRKVDAFYHPKTGRTSWCYRVNYRSLEKTLTSIEANMLHEAVKKELVNKLSVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXV2</accession>
    <name>A0A0B1NXV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003121">
        <property type="protein sequence ID" value="KHJ31212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXV2"/>
    <dbReference type="STRING" id="52586.A0A0B1NXV2"/>
    <dbReference type="HOGENOM" id="CLU_044612_0_0_1"/>
    <dbReference type="OMA" id="SFETMWR"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="385" mass="45288" checksum="5FC955ABD776B83B" modified="2015-03-04" version="1">MQNFIYTVIILAFLYRLINSIKRKKPKKPWQELLKKSTLEMRAIPNKRLVLMFGIENSFTTSSPHVHRRFLRSTIKKLESIAKSDWKKATEFVCQEVEERRYNAKVLGSLKLSSLVQCLTFRFIMYEFFSSVQPPRDTTIEKLTKKINSLWIKSKSFEIEKLEVLETEKKEILQLLSETMSEKVEEGNKNPFNIILPAYETLWRVVSHCFLETVFRASPEERLVYYRIARRFIHNPSLNTLNENGFEQINMNMIVKETLRLYPPTRRIYRLFDGMKDCVDVESLQRDHVIFGPNANKFQPRRWKNIEQEKLEQYLPFGYGKFKCPARNNVASMMIAILSSTLILKMGGNCTISKNLGKDPIPSERNSFDDIELTIINDENFKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYD0</accession>
    <name>A0A0B1NYD0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative myb-like dna-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003384">
        <property type="protein sequence ID" value="KHJ30983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYD0"/>
    <dbReference type="STRING" id="52586.A0A0B1NYD0"/>
    <dbReference type="HOGENOM" id="CLU_001420_0_0_1"/>
    <dbReference type="OMA" id="RITRECT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="831"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1258" mass="142112" checksum="D3B01E5BA0DDD606" modified="2015-03-04" version="1">MNVRAFRSRYQQGYDSKESLQSSKELSPGRYNDIGDNFRGGTNRERRRSNPDTRTNQLTSNTKRELFRESLCRDLSRDFSREPPRGPKGVPDAPTGPRASSYGDFRSDFSFRGDIRSERGRGRSHGWRDDSRDRGWDPERDYRDRRDERFSTTFRDDRSRDRWGSRDTYSSSRRPLSPQGRGRSPSYSQRDIREPAISDLERTKRVSRDSSLSTGFLSSDIIQPFARTFGKVRGARGRARTGNYDEYHRITGPNRSPADTGWNRRTQPSATPPPPVPAFGSTSNSIPIGTYSSTGIVATLNGSAASIAVPTAPRSERRHNKITTPTSTQTFSEISRRNGVDKQLGNPTSSVNLTSSTSPSISKFDQNKSDYEITKKGEKEISLVQDSNRSSHLISDKILASTHEAFSHHLAARSNTSSHKRHPIIAKGPPVKLDTLLEDAGNTSDSDSGDDFGDEYFEKEISRVKEEISKISLVNPLLPRCEPEVLFLNAFIESDIWNIIETTEFSTLNKCQESKLEKEIQDETSKLLTAVNSVKSKAQIKGLKPNLVTTLELPSAKLLAPENFSPNTTFEYQNKKIELVPATLSHNSNSSEKHSIKDLELHVHRPKRSATKQLDSSTDDLSDAENAAILESVRKRMKTPPITSLPRFKYKPWYEDEVFLKSLEPSALIGVRIYHHLAEVTSQKKRDQEKEKRRWASRYYRYRRFTDRSNDPAAIRSRERFLKSQAKSAAEATAPKSVLASANSKPEGSRRVGSRFATEHELQRVLLQSEKEAKESKDKQDRITRECTATAKEAIIPDMLWDDKEREAIHFEDRSGLISFERSFAILEFGEPIDNFTKEESSLFEKAYFEFPKQWGKIAETLPTRDYKSCIQHYYLVKHPSSLKKKLKDQSKKRKGRQSKVKKEKIVPLINDLSSIRDEEEIPDGEADARSRRPRRAAAPTFNSDLKDQQNEFEATNLALSLAKKPSGNSSSEQNTETLSDPASHSFPSSPHSLPVPLQPSLPIVTATKRKAKISRDKPTKQVKSSQSSVAPPEYQKADSPVTTLSQEYKMQQKSEISSKDCTETENLILKPDSNISYVTPVEQATSLIATNTSNFEKNQPVKTPEMTKISITSKSEPSLTQKNAQQTSSYWSVQEQDIFSTLLGYYGTNWHAISKYMATKTHIMVKNHYQRQVDSGKMKEWEIIAKAADEKLKKGEPTGPIPSPAAMPTRKRIEIPSTSLTRSSYPTDVDEDILNPLPISSSHVIISSLQLNHLHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYH3</accession>
    <name>A0A0B1NYH3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mt-a70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002897">
        <property type="protein sequence ID" value="KHJ31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYH3"/>
    <dbReference type="HOGENOM" id="CLU_027091_4_0_1"/>
    <dbReference type="OMA" id="EEWVWIK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="390" mass="45160" checksum="25D5FE98658DB443" modified="2015-03-04" version="1">MESHILHQNSTFTVFLVDIPRSIELVQGFQHSSSLRIVSTPPLEVPFLTPEPKSLKARIKVLENKESQSIKDLILKRYVEFALEEIRHNIDRRKWCLDRVTNKAVISDENVKISRDRTCPSQDYHTFKELLSLEGKIFGLHNSNVDQHISSNCLIQNDKSISMVISLAGRNYLLPPLSTCLLGTIQNTIGIFNKKNIKIPQFSIITADPPWPNRSAKRNGDYLISNKYSEIENLLLSIPIRHHLTDNGIVAIWVTNKLKFQSLVLKIFKQWNINVIEEWIWLKTTVLGEPIFPITSLWRKPYELLLVGRKVAKAESIDINLKKRVLVGVPDLHSRKPNLKELLEKVFGFEHNNYMGLEIFARNLTTGWWSWGCEALMFQEERFWNNVDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ78</accession>
    <name>A0A0B1NZ78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gyf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002643">
        <property type="protein sequence ID" value="KHJ31702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NZ78"/>
    <dbReference type="HOGENOM" id="CLU_001585_1_0_1"/>
    <dbReference type="OMA" id="GNTQGPW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="719"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1444" mass="157574" checksum="0FC699C5F6683D2A" modified="2015-03-04" version="1">MPSQIPTSFAAAAGQGPNRDFRNGGKNEGRGSGDWVRKEVKPAINGTLTLRRPPTSLIGQSPGQEELQIQSESSGSQQLIYEHSQELRYSKQELLEIFKFQQQSRVTDESHVSRLFADGWAPNEPQGSSNRAGWGKNSDGKDCSAPEICWDFNGSTQPVGLVEMSEEEKRLFKADINSPFKPLSQNLKDSTVNGHKSSFSHGHGSNNLNHPSPISGRPNTRRQQANDPSNSGIASPNTASRFSRDDQSPFYTRKFDYKDNTDERSDDNKLGLGSSGLNRPNNFGSKLSPGQLSAWPSSSNTALSPMGAFGNFSHSNTSNSISGEKKPVNLKTESRFFQPISKDNLEDLTKPLEKSWRPRQRTDTDPFADDTLDGNIVTTVDDNTQLNRLIGDLGISKTGNTANYIIPENHVFQDDSTHEQDHQIPKSINAVDEQVEPPSPSDTNPYRSPSGLQVDRKQLDTDAYDSEAHLPDRVLGLGNTLENSQSSFGTIPRGFSNSVFDIVDRSQTSSAMRSRLANQAGALPSLGAIGSLGGWPVTSGSPVGITDHDSRSGFPSAFGNSFFGAMGETQSPGHNGLTSMFGPPSNSIPATVARGSKLGSLFPASMQAQMQTTEIESSGENETRQNIAFGTLARNSFIPSRDTDSPVRVNRHVCEDPFSLVENSRSTVNLPTPEISHVPLVSTFNNPLQNNSQPQISSESVLNQQLPTNQQRIMVMPDRMRWLYLDPQAQVQGPFSGLEMHDWYKASFFTPNLSVKKLEDAEFEPLGQLIRRIGNSREPFLVPQIGIPHGKPSTQLGSSFTPPAAGHGPGLAQSGAVQPPFANSFPSFGTTLTAEQQNNLERRKQEEQYLMARQREFLAQQQVNIKQMQLGGIPSVLHHHSSLQNIQSQPSFGGISSPISLPPQSHLANVPGFFDGLARQISTNSLPGEFYRDEDPSRLTIRERHGQKVGSAFGQPDMQVQTQNIDDIDFTARLHEFTNLRDQTEIDEAALINSSQPSTDSVPTTKKPQLEYEEQILLEQAEGSDRQPNEPNIMAQRTQQNVSTNQVNSTPIQKESPWAKVNTNIPMPLPPPQTISILPTPTFQKDHHNTTEILNFEKKPQSKTPEFPTAHSIAPWVKDPIQLPKPVSLKEMTEAEAKKAAKAEEIAAANRRANIEQEARSSTAQPAAAPPPGLPSTAIWGSSTSPHSAPVKSAWANSVTKAQPSSNKQKTLADIQKEEELRKQKLITATASQSSVGSHGSKRYADLASKTTPNSSPVGGPTWVTVGAGGKVRVPTGPATSVQASTARSSSVQNITLPNRTNSKPIAQSSRSNTVSETININTAHDELTRWAKTTLEKHLNPGINVNEFVAMLNTFPSEESIIADSIYSQSQTMNGRDFAHEFIRRRNNAERGVVEPVSNGSGSNFSTNFDKTGGWNEVAKKGPPKEEPAAGFKFVPNKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZD8</accession>
    <name>A0A0B1NZD8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pre-mrna-splicing factor 38b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004326">
        <property type="protein sequence ID" value="KHJ30395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZD8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZD8"/>
    <dbReference type="HOGENOM" id="CLU_038073_1_0_1"/>
    <dbReference type="OMA" id="ETDNHNT"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="391" mass="45037" checksum="E0C85D6A24E814B7" modified="2015-03-04" version="1">MTNFDFLTDEYVAQLLAKDAKESSIRYSAIGLEAYASSKPPANKPKPNTRFLRNIIKDTDSHNSALLAKEGAEARERLKSLQNAASERCKINRKSIRKNQLCEIEAILGGISAKRKRRRESSTLDEQCHLHDEKGEHHVKKSKSSRKENDKTTEAETKDKIKVVKKDRRFKGVIDTLRERERQGESSKSRRKSQSKSRSKSPLKSKPENHKEFSSDKRKSKSAECLHSHRRNRDQSSQLKKCPEFRAQGGENDKVLEKNIEIGTNSDPLDEFIGPSPPVPVIEVRKRGRGNTSAASGIDSRFSAFYNPHVDILIENDDDDKNWSQALEAFRDWKKFKEKGIERLRCAGFTEEEIQRLERGGQKREQDVKWSKPGERREWDRGKKLENYDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS7</accession>
    <name>A0A0B1NZS7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01004022">
        <property type="protein sequence ID" value="KHJ30545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZS7"/>
    <dbReference type="HOGENOM" id="CLU_1434982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="22828" checksum="7391FE2F0FA0D576" modified="2015-03-04" version="1">MSRSRICLPRYLNATKSKNNVFFLSTKSKIRQTTVANCYYKDYPLLFRPFTCKPEHDRDNLQKSHELNNQSSQTITRANSVTPANLSVEQYHALADTYLSDLEEKFNELQDKDELIDVEFSAGVLTLTLPPKGTYVLNKQPPNKQIWLASPISGPKRYDYVHFAKDDKHGAASGEWVYLRDGSTLSNLLMEECQINMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZW2</accession>
    <name>A0A0B1NZW2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01005072">
        <property type="protein sequence ID" value="KHJ30119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZW2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZW2"/>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="83"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="45337" checksum="4CD130615A457718" modified="2015-03-04" version="1">MFSSSLRTNGIVRLRSIHISSSFISRRAVTTNAASSHAQAVPKENDKPFQVTLSNESFETYEFEEPSFTLETTKNELKEMLYNMLTVRRMELAADRLYKEKKIRGFCHLSTGQEAVAVGIEHALRPGDDVITAYRCHGFAYMRGATVKSVIGELLGRREGIAYGKGGSMHMFTKGFYGGNGIVGAQVPVGAGLAFAHKYKGNSNCTVSLYGDGASNQGQVFEAFNMAKLWNLPVLFGCENNKYGMGTSIQRSSALTEFYKRGQYIPGIKVNGMNVLAVKAAVAHGRAWAAAGNGPIVYEYVTYRYGGHSMSDPGTTYRTREEIQLMRSTQDPIAGLKHKLIEWNAFSETQIKEIEMEVREAVDREVSEAEKMEAPEAIPKILFEDIYVRGSEPLFMRGRTVDENYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX1</accession>
    <name>A0A0B1NZX1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative small nucleolar ribonucleoprotein complex subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002823">
        <property type="protein sequence ID" value="KHJ31533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX1"/>
    <dbReference type="HOGENOM" id="CLU_021102_2_1_1"/>
    <dbReference type="OMA" id="ATYQVVH"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="8">
        <location>
            <begin position="384"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="59675" checksum="FBC81DA87CF7E479" modified="2015-03-04" version="1">MAHPVQKFQITKGPAGPSPVTPEQRYWKEFRSSQNIPFQSPVTHISFTPPSADALLQTSNDYFVASSGTRLQMYSIRTCKLVKTISRFSDIVHGGEIRRDGRLIVAGDDTGKIQVFDVQSRAILRTWEEHKQPVWTAKFSPTVLTSIMSTSDDRTVRLWDLPTGESTVVFSGHSDYVRCGSFMSGNMSDLIITGSYDSTVRLWDPRTSGKARMTFKHTAPVEDVVSMPSGTQITAATGNQISVLDIIAGKPLQILKNHQKTVTSLCLASNGSRLVSGGLDGHVKVFETTGWNNVYGSKYSSPILAVSVVNAGLHREDRHIIVGLQSGIMSIKTRLSGHEKVKQRDRDKEMQALIEGSLEKYDKKSKKRKREIDKEVKEKYLASKEAEFIIEGQEQRRRKSESAWERDLRQGKYAKALDQILVKKMPSITVLSVLQHLRHRSALRTALEGRDEITLRPIFKWVSNRLIDPRYVSICTDVSLLLLDIYSHHVAHSIELEKMIRALHHRARLEVTWAQQACQISGMLKLLMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZY8</accession>
    <name>A0A0B1NZY8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZY8"/>
    <dbReference type="HOGENOM" id="CLU_1587720_0_0_1"/>
    <dbReference type="OMA" id="CIYQISI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="168" mass="15368" checksum="4F84734B93B8A5F0" modified="2015-03-04" version="1">MAGRAVSLGFGVIDDTTLVGCIEGVIITNAEELVATKRGTLIGIVDEGDSIDKGRSLKAVGITSTGRAEVEICSGTIEGLSFSGLLEGSATITSAGISGDFWGLSSSLLFGGVVGAGGGGSGEVVGCGGGGGGGGGGGEGGGEGGEGGEGGGGGGEGGGGGEVVVGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P039</accession>
    <name>A0A0B1P039_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004628">
        <property type="protein sequence ID" value="KHJ30261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P039"/>
    <dbReference type="HOGENOM" id="CLU_687345_0_0_1"/>
    <dbReference type="OrthoDB" id="3529015at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45850" checksum="86A4FA606FC9F3EF" modified="2015-03-04" version="1">MKYIRWVESHLFATADEKTPKHVEEKCAEYIVEHESKAHVRDSFLPIASAFSSANFAEPCVQPVAKEDESQSNIPLMSRPRPIAHNGTEKSFFSRGTIPTENINLPTRIHSKYRPSYSKSEETPENQPEEKTTVQKVPGRQDLLEIIKELYPCMIKYIDIRDGSQPKYSTCSTKGSYDTLRKQTLTMNTIPAYANLPTPPMSPFESLGRHTAYEINPIKTSDSIEEPEFHQIRSFLIKFIDRKVNNIPEDLKLRIMECYSISSADFTPETATNLEEHTGNFEKCIRTLIKVFNSPIAEKWFEIVEAEELEENNAKVEQSSTTLLGKNTERFAKSITDGYCSDSDLVRCRTKFAKIDSPTMFSMTNFTSTKKLSSFNLKKTYEKKFRTDRNSIRRAVSGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P044</accession>
    <name>A0A0B1P044_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002738">
        <property type="protein sequence ID" value="KHJ31608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P044"/>
    <dbReference type="STRING" id="52586.A0A0B1P044"/>
    <dbReference type="HOGENOM" id="CLU_041481_0_3_1"/>
    <dbReference type="OMA" id="ECTATER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="309" mass="34285" checksum="33C03F480665DD81" modified="2015-03-04" version="1">MMASLKYARSPTIKRILHEAAELAQSPSPDFHAAPVNDADLFDWHFTIRGPPSSVFESGIYHGRILLPPTYPLRPPSFRFLNSSGRFEVNREICLSISGHHEETWMPAWGVRTALVALRSFMETDPKGQLGGLECTATEREKFARESVSWVCSVCQKKNEDILKDSLIFYKDMGTDLNSIMSTPENHVTTVRTSVETERNVVENGIVSDTKAQETDDKHFNESLTKNTSKLPSYTLSGSSQTKLAALSSPNKGLSSDSNTQIIQPSQTIPVISMNQGSPLWIDRAIATIIICLVLMVMKVLLGLGRNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C2</accession>
    <name>A0A0B1P0C2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002349">
        <property type="protein sequence ID" value="KHJ32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0C2"/>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="321"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="377" mass="40182" checksum="79AB44F0F63DA116" modified="2015-03-04" version="1">MTPNLLELNFNIDKCSEFLRLLIPPFSSKMISRNGFTFGRLARPLRSPAKPASTFFWTRLLSSLAVLEQKDGKLNQNALRAITAAQQLGGPVTGIVAGGNIQELAKEISEIQGIQKILVVDNPAYEKGLPEFFAPLLIENIKKGGYSHVFAGHTAFGKSVMPRVAALLDVSQISDITAIINENTFVRPIYAGNIISTMESLDKVKIITVRGTAFQPAETQGGSASIEAGTDPKVNFPIEWLSENLSITDRPNLSSAGRVVSGGRGLKSKEGFDRVILPLADALGAAIGASRAAVDSGYADNSLQVGQTGKVVAPQLYFCIGISGAIQHLAGMKDSKIIAAINKDPGAPIFQVADVGLVGDLFEKVPELTNKLKQQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0E6</accession>
    <name>A0A0B1P0E6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004393">
        <property type="protein sequence ID" value="KHJ30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0E6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0E6"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_2_1"/>
    <dbReference type="OMA" id="YSMAEMC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="525" mass="57704" checksum="357ABA710DC7C64B" modified="2015-03-04" version="1">MTDSDDTKLRDYAEDRALEHLGYQPQLKRSFGRWGMIGFSFSIVTCWSALGGVLVTGVNAGGPPVMIWGWVAVSLVSLCVAYSMAEMCSEYPLAGGQYSWVYILSPKSVRRQLSYLTGWLMIIGILAMGATNSFIGANFILGQANLLNPTYVIERWHTVLVAYFITLFATFINMWGAMILDRVSKGLLIFNVTAFVVIVVTILATNSHKQSASFVFQDFQNFTGFSPLMAGIIGILQPAFGMCCYDAPAHMCEEIKDASKKAPQAMVLSVYIGAVTGFIFLVSVCFCIGDIETVANTPTMVPLIQIFFDSTGSKFTSCLLASFMTIIILGAANALMAEGARSLYAFSRDKGLPFSSYISEVNPKVQIPVTAIIIATVVQMMFNSIYLGTITGFNTVIAIATEGFYLSYAMPILVRLLSHVNDNYREFKGPWALKPYISILVNAVGLTYLLFACVTFNFPSLYPVTTSNMNYTSAAVGIIMFIAFITWFTTARRTFSGPNIDGIDNLFKFKSETGELMGPEKMDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J0</accession>
    <name>A0A0B1P0J0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative alternative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004263">
        <property type="protein sequence ID" value="KHJ30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J0"/>
    <dbReference type="HOGENOM" id="CLU_778889_0_0_1"/>
    <dbReference type="OMA" id="ADITICP"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="39843" checksum="99FEAF330CC88ACD" modified="2015-03-04" version="1">MGPVPSFSSKWKEVLGFGDGFSRSNKTRSMTISQPRPNFYQITTDAPYTPTSPVASEISNKKLSYPLIPRDIIFVNHKNEILVSACQSPTSSASIEASLPSSLIGKPLFRITLGADSLNDTGRPDVILHASADKASTAVCFSKIHFSTPVTEMTLCPPPKKPISANFSNDDIATQSIKSSRFNAYENRPKHAKSKSVCTGTYSISSNTPLASCNPYDCSLPRFRTERLFQVVDPTTSSYKYVFFYGYEAFEWRRSEPSIHHLNRLRQETTKDEDYRSNGMKLVRALTEEVLVVFARINNSLLPRETKSNSISGIMRFSRSECVTSCAEDFDIFVVVSLVSIIEKERRERRHSLACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S7</accession>
    <name>A0A0B1P0S7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002568">
        <property type="protein sequence ID" value="KHJ31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S7"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S7"/>
    <dbReference type="HOGENOM" id="CLU_279011_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="260"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1131" mass="126739" checksum="D87DB82DB21A6134" modified="2015-03-04" version="1">MKTSTNFRNNSQCTRLPIPDTSYTDQVRKRLQTYGLTPPIIESHTLQKQRCLKQLASKTLPIEKYIYLSGLRNANTHLFYRLLIDNFTLITPLVYTPVVGEACLRWSEIYRFPEGLYISYKDRGSIIEVLRNWRQPKVEITVVTDGSRILGLGDLGVNGMGIPVGKLALYTGCAGISPDKTLPLMLDFGTNNEGLLNNKLYMGARMKRISEKEELEFMDELMVALNTVWPGIIVQFEDFKNPFPALEKYGPKYSCFNDDVQGTGAVILGGIINALKMTSIPIKDQRAVFMGAGSAGVGVAKQIVAYFMKCGLTEEEARLKFWLVDTKGLVTDDRGDMLAPHKKYFSRPDNNGHQFKTLAEVVDYVKPTILMGLSTTRGAFTEVIIRKMALLNKKPIIMPLSNPSDKSECTFEEAVKWTDGRVIFASGSPFLPFLYNGKMMYPSQGNNMYVFPGIGLGSILCKAMLINEEMIYTSATALSTTLSDEEFADGKLYPNIDRIREVSVVVAREVIREAQRHGIDREDSIRNLTNNQLDEFIRGRMYDPNLVEKTSSDNNCIADSKLSNTTLKSRLSKSSPSRGAGVNAQYALHIWDSQEDSHNPSLQDPHPSRRVSVVFVSTSLVSQHLFSRSPHDWLREYRVKGSILSQRTSDESKLLAQMVRCWLDFLEVIRGPCILDVLHTGHVLWTLARAGTIKLQTYTYILNAGDSFFLSGAKLEPATNWTSMIIPTVLKSIHKIQGEIEVGSSMLIDEVERVCSVRPAHVKLYGGNKTEAQHRTWMAYFSKAPRAGFRIFDESGIARPFKKQQTLEFCKRCNGHHPNKNCSRAPSCGNCGSTNHSEDLSMAATKCRNCAGPHRSDSHKFLARPTRSGVPTKEQMKTFRQVGKREYQAVLRARAAEESATAAENINIDLTISQETEIDGNIDNIQAKDPKRITSVQKHPPSPTGDHCWVEVNDILFLNFYKALHDPTTVRPLLDWVPTSKSIVIGDFNSVYWAWKPSANSCYRQGEEIEKWAEEYNLTCLIVGEPTYRAGNTLDLAFTNISETMAWVCTEECMTSVHLPIFCFAPNHKASTTISPTSNGKLQVSKANLPQFALVVTQWLPSLRSTGTIEEIDEFAEDIKMALENPLKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P182</accession>
    <name>A0A0B1P182_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003936">
        <property type="protein sequence ID" value="KHJ30584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P182"/>
    <dbReference type="STRING" id="52586.A0A0B1P182"/>
    <dbReference type="HOGENOM" id="CLU_055871_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="105"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="30466" checksum="EFD89D520206FBA9" modified="2015-03-04" version="1">MGIIFDNIENMLIHKSTGITHAVIRRFGHAFLMLQQNKVQIQNNNIIEKHFKYLTEGDLNRLHRRFGHPSVACLHKILQEAGHNDPDNFKTLTNISAHCKHCQLNGPAPFRFKFKLKDDKNFNHTILVDIMYLEGNVLTLHVIDEATRYQAARFLKDVSSQSIWQALRLCWIDVYVGPPDLIIHEAGTNFTAKDFQQNAVSLAIRTKCVPVEAAHSIGLVERYHGPLRRAYSIISSELDTIEKSLKLQMAVKAINDTAGPNGLVPTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1J2</accession>
    <name>A0A0B1P1J2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rna-rbd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002030">
        <property type="protein sequence ID" value="KHJ32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1J2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1J2"/>
    <dbReference type="HOGENOM" id="CLU_058466_1_0_1"/>
    <dbReference type="OMA" id="VVANFHN"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="163"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="346" mass="38563" checksum="CFF5EAB6E86A6AC3" modified="2015-03-04" version="1">MAPNKPTVDFNAIVQAERRRRKNESVAQKMFDKARRQNTSRRGGGHHKHGTVPSLASRVSEIGISKRTHSASNRPRRSGGFGARSDNPEDDWTHDLHGLNNPSIGSSNSNGEDSRVRANLATRKLISENHLISSPTFQTQFNIVGNAKPTESLSIRGLAGPYTVIVKNLATGTTAADIESAMAPVGGLILSCRLISERPRVIAEVILETKEGADNIVETFNNQSADGNILHVYHKVGPFLNPSPRPPVLTRNLVAPSRPRADYINDQTEDSRSYAETDFNKSRGRNSYHYKDNNREDVMDGSYGFSDRMEIDDREDKYKRRGLYSDNLIGNRYGRRSRGDEGRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1J9</accession>
    <name>A0A0B1P1J9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="JNVN01002326">
        <property type="protein sequence ID" value="KHJ32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1J9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1J9"/>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="29091" checksum="85F1FFD4E0427F1F" modified="2015-03-04" version="1">MTIFRPCLDLHLGKVKQIVGGTLNSESSDLKTNYVSHFPASHYARLYRLNNLRGSHIIMLGPGNESAAKEALSEWPGNLQIGGGITNLNAKNWIEWGAEKVIVTSFLFPSAKFSQERLNTILESLGNNKEKLVIDLSCRRRDNTWYVAMNKWQTLTDMEISEATIKYLEPFCSEFLIHAADNEGLQQGIDVLLVQKLTKWCNIPITYAGGGRNMQDLEMVKSLSYGRIDLTIGSALDIFGGQGITFDECVEWNRQQESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1R0</accession>
    <name>A0A0B1P1R0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003602">
        <property type="protein sequence ID" value="KHJ30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1R0"/>
    <dbReference type="HOGENOM" id="CLU_1278463_0_0_1"/>
    <dbReference type="OMA" id="GIGHIHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="216" mass="21477" checksum="175447168ADADBD4" modified="2015-03-04" version="1">MGSLTLSDILTIVFAAILIATVVAIAFDIFITIAIAIVFIIAVDILNAVTVAITVDILIAIGATNAVAVAVSITVDILNTVTVVTIAIAATNAVAVAVAVAVAVSITVDILNTVTVVTIAITATNAVAAVAVAVSITVYILNTVTVVSVAIAVDILNAVAVAVAIAVAIAVAVAVAVAINNFIAVGVVIIIITILITTIRGSGLRGSVRICCSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P263</accession>
    <name>A0A0B1P263_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chromo domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001836">
        <property type="protein sequence ID" value="KHJ32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P263"/>
    <dbReference type="STRING" id="52586.A0A0B1P263"/>
    <dbReference type="HOGENOM" id="CLU_573621_0_0_1"/>
    <dbReference type="OMA" id="PENILNW"/>
    <dbReference type="OrthoDB" id="3543857at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="381"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="527" mass="60042" checksum="BFE951B6CB4806BC" modified="2015-03-04" version="1">MVILNHVSRPNPMSSMRSTLELHFDFVVTEKSIYTPGSGPEVPDPTPMAEHDRDGFIISELSIDRANFTYIVTWRDKPHLLVSVRPQKIRDYVSARSYEEWNTKKMQEELNGPLPENLRTDEQTELKPKSQIVRKRRKKRKTIDAIECTQNSQVTVKIANNFGQSISLSPGQASFISPSSQDLNIDNEIYNNEARKQFAPKKSKTGGSFTAEEKSSMSLSIPLTEEETVGELQRSYFDSQARSFSAEQPPLNGENKQTILALPSDTSAVRELTLAKLRNTRPISNTATPVLSKTTEKKLVESIISHEQKAPEVNLFSSNVNVTLKAQRKDQKNLAKKSQNKRSRQSFTSYIESKPTPLRPRKKTINSVPRLENESDSDVEYVVEDIKDEKWEQDRKGNGVLFYLVKWKGIPSYTWEPEENISSDVLTEYTVQKLSRSKNRSRRSLDRSSLSFDTEDKKEATKGKQVEYINHEGIELDKIKTDRKAKQKAMAINMFEPDIPRKKGSGIPGDLGDEDEPFQVPSGRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P289</accession>
    <name>A0A0B1P289_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative s-adenosyl-l-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002878">
        <property type="protein sequence ID" value="KHJ31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P289"/>
    <dbReference type="STRING" id="52586.A0A0B1P289"/>
    <dbReference type="HOGENOM" id="CLU_010595_1_0_1"/>
    <dbReference type="OMA" id="FINTHIV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="36003" checksum="AF925FF4A746DE3A" modified="2015-03-04" version="1">MPAGNLPRRSLPQASHDDDLDSTLGDDTGSEADYCSVTDSVYDFPVENGRTYHARERERMELVNDAINLIFEGKPFFAPVRNPHKIVDMGTGTGAWAIDVGDQFPEAHVVGIDLSPIQPKWVAPNVEFRVDDIDQPWAFSRSISLIHSRLMSGHSIRNWPSYFRKCYAHLSPGGWVEAQEVTLTPRCASSGPFLSDSYILEWHKIFHHGMRRAGYDLNVSADDIAAAMEDAGFINVHVQRKIMPLGPWCPERHLREAGRLVSESLNHGIGGISVAVFTRILGWQVIDLELFLRNVRREIRSRSLHAFWPFCVIYGQKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H3</accession>
    <name>A0A0B1P2H3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002038">
        <property type="protein sequence ID" value="KHJ32493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2H3"/>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="121"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="25978" checksum="71082DD1B0B7009B" modified="2015-03-04" version="1">MNRSPEGNDCANLLGYPRHAEHTGRLHRHRVKVKISTFPALKMECSGADVGLPYGWEVRHSNSKNLPYYFSESLKQSRWEPPPGTDHNKLKAYIALHHGVNAIPDSNRPGTAGLSSNLTNGGKIRAIHLLVKHRDSRRPSSWREAEITRSKEDALNIMLAHEERIRCGVKTLGELAMTESDCNSAKKQGDLGFFGRGDMQKEFEDAAFELKVGEMSQIIETASGLHLIQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Q2</accession>
    <name>A0A0B1P2Q2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002738">
        <property type="protein sequence ID" value="KHJ31610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Q2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Q2"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="220" mass="24539" checksum="F7F8920A61867EA8" modified="2015-03-04" version="1">MTNYPNGRRKAVEITVAISPLFGKIKPVNSGFALSPCSTKARETILNAGNGFFLSGAKLESVTNWALMIIPTVPTSIRKVQGKIEVSNSMLIDEVERVCSIRPAHVKLYGENKAEAPHRTWMTRSFKKHQSLELYRRCNGHHPSKNCSRAPSCGNCGSTNHTEDLCIAATKYRNCGGPHRSDSHRCLARPTRSGAPTKEQIQKFRQVGERESTRQCYRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2U3</accession>
    <name>A0A0B1P2U3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003380">
        <property type="protein sequence ID" value="KHJ30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2U3"/>
    <dbReference type="HOGENOM" id="CLU_031263_0_0_1"/>
    <dbReference type="OMA" id="IDEYSIH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="423" mass="48101" checksum="9F3B54C61BDCF0C9" modified="2015-03-04" version="1">MIFKTYNGNNYQGFSRELMSLNKMYSEENKYNGLPTESFTYKFSIFIDLASKSEIPQDALPTAFSTMLKGMALEYYYSCCQGSTLTISQLIRRFQEHFEGEEHRRNMLREWNKVNLRNMFHKNPSKEKGLVFHEMVQILRATQRGLDREYQTDSALRNKIISACSDIPACSSAILQQTHSISALCNNIYAALEYNETAIRAESSDPVASAYLTDRKFHERIQTSRQNSSHNNSSHSNALTSSNPKKCFVCRQVGCWSTNHSQQERTKARARFSKAVRAYVLEHDHSGDDENINDTEALILEIDEYSIHDDQFTSDLNCFYTSISKVTAQDAENHFQVLANQSTYHTLTQDNKTSDHFLVNNRYSSERFHGIMLDTGASYSSIAGFGQVQAYIAEFNACMDTSNTGNLCAKFGIGESKSIVLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P305</accession>
    <name>A0A0B1P305_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001899">
        <property type="protein sequence ID" value="KHJ32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P305"/>
    <dbReference type="STRING" id="52586.A0A0B1P305"/>
    <dbReference type="HOGENOM" id="CLU_012062_38_0_1"/>
    <dbReference type="OMA" id="IAACGEM"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="108" mass="11488" checksum="F8685D0D061B4EE4" modified="2015-03-04" version="1">MCQGGDFINGDGTGTTCIYGTKTFADENFLIKHSEAGILSMANAGPNDNGSQFFITAAPTPFLDGKHVVFGKVFEGLEVLHKMLNVKTGYRGKDVPNLDVIIAACGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3A2</accession>
    <name>A0A0B1P3A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cutinase g-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002915">
        <property type="protein sequence ID" value="KHJ31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3A2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3A2"/>
    <dbReference type="HOGENOM" id="CLU_030977_1_0_1"/>
    <dbReference type="OMA" id="PFFYYNP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="58981" checksum="7CDC9CDFCC619458" modified="2015-03-04" version="1">MSQSLQPFNMFSPEIPSNSVPFSQMYHNGYSGNAQLSSPYKKDQLLSSHIPPNLLIQSNIHDSDVYYYPSTPPLSASPSLSGSPSNYSALPTPVNTAIFGMQRIKDEIITDNSGGPNWLNYDSPPVTPAYVQSGMLIGNGNSHDLVSIQRPTNSPSASPLPSQLPTEPENDFCDPRKLTVCPGVHQASILEESEPLLNVNHLPPRESSEEQKHLVRTTTPRIFNSKDVTYLSMPQPIFHNLDQRTELDVGDNIFCGFPNYSIPDASFYLTTKRQRTDSGISMTNGPIINPCEFHELDESGSYSQFAVACPLSPPSSIPERDRKNAKRSKKLKKMASELPLQKDNNESDIQFKPESYSSESKNDDKNTKSTDTSSSGVSEKSKLSDLSKTQQVTRRGRKQSETEDLTKTFVCESCNRRFKRQEHLKRHYRSVHTQEKPFKCHECGKDFSRSDNLSQHARTHGNGSIVVGLLEEAEMSSNVSANCEHIGNLGSILFNVAAAAPGSETDRSSQCSSNGSSNSKDGQSRKKRRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3P8</accession>
    <name>A0A0B1P3P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002762">
        <property type="protein sequence ID" value="KHJ31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3P8"/>
    <dbReference type="HOGENOM" id="CLU_049841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="35835" checksum="3A6F04589E3A8899" modified="2015-03-04" version="1">MQSSFNSLTLSKILIIHKDLKTKPECLDELIREIQRLYRGLPRYRRTSDGKDFELRNKLLAACEEDSDCSMACMLPAKTFQALMAQLQTSISLSLKVQKSQQTAHYTVDGYEYNSFYTDRQYYGQKRSQTSSSSANNKEQPKTKFSKKACFVCSKEGCWSTRHSPEERMKSMVDFKSKTLRLTGRRYTRLEIRQFLNDFEGLEPVQEIPDNFSHFHVTQDDEESGDLEDFFRTGNFFTDSQTEITSEAYSDFFPTLRGNFDGYTTDVSLRDKSIGHLLTQSRPCPGSRYSSLKFEAILIDTGAAKISTAGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3S5</accession>
    <name>A0A0B1P3S5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g3054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01002413">
        <property type="protein sequence ID" value="KHJ32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3S5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3S5"/>
    <dbReference type="HOGENOM" id="CLU_051699_2_1_1"/>
    <dbReference type="OMA" id="ETNVGPY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="24163" checksum="E1B420654B5EF1A8" modified="2015-03-04" version="1">MIDDQAGKLCSKKRNEFQSRYFPPVSEWQTWIHPITHCTYDITLQLSSTLSNQDFERCFSLVESTSSDHYKNSITGWNPPFKRNEMRHQDMKYVLVTLRGKLQGFMSFMPSYEDGIPVLYCYEIHLSSELRGTGLARTLMQLLDSVAAKIPTVEKVMLTCFTQNTRAFKFYTKIGYGIDPSTPPIKQLRNGTKVGSDYMILSKRINHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3T1</accession>
    <name>A0A0B1P3T1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mannosylphosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003027">
        <property type="protein sequence ID" value="KHJ31284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3T1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3T1"/>
    <dbReference type="HOGENOM" id="CLU_052528_0_1_1"/>
    <dbReference type="OMA" id="ILGHYDT"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="276" mass="32608" checksum="43E111594FD0E423" modified="2015-03-04" version="1">MRVHQPLTIPLLTFVCVFVVHNFIRIYTAALPTHREVKLAIERQTQTEPKYFFEPGGSLELDHYDVRYFSGVVNPEEKLKSLQLLIRSYLTVFQKYKIETWIAHGTLLGWWWNGKILPWDWDLDTQVSISTLKWLATNLNMTIHDFRFIENVNDHETRQYLLDVNPYTKERSRGNGNNVIDARWIDTKNGLFIDITGLSEIKPGVLSCKNDHHYRVQDLYPLRDSIFEGVRAKIPYKFETILTEEYSKRALITTVYEGHHWAPEQREWVKDPARVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P405</accession>
    <name>A0A0B1P405_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P405"/>
    <dbReference type="STRING" id="52586.A0A0B1P405"/>
    <dbReference type="HOGENOM" id="CLU_136313_0_0_1"/>
    <dbReference type="OMA" id="VEVRWTN"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="106" mass="12102" checksum="314F6A9CC8AAB1AB" modified="2015-03-04" version="1">MSISDSFIPESHSQDELDSLPSSEISDDSFSENSSDAQEEWEASLHQLEMVLTMVIVPYAGKYFGRKFAFWSWAKYMAWLHPVDVTISKDEVKSIRPMQTTTTLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P424</accession>
    <name>A0A0B1P424_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001433">
        <property type="protein sequence ID" value="KHJ33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P424"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="246" mass="27242" checksum="0626F1AB3FEE502F" modified="2015-03-04" version="1">MEARETILNAGNGLFLSGAKLEPATNWTPVIVPTVPTTIRKEQGEIEVSKSMLTEEIERVCSIRPAHVKLYGGNKPGAPHRTWMAYFTTAPRTSFRVFDESGIARKFKKQQPLEFCKRCNGYHPTKNCSRAPSCGNCGSTNHVEERCMAATKCRNCGGPHRSDCRRCLARPTRSGAPTKEQMKTYRQAGEREYQAVLRVKTAEDLAASTQNEILDITSSEEPEAENNTNNSQAPLVESSTCGAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P449</accession>
    <name>A0A0B1P449_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cysteine synthase b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002893">
        <property type="protein sequence ID" value="KHJ31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P449"/>
    <dbReference type="STRING" id="52586.A0A0B1P449"/>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="OMA" id="FMCCDLP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="390"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="56371" checksum="A8F7510B89DB5478" modified="2015-03-04" version="1">MLTAPYLNVFSGKNALRDYYNPDLQPPLPLVEIPQKLNPFYDDGVRIYAKLMTTLPAKNVKSLPALSLLSSPEISSQTKRIVEYSSGSTIMSISMLARILHGIEDTHSYLSNKADLKKINLLRFFGLKISLFSGPSQPEPDDARGGIMRAQKLGEEDETVYNPNQYENDLNWKAHYQWTGPQILKQMPYLNIFCAGIGTSGTVTGVGLYLKKHRPEVFRVGVNNHPTEIVPGTRSVPLMEPVKFPWREAVDTIEVVGSFDSYRLSLALSREGLLVGPSSGLNLQGLLDFLKRRKEQNSLSSLAGEDGLIHAVFICCDLPYQYLEDYYEKLPSSFFPEITNKALLKVDRYHYDKTWEAKSADLLPDLYPSLKSMSSLADWYEALSDSTTISDTGYQILDLRTAKDFNIWHLPGAISKPLVSLTAETRNPFFDTETMEVIWSELMIMFSSHTAKNMAGSKKVALICYDGDTSRVATSILRARGVAAVNLMGGMNGLADQVRGLSHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P474</accession>
    <name>A0A0B1P474_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dcp1 superfamily decapping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002871">
        <property type="protein sequence ID" value="KHJ31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P474"/>
    <dbReference type="STRING" id="52586.A0A0B1P474"/>
    <dbReference type="HOGENOM" id="CLU_058649_2_0_1"/>
    <dbReference type="OMA" id="LFVCTQS"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="180" mass="20279" checksum="2D18FABD98177A41" modified="2015-03-04" version="1">MDSNLSRLHAEMNFSVLRRYVPSLRDIIAIAASASIYTLTPDNSETGAEWKRADIEGTLFVCELGYGPDQHCLVVLNRKGRDNLIIQFGEIVDVEVTNEFLILRFSSNGEARILGFFIQCSGCSREEICELIKGLWEAATKQPVSSRPININENPKIIETKTEFKPIGRKLSLSELFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4I4</accession>
    <name>A0A0B1P4I4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1807</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01001582">
        <property type="protein sequence ID" value="KHJ33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4I4"/>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="332"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="399"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="463"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="768" mass="88284" checksum="C310F6D3B4FF981C" modified="2015-03-04" version="1">MSFHSSVRKRKEYSTKLENKESNPLLSGFKKSERPDSIKKVTEKSEPEWDYRISLSIITILAFVTRFWGISHPNEVVFDEVHFGKFASYYLERTFFFDVHPPFGKLLFALMGWFVGYDGRFHFENIGDSYISNNVPYVAYRALPALLGALTVPVVFNIMWESGYTLPACILSACLILFDNAHIGQTRLILLDATLIFAMSCSLLCYVKFYKERHEPFGRKWWKWLLLTGLSLSCVISTKYVGLFAFVTIGSAVAIDLWDLLDINRSQGALSLPEFIRHFTARAIALIVVPFLFYLLWFQVHFAVLSRSGPGDEFMSPEFQATLSDNIMTANAVTIDYLDVIQIKHKETNSYLHSHPDRYPLRYDDGRISSQGQQVTGYPYSDTNNHWQILPIDNNVTLGRPVKNNDIVRLRHIATNTVLLTHDVASPYYPTNQEFTTVSIEDASNQRVNDTLFEIRIENGKQGQEFKSFSGHFKLIHFPTKVAMWTNSKPLPDWGYKQQEVNGNKNLGQSSNIWLVDAIPSIPPDSIRIIKKERQIKSLPFLQKWFELQRAMFFHNNALTSSHPYASQPFMWPFLLRGVSFWTKNDTRQQIYFLGNPVGWWLTSSLLAVFIGIIGADQLSIRRGVDSLDTRSRMRLYSSTGFFFLAWAMHYLPFYLMGRQLFLHHYLPAHLASTLVTGAILEFIFCVRLTDGDFLEDDKKGTLTKNKPARLKIPNQDLSSSWIALVVILTIVIGGWYYFLPLTYGFPGLSPSQVQARKWLSYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4W3</accession>
    <name>A0A0B1P4W3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002138">
        <property type="protein sequence ID" value="KHJ32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4W3"/>
    <dbReference type="STRING" id="52586.A0A0B1P4W3"/>
    <dbReference type="HOGENOM" id="CLU_036204_1_0_1"/>
    <dbReference type="OMA" id="SWINESK"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="294" mass="33567" checksum="556E20D84ACBE3F6" modified="2015-03-04" version="1">MDSSAEEDDTRRRDEIDELFNYDAGVNDPFSDNYQPAPLPERREKTVQTSIHPSNDLGIDDEITLTRKRRVPRVKLDENLLISPAGIPKLQSKAKSLKFKGKGYEFSDISNLLHMYQLWLDDLFPKARFLDALAQVEKLGHKKQIQTMRLSWINESKTDYLSTNNGSRDKNPASHHEISETTITRPFEDDLSINQKNIDNIAQDDLYEATPHPVSSRDTNSLSPSKSSTLNPTLLLEENEDQVPEDELDILMAEGEELPKSAQADIQMASSTSRDQNICFDDDEEAMHEMDLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P533</accession>
    <name>A0A0B1P533_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0936</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002377">
        <property type="protein sequence ID" value="KHJ32056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P533"/>
    <dbReference type="STRING" id="52586.A0A0B1P533"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="OMA" id="ITAKKYV"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000082">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="35770" checksum="C257030C43D0E895" modified="2015-03-04" version="1">MDLVNHLEGRLLFAVPKKGRLLQATLDLLNGADIQFRREHRLDIALCKNLPIALVFLPASDIPTFVGEGRVSLGITGRDTVAEYMSSVERKNRKRTELGKLRVDSEALDIKCGCREIMDLNFGMCKLQVQVPENGAYKKPMDLIGKNIGTSFVNLAKDYFSSLEKTAMKLTNGEAAKATLKTNVIELSGSVEAACALGVADGIVDLVESGETMKAAGLKAIDTVVNSTAILIQNFHSSDKEMIDLIVSRLRGIVAAQKYVLCQYNVARSNLEAAIKITPGKRAATITALEDEGWVAVSAMVEKNSIASSMDKLSLIGAEDILVIKITNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5B5</accession>
    <name>A0A0B1P5B5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002315">
        <property type="protein sequence ID" value="KHJ32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5B5"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="42579" checksum="B6D4275DCD6C6D8C" modified="2015-03-04" version="1">MVTVHAKRFKSLKLLRRNGANNLPQFPQYPVPNTPSLSTPSSQPLDIQVPNKSLAGRQILKPSAPSKRPIPEKIPQNSRENTGVENAFLPKELAEIIAARQRRERAWHVRVMICTTVLNNIDSTLANLTEDIEKEEAKAIIAYLRLAISNFAAADSSPYLPRVPTHTRPSKDNGNGKGKEIDKNLTKKIAVATPRLILNQVPDRELNINAELPRIPKLSDNSWATVARKGQKKSQIDISTSARVAPANKTAIRPTNIDKTTSPTKAISDKRHFLRLPQEHKWRKLSPAGIREVIVKKLLISPSLMRKIKPVHSGFALSPSSSEAQEQILKAENGLFLSGTKLEPATNWVSILVLTVPAFIHTEQGKVEVNKAMLSDDIERICSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5H1</accession>
    <name>A0A0B1P5H1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Putative endoplasmic oxidoreductin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g0414</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001970">
        <property type="protein sequence ID" value="KHJ32585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5H1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5H1"/>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080494" evidence="19">
        <location>
            <begin position="23"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="407"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ32585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="67732" checksum="C564141B4F6ED134" modified="2015-03-04" version="1">MMRSILHVFFSIFISLAGVSHCVDQRIALDTQPQPRFCTDSPNSIISDACTSYSALDELNTELRDILVDITRNTDFFSYYRLILFGKDCPFWNDDNGVCGNIACAVNTLDNEEQIPPIWRAKELGKLEGPMAIHPSKQIQKKRNLQRPLDGRLGDNVRESCVIEDDERNYCISEEENTGLREDYVSLVDNPERFTGYAGEGTKQIWDAIYRENCFSGTPLSFLETLNPQQRVAANELGRVFRDQGQQKNQKQNLFQISHSVGFEDGCLEKRVFYRIISGMHSSISAHICYEYLNQTTGEWSPNLQCYKDRLHGYTDRIGNLYFNFAILLQATRNLGPYLKEYTFCSHDTSQNLITNDKVQSLINTISSAPKFFDQSLMFVNGEGPSLKEDFRKRFRNVSSIMDCVGCDKCRLWGKLQIAGYGTALKVLFESENNSKDVPKLKRTEIVALFNTLARVSSSIDTVKYFSSIINDENQQKIKETPQISSDRAGKSQFMKEQFMKGNEFDENDLDEFRRTQYSLDSSLSANLSSELLIFWKVTKYVIRSWLQFPSKLWQILKFEIPRAWNGYIGLPVKPRKWIFKRPDIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L9</accession>
    <name>A0A0B1P5L9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="JNVN01002446">
        <property type="protein sequence ID" value="KHJ31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L9"/>
    <dbReference type="HOGENOM" id="CLU_014602_3_1_1"/>
    <dbReference type="OMA" id="SECTACF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="424" mass="46768" checksum="38BCEFED634964A9" modified="2015-03-04" version="1">MRKILNNIKSKQEAGFNVSATDFWGRALSFQLIDAPDGGPAYTFSSIALQDDFKDGSIPLPMLVATRSLSKKAQNSVISNVFEMNPFELGTWDTNIAGFAPMEYIGSNFSGGTVPFNDPCVKGFDQVGFLIGATSTIFEVAISRFAKSKRFSLIRNKLQNLKNGKNNVAHFQPNPFFGFNPDVNPTVKSKDLSLVDGGLDKQNLPLLPLLQQSRKVDVIFAVDSSANLQNFPNGTALVATYERALKGKFNSKFSFPSIPDQNTFVNLGLNKRPTFFGCDASNITGDAPLIVYIPNSKYSAASNTSTFKRKYSESLRNQIIQNGYEFSTQANGTVDPQWPVCIGCAALSRSMTRTRTPIPTACQNCFSSYCWDGTLNQSYVEIPVPVKKSRKSFFGRFSSLGSFLRNKLTPGPKILPRHMHLKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5U5</accession>
    <name>A0A0B1P5U5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002383">
        <property type="protein sequence ID" value="KHJ32049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5U5"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="711"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="858" mass="95705" checksum="9AD66612444AA9F7" modified="2015-03-04" version="1">MSSRSSIASHLDSAQQRNTNGARLIIAITSAEHGEAENTPTAAEHQIDEEIQKIKRYELINESLLLDWVQDAAKEHLWRKYRQKENIKFSKNASLIGLRDRLTESFEAAHGWIVVTLIGITIGVNAAFLNIITEWLSDTKLGYCENAFYLNENFCCWGADNGCNEWHRWSSFSLVNYLMYIMFATIFALISATLVKLLAPYAAGSGISEIKCIIAGFVMKGFLGFWTLIIKSVALPLAIASGLSVGKEGPSVHYAVCTGNVISRVFEKYKRNASKTREILSACAAAGVAVAFGSPIGGVLFSLEEISSYFPLKTIWRSYFCALVATAVLAAINPFRTGQLVLFQVHYDRSWHFFEIVFYIIIGVFGGIYGAFVIKWNLRVQAFRKKYLTNYAILEATLLATGTAIICYPNMFLRIDMTQSMEILFLECEGAEDYNGLCDKDNRLKLVFSLILATVIRTFLVIISYGCKVPAGIFVPSMAVGASFGRTVGILVQALYEAHPTSVFFSACQPDVPCITPGTYAFLGAAAALSGIMHITISVVVIMFELTGALTYILPTMIIVGVTKAVSEFFEKGGIADRMIWFSGFPFLDNKEDHVFGVSVSQVMASNIFALPSKGLSLKDIEQLLVEVQYKGFPIIEDKRTKILLGYIGRTELQYAIDRVKRERNISSAAKCYFTPLSLDTDSMVDTQVTSSTPLAVNSLESSSIDFSRYIDSTPIRVHPQLSLDTVLEIFRKIGPRVILIEYHGKLAGLVTVKDCLKYQFKAEASENQHEDRLIAETSEWLWNFINITASFFSENLSRLRHGQIRFELSSPITNRTNHRMVSQDSLQRQRPLTTGNSNESEALNSYNVEEIYELSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5W0</accession>
    <name>A0A0B1P5W0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001064">
        <property type="protein sequence ID" value="KHJ34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5W0"/>
    <dbReference type="HOGENOM" id="CLU_494486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="64019" checksum="93ACA5092ACA0A4B" modified="2015-03-04" version="1">MARINDQEASYDTPAAKKNRNHRPSFIDQLDSVPETELITKKDVLQLATHCCNVYDYWMNHQEEFSRDHDTRTKRRQTLLSLSNAARGDHEPIAKNIDDVDVVDLREYTDWFMNHNTDINLRFDSANTLNEAVNQQPETWFLFLRYMTHSLHYADLHIEAQNTEIDNLRTTNEDLCSSNSPATITILKKKKYRDTIIRLREEVEALSKERDNLKLSLERLNIQGDYDSDDEFLNQDTQKLTHTAVSKSAALIGSSCNGVGNSKPPDRMEVFDGQNRDKYDEWVDKFLGQIKTHENWFSNEDRKLTYLMRHLTSAPYNLLKPKYDERARAKPLHGRTLSGALTELDRAFRAYDMRRDAKTKLETLRMGNNESFGDFFAKFQIQINKLDYHDEDKIDELKARLNGRFASKIISGRKDTYEELVNQCYTLDSELKMYEAKKTTSSSSGSRYPGNLLIPKPQVDHATVELGKSFKPLFQMTLKELKDYRNSLPRSNIIKQRLIDEKRCHRCMQKGHTGSDQECQFNRLPPTENFKSQQMALLNQLSISEKGKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Z3</accession>
    <name>A0A0B1P5Z3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002175">
        <property type="protein sequence ID" value="KHJ32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Z3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Z3"/>
    <dbReference type="HOGENOM" id="CLU_015384_0_0_1"/>
    <dbReference type="OMA" id="NDALNTW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67956" checksum="67E4C3C14174DCEF" modified="2015-03-04" version="1">MKPSIGENTSTSLASPIGSIARQQSRHASPSNEGIRPRYKRLESFNSEIFRKNSTSTAEGSRTVSPAASVKHGHNEEVIQPLRTGLNQYDEASNKSFIPVRMKKSLWDGSWSSFGLNSLQEIAFSMIADTYDSKSSRVPTYKKEDWFGKGKGRRLTEWGPEGELSQQNHTNIGAGIVGTREDKVKEIKKTRILEGQDDDNNITDETGNYKRRTSFVETGLGGKEEDDFSLVYVHYVQPHDTIQGVVLRFRSRMDVFKKANRLWAGDSIQLRDKVFLPVDACEIKGRPCQPPTINSSVELKSPTSGLNKDESNFHSNDNRADQNSIENFRGNGCLHDKESSPVHVQWVLLEFSPIPVEVVRIPRKALNYFPSRRRSLTSLSTASTPRISSDIQSLCRSSFESQKNSSTQKISYMGQQSSQVNTLSSLSRQPFLSERRESSIETPERRGWLQGPGGVGTMGKNVRKPGPAKDALNSWTSKQFPRIAIDSLPSTSAVSTESANLSLDSEVIGPIITDGISNHSLSMNSNSSLVFPNVNLNGVESWVRKMATKIQVPRNLREDAIEMLDGIASDDGRIFESSAGKSSATTSRVGINEDGFETSIRGRGKNRKGEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P620</accession>
    <name>A0A0B1P620_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001269">
        <property type="protein sequence ID" value="KHJ33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P620"/>
    <dbReference type="STRING" id="52586.A0A0B1P620"/>
    <dbReference type="HOGENOM" id="CLU_002197_0_0_1"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="913" mass="101289" checksum="E6739EEA573399F0" modified="2015-03-04" version="1">MANKKARQLISYVLPLSNSSGGHRLGVNGLAVDSERSILYSGGRDGLICAWNLNLDLLNTEKHDDSAKSTDISLPSTEFRNQVEAHTHWVNDIILAFNNTVLVSASSDLTIKAWRPLSDTKELPQTIGQHSDYAKCLAAPGPQSNWVASGGLDRKICIWDLNGSGKKLEIETKDEERVEKGSIYALAANQDIIASGGPDSIVRLWDPRSGSRVTKFVGHTDNIRDILINGSGDTIMTASSDQTIKVWNVTACRCMYTLTMHNESVWSLHSDDSELKTVYSSDRSGLVLKTEFRGLIGEIDDGITLAIAQENDGVNKVIACEDYIWTATSSSCINRWANVDTASIKSLGTPGMESINPNSEFFKPEMSDLSRLGTPNTSGFLITPPDDNGISIDLSWGGARKGSVTLGTSQVLIVPVHALPQETIKGHHGLVKHKLLNDRRRVLSLDTSGEVLLWDLLNCVPIKSFGKRNLDDIGLEVNTLEAVAPWCSIDTRTGRLAVILEENNCFDAEVYADELELEEPAEFREDQRINLGKWILRYILSNLLEEIIHKDELFRRALIDNKAENSSRSSLVIKPCSPINDNCDSSNGIVALSPVSPNHLPRLPEDSTAVDSKTSPTNHNFGDSYSPTSVESLKTLSTLGEILSQEKHTSVSNEAEKETPKETNSFFGKKFRKGMSFGSRKIRSFSNSEKNAIVDEKVIDGSEMCDNEDMEQKIEDNFGGVIQRIRMEYKKKILENPKGYLESRITPCQQNETPLLKPPPLTTIIIQEETSGGCVDLYRGTVASVGKDMQMIEKRAPLWLGELLLKNKIPNKDPIKVSFVLQPWKNLLPSIAGPDGNIRLNANRMLRVKKILAYIAERIESIPEIPNASSMKPEEYLDLYCYDQKLPISMTLATLRTYIWKGGADVMLYYKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6B4</accession>
    <name>A0A0B1P6B4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002042">
        <property type="protein sequence ID" value="KHJ32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6B4"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="15972" checksum="C095CBB26666FD18" modified="2015-03-04" version="1">MIDEEIDRLIAIGLESSCWATKDSTMSLKNSTPSIHGVEKPKSTDRVDLLPPSSTSTVQVQQNMSPTNEEPTVVDLSISQASSTTSPSSTSHDTPMLIEKIRELPCPPELRVVVEAEIRRAAQTAANIELCTVAVNYVKAALAPLAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Q7</accession>
    <name>A0A0B1P6Q7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001135">
        <property type="protein sequence ID" value="KHJ33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Q7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Q7"/>
    <dbReference type="HOGENOM" id="CLU_318899_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="103527" checksum="AB64AC9AEAD599F2" modified="2015-03-04" version="1">MIEREKHINTIIENLILSQKPITDSIKQNTGNSTIVKIPDKHKNKNNTETSKILDSSNRASEIEVLEESKMAGLEKRSGDFAGAEMPSLSVLPIINVTPFSGKDQDAGRWIAVLESKFIQAGFNSLEDVPGWMWVKAVWMNATTDAALWMDSTPHIRKITDKVKTRRPIEISGLERDLFTDEFTRRFELVVAPENEPQQQKMVNELRQEKDESLRDYFSRAQGILRVIGADDSSEYRGVASSANKFVIEMMVDRFVLGIYDEELNARSVDRGAASSGSLHQAFQVIQGCQTTMADQARQNEMWQQMYKAKAFDFIQENPSEVNAVVNDFAQFNVDSVRRGNFRRPFVGTGVSSALPGRILPTETYSTQETRQQLILPALPPPQSLIDDQQYKNNSGYQGPPQRESWRHRKILRSKSQENMARATASQVISGHVQSSWPIHGTETPYQVSESNEIPVNFDRAQMIERSRSPPTKTQPVYTGKTVKFEEFLSQADASDQSEPNSRVSSSGNAVDCFTAEYFLDEPITCDQSKKVETTISKLKIDEPIASEVLLTAHVNELLARKRQRVEELLNDEDVEPRQRHGSFRSSTENNERNPEMKKRREKGKRIIRGRKEQGDVNYKNILERAEFKTNVLEFAQASTSAQNQFKKLLTGENSRRKKRNPEVFQAAIKGREDKEVRFESQHIKDTFQSIQPHQYKSFQLKTGFTHADQGADVCLISASLAKALAVVHKILPVPMRFGTADGGTTVAKHFTSIQIGVAEIWRKVDVLILPQVKNDPHSLLLGLPWLYQVNARIDIPTFSLRIGDRKVDGRRVEILTTRFKLGKHQNIRLAIEDGNVAKLIQTEMESKNKESILDPFEDSSNSETSVTESDESESEYSSEEEERILEEAKIRYRNSGKDIVTDVTKKRQNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6R3</accession>
    <name>A0A0B1P6R3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g0194</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002169">
        <property type="protein sequence ID" value="KHJ32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6R3"/>
    <dbReference type="HOGENOM" id="CLU_005034_0_1_1"/>
    <dbReference type="OMA" id="SWAEVYH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061921" description="ER membrane protein complex subunit 1" evidence="13">
        <location>
            <begin position="21"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="15">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="14">
        <location>
            <begin position="740"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="973" mass="108445" checksum="8DAA6B17274991C6" modified="2015-03-04" version="1">MSLLYISLILILHIIPRIGAILADDAYLVDYHYELLGLPLQETTFFFRPRKDDKATLLYTLSDLNVIGAINPGTGKLVWRQIIDNQDEKGFIRSVDEEDAIITGVGGRVDCWNAMNGIMKWNVEFPGVIRDLQVIKTITNEKTIQKILVLLEEEEKTVLKLLQCDSGDLIWDLRENNSDIPFRINGNSNDIFLVSLLGAKNNFNIRVTTIDLENGKKRNEFMITSKAEISSSDDVFVNTVNSAIPMLAWIDKATKNIIVNILTRAGPVSNKLPIEQTDSINKKVIIHAPNIFESQPHFLVYLESEKSNKAEVYHVDTNSGIAKKAYELPRLKGKSVISIICEDSSIFFIRTTQDEITILSSTSDKQLGKWPVKIGSRGDFIHATTEIVRRSENSYAVRSAVLTEIGAFTMIRNGIEAWVRYEGLSGAVAAEWAEIPGKGNLVATLHAEAHSSVIHAYSHRVKRHFHDLRFLPQYLQDIPKRILGSILSTELATKSEGLIRDKFGFNKIVLLATLRGNIYALESNKKGSIVWSLKAFERSISYKWNVKGMWADSAKGTLYVYGAYGEFLVLDYTTGKIIEKFEPEKPLSVSSTALVENERGRWLLPIGPNGIPDAVPLNQAPSGLLVTRGKDGVVQGVVFVIKNNQTLPCVTWEFQPGFEKKIINVVSRPSHDPVASIGRVLGDRNVLYKYLNPNIILVTAVSDQASTASFYLLDSVSGQILYSTTHYAVDTKQPITSTLTENWFAYSLWSDVNPDSSRPNSSKGYQIVVSELFESKFPNDRGPLGPAEKFSSLEPSDEPNSQPVLPYVISQSFIIPEPINHMKVTQTRQGITSRQLVCTLYRSNAIIGIPYVQLDPRRPVGRPTTSLEAEEGLFQYQPLIDFHPSMIITHEREVAGVKGIITSPTLLESTSLVFAYGIDIFGTRVTPSLPFDILGNSFNKMSLVATILALAIGVLILAPIAKRKQINKIWMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T1</accession>
    <name>A0A0B1P6T1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000895">
        <property type="protein sequence ID" value="KHJ34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T1"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27799" checksum="CD16515B0D33CBDE" modified="2015-03-04" version="1">MNGSPEGKEGLCESSWLSQTCRAYWAFTPAPREGEGESEDFDFTGRMLQRKNDNSYRGLKFVQLDKTSLELFIVTHSSFANNTDHSYQIDFVIVLADCNKRANILHWSSIKCRRVKRSVLAAELYGVVYGFDVGSVIKASLKKMLEQHIPLTLCTDSKPLFEFLVKLGSTQEKRLMVDLMSLRQSYERRELTHIRWIRGDSNPADAMTKSKCSNALKRMIDKNNITVDSYEWVERNLDNSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P754</accession>
    <name>A0A0B1P754_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001062">
        <property type="protein sequence ID" value="KHJ34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P754"/>
    <dbReference type="HOGENOM" id="CLU_645901_0_0_1"/>
    <dbReference type="OrthoDB" id="3437384at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="48778" checksum="EB824CB81464CF55" modified="2015-03-04" version="1">MTTKPRATQSPKYRAQFDSKIDNKLPYKNNSGLRSREIESTFDRMVNEDEKKISYSFNGPKPKVTAGSVPFDRLNSSKEAESPWHHALGNRAGKDSTGLTEEKMNEENFIKRQKLVQGAPLKSAISVFSDLRLKSQKEVIQERHTAAAEQYRQKISERKAKMEEEMNSWQAELEATESKAKSKSQKLLKQMKVDNRFPTSWSRYSSHDRTERLMRSLSIEQIKVRDFANLGYKDNEIIWCLAHNADGHKTELDETSQKNKFKQRVENSAVVFLYKIKVFDVQKQAARARGRRGSLSVAGEMEYPELELLPISLMTDIEIANEVQEDERKRLEKELEKIKEIMVEKVKKEREIEEKTLESEGHISRHNSFSEGLLYPDVVDVMADVIVDNVVAVEPITTMPIIHSIPNGSDVLNGEITPNLFSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P790</accession>
    <name>A0A0B1P790_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001039">
        <property type="protein sequence ID" value="KHJ34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P790"/>
    <dbReference type="HOGENOM" id="CLU_047423_0_0_1"/>
    <dbReference type="OMA" id="QDWRVYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54586" checksum="51FAA861758E9E4D" modified="2015-03-04" version="1">MEPQLSIVCLNNGKIPAPDQCEPSKNLDDISPMSNNGRKSSYTLTTPYTNEKNLDQVSASTVTSPVEQSVYFPFEKIPYIESAEKQWVEEPPPPVIIQPAPPDSENVNSIIEKKSVLVRKPFWERHLYLILGIIALFAIFFSIIGVLISRLRPHKENIIDITQNFTRNSVACTGLTLNDSKTWNMQVFSQNSSGNIVLQVSLDGEKFEPATNISLDILPRKKSPISATAAQDNLTGSVMLNLFYVSGNNNITMSTIICANGSAKCDSIDNQLIPTEIPVSRDTGLAAVNVNNTQDWRVFYYDQFGFISQLQGNTSGFNLGTRIGGEGLNGSDITAVNVNSTNNNIHVFYTDMLTQALFTLQFQSNWSTPRPVSNTRVNNWNPHSGLGSAYRPSLDQLHVYYTGLDKGVYEFVLNGTSGSDGWAGSNSSFYPQPDGSRPWAEADYEGADISAIGWKDQVRFFQPARGRMVMGELNNKTWGEIFVDMITSGSKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7V3</accession>
    <name>A0A0B1P7V3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative duf895 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000956">
        <property type="protein sequence ID" value="KHJ34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7V3"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OMA" id="YTYQAND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="488" mass="53592" checksum="5E8C55C67C3452C0" modified="2015-03-04" version="1">MLSNTTDSSVERPVKESLKTLAENPIDTSLQLTRFRIPRHRTAMSQVVLVGLFAFCTVGMSNALGGAGGGGLLNTTQSTNANVAVYTTFSALAFIGGTIYNRIGIKLCLAFGGIGYACLASAYLTTSHIGDRAMPWIVTAGCIEGLSAAMLWTAVGAVTTCYPTEQTKGKAFAIFWTIFEMGGVLGSIIPICMDWDSTSANLEDGSYIAFIVIMLCGCFIPLLLIPSDQVIRIDGSSVVIPKMPTWKSEITGMCRLLLQNSWVLTLFPYFAASNWFYTYQANDFNVPNFTLRTRYVNGLWSNFFCMVGVWTMGTFLDFPFNIKLSRPTRARVGIIAVFITSIIVWSGGWHLAKNSKRGESPIPLIDITETRRYIPFGAIYIAYGFYDGCVQSYANWIIGSLSNNSAVLSHYAGWYRSIQSAAAAVVWRLDGMDVSYRNIFISTWCIMIGSVITSFYVAFNKVLEQSEDEASSTLTPPAKPDETMSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X9</accession>
    <name>A0A0B1P7X9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7X9"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OMA" id="LGHKDFH"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="462" mass="52348" checksum="20B4764178721234" modified="2015-03-04" version="1">MRSKYALGNLSKKALKLSKREKVQSIIKSYLSTKTNLRRKTSSFCFSSPVVEKEPPQTSVQIGEDSVISQSSRKLQSERIHIIGMGPTGQYLAHNISQLDHAPPITLLMHRPFMVQDWYNEGAAIQILRNNKISTQTGFDIEPSVSFNRPSPFKRYHKNGCVGDVELAKEPSDNVIDSLIVATACSVTIPALEPIQHRIKPTTTVCIIEKGMGIVYKLNKLFFTDVKMRPTYILGNLNHQLEPTENLFTHIERGPAELFCSKLPRHYVSVLDSGTVVERTDFSWPPEAKHLIGTLSRVPELNTETLGHKDFHMKQLYNLAICTVIESLAVTFDCANGQLLYNYGVSNLMRLILEEIYLIVSSLPELRNIKGVDAVFSPESLEKTIIGHLHRSAVTVSPMLVDLRAGKRTAIDFYTGYFVERANMLEIPCPINQMMYNLVRGKQTMRRRENDNHIPFTKYVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A1</accession>
    <name>A0A0B1P8A1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8A1"/>
    <dbReference type="HOGENOM" id="CLU_117291_2_2_1"/>
    <dbReference type="OMA" id="MKDHFRS"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="117" mass="13483" checksum="6C6AD178D2F6B5F9" modified="2015-03-04" version="1">MAIKQKSTMTKTRRRLRDLDQISEDIHSPKHLEQYKNSKPAEDLPGAGLHYCIECAKWFESDNSLISHRKGSSHKRRLKALKETPYTQMEAEEAIGLRTDNGLRQSVQKSMEIDVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D5</accession>
    <name>A0A0B1P8D5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D5"/>
    <dbReference type="HOGENOM" id="CLU_148782_1_1_1"/>
    <dbReference type="OMA" id="WEWHPSR"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="91" mass="10403" checksum="5CE762A36463BFCA" modified="2015-03-04" version="1">MGGGGKIPYPKHVWSPAGGWYSQPKNWKSNTAVMGLFIFGVTALAFRLSAEREVRTRFPEEGRFFPSRYWSKQIIEHEREVKARKAAENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N6</accession>
    <name>A0A0B1P8N6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative dna cross-link repair protein pso2 snm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000546">
        <property type="protein sequence ID" value="KHJ35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N6"/>
    <dbReference type="HOGENOM" id="CLU_005260_4_0_1"/>
    <dbReference type="OMA" id="AQIHMQM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="753"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="917" mass="103461" checksum="F5A7D93595EA0C29" modified="2015-03-04" version="1">MFRNPRENLHLSTENLLKPSVGRPPTPTESSQTANKYSPRTKNTLNSRRNMKTLSSAKKLEQSRKKLSVKITGKSNATILDFFKKVDAPVKEDSIFLEGGTPFGHRFPSPILQDLEIDAEENYDQTRFNEISGSVKRQRISEDDRLKHETILPDSEILNSCNGLSNENSLILVKTKANLRKDGPFFEDSDTDDEDQKPNSNSLPSLSIETAASRNKDLDNHTQISTKQDSESASGFRSKDNGSEDSFSNKYSVSTQENVQRIGQKFDVSNVKSESSQILGEQIKTQINELSRSSGEWEFFEDDEIMTDGFNAGEEFVGRRWIEEQCKFENEDETFKANEIYIKEPRNLQASPTTTICPVCNAELRDISETLFSKHVNECLDFSLTPKLVSNQSELAEIKTKKSESKSKFASKAAIPRPGQESPFEIEIIKSKTSSAFSKLMSGKVEEMAWANAAASDYSSKGKPAYQRTCPFYKIIPGFSICVDAFRYGAVKGCNAYFLSHFHSDHYIGLSSSWCHGPIYCSKVTANLVKQQLRVDARYVIPLEFDKKFRVPETPNVYVLMIPANHCPGSSLFLYEKVAEAGSSTRSQRVLHCGDFRACPAHISHPQLMPDVLDSVTNKYKHQIIDICYLDTTYLDPRYAFPPQEQVIQACADMCLSLKNEYVEEDSTLEVIRREHISSSISKFLEPAVRKASGESLMISHQNSRNRGRLLIVCGTYSIGKERICLGIARALNCKIFAPTRKMRICAALEDEELMSRMTNDPREAQIHLQMLMEIRAETLKEYLNSYKPYFSRVVGFRPSGWTYRPPKSRGTQTATIPQILNSPSWRSSFSLSDLVPQRGSTNEASCFGVPYSEHSSFRELTMFICALRIEKVIPTVNVGSAAGRTKMKGWIERWLAERRKNGPITIGNGQGEVNWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8P5</accession>
    <name>A0A0B1P8P5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001656">
        <property type="protein sequence ID" value="KHJ33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8P5"/>
    <dbReference type="HOGENOM" id="CLU_2401313_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="93" mass="10184" checksum="2F9CCAAF18124BBD" modified="2015-03-04" version="1">MTSGVMKVQLPQTKLTGNATAQGLKSGSHASIKLSPKMEKGNIEDSFRNFKLDELSEDPITSDMNLSMTNQSLQYQILNGCQGVPECMLNSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P926</accession>
    <name>A0A0B1P926_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stag domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P926"/>
    <dbReference type="STRING" id="52586.A0A0B1P926"/>
    <dbReference type="HOGENOM" id="CLU_003254_0_0_1"/>
    <dbReference type="OMA" id="FVANVQD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="341"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1180" mass="134431" checksum="A76C4324679D0403" modified="2015-03-04" version="1">MGDLQIETTKSPTTGAQRRRSGRTIKPPQKFAPVVTPSRVTPKRKRRADVESDSSDLDDDDNSDTLKNNTHSKPSKSQRKPQSTKKPATKKLKSNGRFNLAENNVVKLPSRLKKNVNRRAVVEDNDAKGLHAELFSGGERTEDVAAQWLQKYREDNRQALADLVNLVLRSSGCNIEVTLDDIDDVDNVDGRLADVQNEFQMQNISEYPLISRAKSIQSFRSKLTGFFDKLIEVLHESEALYEETVLLENIHQWIAALSSSSTRPFRHTATLIALTMTSARCRIAHAEIEKGARVQRQLESEAKSKKPNKARLADFQRRVDKNNEKKAIIEGQIQDNFETVYLHRYRDIDPKIRLECTEALGTWIVTLDSYFFDGQYLRYLGWMLYDIHGPIRQAIVIQLQKIMKTLNHGGIRHFIDRFRSRLIEMATRDSEPAVRSYTVELLTLIRDAGMLEPDDIDDIGRLILDAEPRVRKTVVNFFISNVNDLFETRLQEIYGDEAQERIKNMSDEDIIDSPRVSWIKFKCLAEILVEYDGRDQEDVLNRINIPRFLKVNISESRFTLVAQALYEKMPELKEWVSLAGYLLYDHTTNTKASESEMEHLFSEAVKPIEREEVVLLEILTSAVKVSLQHLEEPTKSEKKKLSRTDIMEAKEMSTRHLADIIIRLLNRYGADPQPVTIVLRLAQALDFKFFHDEIQQNSSNCSKLLDQICTQFKSHADTDVLTEASLTLLHARGFEELEEITNNKIQLLWEESISMLQKINQVGEISIRGGSFSRKDLTEISHILARIEQLSSISNPVEFMEINSRMGEPCLITLIFDLIARGELIEGHDVAFDSIEDSIVQSAMRSGLFYFMWKTLKLSNAQEGQGLSETDVDQLKERQEIFITNVIASFSSRADLDEVRLLGAGIFIDLHITFVSTLRTTPITDIKSNKTILNSDIGHSQEEISSLVKSISTDVQQELTSIFCDLERQFAKKAKKKLNPPGDDEAPEDLDSESEDEDIDGNISEQQYSEILSAEKQLCQFTGKLCLAILAQVIDSSGPNSGKLRSRLLRNRQLLGPNFKEIVACLDEPRAQKTKKTSKNKAPLLEAADKRKKSSFKSTEFVGINEDNDKNNMNEPHDDLEPDIVDPFIEEDEEESQDLDHDQVEIEEVEENENENEENEGKKSEKSSDKVEDDDTIMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P971</accession>
    <name>A0A0B1P971_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amid-like mitochondrial oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001566">
        <property type="protein sequence ID" value="KHJ33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P971"/>
    <dbReference type="STRING" id="52586.A0A0B1P971"/>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="OMA" id="MAVTHQL"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="40678" checksum="84F63130ED90B308" modified="2015-03-04" version="1">MAKTILILGASYVGIGVTHGILKHALKNNQLDYNVVLVSSTTHHYWNMASVRAIVPGQFSDEKLFASIPEGLQKYGDIVEFVLGLATQLDTSTKTVTIKTDKGERQQQYDILIIATGSRAKGKEISPWYTSPSGYEATKEILHDFQDKVRNSKTIAIGGGGPTGVETAGELGYEYGLQKEISLITAGSKLLTSGTSGMASAADHELKKLHVNIIYGTKVTDVKPTSNGQTELLLSDGTTKTVDLYLPTLGSMPNTDFVPEAYLNESKYLMVDNFFRVKNASDIWAAGDVTDLEPPQYVYAEKQISALIHNLTMFINGKDPVAYKPGPLIMGVTLGRCKATGRLGPFPLPGIAIWFAKGRTLGTQDLQPLVSGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A4</accession>
    <name>A0A0B1P9A4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative autophagy protein apg6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001137">
        <property type="protein sequence ID" value="KHJ33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A4"/>
    <dbReference type="HOGENOM" id="CLU_024219_3_1_1"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="162"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="293"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="57238" checksum="8791877676C451CF" modified="2015-03-04" version="1">MQCQKCRSPLRFDSSLENLSPAAFDILVGASDNSQIKHIPPSRVPYPQDRKQFYEKAVKNASLLNTKRSLNTLQRIHNSEKSSNGKSGFASPAMSFVMLSESQIASSSATKSTEEAKQTFLRTNNADKNEALNGDGKTISQEVDRISRLFEILTARSDIDFPVCVECTDFLVKELQKRHEAATKERDAYIGFLKQLKADIPTNDEIRESREALSKAQKDEERAIAELKELEREKTEVEEDILKLEIKARALDIEEEKFWRERNDFSMKLTEFQNIRDSINLQYDHDSQVLDKLQRTNLYNDVFCISHDGNFGTINGLRLGRLSSIPVDWPEINAAWGHAVLLLQTVADRLGFKFKGYQLKPMGSTSRIVSLESTLPLNSRGSVQRKISTRQQQKTVHELFSSGDMPLGLTFMHRHFDNAMVAFLDCLRQLGAHVEEETAKDPNTRTPLALPYKIEGDKIGDVSIKLGIAQDDAWSRACKFTLTCCKFLLAHVSNINTTSRNRRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B4</accession>
    <name>A0A0B1P9B4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001135">
        <property type="protein sequence ID" value="KHJ33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9B4"/>
    <dbReference type="HOGENOM" id="CLU_124032_0_0_1"/>
    <dbReference type="OMA" id="QGESMFS"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="145" mass="16724" checksum="36CB9594838FDA5E" modified="2015-03-04" version="1">MDQKQIKRAKTTARHRKRKPRTQVSSESSDNDSEPIKNSQGEERKKNKENMRSDFEPLNLCVNNEEKTSQLMTDNEISAAFDEFYLKKVTNEFSDDLDQLRNANDFSEDSVAILISALQQGTSLFSMEEKRRIISADEEVKGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I6</accession>
    <name>A0A0B1P9I6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative anthranilate synthase component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000627">
        <property type="protein sequence ID" value="KHJ34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9I6"/>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_1"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005950">
        <property type="term" value="C:anthranilate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="272"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="563" mass="62907" checksum="4A3239E55890B9D9" modified="2015-03-04" version="1">MRKLRNGMTINTFRRSLLGHNCFKKFSEFVRITGCFSDQISDLSFAGIHKPSLDCVERIVRHSLQRKNAANLVPIFREFSSAHLNYSDAYLKLTNSLESDFSFLLESAVNEEKGRYVFMGTSPHKILKTGEGHGESVDPLPGLENVLTEKRVAQVPGLVLPPLTGGAIGYIGYDCVKYFEPRTSRPLIDVLKVPESLFMFFDTVVAFDRLTDLVKVITYLTVPSDLSELPIAYDTARKNIDKVYDILLSPDKVIPKQDTIRKSGDFKSNIGQKGYEKYVTTLKNHIIDGNIIQAVPSQRIAYPTSLHPFNIYQALRAVNPSPYLFYIDCHEFQIVGASPELLVRKEAGRILTHPIAGTVKRSNDEIEDKLLGEQLQQSEKDVAEHVMLVDLARNDINRVCNPLSTRVDRLMTVEKFSHVQHLVSQVSGTLRKGKTRFDAFRSIFPAGTVSGAPKVKAMELIAELEGEKRGIYAGAVGYFGYNTVDAYGNENEGEMDTCIALRTMIVKDGFVYLQAGGGIVYDSDPTEEFEETMNKARAGIAAIKRAEQQFLGQDLKQGESSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9K9</accession>
    <name>A0A0B1P9K9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytoplasmic trna 2-thiolation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000424">
        <property type="protein sequence ID" value="KHJ35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9K9"/>
    <dbReference type="HOGENOM" id="CLU_024534_3_0_1"/>
    <dbReference type="OMA" id="TDGIYGW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="325" mass="36498" checksum="90BAFF786AD59FD4" modified="2015-03-04" version="1">MERYRVRGSKSHIPKKLLFPLSYGPSSSSLLHILDGHLQGQYERMKKVAYELVVVHIDLYVTEEDREFSARKLEQFKAQYPRHRFISHGLEESLKLKEIDWNALGISRFSHIGCPNGKLQHYLASIKSPTDRADIVIILLTRLLVRIGINNSCSCILFGDSTTKLAEKTLTETAKGRGIALPWQICDEASAYGIGFNYPMRDLLKKEIVKYVSITPCLESLIIHEQVASISANPKSVTINDLMLQYFQSSEEDYPGIVANVVRTASKLSVASDNTKNCCGICGIPCCLNEYTSQYSHQPLETTKLAERPGLEPSFCHGCVKLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U3</accession>
    <name>A0A0B1P9U3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01000383">
        <property type="protein sequence ID" value="KHJ35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9U3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9U3"/>
    <dbReference type="HOGENOM" id="CLU_062463_0_0_1"/>
    <dbReference type="OMA" id="TQPNVYQ"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180007">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032215">
        <property type="term" value="P:positive regulation of telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="28748" checksum="C3E42C2F195B6CEA" modified="2015-03-04" version="1">MSQNQKPNPSNCSEEVKQNWNPDGFKLKFCTVCASNQNRSMESHLRLASANYPVISFGTGSLVRLPGPSITQPNVYQFNKTSYDSMYKELEAKDPRLYRANGLLNMLDRNRNVKWGPERWQDWQVGLPRLEHSKDQGSEGTEGGFVDVVITCEERCWDAVVDDLLSRGSPLNRPVHVINVDIKDNHESALVGGRGILDLANSLNEAAIEERALNPSGFDSGNSASRTGFDERVPEIIGDWQGRWPNLPAVWTLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA57</accession>
    <name>A0A0B1PA57_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ddenn domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001229">
        <property type="protein sequence ID" value="KHJ33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA57"/>
    <dbReference type="HOGENOM" id="CLU_001932_0_0_1"/>
    <dbReference type="OMA" id="RCEEWRK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="237"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="869"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124397" checksum="BB42DE1052E58D69" modified="2015-03-04" version="1">MEDRSAPLADYFWIAGIDSISYHDFSPNVPLSTSNPQSVSAIEEYIELDSSSIPFRQNVKVSHSRHNSSNRISKHNSFQKESEEEIDHFGSNRSSTTIKASSNVLGSKTNSYVGSNSGFGDFDFDRALLTFANERELFLDDLSFSAGAQVQKPLPMTELPPKTAERFQPREGAHIGSSPANIRRSPLKEVRGSIRRHISYREINRVKKLPTVTQRNGSVRTSRRMSDYNSVIPPPQPLNADPDMHPLKRRFEPVLLDRYPPKTATEEVERRGRFPDYVPMFAFPNDINIVSADERPRSTWHGFAMTTDEAVKLYGVTVIVWSPLNSKAAENVEQQCAEWRQSHMTTEERELAASLAERLASERAYLSRLLAQLPSIVSGSAARDALEEKISTVEEKIGLMTDLLRPVRHGAAAKIDGLTDGETGLWIPRAYGILGRDGSLVSFWKEWLRAVIVPMTDGGVLRVPASSPKIGRWQPLERYVVNLCTEALSPISSKTQVELAVRELRLFARKEAINELPGSRNTDLYALFRSLSIPNIVCLFEFVLSESRIIFLSSHTAMLHLACSAIISLIYPLKWLGIFIPVLPARLLSALEAPCPYIVGIERRYENIEMPEDDYVLVDLDENVIESPKPPVALPRQQRRKLISLIQLAAPHHNSCGVPIGPPPYAIESFPYNAFSSENPAIFTQNPPNNSFAKFVGQKSTAFGEPEIMSTRHASVFNAFLQSKNDHSRLERPSTSRSTSRSTQTSPPTSVSPISGHFPHPSTPVSRNDSGFSLTATLREKRSGHFDTNSRRSSSIGIERQPTLRRPSVPFVNRHQTTLSTSSISNDTKSIYGCASSTYAASTLAASTIMPNLLMQPVHNTDSTIWVEGHCFEHDRNDTISVCSICDEKVEGDGIYNCTKCSTRSHSRCLGTVSLVCSSAFYSDRIRAAFVRFFASIFYTYRKFLVKQSNSSKNDNGLLYKFNMESFIRSLPNDQNTYIDMLRHTQAFNEFIHDREIMPATSPSIQLFDSIILAKRSRGRTPRAILSRSKPPLFLESRSDHIWRSAAVPITTAKFPGDYHTVVSRIPAQLDNALMREPRVIQGVPRIDQCGKGKKVGRKAVPSMLGEPSKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA82</accession>
    <name>A0A0B1PA82_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001204">
        <property type="protein sequence ID" value="KHJ33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA82"/>
    <dbReference type="STRING" id="52586.A0A0B1PA82"/>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="OMA" id="HENHARF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="351"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="539" mass="61751" checksum="FBB28AB39CE9D1E6" modified="2015-03-04" version="1">MASVFPHSTSTGPAPTANEIYFSYRQAYKQQFYDGVLRPVVFPCNYLGIFTLIIYMCIPHKKSPIIYASRLPLVGLITWFELRLILETSGVGMSIGYISGLCSALTIMLSWTWLVFKRPQWDAKRVERRRVRVGKDTTKSIPTEKSSSNGSSNQEKLVHGAVQFPEKSCYKLLENGEMAYEYFWQPYPDDLKERISWVLDLILNARGPGWNWAIHNIPKLTPEVQSRLGGLAPDRKHPKISPLGQKRFVARYEHFLSQIIFSFKCFLIADVLRVIMMKDPYFKFGPTAYELPPYLKPLHPSLLQFYRLLLSACGVIAGLSMGFSNIDIFLSCILGPRVLGLRGESWYYQDVLGKFSHIFDKGLNGLWGNYWHQTFRLFFTAPTKYLIQEGYIKAGNYSTKIIGLFFAFSLSGFLHWAGSMTSFGSTSPIQEATFFIFQGIGIVFQQFLCHLLSSLILKSPRFLRQTGNLLYTLTWLYLTGWLAADDFARVGFWLAEPLPFSPMQALGFGEYDTGWNCIKYFDLSWFTGKYFWESGITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS9</accession>
    <name>A0A0B1PAS9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mlx-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAS9"/>
    <dbReference type="HOGENOM" id="CLU_126658_3_0_1"/>
    <dbReference type="OMA" id="VDYMRDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="102" mass="11593" checksum="358A3D66C3055135" modified="2015-03-04" version="1">MSKSPTGEDLNIIVPSIEEKPRLSENEKKANHIASEQKRRQAIREGFDRLTELVPGLEGQGRSESVVLKKTVDYIRAQLAERQRLVNRIEELGGQQELDINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAU2</accession>
    <name>A0A0B1PAU2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001247">
        <property type="protein sequence ID" value="KHJ33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAU2"/>
    <dbReference type="HOGENOM" id="CLU_2225151_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="106" mass="12275" checksum="17539FB003294575" modified="2015-03-04" version="1">MSDVDDLRREVRELRRRLDDAPVPVTQAEGSLPEVVILKDPPTKNPNLKPNSFPIYDGDRATYPAWRRAVLSALRIDWLIFGYTNSRVFLMIYKALDGKVLEYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY0</accession>
    <name>A0A0B1PAY0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000413">
        <property type="protein sequence ID" value="KHJ35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="133" mass="14701" checksum="686054AA2E3E94D1" modified="2015-03-04" version="1">MDGLSSKAHRAGFRLLDESGIVRPYKKQQLLEFCKRCNGHHPSRNCSRAPSYANCGSTNHSVDTCMAVTKCRNCGGPHCADSRRCLARPTRAGVPTKDQMKIYRQAGEKEHQAVQLARVAEEKAATTDKSKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY1</accession>
    <name>A0A0B1PAY1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative reticulocyte-binding protein 2 like protein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001036">
        <property type="protein sequence ID" value="KHJ34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY1"/>
    <dbReference type="HOGENOM" id="CLU_010837_0_0_1"/>
    <dbReference type="OMA" id="NNAFMKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="849" mass="97121" checksum="3D92EEB14D8312F2" modified="2015-03-04" version="1">MEQPPPPPPPPHGQYPKSSSSGLPPGNYDIFIIPPHSSGSGFLYLPSLKSNVNSFAAGFASALILVVVGSALAPFARIWWTHVNRSGGVGISILILAVAVGAWALGRIQIDRETKSRRNRNGSNGPSGANESFNNNGSYSGGQSSYSYSNSNVPPSSAGSTQGGGTSSGNNNRGPNQSQWSRSPDDADTTKENSEYADKSARDRTRENSKKREQEKKEHERTDYEKREREKKEQERRDQERREVEQERKERERKDQERRERERQRKEQERKEQERKEREKEEIKKREEARKRKEELEKRLKELREKDARERAAREKKLQDEAEREARAKIQKEQEEKEAAQKAEDALAAKKRELEKRLREEFEAKRNEERAAAVAAALAEKKKKEEEDRLRRRREYEERLKKKKAEEEAIKILEEAKRKFEEATKRLEEEELKKKREEEDKKKREEEIRKKREEEFKKRLEEMKKKREEEAKRKQEEEAKRKQEEEAKKKLTDAIQPRKSTMYAFTAGERTNPWPNGRPVSPNKESATSSAAQPTPSKVTNQPSPTIGAFKNSKTSNTPHHASKEAQRKNSVSSLNSRSSHVPTKSTTKTNLPSMSKNDIYRTKDQNKIVIKAVYSFNNAFLKTPVTQLVSGVGSVTDGLILRMTTEGLFIDDEIRNVPQREWDVKAWTMKLVELWCPSCQDSATTSASMRPSASPSDMKSKRQTMRRLWGLDKDKTASSEEIDALLFEMLSRCHNTCHVRAAAMARNMSPASSTYSVSSFGDSAYGGSVMGRQMTEKERQSLIGLHILRASIRDQEGKKYVFIVGQEESWKIVLGLQRLRKGTQARALNICGMNSNEAKNTLDYLGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT6</accession>
    <name>A0A0B1PBT6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000888">
        <property type="protein sequence ID" value="KHJ34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT6"/>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="41950" checksum="6A5557BE07E4A89A" modified="2015-03-04" version="1">MTEENKLSINESSISGSEMPGHEKSTTRRSSAELDVQAPRDNEFNSANPEILSDSELSNNDKVVDGEVIEADEDLLDEYPLDTTEIDCVHSRVSSIKSLRLERFKDVTRLCLRQNSITEIEGLSCLASTITELDLYDNLISHIRHLDDLTNLTSLDLSFNKIKHIKNISCLTSLTDLYFVQNKISHIENLSELTKLRNLELAANRIRKIEGLETLTGLEELWLGKNKITEIDGLNTLQCLKILSIQSNRITNISGLSQQKNLEELYISHNALKNLTGLESCSSLRILEISNNKVSSLQGLQHLSHLQELWASYNELDSFKEVESVLADKKELVTVYFEGNPLQLKGPTVYRNKVKLALPQILQIDASFVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBW2</accession>
    <name>A0A0B1PBW2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative lem3 cdc50 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBW2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBW2"/>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="46351" checksum="6D1C1CC7E575A44E" modified="2015-03-04" version="1">MSETLPVIVNEEQVDSRNSKLREATSKQKSRRPANTAFRQQRLKAWQPILTPKTVLPIFFAIGIVLCPIGGGLLFASAQVQEIILDYSRCFQNAPEFPAMALMPSNLVTSHFNKNSSSVHGAAPSWSRRMINYTYAPGVIVPTVQCTLNFSIPSAMEPPVLFYYKLTNFYQNHRRYAKSYHTGQLAGQAVSADAISSSDCTPLTTEIVDGREKPYYPCGLAPNSVFNDTFFSPVLLNVPGASESNETYFMEKNKGISWESDKELYGISEYAKDWSQVLVPPNWRLRYPNNYTEDNHPNLKEDEAFQVWMRLAGLPTFSKLAQRNDTHVMKTGTYSVNINHNFNVTDYGGTKSIIISTRTVMGGRNPFLGIAYVVVGGICIILGTLFTVTHLIWPRKLGDHTYLSWNNERSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC09</accession>
    <name>A0A0B1PC09_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000842">
        <property type="protein sequence ID" value="KHJ34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC09"/>
    <dbReference type="STRING" id="52586.A0A0B1PC09"/>
    <dbReference type="HOGENOM" id="CLU_007072_0_0_1"/>
    <dbReference type="OMA" id="RMQMSAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="914" mass="100418" checksum="66B57D6D35924F8D" modified="2015-03-04" version="1">MAQGKKTSDVTNGNSKYQQSNIPLQRKEISSNGNKFETTPSGNLGTFRTDVAISGGRYQCERTLQRWVSDTPDESDGSLETSLNKQSGTWDQFAENKRLFGLTTDYNENIYTTAIDRNHPQYKQRVAEADRKAKEIERSTTNNPHVAEERILNNINGLNSKMDEEDKYSKVHRQPTLPASSSNKYLPPARRAAASQTSVGSILNGPSITAQTNRTEKAAGHIETTTKNLTDGMKLKKTDNLITPVNLNDNSLLESKQGITSDSSNRKTSQIKSESKPNATATVERDVASAFKNFASQQRKNVDQIRLTRAKNDKEVKLNDLKAFANSFKLHTPVPSDLVPIIAKDPKKQKEIQAKAQRNVEEAEASKLHSQEPSKTKPSLSDAQVIRPISLTHGSNSSSSNVPNRQNNGRNINFTQQSSSRGPQQASNLQQTRSSLGNRLKGLEQTKPIQLPQNQTTTIDSRLPPTGPANKIDISISRLSGIPSLHGARLNPNSIEFRPSPYATSFNPSTVSSPQSVIVGVAPVSATRSLLRRKPLPPDERPSIAGKFDTLAFIKSLAPPSGKELAWKATGGLMPAYDTPPVWKQAVAEDKADCPIRLSYSQIFELPPYTASIFSPNQSHILPHLPPHQQQSMHLSHLAQGMVTRQSPHQLPINLYGNHQTPNPSFSGTHEDHRMLPSHSAQSFASPRLQNIPMAYPSPINQASHLTFNPQLMQLSNGPQIQVGYRSLSNAHQFISQQGHIAQMVMPNPNGSFVTPQGITPAPQMMYQGNQPPPYIPTNNSHTPLISNVNGYPSPGRASPMMANQGSQQGLQQPIYGINSGASPAPNYGNTMFSQIPPTQVPMRPFIAPNNQPHGSNHQPLHHFGPQNRRSNQNNGNLHPSKIFQPNQSQNTSVSSQIPVISQIRRIDSNDEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC66</accession>
    <name>A0A0B1PC66_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1225</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="JNVN01000241">
        <property type="protein sequence ID" value="KHJ35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC66"/>
    <dbReference type="SMR" id="A0A0B1PC66"/>
    <dbReference type="STRING" id="52586.A0A0B1PC66"/>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="51917" checksum="C3D2E76DABC64674" modified="2015-03-04" version="1">MPVAIQTVSESKELRGLNLIAAHSHIRGLGVDPDTLEPRASSQGLVGQEKARRAAAIILQMVKEGKIAGRAVLIAGPPSTGKTAIAMGMSQSLGPDVPFTALASSEIFSLEMSKTESLEQALRKSIAVRIKEESELIEGEVVEIQIDRSVTGGSKQGKLTIKTTDMESIYDMGTKMIDSMTKERVMAGDIISIEKSSGKISKLGRSFARSRDYDAMGVDTKFVQCPDGDLQKRKNVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKADIIPGVLFIDEVHMLDIECFSFINRALEDELAPIVIMASNRGHSRIRGTNYCSPHGLPVDLLDRVVIISTHAYQKEEIHEILSIRAQEEDVDLTADALVLLTKIGQEAGLRYASNLISTSQLIALNRKAKQVSIQDVNRSFQLFYDSARSAKFVTEFESRLVGNEGLANLSVSSEAPTTTQNDAMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCA6</accession>
    <name>A0A0B1PCA6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCA6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCA6"/>
    <dbReference type="HOGENOM" id="CLU_030431_3_1_1"/>
    <dbReference type="OMA" id="SWPPFTS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="56449" checksum="CEE04E240ACD384D" modified="2015-03-04" version="1">MATLQPRDPYTVDELKKLYPSNLKLQQVQVFHRHGERTPTGPRFENIGLPKFWPYCSVAQQMVSSVLENRKNEIQWSPLHWQRRIETINQDGQALAAVGPSGKNNSLCKNGELTDLGRITTYKLGERLRYLYVEQLKFLPETLEDTNIFYLRSSTYPRALESLQQVFRGMYPAKTRSSSMRPPAIYTRNDSEENLYPSSFNCKRFSQLAKAFSQRSADRWNKTTEMQYVNTLLSKYMPEDCQKIAVDSQPRLSGIYDTINATIAHGEKTRLPDEFYGTEIRRIIDKICVEEWYSGYKESLEYRTLGIGSLMGDIVDKMTNAVENVNFNGSLTANKDDSTVISKDNKNDIKFAINGCHDTTLAAILMSLDAFGNRNWPPFTSHIELELFEKSETIPAILAKTQSVEKIKKSESPEPVENSEKYQSLFDNYFVRLWYNDDVISIPGCAKPGDHLEGDKSFCTLKAFKRIVDKFVPLSRKDECLANLDTPVFLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH8</accession>
    <name>A0A0B1PCH8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000936">
        <property type="protein sequence ID" value="KHJ34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCH8"/>
    <dbReference type="HOGENOM" id="CLU_1391161_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="196" mass="21290" checksum="DB2241F832899DD6" modified="2015-03-04" version="1">MPEGKKEYGAAPFSKRALPSEPPDAGNRVLKPKTTSDRISRVIAAKTYLILATGDVFGKGVTNEKMLSEEHSSSDLNYDSNDSVESLIDQKANKPPENGPPEGDFSVLFGITQIRNDAGTSRASHISSNESQHGASSIMEAIKGLLDLNDDYLKYLEIQHPQIGADFLTLLADGASRAMSRERVYCRASKPVPTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL4</accession>
    <name>A0A0B1PCL4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000911">
        <property type="protein sequence ID" value="KHJ34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCL4"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="OMA" id="FNTHIDN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="234"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="735" mass="83770" checksum="55E00092646BDA7F" modified="2015-03-04" version="1">MDRGKIYITNVYNPPPLSHISKELGTLKYLPELLSKEGQHILAKPSKFAKPYWTNQCSEVVRETRKARRNWKTSRTVDSWIECQKASNRKKAQIKRDKTIGWRTAVSEASRDPKKIWKLAKWARKDPAEKHRLPQMPDIKDAEGLIHTEAPDKARVMAEHFFPQPVAADTTDITEATYPEELNKISKLITYMEVEETLEKLPNDKAPGPDGIPNRLLKQCRATLSKDLAELFNACINLGYHPKSFKESTTIVLRKPQKPRYDTPKSYRPIALLNTMGKLLEKLVANRISKAAEEFNLLPGEQMGARPKRSTISAVELLTELIHTIWGKDKRQVASLLSLDISGAFDNMSHERLIHNMRQKGIPKWISQFVVSFLEGRTTSVVLGTFKGDLIPTNTDIPQRSSLSPILFLFFVSTLLPMLQSRSTAAVGFVDDTNILTWSNTTEENCRKLEEQHEICERWAKTHGVKFAPEKYQLMHFTRARKKKHNLEATIKIQGQLTKPQSSLRVLGTYFDPKLNWGTHVKSMQEKSNNQIQSISRLAQSTWGATFKKSKLLYSTIVRPALTYGSSIWAKAGPAGKIPERIVKPLRSIQRKSLKIVTGAYNSTSCRVLEHECSILSIEIYLKQRRVQYAGLLDKLPVQQTIQTACKKIKPSAGGRESTHAANRSKEVLEWARICNKETSKRRQKEAGNIAAFEEWRETWTVLHKVRHSIYRNPADPKVWKAATITIDKNTGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCZ1</accession>
    <name>A0A0B1PCZ1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000481">
        <property type="protein sequence ID" value="KHJ35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCZ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCZ1"/>
    <dbReference type="HOGENOM" id="CLU_126331_1_0_1"/>
    <dbReference type="OMA" id="RGVQYWG"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="118" mass="13267" checksum="09A2F0597C183DA5" modified="2015-03-04" version="1">MLYELIAIVRVGSLDEVKDLARTAGSIILRNGGIIRSLSNWGRFSLPRKVHKNQAVHSEGQYFIMRFDSSSKTQQEVRDTLGLDPRMIRFSSVKLGDGTLAKSSRIGSQIPWLTSEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDH4</accession>
    <name>A0A0B1PDH4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2607</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000418">
        <property type="protein sequence ID" value="KHJ35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDH4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDH4"/>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="709"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="711"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="817" mass="92241" checksum="155C99661D9EA5FC" modified="2015-03-04" version="1">MRAGWFTSSSQLDEQIDKATSSSLEDIALNLEISDIIRSKTVGSKEAMRALKKRLENKNPNIQLGTLKLTDTCVKNGGSHFLTEIASPEFMDNLVSLLNAQGGTTINYDVKMKILELIQSWAIATDGHEFRYIKDTYENLLRDGFHFPPKIDVAKSMLISYAPPEWTDSDVCMRCRAAFTFTNRKHHCRNCGNVFDHQCSSKTLTLPHLGITQPVRVDDGCYFKLTNKLNKGHSFSNDRSPTSTKSQEQRVKNLMQPRSARVDDVFDEDFKKALAMSLEEVKGHSGNKSSELTDSSFGSSKPIDQSKFQPSKFSTDEEDEDLKAAIEASLLDMEEQKKKHSAQIKEQAQISGSRIDKNFILPNKEFSLTPIEIENINLFSNLVDRLQTQPPGAVLKEPQIQELYENISKLRPKLARTYGETMSKHDSLLDLHAKLSSVVRYYDRLLEQRLSNSYSQFAVSRSSSSKRPDSKIYPTVTPDTSRGITENYYSSNFQADRKSYSQLTDIYNQDSSLFVHGEPNSTSGLEPVTVGSNYNHANFGVSNATSGWTAPNESPINSPQFSLNTDKTLYSSPKIQQQAHSMKPVNQQILSEPSKVLPMPSINSSVASFYNPPQSSKIYSSNLQPHLSRPIQPSQSAIFQNGYPKKFTNNPHSPGFHQTSLLQQQHIVPQGYKSSEYQDHAAINHQNSSSLQQTSHQQQATSELQNFYQVPSPQQQQLPSQPHQQLQQQPQSPSQPQNFYQVPSPQQQQLPSQPHQQMQQQQASSRFQKQNSWQHQPDINPNQLRVPSNFSYNPEDIPSPPKHILKQPTVEECLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEA1</accession>
    <name>A0A0B1PEA1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000311">
        <property type="protein sequence ID" value="KHJ35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEA1"/>
    <dbReference type="STRING" id="52586.A0A0B1PEA1"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="268"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="573" mass="64591" checksum="E908858B14FB3381" modified="2015-03-04" version="1">MAIVYIDTDIGVDDPANGSEDQPYKSLAYAYIQENETSHGKTYLSRASITGSIDTGTDPAERLKWKEPAKSALKKAQGALEAHKKKLLKQRQIAAQEAEKEAARLANLKDAGKIVLEEDPSLPEAIKIKISNKDVKLGEGDVKGCRIKVSGRIHRLRVQKQATFLTLIDGYGHLQCILVGNLTKTYDALTFAQGTALTLFGEMRKVPAGQSAPDDRELHVDYYKVIGTSPSDSEAITNKVSSQQDQWEASMLDNRHLVLRGDSASSLMKVRSALEWAFAKSYKELQFTKISPPAFVQTQVEGGSSLFELDYYGEKAYLTQSSQLYLETGLPSLGNVYCIEKSFRAEKSLTRRHLSEYTHVEAELDFIEFEDLLTHLEEIICMVINTVLEDPNIHGYIKQLNPEFKAPSRPFKRMKYTDAIDWLNSQDPPILNEDGKPHVFGDDIAEAAERRMTDIINLPIFLTHFPSEIKAFYMKKVKNDTRITESVDVLMPGVGEIIGGSMRMEGFDELIEAYKKEGIPSKEYYWYTEQRKYGSSPHGGYGLGLERFMAWICKQHSVRTCCLYPRFMGRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEP9</accession>
    <name>A0A0B1PEP9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ndt80 like dna-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000521">
        <property type="protein sequence ID" value="KHJ35114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEP9"/>
    <dbReference type="HOGENOM" id="CLU_019835_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR VIB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="106"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="106"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="411" mass="45151" checksum="772B32B461E7B953" modified="2015-03-04" version="1">MTTSLTLNDTETREEVGEEFSWQDYGTHQPFSTSNPVPFDADYEVPGLPIVYSAKRSRGGYTSIDIPSLNRQSPFLELGEISNLNSFQPSSCLKRTFSHIDMLPFGDFSSGVKEEIPEIPNPNISQGHQLLSFAKLPETHSLINDQGDVQQIDLTAQLHGMFFLSEQAAIPGESIQAKPELTCYRRNLFQISGSVTTPQKGLYYMRGSEKLPLISMEVQISAIESVDGHKVRLIVIPWKTPPPNSPEPTVSLLDREPMPIPITAYKGISDSSRGIACSPIAYRRLQFRVATANNGRRKELQQHFTLHLNVIGTLADGSQVDVCETSTAPIVVRGRSPRNFQSRKGIPLVGSSSSRGNPPKLQIAMNLMASNVLAENSVKQAAKNGAEQSLELPRSEFTFDSNNIPGSPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PET8</accession>
    <name>A0A0B1PET8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative 3 exoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000246">
        <property type="protein sequence ID" value="KHJ35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PET8"/>
    <dbReference type="STRING" id="52586.A0A0B1PET8"/>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="OMA" id="MCCVYGP"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="42"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="33759" checksum="B98541B98F0FB987" modified="2015-03-04" version="1">MDRRRINGPSGGTSAPIYAKSKKIPTLPPLDRPTRTRIPNMLRKMFLKTGVTPSASGSAYLELNVPKIQNSTALSLASLSTSGLKLTCTIHGPRPLPRSAPFSPHIVLSTHVKFAPFATRKRRGYLHDSSERDLAVHLETALRGVIIGDRWPKSGMEVIITILEGEENYWWGDADNQLKIKTDDWGMMSVLSGCITVASAAIADAGIDCIDMVSGGVAAIVRDDQETPVLVLDPVPSEHQDILSACVVAYVPSRDEITNLWIRGEISHKLSISSVGSTHDELIDSATQAALGSYRVLVAALKETADMKIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEV7</accession>
    <name>A0A0B1PEV7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative related to coenzyme a synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000493">
        <property type="protein sequence ID" value="KHJ35169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PEV7"/>
    <dbReference type="HOGENOM" id="CLU_003997_0_0_1"/>
    <dbReference type="OMA" id="HTRWWLT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="771"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1701" mass="190029" checksum="FBDD5365753EE791" modified="2015-03-04" version="1">MDNQQVDLVEDENLALRFLELDNEIVLYDEWIAHFNDTDQSYGCCELLFSSIPKPNYPSLLPATCFYAALKKYHGCWPNMKVINAYTRLKHNFPKPDGSAVNPNLSNALAQELEEAVKEYIKGPTSLFATSDSPALIDPLSERSLSHRELSSFIQNFRLPIKSERLSKRKLTVAIALPNGLSLGLACLAVSCHYTAAPVDISGGPTQLQKDVELIQPQVILSRSQDVKRLGLDKEWVKHNKIVLLVLDEDSNMKFTVRKKEGITIEGIEDCIPSYEEEIAFILLTSGTSGTKKVVPVSTMSLLTGTSCVITSWGLISQDSCINMMPLNHIGGLVRNLFAPVLSGGSTILCPSFDPNLFWDLVIRGQGTWYYASPSMHASILFEKDFRNYLFLKNNIRLVCNASGALLPSLATRLRDAFNCIVLPSYGMTECMPISTPPLNYNLERPGTSGISCGPDVAIFNSKNMPLSTGEIGHICVRGGPTFAGYLKNGMIDTKSLSESGWFNTGDLGYLDADGYLFLTGRSKEVINRGGEIISPFEVEEAIITASNTKSSPLYQRIKAALAFSVPHYLLQEVVGVIIVPYKEKPRPDLRLLQTSLKNDLHNSKLPAIIVYMDELPTNNNKVVRVKLSERMNLEPINENTKFFEKHFDATCPPLNSSLDTQIETTTCSINTQLIKDTISHFIGPETDLFVREQPQNGLAEIIIFHEKEYLLEEDLKKSMFKHMQEHLPGYQVPADIIFLNSPIPRINSISIDEIEVDKIINRNFINDSTLSFSETQLKIISAMSKVLDIPNHVIKLDSDFFQLGGDSLNAGRLLSILRRDYQIQIPIHHLFTTSTVKDLSELVGKLNSMTELQTETDLSSLDVRTTGKEKTHSNTNPILLAIQILPIALFYPLKLAFWFTMFLYTLSFLSRSWRDTHLVARYITLLIAITISSLSCQIAAPVLGIMLKWIIIGRYKAGNYHMWGSYHTRWWIVDKILLVCGKGVFEYTQISMLMYYRVLGASIGSGVVIEPDTQLGEFDLLKIDDNVHLNRCICRPFACESNTQFFLGKIHIGRNCSIGLKSYVAAGSFVPANTYMGPNTSTYEKDDALEDHRGTTNGKLPKPHFLLRLSVIIPLQLIVLFISSLPWMIALIGVVESKPAGNSRLGVLTIIRWWALPRRIAFHYVAALSHVLLSPLVRLASIIFIKKILDKICGRKISRSNEEFTPLEIFRTALMDSLEPNRSFLLATKLFGSHYEVTSIAARALGAKVGKRVYWPGTGPYIEDFDLLDIGDDVVFGSRSYLVTRDGHGSLAIKIEAGAMIADRVVLSPGTIIESRAIMGSGATTRRNQVCPLDSIWIGKKNGSAVCLSQPWTMSEKLKNDTKSSSVSSQNGRYYDLKATTDIIRNKEGSCLDSEFFLNEFKDELPPNKKINSSISNSSVSMNIPTSKSKEKMSPFGRAFYNREAPYYVLPMYIIFLYTMVISAITRIFWDTNVIANLLLFMLIKYTTLLERRPVRSFIIYSFNVCFLSVLLIFKSLLSLAIIIAAKWIIIGRRKPGNYNWDKSSYCQRWKLFVSIESLRTRCFGEGGVLGMFTGTFYLVLYYRLLGAKIGSNTAIFAGGLPSAYITEPDLLTVGNRVSIDDASLVAHINSRGNFDLRLLSVEDGAVMRSGTRLLSGASMGRGSKLLEHTLIMAGDRADDELVFQGWPAEPSKGINKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF05</accession>
    <name>A0A0B1PF05_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sir2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000211">
        <property type="protein sequence ID" value="KHJ35900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF05"/>
    <dbReference type="STRING" id="52586.A0A0B1PF05"/>
    <dbReference type="HOGENOM" id="CLU_023643_1_1_1"/>
    <dbReference type="OMA" id="RRHYWAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="384" mass="42769" checksum="780979909FB498CE" modified="2015-03-04" version="1">MQKPLLKIPYLGPFAPPRIIPSEAHTLIGAVTGLIEFLTAPPPSSIPDNVLDPTSTVLLTGAGLSVASGLADYRGANGTYKVNKNYRPIYYHEFISSHEARKRYWARSFLGWKNLYKARPNVAHFAIKELGKMEIVRSVITQNVDSFHLMAHPKLPTLELHGSLREVRCISCNKRYSRSEFQGQLEKLNPIWKDFFDEALNSEAFQDNGSFRRKPRGFSTNPDGDVDIPGAPYSTFRYPACQNCLSNPLMENDGSRKRVDVDNDGAWQIGSTSGILKPDVIMFGESITSNNKEAAEQAIDNSGRLLVLGTTLATYSAWRLAKRAKDRGMPISIINLGGVRNEEYFYQDVLDSENGTNGVRTELKTDEVLPELVGILKTLGCRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF09</accession>
    <name>A0A0B1PF09_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative spo7-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000210">
        <property type="protein sequence ID" value="KHJ35905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF09"/>
    <dbReference type="STRING" id="52586.A0A0B1PF09"/>
    <dbReference type="HOGENOM" id="CLU_032659_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="47512" checksum="A064EF4BC52EEC66" modified="2015-03-04" version="1">MSNLDQFVKGRSPIIGKIGTSQNGPVLSGKNDLPPTEDSLVSMHSSPPKIYLDLLIMEASLRVQWLQLRTRRRQHTFFLTLLALWIIYFGYALFLSPREDGSGVGGSVYWVVEVVEKLCFLGGIVTGVLVWGTGQWERGIRWPRRWLYFANRGLRVFNCKLVVIKNPWWLEVYSIISFLFSYGLFTRSSRNTYRYADQSLLKEYNKFSRNGSSNVLGSKQETNIEGYQEDLSSGGDYIKLLLLPKSFSAKFREDWDIYRTEYWEKENERRAVIRKALNEREMKMAKQKGGYFWWIGFRGWNRSNSKTNEKTNYSLCKHGSNEREKSRFRSTNIRSTLHSQNSSQDSAVKAEIDSKGYFRGGSSTSKLPGKRRKEASGKHKTQINSSSRSSKIENSSRLSKKSSLSSESCVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF10</accession>
    <name>A0A0B1PF10_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000369">
        <property type="protein sequence ID" value="KHJ35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF10"/>
    <dbReference type="STRING" id="52586.A0A0B1PF10"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_4_1"/>
    <dbReference type="OMA" id="HEQTEHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14738" checksum="7AB918E407BE6958" modified="2015-03-04" version="1">MAGCPVIWRSKLQTTVSTLTCEAEYAALFEATKESAWIRSFLTELGHMPVGPIPILEENTGAIKWATDDAMTSGRRLVRIEYHYIVQEGRSKNIISRKVASEDNAADGFTKPLSAESFKQFIEKLGLKNGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF25</accession>
    <name>A0A0B1PF25_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000205">
        <property type="protein sequence ID" value="KHJ35920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF25"/>
    <dbReference type="HOGENOM" id="CLU_041473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="395" mass="44643" checksum="0677D5BC62B98875" modified="2015-03-04" version="1">MSSNTLCTKCLISQPSANFQKKADSNTFFKTCSSCRNREKARRRNTVQRSPFGPSYLQSEVAEPSNNNQNIGVNDNPNSHCPPTENLITEDINLVYENAGTNGPSISIPDNIISVHCKGCRKNCHPDLFYDPIRNRSFKQCSDCRRRDYNRRHPESLQERPDSRLQHPSALPLNPPTVVSSNAVTDAAYIYCRMCRNNYPSESFANPASNSLYATCSDCRSLQHDRRFPTVFETITNQGLSDIIEEVDEANDEEVEELAANIGMFEIVEEEVINGPVPEEAPFGDDPIFMLSQIHSREFRNHDEIQRRLQADEERNGINNPDGAPQVDDFNIDPFLEELPPAEIDNGNQVERLVQNDPFIEENHHPRANEVVQSQSLLQIDPFLESNPPPQAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFM2</accession>
    <name>A0A0B1PFM2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative survival motor neuron-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFM2"/>
    <dbReference type="STRING" id="52586.A0A0B1PFM2"/>
    <dbReference type="HOGENOM" id="CLU_093937_1_0_1"/>
    <dbReference type="OMA" id="MMSWYFA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="142" mass="15935" checksum="66A9C85DF76C63E3" modified="2015-03-04" version="1">MSASQAEIWDDSALIESWNAALEEYKKYHSIKDNLEITEDKGDIEEKLPSVSEEIASTRFGDVANQDSCDAQPILEAEIIDDPQKESMTPQTHTESNKIASSTPLVPQLLIGQVQDEGIKNLLMSWYYAGYYTGLYEGLQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG47</accession>
    <name>A0A0B1PG47_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zn 2cys6 transcription factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000233">
        <property type="protein sequence ID" value="KHJ35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG47"/>
    <dbReference type="STRING" id="52586.A0A0B1PG47"/>
    <dbReference type="HOGENOM" id="CLU_061619_0_0_1"/>
    <dbReference type="OMA" id="DCPTFTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="274" mass="31037" checksum="4F6DB8057D4EB65D" modified="2015-03-04" version="1">MIVTSPNVPARWRAEFLGHISKMPSPELAFSTLHHNLANDHAPITPRTRFCVYRGMWGELPENPRNPAKLNDRVYQSELLTITTDVRMVKIPDIFDSGSENGKIDMSGGGGPVEAVFWIKEAATQWRFIGEAFVVGNDIDDELSSGAKFVKRSVVERMRVVKASGKENWSWSQELTAHFGNLSPRMRGSFKNPAPGAPISSALDNPELKLGQRINDLHDAEARKNFRVIIIMPKRVEKLDLGSPAESQRRWVYTYNMTRNDDQLDSWSEEECWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH45</accession>
    <name>A0A0B1PH45_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ras gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000240">
        <property type="protein sequence ID" value="KHJ35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH45"/>
    <dbReference type="STRING" id="52586.A0A0B1PH45"/>
    <dbReference type="HOGENOM" id="CLU_1846598_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059648" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="139" mass="15956" checksum="420F020CB2617AC1" modified="2015-03-04" version="1">MPYGIRFVCLQIFQALFQLFSSESQQLLLQTIGNWLWKFYLQPALLTPEIAKVLNKISFGRLFGGENISKNNENEMLGVSSIEIQMKLNPKLHSIENPEADIKAPFMETKRCVLYITRVQTGSNLVEILNTPGNPRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHD8</accession>
    <name>A0A0B1PHD8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sphingosine-1-phosphate phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000185">
        <property type="protein sequence ID" value="KHJ35959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHD8"/>
    <dbReference type="STRING" id="52586.A0A0B1PHD8"/>
    <dbReference type="HOGENOM" id="CLU_019266_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="116"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="572" mass="63772" checksum="1B078A3B9B225F0F" modified="2015-03-04" version="1">MVLKQLKSYNRHSKDANFPKINHESSSSLSSSELLGIEAGLHSSEYYKRILSPWRFRLRQNIIPLIQWETPYLAWLQNKIRMPILDSYFAITANLGTHTFFMVILPILFWCGYTSLGRSMVHILANGVFLTGLLKDLLSLPRPLTPPLHRITMSKSASSEYGFPSTHSANAASVASYALITLYTLEYKPEGLKKVLIWGIACLYVSTIIIGRLYCGMHGFIDVSVGGVIGVIISIYECAYGPAINKFMFQSSWVAPATVALIMLILILIHPEPADECPCFDDTIAFAGVVIGIEAGGWHYANSDWAWNSPVPATVPFDLRQMGWVVAALRITVGIIFIFAWRKIIKMVLLKYLPLLFSKVDDYGLIIYQNYSKLSSLIKSIAPYLKLGSIGSIIYDLSDSFTSVHNLINRFSTNERGKPSIQVNDLLKGSELNHQDSENCNKRCEGLIFQCSSSEIKNHTSLDQTLIREPAIIQGLEAPELFSKLVQSTTKLKPASSTKISCEQNESHDRQRRAKDEEVSTRSAPFRGCNADIITKLIVYTGIGWLSVEINPIIFEMIGLGIGRGGVPSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIC7</accession>
    <name>A0A0B1PIC7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna recognition domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000104">
        <property type="protein sequence ID" value="KHJ36229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIC7"/>
    <dbReference type="STRING" id="52586.A0A0B1PIC7"/>
    <dbReference type="HOGENOM" id="CLU_019467_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="437"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="661" mass="74327" checksum="F6DB73453499D5EE" modified="2015-03-04" version="1">MSDYTSTSKDECVDPFISHTSLSATALPFLPKLPPINSFMKTKFPIPGTTQHLEQIIEANEGVEDFGCFTTDTLQSRNIKFTGGDGYDAVNTIEKKVRPYYKGTHRIIGVFTDCWVRCSNIRDAISTYEIITKEYPEVSPQYVSLKEWTEISSPGVKLNRSEHEGQVVIRLNFPHGVDCKQIERGVRALLEEDGHKLFASQKMPATAAGIFHLIAEFEDCLSAKAAVRRLDRRVVAGCAIVNICLHEPDLVYEQAPDQQCVTPTRSQGIGTPLVIEDMMSSLTMGRFPYVPHDAQITSTFASPVSHAGANSGYIFAPGNLPVISPSSISSDTAKCGAPTSFTGLNNLSRIMTPLGPQNSSDSNLSNSNQMTPFTPQSNDSNLVKRDKLEFSVNRYNLGSRRNSPKVPPYILRKNRQSNGTHNMVDINRIREGVDVRTTIMLRNIPNKIDQSTLKSILDETSHGKYDFAYLRIDFSNDCNVGYAFVNFIDPLHIIEFINARANQKWYRFRSQKIAEVSYATIQGRDCLIQKFRNSCVMLELPIFRPKLFYTFQDPLGRAGQEEPFPASDNPSKLRRSCENAEHVGLFAPNAGAQMRDEQRRRRSQYDRGTSLAQRDAFDVFLPDTWSLGIFENHYDFTSCLCILLFLIQSLLMSLELIINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIQ3</accession>
    <name>A0A0B1PIQ3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">EV44_g1446</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000058">
        <property type="protein sequence ID" value="KHJ36349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIQ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PIQ3"/>
    <dbReference type="HOGENOM" id="CLU_011815_2_0_1"/>
    <dbReference type="OMA" id="QYQRHGY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140068">
        <property type="term" value="F:histone crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010867">
        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 30" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="211"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="28">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KHJ36349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="501" mass="57918" checksum="F6E1D68A6CB43DF3" modified="2015-03-04" version="1">MVTGVKGLDNNVASPTAKKSRASIDTLQIGCIAMVMKDGEYRKAEILSIKETKSGRQFYCNFDNFNKRLDEWVPVTRIDFSQDVEWPSSEKRKESKKAPTSGKKKITINKRGQKQRGRTTSIASEGSIHPWTEFVESQKITPDPEGFDKNVMAIDLTNTPGADDDDAMDIDESVAEAVSAKAKIPEEVSREEEIEKLRVGGSMTQNQAEISRIRNISRVQFGRYDLNPWYFSPYPEEFTHEDLIYICEFCLCYYGDIKSFIRHRKKCTLQHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTSRDEKGFHLVGYFSKEKESADGYNVACILTLPQFQRKGYGRLLIQFSYELSAKELKTGSPEKPLSDLGLLSYRQYWTENLVRILLEKNAKNETVSIESLSQELAMTTQDVESTLQALKMQVYHKGEHKIVLPSHVIRKHDAMIEKFKSKPRRQIDPSKIHWTPPVFTASSRTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUF5</accession>
    <name>A0A0B1NUF5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005851">
        <property type="protein sequence ID" value="KHJ29997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUF5"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ29997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="238" mass="26111" checksum="1A30F73606DB3156" modified="2015-03-04" version="1">MIDAETDRLIAKRLKDLYWATPQAQAASSTKATTDDLRQSIVTIDILTPTPEPESRVQKEKGIAAQRPITIDLTASQISSPSLSKSISTTEPQVSLNINEKVKEKTYPPELQVIVEAEKRRAAQTAANLEVCTAIFNGVEIALLPLRVKTQIQFVDTLKIYLRAVIAQFMQSGTKAIPPVLPILPTGPTPAVPLKKVITSLLSLYILANILINPADKVEIFTFTRCRCERPACSALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVS0</accession>
    <name>A0A0B1NVS0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative egh16h1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005363">
        <property type="protein sequence ID" value="KHJ30068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVS0"/>
    <dbReference type="STRING" id="52586.A0A0B1NVS0"/>
    <dbReference type="HOGENOM" id="CLU_047729_4_1_1"/>
    <dbReference type="OMA" id="TMTFHQV"/>
    <dbReference type="OrthoDB" id="5310497at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061513" evidence="2">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="344" mass="35138" checksum="4F196C20581D4E5D" modified="2015-03-04" version="1">MQYSSIILIAAYAVTNVLSHGVIDSVTGANKVQMPGLGVIDDTPRDCASPRCGSEADTSIIRDRELGTNKASALGRTQGGGPVDASKMVALFMGSGGNSTATKKAREVHAANMMRRSLAVRAANGGTKTPKGSKETGVKAAAGAGASSGLPTAADDGTVTMNFHQVNQDGAGPLTAMVDGTSGGTDKAAFQKATVTKNVPGIGIGGLSAASVMDFPVEVKMPAGMTCDATVAGVDNVCVMKLQNKAAAGPFGGAVAFTQTPAAKKRAIEYNLKKRNFARALNQKRQQDQDVTEILAALEATGSNSKAEDGKSEKELSKREKDEVAAALAALKSMGSATTENDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVX5</accession>
    <name>A0A0B1NVX5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005032">
        <property type="protein sequence ID" value="KHJ30128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVX5"/>
    <dbReference type="STRING" id="52586.A0A0B1NVX5"/>
    <dbReference type="HOGENOM" id="CLU_552301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="57278" checksum="FC2A065BDE6C768A" modified="2015-03-04" version="1">MLRSSLSRKLSITLAGNHLLPDDDFREWVHKVIKVTQQIEMTETRFNNSQLLEKYDDNQKLEKSHLSLNLNDHKFSKENESKQAIYQPGGIDDSGDTVMGRINTAGVVKGERRRALWKNKAQIDKLRAEKKCFRCKRRGCTSGKCPLLPAIKPKNKKINAHSVILADIDPALYTLDKEYRKKWLGDQDAVIHSKEQRLDLRKKGISISSVQKWRNDLRHVPRPKNTTAKDMAALLKTVPVCEATIEDISKSLRDKPKLSAEQATLRLPHQIRDFAELFADDKGAEDFPPLRDHLDHAINLRHEENETFTPPWGSLYNIFCVDYRGLNAITIPDRYPLPLFKETLRQLSKARWLTKLDVKTAFHKIRIREGDEWMTAFRCRLLLFEWLVTLFGLINAPATFQRYINQQLREHLDLNAKAYMDDILVYTDNEEEHHWKTVRSILTKIKNAGLFLDIDCYKIGSRWYYGMSSKTELQWAVDTTGKNSSLNGLIKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWD4</accession>
    <name>A0A0B1NWD4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWD4"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="22286" checksum="853D9250B21A417D" modified="2015-03-04" version="1">MEVSSAMLIEEVERVTSIRPAHVKLFGRNKAEAPHRTWMAYFSKAPRTGFRVFDESGIARPFKKQQPIEFCKRCNGHHSTKNCSRAPSCGNCGSTNHSKELCMAATKCRNFGGPHRSDSRRCLACPTRLGAPTKKQMKTFRQVGEREYQAVLRAKAAEESANSAENINIDFTCSQDPEVDGDIDNIPASPIENSTGDAIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWS1</accession>
    <name>A0A0B1NWS1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003644">
        <property type="protein sequence ID" value="KHJ30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWS1"/>
    <dbReference type="HOGENOM" id="CLU_035633_2_0_1"/>
    <dbReference type="OMA" id="AWGFEDP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="37021" checksum="40B9BBFA954793F1" modified="2015-03-04" version="1">MQELQSFYTQLSCQDTIPTERDVEKFFSKCLIAAQSLSVNFSCSKLSKTESASALLALNHSKPKQNIFQASSKIESMIISISELSFSIIKHPNVFFSPKVLKMYVAVQALLGWPDTLPEALHLYSRKPVLLKNKKSLRYSKPNPNILTNAIPPDIAKAALEVAIKAKKLVVAIDIIEAAYTCKVYKSSKFVRQALVPTFLFTITPFAIYTLASHFSNWQTSMDAHTARNVAFLGMMAYLGLTGTVGFIAISTSNDQMNRVTWAPGVPLRQRWIREDERAAIDLVASAWGFRESWRRGEEEGEEWDLIKEWVSRRAMILDRVELMEGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWT9</accession>
    <name>A0A0B1NWT9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004253">
        <property type="protein sequence ID" value="KHJ30438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWT9"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058748" evidence="2">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="34932" checksum="34A174C51A90A866" modified="2015-03-04" version="1">MRQRRERAWHARILICTCVISNIDSTLADFKDEILKEEAAALQIYLQQAISKFAAHDSSPTPSPIPSKFQQKKQSGIHNIDLPSKPIAATVTRNGQKKARVINDSTTKSAQAKNANHIDHLNEPKVTNISSRRQLRKGKPISPIKADKRIFLRLPHEHEWRNLSPAGTREIIVKKLAISPASIGRIKLVHTGFALSPCNDNARKKILEGQHGLFMTGAKLEPATNWVSVIVPTVPAYIRTLQGKVEVSNTMLADEIERVSLERPSFLKLYGQNNPVTPHRTWMAFFPKAPRPGFRVFDESGQQCLTKRKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWW0</accession>
    <name>A0A0B1NWW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003563">
        <property type="protein sequence ID" value="KHJ30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWW0"/>
    <dbReference type="STRING" id="52586.A0A0B1NWW0"/>
    <dbReference type="HOGENOM" id="CLU_072377_2_0_1"/>
    <dbReference type="OMA" id="RLVFKPW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="25057" checksum="BCF4189C7C0EBF0B" modified="2015-03-04" version="1">MSTHCHDEHSEHSGHNHGHDSHDHSDDIQPALQYSLYQYINFDNVTCLNETVAGSGQAIVKKPWAERLQLFPVLVSDTDEQLLMHIPFTGQIKLHSILIRSSNNGSAPQTLKVFQNRDDLDFSTACELSPVQEFKIPQSSEVQDIPVKRALFGKVQNLTLFVEDNYGDDNTKITYLGFKGDWMQLGRAPVNILYEAAASPRDHAVKGTITNQIGNCLGGDRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY28</accession>
    <name>A0A0B1NY28_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2593</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003041">
        <property type="protein sequence ID" value="KHJ31267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY28"/>
    <dbReference type="STRING" id="52586.A0A0B1NY28"/>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="OMA" id="MCRVRPP"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="499"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="377"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="591"/>
            <end position="598"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="843" mass="96079" checksum="70856E8723455BAD" modified="2015-03-04" version="1">MNSIITTHKMEIDVNSHRSQLPQPKKFTTSSNYLSEVSDSQSNIRCKQNSSPAKSNLKHKMISLHEEPAPKRKITKERTDESKLIAPDMSVGIRSHPKAAAHNRSKSGLIREKLTFNKSHGKSESISDISERNLSRSVGPRSRPAFPQIRPQSSFSQSTITRPVSIVSRAQSLLPTGQRGDDVEIVSSESKREEWDVKGRIKNMEVQFLEMRETIKDASIDKKSLEESMITLKARNTELEANKYQLETSNRMLQSEIDLIRQKAEVSQKQHIDATNTLHEHIRSHQLEIEEIRRQNRHEVEKIRRDNADEIDRLSRENRDQIREIERKSFAENDEKLREFERQNLGILEDEKRKNFREIQTLEAKYASENAKQSLVIQEKTLEMKNLHSELNDIKEKLDLEKFEKAKLQNELLSMREGYQKIINENSSTVQNLEHTLASLRARIHFLESGSKAQSDSFAEMESRLEKALNSARESKEKLVKEESLRRILFNQVQELKGNIRVMCRVRPILNDIEGDAAKFKITDADKESKELEVIGKEEKSFTGNITRKKHYFTFDRVFGPESQNQEVFEEISQLIQSALDGYNVCIFCYGQTGSGKTHTMSSPDGMIPRATKQIYETATNLKEKGWVYNMKGNFVEVYNEEIHDLLTDSKEFDKKKHEIRHDDERKQTIVTGLNTVALDSPSSVEIMLERAAANRSVASTKSNERSSRSHSVFMLKIMGQNTSNNESCEGTLNLVDLAGSERLKQSGAEGDRMKETQSINKSLSCLGDVIGALGQGKGGAHIPYRNSKLTYLLQYSLGGNSKTLMFVMASPLEAHLSETISSLKFATKVHNTHIGTAKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY73</accession>
    <name>A0A0B1NY73_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative involucrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003021">
        <property type="protein sequence ID" value="KHJ31287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY73"/>
    <dbReference type="HOGENOM" id="CLU_006409_0_0_1"/>
    <dbReference type="OMA" id="IDDYEVM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="566"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="782" mass="90431" checksum="C44DEA76943D90FE" modified="2015-03-04" version="1">MISGSPANSQAPLLAPNPRIDSSPLDNSKQEIYTTKLHRKTNDNRSQDGNYFASAEERVNGLQEPSANLALKSYRKDIMSGIKDEKWWLIESKGSPQENSSIIDSNNPIQTLILLETALNDSKNYEILSPEEVEEMKIKCESITRQIKKTRQDLVIQSKYSDATDIVTKLYSSNSSTEVTPENLIVQRDDQVRQHEREFMESERRCEELAINLFRLEKELMITQGRILRHTSRILQLNYEDAQIVRKSTDKSEDTSKSTNKYNITQFIDDDLLFDERSLYRALEGLGGETVMTEMVSEQQVEMIKRTEQKLVALNHRIMKIIKKLNGETENKLELPPSSNDNKESLEILQIHLGFLEENITTIDFEQEKLKNQYNKIASQNKYLLDEKEKLQRQIQQYLDQKSISNSSREAQRNIKIDELPKRNEPQATNLNDIDNLREQVNSLNEKLVKVRQKEIFQKKLESEESSNYLREADKRIQLAEEKLLIAEERARSAEESSCVALTEIKNRDQRISRLEEQLQKSEINYAATYAELESKMDRLEIQIKSLENELASVVSAKAELDKVVKENETILESKDKETNQAQMDIARLQTELTIAKADLDIAYGSRAQRAAQMALNPIAQSEIDRLKSINDLQVSEIIALKENLADASARADENVKELRKELTETIEEYEKMTKASIEWEKEREQLEETIDNLREAKEKVEAQFSDEKVQWIGIRSPNAEALSPNTTTTTILKNEFKKMIRDIRAENAKVLKAEQFERRRLEEELRSFRKTRFSPNSLNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYF4</accession>
    <name>A0A0B1NYF4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003353">
        <property type="protein sequence ID" value="KHJ31008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYF4"/>
    <dbReference type="STRING" id="52586.A0A0B1NYF4"/>
    <dbReference type="HOGENOM" id="CLU_036531_0_0_1"/>
    <dbReference type="OMA" id="RESAMWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="32295" checksum="6D81989F62D38490" modified="2015-03-04" version="1">MTPEVELKESTSTSEYDLRAEATNRSGNISSRVKLSDGNKEQDTTCYARLVPESPSYFSVQPKFMDSLISLDQILEKYKTLPLSAPGDTPKTSWLSVQNYRDMVGENVKNTRYQHVVRVLKRLNQIHPLYMPEEVQNAIQIFKRNVVKETASTIKSPIDKLGRSLGVGRRKTATGRAWLVEGTGEVLVNGKTLAEAFGRIHDRETVIWPLKSTGRIDKYNLWCRVEGGGTTGQAEALTLAVAKALLGHEPALKPALRRAGCVTRDPRKVERKKPGRLKARKKPAWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ05</accession>
    <name>A0A0B1NZ05_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mba1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002709">
        <property type="protein sequence ID" value="KHJ31637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ05"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ05"/>
    <dbReference type="HOGENOM" id="CLU_055139_1_0_1"/>
    <dbReference type="OMA" id="QYCKREN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33036" checksum="A044A6FEF6619D7F" modified="2015-03-04" version="1">MAKLNRRSEIIFKGILIFPYSATRCLTTLPPLMKLQSSEVGYLKGARTAERSLRVMSKENAKIPLDIGLLEKTFITPTGLNRPSIFKSPSAVLAIERIRLLSRFRDFLSLLLCKFTSPKVKGFWNRSFNLNRSSLVPTAIALHRQMYTAFAEADDITLRNICLDGINDNFRNRIAHRPREEKVTWELLKYSKTPKLISNRAAKTPINGMILRQAVVRICSKQKLTRYTKIRGTTKLEQIKGSGKEKDVVEYIVIQRVYEQWKPQNWMIWGTAQETSLEDLEEWKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ30</accession>
    <name>A0A0B1NZ30_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002689">
        <property type="protein sequence ID" value="KHJ31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ30"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ30"/>
    <dbReference type="HOGENOM" id="CLU_1448742_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="187" mass="20588" checksum="953E76A4F11F59B4" modified="2015-03-04" version="1">MSRVTPVARVAQTSRTVSSYGNIAGQKNGFRNTSMAIYRGLKDTKVDRMTNKDVTSFSYILRDHLPNIELKGSQATQGLHTVHRPTVSSPYKIVPMMQVFRNSAPKNAFHGLSTIDSHMMPSLKSPPPPPAKLRVPLLPDNYKPDRSLKTGHSLEISDDAVLKPEISIVAHHFEYGAPVPIGESSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ53</accession>
    <name>A0A0B1NZ53_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003062">
        <property type="protein sequence ID" value="KHJ31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ53"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ53"/>
    <dbReference type="HOGENOM" id="CLU_054409_0_0_1"/>
    <dbReference type="OMA" id="WIGHPPT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="157"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="312" mass="35517" checksum="3A3FED1342B9F7ED" modified="2015-03-04" version="1">MNYLKTSRLYTHQKLNLKPLKTLFATSNSVNIEEFQQKAFYPELPLLLSDNANITDTISQNLSLPATRKWFTNSVSASGERSVILSREYLNPYDSTILPYEMMGPLHKSLINLLRTIKGADGFAGCTEQFHQFQAPFALMLNCRIKGLYIAQAPLTDLPSQLQHDFPTPRIVAKAGRGDIYNANIWIGYPPTYTPLHRDPNPNLFIQLIGIKKVRLFKPDIGLRIFQKVQRNIGEVEHNGVIRGREMMEGAERKELEKIIWGPSVDYSLDGMEVIVKSGDSLFIPKGWWHSIKGLQDADPKGINASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ61</accession>
    <name>A0A0B1NZ61_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004577">
        <property type="protein sequence ID" value="KHJ30285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ61"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ61"/>
    <dbReference type="HOGENOM" id="CLU_000384_6_8_1"/>
    <dbReference type="OMA" id="PRHEQEF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="197" mass="23079" checksum="6A5F8D99C285D77D" modified="2015-03-04" version="1">MAQVAMAWRQQLMEDKSNKNRQQQEIFKIGDRVWLNLKNITTPRPSKKFAWLHSKYKITKIISPHVVELDIPIGIHPRFHVDLLKRAANDPLPSQKQEDYQPDAIDPKIPRHEQEFEIDRILRATTRGRGRGIQRLVLVKWKGQAEPTWEPRSSLQETEALDKFEELYGTSDDVGENIGMQTGRFLRSMKKKKKNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ89</accession>
    <name>A0A0B1NZ89_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005693">
        <property type="protein sequence ID" value="KHJ30006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ89"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="37137" checksum="136465C9028BDB38" modified="2015-03-04" version="1">MAKSIQAYLRNAISKFAVSDTTPQIPEKQLKSNTTKVSENSKAHLPNKPLVTPFPSKISSGQVGNMTNSTKDSRSQNPSGLENSWSTIARNGHKKSRTILTSRSQASQASKNSVQTTLVDNNIATAKNKDAAGNQQDNRLFLRLSVDHECRKLSPAGVREIVVKRLSISPAQIGTIKPVRSGFAISPRNNFTREELLKAAVRLSSADVKLEAASNWISVMIPTVPISISTEKGRIEITKEMLANEIERVSSMRPASLRLYGRNLPNAPHRTWMAYFTKAPRPGTVQESLPVEIVARHCTLKTYAWPPPNVKTVEVHTVPIAVGVWLGPHVTESPQKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN1</accession>
    <name>A0A0B1NZN1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative rnp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002574">
        <property type="protein sequence ID" value="KHJ31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZN1"/>
    <dbReference type="HOGENOM" id="CLU_012062_9_0_1"/>
    <dbReference type="OMA" id="MHGKDVN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="256"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="405" mass="43733" checksum="4FCE79284DEB18AA" modified="2015-03-04" version="1">MSSTMNNVTDSINDVTATLGKVSISDDPAETDQATRDSHKEALLASAAEGRRLYIGNLAYATTEGELQSFFKGYSIESTSIPKNPRTDRPVGYAFVDLTTSAEAERAIAELSGQEILERKVSVQLARKPEQPADKATSNGDEVGTGGGTENENRRRRISGRGRGRGRGRGRAGRTGRDPPNSQDKGTEVETTETPQIVATTSETVENQPATDKKDEIEPKDQKEPTEPTEQREKPSRPPRERRERGPPANGVPSKTKVMVANLPYDLSEEKLKELFADYEPVSAKIALRPIPKFMVKKLQARNEPRKGRGFGFVNLASNELQNRAVAEMNGKEVQGREIAVKIAIDSPDKTFEELTTHVSDGAGEVSNVGNSTEGTNGAIAKGITNDKLQSEGLAGTAETVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS6</accession>
    <name>A0A0B1NZS6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01002534">
        <property type="protein sequence ID" value="KHJ31857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZS6"/>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="33259" checksum="0976E823DE7AF2B7" modified="2015-03-04" version="1">MTKRVKKVTLLTQGRPPIFKTKKSLSSKVTRRIIQNHHNLEKERSKALANGDSAKATLLLEQIESQGGIEGYQMASLLGQSRERGGDSSKLLLEWLKPVTTELRESIANGNPLRLLEIGALSHTNACTTCNLFEVERIDLNSQSKTIKKQDFMQMPISHDEKNKFDIISLSLVLNFIPDATEKGNMLLRTVKFLKTSKYSGTDEYVRLFPCLFLVLPAPCVMNSRYMNNTRLKEIMKSLGYICIKYKLSKKLIYYLWRFEEIESTTVIQKFRKQEIRGGKSRNNFCILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV0</accession>
    <name>A0A0B1NZV0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative bzip transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005117">
        <property type="protein sequence ID" value="KHJ30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV0"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV0"/>
    <dbReference type="HOGENOM" id="CLU_102236_0_0_1"/>
    <dbReference type="OMA" id="HPIERSD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="152" mass="17239" checksum="71887D6C8F3BE1D7" modified="2015-03-04" version="1">MSDSGATSSHNSSSRQTIDPEIHDPKSSAGYDTPPSLRPQLTTRKSSGTIIVPREHPHVELHEGEEEFDEDDARAMSPRRNSRDIEKMSEEAREQLQQHAKLLQKSLLDIFVRIEAVKEEHDKLDNNNKFLQKYIGNLMSTSKITSSGTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P007</accession>
    <name>A0A0B1P007_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004936">
        <property type="protein sequence ID" value="KHJ30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P007"/>
    <dbReference type="STRING" id="52586.A0A0B1P007"/>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="750"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="833" mass="92967" checksum="F06848C53EBE09A6" modified="2015-03-04" version="1">MSFYASQGSQPNGVMMQLSSSSRQFEGAPGINPVDNVPQIYTAVYSTVEVYEMEVNGIAVMRRRKDSWLNATQILKVAGIEKGKRTKVLEKEILTGEHEKVQGGYGKYQGTWVKFERGFEFCKQYGVEELLRPLLTYDMGQDGSVAGGGAIDTPTKEQAMAAQRKRLYNASVESRPSSQSGVMLKNIISTASHAVAAINKARFDSPGPRMRNSNTSRLKNLSKNSLRQQQQQHLNSQSSSFSTGITGLEQGSNNFHSSENFSRGHEISSCANSFTQQTRDNQNPELDEPPRKRVRPSPNMISPHPKIGEEHNSFPMRELTPSRLNQSLSQHSQQDQFTNSLILPLPPLQAPINTQLAAKKDLLMSLFTSDVQKDFSKHKAFESLDPDDLDIPIDASSNTALMWAATLARVELLGNLIIRGASIFRVNSAGETALMRSCLVTNNLEAGSFPKLLELLSPTIEMRDSKGRTVLHHIAIASAVKGRSQASKYYLESLLEFVVRGSNTTNNQKQITNGQRASQSIGIGRFMSEIVNMQDSSGDTALMIASRIGNRSIISQLIEVGADISIPNKSNLTPADFGVGDVRELDIRRGDRTQDDIPLSELKENSKDIISSITNLLEETRAEFSSEMNKKQAIIDDLHSKLRNESSILGQRRRLFETLQSEQNEVETRNFKISNLCKALNEEKSKLSQLSQQQNQKEIEELFKLGDADKDFKIPKEALETISSFNLKENLLPLMTDDETKRIDSLLPSLSVLRARVNAYNSINKDLEKNVLELKSKDSELTRKYRKIISLCTGIEEDRVDDSISSLVRSLESEHDDVELSRVRKFLSRVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P089</accession>
    <name>A0A0B1P089_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative exosome complex exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004664">
        <property type="protein sequence ID" value="KHJ30244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P089"/>
    <dbReference type="STRING" id="52586.A0A0B1P089"/>
    <dbReference type="HOGENOM" id="CLU_010129_4_3_1"/>
    <dbReference type="OMA" id="TMDIIWL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="453"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="615" mass="70437" checksum="4D1776F8E53123AF" modified="2015-03-04" version="1">MDASLDFKTLQNQIQPGLLDITRTVGRITAEDLTFQRSLNREVRTVLDEQSERLLSLASALIKSAASISDLRSPILEDVEDVENNWRSVVDVVDSLLEKSDSCLDEYTGLIKRNDTAESNLKNEPHPKSKKQGSVLDQNLRTQNIVKPQLAFEKKPDNDDKTPWKPFITTKPHAIVSLEDSLELFVNDHNQKQFRHPYEAEILQLKYPKFVYEKSEPIQYTPIQDSSVIFVDTEEKVIEMLEDLKNSKEIAVDIEHHEARSYTGLLSLMQISNRTKDWIVDTLKPWRHKLEVLNEVFADPRIVKVFHGAFMDVIWLQRDLGLYITGLFDTYRACQVLGYPAGSLAFLLKKFINFDADKAYQMADWRIRPLPEKMLYYARADTHYLLYIYDQMRNELVEKSSHENAKENLIDAVLQKSKETSLSRYERQIYNTETGKGPGGWFSLLLKTPAMFNKEQFAVFRAVHAWRDKIARIDDDSPSFLMPNHTLFSIAKIMPTDLLSLLRTAHPVSYGVKSRVDELLEIIKLAQETGHTGPSITDFLRPRSLKASSQAAMLATPQDSQVRNVKVVPSDGELRSIDSSFWGSAFGSSMWDVPNQDHNDALYRVYSVASVNSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0A2</accession>
    <name>A0A0B1P0A2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003709">
        <property type="protein sequence ID" value="KHJ30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0A2"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="17900" checksum="A53E096806D0C776" modified="2015-03-04" version="1">MAFFSKAPRGSFKVFDESGVARPFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHSEDLCMAVTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQLKTYRQAGEREFQALLRAKAAEEFAATVESTNDNLISSQVTEPKSNIDNSLAPSVDNSTDDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0D9</accession>
    <name>A0A0B1P0D9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor tfiiib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002326">
        <property type="protein sequence ID" value="KHJ32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0D9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0D9"/>
    <dbReference type="HOGENOM" id="CLU_022548_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="380"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="491" mass="55613" checksum="56D683C8390B2BCC" modified="2015-03-04" version="1">MIKGRSKVFAPKKIIRNSQSSQPISGRGTEVLVKTHTPVLEDKRCTTDPQDKNLNSIPDESELPIDKPIQVSGYEATESRDNLEGQVSNLSSQSDSNRRHQNDRTQIESTENIAPHSRCLQTISVSGSTASDNLSPIRNRAVNKSQIITSHPSPSTSQVDLNTVGAIENNTTSVETLKEISNAVKAPAVAKAKRKYTRKPRVLEGEALIEDTQNNLKKSNEKKKTRVKRKRRENTPEGAESKKIDPSVITMQDLCHDLRIGKKSRNHDEIMGRLARMKQNAIKARMKRDNPELEDYIDGKSGDNYTLNESRKTEPSLNSQIAPPSAPPVGPKIRIVDGQIVFDEQSLQIDRHKSARENFFAAEDVVEENDFTRVVSCGDYLKRERSQHWDIPSNELFWKGLRMFGTDFEMIAKMFPHRSRRQIKLKFNAEERSNPQKVNRVLMGIKTEEIDLDEFQRLGNLELEDLADIKAEQAQVEKEQSERLKAALENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0N5</accession>
    <name>A0A0B1P0N5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mitotic apparatus protein p62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004140">
        <property type="protein sequence ID" value="KHJ30486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0N5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0N5"/>
    <dbReference type="HOGENOM" id="CLU_044616_0_0_1"/>
    <dbReference type="OMA" id="IQLFDWS"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="377" mass="42351" checksum="DCE31A03BA73A02A" modified="2015-03-04" version="1">MDGKNLIRIPCSSKDEHEFVLIHASYAPEKDYPLCLKLIGSEGENVYTTTIQNGENPSGITWRNYVPQPNQKLVNYILSSIFLNGYVDAIADASDVGKTLTEKFHAIANIKSDAIILTIHKKAENITEKIGDITLLSDELDISLFDWCNTIIQLRDKSQFELSVLRSVVAIKDNEIKKLKETLDQMIKLKGDHENELMEKFALLLNEKKIKIREQYRSLQLDSIGNSKPESRKKPVGPEQDKSNLLLSEQAFTSRRKRKVVQANSESEFESEAGSKNNLEDTTFDDFDKDSKVTSDATETETDDEEFLASVAQKNQDSGSISDMTQESSPATMTEEVILPPKRQLPFAKDTSATKSKMPKSAVDFEDVAEVDSDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S8</accession>
    <name>A0A0B1P0S8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003490">
        <property type="protein sequence ID" value="KHJ30885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S8"/>
    <dbReference type="HOGENOM" id="CLU_102310_1_0_1"/>
    <dbReference type="OMA" id="MYVSHIP"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="109" mass="12830" checksum="0A13A803626ADD5D" modified="2015-03-04" version="1">MKINPRSLMASSINSSNHGFNATPMALLPPIPLYRRILRTHRKHLPKQMRLLGDEYVKKEFRSHKNIENPIHIIGFLKEWQMYAQKLEGNEWIGERMDPAKIEKMSGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T0</accession>
    <name>A0A0B1P0T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004268">
        <property type="protein sequence ID" value="KHJ30429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0T0"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="267" mass="29892" checksum="8A0763434A4AC4E3" modified="2015-03-04" version="1">MYKRDIEEQEAKHIRDYIRKAIARLAASDNSPKPPLILMNTKPRQTKDRCREKDSEKKNNLPSDLNKPSNDTPGQNSWASAARNGHKNSRVTITASIVSKNITPGDSNKPSTSSKLTMIKNTKSRNSKEIISDSRNFLRLPVDHEWRNLSPEDLREVILKCLAVFPASTGLIKPVRTGLAISLSNSGTREALLQTKIGLLDTGAKLEPASNWFPFLVPRMPKFIRTIQGQIEVTKEMLYSEIERVTSTRHTSVRQNGASITGAPHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T1</accession>
    <name>A0A0B1P0T1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004052">
        <property type="protein sequence ID" value="KHJ30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T1"/>
    <dbReference type="HOGENOM" id="CLU_1266671_0_0_1"/>
    <dbReference type="OMA" id="WAIDAVW"/>
    <dbReference type="OrthoDB" id="3583007at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="24061" checksum="7E4D637C328BD2B0" modified="2015-03-04" version="1">MASQTAATKLILSNANPSTITPNVNPDFLLILIESLNLHLQYPIEYTNNPTSDTDYLISQLGALTRDLFYKAFSYAFIDYPSPRNISRPCIPFVFTEFISCPQSCPQLIEAHINTRGLQATRIPRAYAQIIASDLYENVKKCFQSPPTKGWQTTVYHRVYGENLGILANWAIDAVWVWQVVTAVDWNKTKPTQRSFLLLNYAGVGYATKEMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y0</accession>
    <name>A0A0B1P0Y0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003948">
        <property type="protein sequence ID" value="KHJ30576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y0"/>
    <dbReference type="HOGENOM" id="CLU_1769468_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061707" evidence="1">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="147" mass="16957" checksum="51EA938BCFA8BA61" modified="2015-03-04" version="1">MLLKILTIICLFISNICLAFSPISLTIKWESRKADCQGIRFDEIVITKTVVDACEKERSSIVNVGYGGIFGTFITLQNYLYNREVYSKNGEWGPEPVSLWIIHPQRLPNSNSFRAAIRWDKDTETCHYFGIAMYDKSKKNLWPCHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y5</accession>
    <name>A0A0B1P0Y5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">EV44_g3062</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="JNVN01003939">
        <property type="protein sequence ID" value="KHJ30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Y5"/>
    <dbReference type="HOGENOM" id="CLU_006515_2_0_1"/>
    <dbReference type="OMA" id="QTHQFRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002774">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 26" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="12"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KHJ30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="897" mass="101782" checksum="233684F8C10D2101" modified="2015-03-04" version="1">MKEIKEDGDENICRDFHHPYEPYTIQKDFMETVYDILENEGVGILESPTGTGKSLSLICGALTWLRDHKKKAFEKSIIEHIKGTEGEPDWIIEQAKAQRCRELFAQREELETKLAQIRLKEKTQRDQYLKRDKTYIISKKRKIDLSPDSKFENNENLYVLDDYESDQDQLNSYASDTNKLMNFGSNLYSAETLALLNKLGINKSSNFETENEQDIEDEVKIFYSSRTHSQLTQFINELRRPKFPSSISEISNQECSSQDGSDIESVKHVTLGSRKNLCINPKVHQLGSLTSINERCVELQQSSTPKDKKCIFLPNQENQPLVHTFRDHTLAGIQDIEDLSTLGKNIGICPYYASRAAIKPAEIVTLPYPLLLQKSARDALGISLKGHVVIIDEAHNLMDSISNTYSTQISLKQLRRAREQLGIYLQKFRNRLKGKNRVYIAQVVRVIDSLSRYLEKQFANSGNDGVVLEDELLSGKGVDQINFFKLIHYLQESKLARKVEGYTRFKEENEKVPQAQRSSLSANKPDDSGPVIHQLISFLFALTYPQNEGRLFFSKKPPDQITLQYLLLDPSTHFQDIVSSTRAVILSGGTMSPMSDYNLHLFPYLEESRITTLSCGHVIPKSNLLAWNLTKGPSGQDFEFTFGHRNNDNMIDDLGRSILNICQVVPDGVIIFFPSYQYLNSVFTRWATDQKSGNSLLKRLETKKQVFQEGKDVSVDTVLQNYAQAIDSGKGGLLLSVVGGKMSEGINFSDALGRCVVIIGLPFPNINSAEWKAKIEYIENSHKKQLHAQSSKSKNTIEKGIPNTEKVESKTKTAKDVSREYYENACMRAVNQSIGRAIRHKDDYAAIVMIDKRFRNNKIRNKLPGWIKEGLVADSGEMSFGMMMGRLGTFFGSKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z2</accession>
    <name>A0A0B1P0Z2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003413">
        <property type="protein sequence ID" value="KHJ30960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z2"/>
    <dbReference type="HOGENOM" id="CLU_041473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="438" mass="49009" checksum="B21F10E212AAA5B4" modified="2015-03-04" version="1">MAAIPDQCEPNNEVIANNNAPDIPSVNNENLSIEITNTAREIAVHEDNTLNITCNTNTTFCKGCRKNCHPSLFYDDIRNKSFKQCSDCRRRVYARRHPEMLQPQTNSEHLLPTGMPINLPSYNAVNLVTDTAPILCRKCKKTCPPESFANSSSNSLYATCLDCRSQQHERRYPTVFEPTSLQHPINNNDDLYDVSDDDVVNLAADIGRFELEEVEVFNGPVPEEAPLGDDPIFLYSQLQSREFRNHDEIQRRLQADEEINGINVLEPDSNIDPFLEEIPQPGNDLYEDNNQLENLDRNNLFIEETPRPRNNEIAQPQNLLPIDPFLVSYPPPQAEDVIMIDDHQPPAERSEQVQAPPRRIPTWLAAPGARRLDPAGYLSRYRSTMAAHDLGEMNSICPSCKALHFSSERVKGRTGRSGSHSGAAGGLTPTVDLGGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B8</accession>
    <name>A0A0B1P1B8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002102">
        <property type="protein sequence ID" value="KHJ32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B8"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="137" mass="15216" checksum="9BB0C4505765A234" modified="2015-03-04" version="1">MALFAKAPRPGFRVFDDSGLIMIHKKKKPLEFCKRCNGHHPSKNCSRAPSCGNYGSTMHTEDICMAATKCRNCGGPHRSDSRRCLARPTRSGIPTKEQLKSYRQAGEREFQAFARAKKADLKAATAEESILEVDSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P200</accession>
    <name>A0A0B1P200_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative low affinity iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003433">
        <property type="protein sequence ID" value="KHJ30946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P200"/>
    <dbReference type="STRING" id="52586.A0A0B1P200"/>
    <dbReference type="HOGENOM" id="CLU_028340_0_0_1"/>
    <dbReference type="OMA" id="RECYADY"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="509" mass="58190" checksum="47E63308FF2B3F92" modified="2015-03-04" version="1">MSLSIFKKILHSVFPERTDFFAAATTQELTRQEVQNAPYPRSQNNEKDEKSTTDQVSSRDELSSFRKPNIFDQITVLAGSSMTFLLMLFLVGVWISFGIVYGITDKWQIVFQNASSIQVYVIDILLIRQQQNASRALMTILAEFHSRRLTLERLLNQIPGCDRDSTKKEGPRQLYINGKPFNDESDEKMLLPPESMSSISYAWSQTCLLMARGLGSMWTFFLYWIGIGAWVAVGPYFQFSDTWQLYINTITALVLTFTSVFLQNIQQRQEDKLKRCLEHTQKIDAGIERQLRILTGDQRPNEIYTIPEVKRTHFERFNDFSADLMGSGLGVFLSLHFVGLWLYIGPRMRFNDNWWLIIGTFTGLVGFVNGFILRSLYYREETTVKEEFKKLAAADRLILDQLNVPTHVPVQNKSSFSERITGAISDACGHRYAPFGSIIVVVILLAIATVMRWSVTGQLLCNTPTMIIEGFLLIILINAHNHANDERDADFSGLLKRKLLLHGFVETVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P224</accession>
    <name>A0A0B1P224_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001853">
        <property type="protein sequence ID" value="KHJ32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P224"/>
    <dbReference type="HOGENOM" id="CLU_756924_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="366" mass="42859" checksum="1D82DA1ADD6BFF60" modified="2015-03-04" version="1">MSLEDRNKAVRVMSKGAALSHYYTICKENEPRPSVDTICESLKTHFEGSEHKNATLARWNAVSLYKINEVQEDKEDIEKAFWSLVTNLEDLQPMLYNELQNDIYLQDKILTSCSVHPACTMACSQPANSSSELISRLYTSIATWKSQQEHISQQQNNNYITGRVYKGGRNHFPNSNTNNSYGNSRRITNSNNKNQFNNQNPRRKRCFVCDKEECWSTNHSKNEQENTKRRYRERFNRSQNSRRQYITESEFDEENEQYLLFFEGISPEDEKQYNDHSLDYDDDYQAFLNENTSDINTPVTYHTECGNITEPEASLMLQQLLNFSTKHAITKQETIDIVDENQRIDCNQNSLSETFLIQNHYDSNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P236</accession>
    <name>A0A0B1P236_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative mitochondrial outer membrane 72k protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002190">
        <property type="protein sequence ID" value="KHJ32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P236"/>
    <dbReference type="STRING" id="52586.A0A0B1P236"/>
    <dbReference type="HOGENOM" id="CLU_017516_0_1_1"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="621" mass="69441" checksum="AC355D16B4875F87" modified="2015-03-04" version="1">MPPASNISVEHNVSKIESPSTPLPTWDRISTWASENKTVVYSIAGVAIVITGASIAYHLIDSKPFTSSHNSQKKSTKKDRRRKKDELKKGSESERSAPELKPKTVLVEPVPELLDVNEEVVAKLSEQDKIDLASKLKLAGNTAFGAKDFPKAIKLYGQAILCKPDPIFYSNRAACYNALREWEKVVEDTTAALNLNSEYVKALNRRAIAYEQLNKFSEALLDFTASCIIDGFRNELSAQSVERLLKKVAEAKVSSILATRVKRLPSPTFVTNYLQSFRARPSPLGLEATNEITEGTGKGQLQLGLREIEKKTVDGYEEAATAFRRALELGDLGDYEAFAYNMRGTFRYLSGESSEAIDDLTKSITLQPELTQSYVKRASMYLELGDKGAAVKDFENAIQQNNDDPDIFYHRAQLHFILGEFADAAKDYQRSIDLDHTFIFSHIQLGVTQYKMGSIASSMATFRRCIKNFDNVPDVYNYYGEILLDQQKFQEAIEKFDTAIEIEKKNKSCGINVLPLINKALALFQWNQDFSEAEKLCQQALSIDPMCDIAIATMAQLLLQQGKVSEALQYFERAAELARTENEILNALSYAEATRTQLAVQEKYPQLASRLQGMNLNPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2P0</accession>
    <name>A0A0B1P2P0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g1864</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2P0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2P0"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="38701" checksum="C0366F638C34C1E0" modified="2015-03-04" version="1">MIARTLRIGLIPGDGIGKEVIPAGQRILEALPSSLNLKFEFVNLKAGFENFQQTGEALPERTVQILRDECDGALFGAVSSPSSAVKGYSSPIVALRKKLDLFANIRPVKTVNTAKREIDLVIVRENTEDLYVKEERTFEATDGSKIAEAVKRISERASSRISKIAGEIALRREKARIAGEYSIHKSPLVTITHKSNVLSQTDGLFRSTSRKVLSNQKFASVRVEEQIVDSMIYKLYRQPEAYDIILAPNLYGDILSDGAAALVGSLGLVPSANVGDNFVIGEPCHGSAPDIMGKNIASPIATLRSVALMLEFLNEGAAAVLINKAVDENLIDGKFLNPDLGGVATTTDVVEDILRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W2</accession>
    <name>A0A0B1P2W2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative lim domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002686">
        <property type="protein sequence ID" value="KHJ31665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2W2"/>
    <dbReference type="HOGENOM" id="CLU_009967_0_0_1"/>
    <dbReference type="OMA" id="CGDPFTP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="595"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="690"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="753"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="817" mass="92018" checksum="5A6842000E15EA32" modified="2015-03-04" version="1">MLLRGRSRDRGSISTHPGPVYMSNDEFSEYLRNLRYNRVERPRGARPLSLNTRSEDARKEYPDSLRESLQANSISSTPNATQRPNSAFSHKRAQSSLSTTYSSVKSHTGSQTPQYNPENSQIPLLKPSDVVPSATYIERGQRWMEKEEAAALRKAMEDMNIDEESRIYAAAQKEASELVWQHQNPNLVEKSGQPYRYKNHLRKNSYQHARSESVSRYSGASQVTGLARDIPGTLRSASRCSNSSEALTTNGHILAGASDLIGNHHKDQDLKADVKNQILNKFVKDGEPRSSMRKINRNALNGSRSPITSRRNSGRRNVSGELITGPFGGDQIWEEPEQDNIERGRTQAPRELPAPLRIKDKNPINRVQFAQDSEQRTSGTLPESTKRRSIFEIHKNPPSQNRNPQYIANVLPTANSENDSSKVQKSQVPIRDGIEIRSDEIRQATSMRLKDRSPKLPVPSIVSDKPGRPIKLEDSPPIASINAKVCLIHQFKRLALPLRRSTSVLTGHRPNSKKPSPTSDISYSVPSVPTIVHSKSPPVSLTSTSLPTINIETSEPKTKRPLPVPSASSKKISNSPSNPLPQSHWSLVPGRRPTVTCHLCQLPIQNRVLKIGTDEIFHPECFCCSTCGTGLESLEIYPEPPSLRAERIDRIRRREKGEDLPEIEGKTKIDDGDERNRYYCHLDFHENFAPKCKHCKTPIIGEHIIALGEHWHYGHFFCAECGNPFEKDMTHIHIDGYAWCINCQTKRLERRAPKCKSCQKAVIGEYVRALGGEWHEQCFRCDVCEKGFDDGSFYPKQVNPSKTIVLCTHCIERELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X8</accession>
    <name>A0A0B1P2X8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003054">
        <property type="protein sequence ID" value="KHJ31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X8"/>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="OMA" id="MDTQAFC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="52"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="67824" checksum="7E73A5AEB5E11E2C" modified="2015-03-04" version="1">MATLKVTKRVQAPLITNSMRFSLQWINFKRKNSQNSSFSCLSRKFEEAGKPYYITTPIFYVNDSPHIGHLYSMVYADILKRWQVLKGKQAILCTGTDEHGMKVLRAAENASKTPKDYCDLMSGTFKMLASRANISSDHFIRTTDSSHKDAVQHFWTVLKEKNFIYESDHQGWYCVSDETFYPETAIEKRIDPFTGRDFMASKETGKEVEYVKERNYHFRLSEFKEPLLKFYKENPDFVVPSQRMKDIVAAVSSGLEDLSVSRPADRASWGIRVPHDDSQTIYVWFDALINYITSVKYPWPPGQQSIGGWPADLHVIGKDILRFHCIYWPAFVLAAGLKPPKQILSHSHWTMRKQKMSKSIGNVVNPFFAIDRFGVDAIRYYLVYDGAMLNDSDYGNQAVVTRYKKGLQGGLGNLLFRITRPIIWNPYRCVLGFAQRGSCADSFPETKDLRDTLLTLSDEVNHHFDQLEIGKALQSIMTAVFKANTYFHNTQPWMLTKYFITFKDLENRSDSLKPLEESIYNCMETLRICGILLQPFIPNKATELLDYICVDPKKRSFDFARYGADFNFGNREPTLPSQQLFPRLPVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P316</accession>
    <name>A0A0B1P316_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003284">
        <property type="protein sequence ID" value="KHJ31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P316"/>
    <dbReference type="HOGENOM" id="CLU_1171364_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="23298" checksum="C38E0C12458B821A" modified="2015-03-04" version="1">MSAVPSKPSDEATHDDNDSLNLNDELKLQGITFASSEDMKDSLKHSNRKIDIWTLTDRLNSLEKSTPIPQLKGSNWNHYYDSIKKFLYLSQTSAAFLSDPPRNRAITMWEAWWVAKLRETAPHVRTAPSDSVRTVLSEIVLTSQAQSQTKILSITARFWTFQLDKNTTLQGFIKEYQKRYQELKEHTNFSQETMNVSTQILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P354</accession>
    <name>A0A0B1P354_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002985">
        <property type="protein sequence ID" value="KHJ31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P354"/>
    <dbReference type="STRING" id="52586.A0A0B1P354"/>
    <dbReference type="HOGENOM" id="CLU_004694_0_0_1"/>
    <dbReference type="OMA" id="FVRHNAL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="432"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="725"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114158" checksum="022E989C0979C70F" modified="2015-03-04" version="1">MTHTAGVCHRNSTIGELHIRRHSLDPKDLSDVANRSKNPDYITKIPSTNETLSHVISRDKGVCSKHLILNRAPCSNSAPPTRQESIRPKRFRIMRLGHASESQLSTKARFHAQSISPPPMPQKPELVSKTSNFDTISRKLSPHKNREKKLRRRSQTTLGKLLEQSPRNHKVKKLASKITEEISSSSIIPEGTGSASFGTGQFTTQIGPPAYGDITSSTLALPLNRLSDSSRSDLSSGDHGMYASTTTTTHTVQTTTTFFRLPRRRKQAQLFNLSHLPKKSDSLEIAQSEIVSQKSESGSFNPKTEETNSSLLQTSSLVNTIDVGRIVSPPPSFAHPLKSSQLARQESRTSNKSSPTRSRLSLCDRSTLSSVQHVSTDDSVHSSTIQSTRTSSSAGRKSFGDYLGLSNKVNQNSELSCQRQSSVLVSSRTNTPKNSVGQISRELPLILPERYEDDTPAKYLIRLEEAISRGVVASVLSKGSDSFSQAVLRSYMRGFGFFGDPIDMAIRKLLMEVELPKETQQIDRCLQGFANRYHECNPGIYDSPDQAYFVAFSLLILHTDVFNKNNKHKMQKSDYLKNTRGEGIYDEILECFYDNISYTPFIHVEDDLDINGERIIQHKEKKKFIFNTNSDSSKRPSKEPIDPYTLIIDRSLDTLRLNLKDVLFLEEHYSYLGTATCLNLSDLQKTFFRTGILQIVSARSRPDAFMSDITVNNPEEAQAGIVDIKITKVGILWRKDLKKKKTRSPWQEWGAILTGAQLYFFKNTNWIKSLMSQLDTHIRQGNDGIPVIFKPPLDQFKPDALMSTDDSVALMDSLYKKHKNAFVFVRHAGFEETFLAENEEEMNDWLAKLNYAAAFRTSGVRMRGVVGGSGSYDGQRSRGIRQLEEIKESYQSAQTSTDEVSEVNEEIEAKMAQDILSARREIMLQKIADGEEKLAAAQKHLDIHLRNARHLQILAPIQQKTRENILMAAGRIAALLKWGRIRIWRLRCHIDILSLDLEEENNISLNIKSITVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Q4</accession>
    <name>A0A0B1P3Q4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative snf7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g3077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002431">
        <property type="protein sequence ID" value="KHJ31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Q4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Q4"/>
    <dbReference type="HOGENOM" id="CLU_086201_0_1_1"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="22747" checksum="95591AAD568525ED" modified="2015-03-04" version="1">MGNSSSSRKISAQDKAILDMKNQRDKLHQYQRRITVLTDREKSIAKEMLTKGEKAKALLALRRKKYQESLLAKTDAQLEQLESLTKSVEFALVQKDVIYGLQQGTKVLQAIHAEMGGLEHVDKLMGETAEAIAYQKEISNMLGDQMTNQDEDEVEDELDALEAEITGVPLPTVPSTRLPGKTRAKERLLQKQHEEQSIEMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3T5</accession>
    <name>A0A0B1P3T5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 26s proteasome non-atpase regulatory subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003021">
        <property type="protein sequence ID" value="KHJ31289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3T5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3T5"/>
    <dbReference type="HOGENOM" id="CLU_029573_2_1_1"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="423" mass="47857" checksum="3646A184FE6F03C8" modified="2015-03-04" version="1">MISEDANKREIARDVNQEKSKNAEARFQEIISQPPVVTSDAAVREYETALISLGQLYRDQEKPDQLVELITKSRDVLSSFAKAKTAKLVRQLLDLFHGIPNTIDIQIYVTKSCIAWATSERRGFLRQNLEVRLVNLYMQKSQYYDALSLINSLLKELKRLDDKLVLVEVQLLESRVYHSLDNTSKGRAALTSARTSAASVYTPPLLQAELDLQSGKLHAEEKDFNTAFSYFIEALEGYHSQDETEKATSALQYMLLCKIMLNLGDDVNQLLTSKQAVKYAGKNLDAMKAIARAHSNRSLEEYEKALGNFPRELGSDPFIRNHLRHLYDAMLEQNLTKVIEPFSRVEITHIAKMVSLDTLQVERKLSQMILDKMITGVLDQGAGCLIIFDEVERDEGYDAALATIERLSSVVDVLYTNQASQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3U6</accession>
    <name>A0A0B1P3U6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nucleoporin nup44 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003009">
        <property type="protein sequence ID" value="KHJ31304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3U6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3U6"/>
    <dbReference type="HOGENOM" id="CLU_023804_0_1_1"/>
    <dbReference type="OMA" id="SCVFKHY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="373" mass="42177" checksum="DAE20C899E29F704" modified="2015-03-04" version="1">MQQSGVFTGFGQSQQSKGPQLTSSLFGTPSQPTQNQQQGGIFGGLSSDQNNQSSQIGLNNFPSLGQSNQFQQASNSTLGQSQVQLQPLLQLGRSGIWQPNSSISPREKSVPEQMAAVFEKWDTNNPNCVFKYYFYNKVDDNMAPYYRPGPNEDPKAWDEALSNKPDKGYIPVLCVGFAQIGERIKLQQRNLANFNARLHEINNSLSRMMQDHETKFSIKVMDARRKHTVLKQRCIALATKVQVLRNRGYALGGDEEELKIKLLSLERQVNDPALGARGEEIWARMLAVQDRAKVLNSESLKAGLEVTNTMDEEFTRRSKKILEDYHTQLLHLSAELESIKRDYEEWQNDPSNPSPKTDDSSKNININRSFQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Y1</accession>
    <name>A0A0B1P3Y1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative aaa family atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002967">
        <property type="protein sequence ID" value="KHJ31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P3Y1"/>
    <dbReference type="HOGENOM" id="CLU_000536_1_2_1"/>
    <dbReference type="OMA" id="VTPKDFM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="657"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="959"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1458"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1472"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1505"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1656" mass="184924" checksum="039DB62214E19DA3" modified="2015-03-04" version="1">MPTKRKLEHFDPNKSDSNDTDFEPDEPSSKRSRKQSKKRAGNLKKRIKRAKYRGSDISEEEDSLLEESFTESSSSSEETELNPVTGRRVRKAAKKAVNYEEDTGSDSAEASDEMNTADSESNPKITKQARHTVKKTEKLDKETQVIKEEPVSKNGMRVGATRTRMVTLKIGTPKIGKTQRGLRSATLARASSLDKTQESVCVEKSRIDIQYTLKENDNSMLHSSPENKSRNSLELNLLQETQKESKSLNKPDSVTEELLETSSCNPEAEDTTMATEFAASDDFEETSKAIDLPDSKTDNVSKLEIDDPAFNDEAVDDEDLPSKPCRKSAAQSPSPEQETSNENAENKIKSRRLTRGLKSKQRKTGAEIGSDFEPPDEVSEDEPPQSDSSPKKKGKDQESESSPGPNNRRTRYSRLKNSSRRQTSSDSADNELDQDEIAEELHDLKGAPRRRRQLRREGSEVLYERTGRARNKVDYTIKSLDQIYAADDDDAENAPAYTKRTTGGRNGAYQPWERNLFSTFGPFGGGGGPAPLIGGPWGTSTIGAADSDSSDEDIAQKSIVAQGTVGTTPTSGNAPGLLPGIGQTNTIDTGANSSGNPANHGKVKSQKELADADPLGVDQNVDFSKVGGLENHINQLKEMVQMPLLYPELFLKFHVTPPRGVLFHGPPGTGKTLLARALAASVGSRGQKITFYMRKGADALSKWVGEAERQLRLLFEEARKTQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDGRGQVVVIGATNRPDNVDPALRRPGRFDREFYFPLPDLNARKSIISIHTRDWGLDDGFKDSLAQVTKGYGGADLRALCTEAALNSIQRTFPQIYMSNDKLKIDATKIKVTAKDFMLSVQKMIPSSERSTSSGAAPLPKAIEPLLRDQLKQIKFILDELIPMRKKITALQEAMYEQYEDEDHGFGREKMLQDFEKSRVFRPRLLIEGEPGMGQSYLGAAILNYFEGLHVQSFDLATLYSDPNRSPEAALVQLFSEVKRHKPSVIYLPSVETWYHTLSDAAITTFLGLLRSIPPTDPILVLGISETPPKKISHELIRDLFGLSKQNRFTIKRPSRSSRHAFFSTIGEYVKKSPKDFPDPLNRKKRKLDELELAPLPANRIPSREEIKLQKKKDHHLLNLLKVAIQPIMEQIQKKYKKFRTPVIPQSVIKYIFDEKDVGFVRSDLPGVRPYEIDKNKDGVFGLREVATGKFFYNLETSTIEERLSNGFYARPKDFLADIRSLAKDARRIGDKERTLKAQELLTNVEVDIALIEQNPTFADCENLYLRQLHRVKERKEKIRKRSGENQHDLTPELDSKQASKELNESLPVYGQDLRSNPLVKSLVNGHSMNEMSIASGDVEDVAMQGTEITETQPLTQAHLNHVLNSDSPHSMTHSSERLVLKEASHDSSFHEIVNLNTVSSKLSKKMSDSWNGRLENGIVSQISSSPVDKPTQDSDIPDTQRNTQNEGSQEWPPSHLYPLRGSLFPSQSSSLSSQTSHVSQTTPHMSNMAHLTVMPKSHPSGMANLLNESSVEPLLSSSQPQLQSQPCELSIDISYIESALNKFVDVTHSNSIEELEQICRELMNGLWQMRGEWNRNHVMNQLVNIFNDTIRDINEMQKSFSSINHCSNDLIIASNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P458</accession>
    <name>A0A0B1P458_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative urb2 npa2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002880">
        <property type="protein sequence ID" value="KHJ31444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P458"/>
    <dbReference type="HOGENOM" id="CLU_005258_0_0_1"/>
    <dbReference type="OMA" id="RRQTHEA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1450" mass="168199" checksum="610D3F7B26CC8310" modified="2015-03-04" version="1">MSSKSRFVLEELERFEQLSKSFEEQLTESAKFVGVKFTKDGKISEDKEEAKRLSKVVPFKREEWLLIWLVKKLKVEESARKMPSSWWLLNFLVRSLPKRSATRILLTKEVFVEERDNPSKQLKTSILQKTLEETLFNITPFIPPKVMDQKNTKDHSRKRKRCSEQNASDKTTDYLPDLMEAISTVLSYVVEMGSLTATDYSNDIEESFSAAYMKTTYVTSAEKAALILGLWITLCEKYYFKIEITNISIKENLLTPFIELWDCRVWDEKWPMAFSKYCSLPIFSFLNKVKHDINNYELKSQLEKLLARNIAVPAKKAYHQESCLALLESLANPVIALHILNAPTLLEIFLRSSRQQNHKHWLPEDEKWLQAVFKSLIHSVPDPQNEDFICAMLELLIDYKVDLDLELLHSLAFKLALPELAVKWRLVATLIKFDANIFLVPKDNNLLEILLDRITDAPFDLSWAAISDYMVSSILVPLMVEFARARDLLSFIKIWFNQISKFENRRKNLKHPSTARLSAWENDALHSKLRELLESSLTISQISYIIDWVSENVSKDHHAACIIFEAIVGCISGQEDIVDIISLRPYYIIFDKERYMSLNIRYRWRAWRLLNNLLNWANAENINELTNVWETKFNPLSFYLENLNSLVVAEPEEYESISEPVEVFRSVCAAYCASISGSNMEAFIGPVLLSYLQLVAKDILKYREEVRLKTNKNESRPDTMDRLLRCVFVEYPKILTLAFEFEEKFEHVLRAVFDIASESLNLSNTYDVPHFITGAYTTLWTSAIQSDVVLDNQKLKEFMIGTMLTKLTLERDSICNNHFAIMSLNQMPLDVIRRNNREDIMRAWLFPPNKEMTITETINYSCKALDPALLALKRRIMKQHPNLYEGLELESIVAMADSLSNTKISQKDVRLSLLKDLTNLIIGHAQINLDQERRKIYIIKAFKSLQNRIQNLEEKKKSHRNFEFIPIFEAALVGLNRGKKYLEKMGVIKEIEIKNITNRFREYLLARFKKTMENILIESHRESRIKKNKETCLLVIIDALTSLGVTRSQLSNLELESVPQKLAELSSKIALSINTFITIFESRNEIIDLKPLLGLDVTTYLYRKSIQQTVEGVMNKIDNLKKLQMLRSLLRGDCDNNLTPDKILAMRYIIISTEDVKSKRKPLCSDSDDSNNSSDNSVQDDFNLNLVYILLNTELRKTIDIISFCILSETLDLMLRTKPRSISQYTVDITLGTICILCSPESPHLPTKRPGTIFLHLSKLLRSILNYHRLKLNGHFPLVQLSMQGLLRCLFQFRPKKFCRNITDTSTSNPTIAEFDSMPIWLTNTNYQLNARNAESYTRLLTLISDPSESSVQGSKYRISNHLTSAADKWKRRAVLFMRFVLMSYIRWTLKFPMLPEIKEQLMPGWFALLDNTTTDTRRLINAELLNSSNRAIFTNLYREYQKFGKWNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4G3</accession>
    <name>A0A0B1P4G3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002771">
        <property type="protein sequence ID" value="KHJ31569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4G3"/>
    <dbReference type="STRING" id="52586.A0A0B1P4G3"/>
    <dbReference type="HOGENOM" id="CLU_005319_0_0_1"/>
    <dbReference type="OMA" id="SYEDSGR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121489" checksum="9A3B20BD3FDD9D9A" modified="2015-03-04" version="1">MPFPSEKDSNFISGRRIKFNNISQKLSSTDLQSFEGQSRKDDTTEIRHGDDIMGNMTRLNFQNTETHKQFTGTFLPKLDTVLNLKRLPTTLNLELLSPAAIGFSPPSTDTSGDTSRWADSISTQGFSSNNLISLGESPPNLGDESGESELGWKTKGQRKSLLEHLPTLSPTISRREILSSQFNVSESSDTHNSQALLFDFDRGPTLIQSRKSQNTPLPHQLQPLFPGVPKVDFMQTPQASGVDLNESEFYCGFDVLWKEKVVIIGFETGLDIFEVTKKGISRTSRLNGLRGGVFNAKIIPWTANFRNSGPFPLIALVIHGPAKNISGASNVGVVSENVMSNHNGIMQDTTRRVYTSTDTEYYQTSVELYSLSGSKKHIGTLLSLPKIPLVTDKNSDYGVSSPVGSLTILADCGNLIVTSGITGETWIFKQFNCEEISNQQFKCIGKVWTSVQQVTTTEGLSEKINDLQDLGSLSRRKKSSTSILSLKSRWLAFCPPTPSSQTCLCGVVTNMNPAVKIPGLATKTAPNLPEVNCGTKTPGAESMVKQIAQVGTQNFIRAGTYIAQQGFQAWTNYRSKPATTTHKKSTTQINPSMPSSFTSKDPGLVSVLDLEIFTQSDTFLNSSSVHPNFTFRVPYGCSFLSFSPHGLSLFTASSKGDIQFVWDLMQICYPKNSLQISDQIATGTQGPHIRQIAQFSRMTIARIVDVVWAIPNGERAAMVTEPGTIHILDLPTNAFKWPPLSNKTLEAEDLVDQTNNSSLRASSVATSAVNSLWTAAIPLVSNRRRSSTCLSTRSISMTASHSTQKLAAGISRSVGAATEKMNEIRKSIGIKLHLPRSLAAPNRNCIIFQNKKGNDIIFTLAGSMIRIYTVRKRRTDESTDKQKTPVKEFVEYKIPRFSKPKFSSDLNQEMRSNRKLEFVETEIDEKGQKSRQASLSHRFIPSIESSIPYAEIESNAPYRPFHTDRFVRLYTYNDQAERLPFLNLNIPINDETVISHTKSPQKMQAWVFGNTINAIKIDLGKKSHLENKFKNSNTSRTLSSAATESIIRVLDSTSNVENLIITTKLCKSSPQSDIKGIANEDGFFEDDCELLDFAKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4H2</accession>
    <name>A0A0B1P4H2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="20">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">EV44_g4622</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="20"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001339">
        <property type="protein sequence ID" value="KHJ33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4H2"/>
    <dbReference type="HOGENOM" id="CLU_000513_2_1_1"/>
    <dbReference type="OMA" id="WSPFNGK"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
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    </evidence>
    <evidence type="ECO:0000259" key="29">
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KHJ33602.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2185" mass="242358" checksum="FACB1753468A700B" modified="2015-03-04" version="1">MPLISHFPGTAKIATIEENELICLELQDGTLYHGHSFGARKSIAGELVFQTGMVGYPESLTDPSYRGQILVLTYPLVGNYGVPSREIMDTMLEDLPAHFESSQIHVAGLVIASYSGEDYSHFLAISSLGSWLKEQGVPAICGIDTRALTKRLREKGSMLGRLLSSIELETIQSNSKKHEFSGNDHSELFQLTNWLNPNEINLVAEVSIQKPKLYTSSSIKKYKHPSGRNICILCVDVGLKYSQLRCLLRRGVDVLICPWDFDFIPLLGKECDGLFISNGPGDPAMLEMTSKNIARAIDINRTPIFGICLGHQLLARAAGASTIKMKYGNRGQNIPCTNLLTGKCYITSQNHGFAVDSSTLTSEWTELFVNANDGSNEGIFHLHKPYFSVQFHPESAPGPKDTEFLFDIFLDIVNRVCVDEKLLKTPIYFRSEENTNIKNFYSELNVKKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIFTILINPNIATIQTSKGLADKVYFLPVSAEFVRKVIIREHPDAIYVTFGGQTALQVGIQMKDEFEKLGVKVLGTSIQTIITTEDRELFARSMESIGEKCAKSASATTIEEAIHVVREIGFPVIIRAAYALGGLGSGFANNESELLTLCSKAFAASPQVLIERSMKGWKEIEYEVVRDVHDVCITVCNMENFDPLGIHTGDSIVVAPSQTLSNEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSKEYCIIEVNARLSRSSALASKATGYPLAFVAAKLGLGIPLHKISNSLTKVTCACFEPSLDYVVVKMPRWDLKKFTRVSTQLGSSMKSIGEVMSIGRTFEEAIQKAIRAIDFHNLGFNDTPALMSIDDELQTPSDQRLFAIANAMHSGYSVDKIWEMTKIDKWFLTRLKGLSDFGKLLSNYCTESVPIKLLRQAKQLGFCDKQLAKFFTSTDIAIRRLRIEAGIVPFVKQIDTVAAEFPAFTNYLYLTYNGSESDVTFDDHGIMVLGSGVYRIGSSVEFDWCSVRAVRTLRDCGYKTIMVNYNPETVSTDYDEADRLYFENINVEIILDIYHLENASGVLGAMGGQTPNNIALGLHRLNVRILGTSPEMIDTAENRYKFSRMLDIIGVDQPKWKELTSLNDAKFFCKKVQYPVLVRPSYVLSGAAMNTVYSETDLEVYLKQAADVSRDHPVVITKYIENAKEIEMDAIAKDGKLVGHFVSEHVENAGVHSGDATLILPPQDLERTTIQRIEEATRKIADALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDLIEMATKAIMNAPLVAYPPIQLPSGIIGVKVPQFSFSRLSGADPVLGVEMASTGEVACFGVDKYEAYIKALISTGFKLPKRNILLSIGSYKDKKEMLPSILKLQNLGYKLFATAGTADFLQENNVNVHYLEILGIDNDEQKSEFSLTQHLINNMIDLYINLPSNNRYRRPSNYISKGYQTRRMAVDYQTPLVTNVKNAKLLIEAISRKYSLEISNIDAQTSYKTVLLPGLINIAAFIPGIATPGSNDFYDVTRAFISSGFSMIRIMPLGLDGSMTNAPTLEIARSNTKDGAFCDYNFSVAATSENSEHLGQLKKEVASLFIPFNHFSDNISKVATVTNHFDSWPNFKPIVTDAKMTDLASILLLASLHGRKIHVTNVTNKDDIKLIALSKKKGLDVTCDVAVYSLFLSQRDYPTAEFLPTFEDKEALWENLNVIDVFSVGSVPYQLAQRNSQPPDPAIGVIDTIPILISAVVDGKLTIEDIKARLYDNPKKIFEIHDQVGTSVEIVIGRPCNSISSSVWSPFPKNGMRGAVQRVIFNEKTVCLDGKLCNEVIHGKDMSPHLVEKHLIETSIVNNSLLLEVKETSSSNFGNKSPFKDQHILSVDSFNRQNLHSLFTIAQDMRLGVQREGVLSTLKGRVLCTLFYEPSTRTSASFDAAMQRLGGRTVAVSTSNSSTSKGESLADTIRTMGCYCDAIVLRHPDESSAVIAAKFSTVPIINGGNGTYEHPTQALLDLFTIREELGTVTGLTITFTGDLKHGRTVHSLVKLLQHYDVKIQLVSPKALALPSEVIKLIRLKPNQLLVESTELTPEIISCSDVLYCTRIQKERFKDISEYKKSENSFILNNRTLKDAKSTMIVMHPLPRNQEIQEELDFDQRAAYFRQMRYGLYIRMALLALVMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4K7</accession>
    <name>A0A0B1P4K7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4K7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4K7"/>
    <dbReference type="HOGENOM" id="CLU_035750_0_1_1"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="31527" checksum="2A97211CC883D3FB" modified="2015-03-04" version="1">MTSIGTGYDLTNSVFSPDGRNFQVEYAVKAVENGGTSIGIKCKDGVVLAVEKIITSKLLKPGANNRIATVDRHIGTVSSGLIPDGRHFEQRAREEASSWRQIYKSPISTADLANRMGQYLQLYTLYSSVRPFGITAIIAGWDSESEIPVDSEVGSGPEIGSGGKAEGKTYGGPGLFMIEPSGSYWGYYGAATGKGRQTAKAELEKLDLASGTLSLLDGVNEAAKIIYLAHADNKDKEFELEMTWISSLNGPTKGRHEHVPKDILDEAERLAKGALDGEDDDDDSKSEDVKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4M2</accession>
    <name>A0A0B1P4M2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4M2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4M2"/>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000058">
        <property type="entry name" value="Ribose 5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="324" mass="34619" checksum="8E0704545CFA3F60" modified="2015-03-04" version="1">MAVSTPTPKVPVTCNVEESKRRAAFRAVDDHFDENFTYIGIGSGSTIVYVVEAIAAKGRNVTNRMIFVPTGHQSKQLIIEAGLPLGSIDSLPPVKAQETEIKPGEVINVATGVTDLGLKGKRESLDVAFDGADEIDEELNCIKGGGACLFQEKLVATSAKKFICVADYRKLQPRLLSAWQSIPIEIAPTSAPTIKRILITLGSSDPKIRQGGSAKAGPVVTDNGMWIVDAPFPPLALKKDLKGSDPGDGSLGTWEVDNLGRRLKRIVGVLEVGLFYGRNGIQVANAGEEGGAQKPVAAYFGMEDGTVEVRVCKEFEAAEKSRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U8</accession>
    <name>A0A0B1P4U8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002160">
        <property type="protein sequence ID" value="KHJ32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4U8"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="OMA" id="RETFDCH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="363" mass="41270" checksum="B080A59D699B81DC" modified="2015-03-04" version="1">MTCLYKKIRRATEDNLFNRANVVSITLIAIFITVAFMIMAEGSSGSRTEHLELSTVAGYFQQDDPGTDAASFDFTKNNFGLIKRSYENDALFDPDLKMTQWQRFEAEVFHLNSRSGPNTKYKVLYMGRHGEGYHNIAESFYGTKAWDCYWSRQNGNETMSWLDAELSPLGVSQAQSAHKFWAEMIEVEKIPIPEVYYVSPLLRCQQTAWNTFSGLNLPIDKPFKPVIKELLRECIGAHKCDMRSPKSKIQARYPDWVFENGFSETDKLWSSILRETDEAIDQRTKIVLDDILLNDKHTFISISSHSGQIGSALRVLGHREFKLSTGQAIPVLVKINKISGPSPPVNKAPWFIPEICERPPGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A0</accession>
    <name>A0A0B1P5A0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001192">
        <property type="protein sequence ID" value="KHJ33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5A0"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_2_1"/>
    <dbReference type="OMA" id="THYMEMI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="36685" checksum="16006E70F3D0C964" modified="2015-03-04" version="1">MNPNRVSITICGDGATGKSSIALRLVRSAWTSIYDPTIEDTYSVTRQIDRKPYHISIIDTAGQEKYRSLWKKSNYCSDAFLLVYDITRPESLSVLKEFSKLIDQKYDIKHKVLKHNVLKHPIDTRGKNNSFEFKSRHRSIMSGSNEQYKTHQKPIKVLIGNMCDLQQKRRVSIKTGIKWARKHGCSFLETSAKDMINIEEVFEMTIQQVLDSRKNAVMGKNAQNYIRKSLTDNHQLALHFKTRDQFESISYSETTLLNSPFLGYNEYSEKDGNTFDFKKHRHGRARIKEIIRYNWRDFGWDSCIRRMRPIHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F8</accession>
    <name>A0A0B1P5F8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ras-like gtp-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5F8"/>
    <dbReference type="HOGENOM" id="CLU_041217_8_0_1"/>
    <dbReference type="OMA" id="HRYVKNA"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="320" mass="34884" checksum="5D3B1CCE9B537ED2" modified="2015-03-04" version="1">MAQSLEAKIVVLGSQGVGKTSLVHRYVRNQFQPANISSTVGASFLTKKVLDDESDTVVRLQIWDTAGQERFRSISRLYYRGANACILCYSIMDLNSFTEMGVWLLELRRNLPPDIILHVVGTKSDLVSRDPSLRRVPFERCIAFVAENMAPGVSGTPPVSAGAGERYGESRGGIFERAFSGAPLGISGAGVDGARSPSSKRSSGFWGQEVGWDCCHEVSAESGEGVEEVFRVITRKLVEQNRLIQENILSAVQSPGMEESESGESGYFSERNTSGRASGSFRVGRDRRSWFGMPVDDVMEEAHSSARGGEAIARKGKRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L4</accession>
    <name>A0A0B1P5L4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amp-dependent synthetase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002453">
        <property type="protein sequence ID" value="KHJ31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L4"/>
    <dbReference type="HOGENOM" id="CLU_022749_0_0_1"/>
    <dbReference type="OMA" id="ADWNIYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="61902" checksum="1624809ABE20DA39" modified="2015-03-04" version="1">MDYILTELDRLVTRTLSEWDHISTALFILSISSVIYFTIYTRAPDIHPLFLERQSQASPIRQKGESAIFRSYSTPHGTELSTGLNIRSLGESKWAHGKDGDLRDIWKKAISGSQDTTGKNAGKIAKLLTLQGTSDLIEHDLDEITRQINIIGRYLKNHQSKRVAIYLPNSVEFIASLFACAFFELTAILLQYDQYPTVLLSQLEKSKADTVIAASGSFPFEIILKGNLALKHLVFVVDEGSKHIDWKEDPVGLSDNFEISTWHEIVRLPLSSSEASLPYDNSVELKRIVVFTAEEMVEFTQANIIAGIAGQLASIPATQIFTPSDLFLPINCLSEIHPLTLTLSALFSNADIALTAVASHSPSLTIAARGIAPTIIAASSASMIKFHDEIKQEISTPLFKFIHRLETRCLTRKGYMPTTSFLSSFFSNIYPKIGNTPGKLRLIYISSLAGVDKPISSSMLSDLRIFTKSRIIYALTAPRVAGAVSQTGIFDYRVCKKPEMAHFGAPVTSLELYFQDRGEYKTTDITSCGEIVATGPAVEGGKAKLGVVGKMNHDSTLSLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5M1</accession>
    <name>A0A0B1P5M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ph domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001355">
        <property type="protein sequence ID" value="KHJ33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5M1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5M1"/>
    <dbReference type="HOGENOM" id="CLU_005248_1_1_1"/>
    <dbReference type="OMA" id="WKESQWR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="111"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1276" mass="141371" checksum="17FDF20C5225D72B" modified="2015-03-04" version="1">MGNRSRVLSFISNFSSSGKDGRNTPTPASQSQPNSESQKVGSSSINQSAPDLSTSELRNSQQNLAQEHISSSSKPMSMLFQTYKPPILDTDQNTLPELQPIFTLLNDHANKLYQEGYFLKLDDQNTQGKPNPDRIWTECFAQLVGTVLSLWDAAELDIVGQDGEVLPKFINLSDASIKMIESLSTRSQTDAPLQNVLSISTAGKNRYLLHFNSHHSLIQWTAGIRLAMYEHATLQEAYTGALIAGKGKSLNNINAIMDRSRSPTADWARVRFGAGTPWRRCWCVISPADEKEVIKWQKQWKKSPYDRSRPPTLKGVIKFYHSKKTKKTQPIATISDAYSAFAIYPQSKPLIDASTLVKVEGSIIIHSTPPSTTEGFVFVMPETHPAVTGFEMMLRWLFPVFDTFGLYGRPGRLVAATEDVRSLMFAMPTQRRHGYLEIIDVVGLILEEGSLNWKESQWRKRMKELTAKRMIAIESDSRADSRLGSRRGARNSMGPSNLRNVKFDAEGDKASVKSTPSTSRALKSGADGKINGSRIRTDSAPSLSTLKLQSQPGEIHNRSESELDSNSKNMSQLQEIRCLSTCGNTDQKVLLSSNYLESSIPKQREELDATYERVSSEDEQSSEATQVSELQELKLNTSPEPVAAPPAFVHGPGSLPLSKPYHSPELRRANSRISSTTLNQLTSAHITQVDSLNREERFTEKDMAFREGEKNLDSTKENNSVNESARNLNVKMKKLSFEKLSSFNLVNSNDQTLIPQNKASRSSSSLMIDKISYSHPPPNKNLPLNPTEKLDSNSKVEPDKDSTSILLEKTAQKSLSDVIPALDVSISESEKARLDSASPNGYFINQDIFDKISSDSARFCAEALRDNMKYNHKATKSSDNLRNLDKPRAGVMRTVGDPQLQSTEMLMEKLNFDINFGPTFNYASSKNSGLLNGFLGSNNSKKIPSENNLHNDYSAGVINVKGNSELRDSITDDLEKPNTENRKLAWNPTLAGCVSSTTQQKSITPEDFVAQRNNIATMYVHRRFPSLDALRTVTKTPPLNGSRPKEIFNFSSHSRTCSSDFSVLSNHSRNYSNELLQRPSSISAVRALGPSGISRKFSNDQFSRPNHTQNASIDLTLRPRSRAASIILNSAGNGSNMVTSQLTAREQEHLAKVTGQPLISMATNGKNIPSAGLVAALEAREKDKSIVKQGLNSRAVEHVIQQRQQTQSQKHAYSASMDFQSQLQSPSILVKSGKIWAVTDPTKSTNLEHGRSMSSFSPSECYSPSGFRGRESIKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R5</accession>
    <name>A0A0B1P5R5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R5"/>
    <dbReference type="STRING" id="52586.A0A0B1P5R5"/>
    <dbReference type="HOGENOM" id="CLU_033658_0_0_1"/>
    <dbReference type="OMA" id="DYTPHFL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="11" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="34718" checksum="956316308B081D9B" modified="2015-03-04" version="1">MNILQPIHPSSFSEFPLRHHDAHQHHSALSHISSQKMSSINRARKRKAADDDADSGMSISPTNSPPAFAPRSLFRPQKKIKASNISGHSLSTHRLFETLDASSLRTVLQTICERHPDISSEVISLAPRPSVEAAIEVLSGYQERLQAAFPYGGNPGSDYAFNRVKQHLTNLIDAVTEFTPHYLPPSEDQTTISLSFLDFATKVIHDLPEWESNSNQHYKENAYDEITRAWVLVVSEASKRGGGFQIHAGGWDQILTKHNEQSRGRMESAVRALGSHLGWIGGMAIGSEYGSFCNQILNCTPRSAPTPIVVRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S1</accession>
    <name>A0A0B1P5S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative enoyl-hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g6480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001330">
        <property type="protein sequence ID" value="KHJ33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5S1"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="DPDLHWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="275" mass="29602" checksum="BE50D0C1A66268BE" modified="2015-03-04" version="1">MASKYQTAPPSSPHFRISSLAPSILLVMIDRPKSLNALRITDHFALDSIFNWFDTEPSLNVAIITGNGPAFCAGADLKEWKQNIESGGSVIDTSPRTGFGGLSRRVGKKPIIAAVNGICYGGGFEMVINADLVIADEAAQFALPEVKIGVAAIAGALPRLVRTVGRQRAMEICLTGRTLSAAEIREWGIVNTVVKNGECVAEALRMAQLICQNSPDSVICSKEGINLGWENVSAEEGTKSLIRGTFMRMNNGKNMAEGVKSFLEKRNPVWIPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P635</accession>
    <name>A0A0B1P635_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001823">
        <property type="protein sequence ID" value="KHJ32775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P635"/>
    <dbReference type="HOGENOM" id="CLU_039754_0_0_1"/>
    <dbReference type="OMA" id="EYWEHFA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="281"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="47561" checksum="77072B9E20F78C57" modified="2015-03-04" version="1">MILPPEEIKIKRKRTDEPVDILHIQEPLGKKQRCWTDFIFCRQLSHSAATVASATSQNIPNNHAPTLPLPSSSIDQKIKKVEKNDNVTIPRHFHIYHPKVIQTPNSELPSRKRKADTIFVERRVNSIRKPRLEENTLSSSVSSLNPKSNQCMIKNSKLPSDRNHKSPCKVPSPAPLRNVRLPSGDIIPWDVTSQELIAEMQAYTLSEINKKIVESEKERNSDTLAPDASSTTTITERKQDARFKPKAPTLRYKDRHLNKPELETDNGNEIESCESIEDESEDWVVEKYFRVPLEDTQFENHDNHGYLVLDSQAEIEEFFQDDSNSVEENEEDEDENAENHYTADYPDEEIELDDEFDFNAYNYTNDIDEFEIDTISDDEIDEKRKYPWAQKPWIGRQDKLNYDEDTDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P638</accession>
    <name>A0A0B1P638_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002113">
        <property type="protein sequence ID" value="KHJ32391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P638"/>
    <dbReference type="STRING" id="52586.A0A0B1P638"/>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="OMA" id="YYFIESL"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="8">
        <location>
            <begin position="191"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="296" mass="31339" checksum="C9A1CBB7C51622AE" modified="2015-03-04" version="1">MTGGTLLIIGCGNLGTAILSGILSSIFRSTQPNSDSNYENSKLKRFIAYVRQPESAERIKKVLGPVLSQHVEIEQHQDNRDILPGIVKKADYIILGCKPNSVRSILEIDGMNEATRDKVLMSICAGVTTNQIANYLSCPRCSIVRVMPNIAASVKQSMTVISSDHPLPFDVSTVISWIFSNIGQVAYLSDSQMDTATALSGSGPGFFALLLESAIEGALAMGMPRDVATRIAAQSMKGTAELILAGEHPAILKDKVSSPGGCTVGGLAILEEGAVRSHVAKAIREASKIAGKLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M1</accession>
    <name>A0A0B1P6M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative zinc finger c2h2 lyar-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000943">
        <property type="protein sequence ID" value="KHJ34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6M1"/>
    <dbReference type="HOGENOM" id="CLU_024874_1_0_1"/>
    <dbReference type="OMA" id="CMVHFYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="44693" checksum="14EC34BBE2F433E3" modified="2015-03-04" version="1">MVSFSCEACGDVLLKKKLDAHRRQCVNASYTCLDCMTNFENNDYRAHTSCISEQQKYEGALYRPGKNKSERSNDSIKISTIPNSKKTMHIGSTSKSASAMNVFDFLDIDQTSLLSDPEHLKGGLKYLDKGQTKSPHIFREISGNKAKINDHQASAVIKSPKLDQKIEQYRDKTDCGDILNGTKRKRLHLEPRSPALCDQNKIKENANAVILHTQLTGDLTRLMRHPSSFPLSPEFPGENSHGPAKISPTPSAQPTKTKGTKKRKETFSIGSGVKAFITAKPLPTKLPERHPSKSTKPQPLLLEDHPKMKRRTIKEATSEKDNESLVVYQPRSKQAQLLFGLIDKGLESPRGVSMSKALKKFHRERELLGLGAGKVTNEKELLKNLRVRRNERGELVLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6T3</accession>
    <name>A0A0B1P6T3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001128">
        <property type="protein sequence ID" value="KHJ33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6T3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6T3"/>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="311"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="522"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="705"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="821" mass="91447" checksum="0CF503A3EB1CEB63" modified="2015-03-04" version="1">MLSKPMILFIDAYDSFSNNIISLLETTLNVSVRTVKIDNPVLLASKNALHTELRNYVAVICGPGPGSPENKGDVGLIKQIWNLNNEEMLPVLGICLGFQSLCLEFGASIQRLKGPQHGIVRKITHNGSLNDTKSIFNEVGEIYATLYQSLCVDIGHSSMSRGEQEKKKWQPTDQCPNLVPLAWVESDISKSNNSGIKDEKILVGIQHANYPFWAIQYHPESICTNNESKKLIKNWFALVTDWNQSSGRKCVISESPLQGLSSIHRPLSSQNFQLKSVPHCSGYQITCNNAVSEIRCFTRKIKLTFGMTIPDIVERVQDINAEHILLESSNASQSSSVKGRFSIIGLDIGSCTRIEYQVGQNFFKIVKSQVDSDNSTIRISSEQSCEEVWNYIATQLEMVKDCSGNIESIFWGGFMGYTTYELGLERIGIKPDFKHINNRSRPDLCLVWVNSSIVIDHANNQIFIQKLAPQADGNSVYHWIDKIVQELEPKLVLSKSASPTNLKHRKKSFAKSRFKLILPPDESDYQNKVLACQSHIQAGESYELCLTDQTIIQIQQPKSAWDVYKMLRLSQPAPFASYLRLGPVTFISASPEQFLKWNEIGDCELRPMKGTVKKSSTITSTTEAASVLHKPKEIAENLMIVDLARHDLHGICGSGNVTVPKLMVIEEYASVFQMISVISGKINSPFKGNNLSLPEKKTVEGSEIRGSHTGLDVLVSSLPPGSMTGAPKKRSCEILKEIEGKERSLYSGVVGYLDVRGRGDWSVNIRCLFKWDDESIVTKSGETAWKFYIGAGGAVTSLSTAFEEKEEMLAKLEGILKIFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P716</accession>
    <name>A0A0B1P716_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative c2h2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001865">
        <property type="protein sequence ID" value="KHJ32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P716"/>
    <dbReference type="STRING" id="52586.A0A0B1P716"/>
    <dbReference type="HOGENOM" id="CLU_622863_0_0_1"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="49484" checksum="E8310073D65432E9" modified="2015-03-04" version="1">MVDASVGQQSFFKMESSPTPHLLSLERSDIKLCQEEVSPSRISEDIDMQGMIPHNLTTQVTDKVPEKSKSDSNKKKKKGKVQIFYCSDFPPCNLSFTRSEHLARHIRKHTGERPFQCHCNRRFSRLDNLRQHAQSIHQNEEIPEDSLALISSRSQRQIRNEKGKVVGNRTKSNSAGSQTGPIRDHKRNSWSLSSISSVGSVYSASYVGERSLPNSHVMPVSDKMGFGRDTPGFLDSELPPIKNQPLSPIRLSISPVSDSMLASSESLSWKSSPDSPFSGHINPRPFHTPNRRLSFSLPFDNSLLSSPCKKNEPTAVTNLEGFSLPPTHTMTLPTLATSSLKQEFKETNILNEEPNRRRTWHPDLRTSLSLNTQQSNLPPLITRDLQTQPTIPQHNAPTSLNILRLPGIESFGPLYRPKTPPPHIFSYLKRDSMRISENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P733</accession>
    <name>A0A0B1P733_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P733"/>
    <dbReference type="STRING" id="52586.A0A0B1P733"/>
    <dbReference type="HOGENOM" id="CLU_018502_1_0_1"/>
    <dbReference type="OMA" id="WDSMRAP"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="510" mass="56012" checksum="D3F7EA7306955CA0" modified="2015-03-04" version="1">MGSPPAVIIVIRHGARLDAADPQWHLTSPTPYDPPLTYGGWCQSKVLGARIASILHNRENDEENINVIPGALEKRGRRKRQHKIVIHTSPFLRCVQTSIGISAGLAQNLITQTPPSKHGITSHKIRPMHSSPLIRPTVMESSVLLSIPEPAVALEKENLLEHHKKIRRCTVRVDAFLGEWLTPDYFDMITPPPCSMNMITAAKADLLRREDYSNLKNFMDPKAYQPFPGGWGNTETSPNSGSESNKGNNKNSLSSMSSLDAALPSRERVINRERTSSLVISGSHGSRHKGTAIQVEPPRAQGTNGFYQPPVPCYAISKSDPIPPGFVSHARDACVEVDYQWDSMREPQAWGMGGEYGEEWSSMHKRFRAGLQKLVAWYQKSDGLSKSINRNRSNSLRIFSPEEEAVNKNTDLVVVLVTHGAGCNALIGALTNQPVLLDVGMASLTMAVLKPTPVPTIKESSLESYDSSSVSSDKKISLSDLYDVKLIANSEHLRSSTNSTHSSSRTAMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7E8</accession>
    <name>A0A0B1P7E8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001789">
        <property type="protein sequence ID" value="KHJ32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P7E8"/>
    <dbReference type="HOGENOM" id="CLU_000511_1_0_1"/>
    <dbReference type="OMA" id="QERWTCI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="120"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="843"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1567"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1664"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1810"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1567"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1681"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1818"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1829"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1898"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1913"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1995"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2006"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2029"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2064"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2078"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2160"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2198"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2211"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2221"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2314"/>
            <end position="2348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2354" mass="264888" checksum="C0CCA0095A9CB1D3" modified="2015-03-04" version="1">MAPAKRKRGDRQSMDSMDNRASPYRPQNNNLSQYEMRDGPRRPSRGGQGGLLGRAGRRNDFRDNPNQLIVKGRATSTPGPMSPSQRPSSASQTPSQTPAQADNVIFLPRSDTLPFEYSFVTEERLSKWGYSGRDTLLALGIQARRDEDTMDLGSIFQELIKSTLEGRIDPESAGNCVQEILGVETTRDPASLFNPQTFFLDILSMVCEAEEGKRGTALRVFIITTGIPPAVMRQKLDGKLLQELGLTRETFVRVGVRQATNLLYRQANYNLLREETEGYAKLVAELFTTSESERPSSEAVDDAFERVKALIGTFDLDVGRVLDITLDVFASTLIKHYRFFIKLLRVSSWWPRNIDADSPSYYEHRGLPNWALPTSTSFLPLEEDERILKTYKQERDIAFWAKARQIGLDAYFELSGAQGVEKEKIEQLLREKNNGKTLDPDQEWMVVTGTLPPSGNYVAAQLLGFKLRFYTSNTRDEEDVLPPNLMYLTALLIKIGFISLRDLYPHLWPPDEAMPAVREARRKELEEKERLNRPGGGMNALMMAGALPDDTLPLRGREVSNPKVDTTNPISEVEDKEKSEEPTDQKVLLLVCLLTIGAIPEALYILGRFPWLPEAYPELIELINRILNYSIKDIYQANSPISHIKSECPARMVPDFDQSGLPKGQLRLSPLPARKQLRWPFPDKFDTNENLSYRFYWDEWTDNIPLCQTIDDVFTLCNTFLNLSGVNIGKDAALLSKLARIGTMSLATDKSQHNYERWQSLLKRLLVPALSLTRANTSLGNEIYEMLRFYPLSVRFSIYAEWFEGQTSRTPAMKIAFTRAKLETQSIMKRISLTNLTQMAKSLAKTGYASPGIVFSIALGQIEAYTNLTEVVVECAKYFTDLGYDVLVWSLLNSLGGKNRNRTNSEYALLPSRWLLALSSFAGKVYRRYGVMNLSPIIQYINDQLYKGNATDLVILKELISQMAGIVPDTDYNDSQLVAMTGGEALRRQTLISLQDKRFESVKTAKRLMRALSDTNLAGELLVAIAQHRQSAIYKISDEEAHIKLLATMIDDTQSIMFQYLDLLRYNLSVEDFDKQVPNIPRLLTEFGIQPALAFMIGRGSIAYRLSRIPFIKGSSNQENSGFSKEATPNPIYSEGNVELINKETQSSNSKISNEDVAMEDVKIDGVQEALAATSPSPEEVVLPSDMIQEILEPVMTSVKTILPEESFRGVTPEFYVKFWLSTLSDFSIPSSSYENKVQELLNQVVEIGKDRSDMTRQGMAKKEENKKTLNIAREAVLKEFAKAIYSYPHKKARFLEQKSQWFNSSVKADEMSDFLLEKCIFPRLLLSPSDADYCFRLIKLLHDNGVPHFRTLSLYGRIFRANRLRSLIFSCTIREAEQLGRFLRLVLTDLARWHSDSTIYEKEAWGPNKNYPGFAKSLDADGKPKALLEHDGTPGFKHVCFGWQKALNTALRDCLDGVEWMHIRNAVTVLKAVVEVFPAVDFMGNSFIKQLEAIAKRELRVREDLSLTSNATLVQLKKQSKRWVIVQAYGSNLVGSTQANSNASKSSTVTNIKSIINPNASEFTSKSRASSLTLTTPKTASEVEDGEVDDTRITVPVQSVAPNLPTVEFKPNETAVPVTMETKKSEILDRREQIKRENAAKSSSQPSPSNPLQPELARTVNIERTGHILPNRPDAPFPSRDIRDRHQSRHGDRRDTRDVRNQDQRSAERLPRPGDRSREFSSERRNIDPNNREFGRPDRERTRQEHPTRWTENLRENNDRSSNSRAEVGRLSRDMPPPRNLTASLDRASINVPERIVINSDRQELINPERAALISGENDNSRSNSPRRGREDIEKTSPRPRSPKRSASDSNYDQRWNDRSSRAPLSDTYNNPPRGRKEEPIPPPAGPRDRSSNTDRSSFSLSTNLSNINSTDQGRSNVNSRQQLDPNFGRLNAAPPSPEIPSGPRDLWNPRGNRNNTLARHDGRVTVENSPTQNPDRPPPTGPSGRHARRDGSNNHSDASISTAVPLPTSPSTLSPVPGIHPDRLKSLGNSMIQHTTSPTLPLTPIHQSPSIHPDRLRALGESSQSSTNHSRSQASFSQNLGPPSGPKGSQVTNLTTPSGSGSNYLSTPTGPASTSERVSRGTRRQLAGINTMLQSNSDRPIVRGRGRITSGIGGSDSPFSSNSLNNQMATGSQLSRGETISDSDHVDLITGTSISTDERERERSGRRERSGRHSRRSSRSTERDRDSKRGIPDEDRGYRDRSDRRFNERDSERDTRHAARQFGEDLIHTGRDRDRERIGRRDGRERDPTRDQQQTSSGLDRSRGTDNSRSGRSRDVKGGEERRDSRGVRGEDGRKRHGEEGIIDPRKRVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7N8</accession>
    <name>A0A0B1P7N8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000741">
        <property type="protein sequence ID" value="KHJ34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7N8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7N8"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OMA" id="MTLIMEG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="61"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="541" mass="60925" checksum="CC74F790AE67DA2D" modified="2015-03-04" version="1">MSIIDKSILETTAKHEEDIGRAPSLEKSQYYTTQGAHRAEELEKNMTVNEALKLWWPAAVYSVAISTGIIMEGYDNLLLAQFYAMPSFCKKYGSMGPNGKYEIPAKWQAGLSNGCLAGEIIGLHLNAYAIERFGYRKTLIYSLGAIICFINILFFSKNIVMLLIGEILCGIPFGVFQTLTCAYASDVCPVKLRPFLTTYTNLCWVIGQLIGSGVLRCLVERTDQWSYRIPFALQWFWPIPIALAIFFSPESPWWLVRHGRNEEARKSLAKLTDPKGAPPEFNIDDTLDMIILTNNIEKAQTQGAGYRDCFKHTNARRTEISCITWVIQNLCGSAFMGYSTYFYVQAGLPTVMAFTMTLIQYGIGFIGTVSSWYLMGQFGRRTLFGCGLFFLFIILLGIGVAGIIDNKVTGWVIGSLLVLYTLIYDCTVGPITYSLVSEIPSTRLKNKTVVLARNLFNLAGIINYVIVPFMLNPTAWNWSGKSGFFWAGVCSLCLTWTYFRLPEPRNRSYADLDDLFERKIPARLFSSTIVTPKEQKNDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y5</accession>
    <name>A0A0B1P7Y5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative glycosyltransferase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001412">
        <property type="protein sequence ID" value="KHJ33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y5"/>
    <dbReference type="HOGENOM" id="CLU_024640_2_0_1"/>
    <dbReference type="OMA" id="DMPGRYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="213"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="56882" checksum="059B7100697CF027" modified="2015-03-04" version="1">MLPRTTPLLRWSVIVFFGIIVYFYYSDLSMTLLLRNKDQLADLDDLEYVKLLLKKNKVKSEIEFASRTIRYIPDAAERKSVTNVYENLFPQLFTKISLAKVSTFPPSRLLDLHVKQSPRPDEVDGTSLLFGLSTTFERFHDAITSPVKEWSRWLTDGNGRSNGAGLILALLNSSASDIDFATQQLATTGINATIIPSNPTLDMPGRYVDLVNMLNNHPTRDQRKWFVLIDDDTFFPYMHELQRVLSAYDHTLPYYIGTFTERMDWMLSNHAPFAYGGGGIFMSLPTIKQLSQAPCLQKNQDNSYVLNADQGDRLLYNCIHRFTNITLTHLPLLHQLDQFGDPSGFYESGRQPLSLHHYKSWHRFSPEPAHLVADACGEDCVFQRFRFADDYILANGYSVAHYPQGIDFDLELMEHTFEAGDKNNLDLEETVFSYAFGQLRPGLAKTGRKKAWELIGARKEGPGRVKQVYLKRGSDERWQKQPQDSKAGDSVVVLNWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A9</accession>
    <name>A0A0B1P8A9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxoglutarate iron-dependent oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000621">
        <property type="protein sequence ID" value="KHJ34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A9"/>
    <dbReference type="HOGENOM" id="CLU_041456_0_0_1"/>
    <dbReference type="OMA" id="QFFGQHY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="29559" checksum="56FF3080E1CD8F5A" modified="2015-03-04" version="1">MAVKKKLNRTLKPKSPLSSVQTIQLDWPAFTDQLLPKSSLSPETLLPSQIIVIRKFWTENLCKNYVNFLRTLPLVTTGGKLKKGDAIRFNDRFQINDANFAHRLWTETRLKELICDIGTDETMTAHDRNKLWGGEVIGLNPSIRIYRYGKGQFFDKHYDESNMVSLKTDTAITTSANTTWTFLLYLTSASTGCKGGETVFYPNVDLKKGIRDLALEKLVVKLETGMLLLHKHGKDCILHEGKEVLGGEKWVIRTDLCVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R2</accession>
    <name>A0A0B1P8R2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R2"/>
    <dbReference type="HOGENOM" id="CLU_041939_3_2_1"/>
    <dbReference type="OMA" id="ISHMKDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="14"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="49212" checksum="E0EADAB84A4DBFEC" modified="2015-03-04" version="1">MDIHQEFTEWAQQRGLEIIDIKAQNFHGRGMGIMATKDIRANTMILRVPHLALRTQNTVSQVVLDAIKGLQRISVHGLLAMDHIFQNFRGTSNTTATKLTSPAGVAATPIAEYCNIDGGGSNDYSDNNCKPWHNVLPKFSDIQECMPLCWSASLQKLLPPISKRLLHKQRQKLQKDWNIASMAWPHLVYDNYLYAWLLINTRTFYFILSAQSYSGKSHSRINSSRDNNRGTSIHRDDCMALNPFADYFNHNFSPSASVQITKNAFEIHTLRNVNAQEEITICYGNHSNDFLLAEYGFFLNENPWDEVLLDDYIFPLLNSSQKKKLKSVDFLGNYILDRNSVCYRTQVVLRILCLSLSRWEDFVKGLDDGDMDQPQIDQILSTVIIRFRQDIQKILAKISLLDNNYSTQKALLSNRWSQIDTLLETILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P980</accession>
    <name>A0A0B1P980_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001155">
        <property type="protein sequence ID" value="KHJ33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P980"/>
    <dbReference type="STRING" id="52586.A0A0B1P980"/>
    <dbReference type="HOGENOM" id="CLU_017507_1_0_1"/>
    <dbReference type="OMA" id="FCRPMRR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="54074" checksum="8687386B79873633" modified="2015-03-04" version="1">MMPGQEPRRPSLTSRIAHILLPKKPKFRREKSRSESLLPTDYQVHSPNHGAEFNVFNDDINEQTGERRDDTALLHGLSHFNSYDSFDDLEIIDRKEDKRLPGERDIVKLSSELWKKITEYLSISDTMCLAISSKTLLSRIDKKYWLYLKSDRNQDEKLRFLMTLDKELPKHLLCFSCAIYHCRLNIGKERLKSAWVPNPVYNCNGSKKFGLQQPKIRLTHGHFLPFAFVQLATRAEKYTIQHGIPLINLCRRYKDRNTDWSHQTRYHIYKGNLLLRVVSQSFAAHGLPVSAQRHLLYSREDYTPYFSCCSHWRDGELLNVCKCALSHVIEPPIVHQKQYKPMRQKSQSLNLIGALCSFCRPIRRCPDCPTEYMVELKLCEDKADPVVRFKQSIVVTRWTDLGDGSSPFSEEWASINGNATYDSFANLGKRSISAIFESQSGVTLPGQRLISTNPKNEKRGEEGNNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P990</accession>
    <name>A0A0B1P990_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001372">
        <property type="protein sequence ID" value="KHJ33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P990"/>
    <dbReference type="STRING" id="52586.A0A0B1P990"/>
    <dbReference type="HOGENOM" id="CLU_487617_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="559" mass="63176" checksum="EACE4D9A51C8740E" modified="2015-03-04" version="1">MARVTRSQKHQNIESLSSPKCQLYSSKQPRTFSRSHTKDTDFLADSDTVLVNSQKKLKTVRSVESDSVPLNTDRVCTLAVRCLDENQNKLSNYDSSFDYTRKTDKDQDTDRSIEQMNKTKDASPKIHSVESNEDRNALFCLKSKEFIVDEMPKKFAKKSTDLRQSSVDFLVLEGSTMRQNSPESLKVDDGEDSFIAQITSRSPAKPVTRVEDSVEALDQLEIALDVLHEVAKVENMVRHKTHRKLVAPTASEIRPFMTRKINTATPHRNSGLAPASVQSSLKIKHSSLSQVIAKNEMVHSSRKSKNLDINNKKLMPTNASNNFYKSHNRKSHNPKEVSSKTQNDSAETRFTKVPSIKVARRVPTTGLPQVKELKSSSNSRSNRLEDDVFTRLSNGSYKSRSGSKKIDEKMKVAEAKKLSQTANIFSHEDTNSFQDICNVSRAKNRAAKPGRVSINQTSQKNELYSKSPNLTSPQQRLPTLVLSSKQKLDLHHIVDTQGQEIKSDGDEQIIKRRIIPDKEMGKEQRERKPENTALLARAEAAELGRRAVIEWAQKHRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F8</accession>
    <name>A0A0B1P9F8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="JNVN01000444">
        <property type="protein sequence ID" value="KHJ35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F8"/>
    <dbReference type="SMR" id="A0A0B1P9F8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9F8"/>
    <dbReference type="HOGENOM" id="CLU_040058_2_2_1"/>
    <dbReference type="OMA" id="QWMADNC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005110161" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="25479" checksum="FB3D9A8A1AB94B4D" modified="2015-03-04" version="1">MKFLIFTFFTLLIRLTFALPATSNNVTSLQVESMRQIAAFTQNSQSLDISPNATEDGLSGPCKPITMIFAKGTGENGNVGDGSSPGPAWIAEMRKTRGLDMIAVQGVPYNADVEGYLIGGDPEGSERFLNITNLAVEKCPNTRLVIGGYSQGAQLAHNAAMSFSPDVTSRVDAAVVFGDPKKSQPLGDIPPMKVLSICHDGDIICNYIGGSAPHLTYSQDAAKAASFAMTQLQQSSISRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9I3</accession>
    <name>A0A0B1P9I3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000432">
        <property type="protein sequence ID" value="KHJ35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9I3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9I3"/>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="287"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="783" mass="89349" checksum="0B2225365A6D1470" modified="2015-03-04" version="1">MFRLAPSRRWTCTKCLCIRSQLRRKHELALNNSEIHPRKSGLLDHSDPGVKNDDATLRDVFDSVGFWKQFSQSSKNMPNHGLFQNRYLTKIEGFEEFARVSLEKAQRIVDRVLMASTEEQYSNIVKDLDRLSDLLCRVIDLSDFVRSTHPDPKVQDAASKAFAIMYEYMNVLNTTTGLARQLDIAIKFASKSKIWDDQETLVALILKKDFEKSAINLPEHERKRFVSLSQEISETGQDFVVKMAPEKENLCFPSNKLLGMDPTLVKRFMSWGQVTLPTVGTIASTALKNVQDEETRMMIFLASRTSCPKTIEKLHKLLKLRVELAKLTNFKTYAHMTLEDKMAKSPEMVIAFLKSLSKKNKSLVVSELAQLLKVKKLVINKNDVSLQPWDKDFYIYRIQSTIRTKFKRADFLSSFFSLGRVMQGLSRLFHRLFGIRLVPCETLPGEIWHPDVRRLNVISETEGHVAVLYCDLFSRSGKSSNPAHFTLRCSRLIRDTEIEEAIASRNPLFESPIIEVNDGMSSSVTPSGLMQLPTIALICDFPQNTTSQPSLLSFSELTTLFHEMGHAIHSILGRTIFQNVSGTRCATDFAELPSVLMEHFVMDPHVIELFAEHYETGAKLDYAMIKEKLLVNSQFEGYETEIQIILALLDQAYHSELPLDSNFDSSKVYLNIQKEYGVLPSDPEGTSWQGFFGHLFGYGSMYYSYLFDKVLAKKIWSTVFENGKASISRSHGERYQREVLKWGGARDPWKCLSNVLEDERLEHGGEKAMGIVGSWGIEDKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9V5</accession>
    <name>A0A0B1P9V5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hard surface induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000564">
        <property type="protein sequence ID" value="KHJ35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9V5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9V5"/>
    <dbReference type="HOGENOM" id="CLU_005679_13_5_1"/>
    <dbReference type="OMA" id="YLCHIEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="68"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="498" mass="57467" checksum="2DA102319CB3FC84" modified="2015-03-04" version="1">MVYEEKLHLLWDSEPNCIQTIETNKCKLYPGSWKKASLRIFQWILPSFIQCQLFSSTSKPQKLHQTSYLDGLRGVASFIVFMGHYTEENIGWFCEPYGLYEDGAASSPLQLPFVRVLYSARPMVHIFFVISGLVLAYKPLTYIHSQQLLALENCLSSSIFRRAIRLFLPSFIALIFTALAVGSNLSDSRYSYFDGNFFYHFFNALNVCWKLMGASWAIDLLDNGHPEYNPALWSIPVEFSQSLILFITILGLSRCTSIVRLGLHSFILWYCLRSGHLFTAEFLGGSLIAEFILIQDYSLSILQEGPLFDTISSVQTEDLFGKKTSYRFKIKQNLIHLFWIMNIVCGLFIASWTNEHFDEVWGISFLSRNTPEPYDIRNGAKFWFCIGALQIVIACTQLSWLKNILNMAIPQYLGSISFPLYLTHNLCLRILEPIFIPIFEKVIGKTSFWERHLFWIAGLLIYFPVIIMISDLFWRMVDIPSVKFAHWLESKSEAKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W8</accession>
    <name>A0A0B1P9W8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001032">
        <property type="protein sequence ID" value="KHJ34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9W8"/>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="8">
        <location>
            <begin position="117"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="581" mass="64495" checksum="0F1F2D91E637F2FC" modified="2015-03-04" version="1">MSAILSSDDLNDFISPGVACIKPIETLPSKKIPTDEDGLEISLHGEFPFSQDHASLPPAQISLTDCLACSGCVTSAEAILVSLQSHTEVLNELDSAPALRIHPNGTSLENLEHGGKIYVASVSPQSRASLAAAFGVSQREAGYMIEQLLSGSQGIKNRAVYRNFFQWVIDTNVARNACLVLGVDEVLNSLQGREERSASEDSKEPQAKMPLLTSSCPGWICYAEKTHPYILPHLSKLKSPQAITGTILKTTLSKIFDISPQRIWHVAIMPCYDKKLEASREELTDHSWAGCESKGIRDVDSVMTTRELLLLADVRRVDFAKLPRYPVQRIPFPDPKLESFLFPSDKNLLSNRSYEFGPSGGYLYYILNYFVSQNKGSKIHMTRGRNADVLEYSVISCENEILIKAARYYGFRNIQNLVRRLKPPNQSRIPGVKPKGIVKKSLSMPSGTDFTYIEVMACPGGCTNGGGQIKVDDPVLSIHHNSEANSRPLSQKEWISKVDEAYFSGDDILDETQNNNQHEEFVDGISRGYIKEILAHWANLTGIYLPRLVYTTFRRVESDVGKKIDHSQNVMRIASKIGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA55</accession>
    <name>A0A0B1PA55_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001363">
        <property type="protein sequence ID" value="KHJ33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA55"/>
    <dbReference type="STRING" id="52586.A0A0B1PA55"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="310" mass="34386" checksum="158A9DD727FF19A5" modified="2015-03-04" version="1">MRNDKNSKKSNSDKSDFRLFVRLPLEHEWLKLSPTGIREMIVKRLSISPASIGLIKPVRAGFAPSPYSIEARENILKASGRLFLSGAKLEPATQWTPLLIPTVPKIINSLKGRKEISKLMLADEIERVSSLRPEAVKVNGCQKPDAPHRTWLALFTKTPKPGFRVFDESGISSIFKKQTPIEFCKRCNGHHSSKFCSRAPLCGNCGSTMHTQDVCMAATRCKNCEGPHWSDSPKCLARSTRQGAPTKQQLKVYHQAGDHEFQTAIRSRAAVEKASEMEALIGNSENGNPVPEVNETTIISLPKSPEAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAB4</accession>
    <name>A0A0B1PAB4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000975">
        <property type="protein sequence ID" value="KHJ34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAB4"/>
    <dbReference type="HOGENOM" id="CLU_1379043_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="198" mass="22012" checksum="162253E8BD2404B5" modified="2015-03-04" version="1">MRLYPALIVTFVIFIELISSLSYTKSLESRPDPVNLLRRKLLLSSSNILLSNHRKRLLFRGKDSRPGVKCNSSFYKQSRVAAVAEKACRDAFSSCGYLSRCSPLASYFKTTSKRFTGSPILFPEEDGEPLFMVRITKNFFSLDGFKAFLNLGKKDYIIFGGTCTSVGIVREISPNNFAKCEAVNGGSMVHTPAGLNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC9</accession>
    <name>A0A0B1PAC9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001330">
        <property type="protein sequence ID" value="KHJ33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC9"/>
    <dbReference type="HOGENOM" id="CLU_2656304_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="76" mass="9207" checksum="2963B9F9B9EED0B5" modified="2015-03-04" version="1">MYCPEWAKGRGDILRKAKDRSFKAMMNSPEDISRITKWIQKEGWLEQFRLSIEVERVVGQRQEERTKGLRRNSHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAF0</accession>
    <name>A0A0B1PAF0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative adenosine deaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAF0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAF0"/>
    <dbReference type="HOGENOM" id="CLU_022829_1_0_1"/>
    <dbReference type="OMA" id="YQPRQTM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="279"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="613" mass="70134" checksum="E8738D9230A52844" modified="2015-03-04" version="1">MSYKIIVVDVFMQYLKLVLKRIFSVSKSREMPQDGIKNFDTHSVSWESILGDGEFKDQVAYDEALQDLVSLEKRGGFDAEVIATSSEIEVRAARILKKIIALDDEQVYRRESDVMGQEAEKRCRGRHFLGNVDLINKTELIKVAKKMPKGAHLHIHFNSCLSANFLVHLARNKDAMYISSTLPLTTTENMALAQISFMVMTLHEATHIINSEGVEVLVPLGNVWEEDYIPNSWMPYEKFHTQFDPYDKWTGKGKNYGLERTLAAETWLVEKIQFSEDEAHNSKQTCNGIWEKFNHRTKMMKGLFAYESAFRLYTDACIRDFVEDNIQYAEIRPNFMKSNSLKKDDGNGSIGNQGILEIVKDQTNKTINELQKEGKFFGGLKVIYCTPRSFQREQVAYALNECIELKRKYKDLICGFDLVGHEEKGNQLRLFIPEFLDFRKKCKEEGLDIPFLFHCGETLIHGGKVDGNLYDAILLNAKRIGHGYCLARHPLLMEILKKKGIAIESCPISNEILGLTSVISGHHLPILLANNVPCTVNSDNASFYKSSLSHDFYQVMIGSEAMTLQGWKQLAIWSLDHSCMGANQLKIVKKEWSKRWDEFCLWIVQEYGPLVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAI7</accession>
    <name>A0A0B1PAI7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAI7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAI7"/>
    <dbReference type="HOGENOM" id="CLU_372634_0_0_1"/>
    <dbReference type="OMA" id="RRADRYM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="746" mass="83964" checksum="EA34C665065C3CF9" modified="2015-03-04" version="1">MWPFTSREMLPHRQRHQLASSNRMRDEPDGTMQGHPAFKHKCPVAKAHVCQDSNRPRRVSNKLRKDHRHTICSSSDRPRIVCPKRASYPPRIRPSNITKNTSSSQQLPKVMLECRASKAQKLFESTEARSRRSKLQKKGGNNLPNKKSHIKNANEHSERACVKDMATYYSTQPLVATTASVNSAGLRKRKRKINRSGEKYPPDSSPSTSLDIHLSSRSSLSEPSNKATAYMLSTLDALSARPTIKYASKPRYVPPSSHTTCGLKNDDIRIRRTTISEAELMASKRVDRLADRLSAHELRELMERDKKRKEKKKTAELARMERRLNRCAEIQTSSSATDHHEYFTEHRPQKNAQRPHLAQNMSEPIFGSKQKNLGHFEKRMGIHNSGSFNAGKSVNKLSDPITQCPTIADPGSDKTILTSTLKRVDPVDETNPTKKAKRTSLTQYLTLRFSTCSAASTLPTEKINKPHLKTHQYWSIFKLGSKNKRESIPPSFSTTSRESLPSGIAPHSCHTPMRSVSSIPKRTVSKFREDLPDFSISSQSPRTISSETQELHDRTSKPKINEPVIEAKPCCRNVLTNDQNNCNFKKKANRISASGHIDRVGTFQDHKSLSQSLAPADSEASWLSSGRRRLKKTSKKAQKSLKSKSFSKNENYQQCSGPATKEKATLIDKEDYFSRRSTDNSDIYAQSSVDRGEEASSENEKWGAVARQPHIIHSSSAAHRSRHGTLNEIEVDSPCISLETSKEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAJ4</accession>
    <name>A0A0B1PAJ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phosphoribosylaminoimidazole carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Purine metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001115">
        <property type="protein sequence ID" value="KHJ33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAJ4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAJ4"/>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="45117" checksum="05BE280FB276AEA4" modified="2015-03-04" version="1">MDQTIGLLGGGQLGRMLCEAANSLSVKIVVLDAPFSPAKQVHSCIPHIDGSFTDPEKIRELARRVDIITVESEHVNTHVLEEVAENGIQVIREDGSTTLKRVQVQPSWRTIRIIQDKYQQKQHLKAHGVQTIEARPIGSKIDELQTTSQIFGFPFMVKSRKDAYDGKGNFVVKKSDDFEEALEVLKGKDLYAEKWADFQMELAIMVVKFEECVTSDTSATVAYPVVETIHRDNICHLVYAPAREVSEAIRQKAAELARKAVGSLWGRGIFGVELFLLKDGGLVINEIAPRPHNSGHYTIEACPTMSQYKSQLLSVLGIYPSFSDSVISMVVPAAIMLNILGGISKTSHEVLAQKAREMIDAGLHMYGKDSRPGRKIGHVTVISNTMHQAETILLPLIQLANNIRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAS1</accession>
    <name>A0A0B1PAS1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000434">
        <property type="protein sequence ID" value="KHJ35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAS1"/>
    <dbReference type="HOGENOM" id="CLU_608586_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="399" mass="44074" checksum="87DFB0031777ECE7" modified="2015-03-04" version="1">MKNLTKSAPNPLLLKHTILTTLKGDDLSIRAYKLIIEESIVIIEQLQKLNLTALKPSQNVNPPNSKANHTVENLIMNKILQEVQIIKATISHTQGLPRTQGQSWATVASKPEAPGTIIRIQDEEEKKAIAKLSSEELVMKLDTKEVIGAKQMTNGQVRVYFADHDVKEMMETQRGWTTKLAPTAQIASKSYQILAHDMPLSFDPSNEGHIKELEQANSLYLQGIKKQRATWLKKTALPGKTAGSLILWFQQAEHADRAISKGIMWRFELKATEIFRSGFRALQCFKCQRYGHIAKMCTAESKCGKCVGDHNTRESSGSRKRRAGLAGPQIVGADGEIIERRGPGRPKGSTNRIPNMTIGAAMTPSIPSVPILTTPETSQTVTRESTTEASDAPLCTMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW0</accession>
    <name>A0A0B1PAW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000250">
        <property type="protein sequence ID" value="KHJ35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAW0"/>
    <dbReference type="HOGENOM" id="CLU_014831_4_0_1"/>
    <dbReference type="OMA" id="WSKNTDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="276"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="592" mass="65618" checksum="9D8BB7F7A668A33D" modified="2015-03-04" version="1">MNTPPMETPPGSRTPLSAENQEARGKQCDESIPVKGSEGNLQQNDISLLNTADKALDPNVLSKALLKECESARSYCDVTPGASPSRKRQRVYGDRFIPNREGQDLLASFSLLHDDGAPTTPSKEKSRILRGELHFQKTEEANRTFSTLLRSEIFDTTIPQSLAPNVPPDISSHSTKTHDFSRSHTRTKSSPNVLSPTSITPSTPHKNLFSYMSPRHHTNIAGHPTPSRTPHHRHAQTPNSISEIYSLSPVRLGSQQILLSPKKQPRPVNKVPYKVLDAPDLADDFYLNLVDWGSSNSLGVGLGNCVYLWNSQSGRVNKLCELSDDSVTSVSWIQPGSHIAVGTGKGLVQIWDAEKLRRLRTMTGHTARVGSLAWNDHILTSGSRDRLIYHRDVRAPDQWLRKLMGHKQEVCGLKWNCDDGQLASGGNDNKLIIWDKLSETPLWKFNDHTAAVKAISWSPHQHGLLASGGGTADRRIIFHNTLKGITVNEVDTGSQVCNLAWSKNSNEIVSTHGYSQNQIVVWKYPSMQQVVSLTGHTYRVLYLAMSPDGSVIVTGAGDETLRFWKVFSRKPGYNPDNDADNDGRLSDWSVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB94</accession>
    <name>A0A0B1PB94_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g3056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000990">
        <property type="protein sequence ID" value="KHJ34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB94"/>
    <dbReference type="STRING" id="52586.A0A0B1PB94"/>
    <dbReference type="HOGENOM" id="CLU_889016_0_0_1"/>
    <dbReference type="OMA" id="RNDSIMK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="34502" checksum="6A58D52053C9CC2C" modified="2015-03-04" version="1">MICDTQGLLIQIGDVASGLWALAIALHTFFNIVGQKNIAHRTFVTLVLLLWSFILILAAIGPIRGSEDFFVPAGAWCWVNNHNHTERLYFHYLWIFASELGSVALYTFMFYYLRIRIKTSMPQKIVANSNTCSSPAVNISFVQHNNTLLSAKSTTLTPGVQNLKSFSASRTYILKSSRHMVIYTLAYLTLTLPLAAGRALNMVGKEPPIGYFTAAGILIACSGFVDVTLYVGTRRLLLTSTVARESMDGKDGNGKNPIFGEHSERNDSIMKSENDSNTKNLEATLSLMKLEAAITKPFSYCDKGESGKVGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF3</accession>
    <name>A0A0B1PBF3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative serine threonine protein kinase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g3915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001117">
        <property type="protein sequence ID" value="KHJ33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF3"/>
    <dbReference type="HOGENOM" id="CLU_872076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="14">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="13">
        <location>
            <begin position="199"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="36458" checksum="B02E2B3BB3073B07" modified="2015-03-04" version="1">MGALRFSNAELQEILLSRGIEWHKSSLHALEQNGIAERNVRTVIEKMRVLHIQSALPLRHWPLILTAAINILNMIPNKVAPKSPYYAEFERLPNILILNSFGCQAFWLEPDQKKLISKAKEGIYVGTEFSGGHIILNPTTGRTVIRRDIRVHDDVFPYRNKILSLKSNNRHVIHMALSRPRAKDWNKAIDIEIENMTRNNVWTLVPRSEAKDKVMTVIWSLKENPDGQLKARWCARGFSEPYANNTYADVLPPTTMRMLFALAASRNLNISHVDITVSFLHAEIDTPLYIEQPHGREKPGNLICKLKKLIDGLKTAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY7</accession>
    <name>A0A0B1PBY7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cell division control protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY7"/>
    <dbReference type="HOGENOM" id="CLU_1688036_0_0_1"/>
    <dbReference type="OMA" id="YMNILLD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="156" mass="17465" checksum="D032DE9CEEE52C42" modified="2015-03-04" version="1">MNHLLDLLEPINCPAIQSATIITLVCALIETPQNTRTFENLDGLLICTSLFKSRETSRDVKLKLVEFLYFYLMPEVPPTTSASIKSRGLDLQKHNPCDSDDFLGNVEVDERENIRNQTEVTRSTQEKQALLGQYLHSVEDLVADLRESAPFGGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB4</accession>
    <name>A0A0B1PCB4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000575">
        <property type="protein sequence ID" value="KHJ35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCB4"/>
    <dbReference type="HOGENOM" id="CLU_011638_3_1_1"/>
    <dbReference type="OMA" id="MSRNHEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="55"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="603" mass="66873" checksum="283AA59B9143B78A" modified="2015-03-04" version="1">MNSIVVPGRMAPYNPVVHSTASRPAYGAPIPLSDTQAPAGTFVPGTKIQVGSQKVVIQKYFSEGGFAHVYLVKMPKPIDGTDIAILKRVAVPDKEHLASMRTEVETMKKLKGHRHIVTYYDSHASQLKGGGYEVFLLMEFCNEGGLINFMNTRLQNRLTEPEILNIFSDVAVGVACMHYLKPPLLHRDLKVENILITTKGGKRKFKLCDFGSTAPPQPAGSTSAECRSIEEDIQKHTTLQYRSPEMVDVYRKYPIDEKSDIWALGVLLYKLCFYTTPFEAQGQLAILNASFTFPDYPIFSDRLKALIRSMLREPPKLRPNIYQVLREACLMQGIEVPIKDIYSGKDLLDLGKNAKEIKEQLPLSAGAVFTTPLTQPTIIPDVVPMRRGRPTGPSSGQIQISNPSPQRRAVTNDPWAALDSTPQIIIDDVLTRFPSLDQFSLLHDGGKYDFDKNSSDTKKNISKRVTEILADDAFAIQTKQPVSKAQEIISKNPELQAVSNSRVYKPAPIPAHPRQIPSSYVAPGKIPSMLPTSYETKNYPLISPSNQPFPQDMSRNHELNTLINFSDSSPSKKLSQIPLTSQTSSSSSFDTINLSSNDISSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCK1</accession>
    <name>A0A0B1PCK1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="3 15">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g4777</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="3 15"/>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCK1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCK1"/>
    <dbReference type="HOGENOM" id="CLU_027287_2_0_1"/>
    <dbReference type="OMA" id="VQQKNYW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021162">
        <property type="entry name" value="Dot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017570">
        <property type="entry name" value="Histone_H3-K79_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="17">
        <location>
            <begin position="168"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="398"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017570-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="506" mass="58127" checksum="71135D9F00A2E978" modified="2015-03-04" version="1">MANIFNNKSFQIKATPGVIRTERVRDVSKSMLKLSKAKSGMKSHKDKKADTDCSPFKTKCPNSDPQVHYTHKKIKGDLTKRTKQAKKRFHSEYQALNSDTSDSDNCVEFEIKSNKRQKLTIHTDRKRKLWSEDAFLEGFSRYLGMIHAADIPSGELCYKKKLESMETIKFKLNYPGSSYSERYALIFGNDFNPAEEVITVIKIALDFYWQENQIDLVKDPDKGIVRKLTKAYNLFAKNLSNKELLTEFKYQVELYNSLVDEERLKGTFSKNLDLVHEIPLCMVECILQQVYIRAVSPRVEILKKYENGTDNVYGELLPPLVSKMLREAGLTSESIFVDLGSGVGNVVLQASLEFGCESWGCEMMENAFTLAEAQKKEFDMRCSLWGIMTGGVFLERGDFLENRKIHSVIQKADVILVNNQAFTPDLNQKLKDLFLDSKDGCRIISLKSFVQYGHQIPNRNLWDPSNLFDVTEREYHSRSVSWTDAGGKYYIAKKDEKRLMNLTEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM9</accession>
    <name>A0A0B1PCM9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000894">
        <property type="protein sequence ID" value="KHJ34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM9"/>
    <dbReference type="HOGENOM" id="CLU_1035094_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="30393" checksum="C13AD5E52DA56703" modified="2015-03-04" version="1">MNPQLPLDIFHVPAKSKSSPSRGAGVNAQYALHVWDSQEDSHNPSFPSELPFITAGLNRLRSHITFPSAPFFHEAPHDWPREYRVKGSILSQRTPDQSKLLAQMVGFWLDFLEVPSTNVLHSKFIPFHPEEPCLLDNKSNTKLEIKFGIIEFNRSKISARGYQESYRNSWNRPSLFPYPIIFKAPPQILKRALSPDPPDVGNRVSKPTPSTSRTNGNSITKVRSSLNVVDALRKGIALEMTFGAAQFSDTEQVQVVPMECEQVTDQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCT8</accession>
    <name>A0A0B1PCT8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative interferon-induced gtp-binding protein mx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000728">
        <property type="protein sequence ID" value="KHJ34736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCT8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCT8"/>
    <dbReference type="HOGENOM" id="CLU_008964_7_3_1"/>
    <dbReference type="OMA" id="TDHYISQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="3">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="74261" checksum="9E8D983EE522C664" modified="2015-03-04" version="1">MTISRESKLVTDSLENFQTEEQRSVLDTISNVRRCGLDGVLSLPQIVVCGDQSSGKSSVLEALTEIPFPRSDNLCTRYATEIILRRAENSSILIKINPDDHRPAEEQEMLRNFAETITDFAELPEVMDMAREAMGIDSELSSNPGCNAFSRDVLSITMEGPEVPQLTLVDIPGLIANATLGISDADVEMVGEITNYYISQSRTICLAVISATNDYANQSIVTRIRKYDPLGDRTLGVITKPDRLEVGSANEKGFINLARNQDINYKLGWHIVKNRSHAEADDSLVQRNISESTWLRNSNFNVLGQENLGIGSLRKRLSKLLFEHVKLELPKLRQELESRLKGYKQDLAAMGESRATPSECRSFLIALSQDIREVCVNAVNGHYQNEFFTQKSELINCGTDVDLPITRVRAVVQCINTSFAEHFKTYGHKYQFSIDNHGFLSDDDPKVPPSKSWIEAPIGMNKSATMKWISIAINNGRGHELLGNFNPLLVGELFWEQSSKWKILGQDHIENIFEKCTKFLRTLIQEKCPADVASRIWDNFIIEKLNFRNSQAMRELEYLLRDLKRFPINYNSEYVKYIQKKRQIRQQELEKKYVKREENNDDNPVHNFVYDPETMEPEKFTCDEIFSSLLAIYKVSQFFTSYQISISINQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY2</accession>
    <name>A0A0B1PCY2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ubiquitination network signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000703">
        <property type="protein sequence ID" value="KHJ34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCY2"/>
    <dbReference type="HOGENOM" id="CLU_005822_1_0_1"/>
    <dbReference type="OMA" id="NNAFWQP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="678"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="942" mass="104220" checksum="F9358586B85A85B1" modified="2015-03-04" version="1">MPRGSTTTKRLRGTAATLANTSNDSSIVSASKRTRKQKNNGRINGHAKNPHNNSTSTSPPSTPQSASDRYEQYLGLNDKKMDIMMDSDLVRTDSASYSDSSSESYQNASETPIPENYRQIDVNATKNLAVHRDLGHLSFAITILRSCPLSDTLAILIVLLQIPPTFLSIIQLLFVTLTFVPSTSVATSGLSNPEFLQGTIGTPTLTTILFLDFAVLLIWLFFWTPMQEMALDMAQAVIAITLGGASSYKGAGIKIFFWCFSIIGASHFFRNGSMKNQSFREIISSNYYTTSDLDDPIGPVIRSNGKKYGLIRVVLAVHILTQGVVRYVWDFYIRKYNQEIPTTFFRSTKIENLEMDLSSVSPMSPTRESEEITPLENSQAKFKSDNLSKGCASARNRQPLWAALASTKIVMVKEYETSHAAAESAGANTSRMNNLGSAPFSSEKDKIWITYVGSDEIFFSTSFFSAFCPCNQDEAAILENSTTEKLKPFYIKVNNASWQPIKIYTMTEAAQKPGPSTRWSGVIFGLSPMSNYNFDFISTVDKSVIFSTSVRTLQSPISELGISYNAKNVTHTSSPYPALKTSIAQVGKKLEEDRQRQKSSRKELRAKINSVRKEFERLLTSIASTGGNDDKMRQKIQQSTLHMKQADEATTILVTQIGNIDSIPANETSLYSESKNEIQLQREKHKNIDSEINSYKQNAEREIQALKSDLLNLKQKSESRNQRLNILKAKYESVLDANSKGLDEAQRRESEREVKRKDRAKIQAFYTERLQSINSEIFEGQAAHQTVAAAIETLFQVQQDIYSGHSPTLSSRNSSGLGGDSVSINSSIKPGSYPWTVPVNCSNSFSGSSVLPLTSTTMPSLKQGNRNRGRSSSMLSNVSKFTQYSDDGPLLSFLGKKLLGWEDTIEDLKFNSGSANESKYGAGSTPDVKSPILVTGEVASNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD32</accession>
    <name>A0A0B1PD32_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease mrp protein subunit rmp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000677">
        <property type="protein sequence ID" value="KHJ34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD32"/>
    <dbReference type="STRING" id="52586.A0A0B1PD32"/>
    <dbReference type="HOGENOM" id="CLU_031977_1_0_1"/>
    <dbReference type="OMA" id="VIPRCYI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="246" mass="28058" checksum="0AFC8E386E0149BC" modified="2015-03-04" version="1">MEGENLLSSIQKLQNISQLLHLAHHRNKNQHRVSRWYKYFGQLRRQISKLILELDTFATAIKVACDVTTTNTSESVTTNKYVLSAKKKIEQRNKFLHKILLPKCYLAFGNLIADNQYAVLGIMLMGLLASVNNILSTLPISNQEEKISDSIEHEKTIDASVIKDNRLDDLGEIVSRQDFNAQFPACIKNGKMGEKSVASKASKKQKKRDLVLESKVEVVKLHSKAKIKKRDTKKDDFFDDIFKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD39</accession>
    <name>A0A0B1PD39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative tyrosinase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000669">
        <property type="protein sequence ID" value="KHJ34821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD39"/>
    <dbReference type="STRING" id="52586.A0A0B1PD39"/>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="NGYCTHV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF32">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059567" evidence="5">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="7">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="605" mass="67945" checksum="866BF77E355E5F1E" modified="2015-03-04" version="1">MKVIPNIILLIVFPLGALTIKNKFQESSLPSYDYDSLTPLIKVRQIPSTIVTRGASGGQGSNRSIPLRREVRELEKDEDAWTLYILGMDLIQHIDQSERSSWYNLAGIHGRPFKPFDGVEGNSESGYCTHISVLFPTWHRPYLALYEQILSEMIKDIAQKYPEGGIRDRYVAAAANFRIPYWDWAANRFDGESVLPKIFSESSGISVDGPVGRQIIANPLFSYQFLPLDPEQLPNSPFNQFTGTMRYPDNNNSLAVSHNNIATQALESNAASVRSRIYTILTNYHSYLAFSNGGYRAEAPPSEQDSLEAIHDQVHALVGGGGHMSFIDYAGFDPVFFMHHAMVDRCFAMWQILNPDSYVTPRIAVTSTFTLPVGQVQDTNTPLTPFFKDESRNFWSSSDVRDIRKLSYDYAETSDANGISREQDVIVAINRLYGPTPGIRRKKKREIDAQSISASGKYREWLANIQMPKSAQNAPYSVYIFLGPFNDDPKYWSTDPNLAGVHTMFQSSMSMERSNDDNSPMVTAAIPLTNALIEKIKTGDLASLSVEDITQWLEANLSYRILGLDGTEICEEDLPDFKITIASADVKLPEHNSEMPIWGEMLEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD93</accession>
    <name>A0A0B1PD93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ribosome biogenesis gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000106">
        <property type="protein sequence ID" value="KHJ36218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD93"/>
    <dbReference type="STRING" id="52586.A0A0B1PD93"/>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="177"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="624" mass="70672" checksum="476E365A983CFC7F" modified="2015-03-04" version="1">MVLAKSKNAVGLGNSLMNDRFGKAKGSDRKKLTASTIQRINHATGETYVTNERQKASWVKMRSVTEQPALDEFLSTAELAGTDFIAQKSNNIKIIHTNEKNPYLLSGFEEQEVVGKQEKFKSCLTVPRRPIWKSTTTPEQLDLMERNSFLEWRRGLAEVQQENNLLMTPFERNIEVWRQLWRVIERSDLVVQIVDARNPLLFRSEDLEQYVKDVNSKKNNLLLVNKADLLTVKQRQIWANYFNTAEIPYTFFSASLAKEINEANLNNSEETNLTRVRGSEQNKEVDEIFESEGTHIVDVNELEALFLRHANLNSSEVSAKINIGLVGYPNVGKSSTINALIGAKKVSVSSTPGKTKHFQTIHLSDKVILCDCPGLVFPNFAKTKAELVCNGILPIDQLREFTGPVGLVAQRIPKSFLECLYGIKIKTKPLEEGGTGIPTAEEVLIAYAKSRGFTRSGHGQPDESRAARYILKDYVNGKILFCHPPPETDSKEFNLDYFKIDKQLSQEISALGERPSKPIVDISQEHLETKSQLLPENGIKSQKLDSSFFVNTQKNAAHLRMPFNYKYSEQGKTDEKHLPQYYNSKIPGLLKDLNIDDAMVLRSKKHFKSGKKGNSKRRLKFFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEB2</accession>
    <name>A0A0B1PEB2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000465">
        <property type="protein sequence ID" value="KHJ35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEB2"/>
    <dbReference type="STRING" id="52586.A0A0B1PEB2"/>
    <dbReference type="HOGENOM" id="CLU_702480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="393" mass="44288" checksum="906AC54856C346D8" modified="2015-03-04" version="1">MGKQNPYCAARLGKEAKKTVTDHRGGQTPKWDQELRYKVHDSPDYYHLKVSVFNDDKKTNLIGETKIDLRDIIFLRGGQNDSWHNLLCKGKYAGEIRAKITYCDIHPIRENPGKPDMITKTSVFTNIIHSSASLQSLKTPDRLSKFHSTCALSPSDDIKYLPYQRKLNKNEIDVADEIGNSQIYAGFWSSSKSIQDNNWAADEVADENCAEVDKNVPSSLSQHAAGQYELLGNRPKQTEQLGEIKHCEQQKSHNFNADFPYKFPLAEELGALPDQGNSPPPPSIHRCRKTKNILPPTQFPTSNPSLASIQSPTSHSHRYSQIPQDPHLISSLAHGASNPLRKNDQYPFREIFNAKQHQENYQCSPSGGYQELPAQGYQSSPRHHKGNCHSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEM0</accession>
    <name>A0A0B1PEM0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative succinate fumarate mitochondrial transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000430">
        <property type="protein sequence ID" value="KHJ35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEM0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEM0"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="236"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="37328" checksum="2D22D3295A85B944" modified="2015-03-04" version="1">MMTQKSSSCNHIVKRPTSAATNFIAGGTAVCLNYTTDFWAIKLDTIKVRMQLSRRSQAPGTQNRGFIATASSIVKQETTLGLYKGLGAVMTGIMPKMAIRFTSFEAYKRWLDNKYTGNISNHSIFIAGLAAGVTEAVAVVTPMEVLKIRLQAQNHSMADPLDIPKYRNAAHAFYTVFKDEGPSALYRGVSLTALRQGSNQAVNFTAYTYLKDFLQKRRTSNEISSGISISSQSSILPAYQTTLIGLVSGALGPFSNAPIDTIKTRLQKSPAELGQSAFRRISLITLEMWKCEGVRSFYKGITPRVMRVAPGQAVTFTVYEALKESLEGKETIIEAGKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFK7</accession>
    <name>A0A0B1PFK7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000431">
        <property type="protein sequence ID" value="KHJ35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFK7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFK7"/>
    <dbReference type="HOGENOM" id="CLU_594741_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="460" mass="51144" checksum="ACF2415BED5935DB" modified="2015-03-04" version="1">MKIIKFREESLWTKSQHKIKVQENIRLWIKFENFETKNANNFKLIANANEETVESKVWNAKTFKNIIDRSVGLQQPSPEVWKSLKEFSEVVPLSSSRKIGSNLLDSGKNSLQTFKITSTKLWSHSEKQVKEINWISRSCVTQDQKQESKPKSESKTNGYLWKKKSVVLKTSFLGIDSSATFQPPSYPTEATLDGNTSTYRPKFVRLPLDQITSTKLWEKSINIPIQRDWISESSVRPESPTFSTSSSVPSSPNSDASSIFSISTKASSIWAVQEMPSRTAVPFVYPFISEVNPSELKLVQDSHRASKISNGPKLAKPTSLAAVLELNQQFSPKSQKKNDNQTPKHGAYPKKKSLKGVVSEEKDIALALSISKSTDPPTRTTATTPTDWKLALEEAILAGKSTNPPTRTTATTPTDWKLALEEAILAGKSTNPPTRTTATTPADWKLALEEAILAGKSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFQ5</accession>
    <name>A0A0B1PFQ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cdp-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000414">
        <property type="protein sequence ID" value="KHJ35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFQ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFQ5"/>
    <dbReference type="HOGENOM" id="CLU_051314_0_2_1"/>
    <dbReference type="OMA" id="RIAMSPY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="30064" checksum="0AF43ED399ACBDA3" modified="2015-03-04" version="1">MWRFCCKHTISERAKFCKIKPNNSIHLRVKSEVNKRNHAIETKKKLLKTFTGLTKHEYIYTVPNILTFSRLIAAPIIGYLVLHDHHTWAFSLFTYASITDLVDGWIARRWALKTVVGTVIDPMADKILMTILTICLAIKGSLPVWLATIVLGRDIGLAIAAFYYRWISLPPPRTLARYWDFSLPSAEVRPTTISKYNTALQLALIGTTTVMPIIAIDLSYTLTIMQYLVATTTIASGASYIFSRDAVKILKVEDWSKTELKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGF5</accession>
    <name>A0A0B1PGF5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000073">
        <property type="protein sequence ID" value="KHJ36320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGF5"/>
    <dbReference type="STRING" id="52586.A0A0B1PGF5"/>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OMA" id="FQAHIKF"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="231" mass="26501" checksum="B9D064473EF4BB55" modified="2015-03-04" version="1">MAAAARQRLLNEYKGFAKEKWVKIELNEDNIFKWLIALIVVNPESAFDGAYFKAEMGFTDKYPYAPPTFKFLQPIYHPNIYPDGRVCISILHAAGDDEQSGELACERWSSIQSVESVLRSILLLLDDPEITSPANVDASVMYRDNLEAYKQRALETVRISMRDIPEGFVMPKTLIEAPPPQINDDDDFWNESDDQDEFGTSESSDDDNYDFEQDEDDDLTELKSTRKMDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGG0</accession>
    <name>A0A0B1PGG0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000072">
        <property type="protein sequence ID" value="KHJ36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGG0"/>
    <dbReference type="HOGENOM" id="CLU_2401311_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062140" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10066" checksum="FABF248AD0F35D36" modified="2015-03-04" version="1">MLKLFHTGIAGLSATCTALSIRPQWWVVGGVTIPCLVGRFRSGHHTSDPKVATETTHASIAITRGFGTAPLKTGFNLRKCWAIFNALLHYVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGS6</accession>
    <name>A0A0B1PGS6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000012">
        <property type="protein sequence ID" value="KHJ36460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGS6"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="91" mass="10061" checksum="0383B19817B32245" modified="2015-03-04" version="1">MHSQDVCMAATKCRNCGCPHRSDSHRCLARPTRTSKPTKEQLKVYRKAGDREYQVVVRANAAEARALSAEQSDGVNETPNSSQISEINAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGU7</accession>
    <name>A0A0B1PGU7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5882</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000282">
        <property type="protein sequence ID" value="KHJ35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGU7"/>
    <dbReference type="STRING" id="52586.A0A0B1PGU7"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45206" checksum="DA71043B2E8B1BDB" modified="2015-03-04" version="1">MLHKLHIQPESYDKKSNYRFGRTLGAGTYGIVREADGPTGKVAIKIILKKNVKGNEKMVYDELEMLQRMKHPHIVRFVDWFESRDKYYIVTELATGGELFDRICEQGKFTEKDASQTIHQVLEAVDYLHDNNVVHRDLKPENLLYLNNDPNSDLVLADFGIAKMLESQNEILTTMAGSFGYAAPEVMLKKGHGKPVDLWSLGVITYTLLCGYSPFRSESLPDLIDECSTGKVIFHERYWKDVSNDAKDFICQLLQSCPNKRPTTKEALQHSWIIGESATDHNILPEIKAYMAKARLRRGIEIVKLANQIEALKLQVDEVDDPDVPSNAKSAAAAALAGPAEESQSKQTTSRNRSPLTHAAKAAIFREIVLAKVREMKEVEKRIQVEKDAQINAAKRNSSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHJ0</accession>
    <name>A0A0B1PHJ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000166">
        <property type="protein sequence ID" value="KHJ36009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHJ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PHJ0"/>
    <dbReference type="HOGENOM" id="CLU_093520_0_1_1"/>
    <dbReference type="OMA" id="GCAVGHT"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="154" mass="16169" checksum="E0A9E7488A806EA6" modified="2015-03-04" version="1">MPRQSRSGGAGRAPSRPTIPARKPIPQNQQQTRPATSVAQAPAQSIAPQQQSSAVPGLFGQMASTAAGVAVGSSIGHAIGGLFSGGMSQPAAQSQTDAVANPNNQEQQNDWGSRSCDVDARQFTKCMDENQGNMQICSWYLEQLKACQQAARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHN2</accession>
    <name>A0A0B1PHN2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative fungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHN2"/>
    <dbReference type="STRING" id="52586.A0A0B1PHN2"/>
    <dbReference type="HOGENOM" id="CLU_138059_0_0_1"/>
    <dbReference type="OMA" id="WLHVPME"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="17415" checksum="BB1BF0F08E693B98" modified="2015-03-04" version="1">MELADSTLKYTPFPTAFKQVKGSVGNIETEATSTYFADQILITISQHGCLSQWIEVPISSSVAASFTKLGAQYTQFPSGNGDDEMELPESHLTPKTLLGSGGEQRENIAHLFAMNIASSIVKKNPEECRTILVGLGLEKVVLQREDFFDMMELLHVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWL2</accession>
    <name>A0A0B1NWL2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of ploidy protein mob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003674">
        <property type="protein sequence ID" value="KHJ30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWL2"/>
    <dbReference type="STRING" id="52586.A0A0B1NWL2"/>
    <dbReference type="HOGENOM" id="CLU_038321_3_1_1"/>
    <dbReference type="OMA" id="VDNEQMF"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25289" checksum="692B05912F6791FC" modified="2015-03-04" version="1">MTSFIPTINQRTRNQFRTRNTPKGTTSFQLRQYAEATLGGGSLRKIVRLPEGEDENEWLAVNLVDFYNHINLLYGSITEFCSPQSCPEMKATDEYEYLWQDPENFKRPTKMAAPTYIEHLMGWVQSSIDNEAIFPSKTGVPFPKSFPSIIRQVFKRMYRVYAHIYCHHYPVIRELGLEAHLNTSFKHYILFIDEHHLASGKDFWGPLGDLVDSMLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXZ6</accession>
    <name>A0A0B1NXZ6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003569">
        <property type="protein sequence ID" value="KHJ30813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXZ6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXZ6"/>
    <dbReference type="HOGENOM" id="CLU_027589_1_0_1"/>
    <dbReference type="OMA" id="WNASKDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="392" mass="42858" checksum="8CDBAFE973EBDC31" modified="2015-03-04" version="1">MTVELEQTAHLTLTNMAAHEPQYIVFIRVPFPRSDFVDPPFVDWDAAKDKQLWKILSNTSKNSNIDWNKLAMKFDVPLTFLLQQIACLYEQQMQQVKAQIRKVRETKGLSVSPVVPGAKSDSGGEIVKGSQVAVGIAQETVHSTRTGPSIGSRISPILPHRKDTTGQITTSNNAIHLTAPLGSRKRSDNTAIESLELSPRPHSSTLYQESASPKLQVRLSSGANLLPQTSPSEIQSSSESSSTESSSDSELSTLKSVLRRPTRFTPKPGHDKYAHDEEDELVFMPLAKEGMTYQNLISNTDSINKKVSKPELDTSTDIAQQPDLSNLLMSQIKGKGREVIDAAPSMGSSFSDLEDTSITQSALEEALASKMQAGGMASRMSSISQALRSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYL7</accession>
    <name>A0A0B1NYL7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tumor suppressor candidate 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002864">
        <property type="protein sequence ID" value="KHJ31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYL7"/>
    <dbReference type="STRING" id="52586.A0A0B1NYL7"/>
    <dbReference type="HOGENOM" id="CLU_014995_3_1_1"/>
    <dbReference type="OMA" id="IVMHKPD"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="417" mass="47954" checksum="0FFAC7A1F692D937" modified="2015-03-04" version="1">MISGIFYARFLPEQGTKVVNQSPTGSIVPEAEVDKPCLFDFEKLAEYIIPRQVFCNHYIMVCDPQSTYRILGHPVCIQDSKYKRNEFIFNFCVVIKADTDPSPYETVVRRLASTFTEMELQNQFLSEKEKQPNGISVTQGGRSIAALLEIIKEDLNNYNECMIPVDDANTINLKLFPIRRPPPPVKSWQVPVPKINLLQRLDDTWDLTLAKVTRCIDGIREVRRVAIESNVPIELTKVALQHLLYYDTILMVDMFFFSNIYAPNSFIGEFIANKDDMQDECLNYVCINGPVVDKYYLCRLFTSLGPGRSLIEWLKFHNKEGFEVINYIDVRRFIQFGIIKGFLYRVHAYALSSQCITALKRDISEKTGLTEEESILESYSDGCHCIDEVTVEMNLSKNQIVEKLQELSHGDADIIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYQ0</accession>
    <name>A0A0B1NYQ0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004936">
        <property type="protein sequence ID" value="KHJ30160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYQ0"/>
    <dbReference type="HOGENOM" id="CLU_037437_0_0_1"/>
    <dbReference type="OMA" id="QWRHLFR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="43332" checksum="7D731B77EE0A69F7" modified="2015-03-04" version="1">MEEIHIRSINLYRSLLRATSYLPDQFARAIIHKHTVHRFKKAQQRAIEASELESRRQLKGYKSILSSNSCLATLKKRLSNGQQKLGVLRRALEGDSDCLLKILMIAYGRVGRRRRELIKLLLTDDAGNIPEDTAALVAILNCQSNVEKLLENRFPKGGPKFNAFLKSQHSCRTKDVRDTIKELEPKILEVNIWGRPLPLKRVNTIKKNWWSMILKKLLPPVPRDEFERLKSLSLGITYQEWLISKRKPAISLNKSDGMKNSLKWLDIFKLPLRDLDETEIDMIKRTPFGLVWDENAKKAPPKYMRPPIQKLIRSHRSMRRLYGKVWSLTATMFKDDISGKWITEWGKGSSKYFAGHVTQPCKRDIELFGGIDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYW1</accession>
    <name>A0A0B1NYW1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002751">
        <property type="protein sequence ID" value="KHJ31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYW1"/>
    <dbReference type="HOGENOM" id="CLU_2346400_0_0_1"/>
    <dbReference type="OMA" id="YIDNDET"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="103" mass="11548" checksum="B81533245A67E71E" modified="2015-03-04" version="1">MSTKHISDEELSNLKDDGWKIHMIGVKNNDDHEYHLAKAKSFVLETGGRLVEDIAAIDGFSAIFPPESAEVFNIYAIDHISFSNEDKDINTSDNPDEKLDTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ27</accession>
    <name>A0A0B1NZ27_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004592">
        <property type="protein sequence ID" value="KHJ30275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ27"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="13588" checksum="801F235F543EF3D9" modified="2015-03-04" version="1">MHTQEVCMAATQCRNCGGPHRSDGRKCLARPTRHGAPTKEQVKVYRQAGDREFQAAVRARAAEGKVSEMEALIGNTGNGNPIPEANKTTIIFVPEISEADEELIHTVDNVTQKSVEVVADSSMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ68</accession>
    <name>A0A0B1NZ68_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004560">
        <property type="protein sequence ID" value="KHJ30295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ68"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ68"/>
    <dbReference type="HOGENOM" id="CLU_991091_0_0_1"/>
    <dbReference type="OMA" id="CHTNRER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32071" checksum="8BFD9F1FDC95544D" modified="2015-03-04" version="1">MNNYTSATPSNGVIILQGTNNYLEWLYTIEMAANCGVHNVWQYINPCHTNRERQVIPSSTEKPKPNDVSATATTVSQLSAIEIDDFKLRLADWKEERAEINEIKLIIGTIQNKVLGSISEKLLPQLKGKSTVSEILLYLNKRFRPTDQARKQEVISKWSKVKEKPKDMAIIPWLDQWELIYADAIELCLPHVIEPQAQYDFLYAMQSFAGSWVELKLAKIEEQVISNEPIYDFYDLIESFRHKQRLNDTFSIKSDNIGGSNSSGVFTASEDKKDTVHKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ85</accession>
    <name>A0A0B1NZ85_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005728">
        <property type="protein sequence ID" value="KHJ30001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ85"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ85"/>
    <dbReference type="HOGENOM" id="CLU_049841_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="170" mass="19521" checksum="2D64059A1B73F40E" modified="2015-03-04" version="1">MACILPAKTFQALIAQLRTSISLSLKVQKSQQTAYYTADGYENDSFYTDRQYHGQKRSQTSSSSANNKEQSKTKFGKKACFVCSKEGCWSTRHSPEERMKSMADFKSKTLRLTGRKYTGPEIRQFLNDFEGLEPAQEIPDNFSHFHVTQDDEESDDLEDFFRTGIFFTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZB6</accession>
    <name>A0A0B1NZB6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome oxidase assembly factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002626">
        <property type="protein sequence ID" value="KHJ31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZB6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZB6"/>
    <dbReference type="HOGENOM" id="CLU_169171_1_0_1"/>
    <dbReference type="OMA" id="CWKRQGN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="81" mass="9491" checksum="BF1AD463CDE4C31A" modified="2015-03-04" version="1">MSQNAVDSKSLATVVDDDDEPDDWDKRIFSTGCAAENTKMNDCFYEKKDWRLCKDELKLFKECWKKNKNDERTSTKNSNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN2</accession>
    <name>A0A0B1NZN2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002892">
        <property type="protein sequence ID" value="KHJ31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZN2"/>
    <dbReference type="HOGENOM" id="CLU_001832_7_0_1"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="369"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="558"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="996" mass="113217" checksum="7EE29970BF8EDDC0" modified="2015-03-04" version="1">MGTKKYAFVPMEDEDLGPVKVVEKKKERHLNHSQKSRQANSPSRSPQRKSITQNGHKARIRRRSINDLQFQERWGDEENVASEEPDFRESAPKRVKTAHQDDSEEELDEEERERIRDQKEKEAFAKRLASKDADKSKKIVEDRSSAKEGSILAHRRALAEDASARTAALPDLRERSRQEYLKKREAERLALLRKQVDEETEELKSGVQLSEKEKAGFAKNREVLRIAEERLRIDDHLDGYSMPEDYITEKGKIDRKKKEEAMYKRYIERDEYGQEKFITEHEEWENEQTAKAKAQIQSLERTDNNYDYVLDEEQGIKWVTDSRLPGEGKVMTKEQRFFDEQLKAAEKKALSIEETRKNLPIYAYRDQFLEALAEYQILVIVGETGSGKTTQLPQYLHEYGYTKGGLKVGCTQPRRVAAMSVAARVADEMGVKIGNEVGYSIRFEDSTSDKTVLKYMTDGMLLREFMTEPDLGGYAALMIDEAHERTVHTDILLALVKDLARERPEMKLLISSATMNAAKFAEYFDDAPIFNIPGRRYPVDIHYTPQPEANYLAAAITTVFQIHTTQGKGDILIFLTGQDEIEAAEQNITDICRKLGSRVPELVICPIYANLPSELQSKIFEPTPAGARKVVLATNIAETSLTIDGIVYVIDPGFVKENIYNPATGMSKLVAVPCSRASANQRSGRAGRVGPGKCFRLYTKWSFMNEMEESTLPEIQRTNLNGVVLLLKSLGINDLLEFEFMDPPPTETLISALNQLFALQALNHKGEMTKLGRQMAEFPTDPMLAKAILAADKLGCVEEVLSIVSMLSEASALFFRPKDKKIHADSARARFTIKEGGDHFTLLNIWNQWVDSDFSFVWAKENFLQQRSLTRARDVRDQLAKLCERVEVVTSSCGANNLVPIQKAITAGFFPNAAQLQRGGDSYRTVKNNTTVYIHPSSVLMDSNPPIKMVVYYELVQTSKEYMRSCLPIKPEWLHEVAPHFHKKKDLEALASKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV1</accession>
    <name>A0A0B1NZV1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4951</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004836">
        <property type="protein sequence ID" value="KHJ30186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV1"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="ATSHRIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="339" mass="38665" checksum="F6A0CAE4BB79C0EE" modified="2015-03-04" version="1">MECLRDQFTKGVILAGRFKTISPLNHGSFGMVFMAEDLENNEIVAIKCLMKKNPVSEADSAFAIDDNTEELKFHARLGNHPNIVNLIHSVETEEHIFLVLEFCSRGDLYEAIRVSTEPLHTEYVRQFMLQLVNAVEYMHRKGIYHRDIKPENIFLTHSGELKLGDFGLATTQKWTYEVMVGSDRYMAPEQFDSAGAGYSPEKVDIWAIGICLLNVLFSRNPFTRPTESDPLFLDFSRDMQSLFDVFPKMSQDTFEVIQQCMSLNPRKRSLDGVRKALERLVSFTTADETYDDFLLAEIRGIASSANREPLRTLSIQTTQNELSGFHWTKNLHSTFAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P056</accession>
    <name>A0A0B1P056_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bax inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003780">
        <property type="protein sequence ID" value="KHJ30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P056"/>
    <dbReference type="STRING" id="52586.A0A0B1P056"/>
    <dbReference type="HOGENOM" id="CLU_046868_1_0_1"/>
    <dbReference type="OMA" id="APMCFVG"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="39184" checksum="F36869885CA71892" modified="2015-03-04" version="1">MTQPILLLRHSTRQLSQNAANLLLGPRITLSSFSMQGLSKAGSTGAARRVHNKTPRTWSWIFTSQRTGLQTWLFKTQNGLGRAWKSHYHSAGTVDNSGSLMQKLVVGGAMFGGTLIAINLVFNRETREDGSMPAYERSYLNDTFLHTGLGIGIIGLSARAMFQSGAMYRMMATSPWIVMIGGLGLSMGTMMATRATDPTNYVAKYGFWTAFNGTQGALLAPLLFVAPPALIARAGLYTMAIMGSISFVGATAKQEKYLYLGGPLLAGAALVAVSGLAPMVLPATAVRTLAISENLWLYGGLAVFGGFTLYDVQKVLMHARMAQQGLLRRDAVNESISLELDFLNIFVRVVQILMMQQSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P063</accession>
    <name>A0A0B1P063_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative int1 protein bud site selection protein bud4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002396">
        <property type="protein sequence ID" value="KHJ32027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P063"/>
    <dbReference type="STRING" id="52586.A0A0B1P063"/>
    <dbReference type="HOGENOM" id="CLU_002541_1_0_1"/>
    <dbReference type="OMA" id="MFAREQK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13278">
        <property type="entry name" value="PH_Bud4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000311">
        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1260" mass="142740" checksum="4B2733DDF0243160" modified="2015-03-04" version="1">MESTSSRALLELSSISSKRNSPIMAKPASNMFNNPDSSPFQSSPLTASIDGKSSPRLFWQGRDHATTPSRLNTENMFIGRDSSPSPTRRTSIEKLQRASRVKNSNMFAREQKLEYDPASVPILERPLSRTLQGNAYNGLGLNGYRKNENTYTSGYKRNDMKGSSSKSPPLSIDSNLAKTIQKLGLNSAKSPVKKQLSPMKSSLSTCRPKSSLNLSSGSRSEDPFLEKKKLPPGKVLHRHTKSVTFDAAPPQVNEYEMATPDISSIGTDSRENSYESVEDEYNHLNYDETLEQDNSFDESLEDLAKTPVVGPEDWRNESPDDHVRKFMEGEIDDPFDELNDYPNKDVKSPILSAWSLRSNTSMSNSSGEQRPLPPIPRGLRLDKFNKSPSLSEDSVLSEQPRRISRESILRKVEGQLSLSGDTDYIFSSPTLNSSLDHRIFLDPDIPIPTTETDFEVDDREDEDHASIISKQEYDEDSDITSYNIPELSVEASQEPQLDNEYNLRQTTQETESHYSEDMPIVNTTNESNISNHEDYLMTNSIVDATHSPASDKNLKENNESKVDINDHGIDISKFRLSLQIESLNVDPDCDIDSKRNSNLETQSRSSLTGEVLAKIERPSTPENGGESCSREEDYESEIGTPESVIHHEIFVPSPCESPSIPDRIATIKSRSGSYKLKTRPSATSVELEEMRQSIVNENEDVPSVPPIPDRHRNRPMSVDRGMMQKLEDTLHEQPGFKRSLTLDISNDLSLNLDNDFERVIQAQKRGYLMRQNTKIVVATSDTRLHDKYNDLHSTDESSIKHSRTRSWVVEPWNGQKRKCSEAVNGVQNGNILTTSRNQESGRSFSGTSAMSEISNLENGDERGRLFVKVLGVKDLNLPLPQNEKTWFNLTLDNGVHCVTTAWLELGKNAPIGQEFELIVPNDLEFQLTLNAKIIKPVPKKINETPSKTFKVHKPSTFSRVFTSPKKRKELEARQREEEQQYAKQREFESKMKKSSMEPTAWDLLSPFTSENGSFARSYVCLKDHESLCFGRPYVVEVSCFNEWATEQINKPSSVMSKRTSTFVQRRAPYKVAKLELQLLFVPKPKGATDDDMPKSMNSCIREMREAEKALALKWEGHLSQQGGDCPYWRRRYFKLSGNKLTAYHESTRQPRVTINLGNACKLIDDRSILTQKETTGRGGKRRKSGFAEEEEGYMFVEEGFRIRFNNGEIIDFYADSPAEKEAWMRALDACIGKEGEFSKRCWCNIVLKREQSHRKRAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P078</accession>
    <name>A0A0B1P078_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002699">
        <property type="protein sequence ID" value="KHJ31648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P078"/>
    <dbReference type="STRING" id="52586.A0A0B1P078"/>
    <dbReference type="HOGENOM" id="CLU_011856_0_0_1"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="513" mass="56518" checksum="FB089CC495CEBE5A" modified="2015-03-04" version="1">MACSPPHMNGNLAKTQSRASELDDLLRAVNPLIISFVQASDEPTSRITFLHKDEENRDIFGHQIPPCPEMLQRLMNFELPQNGQGKSGLISTVEKVLKYSVNTWDRGFMDKLFASTNAVGVISELVLAVLNTNVHVFKVSPALTIIEKTTAKAFAKLFGYDGPHAGGISTQGGSASNVTSIIVARSHLYPESKKAGNASKRFVLFTSSNGHYSLEKASLMCGLGTDNICSIPTDDHGRMITSELEKQIQSSLAESKTPLYVNATAGTTVLGTYDPFVEISAICKKYNLWMHVDASWGGPVVFSRKYKNKLTGVHLADSLAVNPHKMMGVPVTCSFLLTPDLRNFHKANTLPADYLFHKSNSNEEIWDLADLTLQCGRRADSLKLALSWIYYGSDGFERQVDHAFSIAAQFATLVSENSNLYLVSENPPPCLQICFYYTGTAELKTDKKLNTQITSEIVHALIPRGFLVDYASGKYGSFLRVVVNRETRVNTITDLIRAIEEVGSEVCRDISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0A8</accession>
    <name>A0A0B1P0A8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003702">
        <property type="protein sequence ID" value="KHJ30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0A8"/>
    <dbReference type="HOGENOM" id="CLU_063301_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="42557" checksum="544BF57E5A6B7C29" modified="2015-03-04" version="1">MEVSQKEFQNGMEKKMNSRFEKMEDRLKKNENSMDEIMGQLKNIISALSVLKTNQDKGKGKETVEEVVTAPSQSLFAPSKPSTFFKPISDKFNLAEALNSSTSFKIPKTKRLDFSSLRETTTLPEKRKSQFAKQRLSTGKTTEYQGIHTSKEGAINLYQLPPSNVTQLTQREEKVKKYFPDFFPRSEAENPDGPLRGATKRNRVVFSSELKLKYANSQTLEKLYHMQVAMIQSMLPYTAWPVRVALEMDEDFLAARRAINNHSLDWAGAVDCILTVLFKHNVLGAPLTNLARLTVRTGETSLQFARRLRKHVYSLPNDLILSVQVRDVMRNHIQQSLPKTWTIIQRDIRDMSNDELSDYVVQVSEGVGRWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C5</accession>
    <name>A0A0B1P0C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004474">
        <property type="protein sequence ID" value="KHJ30326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0C5"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="OMA" id="RTTWIIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="27910" checksum="706303BE886A9D07" modified="2015-03-04" version="1">MPVASGYAIIAKDETGRQLLLSLSERLPEDILLEAARDWVSYMLPNIPTHIVTIEGRKPVAESEVITELERVTGLTPKSVRYRGKSKVGALYRTWMVFFDKDSAPKPGFRLFDDSGRATPLKPRQSKLNCKRCLGFHSTGCCSRAPACGRCGSIMHLEEECKALTKCRNCGGPHRSDSRKCLARPTKAGKPTKEQLQVIRIAGQREFDAVNRARAAVDRAKAACISVSSTPASSPEAQAGIIPASVELTVATPQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0C6</accession>
    <name>A0A0B1P0C6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003683">
        <property type="protein sequence ID" value="KHJ30740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0C6"/>
    <dbReference type="HOGENOM" id="CLU_1256868_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="220" mass="24588" checksum="15D32A0A715E897A" modified="2015-03-04" version="1">MKSSSDNGFRIFPHFSRNKAQTSQATDVQGSPASALNAAQNLAQNFAHNAAHNAAPVYHPMPHMSPAHYQQFNQMAHTLHKMEPPRDPPAMTGATCGVATYSRDDIIEARRIGCERMPGNVQDLGSRNSVLYTPADPYKYMHLSPPPYYLYPLGKPIAGRKVKHFGFDRVVLNSQCNVISILTESPGPSEMVGKAMRAVLRRPLKHYDQKKYTYKDCIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0D4</accession>
    <name>A0A0B1P0D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004445">
        <property type="protein sequence ID" value="KHJ30341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0D4"/>
    <dbReference type="HOGENOM" id="CLU_2348245_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="10877" checksum="3D32C85B5F7D8EEF" modified="2015-03-04" version="1">MTSTEITEEIVTKALAELTNIAPVKILTSHSTPSHEYSDQKNLIVLYSKRLSIPRPLQLPGVRFSTELLITRYFLDSITNTFVLDLASAEYAHPQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0D6</accession>
    <name>A0A0B1P0D6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arp8-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003671">
        <property type="protein sequence ID" value="KHJ30750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0D6"/>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="OMA" id="AYKCMWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000201">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="748" mass="84620" checksum="D4C8B6F8A1E4D55F" modified="2015-03-04" version="1">MAGKKSGKALLREEGLQRTDNGMKQSSWPEIQMINQKNYYTSTREYMKRDDQILPYRLQHELNRERMIRIAKDRDRALARTAHGDVPMSMNGDGDIEEDESGQIDGFDASKIIVIHPGSQNLRIGLASDALPKSIPMVVAAKWKHTESEVSEPIPKRRKTDSAPEQQFGEEFSKKYTNMTSALKIEMRANKIKVLPNSKEVVVNFNRRTEPEKIEEHNDALRIEWTEVGKDGQNKLFIGQNALRIPDDSNPPYKLFWPIRHGCFHENDYFTSGHLYDDFSIIIQKSLQDEIGIRRDIEWKQYSCVFVIPDLYDKRYVEQILDMCLKRFGFKQVCFIQESMAASFGSGFTSACIVDIGAQKTSICCVEDGMCIEDSRINLKYGGFDVTETFIKMMLHDHFPYADINLRRRYDFLLAEELKINLCTMNAKNVSQQLFNFHLRIPNEHTYKYNFKACDEVMLAPMGFFDPLIFDNSEKLVGRRKLIDRSYNAYDADIPDDPTSAAQLAILAWIKPSISSTVNGPHSHTNVINNGILDTATPSKEKSNPMNLLSRLDETNINSRVTSAAVSPAPEEAKSHPFTLSNSNIHGESPAPSGNHANNGSHLSSVNSQTAGIILDQATRSPKDLAIERDSVLPIAPLDMAIITSIIHGAKGDDKKARDFFGGIMVIGGGAKTPNLTQYLEARLRTSRPDLGEKLLVGTSPREMDGQVVVWKGASVYARMKTHESWVGQEEYERLGNRVLYHKVLWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0G7</accession>
    <name>A0A0B1P0G7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004325">
        <property type="protein sequence ID" value="KHJ30396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0G7"/>
    <dbReference type="HOGENOM" id="CLU_662567_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="47630" checksum="57B8FE193BFFEED2" modified="2015-03-04" version="1">MALHGDDNTSLDGNEESIMTLEKVQQATKTTILAYMNERTKEYEEYGLKGIELFEYWKADFENFNTAAYKKTTEGTRILRDFLRINGVYIPKNRKSIADNLIASSKTWTPWPVDSYISSDSQSHKSSFVKHQSVSTAQFDKAPPSIENIDLKPEKYDYQPDDNSHSRQTTARGTTEDLRTTQMALQSNFRDDTSFQNKLMTACQAHPACSIACSIPASSSVALINNLRSSISTYLAVENDKNQLQINNKIGNLVDNSDKNEQYFIDRQYYSDLSNRRNKSSNSRQRTPVKRCFICQKSGCWSSRHSAIEREKAKERYNKNFKRVAERQYDQFLVEFEGKNDYDDDNNDTEIKIQTLITDINKFEIPDSEAFITEVGTINLTEASKLITKLSDRSAVHALLRENDDIEDYQIMAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J3</accession>
    <name>A0A0B1P0J3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002264">
        <property type="protein sequence ID" value="KHJ32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P0J3"/>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="OMA" id="TKVEWLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="310"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="907"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1381" mass="158346" checksum="E0F7569FCFB92BE6" modified="2015-03-04" version="1">MVDAIASSQPKRNERSLSLIPIGLREASCDSPTFRALAIHFSDQVAIVEKWLNAYIKYISKLVADLAKIEESFNNVILRSVPPPSITEAIIDHDYTLLALNKYGESSRDWLMQTMSCMKRMESQISEPVKVFINGELRVFKEARRNLDQTQKLFDQMLARYVSQSKTKAPSALREDAFQVYEARKAYLKASFDFCTLIPHFRFTIDKLLIRISFDHWREIKRSSENVVSSSTKFAVKMERIRGWSKEIESSEAVFRRELHFARREIAEIAVETSKPSREIEDYNVSTVAFLASKPPMKTEKKKSEKGSLGAEKQGWLFLRIITGKPTRTSWVRRWFYVKAGIFGWLAQGTYSGAVEESGRIGVLLCNIKPAVQEDRRFCFEIKTKNQSVLLQAETQQILMEWLEVFERAKKTSILGNPNTSSLPDNIDFEISAPPTLSSVIKSIDSHLASTNDDVSGYMSDRFNFPHATGPDASSSSKGTIIDTNLQHRSYILKDEDEQVRDQTHRTVQRLDPVRKPGSALIEQSTSTTTGSLLSSGRSNIPSASNQAGSSLLLNETWKYSLAPKSLVQAPASTSLSKKAISLNSERHTRPTSEFDTGIPSVIVANFWGSSNWAYIDRLEKGRNLPFSNTKDDEHKTYLQDDENSKLQAGIEESLGFTIASDVAREEINHELSSKGNLEAIKLQSYRVPENLPANYPFELMSQDSQFRILFPGAPRSDILLLVFRVIWNHNEKQEFPGRIYVTQRYIYFYSHHHGLVLVTGVNMKDVSDITAAPGRDFDFIFLHMHQDIKDTASRIALKIFLEPFRLLQSRLSYLIHNSQAEVTASLEDILSTLVKMELENNLKTKPSWDSDEDISLLTRGDYGTERSQKLRNSVYGEQWPIAKVNKNEIAKIIFPSHPIDYEPFDKQLKIVERQFNIGSKALFHVIFGDNSHIFQKFYYYRGAENITQGPWQALDYGLIKREFFLEISQSNLFQKHQLNITDLQIIDIKEDHLRYIVSYQNTFWHLPCCLNFKLVFKIVITYVAKSKCKLAFYANVDWSVKPVLFKGIIERQALIDSTVLAKNLIEEITNQVRKLGPHSRTRKSLLIFGQVGQQSLTIKAQPKNFEPRNMIDIKQQTIFLMVSRVAVTYVQVAMNFIITFSSLAIKSIGKFTSANGLILFILFLSLLLNIIFTLRDTSNWWAERKAINFMTRVGVGPNQIISKAIYIKDFDEALNLSLIQKSNPLGGKCYNHFKWITNITDLNLPHHLAGTVFLDVTTQSAARRLLRIRQNLGSYRHSILVASRLINRIEKDIIQAEWENWLLDENIRCERVSLLLREDQMNFLKSKKNEFSADTTNTTNETWQKNKKLNALRNWKDVYCKSCAIEQELLTRRKDHTIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0M1</accession>
    <name>A0A0B1P0M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004398">
        <property type="protein sequence ID" value="KHJ30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0M1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0M1"/>
    <dbReference type="HOGENOM" id="CLU_095059_0_0_1"/>
    <dbReference type="OMA" id="PHNDGEE"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="19270" checksum="77F867EEE6A2D644" modified="2015-03-04" version="1">MHDNQGTHTLLAQVPLLVSPFVSLPVATILPSTYKRLPSTLPASSTGMLQGQSDNKYVISNSGHAVHPDEILSFCEALRNYVQKVKDDADEELKSWEKDIAAKELAERRRIAPGWLDSEARILHPEKPTAGGNLIDSQIGVSNVNASEIQMIQSEAQNREGDELDRAFGVLEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0N8</accession>
    <name>A0A0B1P0N8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gpi anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004363">
        <property type="protein sequence ID" value="KHJ30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0N8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0N8"/>
    <dbReference type="HOGENOM" id="CLU_044725_0_0_1"/>
    <dbReference type="OMA" id="YVCSAYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080415" evidence="1">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="476" mass="51343" checksum="C2AA0FFC77B019E0" modified="2015-03-04" version="1">MFFILAVRILAISMLTLPILCKVSVRSSAEYWHVKRWLNNPSKSHFDDRPENLSNRRRDLSEKVDLMREKHRVGVMKMTADEGQKFFQKYWIYEGDDYLDDSRDANLSKRDEYGNFSSVPMAPFIRPLLPSMFGSPQGSEERPDGVLERRNPAAVLAYLQKRDFQCPKGTADCSAIGHPNSCCPLSDVCFAIEDTGLGPVGCCRRGKKCGGTINNCNNSNTPCPSSLGGGCCLQNYVCGGVGCVINPTMVITTIITVTTMISSSSEIATITTTSIPPIPYTSGFQSCSTDSEANCTDKNTCTSVNNCNSPSIISTSALSIDPGDIPVRPTSLNSFPPSKSQDDQTCPLGFYACEAFYVGGCCRTGRNCDTTSCPPRTSTNLVGNSVTIQVPVGTDASLTRASGSCATGWASCALNEGGGCCPSGWKCGLTNCIDEKAMATTTISKESHSYATKKDIKIMNLVINLLLVVMGIMKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0X4</accession>
    <name>A0A0B1P0X4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003963">
        <property type="protein sequence ID" value="KHJ30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0X4"/>
    <dbReference type="HOGENOM" id="CLU_027162_2_0_1"/>
    <dbReference type="OMA" id="TPNESHQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="530" mass="60561" checksum="D7ADA368D1182175" modified="2015-03-04" version="1">MSYFAIPFRPLSAPASSIASPSLVKTSRKLKRKRIDSSASSNTTLSASSSADSDFDENNINNNITQKPLNVLTNPLNLSEAEIVQYNLAGLDLCEALPSISEWPHRGIPAQKKNPIWSKKDEKRGKNARDERNIDKDQERNKNSNYHKKQVVGEEENRGFIKGHQLRLQHINVLTTILHKCLLAHDVLRASRAWGLLIRMQVSGQGMDLRASGYWSIGAELLIRSLCSKHSGATFNSETETDDGGISSRIRNKSHHPESSRSGWDLIKNLQKTTDYYERLIIEYPFKKQFLSKINALDWWPVMISCEIYGIQHEQKKAIHDLQINTTLEKELSSQDISCDESDREDEIDYEANIFDNDIKSNNERLVKRKQFRKQEHRWQLENKIRLTALNASEKIALRLDERMTTPPYSESLDLLHLRGMLALYIGDLHLPPLPPKYQMEELGKKNDDQFPKSRNIGNGSISQGRLLFRERNIEFQNGLARRSQEINNAKTFFEKLVKLGGDEAAIINLGGENLRIDDEFLPSDILSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0X9</accession>
    <name>A0A0B1P0X9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003433">
        <property type="protein sequence ID" value="KHJ30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0X9"/>
    <dbReference type="HOGENOM" id="CLU_066033_0_0_1"/>
    <dbReference type="OMA" id="KMAIYGA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="270" mass="29402" checksum="207FD4E6C81DEC03" modified="2015-03-04" version="1">MSVKFEKEVIQPAAEAAAAAAAAAAGGGAATVKQGIKMIKEGNKELVHELGVALTGGKRFERSGYLEAYLQQLQTNPLRTKMLTSGTLCALQEILASWIAKDRNRDGLYFTSRVPKMAAYGAIVSAPLGHLLISLLQKVFNKKTTLKAKFLQIIASNLIVAPIQNSVYLISMAIIAGAQTINQVYATWKAGFMPVMKVSWVSSPIALAFAQQFLPEQAWVPFFNIIGFFIGTYVNSVTKKKRLAALRKKHYDEARASRSDDVYGGSHGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y1</accession>
    <name>A0A0B1P0Y1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004151">
        <property type="protein sequence ID" value="KHJ30484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y1"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="201" mass="22206" checksum="46B745E72BFB13FA" modified="2015-03-04" version="1">MEVSSAMLIEEVERITSIRPAHVKLFGRNKAEAPHRTWMAYFSKASRTGFRVFDESGIARPFKKQQPIEFCKRCNGHHPTKNCSRAPSCGNCGSTNHSEELCMAATKCRNCGGPHRSDSRRCLASPTRLGAPTKEQMKTFRQVGEREYQAVLRAKAAEKSANSAENINIDLTCSQDPEVDGNIDNIPASPIENSTGDAIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P132</accession>
    <name>A0A0B1P132_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003857">
        <property type="protein sequence ID" value="KHJ30626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P132"/>
    <dbReference type="STRING" id="52586.A0A0B1P132"/>
    <dbReference type="HOGENOM" id="CLU_000680_30_1_1"/>
    <dbReference type="OMA" id="ENSEFNW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="136"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="402" mass="46218" checksum="A6427C4958C49F5C" modified="2015-03-04" version="1">MITGAYYSSPAKALEVEAAILPCRVRHLKLAYSYPLRILRLQTIHPIQECLFTSQRNESSPILTSKFNLLAHLIDNKTQIVRLGKLLSPLTSNWRLENSEFNWNPPWKSLNIAISIPKLEKQVLRTRHETLFSQIHPSASIIYTDGSRTIGKGSSIGFVIYLPYTREANFYSFNLGDGVGITDAETYCILKSIKTLKNISSSRKCYIFSDSQAALLRIKNANNYFCHQIRRHAHNYQMSMEWCPGHIGIEGNEIADGLARKGAELEIHPQNKYITISVLKENANQEILKAWRKIWNVELLREEEGRIARGLGKFYRVQAKRHNPIFKTKPPNFRNFGRKTQTAYIQAREGIGNMRAYLHKIGKTKSSTCNFCLKGKQTTAHLLLQCDNFKYERKKYFVVSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P144</accession>
    <name>A0A0B1P144_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003352">
        <property type="protein sequence ID" value="KHJ31015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P144"/>
    <dbReference type="STRING" id="52586.A0A0B1P144"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="OMA" id="KKWHNAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="458" mass="50179" checksum="CA54D72E80B0CD6F" modified="2015-03-04" version="1">MICTTAISSIESSLANFKDEIEIEEVATFQAYLQLAIANFAAVDTSPTPPKIPSHSRPSKGSRHGLGNDKIAANEVAIAIPRNITSLESSLRKTQGTSSLPKIPEKVESTWATVARKGKKKARITLSTNASVVSSRKATKSLTSKDKSPTRDSPKIAVTDRRLFVRLPQEHEWRKLSPAGIREVIVNKLAISPSRFGKIKPVNSGFALSPCSTEARETMLNAGNGLFLSGAKLEPATNWTPVIVPTVPENIRKEHGEVEVNKSMLIEEIERVCHTRPAHVKLYGGIKPGAPHRTWMAYFPTAPRTSFRVFDESGIARKFKKPQPLEFCKRCNGHHPTKNCSRTPSCSNCGSTNHTEELCMAATKCRNCGGPHRSDSRRCFAHPTRSGAPTKEQLKTYRQAGEREYHAVLRAKAAEELAASTNNNNIELASNQASEVDNEIDNIPASSVDLPTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M1</accession>
    <name>A0A0B1P1M1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001999">
        <property type="protein sequence ID" value="KHJ32537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1M1"/>
    <dbReference type="HOGENOM" id="CLU_036368_5_1_1"/>
    <dbReference type="OMA" id="EWNVDVI"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="45452" checksum="5B327C5D5505E20E" modified="2015-03-04" version="1">MITSHPDLTIPNQISSNIQNTLQQNENIDSMVCGMRFTNPRTANTVLDKLLSSTTNYSVPDLGSNGLVATVMYRTKSINPLKSSYDPDQLKQSSQQSDPPSDTVCGPGISSTCIESFKCLVSSLMLNDDAPVLTFFQRFLDRPTCPLVVELTSRFFNHKIQNLSKLGTHKLIHEFEDTWNVDIIFQAGTVFRRYPRLVCFDMDSTLIQEELIDLIAESIGVKAEVSTLTEKAMNGELDFLESLKLRVKLLKGIDEDIFTKLQGLITPTKGVKNLIVALKKIGVRTAVFSGGFLPTVSWLAGELGIDYVHANILSISDGRFTGELEGEVVNAERKRTLLYEIAKNESININQTVAVGDGANDLLMLGAAGLGVAWNAKSFVRKQVQAKLNRESLLDLLYLFGFTAEEISSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X6</accession>
    <name>A0A0B1P1X6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002220">
        <property type="protein sequence ID" value="KHJ32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1X6"/>
    <dbReference type="HOGENOM" id="CLU_024412_1_0_1"/>
    <dbReference type="OMA" id="MPWNAQL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF2">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="297" mass="33569" checksum="6236C40BC5BDEE75" modified="2015-03-04" version="1">MPKTKSKGAMIAIEAKTTYIPHIQTHFSKLWPPTSHLCYSESIIAPPPTRHLHCRFGSANLIYEAFYEKDPIDLALDWVDPDGSAPIPVIMPANEKRPGGDWENSVMLPEECLCRRSNLSVTLATPALGNAAKMVFRSGPDRYEVWNRYRALPIISVSPPRRPKLDSSGKKYSFAQERDMMREKIHIALRIAVWYKHTRLCIGTFGLGNGFGNPTEEVAMLWREALMYNPEFIGHFQDIVFAFESPEGSAANEHPSYRAASSSRSRAVNQSRSNCASDLEVFRRIFKPSNIHNAFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P213</accession>
    <name>A0A0B1P213_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003397">
        <property type="protein sequence ID" value="KHJ30966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P213"/>
    <dbReference type="STRING" id="52586.A0A0B1P213"/>
    <dbReference type="HOGENOM" id="CLU_019101_2_3_1"/>
    <dbReference type="OMA" id="NKVYCLV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="417" mass="47240" checksum="DF2C0C33A5F9C552" modified="2015-03-04" version="1">MSDFGESFVHTLALQSWIAYSIGMLFIFLRMYARIRRLGMRGLQADDYLMILVAGLYTTLVVCLNIIAGGGGSNLYLPEDFITFTPEQIQDRIQGSKIVVISEQAMLNVIYTIKTCMLIIYSRLTLGLQIRKMLVYLSVYVAVGWVSTQIAFFTACRPFAGYWAMPPPNPQCTTLEHYAIVQGCFNISSDILMLSIPLPLITKLNVPLKQKSVLLIIFSMGIFVIIAALLTKIFNLSNVWDPSYMLWYVREASVAVYVSNLPLIWPMLREWFPTLKALAPRSRANASQTPKFDTGASTQKCLTEKPERRVSKAISENAIITVIKGQGDQGQYEEASELDTITKQESVEHFDPTLPYHELPASEWDVEDQRIHMTTTVHISEEHLDRPSTERKEPQIDNRRSESPEMASAVGYSWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A5</accession>
    <name>A0A0B1P2A5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-cyclic-nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002865">
        <property type="protein sequence ID" value="KHJ31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2A5"/>
    <dbReference type="HOGENOM" id="CLU_016658_1_0_1"/>
    <dbReference type="OMA" id="ECSYTDA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="53454" checksum="4C39CD06658C49E1" modified="2015-03-04" version="1">MASYEKGFALQVIILGTGGGPFENNTTAFLVRSVAKKWCQGSLLAVDAGVHLAAISKILESSGCFHKNENIENEVELSNISGQPLPVICSGPFEGLELQHRSLKANAGYIAGVLVETYIITHPHLDHISGLVVNSSGLTGIKPKKIAALPPTICALKKHIFNNVIWPNLTNENNGAGLISFKRLAETRSSTVNSNDGKDFTEICEGLQVNAWGVSHGRCSDKHEIGVVATETLSPDELLYQNSSTPGHLREDRTTKNPNTHERIGVYESSAFFIRDIATGTQILIFGDVEPDSISSCPRNKYVWSEAAPKIVAGELRGIFIECSYDDTRAVDILFGHLAPRYLIEEIKVLATEVEIIRNVNQKILKHEDNINSFYDNPRLNATYGYGFADTECAEMVDHTKDEHNNDGELLFPNSKTSESLPNNKLNEAHLPLKGVKIIIIHTKDNLDDSPQVANIIHQQLLEHEKKAQLGCEFIISRSGQSWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2B2</accession>
    <name>A0A0B1P2B2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative checkpoint protein hus1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001811">
        <property type="protein sequence ID" value="KHJ32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2B2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2B2"/>
    <dbReference type="HOGENOM" id="CLU_092550_0_1_1"/>
    <dbReference type="OMA" id="IADKVMH"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="177" mass="20656" checksum="110FD6C3F11FF5CA" modified="2015-03-04" version="1">MERAYMPHPAPEAQGKKYSIMGFFSVFKTLAVTAIISLTFYLILSFVVVPIWKRYRRRYSNYLLLDRVSSNTFSVHQRVQAMIIKYLSPSFWGSQFLRSRHLSNADEGSDFDDDDGEELYEVDNNRREALSLDALRDHSELGSRLSRDLEEGFRDDSDESDSEINILSHCRIQRESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2F0</accession>
    <name>A0A0B1P2F0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative forkhead domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002060">
        <property type="protein sequence ID" value="KHJ32473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2F0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2F0"/>
    <dbReference type="HOGENOM" id="CLU_272641_0_0_1"/>
    <dbReference type="OMA" id="HYKSDKV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="709"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="709"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="886"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="960"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132158" checksum="19482E108FDB10AE" modified="2015-03-04" version="1">MAVSSTAVDEVIADSSAAALNYLPIKDTEFTISNEGSTLPFFVNTESKTQNKLPANLQSDYARTLDLVPKPDFDERSIIKPSRKPDAMVNIPEHEDSSLGTKIMHLPPLPSYISSGNYLTNANMDLQTRFTSPLNSLGFFNSSELSQYNLQTVMNLPMATTDNPLIPTACLKNQPLNLEPARVSAYAKLIFEDGYFYMNTYSVILGRDLKAWHAAIRKEKRRQKQIQEGGDKIGDSDTPIRVKHDGHCYSRSIVSESGGMLRAGNDSDNDGRARLRKLRKMNKASEKSKSTDSSSPSLKKVSAVHPNKVKVYEAQNLQSTILPIDEPVPVDPASFRPSPHDCPLVAIHPPATAPITVYKSISREHVKIAFNSRKCYFEAHVIGRNGCFVQDQWYHTNEVVPLKSGDFLQVGGITVQFMLPNLLDPTTVEYENSSDAPAHENSLDVESDQQHSDRQPEISEEESDSSMDQEALLNGDIDHFCHEKEVKLLTDIDRFKIRKKKKKHGTQQKNSIDQDINIVEDQKAKSKITLCLKLDHKRGPGRPPKNGILSKREQKLLQKKDDQIFNEALNKEDIENIRDKAKKKIKIKGLDLETDSKAKEGLIDGKLENPVESLIETSDPYQPLVSLKNKVGRPRKHPLPDNYNEPPREKRKYTKRKPKEPRELKDGEVNECGSGEEKRVKKEKAPSKPPRSPSPVMNEEDYTPEQLAKPQANYVTLIHEALSNAPTQQLGLPDIYRAIYRKYPYFRFKTQTLGWQSSVRHNLSQHHAFRKVEKDGKGWTWGIVDGISIEKEKKRRATPPPQSYLGLQQTPYQNGLSKIAGHFTYRAPMESSHNQLGHFSNYQLPPRINGQVPSVINPSSNFPPSIPLNLAAPFVPTSYHSPYAPRQTSIDTCTQSADQSNEAQNQTSCNNVSSTIKFQPGINSQREEFKLKEEKTPPQDISAGEMAQAIDHSNLSLGHLSRDQSHQAQGSQSKESPFGSNNTYKQSLPTPSNQQTPQNTTSSQGLNHLSTSVTPSNVQLNEDVIRAAEAFKKNLLESLKSKQSQMIVNSAVNRVLGISSPNDISSNPQEEMIVATLRSLLSKIPGYNNEADIKCSTSYKINTQLPDVIHSSHQSSVQNAQSNNKLIDNDGSIVAVARPPFTSQGLNRPSNAVIHRPSMISATPKTAIHSETPCQDHLHLIDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2F4</accession>
    <name>A0A0B1P2F4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative calcium-binding ef-hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003596">
        <property type="protein sequence ID" value="KHJ30804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2F4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2F4"/>
    <dbReference type="HOGENOM" id="CLU_054966_1_0_1"/>
    <dbReference type="OMA" id="PPLLHSM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="305" mass="32843" checksum="AB2BF114BF349610" modified="2015-03-04" version="1">MAMTIQGQASGHALHVSHTPPRISPFRRPDSIPSPSPLRQSTPSLSANKITSPTSNTDTNTNTTVTPTPPRPSCISSPALEDTKSSERINRNFSISGGENAKPQSQGLSPSQQRIGSAVRSRSTMECNTLSKLQPEQVRELREAFHILDRDSDGHVGREDVTDMFSQLGLSTDPSNISTFFPPSANQTITLPVFLNSLADILSTISPSSELISAFSAFDEDDSGQIDLTEFKDALLQIKPDPGVMPLTKGEIDGLMAGYIGRRAFRKQAGGGLGKRGEVFKYYDFIASISGKSGADGKTEEDKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H8</accession>
    <name>A0A0B1P2H8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative negative regulator of dna transposition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003216">
        <property type="protein sequence ID" value="KHJ31141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2H8"/>
    <dbReference type="HOGENOM" id="CLU_033828_0_0_1"/>
    <dbReference type="OMA" id="AMPEAHR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="6">
        <location>
            <begin position="258"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="48175" checksum="B770D37B10AF8AE9" modified="2015-03-04" version="1">MYRKLDEGTLTTAYKGREDLQDAIRNAATAGPQYVELFNCISTHILSLLPPHSSDQDLSKKRKLEKSLGIETSHNKSSQLQQESENLKEKENILLEIENISFILPQRKKLAFRFTDQYCCALSSQEQVAGSKLAWKDIKYAFLLPIPEKTQAQHGFLLFPCDSCCLLPSRSNPSATASSSQQGPIAFMVPSAGAPKLNSIKGSLSQEISAVSDDYVNLFSWALKKCSNAAGKSIDIICTDEKLFFSSQRQFHRPNEKAVWVKAFRGSTEGYLFFLNCGILWAFRKPVLFLSHSKICAVSFTSVLSRTFNLNIEIFLDDTESQSNEIEFTMLDQEDFENIKRYVNRHGLQDRSMADKRKAKILNVTATTNNDPSTDVNRRPDNNFNNEVAPENQETLDDDDDDEEEDYDPGSEGQSEGSGSSSSSDEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S4</accession>
    <name>A0A0B1P2S4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g3068</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="JNVN01001692">
        <property type="protein sequence ID" value="KHJ32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2S4"/>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="289"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="66389" checksum="8AB1DD6CEF442FEB" modified="2015-03-04" version="1">MPESANPLLLKWVGEWLEEARMCNSKGLQTYKKAYDSLRANPISFSHPSEAKQLTGFGDKLCARLTAKMEAYCRKNNLPLPEQKTDNSRRKRNVNTCSETSEDEIDNSPPKKARKAKIYVPKYRSGAYGLILALATLCESPPAYVTKQESILLAQPHCDSSYTFPSEPGKTYTAWSSMKTLVDKQLVHERKGGTRKYALTDSGWICARSIKNHMDSAKNPEINQDSGLSKDLDSNCGLENGIQLESSMDISSQSNQVSDIIPHGKEINSVSDLPTFTPIVLEPGSFSVEMVLDTREVRCKKDRDYIENELIKKGIEPFKRCMALGDITWVAKVHDPTRLSRLGIEGDEIILDYIVERKRLDDLISSIKDKRFHEQKFRLGRSGIKNVIYLIENITFVPRAHDNMDETILSIIAGTQIVNGYFVKITQKIEDSIEYLANMSKILKEKYAKSHLHIIPTNVLSTTTYLPLLAQRREEEPGVEYHISYLAFGCLMSKSERLVLRDIFIKMLMCIKGITGEKAMEIQKLWKTPKELAQAYRLIDTEKNLSIEEIKKKKRKLVSSKTNHLIGRRKIGPALSAAIYEIWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K8</accession>
    <name>A0A0B1P3K8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001783">
        <property type="protein sequence ID" value="KHJ32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3K8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3K8"/>
    <dbReference type="HOGENOM" id="CLU_029873_1_0_1"/>
    <dbReference type="OMA" id="FYVGHVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="392" mass="44257" checksum="1323E750620EC847" modified="2015-03-04" version="1">MFCFYTRATCLQSPISLCRFYSSKTILEREIVILKSFVNDRAEPILTKPLLPGGFVSYKKLKNIIKHDDIIGKQVRDLVRAKSGVDYRIYRPTIGEYTDNSPRIVTPIYSQDASLIVSLLDLHPTVPGTKTEKLEIFEAGTGHGALTLYLARAIHAANTLPPKIPIESQIESLDDSSVKEKYDAWRAQRRAVIHTLDNQENHSRHAAANIMRFRQGIYFHHIDFHQGSIEEFISGKLAGSSNKPFLEHAILDLPSPQDYMKIVSNAVKDNGLLLIFVPSITQINKASMIARNERLPWALENVLELGGMIGTGGREWDVRPVRPRILQRAEVIEEKILKTDGNDMDKVGQFDHINVDITKKDVKGWELVCRPKVGLRITNGGFVGIWRKISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M3</accession>
    <name>A0A0B1P3M3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g1348</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001537">
        <property type="protein sequence ID" value="KHJ33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3M3"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="45560" checksum="B66F0D1F59AA28E5" modified="2015-03-04" version="1">MADIGIDHRGEERMEFSTSKEVNVIPTFDGMCLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISMLQVIDTAIRETQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHIVSGTPGRVADMIRRRNLRTRQIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTSEDVRILRDIELYYSTQIDEMPMNVADLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3S3</accession>
    <name>A0A0B1P3S3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative casein kinase substrate phosphoprotein pp28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3S3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3S3"/>
    <dbReference type="HOGENOM" id="CLU_068528_0_0_1"/>
    <dbReference type="OMA" id="NQMGLWR"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="28537" checksum="5EB3262E5C1FD4BD" modified="2015-03-04" version="1">MAPGGPPGGGRGRGGKFKKYTRGGGKHFSRNLRPLDEDGNEIKRANDEASSSEEEEEDDDNDESSEEEPSETGIGQPKILSREERRIAAKAKKQAAIAKKNESVVEAGDMPSDSENESDEELMTANPNHSKAARNQTRTTSTDIDNAANKVKDLNINRTAKGRTVGELSRREREAIQAQQARERYQKLHEAGKTDEAKADLARLKLVREKREAEAARKQAEKEEREEAEKAKKDEISAREAKRRAAALGSAKTKGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X1</accession>
    <name>A0A0B1P3X1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002709">
        <property type="protein sequence ID" value="KHJ31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3X1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3X1"/>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="13154" checksum="7186C1E0681F5626" modified="2015-03-04" version="1">MSSIDNLKTFDPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVVDIEMGEVIQLQGDQRKDVQEFLTDKKEGLELDSKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Z8</accession>
    <name>A0A0B1P3Z8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative bax inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002694">
        <property type="protein sequence ID" value="KHJ31656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Z8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Z8"/>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="277" mass="30994" checksum="D1C3CF17E8833C52" modified="2015-03-04" version="1">MAPTTKYSVAPQRDSLDEIYSSQAPPAYTDRPTSATDEAALFQGPRNSENELPDDFKYGGCVAEATVDIRMAFVRKVYAILSVQLIATTVLSSISFFSASFKYWIQSHQWMMWISLFGAIVFMLLTYWKRKSYPSNLIFLSGFTALEAYSVAVITSFYESRIVLQAVALTGAIFIALTIFACQSKYDFTSWIPYLFGGLCGLMVFGLIAAFFPGNTTELIYSGLAALIFSAYILVDTQLIMKHHHVEEEIAAAISLYLDIINLFLAILRILNSQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P493</accession>
    <name>A0A0B1P493_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002626">
        <property type="protein sequence ID" value="KHJ31731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P493"/>
    <dbReference type="STRING" id="52586.A0A0B1P493"/>
    <dbReference type="HOGENOM" id="CLU_048918_1_0_1"/>
    <dbReference type="OMA" id="WMPWGWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="39455" checksum="C3B154E6BF9C4643" modified="2015-03-04" version="1">MFDTFARLLSSIPTFLFPVFASYKALKTSDPSLLTPWLMYWVVLACALFIESWTTFILCWIPFYSWIRLCFLLYLILPQTQGANVLYISHVHPFLQKNEHLIDEFISSFHDRVKAAGIKYLEQIVEFVKQNLLGFPPMENTPPPAPSKFGYTQSLLARFSLPISKTTISSSSLGSATGSVSDFYSLLTSAVNAATHSDSTSRSLAHYLSSSTSSAERLSFISAQRERLAFLLSALDKEAKALETDLTDGSSTPSKVPGMLPENFPGELDETFERMRGSFCGMVKSRSEADFEKIEAESLPEEPESQHNQPGKNTSGGSWVPWNWRGQVDKAQVNTRVKDAELDEGRAKSSGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4L3</accession>
    <name>A0A0B1P4L3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001565">
        <property type="protein sequence ID" value="KHJ33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4L3"/>
    <dbReference type="HOGENOM" id="CLU_405547_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="678" mass="78208" checksum="998B237A5103AC65" modified="2015-03-04" version="1">MPSQSTPEYCEFERELIKIGKKVKELENTNQQLIYDNVSLQAEYKNSLEESSQKISDLEDKASRLERESKSQGLELCRVQEEYNITNDHLEQKEKQFTELASKYRNDKIRHKKEITALSAQVVENETQLSAKIKENHLLRSHNKLLAINGQSRQNKSQVTNQSQICKNDVKERSIDDNQDEPLRDHGNSQNSSPTLASSITSVDSKMSNLPENRQPPLDTYMCKEHIEQWKETVETDTRSVNFNGQILFRIFESGFSRNTSSKLRLNHVDKKDNITPEKLKSYIEFTRSTIHDLICRWIDVEINFLQIILAFILDVFIRSWTVLCHFLAQSLCLMQQIKCHLRLLRDKLLFFLLVPLKKSLFSQRPHESSLSDPFASQESQISKEAIIIDEPTSDQKPSQKSRTSSCSEMNEEEINLLGHNLKKFTLKSNSNKFYEHESIVSPRLLLSPSSGCPIYNTETYDTGSELKPQLLPKTVLPIEEPNSYRTKTSQSLGNPSVSKMQINDFSKNSSEHYIGNSSCILLVLRLLSFLFFAPHRADIIDGGDSKFLESVINSNAKLRPICLTSYRQRIPILNKFIIVNLKSVITNCRKLPVWLTIIAMIVHLCVYIVFFHNLWLTLHQLPLSRSSYYTLVTDSSNLNGWAHQLYFSEQWAYKLERLTYSMGTYLGLQVKNFPMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4N8</accession>
    <name>A0A0B1P4N8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001301">
        <property type="protein sequence ID" value="KHJ33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4N8"/>
    <dbReference type="HOGENOM" id="CLU_1723674_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059355" description="Secreted effector protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17847" checksum="1A91FFFDCE8ECDBA" modified="2015-03-04" version="1">MWLQTRVLAFGFFISMVLGDPTEQTISYPEVRMNVQCGDRYYSSVALAKTAAPACSRYEKQRNCRNQKSCSFGFLRPTKVSMYKGPYFPQYSQNEENDDRLLLWPLPRKRWLEKDIHFAVIQYDVRSKKCSVVGAIKDTDVRNHIECEKTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P3</accession>
    <name>A0A0B1P4P3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001297">
        <property type="protein sequence ID" value="KHJ33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P3"/>
    <dbReference type="HOGENOM" id="CLU_1379044_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="198" mass="23427" checksum="8856FD695B0F861E" modified="2015-03-04" version="1">MASDDKVVCNLVPKSAQISNTVANTLTGQVTPDLSKERENQALISSNVSSMSKETLQKTAQMSLEKINLNHDVRKRKRDCDKVFEAIENVNSQLAEFQNNISRLIQDATRSILEIKERELKIETDYRRQALDLQKQAVEIARLDLEERCLDRQERHRREDRLQQEKFEERRKRTRDRERERDEQRQEHRRALSAVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U2</accession>
    <name>A0A0B1P4U2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001278">
        <property type="protein sequence ID" value="KHJ33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4U2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4U2"/>
    <dbReference type="HOGENOM" id="CLU_1074404_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="259" mass="30680" checksum="65DEC923D9B7472D" modified="2015-03-04" version="1">MKSRLHQKNLPPPPQNWHQLQHHPHWNGFTAAARAEFSSLELQGTFRDINQSENKTRPIPIKRVFTYKFDDDFFRKYKARLVIRGDLQIPTEKDTYAAKLAVRLYRVALAIASYFNLEFDDEVLIHYPEGFKKPGRLLRVLKALKALYGLSVSPRLWYNYLSKTLEKLGLKYVPGSGYIFTNEKLIDYFYVDDIVLFYHMSHREVFQELKNTLLEVYTIRYLGELKWFLGLRIIRDRDLRKCGLFKTNILKKRPGNSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V8</accession>
    <name>A0A0B1P4V8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001534">
        <property type="protein sequence ID" value="KHJ33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4V8"/>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1679"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1805"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1695"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1826"/>
            <end position="1842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1856" mass="211678" checksum="1C6602521212A964" modified="2015-03-04" version="1">MRWQASFTALNIIPDDHAEDEIDNTKEIQIEDALKLYQVALKLHSQGPDQYENAAKAYQELLKSEVFRYPESESEFQRVYNHPEFEYVDAAIALELAAAGANGAPCNLPQILYLSYKNHGQFILDCVKSLLQHAKISSHELGYQGIAAVENFSLAIVSDESDTDLWRRIARVSAMLGSKRISRYCLEAALEVDDDPTVAEVEPASLEEGFAGEQLKEHLEILYDDVALLHPIMIPYLEKSMPKFLSKYKDLYPYLPDETRSFRYGERELKSTTLQLMIEVESRTWSGVGDRFCELWLSSYELGHPGAAVGIQITHQLKDVQEIETTTSQTGVVDQYSKDVEMTDAPTLDSSEIASVSFVGSRFTGESINLLNTATNSRAADETLPSVVILPTRKRSQSTAGFCDVRDDDIGAQKRSKRIRNRDTLADENVDSATQYAEQLEKFAQSDEVVFDFVGSILKKLDIHDLGTIKELQEALALKKPIDNEEIIANTALRDLRDILKTWDDVKASTFVDGNTADILGSSVGGENAGLTAFLNQHEIESTKLSNFPILNETEGLDEFIGLLNSRWTPLQDAIFEWILVILPTYITNIWSERLKLSVVRLISYVDADLFSRFQYDAKQLRSNKRNMIHLVEMTQSVFEIHLDIYAQIIGPNSTVSYNTRNLSHDRLRRWAGLSADIVGTYISDSRSDLSLRYLWTFALYATLTDDVTREHKISCWSDLESHIEEAGDHIIELPNNAAMPEISASAAEREASKLKTMDFFFNLFQADRSDPIVIIETLEPVLDPDCAIQPHIETEDTLASTTGSPASLKDMWKFLKSGSTPLRLFLWQRLREAYLSIGYSTQVFSCHLRSIEVIVEDLRSSNYTESAEDSRQHKLLNWLKALDDLLVKSLTMALNEYETCFEIIDERQLKSICATIAQLSRILHAAAIFDDEIRVKMVQLPATAIFSERGSFNGFINKLREMQVRTWALQYTLIKEAMSQFKELFPMPNILMMDYLAKIHNALGIRKMCKISNKIFLKMMKVELIRMKQIDRWEDYLGQVLYDLYGIKLGIGTRPLEEHGCPPEQLDKKTALSIADQVIAIANSLSMKDLLKHDLRVTIERMQAVAGLVKPSSQMQHNLRNYNMYLKTSISPLELHQAWKGQLQVNLLPVTAMENTLSRKGWYFLLGMISLTKYRSTKRLSPGPQSDDIRVASNYMRLHLQCNSDHWETWYHLALCFDYELEEEVLWSTDKINHHRTELVKIQRSAIHCYAMALSTAHQVADVSLKTGKKLSEMYQDFGMRLYASSRDPFSMEVFYLDDFERHMSGVSGLYKRALHAEMTKYRVWKFAAKLFRASLRERPDNWINHYMLAKCLWKMYYHLTKEEDPKVKENNPPTVKDILRACLDAIKTVPKPSKSSVEPIIEPHYKIVSIVHKLVKMEAITAQAGADLIQQQPFAARKGQPVIITNYEEEWSSYIIEQVRQLRKEDKQHWQHRMISRVASLLYENDEPMPSQNKAVSAKNEFRESMFTKTMHIQVWKPDHERPGRHCVFMERYTRRMVRLLEITNDKSNLEALVKRIRKKGNEFYRFTQVWTEACIAYLRIIRQAGCIPSSVDDIFKSTPADEFEIMSHQLTVWISDPLMYHPALEALRDTSELKKINANLMKPAPIDDLINDAWAVLYTDVAKKLLIPDLLGGKIDTSEDKNSPHKRPGGVSNSSTNATINSSKTQNVVGVATVPTKERPKKIGVSRREVLRRAESAVNRTTDQQRSSNIGKPSIMNMLFGSNLGLETQKDKLEPIKTDKIQKSSEIRVETVEGSAGISIENLIQAEGEEECDSDRESLYDSSGDESDLSDVPDMDDIDSASIFPNLLRKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Y4</accession>
    <name>A0A0B1P4Y4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002405">
        <property type="protein sequence ID" value="KHJ32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Y4"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Y4"/>
    <dbReference type="HOGENOM" id="CLU_006646_0_0_1"/>
    <dbReference type="OMA" id="PHNIRYS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1209" mass="135196" checksum="CB3AC1474CB2545E" modified="2015-03-04" version="1">MAESPKYCGRNQPKSYYPQYQNQFSTINHAVYPYNSVPPSFSPSNLSYDSQIFPLISRWNQDTNLPLLSNPQNEQMHGSCQVHDHQDNTQLYPSHSIPNYFVNIPNRNAINSVEIIDSGLQRNFSNIHVPKNQSEISEVNNHVQNIKANIEKKESIQNQDSISPHTMQRQPSDSYSPCVTPLASELPPEKKAPIISTPLPEKNVNNILNNTSLQGLSQNFPRNETKIAPNMKNLSECRREAQKVILNLLPYGVRYETYIDEGFRKDIVDKLFQDLSIDHGDLSNIAHHYNNHLTKENPNIQSENGSNHVSSLPNQLEPITKDKSNLSASAAPTKRSDVIEKEKQLQSDMAERHKTLQTKMDALRKSRELRASVKTGIKSKVDQNPENKPPTNHDISSINEKDTGTSSNSTTRSNFNVTSEPPVAKSKSSVNNFISVTTQNTDSKTPELVLSTSMANQVSTKTPAIPGLFLVPNLSNNAIIETTKTTASPVTKTILATTASPKSSAKPTTTVNSVTTINSGTEVNPTTIEMSTDLDNIARLRKRPVASDFDDQSLTKVPFKRPFGHNRGEQRIVINVSDDESEDEDVTTELEFQLDQESSTLTSIKTSNTSQNMQLGSNLSRPKNFTSPTNTSSTPLSVNTNQSLLTPSILKQKQREIQLMKERIAAAEAQLKAKSTTGSIETRQQSESTVPEIKDNLNKDEISSTEFETSLLNMERVHRDFDQEQIKFTQALDITVEDSALKTDSLQEKILRRQKIATKLPIIESEVEKGRSKLEQLKTEIAEVEAGLEKNLEERNRMTIEMKLLYEEQEYLSASDVVPSVTSENLCNLNPKKPHSEQGLRQQSLPKENVENNLNIFSTRNHSLPPGNTSFASTVLQKFQGEENTITDTFDTLNVTDDSQDKENAKIFSIATIKHDRMTHVENEIQKVDTNQADSIGNSISSEAINKEQYNIFNQCSSNASKSTFQEGEQSIGYILEHNRTAASESESDNYEPPDATVMDRISPLISPRFSPAPPESVELVKNNQTQISDKNQLCQITEPAKINKLLSQNSGISPIMKDEPILTFNSSNRYTPYQSPLKLFKAYRYHPNFKNEVAGGLRSKTYSHNIDANKEFCRFEMAGGICNDSACTLQHFKAITLPDDGIMAALGCPDEFTGESREKFVSGLREVLLGLRLRKVNDFDIIASEIIAHRARFLSDQSKILSLEGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P526</accession>
    <name>A0A0B1P526_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1P526"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:cellular respiration"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:glycine catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042743">
        <property type="term" value="P:hydrogen peroxide metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006550">
        <property type="term" value="P:L-isoleucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="46"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="391"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="84"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="510" mass="54352" checksum="4C8EC31C9595C68F" modified="2015-03-04" version="1">MLQGISTPRLAARLALRTPSSSKLIISQLNLCRLKRRGYATEAEEKDLVIIGGGVAGYVAAIKAGQEGLKVTCIEKRGTLGGTCLNVGCIPSKALLNNSHLYHQILHDTKARGIEVSNVKLNLAQMMKSKDTAVAGLTKGVEFLFKKNNVEYIKGTAAFAGEHEVKVNLVDGGEQTIIGKNIIIATGSEATPFPGLEIDEKRIITSTGAISLEKVPESMIVIGGGIIGLEMGSVWSRLGAKVTVVEYLGQIGGPGMDAEISKSAQRIFKKQGIEFKLNTKVLGGETGHDKISLNVESAKGGNKETLDAEVVLVAIGRRPYTAGLGLENIGLEADEKGRLVIDSEYRTKIPHIRVVGDCTFGPMLAHKAEEEAVAVVEYITKGHGHVNYGAIPSVMYTHPEVAWVGQNEEEVKASGVKYKIGTFPFSANSRAKTNLDSEGLVKMIADAETDRILGIHIIGPNAGEMIAEGTLALEYGASSEDIGRTSHAHPTLAEAFKEAAMATYGKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P538</accession>
    <name>A0A0B1P538_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002372">
        <property type="protein sequence ID" value="KHJ32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1P538"/>
    <dbReference type="HOGENOM" id="CLU_012648_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="661" mass="73003" checksum="24D63C0957AAE51B" modified="2015-03-04" version="1">MENSVLEENQTNGLAEQSLTHALEALLGGLRPIPPLSTELSKNEDSDLSNLLENKSILSRDSSQLIEIQNENENLGPSAIPYDISKTTFSYIGAENSRNSPIYDEKQISNPDHTISDIGYVDNRTNSVLAQESQKDVTSSSICERKIDHHITEKSEQTTDAMTKLVAKNPVIPGLFLCDINNTNKKPTNLETIPPDFSTSQNFKSNSGISNDGIQEPATETTVITESPTDVEDSNVVVSEEANMEWEADSSPIEDSSDEQDSSENNTSSDDSEAGEDSFKFLSPEEQARILILGDGGSDDEGGDKSKGPEGQLRTKNEIVNEVILKPNVTITQDMPITELGAVEQVVDNILLIKAKISGEYKVLESGSVLCLSDRKVFGAVAETIGRVQQPYYSVLFTDATEIQAEGLSIGTIVYYSEIHSTFVFTKSLKAFKGSDASNINDEEVGEDEVEFSDDEAEAEHRRKIKLKRQEKRGVKIGSNGCLKRGRQSLQKLKEHPDDTSAINYDENDDEPYKTLTRPTGYVGSITRNEGSLEQTNPSEKDKKNNGEKNRSRGRNNRHRSSVNSGRGRGFQNRRGNRASAPRNLPHNPGNDSSIANTTHPNSVPGLYNNLLLPNTPINPYTSAQNSLNMQQFQEYDPRQVQAQQWPNPFLLFYGMNPFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5A8</accession>
    <name>A0A0B1P5A8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001187">
        <property type="protein sequence ID" value="KHJ33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5A8"/>
    <dbReference type="STRING" id="52586.A0A0B1P5A8"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_3_1"/>
    <dbReference type="OMA" id="RKEPFQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="236"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="47686" checksum="DBBBA2DBA35EEBAB" modified="2015-03-04" version="1">MSLAAKRIHVLGLGNLGCFFAHCLRQADRITPITLLFHRESLYKDWDNAFQRISITTTEDFINDISYQNNNRASLLSSTSDPTTSISSAFDIESTFSTNSTISTHSSEGANNYRSNDESPIYNLVLATKSFQTLDALSSIKHRLTDQSSILFVQNGLGIIPEINQVLFPDILTRPSYLVSLVSHGLYSSGPFKSILAGPGRVIFGHISKPSPMSSALVDVILDTLMLNASYFDHLDIRNFQMEKLVVNAIMNPLSALFRCENGKLFWVGTNRILVRSLMKRLISEINQVFVRLDGLNGPLDPDRFAVGNMESMVTGIARKTRNNLSSMLQDVLHHRDTEIDYISGWIVSEGEKKGIDVRCNKKLIELVKKREKLTEDLIELHFPGTITRKDMNAWTQALEGLRLNGIKDTKKPIFNQTGLCLEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5K7</accession>
    <name>A0A0B1P5K7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative electron transfer flavoprotein alpha-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5K7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5K7"/>
    <dbReference type="HOGENOM" id="CLU_026457_5_0_1"/>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="38134" checksum="F9D207B84035336C" modified="2015-03-04" version="1">MIKQIHAINIIIEQLFFNTLLPLNDNMAPESNLPIMQSENFSVYQLNSEQVLKASTALIKHIESTTISKLKARKVKLLDEDPLESQPIWLQLTTKSHIAPEKRLKPIKVPLPHPLNTDPTTTICLFTVDPQRATKDLIASPAFPAALSSRITRIIGLSKLKSKWSQYEAQRKLYREHDIFVADDRIIKSLPAILGKTFYKSTSKRPIPINIQHSVPKKGGKRIKKVKGDPPRPLTDATSLAKTIEEAIESAVIYLSTSTNIAVRIGYASWSPTKLQENAEALSKFLIERIVSKKWKGLRSLHIKGAETTSLPIWQAEEIWIDEKDIIDDDQTQGKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5S7</accession>
    <name>A0A0B1P5S7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative intracellular protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001326">
        <property type="protein sequence ID" value="KHJ33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5S7"/>
    <dbReference type="STRING" id="52586.A0A0B1P5S7"/>
    <dbReference type="HOGENOM" id="CLU_006318_4_0_1"/>
    <dbReference type="OMA" id="WLWEDPK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="338"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="766"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="666"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="896" mass="101234" checksum="CC79CF459A5DB8D2" modified="2015-03-04" version="1">MFAIATPTKQKAEDTIVTLASRLSSATLLEDRRAAVLGLKSFSSSYPATVSSNALRGLIGCLDRDRQDVETSLATLQTLLQLFNPNDNSLEASEEIALWIADEFTQQQDNITLLIDFLDVQDFYSKLCSLKLLAAILSSRTERTKELICSAPLGISKLVATLDDKKEAIRNEGLSLLIYLTPNSSELQKRIAFEDAFDRIFNIINIEGSLIHGDGLVEDCMILLANLLRLNESNQTFFRETGFVSKIAWLLADAVKGHDEETELSNWARTQRDRNLFALLAVVRLFLVTGCTILQVNQVSFWQSGVPSQALKLAFSPSVEIQIKSEALITCADIIRNNSKLQEEFGQLQVTSLPLDSHTEGSLRYVIDGLLEITLNNPTLKDFDIRIAASNCITAYLYKHSIIRQHFLLRAIEGYMKGEDVTPNFLTILLQPSNDQAIVDPYRIWFAAVIFFHLIFDDSNVKSLVINLKEGDAASGEEEITCLQSLTGRLLMALKDGADERILTGYLMLLCGWLFEDSDSVNDFLGEASHLQFLIQVVLNKAIDSLIVQGLCALLLGILYEFSTKDSPIPRSTIHQILCSQLGKDKYIDRLLRLRSNSFLRDFEILPQKLNLAPIGGLPEVFFEKLFVEFIKDNFSRLLRALDRDPDYEFTIFTNGAQKGISREMVDSLRAQLEEKQQLLERYEEDIKILTSKYDQEQSYHQNTKVTAEEELNKIKQANKLLKENESKLAIKLSQEHDQVVQEYKRQLEHLATAAKKDVEQTRESNKTEICSLQKSINLLETELQLSQTNAKHLQNAYDLLRISDKNNLELIDTLKKKVQDLEIKYNAAVKKSSNLEISLADKEKEKSLTQAELEDLLIVFSDVEEKVKKYKVKLKALGETVSDAEDEDVDAEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5V2</accession>
    <name>A0A0B1P5V2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001068">
        <property type="protein sequence ID" value="KHJ34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5V2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5V2"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="268" mass="30652" checksum="A7BD460CCDC67146" modified="2015-03-04" version="1">MKTPRSRKEKTSCPKDTRFFSRLTSNHEWRKLSPAGIREIVVKKLSILPPSISMIKPVRSGFAPSPRNDETRQELLKGAILLSPFDAKLEAESNWTPIMVLTVPKSIQTLEGKLEVTKEMLSNEIKRVSLVRPASLRLFGRKSPEDPHRTWMAYFSEASRPGFRVFDESGIVIKFKKRQTLDFCNRYSRKCLARLARAGKPTKEQLKTFRQAGDREYQAIIRARIAEERATTIQRDMKIIADSQSENIITDNSLASSVESSTDNVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5X0</accession>
    <name>A0A0B1P5X0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g2364</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="JNVN01001292">
        <property type="protein sequence ID" value="KHJ33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5X0"/>
    <dbReference type="STRING" id="52586.A0A0B1P5X0"/>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="OMA" id="IYTRCYS"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="166"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="376" mass="41106" checksum="C1D1B3BAB42FF857" modified="2015-03-04" version="1">MAQTVISSSSFRQIYIAVIGTGGVGSRFLAQLEYISKQRCEHPSSPKLSLVLVSRSSKILYDEEYNKLPFENIYVRLENSQQKILKLPEIVDYLSAAPSKTILVDNTSSQEVADFYPRFLEKGISIVTPNKKAFSSSIELWKDIFSAASNSGAQVYHESSVGAGLPILSTLNDLIETGDEIIKIEGVFSGTLSFLFNSFAPVNGNGGKWSTEVTNAKNLGYTEPDPRDDLNGLDVARKLTILARLAGLTVESPTSFPVQSLIPKELENVVDGNEFLQKLPKFDAQMEQIKVAAENEGKVVRFVGSISFATKEIKVGLHNFDRSNPIAMLKGSDNIISFYTKRYRDSPLIIQGAGAGGDVTAMGVTGDLIKVIKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P660</accession>
    <name>A0A0B1P660_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sterol regulatory element binding protein sre1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002091">
        <property type="protein sequence ID" value="KHJ32426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P660"/>
    <dbReference type="STRING" id="52586.A0A0B1P660"/>
    <dbReference type="HOGENOM" id="CLU_008057_1_0_1"/>
    <dbReference type="OMA" id="RVKTWDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="903" mass="101141" checksum="75C3085C31694303" modified="2015-03-04" version="1">MTVPHEMDLPSSLPYRDSLNPAAALSSNFSFHNFDGLKNTTASHSQTTLPLDDSSFYASTWEGTAQNETLYATPINWESSEPMLDYQPPSNLFTPNSFQNVKWEGLQSDGKSSNVQLYSHRSSQSLSSSKSRSVSSPENNDRNRKRKSIAELEDDEDDDLNPLVKKTAHNMIEKRYRTNLNDKIAALRDAVPSLRITSKSARGEDTMDDREELQGLKPAHKLNKATVLSKATEYIYHLENRNKILQQEILDHKSRLATYEALLRSNSLDCNTLQSISNPFQFSFDYPSPSTPHPVTQQTVVQESDNFQRQVNQPIYHNLPQEPYSQYQQQQPLGSNQWNGHSYMGKVMVGTMAALMILEGFSEEEQSSESPVGRGLFAVPMHILSFIKFLFKMPLEINIFGYQSSSYEVIWFFKFILIFSSVLYVILPQMFTSRSISNRGKIQNTLLSAAPSLASPIQVRRQAWLTAIQTVWVPRHNFLLEAAALCLKIAKISTRNICGSQAYTYLTGITEQQEAARIKAWNIALDAQLAGGDIEINKSRLTLTLLASATLPDTPARLMLNALHIRVLLWEIANFSFYGYCPFRGLASGLVKWKWKKAILQRELGIYSKDEADDLPDNLIVLLQQDSDYVFNDSIAQRAYNLAWNLPTTRNIFVENDCMDIVVDDFAIRGPLDAVAAWFSSFVLQKAISKSLQIKENNSVEEQSVAESIDLAIKIAPIGSTIHIRSLLARSILVKEKRGASIAETMQALGPLNKQISQNYTLNLINTGASVANIPDIELSLRCATAIAHIEHSTSLAYPEKAIKIIQSISPRKLSLLSFVATFKLMEKMNKHEIIATSCVNSLEIFAGVLRIWMGGKDANEVGLPIEVKKETIECCLAISKRIIGMQDAGYASMSESSDVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M5</accession>
    <name>A0A0B1P6M5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative u1 small nuclear ribonucleo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6M5"/>
    <dbReference type="HOGENOM" id="CLU_079697_2_0_1"/>
    <dbReference type="OMA" id="QMRPPLM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-C C2H2-type zinc finger" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="174" mass="17726" checksum="174E9E3B0134486D" modified="2015-03-04" version="1">MSVRKAHNSGRNHLRNVVDYYQQIGHEKAQSVIDSITNSYAAEGQSASNPMFGPNPGGHPPPPFGIPGGLPPPPFGMPGMVMPGMPIPPPGAIIPPGGRGLPLPPLPGMPFPPPGGLPPNFQFPPPNGLPHLPVAFPGGVPPPNFPPIPLPVQQPSQTPLPGGVSGGSPGGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6N9</accession>
    <name>A0A0B1P6N9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcription initiation factor iif subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000928">
        <property type="protein sequence ID" value="KHJ34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6N9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6N9"/>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="OMA" id="PGMGFYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="544" mass="58606" checksum="481589668FB5CAD5" modified="2015-03-04" version="1">MNAGGLTQMASFNNFSSSTEFGVPTSGFTSRRGSTIKSLSFDKSKISGLPENSTPTPRTSRSHLLAGLRTAPKNSNGSGPLTAPPYLQNDSNNNLRYATNNMNHYDPSTYSRVDQQNICGSQFYTMPEDILAPPEIHIDEASCEQMDANYYAQLIATNRYLAEQQQRLQQQLRNVQVAAQQFQGMNLGLQQCSTPPITPQSLYQQQLKYNLQTIANPFGNMLPIYPSYNIINGNPAHLQSNQQAGQLENLQSAQNFANHTSAQKTPAHTHVRNFTLLPESNTQTLGASSPGKSNSPTYDHTPLPPPSAGAFRRGHRKAPSSLAVYSENGSYLDTSKTSTTPKSSAISYMSSGFGPGQARIGEHPIRQPRGPPSIEVLLAKPNTTYEGAKNFATRTRRSAVGNLVRAGIERRRVPGSTGSGSISPASDAGDVTFSVTDNDSDSGRSGGGSLSSRPTLGSPRTSIHGAIGSNRPSSRQNSRFMERKSIASLNSSYTSTSVSGDECSSLGGNFAVVVKNGRKGYSDENEKKAPMLVLTPAEKHKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6U2</accession>
    <name>A0A0B1P6U2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001119">
        <property type="protein sequence ID" value="KHJ33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6U2"/>
    <dbReference type="HOGENOM" id="CLU_909717_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="306" mass="35526" checksum="0AAABC82E3018EDB" modified="2015-03-04" version="1">MTKQTSDLAKFYFNDQKKYGGEDLYDFLDQKVIIFHDYCEKVGLPRSQHHWAFSIMLKGRAAGYYYDEIVGNASSIKQMIEMIKLHFETGERTQALLKVWRETTLHKIFTDDPDKNRLEWRGRGRGKEGRAYGSDFQQRQKKCYVGGKRGCWSTEYPQEVRRMAYSRFCTQYTHSSEPNLANYEGIQGIEDLVEDKDKDVDETQYILDNMHIEDEFKEDDFETEAYFSDDLGRLNGIQILTHLQNQSVWHLVRISDPFEEASIQETQANDILSFDGRYNEGVFQGIMPDTGVAGVSTVGKPQFCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P720</accession>
    <name>A0A0B1P720_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000846">
        <property type="protein sequence ID" value="KHJ34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P720"/>
    <dbReference type="STRING" id="52586.A0A0B1P720"/>
    <dbReference type="HOGENOM" id="CLU_007183_1_0_1"/>
    <dbReference type="OMA" id="NTWHEAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="639"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="92066" checksum="BB01350C5BE0CEDD" modified="2015-03-04" version="1">MSPTKVNRPMDEVIKEKDVDQKLQLYGVASALQVGKVPSNEQIDIALNSFLASTALSNPPPGLSIEGQGLIADFREVVEQAKILLLSKNQGDVIQDFIWQTQKIQKRDLNLPDVPVEAESAQQHSQQALNGLRTLGKLIISNGQFRKLLKDASVLLREVVGETAQKAVEYVSPSQDELSQIDNPAAKNTWHEVTDISSHSLKDRVKSYMPNLQNKERLQESSMKGHAFHSDESRNPYQSAIRSTPEHKMGPQSSVSQQSFNQDASLKSKDRISGNFSEGSIKQGSEYRERAIDYLSGKFSEDRREKTKYRLQNLVLECQKHHDYQEAITTLLNLAETYVSYANKVSQEGTASIKNIQDDDAINKVEADFKILIERFANGTSTKALFTILDAVYSDASQDLELKNWLKQLNSYIRKCLQNEGFIMKDDSVNEWNEIFDTGAFLLRDRYRSRVDQFLSEIKFLAEQFDHDPLNKRFAQATEKLFADLGLDENGNPSFKPQLLKDLTEIIIPTIFENIRYIPIPRIEYSDEVVDLVVENLIIESDNFFPNIFEFTNDNYIRLGRKSISNKSMHSASLHIAGIQMDIKDVAFFLKKKKGFPSIHDTGVVDIFLGGSGFSFTIKMSTSDSKDRENFFKVDKVDVDIKNFKIKIKKSQHKLLLVISKPILLKVIRPALQKALEFKILENARRLDSLLFKIKLDVDRALQEAKNHPEKSKNIYQNYLSAFQKHFFQKKEKAEAATSGILVNVAITKHDSIFPNIHLAEGISSIATKYKELALQGEEWQSAIFNLGTAPPSKNIPIAPEIDYKKHPTSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P740</accession>
    <name>A0A0B1P740_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gdsl lipase acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001068">
        <property type="protein sequence ID" value="KHJ34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P740"/>
    <dbReference type="SMR" id="A0A0B1P740"/>
    <dbReference type="STRING" id="52586.A0A0B1P740"/>
    <dbReference type="HOGENOM" id="CLU_015101_1_0_1"/>
    <dbReference type="OMA" id="KYFVIMN"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058949" evidence="2">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="39812" checksum="A6414E0A6C2BA62D" modified="2015-03-04" version="1">MWLQLYTIIQVLALCRATIIPEPSFKTGWIPSFANLVAFGDSYTDESRLAYFTTHNGEAPPVGYLPPSSTSTAGGGVTWARFVSINTGAKLYNYAVSGAVCDNKIIYRYVSALNGPFPDVVYEVNAFVADSKYIDPSTKVPFYSNRYENNTVYSIWIGTNDLGVSGFITDSNLGGSTLSTFTDCIFDKFDQIYAIGGRYFVLMNLAPLQLSPLYGIPGAGGLSKSSYWADKPGNSTEVSSKMKEYTKTVNALFEYRVPYENIIAKRYPGASFAIFDTNALITDIYNNPDNYLTPPANATDQYFKCEPVFGGACTKKPEGLDHYLWFDELHPSEKTDEIIAGEFSKVVKGTSKYARYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B7</accession>
    <name>A0A0B1P7B7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001555">
        <property type="protein sequence ID" value="KHJ33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B7"/>
    <dbReference type="HOGENOM" id="CLU_041473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="427" mass="48721" checksum="BF17104A080B7D37" modified="2015-03-04" version="1">MASTTPLFKTCSRCRKNLSPSCFLRNEECNLYYKTCIECRSKKNLRRQNLRRQQSVPPLQLENEENISANEDTFNLNNEGPHNNLISNDLISGYENDVSIPNIISVPQIENVTSNNSNLVHCKGCKKNCAPDLFTNLTRGKTFKQCGNCRQRKNSRRHPESLLAQPNENRLYSTILPVNAQTNITLNEVSETTTILCRKCKRNCVPESFANATSNLPHATCFNCRTRDHARRFPTVFQPIQNQSQYDYIEDVGDANDEDVNQLAANIGMFEIVEEEEFNGPVPEEAPLGDDPIFMLSQLQSREFRNHDEIQRRLQADEEENMINNPDEVVQVEDDIIVSEIDPNIDPFLEELPPAEIYNDDLLENVVLNDPFVEENSHAQNNVVQSQSRFQIDPFLESNPPPQAEVLITIDNNQQPAEIGEVIEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7F8</accession>
    <name>A0A0B1P7F8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000997">
        <property type="protein sequence ID" value="KHJ34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7F8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7F8"/>
    <dbReference type="HOGENOM" id="CLU_1116452_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="249" mass="27564" checksum="BEBD908810FC976A" modified="2015-03-04" version="1">MQGSRNRRWAIGVGGSGVESSQLGGKFNNLTYVTNQNQSDMSGTAAPISLASFGEALKSLTIESLYSKVNELENSIAHLKDSNQQLKSFTQGMISKTNTETNIDHQLILEHDQECIDAIQENVVVITRFQDRIKLLVAEIEARGLGLQITTSSTTQKEKKTSLTSLANNNLRDVSISHLEDGVMVKSYQNEVAEKIPEFPSNHHDIDAMELMTDELIKIRTQGEFKISQEISSNKVMVGNTESEEGVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7K6</accession>
    <name>A0A0B1P7K6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative air1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001903">
        <property type="protein sequence ID" value="KHJ32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7K6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7K6"/>
    <dbReference type="HOGENOM" id="CLU_046750_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="38249" checksum="739845781DE1CF0B" modified="2015-03-04" version="1">MAGVEAGATQAIGKNAVQTSEKGEFQSSQVVIEKIGDVLKKMKGCLNKIGLKGMIMMVEEVDEAIEVLNNKRFIWLHATQNNSLEHRMLALEEAAKKNLVEKCGQMSSKGVVGKSYASVVALPAAKAAVRIRVPGAEELQPAELLSIAKQKIKGAYAIRQMRSHDTEVFVQSSNHRDAVLSMEQPKEFKILRKDFPVEIAGVPLSTKIASEKNADNSALISILSNVSKMKIPGLQTNRIRWLQGGKEHEKARKKGHTRGSRAVCKTLKVYKEGVERARFENQIKTVEIRSEKIPATESKYVPVNTSDEEGFTIVTRKSSETKRGPGRPRKDALAPMKSQIIATSHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M5</accession>
    <name>A0A0B1P7M5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001898">
        <property type="protein sequence ID" value="KHJ32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7M5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7M5"/>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OMA" id="EKGFNSY"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="34008" checksum="EBCCFB17AF1D9B25" modified="2015-03-04" version="1">MATEIPIPVSADGSVNNGINKGTSKPVGQKNFGVKTGLARMLKGGVIMDVVNAKQARIAEEAGACAVMALERVPADIRVEGGVSRMSDPKMIKEIMSSVTIPVMAKARIGHFVECQILEAIGVDYIDESEVLTPADNLHHVEKHDYSVPFVCGCRDLGEALRRISEGAAMIRTKGEAGTGDIVEAVRHMRTVNAEIGRASRMTDAELRVMAKEIQAPYELLRETAKLGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDALKRAKAIVQAVTHYIDPKVLANVSEDLGEAMVGLNVSTMNMSHKLQTRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X3</accession>
    <name>A0A0B1P7X3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01001413">
        <property type="protein sequence ID" value="KHJ33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7X3"/>
    <dbReference type="SMR" id="A0A0B1P7X3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7X3"/>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="329" mass="34586" checksum="7F03C267564F1134" modified="2015-03-04" version="1">MHPFSISMRTALRATSRVKKYSTNSATYSDTVKNLRISKETKVIYQGFTGKQGTFHATKAIEYGTQVVGGTNPKKAGTLHLDLPVFATVSDAVKSTGATASAIFVPPPVAAASIEEAITAEIPLVVCITEGVPQHDMIRITDILKTQSKTRLVGPNCPGLIAPGQCKIGIMPGSIHKRGRIGIVSRSGTLTYEAVNQTTQAGLGQSLVIGIGGDPFSGTNFIDCLKIFLEDKETDGIIMIGEIGGSAEEDAAEFLKINNSMNKPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKISTLEAAGVIVERSPALIGETLHREFVRRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P815</accession>
    <name>A0A0B1P815_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P815"/>
    <dbReference type="STRING" id="52586.A0A0B1P815"/>
    <dbReference type="HOGENOM" id="CLU_407214_0_0_1"/>
    <dbReference type="OMA" id="RDFKINP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="527"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="675" mass="77599" checksum="FA023C5829106242" modified="2015-03-04" version="1">MKSWEAGRIELGREFARICELIDKNISEEINSSTTIPVDRDELQQLRKNSSKVEKLIENNAHLIDELERCKAAAARVDLLEKENKALATEHTHILSKLECIKEPKINLNISPLQTDIVTEGRIDVKEYQRLARKFIVISENCNQLKCAWAKMEKKLREQKRKSREWALRLENRDNIIKRKDQKMKRLEQEFIELKQRLGTDEKVGDCVAKNSSNSISQSDEDFENKTSGNIIDYSIFNQKPCFQSFENPNSLDYDISVPLDKSADKITTENHDAYKLQEREGYAVDKNYGTHYSENQLKLQTALKRKKDTENDDNLSGQKNDEIIRSPFGTQGFQYLRESIDLDDIGEKSITPKKPHSDIRFIGKSKNSKNSVILKYPIAEEVGVYESCRNVGCYQNQDRNSNTLLEKPCLSDTEAKCMSPVISQARGSGFNDLLEQETAKTLSEPRSSIFELRACNQVNIPSNLPFSSPKLSAGDRKSHLELPLCRSSRSKMVKFQQKNLRAQPIEKLDVRDFKINPDYNQGYNYAFSEVVRGNARKKGLQGCLKPCCAPKYRALAEISRDPSKNLSISQQESDRLMLEEFLGDNAYKLQDMSEMDMKELLIQAKTRDLANKHGIHRHAYQNPETPVGIWDADFPTTQEVLEDEKIIIERKRKTVLERYAEAMRPGGAYKFRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P839</accession>
    <name>A0A0B1P839_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g3492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001818">
        <property type="protein sequence ID" value="KHJ32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P839"/>
    <dbReference type="STRING" id="52586.A0A0B1P839"/>
    <dbReference type="HOGENOM" id="CLU_000680_30_1_1"/>
    <dbReference type="OMA" id="NCFINTD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="367" mass="41621" checksum="4F8F2D5430D56A05" modified="2015-03-04" version="1">MALRKILGVFKTAPILPMEVEAALAPPQIRLDTVTRKKKNPKEIVAAHHQEEFYNTNWETTTFIYTDASYMEDSKGVGVSVVATDQRGTIMEKLAINTGDGNLVYNGELEGITQGIEYGSLQARPGHSFRIFSDNQAALHRLAKLSDLPGQDCQIRAIAAAKKIKEKDAKISISWIPGHSQIRGNVKADGLAKKASKLEPLNNETSFASIKFHIANMRNEQWIKYLRKNDDNPRLSRSVYRRKFDWKIISKPLVPRGTRRDIASAFFQLKLGHGYNKKYLYQLGHSNTNQCRCGSIETPEHLIDSCSANKDARHRLKEKLNGNSLTFQLLLHTVRGIEKTVEFLEETNISTRKWHLNRLQGNRDVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P844</accession>
    <name>A0A0B1P844_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001372">
        <property type="protein sequence ID" value="KHJ33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P844"/>
    <dbReference type="STRING" id="52586.A0A0B1P844"/>
    <dbReference type="HOGENOM" id="CLU_063749_0_1_1"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="21975" checksum="CE7C0B58F4A07441" modified="2015-03-04" version="1">MTSRLVLVIGDLHIPDRAIDIPAKFKKLLTPGKIGQTLCLGNLTDKPTFEYLRSIAPDLKIVKGRYDVDATSLPLSQVVTHGLLRIGFLEGFTTVAPLETDLLLAEANKLDVDVLCWGGTHRFDAYELENKFFVNPGSATGAFPTTWINENDQDIVPSFCLMDVQGIGLTLYVYQLRKDENGVESVSVEKITYTKVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8A8</accession>
    <name>A0A0B1P8A8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor iiic-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000846">
        <property type="protein sequence ID" value="KHJ34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8A8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8A8"/>
    <dbReference type="HOGENOM" id="CLU_395321_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="390"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="647" mass="74203" checksum="A2A08E1477E16F41" modified="2015-03-04" version="1">MPRSNLAQLARRKKQTRLNFESVNQSSPVHSSSSKVKNDSSDDSITILPSSHPHSRNDLKYDFRTVEKSLQAKPKDIQPTGKFSELITGRNLYAIPGLYNTRVHAICRIAKNKKSTVKTNGLDSSEGSEAESDIAYSVKKLPKPEAVLACKQRLTHASEINMHLLRNELPCNDPNQSSEDDIKFVNTISNLQKSSSPKKFGSSFRTNNKMIVIDSSDDESPITSSNMLTELPPQKICSPLKRHRVMSKDQASNNGSSPMCRSDIQRDNSDDSEDIVSPVKRMCHTRSKEKKINLKMQSTGSESNASFFLKRRSRQQITKRHRTDKEKALELMKRKRAGERIDFLTESELSSDGSSDDKFETLSVFDDEDGSIEQNERDYDEENIETNYSDFVVNNDDELFGVPDHMAFVPLQFTHTAHKPLKDHFRDVVEWMVKDKVYPAFAREDEVYLQAFRKLDDICQGLAKSKFISTQWTLEFTQALWKYPYFISGPLSEEENYKLNTGVPKCDACNRRKHIPTSYIQFDGQAYDKKTLIAREKTQSNGEVSRSRNKKAYSKQVQWLVGSICKRNAQYSHSLIHWKFALNEWVIDCLSHEGHFNAEKSSAEYTMDTVQLDQYANNIVDTWESKGIIMSLYRDWKIQRKIAEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D1</accession>
    <name>A0A0B1P8D1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative c6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001579">
        <property type="protein sequence ID" value="KHJ33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D1"/>
    <dbReference type="HOGENOM" id="CLU_005024_0_1_1"/>
    <dbReference type="OMA" id="NWAPINA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="797" mass="90440" checksum="37D7C7547A9BE482" modified="2015-03-04" version="1">MDNIKCLSEEKKPHKMVRSSIACARCRRSKVKCVNNGPNSTCKSCAQYNRECTYPAAGSTPTPKRPEAPLGVNQAGETPDSKRRNRKIEDTGRRVNQRMKEDVLDSPILTRKVWDELFELFKLHFSTEMPFLHPPTFRNRMRQAAMPRDPNLVTADLEEGRVLLLGVLTLTARFHPGLASHHSPNGLDPLAASEFYAAPLANALGPTIRHLSQPSIENVQALLMLGLYEWSQTRGLSAWLNVGHQPINDSRTPLPSTYPRDGAMEKEVRRRTLWSCFIMDRMLSAGKNRPTMISIERLAVQLPCSDDQFLFAHNGPTSLFSPKWMTPNEKNVPAPDEGVLSCYLRLVEIFGDLSDWLHSGGRKGEKLPPWDKASKMYTLRRRLKAFYDGLPPSLTFNDANLSAHIEKRNATTYSSLHTLYCISIIVLLREYMPFVPLRCEKPRGPLDHPIYSPESYDLPDGFWDVCAQDVMKATRDIIDIIRTCQDSNALPESPQIGFAAWQASFICAYTLWFPKMDTKGYLVDQTYPQSARILKSKNLLNLTQRMLKDMSPTLNMIKGYYKTSEKINQYFFSICKEYYIKFKRGNSLENFKYYESEFKEFCALRDTENVQPEKSEDCSRTRSSTNDISLIESNGDPIQGIESAYQRQNGSWAPINVSSPVDDDRSKYTPRGQYPYGIPYLQHQTPSPTVVSNGDVNLSPTIGNSMPYNVQSQHPMTFSSAISSSIVPPLLDNKNSASDNDDQSFFRWIDSLESISMNASLDNFAQETSFDQFVRNPNYCGSLQLNFFQATWLAMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D2</accession>
    <name>A0A0B1P8D2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000607">
        <property type="protein sequence ID" value="KHJ34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D2"/>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="211"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="847"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1058" mass="119496" checksum="3C6561DD201987AB" modified="2015-03-04" version="1">MSEEDAEIALLHQLQARQENGDYGNEDTNGTNEIDDSSSTLNSDQINKKLKMDDVTVSSMIPSTGNDDFHDEDGDYDPSSIPTITPIAEINQTEPRPSSQASNRKPKTVGGFIADDSDEEYEAALPSVPLNELQPSSNMPNQLELQHQNKAPPQAIQGSSKSRSEKKPEKLPMNISSNTAGSSSLTGNSTPVTAAAQSGLSVPKARLPNDRTGILEDRIKEDNRGDIDAWITLIKEHRSRNRLDEARAVYERFFKVFPQAAEMWVAYIEMELENDNFTAAETIFGRSLLTVPNVALWSLYLNYIRRRNDLMNDATGVARATVTQSYDFVLANIGNDKDSGKIWHEYIQFIRMAPGNIGGSTWQDQQKMDQLRKAFQRAINVPMSTLNAIWKEYDQFEMSLNKITGRKFLQEKSPNYMSARSANTALENLTRNLNRTTLPQLPPAPGFEGDQEYLRQVELWQKWIEWEQEDPLALKNDEPDSYKQRVLYVYKQAVISLRFWPEIWVEAADWCFANNLEKEGESFLNNGQVANPESCLIVFKKADHLESGLAKEETDKSPAERGAIVRAPYDQFFDTLYDMIKQLKTREARDLAKLEESTALDASISAIISKAEEEEEESDSEKQAREAVKETQAKAIQLGYSTQAEILSRTISVAWIALMRAMRRVQGKGNNKDSNGGSRKIFSDARQRGKLTSDVYVAAALIEHHVYNDPAGTKIFERGAKLFPEDADFTLEYLKHLLSIGDTTNARVTFETVVSRLTQRPELIAKAKPLYAYFHKYESQYGELSQISKLEQRIAELFPDDPKLSRFASRFSGENFDPTAVRLIVSPAAQMKPKVLVQSIEHPNIARESSVTQYNPEASPRSQYIQNTNSPKRPFPLEDFESDLNRPRKLARGESPLKGAAGRRLDQQRRLQQNQGAPAWQSNSVASTVPRDVNILLSLIPRAEYYTSTKFNPSAMVRLLRETIVPDYNTWKTAREESLPPNQRFIGNRPTHTPMPPNQPPRPNGYASYPSPIPIQRSVWPQLQAQAQPQPSNLHVFPGQPAPIDYSSYDRNFSTMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D6</accession>
    <name>A0A0B1P8D6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nad dependent epimerase dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000604">
        <property type="protein sequence ID" value="KHJ34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D6"/>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="377" mass="42634" checksum="8599B06AAB38A0E8" modified="2015-03-04" version="1">MAEKPSVLIIGGMGYVGRFLALYIHQNQLASEVRLVDKKLPQLVWLAPEFDEACSNDKFMQADAGKESSLPRIFGRKNGKQWDYVFNCGGETQNSQDDEVYRARSLALSITIGKEAAKRGIKAFVELSTGAVYKSDSRPSKEDGKLKPWNQIAAFKLQAEEQLAKIDGLCLIIARIAYIYGEYTSKFAAHFLVLARVHQHFGEELKWLWTKDLKVNTVHIIDVTRALWAMADWYAVQGKPRWDEKTMGKTPIFNVVDNGDSSQGKIAELVGKIFNIKTGFHGVAINSFARLNLGGVVDDLNEKFLDPWAMLLKEAGITRPIPLTPFMEKEILKDENLTMDGSRLKTVLEFQYSYPEITEQLLQSVIDSYVRMGWWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8W4</accession>
    <name>A0A0B1P8W4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001479">
        <property type="protein sequence ID" value="KHJ33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8W4"/>
    <dbReference type="SMR" id="A0A0B1P8W4"/>
    <dbReference type="STRING" id="52586.A0A0B1P8W4"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="41623" checksum="5BEC3868E906A066" modified="2015-03-04" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFSLPHAIARVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8X2</accession>
    <name>A0A0B1P8X2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mitochondrial outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8X2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8X2"/>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="OMA" id="KHPVARF"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000008">
        <property type="entry name" value="Mitochondrial outer membrane beta-barrel protein Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="172"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="514" mass="56610" checksum="8999E620A348EC69" modified="2015-03-04" version="1">MADPISSENELFESLRKQVDHKKLEEQSKSVLDRELSSSAKAQERLKELISTNSTLPVKISSIQVIGGTQTRQSFLDRLINSIGKEKNNTTLTLSEALREADVIADKLSRFGIYHPKILTYVDTSEKHYPNLTPIPIDIYFKTQERGRVSLKTGTDFGNAEGSAYGNLTWRNIFGGAELLNLNASAGTRTRSAYQATFETPLFSDPDKKIGLDIFASSTLKPWASHEEVNKGVGLRYDWVSKSESRHQIGYTGLWRQITGLATDASRTIRHEAGDSVKSSITHIWTSDHRDHPLQPTRGYLLKSISEIAGWGPLQGDVGFLKTEIESAFAFPLRVPGLKDENGISFTNGFRAGVLYPIPTGFGKETSPSRINDRFILGGPTDVRGFKISGLGPRDGQDSVGGDIYAAASTNLLIPFPKTGKDSPLRFQIFANAGRLLALSGERSKETNKLDYRKNLVNTVSELTNGLPSLAAGVGLVYLHPVARFELNFCLPFVLRKGEESRKGLQFGVGINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P979</accession>
    <name>A0A0B1P979_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">EV44_g4903</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001162">
        <property type="protein sequence ID" value="KHJ33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P979"/>
    <dbReference type="STRING" id="52586.A0A0B1P979"/>
    <dbReference type="HOGENOM" id="CLU_063953_1_0_1"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="27"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KHJ33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="30026" checksum="37C51E0E7BAE63DB" modified="2015-03-04" version="1">MESLSTDLTPAEQPLRPTISLPIIFANSSLKFVAQGAEAVLYKTSYLLPSQLSALKLRPSKHYRHPILDARLTKHRILSEARVLIKCRKEGVPVPAVYALDEKGGWLMIEWIQGVVLRVMFNDWLRNQTECDMRNLHSNETLKGIMRAIGLAIGKLHSIGIVHGDLTTSNLIMKAEQLNDNLPPNELIQGEIVLIDFGLASQSSQDEDRAVDLYVLERAFGSTHPQLEVLFSEVLDAYKEGFKNTKTVLRRLEEVRMRGRKRTMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9K5</accession>
    <name>A0A0B1P9K5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative subunit of the trna splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001306">
        <property type="protein sequence ID" value="KHJ33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9K5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9K5"/>
    <dbReference type="HOGENOM" id="CLU_028449_2_0_1"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="51565" checksum="3B3682149C28A376" modified="2015-03-04" version="1">MIDLDEEVYLSTSHGTQLYEENDPSDETLDFRFANLTSVNSGGQLPKRGEKDFEPHGTKHQEKILESSRQAMHDALAHIRSHAPKNHIRGFYYGDKRCANREKMFEKQFRHGLEDDHVVLVESARGPHFKIMGKMTTKSNNPKLWLLPEEALYLVERGFLDLWWPSEESFSENVVDEEKGRDEGTPMSLQAAYAMLIGNENEKGKVTLDWYTVYANLRRTGYVVQRAPSQKTPKDNQSEINHTSQSTETQANLFSWLFGSSFFKEKEESSQYSSLVKPGMYRSYNAIYRKISVIPRHKPVMSHSDSTISTDNIYRVVYFLWKGDNLKTFTKKNPGDPDYRVAIVDAHSTLIPSLLQVKSLLQSVPFNPPNSEKLKGPGKVFQRLKHGWRHVTLAIVDQGVISYLKLVEGAFGEELMYERFDSNSMQGTKRGYRGGVGRGGRGRGRGRGRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9T9</accession>
    <name>A0A0B1P9T9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001279">
        <property type="protein sequence ID" value="KHJ33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9T9"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="YQQNTER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="319" mass="35610" checksum="BE551479CED9A37B" modified="2015-03-04" version="1">MPAIRPKRTYTMIDVARDRANEDTNESIPSTPIEETDSHVCKINQPYQQNTERSKIPSENSRKTSIAPFFPQTHDLRAKITQRSENSPEIALEAHDVPPELRKIIEAEKHRAAEITANLRTCTIAINGVQKAPSTAAVDGNKEFSQGLLIYIQAAIAQFMANGPGTTLPVLSSKPTQSRQVKQKENSTIPSKKALPQKLQNTEEKTWASIARKENQVTPAILTLPAIPSSTQIHLRADKEKGKHSKPSTGDDRLFLRLTKEHEWRPLAPSAIRKMICKHLECSLTDILLIRRTETGFAMSAKVKETRQLLLDKSSMISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA21</accession>
    <name>A0A0B1PA21_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA21"/>
    <dbReference type="STRING" id="52586.A0A0B1PA21"/>
    <dbReference type="HOGENOM" id="CLU_035996_1_0_1"/>
    <dbReference type="OMA" id="FEPNNTS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="450" mass="49897" checksum="E5540979EAC521D2" modified="2015-03-04" version="1">MFYKGDLQSAINEAVKDSKLVACFVTDNEEESQLWENEYLQDPRIKKMLSVQSVLLRLEAKSTEAGYLAAIFPIPTMPTLVVIKDGQLKEYLTSGIVREDFQKRLISVLYPDEPSLQEPPPTTLASEESGQASTESLIPTQALNTSVAPTTAKAEETSRNHIDDLAPDLKPQPSSKPSALLDQKNVFKQKKQQERDERARILKRVEDDKINRRNEAARRKEERQRTNNTSAGEPTQTGLDKRMPSSQSHDTTFLLFRLFDGSTIRTKFPSAATLSNEVRNYLSENQPAISNQPYVFKHVLSPLPNRKIEAAEETQSLRDLGCVPSATLILAPISDYTEAYSLGMGAKASSLVGGVINNGLGLVRGGFGLVTGALGAVIGGSVADNRGNDYHQLKNDDHAVSQMSASTNVRTQMSRLEERNCMDEPQFYNGNSVNFQPRPKNHDEEQAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA90</accession>
    <name>A0A0B1PA90_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000979">
        <property type="protein sequence ID" value="KHJ34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA90"/>
    <dbReference type="STRING" id="52586.A0A0B1PA90"/>
    <dbReference type="HOGENOM" id="CLU_090091_1_0_1"/>
    <dbReference type="OMA" id="DIQWATF"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="156" mass="17717" checksum="480624062FF6902E" modified="2015-03-04" version="1">MKEKSTSNNPSNSSGKGRRVAGLVAQSSSLKDVLRTSSCKKPTWPSNCAEDANSLQWSSFDSSILHAYRYDYRLDTPAAFKKPYNHIALSRSPIGKYSPTMAGRRDQKRQSKDQLADAVCNHFKCMGIVENDVVVEFLYKVHYQDKSFRMRFAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAB7</accession>
    <name>A0A0B1PAB7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001165">
        <property type="protein sequence ID" value="KHJ33886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAB7"/>
    <dbReference type="HOGENOM" id="CLU_589496_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="464" mass="53215" checksum="4DBA9CDB34D5D5F4" modified="2015-03-04" version="1">MVSEALQIAFSNERRDSIRPYVGSLYSNELGYLTWPIVQDGSSSKIKKFSPSAHWLKSTYQVVFAKNGDVIDLIVRLSNHDFAKCRRHDNYQLETQEEEIDPVKSYFCGARYIPKDDIERSIDYFHEFVEFVAEKKTYPASYRGRKYRKDLGLQVWPIYRGQNLYSNPKNTGGPYLILVDSFGQLKRVIARTYDYDFVDCIASSTEIPAHVTHSKGEGSTQSKGTTRSGFDCNGIFFDDKELHLARNLARESRRSRHNVFPVEHFSPPCDLPCLLWPLKPSGSTMRNGMMPCSLFLSTLDILVDIFTLGNLAPYRLVMSLDFQILFVALKGHEKMKKCERRTIAGGNINHDQSSFRCSTTVFHNSEVLAVVHKACKEKMLHSKKYPMSYEGENFQVPGPYLIYPLKKGKEYNGGCMLKILLNFTTNFGAPTEIGNRARIEFYGNELRLHTRRSFDDKKKENIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAG4</accession>
    <name>A0A0B1PAG4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative chromosome 10 open reading frame 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001133">
        <property type="protein sequence ID" value="KHJ33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAG4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAG4"/>
    <dbReference type="HOGENOM" id="CLU_029861_1_1_1"/>
    <dbReference type="OMA" id="YEATHLN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="629" mass="71055" checksum="FEEFD9320AF18CB9" modified="2015-03-04" version="1">MEISPLTLQARPDVFQNKVVSLYKELFSVDDDQETTEGFWRVFFLLKPDKSALLRLIDALSPEDFLSLQTETQQLFNKAVKCIRAGKGPADLNALETCTALMAAIFRKKYTNPSSDVIDLLAGLDQVDKIFTDFVAALDITIRNGRSLDLRQKAVESALCLVSGAYQTSLLSYFIYRDLFLSLMKFIQDSETISRSFRSFILLGLLANYNKFEFQNPYQLRLDDFVNEATIQKIIRSVGYTCSKLRGEYVAIQNDSPEGWSISNTLSMMGLSAIAPRAVSSAPPVFDAEVAKEMFAKLPGSEAAVLLATYDFTNANKLFCLNLISLPAEKDLESPISSLLSLISYLLQHAHTSSRTTNYSHLCLLIIRILVEDQTICKQLCSDENKITTRLCRQKSPYLPYVHGDRSIAAILLDAMLDGINHNLRRRLDVDLYILCIGIIYSILSYLSRSRTRLKYHWSELYRSLLSLVRFLTTYTSDLRGLKNIDILIDNLVNLIALSLCCGEAFLHSPVSHYDLFYKVVEMGEVLVKFRDNFSLEKRPKNSIDTLISVSAHYNHLLQGSGSEKKKKNLTSTQVASVIKQGYESLSIQAKDGLENCEKYREADKKAFLKQVSRCVVADVKNFIWEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBM0</accession>
    <name>A0A0B1PBM0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000731">
        <property type="protein sequence ID" value="KHJ34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBM0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBM0"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="278" mass="31437" checksum="3757BE387029F45C" modified="2015-03-04" version="1">MKTLPDAYKIVQWHNNVAKYDTPPQRKEDSSDIRQEPRAKALILHQVLLCGHLDTEDISANTPKVAQRQISWQPFSTEEAYRATCKVNSTTLGDDEISCSAIYYRSAVDLTTALICDVKKAWENKKVVGIITTDLKAAFDGGLRNRLCYRLRSQGWPKHVVNWVSSFMSDRSAHICLDQSKTESLPILCGLPQGSPVSPILFLLYVESLLRLSRGCYGYADDAAIFAAGKTLEECNSKLQFQLDRALEWGIENGISFDTLKTELQYFDRKRKYSLPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBS5</accession>
    <name>A0A0B1PBS5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001044">
        <property type="protein sequence ID" value="KHJ34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBS5"/>
    <dbReference type="HOGENOM" id="CLU_2741934_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="71" mass="7967" checksum="6086E8EBEFB808A8" modified="2015-03-04" version="1">MYSHTIITNEFVSNFEFNFCLLDCQHIGPPPSIATYPLTERRVDMSEAKSESEKITAIISLFISEDGGPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU4</accession>
    <name>A0A0B1PBU4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative u4 u6 small nuclear ribonucleoprotein prp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001030">
        <property type="protein sequence ID" value="KHJ34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU4"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000698">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="56979" checksum="9561B5F772788D84" modified="2015-03-04" version="1">MHPARAAYVEKAELGQGSISLADLPIDHDMPIATGGIAPERASAILSQLDRKRRAAQISVPTDDGRVRARLREMGEPMTLFGEGPGDRRDRLRQLLAIEEEINAAESDDGDEKMEDVFQQNKIEQEEEFYTKGIPELIEARKAIARYSLPRAKIRIASEKFESGIPLRTHVKSRKAIKERLHSIELYGSQMAGERPVSMTRFSPNGEIIAAGNWGGGIKLLSVPSMTEIKTLRGHTDRVGGISWYPDATLASATVTEDSVNLSSGGADGLVHLWSLTKDVPLSTLTGHSQRVCRVEFHPSGKYLASASEDTTWRLWDVNTTTELLLQEGHSRGVFALAFNTDGSLLASAGMDSIGRIWDLRTGRTVMILEGHIRPIYALDWGADGHRVLSGSGDGWIRCWDVRKVQPSGGIGAHKSVVSDLRWFKGLDDPSRGMQPEFDEHGARKPKKSGTFFISGGFDKSVNIFSVDDWSLVQSLRGHTGNVHSIDFTKDARWIVSGGYDRTIKLWGMPDNEGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD1</accession>
    <name>A0A0B1PCD1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000785">
        <property type="protein sequence ID" value="KHJ34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD1"/>
    <dbReference type="SMR" id="A0A0B1PCD1"/>
    <dbReference type="HOGENOM" id="CLU_1099179_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080612" description="Secreted effector protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28707" checksum="E361FA7FEDC146EA" modified="2015-03-04" version="1">MHFSLSTANALLLVYFFVSISEAVSTCGRTPEPTPDFDCDGQLITGNRLNGVVCAAKRTAKYNSILFIKKKQELYNGPPFMNSYFLLPISLQTKSYQKASSAPYRAVLTKNYGVFSVIMQERNKVKECRMKAEVTEKHRQLDFNCSGQQFHFFELIKAADLACKKILRATNEQFPARYDGNLYEEHGKQRYIFPIYVRGFYDGTQPAGSFRVVINSKCQLVGVLRYDSNSNSQKCLESPSLMFPSLTMGILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE1</accession>
    <name>A0A0B1PCE1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyl-synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000960">
        <property type="protein sequence ID" value="KHJ34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE1"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="OMA" id="ARNSPQW"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="103"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="690" mass="75561" checksum="D7787DE5E7C6B70D" modified="2015-03-04" version="1">MYRYATTSPGIYDSPPFSIAIKSSENATESCAHRHPARLKGLVAAPRPEISTIYDILVHSATNYKDLPGFGSRKLIKLHREIKKTKKIVDGEEITEEKEWTTFEMGPYEYLTYGQYSDMALTLGAGLRSLGLVAKDKVHIFAGTSMSWLAMAHAAASQSLPIVTSYATLGEEGLTTSLTQTKASAIFTDPDLLSKLINPLKVATHVKFVIYNDQNKLKDSDIELLREAHPNLRILSLSALQQVGTSNPTDPVPPSPDDLACVMYTSGSTGIPKGVSLTHKNVIAAVAGINSVFYNFLTTEDSILAYLPLSHIFEYTYENTCMFWGLRIGYGNPRTLSALSMHNCEGDIKTFAPTILIGVPAVWETLRKGIEAKVSGSGRLKRSVFHGALRTKEFICERSLPGAEMVSNFAFSAILEGTGGRLRVCLNGAGALDEKTIKFISYNIAPLVAGYGLTETCAMGTVQSPLQWSPNSVGAPVGCTEIKLLSHPDLGYYADRTPPRGEILIRGPSVMQGYYENEEETRKVFLKGGWFRTGDVGEWDVNGHLKIIDRVKNLIKMLGGEYVALEKLESVYRTSPLVLNVCIHAESNFSRPTAIISPSIPAITSLAAGHGLDSSSQSLTSFLNSGSLKNLVLRELQNVGRKAGLASFEVIDYVVIVEEEWTPESGLVTPAMKLKRREIIDRYGKYEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCF9</accession>
    <name>A0A0B1PCF9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2648</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000779">
        <property type="protein sequence ID" value="KHJ34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCF9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCF9"/>
    <dbReference type="HOGENOM" id="CLU_023050_0_1_1"/>
    <dbReference type="OMA" id="WFEESSN"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="513" mass="57685" checksum="5C09A03B68CE5E42" modified="2015-03-04" version="1">MLEHENLPTCNSLVTKDATNLLSNFDDNVNCANSSCFEGPEKLLEVWFAPAPDALPHGVKENGLKSVNLQAWEEMLNLVNCKILSVIESKNVDAYLLSESSMFVFPHKLILKTCGTTTLLFGLSRILNIAVIEVGFPQSERNATGESCAIPYRVFYSRKKFLFPDKQQGPHRCWENEVEYLDNIFEGGSAYMVGKVNGDHWYLYLTLPNTSILTSSTTEDSSRNKSLKVNYNSFCPGSQEKENHDETLEILMTDLDQENAKKFYVDHANKVLASNISADAKPKWHNMLDNMEGFHGSMKSSKQLNRIKIRMPKDEEKHSYILSAQSGFLTPPKETSDEAEITQGRALGAIVTEMCGLLDVFPSSEYPNACVDSHLFSPCGLSVNGLIPSINDATAYYFTVHVTPEPHCSYASFESNVPTRLQGRDTVDVVKQVVEIFKPGHFSVTLFEEKKDSIGEVKKCNINQGDVTDNSYNKNKYSNLDKITGYNRKDRIIHQFEGYNLVFCSYEKKAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCN4</accession>
    <name>A0A0B1PCN4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCN4"/>
    <dbReference type="HOGENOM" id="CLU_018153_2_1_1"/>
    <dbReference type="OMA" id="TKITYPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="21889" checksum="122E95A460DF088F" modified="2015-03-04" version="1">MPAIRTKRQFSMVDIAKSRARARLKNKGLAPDLIDIDTVEASILDTESPDIEMIDAEIDRLIAKGLKESRWATPQAQAASSTKATTVDSTQLIVIKDMLAPTPEAESRAQKDKGIAAQRPITIDLTASQISSLSHNKSISITEPQASLNINETGKEKSYPPELQAIFEAEKRRAAQTAANLEVCTAAINGVETALLPLRVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCX6</accession>
    <name>A0A0B1PCX6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pathway-specific nitrogen regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000706">
        <property type="protein sequence ID" value="KHJ34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCX6"/>
    <dbReference type="STRING" id="52586.A0A0B1PCX6"/>
    <dbReference type="HOGENOM" id="CLU_400194_0_0_1"/>
    <dbReference type="OMA" id="MENNTRQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="688" mass="77867" checksum="309A7BFF8E159EF6" modified="2015-03-04" version="1">MEQQVLFQRDEIQTILSSSSKNICDDFENQISALEEEEYSATACGNNSEMENNTRQQIKEIEAQIHAAAKAVITSLEQDNMIESQDRITRLHSGDSFTNLNLANAGSRKNYDVPRKSSLEIENHSENGTGDSSSQHDAAIDDDVFSHSHQSKRSSWNSYQELINPEDPSKSFSLIIDTGEETGIDTEIISSVSNGKSPKKKGSPTRKVGKNISRSAFRTPSSVRAIQMSSPVHSSFPSSYSAQQKTPSNSQHGNPVSYGSLTKMTPSRLKPKKEDPLVLLHLTVMPLNYTYSCLTNSPELPESLKSIQESWRLLQDKLNDTVLERGVLLAHPQDSFETLEERLLEALELPASPRARILKCGHYLRSSSSETASSSEEISHMITPPKTRKNYKLDSRLCDVCGREIRPLDFGNKEKNFRIKIYASNGLMSAGAWAAAWREMERVDVEIEPYVEAHLNLEFKLFAARSQQFIQTTEKNKNFQYVDEEIIIENSFDQDDELEKGEEELKIEAEIREYEKSEEIRLRTVQEMEEQKEDYMEIKEEENITGHIKIETECRYRPVTHENEPNQSLKLDINQTQKSKLNRPQDSLVQLLIAATKVVLEEKRNLIIAVIASILLFYLVFFKSTSTTSLINIESVISSQNTQSNSINVDTSSTISLDVVTTTVFHEITVTRMLPTPSTCSRKIYPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDM5</accession>
    <name>A0A0B1PDM5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative abc1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000380">
        <property type="protein sequence ID" value="KHJ35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDM5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDM5"/>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="OMA" id="RCNPEDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="172"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="67233" checksum="D3E787BE07575CE4" modified="2015-03-04" version="1">MNGTSLLLSQSRRGVSTNVKWICGRKFSTSGLGLKQSIPHLSNVKISNPNKEGLKKKSLQVLTVVAGISGLAATLFYKDDLIHAFQASVRTGRVLKTMVICMNDYRQTLNQNDQIEDKEEKNKLLTACHQRCADRTLKTLEDNAGIFIKLGQHLSAMSYLLPLPWTVTFIPLQDKCPVSSFESVGTLFKMDTGQDINEYFSDFSSKPIGAASLAQVHLATIRETALPVAVKIQHPALAEWAMLDLELIKFTFSTVKKFFPTYDFDWLSKEIEYSLPLELDFTKESQNAIRCKEYFSKFPNIPLVIPDVIWAKKRILVMENVSGQRPDDLDYLDKNGIDRDEVSAALARIFNQMIFGKGAPLHCDPHGGNIAIRKNEKRKGCNFDIILYDHGLYRDIPIETRRSYAKLWLAIIEADEPKMRQYAREVAGVTDDKFVIFASAITGREFEVVTSDISKKRSAEEKMHIRKALSQGMLQDLIELLSKVPRIILLILKTNDLTRNLDENLHTRYGSVRTFLILARYCSRTVLEEKLEDLYNRKNLLWPSNLFSLFRCWYDFFRVQVKLELFELHEFFRRNWQDFKELKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE43</accession>
    <name>A0A0B1PE43_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative major facilitator superfamily transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000630">
        <property type="protein sequence ID" value="KHJ34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE43"/>
    <dbReference type="STRING" id="52586.A0A0B1PE43"/>
    <dbReference type="HOGENOM" id="CLU_014401_1_1_1"/>
    <dbReference type="OMA" id="CNILQQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="62080" checksum="84110DE0B2370B8B" modified="2015-03-04" version="1">MSTYRHMQVSLLSTKGDMAQNDSATACMLTDSERSKSLAGAQSSRDLEISISPSSIESSNSLKPKDVINIESIVISRSTKIIQIAIAVLNCFLSAGIVFGYAALKPILIEEQTYRNYCTREELDQNIRVCVQQEIRLNLMFTVAVVGTNVSALPVGIILDKYGPRICGLISSASLFIGALLFAFGADLKFDGYLIGYFFLAIGGAFTSMPYFHLSNTFPKNSGLILAMISGAFDSSSALFLIYKNIYFQSGKSLRPKKFFLIFLIVPVSVFLVQLFFMPKLSYKSIGEEKGVENSEQQTTKIQDDSNENTALLGAGLAKQNSLVTSESVNYLSLESARKQAIEEEKKKKISGIWGIMHGKTVKDQIFSSWFILLTLFIVLQMIRINYFIATVHPQYEYIFGSFKDADEINAVFDISLPIGGIVGIPFIGIILDNTSTLSVFSLILTVATTIGSLGCLPYKWAAYSNVILFVLFRPFFYTALSDSTAKIFGFTTFGTVYGLMISISGLCNFVTNGLDQLCYQIFHRNPIPINVFLLAATFVIGVVLCCFVKLKSNMIRNMINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE87</accession>
    <name>A0A0B1PE87_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosome biogenesis protein urb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000477">
        <property type="protein sequence ID" value="KHJ35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE87"/>
    <dbReference type="STRING" id="52586.A0A0B1PE87"/>
    <dbReference type="HOGENOM" id="CLU_009575_0_0_1"/>
    <dbReference type="OMA" id="RYITFKR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="103"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="3">
        <location>
            <begin position="644"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="903"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129079" checksum="E32E7A2A475FEC25" modified="2015-03-04" version="1">MIKRSSKEAKLTEQVNSKRLKVSDSASPLSTDILKITSGKQLQQLLTFSQDKRNSFNDIQTFKSFLDTIIAGYDSQAKLLILKEYFELQKSYSGDQNSGIFLCDLIKIWSFASESNKENLLSAVPSVLALLLKITSNSLELLTYGISLGKVLLHKDQFELIKRGLSANKNKEHVISPILRLLRELSMLDGGALANSVYKARNATFQAMVRNLTLGYTGHGNEELRKPSVRTNAIRFLLQLVKHLSTESKADILSQRDIFSTLIRDIINDPPFLVRDILLTIEIHIIKDASLPRDAKTKLLSSRFLVNIASLYRYNKSEEKNEISTSSVSESAHKFLLLACSSLDSGVLLKQSGLYPRGLVINICDENNTNLNNKQFDLGLDSIEWIDKYTEKVPVRNSILSEFIHSLKPWSNIRHAELIISIFKAAPELIAGYFSGKNNFLFDPKLTAMWVGYSNLIYSTISLSIPNYFGYEDGYANLPPPLPIMMEHILPRKFSQKLIIKCLGQTTNSLIMFLTARIICISFQKLEAALQMYKQASRGPSASIWNQYASMVIENYSRRIPAISHIIGAYRRLTSTNLCQREVFTKLISLYYEILPHIALETNSGVSSIIAEGLLTIDKTNLRSRDGILCALELENILRLARLSPGMKWFSNSNGLSMSPFLATLRFYALAPREYLLPRLRSVLISIFHESQILQTCNSNAEFDYLIMNIRSILNDNENSGFFKYLDSCISRCAATPTKYIFMLEDLISETGNNICEPDISLLLLAMLEQWPFHVRLADLSTIKITSRFIARYLASSRKLKKDKSMIKCLSKKFSVACADKSEAQCILKSYKKATIDITIPENEFRNSTKISTSIKHTPQVIEKQPRALFEKIGLDDISETNNALTRWRKKDIEDVIEDGYLKSLIMLLSSKHCNIRREALINITKFSHQLKESKFEEREQIWLLLQELLESSRIIINQKPLTSIFSCFASYAVDVLKDPSHSLYPKVNQFLSQKPVWRLDQIPMMHRLIDESPSLDVAVYSEREWLINILSDGLCSEADLEIYRKRLVFERILSCYNYNFGLKLQNQILNILAKACLIKGGISTLVTRFSLVTWLEVQDSLSSNIAVKELYQSLLQSCGHKRVKAWSRGTIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PER7</accession>
    <name>A0A0B1PER7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000411">
        <property type="protein sequence ID" value="KHJ35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PER7"/>
    <dbReference type="STRING" id="52586.A0A0B1PER7"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_4_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13708" checksum="FED4BAC083C2AE7A" modified="2015-03-04" version="1">MINGSPIAWWSKKQTMIAQSTCEAEYAALTSLVIAARWIRPLYEELFKVAPSPIKTEIDKTAAMITANTKKITARNRHFLMKESTIREAIKDGIITLEFTPIDKCKADGLTKALQRVIISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG27</accession>
    <name>A0A0B1PG27_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative yap-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000093">
        <property type="protein sequence ID" value="KHJ36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG27"/>
    <dbReference type="STRING" id="52586.A0A0B1PG27"/>
    <dbReference type="HOGENOM" id="CLU_011932_0_0_1"/>
    <dbReference type="OMA" id="MQLQPED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="598" mass="67911" checksum="75BF92CF2B29DDE9" modified="2015-03-04" version="1">MASFLRESLPPKCDYITYLTIIESHLSPEILPTLNEILQDPDLTQNIGWDLIHLLLPIPNSVQCLKTIAKYGNPREVILKVTEALQLLKPHSEQENVEKNMEAEPTDNQKFCLLIDLLSILHPRIKTKYPSRFLSTTLKSILATYYPSEPATIAIISFILAIFEKKKFSSLEKFSSIRLQDCDKKVKALAPDPEAQDEDPQEEKIQIKLVQSFVTHVIEKYISENPLDWAPRLLEHLHPKKVIERRSIDKAFREDPVLHAREKIVGQLMDISQDFGLMQHDTLFAVFVKENPLVEQEFQESDDFLDNLPTSSAGSLLIAANSIFASIKLKSQLPLPQLTIFPDHVRLVKIFIEAQGSDLIAGKLLGVIDAILLLGLWLESENKFVSGPLDDEEFLKYLQWLSYLSTITPSSSLRSAAHILSSSILHAHPIDRLRLTFISDTLENCPYESLKASAVSWLKEELIIASERNTNNVFASTTALVATQPFLFPATLGMLDASDKELIDEVNNSFPFHMAVLNFLVLLCGNKYHHILPTTMLNVAEEIYVRPLKTVCKKLLDMRFNNPKLESEITKMELQLLEERLNLCLTELARANRLEDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG38</accession>
    <name>A0A0B1PG38_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cnl2 nkp2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000092">
        <property type="protein sequence ID" value="KHJ36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG38"/>
    <dbReference type="STRING" id="52586.A0A0B1PG38"/>
    <dbReference type="HOGENOM" id="CLU_077446_2_0_1"/>
    <dbReference type="OMA" id="REQDMDR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="194" mass="22145" checksum="704FC3AFD59CEA3D" modified="2015-03-04" version="1">MANSHTELSILTKFLLSPAPLPALISLKTFTTLFPHSQRSSPAIRALYRNLQTSRLQTIDQINQNIIKESKKGTKQRRIIAKARQEEKDDIRGDVEIELEEIALGPSSNLPISKPHTLESIIVELSLAVDDLEIECKFLEEEEDKILEYLRMIIGGLSDLRYGKLKNPHLRNQVLERCLRLENFCNENVSIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGS9</accession>
    <name>A0A0B1PGS9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000011">
        <property type="protein sequence ID" value="KHJ36465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGS9"/>
    <dbReference type="STRING" id="52586.A0A0B1PGS9"/>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="OMA" id="EFFGQFD"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="38"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="45676" checksum="92A54A4915EFC355" modified="2015-03-04" version="1">MEASINSTSKPIDHSSKPCIEVSKCAVAGISADEIALYDRQIRLWGVQAQEKIRSAKVLLIRMKALANEIAKNLVLAGIHSLTIVDHENVIESDLGSQFFLSESDIGNNRAEASALQLRKLNPRVQIHVDQSNIDEKSSEYFRLFDVIIATDLGTQSLNNINISTRINHKPFYAAGVHGYFGFIFSDLIQHEFVVERDRCNKPTTNGPETRTRSVIDVKEKKENGKNFELVTKRELYSTWLLASDVAGLPSEFKKRKNRLRAVTPILSCLRAIWNFTQLQDGNFPKTAKDLKTFTVLATQKHKALGLPDDTLRAEVLRRFLQNLNSEIAPVAAVLGGQLAQDVINVLGARQQPIQNMVIFDGTSMDARVYALHPEGALGEAQLPPPIHSKPSFNSSGAAKCITSHLSEAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGX4</accession>
    <name>A0A0B1PGX4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative cd2+ zn2+ transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000273">
        <property type="protein sequence ID" value="KHJ35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGX4"/>
    <dbReference type="STRING" id="52586.A0A0B1PGX4"/>
    <dbReference type="HOGENOM" id="CLU_013430_4_2_1"/>
    <dbReference type="OMA" id="CLFHQHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="431" mass="47400" checksum="3570D337CEE655CB" modified="2015-03-04" version="1">MSSPSKSSRLITMLIIDITFLALELAVGIALGSLALMADAFHMLNDIISLSAGLWAVLVAQSSTSDKYSFGYLRAEILGAFFNAVFLIALCVSIILEAAQRLLDPPKINNPKLILVVGVFGLASNLAGFFILGGHSHSHGVENFNESFDHESHSHKQNCDVSERDTEHENHQADDSYQTEHDPLITKKSSRKSFLVPSLKNKKLDKSHHEEHNHKKPNTHKHGGHDHSDLGMDAMILHVIGDALGNIGVIISGLIIWLTQWHGRYYADPAVSLFITLIILRSAIPLTIESAKVLLQATPDHIEVETIKKDVESLPGITNCHHIHIWQLSGTQLVASMHIHFEFSMNDTGGEKYMDAARAVRKCLHAHGIHSVTIQPEFSQPSNVASNSDMQMSSSLDSSIGQLRYNLVADKCLLECVDNCQGKPCCNPKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHS1</accession>
    <name>A0A0B1PHS1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000148">
        <property type="protein sequence ID" value="KHJ36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHS1"/>
    <dbReference type="STRING" id="52586.A0A0B1PHS1"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="406" mass="46949" checksum="7933310EC31CDEF5" modified="2015-03-04" version="1">MSTPITMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFTLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMERKMTTPVESLCRGFPAEFTVYLNYARSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNQQAACSQQAIEEEEKPGRIRTVNATNNLTSLKPPKATNPNLAKTSYVYSSVPQIQRQYYPGMEDMRDAKKMTGNNADKNKTIIWGMNDFQLFFCSGVRLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUG2</accession>
    <name>A0A0B1NUG2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cycloheximide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005663">
        <property type="protein sequence ID" value="KHJ30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUG2"/>
    <dbReference type="STRING" id="52586.A0A0B1NUG2"/>
    <dbReference type="HOGENOM" id="CLU_008455_1_2_1"/>
    <dbReference type="OMA" id="FMSLQMY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="56881" checksum="E44752B37FC044D8" modified="2015-03-04" version="1">MATTKKSALDQPGSNFLLSSNLNHESKGNNITVNIFSEKSEEKTISTISGDVSQEFDSEYLVSWDKQLDPLNPVNFSIPLKILNTGLITLVCCLNIAAIGILAPSASSILSEFKAQNASLGSLVVSIYILGLGFGPLIMAPLSEVIGRVPVYNLSVFGFVIFNICCAKSTSLQILIFFRFLSGVFGSVTETNGGASISDLFSPSQRGLVLTLYALGPVIAGIISPVIGGFITDGLGWRWIFWLLAIMSGIFGTLGMVFLRETYAPVILERKAARLRKETGNMRFRSVFQNNTSSRKTFLLAFVRPFKLLIFSPIIFSTAIFLGLVNGYQYLMLTSYSSIFRNQYHFSISAISLSYLGAGVGCLLGLFIFAIQTTILYGSQKNKETGLEPETRLRGIIWTYALMPLGLLLYGWTAQEKLHWLLPILGTGVISCGSLHVFLCILVYVIDCFPLHAASASTGNTFLRNSVATVIPLAGPPMFKSLGVGWGCSLLALISCILLPFPWTIMKYSATLRSRYVVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW19</accession>
    <name>A0A0B1NW19_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003944">
        <property type="protein sequence ID" value="KHJ30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW19"/>
    <dbReference type="HOGENOM" id="CLU_071130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="37737" checksum="860B71018C5CC8B9" modified="2015-03-04" version="1">MNTIHDLTLETPDPFQSPTSTPQHTHSCDKVVENTQPHNPTVTNEVDMSDNPPLSNFHPNSPNQTTIRKDLSNFIEEQARVFNARLAEAQHVINQFTTLYESISDPEIRAAMNEAAVGIKEQLRAILTGDIKKATNPSQPNRKTLIPKTVEQKKPTKTKDQTAMPTGQYKEQSQTNQGASANKNIKSKAATQKTWTEIVRRRPAKNVVDLQTQEKFILPSIPPENTPKVISKPDPRLFLRMGQDHPWRRVSPHYIKISLAEKLKVASSAITQVTKVNSGYAVSAVSEIMRNALLTQAHRLEKTELKLEPASKWVSLLAPNVPDKLFSISGTVSDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWI2</accession>
    <name>A0A0B1NWI2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative set domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003700">
        <property type="protein sequence ID" value="KHJ30727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWI2"/>
    <dbReference type="STRING" id="52586.A0A0B1NWI2"/>
    <dbReference type="HOGENOM" id="CLU_020840_11_0_1"/>
    <dbReference type="OMA" id="HHGNISH"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19473">
        <property type="entry name" value="SET_SUV39H_DIM5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="165"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="38509" checksum="840C5BAA6D9546FA" modified="2015-03-04" version="1">MNLSPLSSLPMQLAHSLRHDDDNPYLEPERKKCHWCRFRQWESNKMFPVSIVNKETSDTIDNNFEFIERNIIREGVELADEDFQAGCECVTSYNCMKGGCYCLEDVDTSGKKEDMRINAYHVVGRRKGCLRGEMLRSTMPIYECNKQCNCPEDCPNKVVSRGRQIPLQIFRTMTRGWGLRSTEDIKKGQFVDSYVGELITAEEANWRRAQSTKSQKKDVYLFALDKFTDPNSSDERLRGEPYEIDGEYFAGPTRFINHSCEPNLRIFAVVRDLANKPFHDLCFFALKEIPRFTELTFDYAGGVRGEEKGIDHMEEGMTRCLCGSKNCRNWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX58</accession>
    <name>A0A0B1NX58_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003977">
        <property type="protein sequence ID" value="KHJ30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX58"/>
    <dbReference type="STRING" id="52586.A0A0B1NX58"/>
    <dbReference type="HOGENOM" id="CLU_006301_8_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="623"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131982" checksum="761A78B60AF69ED8" modified="2015-03-04" version="1">MKKPNLIKETALCVFCRHRFKKYSSALHIQRKYFKFSHTALQRQKEPDNDPFASTNNFTGATWGISPEVQNETNKVSTGPTEKESNWGSTDDISSWATPIAKEFDNKELAATILSPHKSSESTENWRSIPEDQQAEVRELKLRPFPGPQSSRAGRPTPPPRPLVRRLKPSDNNYQSLNYHNHDIKTKNHAIELNENFSFKHNSNRSQIRRSNLEQSWSLLKRRGVTPVPVLNPVVDRSRDPMAERDREEREANLKNFAVDRKEREREAEFRRFTPLIGHSSFQEDNPPYKKTQENILKPSVENSKSSTLALPHASDVSNGIKSDYMKGSSKEVRYGLENLNLTVTKSSKPLGSWEELDYPASYGQNNMQQFKRNKIEEIYSSKIQEPHEMRYWQLNPEDIWKKNLNFTSDASQPRGSRLKNLLAEQATTRMLPTLPKKTLNSRSVLMPEDTPLEETVEEENEYIIKPKRKKEKKKRGIESRPLYEDEKSKLVGKDRDRARRDARILRDEEEQKDTRLRLEEKMERNRLKAEKRAAKKEAPAPILLPEFITVANLAMAIKIRYEDLATKMKQLGFEEIYPDFILNSENSGLIAMEYKFEPIPDKTEDMDLKPRDPHPNPTELPLRPPIVTIMGHVDHGKTTLLDYLRKSSVAASEHGGITQHIGAFSVRMPTGKMITFLDTPGHAAFLNMRQRGAYVTDIVVLVVAADDGVKPQTMEAIKHAKAAKVPIIVAINKIDKPDINIDKVKLDLARHGVEIEDFGGDTQVVCVSGQTGEGIDKFEETVMALAEILDMRAEVDCPTEGWILEASVKSLGKVATILVRRGTLRPGQVLVAGTTWSRVRVMRNEMGTEISEAGPGFPVEIDGWRDQPIPGDETLQAEDEIKAKRVVDYRIERKERDKLAADMEAINRTRDNLRQQKVLANIAREAEEDEENIGIHQNPPADLSKQKKKSERPSIVYFIVKGDVSGSIEAIKDQISLLKTKEVEPVVLRSGVGKVSKFDIEHAGAAKGYVVSFNQSVSPDIYHLAEGSKVRIFENNIIYALVDSIRTELSNYLPPIISHFVLGEAEIAQIYLINFKGRKRDPIAGCKVRNGLIKRNCKVRVIRQGKNIFEGELSSLKTGKKDVQQVSKGNECGLAFTGGWSEFEVGDLIQHYEERSEKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX59</accession>
    <name>A0A0B1NX59_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003406">
        <property type="protein sequence ID" value="KHJ30962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031263_0_0_1"/>
    <dbReference type="OMA" id="FELCDKA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="673" mass="77075" checksum="C74DAE5B71C8FDB1" modified="2015-03-04" version="1">MSDTTKAESTSITGSQKQTQIQVNDFIKAKIEEFKTLNFKDDNLWEAYQDEFSDFCINDFKAASNSILRSLRIFLRSRGVWVKWERNTTLVTSLYNTLKETSPTEWTSEEVNNSNEVFDSVKIFHIAKTQKASLKAASKLPAQQAQTTSNTQPTISQENESSNRKTHQSYGYGKELSILSKLYDNDLKYHGDNDNFDFKLSIFFELCDKAEIPEQVYGKAFSTMLSGAALQHYYTTSSNSFRRDFETLVNATRDHFEGPEIRRRRTARWESLTLQKIIDENQGKEKSMDDCFTLLLNELRHLQLSLDKEFRTEKVLHTKLINSCRNISACQLACFKPSNTLTGLISDLQSSIAISDENIKDQSSQFFTDRKYHINSQSINQNKHKSNYQSTSKRRCYVCEKPNCHSKYHSKSEQDEARKKFKRRFVKRFDNMIHQYLANLEGDIVMDKEQSDSELDEKIDALVLDISDDKYNTYEESDNSETFMTSFGPIEDPKEIVLKLADRSFSHAINKDVKIITSSNTDYAITYTTWARYNSDHFYGILIDTGASKYSTAGYKQFQAYNKISPSEVDKSKAGAINVQFGIGSSKSIGSTKIHTPIGLIEFHIVQADTPFLLSLSDMDKLKVFYDNIKNKLVTPSGQIPVQRRXXXXXXXXXXXXXXGGNSSKNLFLTRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXA3</accession>
    <name>A0A0B1NXA3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003877">
        <property type="protein sequence ID" value="KHJ30613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXA3"/>
    <dbReference type="STRING" id="52586.A0A0B1NXA3"/>
    <dbReference type="HOGENOM" id="CLU_010344_1_0_1"/>
    <dbReference type="OMA" id="NFQRFYR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115002" checksum="2086D1383CEFF46B" modified="2015-03-04" version="1">MTTRYEADVKSLNMELRPSISTSKPRFCYTLKELLRLRESLPLVKCNICTLSKIPDIASIFRLPDEVFRNPHHYVYHTKALTKFANEQRINYINKEIISQISEDGDAKMPATIDTNIHSPQKALWNLRRRGSNDKSDEPYSAPSGIIAQKTENFQKFYRAVVSPTHVRVTAGGRIVPNTKPTETSGLNLGSEKFNPNSANLDSVPASLKATTWPQFQPVQTRYPVVFNTGVSTPYNILQPGNLNNFSAQSNLNPSTDWNPAERSQIFNNSVNTSMRSRESFLPQGIKISHPSQFDQTKPFVLNGQLLYPLRTGPQVPTHAFSMPNGMLGGASSILQGHPSIFQQAPTPTALGNMTNSVAFPYFSQPPLKNLQFGQNIDLGLTSPYNLATGVSIPPVEILINQLRTLSNILNNLEIQKESKNSQCDGRFLEAECNSIKSQVNSIKSVLALHFPDELKAENKDLNDESLPNSDFHTNHVGPEIATSDQKAAASKTEIEAQESGSFEENSRTAIQANSYIKSRLSISSAKAPPFQPRSQTTIKSLSKKESNQKMPNIQPAEIFSHGSKKSNIKVLKGSIKLKNENLDSVGSPFIQSPTNKFKSIPPLSTHDNSKTSGMSYIGPNTKSLEAPYLIGTFPNGSQYNPSRPFDVVYSRPLNDEEIHARYLYFGKVPRNSQSGLPKFDGKDFYPPSPSKKNPSLKSSHPEINAPSKCDLNTATSYSPRKVAEAYTSKTNSPIRSSRSLQNLNSKSQSFLDSNNDDYSSISLQISKSPQGKGMFKSHTFRSTKNVNRAEANKIADCFMKDDRIEIQSSSNKQEPDQILQKDVSISFQPSNSLRNQSKESRIFYDQDLVHTEHVNLKSKASLASLGKVESHKINPKIKIQISPKMEVFSSNTGKLFTGRVESFHSANQQTLFLQNLLKRNTHILPLLGSALSAAINSENARGYLPQYRGSAIASFFPMKLPNNISGVEVKCLVDKKSKIHQIDGLPSCGASAIDSNNLKLNADQRLSHPAFAIGPVASSYMRTLTQRELGKHTGFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXI3</accession>
    <name>A0A0B1NXI3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003760">
        <property type="protein sequence ID" value="KHJ30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXI3"/>
    <dbReference type="STRING" id="52586.A0A0B1NXI3"/>
    <dbReference type="HOGENOM" id="CLU_010392_1_2_1"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="781" mass="85895" checksum="38032D7EF516AEC3" modified="2015-03-04" version="1">MEFLKSAVASAISKGSSFPYSFGDQVDLGTGIWTLFNGTKREDGSKCSIFSFDINNNKQSLSLARNAVKRLRTLRHPKIIKVLDTIENDSYIYVATERVIPLSWHVKRKSLSIETIKWGLFSIAQTIKFINSEAASIHGAIRLQSIFTSESGEWKVGGLEVVSCVKDDNAIIFSHGNLLSDSDRYTPPEISSSGWDIIKKNPLTAVDAYDFGILISEVFGDHSPGGNQTVQGANIPISMQESYRKLTNKNPKARISVSDFLDQGTRQGGFFTTPLIALTEALEHLGMKSEEEKKECLDELDRLSDDFPVDYVKMKVLPELLNCIEFSGGGPRILGIVVNISKKLSGDEFDQKITPTIVKLFGRPDRAIRVCLLDSLPVLIDKIPQKVVNDKIFPQMITGFTDAAPVVREQSIKAILTIIEKLSDKSINGELLKYLAKTSNDEQPGIRTNTTICLGRIYKNLSVRTRAKVLIAAFTRSLRDPFVHARNAALMALAVTSEVFSEEDSANKILPALCPCLIDKEIIVRAQANKTIDIYFKKLQKFAASMPDSALPPPTTDSSAVIPRMATPQSSEPATWTGWAISSFTNKISEVAGEIIASTAQSSSVVSSVPKNIYGNPESLVPSVVQPNFTLGGNTSNNSKLGKTPENSTIESLQKRVKDINENENDDDRENNEIFFDFSPTKSHAEENQNDKYEDKDDEPDFAGWLAAQAGKKFTAKPLPKGLARSISAPKVSLNSSKSNTLSTNTTTRTMTNKSASRVVVSKKIDTTPNENEDDSWGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ17</accession>
    <name>A0A0B1NZ17_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003113">
        <property type="protein sequence ID" value="KHJ31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ17"/>
    <dbReference type="HOGENOM" id="CLU_1416138_0_0_1"/>
    <dbReference type="OrthoDB" id="5403157at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21728" checksum="88E712293596EA02" modified="2015-03-04" version="1">MSSHIAPRIITSPSSPAIPPHHVSTHHQTLYTQDSLGIPLGKYYPSNYKYVVSTTIAPVPDQIKSLTMINPETGLWFNKRGTKKKNWLKSHDQKATELTMKLQQYQREMIAQARNVAKERKPSLRKLPERVMLHPIETGYDRITPFELAGTEASGYITEGERRRFESQQGVVSGGSKSVDDIKEKLIKIIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZI9</accession>
    <name>A0A0B1NZI9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005705">
        <property type="protein sequence ID" value="KHJ30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZI9"/>
    <dbReference type="STRING" id="52586.A0A0B1NZI9"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="OMA" id="HFICERI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="27571" checksum="28269A93AA592693" modified="2015-03-04" version="1">MYAMILTRPEIAFILGRLSQFMKDPAAHHGIALKDLLRYLRSTVKQKLRFGPGEAHQECFAIYTDADWATTKSDRKSISGGICVLYGGPISWSSKKQNFVATSSAEVEYISQAAYTKQGQWIAQILRDLRMPKIIDKNGLTVQMYGDNQGALALVKNPHLHERSKHIDVSYHFIRDLAEKRKLIIDYIPTSEMTADGLTKPLQKVAFERLKNQLEVIDITAGKVEIFTFTRCQCKRPACSAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZJ2</accession>
    <name>A0A0B1NZJ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZJ2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZJ2"/>
    <dbReference type="HOGENOM" id="CLU_024327_2_1_1"/>
    <dbReference type="OMA" id="YNDFFEM"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="505" mass="58588" checksum="A8092CF5169384B1" modified="2015-03-04" version="1">MGFVHKAIKWIPRVPEPDNYYDFKKKTSTISRISFFRRPLRLRGDSSISVPLGVVLMFPCIVVVVILVLIVRHPKSGVGILMPAGAPPAIRKISEEHDKVFVKGCLEPDTSQPRANAAFVVLARNKELDGVIQSVKSIERHFNRWYHYPYVFLNDKEFNSTFKETVANYTSSPIEFGTIDPKMWGFPDWIDPKVAREGIAKQGDAAIMYGGMESYHAMCRFYSGFFYKHELLKKYEWYWRLEPEIKYFCDITYDPFLKMIEANKTYGFTIAVKELKETVPNIFRYASAYKRVNNLTSQGLWEMFIEPQPDEMKQPSEDDPNQKLPLPEEILRGDPSRASLPEIDAEAMEGEKYNMCHFWSNFEIAKLSWFRSREYEDFFQMMDRSGGFWMERWGDAPIHSLAAGALLAPRDIHYFRDFGYRHTTIQHCPANAPARQMPRPPFLEKTTLDEKKRREEDEYWESWDPVKENGVGCRCRCDTDIVDVEGKQGSCLAEWVDVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM3</accession>
    <name>A0A0B1NZM3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002588">
        <property type="protein sequence ID" value="KHJ31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZM3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZM3"/>
    <dbReference type="HOGENOM" id="CLU_2160281_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="12672" checksum="444A4DFB8B2D6DDA" modified="2015-03-04" version="1">MTFTRCMQSKTRAQPLEQLELRMGIAEQEIYLFGHPPQKPSPPQGQGREDRRVMIRLRKDHEVRKTDSFLLRQQIQKLIPDPTLVSDAWHAPSGITILAPSPAKAAAILQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZM5</accession>
    <name>A0A0B1NZM5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rna binding effector protein scp160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004126">
        <property type="protein sequence ID" value="KHJ30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZM5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZM5"/>
    <dbReference type="HOGENOM" id="CLU_003293_0_0_1"/>
    <dbReference type="OMA" id="WGPNMKP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="317"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="413"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="734"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="801"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="898"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126277" checksum="900D7A994F0575C7" modified="2015-03-04" version="1">MTPVTEFHSSTTGLSNADILMLRHQKAQNPNIQNIHDDNTSYNSLQSNPKLGSRENTTDIPRNSDKFPSLESNVAGKQNLISLSTNESQWVDPHFEELFPGLGDGNAKALSTPIWRANQPNSNMQTQLNYANDNISPNQNGASNRVGSNSAPKTLPPSLAGRIQAPILVLQSNDILPRNQLKKPIPDTLKDINRKLRTNLTVMTGEGGILQFRESSNQKEAVKQQAIKELGTLLGAKKLTTIPIPRSTRAFIIGKQGTTIKALQESTGARIKLPKVDENSALTYDDDEMVDVTLEGNSVAIQLAHTEINKIVRERSVNIQSKLRNIPAEFNAFISGKEDSNVCALEQAFNVQIQVPSYNFWTTQPPPSKPPTGHLPTFLPPNGDDLITITGDRADVQSARAKIEEISDKLRQELTIDNFMVNNSQHQFVIGKQGVSPEYFFSKTGCSIILPSDSNEDSVTVVGHQDHIENAIDYAIDLASSMNQTLIDISKLYRNSSGSSRLHARNITMYLHDRNEIERICNSYKIHIATPLDPDGASPWEVFYRSENSRIATKAQSEIGSIILAHPPSRMATIPVDPFFYDYLRREISQRVKRDFGVYTVIPKKNSSNVDILLVYEGNSEIDSEYQIPREKPNAEMIKHFEKALTDAQGYILSILSKQAQITETSIDVPRIFHEKLRRYIQREQKERAIDEIPVRVFVSGTRLTMRGPQPAVEALSTKVHTFVAQAIEDEKERDFILKFNFPQKFANQLIGKGGSNIKDLKEKFDVEISINDGFVELKGPKAKSEAAKSHINSLARQWADEVTYVLKIDPCFHREIIGAQGTQINRLQTRYKVQIYFPRSAKPAKDDITNAENSSDAGRRVSNRSQQPDEVIIKGPKKGADETREEILSLFQYLRDNSYTATVSIQAGQIPSLIGQRGSGIEEIRQISTAKIEVPNVKDIKDTSTRVEVQIKGTKSSVAQAKKLIEEKKTLFDNTVVKTLEINKEHHRALIGPQGSILRDIILKAGGPDDRRELRRLVQFPKSDSDENIIKVEGPSEVVDKIIAAMQNIVLDRESRITESVEVPIENHRSLIGHNGQIKRDLEQTFNVSLEIPRQGSGLSIIKICGLPPNVEKAKARITELITARKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZQ7</accession>
    <name>A0A0B1NZQ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ran binding protein in the microtubule-organising centre</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005336">
        <property type="protein sequence ID" value="KHJ30069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZQ7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZQ7"/>
    <dbReference type="HOGENOM" id="CLU_073203_0_0_1"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27108" checksum="EC2753BFE303211D" modified="2015-03-04" version="1">MLQASSTADMVSPAHSFHKRVEEVKPSKSDINKLILDYLTKEGYPLAAAKFSKEANLQPYQDDELIHARHSIIHSIHSGDVQKAINTINELDPEVLDRNPSLHFDLLRLHLVELIRNCNSNPGGDITPALAFAAEELAPRAPSNDSFMEDLEKTMTLLVFPSDKLEPDLVVLLEPSLRRKVAEKVNMAILGRQKSQKEATIRKLIRLRAWAEDSARSHNIDLPHQINLDLTGNTVKTAGEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZY7</accession>
    <name>A0A0B1NZY7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004752">
        <property type="protein sequence ID" value="KHJ30216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZY7"/>
    <dbReference type="HOGENOM" id="CLU_1379046_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="198" mass="23135" checksum="E7A8A61A879159FA" modified="2015-03-04" version="1">MKMKISLFIIANLLYTTLSLWIILPKFDVDCYGKDYYTSEMIADVLEPGCVKQSQMRRSKLRKFKPTRKLFSAKTFHDKDNPSKSIYEWNAWIKRYYPNRVTTFYHNRHFLRNPDLKIIFEYRENEDVCIPLYVFAIDRSGKKTRCTNIVNSWATFDYPSLIPVHAAKSEEIEVNDYSAGQRGHAAPLSPQSSGSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P002</accession>
    <name>A0A0B1P002_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tubulin-specific chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002784">
        <property type="protein sequence ID" value="KHJ31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P002"/>
    <dbReference type="HOGENOM" id="CLU_003043_3_0_1"/>
    <dbReference type="OMA" id="TWHERYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="467"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1349" mass="152997" checksum="FC11C46FC95185F7" modified="2015-03-04" version="1">MDITDVEPDVKLQHDATELISELNASLHPMLWKTNVSGKKVLRASVRDRDLSKLLNIIDTFQELPQLLDPHLQKFISLLADSLLTYLQSPPATFSKNNALPLVPTCIAACRLLYRFCKVRGEKVIVKFMSTEVRHIEIVLSALEERASKRKEINTGDEIWQANNENVLCWEETYVLLLWLSQLILAPFDLVSISSDTSSSSYFKVKDLTLPSDSPKIAIRIVPLAIHCLFLPSKEKDAAKCLLARFSLRKDMQSNGTTTSLIKWSLSQLRPDPQIVTHHYLGLLSFISAILSLSIGTSDMERHIFAIFEKVQQLSSSDNQSKALNGNAVARKLIIKILRSIALISFQRPKDRLCFQMIENIIGYMLEVVSDLATPIRLAASKALSVITLKLPEEMCDEVINSILSELKENLLWVEMGRFCRPNYSEEDSMREYLKLSANIPNEGLTTDYAKTNWVEIEKVRSLDLSRVNALAWHGVMMTLSYLVYKRSIKSSNLSSAISALRLGLLFEQRSISGNSVGTFVRDAACFGIWSLARRYTTEELQKVVIKRENEFSPLSVVPKSTLQILALDLLISATLDPAGNIRRGASAALQELIGRHPNIIEKGIELVQIVDYHAIALRIRAIEVVALEASSLSDQYETAIVEKLLSWLGIRNPDKFVRRVVAKVLGQLIWAKQCRTGQLHNESLIFQSIDRIVSEILLLKPRQADERHGLILTLNEIIKNILAHTSKESLEKELDSVQLVFKGSIETALCERKCQELPYIEITPKQSPFLFLIRTLLRDIISILTQFNLYQASYRALKLTFEAVGQLLISAFQLAKIDLIFRELENKRSITQTNHTIINDHAQKLSSHLLQVLDIHYSLSIIQQTRAENHYNAILTAYRLTNGPSKTFMKLAKDTLDHLLESSDRDLSNIISIAAADYGLLCGPNNRWFLEWNTKAFKGDITGQNDQCTAFIYTMFRFPISLYDLWNNASESFACTINRIWSKIRNCDIRVMIIRYLSISFAIREFLLDYSNLIEAGLDDYTTTYQGDVGSLVRIESIKTVAIICEHYLVQDYSNIQKEMTVIFEKLVPRLLRLAAERLDRVRTEAKKSLVFISSLRCKSFQIFSRLTSLSVSSKTYYQCLLEIQCEQYPPHIYQYLFNRYMSGYVTSADGGSEDVISASRSALVDFISGSSKISSDLMDQSFIDINNYNSKDSYIFSALLQVISLKSQRIYVSALEILAFLISLGTFDRQILLNGICILDKVDKILAKSADNIKQIEASIKVFGAFLMAGTNCHPIYDTLILIRKRAICSLTQFLIHQYPKIRNIAADEIFFRTGCGKGIDWTSEIRISEMKLIRQSLSDAKAIEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P029</accession>
    <name>A0A0B1P029_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g4507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01002421">
        <property type="protein sequence ID" value="KHJ31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P029"/>
    <dbReference type="STRING" id="52586.A0A0B1P029"/>
    <dbReference type="HOGENOM" id="CLU_003041_13_0_1"/>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="151"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="381"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="685" mass="76376" checksum="56FE7EB25FD212F7" modified="2015-03-04" version="1">MPEKFDGSEGFLELEEVDGVEVLREGNFLKFITSTAIKKVSDDEFSGFSDDNKNENLDLGNQAPKSRDIPKEHGNKRNVSKVESKNLKDKKRNLNIEDDSLKIQSFRPLLEVSQKEVDVKAWAELNLTSNMLTALSKLGFSKPTPIQSTAIPEILDGHDVIGKASTGSGKTLAFSIPIVESWIESNRDLDDQLRVKQKSATAIVLSPTRELAHQITKHLNALCNELSSAPHIVSVTGGLSIQKQQRLLSKADIIIATPGRLLDTLNSCQQTLEATRLIKFLVIDEADRLLSDGHFKEMEEILNLLDPSGRPDESENIITSRQTLVFSATFQKTLQQKLIGRNKRISEDINDYMQHLMKKLKFREENPKFIDVNPVSQIANNLKEGIVECKGTEKDLYLYAILLHYPNKRTLIFTNSIHSVRRLTPLLQNLGLDAQALHSQMAQKARMRAIERFSSSKPTNPILIATDVAARGLDIKDVQLVVHYHLPRAADIYVHRSGRTARQNSSGTSILICAPEEVTGMRRLIVKVHAESLISENKSKSKYYMKSLDIDRTIVSRLKSRVTIAKKIADSTLAKQKSGHDEEWLKNAAEELGVVYDSDEFEAVSGGGKGRGNGRRLREKEVRSLSNSELQALKDELKHLLTHRVNVGISEKYLAGTGNVNVNELLSGAKGNFLGTADEIIIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0K8</accession>
    <name>A0A0B1P0K8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004449">
        <property type="protein sequence ID" value="KHJ30339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0K8"/>
    <dbReference type="HOGENOM" id="CLU_1732842_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059282" evidence="1">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="17096" checksum="7E977B8B8E2EBBF6" modified="2015-03-04" version="1">MHFYTSESLFILLLLFLSSSLTIKAAPPNNQGLIIESVDCRHRIYPTEKVYNAVIDGLVALAEARALGLDSTDAVNISKRRDQFFPDVPLYEFVFWNSGPNIYQADEKDVVVFTGSGKLMNVFSYYRTPNKWNMRLAAWEIEYCSLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P7</accession>
    <name>A0A0B1P0P7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002237">
        <property type="protein sequence ID" value="KHJ32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P7"/>
    <dbReference type="HOGENOM" id="CLU_2741936_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="71" mass="8074" checksum="93A86CF81D5A0790" modified="2015-03-04" version="1">MFPPVDNSTLKNNPKFSSLYSVLTEGILNSNGTSKYYPGQKERIQVTAVSIYPLPNQLLEKVEYVPPRHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0R5</accession>
    <name>A0A0B1P0R5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002576">
        <property type="protein sequence ID" value="KHJ31793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0R5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0R5"/>
    <dbReference type="HOGENOM" id="CLU_175760_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="107" mass="12235" checksum="ECE0EEA038A36ED6" modified="2015-03-04" version="1">MMCSSQGKKNQQLNFSNKLRAEGIILAPVGPFEESDTREIDDLIGRGVFQFERYNPVEHAGCRLFNSRMVREVKGINYKPYEKSRLVIQGHSDNENKTILIHSPTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V2</accession>
    <name>A0A0B1P0V2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pachytene checkpoint component pch2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0V2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0V2"/>
    <dbReference type="HOGENOM" id="CLU_028208_1_0_1"/>
    <dbReference type="OMA" id="FLFTSNM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="489" mass="55648" checksum="5AB1BD1A3E074FBE" modified="2015-03-04" version="1">MSEAKGVIFIEARIRDDKINDADIDCISYEKLQAELEHQLSSENITFELLEDILDDTQNGEHKLGSLYQQAKDLLSSLKVVEYMGPAREFSCYTTEDVRVEVQIYSLYNSPDFNAEESQQLPQAEIISLPHVRLVFQDDIKDDLIWVVTNLLKFSRLGEIGEMNPLILLYGPPGSGKTSLCRGLAQKASIRLNTIYTQTRFIQIKTATLLSKYYSESARQVDEIFTKITQICTQNPDEFICVLIDEVESIASSREFSIKSGESQDSLRATNALLTGLDRTKMNSNVIFLFTSNMYEALDIAFIDRCGLKCSINPPTIVSQYEILRTKIQKLMRCGMIEVTHPIEAIPVYDEAILAYTAGHTHNPGCQLLDIVHLIRSTNIDPKFKKEFSGRSITQLPEQAILRYLRFEKCDLNLALTYITKFIMFEQDQGKKKVAVHDLGVKINMERKRKFRLILDDICDSQAADKYRKAILSLSLSTSLKIQIEECDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P199</accession>
    <name>A0A0B1P199_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P199"/>
    <dbReference type="STRING" id="52586.A0A0B1P199"/>
    <dbReference type="HOGENOM" id="CLU_061028_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="25664" checksum="7A62FBF6241BF9D7" modified="2015-03-04" version="1">MLSGQAHLYYYSKIAKLTLDFNGASQMLRYQYETEQPQQKDFSEWSTITLSGTLNQNSDKSLDQYFELMLDNLQNLQLRLAPIYHTQKALRDKIMYACRSIPEFCLACFSPIPILEGVCNQLRSSILIAIELPRKPFINQKSNLLVYFFTDRRYHGVKNNSGSFKYSNQQEKPKKCFVCKQPGCWSSKHSKHEREISYENFRKGIQQRGRKTDDTMINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F7</accession>
    <name>A0A0B1P1F7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative diphthamide biosynthesis protein 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002365">
        <property type="protein sequence ID" value="KHJ32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1F7"/>
    <dbReference type="HOGENOM" id="CLU_076154_1_0_1"/>
    <dbReference type="OMA" id="KGHKHEL"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="18836" checksum="616BCF70670B6E3F" modified="2015-03-04" version="1">MAKSQELINLAKSLPPKLSRFFARYPPLSIIPPNYRKDSSPQPKYRFINPFKATRDPNTNRWHDPTFSLRRQADLVKLAREHGVEDLLPYTVKGTKAKIRRKMKHGSRIKGTGAGQNVKGKESERTMKARLEMRKQAMLAMPQMIKTWKERGHGRGWKSWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1M7</accession>
    <name>A0A0B1P1M7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcription-silencing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003134">
        <property type="protein sequence ID" value="KHJ31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1M7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1M7"/>
    <dbReference type="HOGENOM" id="CLU_029547_1_0_1"/>
    <dbReference type="OMA" id="RFYPTHR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="367"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="67014" checksum="7CC57FDD7EDC6699" modified="2015-03-04" version="1">MNDKPDEKGNVNYYRRLSESDAKAVDWRRKIGGMLMNILGGRAHAGASFRNLFTWASADLNKDRNYILTELPDGYVLWEHIKYNKNKGLDVKKKEKGKHAAGMYDRQDAYLYGHPQGRKKRYRSPADFFPHLLWLGTDKEGDSANCSCKICSPDGDDDTVDESITLRAEEIQTKKEPKLLPSSSTITPRFIVSTTQSVSNQISSASPTKATIHLPPKKMSEEQKADYQPTPINKFIYRPGELVWFNNGSNWRLGVVSKRSFKINFPPRYLIQPLSNPEQYQELRIKEQDALRPWLAWSVPETTNPDLKNMHYDAVPWDRVVRGEFDNGRTPDYVVDSSILAAKNIDASYSLFDRIENAVVGNGDIAYNGMFLGAEKIWAGEPVRLSGYGSDIVILIIDRMIERTGNPPNVLFTGDEYKLVEMPSHSRTSDWPKYSHNLPPRMITDIAFRNEVAARKGIWYEWRLTATPATKTLKDVKGRWYETQTLLPILKTPPKYQADLLLGLTSDAGEWMNGRKDNNNFPDQRQKNRRSTLGRSVPDDFKVSRGLDGAPEDDVFPDEQTLIPSLATEFENIDHFMDLDQALYGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Q3</accession>
    <name>A0A0B1P1Q3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arm repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002272">
        <property type="protein sequence ID" value="KHJ32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Q3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Q3"/>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="350"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1256" mass="143938" checksum="E943992A46220F4C" modified="2015-03-04" version="1">MHPAYGHEMQSENQNSHSLGAQNDDDIRVISRIQEALHIAHDSSSTKEARNEAYAFLDQIKCHNQAPGHGFMLASDATQQPTVRHYALSLLEYAVKYKWREYSEVQETTLRGWVIHLARSILPSDPVYLRNKVAQLWVEVAKRSWCSSWKDMNEQLILFWNMPVTEQKEFVLYIIENLSEDVFGKEDIATIMRGDTLQKACTEIFAPSIANSEAFSNQENNCPISSGDEGWLIRIGKFFDYLLDNRLYEASENMKCIVRILSVYKSVSTWIFPAAISNSSCVNKMIKALTVSKIDIQMASVEAFHSLYSRLHMTNEEFTSLVCPILTENVVDLLRRLFDWSCVDPHNIDEEKYQFSKKFSEMISSLGILIEKKILVIPKDCDLPNLFNLFFTITRSESFLVSIPTLPLWTKLLQSDKILELSAINLLIAPLLELVSTRLIRYDVLKDDSEDPSMIFLFEDIDTVPERHTFLGNYRLYIVQIIEIIVYKKHSEAIHHILSQAELSLRYLFDTRTEISVENYSKYSLPALKVDAQFTMIEAALRGYIKWRSVTEPKTQEDEQNRVNVENYMEAWCERILSLKFEDPIIRKRLLQASVIFSTSALDQNNSFMLKVLEQILTNRVLESPEHLKYTEAVKEMQLDCLIELQRLALKMPDQLLDVYDQLESIVNEIIASGTTDIRSQVAFQAFLFTIIHRNSRLKPEVCCEKLHNFIKPVQAVWQDTSLDQTLSSFDQFSQVLGMDKVKKYLIARKAHQIEDWSLHQLDEEGHVIKQEIEDRSKILPLRTTKNFLQCSTDRLDLSSPKLQIARSLWKSSIPIILPKLLSFLRYAHAFHNPENWTGLPPEMATVVNRILSDRFWQAGISEGSKEDFYASVSGTRSTMEGLASTIRGCVRSIRENTYGIFQYLSRFDSDFYGYNELPGPLAHSLFVDAHFLSSHQIINLLQVVRLLIDDCPVELRAHFIPPLLATCYRQIDLKCTTQWEKLTVRQNAATIGQNLTDEMKQESLLRQVTHAAVMMIGTFLDPSRANFPNPKDCSTLGLSTNTSFPSMRMFCLSSPGVVEPILTFLSHAIEMRDTRSCGVALRIFRSIIPEFSQKKDKLNEKENTEILASIREFICHNVLMACISSLNEPYFVDLQRDIVNCIVSILVYYCEESTTPRQVLLKIPKVGEEAVNKCLQNIINPTIQARHQRALVLDLLNDIKGVSISEQGRLSKPPASSCRRERSKMHQAFMSSTTATVKSNGSPILESIANLFNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P201</accession>
    <name>A0A0B1P201_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003001">
        <property type="protein sequence ID" value="KHJ31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P201"/>
    <dbReference type="STRING" id="52586.A0A0B1P201"/>
    <dbReference type="HOGENOM" id="CLU_021051_0_0_1"/>
    <dbReference type="OMA" id="DANWICW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="239"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="426" mass="49487" checksum="7B6471C9E6BD736F" modified="2015-03-04" version="1">MWIWTWLIFKRPQWDAKRVERRRVRVIKDVKKVPISEKTASKEEENSKKSADDTNLLPSENSNKETYEYFWQSYPDDLRERISWVLDLLLNYRGPGWDWSVPIVRTLTPETLSKLENPPKDEANSKNSSAPRKCNNSSCEIIREIFLLIFCYLLLDVLWVLMMQDPYFKFGPTTYELPSHLKNLNPYVLYLYRLTLTGTIIITSMRTGYAIFNNFVIHVLGSKVLGLRGEPWYYNQVWGDFSNVFDRGLGGLWGNFWHQTFRNFFTAPTSYLLKKGYIKPGKFTTKLTGLAFAFILSGLLHYASMFTVFGDAYPSNEILFFGLQGVGVAIQSSLSKAFSPLIVKLPARIRQIGNFIFTLAWFYLTGWLESDNVGRSGVLLIPLVPFSPLIYFGLGEPDANWICWESFNYMWYTGKNWFDSGFFIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P220</accession>
    <name>A0A0B1P220_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002967">
        <property type="protein sequence ID" value="KHJ31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P220"/>
    <dbReference type="STRING" id="52586.A0A0B1P220"/>
    <dbReference type="HOGENOM" id="CLU_003853_0_0_1"/>
    <dbReference type="OMA" id="GQLKQWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1274" mass="140820" checksum="C4A07CA11EFF38D8" modified="2015-03-04" version="1">MSQTTEEAKAEMRARLQSHMTPLAIQRYRAQNLDPLLIWCRQHAAGKLSSERNRLAQQQSQISQSGQGLAMTSMQTPQSLQPNQIIGPATPLNPENVNSDYANFLGTVDSAAHKQQQGVIAQAEGQILVPANSGSKIPSNQPISMTGLPLNVNEQRTSTNTGVRAQPQQNFNPHQIQNQRLQHAQVPQQPQSNVRINTPSTPTTTKSQKIGLHGQPGGVRPGSVPQQSIPSSISTLNAPMKTPQMNQSGLPCNNSNSQLANSLDPRFLPGNQTQSIPPNVSNVAPKIFSEQTALQSEKLNEAINKWSSTPISGVRGPLTTVGTSLGTGQQMRQQAQLSGNFMSNQLAMASLGPRAPNVPATMTPQQALLQQQIANLRANPNNVTHRVFPPNMLVFDNQKLMQIDNAEIPPALLSHPNMPKGFPPEVTKWSDLKNWALTNTNTVGPQSLETIKNFQRLHLQNIMQRNRLIQQARQKVIANQASTNQITTPTPGITAPIAPMGPTQNSKPMMVNVNLDRLRQPTMADIQKLRNHHSGKMRNATDDQIRNFLLRSQQYHQQQQQMNSANNQIIGNQIPQSNNLTQSPSKVKELVHAQKNTGSIPKIPGKPMQASKTMQPILQVGYESATQNSPRGLNSSTVLHQPPPNSTTQSQNSSPAQAVTKNLKRTSNGDLKEEMSSISSLQPTTPQTSLKSFNNASRTPTQKTGSLTSQQLALLTPEQRKKYENALQQSQMNRNSFKLDDQVKIVQEQISKEALTSKVKSMDNKIKDQVQKTLISLIQPTQGMCRALNKWFMKCGDVDRLKTFFRVRARLAMQFQDGKFEQDKIKNVFTISLSEIDFAKKTLNLMITDLRENFPCTKRLEQPKVQSVNPSQGPRLQSPANLQQQKAQLVQGTNSKGSQATSVPISNQTSFVIGTTSPHGTPSYPDKKKVNMELRIPARKKLKLANDPPTNSQNSTVTSISSPNVSNVILTSDLGSKSTELTQPSFFCSELGCDQTIGFEKESDLKQHMLDEHIRPNENPAKHAQDMFALALGLNNEGQNEDVECVSQNSISEITEVKMRPSNSQQENSQLHKASLINSDATPVLQQVSANQSNQSNEISLKDIAKATETKEVPTSKEIATKESVQIAHQETSKTQDSWASNYVHPIDLIQLVKPYENSVNGCMSDLNSFREATPDDTPESSKDGISEPNSDISDGVGLDLQVDLYPHSYMPFGLSDNNILSDEFLLHDENEINMKSYDKDQLPIVYQSFDDINLSTYEKRFSLDTHLFSFDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2B4</accession>
    <name>A0A0B1P2B4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribosome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002084">
        <property type="protein sequence ID" value="KHJ32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2B4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2B4"/>
    <dbReference type="HOGENOM" id="CLU_026936_2_0_1"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="33"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="437" mass="50165" checksum="17CE5B46D1181D89" modified="2015-03-04" version="1">MARRRIKKRTHIGANNGNNSKHTSGNTTNNPKSMVIRIGAGEIGPSVSQLVKDVRQMMEPDTAARLKERRSNRLRDYLSMSGPLGVTHLMLFSRSELGNTNLRIAITPRGPTLHFHVENYSLCKDIRKALRHPKGKGKEFITAPLLVMNNFKSSTDEANTDGKIPKHLEALVTTIFQSLFKPILPQSTPLSSIKRVMLLDREPVDSQNEAYILNLRHYAITTKSVGLSKPLRRLKTAEKLISSRKSMQSDKKNPPNLGKFADIADYLIRDEDDGFLTEATSGSEIDTDAVVEIAETRAKILSKRQKERNKKDEKKRQTTNYVEKRGVRLVELGPRMRLRMIKVEEGACNGKIMWHEYIHKSKEEIKALDQKWEKRRKEKEERKKIQRENIERKKKAISGNVEGVDEMELDHEEWDSDDYLNDDEEEEAEEEDDLKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H2</accession>
    <name>A0A0B1P2H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphatidylinositol-bisphosphate-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003553">
        <property type="protein sequence ID" value="KHJ30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2H2"/>
    <dbReference type="HOGENOM" id="CLU_025895_0_0_1"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="389" mass="42515" checksum="CE8C068034C221CF" modified="2015-03-04" version="1">MNTRSAIENSKIPTALSVAFNQDASCFSVGQESGFCVFDSDPCRIRVSRDFGAGIGIVQMVGKSNFIGMVGGGKQPKFSQNKVVVWDDAKKKVVLQIHTPTVALGVRISKTHIVVVLQNTVRAYKFQTPLKLWHAFETTDNFQGLCCLDSNTLAFPGRTSGQVQLVDLTTGSVSIIPAHGSSLRALVLSQNGQIVATASETGTLIRIFATQSCARIAELRRGVDQAVIFSLAISPSGRLLAAISDKSTLHIFDIPNSYKSSPIIDISTCNQNPAGNPRKFLGETKEENEVNNKKWGFLGKIPMLPRMFSDNYSFASAQFEIADEDKNCLPNTQSKSKSPQRVIGWVDDETIIVIGAGSNSKWEKFIIGKNVDGRRYCVRDGWKNYLIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S5</accession>
    <name>A0A0B1P2S5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003398">
        <property type="protein sequence ID" value="KHJ30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2S5"/>
    <dbReference type="HOGENOM" id="CLU_000288_72_2_1"/>
    <dbReference type="OMA" id="FAMCFDQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="51640" checksum="76BEB0484A616485" modified="2015-03-04" version="1">MSILTTSNSITEPTLSNSIPKSPDKIEIDNEECAHFEKLLQSNRSLTKLLFQGGFNDDKFPTIPEEMADAIRLRNGYGNCTQLPPTLAVMVGATSKKEGAKTTESKSTSTSLTLAKASVKKQNLQSSSLVRKEKLGITAQKPEWHAPWKLARVISGHLGWVRALAVEPDNQWFVSGAGDRTIKIWDLATGQLRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLSLHPTLDVLVTGGRDGVARVWDMRTRSNIHVLSGHKGTVSELKCQEADPQVITSSLDSTVRLWDLAAGKTMGVLTHHKKGVRALTIHPKEFTFATGSTGSIKQWKCPEGAFMQNFDGHNSIINTLAVNEDNVLFSGGDNGSMSFWDWKTGHRYQALDTTAQPGSLDAEAGLMSSTFDRTGLRLICGEADKTIKIWKQDELATPESHPLEWKPTLRRQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S6</accession>
    <name>A0A0B1P2S6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003115">
        <property type="protein sequence ID" value="KHJ31216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2S6"/>
    <dbReference type="HOGENOM" id="CLU_977257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="285" mass="31493" checksum="337C782A2DA47B15" modified="2015-03-04" version="1">MLSYLYLFPNRRQFDIVVTDHTSCIRPNDTKFLCRTKTTAASINAKTKLAVKAKILAATSSIAKKRTDVASIAKKTTSIASTNPSLKSTPPPKATVSAIDTSKLSKSQPRSKILNEVGKQAGNSGKIWNRENGKPSKRSLESNSSKTHKPKPQASADSQIKSKVIKPSSESYKKNHNSINSANEKRLPSSPQAGLKVQSPIAQTNFETSFQELEKFQATKNVTKSKPLPPNYKYTKRKVTMAIVALPIVIVTSWVLFERLWLGKERKELVPPGMSQVQESRENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S8</accession>
    <name>A0A0B1P2S8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001683">
        <property type="protein sequence ID" value="KHJ32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2S8"/>
    <dbReference type="HOGENOM" id="CLU_023476_0_0_1"/>
    <dbReference type="OMA" id="LQGMHIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="543" mass="61287" checksum="4FC02230AF2B5620" modified="2015-03-04" version="1">MGMGPTSITPEHLSFDQLSPSSLTAPNSLTSSCHPPLSRSLSTTSTGSMLSAKTSSTGRDSLGSTTSYSDTSVFRSSTSSSKLKARKSFDVSEKQSRRGFVRPQGTNFAASARSRESVLSLGSIAHLQYYFARTGLLDGRGGRRARKKAEKDNLEFPESLLSFGTINISSDLDSSCISNGSPPTSPQPKESTNSSYLGEVEDENEDEESFFSSEDEEDLQYMLPPTVSTYNHREKYIPRLPTLEELKEELEKTLLDAKTVLDEIKSDLSSITQSPISKESNQVSEDEKSRKKHQNWHEIQGLHILDVMTLAIRAAKMYYTAHDQPDRLAAIKTEREIRSDLLSVMEVLRNMATRNFAFGVKIDEHKLMEQWVASVYDILCREEILIEAERSQWASWTWLDDNWNGSTEEREWAFLKSMDPDSGNLPPFRSVDSLKDTELPSEFLADLMTGLRLVKIHNAVVRKSKRPFGAIGRWHTDFRKPYRCTENLRFWIKAAELRFEVVLDVDVTSIVHGANRKAWKDFEVAILTWCSIARSEITMSLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3B5</accession>
    <name>A0A0B1P3B5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6059</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002895">
        <property type="protein sequence ID" value="KHJ31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3B5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3B5"/>
    <dbReference type="HOGENOM" id="CLU_049768_1_3_1"/>
    <dbReference type="OMA" id="VAHAIME"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="83"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="264" mass="29836" checksum="7E1F25C4AE738D82" modified="2015-03-04" version="1">MKRTTTSAHKSDGFQRKKRKHSFVKPARDPRDEPSPENVEPGSTAVRSPSPFIDFDGLSRPSRGTRERKEECAVKAGTRLQKIANAVRTIIECLGEDPDREGLLQTPERYAKAMLYFTQGYQENVKDIVNDAIFHEGHNELVIVKDIEIFSLCEHHMVPFTGKMHIGYIPNKDVIGISKLPRIADMFSRRLQIQERLTTDVAHAIMEILKPQGVAVVMESSHLCMVMRGVQKTSATTITSCVLGCLEKRDKTRNEFFSLVGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3P4</accession>
    <name>A0A0B1P3P4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dna pantothenate metabolism flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002442">
        <property type="protein sequence ID" value="KHJ31965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3P4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3P4"/>
    <dbReference type="HOGENOM" id="CLU_042326_1_1_1"/>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990143">
        <property type="term" value="C:CoA-synthesizing protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990181">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pantothenate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="42151" checksum="B73DAD682B51333E" modified="2015-03-04" version="1">MKQPMVPENAEQDYFNSNPPPVALDEHKALAQNFINAHAASGNRLVLITSGGTIVPLEKRTVRFIDNFSAGTRGATSAEYFLEAGYAVIFLHRQFSLLPYSRHYSHATHCFLDFLHEGPDGKIIANEEYREEMLMVIRKYNEAKEKKMLLTIPFVTVTDYLFTLRSVSQLMRPLAASGLLYLAAAVSDFFIPSERMPEHKIQSTGAVEMLSAIGANSSKTVEKEDFDNFDSSPEVPRSKRLIVDLDPLPKFLKKLVEEWAPEGMIVSFKLETDPDILIQKAQYSLERYQHHLVIGNLLATRKSEVVFVAPGQEHRWIRTDSTSANIEALNGEEKNQKLQSQNKSEIEKLIIPAIVELHDIHVERNKFLQSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3S4</accession>
    <name>A0A0B1P3S4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative trafficking pga2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002742">
        <property type="protein sequence ID" value="KHJ31601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3S4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3S4"/>
    <dbReference type="HOGENOM" id="CLU_121099_1_1_1"/>
    <dbReference type="OMA" id="RWGYSAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="157" mass="17816" checksum="1B501ABEA2AB1E22" modified="2015-03-04" version="1">MSNTIPSFVRQGGDNFVRNVTGMWDGMRPRDYIRIVVIVGAYLLIRPYLLKLAAKVQAKEFAKHNPSICIPSEKGKLSPNDLRDGSQMKVKNDDAENESLGIVSGSGWGEKARRRQSKNETTNSKLNERQKSDLKDEKKNVNILEYLVDYEEGKEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3W8</accession>
    <name>A0A0B1P3W8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002389">
        <property type="protein sequence ID" value="KHJ32040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3W8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3W8"/>
    <dbReference type="HOGENOM" id="CLU_601579_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="455" mass="51514" checksum="F659034D96D12A5F" modified="2015-03-04" version="1">MTSKSKLHGGNNIMHTAGIFSDMTVDGPDIGTLVVVVDRAKNLPDRKIIGKQNPYCAARLGKEAKKTDTDHRGGQTPKWDQELRYTVHDSPDYYQLKVSVFNDDKKTDLIGETRIDLREIIVPGGGQNDFWHNLNCKGKYAGEIRVEITYYDTRQKQEKPEAFKPGALKMTDLEASINEVQRETKQHKNLIKRRPLPSDPVIRESSPGMSATSSFPYNPELETVDHISKTCAYTASPSPIYEHSSTDYRRYQNQNSVARYEGRHNSFPRDQLRTPNSGSGYAKSPSYGFQAVSSTEDYERVQATRREFQDSGYFSPQLPYSCRENNLSGYFSLHGNNIGRLNTNSNSPEAQKIVSNSASQRSLNGHHNYPETRAPQSESRDNFYPREKSGSSYIPYTKPYDYPCPEDLGAPPSLSDSPPPPPIHRSTNSNKYRVSLDHTSVPYVVSEFTQKQFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X4</accession>
    <name>A0A0B1P3X4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002385">
        <property type="protein sequence ID" value="KHJ32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3X4"/>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="OMA" id="SEMTHVA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="272"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="415"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="647" mass="71272" checksum="7B077A593A6D2FC5" modified="2015-03-04" version="1">MQKQRRLRPAVMNGIPEGKDFANLLGYPRHAEHTGRLHRHRVGGEGIQRTYKYTLAMRTCSLLRAVTRASSISICPPVLKSALRLKRFSTKCINRNISFSPVDPSKLDEISTLSNGVRVATEALPGHFSGIGVFIDAGSRFENENLRGVSHIIDRLAFKSTQNRSSDEMLQVMESLGGNINCASSRESLMYQCATFNSAVPNAVAIMAETIRDPLIKESEIQEQLETAAYEIGEIWSKPDLILPELVHTAAYKGNTLGNPLLCPKERLSCINKGVIEAYRKFFFQPERIVLAFAGVEHYEALKLVENYFGDIPITHINQSSIGLQTFDSPLTHNQINLPHPSSSQVQFNASSSQISSSTPSILAQTSTKIAPRATFYNYLSTWAADSPVQIPDFPSPLDSLQPSHYTGGFLSLPNLPPPTNPSFPALTHIHLAFESLPISSEDIYALATIQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQHGWVESCVAFNHSYTDSGLFGISASCVPAYVPQMLDVMCRELHALTLENGPYCLQNVEVKRAKNQLRSSLLMNLESRMVELEDLGRQVQVHGKKISLKEMCHSIDRLTISDLRRVAKLVFGGMVKNLGCGSGAPTVVLQECADQGTEKEFKWETIQDLIASWNLGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P488</accession>
    <name>A0A0B1P488_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002627">
        <property type="protein sequence ID" value="KHJ31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P488"/>
    <dbReference type="STRING" id="52586.A0A0B1P488"/>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="16765" checksum="11783D7F120F503D" modified="2015-03-04" version="1">MPTRLTKTRKHRGHVSAGYGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRYFHKQGNHFWKPVINLEKLWSLVPAEKRDAYLASSNSDTVPVLDLLPLGYSKVLGKGRLPKVPIVVRARWFSKEAERKITEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P497</accession>
    <name>A0A0B1P497_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002283">
        <property type="protein sequence ID" value="KHJ32155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P497"/>
    <dbReference type="STRING" id="52586.A0A0B1P497"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OMA" id="CWLAGYM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="555" mass="60707" checksum="4E37B6E3565E7636" modified="2015-03-04" version="1">MMNTSFYDDTNSLCEIKTIEENNMIEDEMLSPDDQLLAQLGYRPELKREFSYLTVFGQSFGSMGIAPAIAESIAFSLGSAGTVGMVWTYLVGCILLIPVSLSLGELGSSMPTSGGLYYWVARLSPPKPRAFFCWLAGYMNTLGYISIYASTIYAATLILGATISISVNGGYTPTKYHNFGIFLATILLTFAMTCVRTSVLNKLNLFYLYLQLGMLIALIVILAVFTDSEKKNTPSFVFLEFQNTGAWSSNFWAFMMAFLTPVWVVSGFESAATIAEEASNAAKAVPFAMVSSLVTATFTGWAVIVTIAFCMGTDVIGIVTTELGQPLAQIAFNSLGKSGSVGILIMLWFCSICNCSILMVAASRETFAFARDHGIPGSTFLRVLSAGAVPARAVGFVAVCGAFEGLLMLVNTIAINSIFNLAIMGLYFAYCMPLILRLVYDNFKPGVWYMGDKLSYASALYSVIWMTFIFILLLFPSYPNPTRDEMNYAVVVLGSVLVFCVCYYWCPKIGGRYFFTGPLRTIDELIITDQQGLVGGGNYQLNPAQNIEMKLSQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4P7</accession>
    <name>A0A0B1P4P7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ph response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4P7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4P7"/>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="OMA" id="CLHGYAK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="319"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="680" mass="76178" checksum="F1D67F2A5C1F1FF2" modified="2015-03-04" version="1">MKSHSMPISLSSPSSATSRKLFNRLSYLTLIRARPRNQTEFYIRPDEPHRKYSPGDAVKGTVVLTVFKPTRITHLTVCLHGYVRVFKSPNGANEPFVDPGLAATQNPQNSQYFGNGHASLFQDEITLCGEGRLDAGIYEFKFELLFPPKDLPTSIDFERGTISYLITATITRPTLINATNSCDRKISLVEKVDVGHMLPPKPRIISLTPIIPKAKRSRESCKREKHDVEDQMNRRSRLISTATCSHHDDSVSSCGSVDNQTDRPVGQVNTESSEIRNINSPDNRVASLAESNREGSLRAGNIDLHTSNSNYNSSKRQIGDQTITAKIELQKSGCLPGDIIPLKIHLKHKKVIRSMHGVIITLYRQGRIDSAPFQHPSPQKNAKEAARLKHEEYYPKSKTGLSGLSLTSAGSCSIFRKDLAQTFAPIVIDPKTFTAIINTSIKVPEHVFPTIHGVPGQIVTFKYNIEVCLDLGGKLASQQRYLPLLGKFALPSSSNYLNKIKCLDNDSNKISSWGCSIVGTESIRREKNVVTSVFEITVGSEDSTRYWKSKVENSAQIPESFQTGEIEYVPPVGEDLPIIIEQDMIYDQQSREDYIYTQDDLRNQYIGCYSYNQVADYRNFKTTYLPISNDSMYIPPPNFHMDDDLSEKERARRAEERLLPSSPPIDAININSIAVVPVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4R6</accession>
    <name>A0A0B1P4R6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002200">
        <property type="protein sequence ID" value="KHJ32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4R6"/>
    <dbReference type="HOGENOM" id="CLU_1262349_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="219" mass="25158" checksum="B5557187FBA6BD71" modified="2015-03-04" version="1">MADQTDVRHKSKGKRSESPLLHHESLKEKWLDGIDISSSPTELADYISLKCDEYTFTESTDEDLHELVQLDFQKWDSTIFNKVRLPTLQRFRNLLRQHGIYVRKTKVSCSIAIAEALNSQYREWAKSEVEEIIKDKTFSYVSGKLQYIKGQIQTQNTFSSTLPTPSMIPTPMNIDTPSPKQFCRSINSNQTIPNVAPHESKHLNFNPNPSNLQTFKPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V9</accession>
    <name>A0A0B1P4V9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative sorting nexin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0901</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002139">
        <property type="protein sequence ID" value="KHJ32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4V9"/>
    <dbReference type="HOGENOM" id="CLU_014571_2_0_1"/>
    <dbReference type="OMA" id="LWETFLM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="168"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="65478" checksum="F7D8424C14967BA0" modified="2015-03-04" version="1">MDLGEALESPWQDVPSSANPCKIPENSSQDKSTADNPIPKTNRPEVSNPLKSSSIGGRNTRSIPRRLQIKPITVDDSLGPLGPLGEVTSITQSVDQPPAPPKKEESSNVNHQAQQIQQNKIIYDITGLHDDTKFIQSPRIPPPVQSPPTDTLKRDTRPSVSIEQAAKPSFEISVGDPHKVGDLTSSHTVYQVRTKTTSKAYHKSEFEVTRRYRDFLWLHNSLHANNPGIVVPPPPEKQAVGRFEQNFVESRRAALERMLNKIAAHPALQHDADLKIFLESESFNMDIKHKERKEPLGESKGMFGGFGIAVGGGGKFVEQDDWFHDRRIYLDALENQLKALFKAMDVVINHRKGLAEAAGDFSMSLYALSTVEISPSLAGPLGGLSDLQIRIKELYDRQAQQDVLTLVITIDEYIRLIGSIKQAFAQRQKAFASWHLAEQEMHKKKALQEKLMRQGKSQQDRLVQINAGVSDAEKKVHQARLLFEDMGRLMRSELDRFEREKVEDFKSAIETFLEGAIEAQKELIEIWETFLMQLDAEEDEGAFYKPPVERAAQPIPQPTGDGSHNSDPQEDSLLPSINTGIESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Y7</accession>
    <name>A0A0B1P4Y7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001255">
        <property type="protein sequence ID" value="KHJ33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P4Y7"/>
    <dbReference type="HOGENOM" id="CLU_002756_1_0_1"/>
    <dbReference type="OMA" id="RARMSYG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1496" mass="169638" checksum="D9E503761FAE4B00" modified="2015-03-04" version="1">MATPVRNLISPSCLSHIPIDQLSPSLELTASLSIKAVVTLTWPYSSATDSISFLFSEPDFRKRNSRGQVRVEFSGNSGKNVVKAGVSSGDLVVLSLEGVEWIRDDSSSVFPGRGIEFKLRFTDKILLQFQRDGSKELQEVRVDHLLEEDLSLDSNRIDSETKFASQCTPGSLSGKLDQSDLGKIFIGNNLYSSPAFLKRARTSYGSLFDSDLDTFIEADGTVQGKGRKKSRLSLTWGYRSPSPYLEEKEDKGDVSVEVLENIPNQVKPFMVDEGVQTNEHGFSEILNLTLPVAEPIDKANKDTSVSTMDEGIQTTRFSNLGPTESVHKNLLISPHNSPVPSENLKQYPKSSMAEQYSIYGNSGSVNTQVQVKRIPPSPIFCIDDDKNKLNDSERNPIVQEKEKLQNFPTYSIPAEVETSHFTQHLTTIKGEGTSDLSSYSPLYSKNTIKIQPNSSQPIKSALEPQDVEKITKQNIGVEEIGVIDANLNSVLGKHNEVPTKSLNASRVVESEHDMTVSSTDNKFSGDNFGSEYRSNLVELSYSSPRSAIPKSESERLTLSANLIEEDENYESLSIKTCQSLSYNKISLESNDETRTLPSISENNLSSPFYQGSENEVLEEQSYMYQSFTGNEYKDNEKSYKYCSQIEKENNSEKNALLSGTFEEFRRERDNDPLSENEIYHMNNELPKYIDLISSDDEEGTSAPVKIISDRISSSSVFRNSKISKDSKDKEYEKDADAIMKLQEIKDLMDVEDLKIREKVQEIKDEQGPGVMKVMTDSEDLEDVEAQKLKDEEELKDVEDTEEEEELEDMEDVEEVGDMEGVEGVEGVEAQKIKDEEELKDVEDVEGVEVVEDMEEVEDAEGVKVVEDMEEVEDVEGVEAQKIKDEEELKDMEDTEEEEELEDMKDVEDMEDVEGVKVVEDMEEVEDVEGVEAQKIKDEEELKDMEDTEEEEELEDMEDVEEVGDMEGVEGVEAQKIKDEEELKDVXVEGVEAQKIKDEEELEDVEDVKNVKNVEVVEEELDKENMEDMEGVKDLEDVEAQKLKDVEELKDLEDTEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDVEDVEEEDDVDDVDDVNHMDDKEDVEEMKEVQEIKDVEEEQDKDNVDAEEKEELTLCEDQVETTRRFQKEDSRLCISTEKQHNLGKVHFQQFETQDPSIVYEKKLNKTTPMSQAFKFDELSTKEILIVHKESPMSRDISSKDISQANVKQNDWSFDNRKIFTGKEASDQVIASPEKYIPESPEEKSSTNVSHHSEHIYWSTKLSTSSKSPEPDSIVRNSSIKSQQRGIGHDASFEIALSSLGSPSKKQLLPLVDKNIIFAQKLQTELSEYTPLKILSQHLNKKLDVLGIVASSPTIPKRVKGGPRDYVVTFDITDPSIEPVSFTQIQIFRPYQDALPVVEIGDGIILRNFQVLMNKKNCRLKSMKQEGSGWIVVKRNGEVQVKGPPVEYSKAEIEYISELQTWFSELDTITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Z5</accession>
    <name>A0A0B1P4Z5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001505">
        <property type="protein sequence ID" value="KHJ33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Z5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Z5"/>
    <dbReference type="HOGENOM" id="CLU_009823_4_1_1"/>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="519" mass="60153" checksum="7EABCF8D45C1B5FA" modified="2015-03-04" version="1">MDSDDEYMSALSSDEDDVLLDESDDGSADEFGFDEPEPDLELSLKNETPNKKNSFDTSFKVFRPCDIQSQQDELINEVNLILDLRREETAILLRYFKWNKERLIEEYMDRPKKVLEDSGLGQNNSHVPKLEIIPGFMCDICYEDDSDLQSFALKCGHRYCIHCYRHYLSQKILDEGEAARIQCAKEGCKRIMDAKSINILVTPNLKNRYNELLTRTYVEDKEKIRWCPAPDCVNAIECGIKKKDLDKVVPTVTCLCRYRFCFGCGLADHQPAPCELVKKWLKKCEDDSETANWISANTKECPRCNSTIEKNGGCNHMTCRKCKHEFCWMCMGLWSEHGTSWYNCNRFEEKSGSDARDAQTKSRISLERYLHYYNRYANHEQSAKLDKDIFFKTEKKMVQLQSASCMSWIEVQYLNTASQALQSCRQTLKWTYAFAFYLARNNLTEIFEDNQKDLEMAVEALSEMFEKPIVELADLKLKVEIMDKTSYCNKRRLILLADTADNLATGVWAWSDSQPVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5G4</accession>
    <name>A0A0B1P5G4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iq calmodulin-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001970">
        <property type="protein sequence ID" value="KHJ32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5G4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5G4"/>
    <dbReference type="HOGENOM" id="CLU_011914_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="245"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="488" mass="56936" checksum="282C8CE51543E60E" modified="2015-03-04" version="1">MTTQITRSSRHTNGPITSKIDQRHKVTSNPETLHSQQKEKAAIIGCKKRRQKIPTLKEESTVSRKRTKLKAELNKRNPKSSCITLDSKPEEEIQCSTLPSKTNDRSNSFDLNKIDAKTITTAICQKEALKDVNFNKSISENSEKDHKWKLRSRECFRFKSELSAYFPEYDIVIGNKPQDDYVLNVDTPIVIYDSTRRSCPHSPTEKSDHYPLIEFPDTLFADLHNAEKINLTDLIGSFEENPSQDILCESYFKSLHKRPYRAEKTIRNTDRERAQHDRVQVTRLLEGLRGHDWLRLLGVHGVPESKKREYESARQYFIRGCESILAKFQAWRDKEKRQKIERDVTLAAEVKKQQAHIIRKDITEYVDNVTFATKQNLHESIMQVTNALPNLRRKPRSKAVNITQPLEPNQDLTSIDHNPRIQENTLKSLHRPGRIALAWGYPISELPEQEFKLPDEFWDERFLRAHARKKRLVERVKKHENKTPMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5L6</accession>
    <name>A0A0B1P5L6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peroxin 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001937">
        <property type="protein sequence ID" value="KHJ32625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5L6"/>
    <dbReference type="HOGENOM" id="CLU_046457_0_0_1"/>
    <dbReference type="OMA" id="RNDEWEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="424" mass="48657" checksum="ADD195E2643D7677" modified="2015-03-04" version="1">MSSQMKTWPAPPLSTSSKRSTTKISKTYRQASTLFLTRRLPESLTTMLPILEYTPDSLDPPPIYSANKITRIKVWSLYLTILNAICELPPDEGKQNFGNFEFRALVSKVRDGTIWDEVIKNGYGGLEGNVDTEVVINLATLLLAHSRSQKINQLRLESYLSSRSEAKNNQAEKYQNHSRRQSIVDSSGGLEPARELNSLVKVLELYTLHVLLRNNEWDFAREVITVSSILDEDRREAFLEALSTLQAEQREIQQKDQEEQRLRDEKLRRDAEELLKLNRDIEQKREEETKLKRLMRYKVTEPDCATESTSKLCQNPSITSQNKQTTPKKSSLHPTTHSNKAAAPPKSAPISLYNRSQIILRNIYDLISTSAGNIKMQPLLMLKIMAFVCSLFYVFRKRDLRYKMMSSWVKFKQTAAMAGKVSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5P8</accession>
    <name>A0A0B1P5P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001910">
        <property type="protein sequence ID" value="KHJ32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5P8"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="107" mass="11685" checksum="7740ECF6067BECCA" modified="2015-03-04" version="1">MKVDVKAPTKCRNCGGPQRSDSRNCLARPSRSGPVTKDQLKTIRQMGQREYHAEARAKAAIIRAEAAAINEETPSICPKNNLDFISTNEVDMSEASIDVGTSPEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T6</accession>
    <name>A0A0B1P5T6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative rna binding protein nrd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001309">
        <property type="protein sequence ID" value="KHJ33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5T6"/>
    <dbReference type="HOGENOM" id="CLU_016577_0_0_1"/>
    <dbReference type="OMA" id="GIVQTCI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="488"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="679"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="730" mass="79430" checksum="687F1B9078926B0A" modified="2015-03-04" version="1">MSTAVAELDAALQAMLGLKPPGVSGTRISSLTSLCNENVQCESVLIQKIFTHFKKAPGTHKLGVLYVVDSVTRKWTEQAKLAGQTINSTAHDGTFAAGVHRVKELLPVLMNDIIHTAPNDQKEKIRKLIDIWEKGQTFPLSMLNTFKEKLNTQDGPSLTSTTPPGSPPPDLQNRIGLLNATNPAAPAASDTSAILAALAKMARQNTTVASTSTPVITATPSTPAIPSVPATAAHYQSQDNSYNVPNVHNIPLRQPTASNQTFPPPFPPINPQVAQGTFPSIPNSSSNNVPSFSNQTNTFPTAPPVVPNTAGLDPAVQQQLLLIKALSDQGFTPDKIAGIISAVGNRVTVPPTLPINSQSQSLPVGQGNQNTWGMKIEESRDRDGYEPPRSPSNRFRRRSRSRSPQAWNNRDSPLRRREEPSLDYERGSPHTRGDDRNRSRGRTIDYRQRSPPRRLPSPSPPRNFSNPGNKWIGYDNTIPKGSIKVLSRTLFVGGVTGTEQELRQLFSRYGQVQTCVVNRDKRHAFVKMVSRADAVTAKDAMEKTRMPESSLRTRWGVGFGPRDCSDYATGVSVIPISKLTDADRKWMLSAAYGGSGGAPIESGMIVEEPDIEIGQGVSSKAISRRMQTDRGGNNGPKSSRDRDDSDHRRTGREPGKDEFGRDLRDEDRKDQTQSISGPPSMPAVPPFGMLPPGFPFSLPTQQNAMNMFPPGFNFLGQQVTPAQPPPPGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5T9</accession>
    <name>A0A0B1P5T9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mif4g domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001077">
        <property type="protein sequence ID" value="KHJ34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5T9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5T9"/>
    <dbReference type="HOGENOM" id="CLU_002633_1_1_1"/>
    <dbReference type="OMA" id="DFQHHQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="479"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="683"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1217" mass="139262" checksum="FFE7FA5D19B731B7" modified="2015-03-04" version="1">MERKRKRELRELNARAWNGEKGIFEVETSLDSSLKKNTAFIKRLRTAISPATLSIFLHEIRTLILHKYLSEIISACYEGLCKLKSPGEIEAGIEIVSALHQRFGPVEFTEYLGWLVGKGLATPDKSMIKNLPIEARDREEKERSSRQRVLLRVVTELWLTGVLRTLDDVSRPEDIPSGKESLSTGLGKTIEVKPKPLNGERGISTEPFPLEVLKDLLSHDKEHTNLPLLVIFIKSFGWDVLGIKTKSDNQKGVEEDATSRVTNGTEADEDSVESLMPAENTSEDPPLASLEIQELFRNVLRRYFKELKTHLIRDQKAISKQAQKDAEAYVKSGQVFEDRQASFEKIQKSYERLASNAQYLADILSEPMPDLKENDDSQTSANIGIGLVKTGEYLRGEGDCSSIWADEDEMRFYENLVDLKGKVPGVLLEDAKKKKNNVDELIGKKPESNDLAVDSRSTEIKEEDSCTTIPNKTIGVQVDLLLARLPDLISKELVDQAAIDFCFLNSKASRNRLLRAVQEIPKGRSDLLPFYSRLVATLGKYMPDITKGLVDHLDHEFRSLQRRKEKEFLGQARLINIRYLAELTKFGVVPEHVIFYCLKVGLDDFSRMNIEIICSLLENCGQYLLRNLETSPRMISFLEILKRKKAVQHIGQQERMLIENAIYYVDPPVRAAIEQKERTPIDLFIRKLIYLDMNSRNYAKILKHIRRLHWEESEVVTILEKIFSKPGKVKYGNIHLLAILASTLFRYHQDFVTTIIDNLLEYIVLGLEQNDFKFNQRRLAEVKYLGELYNFRMVDHPVIFDTLYRIMTFGHGGPPIPGKLTPYDMPDDFFRIRLIATILETCGVFFNRGASGKKLDYFLSFLQYYIYTKDPLPMDIEFIVQDLFALTRPNWKIASNLEEASKAFQLAMIQDQKISSTNKCVEPEEPDSDGNLTGEIGNHNVENESSKQDRDNSDSDDEDIESSGNNIPSHSTDSEEEDIVVTRQEDVFDPEDEADFEREYAKMMSESLESRKHERKSAFDVPLPMKRKEIVNNNDLWINDSISNKNSPAGTMVFSLLTKRGNRQQTRTVALPSDSTLAIAMKSQQQAEREEQQRIKNLVLNYDLCDGDDQEGIEKINTKDYTRLDKSSNNRSGQRARKLQLSDVDWYDSQRNSFPSIEQVTLTNVDEKVPLSRNRQGRATLSIADQCLKRGSPRLTKKAIFESHRAWTFEEKTDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P616</accession>
    <name>A0A0B1P616_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pwi domain mrna processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001835">
        <property type="protein sequence ID" value="KHJ32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P616"/>
    <dbReference type="STRING" id="52586.A0A0B1P616"/>
    <dbReference type="HOGENOM" id="CLU_032410_4_0_1"/>
    <dbReference type="OMA" id="KICMDRV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="528" mass="61432" checksum="131D15867611D4CA" modified="2015-03-04" version="1">MACSVDAKLLKTTKFPPEFNQKVDMEKVNAEVIKKWIASKISEILGNDDDVVIELCFNLIEGSRYPDIKKTQIQLTGFLDKDTASFCKELWKLCLSAQTNPQGVPKELLEAKKLELIQEKIEAGRTAEEARKRKEEQLRREKDLNNTKNRNNELEDRGKRSARGDSWRSRHSERDFDRRKIDRHSGRNNTRGFDRRSRRYSKSPPRRRNSRDRGTFRPTRKLDTYIPHRRTNRRRLSTSRSRSRSRSRSRSRSSSLTRSRSRSVNGRRGRSSSISRSPTPHRKSRSQPRRAENYRGRSERYGRGRSPGRSPSRRTRRKSPSPSGSFHSRSRSYSRSPKPIKRRRYKSRTPSFSPRRSRRFSSSRSHSSSSSRSPSRYSKGAHSRNSLKNKSSRSPDIDESKASGTRVDSRRHRDSSELHVSKGNNRNKSPIRGRRSPPRSPRKNSHRSRSPSQSRTNGGNVRKRRRSIQYYEPANRRRQNDPSAPLHSDKRESKADFSEVDRRSSNQDSKRSNATMTDISDGVVNHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6D7</accession>
    <name>A0A0B1P6D7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative pyrimidine 5-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002230">
        <property type="protein sequence ID" value="KHJ32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6D7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6D7"/>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="OMA" id="RHHTIDP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="250" mass="29150" checksum="A04C57B88BFEBD5B" modified="2015-03-04" version="1">MADQRPVFFFDIDNCVRIYKNFIPRVGKIFVSLYILTKKFTTGSKVGEHLVALINKYSMDHLHLTKEDAYRLNREYYKTYGLAVEGLVRHHKIDPMDFNKKVDDALPLESILSPNPKLQRLLGDFDKKKVKLWLFTNAYVNHAKRVTRILEVDSFFDGLTFCDYSELKLVCKPDIKSFEKAMSEAGISKFEDCYFVDDSELNCKRAEELGWTAIHLKEDETVASVYGPCKYQIKDLEELRALFPQFMLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G4</accession>
    <name>A0A0B1P6G4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mitosis protein dim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G4"/>
    <dbReference type="HOGENOM" id="CLU_564054_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="484" mass="56207" checksum="78EBC32126467E5B" modified="2015-03-04" version="1">MGSVVLPHLRTGWHVDQAIMSEEERLVVIRFGRDYDPDCMRQDEVLYKIAEVVKNFAVLYVCDLDEVPDFKQMYELYDPMTIMFFYRNKHMMCDFGTGNNNKLNWVLEDKQELIDILEVIYKGAKKGRGLVISPKDYSTRYRADRKAQKIDAEHARKEAYRAEALDKGYRRNDRNVGRVLSSKLSIDQEEFIKLTKAELYAFISKLYEEAINCPDKDEWKAAIISKIKLYFFYMFVFDVKKNEDGEVIKYKAFSVARGFSQKYGINYEEKFAPTIRYNAQRLFLSTAAKNVWKIYQMDTVTAFLAGTLNDKDYLQMPQYLWSTFGKYVRILKSLYGLKQAAAVWYNLLRSFLVENGFHPLPTDPSIFINRSNTAQVSIGVFVDDLLIAGGNENEIFAIKEKLKALFEMKDLGEARNVLGIRIRRNRNLLAIDQSKYALEIVIEFLAKNAAAYDKPMESNALSSLHYEPGMPLDEKLYLRILGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6R7</accession>
    <name>A0A0B1P6R7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tyrosyl-dna phosphodiesterase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001936">
        <property type="protein sequence ID" value="KHJ32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6R7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6R7"/>
    <dbReference type="HOGENOM" id="CLU_007773_2_0_1"/>
    <dbReference type="OMA" id="FPPMDGQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="562" mass="63423" checksum="53E86BA251F045CF" modified="2015-03-04" version="1">MNISYQNTILLNLRLQSIPTDSQILRITGVIIAAKMSGLAGLDRKAMELERLARVSRKRLLETTIDKDDVEIETEEKKRQRITDLSIPNHLCQGLPKTERTNSSIEARYNSKISPLCSSSLSHPINEKIKLGVQYPNGVIKKTWAQGFSRKGDDISIEEVLQKDDLTLAVLSAFQIDTRWILGKLSDKTRVYWVLQAKTDDEKQEWMSQASSMYKFCFPSMRGNIRCMHSKLQLLAHPSHLRIVVPTANLVSYDWGENGIMENMVFLIDLPRLENNQTLALEDLTNFGKELTFFLEAKGLPENVITSLRKFDFSRTNNIGFVHSIGGSHTGSLLNRTGFCGLASTINQLGLKKSDPILIDFITASLGNISPKFIETLYTAAQGTLELPPIKSQNNSSTNKKSALRECVNNFCRIYFPSRKTVESSLGGLGAGGTICFQSRWWSSNHFLQHIIRDCKSRRQGMLMHSKLWFVRSQKPCSQHAWAYIGSANLSESAWGRVSMDKNTKKPRINCANWECGVIFPAKSNHNKVDEEMAEFVDSIPVPMIAPGDSYEGKVPWFFCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B2</accession>
    <name>A0A0B1P7B2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2237</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001557">
        <property type="protein sequence ID" value="KHJ33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7B2"/>
    <dbReference type="HOGENOM" id="CLU_028200_6_2_1"/>
    <dbReference type="OMA" id="WWDDGFL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="56010" checksum="7090B555B5D43DB4" modified="2015-03-04" version="1">MESVGKLPKCCMGCVLPILSDLHCNMGNVTELVICFCSDSKVQKNVSECTGTNCSNRELKHSEELLQVICAGAPKPTMQPQIYSITTITSVVVSIFVALRCYSNYQISKKLWWDDGFLFISTVFFLAFQCLTFWGTSYGFGLHIWTANTNHWHGLLFFEWLWEIIYIIVQTMTKVSVLLLYYRIFPQLWFRRVLFTLIGGMFIHFIVFTAVIVTACRPIRSFWDKTVDGQCLDTRPVGLIGSAFSILEDVVFLCLPIPLIWKLKLQTSRKIGITLILTIGVIACAASIVRLRYLYQYNQTFDQIWENYLIVILSQIELSLSIICVCFPAIRLLFSRNRRENDGSSDSKATSAPSHSCPSVRPHSSSILSKIFSIISNNSLRSSMSMPWISSRAPQLSSIYITSHIELSDKDPSGSNSHIKDYKTHITSSKPQVETLITPLNSALRNVPGIMRVDKFGNLITPVQNLEKAIHQEDNENVSPIADRHNLTPDHIGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7E5</accession>
    <name>A0A0B1P7E5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative chromatin assembly factor 1 subunit a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001000">
        <property type="protein sequence ID" value="KHJ34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7E5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7E5"/>
    <dbReference type="HOGENOM" id="CLU_013392_1_0_1"/>
    <dbReference type="OMA" id="YENVRPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021644">
        <property type="entry name" value="CAF-1_p150_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11600">
        <property type="entry name" value="CAF1A_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 p150 subunit acidic region" evidence="8">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="9">
        <location>
            <begin position="325"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="10">
        <location>
            <begin position="544"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="602" mass="68834" checksum="ABFC5EDCEDC44A04" modified="2015-03-04" version="1">MSLDVPQSSHKRHHESFSENCVIMGDATTASFCLGENNQPEFDISPAVPVFSVETSVSSKSSVLEIDVLNQPPLKKTKLLEHDVKKYHEETKGVGKLEEKARKEKEREIERLRKEAERKKKEADREEKRTAYEIEKLAREEKRRKVEEEKRKKEEERKKKERSQMKLGSFFAAPFSSKTREGLTNMKAQSSLNPPSSIDYVKFEASLASEKSIKPISPYSKLFPDFFIQNGVTLAPSNRSRTDQKSLKQAQENIDECITGSQILEKPPKIRDTLNLPSEKCLPRGRAYRSTRQIMKDFYHERLNSKNVPSIYHASESIFKSIPIKSLKFYEDVRPPYIGTYSCRPIHGIAKLARNPLRKDLPNVDYDYDSEAEWLEDEEGEDLQSDDEEEDIDDVEDIDGFLDDEDDENPRSRQFDLNGDLEPISTGICWEDCEGRNPNVELENYRIEFILDQEIKSIDPLSKSYWPSLVISDIKPNGLKNFCSKSQNHNGAHNPSASKNEDLMMLTATTNQVCDSKQVNLKKLKKKEILTNNPSTKLIAPEDMEEFKTAVVGSDLSKIGLIEVLKKKFPGRPAAAIKATLELIARRGQKGQKEAEKRWALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7L8</accession>
    <name>A0A0B1P7L8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2803</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001899">
        <property type="protein sequence ID" value="KHJ32669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7L8"/>
    <dbReference type="HOGENOM" id="CLU_015741_1_1_1"/>
    <dbReference type="OMA" id="HQPPKEW"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140068">
        <property type="term" value="F:histone crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043993">
        <property type="term" value="F:histone H3K18 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140129">
        <property type="term" value="F:histone H3K56ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140011">
        <property type="term" value="F:histone H4K12ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140046">
        <property type="term" value="F:histone H4K16ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="306"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ32669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="46629" checksum="5AB7FD7DAE6F2B7C" modified="2015-03-04" version="1">MGPIRQNIVKRKAAEEPDFPKENKRIKIEDEKLENKVTKLPAIPFPEKPAVIEEREGEIEFRVVNNDNERESLIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSMAIVKKPLEVVGGITYRPFKGRKFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLEKSVWMGYIKDYEGGTIMQCSMLPRVRYLEIGRMLLKQKEAVHAKIRAFSQGHVVHQPPKEWRDGSWKNGKCKINSLDIPAIRRSGWSPEMDELARQPRHGPNYNQLLHLLNDLQNHNSAWPFLNPVNRDEVADYYEVIKEPMDFSTMEIKLEADNYSSPEEFVRDAKLIFSNCRKYNNETTPYAKCANKVEKFMWAQIKAIPEWSHLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D9</accession>
    <name>A0A0B1P8D9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative uba ts-n domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D9"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D9"/>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="307" mass="34271" checksum="94F5F047DD7215BC" modified="2015-03-04" version="1">MGSTDLENLLEFGYPRNRAQLALKNGGSLQNALDWLNKNESTTMQEQSVVCESNELSTDMTPLKTGEVAKSMVCDDCGKKLRSMMAVQNHNRLSGHENFSESSEEIAPLTEEEKAAKLEELRAKSREKKAQQAIIDKQEQKKNEKIRMKSTKEVQDAKERLAQQEQMKAIAKKRQEKLDDIAAKKRIQERISADKEARRKKAEAQKAEREGQAAPVEPSFTRTMTASSQSTATEARLRLQTSSGTLTKTLPAETTLFELGQQIQAEAGQPVTKFTTTFPRKTFSGTLDFSKTLREAGFVPSAVLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T6</accession>
    <name>A0A0B1P8T6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01001503">
        <property type="protein sequence ID" value="KHJ33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8T6"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="OMA" id="AVHIKAD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="282"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="564"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="821"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="873" mass="97068" checksum="6C32667BD56E80DE" modified="2015-03-04" version="1">MMIDDDIIVNFEINDSPITVKRIFQGGKWRDRFIAKKCAAKRAAKKTSQTSNREIFSKNYLEGAEELVNGENSNAKKRRRSDQGPANPNHIVTDSKKLALYTGEKKEIEKKSDESIACQEKTKAGFISGKLPAGTININGSSKVNHFKKFDSILGQKSTSLAENSSHENITTVIGAKKIVFNEAPLTVQRDDINKKTSLNRDATNVKKGGQIISSLFSFNPTAKTKYEKPEQKAKHNEPSNAPLPSELENFTNLGLSTRLATHLSLKLSLKAPTAIQKAAIPLIIKNDDDAFIQAETGSGKTMAYLLPIVQRIIEISSQGIQLHRDSGLFAIILAPTRELCKQIATVLDKLLRCAPWIVGTTVIGGESKQSEKARIRKGINILIATPGRLLDHLGSTEVLKVDTVRWLVLDEGDRLMELGFEQELKQIVEKLNNKFIMNNVSRALKSDSLPKRRVNILCSATMVMNVQRLGEISLKDAVYIAADPTEKNNPGDTGESTESSMNKFLAPAQLRQAYTIVPAKQRLVTLAAVLKKAFARRGSVMKAIVFISCADSVDFHFYLFSRSIDKLSENEEKPNLPFISTLDEMTKDTVAHGIAISNKSNTVIMHRLHGSLTQNTRTATLKSFSTSTEPCVMFCTDVASRGLDLPNVDYVIEYDPPFCADDHLHRVGRTARAGKDGSALIFLLPGEEEEYISILASGHKEGEKALNFKAADDLLRKGFGGVGKEWEERATNWQLDVERWVQDSPKYLEMARRGFQSQIRAYATHVAGERHIFNITTLHLGHLAKAFALRDKPGNIKVPGIRPVKVSKAERNMKGRKASHKEGEEIAPEGERVRKQRKLDLDLPKTEPDDASIRMRRKVQEHMSAANEFNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P985</accession>
    <name>A0A0B1P985_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001378">
        <property type="protein sequence ID" value="KHJ33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P985"/>
    <dbReference type="STRING" id="52586.A0A0B1P985"/>
    <dbReference type="HOGENOM" id="CLU_015711_1_0_1"/>
    <dbReference type="OMA" id="TQWNVAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="570" mass="63861" checksum="2B09ED4B99973B37" modified="2015-03-04" version="1">MTVNIEADSLSDINQIASNPPSFPRNPAEKPRKPLTLYIARVPGSKDIFLTTLKPYTKNVTAQDVVSSLYYFHVNSDIDNQPSPKSSPKFPGDVSSHTLTRKPLPLRSSNNSSDNELHSTPDFPKAKTFSIRRKPVAGSIPTTSTQHSHADQPTPRQPLGPRNTSSVSVIERKPLPRDDYQNSGLAKTNSHPNNPNHQDNDFSDSNHKSVLESNKSEKAFSVTIIRRDPSSGAQWNIGIISGNPLIEETSDGHFNSRSAKRPYYDISLSLITSGYARFRDKCPIIDQTLQQSSNSDKNLHQECGTTFDRKIKMEGSSFWNRASAQRKRALSDFSDKYRNSCGLRIQENENQRHDTRAHAKGYVFTSPWGGRCKFVTGSGGRSLRCHHKLPSPISANSMDLEQHSIIISELRFNLPISFLSYSTAPQSIGRKVDFFSESQYKDVRNKMKNLKFTGPPLSHRNRSSSSFDLRSRDGRLLARTSSRTSIDSQENIHGNTINTSKNSLETMLQDNKEENVSNKYLDLGREKAGGGSNGKHAKLGKIIIHDEGIKMLDLIVSANMGIWWSVWDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P997</accession>
    <name>A0A0B1P997_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001364">
        <property type="protein sequence ID" value="KHJ33546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P997"/>
    <dbReference type="STRING" id="52586.A0A0B1P997"/>
    <dbReference type="HOGENOM" id="CLU_078556_0_1_1"/>
    <dbReference type="OMA" id="MYVEPSG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080549" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="25398" checksum="3879DFE2BD7C439A" modified="2015-03-04" version="1">MKYIFLLTASLATLVNSAPVDDKATLGDGSVDYGSYGAYGAYGSYGQYDASVGTESQSMAASDAPADAPVAVQNAAPNHFVAVTTRSGDANVHLQPISANGQRFFIGKDTATYCPLSDCSSYVNFTVFLARPYDANSGLGLYTNVAGGQAAFVTKEGELGYTQAHSGSSPSGSLNNPFQYTPGTDPDTTGTLSFNSKGFVACPVADQADVYQIYAVGAPNFSKPDCIGVGITTSTYTGSPAYQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D3</accession>
    <name>A0A0B1P9D3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sec34-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000654">
        <property type="protein sequence ID" value="KHJ34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9D3"/>
    <dbReference type="HOGENOM" id="CLU_1367137_0_0_1"/>
    <dbReference type="OMA" id="PRAFISC"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="23115" checksum="6155AB143D2BB9F9" modified="2015-03-04" version="1">MYDDSWYSFIPNQISTELFDSTHEDSNHDLKESASKQPDDKTCKAESIKSISEIDSKPRAFISCPNVTPIKRSKSYSNFFEAKKLLHHEGTYLSRRSSYVDLSSSTGFSYSSYESFEDDLVEQNLEEYKLYHDHLEMFERHLDKLLVDTNSTLDYLATLSESFRSIDRDTTAFKGKCEDLLADQKRLIILTREIGNALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J8</accession>
    <name>A0A0B1P9J8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001307">
        <property type="protein sequence ID" value="KHJ33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J8"/>
    <dbReference type="HOGENOM" id="CLU_010712_1_0_1"/>
    <dbReference type="OMA" id="MWPYFTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059449" evidence="1">
        <location>
            <begin position="22"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="83"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="311"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="682"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="746" mass="81591" checksum="A856C6F19946EC13" modified="2015-03-04" version="1">MLSWKIFNISTFIALSVFTSAAIVQTPKYVESNTRAVNFPATFGHAIPTALDGNDQPIDTKTKLDGTSTIPAVDRLAESVSNVRSTVLIIARDTASAFSASSGLNGYGIPSEIFVIPKNGGILPALNASSTQGNYGAIFVLSDVRYDYGGSLGIQSALKFEQWNSIFDYQVNFGVRLVRIDALPSDEFGTASTNVGCCDASVEQLISISDTKLFPSAGLKINAGVSTKGLWHYPTQIVDSTIANEFAQFAPAESFSNISTAAVINSFLGRQQMVWFIGFSTEWSATSNFLQHASIHWATRGLYLGYRRLNLNTQVDDMFLISDIYDPAGTTLQIVPSDLEQHVSWAETVNERLPAGSNWFIELGHNGNGNIEAAATVSSISCGIGPIEYDEQVDTPVEWIKPPGTGVNLWPTEPAEYPYGSECTNIDALKAWFSDPKNLNAFAHVSHTFTHEDQNNATYHDVSKEISWNRAWMNQVGIASALRYSDKGIIPPAITGLHNGDALKAWLDNGIVNVVGDNTRSVLLNHVNSMWPLVTTVAENGYDGVIIVPRWATNIYYNCNLPGCTVSEWINTSTGSGDFDTLLANEKETNIRNLLALHRDPFMFHQANLDYGNAEEIEINGVTEKLSLFQAWVETIIQELTRLVTWPVISLKHDDIAAAFTDRMARDLCEPQMSWNTDFVLNTITGVTVTTNKDNKCSVKIPLTVPGDVTDLQGHSTERIGSDPLTIWVDLSGSPVSFTFVSPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N5</accession>
    <name>A0A0B1P9N5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative duf1687 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001488">
        <property type="protein sequence ID" value="KHJ33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N5"/>
    <dbReference type="HOGENOM" id="CLU_126094_0_0_1"/>
    <dbReference type="OMA" id="IVDWNNG"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="156" mass="17991" checksum="A6CA98C3D2196227" modified="2015-03-04" version="1">MFRFHKTLDVITLFHNANSPESRAVYQIMKKASEYATANSSGNNTMRNSRGFERRSQFKLEITEKMPTRDQLRCILDYIQRVPLFKANVIDGRERYVEEVTPVIGAVVKGAKNEFDAFLRMKANPDNFHRPMVVDWSRGRASSVTNELVLMDMIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9T0</accession>
    <name>A0A0B1P9T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000575">
        <property type="protein sequence ID" value="KHJ35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9T0"/>
    <dbReference type="HOGENOM" id="CLU_2456439_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059455" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="89" mass="9715" checksum="6AF1C23455AE9540" modified="2015-03-04" version="1">MLMLKNLFQVAIAIFLGSSLCIQSLALPVDVTEVSDNNPLEPRGALMGAVVGGVGAHLYHKIKNLKEDINEQKEVIKEKEAKIKDKADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA15</accession>
    <name>A0A0B1PA15_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA15"/>
    <dbReference type="STRING" id="52586.A0A0B1PA15"/>
    <dbReference type="HOGENOM" id="CLU_138085_0_0_1"/>
    <dbReference type="OMA" id="EKRCEAD"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="136" mass="15887" checksum="E95308223C5E4130" modified="2015-03-04" version="1">MKHTFSMRPISQFEGQKISLKHPKEIACFSYDDEHQFRLNDSSLKYYYTPSLGADLCKGFEQFQKLDDTADEHLDSLLKTIIDLEQKIGHKVKANLITWRGMMTKLTGAIYDNFDGFEMNATMFQGTMYILHLQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA97</accession>
    <name>A0A0B1PA97_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chromosome transmission fidelity protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000979">
        <property type="protein sequence ID" value="KHJ34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA97"/>
    <dbReference type="STRING" id="52586.A0A0B1PA97"/>
    <dbReference type="HOGENOM" id="CLU_004894_0_0_1"/>
    <dbReference type="OMA" id="RWLKGWE"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="284"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="957" mass="107365" checksum="3A6DB19495D103A9" modified="2015-03-04" version="1">MNIPLTLTSCSDPKTPSSLHKRPQIEVLSEGNKLKKVGGFLIEDLSDDECLSPIEEPPLKRRKQGLSSEIDAPETDKVEYSVCADGESITGILHQILGERKYHTTTPHDSLQVPEIIDINSDQVISGFDDDDDGIAITKITTCAGRTKSIKAQKPATHTSFEELVSARSITKAGQAQKSFYGIPLYQLIEEIKRDTIKDQQLNYSDIPLPSMETPIHYNDSHKTLMWTEKYRAKNFLDLVGDNRTHRQVLRWLKAWDSIVFPTSRKRKQEATAAQKDTDNEKQHRKILLLAGPPGLGKTTLAHVCAKQAGYEIIEINASDERSKNVVNNMIKTSVGTESVKTGSQVKSKSGKSESYTRPLCVIVDEVDGVDGGFIKAIINLCLLDQKNTSISRDGTNNPARKKKKIEKFKFLRPIILICNDVYHSTLRPLRNSNFAEIIHVQKPSISTIVMRMKNIFEKEAIDCDDDAVRRLCEIAWEVNASDSRKGMEGACEGDLRGVLIVGEWAAMKLKANTKNGENLRLTRQWIEQNLSDNMSCTGDEPQGVARGGTREVVNRVFLEGAGFPHVISAKLTNITDDQSQAQLGLTELAKKAGMEKLKMMIESNDINRIILDVFSQYPNKSFNDDSMLSKPDAAYEWLHFYDSCSSQVYLNQNFELTPYLSQPILACHNLFASSTRHSYSVYNKSSARNKEEENEVLIPFTGPRADYDAYEIEKSNRAVLSSLISSFDATSLRNFQNPEKVAIEFLPYLIRMLSPEVKPVIVGDFGGRKPVGSVRRESEKIMVERTVNIMSNFGITFEQGKLESGVTGNATSLVYRMIPPLDDLVFFETANSCAVSRPARYAVRQVLDQEYQKRLAFRANSVKSTKERELHGSRNSSQETQQKDSLVKSLILTDFEKDFFGRIIKKSSSSSKDDSLQGKKSFIGQLGDQRVWVTFHEGFSNAVKKPLSIEHLLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAV1</accession>
    <name>A0A0B1PAV1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative wd g-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001054">
        <property type="protein sequence ID" value="KHJ34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PAV1"/>
    <dbReference type="HOGENOM" id="CLU_000799_1_1_1"/>
    <dbReference type="OMA" id="HPRINGA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052640">
        <property type="entry name" value="Gemin-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46362:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1557"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1672" mass="187968" checksum="40AE4527407AEB91" modified="2015-03-04" version="1">MKEGSQQGKNALNFEPCAATASLFLFAKGALIICVHRDILAIDQVFSNHTEDIRLLTVDTVSEKGAGKWVASYDKGQNAIIWNCMKGEELFRFKSDQKLTTMTWMQNGTAAFGNISGIVILCEPAKDKFLSIPTIDQNPITALATASDSKTFAIGFADGTLVIATLEPKFTIQYDITLSGLSSQISVLAWHSTSSRQKSFMLASQYQNGDLRVWSIAKSNHPRINGAKVVRLLRRSENDPSGLNWLGWSRNGRIVQFLERSVSHNKTWLWDVRTKYVTHEIVSTLEYVKGIAVYGAGATLFILGENYTVQQFDLSSPPHLVNNVQYPDSSLQFSSLSVSRQLRDNLIPSEFSNSDSKQFEPQNNQSSQIIPVRPDSSQSQKSMTSQDSLNLQQKKFTIGSDTSFESKSESNMTHNDSSWLSSQEPSLGSGRATPSLCSNNSRSEISENLPTTRYRLWNRNDFDNSNQLNVHELFPITKNRLNKNLANLKSDVVKSTHFSNQDWTRRLFSIIFDWNGDCRELINDEIKRHSPQSTTRLLLARWLGEVELENTEFYSGSMTLSDWMLLALNGMCRQTSTVRLTQVYVQRLLDCGDYHTAATIMIGIGDSNDAIQVYIHYEKYVEAIILTCLVFPMDKNRQAKLVKEWGEWALNHNQYQLAALCLSLIYSESSEIWCSPITMNAKFCQARSNTQNIPDILSPPLSPPDTRRPMRNIALASTLKLNTSFQNQCGGNSHHSQVIENLVTPIYSALSPAVGETVQTAFFQPGPSSVYQTPVSALTATPKNFKGQNFQIKGDKSGEELCSQQQNENIPCIENFEGKYEATKNESNTSPQVDLDSESKLNEIAATKSPMIQKKNDEFIIPLRPIISSHRSCHDAQSKNSSIEYNQSVGLEIQWPALDSIITGDYINSPNYSRASHRYQIPSPSQSPTITSNYPESLGTNIKYHGHGINRGISKSLDDYISSLELTQNENIGESFSYEKEKNNNFSVLLENQNHSKARDFESSNFIPRNLPKDRHSQDSFNFHNDGKNNTIVLTRKCSYLKHKKLSRRVASCDQLPRLSPDRSLLSIDIERGRIQEREGSKIRAPSTPTWPTQKTFHDEDENDEDLRQYSDNFQPYYSSDKISTQRRKFKLQGPSNAYDSSHDNIEGKLSEESRNRRWPENLRNEETARYFQRELYYDRSPSEAKARGRKIIRDGKVLRKEKAARELEERRKSLAQRPSVPVIIHPEELDRLSPLPQLKSTSKVLPVLKFSELQRSYVNKIPVSAAIMKVRQNCDEKNKEMKMKKTLGVQLGLPATPRALKNLISNTNCNSSSPVQPRTLEKYETPTKQYSRDKSNFLSHHLEKFQKLAPLPKTTYKASKTSITTPIGRIPPRSASAPIPQEPPTSPVALPSDLPTHPAFQASLPPSSYKRSSDEKKVNSSTPLWYMRKVSPGKSNPGTLGYQTRNNQASQNRVITSFMHGIDEIIEATPPPSPPAPPLLKELQHLAGPPPPPPPPPPPPPPPLLPPPPYNLEAPNTNSVVSAISSGSGIIEIIRDDFYDDPFVHDKEKEKKDKRPNISDVCSQSQTGVGHKLKKNDTDVCTPVIIRSSNDISRTPNPIITWVPSSSPLPRRSATASPPSYLVENRSRFFLPNNHDHRHEGHRRCHTNDSRFPMASDPTDITGAVDEGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY5</accession>
    <name>A0A0B1PAY5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative r3h and g-patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001238">
        <property type="protein sequence ID" value="KHJ33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY5"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY5"/>
    <dbReference type="HOGENOM" id="CLU_007254_1_0_1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="544"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="714" mass="80963" checksum="378933277DD4CA30" modified="2015-03-04" version="1">MAHSKNVSRRSNNKSRPYGRGEARKSLVPIAKSSTKPSPSEFTLKDEALSTSSKKRQWYSQRNLRNSRVVFVNAEDSQNDKVENTSEVLISESGAESKEPEQKIITPPLKQQFPRKKSTENLINSFHIGESINIGPFSTQIRSISPTPSSSSDEIILFQGRNPPKASVDALSEKKDIIKEKESENLEESARKSDCSSGHEPLQLSCFSKEILSPKPVKKICTQLLETQLNQSSNVKINLQDESMNDYLANINPKNSNKLIIFSRRDLGGTPDFEYEEPESPIQSIAEYEVFKNVSNIEKKNNPRTFYTSHKPGAQFNSQAGSRKISTAISRSSSMSTSSTSSTSSNNYSINFKHHNFETELLDNPTVKTQDSDDSGDSEKSEYDDTKIDIFTHFYDKKENVKRILTKYGDLGTSSDNETSKSYIQDTYLSRKYFHPPSPSKRKRDKKKKKRGLGKGKKKSVDSYPDYDELDIFDIMDFDRPVVSKKKTALKFPDPTMDEYMKMAVQNNRLKKQEKKKEREILRNLGLLGNKKTKQDLRHKYKTGMDFDELKREVKAFLKDGTSTLVLPPMKKSNRQVVHEMANMLKLKSKSNGIGASRFPVLYRTSRTTQYAEDIFQSMELAFTRGFFPRNNYKFKKYSKNNKFRKNGTKKAAVSYREGEIVGGSAPEISVNNKGRTMLEKMGWSSGTALGALNNKGILQPLSQTVKKSKRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB83</accession>
    <name>A0A0B1PB83_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000187">
        <property type="protein sequence ID" value="KHJ35952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB83"/>
    <dbReference type="STRING" id="52586.A0A0B1PB83"/>
    <dbReference type="HOGENOM" id="CLU_005766_2_0_1"/>
    <dbReference type="OMA" id="DANTNML"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="14">
        <location>
            <begin position="193"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="653" mass="72902" checksum="C94A58F29A340A62" modified="2015-03-04" version="1">MEMLRSDARANFAAAAAAAAAAAARGSADHHRGRISHGNGPKSSVIYDLMEVIVLEDSPLATYLEGEGQNSNHSATFVSRQPESPSLSYAPKGRPILSRFKPHIISSLWLETPRSRVTSAISNLYSRTLDPGLSRADNARFLERFRYLIVASQLLNLQTYPSHTGNKSTDLQVGDKSPSLSLTVAGAGITALFAFLLAWSIHWVRSGANSIIGIGRIIVLFTVVGAFGVIFYAYLQRRWLQRLRHDTLAELSELILAAYNIDNAAASALSLIQEVELVSRGYQIGSPLPPVSRIEDRNQIRLCSRLRRKLRDCFIKVQAKYVQSCRNLQPLAERLDLEKYYDIYDISDIDLSEILSEKPEIEPEELESIRALKILAARYNVIRKFFLCCLMALDANETKNDLHRWNVAMEEIHMIRLTTASAAEELAISLNEDESSPISPTSKTTQLPGRERWRAQSRQLSLLSSGIRGLQAKLQLLKEESDRRLNESEDLSDFGSNLMIQYESLGLDLKGLVQEWEDGKSALSSNLDRNERRISCFSGVVSPTASLGGLTVVEEGGGALDALKALNGEMRSRSSIDFSTSDFEEVFETVAMPLHRGSMSREERIAKMKDDRVKRYSARYSQENNTKILRELESVIRMRPRNSLSVSTRVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBI7</accession>
    <name>A0A0B1PBI7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000154">
        <property type="protein sequence ID" value="KHJ36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBI7"/>
    <dbReference type="HOGENOM" id="CLU_051198_0_0_1"/>
    <dbReference type="OMA" id="YLYAYGH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42971" checksum="85580B8F13242835" modified="2015-03-04" version="1">MYVTPFKTMNSQVQDRKVIWPPKIKLRTPLGYLRDSTGNFYPRDIGRSSILSNGSVLWQFGDTFSHNFRNDFLGVTDNTCSVGSSQNPTLSSYAKASGVPQKDDDYILNNDNASFGDQILKPLLGSFPNFHGPNAKNIKLWPFSGIVEYSRCPEFVRGWSFYELSTYKDGSMDTEIQAVLVADITHQISTGMTKATLAGKGDHILFRANEPRFGSFCIMLGDDEYLYAYGHLTPTKDVGLSRVPIRRAAFREEYWYWNGKNWSQNIEESRPVITTMQHGQVFKTHLFGADSIYKYGFFGCNSFGDSKAILGRGVAPEGPWQMELLDLDIYALNKDKSPFQYCFYPHPWASNERKGDLLVTWSEGGMDGNVIAVQLRFETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBK0</accession>
    <name>A0A0B1PBK0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000964">
        <property type="protein sequence ID" value="KHJ34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBK0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBK0"/>
    <dbReference type="HOGENOM" id="CLU_002227_3_0_1"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="289"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="969" mass="107032" checksum="F3531E9386BA990D" modified="2015-03-04" version="1">MFTFRPLLGAQSESAASQSLLELDGGVKILIDVGWDETFDVEKLKMLEKQVPTLSIILLTHATISHLGAFAHCCKHFPLFSRIPIYATLPVIQLGRTLLQDLYASTPLAGTKIPASTLSEASYSYSQKTSAFLDSEILLPSPTPEEIQTYFGLIHPLKYSQPQQPIPSPLSPPLNGLTITAYNAGHTLGGTIWHIQHGLESIVYAVDWNQARENVLAGAAWLGGAGGGGGEVIEQLRKPTALICSSRGAERSALLGGKAKRDELLLEMIKSAARRGGIILIPSDSSARILELAYLLEHTWRTETKNDSSPLQASRLYVASRNIGATIRYTKSMLEWMDEGIIREFEANAGSNQKQGLSDSGHGTGPFDFKHLRLLERRAQIDRILGETDNLGRSISKVILASDKSLEWGFSREILRKISDDSKNLVIFTERVGRVENEESKPTLARTLWVWWEERKDGLISEGTKNGEILEQVGSGGQVVEFRDAKRIALEGNDLSIYQQWLANQRQLQTTQSEDVLSLETHDASSDSSDSDESETEQQGKALNISATMGQVNRKKIGLSDEDLGVNILLRKKGVHDYDVRGKKGREKMFPLAVRRKRIDDFGELIRAEDFLRAEERDEVTGQEIRSQAGKDDSKDTLGKKRRWDDVSNQRGQLKGNNKRQQNFRGQIGSVNSEELSYGPEDDTLDEEADEDILAPSRLEYLKESVSLQVRLAFVDFAGLHDKRSLQMLIPLIQPRKLILIGGIKEETLSLANDCRKLLAAHTGSSEESTIDVYTPEIGDVIDASVDTNAWAVKLTDSLLSGLKWQNIKGLSIATVTARINASPSEPIETKTEGNNKKPKLPIIENEEVKQGAVVTTSRPTELPILDVLPSNMVSAARSVAQPLQVGDLRLADLRKIMQTSGYKAEFRGEGMLLIDNSVIVRKIATGRIEIESTALSTEFTSTISTTLQQGATFFAVRDRIYQGLAVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN1</accession>
    <name>A0A0B1PBN1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3-carboxymuconate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000144">
        <property type="protein sequence ID" value="KHJ36112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN1"/>
    <dbReference type="HOGENOM" id="CLU_038716_0_0_1"/>
    <dbReference type="OMA" id="NKEFIGY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059513" evidence="2">
        <location>
            <begin position="18"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="41271" checksum="EAB464189101DE7C" modified="2015-03-04" version="1">MIQIILLGFLLIRMAPAVNLYVASYAGKITSLSLAQSRDGEYALSVISSLKSDTPQPSWLEKNGDLVFLVNENFAGPNGTVVPYKTSETGILTPVQQPQITPPGPVSIAVFNKGKALAIAHYGGSSVSTFEVSSDGTLSPLQVFSFKSPPGPNPQQDVSHPHQAILHPTGKFVVVPDLGSDLIRVFSIDEKSHLTEQKSFSVPAGSGPRHGAFVQVGESTSQKTYFYLISELANTVSSFSVSSTEDSLDFTPVSSNDVLDQAPPKGLASAELVISSDKKFVYTSARNAPLLSLPDPSGSTKEQIPSDTLQAWKIDSSSGALSFQQLAPAGGRTPRNFSLNKNGTLVAVALQGDQRIAIFERSIDSGKFGRLLASMAVEGELTSVIWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBP6</accession>
    <name>A0A0B1PBP6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000927">
        <property type="protein sequence ID" value="KHJ34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBP6"/>
    <dbReference type="STRING" id="52586.A0A0B1PBP6"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="OMA" id="VERCDTH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="531" mass="59870" checksum="F9ECFFD7CFE3DEEC" modified="2015-03-04" version="1">MIKEEINANDTQEHKDMALQMAVKAVNDTAGVMGWARIYGAGCLTGYDGIVPTLLVFDTFPRISELDPPSPSIAKRVAALKKAIIEVSKLRASRLVKDALRTRNGPITKDIPLGSDVVIWQKHEKNWTAPYTLIAINEKTATIQFLHRKSQRLIPSLAIYKNFDIFTRDISQAYTQSKSQLLRDFYVRPSTELDLPTNTILKVLRPLYGVPEAGTHWFHTYHNHRLQKLNLKSSSYDPCLMFNSEAIVGLQTDDTITACTHSFKLKEEDELLKVKFGAKPVQILTQNRPLIFNGALISKSDTTIIVSLHDQIAKIAQVKNNCLHDFVSQRARGAYVSSVYQPQVIENPSRGLKFVKLIGKLRIIVFTDSSFASNPDFSSQLGYFIFLVDEDNNYNVIHWSSINFKRITKSVIASELYVMCYGFDIACILKNTIDNILDNKVPIIVCIDSLPFFECLVKLGNTRGKQLMIDITALRQVYEPREIAEVIWIMGETNPADALTKHAGNRALQQIVDTNKVALKPGAWVERCDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC16</accession>
    <name>A0A0B1PC16_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative guanine nucleotide-binding protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000632">
        <property type="protein sequence ID" value="KHJ34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC16"/>
    <dbReference type="STRING" id="52586.A0A0B1PC16"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="355" mass="39251" checksum="C8A8B20C5ADB7045" modified="2015-03-04" version="1">MAIDVSPDQMQARIQQARREAENLKDRIKRKKDELADGTLSGIARSQQEALPKNQMMKTRRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLNSNRDGPTRVARELSGHSGYLSCCRFINDRSILTSSGDMTCLKWDVETGTKVTEFSDHLGDVMSISINPTNQNTFVSGACDAFSKLWDIRAGKSVQTFAGHESDINAIQFFPDGHSFVTGSDDATCRLFDIRADRELNQYGSETILCGITSVATSVSGRLLFAGYDDFECKVWDITRGEKVGSLVGHDNRVSCLGVSNDGMSLCTGSWDSLLKIWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC41</accession>
    <name>A0A0B1PC41_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="JNVN01000623">
        <property type="protein sequence ID" value="KHJ34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC41"/>
    <dbReference type="STRING" id="52586.A0A0B1PC41"/>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="OMA" id="CGGIWAS"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="24446" checksum="D5982FCCBC302360" modified="2015-03-04" version="1">MGTQKCICDHYDYALKSNTAWATYKNNQNPALFEKTKDKQCPKILWIGCADSRVPETTILGLEPGEVFVHRNIANIVAPSDINTMAVIEYAVEKLKVLDIILCGHTRCGGAEAALTDKCVGGVIDHWITPLRTLRRCNASMLEAIEDPIQQGIKLSELGVEMGIHNLLNNYSVREAIKSRGLRIHGCLYDVATGRLKDLSIGTDAIKKLSIEEKQKILTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCA0</accession>
    <name>A0A0B1PCA0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g4761</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="JNVN01000222">
        <property type="protein sequence ID" value="KHJ35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCA0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCA0"/>
    <dbReference type="HOGENOM" id="CLU_004844_1_1_1"/>
    <dbReference type="OMA" id="EGIMIKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="430"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="726"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="941"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118410" checksum="10E00FFB5BC79E9C" modified="2015-03-04" version="1">MAETSSKPDFNNELDNEIQYAVGSCSIDELNAKFPNRPQNRHPTLPFHDLFLTLFNPLNDNRNIRRGPLAKRRLNGPKSLSPHEQRTIIIQRFITRWRAKVGDDFFPALRLILPGRDRDRAMYGIRENAIAKILIKVLRIDRHSEDASNLLNWRLPGLKKANPTSVGDFASRCYEVLSKRSIRSNPGDMRISKVNELLDQLSVLSKETDQAQVFDKFYRNMNAEEMMWLIRIILRDMRIGATEKTILNLWHPDAEALFNVCSSLRRVCWELTDPMIRLENEMTGVTIMEPFKPQLAQFHMHDFQRVIKKLGCNIEDKEFWIEEKLDGERMQLHMVQDQSTPGGFRFFFWSRNGKEYTHLYGNGFEDKNSSLTRFIRAAFGENIKSIILDGEMITWDPKANKIVAFGTLKSAALSEQQDIHDDGLGNRPLFRAFDCLYVNGRNITQYILRERRQVLEKTLKNVYGRIEIHDYLPATTVDQIDEELRKVVADSSEGLVLKNPRSAYRLNSRNNDWVKIKPEYMDGFGESLDCIVIGGYYGRGNRSGVLGSFLCGLRVDKNHIDKGAHPMKCYSFCKVGGGFTASDFARIRKMTEGKWIDWDRKSPPNHLIVLGGEKKKVERPDQWIKPENSVVLELKATSFIVSDLFAVGFTLRFPRFKKLRDDKSWEDALSIYEALELKNRTEKKTKASEFNVDRKKKKAAVQKTKRELVILGNEEKIEKKEAYTGPRTKVFEGLNFCILSEMLNPQKKTKAEIERLVKMNGGNIIQNPVIQENTICIGDKHVVRVASLIKNGEIDIIKPIWIIDALHHLEIDGSSQKQFLPPFEPRHLFHATEKTKKLIKNSVDIFGDSYTRDVSADEIKYIMANMTVSIHSKSTTDLFRLLGLENHERNVIRQAPGWIFLGFRARFVLFPRNDRIDHDHDSNYETGDSDINNLDLHLACSYFRFLGGQIATSDDDQKITHFISVGDSSCNQSSMTSKRQSRKKYISSLQQQRCSTCHVVTLNWLSDCWTQQKLLDEKDYAIDSTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB7</accession>
    <name>A0A0B1PCB7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ntf2 and rrm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000211">
        <property type="protein sequence ID" value="KHJ35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCB7"/>
    <dbReference type="HOGENOM" id="CLU_022209_2_0_1"/>
    <dbReference type="OMA" id="RPRGNAY"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="393"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="55764" checksum="7E6609671A056860" modified="2015-03-04" version="1">MTTNGSYPKQDQSKTESDQFPANSVTESTPGNPPRHNHTKDEVGWCFVEQFYTTLGERPEQLHLFYGKNSQFVYGPEAESSPVSVGRDAIQERFKELNFQEAKVRLSNVDSQASYDSIVVQVIGEISHLSAEPKKFVQSFVLAQQSNGYFVLNDIFRLINDDLEEGNTESNHEENIPASSLEAKPENQKEEAIPMKHSPVPLKTKTIDENVEEPVGIEEPPSQEPKIINGGSFSELSVAVVSEAEVTKPIEEELRPEVIQKTTEEIKEAEKPQESSPTLTAARHQNSGKTQTSTQSTVPPQTLSWANRVAATPVSNPKPAVPAVPSKNSITSKNRTSSSTTKSTQATTTAPKIQPEKEKENAPIGSGWQTAGDNQKKQNRPQSISAPPEKEGTLGYIRNVTEKVDAEELRSVLSTFGNLTYFDVNRFKNCAFVEFASAEGYQAANNASPHLVSGEPIYVEPRRHKAGYGGNGYYGRGGANQRGRSGYSNRSRGSGASPRGRDQSNNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCF8</accession>
    <name>A0A0B1PCF8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000056">
        <property type="protein sequence ID" value="KHJ36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCF8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCF8"/>
    <dbReference type="HOGENOM" id="CLU_077208_0_0_1"/>
    <dbReference type="OMA" id="YTEWADG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="26970" checksum="7F65894B9B6EB677" modified="2015-03-04" version="1">MSFRSVKRAVGAVRPRLAISGRTLPCLTTSLTSHRSSSAISNPDPKKKAQSILDSLPGNSLISKTAILSSTAGVAIYALSNEYYVFNEETVVAFCLLSIWTAVFKYGGPAYKEWADGQVNKIRNVLNAAREGHKEAVEGRIKSVKQLSGVVDITKTLFEISKETAQLEAKAYELEQKTALIAEAKSVLDSWVRYEGQVKIREQKELAETIISKLQKDLENPKVLQQILQQSVSEVERILQSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCK3</accession>
    <name>A0A0B1PCK3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000171">
        <property type="protein sequence ID" value="KHJ35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCK3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCK3"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OMA" id="CDIRGVF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="37117" checksum="C2A2FD48E1C9E305" modified="2015-03-04" version="1">MRGIRLRKLVKGPSELTVTDLPDPKLKDDQYLVEIHATATNYFDLLQISGRYQFQPQLPWIAGYEFAGVVISIPRYIPGGHEAKFKVGDRVFGASQGAYATKINVDEDSLRPIPEGWSFSDAAGLFITAPTSFSALVLRAGIKEGDFVLIHAAAGGVGLAAVQIAKAYGATVIATASTQHKLDIVKSFGADYVINYINPTWPDEVKAVTPGKRGVDIVFDPVGLIEKSTKCTNSNARLLVVGFAAGSIEKLPLNRVLLKNINILGLFWGAYSKNEPKVVELVWNGIFELIKTGQFKSTVFTENELVGLECIQAALKALENRRTWGKVVVKIPQNEDKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCL0</accession>
    <name>A0A0B1PCL0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iron-sulfur cluster assembly 2 like mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000911">
        <property type="protein sequence ID" value="KHJ34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCL0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCL0"/>
    <dbReference type="HOGENOM" id="CLU_069054_1_0_1"/>
    <dbReference type="OMA" id="QFKITDN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="237" mass="26215" checksum="F80C9B7426020FEA" modified="2015-03-04" version="1">MAAQKCCFRLKNIYPLRIFLQTELFRRNGFLTPLNFDFLLSTTSKITHTQYLVARNSNSYRNSLRCYSASSKRPKTTAILNPLKDEDGTDMKIEITPRASNRLKEIMSQDSNPNLALRIKVVNGGCHGFQYLMSLTTLPSDINSTVAQTDDNQYHSVKNLISDDSDNNGQATLCDDDIVFAANDGTGAKVVINASSLEVLKGSKIDYTMELIGSQFKIVDNPLATSSCGCGTSFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCW4</accession>
    <name>A0A0B1PCW4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nadh-ubiquinone oxidoreductase kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCW4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCW4"/>
    <dbReference type="HOGENOM" id="CLU_081626_1_0_1"/>
    <dbReference type="OMA" id="GYPCRTF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="216" mass="23891" checksum="CD447260BDC3500B" modified="2015-03-04" version="1">MLGETFNVIHKLTLHISLFEEIQMSATAATNSVKAVSRVIPVHKKYTVQSYGIWERIRRIFAIAPDRSNGVPLNSQYRNPPPGSNEPFSFIDPVTFPAGDIADNPYWKRDSRRSYPQLSFVTQKDAVGLLKLGSMSSKINLVGEAEARVPAEAEKEGEAGLAAYIRKEGKTDILATFGKDGLPPLPSGAYLKVHAGKYNLAEENSYPESYPCRSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCZ3</accession>
    <name>A0A0B1PCZ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000133">
        <property type="protein sequence ID" value="KHJ36128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCZ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCZ3"/>
    <dbReference type="HOGENOM" id="CLU_017965_0_1_1"/>
    <dbReference type="OMA" id="LEDIWIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="547" mass="61349" checksum="709FF4414DB5DE0E" modified="2015-03-04" version="1">MSPEAISPYSDRPIRPLPKRRLRERLSPDVVELIKYPLAPRAKPPMFYHSYNFRGETGSNGSVEFLNSGERKRSDELEKNYVSRRNDKDLTGEIEEAAYSDWVFSRRSIDLTTASYSFLQKSDTKNYNSQPPGSTASSVDGYDSFENTNNKKKRKIPTPGESNLNGLRISGDVIGSSSPDDIEDLVHQSQSSLQGICGPGRGRYGRNRNGKGPINSFSDISGNWSCVRLSKQRQSQWSSPPESAGIISRSIASANAEINSVTANQLQEDACLQQHASKKSSSASTQFTFSCDTQVPGWPGLNTSLSVQQNPLPTKMSTHATQTSPKITSKRSTVCSKEAFTAQPYTSNGIKQDQDQGMQSKKTRQRPGKDYLSAARQRRHQQGYRNYHSQIESDDVWICEFCEYERIFGTPPEALIRQYEIKDRRARKQEAERRRLLEKAKMKGRKGKKVNKSNTKSNLNHDRQSHIPNKNIHSSTEKGFLQNQASSNHSEEFIKDDFDHTAGFVEDRPSKSHCSQPNLSDIESTSSGLGMCNDSRLDVSNESYVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCZ8</accession>
    <name>A0A0B1PCZ8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000823">
        <property type="protein sequence ID" value="KHJ34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCZ8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCZ8"/>
    <dbReference type="HOGENOM" id="CLU_055871_0_0_1"/>
    <dbReference type="OMA" id="ISSKHTW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="239"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="46750" checksum="B53F762F071F1C1D" modified="2015-03-04" version="1">MTRLENHTFRYAIINDNFTIESQNYNDHYAFLTSGRYNSDRFYEIIIDTGASKHSTAGFQQFQAYQRIKPSLINKTKAGTVTVQFGIGKSTSIGSTLVDTPIGTIEFHILPVDTPFLLSLSDMDKLGIYYDNTKNLLVSPNSKFPVSRRFGHAFLIWGIFLESLISSSFYSNPCFLNETELRRLHRRFGHPSAERLYNLLSKSGHNDVPREYINQINKFCDHCQKHRGPPQRFKFKLQDDSAQFNHSIIVDVMYIDNHPVLHVVDEATNFQAARWLQNISSKHTWDAIRACWIDVYIGPPDYIVTDAGSNFTGKEFHQCATSMAVCVKNIPVEAHWSIGLVERYHALLRRSYEIIYQELKGESLSRDNILQMAVKSINDTAGPNGLIPTLLVFGAFPRMTQLDPPALSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDG4</accession>
    <name>A0A0B1PDG4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative f-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDG4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDG4"/>
    <dbReference type="HOGENOM" id="CLU_025082_0_0_1"/>
    <dbReference type="OMA" id="SRLDRKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="693" mass="77791" checksum="7E180C128DC84B36" modified="2015-03-04" version="1">MPDKATMPDAPQLSRRTKFIHKLRRIYLGRPLSHISPQKRSNKSNFRQSNFSNMTTVSGDASRQHNGQTCSSSSANNCSSKLISPTAIIRKESILLKDGIKICAGNNTIVSDVTQLLTHDSLILKREDSFIQDTIDYLPTETLALEASDQCLITEYMDMVDTKFPNWQTNFDFWAEIPPEIAIGIFMYLTPKELVRVSIVSRRFYNFCYDGQLWTSFDASNFYKDIPAESLAKILVAAGPFVKDLNLRGCIQVEHHQRAEAVVKACNNLVNTTLEGCRNFQRLTLHCLLIGNTKLVNLNLTGLTAVTNGTCKIIAQSCPCLESIDLSGCTRMDARGLRIVVQGCKKLKDIRAREIKGFGCIELAQDIFETNVLERIVFSGCTDFTDHALRTMMHGKDPEIDILTNLPLVPMRKLRYLDISRCYRITNFGIKAMAHLACNLQGLLISGCSRIGNDGLKDVVTSAPQLTLLDLEEVSNLTNDFFKDTLAKASCVLALKHLSISCCDQVDDNGILPIFRACKNLESVELDNTGISDLVLSEAANMLRSRSKVGMAQILSPVIGLRLVVYDCQNVTWAGIREVMSRNSEFHKSTSDEISAQVTELISLKCYYCWQMTVDEHTKRLLRGDIPAAQRLEKLWTDWIIAKEENSTRVSGSRHRRRRRAGEARIIHAIDGRGDRNRSRTRLILNTSSCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ6</accession>
    <name>A0A0B1PDJ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative tgf beta receptor associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000565">
        <property type="protein sequence ID" value="KHJ35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ6"/>
    <dbReference type="HOGENOM" id="CLU_008225_0_0_1"/>
    <dbReference type="OMA" id="DNWKGNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="44"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1187" mass="133652" checksum="4849BDD33C6CBDBC" modified="2015-03-04" version="1">MRSRSTKKSDSIECRHDGETGPYILRTLITGVPLSAEAEAGDKDIHITCVEFLDQNLYIGTSASELLHYVQIPPNPGDQASSPSYILASRILPAFHQSQKTGLPGIQQILLLPNVHKACVLCNWTVTFYSLPELSPVFGNTQVRPCNWIGGIDLNIDPKADVEDNVSPSATILVSLNKKIRLVKINETPRGLRTIDFSGSIISVRRDSYACVADERSYALLDVDRLLKIPLFAISSLNDPLSQSGVPPPNETADTFSSEHTNDTLLIKEETLKGQGSIQGTILNAAKTIRSNINIAQNSNIDGAVEGTQEKISEQDLSAPASNQSFSSLIQIKPSNTASPQHTSSVIDQDNTSLKLTKPSNFLKPHIVSPTPQEFLLVTGIGQNDPGVGMFVNLEGDPTRSTLEFSQYPLDIVVDGRGVGVEPTPSTVNYEEEGYVLASMICNENDFGIEIQRWDLNLGQNDNEKHWLRIPSEFQINNLPASIGLRSVTDVEEIYFSEAVDKLSLKRMRPFQTKFNLDESNSLHPKTFTSTTDESRDQLICEDLSTKQENKRIEEERQFSRRFGRAQSRIVVWSGNCIWWTVRNPMVLRLDACIPNILDKIYQSNKICSSLYQQLLNMIGILLNHEAKTETEYLSLAYLRQRAGLLLFLSSFSKFVCPVSESDYRKIENALLEGGIDPRVILAIIPFLRNEIDEGISGIWIHGGIKDVIDNFIKDPAPESFDLTEKTLVSDQTLHFLKRYLTAWRKKKGFGSIANEYEIFKSVDAGLLVVLLKLDRPVLACSLKTNSVRLELYDLVDNGIDCFERAITLLESEKRLYVLSRLYQSRNMENKVLETWQRILDNDLDIGSEFLEGEKIVLDYLLSIHIIPLIEKFGVWLAARNPKLGVQVFAEECSQVKHEPSRVLDILRSGASAAVKDYLEYLVFQKRHNEYINELIVYYLDIVTEKLEKSQESKLILRQSYESYRALRPPKPTYHQFITENAIQEEWWQSRLRLLHLLGGGQDSISNYDFNAVFKRIEPYGQELVPELIILDGRKANHDKALRLLIHGLGDYDTAINYCLLGGTGIYHPVSGTITRDTVPSWDQQVTLFRVLLSEFLNIEDVNNCVQQTSDLLERFGSWFDIEYVLRVIPDTWSVELISGFLINAIGQIVRERGKILTVKALSGAENIKANLELIGKINAAGFSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDN8</accession>
    <name>A0A0B1PDN8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000062">
        <property type="protein sequence ID" value="KHJ36348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDN8"/>
    <dbReference type="HOGENOM" id="CLU_2387799_0_0_1"/>
    <dbReference type="OMA" id="LEWGERE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10914" checksum="5EAB53079EEAB66E" modified="2015-03-04" version="1">MLYVSPLFKLDGLKNAFGYADDVAILETSNSLEMNSNKIGKVINQALEWGEREGLTFDRGKSELIHFTRRHRHKNYNPAIQTNEFRIEVNQRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDR3</accession>
    <name>A0A0B1PDR3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative yl1 nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000370">
        <property type="protein sequence ID" value="KHJ35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDR3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDR3"/>
    <dbReference type="HOGENOM" id="CLU_008699_2_0_1"/>
    <dbReference type="OMA" id="PVISYWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="584" mass="65162" checksum="52959C7BC385196B" modified="2015-03-04" version="1">MGQSNEESTGITSSTKNNDGEESEKDDNEKNEPVELLVNTRAKRSTAGNLLHTLLQQQEHDDELGLIFAEDEDDSGFLDMEADQSDIPMDSSSDEEDKGSELGNDLEGEKELQKSLKEARMRSKKNGIGKYKIIKKTPFESVSSHSAQQPKKKSERTSWILNSIEAPVRASSRQTTRQSKQQLQVQMMDREIKRLKQLANVEKTAAAKVAKEAPLLTQEDRLREAARVEKANAKSLSRWERAEREREEEQRLRLNNLHNRHLEGPVITIWSGMATYVGGKLQKIGKLEIISEKPLLKKRKVAGNEEDNDKEDQEEGEKSPESIPNSIKIRNETSTSFAKPSDENPEASASDPIMPSIKSQALGQAPNQSSEKLIPHYSSSCLAPPAGLPLTTSSHPLFIPPSLAGSPKGLVYCSTPKNNMQFLPINHQSHLSPPNQISPAPLVPTLPLSPIITEHCVRSSLIFSNFSDTAIKSRETQLRILFPHFHHFNTTNPRTTISRTPAKGSRNSRAYYKSFPCAITNYPAKYKDPKTGLYYSNLYAYKQLQKLQKGEIWWSDLVGSFVGSGSLNPAKGVPDNFHTGIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE26</accession>
    <name>A0A0B1PE26_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000492">
        <property type="protein sequence ID" value="KHJ35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE26"/>
    <dbReference type="STRING" id="52586.A0A0B1PE26"/>
    <dbReference type="HOGENOM" id="CLU_1751058_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="149" mass="17174" checksum="665F6A4EA01ABE11" modified="2015-03-04" version="1">MRIQKAVWLKKKLDLNKTAGSLILWLEQAESADKAITKGIMWKCDIKATEIFRSGFRAMQCFNFQRYGHIARVCTMEAKCDQCADNHNTRECPGKKQPRCANCGRKHISWHSSCPARIAAKAKAIQNRTQDPGTYTTQKNRNDRQKNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE53</accession>
    <name>A0A0B1PE53_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glucose repressible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000487">
        <property type="protein sequence ID" value="KHJ35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE53"/>
    <dbReference type="HOGENOM" id="CLU_179513_0_0_1"/>
    <dbReference type="OMA" id="GHNAKAD"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="71" mass="7428" checksum="C1961A00E50CC9D6" modified="2015-03-04" version="1">MDTIKNAANYVSESVQGAGSEASKDTNKKVAKDGDASLGSRATALKDAAVDKKDELSHNAKADVHKESSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE71</accession>
    <name>A0A0B1PE71_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000315">
        <property type="protein sequence ID" value="KHJ35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE71"/>
    <dbReference type="STRING" id="52586.A0A0B1PE71"/>
    <dbReference type="HOGENOM" id="CLU_047729_3_2_1"/>
    <dbReference type="OMA" id="GAKTDFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059089" evidence="2">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="23334" checksum="70FC82A14FED967E" modified="2015-03-04" version="1">MFLKSLFVAIAAAQLIASHGVIIKAVGNLGGNGTALGVDGSTPRDGTKQNPFQVDSTRFKNNNADACGETLKGGPNEPAKQMAKVVSESSGMPMISAGGMVMMTLHQVNGDGAGPYECMIDSTGTGTGGWTKMEVVTNVPGKNSRSKAKATEFPLTAKVAADQKCTGSMAGMSNICMVRCNNAANAGPFGGCVPVTMPNGGANSTTASSTASGKAPKSTGGAVKVARSINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE95</accession>
    <name>A0A0B1PE95_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1679</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000312">
        <property type="protein sequence ID" value="KHJ35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE95"/>
    <dbReference type="STRING" id="52586.A0A0B1PE95"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="72"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="412" mass="45335" checksum="71D366CA99CFBE86" modified="2015-03-04" version="1">MAERKSAFNLQTCARPNILSLKPYRCARDDYKDDGTNILLDANENAYGPSILCQELLGPLESLLSSPINLAGLHRYPDPHQIEVKQQFCNLRNTHLHTCKDIGPENLFLGVGSDEAIDALIRCFCVPGVDKILICPPTYGMYAVSAQVNDVGLVKVPLLPAPEFDIDLNSVLSSLSSPSSIHLKIIFICSPGNPTGSLIKKSDIQRILEHPTWNGIVVIDEAYIDFAPENSSLAEWVAEWPNLVVMQTLSKAFGLAGIRLGVAFTSPSIAALLNSLKAPYNINSHTSAIALKTLQPAGINLMKSNREKVFKQRERMLEELPKIQGIGRLRGGTESNFLLLEILDSKNEVSNVTAMQLYQCLAEENGVVVRYRGMEHGCLGCLRITVGTEEEVTIVLSKLKEVLSRIRTLQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PED9</accession>
    <name>A0A0B1PED9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000450">
        <property type="protein sequence ID" value="KHJ35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PED9"/>
    <dbReference type="HOGENOM" id="CLU_2348244_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="10866" checksum="99748580D20D2088" modified="2015-03-04" version="1">MLTDEIERVSSKGLDFVKIYATSKLEALHRTWIAFFSNIHRGGSRVFDESGVAKIFKKKHLIGFRKRSNGHHNIKTCSRAPSCGNCGSTMHAQEACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEN4</accession>
    <name>A0A0B1PEN4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative vesicle membrane receptor protein (V-snare)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000528">
        <property type="protein sequence ID" value="KHJ35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEN4"/>
    <dbReference type="STRING" id="52586.A0A0B1PEN4"/>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="120" mass="13146" checksum="17EFDF80D06885CF" modified="2015-03-04" version="1">MASTGDRPYDPYIPNESATGGGGNAAPGNQRTAALQAQIDDTVGVMRENINKVSQRGERLDALQDKTDNLAVSAQGFRRGANRVRKQMWWKDMKMRMCLFGGIVILLIIIIVPTVVATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEY5</accession>
    <name>A0A0B1PEY5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphopantothenoylcysteine decarboxylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000219">
        <property type="protein sequence ID" value="KHJ35880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEY5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEY5"/>
    <dbReference type="HOGENOM" id="CLU_019412_0_0_1"/>
    <dbReference type="OMA" id="HVHVLDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="593" mass="67673" checksum="DDF31EF8EFF30C82" modified="2015-03-04" version="1">MPVNELTKKHVLIGCNGPTELAESLIGNFKTLNNFAIEIKAILNHQLLPACTLSRKTPPLEDKYLEEKGLKVNPGNSIGTLNKSSHRQAYELCQWTDLLVLAPIDADTLAKMLQGICDNLLLSVLRGWDISKKIILVPAMTVIMWENPMTKIQINHLQKSWPCVQLMPPILWSYKLKRNYLSYVDLDGLVNVIKYWTGLVNSSHSVDMNDYGSLSIARSDVTSKTALPAEIWTLIFEFVGDWEISRALKVYTNISIPTEWQQNLKKVEDKLETYNRSLELIILSASTKKIIDKLNEAPDKIALSALCVKLVIKFSLVDVLTFLATSRKDILWTSFGRKLIPTMASAVFGKIKILDWWLNSASFPSKDYSCEAMDGASKMGFIHVLEWWRRSNLPLKYTEVALEQASAKGYISVLDWWSQVSNERVYFPFEPQNFHYNHTNYQEFQPSIPLLPGKSLITAAQNNQAQVLRWWDKAPIPIGHSESVARVASQYGNVEVLDAWLDLKGEKMSFDSKILIEPTKNGHINVLQWWKDLSRGSCGKPGRTIQYKTFDIEEALEDSTQNEKTVLEVKKWWAQNELNLGLRVQEWTRLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFA4</accession>
    <name>A0A0B1PFA4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative vacuolar atp synthase subunit d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000346">
        <property type="protein sequence ID" value="KHJ35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFA4"/>
    <dbReference type="STRING" id="52586.A0A0B1PFA4"/>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OMA" id="QFTRIKK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19042" checksum="1240966ADCC8768D" modified="2015-03-04" version="1">MSGVQGREAVFATRQSLGLMKSKLKGAQIGHDLLKRKKITRRIDEAKRKMGKVMQIAAFSLAEVTYAVGGTIGYQVQESAKSARFRLRTKQENVSGVFLPVFESYCADGSDDFGLTGLGKGGQQIQKCRDTYARAVETLVELASLQTAFVILDEVIKVVNRRVNAMLVFSFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFJ1</accession>
    <name>A0A0B1PFJ1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000312">
        <property type="protein sequence ID" value="KHJ35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFJ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFJ1"/>
    <dbReference type="HOGENOM" id="CLU_005049_5_0_1"/>
    <dbReference type="OMA" id="GWWVLEF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="63"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="575" mass="64956" checksum="400516742CCD922F" modified="2015-03-04" version="1">MGINTDSWIESMYPTQSFSSATSARTSTFLKSGIMARSSEKHAKPFPSAIHAVKDSENLHESRTLIICLDGTGDQFDNDNSNVVNFVACLKKDHPRQITYYQSGIGTYNEKGLSNGVAAAIDMSFGSGLGVHIKDAYRFLMQNYKEGDKICLFGFSRGAYTVRCLAGMLHKVGLLPAHNRAQINFAYNFYKNDTEEGWRMSADFKKTFCADVTVYFVGVWDCVASVGFFPRKLPFSKSPTNNVGHFRQAMALDEHRAKFKICQYAHEDPTIITRHKKTTEINTSKNRKGIFGLFSKNDTVAEDLTANLGKFSFLKRAKTMSESVNPNSDDKTVESSTNRLPKKAESIPTDALEVWFCGGHADVGGGAVHNLERHVLARIPLRWMIRQCFECNTGIIFKTAALAETGIDVDSVWPVYKIPKRPVVGPSPTHLNKYAAGQIAPIQRRSTALGLESSNHVSPLEKPSRHEILENDKTIEEDEMLPEQAEDYFDAMAPINDQLKLAKGWWVLEFWPVKIRRQKLESDEWEKVVRPNLGTYRAVRELEPNMHWTVEQRMLDKGYKIQARVNRRAHWNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFR9</accession>
    <name>A0A0B1PFR9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000127">
        <property type="protein sequence ID" value="KHJ36145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFR9"/>
    <dbReference type="STRING" id="52586.A0A0B1PFR9"/>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="OMA" id="NCEKGVG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="779"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1126" mass="128095" checksum="114BA2228C283AEE" modified="2015-03-04" version="1">MPISEDLIDFQIIEDQKENIQSLPGGRSARALACVFSPSSTSKAPTPSDSKNLNDIARQEYESELACMSESDDPLDIYDRYIRWTLDAYPSSQATASSKLLPLLERATKAFINSAQYKNDQRYLKIWILYIKSVSDAPREVFAFLARHGIGEYLALYYEEFAAWLECAGRWKQAEEIYRLGVDKEARPTARLLRKFDEFNARYSKRPIDTNQPSSPALPSIRPALMAKLDPFAPAASRNNQSPTPNTGFKPSARNGKQKLQIFSDKDNNEPSSLSHSDPAGWQSIGSLAERKKENTLEAKPWAGETLKAGGQGKSSIKIQVYKDMSLSKSQFKYPQITEPAQHQITLNQKGKRETIFVHLEELYPTPEIFGSELSIEELRAKHRGWLLKTWKPEKCSTKESCRERRARKMKVREINETQIIKAKLSSPIGPKIMKRKSKEQTMTIHTKAATDDIYDLFNQPLLAVEKMGGNDEDSSDNEDEDDMTDGDYTSGCESPGTGRPLTMSEDEDLEETSDLKSASEWTELSFKKNSPDCQNEIKNIRDQKRSMIPDLPPKTPISLESLTKIDPISLQKFSSEHELIAQVNRDFTYISQNRLPFMTPIAEQTESSVSVATILPEENNRFIAKTPTKDSSNKLRKFIEDSRTYDLEIRTDNKKVEDLIQPSPCSSPYGSKVSLINLKLSDDETNFASKITIKREIIKDKQCNPTCHILHNTILSLVQPPIHTYNGFFDHSNEAGAKTSEIRKYIKSLSKSHRKGSDKVLNSQAPPVLRFPGTLREYVIQRELGAGTYGPVYLVESKLAEEQDMIEQERFGKSVSDRSLSSKRCVLEALKMEHEPSAWEFYVLSQARYRLANTRAAQSVIKVHEMHLYNNESFLIEDFREQGTLLDIINIYKEDKSSSGALDETLAMFFSIEIFRTIEELHSNGILHGDLKADNCLVRFDPIHQSENWGSCYRRDGSEGWHRKGISLIDFGCGIDMYVFNPQVQFISDGEISPDDCAEIREMRPWTYQIDYHGIASIIHSMLFGKYLDTVADNCNDVGPGAKKIWRLRENLKRYWQKEIWAEAFDLLLNASSRIKDNAENSMPLTHSLSDCREKMELWLEAKSERGIGLQASIQKLESTLAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH74</accession>
    <name>A0A0B1PH74_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf1690 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000223">
        <property type="protein sequence ID" value="KHJ35864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH74"/>
    <dbReference type="HOGENOM" id="CLU_093897_0_0_1"/>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20669" checksum="105815D703C8D0CA" modified="2015-03-04" version="1">MGSQLSKPDTSNNNSQVNTGNAVQFSQPFVDYLQNSSETDSIRAKALELEIQSRVNAELQRLKSVTAKEYAELQAKISDNEETGQRHSNDSHGNDEASLSVKAGDRLRQLGREAVQGDILELKTKIEKSKHVRELDESVVKAKSEVISCLKENDRRPLDCWAQIEKFKNEVARLEDGWIQKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHF6</accession>
    <name>A0A0B1PHF6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative beige beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000176">
        <property type="protein sequence ID" value="KHJ35979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PHF6"/>
    <dbReference type="HOGENOM" id="CLU_000175_2_0_1"/>
    <dbReference type="OMA" id="EMSNFHY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1818"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1994"/>
            <end position="2289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2422"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1257"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1725"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1742"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1761"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1786"/>
            <end position="1806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2629" mass="300033" checksum="86418303D6DB7B8F" modified="2015-03-04" version="1">MRGRKMSSPDRRPISPDSFCSPSDDADPLVDLRLLLANFAAVLQPQNQGSYPNIKTLIEISKSIQHYISASSCIVRVNDNFRHLQGFQILLDTLRSFVGYYHPIIRNVEENNLMFELLEAIFEILALNFRDNVRNQRFFRRRIEYGGWSTLRQNIADIGICGGEQDSWGELKLIGVMISFALGDKRLIALCQEVFELHQSMTSEVSLVSERLDEIKGPKISHNYSLTEYIDKRLSEIIQDGTLLHFPDIIPILIDFWKLISRNNENPNPAALIAIKTLTRISLLSSHNLWALQSTGILSSLLPLVFSSDSLLGPHERQSVEILCESLISLGVNNLSDTEYLIRSKLPGATDFLLRALKSSCVPPCVHFDLSLYGYASIELPSLGRQFPPINMPGYTFTAWINVDQFDHKVHTTLFGAFDSTQNCFVLLYLERDTHNFILQTSVNSSKPSVRFKSTVFTEKRWYHIAVVHKKPRAISSSKALLYVDGEFVEQVKCQYPASLPLSNTSTESFTSFTSSSYKNNSIQVFLGTPKDLSSFVGSNLIFTRWSLSSAHLIEDILSSDLIAVYYRLGPLYNGNFQDSLGSFQTYEASAALGMRNETLYPGRDDRSDILSAIRGKAGNLLPEIRILFSIIPTAIYGDDRRSIYESQLPRTLDKNLSHHLTQLTFNKCSLVAINAAFPRIKNALTCTYGTATLNGGPFVIVPRLLDDTLWQLGGFTPIALKLVENSVTSSEIIKAVEILFWGIKGNWRNSEAMERENGYAILAALIRGKIGAGTVISSKCSAENLNVKKEERNELSFRLLNLILMFVGYNSKNPEESYIVNPLAYRIFLVDFDMWRKTPLITQMLYYKQFIMFGVKSKFYEFNLRRLFRMRVVKRFLDALKAEAFYEDIFPSFLEAFTSLVKCNLCVEVFRSLALFITYSLYKPQASNPRNAKNALNIPSTPQTSSKRPRIVTISSCESRKNYVTKRQCGIKVLEIYSNILCERGNTSNIRKFSKTVTNKWLLHLLADDEAQVILHGTKILVRLIVVQGSSYMTKFANKTGGFVIMRHKLKRWWNLPALWRLCFCVLFNKDVAEIDLERSFELFSLLEIFSDCRITNPQVLPVITSMLQHGVKEILRNQEDPDSPMTTYEKEKYHDTPFLEIPKYAPTTRRRSISLTNDIEFQQLNKPRKEYLSGQAAILQTVVRFFADLHGKAFEFRDFALSSDYVKLLLAVLFPAIVSTDIVSAETELNSRDSALTFEGNDVIIRPITRVMRPPTPKIKTPVETQSTTSNTASRTKAHRHGFSFVLLTSRPSEFSPSSAKLTLVTSPGKKSITQQVSNALIEDLLELIICVFIDRVMFRKEFPGFGLFSKTPPGFKEHQVYFTTYILRNTISHLSNTIQLDQKSLWEPKVIQNMARFVAHICEAVFEGWFLSGAEPLIDFAGTLLEYLQRPEISKIKNVRLCHQAVVIIKGVFFRVVLLRLSELDSRHVSEHEAVVFMDKLFYWQAVLLSSDTSQDDFLKLVCYQIYLKLVDPRERVQFAAANLWRIMLVQKPAETLSLFENITSPEHRKLINGFRKLVELDNEVFIRWVDERRTELDLLFSGAMSKTWEKFVSSENEKTEETNKARVSRRKEKLKLWHSEELNEEEIIRSYNIAAASWMKNIYMSEHLKYQRGQQDQQDNFIFLASIFSNMDYELHRPCAIFHQESHIRWKLDRTEGRNRMRIRMLPDRTSLAYNYLPKRRTTESSINSSNSDIRSRAQTSNMPPSSTLSLGEYDLGSNNESAENNTGERSENSAQEIENIIPEDDFEIVDDPNDPGEDDNYEDKNRKVMRSLQRGDQVQYVFNVSRIIGLEACEGLCIIGKDCLYLIDNMFQRSDGEIVDVMQAPKEERDPYLQMISGKRDLRHSSDDKSLHVRADQLARSWKWNDLISISKRRFLFRNVALEVFFTDGRSYLLTAISPSSRDDLHSKIIIKAPHTNGNTCLPNPEDGWRLETLKVSEEPPTSLSHKFGNIFNSSPWNPATKKWIKGEISNYHYLMLVNTMAGRTFNDLTQYPVFPWVLSDYTSSELDLNNPASFRDLSKPMGAQHNSRASEFIERYKQFADMGDQNTPAFHYGTHYSSAMIVTSYLIRLQPFVKSYLLLQGGNFDHPDRLFYSIKEAWLSASRDNMTDVRELIPEFFYLPEFLTNSNSFNFGVRQGKGGAIDTVELPPWARGDPKIFIAKHREALESPYVSRNLHQWIDLIFGCKQRGDAAVDSVNVFHYLSYHGAKDLESISDPMQKLATIGIIHNFGQTPHQIFTKPHQSQEDIRSKPKRLDTSIHSLKRLPFPLFEFYNRISSIDYLPKTDRLLCSTACRLNLPPYYDKYLEFGFADGSIRFFYTDSNKPAGLFENLHQGQITTAIFASSTLLVTAGEESVVSIHNIITSQGKTVDLQPRTSLFGHRAPVTTLAVSKSFSTLLTASVNGVVILWDLNTFRFVRKLSSENESISCASINDVNGNIMICRGQKVTLYTLNGEIFLEQVICDDHDDKIASCAWYEGIANEWIENELCFTGQRGGVVNCWKKTVSEGTSNWNLELVKKLQHYSAKTDQVCESSVIGSLVIPRIGRSRSNISISDSEGSITCIKPMAQSIYTGDEDGRVYEWSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHS5</accession>
    <name>A0A0B1PHS5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="JNVN01000065">
        <property type="protein sequence ID" value="KHJ36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHS5"/>
    <dbReference type="STRING" id="52586.A0A0B1PHS5"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OMA" id="INVSYNC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="115"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="562"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="686" mass="76081" checksum="C868918C9D8687D0" modified="2015-03-04" version="1">MADLKFGSKSCHAGEFEEKSQESVPTISDEAHAVFDPPKMMFEKHPTRPHLKNLDEYHKLYQESITNPIKFWGKLARELLVWQRDFQTVQSGSLENGDVAWFLEGKLNASYNCIDRHAFQTPQKPAIIYEADDPQDSRTLNYGELLRKVCKAAYVLKQFGVKKGDTVAIYLPMVPEALIVILACTRIGAIHSVVFAGFSSNSLKDRLIDANSKVLITSDEGKRGGKTISIKNIVDDALKQCPQVTHCLVCKRTGANIPWTLGRDFWLHEEVEKWPSYIAPESMNSEDPLFILYTSGSTGTPKGVLHSTAGYLLGAAATGKYVFDIHNSDRFFCAGDVGWITGHTYVVYAPLMLGAATVVFEGTPTYPSYSRYWEIIEKHEVTQFYVAPTALRLLKRAGDQHVKKKFKRLRVLGSVGEPIAAEVWRWYYDVVGNREAQIVDTYWQTETGSHVIAPLAGITPTKPGSATLPFFGIEPGIMDGASGKEILDSDVEGNLVFKKPWPSMARSVWGAHNRYMNTYLRIYKGYYFTGDAASRDSDGYYWIRGRVDDVINVSGHRLSTAEIEAALIAHPSVSEAAVVGINDDLTGQAICAFVALKSNSQSLDLSRDLITQVRKIIGPFASPKVIHTVPDLPKTRSGKIMRRILRKIVARDGSDLGDISTLSNPSAIDSICKLVDHASNGTNCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIE6</accession>
    <name>A0A0B1PIE6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative pre-mrna branch site protein p14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000094">
        <property type="protein sequence ID" value="KHJ36244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIE6"/>
    <dbReference type="STRING" id="52586.A0A0B1PIE6"/>
    <dbReference type="HOGENOM" id="CLU_012062_25_2_1"/>
    <dbReference type="OMA" id="HQPDKMV"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="13279" checksum="E55740F70DF297DF" modified="2015-03-04" version="1">MNRGGKLAPEVNRALFVKNLSYNVTPEELFDLFGKFGPIRQIRQGIASNTKGTAFVVYEDVMDSKMACDKLNGFNFQNRYLVVLYHQPEKVVRSKEDLETRKENLEQLKKQHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV12</accession>
    <name>A0A0B1NV12_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004817">
        <property type="protein sequence ID" value="KHJ30197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV12"/>
    <dbReference type="STRING" id="52586.A0A0B1NV12"/>
    <dbReference type="HOGENOM" id="CLU_000288_44_0_1"/>
    <dbReference type="OMA" id="VDTRDKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="774" mass="87176" checksum="F6BFB3C9DA24EF37" modified="2015-03-04" version="1">MSGTNRLSLSHNYQANESSQISYDETGWHKTSEKHYPDRVNYMASRTQAQDSNSSVSMAQLDSQSLNNLIPQSPNSGVIEHDFQRDKVMQPQRSLATESRHQEYLYHNNQSPSTQNTHFTSNIYAKPTAISHYAAGLGNSSSPYGVPPHYGLEGNNISNVEDWKDKGAAVGVREDYDANGKLVLRQVKKGVRDFEFGRILGEGSYSQVVLGKDKQTLKEYAIKILDKKHIIREKKVKYVNIEKDTLNRLTQHPGIVRLYYTFQDSTSLYYVLDLASGGELLGVLKRNGMFDEVCTRFYGAQILDAIEHMHNRGVIHRDLKPENLLVDDQMHIKITDFGTAKLLPDPRNPQGSLSKFDASPDSEDSLRAKSFVGTAEYVSPELLTEKSACKASDLWAFGCIIYQLLAGRPPFKAGNDYQTFQKIVSLEYEFPPDFPGLARDLVERLLVLEPQKRLTIEHIKSHSFFEGIQWGRGLWKQKAPRIKPYVPKSQEQNILKLSNNRSNLCQISHTHSQLTPSQNAHTRPQPRVITQLPPPTQLDIEWSPVLTRNNERILKLGNLIVISSPLPISPNSRNGDPNDGGHEKRRLSRFFGVTTTKRKQRLVIVTSSGRIILAAAGGEEKKLKTEISLLNSDCSWRINTDSKGQETWCVYSYGTYYTFEDTKNSMAIGEPFRTPAQDWIDAVERAKEMAVSQCALGSYSSDVRFEAVSAVSSPNDTLIASSTYSAESISFHDRSNRSHLTKNQASHGLDESENIVRKSRFSKRHSKNGLSVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVH4</accession>
    <name>A0A0B1NVH4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004481">
        <property type="protein sequence ID" value="KHJ30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVH4"/>
    <dbReference type="STRING" id="52586.A0A0B1NVH4"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OMA" id="IWKEEGD"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ30322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="299" mass="33255" checksum="DCA271409BA06BC3" modified="2015-03-04" version="1">MAQVITNSGHDDMIHDAVLDYYGRRLATCSSDKTIKIFEVDGDSHRLTETLRGHEGAVWCVSWAHPKYGNILASAGYDGKVLIWREQGASWTRIFDFALHTASVNIISWSPHESGCLLACASSDGNVSVLEFKDNAMDHKIFHAHGIGVNSVSWAPSSSPGSLISSSGGQGSIKRFVTGGSDNMLRLWNYDVASQSYKQEREPLQGHTDWVRDVAWSPTILQKSYIASASQDKTVRIWTNDPSQPGVWNSKVIQFDVVLWRVSWSLSGNVLAISANDNKISLWKENLRGEWECVKKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVL8</accession>
    <name>A0A0B1NVL8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative of heme oxygenase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004353">
        <property type="protein sequence ID" value="KHJ30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVL8"/>
    <dbReference type="STRING" id="52586.A0A0B1NVL8"/>
    <dbReference type="HOGENOM" id="CLU_038284_0_0_1"/>
    <dbReference type="OMA" id="MYMALFA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="54075" checksum="081ECD91C1A215C3" modified="2015-03-04" version="1">MPRPRTHSHSLSLSERINSATRAAHSHLNNLILERLPLALPPHANDTFIYASGLIHIASIYFTFEDLWQRSLQPPYNADWKIGFDSLALNNLDLNSELRNSPAACDVKSTSHLQNPGVSPRIDSVLRLLRLPDLTRSESLRADIANLMSIEKDDVTEKIQLALKNSSASKFLHHIRNNVTQNPHVLMAYAWVLYMALFSGGRYIFASLKKAAGRGIEFWEQDPCVILQHYQDKKGSKPEEQLSVPLPSSKKHIPAYSTSSTTIGSKTIPGLQFFCFTGDENGEDIKTEFKKRFKTAENLLTNNEKIEIILEAQYIFKYMIEIVLNLDMLLGTDNEDKDTSSIILESNSFMKIRDSVCVTKERLLQKTSTQRIKETWESIFLDYTAKNRMKRVVGFKKPFTFFKGRRHRLKKCLQSDCSANFSLTPGLTDINTLCKKFGFSISLLLRLVILFLMAMALKLLVLWVYKCEYVGVNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVP3</accession>
    <name>A0A0B1NVP3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004279">
        <property type="protein sequence ID" value="KHJ30422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1866629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080353" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14935" checksum="D59220F723025C4E" modified="2015-03-04" version="1">MRNASLAAAAAAAAAATAATTAACATPPSPPTPLASAKSKIFTFTRCRCKRPDMLYKSGIAKKIRTINPTPSGSPVHHRGSQSSSFLHHFPLSTFFFFXFFFFTVDSLGEPFFIFSKIKNRSNKDQFVIPSNWRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY78</accession>
    <name>A0A0B1NY78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005868">
        <property type="protein sequence ID" value="KHJ29995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY78"/>
    <dbReference type="HOGENOM" id="CLU_128909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ29995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="132" mass="14626" checksum="96B9AB242BB75887" modified="2015-03-04" version="1">MNWLDRHGLILISEIGVPAHNLVSVIDLCFASEELVSKCITSSIQKDLDVTTDHLPNFISFSITIHHIPPIPKSRFSTLDAETFRSLIEMQILDVGALTEKSASFIDNRAEVLVKILLCAFEGSAKKSLPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZJ8</accession>
    <name>A0A0B1NZJ8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative rab gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004192">
        <property type="protein sequence ID" value="KHJ30465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZJ8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZJ8"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="ENIRTWF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="205" mass="22879" checksum="0406E4EFC2D655D1" modified="2015-03-04" version="1">MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFSNVEQHATEGVSKILIGNKCDWEERRVISTERGQQLADELGIQFLEVSAKSNINIEKAFLSLAADIKKRIIDSSKSELSGSQGLDVRAQNGSGGMTGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZS2</accession>
    <name>A0A0B1NZS2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nicotianamine synthase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002537">
        <property type="protein sequence ID" value="KHJ31852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZS2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZS2"/>
    <dbReference type="HOGENOM" id="CLU_031919_1_0_1"/>
    <dbReference type="OMA" id="NIDMSPT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="323" mass="36061" checksum="24743D2045339A8E" modified="2015-03-04" version="1">MFEILLHYWHRIVDLWCGSEEACDENIEVNILIKKILFIHGQMVSLRESESFNEIADLFSEIRLICTRPISDRASDLILKNPRIIEITSDLRSFCSAIETNLEKKWSLKAAGDVGSTQEEVCARIRAYPYFNTYVNLIEAELSAMRSIEQKPIKKIAFIGSGAMPMTSLCLIGRLTDTPTNISVLNIDRDAEALELSKVVCERLGSQAEGMEFCHAEAGTSLDLNDCDAVYLAALVGHTQEQKEALLGQVTSKMRPGALLVTRGGRKLRSLIYTVFDPTTERVSNLLDVALVINPNKHNIVNSIFVGRVKQSLTSPDPEETKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZZ5</accession>
    <name>A0A0B1NZZ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004978">
        <property type="protein sequence ID" value="KHJ30149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZZ5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZZ5"/>
    <dbReference type="HOGENOM" id="CLU_432234_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="633" mass="71921" checksum="A25D3B2AD24526FE" modified="2015-03-04" version="1">MSNIQSTVAELVTKLHSNIDQINQTIQSLSDESYNQKLEQLTIQRESAIHSLREKRVDALKEILAQRAREKEDSNRKREWERQLIEEQRVKEWAEILARRKIEDEKWLQAIKAEDDEIEKSRNAEDEKREREREEEERALFEKSEKEIEMLENEMEKSLEEGRITLKKLDEDRKIINAQIEAALSAPAVIPNISFKSRRQKSKDLSRCNQVENPENDFDYGISDPIFASGTSKSSEHEDSNINIEFEKSIPNRKSSARSSTSSSTEPKELRLVSLVQKEMSEEAIRKRDGIFPHKVVSSQINAGSNDLGKRLHPWRRASDVTTKDLELSETVPTPGALPSEDFSGNLLPLFPVKYVNSKTNLTLSRHISIDDKISSSAQKSERNKINSEPVTSSAQKLHANDDDQISPANNEGESSQAKENMIESLDSSSKILQITESSAICQSSLTMNSKDLSSSINQVEMLNLGVKSEEYHEFKGADKTKDNLKMEQVRETSVATKIMGTYKVKEIDENNRDDEENEIKKIQGAKEIEETNGVKDTRGAKENEEADQATEIDEADDVKKIEEANQATEIDEADQAKKIEEADPDQAKKIEEADHVKKIEEADHVKEIEEADQVTEIDEADQAKKIEEADQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P067</accession>
    <name>A0A0B1P067_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003761">
        <property type="protein sequence ID" value="KHJ30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P067"/>
    <dbReference type="STRING" id="52586.A0A0B1P067"/>
    <dbReference type="HOGENOM" id="CLU_021051_0_0_1"/>
    <dbReference type="OMA" id="WHQTFRF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="48712" checksum="5850E6FE10658C4B" modified="2015-03-04" version="1">MRPQWEAKRVQRIRVQVNGTQLAALKNSDVPEIQKDGLNLRQRKKVNRSVQAHDEVAMKTNSSQFIYKYFWQSYPDTPIERLSWATDLVFNYRGPGWNWAISPLPSLPPEIIMQLGEPVPVEMYLNISSVGLRRFNTRRELCRSRLPRLIFGYFLLDFLKVIMMSDPYYKFGPTTYALPVHLKVLSPFMIHMYRQSLSSGTIIAGLAVANYIPPLIISVICGPKVFGLRAEAWYYPSMWGPFSNLCYKGLGGLWGNYWHQIFRQGFTAPTNYLIQKGYMKARSPTAMLVGLGFAFGISGFVHWAGSVTLYAKTYPSHLILFFALQGVGILIQSTFCTILKPSLKTFPKYIRYTGNLLYSLFWLYSTGWILADDFARGGLWLWEPVPFSPLRGLGFGEPDAGWWCWEHSGVGWYSGKHWWESGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0G6</accession>
    <name>A0A0B1P0G6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g4608</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01002622">
        <property type="protein sequence ID" value="KHJ31738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0G6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0G6"/>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OMA" id="NFIKHCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="326"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ31738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="571" mass="64351" checksum="4531C10355C67FB4" modified="2015-03-04" version="1">MGKGTDKLYITHSEWSSTDAYSASTGSNVTQKSSSNTGFKRLPFKFCAASLQPFKNPVCTLEGTIFDVEAISKWLEKNCTNPVTGKPLKQKELISLKFAHNSDADSHSTSPYNADKKGEMVDPVTYKVLTDNTHIVAIRHGNEANVFAWETIEKLNIKPKMWRDLVNDLEFGRSDIITLQDPQNLESRDLSRFKFLKDGDSVLTKEQEETRKSGNVNIPALGRIGDKILKAKDILDKTRKDREAKSIKNRVNNIVRSSTNSTFRPSQIQEKKILPTAAQYTTGKAAASFTSTSLTPETSGERALLSEEEYMLRPKRVKNKGYARIETNLGSFNVELNTDTAPRAVWNFVQLSKKGYYNGVIFHRNIANFMIQGGDPTGTGKGGSSIWGQNFRDEFDGPLTHNSRGIMSMANKGKNTNSSQFFITYKPARHLDRKHTIFGRIVDGLAVLDKFEKVPGDNENRPLNDILMENVVIFVDPFEEFQKQTRDKEDERIQQEEIKSRGGTEDDKKTWTGKNIHRDGFEVTSDQSGKVGKYLKNITHEIKRSSDNDISEVEPVKKKINYAGFGNFDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0I0</accession>
    <name>A0A0B1P0I0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ph domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002610">
        <property type="protein sequence ID" value="KHJ31753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0I0"/>
    <dbReference type="HOGENOM" id="CLU_009306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF42">
        <property type="entry name" value="CONNECTOR ENHANCER OF KSR PROTEIN CNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="143"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="535"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="686" mass="78313" checksum="6FE70C425CCFE631" modified="2015-03-04" version="1">MEPIDTEFEDDSEVEDLSPSLSLGSTTRRSDTTISSLHELRTPNFDSNGFCKLNFDVTKPKPVEGPWGMHLFRGSVDSSSVATEPDAIENYYLKISPATPTTIDFQKFHRSKIETLNRPLSHPFFDLSIDPVDSMILSDIACWTPRHVSRWMHHVGFDILIAEKFEKNDISGAILLTLKFEDLNELDISSFRLRKKIWNEVENLRYSSYKSFEKSSSLDRSVKSIDEELLTLSEENKSHQLEASYTNLINVSKCGINQVDVILPSCIKSGSLSKLDSEIENTIVMEDRNTKVDDISKREGQELLIENFYGQSNPKNSSEPFGKNHTVKEFLSSPDIHKSSFSANEPSSIYDNQVQEKNSKNTLSQLEEANLRLINLRDPQENVKQFIESQSLSMKTDENYLKQKTNQELQSQAPKNENFNNFLAKPQVLDYVRSSATFSPYQMERVAAISPELQNVVQPQLASSRFGVYIPNTDISLSIRHAQLGAVARNVCHSILKNFMKSSFHISRIRYSPSKVAPEFSEDKVDVLENVTADHVTQAGWMRKRKTKILRFDWQNYYFSLKGTQLAMHKNEHECLFDAIEYIDIDDYAIVCSSFATSSKFHAAFRAMSISRKEEQQKNTAPFAFQLVPASVKKGGRLNTCRKIKAHYFAVQSQNERSDWMREIMLAKAMHKKKQGYKVNVNGNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V8</accession>
    <name>A0A0B1P0V8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">EV44_g6244</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01003461">
        <property type="protein sequence ID" value="KHJ30920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P0V8"/>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="OMA" id="WRNKTLG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9 24" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="23">
        <location>
            <begin position="254"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="506"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KHJ30920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1386" mass="156609" checksum="38BCF8ECF54C91D6" modified="2015-03-04" version="1">MAVEGVEGLTMSKNYENKKFRIPEKASIPERFQDEDDVEEDCTAPSGTNTYMSQSVFGMLATVGPQIDYTARFHIQSSDDEESEASPQNAEARETRIPDGSHFNKPVKLRKKFSRHKLLCSVSELGSKSTSTPSSSDLNKRSSVRPKKIAPSSSSYLPVRPAMVMSRMLEAQEAMNLRPDSNAPIMDMNVKEKEEHIRNCLSRKLKEIFSLETAEEVIEEYPCCLMNSVLLQGYMYITKKHICFYAYLPKKSNEVVKSGYLYKSGRRNLKFHRYWFRLKGDVLSYYNDPSDLYFLRGNIDLRYGISATVASKENSKDAVYFNVVTHQREFNFKADSVASAKEWVKVLQKIIFQSHNEGDSVKISLPINNVIDIEEIQIIDFADTCKIRAVDNGDTYAVDEYFFSFFSFGKEALSLLRRVVEDTTAQHIPDEVLGISPNKKSDPGDEISSSKWNCGLSPKGKKPVSNSLPQIPNVPLLEENVRATLTLIENTTPRVSSEINQVSYDGGRRSLDQKSTARSGISPFRLERDVTKNKPKSPNEKIAKLNGEPLNNDNLSRTSCNTSATEGQILKSSETLFPPEIEQESQTISIIENKTDPLSNKTPVISYTRPSNDLAMEPLLDENECSVTTPTLQSIVKASAYPLQKAAGFAGYINKHSRRMSSLLATESIVYAEKVSGMWKGGKKHYGESHGLESEYLYEEGDNEDIISSIERFREHFSLPETEKLHATYFGFLNRVLPLYGKIYISDQSFCFRSLLPGTSTKLILPLIDIENADKENGFRFGYSGLVVVIRGHEELFFEFPQSETRDDCAVTLLQKLDTLRFLRESGQLAIKEEENAQNAVNEHLALQQVRSKRFDLNLSEKLKEKNIESAPITFDDPRASILNFKPNESLRVTCLTIGSRGDVQPYIALCKGLLAEGHQARIATHIEFKDWVESYGIDFKAVSGDPAELMRICIENGMFTYSFLREASSKFRGWIDELLSSAWVACQDSDLLIESPSAMGGIHIAEALEIPYFRAFTMPWTRTRAYPHAFAVPEHKMGGAYNYITYVMFDNIFWKAIAGQVNMWRKKQLGLYSTNLEKMQANKVPFLYNFSPAVVAPPLDYSDWIRVTGYWFLDEGTDWEPSKELTDFIDKAKKDEKKIVYIGFGSIIVQDSVALMTTIIKSVEKADIRCILSRGWSDRLDKKNAKKTEPPLPSSIIQIRSAPHDWLFSRIDAAAHHGGAGTTGASLRAGLPTIVKPFFGDQYFFGSRVEDLGVGIVVKKLNVSLFSRALWQVCNDERMIIKAKILGETIRKENGVDTAIQAIYRDLDYARSLIKRRSRKLTDDVLDDSEESWTFIGEEKDAELVLRLQNWKAKNVNKGNSPFNEREDDSDEGALQKNLIVENSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0W9</accession>
    <name>A0A0B1P0W9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002526">
        <property type="protein sequence ID" value="KHJ31863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0W9"/>
    <dbReference type="HOGENOM" id="CLU_1670682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="158" mass="18420" checksum="AE77620040808341" modified="2015-03-04" version="1">MSSVAQIIKFMKGAPKLEESSYDRWSTQFLDVLSIFDLTDYVLETKAELSNCQKKNILDMDRTTQKQDECIRIAICQLVPDNVYHLFNSNSTAKEWWDNLKQYYCPNPMNKLDLLLEEFWQLESNDTTSVDALVQQLSHIRNESIITDDSFCGYALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z3</accession>
    <name>A0A0B1P0Z3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative had-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002491">
        <property type="protein sequence ID" value="KHJ31898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z3"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Z3"/>
    <dbReference type="HOGENOM" id="CLU_020262_4_5_1"/>
    <dbReference type="OMA" id="RIWGFFM"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000089">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="29575" checksum="D7ABE622AE40B3A2" modified="2015-03-04" version="1">MANSKSTGISSHNILSANKITASSLKSPVFPVSPTSASITNKYKNIQSPPQPLLSLSQPIYAIQNGQNCRVMQKTLILDLDETLIHSMAKGGRMSTGNMVEVKLQTVLMAGENTSLGLQHPILYWVNKRPHCDEFLRLVCKWYNLIIFTASVQEYADPVIDLLEQDRKLFSGRYYRQHCTQRQGAYIKDLSSIEPDLSKVIILDNSPLSYMFHPENAIPIEGWINDPTDNNLLHLIPLLESLQYVTDVRTFLGLRGGENGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Z8</accession>
    <name>A0A0B1P0Z8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5872</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01003396">
        <property type="protein sequence ID" value="KHJ30970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Z8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Z8"/>
    <dbReference type="HOGENOM" id="CLU_038298_2_1_1"/>
    <dbReference type="OMA" id="EDCAGWK"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ30970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="335" mass="37629" checksum="8D9E27FEA1D2F0A3" modified="2015-03-04" version="1">MPVSSRSSYEALSNPPSPTRSCARRVKLTMLHSGLPPSPVDSHGGIFDQNSATLLEEKRLTREITRGTPGDKKRAMDIRSPHERDLARKRSQYYENAFAVDPKPAFTARDRVLRESFIMAEIKTNVIINDEYSLITDISYALSTRYQRPENSILVTLSHSCCVLFGGNSEPAYMLNVTALPSQVLPITNRRNAVLLAKAMEDALGVSAERGIIKFTSISEDSLAYNGRTVGREIEELERSQEESRKLGRCPSSRGTICSRRKPSIKSIRGYKAHQLHTHDETMISATPKPLMSKNHNHLSIPERSTGVLIMEHQNDRFQKMGRRRSFIASIFGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P121</accession>
    <name>A0A0B1P121_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002469">
        <property type="protein sequence ID" value="KHJ31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P121"/>
    <dbReference type="STRING" id="52586.A0A0B1P121"/>
    <dbReference type="HOGENOM" id="CLU_022723_1_0_1"/>
    <dbReference type="OMA" id="HESHNIP"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="492" mass="53381" checksum="67BBB3FFD65D3DBC" modified="2015-03-04" version="1">MVDYFAWLPIFLVRQDNVQREHTQYKRLPQRHTVSITQSQHAEIVAIESTIIQTEVIQRNAGAFATQAVMSTDFISNFKNISNPRVTLVAMMASSPIHQALPSINQSMLSNRVGSSLVTSSHSMGIKHITTEKPTPSPSTKAPSSNQNILALTSLVNSPSTFSSLNYNHNFTHFVSSPNIASGQVNSLSIVISTSSKFSFASLIAITSSLATSGIEHRVKTTASSLSFLPSESILPTEVMPTPTSINIIGVENAEPSSALNITSPTKSSSHQYSHHAPHAPVVVGSIMGSIAGVAVLVFLIMLFLRWHKSNKWMVPLDNEAIPGVPHSASRGHLSSNMTLQKPHNFSMPAALASFTVSKIMSQNKFRLSSSTNPDEKAFYRISGRKLPSVFQHGGDGYGDVAPPPNTDKSSPRNTKLQNSFVTSRYTSRSTLAGSHPSSSNPIIFPNQPLNSVRDSDLLQPSILKPPQRPDSIGRSRPSMDSSLTSRFTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P142</accession>
    <name>A0A0B1P142_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002171">
        <property type="protein sequence ID" value="KHJ32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P142"/>
    <dbReference type="STRING" id="52586.A0A0B1P142"/>
    <dbReference type="HOGENOM" id="CLU_011918_1_0_1"/>
    <dbReference type="OMA" id="KWEFEAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF130">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="336"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="612" mass="69570" checksum="6281F277160F8194" modified="2015-03-04" version="1">MGQSQSHSHSQSSDCKSYISKTQIRHELASKFAKRCFTSLELYTFQEVFKNLADQHNGDLSVSEKSIVEFLQIPHILGISPILFQMLSYIGSFPYCQDTLALVGFDEMIMIVVILTQRCQRVLRKENFYLTKLLFRSLSIHEHYGLPQQDVSLDMDETILQGKNMPLPRNEDAIAESDMTNEDLDGDSLALDALELLGTSHVFKPKEIPISKTSIPSDNLKKILMLLILIAPLGNQEYLSSYPERLVGDFIEGLRRTADNILAAFINVEKSPGVMFHQFETVISTSLPLLFKGFIPLFEHFLFSKNIDFTKRSNVITHPSTAYPDRDVDQPLQSSDILDLNILSQLSFFLPSLLSQKLRLLYMGSDDGFSLGSFATCVFNWRAPTILLVYGTRISDPPLRRQECLFVETLPPKRFPNSSKSNRLVFGVYLTEYWRQSYQKCFGNFETILFQLEPVHEVFNASLINNDYIAFNKRNTGYQGITIGCSYQKSQKNRQISGHSMDVDLGAVSLLLDSSFEFGVFNHDYTSGGGAFHNSQTRKFDWQDRFEVESLEVWGCGDDSDAKNQKERWLWDEREAEARRRINLGSGDIESDRALLELAGLINNNRSGGSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P149</accession>
    <name>A0A0B1P149_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003336">
        <property type="protein sequence ID" value="KHJ31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P149"/>
    <dbReference type="STRING" id="52586.A0A0B1P149"/>
    <dbReference type="HOGENOM" id="CLU_018649_2_0_1"/>
    <dbReference type="OMA" id="DERFIHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="610" mass="69248" checksum="67C7ED56911D26F7" modified="2015-03-04" version="1">MEVTKLVVNGREKPKVNGNWLAYRKQLTKRINNLRKKLGVATKPRAKCAGRVEVTKDDIAQDLKFGHLLLLTSERAWANAMSMREVHLGERRSITSSTRSHIISKLQKSTIYARNLLKVLQSDNICDANVNDVLEVRAYAATLSGALEFERHKWEISLKYYAESRIIYSTLAAATKNDIYQELLSDPVDPSIRYCTYQMQISRLLSINLIAQRYFPSSDAWLIAVIERLDSGALNNELAKSRSEDDIVPSTITWRSRTINIENSVIILALVSVQMAENKLSESLSVIPSTRTRERASAYDDILTALQDAVYATKHTIDQLSQEGISDDDQRIQDLQVIQTAINYDMISWRIDRNRILLGEGDGIYLENKNYQLAKDDTQRKGKISIQKRLVRLQEKVVLYDSILQSLNSIKDLAGIAADTSLLKDINSKYDYFSSLRCLSIARSHSLLFQNRNALALFFQASSRCNSAHAYISSIMDIEDPSMKISVSNSAVERLKALLNFETQRHRALVEFSNLIDTEQNCEDVDKIPLIERLSEFPSKGVDLSNLVVYPPVLEPSPVKPLFFDAAWNYIKYPGNEIYETDKITDQVKDSARDSDKGIVSKKRWFSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P183</accession>
    <name>A0A0B1P183_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003780">
        <property type="protein sequence ID" value="KHJ30671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P183"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="315" mass="34515" checksum="8118D529BED64043" modified="2015-03-04" version="1">MICATVISNVESTLANFTEEEEKEEVVASKAYIRLAIANYAAADSSPAPPKIPIHSKPVKGNRSSSSKEKNALKKVAIAIPQKIVPQTVEKSWATVTRNGHKKARVTQNIVNNQVAPVRKASQNMTNKNKSSSRTFLSVSIADTRLFFRLPQDHEWRKLSPAGIREIIVKKLHISPKLIAGNGLFLSGAKLEAAINWISVLVPTVPAFVHMEHGKVEVSKSMLNCGGPHRADSRRCLTRPTRAGVPTKDQMKTYRQAGEREYQAVQRARVAEEKAAITDKIEIDLVSDQIRGGIDTPENSQAAPVEDSTAVANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P190</accession>
    <name>A0A0B1P190_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative guanyl-specific ribonuclease f1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002123">
        <property type="protein sequence ID" value="KHJ32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P190"/>
    <dbReference type="STRING" id="52586.A0A0B1P190"/>
    <dbReference type="HOGENOM" id="CLU_029060_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="413" mass="47286" checksum="BD5DB7959E688CF7" modified="2015-03-04" version="1">MRRKVNNASLDNILQLIFLLDQGGIFHIVFKANSGKVIDVITRVVTNRQAKCTRIVNSRIQSSPISVVTNGYQCGPEFFSDEILQESLDIARSSRGKNPFFPVSYTGSLYPQHSGYLIWPIYRDNNLYKFGQSRLLPYFLVLDSEYNLEEVIVKGFQNNFLRCMRTRKVPKAPTSDPLSKLFVQPPKEGFMCNKVFFDKKYLERAANEAMATSRNRPEYQFPEKYNGHPFHKPCLLWPIKNSETMYVKGRPGQYRLALDENFAIICAVMMTNKIVKPCERVTVKGKKNHDASAYLCHRWVISSEKLISTVEAACERFSVKSRSAFPAYYEGPEFEIKGPYFTFPIAKDGIYTKGKVSSRVVFNSKCEFVGAITSVIRNSQRKLVKCHRIGSAPVPERMPIDLTEPINERHIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C8</accession>
    <name>A0A0B1P1C8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative f-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002389">
        <property type="protein sequence ID" value="KHJ32038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C8"/>
    <dbReference type="HOGENOM" id="CLU_556909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="580" mass="67600" checksum="90BAA95AD900C7A6" modified="2015-03-04" version="1">MNALESFETLRFPDGRPDIVRRRLYLNKLISRLMPSEIRYLKVHLERINLSRTGNDIFKEMPNEICLKIIDYLYLEDLLRIRLVCHLWHQKFGHLDFSLHILKRYFDMPMEFYFMRSSFNSTEVEDTQKSANWIQRFIINRIRREHGITCRRYLIDGLVVDSIRYCSSRIAFQNGEIIEVRDLISKASKTFMTPTREQMKKWLLSDKYLIGIVHNPTKLLAWDMESLIANTIRLPAEVLSISASQNRVGIVTSTSEFFIWIVGGALRKLPKYKHVKDSQEEKVLAANIFFHCEDQDNVFLVSYSRIKSDSFSDEKYVTKITVQNFVMGIPFLTQHKILYTSTKPLEYRSTLISNGNLIGIEILDSTSKNFYEHFTYDMNKKQFNCQEVALHPMIRNALHRRNHIIWRDQIFLPIFIGEVASVQAITISKSLIEIWNEPPNSNYKSSLSLVQSSALLGENRSNSTCVTLDAEFFLRYSNGIQIWADDSFIIIYDKRKIQVWQFNDEGLEPCHSVVTDNINQILQRPMQYVALHVLGSHEDSLNPSLQASHSSPWVSMVFVFTSLSPQHLFSRSPPRLAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1K7</accession>
    <name>A0A0B1P1K7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002322">
        <property type="protein sequence ID" value="KHJ32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1K7"/>
    <dbReference type="HOGENOM" id="CLU_1469268_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="21199" checksum="D1DCB05159CB5F94" modified="2015-03-04" version="1">MSNIGPSDLRGTQYHGNLYAPELSYWIYPITEKNRKKSVANVPEYTYYLVLTPTGEIKDVIAKLMHKDFMKCACTTKAPPVVSLDRDFKGSYRCGTKLLRLKFMKRTALHAKRYKQRPKHWNDFPKPYNGPGSCSGQSIFPILANGKFYTGAVGRKYRYFIVVNSNFEIEFAIMKTHEGYKLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S6</accession>
    <name>A0A0B1P1S6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001957">
        <property type="protein sequence ID" value="KHJ32602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1S6"/>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="845"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="935" mass="103790" checksum="13C33D02E4402C4D" modified="2015-03-04" version="1">MAQDGEHKNSIEKGKGSIASARSESIRKGKDGGKAVNGKEDDTIGEELSEEDQQLKNELDMLVERLTEKNSSLYKAALEAIKDSIKTSTSSMTAVPKPLKFLRPHYETLTNLYENWPVGDDKISLADVLSVISMTFSDEDNQNTLKYRLLAPTSDIASWGHEYTKHLALELGETYTKRLTADESTQDLIDLTLILIPLFLKSNAEADAVDLMSELEIIEDIPKFLDKDTYSRVCLYMVSMVNLLTYPEDQQFLRTAHVIYLKYGQLTQAIVLAIRLNDINLIESDFNSTNDVALKKQMAFLIARQQIVLDLPADTELDQDILDCLNNTNLPEHFKSLAKELNILDPKTTEDIYKSHLESTRVAGLTNLDSARHNLAAGFVNAFVNAGFGQDKMMMVDDDTKSSWVWKTKEEGMVSTMASMGMLCLWDVEGGLDKIDKYTYAPEEEIVAGCQLAIGIINSGVRIDSDPALALLGDEEKLHHQSSLVRMTSIMGLGIAYAGSNKEVLLDLLLPIVVDTSLDMQISAMAALSLGMIFVGSSNSDVSEAIVQTFLDDERGYQLKDKWTRFMALGLGLLFFGQQEEVDVILETLKAIDHPMSKPTSVLSEICAWAGTGTVLKMQELLHICNDYIEESEDKKGDELLQAYAVIGLGLVAMGEDIGQEMVLRQFGHLMHYGKANIRKAVPLAMGLLSPSNPQIKVYDTLSRYSHDNDNDVAINAIFAMGLLGAGTNNARLAQLLRQLASYYHRDQESLFMVRIAQGLLHVGKGTMSISPFHTDRQVLSRVSAAGILTVLVAMIDAKLFITDKSHYLLYFLVTAMHPRFLVTLDENLKPLTVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVLLAYGERAELEDEQYLCLTNNLEGLVILRKNPDWDDGKIDRNLKEFSAGKVEIFTFTRCRCKRPVCSACLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1U0</accession>
    <name>A0A0B1P1U0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dynactin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002239">
        <property type="protein sequence ID" value="KHJ32213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1U0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1U0"/>
    <dbReference type="HOGENOM" id="CLU_038287_0_0_1"/>
    <dbReference type="OMA" id="YKFGDWE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="434" mass="48591" checksum="93984CB2097B15E2" modified="2015-03-04" version="1">MALQLNRKYANLPDLDSAPDVYETPELTDDNSTTVGRARSESNASSRENDFAETDRCGISKSRLPFHEARLQFAPAIIDAQNVDFSDRLTAKRKSYKASSRNLRKRESDTLQLEDSSDEETESFGKKLARLKREVEEIKEISRAWAEKETTNQDGIVDLGADVSALSKALDEISCLQMTGRQSHISKLTKDLGSGIKVNRSPHRSQCDEEPATYTVTYAPVYQQSHALAKAANFDSRLAMLEKVLGINAVDELSLIDNGSRKAVIPSLEKLQKQVSVLSNSTPSSLDGISREIRKLTQEAQKLESARKAANIAQKTMNKDEELTPKIEEDSELVMKLNALYGALPVIEKMRPILPSLLDRLHSLRAIHASAATTKSALDKIDREQLEIADDIKKWQEGLSRMEKTMSEAEATMNSNIRFMNEWMKKLEENMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W8</accession>
    <name>A0A0B1P1W8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative telomere length regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003489">
        <property type="protein sequence ID" value="KHJ30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P1W8"/>
    <dbReference type="HOGENOM" id="CLU_235458_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1642"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1812"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1515"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1812"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1917" mass="216009" checksum="35A64A578D078C9E" modified="2015-03-04" version="1">MVSVINFQARKYGQASDRGPYDNCVSDLQSCSSDKKVGFLDTVQFNDHPSSSSFNAEQNCSRTGIRSTVSLAKSLPLKGILKPSNGYTQLSVKNMLQSHLKALAGSDIYSRSDAYVNLSNMIRAFDDTPDSQNLVNNISELGQYIERDLVAVNENGKPNSTLISQALALVISLQYNPSIAESFPTKFSIFLVEFAIKSLEDPLISRDIKKNVMFMMAHQNFSPKVITSERLRNLIISLNSPSDKIEGRNFFLRRLEIYRHLLKSSKSLMIVHTAWIGDLLCDMNSSLQAVQISAIKVGFQAAVELGSEASVTGALCTLFKSKLNDDELYGTTYLQILMNKARQKEQAVFVPQIWSVLILLQRYKSQILAQSSHMKSFLAALTLCFNQKDVKVQKQAQYAWNRFIYAVQLSEKTPKPMREILIRPCIQSILNRKSNHISGCFFNLLYYAFRPGCSTSQLDLYWDEFVIVLISQSLGLVESNRIIDRDVVGVVLKILVNIFDIKTPRRWTEKKAVESFGPNEISADELPALDSKWLRKNTTRAFSALLNILNRLFWDFSDPSSTATKVWENYINSVASPAAVEIKVSLETMSCISNIFEFLNHRWDSGIHSSISLSYLNRSQDSHEFLLSIQTIICITISGLGALSFTEKLLHLSQGKFSPVSSTHQNSLKTKILCRSPIAYLLIIFSKSCPGLEYDFKFGEMIDSVLKLVFEPRKNLSSLLELVIEIFQIIPEDEILIQLQVIWESLSKQLISSMVMSNSKGQKIDGEIFSKIVEVLKMGIKVSPKKPLRGWISLFEFVTNSISVQAGYSGGVIDILEPISEVLLQFPNELLYVETLISKVEYAKDLMALEPIHRKLCPIENLVMKNSSSYPCVQFYKYLKNSLIIAYDLNHENTDIISSTNNFLSRCPDEQILDVLIHLKDGIIPWIIDRESKLSNELQFNAVLLLWTTINSSLLRAVEYIPMKKKLHDLETMIASGLESKNRNIVEMTVETWDAIFSNFSGDLEYFKHLQNMLHSFRLTFSDSNNNSASDRSNISNKQAKEVEFENTDDQLDDKSLTIAKSKLNRENQRLSTSPKNAKISTPQVIIRIKNLSGNSQKEKKEPLKTCAKNPEIQMSDHTCYSIQPESEVSPIKHNFVSQKLTRNRRQKASSEDSEFTHGMEMKLSEESNEIGLSDTPKISISPSISDFCSSQQSISIEASKLDTTSDRTVLTNYVIADDVGHISSLNVTSQVIQHDLSISTTSFSSPVICSNESLRMSTNFENLDVTKPTVPKIQTPVKQHNKLHPQKSSSMKENTAIQSSLNKEIDNMEFAETQDTDTPFTYEGRVYNYSSSAESVDVITKANFSNVESPEHGKSPYRINVKTKSLKEKENENKNNKYLINTQELYCMDDISSDETSLPKPTRLQGISSSPVSLTYSSSRLNLKPNIIKRRTGSLSPSFQFTDDSSAIQSYKSLSKKSLSLLNHKDIGKDKNLNPNLTFEILGKDPKKLMALAKTLAPYDSLKQPPSPLKSPSRTEFFNESQPPSKQISNTENNQFKIESPKKGTLARHQSNEILGSGRISRSLTRKRKLSVDNKKAHHIKGYIEQESKEQLNFKRRKTCKDSQVKDIIDHEKLDVRPGISVNNEISDDYTRGTRLSKSFPILNTKKPDSKNNNQNSLNCVSNAGYSENNEYKKPYRRSTRSRVIRPNRSPVVTRNLSSNSKKTLTLTKRLKQRSTAKNSLRKEKKDVDARIFSTSLTNLQQQLEKLESSEPSHFSEDEFDLGSNDKSAVNACSVKNELSNYPNFTSRSNPKPHQRNDEKSLIMISSFSTTSSSSSSAFTTANSNQISGSESNKSTLASNKSANKTVRMSQNPPIHSPVSNHNNFCRDIILGKLGLLISAINQAELRKADISLIEDKMMDAKRALYEAERRGRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Y8</accession>
    <name>A0A0B1P1Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipase b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003456">
        <property type="protein sequence ID" value="KHJ30926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Y8"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Y8"/>
    <dbReference type="HOGENOM" id="CLU_029537_0_1_1"/>
    <dbReference type="OMA" id="AMCDESP"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062540" evidence="1">
        <location>
            <begin position="16"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="492" mass="53001" checksum="BB0900A9E7BF5D9B" modified="2015-03-04" version="1">MRVTLLLSSALTVAAIPAAFDSNFLKSSSTSRLTSNGRVMLATDANPSGNAADNDYNSVPSSFRDENNMVGHAKYVSGSIANGTITEKDAPSVIQALFMAATPTSTPTSIPDTMARANSAFKMQNTSPSGNSTEPNLMASALDMMMNGLVTPETHNNILNKAAVPTFNNPPVPAEKNFYTKEGNAPFSLPEEQLRSAIQIPPTFTYGQKQPVLMAPGTGASGYETFGNTMGKLLATTPFADPVYISIPGNLLNDVQINAEFVAYALQYLQAMTNQNVAIVTWSQGSLDMQWSLKYWPSIRNITTDFIAISPDFHGTRLAYLLCTGNQNINMIGCTPAISQQAYNSRFINRLRQNGGDAAYVPTTTVYSQFDEIVQPQFGRQASGIIREGNGVAVSNNLLQDVCRGQEGAGLFLHEGVLYSSTAYALVVDALTHDGPGSIDRVRSTCSQTTPEGITDLDVVQVEALIVVILFRVLTFAPKVVREPELKEYATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Z9</accession>
    <name>A0A0B1P1Z9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Z9"/>
    <dbReference type="HOGENOM" id="CLU_028621_0_0_1"/>
    <dbReference type="OMA" id="KVVFRWK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="432" mass="48785" checksum="DA1FECDDA9341F42" modified="2015-03-04" version="1">MLDENLPCYSLKPSTSGNPLIFSIFLGENGSEPRVVYNLQKLDLSFTDSKGCYAIGLVDPYNLGILYADVKVEAEWTQPTYSSIEVRAQDGASTALVPTVPESFIIQLYNPYQQITVKQKIGIWSTSAYWKFEIPVESFRIPSSSLLDQTQNTNAPALSNQTPCVTFKWKRDGKISKNITCYMVVKNDDGKRRKEPDITIAFFKGGKGLTLYEPNLRRVEIQDQKGFEIILLLSALVIKDIFFNPTKEIFNISSSKDATSGLKTKFGTLEVSRMNNSTPMIISDSSSSNSNMLGFKSNVIPQILNPNVSSWLQNSRDTKSDIDQETERLKKLIAAEEKSRKDAKEEEERRTREMLRAEEEERRLREAKVEKETEELRKLYGTESISSLVASPKIESKPCKMGSKLVPTPLRISPVVTGWLETRRKLSKSNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2D2</accession>
    <name>A0A0B1P2D2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001802">
        <property type="protein sequence ID" value="KHJ32817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2D2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2D2"/>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="OMA" id="MHRIMVT"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="44786" checksum="5DCD28376021826F" modified="2015-03-04" version="1">MPGYPGERYNGGNGGNGGLLRHAFSWGSNHFHNSHGSQEPSNRYSYQPAPMPSSYQQYHYVQQNWDNQRPNMYHNGNFRPPPPPPTNMQYFGHGAPPDYAYQYSNCSGRRKALLIGINYFGQKGQLRGCINDVKNMSEFLSQRYGYKSEDMVILTDDQHNSVCQPTKANILRAMHWLVKDAQPNDSLFFHFSGHGGQTKDLDGDEEDGYDEVIYPVDFRRAGHIVDDDMHNILVRPLLAGVRLTAIFDSCHSGTALDLPYVYSTQGVLKEPNLAKEASMGLLGALVSYTQGDLVGVASNLIGLLRRATIGENAHAKTKATKTSPADVIMWSGSKDDQTSADATIAAKATGAMSWAFITAMKKNPHQSYVQLLNSIRDELATRYSQRPQLSCSHPIDTNLLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2G1</accession>
    <name>A0A0B1P2G1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003568">
        <property type="protein sequence ID" value="KHJ30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P2G1"/>
    <dbReference type="HOGENOM" id="CLU_000901_0_0_1"/>
    <dbReference type="OMA" id="GSTDWPA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="4">
        <location>
            <begin position="1488"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1832"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="903"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1850"/>
            <end position="1861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1881" mass="212934" checksum="7A086212B5499B2A" modified="2015-03-04" version="1">MSSNGHAPDGPDRAIILSGPSNSKDEDITKECRILTVEQAIPYSPFSSIVPFDSDIIPMPSIGLRSSNSIFKGSYPLEESRYGLENLNREAADPKNSSGNLQRCLSYVGELLHPAGITRYKFKVKPKSCTNSSDSQEPQIFLSAFTQMVFENTYLSFTNSNSDSYLNSRKSFDLLRSSPSLSLSSRHQPLSSYHVRQHNPLLGVSTRNIIPQVIIPSKLSERKQKSYSEHITSPHLTSISETKCQLELNQKNSMIKNTSGDNISNFTSDPQINSSTDSSSLKISNIPITQQPVISSNLIQKSNKPDRGLLKSVGKLKIQDNKIPSTKSDAPVYPENIIPRLEIGSHNDNLSRECDERERADTALRNLQEFLQEILEVENQLDTDTVNQFFTYSHEHGIRLTVSTHIKLDSLIQKAIQLGRFSKVEVSDLIRVQRICESTLKDTESLDLKIHDRMSEEDVKLWSLQLTSAQLSIRSAYTALRIMSGSREERQIYSEDLTKSALCAFSYVLEVCVIPILEIRNFGSFKNLFRLLLGEKKIVISLFKQCQRLLLLLATLVPQVDLADSVMNALESIIFKIFFVENVSSEKDSIIGTSRFDRMRTAAMEVLLGIFTSRPAQRRGIFAEFLTSLEKLPISKQNARQFKLSEGGIIQHASALIMRLIQTNTIRLDGEKESRRMMILNDIIPNNKIITDYKHDCVISSDSKDKYETNSTTKINHLKVIVAPLLKAAKSDATYVIEFIVNRATTTTKGIESPYRHLLDFFVQDFITCLGSIDWPSAELLLRFLLFKMIEISKSPKASSISRNMALDVLSQMGPKISELNFQAQKMVKSVEYYQNELGNNLAKLMELFFEKKESDAQTQKFDSEILSWSHGPFRVCLESLEDRSSENLVSDSAIAFIKVDWANRIIESFDRIEDKNKELEKNYEILAQRIQGVIKDDKWFTREYGFNNKPTSTEIRLAHTLILLSSPFCQYLDHILSIFFTSMNSGQAMVQAKSLKCLTQLLDTDPSIIERHPWVKDQMVARLEDISSSVRENALGLVSKLIFLRPSLEIEMVPEVLKRLSDANVGVRKRAIKLSKDIYIRNLKHHVRVRIAKTLLWKTADDEPSIQELARQTLEDIWLSPLHQSAANNDISPQFKLDRAELVSLIVETTETPDGMLDKLLADKLDKALTNILSSTSKSYEANATVFKALVESMFETVIDNSSGASNGAQSRIGCFHILQIFATSKPELFTIEHIQILHPYVANLSNTDNAAIYNSVVNIFKQTLPHLSGIQENLLITIRNDLLKSLARLRVAQLDDVIACMSIISKTLRNFDNLTRVLISGLETINKLKCSELKEDHALKKLLKLLPIVGLLGKHCDFESRRSELSKKFPLPQYGTVSRLITDIIAPLASKSYPLELRKSALQALGYVCFSWPQNFSYMNVYSAFEQAFDEKQVELEMVVLEAFKSFLLSEEKRSELEQENPECISIDVKANLGVMGGSQGDGIALSIAQRFLQRIIFVSLSSREEKLTLLSTEIIASVARQGLVHPKQPGVALIILETAPFMKVAKIAYDEHIALHAKHETLFERDYMTAVQSSYDYQRDIVNDTRGAWISNDNEISGTSYVSKLSRMIQVLNDFSKPKTRKKFFENICLQLDKNKPRKDASEKHLTSREDEDHMRFSQYLVENIAFFDYKTFDELISIIHVIEKLVSSMGTDVAHAIENDVCMIPLHNPPLSNENNENFKNSFEDVNFIRLKQLTAASIPLLLLWEVRSFLRQQHGLISNKREGRAKVSKDLTIKPSKIAGVNGENFWQQSNVISGALKSEESMKDQCRKFVELLNFDHELKVAASSDDDSIEPRITPEIDEENSVPRTLHTSGITQSKKRKFFNGTLSPNHKKHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S3</accession>
    <name>A0A0B1P2S3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002714">
        <property type="protein sequence ID" value="KHJ31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S3"/>
    <dbReference type="HOGENOM" id="CLU_1058431_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="263" mass="30187" checksum="D5CCECD3200B6B03" modified="2015-03-04" version="1">MTSNVKDIPIHTKRVTRSLSSQSKSDNSKQNDNLPLLNSDIKRLIIDKSCDSHLFSKNILDTSSHKPQSLSPLNTSISHLDSDLLERSTSGSSSNETTVFSPNQALDISRCPCYDVTKNHPTNPSWANFAAFHNHLISTPKADERLFSFLADLVSDHLFQAQTVISLNSEIEFLHQQQISLEENRSSVQDLKIIMQQKEQDIQFLKKEVIRNRNDTLVWKNRCTKLESELKEKNNELVMIRETVRVVCNVLFKLYLDLYTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P302</accession>
    <name>A0A0B1P302_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002641">
        <property type="protein sequence ID" value="KHJ31705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P302"/>
    <dbReference type="STRING" id="52586.A0A0B1P302"/>
    <dbReference type="HOGENOM" id="CLU_050091_0_0_1"/>
    <dbReference type="OMA" id="SGIAVCY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926688" description="Protein BIG1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35640" checksum="71E578AF124C2E0D" modified="2015-03-04" version="1">MKAFLSLVLASQAVALSLAPDLELSNRNYNIGSVANGFADSIGEMKQRRQLSTSTGQLGAMGMNGQNATQWDIMTQNMCIETIKLTKSQVSNPSGMSICYNLPFLDERTGVFQADLRVFMVNPPSGPFRTISTDKIQVGLSYSGATVSPLNTSALTRRMIDGTPFLTLPKSVDKLTMKRETTPTMIQRYGFVGEINKSLLPSNPNDLENILTPNVTLSAVDSTGATVTTSLNSDETKFVNGVFAKQEKLPTKALLAPPIQTLVVAPDAPFVVPGLNILIFPIGLIITGLWTILMISTIGYGTFGRIQWREQFREAKLRESRGSLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P334</accession>
    <name>A0A0B1P334_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002626">
        <property type="protein sequence ID" value="KHJ31730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P334"/>
    <dbReference type="STRING" id="52586.A0A0B1P334"/>
    <dbReference type="HOGENOM" id="CLU_028692_0_3_1"/>
    <dbReference type="OMA" id="EIRYRRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="32504" checksum="743F59CE349544F3" modified="2015-03-04" version="1">MASRHTVKICAQARAGIISSDTINCVIPFQNAIKYQTATTAASFAIITVRPLSYQPQRVIYNKAPLLDTKPIFNSAKPSISPKPALSSGSSMTEEQPQIKDISSGLSDEPLDLSKESDQVDWTRSFHGLSSQPFSKEAAEILMAPLDLDDIEVKPDGILYLPEIKYRRILNKAFGPGGWGLAPRGETIVTGKSITREYALLAHGRLVSVARGEQDYFSPEGIPTATEGCKSNALMRCCKDLGVASELWDPRYIRKFMKANARQVWAEHVVTKKKKQVWIRKDDEVRYPYKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3C6</accession>
    <name>A0A0B1P3C6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative u3 small nucleolar rna-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002880">
        <property type="protein sequence ID" value="KHJ31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3C6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3C6"/>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="OMA" id="PYVQRHF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="680"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="7">
        <location>
            <begin position="733"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="911" mass="100772" checksum="1774E3AC858B1894" modified="2015-03-04" version="1">MANKAPYRTTFEVAETIKPIYTGNGVSLDGSGSILATALGEDALLTHLDTGRQLAKIEGDGELISTLTLTPSASHLIICSRSLSLRIYSLRSTPDRSCPIKNDLVRTLKPHTSPVTVLAVEQSSTLFATGAADGVVKVWDIIRGYTTHVFRGPNVLISALHFFEIKLSSKHEEQGISARNLQNRKKGKVEEETKNESLKGLRIASGSQDGKVRIWDLYSRNCASLLDSHVSDVTCLDFSPEKNILLTGSRDKTIMWWDVKTWKIRKVVPVLELVESAGFLEDGIYTYTGGSIGNIRIWNTEDGKEITSPQSPKGETNGIVKSIIFKDFIFAVKTDHTMTLYSSAPLKNITSLNLIDPLPIVRKISGTHDEIIDLGYLMPDNSLLALATNSEEIRIVSIGGEENNAENPNYFGADIAQLTGHEDIIICLDIDWSGHWIATGAKDNTARLWKIDAANDSFTCYAILSGHAESVGAISLPHQIPPESSPAFKLPLEYPPQFIITGSQDQTIKKWAVSTLQTSLSARKPPKAVYTRKAHDKDINAIDVNYNSQIFASASQDKTVKIWDLNEGEIQGVLRGHKRGVWSVKFASQEISNIANISGGVSGKGLVLTGSGDKTVKIWSLSNYTCLRTFEGHSNSVLKVCWLTLPKPDNRKKYVQIVSSGGDGLVKVWDVNTGEVACTLDNHEDRVWALTVNSRTNMIISGSGDSTVTFWRDTSDFTQAATIAAANQFVEQEQQLQNYINAKSYREAITLALQLNHPGRLLALFTSVITSIPEPDSLCGLRAVDNVLSSLTDDQIYNLLHRLRDWNTNVKTAPIAQKILWTLMKSYPSSRLSHLKRLGSQSSRLVEGKEKNIGFLDNSNQQQQNSYYNTKEIWHALRVYSEKHYKKLDELIDASYLVEYTLKGMGTLDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D1</accession>
    <name>A0A0B1P3D1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative duf6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002570">
        <property type="protein sequence ID" value="KHJ31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D1"/>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031581">
        <property type="entry name" value="Csg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16965">
        <property type="entry name" value="CSG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="53215" checksum="F9AD322B786C5B8E" modified="2015-03-04" version="1">MRRPPPYSEFQLKSLSHPREYDANNPTQNEPTTSNHSVYGEVSEEPENKHMGNKRPSYLLTDTGKLLEPLLTKDSNDEDEERGDSGSLSPTLSSRTPSSSEGSSLRSISPDKSTELESITKYRYAAFFLGLSLISFVVQTETAVYIQHELGWNKAYSMLYLTHSSWCLLWPLQLLVAKIQQWDVPWKVFLARNIQVLRTTAQMVETQQPIISRTQHSPVPYLIRTTTIVTCALTVAGGSWYIAVNLTSPSDLTAIYNCSAFFAYAFSVPMLGEKLRWDKILAVVVAIAGVLVVSYGDSVSTKDGGKSGGAVGGGDAQDKEAKNRVVGNLVIGVGSVLYGFYEVLYKRLACPPEGTSAGRSMLFANTFGSLIGIFTLCFLWVPIPILHFIGLEKFELPHGEAAWLLVVSILSNSIFSGSFLTLISLTSPLLSSVAALLTIFLVAIVDWLWTGIPLSPAAIVGGILIIIAFATLSWSTYREMSVRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3D3</accession>
    <name>A0A0B1P3D3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="JNVN01002568">
        <property type="protein sequence ID" value="KHJ31810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3D3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3D3"/>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="464" mass="53873" checksum="E356D78CE8BBCC2D" modified="2015-03-04" version="1">MWNRFWNWSMASRIPKEPTLFVLGATGTGKSSLAVDLAKRFNGEIINSDAMQMYAGLPIITNKITYEEEQGIPHHLLGNVQLDEEPWRIGVFQREAKNIMRQIRARGRVPIVVGGTHYYIQSLLFRDSIIGEREADDSDHKLGQESIDEFPILNGPSERILEKLKEVDPLMAERWHPNDTRKIMRSLKIFLETGERASDLYARQQEYRDKNCQDSSKIDFFGENISPESTLLFWIYAEPEVLKKRLDDRVIKMVETGLLDEVKSIDQYLEKQLSNGIKIDITRGIWASIGWKEFESYRLALKTGTDVENALNFSIQKTQIATRQYAKRQLRWIRLKLRPALAWDHGWSRRFYLLNGTNISKFKEDVTDIAIKITADFLANKELPLPQEISSTAKIVLSTDDKKPNVWFRQTCDTCLITSMNEIEWDSHLRSRRHRALVKKRLKKMERRGSRDLDLSNPSTSDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3G8</accession>
    <name>A0A0B1P3G8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002521">
        <property type="protein sequence ID" value="KHJ31870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3G8"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31173" checksum="5EACEC0051BAF596" modified="2015-03-04" version="1">MSHVATTVTENAKTLTCQNELLAVVEAEKQAALATLATGSQNNFVVSLKVYLRSAIAHFQRSGTVATPPTLPSYPTGPPPAVPIIKNAAKSVLPAKFHTSQAAQNKADVTWATIAQKGHQKSPAIAGLRQNVSIQRCSKSDERLILRIDKDHKWRLLAPSGECEILCEHLNFIPSDLTYVTRTSTGFALTIKEKEIRQKLLNDSDRISFQGAKLEPASDLITYRIATVPVARRTSSGSVTVDDTNLVAEIIKVTNVAPKMVRVHGKTRSGAPHRSWLAHFSREQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L0</accession>
    <name>A0A0B1P3L0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative impact family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g3097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002816">
        <property type="protein sequence ID" value="KHJ31536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3L0"/>
    <dbReference type="HOGENOM" id="CLU_045276_0_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="9">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Impact N-terminal" evidence="8">
        <location>
            <begin position="259"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="411" mass="47061" checksum="A3F850C4FE4042C4" modified="2015-03-04" version="1">MTSDFLGEEHEEENETLRDEIIAINSIYGQDTIRPMVIDNKQKEKNIYILHLPHLRIWLQIKFSPNYPYCCDNDEQQKDDEQGSNDDRSTQVMVVPPIRALGTHGCGSMVRKGDATQICQKFEQLARQLYRPGDVCLFDIMEELMNNGSSDCKSNEYSNRNENNIKSLLSSKEKEFPSDDFSTKQTSFSALEDMEKISSIVASTSSKIATGAQAEATDFEKRDKKMKGKNKNIQEDKSTAQQQMKTPKWFISEPIRELKSLFLAHCTFIHFVNDVARFRNLLLEHEDKKKLNSATHNIMAWRIRYHDGDNNGIVVHRQEKKSIIANSTSKFKNLNPHRYKIDEDYDDDGESAAGARLLHLMRLMDVWNVLVIVSRWYGGVNLGPRRFAIINSVARDAILKATASSTPSKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3N0</accession>
    <name>A0A0B1P3N0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3N0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3N0"/>
    <dbReference type="HOGENOM" id="CLU_050129_0_1_1"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079703" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="37540" checksum="063AC1EAD81588B5" modified="2015-03-04" version="1">MIGLQFPTIFAFLASISLTLASTLPSKNHHTFEENSPLPLIIWHGLGDNYKSEGMTKVAALAEVVNPGTFTYIIGLEDEPTSDRSMSFFGNVTSQIEQVCADLAAHPTLSTAPAVDAIGFSQGGQFLRGYVERCNAPPVRSLITFGSQHNGISKFQSCNDDDYLCRVALGFLRSNIWTNIIQNYLVPAQYFRDPSKLAEYAYFLASSNFLADINNEREEKNETYKQNLASLKRFVMYLFQDDETVIPKESGWFSEVNGSSVIPLQERQMYKEDWLGLKTLDDRKALVFKTVPGRHMQLSDDELTKVFTKYLGPLNRKFDEEIEIGIEHTSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Q8</accession>
    <name>A0A0B1P3Q8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001727">
        <property type="protein sequence ID" value="KHJ32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Q8"/>
    <dbReference type="HOGENOM" id="CLU_001324_14_4_1"/>
    <dbReference type="OMA" id="MACASET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="37167" checksum="2DC128B5BA2CF098" modified="2015-03-04" version="1">MPGPAGTGKKFLYKTLCNKYRSEGKVVLCAASSGIAALLLPKGLSHSLFNTPINSNEETQCRITGNSDLAGLLRRAHLIIWDEVTLQSRHDFAATTDDRNIFREFIYPQDQLSAGDVSIFHDRAILTSRNDEVTSFNNTIAGLRATESHEYYAQDKVQNEEARHISDYPAEFLHTLGGFGQPLGRLTLQVGMSVMLRNLYPKMGLCNGTRLIITRLSDHGVRGRVISTATAFHGREHYIHRIVMTTDENLPFTLSRRKLPLRPCFSMTINKSQGQTLQQVGVDLPTPVFSHGQLYVTLSRVTDVNKLILLLPRGSRKTTNIVYPEVLMRPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3R3</accession>
    <name>A0A0B1P3R3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002751">
        <property type="protein sequence ID" value="KHJ31591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3R3"/>
    <dbReference type="HOGENOM" id="CLU_030378_0_0_1"/>
    <dbReference type="OMA" id="VSAQTHF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="418" mass="47002" checksum="F23076300553EAD7" modified="2015-03-04" version="1">MQQTPIPAKLKEADLTRFINRATQLENIKPVIAYWCEYWIVNQILTKGLHNGDPETLEFTTKLIDKLEQIKAENPEVDAILDDKAGQIYVLQFTLEIFQRAEKALRANKATKQTASTFQAAATFFELINIWTTPEHDILAKIKYSKWNAVRILRAISEGRDPNISDSKLETFQNQNLTLGEPENKEAEVNLSTEESLNDNTHLETLGPGIQLKTSELNSPTRSWPKTLVSHKENQEQISDHCSSRDPSPENGSPRMESEANINEIYSNIDSLPEVPVTGHTFSILSPERINENCDFDPEASNDSSEQGNFLLGRDFESFPAPKLSDGAFESAQNSKNVNLSESKLFSETHSITELPRITPTVVTDTLNIEQRVQPIIDDISIAKAQKHARWAISALNFEDTETAIKELKEALKTLGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3R8</accession>
    <name>A0A0B1P3R8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pci domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002748">
        <property type="protein sequence ID" value="KHJ31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3R8"/>
    <dbReference type="HOGENOM" id="CLU_084512_1_2_1"/>
    <dbReference type="OMA" id="CSAQRNT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF3">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079710" evidence="2">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="19239" checksum="1EF7F21B4333AC17" modified="2015-03-04" version="1">MLLSFTTACGLFAGYVIAQSMNNSIPFNPATVSPTLRAQWCQGQTNTCGTLCSGNLKENDCDPDTLNYSCHCGANNSSPGLQYYKETMPTFICEMVFDNCIKAGENSQAAQALCTENEKRDCGHLSPEDFVGVAPTSSSAPPSPTTTGGVATSSAASGAAVTNISPRNIETGALAIGIIAALALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3T2</accession>
    <name>A0A0B1P3T2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative tsa family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001505">
        <property type="protein sequence ID" value="KHJ33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P3T2"/>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="183" mass="19865" checksum="E00BC365C1771936" modified="2015-03-04" version="1">MSSVALFRRLATRSYIPQRSFHSSTKAFVKIGERIPDIDVLVEDSPGNKVRLREVIGNDKALIIGVPAAFSPSCSNSHIPGYIKHQKLKDAGKVFVVAVNDPFVTKAWASSLDPNKSSGIRFLGDPTAKFTEALDLAFDGRAIFGGLRSKRYALQIDSGKIKAMYVEPDNTGLNVTAAEKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P404</accession>
    <name>A0A0B1P404_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcription initiation factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P404"/>
    <dbReference type="STRING" id="52586.A0A0B1P404"/>
    <dbReference type="HOGENOM" id="CLU_078004_0_0_1"/>
    <dbReference type="OMA" id="GEFDMTI"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="221" mass="25166" checksum="0FB930A85D03162D" modified="2015-03-04" version="1">MVAEVKRFVKVVTEQRNIDKPSEVEGFPMKSWNIEIYLLDEAGNERTANCFTKAVYNLHPSFANPVQTFTSPPFRCENEGWGEFDMTIDLYSTEKGGKNSITHDLNFSKNRYEAKHQVTFKNPSVALLNILRESGTVPGDENGRKSGTIKKKKGIDMDKLAEGLVKLREDDLLHVVQMIHDNKSEDTYTKNDIDQGEFHVDLYTLPEPLVKMLCDFVSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4K5</accession>
    <name>A0A0B1P4K5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ser thr protein phosphatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001315">
        <property type="protein sequence ID" value="KHJ33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4K5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4K5"/>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="OMA" id="KENWAGE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="1">
        <location>
            <begin position="131"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="42247" checksum="D51E09EA815B3FF7" modified="2015-03-04" version="1">MALKEYELQTIYQAIRSQNKDTPIQVFGSHTHIRNFVKYDSKAAGLQSGRYLETIGWASINGVKNNSQFGAADEVSFHRRYIDNNILGYRYHTGLSASEFPTEHGKNTTSFIAKARESLNLDHKYGCVPRDLYYTYSSYPKNDSITTWTLDELLPGIVKTKLQRAKTPTFLMLKSVVMRSDLLKGPFTRDSAFIFVPYEQNLAFIRNVPYKAAMEISKRGSWDLKIFDEKPLNRTTNKNNQLQSRELGTDSVHRNSQLFEKQKSLIASKPLTLVRGYTTNDDGGSDGDDTLHSPLGRFAFPPPILSSVVGLPSKGEPEYVDLFFNKPLTSMMLILLNNMGLKFDTSNVKDHSDELIRDIISQWVKENWAGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4M0</accession>
    <name>A0A0B1P4M0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002219">
        <property type="protein sequence ID" value="KHJ32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4M0"/>
    <dbReference type="HOGENOM" id="CLU_1579670_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059354" evidence="2">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="18230" checksum="B13648441549932A" modified="2015-03-04" version="1">MPSKSIVWICSVGLIWQLVMPQSFAVPLPLNAKQNHIASLDVRSTVAEKIHPRFAGAILGGLATTVVGNALGGAISPVFQKIGEKMGGSNNEPEPVIEEEQTEEEEPVAKTKISKAQKVEETETSTKLGNTSKSEKLEISEAGEKSTKSQKSKELEDLEEFENPELSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P531</accession>
    <name>A0A0B1P531_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ldb17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P531"/>
    <dbReference type="STRING" id="52586.A0A0B1P531"/>
    <dbReference type="HOGENOM" id="CLU_017272_2_1_1"/>
    <dbReference type="OMA" id="ISLRHTY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="458" mass="53191" checksum="EBFF8BC87BA28451" modified="2015-03-04" version="1">MESLEYTLENQEQFWAEIEDILSAKDSSPRSINNVLRTFIYFVQKLGSEYLTTQENYDQCLDKVLECKLFSTNMDKVRLLVMDCLMRDENPISLQILVKFLLQDGRRNDATFNVMKHKGCFPRLVKLINSDQKKDKALLSLLLNLLYEMSWCQQLSTDDLRQVSDEFVMNLLNMIEELSNDPEDPYHYFVIRVLLVLNEQYMIASTMPHKDSRFLTNPVVKLLSSNGSSFMTFGENLILLLNRETESSLQLLILKLFYLLFTNQATYEYFYTNDLRVLLDVIIRNLLDLPTESNSLRHTYLRVLYPLLAHTQLNQPPYYKKDQIMNVLNSLIAKRNAHWEPVDETTIRLVKRVANVSWLDKLSSKAIDVEVRTTIPDEIESPELHLDRNIIGPNTHLNGKVLRSSLPNDEKSSNERPRPPPVARSRRNVPTQGSQVRQVSTTKRSPLPPIPTQRKTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F5</accession>
    <name>A0A0B1P5F5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dnase1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002278">
        <property type="protein sequence ID" value="KHJ32161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F5"/>
    <dbReference type="SMR" id="A0A0B1P5F5"/>
    <dbReference type="HOGENOM" id="CLU_120092_0_0_1"/>
    <dbReference type="OMA" id="PCNNAYY"/>
    <dbReference type="OrthoDB" id="3513524at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080493" evidence="1">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="170" mass="18697" checksum="AD4BC138FD2CD82B" modified="2015-03-04" version="1">MIFFWTFVFLVQISFSIANSVHFVNQDAIARTIVFTSAKGQPQLSSIKLMGNSVAQKNFPFGWSGNWYSVSEGAADVPGMLGEVTFDGYDGATYFDVSAIVNSNDNQGVKQLFPAGINKPISGCQSFPCANVYRKADDLQTVSTYSKDLICLLGNNQNNLRRGIRKETKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5R2</accession>
    <name>A0A0B1P5R2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">EV44_g0189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002226">
        <property type="protein sequence ID" value="KHJ32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5R2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5R2"/>
    <dbReference type="HOGENOM" id="CLU_022833_0_0_1"/>
    <dbReference type="OMA" id="SHYEYAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="40406" checksum="EF59161B0A5A5E56" modified="2015-03-04" version="1">MKFNILSRFIYVGLYAFLNIILAVLLLVTPGDAIRQALDNNQLYNVFVISGSYFMTLLLAFILYASRLYTDSVTLKAIPKTWIPVESGDVNKKVRKMVLASLNRSALIAWNSRPRTSQEQIKDSSELPNRASSDQHTNLDQSKKIRHVRINSEKSDNAFTTVPFYPVWGEIVHDGWSSPMSSDFPNLQYITVILELPLLIEAKAISLASKNKARSSISHSAYFRAVEILKRRAAMGLREYINHLCKLNVITTPNMVHEFISLYEYSRFSAKPLSEQEFTELMKHFRQILQSMQSLNFEVLNSDKDLADDYFEDDSDLELSLKSSKSQELTPMDSIRGNSDSESNGTINRVYSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5U9</accession>
    <name>A0A0B1P5U9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002378">
        <property type="protein sequence ID" value="KHJ32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5U9"/>
    <dbReference type="HOGENOM" id="CLU_1826727_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="15554" checksum="7C0352A5097D5098" modified="2015-03-04" version="1">MLYKGKTRAGVKCNSMFYKQSRIAAVAEKACRDVYARQGLVLETNPLAKYFRSTVKDFPGPASFFPQATGNKLTMVPITKSFFSPSRIKTFLGIRKKDYMVFGGTCTSLGIVREQSKNNFILCEAVNGGSVAHSPVEPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Z9</accession>
    <name>A0A0B1P5Z9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01002166">
        <property type="protein sequence ID" value="KHJ32331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Z9"/>
    <dbReference type="HOGENOM" id="CLU_036100_1_0_1"/>
    <dbReference type="OMA" id="VWILASC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="441" mass="49042" checksum="2B07FE58F0593F15" modified="2015-03-04" version="1">MDPETNITILKSNILELPPSCIEFAPKVVDEGVEYLVVGTYHLHNEKTENLAHSLGPNQQSREGSLILFKISNKELTLIRTIPYPSAILDLHFYNGHNTLAVASSTGTISIFHLVKRAEILDLQLVATHQVAHKDILVLSLAWYPYTNALQTGFPRLLFYSLSNGHVLAAGLSGDFKSFSILNNGTPLIIHDDNAWTCTAASKILLSGGDDSMLRMARFDLHTPHDAENEFEFETILIDGSKIDPKDRSVTQSYLEGHNAGVTAIIFLPSPSTFNDDSFILTGSYDDHVRIFKSTAGLWPKMSGVRKLTELLVGGGVWRLKLMEAYPLSSETDDQAWEYIVLASCMFAGAQILKIKGSYHGSWSIQVGAEMKIHQSMCYSCDAQPQRFSSEEEQRDLSSEGPAKTWTVASSSFYDKLLVLWEWQDGSMAHWGNEGTEESKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P607</accession>
    <name>A0A0B1P607_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 18">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">EV44_g4883</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 18">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 18"/>
    <dbReference type="EMBL" id="JNVN01001032">
        <property type="protein sequence ID" value="KHJ34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P607"/>
    <dbReference type="STRING" id="52586.A0A0B1P607"/>
    <dbReference type="HOGENOM" id="CLU_000395_1_1_1"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="25">
        <location>
            <begin position="38"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="24">
        <location>
            <begin position="156"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="26">
        <location>
            <begin position="572"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="23">
        <location>
            <begin position="1109"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="21">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="22">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="22">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KHJ34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1188" mass="130269" checksum="16BC258886F490EC" modified="2015-03-04" version="1">MAADHGPNGAYSEVFEDGIDIVQPQTIHRIRANSSIMQLKKILVANRGEIPIRAHELSLQTVAVYSYEDRLGMHRQKADEAYMIGSHGQYSPIGAYLAGDEIIKIAVQHGVQMIHPGYGFLSENAEFARNVEKAGLLFVGPSPKVIESLGDKVSARAIAIKAGVSVVPGTDDAVGTFDEVKKFTDKHGFPVIIKAAFGGGGRGMRVVRSIETLKESFERAASEAKAAFGNGTVFLERFLDKPKHIEVQLLGDNHGNIVHLYERDCSVQRRHQKVVELAPAKDLPQEVRDNILNDAVKIAKFVNYRNAGTAEFLVDQQNRYYFIEINPRIQVEHTITEEITGIDIIAAQIQIAAGATLAQLGLTQDRISTRGFAIQCRITTEDPANGFSPDSGKIEVYRSSGGNGVRLDGGNGFVGAIISPHYDSMLVKCTCLGSTYEIARRKMLRALVEFRIRGVKTNIPFLASLLTHPTFISGECWTTFIDDTPALFDLVGSQNRGQKILAYLGDVAVNGSSIKGQIGEPKLKTEITIPTLYDEDGKKIDTSVPCQKGWRNILLEKGPEAFAKAVRQNKGCLLMDTTWRDAHQSLLATRVRTIDLLNIGKETSHAYSNLFSLECWGGATFDVAMRFLYEDPWDRLRKMRKVVPNIPFQMLLRGANGVAYSSLPDNAIYHFCEQAKKHGVDIFRVFDALNDIDQLEVGIKAVQKAGGVVEGTICYSGDFLNPKKKYNLSYYMNLVEKLVALKIHILGIKDMAGVLKPKAATLLVGKIREKYPDIPIHVHTHDSAATGVASMVACANAGADVVDTATDSLSGMTSQPSVGAVLSSLEGTDLYPGLDVHKVRAIDTYWAQLRLLYSPFEAGLTGPDPEVYEHEIPGGQLTNMMFQASQLGLGAQWAETKKAYEHANELLGDIVKVTPTSKVVGDLAQFMVSNQLSVEDVQQKAGELDFPGSVLDFFEGLMGQPYGGFPEPLRTNALRGRRKLDKRPGLYLEPLDLAKIKQDIYNKYGSVTDCDVASYAMYPKVFEDYRNFVNKYGDLSVVPTRYFLSRPEVGEEFHVELEKGKVLILKLLAVGPLSDTTGQRDVFYEMNGEVRVVTIDDQNAAVENTSRAKADPGDSSQVGAPMSGVVIEIRVKEGSEVKKGDPIAVLSAMKMEMVISAPHAGEVAHILVKEGDSVAGSDLICRIVKPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P653</accession>
    <name>A0A0B1P653_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002281">
        <property type="protein sequence ID" value="KHJ32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P653"/>
    <dbReference type="HOGENOM" id="CLU_089389_1_0_1"/>
    <dbReference type="OMA" id="DRMGGLK"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="176" mass="19835" checksum="5A002C0F398DB2A4" modified="2015-03-04" version="1">MAKLPIRNITLLQARNEQHNSSTMINLLITLLVLIFISLILTAVLLVARTIRRRRALSRHYLASPETNYTQNHQHLSMKTTFSRSSSYSIYEEKKSPLNTSSSLSSESVPEIRITFPDEQDESGRRMSGRVVVVRVGEAGIGLEPLRDEEQLPAYEEGGGRFHSIDIDQIGGLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P666</accession>
    <name>A0A0B1P666_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001255">
        <property type="protein sequence ID" value="KHJ33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P666"/>
    <dbReference type="HOGENOM" id="CLU_2456436_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="89" mass="10071" checksum="EFAFCF992249B5FC" modified="2015-03-04" version="1">MGIARVVLNNSTQVNPTGRQSHRPANKEKSKILASQSVVLSDTRLFVRLPQDHEWRKLSPVGIRKVIVKKYKSHPPSLEKLSLYTQVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6J4</accession>
    <name>A0A0B1P6J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001173">
        <property type="protein sequence ID" value="KHJ33878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6J4"/>
    <dbReference type="HOGENOM" id="CLU_078295_3_3_1"/>
    <dbReference type="OMA" id="VHLFEDC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005729">
        <property type="term" value="C:2-micrometer circle DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043505">
        <property type="term" value="C:CENP-A containing nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030543">
        <property type="term" value="P:2-micrometer plasmid partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061644">
        <property type="term" value="P:protein localization to CENP-A containing chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000088">
        <property type="entry name" value="Histone H3-like centromeric protein CSE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="128" mass="14840" checksum="67F5261B47202471" modified="2015-03-04" version="1">MRKRKSHAKSEASIQPGDPLPREKKRRYRPGTLALKEIRKYQRSTDMLLLKLPFARLVREVALQVRPAEEGWRWQSQAIQALQESAEAFLVHLFEDTNLCAIHAKRVTIMQKDIQLARRIRGVWGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W3</accession>
    <name>A0A0B1P6W3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002109">
        <property type="protein sequence ID" value="KHJ32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W3"/>
    <dbReference type="HOGENOM" id="CLU_567648_0_0_1"/>
    <dbReference type="OMA" id="CPERINS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="481" mass="52960" checksum="0C6B74023598F1BE" modified="2015-03-04" version="1">MIAQAEESNELLLSETESQKSLPTESQKIGMVAYSCLPYTSHDLKRKLPEGHLYASTSRYNLKTPRNGNLKLKSCFTESENGSETKSESCENASLDQSLQNKVTTPKELIQSNITPPRRSRCDVSSDITLIEPSSSLLSKAAFKSLLSTPGYLTYQYGPNKNVLATPLSPQTNLCATPTALSLKSPFSCPERINSSIPGSSPRMRLSQSLNGKAELVTEKSPTPKIQIACPRTSSGNKSSFEKKGKLQRSKSAPGSCTHQTGIGCSNASLRSRRANGRSRDARSWTYFCDGKSRDDFFRQIENASLGSAVAAISLIRSADSPSKILNHKCEILPTKDYRSSLQATDKSELQHITSSSFKLSAYNHDCVKDCMLTSPCEDSDKENWLPLQNGSPCRLLPSSRQNKLLMPTNMTFNNHNTDLGIMKGRKRKLNDSFVNVSRDRPQLEIVRRVGFFGNGDKNNGKTGDIGAIQGLLSLRLGNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W8</accession>
    <name>A0A0B1P6W8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01002107">
        <property type="protein sequence ID" value="KHJ32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6W8"/>
    <dbReference type="HOGENOM" id="CLU_000288_19_1_1"/>
    <dbReference type="OMA" id="LRWIHRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000997">
        <property type="entry name" value="Kinase, AGC NDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="126"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="501"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="673" mass="77730" checksum="BD266146302DCE3D" modified="2015-03-04" version="1">MSGSVVGESSSLENILTPIVEDVNLEVRAPESVPKAFVTVERAAIAKIFLERYYEKLYSCHITPRSIRRHQVELFLYRNQSLSALEKGEIRQSLARDESEHLRHLRVMKSRKRNSIKEQDIVSSAYDVIKILGKGSFGVVRLVKEKYNDLNVFDSNQDPQRKRGNVCAMKVIRKSNMLQNSQEGHLHAERDFFVAAEGSRWIVPLITSFQDMENLYLVMEYMPGGDFLGLLIRENVLSEPVTKWYIAEIILCIEEAHNLHWIHRDIKPDNFLISASGHLKISDFGLAFDGHWSHDQSYFNNHRYSLITKLGLKVDGDSIDKQEGNTVAAAMKTAQMMMSGKVRHEVDTAVSTDSGGDLNWRNKNSNRSFARSVVGTSQYMAPEVVRGEIYDARCDWWSMAIILYECLYGHTPFIAEDGSRQQTKSNIVNHRSEFKFPQRPVVSRKCQDFIRSVIQEKENRLCSRKYRIKESQGNGKHIKDPAGQYVYPNDAEDIKAHKWFRDIQWDRLHLMIPPVVPKLKSLDDTCYFDDEGSVSDFSESVSETPYSQEDIVNILEPFNSEIKTLTQEYLELPYDSTRLKEFEKKIDQFPIVDAQKQNLKKLVKLNGRKERKRPRDILLRDKSIGPKVLKIRKEGAFLGYTYRRFNPGQYNVGGIFRRNRSSTFKRSKINCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P757</accession>
    <name>A0A0B1P757_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002029">
        <property type="protein sequence ID" value="KHJ32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P757"/>
    <dbReference type="STRING" id="52586.A0A0B1P757"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_0_1"/>
    <dbReference type="OMA" id="CIFTHDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="304" mass="34750" checksum="012EC642DB56E8D9" modified="2015-03-04" version="1">MSKCFNTKNLGEMEMFLGMRITRDRKNRTLWLDQQQYLERTLTKFGIPNAKHRPVSIPLDGYENLTPPSGDEERIDPREFSMIIGSLMFAMVYTRPDIAFALGRLSQYMKEPTKKHGYALKKLMRYLRYTVDYRLRFSPKETVTLVVYSDADWATDKVDRKSISGGLGMLCGAAIFWLSRKQRSVSTSTAEAEYASASIVAKLGQWMAQVLRDMGYPEYVAPNGITVETRGDNQGALALIKNPHLNDRSKHIDICYHHIRDLHEKHRIRTEYVPTKDMLADGLTKPLGKGPFSNFVKMIGVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7G7</accession>
    <name>A0A0B1P7G7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001940">
        <property type="protein sequence ID" value="KHJ32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7G7"/>
    <dbReference type="HOGENOM" id="CLU_090424_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="239" mass="26104" checksum="250CB33CFDDE59D7" modified="2015-03-04" version="1">MINSDHNFPSSPTPLRAGASDHLLSKSGRLHPSLLTIANAMQQLETERRERMGLAQEFLEIIDAWTKGKTGSKARQDQRQGLLLPLPKKPGGNRKETESNDSKEDKRIFLGLRPDHAWRKLSPLAIKRMITEKAGVAATAITELCSLRSGYAIECVSDALRDTILSFGKSLGDTDAIIEAASDWTSELVPNVPLSIRTLDSNVIVTSEMVANECLAVCGMLPIQLRPMKSSIGQFILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7L4</accession>
    <name>A0A0B1P7L4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001716">
        <property type="protein sequence ID" value="KHJ32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7L4"/>
    <dbReference type="HOGENOM" id="CLU_769862_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="40670" checksum="BB710047D34128DA" modified="2015-03-04" version="1">MDDVLVRLLMINTKNFEKDWFSWFGLAKEFRSYKASAVSITPEVLNIDITPIARQRKIWKLELSLESFLAICHSRFEMSNSVPDSKSPLFPSSSSTAPIEEKCASEIAEISCNAIHSESLHGKKSRSSSVESLLGDRSGTKSHLNVTKIAPGDLKTDHLKLSAGLENFSDQNSPHYTTNSKSMASPFALSRESNHNRLPSLGEIHQSVEEEQEAQVNRLLQMIHIEQQNLWHLRNANDYLNTHTNSDEAVIAPTHHAPLSPVRNSQNISCSLDTKMSLCSIDNNDRSDAHPNSTSSRRTASLGQAMTEWKEDGESFAWSFRDDPTVYQAESQMMTRENQMLRRRIRELEMQINELSPDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P801</accession>
    <name>A0A0B1P801_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g4384</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="JNVN01001624">
        <property type="protein sequence ID" value="KHJ33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P801"/>
    <dbReference type="STRING" id="52586.A0A0B1P801"/>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="417" mass="44465" checksum="411DD5FF9D7963BF" modified="2015-03-04" version="1">MSLSNKLSITDVELKDKRVLIRVDFNVPLDAEKKVTNTQRIAGAIPTIKYAIEHGAKVVVLMSHLGRPDGRVQEKYSLQPVVPELEKLLEKKVKFAQDCVGSEVEAIVNGSTGGQVVLLENLRFHAEEEGSSKDAEGTKIKASASAIEEFRKGLTALGDIFINDAFGTAHRAHSSMVGVKLPIKASGFLMKKELEYFAKALESPKRPFLAILGGAKVSDKIQLIDNLLGKVNSLVICGGMAFTFKKTLENVKIGDSLFDEAGSKTVGDLVEKAKKNNVEIVLPVDYITADKFAKDAKTGTATDKEGIPDGWMGLDCGAKSIELYKSAISKASTILWNGPPGVFEFDAFSNGTKQTLDAAVEAAQNGKIVIIGGGDTATVAAKYKVEDKLSHVSTGGGASLELLEGKELPGVSALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P866</accession>
    <name>A0A0B1P866_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative histone promoter control 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001802">
        <property type="protein sequence ID" value="KHJ32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P866"/>
    <dbReference type="STRING" id="52586.A0A0B1P866"/>
    <dbReference type="HOGENOM" id="CLU_012566_0_0_1"/>
    <dbReference type="OMA" id="MREDEYD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="493"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="650" mass="69367" checksum="B68A7234B96FF64D" modified="2015-03-04" version="1">MELPVAYTPRKPVEFGLPRSPAQLSSEGLSSPPRSSPEALSPSRRVVNKILPSHAPSTSLPIVTSSVPSTAKPDVPSEKPPPSRKPRRKLKDLSAPSQPVTSKGHSLPGLAATATATTDESEAPKPKRIRKPKDPNAPPAQRRKKNITPAKVNEDDADAKANLALKLQPPSSKIKSDSNLAASQGTQLNTTEESQYPVQSFFSNASLLHSQAQPQPQSVRKSGQKYDPIRSSNYDPVRETVVRHNSSTNTHSFHSKSNTVGNASTTPSISSLVDPQNQPQSSTPPATQSFFNKPLSKSTFSDSQPASISANVKARDFSTKVSEISKQITSTTISKKAEAVVPSSQSKKNNANTKASPASPKQPKPKDMKEINNAIIPAPPPLPGMGNEFSNINDYRAPTVILEIPLNGEVNKYVNFTRLAEQQYGWDAIHPRLAAQRDRLARVAAAGAALERNGSGKDSGDEMSLDSEAEGSNVEMGGMSDGRAGPDCAKKVPKKRKMREDEYDKDDGFVDDTELLWEEQAAATNDGFFVYSGPLVPEGEKACIDIKADGTAKRGRGRGSRGGAARGATTRGGGTSANTSGRNSLPTSGPGSRGGIGARKPRVTKADRARMEQEKIEREKIVSVSNSSDPNTTAHSKTSTEGSPMVLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8G8</accession>
    <name>A0A0B1P8G8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative homoserine o-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001557">
        <property type="protein sequence ID" value="KHJ33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8G8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8G8"/>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="OMA" id="LGGCQGT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="493" mass="54199" checksum="F390D0E276C49248" modified="2015-03-04" version="1">MAETPMSTASTFSAPQRFIRVYEQPENPFASKVSNQIIAIIPSFTLESGVTLYSVPLAYKTWGKLSSDGDNVIVVCHALTGSADIRDWWGPLIGGPGRIFDLTKFFVICMNSLGSPYGSASPVTYKDGDSKKGIYGPEFPLTTIRDDVNFHKLLLDELGVKRVAAVIGGSMGGMLVLEWAYFGKDYIRCIAPIATSGRHSAWGISWGEAQRQCIYADPKYNDGYYSFEEPPSSGLGAARMSALLTYRSWDSFEARFSRKPSDVSKMTPALDFDSSSPGDIHLAIHNDGHISKQSLNNSTPSKTKTNKGERPVSCPLESKDQNANDSVPKLSPKIEHVKSPALTHFSAQSYLRYKGTQFAKRFDANCYISISRKLDTHDLSRSRSSSITEALAMIEQPALVLGIESDGLFNFSQQEELASAIPNSRLDKIDSIEGHDAFLLQCEQVNTLVLRFLHEVIPDKMQSKCDAQIGQISLETVVGEGLSLVEEMDNITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8I7</accession>
    <name>A0A0B1P8I7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8I7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8I7"/>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="24246" checksum="D723F37DDE308C46" modified="2015-03-04" version="1">MAQAAPTVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFSTNYGNIQFDVWDTAGQEKFGGLRDGYYINGNCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPSLEFVAAPALAPPTATVDAQLLASYQQEMEEAAQQPLPDEDDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K2</accession>
    <name>A0A0B1P8K2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative e3 ubiquitin-protein ligase hula</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000568">
        <property type="protein sequence ID" value="KHJ35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K2"/>
    <dbReference type="STRING" id="52586.A0A0B1P8K2"/>
    <dbReference type="HOGENOM" id="CLU_016272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="547" mass="61039" checksum="291DBCDD7B565917" modified="2015-03-04" version="1">MVDTSTCVLETYPGASVKRKRSLSEDEYFSWTFDLHESKKHKNLGALITPISPLDIKHNNMANEIDPISRSNLIANTIESQFSLEILLKHKELRLIDQELAKCQVDLEQLRRCHLIAHPGNLESPEATPHNGNKSCPFYQDKDSATWALPFGDTDGPCSRQDSKLLIRDPGFEGMAWKNINTLVPDKNMPIAHSVRRNDIHNIAREGKTGLRGKSSQKHQALSLERNQTKDRIGPCIVKRGDGKTVKLVCLDCDRENFLSAQGFINHCRIAHQRDFKSHIEAANASGQYMKVNETNGLIRNHKDPEIISDLVHPLIRNAPTGKEAKEACKTLLARLADSKAMLQNGKLPGFSSLPNSESPHSSLSKHLFSSSSKPYLSDLLHRKGLPHNLDNIVEELYQQIDIEELPAEEESTDSERSGANIETQTGDSYEFKKSSLTRISMPTHKDLSLSSRARDKSAEHIKGVKKLEGTLPKTSSCYSALDLVSQYETPTNSPCQLLTTSDPQSEHITELNLVKYSHSSIDLSPHTAKIYNAPSPVSDGEFNDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9G3</accession>
    <name>A0A0B1P9G3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sin3 complex subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000631">
        <property type="protein sequence ID" value="KHJ34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9G3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9G3"/>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="OMA" id="AKFYQLY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="815"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="892" mass="100762" checksum="3884D4F1151FF131" modified="2015-03-04" version="1">MYDRFTISNDNAYDLDKDREEPSVAFEVMSRSDAVKKNLERVVISSQGKAMSGFSQTQKLKQFVFTDPVAFRYLEEDPATVVYERHRILEGYQLYLVEQWACSRVHPTFVINTYTGDPDDRIIVGVLGVPAEEDTWSTRLRLYFNATSKMYARLQETSIGTIMVTNLNCFPSALTIIPVPDGDVRRHRYSFLVNENLKRLGCSGRSGISLSSPTGATQAKFFQLYKTSIRVPFCDAVIELVKLCQVALIVFGKLEQEYADGCLCDITEAAITEWWTEIGSEHYDTEPSDGILGPTTVAGLLGMLVGSRNRLNACGAPVGKDPFDLYHLKRGIEHFQKSQKLRRTRRLDRHTLDRLHKITAKAAAGEGWAVPKTVKSTVAELSGKGGEMVLGIVGRDRPCIGDVETLVIDDFINLASGERIKWLWHGKPKRGVTNETQSLPFVRDDSATLIWSPSKSEIEQVEEESDNRWKEEKSPLIFYSRHQLGSMHSSPDSPGDRDHLHRTVLKSVSGKMNDARNGLGRIKGAVGLRGYTHRHSKDESATSGNSLLSSSLTPASANLPSPSLSSKISTWKEIPARYQSGTPQLKESPCRSESQVDDINSENYHTENLANLPNFQNSKLHKSVLLDKDPVWAIDCKKNYSSIPLKSISLTGSSEEVELEQPIFEREQELKSYKFSLQRRNSISGGIGTLEKSRNDYWWPRRMSFSTAEDALLCWEPITTQNFYDEENRWSSLSGTNSTTENLRRLLQILLGLQNNDKPWVENKLLGLIKIDKELLQDQDNLQIVYGQLMHQYGMMKHRFQEVLGSEHTHILEDGKEIENLRAKLEYEINGLESKVFDVDDGVIQLERQVVELEQRADELETQLNKGSWKSWILRSIIGIRAGSGLFLPAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9H6</accession>
    <name>A0A0B1P9H6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prenylated rab acceptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001098">
        <property type="protein sequence ID" value="KHJ34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9H6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9H6"/>
    <dbReference type="HOGENOM" id="CLU_866527_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="36338" checksum="B471449DA7539A73" modified="2015-03-04" version="1">MALWDENLQDINENTKIDSGDIDLKNDGVFARDLIQPTDAELESIQSGSNNLNELGDSSHSDDSETDSNILEPIEKLLIQLALVRIRRARQKGKTHVKLNKEEIAALEKRKRILHETSVMKAKRKIGTSDNRGSQTSSKSINIPLTSSFISDHLEPSHELEIPSDFNEQSNILNSSSFVLKYPSNLMSSMESSDDNFPSLHNSVNYHLSSTSRPFIGDRNYSHEPQSFSSRGIPHYANHGPNMPVGSSERFIPHLDPSRYQFNTDNPLTPKFVTTPYKYPINLDSKFPPVQPTSLEPNMNITTTRLRWRVRDSKDESSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U7</accession>
    <name>A0A0B1P9U7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001046">
        <property type="protein sequence ID" value="KHJ34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9U7"/>
    <dbReference type="HOGENOM" id="CLU_1310915_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="24799" checksum="6FF4690AF0B744F4" modified="2015-03-04" version="1">MNSQPSEPDKWPLKSTSDLWQVLNKRYILLDTSQTAKNALDTLFQDRRAYGDFKVDFDHFADRAKDDNRTKVDLLTKRQSRKISNVMDNQINLPGPDDFLGRSDMVDSIARNLQQQDHIFKLQTPQTATHQNVAITNQPLSDIGPSDIGDPMDLSRVKLSDAERKYRMGNGLCIACGEYGHSARDKHRKNNSIPIPMPKRPSTHPPNRTHTYSISALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Z0</accession>
    <name>A0A0B1P9Z0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative plc-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001017">
        <property type="protein sequence ID" value="KHJ34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Z0"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Z0"/>
    <dbReference type="HOGENOM" id="CLU_037358_2_1_1"/>
    <dbReference type="OMA" id="YYFETPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079860" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="32014" checksum="415E14A03E80F653" modified="2015-03-04" version="1">MFFFVYFILICHLKFAESQPCNGNEALCSRKYSDVTQIGTHDSAFVGDLPTQNQIYSVSEQLVSGIRFLQAQTHVKDGALQMCHTSCQLEDAGTLLSYLSTIKYFLDMNANEVVTLLLTNGDRTPAASFGMAMESSGLAKYAYVPPKKLAMNEWPTLKELITANTRLVMFLDYGADTSAVPYMLNEFEYFFETAFDITDANFTSCALDRPGGSNGAGLMMLVNHFLDVDLFGGIVIPDREASPRTNAATGPGSIGAHADLCKQTWGRKPNMILIDYFGNGDAMAAQNTLNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA12</accession>
    <name>A0A0B1PA12_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001002">
        <property type="protein sequence ID" value="KHJ34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA12"/>
    <dbReference type="STRING" id="52586.A0A0B1PA12"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_1_1"/>
    <dbReference type="OMA" id="VERCWRI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000113">
        <property type="term" value="C:nucleotide-excision repair factor 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070911">
        <property type="term" value="P:global genome nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="442"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="783"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="864"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1032" mass="117244" checksum="3C2EEAF0BAB778C2" modified="2015-03-04" version="1">MAQLSNEDAKQKKHDSTAATVHDTASPPLRRSTRNLPAVIVIKDSDESEDDLSLHDRRTNSEQTKLPKINEIDKSPNASASGVCINSTYPSASATININEANNNNLVHGEGPYRKSIDASKLLEKNVSVRRNSNNNSKKRKRVLESDEDTAHESSWRKQNHEASEITDKCKKKVRVEIKEKVLPLDTRIQLGSEKALNPRDNKIFEPQIPTENLHFASSSSRSSAKSKGKEIVTLNRDEINSGSPGCVNKTLFEQNNEDMEIQSDSNSLFSLLKTRSRIMNKKRSPQYINPSDPNNMTQGIESSTLSPNLLSVSSDAEHNTDSDHDLSAPVDYEPEIFSDEDLPLSDTSPHSYGLGTQILRQNQIPERTPNATRAQRRTNSPKEDRTVRERNRIEHFHPEFKTMWEDLEKIPKIGDVTMKQPDNINRELKPFQLQGVAWMKAMEKTKWGGGLLGDEMGMGKTIQAVSLIMSDWPAKQPSLVLIPPVALLQWQQEINSYTDGTLKTFVFHGTNTKTKAITKSDLMKYDVILISYNSLESVYRKQEKGFRRKTGIHKENSIIHEINFHRVILDEAHNIKSRSTGAARACFALKAKHKWCLSGTPLQNRIGEFFSLVRFLDIRPFICYLCKQCPCSILNWNMNKDHRCNCCGHSGMQHISVFNYELLNPIQKYGNSGLGAKAFQKLRLLTDRFMLRRIKRDYTTAMELPAKEIHINRQFFGEEENDFASSIMNNGTRKFETYVAQGVLLNNYANIFGLILQMRQVADHPDLILKKDCDGGQNVLVCCICDEVAEEAIRSACRHDFCRECAKNYVRSSENPDCPQCHIQLSIDLEQPDIEQDDAVIKKSSIINRIKMENWFSSTKIETLVHELYKLRSKNMSHKSIIFSQFTTMLQLVEWRLRRAGISTVMLDGSMTPSQRQASINHFMTDVNVECFLVSLKAGGVALNLTEASKVFIVDPWWNPAAEWQSADRCHRIGQCRPCSITRLCIEDSVESRMVLLQEKKANMINSTINSDESAIENLTPEDLQFLFRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA36</accession>
    <name>A0A0B1PA36_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="JNVN01000519">
        <property type="protein sequence ID" value="KHJ35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA36"/>
    <dbReference type="STRING" id="52586.A0A0B1PA36"/>
    <dbReference type="HOGENOM" id="CLU_018580_2_0_1"/>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="528" mass="60280" checksum="3B6FB7F2C7CD90A2" modified="2015-03-04" version="1">MGFAPTSIPPGTAAFLTQETENRLWTPLFKKDCTFPPETFHIVMRNLVQNPNINSTYLFRADILVDLPFSLGIETQLEGQTLRVVHFKSFQLKKVILRTLIPRNIRVGKPLDQTCLFYENKLNSSKTISLVVYLPHISCESESPFYHPAVYGISFLHEFCQATQMGEVSIHYCFFDSEPRSVKLERTAYHLLATLYKHGQGTAAGYIKRVHHDVILPQNIVQNTYSRLKLKYSRKLIENWVESTDPTKHVFEDLGIAAFLIELWNEIYKDKKFPGFVDIGCGNGLLVHILREEGYTGWGFDARYRKSWSTYSKLNQENLKEMVLIPFLIDSITTCIPEAIDASEIEALSSCTSSCTWDSIREKMMFDSTTIRKINRDNPNLEIHSGIFPKNVFIISNHADELTPWTPLLATASQSSFIVIPCCSHDLNGARKRAPYVKNHFNKCSSYALLVEWVSQIVMDCGWEVEKEVLRIPSTRNTAIIGRTRTQSYEAIDLKFTLEKHGGASDWVKNTLKLLSKSSCKSNNSRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA59</accession>
    <name>A0A0B1PA59_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g3239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001229">
        <property type="protein sequence ID" value="KHJ33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA59"/>
    <dbReference type="STRING" id="52586.A0A0B1PA59"/>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OMA" id="GLMCAFD"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="484" mass="54402" checksum="4FC74E98509C0DA6" modified="2015-03-04" version="1">MRRFHRFVPKTARAVTLKEPLFFPDEPQKPIIKTTIPGPISKTAIEIEFDPILDTRSFVLLADYEKSLGNFIADRDGNLLLDVFAQIASIPVGYNNYNLSRAARTEQMVDAIINRPAPGNFPSYNWASIIKSGILKVAPRGLNQVFTALSGSDANETAYKAAFMYRRQQERGGRIPEFSDEELTSCMLNQAPGAPKLSILSFTSGFHGRLFGSLSTTRSKPIHKLDIPAFDWPQAKFPNLKYPLDENYQENEKEEAEAIAEVEEIIESYHVPPCAVIVEPIQSEGGDNHASPDFFRKLRTLTKKKNVLLIVDEVQTGVGSTGKFWAHEHWNLDTPPDIVTFSKKAQAAGFYYGNPDLRPCQSYRQFNTWMGDASRALLFQAIVDEIESKNLVQNTAIVGNYLYNGIDSLAKQYPKEILNLRGKGLGTFIAFDSPRRDYFLRKARSIGVNMGGCGERSLRLRPMLVFQKHHADILLSAFEDIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAK1</accession>
    <name>A0A0B1PAK1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative omega-3 fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000927">
        <property type="protein sequence ID" value="KHJ34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAK1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAK1"/>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OMA" id="QLFGWPG"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="51544" checksum="12BACB38FB4A01E6" modified="2015-03-04" version="1">MEKPQHIDLNGDPFELSSFTMKEIYDAIPPHCFKPSTIRSVAYVIRDYFYLSVLVYLAVTYIPIIPYTPLRFLAWSAYTVLQGFVFTGIWILAHECGHGAFSKSKNLNWTLGLIMHSFLLVPFHSWRLSHAQHHKATGNIERDTAFVPKLRDEWIKEKLGTKASENLIELAELAEDSPISALWHDIVHQLFGWPGYLLFNLTGQKYGGAKGLRISHFYFGKDSVFYKENELGLIILSDIGVAIMIAALVIAGQLFGSWNVIILWFVPWLWVNNWIVAITFLQHTDATMPHYSNSTWNFARGATATIDRDLGFIDTHLFHDIIGTHVCHHLVSTIPFYHAGEASVHIRRVMGKHYKSDTKTPFWTAFWRNQRSCKFVEESKGCEGSGVYMFRNLQNTPNGQAISKKPIDRGSEKSEKKEELKSVISSSINIETRRRLSQSAQLRANLPILAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAR0</accession>
    <name>A0A0B1PAR0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001258">
        <property type="protein sequence ID" value="KHJ33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAR0"/>
    <dbReference type="HOGENOM" id="CLU_571061_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="527" mass="58073" checksum="4FAB13BBD125CB9E" modified="2015-03-04" version="1">MASNFEMLDGESEIHLNTEALENLLDKANRRLLRHRDWLANLPRDTKFIPTIVHPPLSLVTAPPNLLPRQNPQPLPDCNDISRRAFEAGANSATVVFSASISGISATITSLNIALASAQASASVALSSATSSLLMAQLSMNSAVSAAERSASIMVASAVDSVASANAAANEARAMLANEIQKAEASIASNNQAARASIIASQTAAMNTTKFALSLTFAILGSSIVTIISFYLIMRLRKRRTEKRQAELKEKIHIRNTTPTVFPDEFLPRNLPSTENFKQPRTRVSQFEAPRQLDTSRQFDTPRKSDAPRQPESPRQFEAPRQLEAPRKTDVLRQIEVSRPRLSQLDTQTHEIKPKYDAFTSENIMVPISGREDVVNPLITLDSENEIKFSEYIGGENKKLSSNQEKIGDVTRSIENNALVQRSDSMARRHTEGFGKKGSETDIFADKHMTFSPSSSKSSKPPRSRKPTLQYDPERPRDPPTFLDDSKDDDTGSQSDDLSPNSNLRPRKEDHSQKLMDGRISAIGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB32</accession>
    <name>A0A0B1PB32_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative trna-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB32"/>
    <dbReference type="STRING" id="52586.A0A0B1PB32"/>
    <dbReference type="HOGENOM" id="CLU_005382_2_1_1"/>
    <dbReference type="OMA" id="PDIKIYM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="45160" checksum="D417BB1415E27F39" modified="2015-03-04" version="1">MKCLSHDKIGQTQGVTLHDWHAEILAIRSFNHFLLKECLALVNTPSLSLNNNKNQEKITSKYLRRRTENEKTEFHFQPFALRDGLTLHMYCSEAPCGDASMELTMATQIDSTPWEMPSSQPDKLHDNQSSQLQGRSYFSNLGSIRRKPSRPDAPLSQSKSCSDKLTLKQFTSLLSSITSLFISPENMYLTSFVLPTSQYHKVACERAFSATGRLKLLQKQSDIDFGQEISSNRSGGYHFQPFSVNPTSLEFNYSRRQLLLHLRENESLVASNLASYSTPYIIGTLIGGSLRGRKQFSIKGAPPMCKHQMWQLAVELASKIGVKSLLQALGSSNIKNSRISIKTYNEMKCTELLSHRRNVKDQIRSVLGGDAGIKGWFRNIGGEDWFLRDLSREKAAKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB72</accession>
    <name>A0A0B1PB72_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative mitogen-activated protein kinase-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001162">
        <property type="protein sequence ID" value="KHJ33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB72"/>
    <dbReference type="STRING" id="52586.A0A0B1PB72"/>
    <dbReference type="HOGENOM" id="CLU_005113_0_0_1"/>
    <dbReference type="OMA" id="ASYYTWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114693" checksum="955CBF6B6B14CF2E" modified="2015-03-04" version="1">MSSTPLSRSNTGNLKLTPNTSQCLRGIRSPNKLRSLYESGLSLKKVIGTTVSSPTAFDALPSSRIFAYTAGATVVVVNTKDDTKFVQRYFIARPTPILPNTASLSPATSTVILCDSKSRILGGTGRENTTYSCISPYAIQDSVDLTTPKPWTTRDRIKSITCLALSFDGNLLAAGETGYAPRVLIFSLNNESPDSPLIIINEHSNGIRAVAFSPDSKYLATLGNTNDGFLYIWSINQKTNTAKFHSSNKCTSFIKRMLWMGDNKIITVGTRHIKIWRLTDEQRSVSPTKQRRKSDAISITISSQLSPKTLAGRNVLLGPLVDVTFTALAKISDNRALVSSEKGDLCLIDDTYGPKLLNLTNTGFSITCIAVDLKTRRVRVGGKNGRKLSIGLDDLLSPNTPPTSPIPMEELSASASTNICAMGFCGRRLVTIDTNHLIEISKLDSYDPDPTIQSTYFSSHSNAVLGLCMIDDNPLNADFMTWSPSGTIKFWDLNGFSKGSLNVELQQNLGENEAPNECLIVRVSKGAEYLVYGDRYGIIRLVKFLSQELLFEMRAHFSDINDIDLCETSTYTLLATCGRDRTVQLFQCISKSWHLVQTLDEHSASVTGIIIAKDCEFLISSSTDRTVHIRQITRRKDGNTEDFVVLPLKIITLKASPVSITLFSVDSVCNIIVSLLDRTISTYEIPTGRLVGSFKTSDNDFNEAGALDSLATGVPYLNSGKSTILVGASCIEKAVRVYDGKTGALIDKEWGHSTNITDLALHERLDCDEITVISTGFDGIIMMWSLSPKQPISTDCGTTGSCIDISSTAKETPPSSRMPLRRVMSKAELSEIQKKSHNSLPARAVSPPKLIKRKSSRYGSLSQVPSQVPMTTLPTKPLSSLSEKISKTRHRYRTRSRSPFPSPKSSSTRRSSLISIDSKGGKSNSTDIKEYGSLNIATEQVCRTLRAYRRKLLSSDSIDDSSLKELVMELRLTTVALGEKYQKSHIMSETMLTGLLDQYSERLISLFDEKLQLSRLASNNQTQEEPRVLNITETSVSPGSTDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB98</accession>
    <name>A0A0B1PB98_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001145">
        <property type="protein sequence ID" value="KHJ33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB98"/>
    <dbReference type="STRING" id="52586.A0A0B1PB98"/>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OMA" id="TMVNPQN"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059029" evidence="1">
        <location>
            <begin position="18"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="277"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="816" mass="90626" checksum="9FFDF04104FA0C8F" modified="2015-03-04" version="1">MRQTQLVLTCLVASVFAQTFDILSYVDQLIGSSNGGNIFPGATLPYGMAKAVADTNSPSNQGGFTLDNSNITGFSSLHDSGTGGAPSLGNFALFPHTGCKEDDVQECVYSKKARATPFLNSSVKASPGYFALDLVSGIEAEMTTAHHTSLFRFKFPSSSSNESPLILMDLTDLSDSRQNNGTISVDTNTGRMTGSARFLPSFGVGNYIAYFCADFTGSTMRDNGIFVDGRASADVKDLTISRSINGYPIPGGAFIRFLPRTESVLARVGVSFVSSQQACSSAEREIPDFDFTKTKTKAEDIWRTKMSPITVDSTGVDSSYLKNFYSGIYRTMVNPQDLTGENPLWQSDEPYFDSFYCIWDLFRSQLPFLIIVDPEVVAKQIRSLIDTYRYEGYLPDCRMSLCKGLTQGGSNADVVLADAYIKNIVQDIDWETGYEAVIKDAEVEPFDWCCEGRGGLDSWKKLGYIPVQDFDYKGFGTITRSISRTLEYSYNDFTIAVLGNAIGGKTTDVEKYIERSGNWKNIFKEDQESIWYKFDKLTNQTNITDTGFIGFFQPRNLNGTYSFQDPLKCSNVDTNSSVCSLQNNAVETYESSIWEYSFYVPHDQATLISKFGGPDSFAKRLDYLHDNNITYIGNEPSFLTVFQYHYAGRPALSAIRSHFYIPAFFQITPDGLPGNDDSGAMGSFVAFSMMGLFPNPGQDVYLITPPFFQSVSITSPLTGKTATIKNINFDPTYKNIYIQSATLNGEIYTKNWIDHSFFTEGKELILTLGREESSWGTDVKDLPPSLGEYQGFQKHIVNSKSFNTSQNNPLLYKMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBC1</accession>
    <name>A0A0B1PBC1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000353">
        <property type="protein sequence ID" value="KHJ35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBC1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBC1"/>
    <dbReference type="HOGENOM" id="CLU_016357_0_0_1"/>
    <dbReference type="OMA" id="YRMYIEE"/>
    <dbReference type="OrthoDB" id="4115389at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057940">
        <property type="entry name" value="Tri-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24465">
        <property type="entry name" value="Tri-helical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Tri-helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="537" mass="62586" checksum="FE458175737C1C16" modified="2015-03-04" version="1">MVYDWGNKEEMCYRMYIEEKRSLEDIMEYMKENHKFNPSKRAFQTQFKKWDFPSKQHPAYKNPALVKRVKELWDCNASQREMLQILNGEGFVIKERELMRVRAKNRWLLRVPNNVKNKKQLPQQEVLSQLQNALFSEESLIGSEIDSKTLKKVSTQSLLDVTERPVSPPLSPEVLKKRQERLLKLQNESAERWASRKRRRRTRGWAGIPADPPGPPRFPSETTIDESKAALNLNHQLYRDIRSRFQKICEDAAIIKKTVAGPERWEAAKHRLIQDSQHLQSVFWLNNENQDAKKLALDVVCSDVTKRMRTLERRMTIAEAKNALGVNPEQSRQLRDAFYKVLKADHFTSKLEAGEEHWKKLKNQWIQGSELLLKILAPGETDPRHQNKIKAVEVICRDVMKRLRDDQTKRDPLRRRINNCNSISKPLEQCDESTSSKLNSSLGTSLFKLPSQAQTNQSHLANNLNISSHQLRNNSLENLLEIKLTSVPLQMMPRNEILVDHNNNIQIDPSLLIATTNNSLLHNQNFKDHFDAPQYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN9</accession>
    <name>A0A0B1PBN9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative developmental regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g3170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000931">
        <property type="protein sequence ID" value="KHJ34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN9"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN9"/>
    <dbReference type="HOGENOM" id="CLU_034766_1_0_1"/>
    <dbReference type="OMA" id="KPNSYMD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="482" mass="53690" checksum="67DE70F41CD228A2" modified="2015-03-04" version="1">MASAQSRQQYAGAMASQVSGLSSENCEIIIRQEPNCARVSLGKDKERKPVDPPPIIQLKVNPNIDPKQTFLQSPYIFMSCSLIGPNDHNQPPGTLGASLTGTVVSSLHRLKDTDNQDGGFFVWGDLSVKIEGHFRFRFILFEIFEDHVWYIKDIVSSPFPIFSSKNFPGNPETTFLTRSFGDQGIKVRVRKEHRTLMRKRGLAHDDFESQHYGPRKTNSSQARSKQTSRDIQETIRPIECQSDSVDTCYDTRSQFERNYSSQSPPSYGCSIPYEESSKRSRNSSESAQIPTYGQSLGYTTRQYVDTQSNAFLSYNSQSQQAGAFSYTCEPSPIFSQSTAPRQQFFTHQIDTGEPPPPYDLHAQRSPTSTFFPSHQHTAYSNTAIPHLSRIDSTQSTYDTLGISSRGQSSPTGISSMSDMAPFYTRLNSGVSYSNVSLSSSDRRDAYQTYPVQASFSNDPNGFLARHPGVTTIDGSTALEGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBS8</accession>
    <name>A0A0B1PBS8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000294">
        <property type="protein sequence ID" value="KHJ35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBS8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBS8"/>
    <dbReference type="HOGENOM" id="CLU_020227_0_0_1"/>
    <dbReference type="OMA" id="LIRECKM"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="45368" checksum="C606D4DCB3B6D938" modified="2015-03-04" version="1">MDALEAELSKLKKNMTLSKSIRDVDSLIEQLETARETIAMDPNSASITLATLQNPLKKGFEQVNENLNQVHKTYAKYGRSLDKHVPIKALPENLDAIASHTKLINRAIAMHFIREGQFSLARTFLSEGETTKMTVNDQLMSDPEELKAEDILQAFLKMYSILEDLKVYNLESAIQWARQNSLQLEQHGSNIEFELCKLQYLWLYHGPEKNGLPDDKNNGLMGAYNYARANFPRYKARFPREIEQLVTALLYRSNLKQSPYYRLLNSESAWENIYSSFVTDFCSLLGLSSASPLHIACTAGAIALPTLLKFADIVRDKKTEWTTQSELPVEIPLPRGMFFHAIFVCPVSKEQTTEKNPAMVMPCGHVLAKESLQRISKTGRCKCPYCPSESLMYDAKEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT5</accession>
    <name>A0A0B1PBT5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000123">
        <property type="protein sequence ID" value="KHJ36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT5"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT5"/>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="338" mass="39379" checksum="2C037F4E70F62DCB" modified="2015-03-04" version="1">MPSTHKKEKPWDTDDVDKWKIEQFKPEDNAGGTFAEESSFVTLFPKYREVYLRGVWPLITRTLEKYGIGCQLDLVEGSMMVKTTRKTYDPAAILNARDLIKLLARSVPAPQAVKILEDGVACDIIKIRNLVRNKERFVKRRQRILGPNGTTLKALELLTECYLLVQGNTVAAMGPYKGLKEVRRIVEDCMANIHPIYHVKELMIKRELQKDPELAEENWDRFLPHFKKRNLSKRRVPLKVRDKSKKPYTPFPPPQEKSKIDLQIESGEYFLGKLAKERAVKEKRLEKQQELKAAKLKKREEEFVPAVEDKPKSKKRRKEESTIDEVQKKKKKKKKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBZ6</accession>
    <name>A0A0B1PBZ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001000">
        <property type="protein sequence ID" value="KHJ34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBZ6"/>
    <dbReference type="HOGENOM" id="CLU_1455420_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20711" checksum="942DD5B5B7BD00EB" modified="2015-03-04" version="1">MKSHPVFHASLLEPYATHPLPGQKKLPPPPVVVDGEEEFFVEEFFRCKASWEKTIPRAIDKALSAPQIRDIDIPPISYIQMDDPFSTPVEIPSTSNATKNPHLPSLDLDYPDPEGNFPDCELPYDDPPHQPGKIEEALLSISEAASQRIYKAELLFGSIAKVLDCHGFTVDLSLGGYLSNHVTKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC69</accession>
    <name>A0A0B1PC69_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000087">
        <property type="protein sequence ID" value="KHJ36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC69"/>
    <dbReference type="STRING" id="52586.A0A0B1PC69"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="472" mass="51862" checksum="E8CCB6FD6047A6A9" modified="2015-03-04" version="1">MTDSMDISQESQAPSTERSQQPPPIPPIPPIPPIPPIHNPSPPIASPSSPSQTPPSTTSAVGRQMLKPVAPSKRPKLERPLHNRRDNSEIANAFIPKELAEIIATRQQKEEAVALKAYLRQAVVNFAAADLSPSPPCVLLHTRPGNKNEKGKEKEKNLPMKVAVAIPKTIPKQVINQGSMKKVEQQKFAPNSINTWATVAWKSQKKAWVVNVQVLKADTRIRGTQKPSNNEKPASIVSDKRLFVRLPIEHEWRKLSPVGICEVVVKKLMISPTLIGKIKPVHSGFVLSPCSTEARETILNAGNGLFLSGAKFEEASNWISVIDPTVPLTIRTEQGEIEVSKSMLTDEIEQVSSIRPAHVKFYGANKAEAPHRTWIAYFTKAPSTAFRVFDESGVARRFKKQQPLDFCKWCNGHHPTKNCSRAPSCGNCGSTNHTEDLCMALSSAEIVGVQTAQTVIDVLLAQLARVYLLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC75</accession>
    <name>A0A0B1PC75_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methylglutaconyl-hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC75"/>
    <dbReference type="STRING" id="52586.A0A0B1PC75"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OMA" id="YEQAHAW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="31627" checksum="007186C2D322AEC8" modified="2015-03-04" version="1">MIHDLRAPTSGKVRVLSLNRPAKRNAISRQLLKELRQAINQIHTEYDDYEKKLLENKRNIKNLNQPSTRVLILTSSVETCFCAGADLTERESFTAEETASFLAELRGTFSSLSSLPIPSISAISSVALGGGLELALCSHLRVVTTTAILGFPETRLGIIPGAGGTYRLPALIGHSRARDLILTGRKISGQEAHFLGLADRLVEILPREDESNTDLRKRALEEVQETSINLAFEICEGGPLAIRSALKAINSGNPDIENQMYEKVVCSDDRNEALVAYKEKRKPIFSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC81</accession>
    <name>A0A0B1PC81_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g6517</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000232">
        <property type="protein sequence ID" value="KHJ35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC81"/>
    <dbReference type="STRING" id="52586.A0A0B1PC81"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="OMA" id="KMHACET"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="946"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1092" mass="119262" checksum="F7CED645A7E4B98C" modified="2015-03-04" version="1">MPWPQFRRAEIGSKQLRENSHQLENLEQLFTNGTEVNGGSSEITSSGRRITHTRSLSTIAKTTAERYALLTPSATAEQLKTSLVSGLTAAEALSRFHYYGANELPNEAPEPIWLRFLKQFKEPLILLLLCSAGASLVVGNKDDAISIAVAVTIVISVGFIQEYRSEKSIEALNHLVPNHAHLIRGDQIGTTNSQNTSVWPPTSSKEHTGEVSKDFSIGTIDLTNIEIKSSKVMASQLVPGDLVLFSTGDRIPADIRVTKAVDLTIDESNLTGENEPMNITSEAKDYCGPTTISHLGALESQRFQSDGENGIGLGAETHSSNLTNIAFMGTLVRSGYGQGIVYATGENTHFGSIAAAVTKTESPRTPLQLSMDSLGSHLSQASFLIIAIISMIGWFQGKGLLEVFTVSISLAVAAIPEGLPIIVTVTLALGVHRMAKQNAIVRKMPSVETLGSVNVVCSDKTGTLTMNHMSTTKLWYFGIDEPLKVDSGDEAIEATPDPITLRILRIGNIANNARLTWQYSSPPSASSAAILSSTARQSRGENFLRSRWVGQPTDVAMLDLLDRFREHDAREGIEHRVGEMPFSSERKWMGVTVGDLTSDWASSDKEIAYVKGAIDRVLSRCDTYVNKDGQEIVLDTKHRQEALDMAENLAKEGLRVIGFASGPVTRYTKPVNHKNSQIVPTPKVIPLTNNVSHREDVYKGLVFAGMVGMSDPPRSGVRKAIRRLERSGVKVIMITGDAEATALAIGKKIGMSIPSSRSQSLESLTASSVLSGNRIDEMTDKELRSAMVNVSIFARTSPDQKMRIVSALQERGDIVAMTGDGVNDAPALKKADIGISMGIQGTDVAKEASDMILTDDDFSTILRAIEEGKGIFNNIQNFLTFQLSTSAAALSLVLFCTSLGFKNPLNAMQILWINIIMDGPPAQSLGVEPVDPDVMLRPPRKRNAPVLTWSLITRVLSSAFIIMMGTMAVYTHEMLTDGQITKRDTTMTFTCFVLFDMFNALNCRSEMKSVLRGEVGVFSNTLFNWAVSLSLGGQVLVIYLPWLQEIFQTEALGLLDLVSLILLTSSVFWFDEGRKWWKSRYRRKVSGYSQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM2</accession>
    <name>A0A0B1PCM2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nefa-interacting nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000750">
        <property type="protein sequence ID" value="KHJ34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCM2"/>
    <dbReference type="HOGENOM" id="CLU_067596_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="24944" checksum="B8047F71DB053C2B" modified="2015-03-04" version="1">MEITAKTTQKSEEAWTKAKKEIEDAAARKAEEANRKIHKADKSLYEMLEANKAAKQEAFEEATRLRNQFRTLDEDEVDFLDSVLECTRAHEAKVHAETVQGLQSFRRRQAEEDQKVLSEVDTLLSVNNDVGDGGGEKSSWVVSSSGCRKRKRARVSKIGLVTRKISDNSSVIDKEILANNPNNASKEITKFDTLPKIHSKSEGPLLPPIVASKSALVNYGSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM5</accession>
    <name>A0A0B1PCM5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000894">
        <property type="protein sequence ID" value="KHJ34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCM5"/>
    <dbReference type="HOGENOM" id="CLU_001613_7_1_1"/>
    <dbReference type="OMA" id="SSAWESC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="11">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="434" mass="48290" checksum="B6760EA0837F09E5" modified="2015-03-04" version="1">MDKSQLEAYNACVYGDKSVFCTGGAGCGKSFVLSNVVKRLRAKYNTYPGAVVVTASTGSAAFLIHGITLHRFAGVGIEENNLELMIGKAKSKINARNWRRVKILIIDEISMISSTLLDNLSLVAQRIRANNEPFGGIRLLLFGDFLQLPPISFLGFRGHISRAFESTVWADLNMKVIDLKGHNRYGNNFVLADVLSRLRKGSHNVEDTNYIKNLVRTVTYEDSIEPVRLYARKDKVSRYNSYRLSQLKTECVVLESTDIGTESLLSQCPVEKNLQLKIGAQVMLVRNINNVLVNGSVGTLVEFEKGEKGNMIPIVNIVTRNSRIIRYKADPVEWSAENALGNVAAIRNQVPLILAWAITIHKSQGRTIPRVIVDMEGVFEEGQCYVALSRCPDDSKMQVLNFKESYIMTNAKCVEFYASMSDNNPATGVATYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCU2</accession>
    <name>A0A0B1PCU2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chaperone protein dnak</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000493">
        <property type="protein sequence ID" value="KHJ35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCU2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCU2"/>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="OMA" id="DQVLMDH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="563" mass="61626" checksum="0D8C794982578F57" modified="2015-03-04" version="1">MISDVELSRGLEDRTVIGISFGNSNSSIAYTNSEGKAEVIANEDGDRQIPSILSYVDGEEYYGQQAKQQLIRNSSNTVAYFRDFLGLDYKNIDPTHCQASAYPQEHESITTFRIRETDSDEESIISISEIITRQIRRLVKSATDYIGKPVDAAVITVPTNFNDQQRDCLVECAKNAGLMVLQLIHEPVAALLAYDSQPDAKLTDKNVLVADFGGTRSDISVVASRGGIYTILTSINDKNFAGVNLDQALINHFASEFVKRNGKDLVPLDDPRSKAKLKLESEATKKALSIGNNASFSVESLLSGIDFSTTINRYRYETIARKVFEGFNQLIITAIANSGLDILDIDEVILSGGISHTPRIALNLQKIFTSSKIQILAPSTLPTAINPSELQVRGAAIQANLLKNYNLEEIKLYMNPSLSTSTYLSKAVGVLSISDDCNKGVFIPIIMEKTSVPARRSILITTPREGGDVLIKIVEGESCVKVSRPEPQKKSDKGKDTSDSELDSDSEQDDEEEEIREKVWQVGNVLAEAAVRGVKKGSKVEITVIISADLSLSLSCREENVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDB3</accession>
    <name>A0A0B1PDB3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000614">
        <property type="protein sequence ID" value="KHJ34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDB3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDB3"/>
    <dbReference type="HOGENOM" id="CLU_001575_0_0_1"/>
    <dbReference type="OMA" id="PNANYMG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="3">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119488" checksum="00F0EE2941AE4109" modified="2015-03-04" version="1">MNPAIPSALSSQAFASDSRPTDFSCKPWESSSFKLSDKLQEDSQVIPRAESNSSAIPEQKEFGVGTHQETMSRLRGLSRHRTSSSSNGGSQNNIRPSKHPSQKAMLSKALQKANTAVLLDNAQNFEVAKHSYSEACALLERVMSRSSGDDDRRKLEAIRNTYTSRISEIEKISSHHSSQGKALPERPDFGLRKMNESNLIGPENDEEDGDEEEEVTSSAYASLLSDDPKCSTTLQSRSTFSSQLPPRRESLHKQSLDTFMHKPGLHRGRSQRKLSKDFNNDRDSQGENQFISAKYSPHRSPSPQKTAEFNIHTNYSQLEDSGSDLNNFSYLNSHSRMLSCDSLSWLDTIDESGRSTSPSLHSRTSSMKFPRKIPRCTNVGADAEFDAALDAAVEAAYDESFMLTDDFRDNDFTANLGQEVQLKPKNLLLSDDDVTEQLNHDMERANIAQQQQCDFVNDNDLDYYEEDEQMLEEITKDYIMDDFEFGLQSKSTLPRESDSSGFSGRTWASSIVSNPTTASTITSTTSRACTSSQAPFLTLNIPKDGSYSPPLIPPPQQTLPSPPSPEQHVNQQLLHQPASLVTKNGRFSDIPEISLNTNQSRSSNFATSVPSFLEEKNYVRPEKPNSSSHRPKMLRLPSKNSSFADVNSSDFLPALSSIPLQSMNSDFDVNNHQSTLSAPLITKSSLRKNFSSSSLKNLRKRNVTMSSHEGGGSDLSPGTPMNTQYHGRIDGSRIQPAIPNLPTPISMSFRDKQSAKQPGNIYLLKIDIPNPESPQLISSPDGRSPISLEPCPNEYLLRPFWLMRALYHTITHPKGGYLSNKLFVPCDAWRVKGVKLKNIEDKISNCDLITVALLKISLIDTLNVDEMLDEMQKLEDILEQAQNSLSKKLGNEVGPPHGNYGGHKETGIDGDGENHSGIRKSGSNSVKSSFSWRRLRSKNSALGLSQNYSNKQNIEGKKDDFKMASIPMTLNSTMKIYFSRRDLSQINFTGPNANYMYSLARLFDASQIIDQIARQIELHGHRRTDKTLAGLELSIRHAAEFFSYYICRFVLNDIGLMLDKFVKKGGEWVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDV6</accession>
    <name>A0A0B1PDV6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative bromodomain associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000025">
        <property type="protein sequence ID" value="KHJ36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDV6"/>
    <dbReference type="STRING" id="52586.A0A0B1PDV6"/>
    <dbReference type="HOGENOM" id="CLU_064111_0_0_1"/>
    <dbReference type="OMA" id="EWEEDWQ"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="5">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20634" checksum="0AE9B51D01BCAF58" modified="2015-03-04" version="1">MNNPQEVHHSLLRPCVLQILRATGYHSTRPSVLDTITDLTARYLTLLAQSTVTHASLNHSDPELALEVSIQDVRMAMQDCGALGPEIMLEEQEFSNLEDTRGVDEFIAWAMGPKAQEIRRIALDGSDEAKEDYLTVLKKKQSTTGDEESRYVGTVLGRDAEPRTVKIEGSEITNLKEWREAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDZ7</accession>
    <name>A0A0B1PDZ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g3245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDZ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDZ7"/>
    <dbReference type="HOGENOM" id="CLU_006909_8_2_1"/>
    <dbReference type="OMA" id="CTHFNLW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="466" mass="52754" checksum="9A6237BD8BCD83A6" modified="2015-03-04" version="1">MVSSKQLTTFSDYRYPIGTPDFLSTEEYCRYLEKYCKHFRLNPFIQLESRVLRVQRDDTRGPGHIVHILHAGEVSQWPCDAIAICSGLHVIPNIPEIPGLSNIPQNFHSSEFKNSRQFGEGKNILILGSGETGMDIAYLAIKSRTKSVTLSHRDGFFCAPKRAPETNFFGIAPCPIPRGNVPYDVGAASLFDTSYVHPILRNSFIPWEYYDLFAKFTTWLVSGTKAGLDQWIGEISPERFHVSKIFFNKSTRAIPYISAQYRKPSVLNSLRSFIATVPIPTSTQGRQIDLAPWPKKIDKSGVVEFMENGRPEAKSFKNKNLKPDIVILATGYKQCFSFLDDDYPCASDANIRNIWREGCETTSPKSRITYGVDHESYAYQLALDIGAAPSFTQVLLLGWKTTVSWALSANVNPKFRLVGPWQWNGAKEIMEGEVWDTITRRRFFFGKQVLAHYSPLLLKFTFQGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEB9</accession>
    <name>A0A0B1PEB9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rna-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000302">
        <property type="protein sequence ID" value="KHJ35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEB9"/>
    <dbReference type="STRING" id="52586.A0A0B1PEB9"/>
    <dbReference type="HOGENOM" id="CLU_047273_2_0_1"/>
    <dbReference type="OMA" id="AFNCHFP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="270" mass="30371" checksum="1E371F7DD96923E6" modified="2015-03-04" version="1">MSSTEYKSKITWQLDSPFTTNNVPKLSPEHLDTIVSLLSRLITPIGQYRRDHITPSKGKRSTKSSRKQKSAKQQKILSQRCQTPLVPEISKYVIIGLHSVVRKLESLSNLSRKQSIRSSDLETLEIDHKTIVDDASPSNCHFLAVFILSSSMPMAIEDLLQQLIVTASLAHPEYPQTRLVRLSENYHNHLSQCLGIPSASMIGILNGAPLSKGLAEFMTNHVPEIRIPWLEGSSSVQYLPVKINEMENLVVSVVKHKKTQIMRKQNIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEH2</accession>
    <name>A0A0B1PEH2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000449">
        <property type="protein sequence ID" value="KHJ35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEH2"/>
    <dbReference type="STRING" id="52586.A0A0B1PEH2"/>
    <dbReference type="HOGENOM" id="CLU_008220_2_1_1"/>
    <dbReference type="OMA" id="SALWENF"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="441" mass="50766" checksum="A9E327FA6E5968CB" modified="2015-03-04" version="1">MNYGIHISCMVEDKLALIQRSSHWSQSDETKAYERCLQEVLEEEGRAWADGNIRLGDYILLVDSDTRVPSDCLLDACSEMEQSPEVGILQFSSGVMQVVNTYFENGITFFTNLIYTAIQYTVSNGDIAPFVGHNAILRWSALQSVSYIDEDNYEKFWSESHVSEDFDMSLRLQCNGYTIRLATWTGRDFQEGVSLTVYDELARWEKYAYGCNELLFHPIRKWIYRGPFTPLFWRFLASNIRLTSKITIIAYIGTYYAIGAAWIMTTANYFIIGWFNGYLDKYYTDSWQVWFSIIIVFNGLGNLALAVMRYRIGEQSLLYALLENIKWTFMLAIFLGGLSLHVSQALLSHFFEVDMTWGATSKEAEFSNFFIEVPRVLKRFKFSMIFSLLGIITMIILACAPFVPYDWRITDFVAILPMATVTTSHLLLPLALNPALMTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEU8</accession>
    <name>A0A0B1PEU8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000384">
        <property type="protein sequence ID" value="KHJ35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEU8"/>
    <dbReference type="HOGENOM" id="CLU_041473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="378" mass="43079" checksum="0213F15EA737637C" modified="2015-03-04" version="1">MSSNRLCTTCLQSQPSSNFLKNVVSNTYFKTCSTCRNRAKARRRNTHHRSPFEPAIMQAEEAEPNINNQVIVVDNILNDQCPGNENLMNENSNLADRNAALYDPPINISENSNFIHCKGCKKNCHPDLFHDPIRNRSFKQCTDCRRRDFNRRHPESLQDQPNSRPQHPRALPFNPPTVAPFNAAIDTAYIHCRMCRLNYPSESFANAASNSLYATCSECRSIQHARRYPTVFEPTPNQVPSNLIEDVDNSNDEEVEQLAANIGMFEIVEEEVFNGPVPEEAPTGDDPIFMISQLQSREFRNHDEIQRRLQADEEAFGISNPDEALQVDDDIIVSEIDPNIDPFLEELPPPEIDNENLLENEILNDPFVEENFHAQNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFH3</accession>
    <name>A0A0B1PFH3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000314">
        <property type="protein sequence ID" value="KHJ35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFH3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFH3"/>
    <dbReference type="HOGENOM" id="CLU_008535_0_0_1"/>
    <dbReference type="OMA" id="HATVCVD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="951" mass="105653" checksum="BB08CC0B9A8D5D8B" modified="2015-03-04" version="1">MQLEHTNRSALNVKAICANEAYSDEFCSDIDSRKSDELAADVHEDHVPGLVHNLRIGNSILALAVGCDQIYAGTQDGELVVWSLSSFEIIHRIKAHTRSILCLHLSTDGKLLVSSAGDAIVNVWSPTSFKLLYHVYSTYDVGDVFSVAYSPQFQMIYLGSQNTSIQWCSLKDTETRSPPNPNNHPDRRNHRFFDSVAAGGTSTPRSPSTRREVGDGALLEINKSHMLQYAHFGYVYCMLVVNRKAPPLESDNDFLISGGGDGTIKIWELSHDQDKGIKEIACLGTDNAESVLSIALDDSYLYSSKLEGVVEIWDLDTQQKVRVTKTHDGHITTLQIGWGFIFSASSTGFARKNSTTRHNELCKSPLSGQKDHSLSYWKAHEGRIMASALKEYKGQRLFITGASDNIVSIWEITGCATKSDIQAKTIIENQLIKSLREFVSFETISSDADHSEDCWNGAAFLRQLFKKNGAVTKMLTANKWNPVVYAKFKGNPNTSMKRKKILFYGHYDVVPAENKQKNWITDPFKMKGVDGYLYGRGVSDNKGPILAALYGAVDLIHEKELESDITFLIEGEEESGSRGFKNIVQKHKDLIGSIDYIIISNSYWINDEIPCLTYGLRGVLHATVMVNSNHGDIHSGVDGSFMMDEPLFDLTAIIAKLKGKHNRVMIPEFYDKILPLTPAEIARFDDITETLTQCNPEIGPRDLLKASLMARWREPSLTIHRYKVSGPDGSLVSSHASAAISLRLVPNQEVEDVTKSLISFLTNAFTELNTHNHLSINIENQADAWLGDPENAIFQTLEEAVIDVWGPIGETGRSSVPGPNSKKSNSNSLNLNNDFKPTPATSSSLSYGSDHNSQAANLSKLKSTQQLSDEPQTNFCDNGYKKRGGKPLYIREGGSIPSIRFLEKEFGAPAAQLPCGQASDSAHLENERLRVVNLYKSREIFRRVFKDLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFN3</accession>
    <name>A0A0B1PFN3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000144">
        <property type="protein sequence ID" value="KHJ36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFN3"/>
    <dbReference type="STRING" id="52586.A0A0B1PFN3"/>
    <dbReference type="HOGENOM" id="CLU_012350_1_1_1"/>
    <dbReference type="OMA" id="ERLRYMD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="649" mass="72095" checksum="D6DF6638597BC8F9" modified="2015-03-04" version="1">MAGPSSHNGVPAEDGSSIISTKGIEAFGRKFTSTAGHLIGDSISGTHYQNAMSDLQKQLRRPNIQRSIFSIATSSPTDIIRSRFSTSEIQYRALTYLPDELLKNIPENENTYSLFQGFQASVPQSISKGKRNQKKTSKNRQLEVDRPESTTPSLIINLEKEKASLSHQFEMMRIRKNMASCEIQEVDNKVSNLLNMRKILLERLAWLENEEALLEHHILDVENRLEDAQELMGDIKAFAPETNSDDELKTLENDAENTTFMSESMYEKLTTSNILPNRSKQKKSITRKSVLITHENLKPGSKIREFRAHRDAITTMDFDAPFGTLVTAALDDTVRIWDMNAGRCIGLLEGHTASVRVLQVEKSIVATGSVDATIRLWDLQNSTHAFYNNHIQKEKNVDEDSFVLENGEIGPTESSLRNASLFTLEAHMDEVTALHFQGDTLISGSADKTLRQWDLEKGRCVQTLDVMWAAAQTTINMGPMQGIWRKSGRTAGSDADFVGAVQVFDAALACGTADGMVRLWDLRSGQVHRSLVGHTGPVTCLRFDDVHLVTGSLDRSVRIWDLRTGAIYDAYAYDAPVTSMMFDKKSIVAAAGEDVVKVYDKIEGRHWDCGTGPDVKEDGKLAAIVERVGIIDGYLTEGRSDGTVGIWAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFS4</accession>
    <name>A0A0B1PFS4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative garp complex subunit vps53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFS4"/>
    <dbReference type="STRING" id="52586.A0A0B1PFS4"/>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="8">
        <location>
            <begin position="609"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="824" mass="93423" checksum="D83120F60AEB13BC" modified="2015-03-04" version="1">MNTEANISNFCFDSVDFDPIEHLNLIFSNPTSLGSIESVHNALQNHQQDLSRSINLLSVQQSRNSNTSIERLQCTKSELDNLFSRIESVRTRALETEQTITHMTADIKRLDGTKRNLTLSMTALKRLQMLTTAYEQLRTFAKSRQYRECSGLLQAVLQLMKHFNSYRSIDQIATLSRNVTDLQREILEQICEDFEICFSKDEIAAKKGILHEACIVMDVLGSAAQARLVTWYVNTQLREYRQVFRGNDEAGSLDNIGRRYSWLKRILSMYEEKHEVIFPKQWRINEVLANEFCEETRDDFNDILEKSMRRTDGSKVDVNLLLSCLQETMDFEHSLEKKFSSDSRTSIDTRNSLDERQTTFERSISKAFEPYLSLWIEAQDNSLASMIQKYRKQPLLPPDEEFTSQAIIASSIELFHFYKTKLAQCAKLSTGERLLDLSKVLAKYLDEYAQQVLLSLLQKQGSPHLSDTILILNTADYWHVNTLQLENNLKKRIDAQFVSKIDLSSQVDIFMGVASAVITTLVQKFEVACEVSWREMRNINWSRMESVGDQSSYVTDFLQNINSQAQEILSLISKPQYARVFCDKLMDHLASLYIGNIVQCRPISEVGAEQMLLDKYVITKSLSNILSHSTHPFSLVAKSSFAKRTQNVFSRIDPILKTLQVRLSPPEGLVQAYLIHIGDSSDTNFRKILELKGVPKSQQLSLVELFGIHREGKLNTNLVQMNPLLTSLMNSGSMGSSGLGIVGGGSVAASVNIGSSAGKAFDPTGLGEKLFGNVRETSEKLASEETRNPMEGNLMSIGKFFKRDPTSFTRFGQNRQSSVDDNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG21</accession>
    <name>A0A0B1PG21_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dfdf domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000251">
        <property type="protein sequence ID" value="KHJ35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PG21"/>
    <dbReference type="HOGENOM" id="CLU_652456_0_0_1"/>
    <dbReference type="OMA" id="CENIMAN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="2">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="421" mass="47603" checksum="E42687B1A3EACC85" modified="2015-03-04" version="1">MGDPEGKDCXDMQSRAYWAFTPAPREGEDFDLASPCENIMANFIGLCMLVTLSSPPGAQIEGTVSRIEPGKSLTLSNVICPSTGKYTQELTLKADDVQQLKEITTEKTLSDRSILQKSVTSMKSKTLTDPAILSFGKRPILNGRESIETHSPRGQNFKLDVINKGPHNNEDPIVSVENFTRNITLAEVSYEDTKNLEQRPLDGNSLSRNSKTDLKSKKRNQKRILRNFEGEEDTDKDSVNYLKSPASKSKGCKQTPPFEPNSSFQPFSNIKRIGRGRRDEEGWVTEDAMDVLELGDFDFEGGLAKFDKNAFFNQLQAEDSIAAKDRLVSFNRVRSDNFGKNLSNTNNVIDEPRPTKIFSKMKEENCIESPKNFDENQNTSYQVVDITRRNTRIETKIINNRQKLDLRPSSRKELANYYDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG40</accession>
    <name>A0A0B1PG40_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000348">
        <property type="protein sequence ID" value="KHJ35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG40"/>
    <dbReference type="STRING" id="52586.A0A0B1PG40"/>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="45440" checksum="46B1E7523A481E37" modified="2015-03-04" version="1">MGIYLRFTRQGFKRLASGFSNDSFSPALLARAQNMALEHDRLTEEISKVFDNKVAKRIGELKRVTEALKQWDAHEKTLVELNSLLTDPTTDAELNKLVADDIIETKSKIQVVLRNLAAALTPVHPFEKFPCLLELRPGAGGSEAAIFATDLLRMYTTYCARVGLNASILKYETADGPESPLTEAIIEVDTAGAYGKLRTEAGVHRVQRVPATESKGRVHTSAVGVLVLPSLPTSSKDNQLLSEADLNDPSSDYYVNPVDVRTDVMRARGAGGQHVNTTDSAVRLTHIPTNTVVAIQDSRSQHANRAKAWQLLRSKIAQARRDAREEEIMKLRRGVIGVAKMGRGDKIRTYNWGQQRVSDHRSGFHSYNLDDVISGGLELDKIIDSVKTWLLENEIEAMLQDEKASIKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG55</accession>
    <name>A0A0B1PG55_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative vps9 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000231">
        <property type="protein sequence ID" value="KHJ35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG55"/>
    <dbReference type="STRING" id="52586.A0A0B1PG55"/>
    <dbReference type="HOGENOM" id="CLU_017705_0_0_1"/>
    <dbReference type="OMA" id="ETAYCLV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="226"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="720" mass="79664" checksum="B193E841AA9D2AF0" modified="2015-03-04" version="1">MISSEILQSDNQRPRSLHLSKSFSRPTSSNFDAIPSLCRTSSLQITGIDSSFGEKQKHESDTFERNHYDEEFKIYSEIPRQLPDDYYKLPIELIGLSDHFIESLSAKVHQSPPTIEKLSGLFQDFYKVAIDEINIHVLSLSARLNRQRFTSPSLSSSITSAQNKFKTNSETENSDQQMLTLEEIAGRREARKILELKRMALEEAIERKVCEATYDRIWRHRCTHDEEQDEKLRSRTAALSLVGIGLRDLGVNLGVENSEDSNTIQKKESEVAEWLSEARKELCAMNNLKYPLGKLQHLKKAHKAIVETLSHFHPSSSADEIMPMLIYTLITSRPEGINIISNLYFIQRFRNENKIDGEAAYCLTNLEAAISYLETVDLASLRADEVLSGPPKTTSRTNTPSPEIFDPLINPLTPSTSVSAIESTCASPSSEITKEEPPSTRDRVEPQYQSHRLSGLFQAPSSLGVASDAVLSSADQGLESLGNSIGDSYKFILGKLKGRIDDVPETKLETSKTLEDLQKLSAHPPEDTTSNSGASSIRNLGTSNRIRADSGSRIDERILSMIGGRKSSRDKSVDSNKRVSFAEENESGKIASTLQSLPSPNPALVESMRNLGNTLNPMNRISGMGMIRAFGRSTPPSSIKIPSTSSTTINDALDSAIANIASSTPDLTKAPPSKDSIRISPPITKFLELQSAGDMKLNEVKELLRDYKRLASAMKDLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGL8</accession>
    <name>A0A0B1PGL8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g6094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000038">
        <property type="protein sequence ID" value="KHJ36395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGL8"/>
    <dbReference type="STRING" id="52586.A0A0B1PGL8"/>
    <dbReference type="HOGENOM" id="CLU_1556411_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="172" mass="19452" checksum="119245F2F6086F31" modified="2015-03-04" version="1">MASIVNSAQDLISRIDGASPENRKSILTDLFNSGKEIQECADKLRLESEERRQEFSNTKAVLTELRNELKIQQTSATDAIQALAVFKFRLSEAEKLISELQSLPSNVSQALPRSEPFQIDEKFLGENRSLYPAFQRQIKIALRQNSDRYVSLQSQISLIYQNLGTGPKSFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV33</accession>
    <name>A0A0B1NV33_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004748">
        <property type="protein sequence ID" value="KHJ30217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV33"/>
    <dbReference type="STRING" id="52586.A0A0B1NV33"/>
    <dbReference type="HOGENOM" id="CLU_1284120_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="215" mass="24376" checksum="9DB08449B754EEA1" modified="2015-03-04" version="1">MNQSTFHALTRSTQILGQNFGKDNTSIVKSYNIFTNSTRYNSNYFYGILIDTGASISAAGLGQYNALKQIQHLDNLDINANDGLTFKFGIGETPSLGVINFNIPMGYTKFHVVNADIPFLLSLRDLDNLGCIFDNQNNCIRGKNPRNGKTIQVPVIRRFDHPFVTWGSSLTMYCTNIFTNEKLLNDQELRQLHRRFGHPSARRLGCLLKRSYCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVD3</accession>
    <name>A0A0B1NVD3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004590">
        <property type="protein sequence ID" value="KHJ30277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVD3"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="27441" checksum="20CAE92AEA7838F3" modified="2015-03-04" version="1">MEFSQEPQAPSTELSQQLPQIPPTPPIPNSSPLFASPSLPSNPEPQSKTIVSRQILKPVAPSKRPVTERPTQKGIEKLDTQNAFLPKELADIIATRQRRERAWHTRLLILACNGYKKARVVVGEKTQAILSTKASQRQSPTSKTVTSGSDKRLFVRLPQENEWRKLPPAELREVLVRKLMISPSLIGRIKPVHSGFALSPCSVEARESILKVGNGLFLTEAKLESATSWAPIIIPTLPLTIRKEQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW10</accession>
    <name>A0A0B1NW10_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003975">
        <property type="protein sequence ID" value="KHJ30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW10"/>
    <dbReference type="HOGENOM" id="CLU_1679257_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="157" mass="17813" checksum="C0524E65807EDD9C" modified="2015-03-04" version="1">MTQRNNMKNAKNEIFEMSNTDASKTMKVDPLENTNSRNTGNASERGSGAEKALPDADDALGKFKKKTLKEDNFALRPFKILLAEAVEVIESLQKAKTNLRNNPKTKRADENIKIDTIRQEIRIFTRIHLNSTTVRLCKLRLEVVPCFVYFKGLVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY29</accession>
    <name>A0A0B1NY29_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative huge dynein-related aaa-type atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003530">
        <property type="protein sequence ID" value="KHJ30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NY29"/>
    <dbReference type="HOGENOM" id="CLU_000330_0_0_1"/>
    <dbReference type="OMA" id="MERCRGY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="2211"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1586"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1636"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1663"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1673"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1694"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1732"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1744"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1763"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1774"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1796"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1836"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1856"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1875"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1921"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2421" mass="277793" checksum="9B3C19EA6C20BFE4" modified="2015-03-04" version="1">MMNRFQRSLIKKQVTYVNEDSTINVSDFLNHCLKSLTVFIQNLCLNYEGQYAALKATIFSMLRFCHETLDLVTSPIFEEEKFQAHLAIGEDSIVKIKEQNFSLAKNFTDALEKYFTSSFKLTTGLSMEIMWKMLRPVPISSHLTYKTLLSMENLAMRFDKLRWKTSNTVPQLGNIVKSFFNAYRLILASKVDGTALVVTLASEMASLEIHSNREKENITPYFKKQFETIRQYQFLSEMLSDLDEIKVDFDSLVLSDYPSLLSLNLAITTPSSKCLQLVDYLWSEDNEISPIMNSLLFHILGKLNNFQDVKLNGLRLLEAELPNLGHNLTILSHVLYQDSLHKLNQVLLNLIQKVINIHDENSVKFWNFLQANLESRNPQKNFDGFPIKSHIRDTFTNHFLSSTCHIKNIQIQKKSILKLSALAWIEFAIGCIKLYVPNRAYDPDKRQRLELERHQKSKETIMQKLDSMRKFEQVFTGQEFNLRCQMLESDLRDLGKAPEILQEIYRPEISEMTQLQGEFTRLLEVVLESKISVTIADDKGNYQSYQLLQSNINQILSRISLKYKSYRDLTRPIVCILRCLQIGLSLAIIENSDSKVPCKKILELERMAPFLVPYDDYMPEEILNSQPMEYLELIATKSHCDDQSIFHSEARTSTLRVIHELYVKWRNKLDSDRLYSQSEGGLYRFRGDIEDEDKIEEEQLIQLFPSYDEESSQEVNKSPVPQVYRDAVALAKVHSKIFFGLVSPVESIKDLMRNVSRFICPSLQDSCDYVSLNMTSALLPGALLLLDDKIKEQNLTENPKFFNFYAHSNLPECRKLVTIIRKIQIRFSELQRVDEIKHMQPIADILFSCSELLQFSHDDPLAKIITKVEKIHASMHEWQFGGWAPKIHTALTLYEEITSTIISWRRLELSTWAKLFDLEISKYEDDARSWWFMAYEIVIAVPLQKSESKEDIKEYAQKLLSELETYFSSAQLGQFSQRLKLLKQLQKHLEMFKIEVPYLSVISVALANFTAFYSRYEKRLVKEIESGRSQLDKLMRDILLMASWKDTNIVALRESAKRSHHKLFKIVRKFRELLSRPVEDIIKQELPDEEITKAFTPEFSSFIRTSVDSTALELCKNFIPNWSNKNKRFTNISYTLGLMVNTAQTPPDAINCSTHVEYFLSTVVNSISELQKATPSILSKETKGIVKNLKSQKRKVFADTLKSLRIMGIQYNLSSDILLKQRSLSVVLTQLENWKDLTNNEAEIYFQRFINHIIKARNLSKQHSPDLTNAEVSRSVGFLEGFLKIIILQHNLLSKTASLLKQFQSNLQAMANLWAQDYEIRNVSKISNHGKVLQWLPYILQVSIEVIEIHSKFAQVEANMVQNTFESWITKFTTLKKQWDNIPHIPPMIISTERLNLEHFINNATNQLAVELAQIKSTHPNLSYIIDPILPWARITEISEGPNSENISITDLDSSMTNLSNSALVAVENYKKEISDLPTSSDDQGWFVKSDSISRNSLKRLHIESISDQIESSFIIISKLNLNEEKISKAASARCAVALPILNQYLSISLESYNRYLNIHRISCKTSYILAKSFCQIATEGFCTPSEQSLDQDESTDKLEGGTGIGDGDGIDDISKDVQEEDLEDLAQEPSSNENNEIENEPDAVDMADRDIEGEMNELENTPDNHDGYSEDEKNEDQIDEESGSVDDLDPSAIDEKMWDGDSESAEKNQQGDEPSGTLDKNEVTASEETENNSKDNKDKDDFEQNQEEEMGNEQGDEVMENEIERHDQKAEECEILDLPDDMALDGEDQNSTLENNDEIENSLDFEDPDIPDVASNNDDNEKVLEEENENDELGDSVKDSSNHDIDPEKDEEDKGETRKEIDNSEKDNIEEEDHLSKEKDDGLLCEHDNFGETNETNFSDEKGAGENNNHNTDEFLEAQSKSKGDNNNLREEPFEEEMECLNQEQSAMSNTLNDTTGRNEDTAGILESFKKFGDVLEKWHRQQIKNSSLPEKKLNDNIGFDIENTDFQHLQDEDAVPDTQALGTASEEQAFALDESMVIESNDNPDQFPCDEAQNENMNQLNSMEIDEYLNSEKHDLDNSLKSQVGAMIKQSRDLGSENKLPDYNEITKEVENELEQLNYIHLDAEDNLRSLKDAQKQWAHYEGLTRDMTLSLTEQLRLILAPTVATRMRGDFRTGKRLNIKRIIPYIASQYKRDKIWMRRSLPSKRSYQVMLAVDDSKSMGESGSGPLAFQTLVMVSKSLSMLEVGEICIVGFGEGVKIAHNFDSSFSSDAGPKTLQHFGFQQNRTDILLLVRESIKIFRSARARAGSHSAADLWQLEFIISDGICESRDHYEIKRLLREAMEEQIMIVFVIVDDVKKKKGGQSVMDLIQAEFVDGKVATTRYLDSFPFQYYIIVSDVRDLPNVLATLLRQWFQEVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NY85</accession>
    <name>A0A0B1NY85_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01003011">
        <property type="protein sequence ID" value="KHJ31302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NY85"/>
    <dbReference type="STRING" id="52586.A0A0B1NY85"/>
    <dbReference type="HOGENOM" id="CLU_015869_2_0_1"/>
    <dbReference type="OMA" id="NENYLVY"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000010">
        <property type="entry name" value="Dihydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="25"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="420" mass="46604" checksum="7B36B185E7578AAD" modified="2015-03-04" version="1">MIELGLSRMGRLLKHTPQLWKGIHVAGTNGKGSVCAYLSAMLNASGVRSGRFTSPFLIDRIDAITINEKVVNNQTFEDAEAKILEINRTHKIQATEFEIITAIAFEVFAREKIDIGVIEVGLGGRLDSTNIMEKKAVTVITKIGLDHQSWLGNSVEEIALEKAGIMRTGVPCVIDRTNNESVRNVIKEHAQKIGTDIVLSSIDSPFFEDLKHDHLDLEPHQQDNLACAYTAFHLGYTSSESPLHRLLPAIKKVEWPGRLQKLDIECITQRKETVLLDGAHNAQSAQVLGDYVNRKVRTTSNNTVTWILAVSEGKDLKQILKPLLQNEDYVGVVKFNPVDRMPWVRATAPNEILSAAYELGIDPLHCHNAESDVLNILQWAATISNRGPIVIAGSLYLVSDVLRIIRTVKLKQKLGFGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYG8</accession>
    <name>A0A0B1NYG8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative te1b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005253">
        <property type="protein sequence ID" value="KHJ30080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYG8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYG8"/>
    <dbReference type="HOGENOM" id="CLU_900779_0_0_1"/>
    <dbReference type="OMA" id="YCESDIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="309" mass="34073" checksum="9A4C9A658776DB7B" modified="2015-03-04" version="1">MQAQEWPNSIHRWTESFLRNRRVQVRFQDGVTDAKELVCGIPQGSPISPLLFLLYMAEPLRRGNTMAQFSYADDIGILGFGRTLLESPAAAQRAGSTSRHSLAQHMRRLNHVQRGASPKALITAVDACVVPVATYRAEVWCPGLLRPKANGYIKPPTSFHCGLIDKVLHMALRAALPVWRTTPNVVLQREGGIPPARILLEGYRLRLAARLNSLDDRHPLRTRASEICAYSDGSSDGPGRSSWGYVLQRGGTTFQKGNAVLYGGEVYDADIFGATIAFGTAISMKRNEEKIFILLDNQAAVLALQGNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYP8</accession>
    <name>A0A0B1NYP8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002824">
        <property type="protein sequence ID" value="KHJ31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYP8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYP8"/>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="OMA" id="KALCIYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="280" mass="31947" checksum="F60E7F54C4D6F6C7" modified="2015-03-04" version="1">MEIQITCHAKEQEINDTSSDSLIDMINTNLTESKDISSKFQLTENCHHYTSLGEVEWDIQKYWYQRYSLFSLYDEGIYLTDDSWFGVTPEPIAKQVAKDLAKFCNSEKKVLIDMFSGAGGNVIAFARMNQEDGQHSWDQIIAIEKDISVLACAYHNATIYNVQKKISWIRGDSFEYLKSHASTINPKQTIIFASPPWGGPSYRNQSVFDLNTMQPYSLNHIYESCKDMDMALYLPRTSDLRQIALLAPKGKKIEVVQYCMMGVSKALVAYIPGVRDDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ20</accession>
    <name>A0A0B1NZ20_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative delta fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004602">
        <property type="protein sequence ID" value="KHJ30270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ20"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ20"/>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="8">
        <location>
            <begin position="129"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="469" mass="52484" checksum="09017E91A4FCA64D" modified="2015-03-04" version="1">MASTGMAVEQARQRKFSDSVPSTANVSQSSSPGRTPSSSSLSSMSSSPESNKQQFGTLLDTKGNKFEVPEYTINDIRNAIPKHCFERSGLRGLGYVARDIASLTLVFIVFNKYVTPENIANTTVRAFLWAIYTFIQGLFGTGLWVLAHECGHQSFSTSKILNDTTGWICHSALLVPYFSWKISHGKHHKATGHMERDMVFVPKTRQIYASRIGKFAHELDELTEEAPISTLFHSIAQQLIGWPLYLFANVTGHNYHENQSEGRGVGKSNGLGRGVNHFSPQSPLFEAKDASLILLSDLGVGLTVTALIMLSKMYGFSNILVWYLIPYLWVNHWLVAITFLQHTDPSLPHYTGSSWNFVRGAAATIDREFGFIGRKIFHEIIETHVLHHYVSTIPFYHAEEATEAIKPVMGKHYRSNTEGGSIGFLRSLWTTARWCQWVEPSEGAVGDGKGIYFFRNHNGLGQKPMKFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZA6</accession>
    <name>A0A0B1NZA6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative telomere length regulation protein elg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003029">
        <property type="protein sequence ID" value="KHJ31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZA6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZA6"/>
    <dbReference type="HOGENOM" id="CLU_003721_0_0_1"/>
    <dbReference type="OMA" id="RNHLVQQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="530"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128239" checksum="065FE18009123545" modified="2015-03-04" version="1">MIRTKPISLSESKSAISSTCPSSENEVLIKGSLIDKLPAKSADIFLQPSGFESSNSSQNNTLDNNDPLRRFPNCKKNEKESMAISADINPRPRKILRVSSLPSIGFSNLHLKKKIAFDSRIIKIKYNNESGPKITKILNPPESCTPTSSQAPPTKIKISVSHVSKSNERAIHPLFLGSINTKSKNLVDASKKNNNSSLIKQAKDNLGNNPEAQNKLNSNSQSLKTSLNVSCLSELSSKIKIEKSLRIFPKIVESAWPRKGMVHVRGIEDTEIFMSLGSNLKLNLQLRPKKLKDKAVEINSSEDILISISKSLSIRSLVEEIHKSNHEESSFIPSCLRLPIKHNESSIGIRNRVQKQILSNINIPSTKTLSTSEDELQVFNNNLHIQEHPALIKASQILPASLSALDCGTCESNMWCEKYAPKKGEEVLQMGPEALILKNWLSSLTIGIAEARSASSSKLQNLKMDPSTKRKRKSLKLEGFIVHSDDEDFTELDEINLSEQTNRYENDTKVKRTVVRGGDWSKARKFGPKIHHTILISGPNGCGKTAAVHAVANELDFEVFEINSSSRRNGKDIIEKIGDMTLNHHVQRVFGTSRSDNKGNEGKYKTAPTTDNKASNQEVFHSFFKSKSRKIRLHNSSQSLDSSPVSLKPKQLSCKDSTKVKEIQNILSREQKQSFILIEEADIIFKEDSQFWSVIENIIAVSRRPIIITCNDETAIPLSRDYFYAILRFKPPPVYIAVDYLLLIAASEGHIIQREAIKALYEERHLDLRASLSELNFWCQFAIGDVNKGLSWYIPRKYSGSKKNNPQTQIRVISEGSYRKGMGWISQDILASNLPRLEKEENVLHQTSNYWNLDLGDWGMSKCLKKWAKKVCELNQNKDKQLDALKMFTDYIDSLSDSDLLSNSLFGSENQLVLDACSPSICDKELKEYPLAYKIIEAKSASSYHDNAQNLSLYIRSRARNLLQESQKLILSPEINVELTSPSENQVIDLIRKKSISSSETLPREKFGEAFGPISHRTAQLNFSTHGNSGYFEASQFNGTQRIISEDLAPYVRGILANDARLQRDREKISNSVNEGGPGGKKRRTTRAAMSALEGRRRSETRPESYFDYRLNENLVEKTGISYWNEALIRLQEQQIKNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZP9</accession>
    <name>A0A0B1NZP9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002873">
        <property type="protein sequence ID" value="KHJ31458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZP9"/>
    <dbReference type="SMR" id="A0A0B1NZP9"/>
    <dbReference type="HOGENOM" id="CLU_1455421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080389" evidence="1">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="188" mass="21452" checksum="0ACE27804A8770F1" modified="2015-03-04" version="1">MHIFNLSIMISLAILLAFVRADLPDEAKPGDAFGPTNYGYKCAEKVYKKYEIYSAAKRLCDVMKKRPLVEYEKTFEVNLYRQPWTELYDYKLFPLPGPPHIMQPILKDGSIYPIDLLPHLRVNKNSNGHWVRIDPGPDRLVINTQCDIIGAFSDYEYNFDTKGGRIEACTLIRSCDDAFGSPSVETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZR6</accession>
    <name>A0A0B1NZR6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative trehalose phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZR6"/>
    <dbReference type="STRING" id="52586.A0A0B1NZR6"/>
    <dbReference type="HOGENOM" id="CLU_002351_2_2_1"/>
    <dbReference type="OMA" id="MFYESAS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="912" mass="104452" checksum="7E89779F6F47F061" modified="2015-03-04" version="1">MTVFVVTLFLPETIHFNLPSHSQHENQKTSPTPKASLEISKSRNSSLSQSSLFTKDEELTPPRSPNFQGNDDYSFFAQKPNFKSQSNLKSLRFSPNDLPFRTWGSRKTLNQPLSRASSPPSANILKHYKPVWAQKSPLEDSIPQVSPDLGRHDSRDRIFVDAEWTVVPADQGNGGLRNAVQAAERAGKVSDKTWVGTLGMPTDAFEGTQQKQEIEDKLAMEYDSITVFCKDSDFSGHYTHYSKQILWPVLHYQIPDTPKSKAYEDHSWVYYVKVNQAFADKIVKNWKRDDVIWIHDYNLLLVPQMIRKQLPNAKIGFFLHVSFPSSEVFRCLAARKELLEGMLGANLIGYQIQEYARHFLQTCSRILCVEATNEGIQLEDRFVDVFSLAIGIDPIALNLSRTDPEVLQWVKIMQERYRGKKLIVARDKLDHVRGVRPKLLAYELFLNKYPEWRENVVMIQVATSTTEQAELDAAVSDIVTRVNSSWANLAHQPLIYLKQDISFAQYLALLSVADALMITSQREGMNLTCHEFVFCQDGKVEGQNKNGCLILSEFTGSSSVFGGNDLSVNPWNYHQCAEAIKTALVMDEEEKKWRWENLYKAVMHHTAEHWYTSFLDRLDKVYDEQNLRQATSVPRLSVNQLGRIYQGSKNRLFILDYEGTLVNWGSIKDTILTNPQRTLDVLNDVLQDERNIVYVMSDRRPEELDQLFKRVPNIGLIAENGCYIKMYDSSNWIEEADPQEMQKWKNSVEGIMQYYNERVPGSWIEDRSCRLIFHYKTCEDQESANRLAGDCVGHINDACEEQHVRAIPIDGAVVVEPSYWSKATAAETVLNKLTSKYFQQSDQNIKIDFLMVIGVNRNDEVIFRWANELHHRNIIENVTTVSLGRRNTEAGYTLTQGVTGVLMVLQKLAMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P012</accession>
    <name>A0A0B1P012_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EV44_g2609</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01004914">
        <property type="protein sequence ID" value="KHJ30164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P012"/>
    <dbReference type="HOGENOM" id="CLU_000192_0_2_1"/>
    <dbReference type="OMA" id="LEMHHQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1602"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1625"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1653"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="1"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="956"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="22">
        <location>
            <begin position="1825"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KHJ30164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1882" mass="209331" checksum="A4A45B8EC8BD13F8" modified="2015-03-04" version="1">MALNQGGGPHSQPSLVALPQHLQSDTHLTAHLASRFHVSLSTAQLSSHALICLNTYTSSAKGPNGGKEGSAMWGVEDLADRAYARLGARSENQAIVFLGESGAGKTTVRSHLLSAFLNKYSTPLSTKLSLAAYIFDTLTTTKTATTPTASKAGLFFELQYDTASTVNPILIGGKILDHRLERSRVASVPIGERNFHVLYYLLAGTSVAEKTHLGLDSPGTLSNAVHSPSQAVHGDITGNQKRWRYLGHPTQLKVGINDAEGFQLFKTALRKLEFPRSEIAEICQVLASILHLGQLEFEITAGNMALGDEGGYSHEASQSTTAVKNKDVLSIVAAFLGVSAQDLQTTLGYKTKILQRERVTVMLDPKGARSNANELARTLYSLLVAYVIESINQRICATEDTVANTIAIIDFPGFAQQSSTDSVLDQLLSNAATESLYNFTLQTFFEAKAEMLENEEVSVAATSYFDNSDAVKGLLKPSNGLLSILDDQAKRNKTDMQLLECLRKRFEGKNPAISVSSATAKLPGSNFATHNLAASFSVKHFAGEVDYLIAGLIEENEESVSGDLMNLIASTKNDFVSQLFGQEALRTVVHPQEKKTIMQAQVSSKPLRKPSVMRRKGDGVSGISGRDIKDPFDSIDELPESRDGVKGRRGRNIDHGAAGQFLSGLDDVIKSLTAPNTNPYFVFCLKPNDRRIANQFDSKCVRTQIQTFGIAEISQRLRNADFSIFLPFAEFLGLAEAESILVGSEREKAETVVDERRWPANEARIGSTGVFLSERCWAEIARLGERGFTMGRYPIPSDDGEDGVSPGTVHITSKERLLGGPSASPGGILYGIDKKSGYFNNEVDTRSEAGISALGQGDMFRNLDTRQQMAEKGNEKTMVEVEEVKTSASRKRWVSLVYILTWFIPDFMVRWLGRMPRKDVRMAWREKFAINMLIWLSCLFAAFVVVVFPMLICPKQHVFSASELSSFDGKKGRHAYVAIRGQVFDLTEFAPSHFPNIIPQKSILAYAGLDATSLFPVQVSALCQGVNGTIDPSIQLDYTSTNTSGSASVISSTDSNYRYHDFRAFTNDSRPDWFFEQMMLLRANYHKGNIGYTPNYVRKLAEKQVSMAILNDRIYDLTKYLQGGRAVKVKPGEDVPTDVNTNFMSLPVVDLFQQKAGQDVTKFWATLPIDEEMRHRMLLCLDNLFYVGNVDTRNSAQCKFAEYLLLIISILLCSVIGFKFFAALQFGGKNIPENLDKFVICQVPAYTEDEDSLRRAIDSAARMRYDDKRKLLVVICDGMIIGQGNDRPTPRIVLDILGVSDSIDPEPLSFESLGEGMKQHNMGKVYSGLYEVQGHIVPFLVIVKVGKPSEVSRPGNRGKRDSQMVLMRFLNRVHYNAPMSPLELEMYHQIRNIIGVNPTFYEYMLQIDADTVVGADSASRMVSAFLDDTRLIGVCGETALSNAKSSFITMIQVYEYYISHNLSKAFESLFGSVTCLPGCFTMYRIRAVDSGKPLFVSREVVEQYANIRVDTLHMKNLLHLGEDRYLTTLLMKHHPKYKTKYIRTAHAWTIAPDSWQVFLSQRRRWINSTVHNLIELIPLSQLCGFCCFSMRFIVFLDLLSTLVQPVTLAYIVYLIFLIVWDNKSLIPTTAFILLGAIYGLQAVIFILHRKWEMIGWMILYILAIPVFSFGLPLYSFWHMDDFSWGNTRVVTGEKGKKIVITDEGKFDPNSIPHKKWEEYQTELWEAQTGKDDHSEVSGYSYGTKYPGAVSEYNYTPSRPMSRVEGAIGSNLPYDTKNLNLHSSGLSLSHSEGFGLGALGDQRQSQYGGSQFFGQQELEMSNLTGLPNDDAILAVIRDILKTADLMTVTKKSIKLELERRFGVALDARRAYINSGMLRIIFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0F5</accession>
    <name>A0A0B1P0F5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004368">
        <property type="protein sequence ID" value="KHJ30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0F5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0F5"/>
    <dbReference type="HOGENOM" id="CLU_083690_1_0_1"/>
    <dbReference type="OMA" id="RRDIMWD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="202" mass="22868" checksum="0CCB8E9798E5CF11" modified="2015-03-04" version="1">MAEQSFGFPQLILIFLLGGITIHYFFFSSGISSSTNRDSNSASDLRAREADVERIQQMFPQAQRRSIMWDLQRNGGNVAATIERVLSGRGLEEPPQSFQPSLPVSSSQSTSESTSHPTVLPLRPDLITRYDLKAKILEEKQCHEESHLVQETLDNQKKTCQTWSTSKSERQALLKRRRDEMILAARRKMEAKIAAEATQTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0R4</accession>
    <name>A0A0B1P0R4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004294">
        <property type="protein sequence ID" value="KHJ30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0R4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0R4"/>
    <dbReference type="HOGENOM" id="CLU_573897_0_0_1"/>
    <dbReference type="OMA" id="NIESAQT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058806" evidence="2">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="476" mass="48505" checksum="2B327A036D6BF0F8" modified="2015-03-04" version="1">MFTKNAFFLLAVALTEARFSQEQGNGAVQAINSLGDVGNPGEAATLAGGSIQFLLAAANPCKKLEHGDSIVEKLGTDARVIAAARGYVAAEQNFNPFTASVPSICAEPGLPKTESLRGVVPLIDPNVVGQDVENANSKASLDKPFDASGKSVAEVMAANGFTNFTGVKLDGTKVDFAGGQAKGASAASAAGGGAGGGAGGGNKDNKNTAGETNSSDNKKAVENITLMSSGVVRKEGEKGEAKGAGSDEKNGKATAKGASADEEKEEKDGKATAKGAGSDEEEDEKKGKANAKGAGSNQAKEEEEDEENAKGAGSDEEEDEKKGKANAKGAGSNQAKEEEEDEENAKGAGSDEEEDEKKGRANAKGAGSNQAKEEEEDEENAKGAGSDEEEGEKDGKVKAKEVDSEQEKAADDGKSKKKIKACTALLSSIDENNAEAEKKTGENTEQKSAGASQKQAGADAKKESTGATKAKAEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0V1</accession>
    <name>A0A0B1P0V1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PinX1-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0V1"/>
    <dbReference type="STRING" id="52586.A0A0B1P0V1"/>
    <dbReference type="HOGENOM" id="CLU_1373121_0_0_1"/>
    <dbReference type="OMA" id="WTNDVQS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="199" mass="22046" checksum="432D24C82637A28B" modified="2015-03-04" version="1">MGLAAPKKKTKLSYDPNNTRWTNDVQSFGHKMLTSQGWKKGELLGAKNAAHAEFHTSANSSHIRVTFKDDNLGLGAKIGTGVGHGECTGLDAFNDLLSRLNGKTKTQIIQKQQARADIRREIYTDKRLGSINFVSGGFLVGDKIQNLMDSDASRKKKLADRDFVLSQSSDKPELRSTVDENIASKKSKKSKKRKRDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P147</accession>
    <name>A0A0B1P147_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002162">
        <property type="protein sequence ID" value="KHJ32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P147"/>
    <dbReference type="STRING" id="52586.A0A0B1P147"/>
    <dbReference type="HOGENOM" id="CLU_020417_0_0_1"/>
    <dbReference type="OMA" id="GVMMKRV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="566" mass="64023" checksum="5C09348ACF31FF8B" modified="2015-03-04" version="1">MAVVLNSEENSYFSSGPLRRSHSQPKFVNTSLYSKSLCRSLSSNGFPRLPESYSSQSLRDTTSCTSSCDLSDESVSFPSYHEVYYQHSEQYSPPLSSPCEDSYIVSPSLPPTTNNTLTNVSRPQSPDVVERAEDDTAIKIPPSRHVDYLSHNWSEEDIWSSWKHVVSRRKSYSNAPRLENASWRSWVKAKYKLKTVSPETLNWLKDCDVTWLYGPLQTSTEPLCNAPYTSPASCNRLSKNNSFLNKKPILKKRSMSELMLQQSLSTSSLLKQAAAAVQAQQSDTYFECSRNENIVSSTCLHVLSTCSSDLNHGNLSPTSSSDLPSIYGDKKRIHFNEQVAQCIAVDVKGDDDDDELMIPDYADSDSDDGIMMKPSTTKRKYPQLRHRAKVRPNLNQENNKIIEMLPSTTLKYQSDIPASSFDMEEDECDDELWDEDSTILTLSNSQETLKPSKPPMKIFIGEDDEEDNEDDLDWQPLTDYPYRKDSVVVALERMKNPGSSILSHDSLGDNDVDNQVELRRRSSGIFMPREEDEENITSEGLFGKVVDTVNTAKDIAHVIWNVGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P166</accession>
    <name>A0A0B1P166_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003971">
        <property type="protein sequence ID" value="KHJ30569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P166"/>
    <dbReference type="STRING" id="52586.A0A0B1P166"/>
    <dbReference type="HOGENOM" id="CLU_1273090_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="217" mass="24129" checksum="44C68A4B682335B5" modified="2015-03-04" version="1">MAIRENIVASARYVYPIIAPPTAPQIEQDKKAIDESFEKVFSLLDQLAKDTEDLKLSEQNRTSKLDVALNEVESTLSNLKSSSRRREEESRRITDEVHGLRNLIPKAMEEQKETTESQLKELNAELKSLKLLLGQRINSTVSANSSPLGRSLAPTATSPTPQAPTETSLTEAEDKSSEPSSEVQVFLTNTRFNSSKLVIFTFTRCRCKRPVCSACLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P168</accession>
    <name>A0A0B1P168_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyl-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002140">
        <property type="protein sequence ID" value="KHJ32357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P168"/>
    <dbReference type="STRING" id="52586.A0A0B1P168"/>
    <dbReference type="HOGENOM" id="CLU_027519_0_0_1"/>
    <dbReference type="OMA" id="KMANDNS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="176"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="492" mass="55318" checksum="2738E0BE2B6AA7DC" modified="2015-03-04" version="1">MSKFEELGPSPSPSPSLMKLSAPIIKQAPVVVNRVMKTGFQRMLGHSNQKAYWDISTELTIKALDVIVNETKPESLHTIQSLTLKDFGVTGKIWVSKAILPPPPEDSIRQVLFKAIENLKWPGDAPGGYDHPEIAHVEGEWTGYRSNANLLSRELKISEREKYEAMMQEVTSTATIMYIHGGAHFLLDPAFYRTMTQKLAKNTGGRCFSVRYRLAPQNPFPAPLLDVFLAYVSLLYPPPGSFHAPVPSSEIVFAGDSAGGNLSYALLQLILELQRSSLKIIWYGEERVVPVPGGMACLSPWLDITLSMPSNVTNRQFDFLPKRELQFKSSGVWPSNPPRKFMYANDTLVSHPLVSPVTVTDWRGSCPIYVAVGWELLADENKFTIMQMANQGVTIVYEEYEAMPHCFGLLLPKAASFGKFHQSWAQNIKKIVNRPYEMKTSGTLIRARSLKCEELNIYNLSPLTHREIIKFIEDKARDEPIKRTSSDIKNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1A8</accession>
    <name>A0A0B1P1A8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative camp-independent regulatory protein pac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002400">
        <property type="protein sequence ID" value="KHJ32018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1A8"/>
    <dbReference type="HOGENOM" id="CLU_027883_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="449" mass="51181" checksum="6A145E2DC50D6D49" modified="2015-03-04" version="1">METYFGHIKTPADAIKLFEACRLGLLQRVRRRLSEKQRQLIKSGSVFIWDEHEAGMRRWTDGKNWSPSRVSGSFLTYREMDGKRASHNELALLPRQSTTASHESIPVSDEELDEESHEQYRYKPDGLMKQTFSITTSTGQNLHLISYYSRSDPNVRNLTQPSFDLHLRHIIPLNAIYPESVLLQVHGQTSAYPEIQPLPHPSFQTTEIFLPRNMCDISLHQYSIDYPWPPSPKLTRNFSPNTNTLPFLNMLPTTAPNNQPTISQAFSSPQINQRTDLRNCENSPKSVLDKQILSLKLPIYASTQESPKLRPLINNHASCPYFGPRPAGENFYSTPMTLKPHLKSLHESLISNSHYSAMITNAGSFGLSGRIPSISSFIYANDSEDNNDIMNKYSRDEAASLADSWGGLDLGSNSWQHMDRSNLMTWRPMVTLDDEDHRALRVLDRKFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C6</accession>
    <name>A0A0B1P1C6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003258">
        <property type="protein sequence ID" value="KHJ31095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C6"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="568" mass="62856" checksum="5A2EBA2560828203" modified="2015-03-04" version="1">MEFSQESQSSSTESSQNPPPIPLIPPLPNSPSTYASPSQPSNSQLRSKPLVERAILKPNAPSKRPLPDRISKNSSENTGSVNTFLPKELVEIIATRQRHERAWHVRLMICTTVLSNIDSTLVNLHEEIEKEEEEAEAFKVYLRLAISNFVAADSSPTPPRVPIHTRLIKGNGNVKGKEIDRNLTKKVAVATPRIILTQVPSREINKNAELPKIPQSGDNSWATVARKGQKKARINLSTTARLAPLGKTYHCSNNKDKSENLTSLTKAMSDSRIFLRLPQDHEWRKLSPAGVREVMVKKLHISPSIISRIKPVHSGFALSPSNSEAREKILKAANGLFLPGAKLEPATNWVSVLVPTVPAFIQMEQGQVEVSKSMLSNEIERVCSVRPAYIKLFGQNNPKAPHGTWMAYFCKAPRSSFRVFDESGIMRPYKKQQPIEFCKRCNGHHPSKNCSRASSCGNCGPTNHNVDICKAATKYRNCGGPHRADSRRCLARPTRSGAPSKEQLKVCRQAGEREYQAVLRVRAAEEKAMITEKIIIDSTNSNLPEADSSSDIIQVTPDEVSTGVASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D6</accession>
    <name>A0A0B1P1D6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002086">
        <property type="protein sequence ID" value="KHJ32432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D6"/>
    <dbReference type="HOGENOM" id="CLU_2252051_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="104" mass="11904" checksum="400E97E5D4F382EB" modified="2015-03-04" version="1">MCKALTEKFIMEITAMISAPEAENLDVKKNVENLHLGLHSTFMARNGKFIQNFNLSRSSIDSSPSQVQQTEGIKNRLCLPTRLPVSKNLKNFLQRLRLQLLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1K4</accession>
    <name>A0A0B1P1K4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dna-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003747">
        <property type="protein sequence ID" value="KHJ30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1K4"/>
    <dbReference type="STRING" id="52586.A0A0B1P1K4"/>
    <dbReference type="HOGENOM" id="CLU_012849_2_1_1"/>
    <dbReference type="OMA" id="LEYYSEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="640" mass="73181" checksum="3B6F337D9532F927" modified="2015-03-04" version="1">MSEIKYSNEQRANDSNFKILPSDVETDVKENLQTSSFINSEDSPRSSEELSAKKRKRILEKYELKSKRLKPFLNHDYRNILNLEIQQISARVSQDDLYAFQESQIGSSIWTVMEKSLFFAALDSLGKDNIRGISVRVGSKSELEVKEYLLVLEEKTRSMVSYSSDLCTLVEIPAASEISDNCCALIEKAADALAAHEEYKEAKIEEQKWDDLWIITQNYTIEFGRRRNRFKHLKSMKELKPILDLFILRNWFLLTENIFMNSSISEENWQTFAEPHERPAFRATALEDFYSLAISVTKRLVSATIFCTMSRLRARGTIDSKLTEVNLDDAKAAIRTLGSKSNSDKFWTHCARRCKLSVVDEKENCMTYDEVESVMTSHVPQCSESNYDNIVLPSHDPEFFNPALTIDREQFSDHQIFDSDLVISSDEMSDELNKISSVGKEEIFNQTAEKQKQAAEEVEDIEVETIDMRSSHAEEQNLMRILKVVPTYGCDDEKLLTAGQSTSKFTRDIGQRSDNWREKLEYYSEWETLDTQIHNKSFASNRAQTLVVTNQKVSPKLVSQLKNDLNHVTIGSNEYYNKPESDLLHSNHSGPALESDNDETNTVSSISFDETIAQLRGLAANFQPSSGDEFEDFMVETGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1V2</accession>
    <name>A0A0B1P1V2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sac3 ganp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003039">
        <property type="protein sequence ID" value="KHJ31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1V2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1V2"/>
    <dbReference type="HOGENOM" id="CLU_015513_0_0_1"/>
    <dbReference type="OMA" id="RAYKPDV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000006">
        <property type="entry name" value="Putative SAC3/GANP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="336"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="495" mass="56453" checksum="BB014843FE4E4071" modified="2015-03-04" version="1">MNSIWTNVVSSAKTQETRVTHNRPSYHSVQVRQSLHSSFPQSQTVMPSPSAAPISEPPPTRKKIDWPQPVRSYVQRSFDTSNLLEDVTRPEMEAKLKETITAATDQDKLDKIDWDNLPLPQHMIRYQRAQPGWQQSSLESRIDRGNANLVTNSKKRKSLDLGNNKDNNQLLISANVSNGVEKNIQSKISDEKGTSKLQKSLEKRQRRFDGAYKNYRVSPSPEPTSGPVIGTCQTLEKRYFRLTSAPNPSQVRPEPVLRKTLDFLKKKWKKEENYSYICDQFKSLRQDLTVQHIANEFTVSVYETHARIALEKGDLSEYNQCQTQLRILNAQNLGGNVVEFKAYRILYFIHTSNRTALSDMLADLTTAEKEEPPIKHALCVRSALALGNYHRFFRLYQNTPNMGAYLMDMFIVRERLAALSNICKAYKPDVKLRFIVDELGFESDSDAAQFICDHNGQHLLEEKSDSFHVLTGKAGAIFEGAKILAFRKVDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P205</accession>
    <name>A0A0B1P205_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cytoskeleton assembly control protein sla2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002210">
        <property type="protein sequence ID" value="KHJ32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P205"/>
    <dbReference type="STRING" id="52586.A0A0B1P205"/>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="812"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="314"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119273" checksum="9520A38D27465354" modified="2015-03-04" version="1">MNYATTTRNVDHSKSEGELANSIRKATSTEESAPKRKHVRSCIVYTWDHKSSGAFWTGMKVLPILADEVQTFKALITVHKVLQEGHPSTLREAMNNRGWIDSLNKGLHGEGLRGYGPLIREYISFLMSKLNFHGQHPDFNGTFEYEEYISLKGINDPNEGYETISNLMTLQDRIEQFQKLIFSHFRNGGNNECRISALVPLVQESYGIYKFITSMLRAMHSTTGDDGALEPLRVQYDAQHYRLLKFYYECSNLRYLTSLITVPKLPQQPPNLFTEDESAPRPPQRARQEVERKSTPAPASKLEEPDEIGEFWKIEQARQTREYEEQQRMLEERQAQQLFSQQQAVIQAQREFEEQQRLLAEQQRRDQEALLSQQFQQQTQGRMAQLEQENLEARAQYARDQLMLQQYDQKIKLLEGELSQLQGNYGQQMESKDDQIRSLQEQVNTWRTKYEALAKLYSQLRHEHLELLQKFKGVQLKAASAQEAIDKREKLEREIKTKNLELADMIRERDRALYEKDRISGSNHEEIEKLKRELRMALDRADNLERSKGAELSSIVSKYNREMSDLEEALRKKSQALDDIHEKYKEGGSDAERLLREKEEELEVYKQSLDDSLIKLNELEISRGATDQALDGEIDAMLLSNIRKINDIIDSVLQTGVQRVDDAIYELESSMQAGNQNATPPYVLSQIEKASSSAMEFATSFNNFIADGPNSCHTEIIRTISIFASSVADVVSNTKGLTRLAIDEKKGDQLTNSARQSALSTIKFFRGLQSYRLDAMDDVQKTDVVINSNNDVLINLQKLSKLVDLFVPSSVKLAASKEDLGDLVESELNKAADAINAAVERLSKLKSKPTDGYSTYELHIHESILDAAIAVTNAIGKLIKAATATQQEIVQAGRGTSSKSTFYKKNNRWTEGLISAAKAVASSTNTLIETADGVLSGRNSPEQLIVASNNVAASTAQLVAASRVKAGFMSKSQESLEEASKEVGAACRALVRQVQSMIKDRDQGEEQVDYGKLGAHEFKVREMEQQVEILQLENCLAAARQRLGEMRKVSYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P286</accession>
    <name>A0A0B1P286_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002880">
        <property type="protein sequence ID" value="KHJ31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P286"/>
    <dbReference type="HOGENOM" id="CLU_1397272_0_0_1"/>
    <dbReference type="OMA" id="SACCASW"/>
    <dbReference type="OrthoDB" id="3592557at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="195" mass="21294" checksum="7DE6C4FFB0A194AE" modified="2015-03-04" version="1">MEEKSIRITVTEASSINEKSESPEQEVSQMSEIKSLSTLSATPSSNNKGLTYPPPLDLSAQQNTLADNLKSLSPTDLKSLTIVSHRSFDGDLESQNFDTNQTQSSVSNTGLLHKSSYDPMWPNRHELKLKRKAMKRERAFCSWWADLSRKQRGIISTIVILAILGAGLSVGFGISKCVGGGVVNSKGPNAPVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Q4</accession>
    <name>A0A0B1P2Q4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome c oxidase subunit vib protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001983">
        <property type="protein sequence ID" value="KHJ32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Q4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Q4"/>
    <dbReference type="HOGENOM" id="CLU_142408_0_0_1"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="118" mass="13692" checksum="7B651E625DA81DC6" modified="2015-03-04" version="1">MRFSEIFGSSVSSPKISSDGAPIAPDRTQRQKCWEARDAFFKCLDQHEIIDSIREKEKADKFCNLEEKPFRTECASSWVTYFKQRRVAEWKKAQTLERLKAEGAVRIEGELPPLPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Q9</accession>
    <name>A0A0B1P2Q9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003434">
        <property type="protein sequence ID" value="KHJ30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2Q9"/>
    <dbReference type="HOGENOM" id="CLU_348236_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="810" mass="93634" checksum="5D3511F30E081AED" modified="2015-03-04" version="1">MTEADADQRKRSAERNFVLSWLNQTNEGNLGNILNESLQRIHSHDYIQKSLKRKIKPVASFDSSIIDEPMRNNLEHDDENTEIKQSEMPDHEGLNPWKSKKTKYDPTLDKDSHQPVPFTEVAFCKRMRHKTREDRYDINKKRMIKHKPVNRTSEKSRRNLRKSNKIHKHVHSFSSKKIGADRLTLRPSNNRGIFKNGRASSPVTRRGIPDLSFSEMEFLRRSSKVSLKENGGRVQARFKNSEKSDEISAYFKASKVSIPLNNNYHLRSPNKMIRQSKSTRKSNGFSNMNIKESILCRGASIELPLHHPSKLLSPQSQSSMNNYSSSTAKVNSSLSENQHGSQNELSNFIRSDRNENFFMEPYNSFKSMTSNYQQLLNKDIVNSNEQANVTLNENMELINLINASSDEKMQQTSNITNIANTCFDAKCNMNYDVELGSKRYNEGDEIKNKNIKYVGPMNMCDSGKGMKMAQKRETVIHWNENILKNLTKPIHIKRPSTTVPILSVSPKNNFSAKKIQNHHDQIDTKLTSSHFDNFYEQEKTEISLSHSPACHLSKKIQRHDLKTFHHDRLSQFEVSKQNLNEKLIWECPFKNIENSKNPPKDEFSNRYTPEISIDKQNEIFNNFQYQSIASPNLLANIFSPGILRQKEHILEEKYQFLSQLEQCLDSNESSYFPGLFSTTNAGFTQPLPLAEDTQSTGRKQKFCDDSDQLEEQSININEKLYYYNYFNDLEVLDKGSLDYIGGENQGFQNETATDLSLLNSSEVHEKPLIATITTPYSTSRPETFEYLLQKNRAVEEHNDLGRFWDVHRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2S7</accession>
    <name>A0A0B1P2S7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative heat shock protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g6243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001965">
        <property type="protein sequence ID" value="KHJ32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2S7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2S7"/>
    <dbReference type="HOGENOM" id="CLU_046737_1_1_1"/>
    <dbReference type="OMA" id="AWWTNER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="71"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="26513" checksum="1A04C3FE88E6EB5C" modified="2015-03-04" version="1">MLSKTLRPLPFRPLRVLKPSRTASLPLCARRKISFFPRAIVTNENPVFPPIFRLLDEFEKYSRSIDQPSRSFTKDFTPKFDVKEVSDSYELYGELPGIDQKDIDIEFTDSSTITISGHTVRSHTEGQPPRDLIENKSSSDSDSVTAQDGNTKLSENPFEKEEKTSDNQNISEDSREKFWVMERSMGEFSRSFTFPIQVDEENVTATMNNGILRVKVPKAKKQAGRKIQIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T7</accession>
    <name>A0A0B1P2T7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001678">
        <property type="protein sequence ID" value="KHJ33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T7"/>
    <dbReference type="HOGENOM" id="CLU_1001822_0_0_1"/>
    <dbReference type="OMA" id="HEGETME"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079680" description="Reverse transcriptase Ty1/copia-type domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="164"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="278" mass="31814" checksum="D4B4F770C4612380" modified="2015-03-04" version="1">MAVKGYILKLFFLPSLTQYLVYVPSKVGSNKVIKSANAQFLEDSFWDWDNSTKDLSEFEVLSNEVHTFINTEEDSEIDSDTDNDSQATSNTAQSIPSSTSDSSLNEFESITVDEDISNQSSQNILTHVNREKPTLRRSSREQWKTVIEEEIKSLKDKGVFKPITHVPRERKPVGSRWVFAIKADRRFKARLVTQGFRQVYGVDYFDTYSPTFRMASLRILLATAAYREWEIHQVDVKTAYLEGDLDEEIFMTCPEGMKATKFVKVNKALYGLKQSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V8</accession>
    <name>A0A0B1P2V8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002694">
        <property type="protein sequence ID" value="KHJ31660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V8"/>
    <dbReference type="HOGENOM" id="CLU_2414934_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="92" mass="10457" checksum="C1DEFCCB1109BF4F" modified="2015-03-04" version="1">MTQEFATTNNDVSVAVPLDIYLVRTLYDAHIEMGSTLWMRGTGQHDQLLNRGVIVNHSQAVPKRIRKADHRSWLKVNPVTQDSENANPRTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2W9</accession>
    <name>A0A0B1P2W9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001937">
        <property type="protein sequence ID" value="KHJ32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2W9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2W9"/>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="OMA" id="KYTVFDR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="110" mass="13097" checksum="CFE57DC62917EBF2" modified="2015-03-04" version="1">MLGAFNRTNSLFGGLLWKIPWRLSKFQKARQRKRLRAVDNVVSVVDKALAKQGTTLKSLEIWKKVMPTEQEMLPKDKYTMFDRKEKKYRKCLRKLPKWTRVSQRINPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X3</accession>
    <name>A0A0B1P2X3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2367</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="JNVN01003061">
        <property type="protein sequence ID" value="KHJ31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X3"/>
    <dbReference type="SMR" id="A0A0B1P2X3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X3"/>
    <dbReference type="HOGENOM" id="CLU_014881_1_0_1"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="503" mass="55665" checksum="A66B3C6C241034EB" modified="2015-03-04" version="1">MLTRHGPSPKPFSGLCKVRKTIAPALPSLLPFHQNRGLATVQDTPINKRVYGGLKDQDRIFQNLYGRHVVDLKTAKKYGDWYKTKEILAKGHDWIISEIKASGLRGRGGAGFPSGMKWSFMNFKDWDKDNKPRYLVINADEGEPGTCKDREIMRKDPHKLIEGCLVAGRAMNCSAAYIYIRGEFIQECKVLEKAISEAYSDGLIGKNACGSGYDFDVFIHRGMGAYVCGEETSLIESLEGKPGKPRLKPPFPASVGLFGCPTTVANVETVAVAPTICRRGASWFSSFGRERNSGTKLFCISGHVNNPCTVEEEMSIPLRELIEKHCGGVRGGWDNLKAIIPGGSSTPVLPRSICDDQIMDFDALKDSQSGLGTAAVIVMDKSTDIIRAISRLSHFYRHESCGQCTPCREGSKWTEQIMKRFEKGQGKPREIDMLQELTKQVEGHTICALGEAFSWPIQGLIRHFRPELEARMSEYAKNNNGYPLVGGWESNALQQGKLIAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X9</accession>
    <name>A0A0B1P2X9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative c2hc5 finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001655">
        <property type="protein sequence ID" value="KHJ33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X9"/>
    <dbReference type="HOGENOM" id="CLU_027500_1_0_1"/>
    <dbReference type="OMA" id="MWASPQE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="57620" checksum="D4E14CB74D3BF76F" modified="2015-03-04" version="1">MSLTQLSQLLPLPIEDLQQILDYTRTLSSDEAADHLNNLLGQSSQTTKFISDFNSSQKGDIKNLSSPTSKNFYSSSTKKSNEKRLQLKKREVKENLTYGNPYYKNDEENYIGTSKKTVVDKTNSKNVASSRKSQSPYTVSSSGAAGTLISDSSYRQTKKISSVSKGSGSGSSSRSSNKTKISISGGKALHGESTVISELDAAIRALEISTNVKLNSQNLSRRTCNCIGTRHPILTAAPNCLSCGKVICIMEGLGPCTFCGVPLLSSAEVQTMISHLKEERGREKMISDNRSKKRAEIASTPKAFSTLKGNSSDFHIGEDQTSSAKIEAQAHRDKLLNFQAQNAKRTTVQDEVADFNIDEHEVRRDMLWASPLERAKALKKQQKLRQEIEWQAKPEYEKRKVIVSLDVFNGKVIKQIRNTVQEREDENTRVDRKSENVNTLTSPDETHDQKISQNFTNNLLIGNLVRPIWSAKVNQKAEIKKEESEKGFKWGVNNWRRVLDDQDDNEEIILDGGFSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P350</accession>
    <name>A0A0B1P350_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative tubulin-specific chaperone e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g2193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003247">
        <property type="protein sequence ID" value="KHJ31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P350"/>
    <dbReference type="STRING" id="52586.A0A0B1P350"/>
    <dbReference type="HOGENOM" id="CLU_017716_3_1_1"/>
    <dbReference type="OMA" id="SEESHMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="592" mass="67160" checksum="17F9EC843FA3B4FD" modified="2015-03-04" version="1">MREYKIGDRVSYTTKFGTSEICTIRYIGEILGYQGSWLGVEWDDGSRGKHDGSLDGKRYFSCKSLSSTAGSFVRPSRPSDPERSFIEAIYDKYVALDTTSAPSKSLGKEIIISGKVAQEVGFDKIRQIQSRLHEMKIVILDGMRICIAEREHENIDEICPKIVELDLSRNLFKSFAEICLICSKLPNLKKLSLRGNRLSDIEVKCSGIAPEQAASWFSNITKLELDDMLISWESIVSLRNYFSELVTLTASSNYLKSLPCQLKDDNLVSLALENNEFETLRDLYPLTKSKSLRTLLLKANKISKIASNLNDAIGIKFSEKLEYVDLSYNAIDSWSFVDELPIVFPGLTGLRISNNPLYPTPVQSPSIQDTEENFMITVGRIGTLKTLNFSKITTTERNNAEIYYLSKIAQELTEVSEDNVDIVLSRHKRFKELCNEWGPPIISREGAKSHDPVARVEGRLINFTFKQLNINSKEDCMLTIYREIPKSIDVYRVRGLVAKLFGISVLDLRLIWETGEWDPVAGYEFDEIQNSDTDDDTAFTENDICIKKEMVRRKDKNSRWQKREVEIIDSTRQIGNCIEGANAVVRVESKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3A1</accession>
    <name>A0A0B1P3A1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001591">
        <property type="protein sequence ID" value="KHJ33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3A1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3A1"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="334" mass="36948" checksum="6FA03388A111DEFA" modified="2015-03-04" version="1">MKKARVVSCNNTKASTGNKNASRVFDKDNSSKPVSEKRRFVRLPQDHKWRKLSSAGIREVMVKKLAISPTLIGRIKPVNSGFALSPCSTEARDKILNAGNGFFLSGEKLEAATNWVSVLIPTVPAFIRKEQGVVEVSNTLLADKVERVYSVRSANLKLYGRNKAEAPHRTWMAFLSKAPRGSFKVFDESGVARPFKKQQPLEFCKRCNGHHPTKNCFRAPSCGNCGSTNHPKDLCMAVTKCRNCGGPHRSDSRRCLARHTRSGAPTKEQLKTYRQAGEREFQALLRAKAAEEFAATVESTNDNVISSQVTEPESNIENSLAPSVDNPTDDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K3</accession>
    <name>A0A0B1P3K3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001541">
        <property type="protein sequence ID" value="KHJ33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3K3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3K3"/>
    <dbReference type="HOGENOM" id="CLU_014251_1_1_1"/>
    <dbReference type="OMA" id="AQDMVML"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080451" evidence="1">
        <location>
            <begin position="19"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="2">
        <location>
            <begin position="163"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="750" mass="84047" checksum="DFFD1CD8F5CA3008" modified="2015-03-04" version="1">MKIYLISLILLALDPVESFPGSHVKGYRNPTAVIEAPCARVSASSSATLRHAPKATPTVSAQLAYECLTSVPLNQDEAVALVKAILPYVEWQSDLSFLKNPPPGYLMPAVDVKKELNRVLNHIIDGKYENEHAFQMDLFKVFQSVHDGHFRFTPDLLGKTLHFRRSVGIVSVSRDGVEVPKIYIESEIKQYVNNSISFMPSAVTKIDGKDATSFIYDLMIQNSQHDPDAQYNMMMYGKAYDTRFPDFGYKGLFSLGSRLSYFYPGPSTTIQFENGTVREFENYASVIGDFDGVTDGSSMYQKFCSGPSKNKSKVIHKVKPTATPTSNKEPSILPTDNEPVEGYPTPHIISSDKLVSGYLLDDPNHLDVAVLVIFSFQAKSVLQTQSVIQTLIAECLSLGKTKMIIDLSSNSGGNLVVGYDTFRQFFPTIEQPGYSRFRLHEALKIITKQISKIASNFSFTSTNPTDYDYYQTPFNYRFDLNETNEKFLSYEDKFSPRKFNGDEFTSNMRWDLEDPTMTSSTWGSGINVTGYGDRKNFIQPFKPENIILLHDGVCASTCAIFSEFMRLEAGVRSVAMGGRPNKEVIQGIGGTKGANSYSFESIHSIAHQALDFGTPEQVANWTALTTLSTLPIRRSTDSGINVRDQILRTNLEDGIPAQFIYEPADCRLYFEPNMITDVRAVWSKVASAVWGNTECVAGTMKKDKKAEFYQPEYLSMRPEEVKTYPMTLEINTSDESQRIFREDFATAKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3N5</accession>
    <name>A0A0B1P3N5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002785">
        <property type="protein sequence ID" value="KHJ31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3N5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3N5"/>
    <dbReference type="HOGENOM" id="CLU_2110756_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="115" mass="12895" checksum="F8B3FBE5A549789C" modified="2015-03-04" version="1">MVTSNFNPCLLITTDENPKFEFGVVGMQTDDTLIVSSNIKIHQKVQGLKLRTTDILASNQAQQYLEQRARGAYIASICQPEVSYDLSVAVQAQQSTNEKVAKLNARLQWQMNNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3T3</accession>
    <name>A0A0B1P3T3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001704">
        <property type="protein sequence ID" value="KHJ32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3T3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3T3"/>
    <dbReference type="HOGENOM" id="CLU_035522_0_0_1"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="40621" checksum="45E3F5A7BDEB7420" modified="2015-03-04" version="1">MTTTVIVKTPDQVERPSRRRPFSTWMKKLANLKSGSSTAADNNQTSSKKRNNYSAKNNPKKLAFPLNINLRSESPYINGDQVTEIVTQSSSTLPSANLSGSSIDQDDTSQSFDDGKPPTTGNKSTTEASTGRANSVVAPSNAPSSGQGTNGTIGYGIRGNDSTFSSPAPSVRSLTTTLTTLHSTAAMVTTPNNPNNNYVAIQFSHQFPSSSQLNALPSHLTPQSGGGHLSTYNTATANNLLTDNASILTLASSSKRRRRRSMDTDASVRALAPSSLFGGSRESLPLSVLSTNIEQNSHQQRPSIGGLNERGSIYSVGGVVSTLSSERNSYYASKQPVSADNGSLLQNSPLTSPRDFLASNSGKLNQSETIQDENKNENKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V0</accession>
    <name>A0A0B1P3V0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001700">
        <property type="protein sequence ID" value="KHJ32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3V0"/>
    <dbReference type="HOGENOM" id="CLU_339542_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="837" mass="93861" checksum="015920B5F2AE829A" modified="2015-03-04" version="1">MNRFRKKKEARDAPDGSSRLSIDSDTSVIPTTRKAFRLGKKTLEPEPKSKIDLATALPSSDNFRTSLLMNGLSARFSMLREQDDPNSKLGKASDDSVMFSKRMSRFNDFGLQAQSLSDIAEDSSVHSSLRAPHEIERVVSNASLPCYNINKNSQSNRSIMNRSRPGEGNNLFGGRLKINVGNRVLYDDDVRLSAYQRQRRAEKDRSRPQIGLQGSHITTHAVESSNYNNFNVRVISTHSENCEITPNSATSLEKRGDQKIKPSSDINGSPEGRTCKIRKLYEAGLDNRLHEQQFSAMSKIDTLTRRAAVTGTPSPGPSPLNMSSNLNIWKNPQANAPSYTSLHSSISTKAPTYYNSHKDEFLSPPLTPYDNDEEYVDSCCSNVSYRSPDSETKNFHQSHDKSLNSSGYGQNQDDQNSLKSKNSSSKPLIDVNINHYRNRSNSNHGSKNSDINSVNSGYHNSDRRNCNLSDPSQSSLSLKDSSQNSIATCSFQESPHNSKNPHIDSVDVKLHLLELSDNQSADNINADQFQSHKIICNPSLDFKETELFNKSSRSSNSEKVLGSFGTERGSSNEIIGMVRQHIRYQSNTSSIYESPPSTNRPNLLSQSSSTFLHNDYLAQSNPWKGDYDDEKIVIPIEEPFLRYKNSNEIAKSSKSHVDDEKIVVSSEETNVKTKSDVKNTSNSSSVRYHIGHYFNADVKPSETNPKSKYYDESVDFHDENLYLSSAKYDNGSSYDINETSSVFSDGKEPTFSHSRHDSTDTQREQQDLKTQLASRRLYVQEKMKSFVESDNNLLYPISVHEMPKDGPLKNGVFGMLRTKSSWASVKPPKRLLVSRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X0</accession>
    <name>A0A0B1P3X0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative trna methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001480">
        <property type="protein sequence ID" value="KHJ33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3X0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3X0"/>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="OMA" id="SERCMPK"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="523" mass="58496" checksum="32C573FABFFE8166" modified="2015-03-04" version="1">MLYQTLEMVGDLLIGARGSYLDLINFRDTTLVSSWKCPLTCSKQNQQELQDDNKLNKGSEILDCAVESNNSPPIKKIKLSQSKNRKLDTSFNHTDGSEPGCLKDQNNLFTIDSPNISLLTSTNDGKNVIIVTREDKSIRVLEIIGTGNSRELIQLSQRPMPKRPCAFAISDDNLTIISADKFGDVYSLPLLYLPKTTVQESAPESLDESLEPKLAYFTPAASELTVHSERNKKALESQRKQKYQNSQKQQISFSCELLLGHVSMLTDVKLAKVGGKSYLITSDRDEHIRVSRGIPQTHVIENYCLGHTEFVSRLCIPETKPKILISGGGDNELFVWDWVHGSLLSKTDLYEHIKNVRKKLSAELNKNETMNSQIKVAVSGILHVSLLVDSKVVSLILVSCERLPAFFTFCLSPENKLEYSETVWTSGNILSMSTASVQNSMVKSLFVSIDNLHKPGSSLDIREDISSILSLCRFDFDGVNLKSIPLIFKVPVDKEFEGMCKNSGQISDLLYSIESLRKKYDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3X8</accession>
    <name>A0A0B1P3X8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001689">
        <property type="protein sequence ID" value="KHJ32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3X8"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31171" checksum="DE800F14AC159E0E" modified="2015-03-04" version="1">MAPPLGSKRGLPSDHLDAGSRVSKPTTTTYKPSRIRKAKALISMANSNCSTRSNLIENVLSKAHGSTSKADYDTGKENETGCVISTEEFPPLPKESTTEVNSSIDSPSLQVNDDKKNGTAPLMAAIKGLLDLTNEYLQKLEEQQPGIGADFLAMRGERVYSNISGSTDNHHHARQDTWAKKAGSQDAGIKVFNLKRQILKSSAPQWQSKEDRWVMIRLGPENEARKAGVFELRQKIQELVSDKSLVSDVWSIPSEVAILAPTLAKAASIMQSKATIDERLGNATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P456</accession>
    <name>A0A0B1P456_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P456"/>
    <dbReference type="STRING" id="52586.A0A0B1P456"/>
    <dbReference type="HOGENOM" id="CLU_004379_1_0_1"/>
    <dbReference type="OMA" id="NNDCHYL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000037">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="586" mass="67166" checksum="62D2EC2DF292E02F" modified="2015-03-04" version="1">MVQSQKPEFEERRSTRYLNKLFKHAGNSKILEKCNIKKTENKLCVSVPLSRELKNLTDTLEYAKIDIVPIIHEIWSNGKLVNGDYPRKKNQLKKDESTLEAFDEHIASFRTELMGKRRKLWLNKGLYAGQDDCSDWYEFSLNNIKRKTRSHSSKKPNKALPLPMWHGKRLIEMGRDFKLPFDVCSPLPPGQPKPDEWRKTTKNRFVGEAGALWKVSKFLYSSSSKCVCNPELGCDDNCQNRIMFYECDDSNCASGPSRCTNRPFAALQERRKAGGKYRVGVEVIKTIDRGYGVRSTRCFEPNQIIVEYTGEIITEEECDRRMREDYKNNDCHYLMSFDQSMIIDATKGSIARFVNHSCKPNCRMVKWIIGGYPRLALFAGDEPIMTGDELTYDYNFDPFSTKNIQKCRCGNDNCRGVLGPRPKDLKLAKEMEQPKIAVKGVMASSKRKLKESSGDYAELESPISKKRKTEVGAFSGVSCSSFSKKNVKSNDEDIPQKILRKGCLNNSGCIIKKTKRSNSLDFRTSRNQKNSFFEHDTNSVTTQLDTPTRCLRSLKSRKMPSNQENDKTRSLMTNIPASKRKRKSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P486</accession>
    <name>A0A0B1P486_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001397">
        <property type="protein sequence ID" value="KHJ33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P486"/>
    <dbReference type="STRING" id="52586.A0A0B1P486"/>
    <dbReference type="HOGENOM" id="CLU_537700_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56940" checksum="F697277F261C9D3E" modified="2015-03-04" version="1">MARHCTNCGRDERHSYRACPNISLTIDEKNTLYNMIAKNLNLRFFGVEYPEVRSIQAHHQRNQDEMLERSYGPPCPMTPIYRSMEVNKDDDFENWPTVEFENLTGIIEGQGASGSRSAIFSNLHFSTASNQAESPLIGKKNSAAQINKRMNQIKQAQPSKSFGLSVGPYNSPEELEVSRAISELQIIGGQVSETNSVVVPKEFKPLSINDIFEKAVLEVQAIETSRKRQRIDVEEMLNQDDDHQFQPRAPKKSKSQTGKRTTLIDELDSELSEAIDKKKIRQLNEIDGHEGLGPIDYKDMLAQIRVNLSILDLMQISPDAAKAFKYYSTRRNQKGGKRQPQSNNFNTDVQISSDQTAAPRGIKQCERPFRLLDATIVCPNLKTKTILNMGATQADQGSDINLILDLLVSTLSLKKREIPGVGGFMMQTADGNLTTLRMFAVFKLGVAGIWRTVHAYIRLKPRSGTDTISLILGLPWLYSVKATINIFEIALQLVTLLIIPKMERGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4B2</accession>
    <name>A0A0B1P4B2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002829">
        <property type="protein sequence ID" value="KHJ31509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4B2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4B2"/>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="257" mass="28954" checksum="4ACC277EA75524A5" modified="2015-03-04" version="1">MGRGPKKHQKRLSAPSHWLLDKLSGAYAPRPSPGPHKLRECLPLIIFIRNRLKYALNARETKAIVMQRLIKVDGKVRTDTTYPAGFMDVISIEKTGEYFRLIYDTKGRFTVHRIQSEEAEYKLGKVKRVQLGKGGIPFLVTHDARTIRYPDPAIKVNDTVKIDLATGKITDFIKFDTGTIAMITGGRNMGRIGVITHRERHDGGFNIVHLKDAIDNVFATREGNVFVIGSDKPWISLPKGKGVKLTIAEERDRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D0</accession>
    <name>A0A0B1P4D0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mitochondrial large ribosomal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002823">
        <property type="protein sequence ID" value="KHJ31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4D0"/>
    <dbReference type="HOGENOM" id="CLU_057182_0_0_1"/>
    <dbReference type="OMA" id="ERHTITD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="37211" checksum="D791EB5C7E814B64" modified="2015-03-04" version="1">MSIFITSQQVTRNALNVVTLSSPYLIVQRRSIWFFDRFKKRNSDNTGKNTIPNPLTEEFLTRKVSSPKLVRGGLAKSSILEDEEVVGPKPEKIGTQDDYGTTIRNPWSMAAVLDPSPHSRRRWERKMVIRDIRKRGRLTKAQQIRRTERESVCKSHDFKTSVKKLVHLANQIKGKTVDDAIIQMRFSKKKVAKDVKEHLEHAKNEAIVRRGMGMGILPGNEFKPLTITTNDKKRVRVIDPTTIYVDQAWCGKGLFDRTLDYRARGRVNIMRNPTTSMTIVLKEEATRIRIQRDRELKSAKKKTWVQLPNRPITAQRPYYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q7</accession>
    <name>A0A0B1P4Q7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative filamentation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002484">
        <property type="protein sequence ID" value="KHJ31916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q7"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Q7"/>
    <dbReference type="HOGENOM" id="CLU_003276_0_0_1"/>
    <dbReference type="OMA" id="KQPPEQD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="833"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="778"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1187" mass="133478" checksum="382C0BA9F66BF87F" modified="2015-03-04" version="1">MSREQTKSSSFIQKLDEARCHGEWNALPELIRKIKKHAPQRVCLTLTAESEHATALEIQQFINGPPLPSSLSTSNSTNKLLSASKYINQLKDAIDKECTYAEDKFQAQVCLSTIYWLQGETALALSSLPKEIHEEFSQTGNNIKESPRSLRLCFIKASYIKGILLQKESAHMEALFVFHSTLPILSKSSISTRQDHEVRLWTELFLIGACTLSSDILKKSYSPELIKNTLIAFRLWSKFWNSSKSVGGRLSLADFCRRDVWKEYYIILSKLLEKGLSFDIEKLSTSSNEEPPRLQQRAELSRVEAYYESLLMAEIDFPKADEASQEVEEFVEVLMRNWRINCGIEKSNQGFGDIGIETISRGVLEILYRAVKKTFHSTSILRHLFTVHLVLGEINLAFKAFDIYLVTVMKGKSRVEKTGHKAAGLDDDDTVLKVASEYIKALCRYGSYEFAEKANKTSMFFEDWLETRYSIDSNEGKNSSIPPQTFALIWRCIGIGYAQWARTTFDAVSRSDVQSKAIECFNKSLLPQFQSSNNPETLFALGCLLAERRQIDAAIRAIKTALLSTSSKEARIEHIDRSRPYDRERFSISLWHLMALLLSARQQFTLALKSCEGAFELLNNPLDTSLGGVSNENKDHPVDEIQKIVNEMDNSERENLLQIKMTQLTLLELLEGPDAAINESYEVLSLYTKLFGEPRTDQTSVDGALLSIPPKSSTGRSFRESILNCSVRKAHDDTSDDQSTPINAPLIHITSDNTRAEKRQSFPATAANSDEKNKEISFSHSKTTENSFNHNSTPPLGSQNQSGENIRRKSDTMNQEQLVLLTKIKTHRHMFSTSIDKSAPSDTTQASTHMTSSDVTSKKLVKSIEPSDSQENHQNPATPKLSSCFNPAIVYSKKEQKRLQITVLIKVWLLIGGFYRRASMYDDAQGAIDEALQLVNLIEFNLLNDPKSSSSCSNFKWEGGKTVAELRSDIYSELGYLAIEEGSPHSAINHFESALLHFRNHPNAIVGLSNILMDIYTKKLLIPSLTTSVNLNTITPSLSSLDHQKQNLAPTTSQNQYIMSMTNSRVSRDILNPVAVTMSDNSKSENSPRADISERISFSAHEINYKDPSPALLNRLAARDRAFGLLSSLTKTGLGWNQSEAWFALARAYEESGQLEKAKEVLWWCVELEDGRGVRDWTVVNCSGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4V3</accession>
    <name>A0A0B1P4V3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002153">
        <property type="protein sequence ID" value="KHJ32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4V3"/>
    <dbReference type="HOGENOM" id="CLU_921949_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="35109" checksum="B2AF02057AF9E5AE" modified="2015-03-04" version="1">MVNGTMEYRNVCWRCGNGPNADSPRHDSRQCQNPSLQNWESEVLCCKHHERKEMFEIKENQIGNMPHNSKKPLTNQVVDVDLRRERYEKANLTVPYLNNDWQQSDEIEEMSFNELIAMESASGGSKTHVNVVDGPLDEYLLDEPLAEELTSTTYCKKGKYEKCKEEDLLTEAQILFSAHVVERDNAKRPRTHHNIINDEDIEPRPKESVGVDEFALYQGKNRPRRRQVEPLINARIKDGPLDYMKILDRTKVEISLKDLAQMSPAVRKHWKHGMSRVNDKRSRKKSRQAEIFEVALKLPIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P582</accession>
    <name>A0A0B1P582_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative tyrosyl-dna phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002333">
        <property type="protein sequence ID" value="KHJ32106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P582"/>
    <dbReference type="STRING" id="52586.A0A0B1P582"/>
    <dbReference type="HOGENOM" id="CLU_010413_2_0_1"/>
    <dbReference type="OMA" id="PLIKECW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106334">
        <property type="term" value="F:3'-deoxyribose phosphate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="390" mass="44200" checksum="0A0BAA808E3A0F97" modified="2015-03-04" version="1">MPEMFGTHHSKMFVLFRHDETAQIIIHTANITEFDWTNMTQGLWRSPLLKKLSKNSPETSVSNDHSDGSKFKLDLLNYLKAYDNKSRKKICEGLSKKLEPYDFSSIRAALVASVPGKHVIHGLSRTLWGWARLQDILRSVDVKNCSSKPEIIIQVSSIATLGTTNEWLEKTFFKALKSVKNDSKDKVTEPEFKVIFPTNDEIRRSLNGYDSGNAIHIKIHTPAQQKQMQYLKPLLCCWAGDGTTPRELASNSRNSDAGRKRAAPHIKTYIRFSDSKKETIDWVLLTSANLSRQAWGDSINAAGIQRICSYEIGVLVWPSLYGTRAKFVPTFQIDKPSLNVDQENNEIVIGIRMPYGLPVISYGDDIEPWCASSAHTEPDWMGRFFNSFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5W9</accession>
    <name>A0A0B1P5W9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002209">
        <property type="protein sequence ID" value="KHJ32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5W9"/>
    <dbReference type="STRING" id="52586.A0A0B1P5W9"/>
    <dbReference type="HOGENOM" id="CLU_024203_0_0_1"/>
    <dbReference type="OMA" id="FGEAMHW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="39453" checksum="AF59293DBCD41DB1" modified="2015-03-04" version="1">MSRDIDLSKPQQKSYGDESIPVISEAKSIVREEPWSIHVADPFLQSFLSSTFDPAEYLNFNLPSLDCANTSHSNKSGTPINELFPVAQNLVSQVSANSARLTSILTQLTDEILRSGNRLTYEVEILRENTLNISEALAGVLRNDLARFVPTEIENDPKKGSGNLETSNANLMVKNQDPSFLKELQRLTLVRSRLESVIETFGDAMLWSFPPSEVSTASSFLSVSGPDIGLGSDGISTEEKGHQVSKKIRNEVTELLNSDDPISGIRSAKKRVEELKELVIVWKGTSEERARHKFIESLARMVDERNKELLRDIEQDSRFRRTSRMSQDNDKSEDSKPLPGYGLISQLQKLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P681</accession>
    <name>A0A0B1P681_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002075">
        <property type="protein sequence ID" value="KHJ32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P681"/>
    <dbReference type="STRING" id="52586.A0A0B1P681"/>
    <dbReference type="HOGENOM" id="CLU_379906_0_0_1"/>
    <dbReference type="OMA" id="LIALMWR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="759" mass="87278" checksum="DBF95A5BFFE4587B" modified="2015-03-04" version="1">MTLRHASSLKVCPSPSLQIKIFSSRLTQVHLPLSSIYRRVHSRQYLKEQTTDTLSTCGISRTSINNPKWPKEINPYNKKEVSDEEIFNNQAYSSDLSKVQKIQDLRWRQLKFWLNLVTNYRFCHPRSIIQQPKRKNLVLRPRISNKDVRNLLQEITENGSMTQIHSFYTKKMMWLEFFAKVLYSHPTRALEVLEAFARILPKFLCIPQTAIADILHCIIVHYFQDAKSTESEDLMHVATRIIDLLYTIPSSLVLPLSDHCVFLLLSNLPRPYLEDFYVYLSKNNAKVSIWTIMQFSSRLAKAGLLDLAFEAIQRLTGTNCHLNRPNSLSVFTSVLHHSHHDPKIPSDTLKIFKYLISSGVKPNIFLYNVVLHSLIEGQEAQSAWAFYERMIQESIEPDVTTYSILLNDAKRRADTPTITRIIQIVRQHGKTSGYIITDIIHAIFLLHQKPLSQSKSNVEHMNSQAVFDQMLQLYVEYFKLDKLFKLIPGLSHAYKLSSNLDSSRPLWDPPAPTLCVMITGFLAIVDSIGAKNFYENFKNLVLTGHPAVASLVRTTYIYNVILMCFYKFEDRAKDAPDVIANMLSYDKENNIKDKSSETTSIASADHKTPKNNSNVNFSGVVPHSPAKPDVYTWSILVKIFMRLRLTRSAEKVLGMMVRRNIQPEMVTWTSLIAGYARMQDPIMTANAVNRFEEAGFESDDYILRVLSKVWQQKTLINEMEFPRSQKIKPVSPEWIDDLKDNLAVDIAENSIDDQLYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6I4</accession>
    <name>A0A0B1P6I4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin-specific protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002217">
        <property type="protein sequence ID" value="KHJ32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6I4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6I4"/>
    <dbReference type="HOGENOM" id="CLU_008279_10_2_1"/>
    <dbReference type="OMA" id="MCKASQV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="108"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="47304" checksum="4AE6FB7822FBB3B2" modified="2015-03-04" version="1">MSPDTSDAKFTAKRVLEELIQERPNKISKLTQYEVTAEIQKAEIAQTPSESGANVTMKSLKFNTSLTDKDVYVRHRRAVPFVSKVHRHRTHSRNIKSSWIGMPSSAQKGIYNPAVLCYRNSLLQALLHAPKVVNWLRSYHRSKICVRGGISCVACHLLAVFNSYWGSTPSELLQATKELDKVFISTGWQDGRTGRQEDPEEQLVWLAKVLSQQLPSIQFDAFEAISRFILNSTTKCSSCGYVSTNKGEVEGTISIDLQPRIKKGTIADYIKPYFCHRVEGFKCDHCSSMSSKQRTREIYHQPETLVIQLKRFGWDGRKDSTPIPFSSNLSLNHYRSDVNKFSCEYDLSAIICHNGGIDSGHYVCRARGPDGHWMKFDDLQVTEMTPEQAMHPGSRNGWTPYLLFYQRKQKSIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L4</accession>
    <name>A0A0B1P6L4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5912</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01001155">
        <property type="protein sequence ID" value="KHJ33903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L4"/>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
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    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
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        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="219"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="426"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="503" mass="57094" checksum="2514630802D95726" modified="2015-03-04" version="1">MAISISKNEEQYLISAISDWSISNGLAIKSLMYPNQNVSTDSKNEVITPVPLTLSPSPFPRTCFEQALAVQRDYNHLYALISQDEDFLRGIVDEIRDLDDFITKLWGIHQKVKNEGYTQNLSLGLFRSDYMVSIDEEVHDQPRIKQVEFNTIAASFAALSSRICELHRFLAQDFYHYTKDYHSFSISDLPENKSIQGIVSGLRTAFNQYTKSSSKANRTCIIFLVQESERNIFDQRHLEYALKKSDPPIPVFRLPFSEILEHTKIKNTVNRELLYFLPTDPIVVFEVAVAYFRAAYDPLDYPNQSAWDARFQIERSYAIKCPSILTQLAGSKKVQQVLVTSPVLNTFFPADESRLSNLKDTFTDIYPLDDSPTGLKAQELALDTILCQNYVLKPQREGGGNNIYRSAIPIFLKSLPKSKWKCYILMKIIKTPQVQNIILRNGNTERGGVVVELGIYGSCLWNNATKKILLNEETGYLLRTKGDQSEEGGVSAGYGCLDSCYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L9</accession>
    <name>A0A0B1P6L9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome c oxidase assembly protein cox19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g3141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001961">
        <property type="protein sequence ID" value="KHJ32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L9"/>
    <dbReference type="HOGENOM" id="CLU_141947_3_1_1"/>
    <dbReference type="OMA" id="FHECDSE"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="112" mass="12620" checksum="E213A31BA8177F9B" modified="2015-03-04" version="1">MSTFGSPGGRQINVKPIPPERGSFPLDHDGECKDIMVHYLMCIKKKKGSNDLECRNIAKSYLGCRMDKNLMAKDEFENLGFKENTDESKSNMETKAESDSKGENSNKGKLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6S8</accession>
    <name>A0A0B1P6S8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g5724</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000896">
        <property type="protein sequence ID" value="KHJ34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6S8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6S8"/>
    <dbReference type="HOGENOM" id="CLU_025461_2_1_1"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="159"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="320"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="461" mass="54043" checksum="4F2B174C02CCEF5C" modified="2015-03-04" version="1">MSYNHRMSMVASSQQQIRGKKKEEESDAFMRLPDKEIVGCISDIGVPFTVADLQMPNPLQIQMIFEWFAEILLNATRETVEPAMREAVEDVCGEYIDIIPPETRNLMGFYVSLRKLLIECGITDFSFQDLYKPTHDRLVKVFSYIINFVRFRESQTAVIDEHFNKAEVTKSRIENLIAENQEMELQLDELKHNRRSVEAHLAEKVKRNENIKRRLLDLRQGQERVSRRFENAKQKKNELTKALEEKTTEIILLRQESSRLKPYVLQSPAALQGSLTELSNTLTSVKVENDVLDRRARSLQTSTDTFSIVSSDVSSCIKQLEDIIIEISKEDEENKRLTKQRETLGDRRNSLKDIERTQNLLQRQLSKWTERTQKLRDGSEEKLLNAKIRMEELKQVHRNLTDERAEKGREIEKKRIHIEQTEKKMSDLKESIENEIHNAHDEFLKMDSHIKLYITELEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P782</accession>
    <name>A0A0B1P782_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative dna repair protein rhp26 rad26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6421</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001575">
        <property type="protein sequence ID" value="KHJ33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P782"/>
    <dbReference type="STRING" id="52586.A0A0B1P782"/>
    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
    <dbReference type="OMA" id="PTWTGQF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="409"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="736"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="920"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1169" mass="134066" checksum="6D4BEA14C44979CD" modified="2015-03-04" version="1">MSNDSRPTAQERTLGLPTSDHIKLASDQRDEIRNGFKQVQSSRETFNIDEAVVLESLTENVRNQDELERDITNRANLLMIEHEDELDSKRLEKIKINIEKLEAKKRTQKQRLNNTLNNSTVWDRCTREVENLNNEIRNLKKDITDIESRIEERHQYGREQNNYDSLGSNIRMPNESQKEYLIRTGKITPFFQTLGEEFENKYDDQAESSMNPKETVKPQNFEASEMKIRSHKNLPLPGFKHSSTYAEESGLRPRKKRRIQKLSEDPEDHFQSCPEEDNYSVESDQINSKSSEIDEYSESTSPISHKNEPICETITEDKVDLTGADDGNELTYQSRLKSWVKRRSAARKKTQLELSDAKDEESFNGEEEEEWFKPCPDISDHHFGSGLKLPGDIHPALFNYQKIGIQWLGELYSQQVGGIIGDEMGLGKTIQVISFLAGLHYSKKLTKPVIVITPATVLQQWVNEFHKWWPPMRVSILHSSGSGMMNLRLENKLDDRTKVYGASKKKSSAHVKRIVDKIIHKGHVLLTTYAGLQTYANILLDIEWGYAVLDEGHKIRNPNTAVTIYCKELKTPNRIIISGTPMQNNLVELWSLFDFIYPMRLGTLVSFRQTFETPIKQGGYANSTNLQIMTATKCAEELKTVISPYLLQRLKIDVASDLPKKTEQVLFVKLTKPQRDAYERFLASEEVSSIMNGTRQSLYGIDILKKICNHPDLIDPSLSTKSGYEWADPTKSGKMKIVEKLLQLWKGFNHKTLLFCQGVQMLDLLENFIKNIGCYNYLRMDGRTNIKLRQTLVDKFNKSPDIHVFLLTTKVGGLGVNLTGANRVLIFDPDWNPSTDIQARERAWRLGQKKEVTIYRLITAGTIEEKMYHRQIFKQFLTNKVLKDPQQRQTFQMKDLFDLFTLGDNDNDTTETGKMFKDTEVQFHSDTEKSKKGNSNKTSNECKNLNSEQEDSFTQVRNLTGVVGMENFHGYSDEERPISDEDRLMKGIFSGTDIQSALEHDQIINGKRVITADFGILEREAKKVASEAAAQLSKAAEVARNLTPGTVTWTGEFGSAGKIYHTSQGSSQRNISTYNNRRDILNGTESDPEFWRLGVKNLKGEDFKQLILSFIKKRGGSVLSQTLVNHFNRVCQTSKQTTEFKKMLDKVARLEFSQNNRARGKWHLKDEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P787</accession>
    <name>A0A0B1P787_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative splicing factor u2af subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001572">
        <property type="protein sequence ID" value="KHJ33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P787"/>
    <dbReference type="STRING" id="52586.A0A0B1P787"/>
    <dbReference type="HOGENOM" id="CLU_059852_1_0_1"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="24300" checksum="10F45A26BAAD303B" modified="2015-03-04" version="1">MANYLASIFGTEADKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILLPNLYQNPAYDPKVKMNASQLQNHFDAFYEDFWCEMCKFGEIEEVVVCDNNNDHLIGNVYARFKYEDSAQKACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKNPSPELDRELELSTKKWLRLRGRDERSASRSPSPEPTRKRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A5</accession>
    <name>A0A0B1P7A5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="JNVN01000805">
        <property type="protein sequence ID" value="KHJ34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A5"/>
    <dbReference type="STRING" id="52586.A0A0B1P7A5"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="CYFLYQM"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="355" mass="41162" checksum="138806B6B907BEA0" modified="2015-03-04" version="1">MSSRAPNPASGSRKISFNVSEQYDIQDVVGEGAYGVVCSALHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSFQTFTEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKIPFKQMFPKTSDLALDLLEKLLAFNPVKRITVDEALQHPYLEPYHDPEDEPTAQPIPEEFFNFDKNKDNLTKEQLKELIYQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Z7</accession>
    <name>A0A0B1P7Z7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001628">
        <property type="protein sequence ID" value="KHJ33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Z7"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Z7"/>
    <dbReference type="HOGENOM" id="CLU_054590_5_0_1"/>
    <dbReference type="OMA" id="GEHCTTD"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="232"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="329" mass="36563" checksum="C8EA257474374405" modified="2015-03-04" version="1">MSDSKIANLNDARDAHNLVEESLDPPELGHQELHSAGLGEHCVVDRPSPSDQRRLGKIRKLGDVDVYISRPSTDSSKPLKFLLFLTGATGLHSVNNQIQADNFAKQGFLVVLPDMFADDPLPGSATYEEAKDPSVIDAIKLRLAETAKSFLVDMWLARQTPQKVIPILMKVIEAAKDEFANEIANGDGIYSVGYCFGGRITLLLAGEKPDRFPTIPWIQQVQDEESSPVNTGPYIKAGAIFHATLVTKEDFRSIKSPLCFICVENDQLFPEDIKQYGEQSLKYDRIDCEFKTYTDVPHGFGVVGEYENARIKAAQADAFDHALSWLQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Z8</accession>
    <name>A0A0B1P7Z8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gtpase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000911">
        <property type="protein sequence ID" value="KHJ34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P7Z8"/>
    <dbReference type="HOGENOM" id="CLU_003828_0_0_1"/>
    <dbReference type="OMA" id="ATRFLMN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1594" mass="181030" checksum="7C607907E2E98030" modified="2015-03-04" version="1">MSPNARDATPESKSSSGLVNVFKSLTGIRPLKKQNSRSLLPPHQNDVKGYGLRNKNDQDPPNYNLLLEQLKAGNPLADRVAAAESLRFAIQQHPVNGLSFILKGAKDLIDPVNSKKARTTGFELLIACIQNTSLSDPERLAYFRILTSQSKEEDFHWKLAAIIRLTRNGRDLTGFHYEILPVLTAWLRQTWVTTSSHRKHECGIASLSQETDLALLFELIYDIVKFNFNISNEQDIGNIIEALLSILIRTQTSDDIRSCINVFDAIVTYGDVPNSKLMSCVKVLCSVYFNSDVGVQQEVWKTISNIYISHNGGNAIRIIFKLIREPYLGTKQALYEIRGALMILEKLFLKNGKSCYPLVPFSILIKSLERLSIVDNVIIKNDILRLILSLLSNEGKDISKNVMEEEWNLMFDVIRKCAYQILESPRCLTIEHNSETKCSVCNNYENNFVSLAENLQNLIARIESLLLQHSKNTDFFQWLDCVKFLVSFHQHLPETCARLVIDIFIEYRFCYPSDLDWKENLTLLLRSFFHNRKNSTQTRLYALKAGSDVFYALEAVNENINTEITPLFVNLILKDVRDEEDILVLQEVMSLITTVACATCDNEYFFYIIDNIRERILSDHPRFQIFSSTIKKNISSVRKSLFCEEYNALNQTPSNVITVAFIQMFILCMDKSVRKAQRLFQEILWILGSEDCEVDARVSALRLLCRLRADWANRIFLIPFTASDSLAAILYRTPDSLSRKQTDDAATFRLSRADEKVLPSPGARSASIGKGHTLSKKAKRISCGNPRTGQNNFPLWMEPDHEYFSHLTSSNVSTILVSFLNFEDKEAKETRDTSLTKSQKTTTGEIMSNQNNDKEDQPSLLDIAKYIKLVTRLIQKDCDWEIFSYIIVHLHSQLMNQALFMAAIPQIKNLREVLCDQIKTNKIQEPPIISGLRKSDILLCLFQILNALMSYHKHFSKSEEDEIVRIFVHGVGEKTSKCCIHALSICCHELPGSTSKMLVSILTKFSQIITQSHVAIHILEFLACLARLPKLYVNFREEEYRIVFAICFRYLQYVRDQKNKEIPIRNSIGCGKSVAGTLLGATDTISMESNPHPTTSDDLPEYVYALAHHVIIFWFLSLKLADRPAQVRWIIKNLISKDINGVETIDEQAQVTIDFMQRVTYADVDQSGPDPSFKKDVFGEINRKRWVIGDSLLTVEQATRKDWAQITKHQPSGTSSYLIQEKIRHPPAHQTQISTDAMKDTRHSDENIKLPSHLLLQLCASTPMSGESLRPIPLSECKSIDRAVSNLNRTFTVDSHKVGVIYIGENQTKEAEILSNIQGSSDYTKFLFGLGTLTKLRGANFNTQGLDRQTDSDGEYTFCWRDRVTEIVFHVSTQMPTDLENDPQCSNKKKHIGNDFVNIIFNNSGLPFGFNTFPSAFNFVNIVISPETKLTFVAQRLKPDMDDAIYKVQVMSKPGFPEISPAAETKILSLSTLPDFIRLVSLNASVFSLAWAHRAGGEHFSPWRSRLREIRKIREASGHKSSGISPPSTSHIISADSRNVRDSINSLRRSSINFFSQTNVPLSHRSSDQTSETEIKSIYGKDILLESLDFSKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C7</accession>
    <name>A0A0B1P8C7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nuclear distribution protein ro10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000609">
        <property type="protein sequence ID" value="KHJ34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8C7"/>
    <dbReference type="HOGENOM" id="CLU_091042_1_0_1"/>
    <dbReference type="OMA" id="WYEVGLV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="208" mass="23756" checksum="71FF73DCAB44D3DB" modified="2015-03-04" version="1">MANSFDNTALETINLLQGRLERIEYALCGDTDITFNTSSQTSIGERILVIEQKLKQLISEFKPLEELLNLYSTHQDLFNILWADSVPTDLDIISMKSIINASAILFSETTSRLNSVNDIPIPPPELSAQLIALQPQISKIEAIQANQLLEIKNLRERSALLVEKWYLTNVLESGEMWASLDRRARQIEQKIRQIRHAKQRDGVRQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8K6</accession>
    <name>A0A0B1P8K6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001549">
        <property type="protein sequence ID" value="KHJ33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8K6"/>
    <dbReference type="HOGENOM" id="CLU_131085_0_0_1"/>
    <dbReference type="OMA" id="HYCATNQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="87" mass="9855" checksum="24F13A58227B3A4B" modified="2015-03-04" version="1">MVNLGQSSVSGKWRRELEERCREAHISPPVFHIMSDRRGGRTAWSSTVTVQGQTIAARFWYDGQYLSNAIEDAAEHALDYLDLKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R6</accession>
    <name>A0A0B1P8R6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60s ribosomal protein l6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000528">
        <property type="protein sequence ID" value="KHJ35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R6"/>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="OMA" id="SSTHCIF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="227" mass="25099" checksum="E964E01C88422E28" modified="2015-03-04" version="1">MRMTKASLRNFVISGQKFLNVNDSLILNSTNGRFRPTLVSSTHCIFHFYSFFSTSSTRTSYVGRAPISVPPEVKFVLIPPTKNAQSTASHEAAHAKAEIEGPLGTMRAYLNNYILGVSEGHTAILRLVGVGYRATIETTATTVTPEFQGQQFVSLKVGYSHPIELPVPRNVKASVPQPTRILLQGPDKEIVSQLAAKIRMWRKPEPYKGKGIFVNGETIKLKSKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T0</accession>
    <name>A0A0B1P8T0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001507">
        <property type="protein sequence ID" value="KHJ33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T0"/>
    <dbReference type="STRING" id="52586.A0A0B1P8T0"/>
    <dbReference type="HOGENOM" id="CLU_2028442_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13891" checksum="F46BE5AB9E090EB2" modified="2015-03-04" version="1">MDVLYGVGRDRDCFIYCPLYPPTNTVYLTHNKPLPNFAYSRQKELDGLILRGVFEFVDIRAIPPGVRILKSRFVDCLDTNIDTLRLAGTPHAFEKSHLVIQGYNDSDKSEVLTQSPTIQWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8V7</accession>
    <name>A0A0B1P8V7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery associated TMA7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000754">
        <property type="protein sequence ID" value="KHJ34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8V7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8V7"/>
    <dbReference type="HOGENOM" id="CLU_184661_0_1_1"/>
    <dbReference type="OMA" id="KKGPMNT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7197" checksum="C07B1F4823C27012" modified="2015-03-04" version="1">MGGVDRAGGKAKPLKAPKKAAKGEMDEEDKAFQLKQKADAKAKAEMAAKAKSGKGPLNTGSQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Y3</accession>
    <name>A0A0B1P8Y3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000498">
        <property type="protein sequence ID" value="KHJ35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Y3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Y3"/>
    <dbReference type="HOGENOM" id="CLU_096188_0_1_1"/>
    <dbReference type="OMA" id="GTMHQWV"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="22584" checksum="474889C5001843EB" modified="2015-03-04" version="1">MANTLPRSIETKILPKDNGLPPIHRHITTHSKKGTAIFDGNIPSNAKWQHIGPNPEEAPMASFFLAYTTSGFPVDVNPPKDGRSSQPLDIEQYKQKLSNPPNDLSYGDASILRYVDFAPATPPYMHRTQSIDYGIVIEGEIELILDSGEKRRLRRGDSCVQRATMHAWRNTSDTEWARMVFVLISSTLPVIGGNQLGTEMPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P967</accession>
    <name>A0A0B1P967_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative 26s proteasome regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001568">
        <property type="protein sequence ID" value="KHJ33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P967"/>
    <dbReference type="STRING" id="52586.A0A0B1P967"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="HOGENOM" id="CLU_052991_0_0_1"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902906">
        <property type="term" value="P:proteasome storage granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="334" mass="37377" checksum="AE4C6381CF85C831" modified="2015-03-04" version="1">MDRLNRMLASAGNIGGLNTTAPGSDNTMLIDNSETVYISSLALLKMLRHGRAGVPMEVMGLMLGEFIDDFTVRVVDVFAMPQSGTGVSVEAVDPVFQTNMMDMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEHLTPRAVAVVVDPIQSVKGKVVIDAFRLINPQSLMLGQEPRQSTSNLGHLNKPSLQSLIHGLNRHYYSIAINYRKTALEENMLMNLHKHVWTEGLQMEDFRTESARNRDRLKKLVGLAEGYEKRVREEMELSKEQLKTRYVGKMDPKKHLEEVGKQLIEDCIVSVSRQMIDKEASALKNSSISEDTATKNSQSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9K3</accession>
    <name>A0A0B1P9K3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001517">
        <property type="protein sequence ID" value="KHJ33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9K3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9K3"/>
    <dbReference type="HOGENOM" id="CLU_105624_0_0_1"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="14237" checksum="DF2FD23C73B2F3AC" modified="2015-03-04" version="1">MAPTKSSKGRQAKVTRKFIINASQPVSDKILDVSAFEKFLQEKIKVDGRVGNLGDIVQISQIGDGKIEVIAHTQFSGRYLKYLSKKFLKKQQLRDWLRVVSTAKGVYELRFFNVQNDAEDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9N9</accession>
    <name>A0A0B1P9N9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001293">
        <property type="protein sequence ID" value="KHJ33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9N9"/>
    <dbReference type="HOGENOM" id="CLU_026242_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="474" mass="53110" checksum="1F53771AE3D6B3C8" modified="2015-03-04" version="1">MTYPITSANRVSLPIHVSDRQPKLSGAQTKAYQTPCKDSSAFSRSSPVLAKSTTSIMNPLSVDERSVKEDGTRKRNLSEFTDSPSTLTDETIEERRWIPPSQRAPANIWCQFNWGPEILSPKITRFDSSNEYGDISYRKRLDDMSLPRSKVDACDSIEDIGNEFYSSGRNHDSSYKEKGWSQAAFEAINVVAGKAWEFCKNSTAIFRGFHAGGGTRYKLKYNEDSELYFEAFENIIPEKKENFYNPSSSHLSGGCSQTPQPISSNCSDEIKLDSSSHRPSKRYQLSRNNNDSLERNWVVVPTMSSTPNKTFHGLSAKRKVLSTGLPRYAPSHTRTPSSYTASRSTGGSSTYRRPSLRTVRPLVSHAGSPNLSSTQCASFASPRSPGGYIPRLATPNKKIIQNKTQEVFLGSPTTLESKRQAQKLATMLKKGVKRQDESIQRLDERLKEMIRQGKEALGSKFEVSMEDYEENEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9T7</accession>
    <name>A0A0B1P9T7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001454">
        <property type="protein sequence ID" value="KHJ33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9T7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9T7"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="55545" checksum="47C69F270F30A510" modified="2015-03-04" version="1">MIDTMPEIENASLPKELADITAIRQRLERAWRARLQTCTTMISNIDSILANFKEEVEIEEIVAFKTILRQAIANFAAEDSSSSPPLIPSHTQLSKGNGYSNHKDKDMNLKKVLVATPYIVPTPVLNRKKTQETALPKNPPTKNNTWVTVARNGHKKARVVRQSPTNKTATSGADKRLFVRVPREHEWRKLSPAGIREVLVRKLSISPTLIGRIKPVHSGFALSPCSVEAREAILNAGNGLFLTGEKLESATNWVPVIIPTVPSTIRKEQGDVEVSSSMLADEIEPPHRTWMSFFSKAPRAGFQVFDESGIARPFKKQQPIEFCKRCNGHHPTKNCSREPSCGNYVSPNHLVDICMATTKCRNCGGPHRSDSLRCLARPTRLGTPTKEQMKTYRQAGEREFQAVLRARAAEEIAATTENSNIEISSSLCSEVNTNFENPKASPVDQSTGDAPHDPTAVQPLLNWTPSEKTVAIGDFNSVYWAWQPSASSFYGQGEEIQRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA09</accession>
    <name>A0A0B1PA09_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001398">
        <property type="protein sequence ID" value="KHJ33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA09"/>
    <dbReference type="STRING" id="52586.A0A0B1PA09"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="303" mass="33499" checksum="5E8D4F13DEEDD31E" modified="2015-03-04" version="1">MPVTDRRLFVRLSQEHEWRKLSPAGIREVIVNKLAISPALFGKIKPINSGFALSPCSTEARETMLNAGNGLSLSGAKLEPATDWTPVIVPTVPANIRKEHGEVEVNKSMLIEEIERVCHTRPAHVKLYGGIKPGAPYRTWMAYFPIAPRTSFRVFDESGIARKFKKQQPLEFCKRCNGHHPTKNCSRALSCGNCGSTNHSEELCMAATKCRNCGGPHRSDSRRCFARPTRSGAPTKEQLKTYRQAGEREYQPVLRAKAAEELAASTNTNNTELASNQASEVDNEIDNIPASSVDLPTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA31</accession>
    <name>A0A0B1PA31_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative gnat family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000522">
        <property type="protein sequence ID" value="KHJ35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA31"/>
    <dbReference type="STRING" id="52586.A0A0B1PA31"/>
    <dbReference type="HOGENOM" id="CLU_101840_0_0_1"/>
    <dbReference type="OMA" id="DSHHERW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="26612" checksum="B2E8A5C6E1845491" modified="2015-03-04" version="1">MDFATLREGFSIGVATKEDRNEIWNIFLEAFGSDELWKCLTKNVVDSKELFPWLIAHMAPRYETPDTIVFKITENVTGKIVAWGAIQVPWKFLETEQAEILRAKAATFNPPPTIDGMNPEILKQVEKSVYAARLFGYDPENDYHRRGSMIRPGYQKMGFGTYIMHFCNQICDAKGERQWARSRPSSLSLFKKLGFVEKGNLDTNLKRWGGNKDKSGIPILVRVPKSDKQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA76</accession>
    <name>A0A0B1PA76_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001207">
        <property type="protein sequence ID" value="KHJ33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA76"/>
    <dbReference type="STRING" id="52586.A0A0B1PA76"/>
    <dbReference type="HOGENOM" id="CLU_025946_0_0_1"/>
    <dbReference type="OMA" id="VTNLHML"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="439" mass="48332" checksum="8A6982CD05F5851C" modified="2015-03-04" version="1">MVVENFIAATGSSQLLQSSKSAPSKSAGIFIYELQPDSKLKLALKNSSTPVNALTTTSTHIFAAQAEKAVVHVYSREKQNQEASIFFPYHVHSLAIVGDGILVLGTAEGRLVTWELSTGRQVSTVAAHLQPVNCVATTNSHIISGSEDSKLYVWLISHVLSLSQRDSREPLRCLSNHQAPITSLTVGHSRSTTNICVSASKDNTILVWNYHSGQLLRTFLLSRAPLCLTLDPCDRGVYVGLDNGSIQMIEFFQPNSNMHPLHVTELQAIPVKVSTPEWSVPGDVGSILCVKSNYDGTLLLTGHSSGQINQWDVGRRQYSSEISNLTTPVTNIYIESPFPSTQKTKIITVTKPKLTDHNYTLNTQLIGSVSSEFDEAVLAEGIPIDMIKEAVAKYTTPSEFSSEANQKLRKENDDLWKIIHEQRAVQKMMLEKYTPLQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAF7</accession>
    <name>A0A0B1PAF7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000470">
        <property type="protein sequence ID" value="KHJ35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAF7"/>
    <dbReference type="HOGENOM" id="CLU_1688037_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17446" checksum="B8A3BAC443632351" modified="2015-03-04" version="1">MVCFRSLDISLIDIHIIELVSLLLLRSTLKEPIPSFNNEAISRLQDIENKQRTYSEAASKVKPSNIASQRQTPIFRQNLTTTQGGDAMDLSANQLRPQGPISPEEKERRRINGLCYYCGRGKHKASECKIKNSFSSAQGFAVDTVVNNYSGKEEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAN0</accession>
    <name>A0A0B1PAN0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative gap2 amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000895">
        <property type="protein sequence ID" value="KHJ34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAN0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAN0"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="83"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="333"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="626" mass="67949" checksum="D69B1AE8096ABC00" modified="2015-03-04" version="1">MSFTSPNLEKISTTPSSDPYSEVESPKCKQHIFWNIVDSFKRDPYLESNVLFYTTSQSSGFNHAAAARKTANSGLAHQLKSRHMQMIAIGGCIGTGIFVTSGATLSTGGPASVVIAYFIMSILIFCTIQALGEMAALYPVAGSFSAYSTRFLDPAWGFAMGWNYAIQWLLILPLEIVAASITLSYWPSMEKLQGAFGVSIFLSVVIIINLCSVRGYGEAEFIFAIIKVVAVVSFIVLGIILNCGGGPDGEYIGGRYWVTNNVPPNYLGYLLGQKPGSIASGAFRAGFKGVCSVLVVAAFSFTGTELVGLAAAEAGESLNLSTLSDKAKKFLLENPRKSLPTAIKQVFWRICIFYICSLTVVSLLVPYGDSRLLGNSADAKASPFVIAITNAGIEILPSLMNFVILIAVLSVGNSAVYGSSRTLAALAHQGQAPRFLSYIDRRGRPIIAICVSSTVGSLSFLVAGGPDMAGIALKWLYSVSGLSSILTWGSICLAHIRYRAAWKAQGRSTKELTIRSQVGIVGSWIGLFLNFSVLVAQFWIALWPIGFGTRPKYEIMKGFLQAYSTVPFVLIFYISYKVYYKTSFMKVSNMDLDTGRRDLGTNGINQCLCENLETLPRWKRVMKVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAW7</accession>
    <name>A0A0B1PAW7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001042">
        <property type="protein sequence ID" value="KHJ34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAW7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAW7"/>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OMA" id="VEITRCV"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="31914" checksum="688C8329CCE2FEE4" modified="2015-03-04" version="1">MAKTFATTTTCLKAEGKLRTYKPKEEVWFDDGREEKLLEYVKAKLDPESLNRSQDIIQLIDDFGVNENFMMNVGERKGSCVVDLIERHKPAIMMELGSYVGYSTVLFASVLKKIGGSSYISFEREPKFASVAAAMVDLAGLSDIVRFVVGPSSSSLVSEHAAGRLNSVDIVFFDHYKPSYVIDLKILESLNIIHEGTVLIADNVIDPGNPSYLSYVRSSPDQKSASINAASIDLNAFPSDSVHQYKKDYAPDKTELPGNPNILYESRLVLSQEPTGSPDGLEISICKSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB40</accession>
    <name>A0A0B1PB40_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001187">
        <property type="protein sequence ID" value="KHJ33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB40"/>
    <dbReference type="STRING" id="52586.A0A0B1PB40"/>
    <dbReference type="HOGENOM" id="CLU_465376_0_0_1"/>
    <dbReference type="OMA" id="NTRENYD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="552" mass="63938" checksum="3E1E28A795CE82D7" modified="2015-03-04" version="1">MFRPNSQAIHRLELGHGRVSNLLRKSYRHFSSGGQEPPSQSSKSTISDNESKEPDISLKSEKLNERPLIRRTAIARGVERPQFSTFRFNPDLGSFDRKSIDNEYFKSKSTRFSDYNHFDYTEDPLKEIRNEQDESIETRDKSMDDSVLLDEASYEQSSTITPLEKRAFQKIFKDIFEKKQSREMLDVFGEPFLPTENNDQVGAQTCQKEVDEKIDDIISKSYVDIPEKVKEAYSKLEQYPPVLRASAAEALGYDKLISGENIEMKSQNSDFYDTQKKESLELFGDPVALKEKVRKRELEKRIEAIREAERERVEAKMRAATVDFELWKILDDEVFCLIKKLGLEDLPKSKESLSSTMNTGKPEFYGSFKTPTSYISQLPVLQKTEKSPDDLATKHNISPLQLYGLLYPYYLLLALRLLDRSFSRPSPLALALLPKIKSLGYISRVLGANIQFYNELLLIYRFRQNDFNGMLRLLEEMEMSSLEMNHETLDIVVQLSRVQDRVRQGSQGLGMSFLWSLPNFARGKFGPWRDYIKEILETRQRSPKIVLSRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB47</accession>
    <name>A0A0B1PB47_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001002">
        <property type="protein sequence ID" value="KHJ34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB47"/>
    <dbReference type="HOGENOM" id="CLU_424012_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="646" mass="73236" checksum="79D24BFA7845CE05" modified="2015-03-04" version="1">MINLFESTYRRTGIIQVVALWERLSGLKYTGSCPVKFVTKFKTEARNYQAAGGQSSSTHLMILFKQAVKDKARKWHNMVSSLSRFHEWKLEQLLQDSISSNFERIGRSDGLTKNSQADIRRVLSNTQIEKDKSPKKKQHGKGDAGKGRGKRIRCWRCKSEGHFANKCPKRNTKSSINNTNSGHVAPPAGLTNEYCVVSEDETSSINYSAKVLPQNFEDLVDLYDREMARRSVDTASQELPEIESPVGSINIAQQILSTSSLSSTTDKWLFDTGADIDATNRRINLVPEKIVDLRPKQFPVQTGSGIVFAECVGEVLLPLKGIKSERTVIRLKYVVCLKSLPLNIISGERFYRRGGYIDRNRIVNPEGRTITHIDTERRRFFLWLHGRPEPLKSVGPHKPVTHHMSSKLEVFKKSKSTTNNAEDQEFKVAYNACYTNGIFKMSDDVTRRLIHWHRRLCHPSADRLKWTIKDTIDIDLDPSDVKSLPCEACDMGKSVKFTTSSRRQRMENVGEEWHCDVGSLSPMSLEGYEYFCLTKEDVSRYRIFRALKKSEAAEELKTILSRANSELRLRHNLRPAKSKSPPSRGAGVNAQYALHVWNSQEDSQNPSLQDLPFITAGLNCLHFYITFPSAPFFTKPPTIGPGSIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB90</accession>
    <name>A0A0B1PB90_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g2795</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="JNVN01000789">
        <property type="protein sequence ID" value="KHJ34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB90"/>
    <dbReference type="STRING" id="52586.A0A0B1PB90"/>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="OMA" id="CFENRGA"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="208"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="380" mass="43944" checksum="5BC8830AA0786317" modified="2015-03-04" version="1">MSEEILNDISHRRYNPLRGSWLLVSPHRTKRPWQGQQEAPSVNLLPDYDSLCYLCPGNKRAQGDINPNYTGTFLFVNDYSAVKEKQAEYKMISDLRDSSSQLLRAESVTGKCIVLAFSPFHNKTLADLTSEQILPIVHEWTQIYIRHLDPTSPLAQCKLQDHKNCTVQYRWMQIFENKGAAMGCSNPHPHGQIWITSTLPEEPALELAQLKRYRVENKGRNMLVDYVDLEVKKGERVIFQNDSFLVLCPWWATWPFEVMIIAKQHKRALVDLNNIEKLEFAEAIAEVTRRYDNLFETSFPYSSGIHQAPLTGTEEDMACSHLHMHFYPPLLRSSTVKKFLVGYELMAEPQRDITPEQAAKRLRDDCGGELYRKKIEMKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBL4</accession>
    <name>A0A0B1PBL4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000737">
        <property type="protein sequence ID" value="KHJ34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBL4"/>
    <dbReference type="HOGENOM" id="CLU_117724_1_0_1"/>
    <dbReference type="OMA" id="AMFVLDN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="119" mass="13537" checksum="A290A359AED3DCD1" modified="2015-03-04" version="1">MNDSDSSSSSLSRSIMQDRQARDKDPFYSSSSYSESSDENDEKSTSSPIRKESYQTLQTRREAAVILDNPELLFMYSNARNDSLAGTRHHFTKILCGYADKEEESNKKQKSSRVPIPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBR4</accession>
    <name>A0A0B1PBR4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fibronectin type iii domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000128">
        <property type="protein sequence ID" value="KHJ36142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBR4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBR4"/>
    <dbReference type="HOGENOM" id="CLU_005801_0_0_1"/>
    <dbReference type="OMA" id="LQHENEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="870" mass="97431" checksum="9B6C64B7D4B30AD2" modified="2015-03-04" version="1">MFIIQFVATCIALIWLLFRAWQTLWKPVPELISILGVEVPDPPEVTLSGITSDSVTLHWSKSDSQKPASKYLIQVNGLNVGETSWLETAITVTGLRPVHYYNIRVISVGSNNFQAGSLVIRVRTYGKDGRPALDSSFSPPNPAPEDEVTDSGNETSDDGHGVCVEATALPDSFTNTHQDYNSFNSTARNSGQIKNSGGKGSGRRQSLSTESAESIPSSTQKLWVSKESVHQLTLQLESMNRDRDKIAREMAKEIKDLKDQYANICSDRDKKKLILKEKEKASEKLKKEVNHAERLNRQAQMRKSQKEKILKEKLAERLKMKDDMKRWKREIEEMKVERGLWREEREKAEKNDQINVTELKQEIKKCQTSLNIIEEEIRLKGSQIKKLEKNRKRLSTCENGKELRLRDEHEDREWDSTEKALSAKLNTKSQQLRELASCLHQQQTYLATLQNKSPTIYQGYYSSFDYDSSDTQLGVKPRNNLNRGCQSMPSSSFIVPGTFGCQSPVFAPGPYIDMRNDSVNDPQLELTDHMTEEDYILLTAGAPLSPTASSLLPSNIFSDDDSPIHISELEDSSLPAPTNIYKNLKSSQTNCKTSNSPNLSTSPLQSSKQNPVYCAPSREHTGNDRSLPSHRLSHSVIMPQKPPKNLNNKGFRNLFLPKLKSKDVCQDGSISESMSPNHSNVFPQFLDEELSTNGIKHRRISFPSGWASFLHKNSPVKEISTESDSSITYTPKSNIQRPNLGLAGSSTDDLELQDAQSSSPYARSVVSFDLPRPSTDSAPFGWGPAQDNITNRNSPLSTDWSHYSSNHNSIKSQTSWPNNFSKRTSFKYGLNTAFLSRLANDDDDFLPPSEVMTSQSSQPSAIGTIGVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBS9</accession>
    <name>A0A0B1PBS9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane associated chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001042">
        <property type="protein sequence ID" value="KHJ34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBS9"/>
    <dbReference type="STRING" id="52586.A0A0B1PBS9"/>
    <dbReference type="HOGENOM" id="CLU_043818_0_0_1"/>
    <dbReference type="OMA" id="FSAWGRY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="356" mass="41454" checksum="CDEECA3134DD1F52" modified="2015-03-04" version="1">MNNQIISLIGWRFLPDLITGWVQNICYSLIIGAGKSKPLPGSTKYIRDRRRIYIAVVTVYLLFTIYEADWEIRQEPNFFQILNLPETANEREIKTRFRRLAAVHHPDKVTNNSPSVEAYFVKLRLAQDTLLSPVKRFAYERFGPAILEWEHCSSKRDYLLQGFYRSLPVYLGSAFVMCFFGLLGYVTIGNFWRWLAFICLGVFEFHMISRPHIPQILSKFINPIITSFTRHPPFLPFQFIQLAHRISVTMYIALSQLGPFFQPNIPEEPSYLELSKNLVSLEMKVKSIEVEASRLLNLNLTPFFQEKNGLHDLQEKMKEWLVQNTIRMDPEVRDAASISLEKKNSKVVTVTKNQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBW8</accession>
    <name>A0A0B1PBW8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000863">
        <property type="protein sequence ID" value="KHJ34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBW8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBW8"/>
    <dbReference type="HOGENOM" id="CLU_909715_0_0_1"/>
    <dbReference type="OMA" id="TINSYHE"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="306" mass="35720" checksum="FF539099EFE24D99" modified="2015-03-04" version="1">MVISNDERQKTNQNHKMASDTNGKSISASPSMNGQTRRLKPVKEKKKRKSIYRVGNLFRIAFWYFIFTCFYCPSSLNSLTNDSPKACKAYFQVTNFVAPVIQPYLNIYAAPYLEPIWPYYTAIQKRIIKPTLKLGGKYGVPLVEKVFLLIKFNWRKFAQPQVEKCYDTLYQYYRLKLGSYSDIANKTINSYHEKIKTELLPIYSSIILSYYYAIEPQIVKGYILGHEIVTNNIYPCIKWTLNNGESFFVGIIRPKLKLLYGESVEPQLLKISERLGRYRTARKIKFTSNENHRKVSLQSLKLNTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC51</accession>
    <name>A0A0B1PC51_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g6323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01000820">
        <property type="protein sequence ID" value="KHJ34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC51"/>
    <dbReference type="STRING" id="52586.A0A0B1PC51"/>
    <dbReference type="HOGENOM" id="CLU_068508_2_1_1"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="51"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="178" mass="18742" checksum="5E5E9F83977ACBA3" modified="2015-03-04" version="1">MSSTPLPSDSIAHQVKRSRLDSSSTIEAAPSGTFSTTMEIPLLVKKLSARARLPTRGSAFAAGYDLYAAREISVPSRGKALVATDLALAVPPGTYGRIAPRSGLASKHMIDTGAGVIDADYRGEVKVLLFNHGEIDFAIKEGDRIAQLVLEKISTPEVKEVEALEDSARGSNGFGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC83</accession>
    <name>A0A0B1PC83_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01000814">
        <property type="protein sequence ID" value="KHJ34576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC83"/>
    <dbReference type="SMR" id="A0A0B1PC83"/>
    <dbReference type="STRING" id="52586.A0A0B1PC83"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="129"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="446" mass="50108" checksum="E1794A4C619D18AC" modified="2015-03-04" version="1">MDNNMSSDPKEAEEYFKVKESETLKASEIDRNETSNGPKDDSEIEDERETGDKVSGTSITKKRKKKKSKKSRANATKQSDPPRVLLSNLFTNGEYPVGQLEDYRDENLYRTTDEEKRNLDRMENDYLNEYRQGAEIHRQVRQWAQKNIKPGQSLIEIAEGIEDGVRALSGHPGLEEGDNILGGVAFPTGLNLDHIAAHYSPNFGNKTILSKDNVMKVDFGVHINGRIVDSAFTMSFDPTYDNLLEAVKQATNTGIKEAGIDARLGEIGAAIQETMESYECTINGKTHPIKCIRNLHGHDIRRWQIHGGKSVPIVKSNDQTKMEEGEVFAIETFGSTGNGYVRDDYETSHYAKMIDAPKNVALRILSANKLLNVINKNFGTLPFCRRYLDRLGQEKYLLGLNTLVSNGIVEAYPPLVDKKGSYTAQFEHTILLRPNVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCG4</accession>
    <name>A0A0B1PCG4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000945">
        <property type="protein sequence ID" value="KHJ34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="52586.A0A0B1PCG4"/>
    <dbReference type="HOGENOM" id="CLU_1595780_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="167" mass="18962" checksum="AF5144154E4ED960" modified="2015-03-04" version="1">MLALLKSIDDTIFPTDDEHCCTVINFILNRTQRQRNVLDASDLAKDKTSQRHDLGIKANYQFNPGNMVMLYDHKESGKKLRATWRGPFIITGYGGDMHRSYTLRQISGKPISCHYHGDSLKPFRLREGYIVTNEEAGLPISQNIRLGRAAFKLPREQRTVAGSLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ8</accession>
    <name>A0A0B1PCJ8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative gata-type sexual development transcription factor</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">EV44_g2708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
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            <authorList>
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                <person name="Riaz S."/>
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                <person name="Amrine K.C."/>
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                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000172">
        <property type="protein sequence ID" value="KHJ35983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="IRSIINW"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052138">
        <property type="entry name" value="GATA_ZnFinger_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255:SF4">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="185"/>
        </location>
    </feature>
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            <end position="271"/>
        </location>
    </feature>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <end position="216"/>
        </location>
    </feature>
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        <location>
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            <end position="228"/>
        </location>
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        <location>
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        </location>
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            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="55831" checksum="FC1DA0E4F15CB17C" modified="2015-03-04" version="1">MPWSPAFPDPNILPAMETVNDSQRQSGIRSIINWDLYDGNCDFPYHPNKMAAAVAVNSSYPYPSDASSRYEVASSAFSGRSSSLHSLISNTDSRWPPKIHNNSIQTQASQTRLSLPSIHEALGSKPTYETSVPHSLPPSHDGEYAPTKTPTIPRTYPLSEQSQFPSSGQQPSSQHPHPPRHSFSRSLEQMNPLFSEAVTHPTVPAPTSQSSYNSRLDGNRYEREHQTSERPLSGHSHHSVNHSTFDSARTSSMPPSNQVTSTFTQSEVPPREYQDPFEIWRKSRDNDKPDIACKLRGGIKRNLDVWDFENNLAEINMASSALKEWSAHYNSIAQDRQLSSCALTERMPSIESLKEIRQYQQKIYICLEQLTRIVSEADQQKLRTTVEQRPIEKNSQARDYDEDVTMNHVEEPKSIGLTTEAKKRRGRAAPPGRCHSCNRAETPEWRRGPDGARTLCNACGLHYAKLTRKNTTNKLAQNFSNPSTRPKSSEIPPRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCN1</accession>
    <name>A0A0B1PCN1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gelsolin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCN1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCN1"/>
    <dbReference type="HOGENOM" id="CLU_302086_0_0_1"/>
    <dbReference type="OMA" id="WISHESP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="2">
        <location>
            <begin position="8"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="858" mass="94618" checksum="9ACBFAD7024593AF" modified="2015-03-04" version="1">MSSTVCESEDVHDFLERIKEIGKLRNREDEERNRKLEEDIIQSRMERQARRAERARSISPTKSSPVNIPFRNRYSVPRDLLFSDIPPLCATGGGELQQKMALDGETTSVRRNSSSPVGTENDTTAHDTGEILEQSSTSNLNSNIASSKSPTQFWHRRPSVQAPSLHTSAQTLKITTEDATHFQNIPLLSSPGHETSSLPSRDQVLQIPASTCSSNSKQENSLESRSSFLENLEFIRNKSPECELNCAAKFSDMTRTESPLKLERRNLFKDRLLSHSRNLSESELLKSYQASSSLSEKNGLRVSSIAPQKVQGRGETEIVSQKSIVSPGLGYRSLDRSNRSSSPTKGTGGFVQSAMMRRNDSVSKRWSASSSPNIVKYESVKNSIVTGAGYKSGLSSTGSYTNFDTRPHSSHSRFSITQESIGTSNSLRTNTPTPSTKSSLENSPILVPHSENASWISHESPNHSTPKNEETTPPNSPTKTLERRRWSPTKSSWLEAALNKPDFVKLKPKTTSPLQQPAWKSEIGKAKQKVQTEIGYSPNLAPKHEVNIGGLMRSRPTGSPPPATNLPLLNSRITSGVSKVSNKISAFDCQESSPIIKPLGNSTSPVSSTLRSAGNLEHSSKSDFRANLRSCNIQSSSVNSCGSELKNKFVQLRPTRTQKYVAPDEFKENITRGKASLNATAGPQKTNHKDEFKEAILKKKEDFRKAKLEGRGVSRSSNEIEKKSLPEALIKQRTLGRSNSIASVSLKYSDSLNSSEPKSNQCFSSSLHSHSASYSDEPQNRNHGKVINTINPNLAELLVQSLHQSDSQGLKPKIIQIPPNHEDLKSSESRELDTKLVFLTKNRARGPRRKPPSSVAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCV7</accession>
    <name>A0A0B1PCV7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000714">
        <property type="protein sequence ID" value="KHJ34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCV7"/>
    <dbReference type="HOGENOM" id="CLU_2160276_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="111" mass="12159" checksum="59BA962E1BD0F1D2" modified="2015-03-04" version="1">MAAADNDVDMLPPSTPLRASSYLPRSTSTPTQRSRILRLTDIMATQDASYQRNETPYSPGDSFTAFNRIPSIKTIGNISKATEKAFGKASENLTEREQIAEGYSKALDEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD08</accession>
    <name>A0A0B1PD08_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000819">
        <property type="protein sequence ID" value="KHJ34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD08"/>
    <dbReference type="STRING" id="52586.A0A0B1PD08"/>
    <dbReference type="HOGENOM" id="CLU_010365_5_0_1"/>
    <dbReference type="OMA" id="RRWWYEL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="13">
        <location>
            <begin position="120"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="14">
        <location>
            <begin position="287"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="15">
        <location>
            <begin position="372"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="560" mass="62702" checksum="06CFD4F2EF1D9C3E" modified="2015-03-04" version="1">MADASDAKLSQALMKKIRQRKNVEAASHFALGIMGIVCLYTLYFWAGPLYRRICIGSRIKTACHKPAEIMRMIRRKLIVDTPGFISWGHAVICILYVVVSLSVLFTNINWVNLSGFAKRLGWLTVLNMCLSIFLGLKHTPLSLLTDQSYEKLNCLHQVAGYSSIASLFLHTVVYLFSLNKMGKLSRVIMEKAQVMGILAGFSLLIIFLTAISLRKRHYEVFYVFHILMVLSAIILAGLHRQRVSVTRSTYILIFAGLIWALDRFLRLSKYVIYSYKNTATITPLPYKGTRVEFSKPLKSTSPGQHYFIWLPDIRTFETHPFTCISAENGEFIVAAQNGFTQSLYQRALKEPGVTLRASFDGPYGNPPDLTGFTKVLFIAGGSGASYTCSLAVDLVRKLGHSTKTSLDFTLVLRHKDMIEWVSTYLNILASSPIVSLQVHVTRKGSEESRNSLLPLSNFIGSFPLDTLYTLQNLPNVTEKVDKRDTLTSNIFVKAPMELNLGRPDISSLISQAVNISSTTERIAIVACGPNAMMVNVRRLVSENIRPEGPSLQLFSEQFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD77</accession>
    <name>A0A0B1PD77_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000786">
        <property type="protein sequence ID" value="KHJ34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD77"/>
    <dbReference type="STRING" id="52586.A0A0B1PD77"/>
    <dbReference type="HOGENOM" id="CLU_009854_0_2_1"/>
    <dbReference type="OMA" id="VKILCWD"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="34794" checksum="AA26E09E7752D282" modified="2015-03-04" version="1">MKIAILQFVPLKGNIKGSIAKVEKLIQNLRPGDVDLLALPELAFAGYNFPSLESIKPCLEHAQSGPTGIWAKQTAKRLQSIVTVGYAETTSKRVAINDNSLENIDRNMNFNSNIAFGSDGKMIAHYRKHFLYMIDESWCVEGSERFYAGNYPAPVNKRVAMGICMDINPYQFKAPWDAMEFANHVLDSGAELVILSMAWTNLDASAEEVSDSSINTQPDWQTIRYWMSRFHPVIQANKTVHIVFGNRCGVEHDVVFVGTSTIARVGCGKVEVWEIAGIGEERLLVVDTNTKPKIIWNFQADKFQTNDQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ0</accession>
    <name>A0A0B1PDJ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000568">
        <property type="protein sequence ID" value="KHJ35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ0"/>
    <dbReference type="HOGENOM" id="CLU_492744_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="456"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="553" mass="59289" checksum="ADAEAB9EAD3E92FA" modified="2015-03-04" version="1">MIPTFSSPIGSNNKGGDKKNGASQSFLSAIPTPPLPHIPKVPNVSQILDAAQVPEAISSVTSKIPEVTNATEVATEVVSTVTSLFSKNKNPTVPHVPNVLSSSISQIPQTSEESNSSKLVSSAASIFSSNKTEDGAHIQVPSLISSIASNLPKVPEVSNSSKLISAAASILTIDKKDEGIQTQVPDVISKVIPTVSEVPRVADLISTSTSVLNTCKTDDNTFSHVQDAISLVASHVPQTSELPSTSRVISSTVSLLSKNEKDESTNSLLPSNSQSELTKIPQISMVSQVSDLIQEPQKSEIAISAISGLRKEIKVPEVFSSVTSLTTQAPQLPNVGSSITSSLDAFNKNDNPQSLLSAIPQPQLSQISQVLPAHQVPQFPDLISSSTPLLGSSNIPIETIIPLLRQIFTQYLSSPTQQKAVVWLALLDFARSMVGIVINFLLNHSGGYLDGFSFIFDGIRSLLGMFGFMISNAFVVEQAISFWTFGLRNYLTSPYHILDLLVVGITFASSLLPSFIDEFASLLVILRLWRLFKRVGSIIPNLNPIRSLPNLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDU4</accession>
    <name>A0A0B1PDU4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sun domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000366">
        <property type="protein sequence ID" value="KHJ35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDU4"/>
    <dbReference type="STRING" id="52586.A0A0B1PDU4"/>
    <dbReference type="HOGENOM" id="CLU_026108_1_1_1"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059577" evidence="3">
        <location>
            <begin position="23"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="561" mass="60140" checksum="135AB640D18B0438" modified="2015-03-04" version="1">MRSYCVCISYVATLLLLQFCNSDAHVHKHHIRFAPTHRSHSHLKLIKLRQADLSVNETTDATPKSHFGLNKEVGKCEFPSNAGLTPITPHAKNAGWAMAPDEQCSPGSYCPYACPSGMVMAQWNPNAKAYTYPQSMDGGLYCDQYGQVKKPFPDKPYCVSGTGGVGAHNKVGKGVSFCQTVLPGGESMLIPTHVENLTDLAVPGTNYWCKTAAHYYINPPGVKVEEACVWGDETKPVGNWSPYVAGANTDESGQTFVKVGWNPIFTGSKLSSTPLQFGVKITCDGTGCNGIPCTIDPAVGGVGKVQSINKSTGAGGADFCVVTVPKGIKANIEVFPSGTSIKDVSEEMPSTSNKIESSSSSSSVAQSNAKPAATESKDLEETSNDSHITESSPVNNTPKIEAPSTISSSFNGQEKQSNLFSPLPLSDKEFDMQENNDSKPKTYPTQDSKYESTQTGKDWGASTTSSSEPGHLFDEPSTNLPQPKNDIPHSNTNHSSSKSTLFETESKFTSMASAGTEHMAAVTSHETIDSSQSVSMAPISKIFTYSSIMRLVLLISVFNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEE8</accession>
    <name>A0A0B1PEE8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative opt oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000295">
        <property type="protein sequence ID" value="KHJ35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEE8"/>
    <dbReference type="HOGENOM" id="CLU_004965_4_2_1"/>
    <dbReference type="OMA" id="MTFDWAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="893" mass="100349" checksum="6237C695935E52F5" modified="2015-03-04" version="1">MRKNNEYQDNLEQHKNSRGDSELVNNISAAAKSSGLTEAQKTAYIRNCHMHRSSKDGPSKKVIDGSKESMQVENTLPNNAVNPNHSLDTQPVILVNREASPISGVGNTHENDHFDSLTVIQNEDPYNNSLDSMVRASVPTADDTSLSVNTPRMWCLSLIFAALGSSANLVFSLRYPSVYITPVIALLLAHPLGLLWDRTLKYPDDPVDEFSYGFKVNNKGNMKGWKGLRHWLGQGRWNRKEHCCVYISSNVSFGFAFATDVIVEQTKFYNQEVGILYQLLLTLSSQILGYAFAGITRRLLVRPGAMVWPGTLMSVAMFSSLHKEENVVANGWKITRFKFFIIVWACSFGFYFLPGLLFPALSYFSVITWIWPKSAVVSSLFGVVSGLGIFPVTFDWAQIAYIGSPLLTPFWAALNVVGGLVIIIWIIAPIAYYLNFFNSSYLPILSSSVFDNTGKVYNVSKILTPDFILDRKAYEQYSRIYLPITYVLSYGLQFAALASLLTHTICWHGKDIWRIVNQVFGISTNDDNFRYQPLLACVANPTYSKTHVKIKSNVGSSIFDDDVHNRLMERYKDAPISWYLLILFSMSGVAIFVCEYYPVYLPWYGLLLAVGICAILYVPTGIIMAITNQQPSIYIICQLVCGKFFPGKPVANMIFVTYGYISSAQGIKFSGDLKLGHYMKIPPRVLFSIQLAATIVSSLTQISVLNWIFANVPKICSPDAPNGFTCPIAKVHFNGSILWGVVGPKEFFGVNATYRNLIWCFPIGATFPVIFWLYSRRHQKSIISKVNFPVFFGSLCWIPPATGFNFSVWALVCYVFNHIIKNRYSRWWAKYTMTLSAALDSGMAFGLVVIFFGFVFTGISEKWSWWGTTIYKQGCDWAACSYRTLPPGGHFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEL3</accession>
    <name>A0A0B1PEL3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative inositol phosphosphingolipids phospholipase c protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1033</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000432">
        <property type="protein sequence ID" value="KHJ35331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PEL3"/>
    <dbReference type="HOGENOM" id="CLU_034001_0_0_1"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072711">
        <property type="term" value="P:cellular response to hydroxyurea"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="488" mass="55522" checksum="D7F2D2D093F78037" modified="2015-03-04" version="1">MSSTPPEINIITLNCWGLKYIAKYRNQRLSEIGRRIAIAEPVPHIVGLQECWTHEDYQNIRKNTKHVLPYGKFYHSGIFGGGLAILSRWPIVESSMFRYPLNGRPTAFFRGDWYVGKGVACASIQYGENSSKDIIEVFNTHMHAPYEREPNDSYLCHRTAQAWEISKLFRGAAERGHLVVGLGDFNMVPQSLGHRLITTHSPVKDAWLSLYPNSSIGAADDPQEKARQMPMPSADYNIKENGITCDSILNTWRWTKDQQKLLGPDKPGISISLDKMDSKAKRLDYIFISSNPQSTTPEQDAFFIKSARVGMLFRHPTLQCSLSDHFSVEATIAYSKYNDSVPSKYEPNIMNGVYLQSPRSSIFRPSTKNSKKYLPIYIYDEVLDLIHKYRRREQQQRRARLLHFVASLILSAGSTIAIWWISQRYIIIILMIFNALNLSAGVIDGLIGGLFMGSEIRALKEFEWEISNAKAISCGESHSISQEDVKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEX6</accession>
    <name>A0A0B1PEX6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01000376">
        <property type="protein sequence ID" value="KHJ35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEX6"/>
    <dbReference type="STRING" id="52586.A0A0B1PEX6"/>
    <dbReference type="HOGENOM" id="CLU_024136_0_1_1"/>
    <dbReference type="OMA" id="GEFRFCK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="106"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="467" mass="53517" checksum="48B0E07152A70AE4" modified="2015-03-04" version="1">MYLKLARKCERCCCLGATYFPLFFVYSLTTWALWVVTTIGFLSAKTNWVGSGTSFLGIVLYLLLNWCYTTAVFTNPGTTTIKNEYSSIPSQVPSISSNLTVKANGGLRYCKKCQARKPDRAHHCSTCKVCVLKMDHHCPWLATCVGLRNYKAFLLFLFYTTLFCFLCFGVSGYWVWREIANEGQYTESLMPINYVILVVISGIIGLMLAGFTGWHILLASRGQTTIECLEKTRYLSSTRKSKLYFTNSFIEYSQNSDNIYAEANGNSQPMHELDSSRIHTGERVSYNEFEQARSRLRYQEYLDEQDSAKLPSAFDLGWKMNFFNLFGPNKLHWFIPVATTIQDGWNWEPNPKWLIARERIIQEREEQVEREQAAGWGSERPSQFSVNTQDSMRTESNNSRISLDNVSSDPFSRPISKADRVLGRTFEYSDNVILNNLRPRSSNDCRQAHDSIDPLENRAIDRKAVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF74</accession>
    <name>A0A0B1PF74_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ribosomal protein l19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000465">
        <property type="protein sequence ID" value="KHJ35239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF74"/>
    <dbReference type="STRING" id="52586.A0A0B1PF74"/>
    <dbReference type="HOGENOM" id="CLU_001127_0_0_1"/>
    <dbReference type="OMA" id="INEHFRH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="703"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1068" mass="120529" checksum="1630A4C7322CA0AB" modified="2015-03-04" version="1">MSSLRSTSDCFDSPPPLASKLSSPKREFIRNGTFILASTGERVRRQITFQENSKPGQLYYERVADDNSSSYNSPLLRGLNNLLPNKFQLTFENLQVKLCLFRGWLKTSIAKDILKCSLAYLLGSLGTFFPPLTRFLGHQDGKHIVATVMVFFHPARSAGSMAEAAVLGFASVAYATVLGLLSMAISVFFETQCDMIEIAYGLILIFFCGGGLGLVGWFKQNSNSPLVGVACSLTSLSVISILTKEAAIQTGFFSYEKILQVIKMVAIGITMSAFLSFLLWPVSARKDLRETMTEAADSAGEMLSIITRGFLTGSENEIRSSIFTNAQKKHKKAFAKMNVCLREAKFEHYILGTESLYKYESNLVNCLERLFQSLGGLRSAAMTQFTLLKEIPVHGNSMSINSSHYVPEIYSDTLLPTVDSCNEGFKAQKLFERVFDVKCITENDRNNIRFMDERIVHGLSQESNFFTLTARNPSQIFSRFLVLLGPSIKSLAFTLYQTLQEFPIKEKPASAKEVIDQFKKSLRCALQLYSDARSKALTELYKDKELNIEWPLSIEADFEEVAASCGYFSSCLHTFATEMLKFMEILEELKEESENSRRSWSWIRFWRKTWKSQESPSEEEEALIPKIPETRISRKIPDLELKSLIKRKQSMALNEPNMRQTLAYRILSFIKYLSRDDIRFAIKVGIGASIYALIAYIPATRPFYQHWRGEWGLLSYMLVCSTTIGASNTVGSSRFIGTIIGALIAITIWIICQGNVCALAFCGWLISLPCFYLIIAKGKGPFGRYIMLTYNLSCLYSYSLSIEDGDDDDDEGGIAPIISQIALHRLVSVLTGVVWGMIVTRIIWPVSARKEFQDGLSLLWLRMGLIWKRDPLAALLEGDSPTPYMNLREEFALNRYLLRLENLRNSAGSELELRGPFPVKEFGQIIDSTTKMLDAFHSMNIIIRTDLIVTEGEKCLLQYTADERAQLCLIISHLYQVLASSLKLEYPVNHPLPSITKSRDRLLAKIFQYRKDSSDAESKGKTIPKDEDYELLYAYILITGQLAEEIGKVEVEITKLYGVMNEDSLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG46</accession>
    <name>A0A0B1PG46_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000347">
        <property type="protein sequence ID" value="KHJ35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG46"/>
    <dbReference type="STRING" id="52586.A0A0B1PG46"/>
    <dbReference type="HOGENOM" id="CLU_041575_4_0_1"/>
    <dbReference type="OMA" id="KTFGPHP"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="33049" checksum="EE8D42322EB566A8" modified="2015-03-04" version="1">MSLETFSKLPNGLCALKNIFKNSSALSLAPQLARSLTTDASTLSWKQNITSPLIQSTSKKSVIDFRSPTVLTTIYKFPTMEPLRFELYPSKHLYLPLRRDILHRAIIYEGDSTRQGTASTKTRYEVHGSHRKVRPQKGTGKSRLGTRQSPAIRGGGVVFGPKPRDFSTKLPRKIYDLAWRTALSWRYRRGELVVCEDGMDIEFPDPYYARHIFEHNRWGKSCARSLLVVKSKPKNLIEAMANAGEDGRIKTTSDIDVKNILELGRVVIEKSALDKILTEHQSDLASRDNFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG94</accession>
    <name>A0A0B1PG94_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g3021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000211">
        <property type="protein sequence ID" value="KHJ35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG94"/>
    <dbReference type="STRING" id="52586.A0A0B1PG94"/>
    <dbReference type="HOGENOM" id="CLU_066912_0_0_1"/>
    <dbReference type="OMA" id="KCMEEGT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="287" mass="33396" checksum="3BE0A5092B84F645" modified="2015-03-04" version="1">MYSKGKHDFDANNQNVHESRHFQVYGKNLKLNKKRRSQEQNSHIIKSSSSINAIKKKLRDVNRRLGRPETISAEMQVEFERARDAYQLELNAAIAEKTRQRMIKKYHMVRFFERQKASRMIKRIRKHMLAANSIDEVHSLEKQLHGAEVDLNYTLYHPLSETYISLYPRNKSSAEECNSNQDIFKKKPPIWYEIEKAMVNGSLEEIRHRMSAKQVLFSKSNFESSSHTSKQGNTGNSAGLDHDKNKSKYRKVRIESALSTASKSHESFNIEHASDDKDNDSDGDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGL0</accession>
    <name>A0A0B1PGL0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2032</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000041">
        <property type="protein sequence ID" value="KHJ36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGL0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGL0"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000910">
        <property type="term" value="P:negative regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000356">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="79"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="570"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ36385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="860" mass="95241" checksum="5F1169575A8ECDDA" modified="2015-03-04" version="1">MVLQNSNMSAAGQFMNPGPAPRPPINSPRLHYSHSNSLSENMAQMSVFPSTSRGSASSTTGSLVSLPVQRQPEVQGGLAVIKQGPAYVKEGKTFLTPWKQKFLVLRKEALDFHKTEGGKISYTVVLKDVLAVSRVEAAGTIFEIKRAINGTSNNPGDDEGPSRSIQVRVKSDDDLYEWIDFIYARCPGMGGVSNPTNFNHSVHVGFDSQTGEFVGLPPEWSKLLNSSAITKEDYERNPQAVFEVLEFYSDITRKAQNPNQYSNMPSVPAALSNHAKQMGYNGASNIAPYRQIQSSQSSQNFGNPVTTSGMMRRLTPPEANQRQQKLSITSNQYDQTSESQRQREREAIEEQNRKDIEAYNASLPKTRVLTSQMEIGVFGNGNGSTNDRYNPTRAAPPTPTSTRHQQNQQSVSMRPHRQVPSAPNSINSIKPQIVKQQGISAINNNDSPSISSRQDQSAQRIPENRYQNGTNGQQQQLRPNVNGQNQPSTRSPAPNNQVKPLYVNIKPSPATENGIKQNDAVRAAEAALTAKSPIAEKERKQDVRMSTMSESEVMAKLKEAVSKDDPNLSYSKQKKIGQGASGSVYVAKVKENAISPIAREVLRQQGPKAQVAIKQMDLAHQPRKELIVNEIMVMKDSRHRNIVNFLDAFLRNNYNELWVVMEYMEGGALTDVIDNNPNITEEQISTICLETCSGLAHLHAQDIIHRDIKSDNVLLDAKGNVKITDFGFCAKLTESKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPRLKKPEKLSKELKAFLSVCLCVDIRSRASAAELLEHDFLKHGCPLGNLSDLLAFRKAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI56</accession>
    <name>A0A0B1PI56_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5665</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000121">
        <property type="protein sequence ID" value="KHJ36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI56"/>
    <dbReference type="STRING" id="52586.A0A0B1PI56"/>
    <dbReference type="HOGENOM" id="CLU_008515_1_0_1"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="773"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="426"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="817" mass="91492" checksum="D007D91BB9DF7DEB" modified="2015-03-04" version="1">MCLLFLYNSQTHTYKSHKTTLIMTDGSTSNTRHKVKSNGRGRKELQSARDNTRCKNDAQNLPKKKYGAQKDVEKPEVTPGKLPSKTNIEPTKSDNESCIICASDIVHESFGPCNHRTCHVCSVRLRVLFKDKTCTLCRVSRKDKWSFRTKRFEDFTEEYFKKMDFPSIEENIGLRFDTSQIRDDTLWMLAYNCPEKNCDVACISWPHLHDHTRKVHGKKICDLCSKHRKIFPHEHDLFTDAELSKHMKKGDKSPASGNQTGFKGHPLCIFCGNRFYGDDELFKHLREKHERCFVCDLANPDMPPSYYVNYEALHLHFVQDHFICKMKDCVDQKYIAFVSEFELRAHMIEVHGSSLSKDDLRDLRNIDLSDFSYRQPYMQERRDAVGQRGNISNRGRGRVRGIGRDPNVDLPQPLSSQPLRRDEQAFQRQLAVQSSQSVTTRNSVHQNTTPASQISNNTPKSQSQVTRSPQTSNNLESANIGASNSSELIRASNNPRFRSLKDQALSERASLLLQKDPSKISQFQSFFIAYNDSTIKASTLIDNLISLLADSPSNSIGTLIREIADLTEDRKKAEELRKAWNDWRAINEDYPSLPTSNNGGGSSGILSWAARTGNFSSSGHNAPASSVRIINLKKSTTNSDRSFISQPKSWGSQSIVSSSVGEGSSSKKANSSSAFPSLPPSGSRDINISRKSGTKIWGSTVNPTSNSSSNIQDNIGSSSTASLILPNGRNNEAKKGKEAFPSLPTIEKPQGQIFGNLNRVVKKNTAAIKDNAWRGNGETSYNTKDLQANVDLTNEDSGSKGKKKGNKEKKQLLMGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUG6</accession>
    <name>A0A0B1NUG6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005643">
        <property type="protein sequence ID" value="KHJ30012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUG6"/>
    <dbReference type="HOGENOM" id="CLU_2777774_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061494" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="69" mass="8150" checksum="F684FDA916578803" modified="2015-03-04" version="1">MLICTSQWLVMLSTEFLSLIDYVETHINISTYKFLVLHILFHMHAVVLDDISRQAQLTSALQLEHFLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUH5</accession>
    <name>A0A0B1NUH5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005605">
        <property type="protein sequence ID" value="KHJ30022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUH5"/>
    <dbReference type="STRING" id="52586.A0A0B1NUH5"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_2_1"/>
    <dbReference type="OMA" id="CRKQSCV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="194" mass="21528" checksum="0C4FDB21EB842D73" modified="2015-03-04" version="1">MAALKKLLRYLRSTVSHRLRFGPGGDQSLVVYSDADWASDKNDRKSITGAVGILCGGAIFWLSRKQKSVATSTAEAEYTAMAITAKQGQWIAQVLRDMGYPQYISKNAMTVQTKGDNQGAIHLVKNPILSDRSKHIDISYHYVRDLAEKKRIAVEYIPTNKMIADGLTKPLPKVGFVKFVRDLGLVDKDENGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NV97</accession>
    <name>A0A0B1NV97_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sporulation protein rmd8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004618">
        <property type="protein sequence ID" value="KHJ30262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NV97"/>
    <dbReference type="STRING" id="52586.A0A0B1NV97"/>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="OMA" id="NERCQVF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="312"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="66782" checksum="5C057782A893D4C6" modified="2015-03-04" version="1">MAKSFYGKKIPSVLVGVTNSRDRSHESAKSQELRSSTNGNQVMRRSISTRLTTVDQMLQNVSEIPSGQSRLQPMLRKTTKKRGIGLLGLGARCQNVPGRSTRVVEKLVLIPDALPNGHDSEEEIVQSYLDYKEEEGPLNDVERDILKKRGGVRGKSYAERLPKAKRTEKLARVTAYCTAQGYKTKATAAFVKKAHGARTKLYDDCLYTVYHLPLLPGVEGIRIRSSPVLKNPGGKEVLDEEIERSEQRDYYEDYFDDDDKYLVGEVEKDVEEDKLCRDIARQDKNIIRNLAHSGKRDNPNRIASNASTFAEMFVFSYGVVVFWNFREKQEKDILADLTFSNHQKSNSLVSRPLEQDDYEKEEFHFEYSSYVKRSRVFNDMITLRSGDHMIKLTISHAIAQSTKLCLFEEQMNQTMANAQHIPKHLALTGQLGLSRCQIVKILGNLFKSRVDVNLSSNILDVPNFFWDSEPTLHPLYSAIRDYLEITPRIKVLNERCKVFLELAEILSDSIADTKMSTITWIIIALIIISICVTVMEVGLRSLIFARSRPNNDHKLFDGTKNWTNVQFTSQKLMDLCGSGVLGMSFTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVT5</accession>
    <name>A0A0B1NVT5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cardiolipin synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004162">
        <property type="protein sequence ID" value="KHJ30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVT5"/>
    <dbReference type="HOGENOM" id="CLU_164169_0_0_1"/>
    <dbReference type="OMA" id="PSHKLLW"/>
    <dbReference type="OrthoDB" id="5193244at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080355" description="Cardiolipin synthase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Cardiolipin synthase N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="112" mass="12312" checksum="6C762EB30757B632" modified="2015-03-04" version="1">MTNLLHSKLLFFLQLYLTSISVAAPTLIAADISGASPGDALKYGSGGSLVGFIVLILDIIVFIEVLKSDRLVSHKLLWCVVVFLFPIFGLIIYWLFSHRDAYSRSSGYESIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVV6</accession>
    <name>A0A0B1NVV6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative air1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005118">
        <property type="protein sequence ID" value="KHJ30108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVV6"/>
    <dbReference type="HOGENOM" id="CLU_2656302_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="76" mass="8608" checksum="B6ED885606AED2B9" modified="2015-03-04" version="1">MEQPKEFKILREDFPVEIAGVPLSTKIASGKNVDNSALISILTISSKMRIPGLQINRIRWLQDGKEHEKARKEGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVY4</accession>
    <name>A0A0B1NVY4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004039">
        <property type="protein sequence ID" value="KHJ30542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVY4"/>
    <dbReference type="STRING" id="52586.A0A0B1NVY4"/>
    <dbReference type="HOGENOM" id="CLU_1864789_0_0_1"/>
    <dbReference type="OMA" id="TRTLQWH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16241" checksum="185393F19498BAC9" modified="2015-03-04" version="1">MNYRGTPYELHRNLSRAQSSIATQVRSEHNGLNSYLYRRKVPGVEAPSCQCGYRSQNVKHMIMACPRWAKGRGEILRKAENRSFKAMMNNPKDVARITQWILNEGKLEQFRLIGAIETVLKQRGEEKKLRQTRTLQWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX74</accession>
    <name>A0A0B1NX74_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003384">
        <property type="protein sequence ID" value="KHJ30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX74"/>
    <dbReference type="STRING" id="52586.A0A0B1NX74"/>
    <dbReference type="HOGENOM" id="CLU_125051_0_0_1"/>
    <dbReference type="OMA" id="NGKQWHD"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="117" mass="14100" checksum="928C7C420EF22641" modified="2015-03-04" version="1">MTSVVSLQGPNQLPNSQGMRKNGKQWHERKTAFRLKVGNSSYAKRVEDRKAMETMKAKEKEMKLEKEDIRNRRIEALRAKRLAKEEKVRYEKMAETMHRKRVERLKRREKRNKMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXJ3</accession>
    <name>A0A0B1NXJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003247">
        <property type="protein sequence ID" value="KHJ31112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1NXJ3"/>
    <dbReference type="HOGENOM" id="CLU_056776_0_0_1"/>
    <dbReference type="OMA" id="EIGQWLP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="19810" checksum="682FE000BF4102D9" modified="2015-03-04" version="1">MHTTTDCPFCNIAKHFPPSPAPKIDAYHHKISPPAYVLLSTPLCLAFLDILPLSSGHVLLITRQHREKITDVKEEESRELGVWLSKLSGALARVTDVWDWNIVQNNGAAAAQVVNHIHFHIIPRPALTPELRNKSFTMFGRGHRSNLVHHEAAELVKKLKLEIEKETNISNRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXL6</accession>
    <name>A0A0B1NXL6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003721">
        <property type="protein sequence ID" value="KHJ30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXL6"/>
    <dbReference type="STRING" id="52586.A0A0B1NXL6"/>
    <dbReference type="HOGENOM" id="CLU_007625_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="413"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="752" mass="85565" checksum="C2C4988D374DD8A6" modified="2015-03-04" version="1">MGERMSSGESLDNTSNVIDSLERWQHEPKYKDFQENTFSTSNIEKTSHSSIDTEIEVKNDILKSGPENSQSSNIRKDKEQPLKEYIDFRSGNIKSGLEHTKLNAQHDFSYQNLDQSIPLQSLEISNSTFDELNSKTPHDELEKSLLTSDTAFVEKSSISEDEKVENPNPEIKSIIDQFSERFDSLRHESVVLPRLEAASSILGDSIQHPPRKSSLEPIKPKKNFRSSKDSENQPNQQNSHTPDFRPSRSIPSAVTTNILDKRNKSLEASISPSFQQPPSPEPESEPIIPFDFHRFLEQLRHKSADPVAKYLRSFLQEFGKKQWMVHEQVKIISDFLIFISNKMEHCEVWAELSDSEFDNAREGMEKLVMNRLYTQTFSPTIQPSQPSPGSKLKRKGLERPVGPGRRGQHQEDVERDEILAQKVSIYGWIKEEHLDISPVSDSGKNFLVIAKRELLKIKAYRAPRDKIICVLNCCKVIFGLLKHLKSDSSADSFMPLLIFVILQANPEHLVSNVQYILRFRNQEKLVGEVGYYLSSLLGAVHFIENLDRTSLTISDEDFERNVEAAVSAIAEKHQAQTHEIIQVSPEAISQKNEQIPRYLTEVKSLNTKKPNSAEELQSNDGSKEKAPIGSLLQTIQRPLSTMGWIFSEDSSASQNLPARMPRFDNVLFPISSSQSSMENHEDVTCQKDDQACNFHKENNTEIITERQINTSITETCQSQRSEYSNIAETLACMFPDLDKELIRDVVVQKEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXN9</accession>
    <name>A0A0B1NXN9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003684">
        <property type="protein sequence ID" value="KHJ30738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXN9"/>
    <dbReference type="STRING" id="52586.A0A0B1NXN9"/>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005109762" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="27"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="327"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="480" mass="53886" checksum="465FE02475DD0A70" modified="2015-03-04" version="1">MKISAIPLTMKIIFVILLGIISIAEAASSSGNKLLILLEESIEDTRYSKYIADLKDRDFQVTIESPKNGKLTLFELGERVYDHLVIFPCKTKGLGPNFTSQLLLNFLNKGGNILLTLTSSKSTPTALISLLLELDIHLPTDRSSFVVDHFNYDILSANEKHDVVLLPRPDAIRPDVKNYFRGDGKGGEVIAFPRGVGQTLGNNSPLLTPILRAPRTAYSFSSNDKNAIAEEPFAVGPQLSLISTIQARNSARLTVIGSAEMLEDTWLDATVKRSVAVNGADKEAKEVKTSNQALLKEVTGWTFKEIGSLKVNEIKHYLQENDIQIGPTNPKIYRVKNFVKYSIEISEYSWDKYVPYTPPKGDVIQLEFSMLSPFYRVPLQLTSSSHNSSVYSASFRLPDQHGIFNFMVNYKRPFLTNIEEKTTVTVRHFAHDEWPRSWAISGAWPWIAGVWVTVAGWIVFIALWLWSKPVKKSSFNKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYM6</accession>
    <name>A0A0B1NYM6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator of g protein signaling domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003271">
        <property type="protein sequence ID" value="KHJ31083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYM6"/>
    <dbReference type="HOGENOM" id="CLU_037891_0_1_1"/>
    <dbReference type="OMA" id="WTSCESA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="93"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="44265" checksum="FD65F0B92D708A37" modified="2015-03-04" version="1">MKYLRSPMHRTKRRIPSFQFKKSSNTAPSPPQSPPFLSSWNPDDERGFMSKSNGHGRSLSLQIPTVTFQSPRQPTLQEILSNSAPSPWTLSAFMAYLSQNHCLETLEFTMDAAKYEKQYHAMVTPLNLQPNNNTPSLEIEYVQKLWTKLIDAYIRPNGAREVNLPSDVRDKLLSLPCETTSPDPSELVKAVKITYELMDQSVLMPFLSSVTLSQTSERPHSAWPCETTPSSAFSSSERFSQRFPSSPRCRRNSHHMLSAESNVSLISAISQRPSHHPCRSGFRISNFIFGGSPLVSVTSEASDSSTDDEGSNICDLVTPPTTPSTATSGWKKMGAKLYNRKKIRSHRPSASVGHLSVPFTPESCKRSPSSPASIKSLGYITTPVEEEEKQLVIINEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYR5</accession>
    <name>A0A0B1NYR5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003237">
        <property type="protein sequence ID" value="KHJ31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYR5"/>
    <dbReference type="STRING" id="52586.A0A0B1NYR5"/>
    <dbReference type="HOGENOM" id="CLU_062474_0_0_1"/>
    <dbReference type="OMA" id="SIIDWAG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="361" mass="40236" checksum="B211D5EC61BC5FF6" modified="2015-03-04" version="1">MLLTDILSDEEYNSSEDSDFTPGEIDNKHEVVTLLSDSDSDSGLDSESDSDSNNPLAKKRKHLLDPEVEVAEIHNSGDEKITSQPKHELKSTKKAKFRNIANDRGGGIVKTRSQCSQEKKVIESQHKNETAVTIDVDAVWEAMNSGKPLPNSSEPPETKNSQSNSEEISLSSTSLQTKNSSNAQVEVCSRSKAYDEGPNSMIKIKQTYKFAGKFHFEEKIVARGSAEAKLYLKSLSDASKVNLVELETQGQVLKIKRPPKLARTSIFEPSSHKMPQRTDLRLGVRRQNPLVASDLMKEGKKLNTVEKSIIDWAGFVDKEGIADELEAASKSKHSYKTHQEFLARVEQKKEEESRRARGFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ71</accession>
    <name>A0A0B1NZ71_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002648">
        <property type="protein sequence ID" value="KHJ31697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ71"/>
    <dbReference type="HOGENOM" id="CLU_2265714_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="103" mass="11700" checksum="1EF9C212F74DF9F6" modified="2015-03-04" version="1">MLPAMRKVIDVVEFSGADRLLWPCWHIQARGKVESCGPDPNFQFFAVFSNLKHIAAKNFTPWITRNITTNIATYEGLLKELVRLCNDLAQEAKALINLKLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZD7</accession>
    <name>A0A0B1NZD7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005460">
        <property type="protein sequence ID" value="KHJ30051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZD7"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="10689" checksum="C3769A7C3AB9763D" modified="2015-03-04" version="1">MAATKCRNCGGPHRSDSRRCLIRPTRSGIPTKEQLKSYRQAGEREFQAVARAKEADLKASIAEESMLEVDSSQIKDSNSNESQASTVEDSTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG4</accession>
    <name>A0A0B1NZG4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transmembrane protein pft27 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002974">
        <property type="protein sequence ID" value="KHJ31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZG4"/>
    <dbReference type="HOGENOM" id="CLU_040186_3_0_1"/>
    <dbReference type="OMA" id="YWWVTIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059249" evidence="8">
        <location>
            <begin position="24"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="58674" checksum="B84BB9F9E0AC6036" modified="2015-03-04" version="1">MKCRRYPALILALNLSLSASTINIPIIDRTDISLPKHQNTEGLESGLKSPVDLNTKPKYDIGTKDAPVDGKDGKPHAGPWVGTEKDTTKTSNNLKSSTKPHVSNSNVSDENNITDVMLSQGNNIPETNDGVMDDPTREPPKHGTTGTGGGVSEKDKARKAQEGQTGERFENKPASPKEAPLHSLDTKADAKNEKSKITNDEVDPVNSLSGLEKPNDLPDRLSNLPHPLPDSAKKDHLETSKLEKKLSPKYDLLQSKENDRFLQPLHSYFLSLTMILFSEIGDKTFLVAVLMAMKNDRLLVFSAAFSALLVMTVLSATLGHAVPTLIPKRFTNFLAAGLFIIFGLRLLKESFEMSSDEGVGAEMKEVELELEKKEYLAFQAKKERSSISPYNLEMGFSRSRTRRSRSRSRLPSIPRSPSSSPERSPSPQQSRVKSTIKGLTNLLSLLLSPAWVQTFVMTFLAEWGDRSQIATIAMAAGQDYWWVTAGAVCGHAACTGVAVVGGRVIAGKVSMKLVTQGGAWSFLVFGVIYLIEAYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZR5</accession>
    <name>A0A0B1NZR5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative calnexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004045">
        <property type="protein sequence ID" value="KHJ30535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZR5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZR5"/>
    <dbReference type="HOGENOM" id="CLU_018224_1_2_1"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005110162" evidence="9">
        <location>
            <begin position="22"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="584" mass="65285" checksum="36B2054BD65D7DE5" modified="2015-03-04" version="1">MRYSPSAATLSAIIWFSGVFAEEKQAVLSETKSAITSTTSSATESSSTPLPIFTPSTIKAEFVEQFLENWSDIWKPSHAKKDTKDSAKSNEEWAYVGEFSVEEPIIFKGMEGDKGLVLKTPAAHHAISAKFPKKIDNTGKTLVVQYEVKLQNGLECGGAYLKLLRDTKALHQEEFSNASPYVIMFGPDKCGSTNKVHLIINHKNPKTGEYEEKHLKSPPQARITKTTELYTLIIYPNNTGIIKLNGARVQQFNLLEDFDPPFTPPKEIDDPKDSKPDNWVDEQRIPDPEAKKPEDWDEDAPFEIVDEEASKPDDWLEDEPLNIPDPQAEKPEDWVDEEDGDWIAPTISNPKCEDVSGCGPWSKPMIKNPAYKGKWIAPYIDNPAYKGAWKPQKIKNPAYFEDKNPSNLDPMGAIGFELWTMQKDILFDNIFIGHSVEDADQFADDTFHEKSPHEKLSEIAQKEKEELTKPSSPSDLSFKDDPVLYIKEKLSLFFSIAQKDPFQAVKFVPEVAAGISTLIIAFISILIGTLSNSSSNSKKNTEKNSSVTENPKSVTETIKEGKSEAVTSSIDSSKADQKKVQTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P092</accession>
    <name>A0A0B1P092_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003728">
        <property type="protein sequence ID" value="KHJ30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P092"/>
    <dbReference type="HOGENOM" id="CLU_1300501_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="212" mass="23735" checksum="19D5E133FA5538D4" modified="2015-03-04" version="1">MSCRSSNPISRILNPSSSDNPLSKILNPNDCENPHSRLFNSSVEDPHMKFNNSRNAQSGAVPPKQNFQNSVLKKNNTTNFRHEAATNLQRPVKNMDSASSGLQGFNESSSSSPFNLPQTRNPRVNDSTLRRNSTTRGETLDEFCSRRLSEAREARDVRDMKVEAAIQDLQNGDFSCVAEAARAYNLKEKSLRMRVKASGLQLPLNPWQNKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0J8</accession>
    <name>A0A0B1P0J8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative duf2418 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004245">
        <property type="protein sequence ID" value="KHJ30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0J8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0J8"/>
    <dbReference type="HOGENOM" id="CLU_687344_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45894" checksum="C2B167BF05EF6281" modified="2015-03-04" version="1">MPNLLNGRSLFHLINDCLQIVLNRLRISEIRGISDWGTSKNGNIAALMSHFLYLIALTNLKSSKEIQSLVFTINHPEYKLLNYTALLIINILPAFSILNTIYTFGRKKNSCLFRNSIHAAQDTSSSQSVKISSIRGSPLGFDNIFNHYRRLNHKSRIDQGSLHSTSEIAVWDPILPCLRIFCLFSPGHVIIYWLFFPQNAPDTQPALDILKVIFLQLLMSLQLFLLEIHYIQRAKDISIIHGNVMNEYNVKFVYPRLNPTVRDSGTQSTRIITSAALSLDENVDTFKTSSMYHESPTISQYLEFENISPLTSQQYLRLAVSQSSPSEIETISSYSYHSPIKDPIIKQSMVDISNDFELSPSNILSPQSHDNYPIFSVDSYQEHKKDTFSRRKYERGPSFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0K9</accession>
    <name>A0A0B1P0K9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004209">
        <property type="protein sequence ID" value="KHJ30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0K9"/>
    <dbReference type="HOGENOM" id="CLU_002055_3_0_1"/>
    <dbReference type="OMA" id="LATRICC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="744"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1002" mass="114490" checksum="FF3FF43A204FE475" modified="2015-03-04" version="1">MLIGSTDEDLHELVQLDFQKWDSTIFNKVRLPTLQRFRKLLREHGIYVRKTKVSCSIAIAEALNSQYREWTKSEVEEIIKDKTFNYVSVKLQYIKEQLQTQNTISSTLPTPSTIPTPMNIDTPSPKQFGRPINPNQNIPKVAPHNSKHPNPNPNPSNPQIHIQPSNNFPSITQPYNNYLSNNQQLGNLSKQFNEEMKYNGDEANFDFKLTIFFNTCQRAGLPENSILLAFPIMLRGNAQEYYYNLVHNSPNIEFLQLCQSFGDHFEGEELRRNVLDEWNSFTLQQTKGLNPEKSILNCFDLMLQKLRALQHGLRQELRNDYFLHNKIITACRSVKACSYACFKPSENVTGLINDIRSSISTWESCHPNFNSNNSSSINFTERKFRFQPYSGNQNKTSIRNSHTTRQPRVFNRKRKCIVCHKEGCWSSNHSKSEIMNAKRQYFERMNRPNNFNQHFQQFVSEYEKELETSDDDSIDNFCETLEALILDSSSSTPENQTDPHLIESSTFLTSIGPINGSSIVEDLANRSFTHALTASQRTINNSLSTSVYMQSQRYNSNEFFGIMIDTGAATQSTAGYNQFLAYKNLTNIDLNKTTAGKVTVKFGIGSATSTGSIVIDTPIGAVEFHILKTDTPFLLSIADLDRLKVYFNNVTNQVVTSDSLNFPTVRRFGHPFLLWKISPQSLVQESFSFSESYLTEIELHRLHRRFGHPSANRLRSILERSGHDNIDKSKLETLTKFCVHCQKHGSSPGRFRFSLKDDFNFNYTIVIDIMYIEGKEVLHIVDEATRFQAARWLDNVTSKHVWDTLRQCWIDTYVGPPDYILHDAGKKFISREFVQNAAAMSTSTKNVPVEAHWSIGLVERYHQVLRRAYEIICEELKTYTLSKEMRLQMVVKAVNDSAGPNGLVPTLLVFGTYPRMTHIDPPAPSITQRASAIRKAMEEIQQLRSRRLVADALNQRNGSSVASLHNLPLGSNILVFRVGQANRSGKWTGPFELIGIENETCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0L9</accession>
    <name>A0A0B1P0L9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004409">
        <property type="protein sequence ID" value="KHJ30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0L9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0L9"/>
    <dbReference type="HOGENOM" id="CLU_000680_26_3_1"/>
    <dbReference type="OMA" id="EREDATH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="497" mass="57111" checksum="0987F0606FB4C4F0" modified="2015-03-04" version="1">MDDITVAVASTSITKNIRLLTEATKRLFLIAQNISATFELDKTELIHFHRKRQVINSPLDIQGITLEPKEIVKWLGFWLNQRLSYETHVDKRLQLASGVIQNIKRLTSSSRGLRLNQIRQLYLSCVTTVLDYGSILWYQKYGTEKHLNKYQRFQNIAVRMITGAYYGSPAKALEVEAAILPCRVRHLKLAYSYALRILRLQTIHPIQECLFTSQRNESSSILTSKFNLLAHLIDNKTQIVRLGKLLSPLTSNWRLEHSDFSWNPPWKSLNIAISIPKLEKQVLRTRHETLFSQIHPSASIIYTDGSRTIGKGSSIGFVIYLPYTREAKFYSFNLGDGVGITDAETYCILKSIKTLKNISSSRKCYIFSDSQAALLRIKNANNYFCHQIRRHAHNYQISMEWCPGHIGIEGNEIAHGLARKGAELEIHPQNIYITISVLKENANQEILKAWRKIWNVELLREEEGRIARGLEISAEKHKQHISKLVWASEICEPIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0P8</accession>
    <name>A0A0B1P0P8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004332">
        <property type="protein sequence ID" value="KHJ30394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0P8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0P8"/>
    <dbReference type="HOGENOM" id="CLU_031138_0_0_1"/>
    <dbReference type="OMA" id="CTAYERS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="50276" checksum="8870970635B2BC0B" modified="2015-03-04" version="1">MNTTFRLRRKAIKIQVDDEEDDDVAANVKFSSSETSSTLLSNLTQPDPKLQKRKISGNLEAGIDISENSKETSINHGNFEFINDDKIPEHKTVFKKKERKKKNMTKLSFGLGDNEFEETTYNSSKNKLQSTKNFKDGIIQASKFRKGLSLQSLPGHFAEANKERPTYNKDYLNELKNSTPATRSYSLSETQNLIGEEDEINTTDLLETLIPYPQSSAAIIPTEAEIREKKERRSRLAREADFISFDEDVNDCRILLPQSVNNQSRLVRDDEDFAEGFDEFVEDERIALGKKQERQARRQKRKEIAEMIQQAEGSTDAESDDSEAERCAAYENAQTRAGMDGLQRNDIEEESIEERMPTNITQLPILSECLKRFHNTLDSMEVELERQKNMLLEAEQEERDIITRESEVQALLAQAGERLEAMSPGLHDIAKESTSNFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y4</accession>
    <name>A0A0B1P0Y4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002507">
        <property type="protein sequence ID" value="KHJ31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y4"/>
    <dbReference type="STRING" id="52586.A0A0B1P0Y4"/>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="50876" checksum="0CB170C0946880F7" modified="2015-03-04" version="1">MSEAQATEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQVSRAAKMLAEEYGTASNIKSRVNRQSVLSAITSTQQRLKLYNKVPPNGLVVYCGEILTTEGKERKVNIDFEPFKPINTSLYLCDNKFHTEALAELLDADQKFGFIIMDGNGALFGTLSGNTRDVVHKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFISNDKVNVAGLILAGSADFKNDLNQSDLFDNRLQSKVIKVVDVSYGGENGFNQAIELSAETLSNVKFIQEKKLIGKYFEEISQDSGRVCYGVEDTLKALELGAVETLIVFENLEITRWQLKDVSGVTHILHTTKQSETSNREQFMDKDTGQEMEVVATDSFLEWIADKYKEFGANLEFVSDRSSEGNQFVKGFGGIGGILRYKVNFEQLVDDNNDDDYYDGRCSYIRNKFHTNNVRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P135</accession>
    <name>A0A0B1P135_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P135"/>
    <dbReference type="STRING" id="52586.A0A0B1P135"/>
    <dbReference type="HOGENOM" id="CLU_1571353_0_0_1"/>
    <dbReference type="OMA" id="HDATSYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="17806" checksum="4720E464980353C6" modified="2015-03-04" version="1">MLPFGVYSVFHVATYTRTVLVPTFEAGSLNASAQAPKPNSIADNIGRFVKRYYDASMGLVAILEISLWGRILLSALTFSKGSWILLVIYTIFLRARYAQSSFVQTQFRNLEARIDSLVGAQSTPPAARQAWGNLKGGLRVFHDATSYQRQTAASQSAPKKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P197</accession>
    <name>A0A0B1P197_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rrna processing protein bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003900">
        <property type="protein sequence ID" value="KHJ30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P197"/>
    <dbReference type="STRING" id="52586.A0A0B1P197"/>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="OMA" id="TKLPVIW"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="490" mass="56045" checksum="DB0785C6F115E805" modified="2015-03-04" version="1">MPKISTVPSISKYTRRHNPLEADITAVASVKSRPPKRQKNFQNEAANFVDSKATRKILRMGQELEDEDLKERNSALKSAFNFDVRIEYEENEEEEENEIEYDEWEDENAEEVFEVEVTDFETFNKFLPEEEHSLLKNGWGGQKDNDSDVQGGSGTNLADLILEKIAAQEASQKSNGQKPQGGFQRSHEELQIPEKVIDVYTKVGLILSRYKSGKLPKPFKILPTIPYWEEILDITCPEKWTPNACYEATKIFISSTPIKSQRFMENIILPRVRDQIHETKKLNVHLFNCLKKGLYRPAAWFKGFLFPLVASGSCTLREAHIVSAVLVRVSIPVLHSAAAIKGLCDIAAQESSAETEGGGATNIFIKALLEKKYALPYQVIDALVFHFLRFRGIRNEQSDKMRDEELSREPDIKETRLPVIWHQCLLKFAQRYRNDITEDQREALLDLLVEKGHHQIGPEVRRELLEGRERGIPIKTDTNMLDGDDTLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B7</accession>
    <name>A0A0B1P1B7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sister chromatid cohesion protein ctf8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002396">
        <property type="protein sequence ID" value="KHJ32028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B7"/>
    <dbReference type="HOGENOM" id="CLU_090690_0_0_1"/>
    <dbReference type="OMA" id="YLYVGKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="183" mass="20399" checksum="B29B02C46D94DE93" modified="2015-03-04" version="1">MKMQNEILMTRGQTPRLISNSLPQLLRIPSGLALLELQGALNIPASHDTIEVDNAIDGDCDDPQGVGLKSELNSRSSPKGLLIGRLLFPDYDENNACNTAWMKKVYLYVGSYQKLTGEVTKLPKAIAVVQKKKSNTQERIDVITGNEEMEKTSVQLEIVDIIKYKILFSNRPEPVSNQISKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C9</accession>
    <name>A0A0B1P1C9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003852">
        <property type="protein sequence ID" value="KHJ30629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C9"/>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="188" mass="21232" checksum="AAF3CF669760439C" modified="2015-03-04" version="1">MRPLTETETQTLFNKLANYTGNSLKNLIAPLENVPNADRYVFRLHESRCYYVKLSIANLATSIPRDNLLSLGTCLGKFTKTGKFRLHITSLPILSEHARYKIWVKANGEMPFLYGGHVLKAHVGRWSEDCPEHQGVVVYSMNDVPLGFGVTARSTQETKKLDPTTITCFRQADCGEFLRDEDSLFTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P2</accession>
    <name>A0A0B1P1P2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001983">
        <property type="protein sequence ID" value="KHJ32567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1P2"/>
    <dbReference type="HOGENOM" id="CLU_081382_0_0_1"/>
    <dbReference type="OMA" id="EYEMVGM"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="23468" checksum="144696C315631921" modified="2015-03-04" version="1">MARKKRPPRPGAINEYAPLKILTQIVIVQLVYYLSALILIIFSALVAGKRFNLDLVFNWRSLRGDTTVGWMLGMIWVLNSFTGIVLMLVLVRRSKLVLDFALTLHFIHLLTVSVYSHSLPRNIIWWATQFISAGTIIFMGVWSCQWRELQPISFGADSSASHSDIVLGSLINSGNKNIHVGSKGRKLKIGEPAESFEMEGMMSNTSEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P7</accession>
    <name>A0A0B1P1P7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003666">
        <property type="protein sequence ID" value="KHJ30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P7"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="226" mass="25157" checksum="F782E7538544B86E" modified="2015-03-04" version="1">MTDSMDISQESQAPSTESSNQPPPIPPIPPIPPIPNTQYPIPNTQYPIPNTQYPFPFPFRILKPVAPSKRPVTERPSLNNSNQPNIGNAFLPKELAEIVATRQRRERAWHARLMICTTTMSNIKSTLVNFKDDVEKEEVEAFKAYLRLAIANFAVVDTSPTPPKVPTHSCPTKCSNYRLGKDKNFLKNVAIATPQIMKSVASTGGSTQEVHKLPKNPKIKQIHGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1U6</accession>
    <name>A0A0B1P1U6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001939">
        <property type="protein sequence ID" value="KHJ32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1U6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1U6"/>
    <dbReference type="HOGENOM" id="CLU_016696_2_0_1"/>
    <dbReference type="OMA" id="NAQMRYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="63961" checksum="06F6CBA2D54D6092" modified="2015-03-04" version="1">MAEQQHKSSNSPQPSPSMSNAQQKKGQFLQQAVNYPSPTYGDSPCITQFNYPPPVQPGPEPYRESPPASNSSAPLPSMRSIDPLQQQQHQQQQQQQQQQQQQIITNIPPPVAQMGAGPYYQQPPHNLAQYPNVSSGQNGQNMHFALTPTDTRQANGGRHKKEIKRRTKTGCLTCRKRRIKCDELHPACRNCQKSKRECLGYDPIFKQQPGHTAIQPAPSTIPSIGNIAVSSNPYGNQPQLLSSGFGAANITYEQALPAGPASSGQGFEYASAIDPALVGAGPASTTTVTTTTGIYSNQVPVKRSVSDLLSMGGPAPPRTSSEETSCPTSLDEVKHLYYSIYTPGLENFLETKWFSTKGLAKLLESKSLLDQFLSLIQQFAKTDQSDPKEIQYTSNVEARFIWALAGLVRSTAAEINDKKEVKTIPAIDDPVEASNRLNVFEALLTGKVATSNPLTTPIAASTDQLRLRELEFWYTLGNFVCIPYEDSSATKSVDENLAALRNLLDTRENRDVLYSIAVARGLGQRFSEISEHDGPSHLDESDNKSKLLVAKKFVTSEAAGAGTTNVIRRLCDLASRSWVLASARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P232</accession>
    <name>A0A0B1P232_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4993</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002196">
        <property type="protein sequence ID" value="KHJ32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P232"/>
    <dbReference type="STRING" id="52586.A0A0B1P232"/>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="216"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="688" mass="75920" checksum="2C1007B6EF495E9D" modified="2015-03-04" version="1">MAVSTQFAYRTAQGVGIVDAAPKYQSLSGFQPLEGNCRCCTYSPCGQYFGWSSNEYVTVIETTEGKVVTSLKIPNVNEIGFSPRGSYLITLERPSKNEAGDAVKNLKVWRTVEEITPGSEKQVVGRFVQKSQSGWNLQYTFDEKYCARVVTNEVQFYESVDLGTVWTKLRAEGVSDFSISQSNNQSVAIFIPERKGQPAAVKIFHVPQFSSPVSQKTFFKGDKVQLKWNQHGTTLIVLAQTEVDKTGKSYYGETTLYVLSANGGVDSRITLDKEGPIHDVSWSPNSKEFGVIYGYMPAKTTIFNSRATATHSFPLSPRNTILFSPSGRFVLVAGFGNLAGQMDIYDLEKNYKKICTIEGGNPSVCEWSPDSRYILTATTSPRLRVDNGVRIWHVGGSIMYNQDMVELYQVTWRPQNFDVFPEVDPLNPVPNPHESALAYLGTVKTPSKSAGAYRPPGARGTSTPLHFKREDEGGAAYIVSNGSPHTYSNGFSRPRRQVPGAETVDSVPAGSESQAAGGDENLSKTALKNKKKREAKKAKEADAKASEALNIHDKQDDHITPERRDFVRNQSKGQQHTRAPSQQRYRNNVFQSGGARSNILQAQNQSQQDNQNSSVNSNFAPKPIDPSLASPNGVSQHSKKLRALQKKIRAIEDLEMRLAGGEILEDTQLKKIGTKTQVQAELLAMGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2E4</accession>
    <name>A0A0B1P2E4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type i phosphodiesterase nucleotide pyrophosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001787">
        <property type="protein sequence ID" value="KHJ32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2E4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2E4"/>
    <dbReference type="HOGENOM" id="CLU_017594_4_0_1"/>
    <dbReference type="OMA" id="TEMYANI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="702" mass="80888" checksum="59041B49B75C6868" modified="2015-03-04" version="1">MINSCHLKTDIEDELAPVETSRSQGIQAYEQETLQDEKELERLLTQNIQDNSSKLTLTQKVRKLLFLSSDFHLNQVEPNEKIKYKNKMENQRKKRKEPLGIEQNSEEEVELLLEIEEGVFSDSSNEIGEKRKPSHRKRFEQRQSKFQTMAWQKKYLTRCLAATGLCVLLLLMFKQMLKCKSTRSPLMKMKSNGTTLFAPTTILISLDGFRPDFLNRGITPRLNSMRQEGFSPAYMLPSFPSVTFPNHYTLVTGLYPESHGIVSNVFWDEELKEQFYYTKPIAMNKKWWGGEPIWVTAEKQGVKTAVHMWPGSEAHIMNTEPTYLDKFNAKTTMKEKSERVLELLDKGSFQDGYNEYMRPQLIATYVPHVDADGHFYGPNTTEIRNTISGADQMLDEILLGLERRNLTNIVNVIVVSDHGMATTDIDRMIQLDDLLDLSKIDHIDGWPLIGLHPKRDVDVDELFEQLSQKVASNPNLNVYMRDKNMPERYHFSNNKRIAPIWLVPMTGWAITTKEEFDIKESKRKGLQYHPRGLHGYDHEHPLMHSIFIATGPAFPQISSNRIKPFQNTEVYNIVCYTLDLMPSSNNGTLPLPLLPIDPQEPDFTYEIPVDPEDSLVSIPLEDQNKTTISFPLASVTPDEISSDNLDNKAEINSSENFDFLKVGFNWLSSKETDFREWFEEISAKIKALSNKSLAWIDKKPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T5</accession>
    <name>A0A0B1P2T5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="JNVN01002709">
        <property type="protein sequence ID" value="KHJ31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T5"/>
    <dbReference type="HOGENOM" id="CLU_014602_3_1_1"/>
    <dbReference type="OMA" id="PQNRSEC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="38498" checksum="3C29444984F1CD3E" modified="2015-03-04" version="1">MLVATRSLSKEEQNSVISNVFEMNPFELGTWDTNIAGFAPMEYIGSNFSGGTVPSDGTCVKGFDQVGFLIGATSTLFEEALNRAVNSTGISIFRSALQMLSKGNNDVAQLQPNPFFDFNPEVNPIVKSEELSLVDGGLDGQNLPLLPLLQQSRKVDVIFAVDSSADSQNFPNGTALVATYERALKGKFNSKFSFPSIPDQNTFVNLGLNKRPTFFGCDASNVTGDAPLIVYIPNSKYSAASNISTFQSEYKTSFRNKMIQNGYDFSTGKNGTVDPLWPACMGCATLSRSMTRTKAPIPAACQKCFSSYCWNGTLDQTPVKVSYAVRNFNNYIALTALFLILNFTYQLAANEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P307</accession>
    <name>A0A0B1P307_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003300">
        <property type="protein sequence ID" value="KHJ31064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P307"/>
    <dbReference type="STRING" id="52586.A0A0B1P307"/>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="22942" checksum="A677E23978423F2C" modified="2015-03-04" version="1">MSPLNKIAANSTSRQRPSELENSIASALYDLETNTTDLKVALRPLQFVSAREIEINHGKKAIVIFVPVPSLQGFHRVQQRLTRELEKKFSDRHVLILASRRILPRPKRSSRSRTSLTQKRPRSRTLTAVHDAILNDLVYPVEIVGKRLRTKEDGSKILKVILEEKERGNVDHRLDTYCEVYRKLTGRGVNFEFPQGSVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P309</accession>
    <name>A0A0B1P309_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">EV44_g4423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002637">
        <property type="protein sequence ID" value="KHJ31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P309"/>
    <dbReference type="STRING" id="52586.A0A0B1P309"/>
    <dbReference type="HOGENOM" id="CLU_087988_0_0_1"/>
    <dbReference type="OMA" id="KPHYALW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="271" mass="30311" checksum="484025C15AA41400" modified="2015-03-04" version="1">MAGKWIEEDDDAEPTPPSSPAAVAVPRRKFEDEDEDSDVLESWDAAEDSEVEREKARVSAERQAKLEAEAAANKKSKTQRIAEKTAERARRLAEENDESSEEDEATKRKRLQNFQHESDMAHAEDLFGINNSRKITSAANAVQVEPNDPNNLLDLTTLPLFNPNTKLQFEKLRDILIPVVGQNSNKAHYSIFLQEFTKQLAKELPSHQIKKIASSLTALSNEKMKEEKLAEKGGKKSKAAKTKVTLVANKNIAAIPDVNAYDDDYGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P346</accession>
    <name>A0A0B1P346_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002992">
        <property type="protein sequence ID" value="KHJ31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P346"/>
    <dbReference type="HOGENOM" id="CLU_1628279_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="163" mass="18410" checksum="1AE07F58EE335BA1" modified="2015-03-04" version="1">MRIPLIDKHTMKKLKTPSNISNMQLESETNKSPRLTKIKTQFQGEIKVGMADEKLDLKKIKNESIESDLNITSKKDSLEPLCNKSINKSYPKIIKSIPSIEERKQSDNTTDVVATKVTNLLLPETYKIGKNDLSGMSQSDTRINKNQSSSILAKNFKKSEEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P377</accession>
    <name>A0A0B1P377_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative arb2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003222">
        <property type="protein sequence ID" value="KHJ31134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P377"/>
    <dbReference type="STRING" id="52586.A0A0B1P377"/>
    <dbReference type="HOGENOM" id="CLU_027515_1_0_1"/>
    <dbReference type="OMA" id="HGCNCYS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="45467" checksum="33BE49F9C652DD89" modified="2015-03-04" version="1">MFRRLETGLPIDPKFPSDLKELGYFVNENDEIRNIENPKAYFQYFLTKNDRINNLHREAMNGAIRNIVAERLKNLGLDIIRLPLEVKATEPNIPIFISKEIKSKKRILVIFYDEQQDIGIFSHRILLGKGGINQGSAVNLVKYVQSMCSSSSINNDDSIGIIIANTGQLRWWRRGKKAVSQMSWYALPSKSLVDSPYEFDPEKNTVPGNRNLAEHVEYIFNHVITSHTNPDSKLDIIGVSGGAVEVSVFLNIDENWQKWKSRLSAFASIASYYSPKEITTKEFKNWTIVVGIFNTILILYIYIFIKRGRAYLISPEPCETFLAGPDGSEDISPRGLPTFSLGEPFYNENLLPLGFKTVIDWFEEVAREPSYVNPSFFRKDDLEKDEVTNNISTPYNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P381</accession>
    <name>A0A0B1P381_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P381"/>
    <dbReference type="STRING" id="52586.A0A0B1P381"/>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="388" mass="42535" checksum="4894D7B7D98B12AF" modified="2015-03-04" version="1">MAESISEGTLKQWTKKIGDYVRQDEEIATIETDKIDLAVNAPEAGTIRELLANEEDTVTVGQDLLRIELSDAPPSKNSAQSSSEIIDTVSKKIPISSDSPKSNTEDVKPPAYKNLTADLVSTEKSSPSSKIASKSEDLSTPSRTNSSLTASLGSREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSALIDFRKLYKDEVLKKSNVKLGFMGAFSRASVLAMRDIPSVNASIEGPNGGDTIVYRDFVDLSIAVATEKGLVTPVVRNAETLDLIGIESTISELGKKARENRLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKERPVAIDSQILIRPMMYLALTYDHRLLDGREAVQFLVKIKEYIEDPRRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3K9</accession>
    <name>A0A0B1P3K9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 3-oxoacyl-acyl carrier protein reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002479">
        <property type="protein sequence ID" value="KHJ31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3K9"/>
    <dbReference type="STRING" id="52586.A0A0B1P3K9"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="TCMITGG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="28157" checksum="F944A4CBF28474C8" modified="2015-03-04" version="1">MIRNSTNLSLLHGTRALITGASRGIGAAIAKRFAEEGILCLLAGRDEARLAQVRDELLMPNKNSSHFSTGKKDNEIDSCSSHRILVGNVGEENFWKQLKDDHIDILVNAAGITHYSPLCITNLNLVHEVIQTNLVGTLLGCRTVGKKMIARKGGCIINVSSLLGLKGGSGCAAYAASKAGVIGLTRSLAAELGRKNIRVNVIVPGYIDTDMTKAMTPQARTHAIENIPIGRFGLVNEIADAAIFLASNKYANNCVLVLDGGLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3L9</accession>
    <name>A0A0B1P3L9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001779">
        <property type="protein sequence ID" value="KHJ32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3L9"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="29893" checksum="B61C7D8C77DEFB3B" modified="2015-03-04" version="1">MNSTAATNYDDEFPCLEVIENQSDNHKISENTKSTKNEGSKFQLMEKVKGHLDIANPYLQEIEKDNPGVGADFMALLAEGASRLMLGQRVYYKIENGPKSNSNNSMNSWASKAAGTAIGETISLKKQVLKGNPSRGQNRKDRRIIIRLDLNHEARKSNPFQLRQTIQNLVPDKNLVSDVWKVPYGVAILAPTPAKAATLMQYKKEIENRFGNSVVERQEAWTTFVVEPIPKKIRGLEGLLDPMNGTLLEELGHIRDIMPIRYIGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M4</accession>
    <name>A0A0B1P3M4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001773">
        <property type="protein sequence ID" value="KHJ32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M4"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="298" mass="32410" checksum="877F672D6934CF30" modified="2015-03-04" version="1">MAPPLSSKSALSPDPPDAGNRVSKPKPTSGKTSRTHVAKNNPLLKTVDASCKGVAIEKVPSEGQVSTDHSYESDDSMESVIDDRRDHEHIGQDFSALPRKTQTTADVKTPSPSNNSSSKSQGSAASLMGAIRGLLDLTNDYLKNFEIEHPGFGSDFLGLIADGASRAMRGERVYRDLSKIEPNLKHPVQETWAGKAKDQSADTKVFNFKRQTLKATPPQGQSKEDRRVMIRLKSDHEARKNSSFEHRQIIQKLVPETSLVSDAWIVPSGIAVLAPTPAKAAAIIQAKKAIEDSLEMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3R1</accession>
    <name>A0A0B1P3R1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative copper fist dna binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001725">
        <property type="protein sequence ID" value="KHJ32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3R1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3R1"/>
    <dbReference type="HOGENOM" id="CLU_022327_2_0_1"/>
    <dbReference type="OMA" id="AHIKCDC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="458" mass="50870" checksum="4A58418E0E9893CE" modified="2015-03-04" version="1">MLIAGEKWACEACVRGHRVSNCQHSDRPLQHINKKGRPVSQCQHCRTLRKSRSAHVRCDCSSEKIQNKEASSIEGVAQGSCSCCHGRRCTCALKKEPLDPVPESDSDGPLNVDKRRARTHTKSPENNLTIFTNGYHKPPHKHNNTAQKYGSPYPTPRSQSLHGPSPSSLISQSEKYPGYLPKIGCSNPIIKETSIGTPGKQNLPVSICNLSDSNPTNREYIGTQLQMVNLYTSGEMDWPQSVESVSSSLDTDNNLYSVGINSASIDWSHYEGLKFNNEKFVGKPFSQPSSFTGFDFVGLDQPPLTPPPTSGDLSEIDELGPFSDRSSGESIFHHQKTGSDKEASEFCRDVEGYRSSATSSFMHLPQLQVQTNNIHLDDLDAFLKYSYQLNNQPHCISLSTNENKNSKQELSPFQDENFGIFSADDEHETFWLSNFSPNRISSGTSSNQNGLLDSFWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3U5</accession>
    <name>A0A0B1P3U5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative exodeoxyribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g6493</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001701">
        <property type="protein sequence ID" value="KHJ32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3U5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3U5"/>
    <dbReference type="HOGENOM" id="CLU_008978_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="737" mass="82294" checksum="0B237829167A0197" modified="2015-03-04" version="1">MGISGLLPLLKSIHKTCHLKNFEGKTLGVDAYGWLHRGAVACAMELATDKPTRKFVDFAMHRVRMLQHFGVIPYLVFDGDNLPSKAETEARRAKKRQESKKAGVGLLKAGKVSQAYAEFQKSLDITPEMASQLIDELRISGVQYIVAPYEADSQMVYLENKGIINGIISEDSDLLVFGAKCLLTKLDQYGNCTEINKADFSACRDINLAGWSDTSFRQMAILSGCDYLASINNMGLKTAYRMIRKYKNIEKVIQILQFDGKFHVPKGYLDSFYKAELTFLHQRVYCPFTLGLVLCNQPSNSINLEDMLYIGAYVEPEIAQGIAKGDLHPMTKVPISLTNSAGTSFQRNTWTTSLSKRQSIEIIKGTPITSFFKKRTPLVELDPNSFTPLTSPPQTLERNSNLWKTSPISQLLLDNSKVNADKSPHPVIKEIRHVNEYLATSEFRSPKRTRLCAETDLLISSKLIPLHSSSFFLPKPNKKSPKRNLGDKSKKTLTQPNPNESILDDALRISKKSINSVSKGDEEAGVQGDAKIDHDLKVVPCQDILAKLDQPQKSKPFVQPTPKIDSTKSLHVPENSATSPIEFESFKFNNKSTSISSVKASEKLIKNPSSSVQDKTQVSCVTQYENSGLEAYTTRSFVTPLQRISILANNRNKPPIKPSQTSNYYSNINSSLNSSPEESKLKLHRFVEPLSIRLPTLDDMKNIFHSTSTGSEDLIINDSEEEPLTPIGIEKTFYCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V5</accession>
    <name>A0A0B1P3V5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002393">
        <property type="protein sequence ID" value="KHJ32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V5"/>
    <dbReference type="HOGENOM" id="CLU_038480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="47414" checksum="0C59976067FEC53B" modified="2015-03-04" version="1">MIKSRLFKLKKINYVQKLNLNVKPAKSIDSSDTRPRRTRSDPDKFSASQLNTEKRQLAYESWKIHIQQILLIDRNCFPGPFYRISYVTGQLSGKAWEAVEDGVQIMNFQPSEPDKWPWKFISDLWQVLDKCYILLDTSQTAKNALDTLFQDKRAYGDFKVDFDHFADRIKYENRTKVDLLRKRLNRKISNVIDNQVNLPGPDDFLGWSDMVVSIARNLQQQEHIFKLQTPQTATRQNEPITSQPLYDIEPSDIGDPMDLSRVKISDAERKYRMDNGLCIACGENGHSARDHHRKNNPIPMPKRPSTHPLNRNFPTPVKSHTQYPHPTPMPAYYYPPMQFYNLQFPQPFPPPAPYSYSPHHLKNTAPTRLRAIDDDHESEKDKQPEILNTYRSPYDQFEELKDQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Z7</accession>
    <name>A0A0B1P3Z7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002367">
        <property type="protein sequence ID" value="KHJ32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Z7"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="143" mass="15774" checksum="8F6194C4DC887717" modified="2015-03-04" version="1">MAIAKFTAVDSSPSPPQIPTHTRPTKGDGTVKEKSFVKKAVMALPQKPTGVVLNKEVPKETSNLLENTWATVILSGKTKINPTGRQLLRPANKVKSNSSVSQTMAITDKRLFVRLPQEHEWRKLSPAGIREVIVKNYTSHPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P411</accession>
    <name>A0A0B1P411_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002686">
        <property type="protein sequence ID" value="KHJ31666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P411"/>
    <dbReference type="STRING" id="52586.A0A0B1P411"/>
    <dbReference type="HOGENOM" id="CLU_1929152_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="131" mass="14870" checksum="C11F5DA546643464" modified="2015-03-04" version="1">MIENRHQATENDVETLKEALKAEFPIQVVERTEGNLQQEIRSFKQLLEEPLLAYYGRPKHLLRRVYRRDESVQVISSMIVNPLSPLEKMMLSGIVSAFVEGLFDAELRSLSIRRSVMGCGSLLGAVLLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P476</accession>
    <name>A0A0B1P476_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002633">
        <property type="protein sequence ID" value="KHJ31716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P476"/>
    <dbReference type="HOGENOM" id="CLU_645904_0_0_1"/>
    <dbReference type="OMA" id="CARSKKC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="47500" checksum="9B0B556BE666A535" modified="2015-03-04" version="1">MKMTISLSIRSPDIVNKLQSTEENEYDFDEEFPPLTETANSTYNIVDQNNSSPQKTSAAPLMAAIKGLLDLTNDYLQNLDKEHPGVGADFLALLADGASRAMRGERVYASLQNTSKVNTYPPKATWAQKVASDVHDLKQSKEDRRVIIRLSPNHEARKTGSFELRQKVQSVLSDKSLVSDAWFVPSGVAILAPSPTKAATLMQFKDTIEKMFGEATVERQETWKTFVIGPIPKTIRGLDGVHNTMEGPLQEELAFVRDIVPIRYMGWTRRSQNEEPYGYIRICVPESRADKFPSRLRIFGEAVSIQRIRPRSQITVCEKCFGFHATRLCARSKKCWTCGADAHNGTCQSGPRCLNCRGPHSSNDVSCPARPRRSHGILKRPTGAQLHHIRTLGGREYVKVNSQKVINLTTNKTSTTETEIVHSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D8</accession>
    <name>A0A0B1P4D8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc finger cchc-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002812">
        <property type="protein sequence ID" value="KHJ31539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D8"/>
    <dbReference type="HOGENOM" id="CLU_1062438_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="215" mass="24146" checksum="309BB5013865A3F8" modified="2015-03-04" version="1">MIVWFDKVEYEDKAIEKSVMWKCELKATEIFESGFRMMQCYNCQKYGHIAKNCSVESKCGHCAGGQNTRTCPGKQEIRYSNCSKKHKAWDPVCPVRLAAKARAVQNRTQDLGRFVTQETQAGDLDSEWQIVGSRKRRAGLSVTEIVKPFGESHTSRGPGRPRKTPVFVIPDISTTLSDLTMIASTPTVLTQNDTRTVARENETMTTDAPETEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4F8</accession>
    <name>A0A0B1P4F8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002783">
        <property type="protein sequence ID" value="KHJ31564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4F8"/>
    <dbReference type="HOGENOM" id="CLU_687342_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45672" checksum="838D0660EDF5C72D" modified="2015-03-04" version="1">MALHGDDVTSLDGNEESMMTLEKVQQATKITIFAYMNERTKEYEEYGLKGIELFEYWKADFENFDAAAYKKTTKGTRILRYFLRINSTPWPVDSYISSDNQSHKSSFVKHQSVSSAQFDKALPSVENIDLKPEKYGYQPDNSSHSRQATARGITGALVNLSRIYSQDHKYSGDGDSFDYKFGILVDLCDKTDIPEDQNFKAFSTILKGAALKHYYTSIKPNSLITTIKGLYENIRETFEGNEYKRSILTKWNNTSLKSVMEKNPEKDVELCLQFLIEDLRTTQMALQSNFHDDTSFQNKLMTACQAHPACSIACSIPASSSVALINNLRSSISTYLAVENDKNQLQINNKIGNLVDNSDKNEQFFVDRQYYSDFSIRGNKSINSRQRTPVKRCFICQKSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4S0</accession>
    <name>A0A0B1P4S0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">EV44_g2495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001538">
        <property type="protein sequence ID" value="KHJ33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4S0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4S0"/>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="OMA" id="CPLHKVR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="123"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="418" mass="46953" checksum="DE1F8B9022681D0C" modified="2015-03-04" version="1">MMSLSIKRKAVTEGVINDNKKPKLNTSITSFFSKPKASQNIVGDQTSSPSSKFDKEAWVNSLTSDQKKLLKLEIETLHESWLKELKDDLLKPSFLGLKQFLQKEKADHKTVFPPESDIYSWSRYTPLPTVKAVILGQDPYHNFSQAHGLSFSVKPPTAPPPSLRNIFIALKNDYPNNFRPPPQNTGQLTPWANQGVLLLNTCLTVRAHEANSHANRGWEAFTQRVIDIVAKRRTSGVVFLAWGTPARKRVDKVDKTRHLVLLSVHPSPLSASRGWFECGHFRKTNEWLAVRYGSGAEIDWNLDKDHAQVINKYEEKNKNVKEKCSTNQKDSTSVQETIISHISEKGSDKAGSENIISDKNTIPDENTTLDENIISDKNWDDNADVISCVNSAKEKEAAEKVMSTNTPEEDETKEISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4S1</accession>
    <name>A0A0B1P4S1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002194">
        <property type="protein sequence ID" value="KHJ32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4S1"/>
    <dbReference type="HOGENOM" id="CLU_1050510_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="30731" checksum="860C70B21A07CFCC" modified="2015-03-04" version="1">MDESNFLTLPTTIICRGEMFVKRAWPEALFPQDVQDDVYTSVKNKVVLKPEWRLVVANSEVFNKLTQIQNALQIALIPYHLWTKRVTMDMSGDFHAACVWAIGRNPTWIELLETIFTMMQRLNVLYSPFTKFSLLTPQKNESSHTFAWRLRDAFYQLSRQDRESDTTREVLKELTMTHLPRVWTLEYPHTISTDNYELTETIVQISAQVTKWSNESGISQQSNLETDNLHLPSLETSSFKTLENTPDDVFATRDGTCYNCGKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4W4</accession>
    <name>A0A0B1P4W4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002419">
        <property type="protein sequence ID" value="KHJ31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4W4"/>
    <dbReference type="HOGENOM" id="CLU_469345_0_0_1"/>
    <dbReference type="OMA" id="GMPSWTA"/>
    <dbReference type="OrthoDB" id="4157036at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="565" mass="63694" checksum="9775FD96D629FA48" modified="2015-03-04" version="1">MSINYSCSLSQKTMQLPLREIYQPRIVACEASTKQKQRENSFTLNSNSSDDLPSPHASIYEAVHISANSSEDNGHKIELINIPPRRSKSVSKGRGNDENIRDVQTNLNNRSNDIEFLYGRGTVLDTIAEQKSSTTMRTIARSKSVEDLSTSAFLRYQNSFELSDGLHRKRSFSVDDFEMTKRSYHEACIMIERKAPILSPGHEIYAQPKTPVEAPLKRPSTPPGMPSWTASQNLHIARLEESAIRNRYQRRHDLPTSKPNQHSFLSQDPSTQFRSSTSQTRGFIAPRFKPPKSTYYSLNQHPFFSACLQKARPRSRYYDNESSPEGSNIPLRRVNQENGNNNSHIRFTPSILVGNPEILSQQTQIYPENTFASRLGSQTNNLKSKSSKHTHSRAGGKNSKVKCHHSKGRRVALKKRIMSDPYLRSSQNLNTITLESDMDVASLRSVSGLSIPLSMNSTPGSSHNVANTRSISLSSSTALISSTRLPSKMDVKVMKSSKENIRLCWKCKLEDTFAKMDQIWTQASSCMCFTCCKFDTDEDHHSETVFQRFAGARSRYPHVTRGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5D1</accession>
    <name>A0A0B1P5D1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g1192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01001406">
        <property type="protein sequence ID" value="KHJ33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5D1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5D1"/>
    <dbReference type="HOGENOM" id="CLU_027974_3_0_1"/>
    <dbReference type="OMA" id="QMRDRIF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="410"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="52522" checksum="D17A51C6520B9C89" modified="2015-03-04" version="1">MPPTMQQRYGGGHNGLSQHYHSYTSHQHGSGLTPPSLNSMNANSMSSVFSVNGNALSLSSGFGNGGLGLPSGTGLASQAAQMSFNCLGMHHQHNGMGEIGGPRMTGNKNRIRDVWACNLHEEIDLLRRIAVSCPYVAMNAEFPGVVARPMGAFNGRSDYHYQCMRCNVDLINMYQLGISLFTEDGESPPPIIQSSALGMDSTEARKYGPVIHIPTTWQFHFKFSLKVDMYSEISIESSRQAGIDVSRMETDGIDPFVFGSLLMTSGLVCDEDVHWLACHGAYDLGHLTKVLSVLPLPDDETGFDTIMKKFFPSVFDIKYLIKEAIRRHQLGQLTPLDSGTNELMAKLEAKPGLDHLADCLKVKRVGPQHQAGSNSLLTGKLFFKIREQFFGGEMDEEMSGKMYGIGNPEIKNQPSNPQTNSQHYNNQESLPSSANGLPNGTPSTPNTASAGLAQTPGHSSNSGTGIGPLTPSGAGGIFGAFQYNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5V1</accession>
    <name>A0A0B1P5V1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peroxin-22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5V1"/>
    <dbReference type="HOGENOM" id="CLU_025740_0_0_1"/>
    <dbReference type="OMA" id="VAAWIWS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="415" mass="47080" checksum="CA3DD156F5E72D10" modified="2015-03-04" version="1">MSYQRQDHNARVSRRDTLSYWLPLALTVSITALGVATWIWTERRDDDELPRAPSGKKSYHGSKQHDDKFERDSSHENEGATPLPSPFYNQGYMARMSDVLRRTPSPQQIFDGASKSIVDGITAASVVVGTALGSIMEEDRNAYKDHQTWSEEVNSRKSEFHLERPSSETLNLQRSISDRVNTINTSSKSVMRKTIAIVISTSSDSGLKEEEEKFQVYASILSYLPQKIDFLKTRLFILIYAPLLKVHPLDASPSNSGLQDPTLKRNNIQSQLSFESSDKIQFSATQSTMFDSIYFEALRIVEKETMVLPFTSATGHLQILRHLKPDIVYLQESLSGINGEYISNIQTWLRQDIVLIIGDGCNSSGLADTDSEIKPIDSKEYWWKREDRVGKGRGVIVMEAFRIGDDWNKRVENKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H9</accession>
    <name>A0A0B1P6H9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative trna 2-phosphotransferase 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002219">
        <property type="protein sequence ID" value="KHJ32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H9"/>
    <dbReference type="HOGENOM" id="CLU_852584_0_0_1"/>
    <dbReference type="OMA" id="WANCEDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="35078" checksum="0688D95FEF6268D1" modified="2015-03-04" version="1">MVMDMENQELKVSSGEIMPPSPLTPNVSRHGRGKHGGSNVKNKGRGRGYSIVDEREWLISKTLARILKHNVDADQDEDQDGNDGWANCEDILAHSEILALEGTLSELETFSNSPKPKFTVKLKPGITVSEDHVSSDYLIRINHLPTTATTNTANSMLIPLNGSTSDLPKLVIYETSYANYPLILASGGIKRAGGQPYLSFKAISLIGETELPPVSADVSIYIDLPLAIEANQTILWQRTESGVIITEGDNEGMINKSLWKNVIARRADIGVLFEDGQVKREVPSNLRGKGAKLKKKLKAKGNDMNEIKALGENEMVSDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6J2</accession>
    <name>A0A0B1P6J2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001175">
        <property type="protein sequence ID" value="KHJ33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6J2"/>
    <dbReference type="HOGENOM" id="CLU_2335192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="98" mass="9928" checksum="1B0E706DC5237507" modified="2015-03-04" version="1">MLNYDDKTLARICQPRVEVGSDAGIDRERGTSGLVLTGAGAGAGAGAGAGADAGEGGFGFDIDIDRGRGIDGRVLKVSNVAVVEVDAEMFKLVVTVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6X9</accession>
    <name>A0A0B1P6X9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001620">
        <property type="protein sequence ID" value="KHJ33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6X9"/>
    <dbReference type="HOGENOM" id="CLU_118652_1_1_1"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="113" mass="12891" checksum="BFA10C78A69E375E" modified="2015-03-04" version="1">MSSNRLTYRRRNPYNTRSNKVRVVKTPGGSLRYLHIKKAGTVPKCGDCGTKLSGIPALRPRKYSQISRPKKTVQRAYGGSRCASCVRDRIVRAFLIEEQKIVKKVLKETQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z7</accession>
    <name>A0A0B1P6Z7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ph domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001878">
        <property type="protein sequence ID" value="KHJ32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Z7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Z7"/>
    <dbReference type="HOGENOM" id="CLU_067862_3_1_1"/>
    <dbReference type="OMA" id="CNFCGIR"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="200" mass="21784" checksum="6504BB7AA36A1A1A" modified="2015-03-04" version="1">MASLLAKLISKKLLRENLENKFGLEDPRFETIPATNIGGKPKKRLKALPPGISAHDGKVLTKVKRRAYRLDLCLCNCCGIRFGWSSVIGIVPGFGDALDVFMALMVLRTCQKVDGGLPKSVQAKMLINIIIDFGVGLIPFIGDIADALFRANTRNAILLEQHLRDKGIKNLEAQNLPPEPPTSVKLNQSEQRVIGGSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P723</accession>
    <name>A0A0B1P723_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ormdl family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001603">
        <property type="protein sequence ID" value="KHJ33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P723"/>
    <dbReference type="STRING" id="52586.A0A0B1P723"/>
    <dbReference type="HOGENOM" id="CLU_072117_2_0_1"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="180" mass="20770" checksum="896AE26A22B31636" modified="2015-03-04" version="1">MIDFKVGRKRRSSSLIYHEPPETIEHMSDQAALPNLNANWVNAKGAWTIHLVLIICLKVLFDIIPGISQETSWTLTNISYMFGSFLMFHWVRGVPFEFNAGAYDNLNMWEQIDNGAQYTPAKKFLLSVPILLFLLSTHYTHYDLMYFTINFLAVLGVVIPKLPYSHRTRVGLFSRSPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P738</accession>
    <name>A0A0B1P738_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ubiquitin-conjugating enzyme protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P738"/>
    <dbReference type="HOGENOM" id="CLU_439534_0_0_1"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="622" mass="69934" checksum="787A8CC0D289F63B" modified="2015-03-04" version="1">MASLPGKSTCLELYRPVTTRPEPLKITKAIQAVSNSSTFEKTDSKECGYSSPFTQRKWSPSLAYDWPVTVRKRRCATQNGRPSSFESKNKTPISLEEVMRAQRAQLNLRNQRNNEIPLVVSSGELNATQKKLKPNLRAISNVPFLKSGSHQQSSQIEINRYPVHCYRKNTQQRNSLDVHKSFELKAPKSNNFKKSYSRSKENMFPTKPVCGQLNCNQTSFINSNFQSASYYRRSNSCATRDSYSSNDSNLGESYDVRRTLPSIKRFFSRSLSSVSIKTKNQYSSKYTLFPEIRITPEAPCIDLAENLIWVAVEVTGVLREVQSSGKEFNKLRQDQESSVFRTQDVKKYGCLGSVHIHIKAGRGCLISDIIGNNHNSLTIGVNESHLVLVKIRIRAASTLLYSTESLGNLIEELQNDHGKIQSKYISVRVSFTHSDFNGIKFPNICIPGVNPQKTQVQTEVTGIISRVGPNSACSPDDKHLTIDIPRSKNPVLDLIETRLPASEAREASRLIVSSSKNLLPIKRCVDTEESNFLNESIKTSESDFNLDNFPLPPSNSSALDVTSQHDHYLDPHCDIWAQFDKVSPLAEARNLSNFNFSRKFGEKDARLNSGSTSDPSFENRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7L6</accession>
    <name>A0A0B1P7L6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5708</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01000979">
        <property type="protein sequence ID" value="KHJ34243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7L6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7L6"/>
    <dbReference type="HOGENOM" id="CLU_006103_1_1_1"/>
    <dbReference type="OMA" id="ASANTHK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="13">
        <location>
            <begin position="199"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="14">
        <location>
            <begin position="798"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="902" mass="101501" checksum="CA6C55737367D2B0" modified="2015-03-04" version="1">MQTRVSGSGIEAQKNTNSILVPEECSNNLNVVCQKDQDLCLLHSNKKSANRGSLYELDPRRSIVTSRRPSANGKYIDSPDGDMDSQNESSILIGVTLKKPARANNMADNRHDVSIRTRLRSLWSISPLTLITTSAGLMILIFILHSFVTRQLDTKGCRMSYMRPSFVKLSDFDTEHTNFASKYSMYLYREGGIDHDEKVKGVPVLFIPGNAGSYKQVRPIAAEGASFYHEVLRFDSSAKSAGVRQLDFFTVDFNEDITAFHGRTLLDQAEYLNEAISFILSLYHDPHRSERDLDLPDPTSVIILGHSMGGIVARTMLIMPNYQTNSINTIITMSAPHARPPVSFDSEIVTTYQRINKYWRDAYSQKWANNNPLWHVTLISIAGGGLDTVVPSDYASLDSLVPDTHGFTVFTSTVPNVWTGMDHQAILWCDQFRNIVVRSLYDIIDVNRPAQTKPRADRMRSFKKWYLTGMEKSTEKTFAQNHATTLITLEHKTNTILPQGDKLVIRGLGQNQGPRTHLLPIPPLGGPGENRFTLLTDQKLDKENGSEKVEVLFCSIFGTHSGRSSTLFSVDVISPGVAATRLACKNSVSDVILIPASTQMSRYPFYLDGEEKIEPFSYLQYELQDINEHQFVAVIDKAIRPTSGWIVAEFSHDKQSDFTYSLSLQNLLIFGMELSLPPTRPLVTEVKIPALSSSLLSYTLEINNQKLPEKTELFAPILRQYISEPHESKFFVNFRKADINLHGVSPFIPPSLSKKKSYDDGLSFQFWTDPTYGSSLSISLKLDFLGSLGKLYMRYRTVFAAFPLLVVALVLRKQFRVYDETGVFMTFSASLDLCLRQSLPLVLMAITLFSLSSMKVNSLFNQSSSGSLGWKVNETEPQIDFTRNDTFMGSQDPFFWFMIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7N0</accession>
    <name>A0A0B1P7N0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001702">
        <property type="protein sequence ID" value="KHJ32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7N0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7N0"/>
    <dbReference type="HOGENOM" id="CLU_039318_0_0_1"/>
    <dbReference type="OMA" id="EHVNPPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="507" mass="57912" checksum="F942E8696031EA74" modified="2015-03-04" version="1">MFEQKLNEKVQLSIKSFYKREVQTEQQTSSHILCTKVGDGFTEAELVNSLDPLRRNWDPDRNYIRLSINQIRAGPKHISFSGRIVNMKTYFGVCTQQQKANGWHYLIIKDDTGAIFVGLFVTLWTAFISETLHGHIHGQQERQHQFLTRTKNIINVNMFPGRVASDHILIQHETDSSDSRKSSCRPFEYKIKHDLHLLVPLDSYLNSGYDVKGIKILVVVKNITSSRKIKRKNGDEVDEVTNVGLMDNTAECSLTLWNDLIPSAHSWHPKETILLITDPGFNHQCSTTNQNRGSLQILQNTMIEIDPTFENALWLRQWAKRKARQEAVTWESTENKWKFESSFCGETLRIFTLAELDNRVRSGWSYSFSGFINIIIRNMNIYRLHLRNKLMCGQCCGNLLFSNESVLECGVCGKLISLLPNASVVGQLLDETGCIDGGSLQWSPSAWENLFGRPVEAIANLSANDCDTFEQRLCFLRIYLHVGWREAHVTSDKTTKIAKLSVLGVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Q9</accession>
    <name>A0A0B1P7Q9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000734">
        <property type="protein sequence ID" value="KHJ34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Q9"/>
    <dbReference type="HOGENOM" id="CLU_013695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="283"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="567" mass="65924" checksum="B80BE04A80295F6F" modified="2015-03-04" version="1">MGDETQFCHTSTASLRLLVPTTQPLLANLRIDAKAIGTEEERVWYGSGRLTDTAFNRIHPWIEYAKGSRSFTVEEFLNRLDKAFVDPEKITKAIDKLNSIRQGNRDFREFLQDFEQTLLEAQAWGWTEEAKKSYLRADLNRDLTDRLVSQPEPHKYDDFVAQIPTISDKLEAIKAWDHRRGLKRHILQVSGAEESKAFSDQWTGSQPRLSDLAVKLPVEYHDFLDIFDHKKADFLPPLRGQGIGHTIEIEKIDGQEVKVPWGPTYSISRDELLVLHKTLTELLDKLFIRVSNSPAAAPVLFVKKPSGSLRFCVDYRELNRLKRKDRYPLPFIYETLWNISKAKWFTKLDVIAAFHKIRIAEGDEWKTAFRTRYGLYEWPVTPFGLANALITFQKYINWVLRDYLDNFCSAYVDDILIYSESKSEHKVHVQKVLRSLKEAGLQLDIVKCEFETQRIKYLGFIIEAEKGLQMDPEKIKAIETWEAPTSVKGVRGFLGLANFYRRFIHNFADLVRPLTSLTRKDCKFHRNSEAQSAFQNLKRIFIKAPALGQFDYDGQSRIRNRFLWLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7R0</accession>
    <name>A0A0B1P7R0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative related to rna-splicing regulatory protein phosphatase cyt-mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001480">
        <property type="protein sequence ID" value="KHJ33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7R0"/>
    <dbReference type="STRING" id="52586.A0A0B1P7R0"/>
    <dbReference type="HOGENOM" id="CLU_002512_0_0_1"/>
    <dbReference type="OMA" id="WPYFFPR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="433"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="943" mass="106651" checksum="8A7971515B67BCC5" modified="2015-03-04" version="1">MNTNPIISSQTLENSFNPVTHPFVTHLSVKSTSDEVTEEDILPTQELEDGLEGIKRDFLVPGDLVDLICGGNKNELAIFIQRLDLQAQYYTISGRWLHQLGTNVNIYFPNFVDPSELEELKRYLPREDVPANQEDALHGFEKVLPRTIGGPLLKKMKNFWSQANAIYETTASKLDESYQIVAHPTEFKYATISELADKILSGIIPRKKDGKFPDPALYALHRRIYCESPGFIPANLRKTRGQTQYEILPLNLAEEMSRVINYVRKFNRFNLSRGKSEKPTEIQAFAKKANGLIRRSRQNRDFTVYGNIGPYKGKQVDDFKNTQREKFLGTNLEIVRFLEIWTGLNTLGATIGPTYDSAGSTILRAIGLYNNPDVRLNKQTGWTCLKEIGAITPWQTVAQYGIRAPNASCRLSLSPRLTSSQTDCSIDKMKDYRIDLKDINTFCIDDADALELDDGLSLEATDSLDEFWVHIHVADPTSILDPHGKESKYAQTRGNTVFLPGCKVPMLDHDIVMNHMSLAEGKLCLTISAKLNYKGELLDSKINPRILGKVICITPKTFAEVNNNSDRKTPISFSVGPRIIAQIPSRILAGKDQLSEKQQSELQILNKLGEARTLLLQKKGATFSLIEHDSLKIYFMNSNHQVISNNCFFPKTDPTIEVRLPRSYQDSIIGHPVTKNSCGTAMSAFMQLAGQIAADWCRKRNIPIPYRIALSQVSSQKLAEFHHLKILPFLEKEEIVPNSLISEYLALIGPVHLSAEPAPHPALAMEAYAKVTSPLRRFLDMVVHWQINAAIKQEAESNQTLVVGKGQNYLPFSKSWINSILPHMTRLERWAKYYENCSIQEWKCQFLLRSWKYSQSKLPSPLVFLAKRTVLGSRNSVFGELTCIAMKALMEIPGFMDFKDIKEGDLFEVEIIDLNIHSQKVTLKAIRKLNLEDIPRLDQEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7W8</accession>
    <name>A0A0B1P7W8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000942">
        <property type="protein sequence ID" value="KHJ34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7W8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7W8"/>
    <dbReference type="HOGENOM" id="CLU_002874_0_0_1"/>
    <dbReference type="OMA" id="QTWRIVK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134209" checksum="1B894C2350B2D159" modified="2015-03-04" version="1">MMNTRGKLMRLLGQHSGNTTPGGGIDTTLSRCPSASHSLAFCAGKDILCLDRSPDGQRVVIAGNGVFKVVKVEMLDIREEIDLRSIIWALNSNCNTAIHTSGINDNLAIVAVKWLHSVLNSIIVAASANGVITAYDLNRISEGPEIARVVAHEREIYKIAISPYKPHWLLSASRDGSVKSWNIRLPGDNSSSAYFRQLHTFKTTSDVLDVEWSPKDGMAFACCTEQGQILVWDLRDSTKPQLRINAHFGQCYSIAWHPNGEYIASGGQDQLCHVWSIPKDGRKVQKPLYAIETRGPIAYVLWRPALWSTTAHAKRAAQITVSYQDDRKLDSLVEIWDLARPTMPFKQLPYISRAEQSESSRRFNDKGWDTAPVGIIWNNRNILWTISNSVGTTDSGQSTRREGWLIQSNLSYVPNSIEQRSLSNLKFSPTGDVLMILEQRQAIRQRRPTVVSPEISPNFPQSCSPSSLQDLSESEEEIIGKFLGTKINRGLQIKIKDRSNQISTTPPKPTIANEEVMTLEASIKLTGVYKPQQVMAIGHAPSAMDCSEYQFYCNCYLNHLDKVPKIDEIPNVRIPSILEDFAKTAENLRNNRLAQTWRILALSMGALLARRAEYHRSIRQQSQEKIPPKIENDDIDTIKNDVSLTAKQLNFNEITSEILLPRETETNTQTSLNDDFSKEQISEEKMLLPKSPKKPSKDIINSPKEVCRTSDSSIPSRVKHNHPNYVSDHDSFTDTDQLFAPIKNLANLSMDSSEAEELFPLKARTEINLLSEEKCSSLEFCDNNDPSPKKMEIENFRIDFEGDKDKSRLLAIKKKNMDKFSLAHGNFLDEEDKKISQEVNLMHEVKDESDLSSSLESEIRYSIDESWTPDDQNLKKAHTKTLLSSLSNFGIHRNSATKFSSKGSSSSDTLSHPESSRLLSKDESSFIPEDFLYAKNDPPFTLSILDPSSILQRLINFYTATTSTPLHLIPILLLLVPYLSPDTISHLHACQIISDVHARLTLLNLNMEATLLRNLCVPRYPEVFAESQQNTHVDFICTECKKIFVCDPYKPKAQWKCLKCRSYMAPCPICEQREYIPEEAQFEWKTDFQTEEDLDYDTALTLGTWWYCTVCAHGGHVACMLKWHAPSKLGDEMGTLHSNGVCPVVGCIHPCLSGSWRDELIREREAIAERKLAKKLITNHMSEATVSKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y2</accession>
    <name>A0A0B1P7Y2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fumarylacetoacetate hydrolase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001835">
        <property type="protein sequence ID" value="KHJ32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y2"/>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="27305" checksum="F27FBFD3371F13BF" modified="2015-03-04" version="1">MSLTFRQRYSIRAVSQSLRCGASKVVCIGRNYADHVAELNSSKPKQPFFFLKPPSSILLPGEGPVIRPRGVNLHYEVELALIIGKKVKDLEESNTQCAFDAIQSYALCIDMTARNIQDEAKKKGLPWSIAKGFDTFLPMSNAIPKSTIPDPHNIELYLRVNDEPKPRQQDNTNLFLFKIPQILASVSKVFTLEVGDIVITGTPKGVGSVVPGDTISAGIRSHGNELEDAKIRVKIVESSSSYNYKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8F6</accession>
    <name>A0A0B1P8F6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000827">
        <property type="protein sequence ID" value="KHJ34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8F6"/>
    <dbReference type="STRING" id="52586.A0A0B1P8F6"/>
    <dbReference type="HOGENOM" id="CLU_715684_0_0_1"/>
    <dbReference type="OMA" id="ICISNMI"/>
    <dbReference type="OrthoDB" id="4793227at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="398" mass="43995" checksum="57EA9ADA8F863096" modified="2015-03-04" version="1">MAATVAVIGDILKTTIAGHGFLKSITGGGPGPDYYKIRMEIGNNKDASGNPPSIILTDFSNTQHFSVFQGTSKKDNEQCRNNKDLPIGDFDGRDLSLFKGLKNGEAPLNTFKTGNGFNLKTVDLQGGGNAICISNMIFKGSDTQARRDEIFLPIGDLGFLCGKSWNWGTILDDTRQHCIWLDGQPDADNKPMQSISLDMERIAGIFNVGKEQKLKDLDLKTACSLFRDNTGEIPNRNACKTSYKRDIMSKDVTIDTVPLVNITSSEFTEGKSTLNLDGFYGAGFVTSDNKFFQSETRTFKEFSILNDTDPSNVASTSSTETSKYIKTRDLLRRGRRRKSKARKFRKISTGIKPSKKNSKRKKKSQKRETTSNVIKVQTCKATEDGVAPNCTIEETIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8F8</accession>
    <name>A0A0B1P8F8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001322">
        <property type="protein sequence ID" value="KHJ33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8F8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8F8"/>
    <dbReference type="HOGENOM" id="CLU_1094964_0_0_1"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="254" mass="29271" checksum="2E85B6E4A2C41EC5" modified="2015-03-04" version="1">MPSIIEKSLLMRPRPKISPYASPLIEIEFNETKNVYSVPRVLLQGQSWVSDDVDSYTCPYSEEVGHVLIHFLFTGEYQILEIDESKINEDKTMAELRIAVRVILVLGDWKCRGIQELVQSEIEFLSNSIHVFDVVRLVDEEFRGRTVKYSFEQEKWLKNFLVKRLNVAFEKNMTDFENFSLFDKLHNTDLIKFLAKNLLQTYYSRIPTSDENSPDIHVTESHEAGSTSAVTSPIPKNMSSDDLVKETENADPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8T1</accession>
    <name>A0A0B1P8T1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g5017</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000761">
        <property type="protein sequence ID" value="KHJ34663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8T1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8T1"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140572">
        <property type="term" value="P:vacuole fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000022">
        <property type="entry name" value="Dynamin-like GTPase Dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="699"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="633"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="787" mass="87998" checksum="974BE4067BF0DEDF" modified="2015-03-04" version="1">MASLGEDLLGIVNKLQDLVFNTIGNDSLDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLINILPDEDAPDAIVSTQAEWAEFHHIPNRRFTEFHDVKREIENETARIAGNNKGINRHPINLKIYSPHVLSLTLVDLPGLTKVPIGDQPTDIEKQTRNLISEYIAKPNSIILAVSPANVDIVNSEALKLARHVDPLGRRTIGVLTKIDLMDHGTNAMDILSGRVYPLKLGFIGVVNRSQQDIQGNKSLEEALKAESSFFKHHPAYRNIASRCGTQFLAKSLNTTLMAHIRERLPDIKARLNTLMGQTQQELAGYGDMHFSGKEHRGSLVLQLMTRFASSFISSIDGTSTDISTKELCGGARIYYIFNSVFGNSLESIDPTTNLSALDIRTAIRNSTGPRPSLFVPELAFDLLVKPQIKLLEIPSQRCVELVYEELIKICHTCGSTELTRFPRLQAKLIEVVSDLLRERLGPASSYVESLISIQRAYINTNHPNFLGAAAAMSNVVTNKQDRERKKLIQEERERREKKRLKEYASNENSIPEEIEEEEEAEKKSSRKPIHISSRSLSPKIRDNSTSNGMLASINGVNGIAGGSRDSFLNYFFGKDGTPGGMATPSMHNANLGRNVSQSTEPIFSQSMRRPEERISHGSLTQQQRDDEVNGKPPREYEYNPSFGNNSEPVLTDREAMETELIRALISSYFNIVRESIADQVPKAVMHLLVNHSKDVVQNRLVSELYREEMFEELLYEDDAVKKEREKCEKLLRTYREAAKIIGEVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Y5</accession>
    <name>A0A0B1P8Y5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component PIG-T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001455">
        <property type="protein sequence ID" value="KHJ33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Y5"/>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="OMA" id="EVRVCWL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059438" description="GPI transamidase component PIG-T" evidence="2">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27447" checksum="1DA889A8EC0B14F0" modified="2015-03-04" version="1">MIIIYILTLMAYKGVFANTEKVIFEASKSNGVLHGVDYHDFWNLPLEKLSPQFGKLKTKIFAEFPTLNSTYGRESWFLLHGISQRHRYEARICWTATQPTSFQLVTYDFVEVLQSLDLKFSLEKYSMSRKLGSSGLNTIGNKYFQDLKVSELNASSSLLLQIFAAADYYTTNASLMQYPQPVQVEIILDPYFLNIVPKSLIPTIAYILILVVGGWSFSIFLNHWAQSLICNINIEKKTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P900</accession>
    <name>A0A0B1P900_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyruvate dehydrogenase dihydrolipoamide acetyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001435">
        <property type="protein sequence ID" value="KHJ33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P900"/>
    <dbReference type="STRING" id="52586.A0A0B1P900"/>
    <dbReference type="HOGENOM" id="CLU_100298_0_0_1"/>
    <dbReference type="OMA" id="LQNKFPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039454">
        <property type="entry name" value="OM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402:SF1">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20117" checksum="075C741E72109606" modified="2015-03-04" version="1">MSYASVAGSGPEQTFEEASILYNKRAPAPPEIENKEPVAQVSSVDVDITPVHTVPTEFKFQSVDAKTQENYLHEEHQSDEIQAKVTEEKHEKAAQSCEKKSIAKRGKSNNHVNGNDKDHIPVFNIVAVIALCSGLSFGLYRTYIAGQLNWKVLGIWTGIAGAFAIANFNLTLFFESAFRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B6</accession>
    <name>A0A0B1P9B6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000677">
        <property type="protein sequence ID" value="KHJ34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9B6"/>
    <dbReference type="HOGENOM" id="CLU_924999_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34026" checksum="7CFABBFBD2602468" modified="2015-03-04" version="1">MTIKPSEFLEYESEYYIEPSSRESQIEVDSRNSVEMANDEVIKLENIAEFQSGDGVKWLKMLKHELGAQRKPLTPENILYCVDLKFTEDADRWIQQTAFVRRMLEDTATATEADLIHFEEAFKSRFLNMITVGEFDVHAKLVKLQQNSNESLSEYSPRTISLLHEFGVKDQVAGVELSAAEAGTLNSIKSKFIYGLSDAELRLEAVNLQALLSNSLASCISIVNTAVKMLEQKRKLQEEVAVQQRLKTLDLFDKQARIAGYNNLLSYAHSLDRHSIINSVQIQPSATKASITHVEQQAHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9B8</accession>
    <name>A0A0B1P9B8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9B8"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="290" mass="32084" checksum="6597D9B11CC26CA4" modified="2015-03-04" version="1">MDSRQILKPVAPSKRPGTERPTQHRKDKFEAEKAFLPKELADVIAFRQRRGRAWHAHLMICTTIISSVESTPASFKNEIEKEEVEVLKAYLRLAIANFAAVDTSPTPQSNGLGKDKNVLKKVAVATSRIMESAASTEGNKQEAHKLPKTPHIRQDTCATVARNGQKKVRVILSNKTQVAPVNQRSENKEISSSTPVDKRLFARISKEYELLKLPPAGLREVIVKKLSISPTLIGKIKPVHSGFVLCPCNTEACEAILTTADCFFIKGAKLEQATNWTPVILSTVLSVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9K6</accession>
    <name>A0A0B1P9K6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001088">
        <property type="protein sequence ID" value="KHJ34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1983220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="126" mass="14120" checksum="98961CD38209DA85" modified="2015-03-04" version="1">MSILVFAKFRLTSVITFKIMKVSRAQSSIAIQIRSEHLGLNSYLHRRGVPGVENPKCQCGYPSQNAKHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVQKKKKMPRVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W4</accession>
    <name>A0A0B1P9W4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000558">
        <property type="protein sequence ID" value="KHJ35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9W4"/>
    <dbReference type="HOGENOM" id="CLU_015147_1_0_1"/>
    <dbReference type="OMA" id="KYSWMTG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="642" mass="69864" checksum="E74113F240D7EC24" modified="2015-03-04" version="1">MVQQPQPQPRLAPPQGLGSPPLGGTSSIIQPSIGGISNKRPRLSHNDSTQPNSPYTSQSPYSHSPTLLQSTQSPHFTNVSIPSQAYTTPYTNGHSNTNISHSQTQINHQNSYQPSSLSLSNHLNFPQQLNYNGNFSMSGQTSSNMAPPSRPAEKPKDESVDVMDVLGGTGVDLREEEQYTFQLYNDSFNSMLSGSHSGNISLSHSFTQFPPHDEASFFGSGPANVIGEKVDSISQDEYIQKAADIAWREAARNLHISRQRELDNPFLHVHLVHAKLRKLASEHGIELNTDSKGMMGIMTRPHAFPERDVRAQTAVGPDGIMVTTSGNFLPFDSMLVDQLALLSIATKHRLRGLVEDAVKLAKGRRTGSHGIIAEEWKDIAAPFDFEGSSIVRNDSVRMGWKSSVSPKSNSLKRPHPKDEKLVTPVMSNNNNLIGSGKITNEVIIALRRQALKEREAEEGRLKRRLERASGTSTSSRQASIVSTPGSVAPETVEKMTTKKDLKKKAEARVSEAASHAAANVTTAQFLGSGSGLFGKKKKYSWMNPTPVSGGSNSFAGGSSNTQRKTGSGHSVSTTIVSSGISNISPVERLTVEGSRRLGTWREDREKGAGVQLRDWITVLENDGHEKKALQHAYTKLDGSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Z2</accession>
    <name>A0A0B1P9Z2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative duf974 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001255">
        <property type="protein sequence ID" value="KHJ33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Z2"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Z2"/>
    <dbReference type="HOGENOM" id="CLU_027041_1_1_1"/>
    <dbReference type="OMA" id="YLCVHNG"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="3">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="35318" checksum="D1D972F06BF37371" modified="2015-03-04" version="1">MTQVRSPAALDIIREPHSVSLKVLRLSRPSLSIQQPLPISSEPALSSASYAYPIQNSHNDGFILSPLLTLPPAFGYAYVGEVFSCTLCANNEILPGNISEKSINAVHIEAEIKTPNSGAPIKLSLSPSSSKSEKTLEDKDVQTDGINLAPGQSLQKIVQVELKEEGNHVLTVSVTYSENFATSGRVRNFRKLYQFVCKNCLSVRSKITAIPSKSYKTWALEAQLENCGEENIILQNVIFNDQKGFRSKSLNLNFIKQADVHENPKLMPGDVQQVCFLIEEVDEKPEIISGKLIFGTMSVYWRGTMGSKGHLTTDPLGIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA08</accession>
    <name>A0A0B1PA08_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000536">
        <property type="protein sequence ID" value="KHJ35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA08"/>
    <dbReference type="STRING" id="52586.A0A0B1PA08"/>
    <dbReference type="HOGENOM" id="CLU_011759_3_0_1"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="56"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="421"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="558" mass="65022" checksum="5CAB927884449BB1" modified="2015-03-04" version="1">MQSGRKALLADRSSHVKEILAPRRDSYKRVSKPNKFHDSVSKSRDPYLSRTNSNIEDEQTRKWVSEEDNFVLKQSKKKAEIRAREGRAKPIDWLAVILQVIDPDRDLLDDDDDHNFQHEGMNPESVFEGLDDTQLTELSKDISSYITLEKNKANLEYWKMMRTICEDLRQKLNPLNTEGRAVGSVAADVDKLLRPKTFEQLEILEKQIKAKLQSNVSLDVDYWDYLLRNLLLWKAKAKLKEVYQTVIDSRLNTLKKQHQEDAKRARIRMQEILSNLNQNSSKNIEHNFTGLSSESQQPLFLYSEAYDPSPSLKKDSHEKSSGALDETIFLKKVVLDRQRIIKSGLFPPRQHTCEKNSTSNFQTTLTNNIPSGSQRNLNPVNDDVSQTTKALYEREAARGIDEDEEIFTGEEAVTTVAKPQWADKYRPRKPRYFNRVQMGYEWNKYNQTHYDHDNPPPKVVQGYKFNIFYPDLIDKSKAPTFKIIRENGRKKGMSFAPAGEEDTCLIRFIAGPPYEDIAFRIVDKEWDYSAKRDRGFRSSFDKGILQLHFQYKKIYYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT1</accession>
    <name>A0A0B1PAT1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000859">
        <property type="protein sequence ID" value="KHJ34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAT1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAT1"/>
    <dbReference type="HOGENOM" id="CLU_000690_2_2_1"/>
    <dbReference type="OMA" id="ILYWAHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="876" mass="100801" checksum="ED99A86AD0BC599C" modified="2015-03-04" version="1">MSFVKNLKSNLDHFADDLRKPLQDIRDKVEQEIKHHGKFKEHESSAVASHHENRFHSFASRREHNSAKWYVDGCGYMWAVSVALEEARESIWILDWWLSPELYLRRPPSLNENYRLDRMLIAAANRGVKINIIVYKEVTAVLTLCSSHTKEALELHPNIAVFRHPDHKPVTLPSEIVSTISNFSFNPGNLARVPRDTLKGLYGVNEEVVLYWAHHEKLCLIDGKVAFMGGLDLCYGRWDTNDHPIADAHPTDLNKILFPGQDFNNARVYDFENVKDYMHNKLDRNKSSRMGWSDVSICLAGPVVEDLKAHFTQRWNYIFNNKYRARKDPRYNALIFESPENQHCSDGGNENPSNQYNDYNYNRSVEDQGFNLDFSNGSEMFSRFRSKFPVSRKQVVMPHLDKSGSKAIQLVRSCSEWSHGVSTEHSINNAYIDIINQSQHFVYIENQFFITATDDDQRPVRNKIGAAIVERVVRAYREGQNYKIIILIPSVPAFAGDLSADDALGTRAIMEFQYHSICRNGHSILEKIERAGVPDAKRYIRFYNLRNFDRINTVENSVSYDGMRCENIRREECGISGAGYDRCGENQSLSGYYNQRYEGNQEPSCGTMNKNDYDSISSCYMQSPLSVNQIPWNGNSEEEFDAFVSEELYIHSKLLIADDRIVICGSANLNDRSQLGSHDSEIAVVIEDPTPIESFMDGRPYQASAFACSLRRQIFRKHLGLLPVQDPRYPTANFFPIDKSPNEYDWNSPADQLVSDPLGENFTELWDRTARINTETFSRAFHMVPSDNCTNWEQYQEWYGRFFLSPSNKEDKVQVPPKYQYGHLVKEEFPGGVQEAKEWLSRIRGSLIEMPLNFMNKVDFAVAGVKLNALTMEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB26</accession>
    <name>A0A0B1PB26_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="JNVN01001205">
        <property type="protein sequence ID" value="KHJ33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB26"/>
    <dbReference type="STRING" id="52586.A0A0B1PB26"/>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="161"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="550" mass="61835" checksum="5D9425507087B338" modified="2015-03-04" version="1">MTVGSSPLWITNNVSFTYHPGSSTYFSRISKINSLIIINEAIARTRKNIFLQNFVPWKLHPRNTISEFEPDAHTSRIYISQVIITQTDTDNETAFRPLAGQVDESYTISISDNGTSEITAASYHGVLYALESFSQLFYQHSSGTGFYTNLAPVKIVDNPKFPHRGLNLDVARSWFPVKSILNMIDALAINKFNRLHLHITDSQSWPLEIQSMPELAEKGAYMTGLSYSANDLTRIHDHGLRRGVEVILEVDMPGHTTSIGYAYPELIAGFAATPWYTYCAEPPCGSLKLNSPAVTSFVEKMLADIIPRVSPYSAYFHTGGDEVNKNVYLLDETVQSNDTSILTPLLQNFVSRNHDQLRKSGITPIVWEEMALDWNLTLGSDVIVQVWLSSESIAKVTSKGLKVLAGDYKNWYLDCGLGQWLNIDNGKSFQKYYPFVDYCAPHKNWRLIYAYDPLSGIPEEQHNLVLGGEVHIWAEQVDPVNLETMVWPRAAAAGEVLWSGRQDVNGQNRSQIEAAPRLAEWRERMVHRGISANPIQMIYCTQADGKECSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB78</accession>
    <name>A0A0B1PB78_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pre-mrna-splicing factor cwc26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000798">
        <property type="protein sequence ID" value="KHJ34600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB78"/>
    <dbReference type="STRING" id="52586.A0A0B1PB78"/>
    <dbReference type="HOGENOM" id="CLU_024195_0_0_1"/>
    <dbReference type="OMA" id="GDVQRQE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="37377" checksum="FE4C1BBE847A3060" modified="2015-03-04" version="1">MSLSSYLASKYLTVEPKISSGKKRKRNEKNSTANGLIIADDDILGWSKEHSSLRSHDVDKPLIVNQKSLEIQKVKKNTWKKVGAVLTNSNPDDQDADEAEKIIALTTAEKLATQNDNDQKPILVEEKITKMENGTHAGLQSAKEVAKQFEQRKQEEAASWKAEERSKKSSKKEETIYRDATGRRIDLVIRRQEAQREAALKAAKEREKLEELKGDVQRAEKIKLREELDDAKFMPLSRSINDEEMNKELREKDRWNDPAAKFMSQGMKAKNSKPLYVGAAAPNRYKIRPGYRWDGVDRGNGWEAKRFNALNTAARNKELSYSWQTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBG8</accession>
    <name>A0A0B1PBG8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000334">
        <property type="protein sequence ID" value="KHJ35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBG8"/>
    <dbReference type="STRING" id="52586.A0A0B1PBG8"/>
    <dbReference type="HOGENOM" id="CLU_622864_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="51054" checksum="E21347F7621B9024" modified="2015-03-04" version="1">MPVYRGIRLKIASPFDFQAYPEYPHPESSQFTYRSLNSQRVSEEFLVPNISSESKADSVLGRQPMASVYIQSIRGSHFWLRYNFEGSVEDKIQIYYLKLVVNGKCMKSWSVNARKEPEGQIKQFLYVPTRTWSRIQEKFSWDSKKKKIEYFRNSDKRASYPIKFNGLIEVIISLVPDRRNRKHRLPLLSEFKIPVHQDTFLGNDVLASSQVRSYLNNHPKSPKNEQFALFKFYCRDWDFIKNLKTMSSYNISQENSYLSSSTYELFHLAKTQTKGQEIDSFKNSLYRSDWEKNKSYEKSMRDSKTIIFPYLRKSPSSTNLRQTSYDAQVCKLSTKCYMVYSGVVHSNATIFDSETDIESIESKDSIGSEYFQSNHLISHIIPPQNSSTDLSSQHSRNTSSASNSFSITSSLISYEDKNFTFPELVEIGTAAVKLITDRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBH3</accession>
    <name>A0A0B1PBH3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative deacetylase complex subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000333">
        <property type="protein sequence ID" value="KHJ35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBH3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBH3"/>
    <dbReference type="HOGENOM" id="CLU_031130_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="58593" checksum="EB300559F38ED604" modified="2015-03-04" version="1">MSPSPHGSPILGPRRLERQLSSPPVSQPHVPQSNRDRKRSLIRDTFAAMEEGFLANKDSYYRINLQKIQIDINLIAAAETHGNCLLPNDPTEIEALVRESIQQNRMTQTAPESLIGAGRDYAEFAKECNDAMEERDTALAALHRDVTVKMTEIQSTYNYHQKLAYNEHNALRTTLRDRLINSVTNKKARLFKEKEIDINDNSALLLHPSQFGIANPSSPGGIHGKRATRNRRDIDETKNFPEIYKRKRKTFQCDDSPISARQRYESRSRVPSWLREKNNLMATQIDSPLYSIEKLFTEKELAMTYNNAALAAYSYIVRHDETESSQIHPSADPLLDKKPKLDTKLENEEKDSSVLNGVSSERKQPNSTKSSRDFYTSGFGIDALNDVNVDSNFQLLVRQTPKLPPISQSGFRNCLNKNEGNNSPASLSHEDITVELDLMRRARQLNDQKGLGYNLQADDKILGLLKEVVNPKGLKGRERWIASENRENLYISQKSGKTRERDPTEGSDSVTKKNSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT1</accession>
    <name>A0A0B1PBT1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pre-mrna-processing factor 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000894">
        <property type="protein sequence ID" value="KHJ34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT1"/>
    <dbReference type="HOGENOM" id="CLU_2108384_0_0_1"/>
    <dbReference type="OMA" id="RENDTMM"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13681" checksum="7ED443C3A69F5040" modified="2015-03-04" version="1">MSTLADQLLQDFEDSDPEDEDNRQAQESLSKDGVSSDSNGIIFHDVSRESMELDDDEEADDDEDQVMSGVETSSLNVQDEDNMKANVEKMELGAVDDVRSVARKMKKIEPVLEKVYISISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU2</accession>
    <name>A0A0B1PBU2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU2"/>
    <dbReference type="HOGENOM" id="CLU_078577_0_0_1"/>
    <dbReference type="OMA" id="IPKSECV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="29700" checksum="5B05E4AB58A4CEC9" modified="2015-03-04" version="1">MAPKETPLALSLLLRAHSPETALLIYTERVLHRPLHLAPNDNFLNSQQTRRLKRIRKRLNRVKDPRRPKPLSSRHARSLNIYTIPESAKKYTIYVPLNRLWIAYIQEILWDNKGFSPVNNINAAKLCSADFHGAELEVVRSRCVSRVGVKGIVVKDSKSIFELITAEDQVKIIPKEGTIFRFQLPIPDISQSYFDTESKKKFTSSINSTESQVETSKPDTPKALEKKNVVFELHGDQFLYRATDRANRKFKPHFLPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBY3</accession>
    <name>A0A0B1PBY3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g2650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000663">
        <property type="protein sequence ID" value="KHJ34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBY3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBY3"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="OMA" id="RQWYIRN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000010">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000008">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="127"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="794"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122824" checksum="214E85F8F12FAB91" modified="2015-03-04" version="1">MASNITSIGDNAEAKVNKLPSSLPVEAKATMTGQTEKKIKSEKELEKERKRAEKQAKFEQKKAKSALQFSASDSKTKEKKALAQKKTEEEVLPTYKEETKTGEKKLIKPFSDPYFKAYNPHAVESAWYSWWEKEGFFKPEFTIDGKVKPAGSFIIVEPPPNVTGNLHMGHALGTALQDVMIRWNRMQGKTTLWLPGCDHAGISTQSVVENMLWRREQKTRHDLGRPKFVETVWQWKNDYHQRINNVLRRMGGSFDWTREAFTMDENFTAAVTETFVSLHEDGIIYRANRLVNWCTKLNTALSNLEVESKELPGRTLLNVPGYDKKIEFGVIVHFQYPIEGTDQMIEVATTRIETMLGDTAIAVHPDDERYKCLVGKRAVHPFIPNRYLPIISDTYVEKEFGSGAVKITPAHDANDYALGERHNLEFINIFTDDGKMNDNAGPYVGQKRFDVRYKIQDDLKKLGLFVCKKDNPMTVPMCFKSKDIIEPLMKPQWWMKMKDMAAAALDVVKDGQIKILPENAEKSYLRWMENINDWCLSRQLWWGHQAPMYFAQIEGASNNDCDNKLWFSGRTIDEANSKAVKALPNQKFTLKRDEDVLDTWFSSGLWPFATLGWPKKTHDFETLFPTTVLETGWDILFFWIARMIMFSLKMTGKVPFTEVYCHSLIRDSEGRKMSKSLGNVIDPQDIIDGISLEKLHEKLLQGNLAPEEVEKATKYQKSAFPDGIPQCGTDALRFALVSYTTGGGDIAFDIKVIYGYRKFCNKMYQATKYVLGKLGENFIPAKSSKPIGNESLAERWVLHKMTIAAREINQALSEREFMKSTNIIYHYWYNSLCDVFIENSKAILQDGTLDEKRSALNTLYTALEGALTLIHPFMPYITEELWQRLPRRPQDTTKSIVLAQYPVYDDDFYDLAAEVAYELVLDVSRGIRSLMSEYCIKDDGIVYVQALDPISYATISQQLASIKSLSGKGLVNLTLLDSSDLRPAGCVVFPVSSAAKVFLHVKSRVDFASEILKASNKLEKTNLAIARQKKILEDEGYKEKVSKELQEIEKKKLQDLEVERSAFVETIKQFESLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC79</accession>
    <name>A0A0B1PC79_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000235">
        <property type="protein sequence ID" value="KHJ35838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC79"/>
    <dbReference type="STRING" id="52586.A0A0B1PC79"/>
    <dbReference type="HOGENOM" id="CLU_002173_5_1_1"/>
    <dbReference type="OMA" id="AENSSWW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="872"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137567" checksum="7881561ED7C641FC" modified="2015-03-04" version="1">MPQWSSRLLSPSSRNELGGSGKINGSSSPPTRLRPRGFESELTETTNGTSSLPQDKASSSDKAKVSPNTSHNRSVSHPFPSIFSSKKKRQGIAQSPPASNFTNKNTLSSGIPRESAKSKPLKQKYPDKDLMKGKCMTCDSLVRWPKELYVFRCTVCLTINDLKPIMLETRREDGYRIPVMSKFGVPMESRFSHKIPILSLEKINSIVDNCITAYLIDRLKYSNNYVLPPKQSDLAQNGTDVDEEFSENQCLTESNVAPLSIPHSTSHHEPQLKYTDPQRKPSQNSHDLTSNQFSSSTPGNFFPRHKSRKEQEVSSSPLKKSSGSLCDAAEKEIEIEQRIKYNVKRIFKPLEDHIVSAFGSFECVNSSFCTAMPNTVPRAMSEGPKHVSRICQPIERKSVAETQISEMDAKTLLLGDFAENGSWWTGSRTDVNSLEHLPTRRGRGISAYQEIGNLVTLKSPRINWAEVNEWYHTIFHAGKSWRRSLDFLKKTETCEPQRNFSDSELDRIDNDLLDARIHIQRVLLRATETLLKRPSRPLSDPSDLRFLLIILANPLLYTTPYASRVKQRSRSRSKLPHPQTALANKKSEPQTRLSSREPANLAKGNTANHSGIIKRVLGLLSNVSNECHHHLVSWFSRYPEIQFRRTTELIGSFVTYRLLIQGSKKRNIEQDPTAGLIPNMPGSGQGSSAALHAALGVTGQTSKKPASKPKVVVYSDDWQIRAAARVMSLLFSANSGVSIRRFEGRPLCESKIENSTSVGTRDTASNQGQIIATTDFYNSLLDCSDLIADFEAWESRRTKFSFCQYPFFLSIWAKIQIMEYDARRQMEVKAREAFFDSIMTRKTVKQYLELTVRRDCLVEDSLKAVSEVVGSGGEEIKKGLRIKFKGEEGIDAGGLRKEWFLLLVRDVFNPEHGMFTYDEDSRYCYFNPNSFETTDQFFLVGVVLGLAIYNSTILDVALPPFTFRKLLAAAPPPSPGGTSHVKPIMTYSLVDLAQYRPALANGLRQLLEYEGDVESTFCRDFLADVDRYGQVTQVPLCPNGEKRTVTNANRREFVDLYVRYLLDTAVSRQFEPFKRGFFTVCGGNALSLFRPEEIELLIRGSDENLDITSLRAVCLYENWSQKNVDENEPVVQWFWDTFQAANPLDQRKLLSFITGSDRIPAMGATNLVIKLTCLGGDGMRFPVARTCFNQLSLWQYSTREKLEHMLWRAVHESEGFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCE9</accession>
    <name>A0A0B1PCE9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative t-complex protein 1 subunit theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000062">
        <property type="protein sequence ID" value="KHJ36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCE9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCE9"/>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="547" mass="59622" checksum="06A2F2BC1AF82C87" modified="2015-03-04" version="1">MSLTIPNAPNSSLFKQGYNNYASEDGAVIRNIDACRTISSTVQTSLGPYGRNKIVINHLQKMVLTSDAATILRELDVVHPAAKLLVMASQQQEAEIGDATNLVIILAGEFLKQAEELIRMGLKTSDVIRGYELAQEFVLSELEKLSVDKVEDLMSPTELSKAIRTVIASKQNGSEDFLSGIVSEAVQAVLPKNPTNFNVDNIRVAKIMGGSLEQSKVIKGMVFGREPDGSVKKAIKAKVGVYSCPIDISQTETKGTVLIHNAEEMLNYTKGEEAQLDSLIKELYDSGLRVIIAGSTVGELALHYINRYGILVIRILSKFELRRLCRVVGATPLARLGAPMPDEMGSIDAVETMEIGGDRVTVFRQENESTRTATLLLRGATENHLDDLERAVDDGVNVVKAITRDPRLLPGAGATEMQLAERVQLFADKTPGLAQYSIRKYGEAFEVIPRTLAESAGLDATEVLSRLYTAHHKRDDWTTGVDIENNDNTGTLDSREMGILDLLIGKKWAIKLATEAARTVLSVDQIIVARQAGGPKPPGANPNWDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCI2</accession>
    <name>A0A0B1PCI2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ppe family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000929">
        <property type="protein sequence ID" value="KHJ34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCI2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCI2"/>
    <dbReference type="HOGENOM" id="CLU_099565_0_0_1"/>
    <dbReference type="OMA" id="FLACAQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059551" evidence="2">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="244" mass="25399" checksum="4DD2F5EB40BD7936" modified="2015-03-04" version="1">MHYVHILSFLACAQIAFSSPIIQQNRAKGAAGSTAKAAQPAKATTTKATQLYDNPGMLDNNTVTADSVKRAADNFAQDAGIVSNALNVMTTMTDQAAIKATALRAFKAESNEDNQRAVLAAAAGPAGATPNRKIQQYTPTVLDGLDAISKDASPDSVMKNTIMMENARNPNILPSITDLSNAALNAMGLDKSAQNLQKTVGQLGTGGGSTDRGTGSVDTNTSSQNSQNNQNSQNNQGNQNNSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP5</accession>
    <name>A0A0B1PCP5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01000877">
        <property type="protein sequence ID" value="KHJ34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP5"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP5"/>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="547" mass="61006" checksum="4C32026195F7227B" modified="2015-03-04" version="1">MRLGLKSSIVLHRISTKCKICPFTTQFSLRREVSTISSEGEEEVKQKLNDHNKKIRLTSETYPDIIRDSKFAKVSTEHVQFFESLLDKNGGVINGITEDAHDDLVSYNEDWMRKYIGQTKLVLKPGSTEEVSEILKYCNANMLAVVPQGGNSGLVGGSVPIFDEIIINMSRMNTIRSFDEISGVLVVDAGCILESVDEFLKKKNYIFPLDLGAKGSCQIGGNVSTNAGGLRLLRYGSLHGNVLGIEAVLPNGTVMDDLSLMRKNNTGYDIKNLFVGAEGTIGIVTGVSILCAQRSNAVNVAYFGLDSYEMVQEAFREAKVQLSEVLSAFELMDGKSQDIVFNVTKNQRPLENEYPFYCLIETSGSNSVHDNEKLSNFLEYVLDKEIVSDGVLAQDDSQVKNLWGWREGVSECAGHWGGVYKYDLSIPIRDLYGLVDDVRHRIEEAGLIGDTDEFPVVAVVGYGHMGDSNLHLNIATRRFEKKVENILEPYIYEWVGKRNGSISAEHGLGLAKKKYIGYSRSDTMIKLMKQIKNLYDQNGIMNPYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCW9</accession>
    <name>A0A0B1PCW9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative nadp-dependent malic enzyme protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000709">
        <property type="protein sequence ID" value="KHJ34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCW9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCW9"/>
    <dbReference type="HOGENOM" id="CLU_011405_2_1_1"/>
    <dbReference type="OMA" id="YPNMVVQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="9">
        <location>
            <begin position="106"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="8">
        <location>
            <begin position="295"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="596" mass="66556" checksum="9C9DA9802F11FBD0" modified="2015-03-04" version="1">MAEVGVKMSSLDVINRFHANSCPPIKRLSSSEHIQKSKTCGGIQLLREPAKNKGTSFSPEERASKNLNGLIPHVLETMDMQCQRAMRMIQSRSTNIDKYLYLSSIKASNIHLFFRILMDHVSILMPLIYTPTIGDVCLQYSTLYTRPEALYISIKQRKSISNILRNWPHSDPSICVVTDGSRVLGLGDLGVNGVGISIGKLSLYTAAAGIHPDKTLPVVLDCGTTNEDNLKDPLYLGLRQKRVSSQVAQEFMDEFMSAVIEVYPNMLVQFEDFETEKAFRYLERYRVNKCFNDDIQGTGAVVLAGYISAVRLSNVPLEDQKLVFMGAGSAGVGVAKQLMEYYIRHGLSERDAKDKIYLVDTKGLITTDRGDQLNEYKRIFARSDNNGRQLQSLEEIILEVKATALIGLTATYGTFTESIVKALKDSVEASGADRRCILFPLSNPLSKAECTFEQAIKWTDGTVIFASGSPFTPYTLQFNNHNTTFYPNQGNNVYIFPGLGLGAILAKTKCVTDSMVYTAAAALSGCLNEEEIRMGLIYPRIERVREASIVVAREVMKCSHKEGVSMLPEKMWAEWDEWGDVALTAWIKQQTYDPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDI0</accession>
    <name>A0A0B1PDI0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative guanylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000414">
        <property type="protein sequence ID" value="KHJ35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDI0"/>
    <dbReference type="STRING" id="52586.A0A0B1PDI0"/>
    <dbReference type="HOGENOM" id="CLU_017925_1_0_1"/>
    <dbReference type="OMA" id="EYHTENV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="634" mass="72852" checksum="897D84856AC16D70" modified="2015-03-04" version="1">MALKVAPIGMQTVESFGKFLQGMLRKAREIKKTDRVDPALHKSDFPGLLDEIRSIFHTSMSVDSRKQVIDAVARNTFYSLLASTSIDSPSFVNMWNLLDIVSILSDDEQTEPGLLFWLVEELLDSQTVAGCRNVFDYLESRRETIIAKHFNSKNLIILRSCNELLRRLSRAEDTAFCGRVFIFLFQSFPLGDKSSVNLRGEYHTENITIFDSVPYMIDSGQVLSGTTFHRARTSNSQKEPFFRGIKQITEDSPSSNSSASFSKNLPLMSADQLYPLFWSLQRYFSQPKELFDRTSFSNFKTGLEATMLMFKSVQRESNVDRISKSTDDSRRSLKRKRSNTDDGLANTFNPKYLTSRDLFELEIRDLSFRRHVLVQSLIILDFLLSLSAKSKEKLAKATIENPNKSVIYTDQLLSWEDTNWVLEMKKFIADYLKQSQDGPFFFRMVETVLSRDKNWARWKIENCPSITRPSVAPQDFVEARLSARKVSTNKKLRPNPIDSFDFNFLVEKEGHRGLERLKDPLRFSVPLVSSFKPKIETDDLDLEMASSEEEKNLIIQSKASKSWRALRVASTTKLVAFDKIERSDKIDEIFREQIKSDEVNNAEDEVVEEENQIQLKDPGLNFKFNQGSPVSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDX3</accession>
    <name>A0A0B1PDX3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000017">
        <property type="protein sequence ID" value="KHJ36453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDX3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDX3"/>
    <dbReference type="HOGENOM" id="CLU_019317_3_1_1"/>
    <dbReference type="OMA" id="KYAWESQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="159"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="48715" checksum="12FBA127B023388A" modified="2015-03-04" version="1">MFAQCSRYFIFIIHVIQTGANTWLNVPNSGLFRKFGSNNMASTGVQPKKVDLPSAANKEANEYIPSFISKKPFYIGEDDGQNDYLEHQRLQRAQSGQSKWYDRGKKLGPAATKYRKGACENCGAMTHKTKECLNRPRARGARWTGKDIQADEVIQDVKMGWDEKRDRWNGYDPKEYKIVTDEYIEIEEMKKKVLSKMDDGNEDSEDDAKYAEESDMGRQQSTATRQLRIREDTAKYLLNLDLDSAKYDPKTRSMVDSGATADTAAALVAEEGFMRASGDAAEFEKAQKYAWESQEKSGNTKLHLQANPTSGEYHRKRELEEAEIRREAHKKRLIEKYGATEYSDVTRLGAIAITQSESYKEYDASGAVKGAPKRIAKSKYAEDLYTNNHTSVWGSWWSKFQWGYACCHATMKNSYCTGEAGKCENPEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF23</accession>
    <name>A0A0B1PF23_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative suppressor of mek1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000368">
        <property type="protein sequence ID" value="KHJ35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF23"/>
    <dbReference type="STRING" id="52586.A0A0B1PF23"/>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="157"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="753"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="865" mass="98589" checksum="7872819E77072C0A" modified="2015-03-04" version="1">MMAQVPSSILQSNKRVKVYELRNDDWFDFGTGFCNTTFVFNEVTHAEEPRLFVYSEKEPDCTILDTKIYTTDGFKKQSETLIVWKESRTNLDMALSFQESEACSVIWKFVDHIQQQFHNLSNASINSDDVLSDDIAVDSSYGPISLPTPSLVSLPEVEVQIRGLQLTDQGRDALTKYVLTEEYIQKLVPLVEMAEDLEDLASLHRLCNIMKTMILLNDTTILELAVSDGVVMGVVGALEYDPDFPTHKANHRQWLAKEGRYKEVVHIDDDVCRKIHSTYRLQYLKDVVLARILDDPTFSVLNSLIFFNQVDIVQHLQSNPLLLKNLFSIFRAQQTNQKRKKEAVLFIQQCCAIGKTLQPNARQQLYDNLLSHGLLSVINFSLRHSDPGIRAGATDVLVSMIDHDPQMIRQTIFRQMSEKQTPLTDSLIDLLLVEFDLGVKAQISDAIKVLLDVSHSNVPQDNSSKPILGDPSGRLRNTDPQQMEFIKEFYDESAKKLFKPLIDLKDRKDMNFSVREVSLFIYLIEILCFFIRQHTHHSKYFVLSENLGQRIIKLLLSPEKYLKLCVLKFIRSLVGLQDEFYNQQIIQGKLLEPVLDLIMESMPRDSLLNSAAFELFNFIGREKINNLTIHLVENYRDKLMKINSVDTFSYLITRYDSSQGFSIIHADTEDETPVLPRPPLCGRWESGIKGLDAQEEEYFNTSDEDDEEANRYPSPPEILNVTSPLKKPLVDYLSDEEDATECDTPLENFVNLNDSPLRNLYDSPKSPCDGTGKTSQSLSPITPERLSDKRRREADEIDEIDKLSQASKRRNSMSSLGSNNILRRKKKFPNSPGSNPTKAKIAISISPVGKKSVESVKISDDTMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF57</accession>
    <name>A0A0B1PF57_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ring finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000354">
        <property type="protein sequence ID" value="KHJ35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF57"/>
    <dbReference type="STRING" id="52586.A0A0B1PF57"/>
    <dbReference type="HOGENOM" id="CLU_008264_1_0_1"/>
    <dbReference type="OMA" id="PGCSICT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059596" evidence="10">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="53060" checksum="93EB9D22CD972D4C" modified="2015-03-04" version="1">MLHSIFVLLLVSIIITSAQYIGATNDTLPEQETKSAFLLRLNGGALLEEKSYVVVPLTVAAGKGQSAVAIATYNIQGNFNIDYPVGNLTSSDIVFISCDSTNAVGNATEIVKNAAAQNPQAIVLFSYNSDACNHSGDFNYQSIYSLTTNGDTNDLISIASSPSELNDPIRAIISPNTSNGIGTPVMDTNNEGGPAPTTAVAMSILYSITGIITLLFLIIIATGAIRAHRHPERYGPRNTAFPGRPVQSRAKGLARAMLETLPIVKFENPKSTKDGDDMKCIENSLNASSEGLQDLSGRMEEGKTKKVDPIQKGPIESNYEIQEADLGCSICTEDFIAGEYLRVLPCNHKYHPVCIDPWLLDVCGTCPLCRHDLRPISPDSSGIVVAEGLPPPLSAIDEERYHSDNQEYNSRRNKITRFFDLTRLRQAPPDESIAALRQLRQQTQPYIESTNTADIEERNRSSRLTERLKDTFRIRTRTQPAGLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG72</accession>
    <name>A0A0B1PG72_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative serine protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000222">
        <property type="protein sequence ID" value="KHJ35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG72"/>
    <dbReference type="STRING" id="52586.A0A0B1PG72"/>
    <dbReference type="HOGENOM" id="CLU_023630_1_0_1"/>
    <dbReference type="OMA" id="CERFDVY"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000165">
        <property type="entry name" value="Serine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="59691" checksum="3283AE834E02EB15" modified="2015-03-04" version="1">MKLSITLYCNALLLGINAASKFQKLGQLITPPFSIKELPGYSDVSAAVEGSKNGTAFFQQILDHNDPSKGTFQMQYWWNAEFWAGPGSPIVFFTPGESAADEYTGYLTDHALTGLFAKEIQGAVVMVEHRYWGNSSPFADLTTKNLQYLTLNQSISDFIYFAKTVQLPFDTNQSSNSGNAPWVFSGGSYSGALAAWTLSTAPGTFWAYHASSAPVQLISDYWQYFAPVQEGMPKNCSVDIARVIDYLDGIMMNGTDSEKFAIKQKFGLESVEHDDDFMGALENGPWLWQANSFTTGYSKFYQFCDAIENVQAGASLTPDENGVGLEKALQGYANWTKSVLLPGFCQAYGYSDNLETACLDMYNSSNLFYTDRRVNNPMDRQWTWMLCNEPFSYWQNGAPSTRPSLVSRLVDAPYWERQCPLYFPPESNYTYGSGLTEDDLNALTKGWDLTDTKRLIWTNGQYDPWKTAGMSSEFRPGGPFQGTPEQPIQVIPKGIHCSDLRYSNAIANAGVKAVIDKQVKQIGIWVAEYYAQDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGG6</accession>
    <name>A0A0B1PGG6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4784</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000185">
        <property type="protein sequence ID" value="KHJ35961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGG6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGG6"/>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="OMA" id="GIDDPLC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="358"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="561" mass="63776" checksum="9389030E94DC3385" modified="2015-03-04" version="1">MQSLKVAVEGCGHGTLHAIYASVAKACEVRNWENVDLLIIGGDFQAVRNASDLTVMACPVKYRKIGDFHSYYSGARKAPCLTIFVGGNHEASNHLWELFYGGWVAPNIYYMGAANVLRLGGVRIAGMSGIWKGYNFRKSHYERLPYNEDDVRSIYHVREIETRKLLQIRTQVDVGISHDWPKTIETYGNTTKLFKNKPDFQKESREGTFGNVAAKSVMDRLRPPYWFSAHMHCKHAAIKVYNVNCEASSNNPSSSLPIVQPTKLDTLRKENNLDFDSKQQENNETSNKKSRSIKDVELRPDIVGNNPRGPVVNNCENMNKDLHSQYLEKAENTKSSVPESTRAQLPAAFFRSKSNLLSPPGITNKTVRFLSLDKCLPGRKFLQLLSIIPQNPPTSPKLLNKQKLRLEYDPEWLAITRVFDSEIVFGDRNAQTPPDLGETHYLPLIQKELEWVDEHIVKAGKLEIPRNFEITATPYQPGTPEIVKEGPLEYNNPQTQRFCDLIGITNKLFATEEERADRFQKGPAPVEEANRGNLKRGNDKNRKSNFNRNSRNFRGSRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGK1</accession>
    <name>A0A0B1PGK1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1418</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01000042">
        <property type="protein sequence ID" value="KHJ36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PGK1"/>
    <dbReference type="HOGENOM" id="CLU_001103_16_0_1"/>
    <dbReference type="OMA" id="LQSHISW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="902"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1504"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1633"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1637"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1653"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1669"/>
            <end position="1704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1732" mass="195942" checksum="E419871294B38322" modified="2015-03-04" version="1">MTRNNLDIHISWLLSQELSFNIPSKSHISSSTGGVDKSCPEDSFNGENANKDGSKVSLDLPVNLQPSLPINVGQIFENQAFQRTSFSPEDPNDSTLTERNLMGKLSVTSRSGRPGLISQNKIVTPKSSSTLQQEYALFLRDGASSTSIKSNGRSPRKKSISHRIPKNPLQTPESRRENIESVDLTGDSGGESFSGRIADVEFSKMSDEVTKSSKIELPQHIPKKRKGDGSSVLRQKNFNTGKNSNYEIEDLDEFVNVDELLSPLRPQKIHSDGNRSLQGSTSSNKLYPPLVGSVDNVIESGGTFEGFEISSRDTCREHKQMKFNLTSSNLEYMSPKNPQKKNASNSDTKSWPLIQVAASPSRQPLSSGSTLSEIPPKCMRSQKRWVIQDSDDDSNSTVGDIFSSSSFPLSRNSPQIVPDNKPIHQANSPIRHISLKSESISNKLSLIDDIRNETDTTQQKNSCSLPGHLEYQSPSLQEMSHTNVSNFSNPLEDTNLSRVTLTSSYMEDKKYVNLFLNQPSSIASYRERVSNLLAQNSIDSMVYIDANEPAPIKLKEERKQLLGRLKDFSTLESLGDRHRCLMAEKKDLVRKVVKLLDMNVDTSAHEERQSAISQEVKKLESEISQILNSCGAITDVLGSGISKDSEVTLTNSSQKAQNFSLLCIGNNREVDSQVIEQTQHQTNSPHPLNSNKVQRTDDHQPRLPLRCDNSALDINLNQACRPLTPSPKDNRIINPTFYQKPPKVYLDRMKSNFQNVSNEQQLHHHEPQIPQFNDENYFEDLLLEEAQITDEETSRFKVSKKFEENYGDSDYDEDMLHIAQEIEKKDNLPSISSRISQPTLPLVPKIQGHNFMQNKSMASRNMYSHVENQAQLFGYPWSKDVKKTLKERFKLKGFRHHQLEAINATLDGKDAFVLMPTGGGKSLCYQLPAVVQTGKTKGVTIVISPLLSLMHDQVEHLKKLSIRAATINSDTDVAERRNIMNYLREEYPEQHIQLLYVTPEMVSQSGQMRDILSTLHRKSRLARFVIDEAHCVSQWGHDFRKEYIALGRLRKDFPNVPIMALTATATQSVKVDVIHNLGMGNPPVFSQSFNRPNLYYEVRSKKGKKSPELLQEIAQLITNKYRGQTGIIYTLSRKGCEDMTKNLIKDFKIRVSYYHAGMKPEERSRVQRDWQSGRIQVVVATIAFGMGIDKPDVRFVIHYTIPKSLEGYYQETGRAGRDGKRSGCYLYYSWGDTVMLRKFIFEGEDSKSQEQKDREWEMLQTMIGYCDNQADCRRMQVLRYFGENFSKDECQHSCDNCCSGISFESRNFTNCSKLAMSLVWRLKNQKATVLNCVELLQGKKTKTLSKFNAEGFDEFGSCKDNTRGDLERIFYRLILENALLEENIVTRGSFTNQYIKLGPNSRDFMTGKRKVHLDVPVEKSLLSKRSTATAYPTSTILTSPISDVTRKRKRLKNSISLQEKTYESASDSDFSKNTNTRIKGIKRQQEKPKFGPPITVDEQLDKLPDLHREIVHNFVDQAKAIEEKIRNKVGARKPFFSESNFREMAISWPMTILDMKEISNINMERVDSYGKYFIPLVKHFYQSYNEIMGSKIYEKEKDMDKNHENVVIVSDDEENDQISTLDAEQEAAIRTAETSHHFNQSSRKLSSSQKVFRSSKGRGGKRTLFKRSLGSSSGFSRATGSNTKLKSSKSSGRNEKVSQGSGMSMFSKKYSYGNSIGDNKRIGGGGIGMMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGT4</accession>
    <name>A0A0B1PGT4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2758</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000010">
        <property type="protein sequence ID" value="KHJ36470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGT4"/>
    <dbReference type="STRING" id="52586.A0A0B1PGT4"/>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="148"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="26963" checksum="2E9B2C80704EEA8B" modified="2015-03-04" version="1">MSSSNEDDPFLQVQADVLSQLQHTRPLFTSYKRIRSFATSPNNPELSATKSELSVAIESLSEDLSDLNASVKAVQSDPYKYGLEIEEVVRRKKFCDDVKAELQEMSVELDINSSLTYKMKSDLDELDLDEATENDRNDYAALEQQMRLGIMAEQDYQLESVSQTVFNIRQQASDMGRELEEQAELLDRVDGIADRVGGRLQTGMKAMGTVIRRNEDGLSSCCIGTLIVILVLLLILVLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH21</accession>
    <name>A0A0B1PH21_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000127">
        <property type="protein sequence ID" value="KHJ36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210572_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25855" checksum="4E4820CA36D09473" modified="2015-03-04" version="1">MGADSGLRHQGIVGNQRADTLAKEACSLTLQTTKATAARARKLLEERYFNSLVLYADLHCSCGLEKSPEQPFSCRLNRRIRVLLYGSRKCTLGKIKWVLGTISGAQVFHKWKMALGGLIEAPSCQCGYRSQNVKHMIMACARWAKGRGEILRKAENRSFKAMMNNPKDMXNEGKLEQFRLVGAIETVIKQRRRKETSTNTNSTLYTGMYKLNVLPKGKFDKNIRLTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI04</accession>
    <name>A0A0B1PI04_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ibr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000027">
        <property type="protein sequence ID" value="KHJ36421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI04"/>
    <dbReference type="STRING" id="52586.A0A0B1PI04"/>
    <dbReference type="HOGENOM" id="CLU_025203_1_0_1"/>
    <dbReference type="OMA" id="KETDICE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ36421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="651" mass="75284" checksum="AB6978B5DFCA3C13" modified="2015-03-04" version="1">MQLVPVEYNEEAYILEVLQMKVSQVDLSNWQHHCEKVENTEIVTSPVMLTPNKLLQISSQGSEKSKPSIHVRSLSSASLSSSSTALSSQISCDLLEEASYTVRRKMEVMARMDVMNQNHENMNSLKNFDLSTTVNQLNPTSRTIASPKPHMRIKDRIRTKVFKPKQKLSQKKMSNQKHTSCCVRCREAFEYNKSLHCLPCNHPYCKCCLQTLIMQASEDESKMPPRCCTKIIPGAVIGAVLKEDDRVKFLKSVLQFRNRLESQILCPNVNCSGLFSEFEPTNSLRPLEVACRKCSLCICSLCKGPSHPLDVECPSEWARHTIVKLHDDKCQLSQGNCKESEEKLIQKNLSECETLNTSNEICKTVSHMDNIKLDPTPTIKNKKECKGRQEVSITGSSVHESYSRLPDNDDSEEMTAAKTRTAQSVDLSNLRAQQLVEKDRFCEFERKMGCYMTTRHNQERKNARETYEKRLSKMIEHHTKIAAQLEDIQVAAEFEMISAFKKTELNVRNRLRHMEAYCDALGRDSSDSSTGREVTERDLRQLGQQYNLRDSMYHIHQNKIKVLRDKQSKQMERLLMQQERELERFMTRREDITLAEQRFKKEKDGLSQLFAQRKSALLQKWALEEQNERERLEMENKQRYAPISPPIDWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIV2</accession>
    <name>A0A0B1PIV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000031">
        <property type="protein sequence ID" value="KHJ36414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIV2"/>
    <dbReference type="STRING" id="52586.A0A0B1PIV2"/>
    <dbReference type="HOGENOM" id="CLU_998179_0_0_1"/>
    <dbReference type="OMA" id="WQRRDIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="32512" checksum="3D659BF2B56796F8" modified="2015-03-04" version="1">MTTMLKSHMPFSLSSPSMQFSSSPPATPNTTSYSKNKYGRDCAMSSPSSFHSRSFNSITPRSCRLTKSYTTPSCGRRDLIPTSSTSSTSHYSRSKAAFSARQIKPNPLIFSRDSYRCDEDRATRRKLFLDRVKEAGEEKRWRERYSGFAEGDEETLRTLWLVEQRRWQEQRRREASGQEIPTDYEDLNEESHHVDQENAELEDFLFEEINSSNIYLPKRADQTENPIPLMNQILYNYDDDNDEVYDQIFMEVIQRETKILYPSAESIGKVEDYDEMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUU7</accession>
    <name>A0A0B1NUU7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative kinetoplast-associated protein kap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004992">
        <property type="protein sequence ID" value="KHJ30147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUU7"/>
    <dbReference type="STRING" id="52586.A0A0B1NUU7"/>
    <dbReference type="HOGENOM" id="CLU_412328_0_0_1"/>
    <dbReference type="OMA" id="MMRELEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="516"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="666" mass="75924" checksum="7AE440B5A31F185F" modified="2015-03-04" version="1">MQRNPGGSTVAQPASHNHHRYAEEYNYLAYRPDETRQSRSPQRLREFGYQERPPPVASRDPKSFGQVNLRTRRASAEPDNMSYRSDYVNGHGASPSHFDHSPSGPFPGRRPMVNYVNPGRGGPHPGQYESAPQSNYMMEQVPYSNINPRPTHQHQYPHVPVLPQANYYPNPQEQIAYIPQPQQPTQLVPQSTQLIPQQPQTVPQATSQALIQPTYDSYAAGRSNSLAPNGQYNPQWAENQLMRMKMDMEQQQREMAIEKAAREAKEKDEEERKKKAEEEAKHARDIAEARKKEREEIERQRKADEESRLATAKAIQEARLKAQQELEESIKRRQEEERIAREKEEEQREKIRKEFEEKARKEAEAKEAEAQRIAKEKAELEQRIKQERENAAREAEEKQRAAIAAQKAEAEREAARQAAIDKRIEEEKKAAAAKALEQLKAKQEREAKIAAEKAAEEKRLQDVQAEYDRLRKSAADERAKLIEENAKAKKEGEENAKKALKASEEAIAKLMAPPDKKRVIKFKDALGRKFSFPFDLCSTWQGMDELIQQAFQQVPMFRSAVQSHFYDLIGPNGEVILPQIWDTSIEPDFSITMQMWAMDQKLKAPEQAIPGAQAPPPPPPPPQPAKPAPASSQSTKPRRRAAEPKRSVGVLGWVAGRPTKPTRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVE6</accession>
    <name>A0A0B1NVE6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004575">
        <property type="protein sequence ID" value="KHJ30287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVE6"/>
    <dbReference type="STRING" id="52586.A0A0B1NVE6"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="559" mass="61404" checksum="183F014D0CEE4F13" modified="2015-03-04" version="1">MEISQESQAPSTETSSQLPPIPPIHCIPDSPPPTASHSPPSFPQPDNTLEGRKILKPTIHSKRTIPDRISAIGSKNTDIENAFLPKDLAEIIATRQRSERAWHARILICTTVISCIDSGLTIFEDEVEKEEVSALKAYLGLAIAKFAAVDSSPTPPHIPSHTHPRKANSYGLGKDKNVVKNVVVATPRIMKSATFNVVKEKEAPKLPKISQIGKKTWATVVRNGHKKTRVTLRNTSQVAPVIRATQQLSNKDKLPAKTLSDKRLFVRLPQDHEWRKLSPAGIREIIVQKLAISPSLFGKIKPVNSGFALSPCSTEARETILNAGNGLFLTGAKLEPATNWIPMIIPTVPSTIRKVQGEIEVSNSMLIDEVERVCSVRPAHVKLYGGNKAEAPHRTWMAYFSKAPRAGFRIFDESGIARPFKKQQILEFCKRYNGHHPSKNCSRAPSCGNCGSTNHTEDLCMAATKCRNCGGPYRSNSHKCLVRPTRSGKPTKEQMKTFRQVGEREYQAVLRAKAAEESATSAESNNIDLTNSQESEIDGNIDNIQASPIENPTGGASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVU9</accession>
    <name>A0A0B1NVU9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative short-chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004126">
        <property type="protein sequence ID" value="KHJ30497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVU9"/>
    <dbReference type="HOGENOM" id="CLU_2656306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="76" mass="8506" checksum="955C02F294F936B9" modified="2015-03-04" version="1">MAWAFVTPASRGIGFHLTRHLLQHTKLPIVATARKDVAIVKKSILSELPVSVDEERLKVLPLDVTGNKKTSFFSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX39</accession>
    <name>A0A0B1NX39_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004034">
        <property type="protein sequence ID" value="KHJ30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX39"/>
    <dbReference type="HOGENOM" id="CLU_018153_6_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="246" mass="27435" checksum="407569F50C87F783" modified="2015-03-04" version="1">MISYPLVSIEELKALTQKKTFQVTVPHVTPTDKPTLKKIPAPKHSLPKKPQLQEDSWVKVVRSGHKKSRATKESVELKEYNARAQGSVTPSSLSIDKTQSSLNTEDKRQFIRLSQGHEWCKLSPAGIREIIVRKLSISTTCIKFFNPVQSGFALSPCNTQAREALLQTTIRLSSLGVKLESATNLTPVIIPTVPKTIYTTEGSLEVPKRMLGDEVERVTGICPCALKLYGHSRHEASHQTWMAFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXA7</accession>
    <name>A0A0B1NXA7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 50s ribosomal protein l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003868">
        <property type="protein sequence ID" value="KHJ30618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXA7"/>
    <dbReference type="STRING" id="52586.A0A0B1NXA7"/>
    <dbReference type="HOGENOM" id="CLU_062853_1_0_1"/>
    <dbReference type="OMA" id="EFRVDKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28663" checksum="E5EDC84348BAA203" modified="2015-03-04" version="1">MKKRREALKKKKKTRTSYKVDNIDSLPKFSLVDAMRYLQAAEVGQKPTSVKYELAVKLKSLKNGPVLRNRLRLPHPIKTDTRISVICPPDSKYASEARDAGAVLVGEDSIFEAVKEGKIEFDRCICQLESLEKLNKAQLGRVLGPKGLMPSAKMGTVVKNPAELIREMIGAVEYREKLGVVRLAIGQLAHSPLELQNNIKAIMTAIKYDMAQIAEKVNKTIAEVVLSSTNGPGLTLNGKFQEPGSIDPKKLIVVDTVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXD2</accession>
    <name>A0A0B1NXD2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative zip zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003822">
        <property type="protein sequence ID" value="KHJ30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXD2"/>
    <dbReference type="STRING" id="52586.A0A0B1NXD2"/>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="403" mass="43564" checksum="A6730E7AF0D71E0D" modified="2015-03-04" version="1">MLDGLILLLTLIIVMTVTSFLAGALPLSLSLSSSQMRIISNFGMGILVGTSLIVIIPEGIESIYSAKSIEREHHLKRGFGISGVQKPKADNVVDIKDILYQKQANLNDIVVSTLPFILERDERTTKPQGTMQSGSGKTENQFQQCDNHDKHNQNTLTFQIGISLISGFILMFLIDNICRRASENLQSFLPTRHISLSNLSLNSHSGETSPGSESFLNSLTPTPKQTRSVTTTTGLVIHALSDGIAIGASITSSNIKLGLIIFLAIMLHKAPTAFGLTSILLKQGLSKRAIRAHLMIFSLATPAGAATTWVLIAILGASQIEEESGQWWVGISLLFSAGTFLYVSIHAVHQENSSNYSHIASNGVLEAGINTVPRKVSKLQLRDTLAAVCGMLVPLVTQLDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXS8</accession>
    <name>A0A0B1NXS8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003139">
        <property type="protein sequence ID" value="KHJ31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXS8"/>
    <dbReference type="HOGENOM" id="CLU_1533712_0_0_1"/>
    <dbReference type="OrthoDB" id="5361354at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="175" mass="18801" checksum="918B15ADE094422E" modified="2015-03-04" version="1">MYFLGLGTSSLFAAGLAFLVILTFFAGLVKVALNKRDLKKKIKLAKLEAANKETDLEKLVGQRPLDEGDLFGVRAIQAGFFGGVTQSCPNSPVPSRSSSLNSLEIKYCESHSPKPSPCRLEPPRPTCNISLSSRKTSASSQRSSSGSDSNISSHPENSNSYDELGIVARPRALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYI2</accession>
    <name>A0A0B1NYI2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative p-loop containing nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005162">
        <property type="protein sequence ID" value="KHJ30095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1NYI2"/>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="307"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1419" mass="163534" checksum="F9279EB8E9EA5C7A" modified="2015-03-04" version="1">MSKAESVIASDQIPDIPDQLIDFFQDSSVSEQPRKRRKTKLGVYINERPEVTCNQQKFIIVNQSILEVKCQKSRLENRLLPIKRYNIKPHVCWAQSSEPEYIEIRDHFHRPIFHISVPTVKDRSDIFIALLVDKCKIKAAKTHNHLWTEFDIRLIRDGYFDVIQLVFIIRWNITTSPREIISNEKRPLALIKVLELFFPDPRVKVESSSTPQDFYSSVHSPPKDCCHAENIVIPNVKFTLYPFQKRAVQWLLRREGVEWANGSLQNFTHKTITNELGSFIESTDFVGQKFYVSHLFGIATFDIKPFIASERRVKGGILSEEMGLGKTIEMISLIALHNLSKSSSRIVFDSLLDTFIRSTSATLIITPPPILHQWITEVKQHAPLLKITLYEGMKTHQKTDFFELINELAKSDIVITTYSVLAAEIHFTQLNPEKELRHQPKYQRPKSPLMMLHWWRCVIDEAQLVESGFSNAAIVARMIPRVNAWCISGTPVKKDINDLRGLLIFLKYEPYASAKHVWKALVTTHKHEFSKIIRKLAIRHSKRSIRDELHLPIQRRFVITMSFTLVEEQNYLELFKEMCNEVGLDTEGRPLNKGWKIENYCEIMRRWLCRLRQTVLHPQIGSKNRKALGQKDGSLRSIDQVLDAMMDQNQASIRTDQRAMCLLKLRRGQYFESSDRINESLQIWTETAREVSIIVQDCRDELNQELARIKNESKFLVPGCDQITENDPNCDEEQGEVDPTSQLGILRNRLRGALEVEHVAQFFLAGAYFQIKSNKEITSPNSLKFQQLQTLETRGYENAKNLRKEILRDVTYKADRLMKNVAEKSQSGVLIEIPEFSLGNLKNTKELKHIDKSLDELAKALDSQAVVIKDWREIIIETLLRSLVDEDNGQENTGNEYDDSTKVQEKLMVYVQALKIVICDRHDVLTGQTNNLIRDEVKNAIRLAKNGQGVFPEKIITLLGLREKIKPNTKGSVRGVVNELRSVFNSLKLNATNGNLKAQKEILIVEKKLKHIQNQMSIHLKVMVALEKELELFTIVMNTRVEYYRQLQQISDMVTVYDGPIDEKTLAKMLHDEQSLIDKINISKSKHRYLCHLRQEVNNPDDQKICVICKEKINIGTLTVCGHQFCKECISLWWSSHRNCPVCKRKLAQADLFKTICPNQISIRADNYIDEQTIQSGSCSSPCEKSAIYTDICQSKFTEIKNIKLEGPSFSTKIATLARHLIWLRYSDPGAKTIIFSQFKEFLHALTVALEQFRIGYSSIDRANGIEKFKCDPSIECFLLHARAHSSGLNLINASHVILCEPSINTALELQAIARVDRIGQHQETNVWLYIVNDTVEKSIHQLSVRRRMEYLDKKILAKSNSQYTDMDMDIEKNIEEANSMQLNQTYYKKLLAKDGISGEEVASSDLWECLFGNREKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYZ7</accession>
    <name>A0A0B1NYZ7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g1574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003123">
        <property type="protein sequence ID" value="KHJ31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYZ7"/>
    <dbReference type="STRING" id="52586.A0A0B1NYZ7"/>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="38890" checksum="D570C8D9856609CA" modified="2015-03-04" version="1">MSSFVLSKDSPLSFLFDNIFSTTLADVYTSFSERREKLGLSNPGSADNIAREVQRDVLLSNYTFSGLRADLTKAFSMSPLFQVSHSFAMGSQSLPPYTLAALFGTNKIFMQGNVDNDGNLSTRFNYRLMQSLISKTQVQISPGNQSMAQFDNEYTGRDFTASLKSLNPSYIDGGLTGIFIGSYLQAITPNLALGLEAMWQRAALNQGPDAAVSYCARYKGSDWALSAQLAAGGAFNASFWRKLSEKVEAGVDCNIQLASAPVDSMMGNLRKEGKTTVGAKYDFRMSTFRAQVDSTGKLSCLLEKRVAQPVMLTFAADMDHSKQQAKIGIAVSFEAGSEELQNQQESSSGPPQIQIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZK4</accession>
    <name>A0A0B1NZK4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002932">
        <property type="protein sequence ID" value="KHJ31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZK4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZK4"/>
    <dbReference type="HOGENOM" id="CLU_036943_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="311" mass="33922" checksum="59360C5AC2F36ADA" modified="2015-03-04" version="1">MAPPVFNKRGPPPDPPDAGNRVSKTTSALNRKSGTSITKPRSTPHANVALHKSSILEKNFGAEQFSIDDQVDKADMDVEPEELSINTINSDPFEEDFPPLSGISNANVAKSTKESSKINEESRSATLLMDAIKGLLDLTNPYLKKLEEEHPGIGIDFMALLADGASRAMRGARVYTNLSNISSSNPKVSKPSWAEKAGAAVNGQNISLKKQTIRASPPRGQSKEDRRVIIRLGPDHEARKTGSFELRQKIQQLIPDKSLIEDVWAVPSGVAILAATPAKAATLLQYKEAIENRFGDANVERQETWTTFVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZY2</accession>
    <name>A0A0B1NZY2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002811">
        <property type="protein sequence ID" value="KHJ31543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZY2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZY2"/>
    <dbReference type="HOGENOM" id="CLU_070147_0_0_1"/>
    <dbReference type="OMA" id="QIVEVCM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28805" checksum="E49F9F93DF8BCC79" modified="2015-03-04" version="1">MSRKGVGLGAFDRSRITSAQYASHGNSIRNAHSTTLATQLSVFRSLLQQFSQTHAKEIRSNPHFRAEFARMCTTLGIDPLASSSGVGRKDAGGSFWAQLLGGSVNDFYFELAVRVVEVCGATREENGGLIGSNELRQRIMSTRMEGGAEITDDDILRAVETLKPLGSSYSTLKVGHKTYIRSVPKELNTDQSAVLEVVQLLGYVTLSMLMINLQWTRARAKTSIKDLTSEGMLWVDKQCDEWEYWSPGIMLQNSKMNDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P009</accession>
    <name>A0A0B1P009_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003860">
        <property type="protein sequence ID" value="KHJ30625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P009"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="249" mass="27725" checksum="6D5A42C9C0063B89" modified="2015-03-04" version="1">MRKIKPVHSGFALSPSSSEAREQILKAENGLFLTGAKLEPATNWIPILVPTVPAFIQMEQGKVEVNKNMLSDEIERVCSVRPVHVKLYGRNNPEAPHRTWMAYFSNAPRSGFRVFDESGIMRPYKKQQPLEFCKRCNGHHPAKNCSRAPSCGNCGSTNHNTDKCMAATKCRNCGGPHRADSRRCLARPTRSGAPSKEQLKIYRQAGEREYQAVLRARVAEEKAATTESINIDLTSSPITEINSSTDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P094</accession>
    <name>A0A0B1P094_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="JNVN01002684">
        <property type="protein sequence ID" value="KHJ31668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P094"/>
    <dbReference type="STRING" id="52586.A0A0B1P094"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="WSQSMGN"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061668" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="459" mass="50240" checksum="70BDA95B196966C5" modified="2015-03-04" version="1">MTFHFLIFATVALLLGSRVVYGIELDITSASSIRDAASTIAYDMMTYYKGNQSGGIVGVLPGPPPDPPSGYYWWESGAMWGTLIDYWHYTGDSSYNDVALKGIQWQVGENKDMMPSNWSQSMGNDDQAFWGMTALLAAETNFPNPPANKPGWLALAQAVFNTQSRRPDKECGGGLRWQVYPYLTGYDYKNSIANGCFFNIGARLARYTNNNTYAEHAETTWDWIQSVGLMDSNYNIYDGAHIGTNCTDINKVQFSYNMAVWLLGAANMYNYTNGSEVWKQRTTSLLNSTLTTFFPNDIAYEVACEPKLTCTTDMFSFKAYLTRWLAATTLVAPYTYDVIMPKLKASAIAAAKQCSGDTNGRTCGLSWSKGDVWDGTKGVGQQMAAMSAIFVNLLSLEYIAPPLTNETGGTSLGNPNAGAGSVSDPTALKPATQGDRVGAGIVTTLWLLSVTMMFGWMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0G5</accession>
    <name>A0A0B1P0G5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002297">
        <property type="protein sequence ID" value="KHJ32147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0G5"/>
    <dbReference type="STRING" id="52586.A0A0B1P0G5"/>
    <dbReference type="HOGENOM" id="CLU_169175_0_0_1"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058801" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="76" mass="8206" checksum="37DDA771B70BED01" modified="2015-03-04" version="1">MLFKTILAFFPVFQVIAVHGAVIKAVGDEGGNIPAFRIDATSRDGSRRDPFQGDKKHSRIVNVDVCGNTVEDGSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P103</accession>
    <name>A0A0B1P103_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003387">
        <property type="protein sequence ID" value="KHJ30975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P103"/>
    <dbReference type="HOGENOM" id="CLU_2484992_0_0_1"/>
    <dbReference type="OrthoDB" id="3595805at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="87" mass="10225" checksum="F857E37AC277EEDD" modified="2015-03-04" version="1">MILPWLDQGKMIYEEAKELKLAKVKDPQQQYEFLFTISHIEDSWVTAKLTSIETDLYHVKATLDIPCLIGEYRHHQILAYIFSKNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P116</accession>
    <name>A0A0B1P116_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubx domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003889">
        <property type="protein sequence ID" value="KHJ30611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P116"/>
    <dbReference type="STRING" id="52586.A0A0B1P116"/>
    <dbReference type="HOGENOM" id="CLU_534160_0_0_1"/>
    <dbReference type="OMA" id="APKYDWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="1">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="481" mass="54550" checksum="80C595BA5E5FB5CC" modified="2015-03-04" version="1">MASNVVVIDTSFRRATIKVTPGTYLTDILEEACRKFNVQQTLYDLKYKTKSLDLFQTFRQSGLASGSKLELVLASRSSTPVSVALDLPAAYASLASNCRIVEKFSNDTTIWLILRKFESKFGDALNITARGATKDCSVMKDEGNKIFYEIPVLNVMGRELSNFEDFQKTLRQLGFNSGTCLIKLSFKKTNQLLEEAQQHIQDYFQVDCDLKTEDPELLTESFASLEKYHEDSTDVFSKEAITVSEASNQQISTLEGDKILLSDSDQNRSLEIFAPPSNQIPRAASIPHNDADFEPTITHAKLHQSRLQSDSQNKRLLSDIEKERVEKEKEDKVAKISEVSIKIRFPDQSTIVSTFSAEETGLNLYQFTTNLIEEEERPFKLTWHNKGPQIIPKDDKKLVRHLGFQNRMLVNFSWDGPKNDAAEKRPILKLKYANQAREVVHPIIPTSEEPDNIESLEKVDVGVQGKNQKKVGKWFKGLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P118</accession>
    <name>A0A0B1P118_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pwwp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003368">
        <property type="protein sequence ID" value="KHJ30990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P118"/>
    <dbReference type="STRING" id="52586.A0A0B1P118"/>
    <dbReference type="HOGENOM" id="CLU_019479_0_0_1"/>
    <dbReference type="OMA" id="WPVIVCD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="604" mass="68294" checksum="748F2CE93DD46972" modified="2015-03-04" version="1">MSEETEMISSDDSDTKELSSSKPKKSSGNGSGQEGSENFTPNSDVDQNEKIKVAIDAPDKTLDQVDESDNQLELQDSENYEHLSSVPKNSKTESLIDVLDQDLSVKKADLKSTNINSCSDIKSKARRRSSGVPEHRTKKINKKASKAKLTHIDAKPGDYFYVRLKGYPLWPAIVCDEEMLPKSLLKTRPVTAARADGSYREDFMDGAPKAKDRSFPVLYLYTNEFGWIPNYDLLEIDFDEITNTTGSMRKDLATARQLAAEKHDLDYFKQILKSFMEETENERLENEKAEEEKLMPKDKKDSTDRKKTARKPKKSKVVIPKDEDSSMLDRNTKPDSEDPDSNYLAVCVKRSANEPLEGPPKKRTTIKLTTKAKPEAEAPKHSKVSDSKKNKLEKPEKVAKVKKIKVSLAPSITASTPNLTLEPELSIEEKRLKREKEILFLRHKLQKGLLAKDQEVKIEDMKSMSEFIEKLEAYNDLEATVIRQTKINKVLKAILKIPKIPLENEYKFKPRSQNLLDQWNKLQIVDSGISASSHTNGVNLEVKAKPEEDDCLKTEPKDVIENENEAKKVTESSINAKIQVVDDAIDLIPDESKKVSTKHKNSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1C2</accession>
    <name>A0A0B1P1C2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002100">
        <property type="protein sequence ID" value="KHJ32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1C2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1C2"/>
    <dbReference type="HOGENOM" id="CLU_056580_0_0_1"/>
    <dbReference type="OMA" id="RTKKDNH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="64"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="314" mass="35953" checksum="629FE8FB66E65C28" modified="2015-03-04" version="1">MSTHLERMQSGFINDAKLSASKVATKRINLNSSSSEHTSTQQKRELKEQKRKREQGNVVFSQPAATGYGTEAFTQVTYVIEFLKKKDEPKKFQEILLYLSQVNADERKKRLIAKILKQHDRVKWTPDPNLKIQTWDSGLFEHCPIINVRTEDDLLRYLQKMPNAQGVSVKDLKDGWPDCDSAIDKLEKEHRILVTRTKKDNHARMVWSDDPTLAHNVDPEFQVMWHRVELPSVDELVRKLLDASQKPASEDPSKRIKAAPKAKEKKKRAPRSGGKTTNTHMAVRTKSDSLRSPLTIFVAFAQGFFPPQTLVIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1H3</accession>
    <name>A0A0B1P1H3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01003217">
        <property type="protein sequence ID" value="KHJ31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1H3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1H3"/>
    <dbReference type="HOGENOM" id="CLU_046496_0_0_1"/>
    <dbReference type="OMA" id="WEGLKQS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="92"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="36606" checksum="E63525F274F57130" modified="2015-03-04" version="1">MATLILQSLGCDVAAINTVQLSNHLGYGRARGSRTTPLEIIEIWAGLNEAGLNNFDILLSGYLPDESFIDSVLRIVRESRQNNRKNSKETLFWLLDPVMGDNGRFYVSETIIPAYKQALPYADLILPNHFEAEILSEVKILDVKTLETALSTLHSRFNVPHVIITSLNLTYPGVDKNSLIIAGSSMKSDKSPRIFIVKVPKIDCLFSGTGDMFSALTLVRFREAVCEIPGLTQVSHWLSLDSVRSIDLPLAKAAENVLASMHEILTISIKCRDEEMNAYYEMVGGVEAANANENASRKHKAALAKAAEVRISRNLPLLKYPMKMFNAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1R9</accession>
    <name>A0A0B1P1R9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003098">
        <property type="protein sequence ID" value="KHJ31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1R9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1R9"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="206"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="313" mass="34573" checksum="C465AF705294E71C" modified="2015-03-04" version="1">MHGSRSQVVIAGAISGMTARFFIAPLDVIKIRLQLQTTPINSSLSRRSPFFSPLDTGALSTLRKILKYEGITALWKGNIPAGLMYISYSAIQFTTYRSTSLALQNFLGEHYFSTAAESFIAGACAGATATTATYPLDLLRTRLAAQGTEKIYFSLAHSVKKIYKSEGSNGFFRGLGAGVGQIVPHMGIFFSVYETIRLPLGTLRLPFSTGDALAGVLASIIAKTCVFPFDLIRKRLQVQGPTRSKYFYKDIPNYQGIFQTFQKILMSEGPRGLYRGLTMSLFKSAPTGAIIIFTYEKALHMLMKFDKIYQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1S2</accession>
    <name>A0A0B1P1S2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001960">
        <property type="protein sequence ID" value="KHJ32597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1S2"/>
    <dbReference type="STRING" id="52586.A0A0B1P1S2"/>
    <dbReference type="HOGENOM" id="CLU_003212_0_0_1"/>
    <dbReference type="OMA" id="FWGHCVF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ-like" evidence="7">
        <location>
            <begin position="383"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ-like" evidence="7">
        <location>
            <begin position="858"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111821" checksum="FD2E58CE6BC222AB" modified="2015-03-04" version="1">MNGLSSPTKRKQYPGPAIERPIKQQKLLTGMDSNHLNTLSDEDLEIEVEETRIVPGVADSAEWQACIENVVRNVVSIRFCQTCSFDSDSALTSEATGFVVDAERGYIMTNRHVVGAGPFWGFCIFDNHEEVDAYPVYRDPVHDFGILRFNPKAIKYMPVTSLTLRPDLAKVGSEIRVVGNDAGEKLSILSGVISRLDRNAPEYAEGYCDFNTNYIQAAASASGGSSGSPVVNIDGYAVALQAGGRSDGAATDYFLPLDRPLRALRCIQEGKPITRGTIQCQWMIKPFDECRRLGLTILWESAIRKNFPKETGMLVAEIVLPEGPSYQKVEEGDVLVKVNGELLTQFIRLDDILDSSVGGHVKLLLQRGGEDIEVDVEVGDLHSITPDRFVSVSGGSFHNLSYQQARLYAVACKGVYVCEATGSFRFEHMDSGWIIQTVDHKKTPDLDSFIEVMKNIPDRARVVVTYKHLRDLHTLNTSILTIDRHWSQKMRLAVRNDTTGLWDFTDLADALPAIPPVPRSASFIQLSNTQHPAAADIVRSFVRVLCNMPMKLDGFPRNRKWGMGVVIDAEKGLVVVSRAIIPYDLCDITITIADSIIVEGKVVFMHPLQNYAVIKYDPSLVMAPVQSAKLSVTHISQGASTYFVGFNQNMRIVIAQTTVTDITAVAIPANTLAPRYRAVNVDAITVDTSLSGQCGSGVLVGEDGTVQALWLTYLGERSPSTQKDTDYHLGLATPCLLPVIRKIQAGERPHLRMLSVEFNAIQMSQARIMGVSEGWIKKVAEDNQSRHQLFMVRKRTFERGDDKATLLEGDVILTLNGKIITRVSELDVMYDHEVLDAVILRDCSEMNIKLPTVSADDLETDRAVNFCGAVLHRPHHAVRQQISKLHSEVYVSARTRGSPAYQYGLTPTNFVTHVNGKPTKDIEDFLKVVVPIPDNTYFRVRAMTFDNVPWVITMKKNDHYFPTTEWIKDPSELSAWRRVTYEKGKPVLGEGHEGISSVLAESFDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W2</accession>
    <name>A0A0B1P1W2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002227">
        <property type="protein sequence ID" value="KHJ32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W2"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_0_1"/>
    <dbReference type="OMA" id="DITNITW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="36937" checksum="1953C39F895188C2" modified="2015-03-04" version="1">MVANLEVCTVAINGVEGALAHLKSGTRNDFVVSLKVYLQNAIAQFMRSGTSAIPPSLPCRPTDPPPAVPVIKNTARSTPTNKASIYHPTKNQVNKTWANIAQKGHQNLPSDITNITWTPTGFALTSKDEETRQKILKNNEGLALQNAKLEPASDLITYRIATVSVALGTPNGMVIVEETNLAAEITRVTNVIPRMVRQHGKTRAGAPYRSWLAHFARDQAPQPGFRLFDESGIAVIFIPRQPIQQCPHRSDSRNCLARLSRSGPVTKDQLKTIRQMSQREYHAEARAKAAIIRAEAAAINEETPSIYPKNNLDFISTNEVEMSEASIDVGTSSEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X0</accession>
    <name>A0A0B1P1X0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g6068</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01003488">
        <property type="protein sequence ID" value="KHJ30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X0"/>
    <dbReference type="SMR" id="A0A0B1P1X0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1X0"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="609"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114733" checksum="031BE8E1F3D8E801" modified="2015-03-04" version="1">MSSPRSLPRPYSQNSSPRPRSQRNSTLLPPSSPTEAAAAQLRSEAASSQGLANPTRNGLSNSSSPRFYRSSPANISGLGKNRRERDVSSPLRQMTNSQTPLDGDRTIRASRLARDSSPIRYAPSSSPGLTSRQQSIQPDTPSDSSGLFVQSSRGNLGTGSAINISRRGDINSGNLNTPRARNRIFMDESGNIVREIPSEASGAPTFSNLDPNTSDAAAMGGMSQFCIWGTNVSITDTLSIFKSFLYNFKKEYRLWADGITQEETAQDPDANTREYIELMKDMLRLGVTSLNLDFRNLKAYPPTRKLWQQAQDYPQDIVTLMDQGIKDVMYELAEKEMSIQRQSRNASQKSRQSKMLSSEPPFPSSDQENNDLHTTVDQENEELDLCQEVQRRSYRVRPFGLDKTINMRDLNPSDVDKIIAIKGLVIRTTPIIPDMKDAFFRCQVCNHTVKVDIDRGRILEPTKCPRPICDSPNSMQIIHNRSEFMDKQVIKLQETPDNVPAGQTPHSVTMCAYDELVDLCKAGDRVEITGIFKASPIRVNPRQRTLKSVYKTYIDVLHIQKVDKKRMGIDVSTIEEDISAKFGSNIEETRKVTEEEKQRILEISNKPDLYDLLSRSLAPSIFEMDDVKKGILLQLFGGTNKSFEKGGSPKYRGDINVLLCGDPSTSKSQLLQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPENRQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSILASANPIGSKYNPNLPVPQNIDLPPTLLSRFDLVYLILDRVDESNDRRLARHLLSMYLDDKPHSAAGNLEILPIEFLTSYISYARSTCQPRISSEASEELVNSYVEMRKLGEDIRASERRITATTRQLESMIRLAEAHAKMRLSETVTRDDVKEAVRLIKSALKQAATDIRTGLIDMSLLTEGISASERRRKSDLKNAALNLLNDMTSQGQSTRFNEFVRRLGDQSSIPVEQNEVMEAIRALEQEGLLTVVGEGPRKSIRRVTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P283</accession>
    <name>A0A0B1P283_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002127">
        <property type="protein sequence ID" value="KHJ32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P283"/>
    <dbReference type="STRING" id="52586.A0A0B1P283"/>
    <dbReference type="HOGENOM" id="CLU_001650_21_5_1"/>
    <dbReference type="OMA" id="FEMIDIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="34632" checksum="E0F28BFA3D9B2123" modified="2015-03-04" version="1">MEVEYNTLLEKNTFEQIRQTDSMHPIPLKWVYTYKIEKSGYLIKFKARICVHGDLQPKTDGETYASTLALQVFRLLMALVALFDLETIQADAVKAFCNSPLDEDVYLNNPPGFNKNEFILCLLRGLYGLRKSPKLWFKLFSGTLSDIGLYSIPGQPCIFTEYQGIVIFFFVDDLVVAFPADKRSKALNYLKKLTQKYELRILGKLEWFVGVKITRYQSNKKFFLSQEANIEKICCEYSCDQSGRQVSTPLVSDNLQKYDGNATDKETKLYQQKIGSLINASSDTRPDISSRAISKPFSRVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2C0</accession>
    <name>A0A0B1P2C0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative tip elongation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003257">
        <property type="protein sequence ID" value="KHJ31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2C0"/>
    <dbReference type="STRING" id="52586.A0A0B1P2C0"/>
    <dbReference type="HOGENOM" id="CLU_003115_0_0_1"/>
    <dbReference type="OMA" id="KWCAVCE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="362"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="698" mass="76752" checksum="FC4E75D5A716810F" modified="2015-03-04" version="1">MPSLSPHDGNLKLGDMVEVPGKMHGNVKFIGTVDNKKGIFVGVELSEEFASRGKNSGDVDGLSYFVTTIPGAGIFLPINRATRRISASAINNGSLSLIPGSPINSGIKTLSQGPNNHTTSTTGILKFSQSMGVGRAPSPQCQKVRHLSLPRPESPVRRNQNSLKSPNLSPNGKTPTKYGNSSMKKFRQSVRGTQDSRDPVKKIIGTPRSLNSSGLGNRSTSALGLSSYTQLDQRATPIDFSTAKINSAQTNIESSTCSKVSVNEENSRLRALLVERDRQLKEQAISLEEMEKALAEVQKLIDSDNNCRTKRNSIEDRDVFQLRAMLREKNEKIYMLTTEFDAHRADFRSTIDTLEMASSETERVYEQRISEMMQEINDLSSQSVDVNNVANHLKQLEELVQELEEGLEEARRAEVEARGEVEFLRGEVERTRAELKREKEKASRDSIGTGSIANGVVVSKELKQRDDEIRGLKKIIHSLSRDSVQDLVEDISMPSTRLSSSFSEGIKLAESKRDSKNMKRDSVETSQNFDSKTNAAGELHQEGGDINQESRGTLITGTATNQGSSVVSNPQIKIVSLTDHGCHTNLDFKTRALNTEIGLESDAYSSANESFCELCETPGHDILICSKVFALAPYSDNKSTSFPSNKNSKVPSEQVIINSIETEPIAGKESGVVDMDKWCAVCERDGHESIDCPFEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2D6</accession>
    <name>A0A0B1P2D6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ribonuclease p 40kda subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003247">
        <property type="protein sequence ID" value="KHJ31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P2D6"/>
    <dbReference type="HOGENOM" id="CLU_048755_0_0_1"/>
    <dbReference type="OMA" id="DVDPYLC"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="296" mass="34098" checksum="D1A3DC10D6AB5694" modified="2015-03-04" version="1">MPEELYPTIEKCILSRDYAFNYSRVILPLKALLEEDFFNEYIKKGNILMLSEGQIGAGNVYFLKEGKLRLHLDRKSYESAGLVGKPDGTMASQGIKKRWMVEIDFRQPSMLHGKKGFNRIIYAFEKVLVHPVTWLLCNLNLTTPTPDPLDKHFPVKKTATPIITRNKIVNKPSLQPPPETNLEFDYFAMETHEWLSLIMLDSPRVCTNDVIDPVLSRYCPPGETTESKLAKIVWRGFISPSSAHKLFKDILLATPREFWFTINISGFPLEFLRECKDCMILRVANTSMEFVLWETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2F3</accession>
    <name>A0A0B1P2F3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001782">
        <property type="protein sequence ID" value="KHJ32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2F3"/>
    <dbReference type="HOGENOM" id="CLU_2185914_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="109" mass="11344" checksum="DB2EA262DEF3B55C" modified="2015-03-04" version="1">MAAVFNTGFYPHVGFQIALSSQILSPLPLPVPISSSVSVTADLALRGLALVPQPPAIMIPPILPTAPANPSNLPNTSNPANSPSTSNTAGNSRIIRIYSNKSLVINNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2N9</accession>
    <name>A0A0B1P2N9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dna mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001704">
        <property type="protein sequence ID" value="KHJ32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2N9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2N9"/>
    <dbReference type="HOGENOM" id="CLU_005415_0_0_1"/>
    <dbReference type="OMA" id="NKWPMFY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="713"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="984" mass="112075" checksum="D23B310758DD69DF" modified="2015-03-04" version="1">MSIVALPQHVTAQINSSSSFTCLNDVVLALFKNSLDASCTKIEITVDYSRGLCVVEDNGVGILPSEFRESGGLGKPYHTSKQYETEVVHGRRGNSLASISAIAFLTITSHHFLYQSHNTLCINNSAVLFRQLPALPQHHLLYDHGTRVTIHNLFGNIPVRIKQRVINSRKQGGNGKEWNDLLIGLIRLLFPWTRAQVSVTMRDKITNNKIYLQAPSHKSVKESPIKKFCSILRQASIITAEDTRSWIPVQASTEGLRIIGAVSLQPYVSKRCQFLSFGIKPIFPEESSLYEDINKLFSNSSFGNIEVASKIEGQEIKHCKDDKRCKRTDYTSKELKCVKGIEKWPKFYLNILPEVTVEKSLSDYADCNFWTKLESYSMKVRELLQELIWKFLSDNSFLPRPICQKRFKKDGLISIPAVESLPQSMIMNSTQNHPLSSTSSLAQRKKIIHNEFGMDIKLPSFRQNVLSLELSNDITSKIKRGKLTRASSISMLNNESKLDDQEFTERSFSLPLKVTNVLEPRVCERQIFKVSEKKIFSMSAKPLTCELIKDSEVPEKCSCNFLSKNDSDFTPSFQPSEIHRPIAPKDTISSRSNSMTHNQHNFGQRIDFLVAPQTFQLESSTKRFFRQKICTKMTPNDPNSWMSQCLRSWNNPVYVPAEKPIPQLSIESQHLKQRFSAGQFQNYIQADANHRPDMKGARLNNRISKRALKDAKFISQVDNKFIFVKVFTTDCKELAQRSEDLLVMIDQHAADERIRIESLLEELCTPAMITEVDSPYRVKSYILMRPLIISLPPNEIELLFTYRNYFLSWGFSYKLPAHGSVSNQTNNNQTLIVLSLPPVIAERCQQQPHLLSSLLRKEICKLQDSNDNLQVLSTFSSSTSWLDRIHTCPVGVLDLLNTRACRSAIMFNDELSEEQCRILVKRLAECSFPFMCAHGRPSMVPLAKLSTLGFNQDSSQIWNSKGFLPTLSLGAQFKKWKRQRYCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2T4</accession>
    <name>A0A0B1P2T4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative high-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003387">
        <property type="protein sequence ID" value="KHJ30974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2T4"/>
    <dbReference type="STRING" id="52586.A0A0B1P2T4"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="GCYRIPV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="536" mass="58764" checksum="9321C4B82BDC167E" modified="2015-03-04" version="1">MGLALRKPQDVPGRSWPAIVIGFFVATGGVLYGYDTGNISGILAMRYFKDQFSTGHKSIQDGVLQPDITSSQESLIVSILSAGTFLGALLAAQIADRIGRRWSLIASSWVFISGVILQTIATALPMFIAGRFFAGSGVGLISALIPLYQSETAPKWIRGVVVGSYQFAITVGLLVAAVVDNACKDRNDSGSYRIPVGVQFIWVLTLMIGMLILPETPRYLVRSGNTEEAAKVIAKIRRLSIDHFAVREDLDEISKKYVEELSLGKATYSDCIKGGMAKRLLTGCLLQGLQQLSGINFIFYYGTKYFENSGITDPYVITLITSTVNLCSSPPGLYAIDKFGRRPLLLWGAIGMCVSQFLVAILGTTTTGQTADGVVFATNITGQKASIAFICLYIFFFSTTWGPIAWVVTGEIFPLRVRAKALSITTATNWLLNWAIAYSTPYLVNYGSGNLNLQSKIFFIWFGCCCLSVIFVWFLIYETKGLTLEQIDTMYQEVSIASKSHLWKPKSDQLDNSNIESEDDPRTEALPIEESINHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2U5</accession>
    <name>A0A0B1P2U5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative endoplasmic reticulum vesicle protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001668">
        <property type="protein sequence ID" value="KHJ33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2U5"/>
    <dbReference type="STRING" id="52586.A0A0B1P2U5"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OMA" id="DVFEACF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080436" evidence="9">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="24667" checksum="ED37ECBC6D32E4C9" modified="2015-03-04" version="1">MRVVQRLLSKILCVLLSLNFVLALKFDLEAHPKGSEKQRCIRNFVPKDTLVVVTAVVSGTKGDGMIVNIHVHDAFGNEYGKPKDVVGEKKMAFTSHIDASFDVCFTNQLTGAASVSKPFRHVELTIDIGADAKDWAAVQSTEKLKPVETELRRIEETVGEIVAEMEYLRSREQKLRDTNESTNTRVKWFAFSSMGMLISLGIWQIFYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P382</accession>
    <name>A0A0B1P382_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal ion transporter metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002948">
        <property type="protein sequence ID" value="KHJ31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P382"/>
    <dbReference type="STRING" id="52586.A0A0B1P382"/>
    <dbReference type="HOGENOM" id="CLU_020088_4_1_1"/>
    <dbReference type="OMA" id="AQNCKKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="604" mass="65588" checksum="B67191727120BBE5" modified="2015-03-04" version="1">MNCPSRTDDLDNDMYNQNPSPLTSDLTVREDFNGRVNSTKISRFIGRSDNKIKKTYQKFDDQPRSNGDNADMKFGRMGGVGDESSRGGASLVDGNGVRDGNSGNDNKNNGEIRSSQGTLRGTGDDGKRSELMNRFLSFVAICKKFSKFIGPGFMVSVAYIDPGNYSTGVVAGATYRYKLLFAGLMSNVFAIFLQILCIKLGSVTGLNLAEACRSFLPKWLNYFLYVLAELAIIATDLAEVIGTAIAINLLIPKIPLIIGCALSIIDVLFILLFYNPNGSMKGLRAFEFFVTCLVLGVVVCFCLQLSLIRNSSLGEILRGYLPSKELTESTGLYQACGILGATVMPHSLYLGSGLVQPRLQEYDINHGIISAPIDSNARDKEAYKPSLQAIRGCLKMFVVELTLSLFIFALFVNSAILITAGASLYGTDVDDADLFGIHRLLSTSLSPMAGTVFALALLLSGLSAGIVGTISGQMVSEGALNWTIRPWLRRLITRTISIAPSILVAAAVGKQGLNDVLNASQVVLSVVLPFITAPIIFFTCRNRYMTVQTFQSDDNGRLIDGEESPLIIETKMANHWWTTTFAVIIWLIIAIMNVANLVLLGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P398</accession>
    <name>A0A0B1P398_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative subunit of the n-terminal acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001841">
        <property type="protein sequence ID" value="KHJ32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P398"/>
    <dbReference type="STRING" id="52586.A0A0B1P398"/>
    <dbReference type="HOGENOM" id="CLU_006686_1_1_1"/>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="765" mass="88175" checksum="5B06054C5B8816B4" modified="2015-03-04" version="1">MPQELSAKEQSLFRTVVRNYEDKQYKKGLKTADQILRKTPKHGDTLAMKALIMNSQGKTADAFALAKVALQCDMKSHVCWHVYGLLYRTAKNFEEAIKAYKFALKLEPESQQIQRDLALLQIQMRDYQGYIVSRTAMVKSRPGFRVNWTALAVAHHLNGDPNEAERVLTSYEDTLKIPSSCTDIEHSEAILYKNTLIAEQGEFQRALDHLNTAGKSCLDRLAVLELRANYLTKLGLKQDAIKTYRILLDRNSEYKTYYDSLIKVMEIEPSNHTALKAIYDEYAEKYPRCDAARRLPLDFLEGDDFREAADKYLNRMLDKGVPSTFANLKQLYSNTEKRDILAELALKYLTKYESQVNSQSDSDGNILKCVTAACYFLAQHFNYHLNRDLEKAMKYIEKAIELDSQSVNFYMTKARIYKHLGDVAKASEVMEHARTLDERDRHINTKAAKYQLRNNESEKAIKIMGLFTRADTVGGPLADLHDMQCMWYLIEDGESYARQGKIGLALKRFTSIYNIFDVWHEDQFDFHSFSLRKGQIRSYIDMIRWEDKLREHPFYSRAALSAVKIYIDLYDRPLASRVNGNIENGHDPTEKKKAAKKAMKEHLKAEREAAAKKSAPNKPTGVRSEDSKKIDDDPNGTKLAATTEPLNDAMKFLCPLLQLRQKSIDVQAAGFEIYIRKKKYFLALRCLLKEINLDEDHPNVHQQILRFKVAFESDMGSISSKVVEFIKSEFMCFLDGINLTENNEQYLVKNKDQIKRIISDLKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J3</accession>
    <name>A0A0B1P3J3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative microtubule associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001802">
        <property type="protein sequence ID" value="KHJ32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P3J3"/>
    <dbReference type="HOGENOM" id="CLU_002168_1_0_1"/>
    <dbReference type="OMA" id="FIAVYQH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1317"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1424"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="170"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="523"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="658"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="785"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="857"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1439"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1449" mass="168733" checksum="946AC562AD74F478" modified="2015-03-04" version="1">MVHAGIRGLDTPQTNLDDATYISGRHPEFDLSDEQSFEVPPKENNILEYKLQNIRRSRSNLRTPSNLPSLTNRTNLPGLGGGEFTPLLKNATRNSALRNEVRTPAFLKKRSLNSIHENLSPLPTSNTIESASRNYGPFISTPATQLNVSSTVSTPTLQKPSKSEKSHILHDGAQLSLREQEEAIDRIEKENFALKLKIFFLEEALLKAGPEYNEAALKENTELKVDKVTLQKELIRFRKTLHAAERDVELYRQQLIELQEKYKQNQMDDNAREEITELRRTLEDKDNEITGMKHKSVQIDNLQDRIHNLEAEIRRKELSLDDRDDKIEDLRQEATEREEKLHEAEMAISEAQSKIGELEKKSHAFNELKQSKEKIRNLESKISEMTREIERTKNDQQNALRRREQAEADIERLQDEIANKSFSAKSLNRQVEERVNRTQEELEKLREEYSSLHEKYLEKVEESNELNVKFNNLKSKTKTKKHDLKEKIEILIKEKADVVHEKDSISTKFESNLIEFHALIEKSKALEIENDDLGEKLSNLQRDLEASRSKIVEIEETLARERISATQSEQELKDRYQNEVNVLSNKIEDIQAQLERKERMSRDESEKWANDKRSLQAQKDLIEEKALGLQHSIDKLQESEGTLSSKEAKIKQTLKIETDRHNEQEAILNRQINELNEDIKIRQQNLVETQHELTVIKEELRLSQREQKQLEEKVEGLEDEIEVLQTNLDEETEAFNKEITATKKENEELLLQITSIKSDLTKARSMASNVQKETEESHINGERSREQLISLVKNSEEKLNNLRLEKKDLEDQLNKVNLEINSLRASKASLEIENFKIKDQLSSLQDLKEIPKFDQDRMNLKSSKQKLELEVLRLQEENNAANAERENAENQLDIKIIDMQNIEARLNTEIKNLQKKVKSSTDKRELAIAKMKILQLETRINELENHLNGSDSTDEEDNKEFSLIYRSLKESQEKETEYIQREADYKDVIRGLKLKIFELERKVHNTEISRFQNKSLESSPSIGNSKLKEELVELRAQLVSAHKNTKELRTQLKGAERDAQRKIKASNLDLEMRNQNLEAEKHNLGRSLEQVQLAKEELQIRNRTVESTILRLREKIERLEKALQAERLNSGENRTMVLERKDLHDMLRESQSQVEELDLLVRERDQSISNLTAIENELRTQLEILRGERSQLRKKCSSYHAQIEELQSQFGQAKAQWEIDRRNLTRRVRFANLSLSLQDSNNNDNDNYNHVNNNNENFDSNINLDECSIPQISKQQQNNHNLPPKLLKMKSEFDEREKNLVKQMRGVNLQLEWLRAKCQREEHFRAEAAFAKRFMGLQIALFEACNKADIQLLEKCGIKRPPPRPKKPMSLKRIGIVLRAMIRMKRAAERWAEKRKIDEKVRGQVEKQRKHLLHEIASKCSKEPANINTITTTSSSSSTKKRSSKSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3M8</accession>
    <name>A0A0B1P3M8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative kh domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001766">
        <property type="protein sequence ID" value="KHJ32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3M8"/>
    <dbReference type="STRING" id="52586.A0A0B1P3M8"/>
    <dbReference type="HOGENOM" id="CLU_025201_0_0_1"/>
    <dbReference type="OMA" id="QNTTGCK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="293"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="401"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="567" mass="61653" checksum="1D97FE97B085FB13" modified="2015-03-04" version="1">MAEQPSISSILAALAAQRPSPISSVPTQPPYQQPPQPLPNSYGHSVGFSLPQPTNSGSLDLSSIKPVNSGSVSITDAIAKAREIAAQKGVSYDRPSNYPPQQDHRLSNGRLYGSSRSRSRSPPARRDVFRDSLNPYRDERRIDRNTAGRDYRERSFSPGPRGRVQSGGFSPVHNSSFTGQDRSSPRGFDDNSESLSIETNLVGLIIGRSGENLRRVEADSGCRVQFITGPEEAGPFRQCRISGTRASRMKAKAEINRIIDESGMVANARAAAERMKELPPGRSFSHQPALRDGEDSMQIMVPDKTVGLIIGRGGETIRDLQERSGCHVNIVGEQKSVNGLRPVNLIGSREAADRAKDLIMEIVESDSKTSSGKDRVLNQRDHHRDSGIGGSSNGYNIPGGEKISESIFVPSDAVGMIIGKGGETIKDIQSTTACKINVSPQSGPGEVEREIGLVGTRDSIIAARRAIEEKVEAAQKNGSNRARGATHNDFGDRNYHQYQHNQQHNQAALIQSSTIPGAEDPYAAYGGYQNYLALWYQAIAQQQQQQQQQQPQVAQSQRDLNKPPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3R6</accession>
    <name>A0A0B1P3R6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001720">
        <property type="protein sequence ID" value="KHJ32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3R6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3R6"/>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="389"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="569" mass="64049" checksum="A65E165EAC5AED64" modified="2015-03-04" version="1">MQKIDQSDIFGATSGENQNKESFDNIYLDLSKVSGKCRFAETGLGWKPSGGGEAFTLDHTNIGAAQWSRAAKGYELKILLRNSGLVQLDGFSHEDYDRLSKIFKNWYSTNLQHKEHALCGWNWGKGEFGKAELAFNVQNRPAFEIPYSEISNTNLAGKNEVALEFTLPANGHDNVNGSLGGANSKGRRAGAGKDQLVEMRFYIPGVTTKKATSDGEETGSGGEEQNAANLFYDTLMDKAEIGEVAGDTFATFLDVLHLTPRGRFDIDMYENSFRLRGKTYDYKIQYDTLKKFMILPKPDEMHYMICIGLDPPLRQGQTRYPFLVMQFKKDEEVTIDLNMTEEMMKDKYNGRLAPHYEQPLHQVVTHVFRGLTGKKVNQPAQGFTSHHGQYGIKCSIKASEGFLYCLEKAFMFVPKPATFIQFDHIDRIVLSRIGGAISASRTFDITVKMKEGTESQFSNINREEQSQLEEFFKIKNLKTINEMDDDGNALLAAALRDPDMASSDDEEIVARSNRDSEDDEDESVDEDFKTDTESDVAEEYDSAHESVESGSEKEDKEKNERPKKKARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3U0</accession>
    <name>A0A0B1P3U0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative serine threonine-protein kinase mak protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001702">
        <property type="protein sequence ID" value="KHJ32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3U0"/>
    <dbReference type="STRING" id="52586.A0A0B1P3U0"/>
    <dbReference type="HOGENOM" id="CLU_011172_0_0_1"/>
    <dbReference type="OMA" id="GNWYNKA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="770" mass="85308" checksum="426C3EB8C7B1B0E4" modified="2015-03-04" version="1">MSSNLALEDRFEILKEIGDGSFGSVSLARVRTAGSNVARRGTVIAIKTMKKDFESYAMCLELREVVFLTTLPNHIHLVPALDIFLDPFTKKLHIAMEYMEGNLYQLMKAREHKCLDVSSVKSILFQILQGLEHIHAHHFFHRDIKPENILVSTSGHQDTGSSFRRYSTLMTPPSTPPAYTVKIADFGLARETHSKLSYTTYVSTRWYRAPEVLLRAGEYSSPVDIWAIGAMAVEIATLKPLFPGANEVDQVWRICEIMGSPGNWYNKSGFQIGGGEWKDGTRLANKLGFSFPKMAPHSIDHILQSPQWPTSFSNLVTWCLKWDPKSRPTSSQALAHEFLVDAFDPIRTKTTSPKVLGRKQSDSGNRSNKEANEANNHGSKSSWFRKSLIGRSESCIDPNQNLTKEAQPPRVSPAHTIEISVLKTRPHHSKRSTWNNGPSGFAPIAILPTIKPISPLSDTVTAQANNRSPSCYENYSTTNRNSIIDDQTGKRNGRHLSIASGNNHYAEIHRQEAEMALNGNTSLASPSSGQKESFFSHLRKRARRFSGRQSQIPITPKSMDFESHVGCGPWASNRSSMLVDGTQSVSPIHKVDTYEALDRALRNVQQNLDASTNGIIPAPINNNITTQNSVLKRHHSLPHQVKSADNLRGPGLISSRTRRSQIPHGTCQYETPAEEDELVDEVLRNTSSVITGMRQSYVSNDFRPIRQSTSNLCLGNPYPTPSPSANGNNHLSQGLISSCGKISQSTQLDDDENEWATAAAASILAASTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P444</accession>
    <name>A0A0B1P444_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002656">
        <property type="protein sequence ID" value="KHJ31691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P444"/>
    <dbReference type="STRING" id="52586.A0A0B1P444"/>
    <dbReference type="HOGENOM" id="CLU_1042791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="267" mass="30826" checksum="4BE02E533086AAAD" modified="2015-03-04" version="1">MTSQHVWNMLRLCWIDVYLGSPDIITHDAGSNFSSKEFRQTAKSLAIEIKEIPVKSANSMSIVERYHKPLRLAYEIIKEEIDTNNTEEQKSFVLQMAVKAAYTQSKSHLAREFYVRPPKELKLPAETLLKVLRPLYGVPEAGTHWFRTYHDHHIYNLDLEPSSYDPCLLFSHEAIVGLQTDDTIAACNTEFRHKEEEELQRAKFDAMPIQKLTINSPININGAHISLLDTTISVTQHDQISKISILKDYSKHDYVSQRARGDRIWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4B8</accession>
    <name>A0A0B1P4B8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001372">
        <property type="protein sequence ID" value="KHJ33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4B8"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="179" mass="19991" checksum="15BA2B2A72A969D3" modified="2015-03-04" version="1">MINCTGKIKLRRHIELDGVFSKAPLAGFRIFDESGIGRPFKKQKPIEFCEICNGYLHIKNCSRVPSCGNCGSTNHTENLCIAATKCTNYGGPHRSDSLRCLARSTRSDVPTKEHMKTFRQVDEREYQAVLRAKAAERSIPPSENINNDFKSSLESYIDDNIDNIQASPIENPTVGALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4D9</accession>
    <name>A0A0B1P4D9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001360">
        <property type="protein sequence ID" value="KHJ33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4D9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4D9"/>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="OMA" id="AWYRSRC"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="479" mass="55313" checksum="10D3869501D34B62" modified="2015-03-04" version="1">MDRQILPISALPAWALLNNVIFRNVKVEYLSGTKWFGLISENTLRSESAIDLTALVAVPPDVILSAKSVAEYAKLDHYFQQLLESAGGRSRREDIMLYLLMQISIGSLHIKERNFGLSSPWTEYVRMLPAEVTLPTMWRGEELGLLKGTSLEAVLNAKIRALEEEFEFLTEVTRELPWCQKYWWEADKLKLHDWIQLDAWFRSRSLDLPPLGECMAPCIDMVNHSNEPNSYYESTLEGGIALLLRPHVELEPNSEITITYGETKSHAEMLYSYGFIDQESKILSLTIFLQPLDDDPLGKAKLATYPGPPTLQLYCEDGRFEWKCSFVYFMCLNEEDGLEFKVLQQNDGYQSCLQVFWQNLDVTDKTDDFKLLIADHPLLKVFELRVVTILHQQVEQQIKRLNHGDEIIEQLKTGNLFPRHKMYATQLRESERYILEQSLESLIKQKNNLLENYTVKEYLSPMATSTQELDISDDESDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4H6</accession>
    <name>A0A0B1P4H6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002755">
        <property type="protein sequence ID" value="KHJ31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4H6"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="OMA" id="QREHIRM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="195" mass="21551" checksum="36804C1A3EE40B08" modified="2015-03-04" version="1">MLTDEVERVCSMRPAYVKLYGRNKSEAPHRTWMAYFPEAPRTGFRVFDESGIARPFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGSTNHSQDLCMATTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMKAFRQAGEREFQAVLRAKAAEDSATSAEDFSVGKISSQTTEVDANANIITASPVDSSMGDVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4T3</accession>
    <name>A0A0B1P4T3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001537">
        <property type="protein sequence ID" value="KHJ33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4T3"/>
    <dbReference type="STRING" id="52586.A0A0B1P4T3"/>
    <dbReference type="HOGENOM" id="CLU_025402_2_0_1"/>
    <dbReference type="OMA" id="IGQPWGS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="547" mass="61036" checksum="2B7AF808E4514AC3" modified="2015-03-04" version="1">MSQRLSPFLFPGSVATANQLAIIHLKRDLQIPVILREHDEDDEGYAEGKVLNTRFGNFPHSTLIGLPWGSQVRASKVDTGSRGRRTNVNELKRKRDNAGATDLSSDKIKDKNAHKGGPEADVLSPVVKVEKEAVTASTGFVHILPPTPENWTSSLPHRTQVVYTPDYSYILHRLRARPGSRLIEAGAGSGSFTHASARAVFNGYPEIDRTVANDSLSEGCKFGKVWSYEFHEQRYEKLQKEIEDHGLESIVEIVSRDVCTEGFLINVQATNSNDDLELKAENNLNGPAAHLNNSENLTKARKSPLASAVFLDLPAPWLALPHLTRSPYTLSNFKQLPLAPKPSNTSSNSFISALDPSVPVHICTFSPCIEQVQRTVSSMRRLGWVDIEIVELSQKRHEIRRERIGLSIKGAQRGQQVTPVNVEEAVARLLEVEKTTKAYQERGTNAISSDKLVAKGEPDDEIPIESKHYKENPSRRENFIKNLVENKSYKDGRLVHRTEAEVKTHTSYLVFAVLPQEWSEEDELIAREKWPTPLGTDNGVINVKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P536</accession>
    <name>A0A0B1P536_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ph domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P536"/>
    <dbReference type="STRING" id="52586.A0A0B1P536"/>
    <dbReference type="HOGENOM" id="CLU_006465_1_0_1"/>
    <dbReference type="OMA" id="MSWYEDI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="366"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="747" mass="84344" checksum="EC1A4A7509E58C2E" modified="2015-03-04" version="1">MAISQPVGRFNEEWDASQRGTSILSEPIQKSSSAILQECRPLSSRESTLAKASSNRGNTNKKPSSRRSSRAGSVRSLVHQLSYGIDEKDSIFFSPIPTNGNPTDLLAARFQAWRKVLKDIITYFREIQASYDLKAKSLQKVFNIFSNTAPCSVFLQSNGIYDATCALQKYYKASICEANKSKDIENEVIFTLVGLRSDLQQKIKEIRNLSGDFRNSLEREMESTRKAVNELQESLGLTDLDSLHVTGKRDPYLLKLATDHLVEKQIAEENYLHQAYLNLEASGRELEGIIVGEIQKSYNAFANILRREVEVANYTIEELHLGPIAMPKDHEWNNFIRETDNFVDPNAPMRYSQNIKYPGKNDELVQEIRAGLLERKSKYLKSYTAGWYVLTPTHLHEFKSIDKSQAPIMSLNLSEQKLKLFSKSQSASDKFVLVGRQTGVMHRGHSWVFRCESYESMMSWYETLKSLIDKSPEERNTRARKHVRTSSGASQTARSICSSDGGLEDEDEEPFSSEKSAIEAGSFNPDTLPMRPHAGGRFPSTDLLLNKPHQRDVSQQEANLLHSQSSESSSNGDTQNLSPKIHENFSGDFKSYPDKNFPDKQAETLNNSIKYQVSYNQTSIRQLELYDKKIQLSILEESPVPSKTTRTLSAEIDNIEVRDENLDDGILRNSDTFDYTSAKSDVSLEHVKNEAPQTSSAPRVESEVQSKPTVLSSMTGNIIRTESSPYVPGEWLNENYLKDKAIGVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Y4</accession>
    <name>A0A0B1P5Y4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative wd repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001848">
        <property type="protein sequence ID" value="KHJ32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P5Y4"/>
    <dbReference type="HOGENOM" id="CLU_002093_0_0_1"/>
    <dbReference type="OMA" id="ATSWGTD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1853" mass="209606" checksum="39B2D230F5CB3CB7" modified="2015-03-04" version="1">MDVPWLESLTEDWITPQNSIKSSETLISCSDSISDGSQSNSCRKPEDILNKIQSNDIKSSRIVDERHLNLTKTPRSNPSSKYSEKLLHESNLSGSDQFWSQTTSISSSQPDTINYNKSTRPVSSNPQETLEWKKRILQGDIKQCDLFSPSNLEIIFTNPSTNTKTITKTKLTAHDDSNLHLKPKNLNDLQIGYTEKDEKNKSLKSFEEGLHPKVMKESNDVSNTVNKEPSDIDSINSKLNNIVLDDEITIKKNTSLPLTTKSINESDVNGSRTISGQSISKNEQLSQIILVKQSTEDGRISFTPTDLSFDRIRKKIKPCKKMILTSSLENQDSVSKTLSDNLATNGYNVTQENSLDQIQEAKCSQDFISKNADLLKSQSLPDESALLPEESMQASTPKDLSSGKVTHVTGNQELTKTKPMVSSTPHSSPTRPQQNDVKKTSHSPLKIFDKHDTFTNEKLLRRLSQFECELADPNNSILISQTSPKLTKIQPSKESEGFIGKLRTGSNQSIIERKSSIFRFGDFNDFQFEKLASHLPLALESCRSDKEVVSPDHLPKIDSIEFSLNLPSSSEGNEQLCQQKFCTDHINTFKRIHSYREISQPLTSPLSSRLSFCSKQDEFSTPRKRNGSCDGKRLPKTPLRHPFCKRRRTLYRIETNDESELSVTSELNSAKIFQKFSQPVLNRKQATCKQGHESQIVKLKQSHAGIKHNIPCSQDVKIKNHSVVETTLNSTKDSSVCGNFMPGANQDSKKAPDLIENNKYSEEQIQIGSRKASVPTNEYIDEAKKIMANLRRRNRSLNALTIVEESDTKINLRNSVQTTSSRDFTDGLYQESSLEPFSRPPSREGAKPIPRPPKEQVDPAIIDHLRKYEENFDVQSILASSQKSIAEVREAFELAKKINRLTEEKIRRNSNRRSTTLTDSVEKIPDVEAFSGEKKDQPITSYMSCDSQISSHGHFQSVKSHASCIRSLTHSIPTGTSKELDNRRVIAPESVSHLIPERLAGMVFLREQNTWVKKKSLGSEKSSSMSFTPEATDDDPFVDISDLSIDETLENERIKIEAAKKIDGAFLSIQRPQINSEQTLKIQSPNIPIKNTIEENVSVLKHSPSKNKGSPQLKCILNQNLQSKTGIFQCIEEENSTCDERIQLDQTPKEKPKRNITVSFSSPMVSFIETQEYQNRFSFNHDKNPAGQSLQNLDKPDTKRKSYSEEELNRRLPTTSHLLSPVATPVKPSIDDHHFTPQPISRIDERNKNMENTLDHNQNNRSFSIVFTKSIAPNHMSKTLTTPRPLHEIGTLTLTPLSDFTINQVDQTLGLDVSYLAQPRFSQVENTKKTLSSIIRELVEKITEAEPYEPHWEHLREINLKGKRLKSVHKLDNFCQRLKELDISNNQISHLDGVPRTVQNIRINDNCLSDLTAWGHLTNLQYIDVSNNNLESLSSLKCLVHLRSLRADNNKITSLDGIDQLNGLLTLRMRNNYVRNLNFQKSNLKLLIELDLRNNQVCNFENIHQLSSLTHLDLVDNNLTEFSINGPITMKSLKYIRLCGNKLESIYVGCFPNLRLLYLDRNHLGRVMGMLKTKYLDSLSLREQCGSALHPSVISEAFEVRKLFLSGNFISKLQIESDFLNLQYLELANCGLESLPEGFGSMLANVRVMNLNFNALTDIQPISGILRLKKLYLAGNRLTRLGSLTKLLFQVPTLSTIDLRGNPLTMGFHSPILMGGAVYSEEADSDGMQSRKPYTLGKIDKIKDSQYVSCLDMRTRMKRRIYEINLIRSALRLKVLDGLLIDRSVLFTKDKVYDCMVEAGFVAHSNIDIKSPQNVNILQNIDPSYYMRKEIDTIQTSPEIVNDEIWQAEDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P612</accession>
    <name>A0A0B1P612_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf1295 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002325">
        <property type="protein sequence ID" value="KHJ32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P612"/>
    <dbReference type="HOGENOM" id="CLU_043418_0_1_1"/>
    <dbReference type="OMA" id="WRKGGYQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="340" mass="39338" checksum="B6C4A5C8ADA2E64B" modified="2015-03-04" version="1">MALPIVGSLKDCCSFEQTVTRYISQLYEFPSHVINTWHSPASLGNLYLATNPFIGGLIFSLFVAFALYLVSEVNGNVSLIDQSWSILPSIYNIHYVTYARLSGLNTKRLEVLVFVSVIWSIRLTYNFYRKGGYSKGSDDYRWDILRKMISPSLFVVFNIIFISLIQSLLLFLITAPTYLMLLVTPFTESITVADYVFASVLLALIVYEYIADQQQWHYQVAKKIYNETARVTREYTQQDLERGFVVTGLWSKSRHPNFLAEQAIWVVFYVWGSWTSHKYINWSSVGVISYLILFQGSTSFTEKITAAKYREYKEYQKSVRKFIPNFSSTYYGHALKEKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P648</accession>
    <name>A0A0B1P648_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pi-transporter a-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002284">
        <property type="protein sequence ID" value="KHJ32154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P648"/>
    <dbReference type="STRING" id="52586.A0A0B1P648"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_13_1"/>
    <dbReference type="OMA" id="PDGVYWA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="80"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="633" mass="72213" checksum="207D1B06B7672286" modified="2015-03-04" version="1">MKTEALPTVATNKEDEILREILFPDDLYTPEGVYWADLPLLKRIAFVNRKSDEEAKKEFTSFWSMFKKDPLSPLAWYFKNAVLPGAGLGLEGYVLFSIGNLSPFFETIWPQCWRTHEVCSKNWIHAVTYLEVLGIIVGQILVGIMGDALGRRWGLIHDAAVMFLGLVMLTASWGASLNGWVIFYAWSLFIYGIGVGGEYPMTATAAMENSTTGRVADREDRLHRGRKVTMAFLMQGWGQFFNVGILILSLLIFNGGAQLPYSVVAAQWTFRVSFALPAIGTLWLVYHRWFKLPLASKELQAARTNSHVTGYDVQSLKMTFRHFGGRIIGTAGTWFCNDVFFYGNKLFQSAFISVIEPDALRSGNVITGWKWSIVNVSVSMVGYYLATFLIDHKLYGRKWMQQVGFAMCFILFVVPEFNYDYYRSIEHIKEFQVMFFMSSFFNQCGPNSVTFLIAAEVYPEAVRASAHGFSAAIGKAGALLASVLYHYIDDQTKFHVVPWFGLAGMLLTWLFVPDTTGLDLSEQERRWTFIRAGKESEYHGIAIHSKHLSVWERICGTGKNYDPLLDRISRKEQLRENWEKSEQEKVYKEDGMSKYEEFSESVNTFFRENRDISSIESYAAADEKRSPIRDNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P663</accession>
    <name>A0A0B1P663_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002274">
        <property type="protein sequence ID" value="KHJ32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P663"/>
    <dbReference type="STRING" id="52586.A0A0B1P663"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34348" checksum="A4BCC763E2BC85D1" modified="2015-03-04" version="1">MTSSTFDSCLLYNSEALIGLQIDDTLIAATPKFMEIESRELNKAGFAAKPCEKLTTNKPINFNGFKITLQHDGALSISQHKQIMKIKLLDSSFTKEQYIEQRARGAYIATVSQPQASFNLSHAAQITQPTNKDAETLKRCLSWQLKAGGLRFVQLDQKSLRLITFTDSSFANNDDLTSQIGYVIALADAQNRANILHWKSVKCRRVTRSVLASELYAMSLGFDVAATIRSSLNQILSSNVSLTICVDSKSLYDCLVKLGTTHEKRLMVDILAIRQSYERREIADILWIKGNKNPADAMTKEKACNALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C1</accession>
    <name>A0A0B1P7C1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative signal peptide protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001006">
        <property type="protein sequence ID" value="KHJ34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P7C1"/>
    <dbReference type="MEROPS" id="A22.008"/>
    <dbReference type="HOGENOM" id="CLU_023799_1_1_1"/>
    <dbReference type="OMA" id="TFWTGTL"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="553" mass="62258" checksum="6F5D71CEE932AF47" modified="2015-03-04" version="1">MDNRFIQFQGESPLLQSIREWAYLLTKERALLLMYVHIIVAALFPIFTGSHASLRCPPSAKVSKKFKKLKIEEEEDELDEYSPDIQGLKPSDAILFPVMAGIILGGLYLLIKWLDDPKLLSKVLNWYFSGIGVIGVGKLTVDILNVIISFVFPRLWSTKNEIYFIDAINLYQLTESSSESGTNLVSVKSIKDVSNPLPGFMSIIPFPSSLSSKIWYTRALFKNHLIFRGYIKNLMRIAVPIRLTHVIGYTFGLIVIILYNFLARPWWLTNLIAFGFCYSTLQLMSPTTFWTGTLVLSGLFIYDITMVFYTPLMVTVASSLDVPIKLVFPGPKKGSMLGLGDVVLPGIMIALALRFDLYLHYLKKQRALKSPPNPNETAVVKPDYIEATGAWGEKFWTSSLEHKSSYQTIADGARFKKVYFWTSLLGYVLGLVVTLFVLKVFNHAQPALLYLVPGVLLSLWGTAWARGEIKTMYDYTEDGDIGLNSKENRSNEKSTSPQNDVINEFKKNENVISKDEASVNAVESLAASYKAKNNEKDASHNRILMFSLTIPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7C4</accession>
    <name>A0A0B1P7C4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001552">
        <property type="protein sequence ID" value="KHJ33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7C4"/>
    <dbReference type="HOGENOM" id="CLU_096592_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="27731" checksum="D6F7F8F699B4CA9E" modified="2015-03-04" version="1">MNCSRAPSCGNCGSSNHTKDNCLAATKCRNCGGPHRSDSRKCLARPTRSGAPTKEQMGIYRQAGDREYQAVLRARAAEENAVSIENMNAELTSSQLQENTKTTDNIQASHVEDSTRDARSLFNGNIFLNVYKAPHDPSAVQSLLDWKPTLKTIAIGDFNSVYWAWKPSANSYYGQGEEIERWAEKYNLTCLIVGEPTHRVGNTLDLVFTNISETMAWAGTEECMTNDHLPICGFVPNHKASSASLPTPKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7F4</accession>
    <name>A0A0B1P7F4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001784">
        <property type="protein sequence ID" value="KHJ32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7F4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7F4"/>
    <dbReference type="HOGENOM" id="CLU_008279_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="59"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="678"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="765" mass="85011" checksum="38273DEC50EDB48C" modified="2015-03-04" version="1">MSGLFNKLKGAASGSSTLASSSPSLRKKEVEPDPEVSILVKMLHNAGPNIRKDGSDKFFGMENFGNTCYCNSIVQALYHSIPFRENVMSYPPRSTSEILDDSTKTVPSIRSIIQNGPASALNSKSKALTAAETAKKRAAISAGQTVSTSTGQRPEDKPDSPEYKKKQALTCGPVLELTYDNSKSYGMKESTFTTLKDIFMALIESKSRTGVLSPQRFLEIFRKENETFRTSMHQDAHEFYGLVLNSVITNVEAKAQELKDVSPKSPSTLDSSIECSPSSVVNTMSLGNGVRTPGTSWVHEIFEGVLTSETKCLTCETVSQRDETFLDLSIDLDEHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAERRMKIKRLPKILALHLKRFKYTEDMTQLQKLFHRVVYPYHLRMFNTTDDVEDPDRLYELYAVVVHIGGNAYHGHYVSVIKTQDRGWLLFDDEMVEPVDKHYAQNFFGDKPGMACAYVLFYQETSVEIMRKEQEAEGLSGVPGTWGIEQISHDLGDSILKNTSQYSPKSKLVDVYTGSQEIKESSPQKDTPAVPPVSLKSSYSFATVTHSSSYNSPTTSPLSSQIPNLLPSVHSKMTNKDQKALEKKENKEIEKARKANKKALLKERKLQAKDQKKGVSNRVGTMLDEEGPLEKVEDGKAHSTASIEPINGQHEKSCSIRSKQGSRSIGRKGLAFLGGTRANDSKRTPITTNKETNGDNTNDGFEDDQTMENQSSKSTKERFGFITLGRKKSTLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P816</accession>
    <name>A0A0B1P816_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative origin recognition complex subunit orc5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001386">
        <property type="protein sequence ID" value="KHJ33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P816"/>
    <dbReference type="STRING" id="52586.A0A0B1P816"/>
    <dbReference type="HOGENOM" id="CLU_028223_2_0_1"/>
    <dbReference type="OMA" id="QLRRWHG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="352"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="521" mass="58289" checksum="202B862FD949C570" modified="2015-03-04" version="1">MNSALEIPSTNLSNVSSLFPCRERQIQALKTLISINGASNRNIIVHGLAATGKTVITKAILEEVARFYQSGCDRDESTSSVKSDNSKYDNIPQDIFSYAFVNNEECIDVRQLFEHTIGSICHALNVENNNSGLLANISDFLVQIQKLLESWVGDRKNVYMEKRFILVLDGIDKQIRNGFFPQSLPAALTRIGDFVPNLTIVYITTYPRTSFLNFPGIPCIFFQSYTKSELLKIILLTKPIPPLSSPEDTFQIWSRFTSSVYDSLSKHSGRDLLSFRTLCLRLWPVFIHPILSDEIDVNSFSRLMVVNRSLFQNDYVLVHDIISPSSKVNNQTNEITAIINQKSQHTSIADLLPTYSRLLLIACYIASFSPVRNDTVTFTKSSTAKRRRKGYGLASTSSASGVVKSRKIPRKLLGAQGFVLERMLAIFHALCADSDFIVESDEKNFLNNHEAIHSQLVINGNANVQTAIATLVSLRLLTRTGNPNISDILDASIKYRVTIGWDMVRSLARSVGIEIENYLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P824</accession>
    <name>A0A0B1P824_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative e set</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001821">
        <property type="protein sequence ID" value="KHJ32779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P824"/>
    <dbReference type="STRING" id="52586.A0A0B1P824"/>
    <dbReference type="HOGENOM" id="CLU_016622_2_0_1"/>
    <dbReference type="OMA" id="ENTECFI"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="419" mass="47478" checksum="6AE2828873311254" modified="2015-03-04" version="1">MPVSIDLDDPYSIRTNHDIVSGHVNLYVKTAIKVFTIFIKLKGESRSQIVPSSNSNAARGRPVIESHKILYQSQKLFPEDRLGLFLHPPRKLKAGRHKFKFNFQIPLETDCKDQRQVLPDINYDLVSSREDVQCDHIKQILPPSLIGLPGLAEINYYIKVTVRCSPIFRDSLRSIFRFRFLPLTPPGITRSENIFTATRIPFKFQEKIISNTKDLNKSEREATDITPIGELLVRFPQPAILISSEHLPLELSIRKLNKCSKQLFLVSFSLHIISQVKAIANRMEKINSSTWVFANLCGLSIEIGSVNDNENTECFISQNLWCHLQIPSNIGPSFQTCNISRSYELDIRVGLGFGTTKNIQPQTIFLSLRLPIEIYSGVPRSTIRDFITSPATVLATPQSMLTLENDTPPPSYESSFATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P832</accession>
    <name>A0A0B1P832_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P832"/>
    <dbReference type="STRING" id="52586.A0A0B1P832"/>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="MGKKVWH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="226"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="353" mass="39089" checksum="D1187CAB8B56A571" modified="2015-03-04" version="1">MFKKISYLPKKAKGTRFLLPSNRREFQYSNSKYTNYGLIGLGQMGFNMAKNLRSNLSASDSLYIFDVNHEPMNRFIRETKDFKNGPIVYQAINVSEAADNSKVIITVLPDSPPVKEVYQQIFSKQPLYHSNNSNNKGKPQNRLFIDCSTIDPITSKEIAQLAQQREEGTSYYVDAPISGGVIAAMQSSLTFMLGCPDNLVSQITPILQKMGGKQVIHCGPQSLGLVGKLANNYLLAISNIATAEAMRLGMKWGLDAGLLSHLINQSTGRCWPSAVNNPVKGVVAHAPASRDYVGGFSLGLMKKDLSLAIISAKEVGIQLDLAERAREVYEDADTFENCKGRDFSVIYRYLEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P848</accession>
    <name>A0A0B1P848_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000640">
        <property type="protein sequence ID" value="KHJ34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P848"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="35861" checksum="5C563ED87981BEFE" modified="2015-03-04" version="1">MTDSMDINKETQAHKPPPIPPVPPIPNSPSSTAPFTPPSNSAISNTTIDGRQILKPVAPSKRPITERPTSDSSDKSAFRNAFFPKELADIIAIRQRRERTWHARLLICTTIISSIDSTLANFQDEIEKEEVVAFKAHLRQAIASFAAIDSSPSPPRVPVHTRPNKGGRNSNGKGKDIDKISTKKVAVATPKIILTQGSNLGSSKEVELPRIIPSSDKSWVTVARKGEKKARITYNSHVASGIKVIQDLSQKDKSASIISDKRLFVRLSLEHEWRKLSPAGILEVLDKKLLISPTLIGKFKLDNSGFALSPCSAEAREVILKAGNGFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8D3</accession>
    <name>A0A0B1P8D3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001731">
        <property type="protein sequence ID" value="KHJ32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8D3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8D3"/>
    <dbReference type="HOGENOM" id="CLU_039522_1_0_1"/>
    <dbReference type="OMA" id="KEPENSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="362" mass="41149" checksum="93FEDA87EB1BE9A4" modified="2015-03-04" version="1">MVSLWPWRSEDNSPASFEKILAALATKISKSEIHLENLRSSSRKYKALWTLYTTFLYLFGLVVLVLVVGWKNWTILEGTALAGWPTLIYVGRLTLKTYYNYRIDSVKQLLEEQQTERFKTIEKLKAATKYNTTHELLEKYGQVSSHTISSSPTGKRQEPQKLPRTSIIPPPTANILKLETLSNQEVKSQPRAPTRILNNHVSESRKSVDLTRPGSPEFAPNAFSFSSEYVSTNENIVEGHWYDRILDILLGEDETLPKNRLVLICQHCRLINGQAPPGTKSLENLGKWRCYSCNSMNGEEVKGDEEVKRLIDYAEISHVGPAEVIKEERTGHEPEEVPTAAFQRKSAENLKIKEPENSHPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8N7</accession>
    <name>A0A0B1P8N7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative abc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001287">
        <property type="protein sequence ID" value="KHJ33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8N7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8N7"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="OMA" id="FFQIIPM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="190"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="511"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="761" mass="86696" checksum="2C1B027F875B2086" modified="2015-03-04" version="1">MTGIYLEEDEMFYMTLSCITYLLQAFILVESRHPFWYPYFVTWSFSLLMELKILIIHLIYYSDPQFSMVSLIEQFIRILSFLILFLYNYYLKVHKEYSHLYSIPKLSLSINVGPESISSEIFSDYDLDTNKGNLNKSELLEKEDKSNDSISAYYDGYDGNTGKKSSETGNWIFLPYIWPFREKTLQLRAVLVVFCLMGSSALNILVPRQMGTMIDSLTKYAQGDHTYNIWLPLITYTALRFANGGSGISLLRKWLWNPIEQHSYGALTTASHSHLMNLSSDFHDSKITSDLIQAIFGGRSISLLLEAVFFQIIPMSIDLSLAICYLSSQFGPYMGLILMITIVLYIYTSTKLHAHRAKKRRNFITMFRKQINIGEESLDFWSTASLFNMILYEKSRYVNAVKEHLESKNKYENSSYLVDLSQGLIMALNLLSVLCFGFYQVTYNGKTIGQFTTLLVYWAQLSGPMNFLSTIYKSFVNSMMDAEQLLKLFHTKPTINDLPNSKPLKLKGGFISFDRVSFAYDTRKDTLKNISFAAPSGKTVALVGETGGGKSTILKLIDRFYDVKAGSISIDGQDIRNVTTSSLRESIGFVPQDPILFNDTIMNNIRYAKLSATNEEVFEACKASAIHEKILNFPDGYESKVGDRGIKLSGGEKQRIAIARVILKRPEVILLDEATSSVDTETEKTIHKSLNKIFKDRTTLIVAHRLSTIMDADYIYVVMNGEIIEKGTHKDLILENGKYKKLWSQQVCGRSFLDNNSNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P956</accession>
    <name>A0A0B1P956_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">EV44_g5182</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="JNVN01001399">
        <property type="protein sequence ID" value="KHJ33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P956"/>
    <dbReference type="STRING" id="52586.A0A0B1P956"/>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023347515" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023347516" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="248"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="993"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1072" mass="121403" checksum="D197EEA37BA9B36D" modified="2015-03-04" version="1">MIRIKLSNRFKSVNGSSNITMISKDNDPKLPVRKMDRDNLKCQVKGYGLILKIMVIKARNLAAKDKNGLSDPYLTFTLGDSRHSTYSIAKTLNPSWNVLIQMPISDTNSMVLNCVCWDKDRFKKDYMGEFDLAIDDIFSTNKTELEPKWFPLQNGRALGKKGGTVSGDVQLQLTLFDSTGLSAAPELVLEKLRALTSSAYSSDDNPSSKTPSIGDIQASEDIEEPSDESDRPEPSEKRRRNIKLKGLRKKKSMTGYEFSSGGEVVGIVFLEIHKIIDLPPEKNVTRTSFDMDPFLIASLGKKTQRTRVIRHNLNPVFDEKMIFQVLKHEQTYSFSFTVIDRDKLSGNDFVASTLLPLKALIDRAPEADPKTGLYALNMPEVINSQPNKSRFKLSINRSLSMQELGKISRPRNSNQSFCQPNRSFTAIATSQTQGSAVTPEGQQLSDNIPSLTLEEGYSDSNFHHFTIPLKLKNAEKWDEKHNPQLFINAKYVPYSALRQQFWRSMLRQYDSDESNRISKVELTTMLDTLGSTLKESTIDSWFSRFSNSSNCDETSPELSFDEAVICLEDQILKNPNSATDNNYRNLSTSSFVPHGQVNAYRRTSDLTNSTITEFSDNENNPGHVKSSINEDIKTQTEEGNFLDKDDLNDRGEEHVIEIRECPICHQPRLNKRSDADIVTHIATCASQDWRQVNNIVMGGFVTSSQAQRKWYSKVITKIYYGGYKLGANSANILVQDRITGEIIEERMSVYVRLGIRLLYKGLKSKEMEKKRIRKLLRSLSQKQGVKYDDPTSRAEIPKFISFHQLDMSEVLSPIDSFPNFNEFFFRKLKPGSRPCSAPENPGIVVSPADCRSVVFNRIGDATQIWVKGREFTVERLLGNAYPQYAKNYKNGALGIFRLAPQDYHRFHVPVDGVLEKPKTIEGEYYTVNPMAIRSALDVYGENVRVVIPINSVAHGRVIVICVGAMMVGSTVIVRKEGEHVKRAEELGYFKFGGSTILLLFEEGMMQFDEDLVANSITALETLVRTFLPELSLKFCVANKNNLRLFLSDTCWHARWPYSFSKTNFIRYTIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P972</accession>
    <name>A0A0B1P972_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative rna-rbd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000465">
        <property type="protein sequence ID" value="KHJ35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P972"/>
    <dbReference type="STRING" id="52586.A0A0B1P972"/>
    <dbReference type="HOGENOM" id="CLU_012062_0_0_1"/>
    <dbReference type="OMA" id="AMPNMMN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000466">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein HRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="114"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="198"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="559" mass="61089" checksum="A513FB1604864F0A" modified="2015-03-04" version="1">MAEPDNFEEDLFADLYTEDEAPQKSEIDEPQVVTKPEMTPSTEVKTDRNGHNDQQIMTFEQMFKNRPNVYDKIEHLSGADSGASIGNDSGGNGDNSYESPAANEAHGPGIKEDGKMFIGGLNWETTDQSLKEYFSQFGEVVECMVMRDGVSGRSRGFGFLTFKDARTVNIVMVKEHYLDGKIIDPKRAIPRDEQERTSKIFVGGVSQEATEQDFKEYFMQFGRIVDATLMIDKDTGRPRGFGFVTFDSEAAVDACLSVPLEILGKPIEVKKAQPRGNMKEEDDNRNGRTSRFRKAEDTPSPSQLLPSNNNQMAQSGMTPQLVAQYWQRMQQYMAMMQQSMALGNARGMPVMPGVLNPAMMMQMQAMQQMQNQSNRSQSPQSPSAAMASMSGMNPAMLQQMQAMQAMQMQGMGGSNGGFATNTTSNPAGRIGTPGYSAFEQQVFEQQKYEQQQQLRRGPRDQYSSQGTYSNGIGGGPTSWEGMYDDVPQPNIPAAPSGGARGNHQSSNRSVGRSSVPPPTGPGSAPPANAPTGPKNAGKPGANYRGGGRGGNRGFHPYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P986</accession>
    <name>A0A0B1P986_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative apc13 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g4902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000701">
        <property type="protein sequence ID" value="KHJ34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P986"/>
    <dbReference type="HOGENOM" id="CLU_083683_3_1_1"/>
    <dbReference type="OMA" id="HRPINPE"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="102" mass="11669" checksum="2C4A7475518034F2" modified="2015-03-04" version="1">MSKDTNFTYLHFSAARHADLFEDFCKNKLPDDEILVPPQHQPINPEDEDDVVPDQHAAFGIQRATQKIREPAWKDLGLEELMRKGPEDGRRKNKLGDSKVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9A3</accession>
    <name>A0A0B1P9A3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">EV44_g5841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001363">
        <property type="protein sequence ID" value="KHJ33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9A3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9A3"/>
    <dbReference type="HOGENOM" id="CLU_099537_2_2_1"/>
    <dbReference type="OMA" id="RGAFGNR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="126" mass="13875" checksum="495DA629A087EF34" modified="2015-03-04" version="1">MLPLGLLTAAQGFPMLVELKNGETLNGHLVSGDIWMNLTMKEVVQTSPDGDKFYRLAEVYVKGSNIKYLRVPDEIVDLVKEQQMRGQNNSGYKSGKGGSNRGDHRNNNDRGRGRGNARGRGRGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9F1</accession>
    <name>A0A0B1P9F1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001341">
        <property type="protein sequence ID" value="KHJ33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9F1"/>
    <dbReference type="SMR" id="A0A0B1P9F1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9F1"/>
    <dbReference type="HOGENOM" id="CLU_023208_4_0_1"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="132"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="57914" checksum="44F533448E12499F" modified="2015-03-04" version="1">MYLNDCCQQAKHYCLKVNSLGWFNKIEKRKISSGCFGEKRERVKPKNAFKPPCATLTATISSHSTSPRHFFMVSLLRYSSSQLRSIHNWNSSSHGPNLLTIAIETSCDDTSVAVLEKNASNSAILHFHSRITSDNRAYGGIHPLAAHESHQKTLAGLLNLALEQIPEPDHNASQSLNDTLKIGNKLIRKPHFITATRGPGMRASLTTGFDTAKGLAVGLQIPLLGVNHMQAHALTPRLVSAINASKNESNTTATGIKPEFPYLSLLVSGGHTLLALSRSIWDHTIIANTNDLALGDMLDKSARAILPTSYISQLSSVMYGRALEEFTFPESSDVHSYTPPKAFPIARNGSEHGYTWKITPPYISPGPEGRAKYFNQFSFSGIGSKAINIMVKCPNMLEDERRCLAKTVMTVAFEHLGSRVHAALNLEHLSNVKVLVVSGGVASNRFLRKVLRTFLDTRGFSHIELLIPSPELCTDNAAMIAWTGIEMFEAGFATDLSALALKQWSVDPKSDDGGILGVKGWIHGAMNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9M1</accession>
    <name>A0A0B1P9M1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9M1"/>
    <dbReference type="HOGENOM" id="CLU_1066307_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="261" mass="29438" checksum="9D80DCBD53A22336" modified="2015-03-04" version="1">MDEESVSMKDKLLPWRKPNEKFSLPPMPYQPIPLAFGHPLMTMPNHQNLSALPISRNELETVLENFLRTLKVEYDELRKEVGSVRQGMNRLPGPTSRQSNRVDNSTVDEERSVSSHVAKHPTLPPRPPTAETNTLVFPISSTRTQKPHSQTLLQTKQPKLYSQVVTVNPVKLWTVIGSSKAKSKKTQGSNSFPTPLKTPRSERERERRKGLPAHMQFLKLSYNIAGNLTGLVSENAMANMLLPNYGDLLLNTVLELDKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9M9</accession>
    <name>A0A0B1P9M9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000419">
        <property type="protein sequence ID" value="KHJ35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9M9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9M9"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="OMA" id="VWFLAFE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="303" mass="33514" checksum="AE24D3470D8E208B" modified="2015-03-04" version="1">MTEVVTVEPRGKISNQIKDIIAGASGGIAQVLIGQPFDIVKVRLQTTTQYKNAVEAVSRIYAQEGALAFYKGTLTPLIGIGACVSIQFGAFHEARRRLETYNTLNNKNNSNLSYTQYYIAGTFAGLVNSVISGPVEHVRIRMQTQPHGSRKMYSGPLDCIRKLLTTGGVTKGLYRGEMATLLREAQAYGTWFLVFEYLMNTDASRNGIDRKEIPSYKIAGYGGLAGEALWLSSYPFDVIKSKMQTDEFGEKMKYKTMRDCFRQTLKKEGVSGFWKGIGPTLLRAMPVSAGTFFVAEMTSRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Q9</accession>
    <name>A0A0B1P9Q9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="JNVN01001477">
        <property type="protein sequence ID" value="KHJ33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Q9"/>
    <dbReference type="HOGENOM" id="CLU_028946_1_0_1"/>
    <dbReference type="OMA" id="WCIYWIL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="113"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="514" mass="57322" checksum="F05BEE3BABA340F3" modified="2015-03-04" version="1">MKIAARKGKHRSRVLFRRQALTASKESLSITRRNICEKTSHIQSAKISSNSMATMSYESKLAIPDLFTSFPPLSDNLTTDTSWKQYQTVQECLPFLSAQEDGIEYNDYGIPTLDRERHIAFLHKSLKKLPAAFLTADASRPWILYWCLNGLATMGEDVSQYRDPLVATIRPIQNVTGGFGGGFAQISHLAPTYAIILALAIVGGPDSFDIIDRKAMWKWLGSLKQPDGGFQMSVDGEEDVRGAYCAVVIMSLLNLPIELPRDSPSWSHEKNSLLSGLPEWISQCQTFEGGISARPDAEAHGAYTFCALACLCMLGEPYKVIPQYLNIDLLISWLSARQYAPEGGFSGRTNKLVDGCYSHWVGGCWPLIQACLDGKFTSRPYFSREMGNSASDYSVGSLYSREGLIRYILCCCQDMSKRGGLRDKPSHRSDTYHTCYVLAGLSSAQNKWYFNNTPTCNVVNGLLNSAFYWSSEADNCDNHLFNEADRLISLHPIFVIPNDAVQKIHSHFISKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9X9</accession>
    <name>A0A0B1P9X9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001259">
        <property type="protein sequence ID" value="KHJ33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9X9"/>
    <dbReference type="STRING" id="52586.A0A0B1P9X9"/>
    <dbReference type="HOGENOM" id="CLU_070882_2_0_1"/>
    <dbReference type="OMA" id="KAKCFYF"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="120"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="22521" checksum="8D5DAACBD93C34B6" modified="2015-03-04" version="1">MADEPSIEFDQSDAYRQLDNYPWDQDSEFQGGLSAILGPHPVPSQIHDLTLRARCFYFSRKTSVPVSFNAYKSYLLALESQKDVFNSKEQCSLTTTSYQASLNIQAESSSRTLIPKKAAPYPPSFAEIISLIAKNSPIPGIRDIPSTVIPEQASVAVAPMRKKPWDPSLLQTKIDSDKNKSGGEDKISQISIEAVKQVELLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA38</accession>
    <name>A0A0B1PA38_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g3452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001376">
        <property type="protein sequence ID" value="KHJ33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA38"/>
    <dbReference type="STRING" id="52586.A0A0B1PA38"/>
    <dbReference type="HOGENOM" id="CLU_284568_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="412"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1091" mass="122897" checksum="D31DAB85F89F37B2" modified="2015-03-04" version="1">MLCWENLKQFNRPNSNEDVDELLPQFWGLIPEDDISVDDLVHQLSEIRSKIFLINNNSAPSDSSVKKRILSHFIKCCGGFYMSTVITLKDPTIPFLSAVTSLRESQAVYQDLHPPGLVNLIDSSPKSASNKENSVLIEAHAEVAEIQSSRKRRYVDFDDTISPEFSEDHHEFNLKGPIVTPKIKRGALKPIIVAKQRERDLKAAPQDILGPILYDREDVTMVNLVSLSMDNSGEMEVYSTETDTNDYALDPWYSDIYNYIKYGHYDKNMGRVNFRALLQKCTFYRIEEEIVFRVCSGERRRCVLHKEVSKVLTKAHDKGGYWSAEQTLKHLREYYWPRMASDVRNYVLDCLRCAKHGVQSRNITQSSARVIAPFVLLGMNFVRPLLDVDLETHEARACLWPHLLDIHAQFSCAYGPFHEGYPFVAGNRSQPPTKFRFSHVLAVIDYFSRFVWAFPCTGTSSSEVVRCLAWLFSHISAPVATYSDNQPFGSKVVKSFLGGLGVIPIPVPVGAHRSVGMVEKHNDLVERALKKEFGIWPLELQDAVKALNSRFPNLHHFPSSPPASTPPPLIRKSLNEAVVNRPIKEPVPPSKRAAQNEADPIQTDQSDEIDTHAYLPKELAEIFMARQQQESAWQIRLLVCTSFFSCMENTVASFKEGEEKEMAKTIHAHLRTAISQFAISETCAPPLEFPQHTKGVKINAILKMNLPKKPTVAATHRINATLKTANALPKVPKTTPMLWTTVVRNGQKKTRLNEVPDVTIDTNLQPQKSAAKTTFNIAQNQNQSQKNKKQLKSIDDMKLFFRLSNEHEWRKLSPAGIREVVVKKLSILPTSIGLIKSVRTGFALSPRNNEAREALLKLSLRLSSFGAKLEPATSWLPVIIPTVPRYIRTEKGQVEVTKELLSDEIEIVTSMRPNSIKLYGHSHLEAPDRTWLALFTKAPRPGFRVFDESGMMRLFKKQPLSDFCKRCNGHHSPKNCSRAPSCGNCGSTMHNEDLCMAPTKCRNCGGPHRSDSCKCLARPTRNGAPTKEQLKIIRQAGDREFQAVLRAKAAEERASVLEGNSDEEPSQPEVVDMENTQALSVEDTAGDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA50</accession>
    <name>A0A0B1PA50_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative actin cytoskeleton organization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000509">
        <property type="protein sequence ID" value="KHJ35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA50"/>
    <dbReference type="STRING" id="52586.A0A0B1PA50"/>
    <dbReference type="HOGENOM" id="CLU_016305_0_0_1"/>
    <dbReference type="OMA" id="VCNLMTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="72"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="688" mass="75549" checksum="9778FD03774948C9" modified="2015-03-04" version="1">MSVVELGTDLSNEKSIEDWLASLNDQLQEKGLKDEEKCQLMISLTKILNDDNRQVNKPQSNSKLYHQLIDDQCLETIIENLDLRQSQLTRSHVILAISAYLNAADNSGSEKISRLLLSKIKKGTSEDFKVAFSAVASLFPVIPDHVSTIVLNEGFLSSLELLIKRKEKDGAIEQAVLEMLNVACMNTNCRDAIRKICIEWLTEKVQSNSGPSSINKYSESIKDLAAIILAKLQAVPPLPTLGTEERIQPASITTEELSLRFKNTFLQGSSEQSSIEGLAYTSLNSKIKETLAYDQIFLLAIIKALGEAPAKSSTIFGALTILVNITAYKPVLLEEQKRINQLKAYATATNLSKTPDNLDQLDDDEHVSKRCQAVFEAGIIPILVTHIQNSSTSSLTLAVSVTSSLARTPKIRGKMAQQGAVKMLIHAFSKFPTENQSGRRTAALALARILITTNPNHVFGGSNPISITSAVTPLVLILSDDPTVEHRDLLPVFESLLALTNIASTDDTARNSIIRLTFSQLEELLLSNNVMVTRAAVELVCNLVQSPEGVAKFADGSKQASNRMHILLALSDAEDSATCKAAGGALASLTQWDTAVNSILERDRGARLLLRLCKEDEEDLRHRGVVCILNVLSIPNEIGKWGYEKIKNEKGFEILKECLKKSKNQEVLDIAVEALKLMRANEKHESNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC7</accession>
    <name>A0A0B1PAC7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000487">
        <property type="protein sequence ID" value="KHJ35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC7"/>
    <dbReference type="STRING" id="52586.A0A0B1PAC7"/>
    <dbReference type="HOGENOM" id="CLU_018398_0_0_1"/>
    <dbReference type="OMA" id="ECGDKGQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="491" mass="56357" checksum="6D2587C9040C5FAA" modified="2015-03-04" version="1">MPRIDQSLIRKAFKISPYLPVILQATRCLPSAINELRWLKNHVQNIKPALCEAKAKLKLYTLVKRRACGEPLQYILGSQPFGDLDIKCKRGVLIPRPETEAYTIHLANLIKSNQLHPSITETFSQKKFTPKEGGRQYPPRIRILDACSGTGAITLLLCSALLKKETYSSDILILGIDISPKAVNLARENLCWNKNLGHLPNFAGRNIRFEQRDIFEDYHRGWDIIVSNPPYISHSAYDHEINRSVRNFEPKIALVPPVPKISFRAGGHPEDIFFERLIHMHEKSVSKVLLMEISDVAQAIRVVNIIDKYERVRMQNRVEFWRDFPDGKSDNRNLKMVNVGSMIVKIKGVGKVRSVILIRKDSAIPKSGKDYKIKHVQLTNIIRTKPQEPKRQLYGPPELKGTWKYLNSPASTDGRATLAMGRGWGSQRKSLVRIKANKLFQDKLKFENQIQVRNAIEELERPIKSKRATQKRGNFSLHTEPFLMRHFRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAD1</accession>
    <name>A0A0B1PAD1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nima interactive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000969">
        <property type="protein sequence ID" value="KHJ34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAD1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAD1"/>
    <dbReference type="HOGENOM" id="CLU_010128_0_1_1"/>
    <dbReference type="OMA" id="VKMETRW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="757" mass="85847" checksum="BB862CC96AFF8C68" modified="2015-03-04" version="1">MNGMDSANLNTASQYLNNQLLSRGFLRHGQNINFAQRGNEHCSQIQIIRLVHDLILHHDRDATQRESMVDTVRALRADSAKLSVEVERYKDRENDVRRKMAAIEAEKTTFESRLGISEANERRLKLEVEKLKATVGQVRTMCAIDCRKRDKIMDGLKKTISDSGHIRGGKRTKVREIVVVGGIGREQKKASSINVDTEGYDLRSETNEFLTELAKSLSEDNENLSHLLWQTLDTLKNLSGWSSENQTNTPIIGTELEKLSMELKGVIEHVKILLTNPNYVPLEEVEIREEEILRLREGWEHMEQRWKDTVSLIDSWRKRMMCSGETVNIEELKMGLQLDALMPPKDESLDFNLSVVREESEEEYDHSDLSNTNDKTCALGSNSQIESDMDKSDFSSSSFDDVCDEFSHVKEDRDLVHNRFGDHEARCDTSSMSPYSVPKLSPLHEITTNTHTSTKYSPTKPRRNFSPSFEDDTIDLLQLDFSPIKAKDDSRELEYWPLKIINSVDGLNETCNSNDSDQNEILDKNSTNRSETSTLSQSSVFNDKNSTSVSISTPQTHLKCVLSPPKYTSNTGSHNTPTKSVSIPRLKLGPDCRLPRPRDMALRQSPLAMTRINGKLAASAREADAARVRAKLKAVRYKNSAVTAGNNSKLQERECRSSSTVEAAMNSTISPEIVDTSKNFNTEESCRTNNNGRQDSEIIDKENSDSSPHSDQGRIRKRKAKETCHKDVSKNRRRRRKSTLTSWELEKLIVGDTDPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY8</accession>
    <name>A0A0B1PAY8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g2058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001032">
        <property type="protein sequence ID" value="KHJ34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY8"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY8"/>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="366" mass="41178" checksum="00531A0495B7ECEC" modified="2015-03-04" version="1">MSDFTLRETPLRTVQVDALVVMKIIKACSSAFPSVSTGSLVGMDKNGVLEVTNCFPFPVIDSTLSDPHSNEHQVATNLAAAAPRSKGNISYQNEMIRCLREVNVDANNVGWYTSANMGGFLNSNLIENQFLYQKDPNERTVALVHDVSRSSQGALCLQAFRLTPSFMAIYKEGKFSTEFLQKSKFTYKEILIEIPVVVHNSHLLTTFLLQLPTSIQEHYEIPSSLPELIAHQPPTPFHPNIDSLELSIDPYLEKSCDQVLDSVETHYTELNNFQYYQRQLAREQAKVAAWKTKRTAENASRALQKLAPLPEDEWERIFKIPTEPSRLESMLNARQIDQYSKQVDGFTAAITSKMFAVKSSLLPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB79</accession>
    <name>A0A0B1PB79_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hydroxyisocaproate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000196">
        <property type="protein sequence ID" value="KHJ35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB79"/>
    <dbReference type="STRING" id="52586.A0A0B1PB79"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OMA" id="HMGTETC"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="57"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="332" mass="36338" checksum="BE017885085E941A" modified="2015-03-04" version="1">MSVPVILRVGNINQTQKEWNELSKFGPLQVFEGNTRQELINSFVNGEFDGIVAIHLSYDAKVWTGTFDEEIVSSLPESVKFICNNGAGYDNIDVAACSARGIRVSNTPMAVNQATADMTIFLLIGALRRIHLPYLAVRAGQWRGGSAFRPGHDPDNKILGILGMGGIGRDVALRAKAFGLKVQYYNRSQLSPELEQGSKYVSFDQLIQTSDILSLNCGLTKETEGIIGKKEFNLMKDGVVIVNTARGKVIDESALVEALESGKVFSAGLDVFENEPQIHKGLLNNPNVLLMPHIAASTIETERKMELLVLRNIENALSTGSLLTPVSEHRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBF7</accession>
    <name>A0A0B1PBF7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HbrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000975">
        <property type="protein sequence ID" value="KHJ34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBF7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBF7"/>
    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="OMA" id="VELWLFT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="830" mass="91360" checksum="3321EDEFD137DE7D" modified="2015-03-04" version="1">MTTNNSSKRAPGSFSAAVVTIPTTRSDISKAGSFSSSTEDLQSSRPQKPRLNTNVSRNNNYSAQGLVQPPRPLYASSQGNLSASSLQSFNFSRPTTHSNNVRAAETPPPRLTRQNNSQKMSNSEYHRHGRKHSSTQGSFEAYLPTAANNSLGNMTSLNTGLSASHITAQAVMQHQTHMRKRSQTVPSPQSENNSKQFPARGPSNAQVQAFLDSPAPYENGLGTQNYHNSLMRGAQGIVAHAAASIVFPNSTVTSPGLPPEYSTERENERENENEKEKPIRSEKSKVKLFSRPVKIGISKDKDTKAGLIPSPNMNNGIQNQRVNYNTGSITDSQSSSLSIYTLGNTSSATIRPVEAEEKKSEKEKHKHHFLSRQKHKLTNKEDHNLPLSSAASNSKPVDPSAPSSLYNFNTPLNTSVSSSSSSRSMSGLDLRHGARVLRDKKKDKDEKTEGTIKEGEISYQNLSSDKTGNYLTSYGATSFLAASSASYASSICGYDTPTEIAKNGLDRMGPDDAWPFLKTKLLSVFEGDDLRLPVEDLNQVVLLHIQASHRKRTQTKNLNDDLLDLLRNGFILLNQSLRFTPDKYFIPQLVEMWIFTFTVILPFMQAVFLPLDLEISKNTSKNQNSNGNQGDLNVRSMVLRSYRDIVILPRFEKLKDLFSRLHSEYPLTHLPDQSMLSPFSESSIGRPGTAMSLDPGIASYSSQTALLSDSFSPLNRGRTFSSVSNHAPNESPVTSGFGSFHLHDRSNEGSERLMARIIGRLLQCVGVLNSVHNGADNEAEGESIKEKMDELVRGLKLDLIERERIGRDKKNFVGARVRVPVLSFGAAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBK4</accession>
    <name>A0A0B1PBK4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative trna (Cytosine-5-)-methyltransferase ncl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g2710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000960">
        <property type="protein sequence ID" value="KHJ34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBK4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBK4"/>
    <dbReference type="HOGENOM" id="CLU_005316_4_2_1"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002127">
        <property type="term" value="P:tRNA wobble base cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="846" mass="95928" checksum="4426858DB940EEE2" modified="2015-03-04" version="1">MGRGGKRGKFRVRNCTDKCQLEDNRVSFDKVPKSNERFEKYYNQILGLSDDEKSVFWEALKRELPNSFRFTGSKSHALAVQKLLKDRYIPQISAISHHDGTLVKPPEPVNWYPDELAWWMTTPKSVVRRSPPFAAFQKFLVSETSVGNISRQEVVSMIPPLLMDLKPGMTVLDMCAAPGSKAAQLLEMIHAGEEFRMRKSINDYAQNKGQEIRTDSVHNTKVDLNIDNEDFGRATGLLIANDSDYKRSHMLIHQLKRLSSPNLIVTNHDATMYPSIKLASSSKNSSANTYLKFDRILADVPCSGDGTIRKNVNLWKDWNPGSAIGLHMTQVRILVRALQMLKVGGRVVYSTCSMNPIENEAVVSTAILRSGGLSKVRLLSCDDDLPLLKRKQGLRNWCVMDKAGKIWSSWNEVLVSKEKNESSPWIDKLLPGMFPSIDSPESQIPLQNCVRVYAHLQDTGGFFIAVLEKLSEFRTKPESKITPMTSSSNHSSNISSNVQLDEVDQTAVSESLISNMNPANIKTEEKVDRINHKRSIDELDTRKEILNSEKKQKLTEIVNDVEVHETSIDIIAHENMYEDHEKITLQTHPNRNKYGTVEEPFKYISDDHAEIQAIESFYKLSSRFPRDRFMVRNVLGHPTKTIYYTSSLVRNILTENEGHGIKFIHGGVKMFMKQDVQGPNVCKWRIQAEGMPILEGYVGEERVIYLSKKETLRKLLIEMFPKIADEAWKDLGEIGEQVRNIGMGCLVLRTNPSSEEDGIQERMVLPLWRSAASLNLMLAKEDRTALLLRIFNDNTPLINYSKEARTAAIKHASAGDSKEQIEINELKRSSELDEKKPDLVPLEQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBT7</accession>
    <name>A0A0B1PBT7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative wd repeat-containing protein 79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBT7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBT7"/>
    <dbReference type="HOGENOM" id="CLU_022731_0_1_1"/>
    <dbReference type="OMA" id="IRTWILP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="428" mass="46674" checksum="621FFBD9519A4CB0" modified="2015-03-04" version="1">MEQPLKNPELIASTLETYRCSITESKKREDILLESSSSQPTGLEKRQENQDESNYFKTALWLLTTNESPDGTSVLTSNADNTIRTFIIPPNLLSSEELIRLTPYTRHKNPAPVNCLLAFPLFDLSSPSTTLYLSTPNGFPIRMLNALSPSPVIVSSYNLISETTESYITPASKAFLSFSQFFTGSDSLIALFDLSNNGSAPILRLPTIPSKRHRMKGGGVGMRGIVSSMAIQTGQNETLAAGTWTRWVGLYDAAGLGGTIANWSVAKAADEVASIGGSGISQVIWSQCGRYLCVAERMSNGLMIFDVRVTGRLLAWLKGRKASTNQRLAVDLFQTKSGIEVWAGGTDGVVRVWENIGSKSGALERDWEWQAHEDPVTSTAVHSSGTVVATCSGQKSLSAFESSDNDSDSSSPYQKKDLYDNCLKIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC35</accession>
    <name>A0A0B1PC35_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000987">
        <property type="protein sequence ID" value="KHJ34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC35"/>
    <dbReference type="STRING" id="52586.A0A0B1PC35"/>
    <dbReference type="HOGENOM" id="CLU_002055_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46526" checksum="A1FB8F42A0928BBA" modified="2015-03-04" version="1">MLRSSSRIRRLAEKAKDSQEQASRFHSTRAQLCINFVNNCEDIFASSRQKELRGLLDMNVFEQVPLSSVPQGTRIFDSHFVDEMKMPGTAQVYPKSRLVVQAFKDDGKLQVPTQSPTLDKDTLLKVVKFLYGVPEADMQADDTLTSATDRFAAIEQKAITNASNILKPVQKLTIDNPLMFNGAVLKRKIDHYTNGLSLKKQYVAHRAWGAYIASVCQPEANFDYSIAAQMNNDVFLHKIQIDRINMLNKWIKWQLDSPNRDLTLKSANLDSVKLVHTNAFHANNRDMSSQIGYAIVIVDNNNTVNLLHWSSFKYKRIILFFLASELYAMVHGFDMGIAIKTTICAILGRQIPMYLYTDSHSLYECISKLGTTQKKKLMIDILCLRESYERKEITELRWIATQIQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC76</accession>
    <name>A0A0B1PC76_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000236">
        <property type="protein sequence ID" value="KHJ35833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC76"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="230" mass="24979" checksum="72170E9EE580518B" modified="2015-03-04" version="1">MTDSMEISQESLAPTTDLSHQPSPIPPVPPIPNPPPSIASTSPPSQTTSNNMSTDRQILKPVAPSKRPIQHRPHHNSRNNSDIANAFLPQELADIIATRQCRERAWHARLMICTTVISSIDSTLATFTKEVEIEEAVAFKAYLKLAIANFAAVDSSPPPPRVPLHTRPNKGNGNDSSKGKSKEKNLSKIAAAIPRIACNQIPNLGSIKEVELPKIIKNNDTSWATVARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCH7</accession>
    <name>A0A0B1PCH7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fibroin-3 related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000184">
        <property type="protein sequence ID" value="KHJ35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCH7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCH7"/>
    <dbReference type="HOGENOM" id="CLU_641230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="428" mass="46653" checksum="9359FF0956E81CAB" modified="2015-03-04" version="1">MPYLFNEDHGGVNNGKMNFLEISLLRPRLVSDQLSDQLTNQVSNVTSSFTNWDKCMIQIYCKWPAIIGLVIGGLIVLSIIICMTRCLCFGYSFCCSCFSFLSCCGCCRSCCSGKRRKSIAYKNHSSSDYRNQGYSAPPPMMKGGINNSQSARFSIYKAKSRPVNEDSLPAMPSWDTATSVHVLDEAEDSESVELEQMNSSIGQKTPLVTAAAVTGTSSPLGQENVLAPFKTRQSPNNNNSYINPNTSNLNRSNENLIDQYSSNPSIENGARFGGSSSSLNGIGYGIPGQRPYNEGIRSTPMRAPYQESGRSSPMQAAYQESGRSSPMQAPYPGNGRSSPMLAPYPGNGRSSPMQAPYPGNGRLTPTQAPYPDNGRSSPMQAPYQENGRSANPYNQNRFGSPIPGGRPQMNKYNPPLQGQRPPMGYQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCK4</accession>
    <name>A0A0B1PCK4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pex19-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000031">
        <property type="protein sequence ID" value="KHJ36412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCK4"/>
    <dbReference type="STRING" id="52586.A0A0B1PCK4"/>
    <dbReference type="HOGENOM" id="CLU_043063_1_1_1"/>
    <dbReference type="OMA" id="YEPMKEM"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="335" mass="37196" checksum="E023F6E9CB76FF0E" modified="2015-03-04" version="1">MEKRSCLEDKAEASTDEIKNDQKLKSNNENEPGNEVPQKKSEPSAELKYPSNDDSCDDLDDLDDMLDEFGPVVPENIVASNTEPQKETITDDDLERQLQAGMAKLFGDIENPIELSAKFENILKELGEATAQGKTCEAQPSTSTESKEPKTGKTESSIKTETETSFQDTIKKTMERMELSGEQATAAAAALENNGDILSEMLKAIQGLDMDGEAGGEEDFSKALLGMMEQLTNKEILYEPMKELNENYPGWLEKHAKEVNSADLERYKKQQVYVSEIVKRFESEKYDDNSVADKEYIVERMQKMQTAGSPPSDLVGDMAAAQEIFGAPEEGCPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCP9</accession>
    <name>A0A0B1PCP9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-succinylbenzoate-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCP9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCP9"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OMA" id="KGKWFKT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="512"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="612" mass="68878" checksum="867795814D79336A" modified="2015-03-04" version="1">MKGMITCFKWNDTFKTPCKYKFLRIPSYRRFKTAHNSNHLLLKMNSLPRIPIFDAMYSHDPNSTAIIHSRSGRRFTYGELLKDISEEKFKLLQLLKKERNEENPKYGHRIAFMVENGYDYIVSLLSIIGAHSLALPLCSTFPVSEIQYILDHSQTTILLASSKFHTKAKQVIDVCHKCHLIEINKKKGGSARENINFEKPLDVEGGLILYTSGTTNRPKGVLLPQSVITAQSKSLITAWKQNSKDHLLHVLPLHHIHGVVNGIIAPLLAGSKIEFLFPFDATATWERMAAPYLSNSKTSEKITYITAVPTIYNRLLTTHQQLPADVQIASRQAISPLNLRLNISGSAALPTSIKRSWKDLSYGNILLERYGMTEVGMALSCGLANEDRVDGSVGWPLPNVQVRLVDTETNKVICQGEELDEFGRERDGEIQIRGPTLFKEYFQNSSATISEFVESDDEFGRWFKTGDIAIRRIVETAGHSEQEWARGPMYFIRGRKSTDIIKSGGEKVSALEVERELLLLPQISEAVVVAVPSGAWGQKIAAVVILTQEFIKTNGKLTPLDMRKELRSRLANYKIPRLLKIVDQIPRNSMGKINKKLLVSELFNDDASGDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCS7</accession>
    <name>A0A0B1PCS7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative signal transduction protein syg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000859">
        <property type="protein sequence ID" value="KHJ34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCS7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCS7"/>
    <dbReference type="HOGENOM" id="CLU_006116_1_0_1"/>
    <dbReference type="OMA" id="GDMYCSL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="697"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="940"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1008" mass="116733" checksum="434892A38F5D2F9A" modified="2015-03-04" version="1">MSFGHNLDRDLIPEWRIKYVDYKEGKRHIKAISRAFNRVATSARNNVGASPLPTRENSRIGPLSSLSQRRIHHPMFQSFDMHQGARGQSTRDESSPKHWILSPFSANHSKLSVTSPSADKSGKTPELSMDNIINHAPTKLITEDLVNKDRQQNDPISRDFANMHRKPSIFSHSIVESTHITSPTGEPNDYFNSRYRMPDSPKSFLSNVFSGGGRLSPAESHQTNLDIGATDVLRQRQNKFFKWINEELEKVEGFYKLKEDEADNLLTLLREQLYEMRTRRVEELAEVEQLRALRRETEATLDFNARSEALEKSQLSSSWNRFNGIFSPIQKSYVKLRHKFTSSHIGSNSKALQNMKPSVASRLQRSTTMFRGTGDDKTSIRKAQYDDNVPYRKAKRKLKLALLECYRGMEMLKSFSVINQMAFKKINRKYAKVVGSSPHVRHLSERINRSWFIRSNVLDAHIHEAIDLYARYFENGQHKIAYGKLRGSFAPRADVSGNTFRSGILIGIGAVFAIQGTIHGVKIMNENPDPVIRAHTSYLFQLYAGYFLALYLFAFFCLDCCIWTRYRINYQFVFEFDPRRTLDWREMANIPSYLLAFLGICMWINFSKIGGQQLFIYYPMILITITAVLIAMPLPILFHRGRMWFLYSNWRLLLAGLYPVEFRDFFLGDMYCSLTYVMANIEVFFCLYIHHWIDPTQCGSTHSVLLGFFTALPAVWRALQCLRRYYDTRDMFPHLVNCGKYIATILFYTTLSRYRINRTNLYMIIFLVTAALTSVYVSLWDVLMDWSLLQPNAKVRFLRDVRGYRNTWWYYTAMILNPTLRFDWILYLTNIHLLGHSTKVAFVVAFAEVTRRGIWVIFRVENEHCSNVVHFKASRAPQLPYTAAVETKEAVVEKEDLVKGKSIHDPTIHTLESQRSLTSNMRRPLTRILADAHLKDFEKKRIRPDGKDGGNSISDGHYQSDSSDDEEDNDLNNQVVFDVAALLKERRRIARETTHEEVVSPSFVKPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCU3</accession>
    <name>A0A0B1PCU3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01000150">
        <property type="protein sequence ID" value="KHJ36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCU3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCU3"/>
    <dbReference type="HOGENOM" id="CLU_272763_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="681"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133062" checksum="B9858F148E61CA91" modified="2015-03-04" version="1">MTEVNREVRSHYLFEIATEVANRVGGIYSVLKSKAPVTTAEYGDRYTLIGPLNRQSAVVEVEALIPTNPVLAETIAAMESRGITILYGRWLIEGAPRVLLIDTKSGYRFIDEWKADLWNTVSIPCPSGDEETNEAVVFGYLVAWFLGEFVAHEKKTAVIAHFHEWLASAALPLCRKRRIDVTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERAAAHSCDVFTTVSHITAYESEHLLKRKPDGVLPNGLNVTKFSAVHEFQNLHQQSKEKIHDFIRGHFYGHNDFDAENTLYIFTAGRYEYRNKGCDMFIESLARLNHRLKASGSKMTIVAFIIMPAQTQSLTVEALKGQAVIKSLRDTVDVIERGVGKRIFERALKWHDGEAMPDDKDLITSQDRILLRRRLFAMKRNGLPPIVTHNMTNDSEDPILNQIRRVQLFNHPSDRVKIVFHPEFLNSSNTVLPMEYEDFVRGSHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSTDYGIYIVDRRMKGVDESVNQLTSFMFDFAGKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPASFSDGKVDFIPGIEQKVSRPFSVPGSPRDRSGMMTPGDFASLQEGHEGLSTEDYVAWKLPEEEDPDEYPFPLTLRPKKESESGSPAPIASTNGGGSTQIREPVPPSKRTLTEISHNDIGEEMSNVSKFIPQELAEIVAIRQRRERAWHARILICTSVISNIDSTLADFKDEISREEATAFQVYLRQAISKFAAHDSLPTPTPPPIPSKSFQKKQSEILNPKLPNKPIVVATPIMIPTSTAIHDPTHLKKANHVERLNEPRASSDLPRRQALESKSTPPGNADKRIFLRLPQEHEWRNLSPAGIHEIVVKKLAISPATIGRIKPVNTGFALSPCSNDAQEKILEAQHGLFMSGAKLEPATNWVSVIVPTVPTYIRTLQGKIEVNKIMLADEIERVSSVRPFLKLYGHNNPAAPHRTWMALFAKAPKPGFRVFDESGLVMIHKKKKPLEFCKRCNGHHPSKNCSRAPSCENCGSTMHTEDICMEATKCKNCGGPHRSDSRRCLARPTRSGIPTKEQLKSYRQAGEREFLAVARVKEAELKAAIAEESILDLDSSKKTNSNSSETQASTVEDSTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDA0</accession>
    <name>A0A0B1PDA0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000448">
        <property type="protein sequence ID" value="KHJ35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PDA0"/>
    <dbReference type="HOGENOM" id="CLU_000211_1_0_1"/>
    <dbReference type="OMA" id="CIIPMVA"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="9">
        <location>
            <begin position="11"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1974"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="2314"/>
            <end position="2346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="3142" mass="359240" checksum="5D9BFF50334353BF" modified="2015-03-04" version="1">MSMSSDVEALSNHVALPAKLPGCQDSNLNEIEIQLIRRLLTASDSFLNIGNSQDKEVLSSLHRSLSLTLFVHANGGLSRSDIISALQGLNDHEFVLFHITEQNAGITVTLQNRFVPTNTAELLVFGTNFSKSMDGENLLFEIMEASPKCQDVLASSNALIWKFPSFAVTIPKLTYNEFDLKDELANFLVRASGESVKHVAAHTNKSQALAYESRDSVDPVIISGILVTILKSGGTESYPTPLIKRIRDDVCWDGTGINPWRRSPMWLLLRVAIERYLCAELNWEIGQIYYKVLMCLFHSQFLLECTKSSQIRGDLLQHLIKKLVIRIDKLHAKESTIKTEFLSQFIELYNALEKNVHVVVECAEKRLSDITSVPCNPDIRGIPFRAEDKFCKLQLLNSNSYIKKVLDISRHKIPSLAFQRGSSVNIQISKFQPNMSTLENLIELAKLESDTKNLLQQHQSGNQSHESYDSRIHTIADLIKVYVETVGNSYDDNPEQKSRMLLLVLELWVELDKCAVQSFNLLKKYSPGISQEITNVLLLSCCEDLERLHRVQTYLINRHNECSNSSITLFIQPHKDCFAVQYYDNLSKNSIMKQSLNQIEADAQRMRAIKKNEWQELSKEFQSLEDEELSLSHETINGEHDRRRCTNFPKFTLASAAKPFTNTHFARVKFPVRESDICLPNGAKFQYYDSINNIWPDKLRKVSYAHHCRLVFPKNSPYSSFSESLGLKSDVPGPSSYSIVASDPKCPDRTRIQEFLSMQTLLSGYEHRWIQILIELGSSNINFSTESATFLMNHLILQVGPRDDNDIRGIIHRIFLDQSFCDRLIFWIKGRLEEISSSVRKREVFLMEILVNLAVRLFELGGQGNKEEGIKILTNAREITLSWLSELKNDIKIASSTEITQKLAYYIIWAALLCRRTFIVFLGSSSISHSLFTSYLESSICLQENLNDSDSNLPLSLEAALHRDTKMVWNLRHTLRSSLNMKVLVSVILAHMPSLALPIFSDTTSIEFHEAPRDWWLQIITEESENFKQQNINLHLLTGHLLVDGKPIGKLSKEWRESRIYKRIFGTEEIQIWPSHLLGMDYVLNQKRHNYEVHFGTRGGENIIQAISQYDHLELLPSEIFLKNQISDLPSFLVSSCAHWLNFKKKRVEIRQISDPWKLRPTDWTIDLKICIATSFISNKKLFLVDPYSRPFKIVTKIFQGFEKPSEILMMQGEKGSIRVVFPRLELKFHVNENRYFECPQLGAEIDPNQDIRTWYGLKNKLVLRCVVRGPASQKSMSGVGKSHKLNRRIVLVPLGKINYKKSGINTEVSVTNNGSYARFIVNEILGRIETVDLGDQYLKAFYHAVTSRLIPDPLTGRTGTEEAIHCLNLANCQPAVPLLETQKSVLRELANLTPCRNFYPRHMKMMQETSWNKNLTTTIQYDGYRAIIEKILEKSQHLSKFFDGASGHEQISTYSADILNKRNIIRRDLYTRRQSWEEVSLVSRDNVYSGHDIKPYVSRLANVQKCILLIQNWSQFLPTTKSLGKILEGWSSFQGFSQSTTEFSISDLMDMDIRSHWGSLVNTMRSIEKSSKYKLMFLLGIISFHKNVNMNIITSLIAFAISNELKVLEPPNCLFYHNYKNNELPTVQILLNLLRNAYEFEKGSEQELQALKIAENALKQWPCAEPDIIQCSKFPSFNAKKVKKLIYPEWLRIFQNYELSNYISQVQIILNKLHCVLHKNEDQIDYNFGSIDSKFEILERDSKISAVPVLIGDLLSSDIFCQEPESTKFHSNSNIGTSTDQKPLFTWSSLDFDKSNVSSCYSHLHLEDSSQEVFTLRKIVDNLSASNSIIDQKYAVDLSESLDAFQNKSIFTKMLKLPKIIPQNCLDKLLQAIEDADEIVSRKLKYFQDCCDKIMPARSKWLKQAGLWPCITPISLLETLRSTLSFKFGLSVKEYIINYAISITNLQRLHRIRDAITKLDNNRASEELKNLGHENWNPMIHPDWLLLEIDGNFLIRPGQIDVARETIFPTNGKNSVLQMNMGQGKTSCIMPMVAASLADGVNLVRVIVPKPLLTQTILLLQTRLGGLVGRIVKHVPFNRKLSKYQNIAENYLDQLQQIQKVSGIIVTLPEHILSFKLSVNQALSDGRINQSRFMSEAQNWILEKSRDIIDECDEILSIRTQLIYPSGTQKTIDGHPYRWEIVETLLQLVKSHINSLEIKYPQSITISRLVDGGFPLFSFVKAEAEESLISKIVDDICSGRSQIIPKYSSNDQLDIKNFISNVTVSDEVLNKIDLLDIENPINRQALYLLRGLIAHGILTLTLKKRWNVQYGLHPLRDPIAVPYYAKGCPSDQSEWGHPDVAIILTCLAFYFEGISSSQLCQTLKQISQVSDPIQAYNSLIQGNSSLPDSFEDWNNINLEDDLQLNELWRYLGRSIHVINFFLNKFVFPRYAKQFEHKIQATGWDIPACVFSSNTQGTRTVTSLTTGFSGTNDWKRLLPLTISQQDLPSLLHTNAEVLIYLLQKRNLGYYYAANSSGGRISELELLKAITDCKISVFLDAGALIMEMDNQSLVRAWLEIDLTALAAFYFDKDNKPQILYRNGSRVPFHSSTFSDNLENCLVYLDQIHTRGTDLKLPPTACGALTLGPNQTKDVTVQAAMRLRQLGTTQSVKFFAPPEVHQSILNLQGKDSTAILSSVDVVSWLLKQSCHGIEQLLPLYFMQGYDFCNRLQAALTYPNIYDSTSRDRQDFLSVIQPIEDCTLVELYGLKKKYKGISQQISDPDIISLLEKLKEQCKDFIDTGNRYYSASLNEAEHEVEQEREVAYEVEIVQQLQIPTIYYPLTFPGLHKDILNFVMTGKTVTNTNGYESAFDFIGRTSIGKNYKIEKLFTSQKLFVSTEFGRTVNKTKLEQIDHLHRPVHWILWSNISKEAIVIIPEEAEIIIPKLRKDSHPVHLLTYASPVTRKMLIFNDFMHYNLPPLSPTWCAPLWLRIEVGILSGRFYFDFLEYIALLEFLGVREVEGKLSDDKVDAIMHPSDSLFNTLKIKNAQQSFASKPLHFLQEWLALRGRGIDFSHTPMGFICKGRPAQAHHPFFKRLQHNPIYKNPISYKPENSSRENYQMSTKITDQEEYDFLFDFENANDDLNDESSAVDIENLINFSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDK5</accession>
    <name>A0A0B1PDK5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative upf0480 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000395">
        <property type="protein sequence ID" value="KHJ35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDK5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDK5"/>
    <dbReference type="HOGENOM" id="CLU_073620_0_0_1"/>
    <dbReference type="OMA" id="FTFGMPK"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059573" evidence="7">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="228" mass="25328" checksum="AEB634C2EC320E4D" modified="2015-03-04" version="1">MHLRCILLLSINLLTIFAAHLQVFIPSVSITNSASKLPPSTHATLTTLSQIYSAPLQEKGNFNFPNVTTGSYLFEINCHAFFFAPLRVDVKEAKDDLHGQQEVVEVWGTFRGNEWDNKGETVIVQTKDEGRNKLFIFEAQMLAAKNYLTERAHFSPLNMLKNPMILMAGLTLIIVFGMPYIMDNIDPELKAEFEERQKPSAPSLGAPNPLQNFDAAAWLAGSTGGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEB0</accession>
    <name>A0A0B1PEB0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Catalase</fullName>
            <ecNumber evidence="3 10">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10"/>
    <dbReference type="EMBL" id="JNVN01000601">
        <property type="protein sequence ID" value="KHJ34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEB0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEB0"/>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_1"/>
    <dbReference type="OMA" id="YGDWSNI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="37"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="698" mass="76702" checksum="B50611A74C089663" modified="2015-03-04" version="1">MNGASNQNPSSSRLKVREVDSDILHQYKVDDSNSYLTTDAGGPIQDNASLKAGERGPTLLEDFILRQKIQHFDHERVPERAVHARGAGAHGVFISYQDWSNITAASFLNTAGKETPVFVRFSTVAGSRGSADTVRDVHGFATRFYTDEGNFDIVGNNIPVFFIQDAILFPDLIHAVKPEPQSEIPQASSAHDTAWDFFSQQPSTLHTLFWAMAGNGIPRSYRHMDGFGVNTMRLVTNDGTSKLVKWHWKTMQGKASLVHEEAQVLAGKNSDFHRQDLWDAIEDGNGPEWELGVQIVDENDVQAYGFDLLDATKFLPEELVPITLLGKMKLNANPTNYFAETEQIMFQPGHVVRGVDFSDDPLLQGRIYSYLDTQLNRHGGPNFEQIPINRPLTKVHNNNRDGAAQMLIHTNRASYSPNTISSGNPKQANQTAGSGFFTAPFRTVSGSLYRGIASSFADVWSQPRLFYNSLIPAEQQFLINAIRLEVSQIKSDIIKQNVLVQLNRVSNDVATRVAAVIGLPALTPSPEFYTNASTKYVSIFGNPLPSVTGFTVGILTSVASSSSIIQASQLANSFTSYGLKTLIIGESLQSGINRTYASMDASLLDAVVVTDCVEKLFNSGIKASTLYPLGRPSQILVDAYRWGKPIGSVSSDRKIFESVVPGVTGDGVYIVKTTDELVSEVVNGLKTYRFVDRFAIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEF9</accession>
    <name>A0A0B1PEF9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000293">
        <property type="protein sequence ID" value="KHJ35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEF9"/>
    <dbReference type="STRING" id="52586.A0A0B1PEF9"/>
    <dbReference type="HOGENOM" id="CLU_066684_0_1_1"/>
    <dbReference type="OMA" id="MHFQPVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="10">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="225" mass="25620" checksum="296FBFCD89F6B1DD" modified="2015-03-04" version="1">MEMNMNMNMNTSLLGDKVGDTQTNCVTWSNDELQDVFGSHSPFNGESEGFDNRECLDLQRLKSKHETEGYREGICQGKEKSVQMAFDEGFGLGAALGSHVGLLLGLLEGLSRTRGLDVGEVERLQELFGVAEKELSVRNIFGTEWWEEQELWKYDITDIEDESEATFHHVAKAHPLLKKWATLMEEEIRKWHLNLRIYEKAMPATTIKGVATSGDLPQGRYDLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEI6</accession>
    <name>A0A0B1PEI6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative synaptojanin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000285">
        <property type="protein sequence ID" value="KHJ35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEI6"/>
    <dbReference type="STRING" id="52586.A0A0B1PEI6"/>
    <dbReference type="HOGENOM" id="CLU_006249_1_0_1"/>
    <dbReference type="OMA" id="YFWNRHL"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="270"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="723"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="981" mass="110949" checksum="D9012C44352217F6" modified="2015-03-04" version="1">MSSLVRKVLIYAVTEGLILRPIPQKDGQGPTSSIKIFFNNNKIITLQNGDCEEQVPDKCFEAYGIVGVLTISKSSYLLSIVQREQVAQIHKKPIYVVTEIALTPLASKAEAESSIGNYQSKFSKKTETLDKVECSDSEEDNENNDRSISTGQVVDNKEDPGEFPPLVSHRRTSNVAQDVMAKKGGYGRFANKWFSKTGWILDQRRSMGMTSQEDDKFTTNNTLLGANVESKEDKDEAIGRNEPLENKNKVGITENTLQKLLRTTQLLLGSSESFYFSYDWDITRSFATLKTHFNNLPLCEQALADYFWNYHLLKPFINAGYTSFSLPLMQGFVGQREFSMKLNPIEQISNLDGLGNMSNKLSQWSSKRRRSLHCKQNDSQDLNLSMQECSEAKHTHKDFLLTLISRRSVRRAGLRYLRRGVDENGYTANFVETEQVLSDPEWISSRRLSSFVQIRGSIPVFWSQSPNSFKPTPRLQHGEETNLRAYCTHIKNLKNTYGDIQAISLVEKSGPEAIVGIEYENIVKILNEASDQNINSDLVVGFEWWDFHENCRGLKFENINLLMEILKMKLENHSYSCIVDGNFESRQSGVMRTNCMDCLDRTNVTQSACARKILELQLLSENVDLAFQADQGTKWFNDLWADNGDAISKQYASTAALKGDFTRTRKRELTGALRDVSLSISRFYNGIVNDYFSQAAIDYLIGNATELIFEDFDENFMTVDPAISMQRLRQQLIELCQKQVISDEKEEIIGGWTLLTPVSPNIINITPLQESVLLITNLGLYSCQVNWDLEKLSSFERISLESIQNIKYGTYITSTLSVAQMDEERNVGLVITYSVDDQKKDAKDSQDSISENVHQENSIIDTIAQVAPAFPGRPVATAKSTSEDNIISKTRVLAFKALPSRSSVAVTAAEEEVEVKFSELEQIEMICLEIERLVNNFRSMEVGRPRPSLVEHADIISLAEAHKSTRLLDKLSHNLKKLVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEP5</accession>
    <name>A0A0B1PEP5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ubiquitin-conjugating enzyme e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000525">
        <property type="protein sequence ID" value="KHJ35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEP5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEP5"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_0_1"/>
    <dbReference type="OMA" id="CHPNVKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="18616" checksum="F6199493F12D3C45" modified="2015-03-04" version="1">MAKAIKRILTELTQFNSSLSDPSSSSSRYIESLVPKSPDNLLHLSAILSGQSLPPETGYANGRWLLSIDIPENYPNTPPKIQFITKICHPNIKWESGEVCLDVLQDRWTPVLGIVGALECIGRLLVEGATDSPLGIEVAALERIGDTIGKRSLVGFWCDEERWNGELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF93</accession>
    <name>A0A0B1PF93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative duf159 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g4477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000172">
        <property type="protein sequence ID" value="KHJ35985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF93"/>
    <dbReference type="STRING" id="52586.A0A0B1PF93"/>
    <dbReference type="HOGENOM" id="CLU_035990_0_3_1"/>
    <dbReference type="OMA" id="GMWTTMK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="407" mass="46408" checksum="0E739619A99B95C2" modified="2015-03-04" version="1">MCGRYALGLRPSEVFTALQNDGMEIHESLSSQDKDVPLPNFNLAPGNFGLVYLAQKHQYASGSSEEIVVESNCNKAQKDDPNLHKITYKLQVMKWGLIPFWTKRLPDYGTLLKTINCRDDSLKLNKGPWNSMKATKRCVIIAQGFFEWLKKPEKIPHIVKRRDGKLLCLAGLYDSVEFEGSKGIHYTYTIITTNSNRQFESFHDRMPVILENGSNELRKWLDPSITCWSQDLQSLLRPFDAELEIYPVSRDIGKLSKNYPRLIVPIASSENKSNIANFFGKNDAGATMGLNAINMKLEPKSEAIHTSLKSTFFKKDIEEKDQLELSSMESTALKRQSPKACGLGKKRILIDTYDDKQKKKVKSNNDIFKMEPPRSPSLMTKNIARKNRYTSSKSKIKECSKITKYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF96</accession>
    <name>A0A0B1PF96_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g2512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="JNVN01000454">
        <property type="protein sequence ID" value="KHJ35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF96"/>
    <dbReference type="STRING" id="52586.A0A0B1PF96"/>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="CIVECAY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="33"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="36471" checksum="CA854EC071ECFCD3" modified="2015-03-04" version="1">MFAARRTIFNSSFSARRAFTVSARDLKKVAVLGAAGGIGQPLSLLLKLNPRVTDLALYDIRLAHGVATDLAHINTKSTVAGYGPSEDGLAKALSGSEIVLIPAGVPRKPGMSRDDLFNTNASIVRDLAKAISISAPKANVLVISNPVNSTVPIVAEVFKKNKTYNPKNLFGVTTLDVVRASRFVSEIKNTDPDKEKITVVGGHSGVTIVPLFSQSSHPDLVNDKKLLERVQFGGDEVVKAKDGSGSATLSMAMAGARFTDSLLRAIEGEKGIVEPAYVDSPLYKDSGIDFFSSRVELGPNGVNKIHEVGNLAPEEQGLLKAALVDLLKNIDKGIKFVNQNPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFB5</accession>
    <name>A0A0B1PFB5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000167">
        <property type="protein sequence ID" value="KHJ36005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFB5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFB5"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="266" mass="28917" checksum="B090B95BD284E0FE" modified="2015-03-04" version="1">MADAPRGGAAQGGGFGSRGDRGGDRGRGRGRGRRGPRRGANKNEEKEWQPVTKLGRLVKEGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVIIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVVPIRRGYWGTNLGLPHSLPTKESGKCGSVSVRLIPAPRGTGLVASPAVKRLLQLAGVEDIYTSSSGSTKTLENTLKATFAAVANTYGYLTPNLWQETKLIRSPLEEFGDVLRAGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFL1</accession>
    <name>A0A0B1PFL1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitochondrial protein sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000147">
        <property type="protein sequence ID" value="KHJ36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFL1"/>
    <dbReference type="STRING" id="52586.A0A0B1PFL1"/>
    <dbReference type="HOGENOM" id="CLU_067902_1_1_1"/>
    <dbReference type="OMA" id="YCPWNEK"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20959" checksum="61F22702BE068F01" modified="2015-03-04" version="1">MKVFSNDEIFEYSWEEVSTANWMKYCPWNDKSTHVIAVDTLSRSVDAETGVLRTERLITCKQSAPKWLSSLMGGKETSHVFETSYVDPVEKKVTMISTNLTFSNIINVRETVTYKPLSTTRTQFSQDAKITALCGGWQKIKNAVEEATVDRFSENARKGKEGFENVLKMSRGVFGDQKLQQQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFQ0</accession>
    <name>A0A0B1PFQ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000133">
        <property type="protein sequence ID" value="KHJ36130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFQ0"/>
    <dbReference type="HOGENOM" id="CLU_2086575_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="117" mass="13308" checksum="7DD2EF9C5375BAF0" modified="2015-03-04" version="1">MQLQSLMNVVLGKEEKSEDGQVTKPTENKLPVRQYTENRLRTGLKRFLNRQSGTRTDALKSNNSFPHFRSQQKNKAYPIDELEGSEVNQSPAERLGDSDDDEELDALLSNLLNDNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFQ8</accession>
    <name>A0A0B1PFQ8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000130">
        <property type="protein sequence ID" value="KHJ36135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFQ8"/>
    <dbReference type="HOGENOM" id="CLU_1103460_0_0_1"/>
    <dbReference type="OMA" id="WGERWEV"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="252" mass="28075" checksum="4E0C4B519BAB396E" modified="2015-03-04" version="1">MVEVKSTQFVMDDPPPPYSAAPQKEEFRILPDIRSPKYERTQNHSHPNFAGSVNANNQSGHRFPKKFAIYHATGSAADFVITLHSDDPRILFYISGHAEASSQPSLILHSKPQASSPPLATANLHFFSETVAIKIYDNPSSVVKAQSAVTPNSNMIFVVQVPGRNQKEQFAWKSIKKRELGFFDSILNGMKLVNCQTGETLAMWTNATLSSKKVGKLSFLAEDRSKLGERFELMAVITLLSILERKKRKDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFU7</accession>
    <name>A0A0B1PFU7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000122">
        <property type="protein sequence ID" value="KHJ36170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFU7"/>
    <dbReference type="STRING" id="52586.A0A0B1PFU7"/>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ36170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="372" mass="40936" checksum="7CCDB9D1FB8292A7" modified="2015-03-04" version="1">MAEEDNQKNRSIVFFDISIGKNAAGRVFFRLYNDIVPKTAENFRALCTGEKGIGKSGVPLSYKGSKFHRVIKQFMIQGGDFTNGNGTGGESIYGSKFDDENFEVKHDKPFLLSMANAGPGTNGSQFFVTTVPTPHLDNKHVVFGEVLSGKSIIRKIEQLPTVPSDKPGKDVIITDCGELHGEDVENATRKIPDVTGDPYEEFPEDLNTAPTADEIIKIATELKEFGNCAFKTGDISMGLEKYEKGLRYLDHDVDWDSASEEIKAAVHPLRYTLNSNSALLANKIKDFKEGSNFASAALEVPGISDKDRAKALYRRAIALTGMKNEDDALIDLQQANKLLPGDSSIIHEMAAVRKIATERAKKEKAAYSKFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFV0</accession>
    <name>A0A0B1PFV0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000383">
        <property type="protein sequence ID" value="KHJ35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFV0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFV0"/>
    <dbReference type="HOGENOM" id="CLU_021766_1_0_1"/>
    <dbReference type="OMA" id="EPYKNAI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059119" evidence="2">
        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="567" mass="64384" checksum="F943E8EAAA468BBB" modified="2015-03-04" version="1">MLSIPKLLFLFFTSTTLAVENHKKAAPYLLEHNLTNRQHPLPEKQVQSPTYIAFVNALDVLQADYFRIWPGVWPTAIDWTSAVLGTSVAGALRTFSSSLSEVSSPPIAANIINRYFSQLSASFFGQDIFALQQQAFDDMLWVTLEWIESICFIEERSLDYTTSPIGGPWYGQQWKSDFAHRARVFWDLAAHGWNTALCNGGMIWNPRQLPYKNAITNELYISASIAMYLYFPGDNNNSPFQKTISNVPNTNFIHKPQDVKYLNAAIEAYKWLYAINMTNDDGLFVDGFHISGWNTTFSNNTQCDERNEMVYTYNQGVLLSGQYGLYVATGVRSYLEDGHKLISNVIRATGWDIDNANISSSLSKSNLKPQQDKWYGLGRNGILEEACDASATCSQDSQTFKGIFFHHLTKFCSTLTDPISTPRETTQSPQDIQDWHHNSCQRYGSWIKHNADAALRTLDSQGRFGAWWGVTANSTEYHTIKNNEAPIPSGAIDYRSNGIPQDWNVNNKKRREEYQRHDIVKRDNNDPQARDPNDRGRGRTVETQAGGLNVLRAFLEIVERPQDNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFV3</accession>
    <name>A0A0B1PFV3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000122">
        <property type="protein sequence ID" value="KHJ36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFV3"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="237" mass="26432" checksum="2007F27B71435DFE" modified="2015-03-04" version="1">MSLYQSPIPPIPPISLNSQSLCTFATTHPPPSSTIPATFILENKPIVKPVPPSKIATQRDAEPESRNEENSSHLYLPRELENIIATRHRQERAWHIRLSICACIYSNIDSTLAIYKKYIEKEGADIFRKNLQKATAFLDTSDNLAQPPKIPIELKPGKKKFSNSPSNAGLNDLLANLKPPNLPSQNFIKNLEKQVVPLKQKENKQAMVGRNGHKNSRTIEPVATSSIATGTRHQPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG41</accession>
    <name>A0A0B1PG41_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative wd40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000236">
        <property type="protein sequence ID" value="KHJ35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG41"/>
    <dbReference type="STRING" id="52586.A0A0B1PG41"/>
    <dbReference type="HOGENOM" id="CLU_024072_2_0_1"/>
    <dbReference type="OMA" id="CWHLNGD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="55662" checksum="1C1E3DD02F499770" modified="2015-03-04" version="1">MSVRMQSPGFNLQHIRHLRLWHLNSGISKMRKSQIVQSSSQSLPSPDGAYIAIILPSSLCIRETGSLNITQEISIPSEISVLWFLWSPSSSRILVGTKETLYIFSPTNSQALARIENLTSSSIKASFVTFSIDDDEILIFYDLGFKLSIINIITSESVDIAFIKLFSPATATKGFSFRPGTGNLTLLTRTGGKDIISLHSRGTQDVFRSWYPETIDTQGLSWSGDGKWLAIFESASLGFKLLIYTAGGNLYKKCQISAEILDLDPLIELGLGIKLIEWTPSRKYIAIGDYSDRVTLLQMPQFTYFMSFSHKNILKIVGSCPIWQEQTNLQGSGFKSEFTQTVKGIYLPTPSSVNNVKTGVSLMSFDKSGSLLTVKMENHPTTIWIWDVMKPVPRAILVLHATVSKILWHPKIDKQFMALCEGESAQGLVYIWNNSWLSPKIIDFASYFPDGRLIEKTISRWVHTKDLNSCLFFSDAQNCLLLWFQNTSESLNLCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGL3</accession>
    <name>A0A0B1PGL3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g1409</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="JNVN01000167">
        <property type="protein sequence ID" value="KHJ36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGL3"/>
    <dbReference type="SMR" id="A0A0B1PGL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PGL3"/>
    <dbReference type="HOGENOM" id="CLU_032444_1_1_1"/>
    <dbReference type="OMA" id="IQEVHID"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="359" mass="41076" checksum="1F66CE0725360271" modified="2015-03-04" version="1">MSIYSFLIAVRSNGEMLTNEDGETTSHLMGMFYRTLRIVDNGIKPVYVFDGAPPKLKSGELAKRFQRKATANENLEEAKETGTSEDVEKFSRRTVRVTKEHNSECQRLLKLMGIPFIIAPTEAEAQCAVLARSGKVYAAASEDMDTLCFNSPVLLRHLTFSEMRKEPIQEIFIDKILTGLDMDRDQFIDLCILLGCDYLDPIPKVGPHTALKIIRDYKSLEKFVEAVKAGKTKFNLPEDWPYQEARQLFINPEVFPADHKNCDFKWEQPDLDGLIQFLVKEKGFSEDRVRSGAEKLKKNLKSSQQARLEGFFKPVARTEEELKNLKRKNEAKSEQKKKILKEEKKLKAKVRVKPPRGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGN3</accession>
    <name>A0A0B1PGN3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGN3"/>
    <dbReference type="STRING" id="52586.A0A0B1PGN3"/>
    <dbReference type="HOGENOM" id="CLU_139931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="116" mass="13387" checksum="333963C969318C12" modified="2015-03-04" version="1">MDKENNWGIPILSGDNHDSWFRRYKVKLTGKGVFYVVEQTVSEAYRIASVDSLTKGVENLDLKQEQNSSTNRTEGLVNLEKKEKYLRDEATAIDYLFKSLSLDDQALYDEHDTAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHM8</accession>
    <name>A0A0B1PHM8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="JNVN01000086">
        <property type="protein sequence ID" value="KHJ36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHM8"/>
    <dbReference type="STRING" id="52586.A0A0B1PHM8"/>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="OMA" id="IAMSQST"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="260" mass="28709" checksum="2C10986A2F9352C5" modified="2015-03-04" version="1">MAKQPNLYAFSNPDALNTTLRNYIIQCQNAGINRHNCFKVAISGGSLPKNLANALLSTSTNSNDPIKFDKWEIFFADERAVPLTHEDSNYGLLKTELLDKIPESQGRPKVHEIDETQLHDTQELADNYEKILVRSFASRDSVKLPIFDLILLGCGPDGHTCSLFPFHPLLRESEAWVAPIEDSPKPPPKRITLTLPVVTHAVKVAFIATGAGKADILKKVFDDGQNLPCTLINEAVGERCSWFTDTAAVEGVSFPRRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PIQ7</accession>
    <name>A0A0B1PIQ7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000056">
        <property type="protein sequence ID" value="KHJ36359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PIQ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PIQ7"/>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="24027" checksum="C8D05B1A6A72EBB3" modified="2015-03-04" version="1">MNRLFGVKGATAPKPTLDSAINNVDDRVSSIDVKLAAINAELTGYQTKISKMRDGPAKKAIKQKALKVLQRRKMYEGQRDQLQQQSWNMEQAGMMQDNLKNIMITVDAMKQTNKSLKKQYGKIDIDKIEQMQNEMADLIDHGNEIQESISRSYEIPEDVDEAELDAELEALEDEVEFENLGAQNTPSFMFDEVPDFIDEAAPVNLDQVKETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUQ5</accession>
    <name>A0A0B1NUQ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005119">
        <property type="protein sequence ID" value="KHJ30107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUQ5"/>
    <dbReference type="HOGENOM" id="CLU_1797873_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="144" mass="16263" checksum="3A91923A60BEA282" modified="2015-03-04" version="1">MPTCQYKEHSQTNQGASANKNIKSKAATQITWTEIVRRRPAKNVVDLQTQEKVILPSIPPENTPKVISKPDPRLFLRMGQDHPWRRVSPHYIKISLAEKLEVASSAIIQVTRVNSGYAVSAVSEIMRNALLTQAHRLEKTELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NUR5</accession>
    <name>A0A0B1NUR5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005075">
        <property type="protein sequence ID" value="KHJ30117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NUR5"/>
    <dbReference type="HOGENOM" id="CLU_1195639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="232" mass="26200" checksum="7B0458C0CC7CEFBA" modified="2015-03-04" version="1">MKERKIAQEWDLDQFFLHLEDLFVYNNAPNRAQAKIYAIHQGPKQLFAKFRSVFEQICSEANFLAPIGPAKVNAIKTALSLHLKRGIAYRKAISYVNYDSFIIEVQDLVAGLEALPKFRSGQGSATEYNIYVNLIVDSSLAPQQVIQSTTQAPEFDLDRDVQMSGVNNLQVHLQAQSQAIIAALRSGNLNSSNNKNRINDTRLNHPPLSQIERNRRIEAKQCERCGKSPSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW71</accession>
    <name>A0A0B1NW71_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01004742">
        <property type="protein sequence ID" value="KHJ30218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW71"/>
    <dbReference type="STRING" id="52586.A0A0B1NW71"/>
    <dbReference type="HOGENOM" id="CLU_002833_1_2_1"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="362" mass="39687" checksum="D904FA3F058320D0" modified="2015-03-04" version="1">MPHEVQSQISQYTFQSNIFQPARTNAIYYPNWRARDGQTPATLNFNCINFVYYAFANVNPDGTVTLSDEDVDLRMSVDGTSGCINSLMRLKKQYYYLKVILSIGGANGSQNFSSVASNAAYRDNFARTARGLVEGLGFDGIDIDWESPKDPQEGNNFIALLAAIRTQLPPFRYYVTAALPAGEWALQNIDIYKSQSYLDLINLMAYDFNGSWTTRSGYQSQLFSSKPDENSGDKAVHYLLSKGFPVSKILLGIPVYGRSFLGAAGPGQTYTGLGGNDGAFAYNSLPRPNASENVDRRLVSAYCVGGDGGFISYDNPDTVKLKANYCNAFGLAGLFYWEATQDAGTGPRSLIYTGFNALNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWB3</accession>
    <name>A0A0B1NWB3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004643">
        <property type="protein sequence ID" value="KHJ30253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWB3"/>
    <dbReference type="STRING" id="52586.A0A0B1NWB3"/>
    <dbReference type="HOGENOM" id="CLU_002055_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="397"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="697" mass="79686" checksum="389A25E018FD69F5" modified="2015-03-04" version="1">MPEESLSSVINNIRGAIGMSASHESNVDEAMFVNRKFHNEKRNGFQNKNSRFEKSYNQPTKSFDPRIKRCYCCKKIGCRSWKHTEKEQRDAKECFYQRHTSDNQKKFQQFLIEYEGITDDDLDEEKMILDKISVEDNEEPISGLFITAQDYDYSDQETNQTYTTSQYINNDDTFNISLLSFLQDQSVFHPITGKIPLAYKRLSNRKERYNDGLWQGVMVDMGAGKYSTAGYRQYIAYTRNFGPAELNTTIKVSVAFGKGSTCNSLGFINICTPIGKVDFHILDSDTPFLLCIADMKRLNFYLNNLDDKIYSKQLTIHGETYKQISSVKMKFGHPFIRWEPVNYFLFASCFITSVENSQDNVELVNDKLKLTEQQIRRLHKRFGHASVSKLGNLLDRAGYIKFRHHLLKIVNNYIFFIESRPVLHIIDEATRFQAAKFLKGQSTNDVWNAIRQSWIDVYVGPPDLIVRDAGKNFTSKEMQQLAQSIGTGTKCAPVEAHHSIGLVERYHEPQNDTAGPNGITPTILVFGTYPKISEPHASNVSIIQSVNAIRKVSAEIIKLCAEKQVRNALNQRNGPEITPIHNVPIGEKVWVWREIGKWTGPYTLLEMNGEDCIVDLPSGPTKFRSTSCKPYYKNENMESESDKINNNKINDTNDSNDSNDINEINDDDNTSNSNNKSNDNDNDNTSHNDHTKDNNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWV7</accession>
    <name>A0A0B1NWV7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative phd transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004198">
        <property type="protein sequence ID" value="KHJ30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWV7"/>
    <dbReference type="STRING" id="52586.A0A0B1NWV7"/>
    <dbReference type="HOGENOM" id="CLU_031143_0_0_1"/>
    <dbReference type="OMA" id="TIYKKTC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="471" mass="53281" checksum="410F01D28C9229E2" modified="2015-03-04" version="1">MEKSSLQALSTTQMSISEKVKAEGGRNRKTYLNALASNGTAQTFSNNSHINSDKEVAKKPSPNPIKKSGPKSGFKVHSKKFKKEAGRTSSETDSVLKNDGQSESEYSHDGVEYCICRGPDDHGMMVNCEGPCKDWYHCSCVGIDVEDARELLDRYVCPKCSSDDFLTTYKPMCRYHNISGCRKAAQIGLKPNPSMYCSEQHRREFWDYVVGKFRSGDPSTVIGVLSQAEASSLARVCNNLSEWQSLGTRPDMESQNITNPNGSNRLELLTSEEAGRIEWIHAQKTILKNKAELVRAQKELLIMIHEYCKSISSHPKLEVKDFCGYDNRLSMNEAQFLRWKNTEEGIMAFKTGKIRPQIPKTEPISTPCAYPDNVQMSNQLFELPNMTTNKSTSGSTTMAIDELQGLCLKPRKKCKHNGWRDIHCGDYQLMISNYEEDMARLQSEEEEIIKEAELREATKDYYAHNVTIQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NX26</accession>
    <name>A0A0B1NX26_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative duf1339 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003462">
        <property type="protein sequence ID" value="KHJ30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NX26"/>
    <dbReference type="STRING" id="52586.A0A0B1NX26"/>
    <dbReference type="HOGENOM" id="CLU_002060_1_1_1"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="873"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120078" checksum="5896EE97CC45B2B8" modified="2015-03-04" version="1">MYWPAGAPRIYSANSSDSTRQIIEFIDRSKSYTIVEGNNFYHPNENEKALCDENADDLERLTSKSETATPSTLKTPILTTNSVSQDNKLSHNSSHLTVKGNPSINLDDQSLLSLKISRSGHLFAVISSTSLTIWQTKPTVILAVVVRSKESINTYGSNFSLLMRPDSTILAILTTAGYLITYSIVSKPNGRAYRSFIPNNSSSYTRVQKKYDGNRNKDDYDVLWGPGEGDGVREVDISFRLVVKFNTGTGQMLALDDELIISTREPSSVQCIRWTPDSFEGQTITSLLSHIEWLPKKSSILEMIHDCPMNLSTWITSDGKAYAVQKLKSSRDSVTSLDKFKGYCFHVPNSPQKFAIKAAINARFSLIAIGCLDGTIQVYSAKDYVGNIPPSHASKAIVSEITTGALTCLAYSPDGYCLFAGYEKGWAIWSVFGKPGASSFANDQAISRVQDETWLEGVKEIVWISGGLEILMISHQDHRIWVLEMTRSAISSCYSSANISRTLVQTTSTISVYRGYNQLDSSIVPTEPSLWHVAQVPPSYLAGQWPIRYSVISPDARYIAVAGRRGLTHYSVSSRRWKTFADKIMENEFQIRGGMCWYQHILVAAIETENVYQLRLFSREADLNISSVLYTESLPAPVVIIAPSGEDSLLVYTYDNILYHFIFVQFSDKLKVLQVGQIAFHGIIRSPARVRGLSWILPNDEIFLDDPSQEVACASVIFLYDGKLVLLQPIFGEERELRYDMRVIAQNVEYYFLMRDVQVTIFPHQKIGLNSPLLGDDDSLLNHQEESSLYNSLWIFEGNEIKGWPNVKDLLQVTSSEIGREISTMFSIPVDFYPLSIQFERGIILGLESELIQTRNINFTLFKLAIRTRLFIPQVLQFQLSQFDHTAALNLAQKFQGLDYFAHSLEILLYNTLEQEVDTRSPTESILLPTVLSFLSMFPQFLDIIVQCTRKTEIRSWHTLFKYLPPPHELFEESIKKGSLKTAAGFMVIVQTLDESGTSSELLIRLFLRAKNEEDWTLCEELANFLIALDPSGDILSGAMEILCLNDPSLQNEKLQILLEKIKAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NXP7</accession>
    <name>A0A0B1NXP7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bel1-like homeodomain protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003178">
        <property type="protein sequence ID" value="KHJ31167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NXP7"/>
    <dbReference type="STRING" id="52586.A0A0B1NXP7"/>
    <dbReference type="HOGENOM" id="CLU_967076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="32400" checksum="2763DC52FBE8AA86" modified="2015-03-04" version="1">MLLAQKNSSTYRGSGTKITEFNHKLLSDFTEHNTASLNCGFPNNNDCILIGNELAEKETCILVEVILNLLITGHIGQEFRGVSIVKPERRYQKAPLSKIIPSLFSSEFSLLIANNSRFLPTITNAFTKSLIRNCLSPSFQNKLLQIFSFSSIDEFEANAKQALGLMDARLWVIVQKSLNSSATSRKIWSHNYRSSKGKLIRNSASISSKGEGDIDCEDVTRDSDQSFESLEDLLANLNDPDLLRYDQEQMLLDYETRELLISSGPPKSPSLYEAFTFEDTSEEDFMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYM3</accession>
    <name>A0A0B1NYM3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01005018">
        <property type="protein sequence ID" value="KHJ30135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYM3"/>
    <dbReference type="STRING" id="52586.A0A0B1NYM3"/>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="OMA" id="YFGWARQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ30135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="34882" checksum="B69354EF29304425" modified="2015-03-04" version="1">MATNSVKLITGNSHPKLAMLVAERLGIQIAKTMCLNYSNQETSVTVGESVRDEDVFIIQSTAPGDINDGLMELLIMINACKTASARRITAVIPNFPYARQDKKDKSRAPISAKLIANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSTLRWIRENLDVNSCVIVSPDAGGAKRATSIADRLDLGFALIHKERARPNEVSRMVLVGDVENKIAILVDDMADTCGTLVKAAETVMAHNAREVVAIVTHGILSGNAIDTLNQSKLSRIVVTNTVPLGNKVEQCSRLRVMDISPTLAEAIRRTHNGESVSFLFNHAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYY8</accession>
    <name>A0A0B1NYY8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004679">
        <property type="protein sequence ID" value="KHJ30240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYY8"/>
    <dbReference type="STRING" id="52586.A0A0B1NYY8"/>
    <dbReference type="HOGENOM" id="CLU_054132_1_0_1"/>
    <dbReference type="OMA" id="VMVFLFR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="223" mass="25219" checksum="BAB2BFDD34F99987" modified="2015-03-04" version="1">MYRTDRVIIKQNLEEIILNPKNAELLAVLKAARNGAVYGAKVRFPHALVITLLYRSGSLREKLSAVFKATRTHATNLATFAIIYKLTLLILKQFSSDPRKDGTYDTFIAGLIGGYLVFGRRTAKGRVSSVSKQIVIFVFARVCLSLAQVLVKPAVGIIKDHQLSAKISYDAWPIFAALSWGSVMWLFKWYPETLQTGLRSSMDYIYVQSEQWDSLRNFVIHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ86</accession>
    <name>A0A0B1NZ86_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EV44_g2462</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01002638">
        <property type="protein sequence ID" value="KHJ31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ86"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ86"/>
    <dbReference type="HOGENOM" id="CLU_014815_3_0_1"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="21">
        <location>
            <begin position="327"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KHJ31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="594" mass="68061" checksum="9DB6F9EEE814E709" modified="2015-03-04" version="1">MTEYNRGKRAAEEGNDEDEEDIDETKYMTQKDALLFAIEVNRGMLSSQLEKDSATVASLKCIYQIMQQQIITSPKDMMGVLLFGTEMSKFQEDDKQNDLTGLDFPHCYLLMDLNIPSAEDVNLLKAIAVGEEASQDILNPSTEKVSLSDMLFCVNQIFTNRAQKYGSKRLFIITDNDNPHEQDKSIRSQAAVRARDLYDLGIMLELIPISHFEHRFDRTKFYNDIVYRDPTEEIDNAMMPSKDLNPDEDDSISFLNKLVSDISSKKVAKQALFSGLPFEIGPGFQISINGYNILHKQNIAKNFWVYDGGEELQIAQIEGGMMTDDTAVPINQADITRAYKFGGTQVYFASKEEKMIRFFESPILRILGFKSKYEIPIWMSMSKSIFIYPSEEKVVGSSRVFSALWKKLLTSEKVGIAWYIPRVNASPSIVAIVPSKQLESNTGKQIVPAGLWLHTIPYCDDVRETPSILPPFTAPDVLIDEMRNIIRQLQLPGGIYDPWKYPNPTLQWHYRILQAKALGEDILNMKREDKTEPRYRQIEKRAGNFMRRWNKILEEQITICQRNFYDTNSNIDPKTEAGESIEKGDKKFKVKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ91</accession>
    <name>A0A0B1NZ91_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g0097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002634">
        <property type="protein sequence ID" value="KHJ31712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ91"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ91"/>
    <dbReference type="HOGENOM" id="CLU_082177_0_0_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ31712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="28575" checksum="C4B1819705028490" modified="2015-03-04" version="1">MNTLALRRIISSRKKACAKNSFSAPLVAFSITRALPTENSKSTPESELEKITLSSNRLRYPNKRNSFDITPPSNESSTDLSENPIQVDARPKQNNFTRPSGAYRLMKNSIESTKKTVDKYKEYNGAIDLSSQIYRQWKIGDVYAPHDLHQAELSKYRLRAAPTFDMFDVLNMNPLEHYRNFSIMSEWMTPMGRIKPRKETALRPVNQRRIAKAIRRSIGIGIMPSVYRHPEILYKDLKRYESDPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZA5</accession>
    <name>A0A0B1NZA5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative er membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004432">
        <property type="protein sequence ID" value="KHJ30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZA5"/>
    <dbReference type="STRING" id="52586.A0A0B1NZA5"/>
    <dbReference type="HOGENOM" id="CLU_027878_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="352" mass="38766" checksum="6D3D5A07FBBF9005" modified="2015-03-04" version="1">MNQFATDANGSGDWVARSFERKRISSLSLLGSGGLVEVLTVGTWDKLLQYSKSIFQLAEGFCSLLAIQAAGQITRWLVNKGRSDSWMITLLVFSASIISSSVYFLWRISNFPEISNVDASLIGAAVTCAVFLCAWGIGSGRGNPVESSLLFAYVVLCIYQIFTDYLPISDSEITEPITQAEFPPFPPMIMASYSTILYMMSTLPSAVLSSFDFLFAAFQAVTPSILISLAYRILVFYAATRIIPAIRESGAQAFSEEPNLKESGGTVNFLGLLSWFSPSILVAVYTSLLMQHFSVTSAENNPTKWWEMQGGNSSGNIWRWINVTATMALYALELYLGHGDLDDTIINHWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZH7</accession>
    <name>A0A0B1NZH7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004250">
        <property type="protein sequence ID" value="KHJ30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZH7"/>
    <dbReference type="HOGENOM" id="CLU_041336_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="308" mass="34458" checksum="20E456AF9F9F1951" modified="2015-03-04" version="1">MASMNKYYSSLPTIPPYIRKEQGVVEVSKIMLGDEVERVCSMRPAHLKLYGRNKAEAPHRTWMAFFSKAPSSSFKVFDESGVARKFKKQQPLDFCKRCNGHHPTKNCSRVPSCGNCGSTNYAEDLCMAVTKCRNSGGPHRSDSRRCLARPTRSGAPTKEQLKTYRQAGEREFLALLRAKAAEESAATAENKNKNVISSQATVPDPSIDSDPKGHYPLQDVINFLSINVGRGSASQDIAMARACELRIDVLLIQEPWWSGRTKTHPYYDLYLPFGGENIRPRAATYIRKDPKIIVAKQTYPLSLTGDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZL4</accession>
    <name>A0A0B1NZL4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative guanyl-specific ribonuclease f1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004144">
        <property type="protein sequence ID" value="KHJ30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZL4"/>
    <dbReference type="HOGENOM" id="CLU_1090683_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="305" mass="34693" checksum="A00AABFD411FB919" modified="2015-03-04" version="1">MILLSAGDMIILNWRLKKKKLTQSEAISVVLDKGGPYMILMDPFGQLKRVIVRTYDYDFVDCIASSTEIPAYVSHSNGEVSTKSKGITRSGFDCNGIFFDEKELHLARNLARESGKSRHNVYPMEHFSPPCDSPCLLWPLKPSGSMIRNGNLAPYRLVMSLDFQILFVALKGREKMKKCEKRTIAGGNINHDQSSFRCGKMVFHNSELLPVVDKACKNIMLHLKKYPMSYEGENFQVPGPYLIYPLMKDKEYIRGWPGLYFIVMNYDCVLAGVLMTRKKYILQTNSASRKVSKTSVKCVAFQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZR1</accession>
    <name>A0A0B1NZR1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01002541">
        <property type="protein sequence ID" value="KHJ31837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZR1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZR1"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="48"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ31837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="383" mass="42072" checksum="BA2F2973301A9D93" modified="2015-03-04" version="1">MFSYNSTRLGRRLLQKSSKIPQNQLNSRNLATVQSDIFKPTKYGGKYTVTLIPGDGIGAEIVDSVKTIFKADNVPIEWEQVDVTGVETGEKNSEDLFRESIASLKRNKLGLKGILHTPIERSGHQSFNVAMRQELDIYASIALVKNIPGYITRHQNVDLCIIRENTEGEYSGLEHQSVPGVVESLKIITRTKSERIAKFAFAFALANNRKKVTCIHKANIMKLADGLFRNTFKTIAQDYPTLEVNDMIVDNASMQCVSRPQQFDVMVMPNLYGGILSNVGAALVGGPGVVPGCNMGREVAVFEPGCRHVGLDIKGKHQANPVAMILSGSMLLRHLGLDEHANRISKAVYDVIADGKVRTRDMGGNNSTTEITRAILDSMELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZV3</accession>
    <name>A0A0B1NZV3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002493">
        <property type="protein sequence ID" value="KHJ31892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZV3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZV3"/>
    <dbReference type="HOGENOM" id="CLU_004390_2_0_1"/>
    <dbReference type="OMA" id="MEHYYEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="556"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="735" mass="85088" checksum="D3C8E50515533232" modified="2015-03-04" version="1">MESADGERDFVDPDVRAHVSSIVTAIGGSGADENGHYILGDDALACLRDLKRWLKLYDEKVNRFDVARCLAELNVVGGDILQILAAWPEYESEDRLKFKAALSCLELLVPLTWPIKKDPNEMTQNHHRHIPYLQIAQLGYKRSILNFDGARILHTTVRCALPSIAEPKNERSSRDEGIIKLLLYFIRNIAMIEPPKSINFDEENLEISRSVLIDTFHYQDIFHLILSVSSMMGEEFEVQDVIVLDIIFHIVKGINVEDLFSREKNREDLKIDELKRLRKKEAAMLSTYQNNAPTRHNRFGTMAWIQREDAKMATISSPAAIVSSVKSYAKMDSTKKYKPPQKSFKDQSGPFDFYTPVVLSVQAKKNLLKFVEDFLDSCFNPFFSHIRKTIDREEDRVQDFHPTQFFYLISWFLKADRSRKARHIENKDKQVNETEELGNFSLIASVFSQEMFITLNRFMNSSFESKNWLELGAALKCFSQILVSVQEMNQSSIEEDREIASNILSRIFYEESIHDLIASVTRTYKDQGFGYLESVTETAQNYLRVLENYSKENTDLQVRSKRKSRRKKEKDKADKLSQDVRSGDEDNDFSGDDENDDDDSIAVNVSRERKLDFKRVSSRFVTQGCVDTFVTFAHYYQELEPAQLKRVHRFFYRVAFKNDMSVMLFRVDIIVLLNKMIKGPDGLDTDSAVLKEWEELVRQIFKRCLRKIQERPELVVEMLFSKTNSTANFLNGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX4</accession>
    <name>A0A0B1NZX4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005029">
        <property type="protein sequence ID" value="KHJ30129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX4"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX4"/>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="468" mass="51679" checksum="0EA4EE237FDDB9F1" modified="2015-03-04" version="1">MDEIAPEYDVVVLGTGLTECVLSGVLSVKGKKVLHIDRNDHYGGEAASLNIESLFKKYGNFNPGEEPWKKYGRVNDWNIDLIPKLLMSSGELTNILVSTDVTRYLEFKQVAGSFVQQGSGSKATVAKVPSDAGEALRSSLMGIFEKRRMKTFIEWIGTFNLDDPACHKGLNIRNCTMKDVYDKFGLEASTRDFIGHAMALHLTDSYLNEVGRAPETIERIRLYGNSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTKIDEVVYEGDKVAGIKATMQDRSDEPPMKFETKTKKIIADPSYFPGKVKVTGHVLRAICILSHSLAGTDNSDSAQLIIPQSQVGRKNDIYIAVVSSAHSVCPKGYYIAIVSTIAETSTNHHLELEPGFERLGKIEEKFMGPPIPLYAPIEDGSKDSIFISKSYDATSHFETTTDDVRDIYQRAEGHELVVEGLREGTNLVSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P018</accession>
    <name>A0A0B1P018_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1784</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01002436">
        <property type="protein sequence ID" value="KHJ31972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P018"/>
    <dbReference type="SMR" id="A0A0B1P018"/>
    <dbReference type="STRING" id="52586.A0A0B1P018"/>
    <dbReference type="HOGENOM" id="CLU_002664_0_2_1"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="157"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="990"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="621"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="758"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ31972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116959" checksum="E887029CBB7CB942" modified="2015-03-04" version="1">MATTNSSPTPFEVQIPLCHQLPRPRQSSAITPRYLSLRTKSDILSSTRQKPPTNIHVPSRHLFVDDLVSLPNYVTSKVLEGSKGSFNREKPSSSRTEIPTKSVSRQQHRSSRHYQSEMTTTVSNDTGPVPIVTTHESRHGGRSGKSRTTIPVASGNWVMGKTIGAGSMGKVKLARKLETGEEVAVKIVPRGSTDDVQHQSKADRERADHSKEVRTAREAAIVTLLHHPFICSMKDVFRTTHHWYMLFEYVNGGQMLDYIISHGRLKEKQARKFSRQIASALDYCHRNSIVHRDLKIENILISKTGDIKIIDFGLSNMFNPRDHLKTFCGSLYFAAPELLQAKQYTGPEVDIWSFGIVLYVLVCGKVPFDDQSMPALHAKIKKGVVDYPSWLTPECKHLISRMLVTDSRQRANLQEIMNHSWMIKGLGSSPENHLPAREILHTPLDPNVIHAMTGFNFGPPEIIHSQLTEIVESQEYMKAARQLAQERESHGQPKDPEKKRSFGFDFYKRRSYSNSRDNLPAQNSEGIAPPKNDPLNAFHPLLSVYYLVREKQDRDLLAVNTPRVPNETPTQVAEIKAPKSVYTNPATYEMSGENATGGRSRPRARTHGEDEVATTLANMKKIDCPDPQSPSIPEPPPGHSRKGSTAAGILRRFSTRRRKEVSEKNQPPIVTAQSPIDRSQHKNNISIRRTQDRNSEVHLSPTSINSSHSRHVTTFAPLTSTESNNISPKDLTRTPSLKSESIRSRENRLGASDFMQHFSKDNLPANGTKNHLVHEDHVRSKYPPKTYLNSRKASRARSLGHARRESIQARRALREAQETQISEQNNIETGNTSSPSNEGVDHSENLKPVFLKGLFSVSTTSTKPVPVIRADIIRVLKQHNVKYKEIKGGFHCYHTPSIDLKKVYDLPPNTHNNFLSGHRRKISLGTLIGGSSERDRDDLERSPQIFRIPSRQPRATSITNFEISAESIHRNERGSTAKVAGETSTHVQSDLGESMILEFEIFIVKVPLLSLHGIQFKRLVGGTWQYKNMADQILRELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P022</accession>
    <name>A0A0B1P022_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002431">
        <property type="protein sequence ID" value="KHJ31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P022"/>
    <dbReference type="STRING" id="52586.A0A0B1P022"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_3_1"/>
    <dbReference type="OMA" id="MESNSAM"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="215"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="520"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="762" mass="84561" checksum="70E2B031169B1A20" modified="2015-03-04" version="1">MVGRRSRVSLVDSFDREVYQVVCKLIDEQEKLEISSKAITVNSIYENIRNSNSSLKRRNKRNLEESIERALQILRQDIQEESDNSIPTENLVEDLHESNVVNKSITKMWSNPSRAIPISSPRGSVQLAETVDNKILPLSSQIHQESTSKLDRQTNGEPKLKRRKGEFKRQIDRSPPTGISLDDLGGVEDVIQQLIEAVAIPMLYPEIYLEIGIEPPRGVLLHGPPGCGKTMIANIFAAEIGVSYIPLSAPSLVAGMSGESEKKIREIFDEAVKVAPCLVFIDEIEVIMGKRETAQREMEKRIVAQMLTCMDEISLIKTNGKPVMIMAATNRPDCLDPALRRAGRFNREINLGVPNELARGKILKALTRKLKLADDFDYESLAKLTPGFVGADLNDVVSVAGTDAIKRVMNVFSFRLNELREMDIDNNDQSTESHPILMLRSLVLNADLPSMSKDFSISYQDFISAIAKVQPSAKREGFTTIPDTTWSHIGALHSVREQLQMTIVEPIRNPEAFASVGITTPAGVLLWGPPGCGKTLLAKAVANESKANFISIKGPELLNKYVGESERAVRQVFERARSSIPCILFFDELDALVPKREDSLSEASCKVVNTLLTELDGLSNRTGIYVIAATNRPDMIDPAMLRPGRLGTSVFVDLPTESDRVEILKALYKNALPLVTEEEVLLLENVARDIRCTGFSGADLSNLHQTAAIAALKRNMIVVNGVSKYVGDLKIAQSDWEVALDTMRASVRDVKKYQRLKERGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0B9</accession>
    <name>A0A0B1P0B9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004492">
        <property type="protein sequence ID" value="KHJ30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0B9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0B9"/>
    <dbReference type="HOGENOM" id="CLU_1391163_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="196" mass="22543" checksum="D89B4224ADEE9EBB" modified="2015-03-04" version="1">MISKHFTLTTFKTKHYRFFATNNRLSKADKNSSYQKTTLVTLKKPVEPENCCMSGCAHCVWDIYAEEMEAWVNHKNSNTISKLHCEQVDLVRNSNARGAQQGEKVIRDQNSRRVLVSENTSLDSQATNQTDSVADENSTSARNNTPEIAKKNEENIIHTSHDDDDRISHLPVEIREFMKLEKKLNARKFNNKEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0H2</accession>
    <name>A0A0B1P0H2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004313">
        <property type="protein sequence ID" value="KHJ30406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0H2"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="104" mass="11517" checksum="D25289493B083B72" modified="2015-03-04" version="1">MHTEDLCMASTKCKNCGGPHRSDSRKCLARPTRAGKPTKEQLKIFRQAGDREYQAIVRAKIAEERAATIESEMDIVTNSQSENTATENSQASSVESSTEDARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0S0</accession>
    <name>A0A0B1P0S0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01003495">
        <property type="protein sequence ID" value="KHJ30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0S0"/>
    <dbReference type="STRING" id="52586.A0A0B1P0S0"/>
    <dbReference type="HOGENOM" id="CLU_041220_2_0_1"/>
    <dbReference type="OMA" id="ANYRTWC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="11">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="381" mass="43466" checksum="B7AE97C0FEB20D82" modified="2015-03-04" version="1">MGKAKQNKRNNASTSSLPYSKAVKAVNNVFKFNTNVGQHILKNPGVAEAIVSKAFLRPSDTVLEVGPGTGNLTMRILEKANKVIAVELDPRMAAEVTKRVQGKPEQNRLEILIGDVIKMESLPRFDVCISNTPYQISSPLVFKLLSLPNPPRVSILMFQREFALRLVARPGDPLYCRLSVNVQFWSKVTHIMKVGKNNFKPPPQVESSVVRIEPKMGSERPGMSWEEWDGMLRICFVRKNRTMRANWLGTKEVLALVERNYRVWCAINHITIDETTLEVAGDDRDEIMMDKEDEWNGFMDIDDALDEVPEFLKEEQNRARIKAGEKTPSKKKKTRVAELVKEKIRRVLEITDLTEKRPGKCDENDFLKLLCEFNKEGIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P129</accession>
    <name>A0A0B1P129_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alba domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002181">
        <property type="protein sequence ID" value="KHJ32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P129"/>
    <dbReference type="STRING" id="52586.A0A0B1P129"/>
    <dbReference type="HOGENOM" id="CLU_085444_1_0_1"/>
    <dbReference type="OMA" id="STKSPFM"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="194" mass="21591" checksum="96EE4B8CDB06897C" modified="2015-03-04" version="1">MDINESKVTKSDPTLIKKLPRLSKGFRISKRPLLHPPIASRYSSTTTSKVIYISNKSSFIGTIKRVRLFLEQIRSRSFGNDNNHIKNNSTSLLSQQQNSTSNDVVLTALSKAIKEGENKNGKKIRDEEVIMKAGGKAIEKGLRLAAWWSSQSDVKVELRTGSVGAVDDIVDEDGVEESSRVRNMSYLEVAIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1I2</accession>
    <name>A0A0B1P1I2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003204">
        <property type="protein sequence ID" value="KHJ31150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1I2"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="SKMVRVH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="420" mass="45392" checksum="9E5A374854BD1E39" modified="2015-03-04" version="1">MADIAKSRARARLKNKGLASDLIDIDAIESAIKQNYSPGIEMIDEEIDRLIAIGLESSCWATKGPAISVENSTPSIYAVEKPKSTDRVDLPLPSPTLAVQIQQHRSPTNEEPTKRRAAQTAANIEVCTVAINSVEIALAPLATGIQNNFVVSLKVYLRSAIAHFLRSGTAATPPTLPSRPSGPLPAVPIIKNTARCAPPAKVNPPSNPKSKSGGTWATVALKGHQNSPVTASTTQNAPLQRTKNNLVNHTASSGPDERLFLRIDKNHEWRLLAPSGVREILCEHLSCTPSDITHITRTPTGFALTVKGKETRQKLLNDSDGISTQGAKLEPASDLITYRIATVPVALRTSNRSVTVDDTNLTSEIVRVTNVASKMVRVHGKTRVGAPHRSWLAHFPRDQASRPGFRLFDESGVAVLYKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1I6</accession>
    <name>A0A0B1P1I6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aaa family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002342">
        <property type="protein sequence ID" value="KHJ32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1I6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1I6"/>
    <dbReference type="HOGENOM" id="CLU_004471_1_0_1"/>
    <dbReference type="OMA" id="FDWENKY"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="690"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="912" mass="104778" checksum="6CDB68FC7CB547CE" modified="2015-03-04" version="1">MDNSNTKTMDDRETTDRQEGAASTEEVTNLTTTINLKSKNGSKTESRNTKSCTGKKKEKVQVKKSRDIVSSSSESSDSSAESSSDSSDSSESSDDSEDEVKKKKDKSGCLSKRNKSNEKKRTKKKKPENEGIPSLEMKSSLIDLQKEFLRVQIQSQKLQLQRSQRFAQEPNNWSYQGTNFPSTDAAQLANLLCNSPVSKKATIEEEFKKKNFGSKVEFKRIDHWFDKETHRYKTTDSNENHDFYKYDQYLFNVRKEFDFDGRYQETRVDIKSKILKGILKKVMEDDRYTSFAEKEPTVRPNMLFLFLEDLRKYYKELKILKKRGKKTNKKAQKLMELKLKHLKVLIKYIDTDYARIKRTLYPMLESGVINYDLLWGLYKPGTIVCTPTYGSRDYLRAFKVDVAEKIVCMKLGQFYLIKGKYLEYDGKTWGKGTIEVSVPIFKDARRITSLECYPLQYHENSEKLRNDLISRGKKFVSLQGVHYKVHEGMAYLQKKKDVAKINVKSRVMVDPALHRRYFPNYPISSVMPNHSTRYLNQFGYESDINGKDCDDSDEDSCEEFDHRTCSENDCEQKPKAHPGREISKTKELEKIPNKTSDEIGKFGSDETSEIPIFTDEEYVIASPVVLGFSFNDKMWLEFTVSGIEEIVWNDKAFDSLVLKEDTKSILRALVESQKNSPTKNIDDVIRGKGKGLVAVLHGPPGTGKTLTAEGIAELLKYPLYTVSAGDLGHDATRLERQLQTILDMAYSWGAVLLLDEADVFLEKRNMADIHRNALVSIFLRLLEYFQGILFLTTNRVETFDEAFRSRIHVALRYQELSSKARQSVFKIFLDRAAALKDVSVAPFTDKDMNELSKQNLNGRQIKNTIRTALALAVQNNETLSMSHIQRVLNMSKEFERHLHGGPGFEDAMRGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1K6</accession>
    <name>A0A0B1P1K6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003155">
        <property type="protein sequence ID" value="KHJ31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1K6"/>
    <dbReference type="STRING" id="52586.A0A0B1P1K6"/>
    <dbReference type="HOGENOM" id="CLU_036943_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="226" mass="25127" checksum="CB0F37A25C2E945C" modified="2015-03-04" version="1">MECEDKLQTREENKFNFDEGCPPLTETADSTYNIVDQNKSSPQETSAAPLMAAIKGLLDMTNDYLQNLDKENPGIGADFLALLADGASRAMRGERVYAILHNTSKLNTNSPKATRAQKVASDVHEFKSLGKKQRLKASHPGGQSKEDRRVIIRLSSNHEARKTESFELWQKVQSFLYDKSLITDAIFFPSGVAILAPSPSKAATLMQFKDTIEKIFGEATVERQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1P1</accession>
    <name>A0A0B1P1P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative n amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003115">
        <property type="protein sequence ID" value="KHJ31215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1P1"/>
    <dbReference type="STRING" id="52586.A0A0B1P1P1"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="OMA" id="DAGRLMF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="53"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="474" mass="51258" checksum="BA87D26B57C0DC9E" modified="2015-03-04" version="1">MAVYQNSQKSSKEKVPSLSGSGPFGGKAEIGEVLDISDIEKHDPGKSDDRFHRLGWKRLTVVLIVEAIALGSLSLPSAFATLGLLPGVILCVFIGFVAIYTSYVIGQVKIAYPQVSHYTDVGRLLMGNFGYELISVMFVMQLLSVTGSHSLTGAIAFGNISDHKACSVAFSAISALLLFLVAIPPSFSELAIFGYIDFASIIIAIGITMIGTGVAWSRSENVASATGALASSPWSYWPKEGLTFVEGFVALGNIIFAYCFAVCQFSFMDEMHTPTDFPKSVWALGIIEMVIYTVTGTTILIFVGNDVQSPALLSAGPTLSKVAFGVALPVIFISGSINTTVAARYIHGRVYAKSPNRFINTKQGWITWIITVSIITLIGWLIAESIPFFDDLLSITSSLLISGFTFYFPAWMWFKLVKKGPCLSKENILLSIVNAIVFLIGMMVLFAGTYSSVQDILNHYDEGHVGKPFSCKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P245</accession>
    <name>A0A0B1P245_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 37s ribosomal protein rsm22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002181">
        <property type="protein sequence ID" value="KHJ32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P245"/>
    <dbReference type="STRING" id="52586.A0A0B1P245"/>
    <dbReference type="HOGENOM" id="CLU_043442_0_0_1"/>
    <dbReference type="OMA" id="KLNALGH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="318" mass="34974" checksum="85DB67EE7C59ABBB" modified="2015-03-04" version="1">MSTTVFPYLSKEKLKEAEKEATARELSWLLETLKEETFEALKSGIKECLTLLAPVNPGSTLVLSSLRSESIKGHVTRIGNQIVKGTFHLRLRTHAPLNLTISPVSSTSKNRGFYLPSLKTLSSLLEQSLSCLNSVQFSSAQIDQIPSIDSASTSIFSQLRLLYSLFQESISILKGSNSHLSPNTSLATSQYKAIEWNEEPSESVTFTPELPPTLALNISISDCSLLLTIRVLEPCAQAPTISSFFLTGIGVQRRLEHDEMDQEFLYRGKMVRVKEKCQVESSADPCLLSCAAKLQALERSTLGALDAIRTLTGSENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2A1</accession>
    <name>A0A0B1P2A1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pap2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002100">
        <property type="protein sequence ID" value="KHJ32413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2A1"/>
    <dbReference type="HOGENOM" id="CLU_645903_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="425" mass="48562" checksum="5191A40783B641D9" modified="2015-03-04" version="1">MEPVCRITNTPPGSLSAVSSERVNAQKIPRIYNETAVSPRTMQRSEKSVHEKVLAFNTMACQARNLERNPNDAALRRALLGREEAEREKRRSKEEARALRKALDEAKRRELIVGQRLETVMENFGRSRESFENAKISWDKEIRRARKESFKTQSAFLKAQEELKSCRMAVRAAKSDLDVEKARNNFYEQEAFQTRFELAQAQEKQANLQKQLSLAEQERDLLRKMVEKEELIRIASEGRIPLPNSPDDGEFAIPKKRCLSLEPITIDRSTTNEGELEELRMELDWEKQRARRAFDRIEFLETECKIKCYASGDVTHAVTQTNINPCTDQVTLSDANDDLNLEESLGNNAVVEIDPYGYSSQISNDRSYARTPSCDPPESIQEIYKTETPPVFSDTLEESGPGIIPSSLDFQVKIKGKIKIKLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2H7</accession>
    <name>A0A0B1P2H7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001763">
        <property type="protein sequence ID" value="KHJ32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2H7"/>
    <dbReference type="HOGENOM" id="CLU_052079_1_0_1"/>
    <dbReference type="OMA" id="LMLRNMP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="470" mass="52727" checksum="CFF1C67C93E54EAA" modified="2015-03-04" version="1">MSTQHEDSFLPSGAINTLGTYYDIPYYLSCPQTIDSNFHHHYPHITYETNSVMSPPKTRDASIEDVDISLMGDWSTFVQHLRNQFQGERAHLRADRDRMQEVIEGERELWERERQIWNKERKALRTRITDLEIKLLSVSDSNLNPGQVSSHENHKLPFTFLKNTDGSTITKIPQESGRDADGSPFYAPAPLNPTRTFDSETASNLRVDDLVVPRETAIRVTSKELTSLDFLPKMCSIHTVSEPQDVIGESIDISHIQPELDSVSIRVSAVSPTFAAKTLQPQGLLSRSNSQSKKGFCPIDKQKVRYEEKNGEENSGPAVFSPPDNNRLKLFAGHTPIRCGTNFDFPSELTTETRFQNCDIQNKVSSVFETQESDGHSPDNKDDGNEELSEPLGLVNASGQDDSFLARLTEKLAQEALKSENLESPSEFKPTQIDQEDSSSLSSSHEVEEAEGPILRMKPSLNFGRPFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2M2</accession>
    <name>A0A0B1P2M2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative transcription factor c2h2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001998">
        <property type="protein sequence ID" value="KHJ32538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2M2"/>
    <dbReference type="STRING" id="52586.A0A0B1P2M2"/>
    <dbReference type="HOGENOM" id="CLU_028753_0_0_1"/>
    <dbReference type="OMA" id="TWFSHLE"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="275"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="410" mass="47023" checksum="839635FE92C2A2FA" modified="2015-03-04" version="1">MSKRRLIQRSANSGVELSPVTNSRSESHVQASASSILEQYSPPFYPLSIDAKRKLEELNLHHDVMKYKKAIKDATNLITKSTYECNDRLWQRKQKLKAIEERIKTSGNIDEKLKLRHIVDKEYTSGLEKKVEEITFKAEKALRDLIDYGDELSIQQNLMHEVAQKTVSNTVSSHQSQLHSDSVANTLQQDESYSNDSIPKCIDLFRNVKKSYKSKYENMSLRQRYADHNDYKNFKGMIHDALNQGPNARPLEHPKYWFSGEKSQIFPSHQQSINEDDEIIMTSATTNLKCSFTLQYFEEPFSNRKCKHTYEKSAILDYLNTEGVVYSQPGQRGTRLGNKKITCPTPGCSVTLELEDFYLDERIRQQVVKAKRLEATGDSADNSDEDISQPIHSGRQVILDDEVIPCTQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2P8</accession>
    <name>A0A0B1P2P8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001702">
        <property type="protein sequence ID" value="KHJ32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2P8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2P8"/>
    <dbReference type="HOGENOM" id="CLU_040551_1_0_1"/>
    <dbReference type="OMA" id="RVDTGCI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801:SF0">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="270" mass="28876" checksum="B24D9A146C7B49E4" modified="2015-03-04" version="1">MSLDNFPLQQHFAPPPTSYTVAPDVPATNQGPVVTSTGITLNRPDDDVGTFNGGSYRISHRDTNSILTIQLAVLCPLTVKPGAMISMSSTLTLKGAIKFSVKKLIAGGEMSSSTYTGPGEILLAPPALGDISSISVSENQRWFVGRDAFLACTQDIVRDYKRQGIGKAMFSGEGLFVYNISGNGLLFISSFGAIIRKDLADGEKYLVDNGHLVAWNMKYTLERVSSGGIISNFSSGEGLVCKFTGPGTVFLQSRSPTEFGQWLSAYAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P315</accession>
    <name>A0A0B1P315_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001624">
        <property type="protein sequence ID" value="KHJ33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P315"/>
    <dbReference type="STRING" id="52586.A0A0B1P315"/>
    <dbReference type="HOGENOM" id="CLU_141774_1_0_1"/>
    <dbReference type="OMA" id="PEDENDW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="94" mass="10387" checksum="F16ED295680E0F91" modified="2015-03-04" version="1">MSSISAANTAQENANTSGSDNPGTQETKQVGATTLEEDDEFEDFPVENWGPEETEGANNNLNLWEESWDDDDASEDFSTQLKEELKKVQASKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P392</accession>
    <name>A0A0B1P392_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001594">
        <property type="protein sequence ID" value="KHJ33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P392"/>
    <dbReference type="HOGENOM" id="CLU_177979_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="95" mass="10466" checksum="708B886C017848E3" modified="2015-03-04" version="1">MNSWTPKAAGTAIGEPISLKKQVLKGNPPRGQNKEDRRIIIRLDLNHEARKSDPFQLRQTIQNLVPDKTLVSDVWKVPSGVAMLAPTPAKAATLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3C1</accession>
    <name>A0A0B1P3C1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative duf1237 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001579">
        <property type="protein sequence ID" value="KHJ33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3C1"/>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="OMA" id="WFAWCNS"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002059323" evidence="1">
        <location>
            <begin position="19"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="547" mass="61893" checksum="6D6484D0801582D3" modified="2015-03-04" version="1">MHHLTLKKLLLWITVWKATINTSQLPSESEYLISDTTDYLKSCPDYKIYAQFKHEPFSEGPMRLPFQRPSVQCRTFTSQLVEKIIKEVTERMVNKDLARLFENSFPNTLDTTVRWHVDGSIEKAHLDDISHQEEKWQGAQSFIVTGDINAEWLRDSANQLIQYLPLAKYDPGIYNLILGAINTQAEFVIESPYCNAFQPPRASNLRATSNGQRDVVHPAYEPSFVFECKYELDSLAHFLLLSNSFHNHTGSTEFITSRWLKALKSILTVIDQQSESTFDATSGEFKKNIYTFKRQTDQGTETLSLSGVGNPLNSGTGLVRSAFRPSDDATILGFLIPANAQMAVELQRTAKILHSTQNSFLAKVLEVRAQVIKDGVWNHGVVNHQKYGRVFAYEVDGYGSHIMMDDANVPSLLALPLLGFVEKNNVVYQNTRKMLLEKQGNPYYLTGQEFHGIGGPHVGLRHAWPMSLLVQAMTSDDDNEILNCLTMVLDSSPLGLIHEAINVNFNRIFTRPWFAWANSVFAQLIIDLASRKPHLLFNKEAASYIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3E5</accession>
    <name>A0A0B1P3E5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5704</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002546">
        <property type="protein sequence ID" value="KHJ31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3E5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3E5"/>
    <dbReference type="HOGENOM" id="CLU_010104_1_1_1"/>
    <dbReference type="OMA" id="QVYRDWW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="506"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="583" mass="65420" checksum="E70690A17221CDE1" modified="2015-03-04" version="1">MFRTQLNAFDEIVAKATDENLTSENWEYIMDVCDKVTGDENGAKDAVLSLIKRLAHRNANVQLYTLELANSLSQNCGLKLHRELASRAFTDALLRLAADRSTNQQVKAKIIERMQEWVEMFKDLDLGIMRDQYEVLKSRNPHLQPPSAPSKSRLTDLDRQKEEEELQIALRLSIQQEKPVDLKKPVAIESLSQSDQVKDNSATTIPVASGTTAATVSRVRALYDFQATDPDELNFSKGDIIAVLESVYKDWWKGLLKGRTGIFPLNYVEKLADPTPEELRREAQVEAEVFAEIKNVEKLLTLLSTASPDMNVQDNEEIGKLYYSTLAMRPKLIELIGKYSQKKDEFTQLNERFIKSCRDYESLLDASVAQSQVSYHQLGHPQGRDYVTHGGLSRQEIIRNYPQSPLQDQHYSQQSSTQNYITPRNGSAPFYIVPQLPQTQIDPQGPVYPLSHRDSSPVPPLGQVVKPSKPEHLQSKLSTPDHLPSSQPQLNYSIAGQQQISHELPAQTAQPTQPSQPLNLPPPPPSLTAGYPIIGQSSESLDSRKPLTNHGPYTAYQKPETPPDYSPSVPLGDPSDFYRSNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I1</accession>
    <name>A0A0B1P3I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative opa3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001550">
        <property type="protein sequence ID" value="KHJ33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I1"/>
    <dbReference type="STRING" id="52586.A0A0B1P3I1"/>
    <dbReference type="HOGENOM" id="CLU_074707_2_0_1"/>
    <dbReference type="OMA" id="IKAQAHD"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="203" mass="23600" checksum="D928E9B6D530F866" modified="2015-03-04" version="1">MSSLPLFKLASLFVRHISKYGGNWIKAQAQEHPKFREYAQRYGQKMHQINMRMAVTLLKNSTVDKRVKEKTEPSLNNKEQKHVEEVPSLKDTVKEKFHQKDVPSSVWKRKFRPLPEGKAVELFANVLGDSFVLLVAGTLISYEYMRSKARPDINSEKIADLYDKLEELSGRERDLENENNEVKIKLEALETTLIEVKNEKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I2</accession>
    <name>A0A0B1P3I2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002834">
        <property type="protein sequence ID" value="KHJ31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I2"/>
    <dbReference type="HOGENOM" id="CLU_1455421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="186" mass="20915" checksum="FEDA966D26B5DE8C" modified="2015-03-04" version="1">MYALLVAKYILVTILFLPGVLKILAFSYQDAFGRTNYGFKCGDKIYKKHEIFAAAKKYCDALTTRPEVTREHYEHNGYPALWMRLMMESLLSAPGGPFKLMPILRDGSLYPIDLPKESRVLKSLNGESHLIDPGPDRIVVSKSCNVITAFTDFGYFDSSVLRIETCDLLRNPVDSSLTPSNSHDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3J5</accession>
    <name>A0A0B1P3J5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g4894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001547">
        <property type="protein sequence ID" value="KHJ33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3J5"/>
    <dbReference type="STRING" id="52586.A0A0B1P3J5"/>
    <dbReference type="HOGENOM" id="CLU_001645_11_0_1"/>
    <dbReference type="OMA" id="WQQDVRV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="268"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="454"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="625" mass="70643" checksum="A13CD9627FDF8329" modified="2015-03-04" version="1">MAPNHKIREVIEQFPDSSLLLLDLRVFPQYSQSRIKGALNLCIPTTLLKRPSFNLQKLSDTFTNKEEKEKFLQWPKAKYIIMYDAASNQKKDSGPALHTLKKFIIEGWKGTSYILQDGFKEFAKTYPSLVDSRPFKEIQSSKINLSLGTNVTSVAPVVGGCLIPFTKNPANPFFSNIRQNQDLIGGVGQMDIKIPSQITTEYMKRLPKWLLGIAEKEDHGKRVSHKYLRIEQEELATMTKALSSKVSYRTPSVEPKSIRLAGIEKGSKNRYNNIWPYEHSRVKLLSRPEGACDYVNASHIKASRSNKRYIASQGPLPATFEDFWSVIWEQGVQVIVMLTAEKEGGQLKCHNYWSAQNYGHFLLETLSENRVPLEARPRNEVSRRRATIIDIEASRVATRSGQPVSEGPHVTIRKFALSHKGLPSSPVHEITQIHYCSWPDFGAPVNPCDLLGLVELSNLIQRTAAAPTQNPRIDEPEGEDTPPMLVHCSAGCGRTGTFCTIDSVIDILKRQRKEMSIKSVMKFPHSSFLNGHHSGKIKNTLPMIDDGWIWDGDMDLVEKTVEDFRSQRLSMVQNLRQFVLCYETVLEWVAQQVMRGQKPSPPVLKPVSTIAFEFNGSRDRCGSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3R7</accession>
    <name>A0A0B1P3R7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003029">
        <property type="protein sequence ID" value="KHJ31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3R7"/>
    <dbReference type="STRING" id="52586.A0A0B1P3R7"/>
    <dbReference type="HOGENOM" id="CLU_013566_0_0_1"/>
    <dbReference type="OMA" id="GGWLFND"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="906" mass="101291" checksum="83C9850B044848C3" modified="2015-03-04" version="1">MPPPFTLQKPYVISSLPQSISSFEDTYLASEVYGWTPGQKKRKRSELAVGINGEGVNLYDISATRLITSYAIPPQSNFTCPPSSSRIRISRSKVERRTYISYIGSKPRITLFHDTNDGSSQTHIKEVSKDIEGSPNPVVFIGCMVSEQNSNESDLKTKVILVKDNCEIQCYDSDNLQHEWTSPVSTLFRDSQSTPDDAKVEFAQITNLHCASQGILKNRKDILAIFSQNVLQVDFNIEILILITRSEKNPGRTLHIVSLPRQQAPTIEWTNQRSVISLLTHDLSHDIKVENSAQKVSFSLDVSAGILQQLENGILTVFNIMDSIPKKEYELNSLSANSLLKLSSTATMILTGNSISVYSPKSQSCLATVSLDLPGLANFKRQLDSCQNLSQASKLLSYFPKLGLVVAIVDSCLIGIQIEGQRDRYDRMRVCGLLIDSLGYLSGEQAQQGSDRRLSSKENKVKIQTLKYIQTVDYSNQQSWLKLLQPIEESFAKGDCTPEAFDQFMEPHLAPKTSKSAISIQFQEIEKRWAIYALSKIFTISQPDDSEPKLSITLPAFNTLKWLIQKGFMTKSNIESSLRYQTNQVHYISPGELTRNIVELDAEMELLRDLVLKTHLEADELLYIIRSLMESLGFCGTGKKLAEKNKICGHLKLPESKFREQMKIIDCEVKHDVELVESLLSPGSQIRSEALSLALSKLYVFPDEIIICALKKLYNPQTVVSLIYMLRMELVRGGWTASYLGLIDNGVNKNDTSTSDSFIILISTLMNCCIDAIGTGGWLSGEVQLMGGGLCETQKLIANLKAEVSLVLEGIEEMIYLKNILSEMVRYSDINHKELPINAKKDVSISLSISSGRYDTGLLPLGLKVEKQISTTKIGNGGEIIRRSKRDIGDRKSRKVGKYSRERINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3U4</accession>
    <name>A0A0B1P3U4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01002736">
        <property type="protein sequence ID" value="KHJ31616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3U4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3U4"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="OMA" id="HPIMREN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="163"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="387"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ31616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="607" mass="67557" checksum="33E8D059B175B3D1" modified="2015-03-04" version="1">MADPFNMENLSNSVPVTNPQDHGWGDKVPYDYDSYAKTSKELAEENEARANNGDEAAIHYAGAVGGVRVGEWHNNAAVYEWDDEYGDVGPEFPELERQLFGSEFHVKSGIDFQKLSTIKVVQEGEIRISPIFSFKDAGLHPVMLRNVELAGYEIPTPIQQYCLPAVFKGYDVVACAQTGSGKTAAFLIPTLSKLMGKAKKLCAPRPNPAKFQQGVTDPVRAEPLICIVVPSRELATQIFDEARRFCYRSMLRPCVVYGGGPIREQINQLQKGCDVLIGTPGRLVDFINRPHILTLKRLKYMIIDEADEIVGANWEDQMKTIMGGGDQEEGNINYLMFSATFPKQARQLAKEHLAMNHLRIRVGRAGSTHVNIKQEIIHVDPALKRTALQQYLLSMPPARTIIFVNSRRSADELDDFLFNSAFPCTSIHSDRTQREREDSIRAFRTGKTPILIATGVSARGLDIHNVMAVINFDLPSSNYGGIEEYCHRIGRTGRIGNTGVAMSFFTPRDEDLAPSLVKFLLETHHPIPDFLAHHIPEGFDASGEGNADLLDFGDDSDVEEEKNPDQNEASDNTFSQGAGADLWNADSSGDHQSKPTEEYKIEKENLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P432</accession>
    <name>A0A0B1P432_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002349">
        <property type="protein sequence ID" value="KHJ32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P432"/>
    <dbReference type="STRING" id="52586.A0A0B1P432"/>
    <dbReference type="HOGENOM" id="CLU_017633_0_3_1"/>
    <dbReference type="OMA" id="MATDYYA"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="533" mass="56967" checksum="618D7A883961123A" modified="2015-03-04" version="1">MKSRSSSLIKYVFVDNRNFAILCCRGRQNIRNEIFCHRKVRTLCYFANHSSRSLRKQLPLVLSFKRLFHASSNLSATKDPYIVLGVSKGASASEIKKAYYGLAKKYHPDTSKEANAKDKFAEAQSAYELLCDPQKKAAWDQFGAAAFDQGSGPGGPDMGGGPFGGGPFSGGSTSGFNASFNGAEFSGGINFDDLFRTFTGGGSFGRKQRGSRNPFQQDEILVGDSIEVRMSISFLEAAKGTSKKITINPLATCKTCSGSGLKSGSQRSKCKSCDGTGTRVHFVSGGFQMASTCQTCGGQGITIPKGGECRTCSGAGATRQRKSIDIDIPAGVEDGMRLRIDGEGDAPMTGTASNSNLRSLPGDLYVLVSVAPDSKFKRAGADVLYTAKIPLTTALLGGEIYVPTLSGEVKVKVATGTSTGDKINLTGYGMKKIDERRGSYGDLKVEFKVDIPKYLSANQRSIIEILADEFGDKTARRIMNVGKSTSPDSENGGSKKDGFLKSVWQKLTDQSCSSTKDSPDSDGKTNSFDKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4H1</accession>
    <name>A0A0B1P4H1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative origin recognition complex subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001589">
        <property type="protein sequence ID" value="KHJ33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4H1"/>
    <dbReference type="STRING" id="52586.A0A0B1P4H1"/>
    <dbReference type="HOGENOM" id="CLU_045412_0_0_1"/>
    <dbReference type="OMA" id="PCPPRIY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="375" mass="43001" checksum="2BA2ECF0A77C3CFF" modified="2015-03-04" version="1">MNRPIEQAIENLIPRHSNSIPSILIDLANSLFVQSRSKCILRAEEEVARAYACANLACERLKGKLDLPLIEPRPPIPPRAYEKLYAYISGKLDPKTPSRKRKQPTSSKTSTAISVTPSKSIQPWSMLREKPKTKAEPLNKSTVEKDCDISNEAKMEFLIPLWVLPTIRLLCKHMQTPKVAPHVLAGVESILCLPIPEKARSHSFNESELKLPAMIAAVWALVLAKISGREEQGRDNMEDIRPVLNFLGQIRKNEGLIKKIGQSEDSWRGWESIIESDVNAWIKEIEDGGWKELDWWRNIFEIAGHQSYEYSEDELGHDIPVEDKICSDGESDFKKNEVNNRYDYLSEDRKQEFAEWMSKMLLQINKMIDTRYCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4J5</accession>
    <name>A0A0B1P4J5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g4740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002563">
        <property type="protein sequence ID" value="KHJ31816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4J5"/>
    <dbReference type="STRING" id="52586.A0A0B1P4J5"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="14">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="13">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ31816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="396" mass="44493" checksum="5A42DF94EE36BDBE" modified="2015-03-04" version="1">MVEVSTKMDVEYTIKPEASTPVLDTSDWPLLLKNYSKLIVRTGHFTPIPHGCTPLKRDIKSYISSGVINLDKPSNPSSHEVVAWVKRMLRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLAVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDEQENMVTLHDVLDAQWMQDNTRDESYLRKVIAPLETLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRYEAGIEVHEEVVLMTTKGEAIALGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPMALEKKKMKADGKLDKYGRPNEATPSKWNEENPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q0</accession>
    <name>A0A0B1P4Q0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002489">
        <property type="protein sequence ID" value="KHJ31906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Q0"/>
    <dbReference type="HOGENOM" id="CLU_058864_0_0_1"/>
    <dbReference type="OMA" id="WGWNYTN"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079760" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="119"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="293" mass="31581" checksum="E12D1426A5A2A230" modified="2015-03-04" version="1">MKASVCLQLYWIFLLSTSNIVTAWPWPAILPPLNKILARQENNNNDDNQPAAPTPAQSSIQTSGKAQPMPTSAGNQKETSTISNGNAGTITGLPSETQSGDDSGSMTTTSGPTSFDARLPAGGVSMQTPAISLGQQYFKIGDYVTFGWNYTSLEATPTAVNVMATCAANKQLYTIQMNQTVANNTGLVVWDTGKYQATAVQNPLLTQTYTLIIYDSDSSISAVAQPGLLAVYNQYTFGMYSPQPYTPLGDFKCVTCNGALSEKERSVLSLVFGMSIITFLSFTYFVRDFGVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4U0</accession>
    <name>A0A0B1P4U0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative coatamer subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002174">
        <property type="protein sequence ID" value="KHJ32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4U0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4U0"/>
    <dbReference type="HOGENOM" id="CLU_007957_0_0_1"/>
    <dbReference type="OMA" id="VWYRWKL"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="492"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="804" mass="89268" checksum="79EA16B0A0236C22" modified="2015-03-04" version="1">MANYKSMSEFPDVENKLQAPSKKSLFERQRADAEAKRQREEAETKAVYEDFVKSFDDGDEDDGYTQSTSDGASFKGVSASSKRHYTSGQGPGIAIGFQSGWSAGPERGRISSGPGSLGPLPSSLTRKRPFDNMSSLQRAREKRNDREEKGLLAFDDYEVKDRVSKKPFTLDNDEDERRSEQEEDRAIPKPTIRLASMPPGTSPAVIKALIPPKLNIENLRILPPAGPSVSLERKSMSAIITLAKDTAANDIDAAVNALQNKYLGFGYYLNIQRHLSSAAFSSSESATLAGLGSSLASQPFGAKAVDVSNTNRGHAPPSHQGRYAPPSSYDTIGLGRTGPLLHVPVQAPQDIKEIKIIHKVIEALLTHGPEFEALLMSRPDVQREEKWAWLWDARSTGAAWYRWRLWEILTGIQTRRSQGKYIPLFEGSSAWKQPSKPLNYEYTTHLGEFVSDSEYNSSSDDNSADEAVRRQNYMGRASNDVAGLVTDEKLYLNPLEKAKLTHLLARLPTTTGTLRKGDVARVTAFAISHAGRGADEVVRMIILNVKKPFAYTSANPYRKKGKDKIAGSDEEEDSDTSAASLVGLYIISDILSSSSTSGVRHAWKYRQLFEAALKKGCVFEGLGRMEKKMNWGRLRAEKWKRSVENILRLWEGWCLFPQESQEFFASIFDKPPLTAKEIQENREKDIEEGIGEKGKGNKKWKSVEAKYLEGDANTLEKSENVDIDGALMDEDVDGEPMTDDEDLDGVPMDDEEELLDDHQENDSVKSALPESKENTKVESTPAPPPRPKRPRAVDMFADSDSDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Y6</accession>
    <name>A0A0B1P4Y6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chitin synthase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002627">
        <property type="protein sequence ID" value="KHJ31729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Y6"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Y6"/>
    <dbReference type="HOGENOM" id="CLU_008036_1_0_1"/>
    <dbReference type="OMA" id="FYEIGMY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="855" mass="96542" checksum="71A6D720E0BE02BB" modified="2015-03-04" version="1">MSTPKSSMTPPNKPQLTASYIPGRDGDLTVPEVISPLPQRIMPEFPSNMQEGLARLELETNQSRNSSTSSNGILLKSSNFELNHMRHPSLSKAFWTGFEYTNQAIYQSIIDNYWQPQRIGSITFNPFPRTQSLGASVPLSFEEKCELLEKVRQQILKSIDPEIQLAWAQDALLWVDIENEFATREISQNQPVRSITPKLERQLREDAVNIVKHLGEQGHPKAEFIKAYWAEFGKFGYPRDQRESFLCYTRAAEKGFARAHYRIGMQYENSGNLTKALEHYRRGVALQDSASHYRLGMMTLLGQHGTPVDCTRAVNLLRFAAETADENSPQGAYVYGMLLARELPNITVPEPYLPFNIREARKNIEKAAYLGFSKAQVKMGLAYELCQLDCEFDPALSLHYNALASKQGEAAADMAVSKWFLCGYEDLFEKDEKLAFIHAQRAASNELPMAEFAMGYFYEIGMYVKSDLRESERWYQKAAEHGNFDAVERITNIRENNVFSLKDHEQIAVKRIKSRYGSQRGDRPSRFKNPPLPLLNVKGEPTNTQSLINSYAVPLPVREDMKDTSKSYVHSNMSSEIGDQRNSYLGTIPAKVKDTTNLPTSPLISPSNSINRPISMAPYPIDDTDLTAYADDIHQGPDRPRSAFGIRPSLIHPKTESNFRDKTKRPISETRPSTSMGTTFTKEEYNHHPDFRSSSTYNQRITNRLHNIVPNEPGPHRLQKPVSSPNMNNIHSPHYSDDYYRRLPAQKNGSPAPRRDAALNYASHPDRKSTSNLPIQPNTNQQLRPNLQQNLSSQQASLPKKDLKIKTRPLPSPPTSSSTTSSLPKKTGPATFEEMGIPAANKEGECVSQFPTSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P537</accession>
    <name>A0A0B1P537_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g0328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002068">
        <property type="protein sequence ID" value="KHJ32460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P537"/>
    <dbReference type="STRING" id="52586.A0A0B1P537"/>
    <dbReference type="HOGENOM" id="CLU_020019_9_0_1"/>
    <dbReference type="OMA" id="FTSHHYY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="32265" checksum="E1FC7A3659CADE8D" modified="2015-03-04" version="1">MSRLGMMLGVYTSGISGANINPAVTFTNCIFRKQSWYKFPIYAVAQIAGAFCAAGVVYGNYKSAIDIFEGGQGVRTVPGLSDTATAGIFATYPQDFVSRTTEVFNEFIAAAILMFCIYMLQDKKNMGAGKLLPLALFFVVFGIGACFGWQTSFAINMARDFGPRLFTSCVGYGSDVWTAGDYYFWIPMVVSFLGCLFGGFLYDAFLYTGESPLNEPWFGLKRLTRLNRKEEYYCRCKCPVCSCISGIAKKIRTILPFRISHSSPRVSNVFVSTSLSPQHLFSRSPPRLAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-05-03" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5H5</accession>
    <name>A0A0B1P5H5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5H5"/>
    <dbReference type="HOGENOM" id="CLU_1897735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="134" mass="15517" checksum="516329DCDE26FC1E" modified="2015-03-04" version="1">MMNSLEHGSKRPFSARPPLSDTDIVSIFRKMHIVNALRMESVQKMESMRRRDAAKEKKVEEIPIQCVETMGSRALVRSPSVQMSPKELWNKKRLEREERAAKRARDREMGPCNLSVQDIQSNPWTQWTTPPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5N6</accession>
    <name>A0A0B1P5N6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001350">
        <property type="protein sequence ID" value="KHJ33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5N6"/>
    <dbReference type="HOGENOM" id="CLU_022625_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="500" mass="55719" checksum="D7E12CEFB8EB8BE3" modified="2015-03-04" version="1">MVCTGFISNIDSTVNNFQEGEEKETARKIQSQLLAAISQFAAADVYPASPSFRNPSKLKHSIEELKALTQKKTFQVAVPLVTPTTKPTLKKIPAPKHPLPKIPQVQGDSWVKLVRNGHKKSRATKESVELKESNARAQGSVTPSGLSIDKNQSSLNTEDKRLFIRLSQDHEWRNLSPAGIREVIVRKLSISPTCIKFIKPVRSGFALSPCNIQAREALFQSAIRLSSLNVKLESATNWTPVIIPTVPKTICTTEGRLEVTKSILGDEVERVTRTRPRALKLYGHSQHEAPHRTWMAFFTKAPRPGFRVFDESGIMRNYKRKHAGDRDYQAVARARAAEAEAKVKAAADTVSTLENTEDIMYYGQGNEIEKWADENRLLCLIIGEPTHRAGNTLDLAWTKISEITAWVDRDECMTSDHLPISGIVPSQFHPTAPPKKMLKVPNESLPYFAHVVSRWILPITYLNSTDDLEVFAEDLCRALADGIKAVGKRSSEGKGKSAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5Y3</accession>
    <name>A0A0B1P5Y3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002186">
        <property type="protein sequence ID" value="KHJ32306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5Y3"/>
    <dbReference type="STRING" id="52586.A0A0B1P5Y3"/>
    <dbReference type="HOGENOM" id="CLU_050252_2_0_1"/>
    <dbReference type="OMA" id="CAGGWVK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="347" mass="38852" checksum="41D59110AB4A3371" modified="2015-03-04" version="1">MGSSSRKKKENAKDFKKQKLRVGKTKAKPDNFTDTSFKSKSIVVNKQSLRISAPSQSSQFIHYLSLASNSKSVNQRKDALSFLESQISTSDVNYQIPLSTSTLLQKLLPLILDESASVRSQLLKVLGLLPKGDIVDRAENILLYVRAGMTHLSLEIRLDALLFLEWLLGVAEEEVVSCPGGWLKTLKCFMSLMGWAISSEAGKWTTGTKASFPNVGKAFPKQLQVFTKFLNTGLVESEYRLNLAAQKKSERINQNIIVFPMTDVQLQMIPEISNAYSYLNLFETPRDVDGEAYVDRKARQRVFQKRFLSVVQTGTQKARTEGGETGRAAANLEEILKKVMIDPNDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6J7</accession>
    <name>A0A0B1P6J7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc metalloproteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001172">
        <property type="protein sequence ID" value="KHJ33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6J7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6J7"/>
    <dbReference type="HOGENOM" id="CLU_056790_0_0_1"/>
    <dbReference type="OMA" id="GMQKHPF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="135"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="354" mass="40419" checksum="C921FDAC832D4EDA" modified="2015-03-04" version="1">MTQENPKFNLKPPAMTTIDDDSSVSISIFYHGTPHNFSLPLNATILDLSTEILEVLHIPTLNQKFLISKIGLLKPPFKDPELPITSISKQKITLMGSTKNDISSVSLASEQATKREYRQGRPKQVTAYKTHDWKREQEESKYTFCKLQPLSNLPNPSRSLRLLQRLKDDAGIKAVMRKHKFTVPLLTEMDPTIHTQLNHEGTFRTLGLNRNQGEIIELRLRTDAYDGYRDYKTIRKTLCHELTHNVYGPHNQDFWDLCKKIEKEVEASDWRSGGNVVGGRETYDPSREVNANDDCERWTGGEFILGEDPSKKKSPSISDGDSSRREIMAKAAEERMKRLDKRLCNGNCDSTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6M8</accession>
    <name>A0A0B1P6M8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002208">
        <property type="protein sequence ID" value="KHJ32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6M8"/>
    <dbReference type="HOGENOM" id="CLU_1161882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29504" checksum="EDC10F2EF05C6B47" modified="2015-03-04" version="1">MELYLKYRRVQHAGITRNSPVQKTIGKTCRIISREVRENVNYSSLSKEKDKEEWSRICNGEESIKRQKELGKMAAFREWESSWPHKHRNVNLRHRAAADPEVWNAASYYIDKKTGRQKMSLKGTPSNLHRHLKRAQSSVAMQIRSEHIGLKSYLYRRKVPGVNNPSCLCGYPSENVKHAVMACPLKVRGRTEVWRKAKNRSFEAMISNPEDLGRITQWILDQGWFDQFRLAGVVEKVIQERGKIQKSNEGNLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P772</accession>
    <name>A0A0B1P772_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g4743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001585">
        <property type="protein sequence ID" value="KHJ33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P772"/>
    <dbReference type="STRING" id="52586.A0A0B1P772"/>
    <dbReference type="HOGENOM" id="CLU_098404_2_0_1"/>
    <dbReference type="OMA" id="IPMNFFM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="182" mass="20496" checksum="9ABA9CDBC4D22E29" modified="2015-03-04" version="1">MGSTSQVPQWVIDLQHPPTPKHATSLIPDPTNFTVHSSKKSQNTSSNMARPLPTAAEMDVLKLKKAWEVALAPVKQLPMTAFMMYMSGNTMQIFSIMMVVMAFKTPIMGLLAINQAFGKFESDTIKSQLVMVKGVYVLMQILALGLGVWKVDRMGLLPTTRSDWVYQLSLYEHQYCYTDLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7H4</accession>
    <name>A0A0B1P7H4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000771">
        <property type="protein sequence ID" value="KHJ34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7H4"/>
    <dbReference type="HOGENOM" id="CLU_2074897_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="118" mass="13245" checksum="1801715B8DC1510B" modified="2015-03-04" version="1">MAYYDTVSLIVGNSEGIQKEIYSRLLSWDLRTPDLESKQKSRLQNIFFSGVSIVDAIKVCKGAAGFEQSRNCVPQLWSLDLASSVGMRRTTEIGDLKTFLIFNIPGRGLKSELGNRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Z9</accession>
    <name>A0A0B1P7Z9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g5881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001401">
        <property type="protein sequence ID" value="KHJ33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Z9"/>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="342"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116472" checksum="414F895D77DCAE56" modified="2015-03-04" version="1">MDIQIQNAVNVAWDPSSSQDNKMQALEFLNQLRSFPSGRQACVTLFIKVPPCSDVVRLVCLDVINNAIQSQQLDFQSFEQMKGNLLNYITLVYGSCSQEIADPAHIQNKLTQTLTLLFMKSYKHGWESFFDYFLTLTCFQNDGVRNNIKGTMLYLRILGSIHDEIGDVHISRSNEDNRCNSELKDAMRARDVPKIVSSWQEILTYWQNQDDVVETCLKVIGKWVSWIDISLIMNQDLLNTLFQFVGQNNQQKKDGKVRDIAIGTFTEIVAKKMKPSDKIALILFLNLGEVISQLIRSPPLHELRTTSSYDTDLAETVAKLINNVISDVVKILDEAQNQSQTEVQMQAQQLIQSFLPLLLRFLSDEYDEICSTVIPSLTEFLTFLRKSKPLPVMYTAMLQPILKIVIQKMRYDDTSSWGKEDEQTDEAEFQELRKRLQVLQKGVAAVDESLCIEVVSNVVGNTFQMFEQQHGQMDWRDLDLALHEMNIFGEFALSNCSFYIKNQPASVAAERLAVLISKMIDAGIASYTHPAIKLQYMEICVRYYSFFENQTTYIPIVLEQFVQFVHHSHIRVRTRAWYLFSRFVKHLQAHIGNMTEKVIESISDLLLIRAELPNRNIADDISSEESDVSLDANFNAQLNLFESIGSISSATEIPVENQVLYVRTIIEPLFSEIERNIEPSKSGNLQSILQVHHVMMALGYLAHGFSAWVPKNATALLAPSKVVREEFARVAEVILISLEALKSSFDIRTAARACFSRLMGVLGTDMLTLIPRWIDGLLSESSSKDEVAMSLRLLDQVVFSFKKDIYGVLDSLITPLLQKVFAGLAEPISGTDDEIQLAELRREYLTFIQVILNNELGIVLISESNQGIFEHLIHSISNLARTLTNETGSLIASRLAFSVITLMAHSWGGPDIIRRKDSVLNPKLSIQSNLPGFDRFLIEKFHPICWEVLRLPTFRPTFDAQCKQILNEIAGLEYTIYTKTGDLFLHHLQQDFFPLIGVDGSDFIQILKTSPDRKCLAKCLQDYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P860</accession>
    <name>A0A0B1P860_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g6134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P860"/>
    <dbReference type="SMR" id="A0A0B1P860"/>
    <dbReference type="STRING" id="52586.A0A0B1P860"/>
    <dbReference type="HOGENOM" id="CLU_000288_52_3_1"/>
    <dbReference type="OMA" id="QWAEYIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="102"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="304"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="566"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="675" mass="75696" checksum="8F6EA75454F84F53" modified="2015-03-04" version="1">MISTEMDLLKQATHSIIFSGSEDVPKDSESGNQTPRSGIPTPQPDPVDRRLPGIEHSYFGQSISVTPARTLSNRTCMSDATIGSDSDDRQEKFTPSDGSKNEPTPLQTPVTTASAPPARGRLIVKISKARGLRKSRHPYVLAVFQRSELFSNGPISEDEDQYKNHMESLEVGGIPVVRSSSDSKPMVIPMKSRQSSNTSTIDHPDVTFRKKNTINPHWETKAIFDVVGSDPSIHLTIYDRGLAADEFLGHTEFQANLTDIDSPPFKGWLQLQGKNDKDCANMGEIYVEVKFQPTRKRHYGPEDFQFLKLIGKGTFGQVYQVRKKDTGRIYAMKVLQKKVIVQKKEVAHTVGERNILVRTAMAESQFIVGLKFSFQTPSDLYLVTDYMSGGELFWHLQREGRFCEERAKFYIAELILALQHLHKHDIVYRDLKPENILLDANGHIALCDFGLSKANLTKNETTNTFCGTTEYLAPEVLLDETGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDTLTTEGRNFVKGLLNRNPKHRLGAIDDAEELKRHPFFADIDWDLLAAKKITPLFKPQLDSETDTSNFDPEFTNALNGDGPLNDRAAALAAGIATSTPLSPGMQANFKGFTFVDESSMDENMAGIGSRNDWESGDDYDIQCDEDFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P884</accession>
    <name>A0A0B1P884_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001783">
        <property type="protein sequence ID" value="KHJ32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P884"/>
    <dbReference type="STRING" id="52586.A0A0B1P884"/>
    <dbReference type="HOGENOM" id="CLU_019692_4_1_1"/>
    <dbReference type="OMA" id="HVNDYCS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="546" mass="61246" checksum="1F361307D104B7BC" modified="2015-03-04" version="1">MTRRIVRTILQFTTIFIFIFIIVYFLDSQFRVLPTSIHNHLPTHHPGLVITDITVTTCSSISLFTGCKLIPAHWHRLDKDLYLGSGWISKAYVHVQGKKEEDLLPEDKVVFDVTVGRLDPTSTREKNEDDIKWESRPMGIWLKRSAKRHASDSFQAVTAVDVLFGPDAVDPRNKWQLVGTAILLNSGGENQQARLTIRRGAKREEPRPILQINEHGKFKIMQVSDLHLSTGTGKCRDPQPPETAQGCEADPRTLDFMERLLDADKPDIVILSGDQINGETAPDAQSAIFKYAAPLIERKIPFATIFGNHDDEGSLSRETQMSLIESLPYSLSVIGPPNIDGVGNYYVEVQAHGSKHSALTIYLLDTHGYSPDERNFKGYDWLKKNQIDWFRATANELKRNHEGYSHIHMDLAFIHIPLPEFRNESLPRKGAWREGVTAPLYNSGFRDALIEEGVLLVGCGHDHANEYCALSSNDLGNPALWMCYAGGAGFGGYGGYGGYQRRIRFYELDVNEARITTWKKVESGSEAAGKIDEQVIVDGGKMKPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C5</accession>
    <name>A0A0B1P8C5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative 30s ribosomal subunit s4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C5"/>
    <dbReference type="STRING" id="52586.A0A0B1P8C5"/>
    <dbReference type="HOGENOM" id="CLU_026386_1_0_1"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="508" mass="59904" checksum="82B05479C6B0AD28" modified="2015-03-04" version="1">MARKPRFHGLKKPKIRSSWNKYNLYNLSRLKIPNTAFMTYFQQKWSAKSLARAYHGDKIIREKQWERMFSPNMNAVVPMDHKYLAEFDGSELAEGRGSGKDVDPKAQKESAMITKKKIPYMNMTFAPLERRLDMAIFRSLFASSHKQARQMVVHGHVKVNGQKMEHPGYLLNPGDMYQVEPDVVQHATGDRLNKREKMLRKLHVRRSKITKRRSIENFDKYMKKNVLVAPKVGTYNDEPKKRKYWLKKFQNLWTYIKTTYHTYEPTRRIKYRFLQKSIEKVVLNWYELPWKKLDSAMRKVALEYRGARTHFPKETPERQEWLKRRLAIDRKNHAEMCRRMRERRALKPQNTKKKKLTAISVAPSTPEIDSTNTPSPLPPLTAKIPKIDPRLATRPGINIYMGQIEKIPMIKKQPYEGYEYKPSAKLRKRDRNAGVPPGGGSKTYPLPWRPKPFMSAFAFIPRYLEVRQNICAGVYLRHPVARPGLSEVPSPFPIETMQLAYNWYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8I8</accession>
    <name>A0A0B1P8I8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001696">
        <property type="protein sequence ID" value="KHJ32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8I8"/>
    <dbReference type="STRING" id="52586.A0A0B1P8I8"/>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008079">
        <property type="term" value="F:translation termination factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="482"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="727"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122832" checksum="61F68AE56F0089DB" modified="2015-03-04" version="1">MPHHIPSPCIMPVMISKADGPLPTQNDISGILDNIFTLDSDSSIAAAYSLCDLLLNSIGFKGLTSYGIITEIKRAAVDKKATSRREGAQNLLGAIFERLIPKQRICEVILLNLDGGMVSYGLDALADKTPVIRSAAQYGIDELFKSLSPEALVCGLLPTLSSYLEKRTGKWQGTVAAYKLLQKMADKAKMELATTKEEANEKDILRKALGSKLGGLIPIVEAGMHDMKVDVEKQALATMTALTALLSNDDVAPRIPLLIATMKNPSTSTLQKAIHALSQTTFVAEVTSPVLALLTPLLERSLNTPSTTQEVLRQTVVVVENLTRLVHDPVEARIFLPKLKPGIRGVIDRASLPEVRQLAQSALTVIDKAMGDYNGATAAPGIISHVTPHEVSLILETHVKKTSSIVDTDAFKLAKPYICNMVSEDINHRETHRISGCIAPYLQNITKDIESAEKIGIAVQKFYIEEDLRKYGQPMKEDDGEIEIVNADFSLAYGGMLLLSHTNLRLLKGHRYGLCGRNGAGKSTLLRSIATGKLEGFPPPDILKTCFVEHNQGEDADISILEFVAKDPEIGEAGRARISEVLSEVGFTSGPSGRQSEKVGSLSGGWKMKLALARAMLMKADVLLLDEPTNHLDVANVKWLQEYLKSHSEITSLIVSHDSGFLDEVCTDIYHYEPGKKLACYKGNLAAFVKQKPEAKSYYTLSASQVQFKFPSPGILSGVKSQTRSILRMTNCSYTYPGASKPSLHNVSCQLSLSSRTAIIGGNGAGKSTLIKLLTGETVPTSGRVEKHPNLRIGYIKQHALEHVEMHLEKTPNQYLQWRYANGDDREVHMKQTRILSDADKAQMEKWIDIDGKGGKQIEALMGRQKWKKSFQYEVKWKGLLPKYNSQISRETLIELGFDKLVQEFDDHEASREGLGFRELLPKVISKHFQDLGLDPEIADHNEIGGLSGGQKVKVVLAGAMWNNPHLLVLDEPTNFLDRDSLGGLAVAIRDYKGGVIMISHNEEFVGALCPEQWHVADGRVTHKGHLAINSDRFEETSRPGSGLNSSVASSTINSENASAVNSCAEENGDMSFRSRKKKKMTKKELKEREVRRRLRHIEWLSSPKGTPHPPDTDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J3</accession>
    <name>A0A0B1P9J3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative telomerase-binding protein est1a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001524">
        <property type="protein sequence ID" value="KHJ33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J3"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J3"/>
    <dbReference type="HOGENOM" id="CLU_010014_2_1_1"/>
    <dbReference type="OMA" id="MWRYGVH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="425"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="765" mass="87754" checksum="01BE1EDDC05A938D" modified="2015-03-04" version="1">MLSDRWIRHQRKQNRPRVEQQLQGPFKEEVQSDFCKSSLKACSIDKAKKEPPKSLRNLNEGQFSASISPSVSGKRHSPTRTVFITSDSKLNRSVDKTNMMTEKNTRDERRFKRAARGDGISSSGSTSPCQNIDAPSSPKLKTHRTSNVRIDPLVQRRSNGNTKSIWVEGDVAPTRTSVDQSNIASVAIARKRNQFLQNTARPSTHSTPLKSGLQLLNSAGTTNIEGTNETTTLSAERRKLSMVLQPGIKPLTQEQLIARVKSIYVELVAIETKCISFHSKPDSVVRALTQQTDPNSARNLNHDGIQKLIALHRKLLYHYHDFFLATQHPLASIPVRRLASKYAMPARLWRHGIHSFLELLRHLLPASFDYMLSFIYLSYSTIALLFETVSVFEDTWIECLGDLSRYRMAIEEDNSRDREIWTNVARDWYIMASNNSPTTGRLYHHMAILARPNAIEQLFYYSKSLCSPKPFFSARESILTLFEPILEDNLELIDDKHLTLDILFVKAHGILFTNSLMDKFTLIVQMITHQLHHHVKMMKFFRSQSYHMAIINCVALLEYGAKSNNLLKLILKNEESNVIDMEQNETELQNELGSFARALNLSNSFLASIIGVTCLCESDTLPYIHVTLVFIFHIAMYPKTIAYIKNGFPWESLATKLNGFFLSNYNLTRIEDDEFPNPEDDKIRPLPEDYAMRGFVWATEYFPNNWFSNDKIEEEEKYREHPSLDAERRERILWLAHKISKLDTPLIYRGKVFSALMNDSRESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Y7</accession>
    <name>A0A0B1P9Y7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mrna binding post-transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000369">
        <property type="protein sequence ID" value="KHJ35507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Y7"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Y7"/>
    <dbReference type="HOGENOM" id="CLU_016304_6_2_1"/>
    <dbReference type="OMA" id="VRIFKMQ"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="161"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="294"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="404" mass="43778" checksum="CCC4668FC94868EE" modified="2015-03-04" version="1">MAYPYDQNQQNHFSQDVNGGIHQETAAQGMPPQQQSIQQGLPENGSPAAFTQQGVVDGSGGSVTGDAKTTLWMGELEPWIDENFIRSVWFGMGETVNVKMIRDKFSGNAGYCFIDFSSPAAAAKALSLNGSMIPNTSRPFKLNWASGGGLADRRDDRGPEFSIFVGDLGPEVNEYVLVSLFQARFPSCKSAKIMTDPISGMSRGYGFVRFASEQDQQRALNEMQGVYCGNRPMRISTATPKNKSGVPGVPINMPMAPQNGIGTTPGMYGMGAPPPMGYYGAPQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGTPYRPAPPPPQYNAIGMSPAQHFAQYQQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA04</accession>
    <name>A0A0B1PA04_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001250">
        <property type="protein sequence ID" value="KHJ33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA04"/>
    <dbReference type="STRING" id="52586.A0A0B1PA04"/>
    <dbReference type="HOGENOM" id="CLU_008554_2_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070159">
        <property type="term" value="P:mitochondrial threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="445" mass="50654" checksum="04A2A3A2E581D1AE" modified="2015-03-04" version="1">MYKSSLWKTSGHWENYADDMYAVIQRSDPESQQNEQKDQDEEYGLKPMNCPGHCLIFASKARSYRDLPLRYADFSPLHRNEGTGTLSGLTRVRCFHQDDGHIFCRPSQIKEEIRKSLEFVKLTYSVLGLEPYRLVLSTRPQEKYIGSIEEWKYAEAALVESLNDCGSNWTIDEGGGAFYGPKIDIILQDTGGKDHQTATIQLDFQLPKRFELQYQAPAPAQEQNGQLCNDRSLLNVEGPVTPILIHRAVLGSVERIMALLIEKYNGIWPFWLNPRQIAIITVNNSPEVLEFARQAKNIIQGFGTSNSEQERYLDKRIKTRGININIKVFDKTTSVSHKIAVAKSQRYGIIVLVGPKDIQSQTLSVDFSGIPNRSQYTDDILKKIPLKAKSHTVGELIKWEEIDCSAEHIDPSKQETKFSATKQSHIALPPEWLRSIVHELIKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA68</accession>
    <name>A0A0B1PA68_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000500">
        <property type="protein sequence ID" value="KHJ35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA68"/>
    <dbReference type="STRING" id="52586.A0A0B1PA68"/>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="OMA" id="PFQANYG"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="116"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="301" mass="32022" checksum="804996B256AFD29B" modified="2015-03-04" version="1">MAQFFQPASNASPYANPTSNSQNLQFYSSSYAPGQIPSQPSPRTTFGAYGHSASPGFGYRGNYGAPPGVSGRMGEQGGLRTGWLAAFGTEGYEGEPALLEELGVNFDHIWSKTLAVLNPLAHIDQHLMDDSDLAGPILFFFLFGTFLLFSGKVHFGFIYGLALLGSVSLHIILSLMSPPPLDALHAARSEPPSPHSSSNLTSCLTFPRSLSVLGYCLLPLVFVSLVGIILPLQGMVGYILTTTAIIWCTYSSSGIFCAVGRMRGMRGLVAYPLALFYVGFGVMGVFSRGGNVKISNGKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC4</accession>
    <name>A0A0B1PAC4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g4525</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01001334">
        <property type="protein sequence ID" value="KHJ33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAC4"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019280">
        <property type="term" value="P:L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="435"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="662"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="736"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
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        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="765" mass="86608" checksum="FFC9B3426BE02E2B" modified="2015-03-04" version="1">MVQSSILGFPRMGVNRDLKKATEAYWGGKISQDDLLAEAKRLRLVHWKIQKDAGVDIIPSNDFALYDQVLHQIQDFGATPPRYTNHGLNRVDEYFAMGRGHQKDGIDVPSLEMVKWFDSNYHYVKPTFQDNQEFKLYSNPKAVEDFLEAKAAGIVTRPVIVGPISFLHLGKADRDQSVVPIDLIDKVFLVYQDLLMKLKAVGAQNVQIDEPILVQDLPEKVKSSFKPIYEKFFSLGDQIPNLVLTTYFGDIVHNLDALPQNLYALHIDLVRNPEQLGPVASTIGPKTILSAGVVDGRNIWKTNFQKAIEIVEASIQRLGKDRVIVATSSSLLHTPHTLASEKKLDPEIADWFSFATEKASEVVVIAKALTDGPASVREKLDANAKSIQSRLTSPRTNNPQVKERQSKVVPEMYNRKSEFPIRIKAQQKSLNLPLFPTTTIGSFPQTSEIRVQRNKFTRGEITSEEYEKFIESEIEKTVKIQEELDLDVLVHGEPERNDMVQYFGERLEGYAFTTHGWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAVSISKKPMKGMLTGPITCLRWSFTRDDVHQSMQAEQLALALRDEVIDLEAAGVYVIQVDEPALREGLPLRAGKEREAYLKWAVESFRLSVSGVQDSTQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLKVFVDEAYPRHIGPGVYDIHSPRVPSEHEIRERIQEMLQFLRPDQLWIDPDCGLKTRKWPETKAALVNMVNAAKYFRAKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAE2</accession>
    <name>A0A0B1PAE2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01001307">
        <property type="protein sequence ID" value="KHJ33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAE2"/>
    <dbReference type="STRING" id="52586.A0A0B1PAE2"/>
    <dbReference type="HOGENOM" id="CLU_051214_1_1_1"/>
    <dbReference type="OMA" id="MERRFDM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="87"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="317" mass="36201" checksum="92F43169BF366C31" modified="2015-03-04" version="1">MSVLGSIRIYLKKLRGPVLCRMWKVPWYRISQILNQRNKKFWCFLIALSLGTLIVFGIGLGALLAQRENLRSSLSNGIFWRPTVGTRWQIVLNSTLTNQSFDAPVYDIDLFLNNARIISSLHANNRKVICYFSAGSYEPFRPDSDRFHTRDKGLQLDGWPDEFWLNTNSRNVRKIMKNRLRRAARIGCDGVDPDNIDAFDNLNGLGLTTNHAIDYLRFLATEAHRLGLAIGLKNAGAIVTDVLDIMEWELNEQCLQFGECGKFQPFVDVGKPVFHIEYPEIIPNFSMASSDYCRDSRAQGFSTILKNIQLDDWALNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAI0</accession>
    <name>A0A0B1PAI0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative blue light regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000294">
        <property type="protein sequence ID" value="KHJ35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAI0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAI0"/>
    <dbReference type="HOGENOM" id="CLU_024414_0_0_1"/>
    <dbReference type="OMA" id="HTDTIEM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="444"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="506" mass="57412" checksum="EC9AD0D26FF4D150" modified="2015-03-04" version="1">MTPPWLIKIDLDVNSSVYYGEEMEVPDSQIFLQKAYSDKLWRGNGSFIPQLLHADLFEGLESMPSNLENIFDDCFPREYLVPQTIARPSTLPPIEGDKSDMQTPAQPNPNESPIIGVGDGPLPADFGMPSVYDRNSSTPLDFTKRRNWSQRIIEEIRDFLHVLTPDGRMIYLSPSVEPITGYAKAELKGKFIVDFVHPDDKTMFLQEFNESIANESTLRCFYRFLKKDQTYIIFEAHGHPHFRVELGYDGSSSYSNTCRGYFMMARPYLTKNSTLLDSFLEHKIENLRLSKRIEELRKEEELEEEAQQKWLKQADQFNSRLNSPVGSNNTSQSQMSLGAKHNDCDFMSMPPPARPVGAPLTKKALEQSNAGLGPDSIKDKMERYEGTARIESIEMLTGLRYKEGERSYGISTGAQSPLLIKGDAGISLPQESETRGEKKRKNKIEDDYVCTDCGTLDSPEWRKGPSGPKTLCNACGLRWAKKEKKKPSYVVTDRTAQKINTEPIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAQ1</accession>
    <name>A0A0B1PAQ1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001081">
        <property type="protein sequence ID" value="KHJ34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PAQ1"/>
    <dbReference type="ESTHER" id="uncne-a0a0b1paq1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_7_1"/>
    <dbReference type="OMA" id="EWSKGGF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005109765" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="37"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="559" mass="62273" checksum="F426E00CE0EAD7C6" modified="2015-03-04" version="1">MLNVVVLLTTFIICSSLTFATYFEPVNHVQVNTDNIIDLGYSQYQGVKNPVAAVKYWLGIRFAAAPLADLRWRAPVDPVVNYTLQDASIPPNVCIGIGEYGTSVQSEDCLFLNIFTPANATPSSRLPVWFFIPGGGYSVNSDPNYNATEIIKQSGGKIIVVETSFRVSAFGFLASEKIRQDGSLNVGILDQRKALKWVQKYITKFGGDPGRVVIHGDSAGAGSVAMHLIAYNGRNDSLFSGAILESVFFPTQRKVIDYEFQYNNFVSLSNCSSSNDTLACLRNTPLSILKVANSNPAPFPNATAPSRFPYAPCVDGDLITDYPAKLFLDGNFLQVPIMIGGDTDEGNDFVNNASTSNEMKQYMHNQFPKLSEKNLEKMEQLYPLMPPLPLHAPYFPSVALAYGEATFTCPGLLISSAFFKYSSDLGDSLVPIFHYHYNVQDYDLIAVGKGVPHVFELQALFNTYDPKTSSYNTYNAPIVPQVRNYWINFVMRNDPNHIINNTSEGQTKIIWTPWGDMSENLNIEQRLLIQTNATQMENVSLKELERCQFWKDVIDETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAT0</accession>
    <name>A0A0B1PAT0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dnl zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000432">
        <property type="protein sequence ID" value="KHJ35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAT0"/>
    <dbReference type="STRING" id="52586.A0A0B1PAT0"/>
    <dbReference type="HOGENOM" id="CLU_093902_6_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="179" mass="20380" checksum="B482E9B4640B32CF" modified="2015-03-04" version="1">MISLGRSSLTAKRLYQFLNVRRGAELKPFIFHIFGNYSQTSILFTLRSKFHSIPKNNTAKEQSIHADFDHQVSSKANGNEPIETPRDEYELTFTCQPCGARSTHRISKQGYHHGSVLVSCPNCKNRHVISDQLKIFGDKITNIEDLLREQGHYVQKGTLSEDGAFELWADGNRNKRTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAY3</accession>
    <name>A0A0B1PAY3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mfs general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000236">
        <property type="protein sequence ID" value="KHJ35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAY3"/>
    <dbReference type="STRING" id="52586.A0A0B1PAY3"/>
    <dbReference type="HOGENOM" id="CLU_018303_1_1_1"/>
    <dbReference type="OMA" id="CAWVGFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005364">
        <property type="term" value="F:maltose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106081">
        <property type="term" value="P:maltose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106082">
        <property type="term" value="P:sucrose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004896">
        <property type="entry name" value="PucC-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03209">
        <property type="entry name" value="PUCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="550" mass="60665" checksum="8723F18037E2A7CB" modified="2015-03-04" version="1">MTEEESPLLSTNSSDPEALTPGRASSQNDIYDQYQETKSLWYMVLLTISIGGLQLAWSVELSNGTPYLISLGLSKSSMALVWIAGPLSGTLVQPYVGMLSDKCRAPWGKRTPFIIFGSVATIISLLTLAWVKEISLKFLGLFGVDSESQISKDSVILVAVSMVYVLDFSINTVQAGIRAFILDCAPSHQQETANAMASRVIGIGNILGYVAGYVNLRHYFWFFGDSQFKILCVIASITLATTVLLSLSTIRERDPSKEVQLISDQAGILFFLRTLFLSIKRLPPLTRKVCEIQFFAWIGMFPQLFYSSSYIADIYVQPYLRSDPHMSKSELDRLYEKATRVGTFALLIYAITSLATNVFLPFFIAPTHDTSTSKLFIPGFTLRKAWMLTQLIFAACMFSTIFVKTISAATVLIGIVGICWALSLWAPYAIISAEVSKRDLLFRNSDASSCNTNLTNKTAESSQDKAGVILGIHNMSIAAPQIIATVASSIIFKFLQKPRGTPGDISFSVVLAFGGFSTLIAALLTSRMKDKTTFINEESCNKEPRKDRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB02</accession>
    <name>A0A0B1PB02_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001228">
        <property type="protein sequence ID" value="KHJ33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB02"/>
    <dbReference type="STRING" id="52586.A0A0B1PB02"/>
    <dbReference type="HOGENOM" id="CLU_032087_4_1_1"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="78"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="374"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="439" mass="49577" checksum="615CBEC4551867F1" modified="2015-03-04" version="1">MSFRLLGKGVVKKMKEGIVEGVFAVNKPSGISSAQVIRDLQKHFNPSKLFAPWIESERISRDQESKSQKRRRREKKIQVKIGHGGTLDPLATGILITGIGRGTKSLHDFLMCKKEYEAIVLFGTSTDTYDRVGKVLKRAPYKHITKEVVEKALENFRGKYMQLPPLFSALKMNGKPLYEYAREGKEIPREIEKRPVEVHELELVEWMEGGTHTHEPPTEEAGYLELNVAKQIWKQTGVKQQNEPFIDKSETIKLDKGVDFKGDGEIEQPENTPVVESDVALKQKKSGDNLIEIGSPKIYSQKRKRSNSESGSPHNEKKDTATIYNKGIEQSDDVPQTPVNFSKINHESSSSCEDNGKPPAARLRMTVTSGFYVRSLCHDLGVAVQSAALMAELKRTRQGDYKIGEDTLEYADLEKGEEIWGPKVERWLSKWQEKHCAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBD5</accession>
    <name>A0A0B1PBD5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000772">
        <property type="protein sequence ID" value="KHJ34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBD5"/>
    <dbReference type="HOGENOM" id="CLU_1688035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="156" mass="17781" checksum="17897DB14C681B71" modified="2015-03-04" version="1">MKRKDETNDEYNMRLERYNDRNDAAHSAILNGVSDDLQELACSFDEELESARVAMRLLKDKYDYETTTSTIQLFKEFSELKMAEGDLISHHITQFETAYSLFTLVVQAPLVLKQLLNGTSSRLNKLKLCTCSFLSLPLIITSLIILLPKKLLGSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN2</accession>
    <name>A0A0B1PBN2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000942">
        <property type="protein sequence ID" value="KHJ34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN2"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN2"/>
    <dbReference type="HOGENOM" id="CLU_061028_0_0_1"/>
    <dbReference type="OMA" id="NDESQFF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="383" mass="44378" checksum="8B390AB5833C9B61" modified="2015-03-04" version="1">METLGEIDQHIWTPPEIQYQLARGHRNSRLIVLYNEMHVNRKTKDPEAETYETKSTLVYKNIDAKQIPFKQILPSQVRSSQPYSQYAPENSSSDPNPQIMKNFSNYKNSGGRAITNLRKIYTQELKFCGADDSLSLKLEIFYDLCAENGITEDLYRIALPIMLSGQAHTYYYSTIAKLNLDFNGAVQMLQNQYETEQRQQKDFSEWSTITLANVLTQNSNKSLQEFFELMLENQTLRVKVINACRSIPECSLACYSPAPSLEGVCYQLRSSIATAMELSGKSFFNQNTQPSGQFVGQNDESQFFTYRCYHGVNKYNRTSKHPNDKNRFSKKCFVCKQPGCWSTKHSKSERNIAYDNFRKRIQQRGRRPDESMISQYVFEYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBN3</accession>
    <name>A0A0B1PBN3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g0515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000722">
        <property type="protein sequence ID" value="KHJ34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBN3"/>
    <dbReference type="SMR" id="A0A0B1PBN3"/>
    <dbReference type="STRING" id="52586.A0A0B1PBN3"/>
    <dbReference type="HOGENOM" id="CLU_562831_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF1">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="234"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="52373" checksum="C45B923AA225BD15" modified="2015-03-04" version="1">MRSAMFLKNYFVNITINPRRLLVISLLVSTCVQGQKDVDSKCKNLGPNSNSVCESQTMLFAFEDDKSNSNTTKIDEKDVTANDLDERNNNGNCSSVGVIYARGLSEPGNLGILTGPPFFDAIDNKVENEDVAIQGVNYPDSKPSDEVEGSPEAVKVPPEAAKELARIITESRNKCPDMHLIVSGYSEGSQVVHEATDQLSPEISNGIGAIIMFGDPMKGTPIKNYDAKKVLTVCHDGDVICDGKPEVRPPHLTYSQDANDAAEFAVKTMGHIGITSYDHTFCKFCNGFHHKKPWFKYKPYHKHPYFYRPRPYHYHYGFGYGYGYGYGYGYGWGYKHGSSADSANMQSSPEEPSANPDKPSANSGEPSANPDKPSANPDKPSASPDKPSANSGEPSANPDKPSANPDKPSASPDKPSANSGEPSANPDKPSANPDKPSASPDKPSANSGEAPAKPGSSTSVPEGASTETEKSAITSMRRLKRRNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBR1</accession>
    <name>A0A0B1PBR1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g0022</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBR1"/>
    <dbReference type="STRING" id="52586.A0A0B1PBR1"/>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="364" mass="39839" checksum="732FCA234B518B2D" modified="2015-03-04" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNKPMILHQIEALALAGVTDIVLAVNYRPEIMEKALSEYATKFNIKITFSIESEPLGTAGPLKLAEDILGKDDSPFFVLNSDVICEYPFIKLANFHKQHGQEGTIVVTRVEEPSKYGVVVHKPNHPSRIDRFVEKPLDFVGNRINAGIYILNPSVLRRIELRPTSIEQETFPAICADGELHSFDLEGFWMDVGQPKDFLSGTCLYLSSLSKKNSKILAPVTTPYVHGGNVLIDPSAKIGKNCRIGPNVTIGQDVVVGDGVRLQRCVLLAGSKVKDHAWVKSTIVGWNSVVGKWARLENVSVLGDDVSIADEIYVNGGSILPHKSIKANVDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PC65</accession>
    <name>A0A0B1PC65_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000606">
        <property type="protein sequence ID" value="KHJ34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PC65"/>
    <dbReference type="STRING" id="52586.A0A0B1PC65"/>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="257"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="54918" checksum="76EC2B9632B6B471" modified="2015-03-04" version="1">MSTYQGNGALSRDVEVDSDVEEEALAADYHEQVQYEGIDEQDHFNYISLAQQADDIQARLIAAAQPLDFNATLDVKINSYDNFCSLFHFILNSDGPVQLEPPTNYWAWDIIDEFIYQFNSFCTYRNRVARQGSSNEEIQILREAPNTWGCYSVLNVLYSLIQRSQINEQLAAIKRDEDPMAVAGDYGSKPLYQLLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMMRRYTDAIRMFSHILIYVSRTKNFQKNAQYDSITKKNDQMYALIAICVAFNPTRLDEIISIALREKYGDQLLKLQRGGLDSLPIFEELFRSACPKFISPTPPDFDNPELDVDPVEHHLFIFMDEVKNNMWSPIVKSYLRLYTTMDLKKLAGFLEVEPDQLRAWLLVNKQRSRQIKWSENGLLDGDLITSNDLDYAMQGDLIHISEAKVGRKLIDWYLRNLARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ2</accession>
    <name>A0A0B1PCJ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative short chain dehydrogenase reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g3159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000177">
        <property type="protein sequence ID" value="KHJ35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ2"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OMA" id="DQKSHIE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="292" mass="31416" checksum="CDFA80D3FA54CE5E" modified="2015-03-04" version="1">MSTTNSKYLINHVFDVAGKVALVTGGGSGIGLMATQALAVNGAKVYIVGRTEEKLSAVVQSHGHDIAGEIIPITADITQKSEIARLVKEIESKEDCLCVLINNAGISGQKQEASAETAEEMRKNLFDDEGSTFDDWCNTYRTNVPQLFFMTMAFLPLLQKATNRNQGYSGTVINITSISGIVKKSQNHFGYNASKAAAIHLTKMLASEVAENRLKVRINSIAPGVFPSEMTACVSGSDQKSHIEKEKYEKVPARRPGRDEDMGGAILFAVTNQYLNGVTIAVDGGYILHAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCM8</accession>
    <name>A0A0B1PCM8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000743">
        <property type="protein sequence ID" value="KHJ34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCM8"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="23315" checksum="4BFC15E55EA2DBFF" modified="2015-03-04" version="1">MGVLKGRIVRIFLANPRYAEHIGRLHRHRVKVKISALPATYSKCRLVKGILKPVAPSDRLLPEKPQSRINSDIANSLLPQELADIIATRQRHEIAWHARLLISNEIEKEEVVAFKAYLRQAIANFAATDSPPSPARVLFNTRPNKGKGKGKGKGNEKSLAKKIVVATTRTVLSKTINPEMNNEVDLPNAPQTSDKTWAIVARKGIVIMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCW3</accession>
    <name>A0A0B1PCW3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transcription initiation factor tfiid subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g6347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000710">
        <property type="protein sequence ID" value="KHJ34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCW3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCW3"/>
    <dbReference type="HOGENOM" id="CLU_068315_0_1_1"/>
    <dbReference type="OMA" id="WNMKDEW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="247" mass="26880" checksum="07D97C701627B599" modified="2015-03-04" version="1">MADTNGEGPKTTGHASVPSGSTATLPAIPNPNVPLTSNQDSGHSKRPRDARLIHLLLSSLGCTAYQERVPLQLLDFAYRHSSSVLSDALHLSSDAYISQQVRARDAPPGGLQRDDGQVSASTVQLAIQSRLQYQFGGGNGSGLNKEFLMEIALARNRVSLPRVLQNEWGVRLPSERFVLTGVPWGLKGEWKLETEVEEACVNEQVTEKQVEDIEMKDEEVEEGNEEGGTMEDLFGADVDSDMGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD21</accession>
    <name>A0A0B1PD21_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000678">
        <property type="protein sequence ID" value="KHJ34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD21"/>
    <dbReference type="STRING" id="52586.A0A0B1PD21"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="OMA" id="CVIKDSG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079919" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="279" mass="30627" checksum="F8C1E9AE058C41F9" modified="2015-03-04" version="1">MKKIFISFFICTLVLALLTQTVQAADDPIITHKVYFDVSHDDKHLGRIVMGLYGKTVPKTAENFRVLATGEKEKGFGYEGSTFHRVIKDFMIQGGDFTRGDGTGGKSIYGDKFADENFILKHSKKGLLSMANSGSDTNGSQFFITTSTPSHLNGLHVVFGEVLEGYDIVEQIQSVPKDYGDRPLKTVKITKSGELPMSHEDDHGNTEFQHGEIISQSSPAPSGYTEGSVIVIPASGIDAEGFTFLQKGVSIIFIFSCIAVYIRLKIKARQSCEKKTLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDC3</accession>
    <name>A0A0B1PDC3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000607">
        <property type="protein sequence ID" value="KHJ34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDC3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDC3"/>
    <dbReference type="HOGENOM" id="CLU_008720_1_0_1"/>
    <dbReference type="OMA" id="HHLVRNF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="762" mass="86325" checksum="C5BC4984F9A19715" modified="2015-03-04" version="1">MPKEQKISRKQKAGEILKRKRNLDSADVDENPRKRRASNENDWDNDYIKIDEEKDFNTLPFYGLLGDEEQEYFRRSDELLELNDFPDEETRSFFLANVFREAENKELKIACSQSCSRLMERLILLCSTDQKKTLFQKFSGNFVHLIRHRFASHCCEMLFIQSAPIVTEELTSKSSTGKSSKSDFPTMENLFLQTLDEIEGCMSSLLTDVFASHTLRVLLMILDGRTLGQHTSKTLVQSKRKEKIEIMALETKQNENLLEKRQVPPSFTFAVEKIISDIASSLDPPFIRLLATHPTGNPTLQLLLELELTSPNLKEMSKLGQNSIISSILPDAIDVENSNSVSLINGLLYDSIGSRLLETICMFASGKLFKKIYQIVFKDRIAAILRNEISSYTAIRVLSRIGKQDLEEALQLIIPQIPKLVERNRSLAIRTLIERCHARCIDTSALTSSISEAYGGHRETLILKMTCLDTTTLLSMTSLQHEGETEIEKDNKQKPSHSQLQGSLLAQSMLMLQGPSSELIQDALISLPPQILLSLSLYTTTSHLIQSALSPTLPVLFRRKLINLLLFSLHCPSSDRQIPILRLCLSSVGSHVLDALLTCTIHPSTLSPHSDSKNSTNSATPLFSYAERISSVLVAHEHEIRNSFYGRIIWRNWSIDLFKRMRSDWVRKVKNFYLTTIPIPSRSQSMNSSTKTTMIMNNNETEVSCKTSNHPSIKIDAEIKKDKSTIRPPRRPESNGKSAIELARERFASKKLMSSSVKKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDN1</accession>
    <name>A0A0B1PDN1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000717">
        <property type="protein sequence ID" value="KHJ34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDN1"/>
    <dbReference type="HOGENOM" id="CLU_2689642_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="74" mass="8483" checksum="BAE2FF88FD3B7260" modified="2015-03-04" version="1">MFVVEINSIGAEILGRVEPTANERLNVLLLVGPEDSGSEDFLDRITVRARASDILNSDEYVYRRLFLDNMVKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDP8</accession>
    <name>A0A0B1PDP8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g5001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000709">
        <property type="protein sequence ID" value="KHJ34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDP8"/>
    <dbReference type="STRING" id="52586.A0A0B1PDP8"/>
    <dbReference type="HOGENOM" id="CLU_033172_3_2_1"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="90"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="400" mass="44338" checksum="9AB959F153740F7F" modified="2015-03-04" version="1">MKGHKLLVLVSKGRASFQSCRLHPFAKEYGTVPRPDPFSFPPPSTFETAIKAKKIRHDWTKNEINDIYITPLMKLAFAAGNVHRKFHNPDAIQMCTLMNIKTGGCSEDCSYCAQSSRYNTGLKATKMVTVDSVLEAAKIAKQNGSTRFCMGAAWRDMRGRKSGLKNIKEMVTGVRNMGMECCVTLGMIDLEQAMELKEAGLTAYNHNVDTSREHYPSVITTRTYDERLQTIANVRDAGLSVCTGGILGLGEKAEDHIGLIYTVATMPAHPESFPVNTLVPIKGTPLGDTPKIPFDAILRTIATARIVMPQTIIRLAAGRTTLSEEQQVLCFMAGANAVFTGEKMLTTPCNGWDEDNQIFYKWGLRPMESFEVNAWREQFAVEMAPESQEKKDVDPLVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDV5</accession>
    <name>A0A0B1PDV5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000357">
        <property type="protein sequence ID" value="KHJ35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDV5"/>
    <dbReference type="HOGENOM" id="CLU_449752_0_0_1"/>
    <dbReference type="OMA" id="TIHEASW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="602" mass="66396" checksum="C008B7A4DBA8CA56" modified="2015-03-04" version="1">MTDFSTKIGPSTNIVSEQSGDGEKRNIRNSALKIFHRYRRHKSISSGTPLISDTSSPIRKGLSVRSNSASSASIDKSNRTSFRPFERRTPRSFTSELGTVTVLKPVSEFSEPYCPSYNPLRDSTQSRGSIGRELQKKIQTLSYVEASSSREFEHKCNSPLKKSQETVGPVATLAIPKTEAVLTAQNGKWARQDSPTTESLRSERSSSRISNSTFSRAYPSEVSTSRGTSPDLYPPRTSSKYYYQYNNERLVNTERNSDPSNDDLSTMQSKKQEESSSNSSLVFTTGTAKLARSFSGAGIEKPCIVRCSSPSINLGASSVGKSSFSNTSRPNTPVSIQLRNENSQSSLEYKGTIHEASWIAPVKLGRTNTKSVQENNGNRCLNRSSGLRSHNYSNPAPSVGQSTSSTSKSSQSISISRIMTVAKLTPDFEQFNDPALVTISHRNSKKLSSVPAIAIATPLNYASSDSEDLETDTRYSFRKQHSMNSLRSVDPFLSHPRAIRRSEIITSGSVSIRELDLNTRLCKMERDNALLLSALEDIVKKFGGSGVSGNSSLRYEEENGSSEVSMALEKKPHWCDVGVRDEYPSSNVEGEQTRTLFNRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE01</accession>
    <name>A0A0B1PE01_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative qde-2-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000661">
        <property type="protein sequence ID" value="KHJ34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE01"/>
    <dbReference type="STRING" id="52586.A0A0B1PE01"/>
    <dbReference type="HOGENOM" id="CLU_016815_2_0_1"/>
    <dbReference type="OMA" id="CVDVESY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="620" mass="70618" checksum="704603603948CDA2" modified="2015-03-04" version="1">MVKAQNIYEGSDSEELEIEPEPPVAPEISDTVSDDESSDEIPLPQKTPKAKRVPKPFKPFVLGYSPRAGELCREDEKFCTFQLVKSYPYQYIGKANRQRVDDTYFNQGKVFANSWELFYLHRNLLKLEGSPPPLILVTTRQFIHFLAKINKHFKTKLAIPDGANGAFEVLFGGEGTPRPRYLGQANSKLAMENLIYKVPSWRFKLDGEPEMAQVLTDETYEIFLNNVALAQQKQPKKAVAKEKVIKSRIHNQKSWRQTVKRVQRYLGLRQALETSSSLQQPFSNQKTVKSATDTLAKFSFNPNFVTHFIQENSVIFVCVDVEAYERDSRIITEIGFATLDTKDLLTLPPGERGANWRTLIRPRHFRISEHKFYNNSDYVAGCADRFEFGKSEFISIKDTPQIISDCFKNPNFKSGEEDAVDLTNRKVVFVGHDIISDIKFLRTVGYDVYTLPNLFDMVDTALMYRALKREMNTRSLGVILTDMGITGWNLHNAGNDAVYTLQAMIAIAIKFLGERQNHNKIHIPMNSEDRSKPTAQKEEAWSSSGESDGGLPNLFYLTFPDYNSGNRNKRGFSNPRASNERTSWADRAREGSSSQSKSTRPSNATDRPGFSSTRSTRRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE28</accession>
    <name>A0A0B1PE28_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000633">
        <property type="protein sequence ID" value="KHJ34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE28"/>
    <dbReference type="STRING" id="52586.A0A0B1PE28"/>
    <dbReference type="HOGENOM" id="CLU_037141_0_0_1"/>
    <dbReference type="OMA" id="QTIGYHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="64054" checksum="5CC526394530E028" modified="2015-03-04" version="1">MDSLPTELLWQILAWEVQICRYEKNAIVPLRLVCHAFDSALKPYIFKTVQLEFSRLLRCARNYRQENRMDFGRLKEFGLLTEALHLDLMVVRDPEEIESFDNIFHGIINRLPEIAKLSEKFKRYCMGTTSFDERDFRFVLEEILQWTPNMCRVRVNLPLQILGWKSRTATLLFATTLECLAKRIDEHQAIQTLVVDHLTDTALINICNNPMDLANAIKVFSSVLHLCISIKTEEISPNRQDAFGWYLWFMIRKARALTSLCLVGWNTKQEIRSRRYDSGVRFEIWNTRSLSFFSGDTNWEFLRNLELKSVYFRPSKFLEFIGEIKNCLRELYLFEVYLRVHRLPNNEISGLWVGKVGVNKPEGSVWVAEELRNMEGLNLKILRATGLEYDRFDVNPQPTDPEFDFLDPLNRPYDQRFVDAVILGPEKIFLTLYKDDNIDKDLSSRSEIITNGRLENKDCTVYSNLKVTLKKKLNFTPRERKDYDAETYQRSRNTTSHFKRCIDGCFFNQNERVLRELRSIVAIADRGMNLLSEEIYRARSEGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE84</accession>
    <name>A0A0B1PE84_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g1039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000313">
        <property type="protein sequence ID" value="KHJ35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE84"/>
    <dbReference type="STRING" id="52586.A0A0B1PE84"/>
    <dbReference type="HOGENOM" id="CLU_011501_0_0_1"/>
    <dbReference type="OMA" id="PPALPFM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="236"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="731" mass="83125" checksum="A3495DF178DD244B" modified="2015-03-04" version="1">MGKPGELYLLSDKSLPQAIIPGLISYCPSIDLVALSTTENHVSVYRLNGQLVYGVAQKPNDLRVDSLHWKPNGKLFAVAWSDGCVRLINAESGKTVHQFTNDHQVSKVTCMGWCSNKMINSTASSFCYISKEIEKFMQNENSDFLEDQVLPLDLPRDVSLIDIETSLPKLSTLPAGGDSEDIFCTRSSLDALISPFDPKDNDAVDVMIFGTKEGKIHIIIYDSFFIGSFESPLSVKGKWKASRELPDKFLRSINETLNQNYQCGIVQALCHSLATGHIYPPVKEWLMHEISERGHKRWEKAVLTGLGNLKRIIHENMLPALERFTVILSRFIGIAKFQPLNETVGFTSQHISLLMDTIACLHLIFSKILSQVVDEIDLFTYFSAWIRYEIDKLTSDFSSTLAEDTTEKESLIDHSKVFFYLQTILTCTPLADHFRESLSLDDTSEFSQTQEPLFEIISQHLKNKNQGLDYNKSVLSVKFHCDELSIKAVNLFQRIAGSEKCNVIFGKEIPIGIAEPHTPMDLRLEMKDISTFPSYFAFVPKGMPNCVRVVRVKIPLKKDDSLYDCLESFTIQLGEGSVEDIKYFDGDSLFILWKSDQESTKLLNLPYKEAVKATSLQATNYVELTSDLKLEYSPYTHTPSYNSLSASNITRPDIFIETKNVTKYFSKYEIPSEDHQFKPEYLSVRKILGKNHYQHYEQMTKLKTNTEDDQRIILLDQGGFHYRVYSTTKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PES8</accession>
    <name>A0A0B1PES8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000403">
        <property type="protein sequence ID" value="KHJ35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PES8"/>
    <dbReference type="STRING" id="52586.A0A0B1PES8"/>
    <dbReference type="HOGENOM" id="CLU_019711_0_0_1"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="699" mass="79260" checksum="A5CF1CF7006CBDE9" modified="2015-03-04" version="1">MVAPAVPELTEEVLHESIDARTEVLVTLRELGPPDLVQLIKQSPRNPAKTIGVYHHVTGVDASSSASLAAYINTLTYKENHQQTQKIVEGVYCCYNAFSRLDMRVHVNIPGSVESYAVDERGEKKVASDELWLETYLCSVLRAYSYGDCGSGEKIRKIIGVRRFNPVTNTEAEHKFLQAAEQLFFRGWQLGSSSVVQVPNNVSNHLTSGLLKYFQTTGRFTSGINLFEKLSTKNIEVSSLLAKVFLMGNEEVQAVRVLHNSIKQSPMDYVMLDTQAEFLLKKAMNPKSQKLKQEWLQMALGCADRSTVAAPSEFGTWARLAEVYVAMENWEDALTTLNSCPMFTYQDKDIPVMPEPKDIYLPMLPETRLDEIDSEPESRYSDQVHPSLLSLRATQYKGTFKHAYSILTDMTAKIGWDQLLKIRSNVFVMEEEYRSERNSSSGLHEPPTVRNPSMEGLRGSLDKKVNGKDSIDGANGSDKDSDMISPNTISPRSSRDKAPNHAVEEPLHTAKPEENKSKGEETSREQLSRFNNKRLCERWLDSLFMVLYEDLRIYTIWRTEMAQFRAQQMQYKKSAEEWEILGSLAERLHHRSEAMEAYRACLSIRFSPKALKGILSEFEAEKSTRDIVASVIRLITWQYRWYSEFSPELLLTVRTLIEDEGAVKIRSIIQATSLPQNVLELTHHYAALCATFRSSGTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFF9</accession>
    <name>A0A0B1PFF9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ell-associated factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000317">
        <property type="protein sequence ID" value="KHJ35631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFF9"/>
    <dbReference type="HOGENOM" id="CLU_083689_0_0_1"/>
    <dbReference type="OMA" id="NTFVEMS"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="272" mass="31051" checksum="9AD46831EED0DBDA" modified="2015-03-04" version="1">MDVGFGNYPIVLSDALLGKATKELYTGIRYNHKANDTTYPSSNSCRLQPNEEDPSIFYLSHLNNSEKLSYSGKRTVEENQFVLIFDPDKEHFILHRLDSNFDLMPISPSSDSQEISSKTQSSIRQKRSSKDTIKVSDSNKESSRRKIEKAKTVQKTIRELTPEEDFDDGLTIEYPGGQSQDQFNAYSSPIPIYHREMRESCERDDEVLQDDDGFLDHDFNNNKEFSPPNEPPAEISDEDIEMALEAELEQELLKDSAGQTVDDNESDESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFG6</accession>
    <name>A0A0B1PFG6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000448">
        <property type="protein sequence ID" value="KHJ35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFG6"/>
    <dbReference type="STRING" id="52586.A0A0B1PFG6"/>
    <dbReference type="HOGENOM" id="CLU_048127_1_1_1"/>
    <dbReference type="OMA" id="NAKEYRM"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="285" mass="33084" checksum="8B34D4891877CA12" modified="2015-03-04" version="1">MASIITQFEFEEALGRYDSMISKMKKETKSGAASLKELDEFRYETVIMKFNKSTGDTMDISDVEKLIEWKMLHGTFRPNLRKLISSNSNNTLAVTTKNAFEYYATNKFDVSGTLEILSKPLKGIGPAAASLLLSIHDPQNVVYFSDELYKFLCSNGKKVSLKYSFKEYKKLHESAKDFMERIQCTPIELEKVAYVLIKEQEQYQKQSPRKDRALVSLEENPGLSIFEHEQPKYLKNHQRHPETRRSGEEKKRKRHQSPQDLCDEISREAIEPLTKAKRQRNIQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFW0</accession>
    <name>A0A0B1PFW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative co-chaperone for hsp40p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000380">
        <property type="protein sequence ID" value="KHJ35469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFW0"/>
    <dbReference type="STRING" id="52586.A0A0B1PFW0"/>
    <dbReference type="HOGENOM" id="CLU_043579_1_0_1"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="357" mass="40339" checksum="B42C94FB8B1EF533" modified="2015-03-04" version="1">MPSATASGTDSKNNGSARSRNHNQGNQERKYTTEQKAEVIRVRRCSPTAFYDILGLEKSRTTVTDTEIKKAYRRISLLTHPDKNGHEHADEAFKMVSRAFGVLGDKDKRAKYDRFGGDPDSRFGGQQSSSPFSGFSEGRTPRNNNGAWDWQQELTPEEMFRRFFGGGPMGGFGRFDTGPGFVFNMAGGPGIRVQQFGGATPRRRPRGQNSQEEPPASLRQVIMGLLPLLMILFLPFISSILSGSSSTETGPSMRFDNAIPPHTLHRHTSRLNVDYYINPKDVDSYTNSQWKTLDKKAEINYINRLNLDCQQEELIKKELINQAYGWFFTDQEKLNKAYTMPMIACSKLEKLGKRQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGQ3</accession>
    <name>A0A0B1PGQ3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Cytoplasmic vesicle</location>
            <location evidence="6 7">COPI-coated vesicle membrane</location>
            <topology evidence="6 7">Peripheral membrane protein</topology>
            <orientation evidence="6 7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 7">Golgi apparatus membrane</location>
            <topology evidence="6 7">Peripheral membrane protein</topology>
            <orientation evidence="6 7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000020">
        <property type="protein sequence ID" value="KHJ36435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGQ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PGQ3"/>
    <dbReference type="HOGENOM" id="CLU_076799_0_0_1"/>
    <dbReference type="OMA" id="NQRYIYT"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="251" mass="28570" checksum="9DA3C5537FA57460" modified="2015-03-04" version="1">MVVLAASICTRGGKAVLSRQFREISRSRIEALLASLPKLADTGTQHTTVEQDSVRFVYQPLDELYMVLVTNRQSNILQDIDTLHVFVQVITSICKSLEEREILKNAYELLSAFDEIVSQGYRENLTINQIKSFLEMESHEERIQEIISRNKELEATEERKRKAKQLEIQRKEASRGGRTTIPRAPVYPTYTSSTRSPVTDTYDAYEAEKNKFKAPISKGKGMQLGKKSKANEIFERVKEDFESEGESVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGY0</accession>
    <name>A0A0B1PGY0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000267">
        <property type="protein sequence ID" value="KHJ35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGY0"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="18416" checksum="3616814B25A200B8" modified="2015-03-04" version="1">MTDSMEISQESLAPTTDLSHQLSPIPLVPPIPNPPPSIASTSPPSQTTSNNISTHRQILKPVAPSKRPIPDRPHHNSRNNSDIANAFLPQELADIIATRQRRERAWHAQLMICLTVISSIDGTLATFTKEVEIEEAVAFKAYLKLAIANFTAVDSSPPPPRVPLHTVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGZ0</accession>
    <name>A0A0B1PGZ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative t-snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000144">
        <property type="protein sequence ID" value="KHJ36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGZ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PGZ0"/>
    <dbReference type="HOGENOM" id="CLU_047847_1_0_1"/>
    <dbReference type="OMA" id="RVQSEMM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="38139" checksum="EFEEE79F86ACC77B" modified="2015-03-04" version="1">MTDLLPLFNELLKKYDASPITSQPLILSRFDHFIDEAYKINTRINEVKVFLKDIRPSYLAKDIHTRRLNSIAKKRRSKFLTDRDKEEIDAKIKQIFRELDAGIRVLAEAEDVRRQTEISLIRRKYGHWGLGSLGTWAIGGIGELKSPEQEQEEFRVNTISAHRENVLYFLRHRLQKWANQQASMMEKRISREIERNRNLLGQVRLDQISDTEYADLKINHELSSEQIQIFEKDNQDMVQRYETTLNQVRVAEKSLVEISELQNQLVHNLSVQSAHIEQLIADSHLTSENVGGGNKQLKEASQRKSTAKYVFYASCGLSLSLVIWDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH65</accession>
    <name>A0A0B1PH65_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000121">
        <property type="protein sequence ID" value="KHJ36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH65"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="253" mass="27724" checksum="E84C517951C4013E" modified="2015-03-04" version="1">MGITQETQALSTETSIEPPPIPNTLPSTTSSTQPSHSQTLHNTTASRKILKPAVPIKRPIPERPPQNNKNSSDVTNSYLPRELAEIVANRQHRKRVWHAHLMICTTIHSCIESNLLNFLNEIEKEEAAAFKDYIHTAITNFAAVDSSPSPPQIPAHTRPTKGDGTVKDESFAKKAVIALPQKPMGAVVYKGVEKETSSLLVNTWATVTRAGHKKARMMLSSKTQVNPTGRQAHRMANKVKPNSSASQTMAISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHQ1</accession>
    <name>A0A0B1PHQ1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="JNVN01000154">
        <property type="protein sequence ID" value="KHJ36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHQ1"/>
    <dbReference type="STRING" id="52586.A0A0B1PHQ1"/>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="269" mass="30683" checksum="62C63427000280F7" modified="2015-03-04" version="1">MNTSYPPLQTRQISNTIVLFDVDGTLTPARRRATPEMLQLLAELRKKVAIGYVGGSNFDKQQEQLGTSGVSITTLFDFCFAENGLVAYKLGDPLPSNSFIKWIGEARYKELVNFILHYVADLDIPVKRGTFVEFRNGMVNVSPVGRNASTEERNEYEKYDLEHKIREKFISAIQNKFADIGLTYSIGGQISFDIFPTGWDKTYCLRHLENEASKSEGIQYKTIHFFGDKTMKGGNDYEIYNDPRVIGHAVNSPEETYNEIKKLFDIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PHZ4</accession>
    <name>A0A0B1PHZ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000131">
        <property type="protein sequence ID" value="KHJ36134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PHZ4"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="18900" checksum="0CE998A60708B5BD" modified="2015-03-04" version="1">MDISQESQALSTESSRNQPQIPHPLARHPHNRQTLNFQLPSEPLVERPILKPTAPSKCPLPDKISKNSSENTGNENVFLPKELAEIIATRQRRERAWHVRLMIFTTVLSNIDSTLANLDEDIEKEEAEAFKAYIRLAISNFAAADSAPTPPRVPIHTRPIKGNGNVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI09</accession>
    <name>A0A0B1PI09_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative serine esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000027">
        <property type="protein sequence ID" value="KHJ36426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI09"/>
    <dbReference type="HOGENOM" id="CLU_2514318_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ36426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="85" mass="9541" checksum="41207EB7FF7356A6" modified="2015-03-04" version="1">MQPLFAPPQTSVFESAGDLLVLPLPTVEYLLNLSSRSQNIFHDRIPDPVQEKKDYMKLSPETLSSTSDKISGSFFEIAQVNIFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI38</accession>
    <name>A0A0B1PI38_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g1177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000015">
        <property type="protein sequence ID" value="KHJ36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI38"/>
    <dbReference type="STRING" id="52586.A0A0B1PI38"/>
    <dbReference type="HOGENOM" id="CLU_076417_0_1_1"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="234" mass="26348" checksum="40755BC121607FF5" modified="2015-03-04" version="1">MKQALQAYAPTPYSYIPQPVNTLINLDEEVKLTETRADRDLQDSLAEVFSIIVTLDQIEKAYIKDAIPEASYTEICDRLLKQYKAILTDDAVASEFVDLEKFKSKWDIEVPRATERIRIGLPSTVTATSINTSNSQSSNINGALILEATQDFITFLDALKLGLLAKDQLHPLLSDVIQSVNKVTNKDFEGRGKIVKWLIMLNQMKATEEVNEDQARELELDMNSAYQGFKTTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PJ02</accession>
    <name>A0A0B1PJ02_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000012">
        <property type="protein sequence ID" value="KHJ36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PJ02"/>
    <dbReference type="HOGENOM" id="CLU_1316267_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="209" mass="23718" checksum="587DC5FA31973AF6" modified="2015-03-04" version="1">MELLSISRDGWETSSQSITNRAQHVTPPSSTTPPTSVVENRKIIKPVLPSKRAAQNAAVIDLTNDKNNRTSSHAYLPQELTNIVLARQRQERAWHIRLSICTCILSNVESTFSIYKEDIEKEEANVIRKYLQKAIAHLVASDNAPQPPEIPIESKPSKMKSSNLPRNSKIIDSHVLMWLTQKHPLFLRKITTLISRDKSLVRNKKKIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVM9</accession>
    <name>A0A0B1NVM9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004317">
        <property type="protein sequence ID" value="KHJ30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVM9"/>
    <dbReference type="STRING" id="52586.A0A0B1NVM9"/>
    <dbReference type="HOGENOM" id="CLU_000680_23_6_1"/>
    <dbReference type="OMA" id="ECHERIM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="420" mass="47240" checksum="87F28D175C14BC54" modified="2015-03-04" version="1">MGKLLEKLVANRISKAAEEFNLLPEEQMGARPKRSTISAVELLTEQIHTIWGKDKRQVASLLSLDISRALDNVSHERLIHNMRQNGIPKWISQFVVSFLEVRTTSVVLGTFKGEQIPTSTGIPQGSSLSPILFLFFVSTLLPMLQSRSTAAVGFVDDKNILTWSNTTEENSRKLEEQHEICERWAKTHGIKFAPEKYQLMHFTRARKKRHNLEATVKIKGQLTKPQSSLRVLGIYFDPKLNWGAHVKSIQEKSNNQIQSISRLAQSTWGATFKKSKLLYSTIVRPALTYGSSIWAEAGPAGKIPERIVKPLRSIQRKSLKIVTGAYNSTSCRVLEHECSILPIEIYLKQRRVQYGGLLDQLPVQQTIQAACKKIKPSAGGRESTHAANRSKDVSEWARICSKETSKRRQKGAGKIAAFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW04</accession>
    <name>A0A0B1NW04_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003978">
        <property type="protein sequence ID" value="KHJ30562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW04"/>
    <dbReference type="STRING" id="52586.A0A0B1NW04"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ30562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="542" mass="59014" checksum="9B4285AA5A82C0CA" modified="2015-03-04" version="1">MSQASVVKDEQGRPFIVVRDQGTKKRQHGIEAIKSHIIAARTVAKILKTSLGPRGLDKILISPDGDITITNDGATILGQIEISNHLAKLLVELSRSQDDEIGDGTTGVVVLAGALLEHAAELIDKGIHPIKVADGYDQACDIAVAELDRIADVIEFTKTERENLVKVARTSLGSKIVSKAHDQFANIAVDAIMSVADLERKDVDFDLIKVDGKVGGSLEDSMLIQGVLVDKDFSHPQMPSEVRNAKIAILTCAFEPPKPKTKHKLDVTTVEEFKKLQNYEKEKFAEMVKQIKDTGANIVICQWGFDDEANHLLLQNKLPAVRWVGGPEIELIAIATNGRIVPRFEDLSPAKLGTAGIVRELSFGTTREKMLVIEECANTRAVTAFIRGSNKMIIDEAKRSLHDALCVVRNLIRDNRVVYGGGASEISCSLAVENAAVKSPGIEQYAMRAFAEALDAIPMALAENSGLSPIETLANIKSRQVTEGNSRLGVDCLQKGTNDMKEIHVIDPLIGKRQQLMLATQLCRMVLKVNSVIIAGADENEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NWX6</accession>
    <name>A0A0B1NWX6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytosolic copper metallochaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004162">
        <property type="protein sequence ID" value="KHJ30478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NWX6"/>
    <dbReference type="STRING" id="52586.A0A0B1NWX6"/>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="OMA" id="YEFDIAM"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ30478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="93" mass="9999" checksum="F995FA1E58F2485D" modified="2015-03-04" version="1">MSTTQTQSHTYKFGVVMPCGGCSGAITRVLDKLEGLESFDVSLENQLATVITRDDTVSYETVLKTIHKTGKKITSGEADGKTMSIDVPTEPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYG6</accession>
    <name>A0A0B1NYG6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome c mitochondrial import factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002903">
        <property type="protein sequence ID" value="KHJ31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYG6"/>
    <dbReference type="STRING" id="52586.A0A0B1NYG6"/>
    <dbReference type="HOGENOM" id="CLU_003827_6_0_1"/>
    <dbReference type="OMA" id="GCLRFFI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="442" mass="50950" checksum="1435E801E22C2E19" modified="2015-03-04" version="1">MISLNKFNLHPGQVSATLIFKSYLVNSVMFNKMAVSRLYNQPFSVLISCRDMRMVRWRQRVGKLKSIDRVFNMTKNSSTSIFGRASNLNSRTEYFKVYQDSDLVQKSKISSFGPRYIKLAFASLSLSIFGWLIAENFILQNQNDGIFNPPKFTPFEIIKKEAISSTAFILSLRSIQKHPDMCEPDPFEKWWTKGIWSVEVKQPELQISRSYTPLPPLRGEPLDYITFLIRKNYRGEMTGYLNRLQEKSIIQLRGPYQELEIPPTVNQILFLAGGTGISPALQIIHKFLERRNLKDIKPSIHIVWANRRREDCYNGFSSENKDDRAIFPGSRENQNNNPIVDYLNRMQQLHPDELTIQYFVDEEGSKLNSKTLAKLIQKFSKNMPENSLSQSQTQSRLLLVSGPEGFIEFIAGAKKLLGSQDQGELDGILKNIEMKNWGVWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYS3</accession>
    <name>A0A0B1NYS3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004837">
        <property type="protein sequence ID" value="KHJ30185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYS3"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="195" mass="21546" checksum="55ACAC888C26A323" modified="2015-03-04" version="1">MICTTVISSIDSTLATFTKEVEKEEAVAFKAYLKLAIANFAAVDSSPPPPRVPLHTRSNKGNGNDSSKGKSKEKNLSKIAVAIPRIASNQNQNLGTIKEVELPKIIKNNDISWATVARKGQKKARMVQNINTHEIKRNKESQKVSYKDNSSTSASDKMLFVRLPQDHEWRNLSPAGIREVIVKKLLISPSLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYZ5</accession>
    <name>A0A0B1NYZ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002719">
        <property type="protein sequence ID" value="KHJ31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYZ5"/>
    <dbReference type="STRING" id="52586.A0A0B1NYZ5"/>
    <dbReference type="HOGENOM" id="CLU_1284119_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="215" mass="24304" checksum="DD4F0F7F20AE1A31" modified="2015-03-04" version="1">MITPTIVPASTERTRKRFSLTSIILGFFPGLVIGGLIIVVVFYIRKFYIKKKREAKGTRSIKHISAPQPINDVRTDFLGIYASKSPAVFRETSPFDKSDAYTQEVSIYKMPSNSSLDLDEVLKTPLPPVPLNIRKQAPSVPPNHLSGTDSNRMNSFMNVSYSFENKPIIQISSARELDHIPQNLEDLQDYQRGNLLLADKLRNPRESYVYKGAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ15</accession>
    <name>A0A0B1NZ15_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004613">
        <property type="protein sequence ID" value="KHJ30265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ15"/>
    <dbReference type="HOGENOM" id="CLU_2470746_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="88" mass="10127" checksum="CD889499C50BF559" modified="2015-03-04" version="1">MDLSASNLKPQTSNLNHYITWTSDDAANHRIPRNEAERCAKRAYCFENKLCSWCYDPGYRARVCAEAKWNKGKTKSAENKTVIEQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ25</accession>
    <name>A0A0B1NZ25_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative isovaleryl-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g4882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002694">
        <property type="protein sequence ID" value="KHJ31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ25"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ25"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="58"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="281"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ31657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="436" mass="47578" checksum="19B97806EC497CF4" modified="2015-03-04" version="1">MSTCTLAFRNYIMFKKRLIRTWAVMPVQVKPVITTISVKSRQISSKHPKGFKPPTYTELNELRDRVQDFVRRVIPEEIAAKTDKSNNFPSGMWQQIGDAGFLGITADEDVGGLAMGYQAHCIVMEEISRASGSIGLSYAAHSQLCVNQIQLNGNSAQKLKYLPSLVAGTSVGALAMSETGAGSDVVSMKTMAIAANGGFVLNGSKMWITNGPDADIMVVYAKTDPHRSSKGITAFIVEKDFEGLSCARKLDKMGMRGSNTGELVFDNVFVPKENVLGEVNCGVKVLMEGLDIERLVLSAGPLGIMQSSLDISLPFTHQRKQFGAPIAHNQLVQGKLADMYTKLQAAKSFTYAVARKLDEYGQINTKDCAGTIMYAAERATECSLDCIQLLGGMGYVEEMPASRLLRDAKLYEIGAGTTEIRKIVIGRAFNKEYDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZL1</accession>
    <name>A0A0B1NZL1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002909">
        <property type="protein sequence ID" value="KHJ31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZL1"/>
    <dbReference type="STRING" id="52586.A0A0B1NZL1"/>
    <dbReference type="HOGENOM" id="CLU_582917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="390" mass="43082" checksum="66333176E9A20AF6" modified="2015-03-04" version="1">MNNSDHNFPSSPTPQVNTSTQLRAEASDPMPSKSGRLHPSLLSIANAMQQLETERRERMGLAQEFLEIIDAWAKGKTGTKAEAIIVPLIQKIAPTVTAFATGAVEGALLVPTSTHKAKNFQSLTRKSAIPLPKEPDGNKKETESNDPKEDKRLFLRLRPDHAWRKLSPIAIKKMITEKAGVAATAITALYSARSGYAIECVSDALRDTILTAGKSLGDTDAIIEAASDWTSLLVPNVPLRIRTLDSNVIFTSEMVANECLAVCGMLAIQLRPMKSSTGQIYTSWLIHFKKRPVDIHFRLFDESGPAMAFKRRRPIEQCQKCWGFHSTRFCGKDSHCGKCKGSHETEKCEAKTPKCSNCNGPHMSTDVKCMARPRRQANTSFHVPLQNSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZN7</accession>
    <name>A0A0B1NZN7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sucrase ferredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005016">
        <property type="protein sequence ID" value="KHJ30136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZN7"/>
    <dbReference type="STRING" id="52586.A0A0B1NZN7"/>
    <dbReference type="HOGENOM" id="CLU_033921_1_1_1"/>
    <dbReference type="OMA" id="CTIKYPA"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ30136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="346" mass="38299" checksum="27521058F2C1D0EC" modified="2015-03-04" version="1">MASIIPTLIKKVWGSSLGENTLKASPKTCVSVTDLFARVESGNECDYDCTSCVIKYPKNFKIDEEDELYGTIQEWSTHLLVATGKSDWVRDVADEEGSVMEAIVKFANVKPNNGRLMLSASNIPIPSCSANYADPTSVLLLPAWIIIENVTPKSVDTLISEFINKGPVNSTYTCKHSPENISLPQNIEGLSSRPCPHSALILLCSQGTRDARCGQSAPLLKKEFERHLREYDLLRDLDDETPGGVGIYFISHVGGHRYAANVIIYRKENSFGLDYAESGEEASEAMSQSLHTDKGLGGAAQCIWLARVRPNQCQAIIKHTVLRGRVFRPETQLRGGFDRARKLYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZX8</accession>
    <name>A0A0B1NZX8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gpi transamidase component gpi16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003907">
        <property type="protein sequence ID" value="KHJ30595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZX8"/>
    <dbReference type="STRING" id="52586.A0A0B1NZX8"/>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061620" evidence="2">
        <location>
            <begin position="20"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="583" mass="66811" checksum="1E64A85E864C3FAD" modified="2015-03-04" version="1">MRTSYIHILLCFILQVISSSDYHEQLILRPLNPSLLLASFNFKSNSTLTEFNQQNFRYFPRSLGQILKHTNTKELHLRFSLGRWDAERWGARPWGGSKEGGTGVELWAWIEAETKEKADEKWLILTNALSGLFCASLNFIDSTKTTRPVMTFQPSGKHYFRTLENLNLLHGALPGEVVCTENLTPFLKLLPCKAKAGISSLLDGHKLFDANWQSMSIDVLPICSETREFQLQIIQTIDMVVDIQRSKRPRDNPIPRPVPREELRCDQSKPYNSEDTCFPLNNSDLEENWSLSGIFGRQLKGPCPLATDNAYPVCIIVPHSRDIFTFANTREHKNQAGDMRCYELGQNEDFEMILPQQELSEKIPLEQPLLYAERSFIGYGQERGGVQAILINPSLTESVEIVYFETLPWFMKLYLHTLKSRINGLNKDIILEMYYRPALDRKRGTLLEIKMLIPANSTVVLTYDFEKTVLRYTEYPPDANRGFDVAPAVITIGNFSIRTTSLLLSLPTPDFSMPYNVIILTSTVMALTFGFIFNIIVRRFVALDEAEKWDFRVVRFRLAAVIKTSLGRSYARVKNYGKSRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZZ2</accession>
    <name>A0A0B1NZZ2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cyclin ctk2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g0701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002456">
        <property type="protein sequence ID" value="KHJ31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZZ2"/>
    <dbReference type="STRING" id="52586.A0A0B1NZZ2"/>
    <dbReference type="HOGENOM" id="CLU_038278_1_0_1"/>
    <dbReference type="OMA" id="GITWIDN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="183"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="50257" checksum="79378B8918ADCAA8" modified="2015-03-04" version="1">MASTPHQSNGNKGASYNENNTSGSASSTRIKPKSRIHVSNQYIFQQQLQNQFRINSTISTREDNFGLLGIQTISDIRKALQLPVRTFCTAATYYHKFRLIHKDNEYQYQDAAAGALLTACKIEDTLKKSKEILCAAHNLKVLPSEQLSSDDSIFEGHSKIVIGLERLMLEASGFDFRVRYPQKHLVKITKELGLEKSFYLTAYNILIDLYRTLAPLKQTSATMSFACLELAALMMNEKEHLISRLHSTSLYKKCSTSRTEILETIFDLLDLYTHSHKSSIIGPLHFIDKFIQIQILLNQEIEQDPSLNRHSGIYEYTKVNGAKQTPKTPVTPASPEIRKNGNTNTSPVLLSPRSASSSRRSGTNATRGPEITIRFMLDAEQVRKEEEIVSEYFKTEYDEREIEVEEPIRPPPRPERTVRSLIRGREDRYHHYNSSKRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P073</accession>
    <name>A0A0B1P073_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g2619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002385">
        <property type="protein sequence ID" value="KHJ32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P073"/>
    <dbReference type="HOGENOM" id="CLU_034390_0_0_1"/>
    <dbReference type="OMA" id="HWHDPED"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40155" checksum="24616816B9D6869B" modified="2015-03-04" version="1">MADEALMQKIKNLNDLGLAVLICLIAHEHFLIGTTVSSQDEVTHELEQIVNNVFSLRYVTIEFSQSTTSDEFAQLIILSEINVSNSDAPTRNRSEKILNNSATFQFSSRSSATKFPSTPTSIFNVIIAKNLNNASKQVQNQVLELVRTKRLLSKSSIYHVPEQFLLIVVLAAGEGLDLTKHLNDYIFMSHFHNPQYSIDDQEENFNGDSSSSVVKLRSSQKEKCEKNSPVVSPQEIEKLSRFSESVSLSMEVKQYQMDIISFLRLHRAVAGGITASATKVFDKLAKCLATIHNLTFVTPSLVALAARKVYFHRIKKVKPENERSIKWGSDVEAVAALLKRITVEDILEEVLGNSGVEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0A9</accession>
    <name>A0A0B1P0A9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004545">
        <property type="protein sequence ID" value="KHJ30301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0A9"/>
    <dbReference type="STRING" id="52586.A0A0B1P0A9"/>
    <dbReference type="HOGENOM" id="CLU_000680_3_2_1"/>
    <dbReference type="OMA" id="XANTREE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="256" mass="29082" checksum="A308B9AA3C2474F5" modified="2015-03-04" version="1">MNLLGYHPKIFRKAEVVVLPKPNKRDLNSPRSWRPIILLPCLGKGLERLIAKRVSQAAVRQGVLSTQQFGALPKRSATDLVSCLVHDVERARSHGKLASLLTLDIKGAFDTVFSGCLKRRLHEQRWPNWLIMWVKSFMSNRSIKIRLGDTVTEETALHCGLPQGSPVLPILFMLYIEPILRVGKQRGNFIYADDIAILRTGRSLTECTEKITHNLERLLPWGQENALSFDPEKTELQHFTQAPRPKEYPGITFKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0M8</accession>
    <name>A0A0B1P0M8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002600">
        <property type="protein sequence ID" value="KHJ31778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0M8"/>
    <dbReference type="STRING" id="52586.A0A0B1P0M8"/>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="251"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="488" mass="56555" checksum="B5FDC6D2F92E982F" modified="2015-03-04" version="1">MSDDDDFMQDSDESYDFEYEEDEDEDNGDVNIENKYYNAKQMKTSEPEDAIKEFLEIPGLEKEKGDWGFKGLKQAVKIEFLLGKYNKASEHYAELLSYVKSAVTRNYSEKSINNILDFIEKGSDYPDAARCMENFYSLTLKSFQSSNNERLWLKTNIKLAKLYLDRKDYVALTKKLRELHKACEKDDGTDDPSKGTHSLEIYALEIQMYAELKNNNQLKRLYNRALEVKSGVPHPKIMGIIRECGGKMHMSEENWKDAQSDFFESFRNYDEAGSLQRIQVLKYLVLTTMLMDSDINPFESQETKPYKSDPRIAAMTDLVDAYQRDDIHKYETVIKNNSDLLADPFIAENINEVTRNMRTKAILRLVAPYTRFHLSFIEKSLQIPLAEVEDILSFLIVDMKIQGRINQQEGIVEIRDDSELERLHSMQEWSSAIGTLYRTIFTEGEGFKTPDVAQIENPPMGLFEEAMRNRNELSGSLCVKSKIYNNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P125</accession>
    <name>A0A0B1P125_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bzip transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g3758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002183">
        <property type="protein sequence ID" value="KHJ32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P125"/>
    <dbReference type="STRING" id="52586.A0A0B1P125"/>
    <dbReference type="HOGENOM" id="CLU_1866626_0_0_1"/>
    <dbReference type="OMA" id="TERIFQR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="137" mass="16197" checksum="3959D39AD924E38E" modified="2015-03-04" version="1">MDWSPVMDVKHRSDHKKVRRRQIPRNANVIRKKNAKYEIPPGETLENIDQLIAEAHGRGDKKAVIRLIGNKRLLRNRLAALESRERKKRYIEKLEKDNKQLSDELNSTKEDLDRALEKINHLERQAAHLKIVIEKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1B3</accession>
    <name>A0A0B1P1B3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002105">
        <property type="protein sequence ID" value="KHJ32407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1B3"/>
    <dbReference type="STRING" id="52586.A0A0B1P1B3"/>
    <dbReference type="HOGENOM" id="CLU_021483_0_0_1"/>
    <dbReference type="OMA" id="VWDKPDG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="572" mass="62128" checksum="64784A9B474539AD" modified="2015-03-04" version="1">MLRGNAYPTISYFNTSKTNIFTGKSRDGLYEPVLAESEREAVSDLLQFLENRGETDFFSGDPLRALSTLVFSDNVDLQRSASLTFAEITERDVREVGRDTLEPILFLLQSPDIEVQRAASAALGNLAVNTENKVAIVLMGGLTPLIRQMMSPNVEVQCNAVGCITNLATHEDNKAKIARSGALGPLTRLAKSKDMRVQRNATGALLNMTHSDENRQQLVNAGAIPVLVQLLSSSDVDVQYYCTTALSNIAVDANNRKKLAQNENRLVHSLVNLMDSTSPKVQCQAALALRNLASDEKYQLEIVRARGLPPLLRLLQSSYLPLILSAVACIRNISIHPNNESPIIDAGFLKPLVELLGSTDSEEIQCHAISTLRNLAASSDRNKALVLEAGAVQKCKQLILDVPLSVQSEMTAAIAVLALSDDLKTHLLSLGVFDVLIPLTNSESIEVQGNSAAALGNLSSKVDDYSIFVNDWDNPCGGIHGYLSRFLASGDATFQHIAIWTILQLLESEDKELIKLIGKSQEVVEMIKKISDTQVDSEGDGDIEEDGEGEVAQLASRSLQLLGQTKLSHIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1F9</accession>
    <name>A0A0B1P1F9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 6-phosphofructo-2-kinase fructose-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003683">
        <property type="protein sequence ID" value="KHJ30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1F9"/>
    <dbReference type="STRING" id="52586.A0A0B1P1F9"/>
    <dbReference type="HOGENOM" id="CLU_006383_0_2_1"/>
    <dbReference type="OMA" id="VKTHVFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="112"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="590" mass="66764" checksum="5BF2CA062C298779" modified="2015-03-04" version="1">MDSNIGNAIDAGSNLVVTPGTLSCHCLKTPGNDMVETPTRFSRPELAETYINALDLNRHSSEFLSDNDPNDADIHANSPKYMRRSSTLTDGIHDIREDRNNSLAPAQLYSTESGRLFHSGRIAIVLVGLPARGKTHISVSLARYLQWLGVKTRIFHLADYRRATMGEKKDLPDDYFFINACAKSVYLRQKILQKCREDLYAWLNDENGQVAIYDAVNPHANGRRSLAEEFAQRNVQTLFLESYVTDQRILAENARNVKIHSPDFHGMDADEAAQLYLRRINMKIPLFETMMENDLNYIKMINAGESIQYNNVSFGYLSLRIVFYLMNLHIKTRAIYFAREGSSSDEDSEKVDASLSEEGVKYSQKMTNALLKHREAEKATAIAEGESSATLRSLTIWASTRKLSFETAIPLKEKGFTVRQRSQMSQLNPGVCGKLNEASIRERYPEEVIKHAADPYHHRYPRAESYHDLAVRLEPVILELEREENDILIIAHESVLRVLYGYLMACDATFIPSIEFPRNFILEVVPTAYENEAKIIPIPDISSDKVFDHFSQKNIPTPKITISSLPGTGTSDSNPQNLTSRPEEHPLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1R5</accession>
    <name>A0A0B1P1R5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003650">
        <property type="protein sequence ID" value="KHJ30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1P1R5"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="54185" checksum="45853ABA9A9898ED" modified="2015-03-04" version="1">MTDSTDKSQESQALSTESSNQPPPIPSIPSLHNSPSPFASPTPPLILEPPTTTIDGRQIFKPVAPSKRPIIERPTPSCSNKINIENAFLPKEPAEIVAIRQHRERAWHARFMICTTAISSIESSLANFKDEIEVEEVAAFKAYLQLAIANFAAVDNSPIPPKIPSHSRPSKGSSHGLGVDKIAANKVATAIPRSYTGKKLKVRLAKISLQLXXXXXXXLPHEHEWRKLSPAGIREVIVKKLAISPALFGKIKPVHSGFALSPCSTEARETMLNAGNRLFLSGAKLEPATNWTSVIFPTVPATIRKEQGEVEVNKCMLTEEIERVCQIRPAHVKLYGGIKPGAPHRTWMAYFPTASRTSFRVFDESGIARKFKKQQPLEFCKRCNGHHPTKNCSRAPSCGNCGNCGGPHRSDSRRCFARPTRSGAPTKEQLKIYRQAGEREYQAVIRAKAAEELAASANTNNTELTSSQDSEVDNDIDNIPASSVDHPTVDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1V7</accession>
    <name>A0A0B1P1V7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001928">
        <property type="protein sequence ID" value="KHJ32637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1V7"/>
    <dbReference type="STRING" id="52586.A0A0B1P1V7"/>
    <dbReference type="HOGENOM" id="CLU_385516_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="82839" checksum="40F15217DDDF609F" modified="2015-03-04" version="1">MAAFLWRTISKGYRDSLEKNISTRKQLHDVREICKFTIFQQEANLESQIEKLGKGPQGQSHDQWAQTWIGVLISSKEISNSIWTEQRIYREFVKISLTFLPAFGEKLKAKIIETDASKLKLNETVRQYSAWASFGIPQTRTSFKGVFATLDEKNKMLKLINRRVSKIVDQRILKAIKTIGKLPFVLVAKDIISTSASISMFHNLEIPIKVCTGDSNCFIIGTGSIRLAVNTDKGQRYLWIDNAQHISGFHINIIAYKAFKHGGAYLDGKKNWIPKVKDDRCVAICETSPCSSFLVLENKKSDLLLKTSFATNSSEQKVYTATAERWHLRLGHMSHENIHHVSQNVDGVKVTDMKKRDNTNEKNILYEVCNIAVSHTKISRLLQYKGETPFQWTHINLIHEEPGLSNERYIFHFYCQLTKFNIAYVTSDRKQKTLVNCFAQAHDLINKWGFYMQFIRVDQEAGLQSEFNDYCAKHSIWHEKTPTDIKEPNRATKRSGGWIITEALGYKTPFELVTKRRPDLSGYRIPGSKFYVTKKNIPALQKQATRSDIGYYIPNSSRDIRAYEMSHFSWENVRNLDITPVIEDRFVSIENGNPIDQPLEDVIEESPTFHNQADNENIHTNTNPLSESTDKTQTDFHGNLPTTRATPEISNEGTISRETSHEKVEDSENKKRPHNRRLTEVQVLEGLRETSREARARRRNQRKENLNFYLYRSYRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1W4</accession>
    <name>A0A0B1P1W4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative m protein repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001915">
        <property type="protein sequence ID" value="KHJ32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1W4"/>
    <dbReference type="STRING" id="52586.A0A0B1P1W4"/>
    <dbReference type="HOGENOM" id="CLU_708217_0_0_1"/>
    <dbReference type="OMA" id="HIAQADK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="390" mass="44316" checksum="E2804CEF077C4C5F" modified="2015-03-04" version="1">MDDQAKAQKLAAAKRRVEQLKKKKGNVKKEIDPLEASVKSSAQNLPDSFETLLTNETTTTEEAKNYEEDKINEVTSTKDIEQHAITSIELKSNSPSSQNQSTLELMSPVNHKISTSDLALDEEKHRDDFEWEDKMDKKRILDSKEINPPKLAESSDSFETEGIDVTNLQIEYRSQLVALDNQKAEAEKKCHQLCARIVELEAENQNLRQELNRLSSCNDQNMVDKGLDQISQESSARFLVKIKELEDEISELRRGFHSSPKSILNHEDSPGTSSLGVKFIDVDLGAYSSQRRDSSFTGKTGLGKLISNSLNAITGTNNGYNEYRAPDEDELIDFDEDAFRLAKEEESKNRIERIKNIKRNLKEWEGWRLNLVDVRNKYRDSSGASPIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1X4</accession>
    <name>A0A0B1P1X4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003028">
        <property type="protein sequence ID" value="KHJ31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1X4"/>
    <dbReference type="STRING" id="52586.A0A0B1P1X4"/>
    <dbReference type="HOGENOM" id="CLU_071125_1_0_1"/>
    <dbReference type="OMA" id="GSGPWFY"/>
    <dbReference type="OrthoDB" id="2349272at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058824" description="Transglycosylase SLT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23320" checksum="BD3C8B043C2E08ED" modified="2015-03-04" version="1">MRSELFKAFLSSLVCVYATPVPTQRGLVQITPEQILKIAPSSNSCPSPPGECATNTQAAPFLNEAMSKYQISSLGEKASILALIAFESGDFKYNTNHFPAPGRPGQGTRNMQTAPFNLQYVKSIPELASKNTHTSVDGLSPSELNEIRALVLPDKYSWASAAWYLTSQTTCSSARKYLQTGSDEGFNAHMKCVGISSVGSDRLSYWQAAKTALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1Z0</accession>
    <name>A0A0B1P1Z0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003016">
        <property type="protein sequence ID" value="KHJ31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1Z0"/>
    <dbReference type="STRING" id="52586.A0A0B1P1Z0"/>
    <dbReference type="HOGENOM" id="CLU_005966_1_0_1"/>
    <dbReference type="OMA" id="ARCADHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="165"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="317"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="483"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="694"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="877" mass="98494" checksum="AD65EB7AB12E8802" modified="2015-03-04" version="1">MPVNQAKVKSVQSGDSLVLTAIGNPKSERILHLAYCASPHFRKEGEESWAYESRDALRQLVVGKVIQFNILYTIPSSKREYGLVSLQDGTRLPEKMLELGWVKLRDDAGKKEDSAEIQQHIEILRAIEAKARSEHLGMFQNDSKQIDVKHDLGNPGLFLENWKGKSIDGLVERVLSGDRLLLRLLLSPTEHIQVITLVAGIRAPNTDRINSSTNQLVSGEEYGNEAKDFVEERLLQRTVKVDILGLSPQNLLIASIRHPRGSIAKFLLEAGLARCADFHSTLLGTEMAPLREAEKKAQLAKSGLYKSYVAKNVNLSGNVEAQVTRILSADIIFVRDRAGVEKRISLSSIRGPRPTDPAESPFRDEAKEFLRKRLIGKNIRMSIDGSRPATDEYNSKDVATVTLNNKNIGLIMVQEGWASVIRHRRDDTDRAPNYDELLTAQEKAKEDKKGMWSGSSSKAKQFVDVSETLQKAKFQIAALQRQKKIPAVVDYVKSGSRFVILIPRENIKLNLVLCGIRAPRSARNPTEKSEPFGQEAHDLAIKRLTQRDVEINVHSLDKVGGFIGELFINKESFSKILVEEGYAAVHEYSAEQTGNSSELIAAQRRAQESRKGIWTDWDPLKDIDHEKTSPVNGNEPVIIQREKDYRDVMITHISENCNLKLQIIGTGTAALETMMSQFRSFHSNPANSKGLPGPPKTGDYVAAKFSADGQWYRARIRSNDRVTKEAEVVYIDYGNSEKIPWSSLRPLSQEQFSPQKLRPQARDAILSLLQFPSVKDYLLDAVHYLSDITEGKQLVSNIDYTSPDGILYITLFDPNYSEKLTDSINTEMVAAGHAMVPTKLKAWERSFGDVLKTLREKEEEAIQSRRGLWEYGDLRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P226</accession>
    <name>A0A0B1P226_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative tricarboxylate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002953">
        <property type="protein sequence ID" value="KHJ31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P226"/>
    <dbReference type="STRING" id="52586.A0A0B1P226"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OMA" id="AWYAGCT"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="101"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="295" mass="32119" checksum="0D0EB46567C363FA" modified="2015-03-04" version="1">MASAQAKKEMPTPLRSILAGSTAGAIEIAITYPAEFAKTRIQLNRRLKDSAKLPWPPFGKIWYAGCTTLIIGNSLKAGIRFVAFDQYKALLQDPNGNISGARTVMAGFGAGVTESLLAVTPFESIKTTLIDDRKNPRPRMRGFLDAVPIIARERGISGFFQGFVPTTARQSANSAVRLGSYAFLRQLAQSFVAPGEKIGASSTFIIGGIAGFITVFATQPLDTIKTRMQGIEAKTMYKNSFSCAALIARKEGFLTFWSGAMPRLARLILSGGIVFTIYEKSIELMEKLDPEKEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P242</accession>
    <name>A0A0B1P242_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002182">
        <property type="protein sequence ID" value="KHJ32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P242"/>
    <dbReference type="SMR" id="A0A0B1P242"/>
    <dbReference type="STRING" id="52586.A0A0B1P242"/>
    <dbReference type="HOGENOM" id="CLU_001485_21_1_1"/>
    <dbReference type="OMA" id="VYNVNRH"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070463">
        <property type="term" value="F:tubulin-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099606">
        <property type="term" value="P:microtubule plus-end directed mitotic chromosome migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007079">
        <property type="term" value="P:mitotic chromosome movement towards spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031115">
        <property type="term" value="P:negative regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070462">
        <property type="term" value="P:plus-end specific microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="10"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="751" mass="83877" checksum="430D6B5C73BB2FCE" modified="2015-03-04" version="1">MGAPDPGASSISVTVRVRPFTINEAAQITKREEGVLFLGDGSLAGAPTPKLGQKGIRPVVKVIDDKCLVFDPPEDNPVTRFSRSVVSNMGKRVKDQTFAFDRVFDENTTQAEVYESTARELLDSVLDGYNATVFAYGATGCGKTHTITGTAQQPGIIFLTMQELFEKIAERNDEKQTDVSLSYLEIYNETIRDLLVPGGSKQGLMLREDANQAVSVAGLSSHHPRDVQQVMDMIVTGNEFRTVSPTAANATSSRSHAVLQINVAQKDRNADVSEPHTMATLSIIDLAGSERASATKNRGDRLLEGANINKSLLALGSCINALCDPRKKNHVPYRNSKLTRLLKFSLGGNCKTVMIVCVSPSSAHFDETQNTLRYANRAKNIQTKVTRNVFNVNRHVKDFLVKIDEQMAMINDLKAQQKDLETLAFSKFKKQCEKRESIMREGITRIRAAYDHSSGERTEKINNAKRLRQIERRICLLSAWVDAFEHICASREKEMAPNLDLMRKTVSGILVELESSRQHFHQLIEKTNWERAVDSACQNSIRLLNDAENSCESLEVSNLNREAALLKANAERDAQTELFELEKNFDKCEIQSLLTAQIEIISSLDDFLNMSEEQAISHARSLLERLLENCTVTVSNLIKPDGSIKIGQTVQPLRRGTPKRKKNLLLSNNNVVSAPVMQALAAVAPQVYLSPIKSSPRRKKLVYGKKNIHFSPKRKSSSKRTVRWRDDIESGILAEFEKTPHKPDLCWNITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2E7</accession>
    <name>A0A0B1P2E7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003613">
        <property type="protein sequence ID" value="KHJ30794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2E7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2E7"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="675" mass="73798" checksum="E839BB68A648E1B2" modified="2015-03-04" version="1">MLSSRQSLLRASSIASRSLRNARFSVTPSFVRQYAEEADKKVRGPVIGIDLGTTNSAVAVMEGQTARIIENSEGARTTPSIVAFTQEGERLVGVSAKRQAVVNPENTLFATKRLIGRKFSDIEVQRDLKEVPYKIVQHTNGDAWVSARGEKYSPSQVGGFILQKMKETAEAYFTKPVKNAVVTVPAYFNDSQRQATKDAGQIAGLSVLRVVNEPTAAALAYGLEKDEDKVIAVYDLGGGTFDISVLEIQKGVFEVKSTNGDTHLGGEDFDILLVRHLVQQFKKDSGIDLSNDRMAIQRIREAAEKAKIELSSALQTDINLPFITADSSGPKHINMKLSRSQLEKLVEPLIARTVEPVRKALKDAGLTANDIQEVILVGGMTRMPKVVESVKSIFGREPAKSVNPDEAVAMGAAIQGGVLAGNVTDVLLLDVTPLSLGIETLGGVFSRLINRNTTIPTKKSQVFSTAADFQTAVEIKVYQGERELVRDNKLLGNFQLTGIPPAHRGVPQVEVTFDIDADAIVHVHAKDKSTNRDQSITIASGSGLSDDEIQSMINDSERYAEQDKERKATIEAANRSDTVLNDTERSLNEHSDKLDKVEADQIREKITALRELVTKSQAGEETISSAQLKEKTDELQMASLNMFDKIHKATKESPSPPKENESKSSEDESKNEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2I2</accession>
    <name>A0A0B1P2I2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002800">
        <property type="protein sequence ID" value="KHJ31550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2I2"/>
    <dbReference type="HOGENOM" id="CLU_036943_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="184" mass="20276" checksum="A837BD19DE6F3ABD" modified="2015-03-04" version="1">MTILKNLEIHHPGIGADFLALLADGASRAMGGERVYCSVSKSVPSFNQSSKDKWAEKANFYLPSQGQSKEDRRVMIRLNPDHEARKSGSFELRQTMQKLVPDSSLVTDAWIALSGIAVLAPTPAKAAAILQAKKEAWTTFVIGPIQKMKKSLDGFCDPVDGLLQEDLAHINDVVPMREMGWARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2P4</accession>
    <name>A0A0B1P2P4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003144">
        <property type="protein sequence ID" value="KHJ31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2P4"/>
    <dbReference type="HOGENOM" id="CLU_880540_0_0_1"/>
    <dbReference type="OrthoDB" id="3593599at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="316" mass="36469" checksum="6889110CED2BB331" modified="2015-03-04" version="1">MISVIKYKVKTEPTEKQKTVELSSLNNSTTMRRSIQNEVPKSGKNEKKNDHRGSLASSSPPANQIEPIHLSTSKTAPAFMVDIPHPEIKLPPSIMKALLISHRKDIFDEYDTTTRQQSIIITQVLPDASAVFCIREALHFGERYIFDYIMYIGYQSPPAVIDPLQYAIGLVRGTPNSWIFNIGNPIVKNRTKGELLGFPEYACQNQVIKKKGTRGRFQGDLMRWEFKADLGIEGPLSKFVWTGTRKNRKLVELELRERQASKRVLAVWRSIQNQDPYRGRLWLRKNYIECRQDASLENVERRWAVAVWLTWRVLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2R3</accession>
    <name>A0A0B1P2R3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g1143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003122">
        <property type="protein sequence ID" value="KHJ31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2R3"/>
    <dbReference type="STRING" id="52586.A0A0B1P2R3"/>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="125" mass="14201" checksum="D3994119F8410C3B" modified="2015-03-04" version="1">MSSFTNKKSGGKSQRSAISDVVSREYTINLHRRLHGVTFKKRAPRAIKEIKAFATKSMGTLDVRLDPQLNKKVWEAGIKGVPFRLRVRISRKRNDEEGAKEKLYSYVQAVNVKDAKGLQTILVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2Z9</accession>
    <name>A0A0B1P2Z9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001640">
        <property type="protein sequence ID" value="KHJ33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2Z9"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="177" mass="19708" checksum="E67B7426B1808A28" modified="2015-03-04" version="1">MDHCSLIERPILKPTAPSKRPLPDRISKNSSENTGSVNAFLPKELAEIIATRQRRERAWHVRFMICATILSNIDSTLANLDEDIEKEEAEAFKAYLRLAISNFAAADFSPTPPRVPIHTRPNKGNGNVKGKEIDRNLTKKVAVATPRIILTQVPSREINKNAELPKLPNLVTTPGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P312</accession>
    <name>A0A0B1P312_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2748</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01003288">
        <property type="protein sequence ID" value="KHJ31069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P312"/>
    <dbReference type="STRING" id="52586.A0A0B1P312"/>
    <dbReference type="HOGENOM" id="CLU_031625_2_0_1"/>
    <dbReference type="OMA" id="GSYEGWK"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ31069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="218" mass="24271" checksum="0B3E47D8F8A7CA0D" modified="2015-03-04" version="1">MSKAEIYALPSLPYAYDALEPHISGQIMKLHHTKHHQTYVTNLKNTLETLSKATSSLDLISQLHLQAALSFNGGGHINHTLFWENLAPASSTSAQPNSAPELVNAITARWKSLDFFKESFTTVLLGIKGSGWGWLVQNEQSGSLDIITTKDQEVVPAGLKPLLGIDFWEHAYYLQYLNDKASYAKGIWNVINWVKVQERLLSSSNSIYGGLTELRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P362</accession>
    <name>A0A0B1P362_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002971">
        <property type="protein sequence ID" value="KHJ31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P362"/>
    <dbReference type="HOGENOM" id="CLU_049841_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="322" mass="36313" checksum="EA2BC3883DB14FBA" modified="2015-03-04" version="1">MTLKKNLQDDSFLQNKLLTACQTHPACLIGCSMPATSTNILINNLRLSINNHVAVSRSQEQSQFNQSSDVNTNENNQNYFIDRRYHSNPSYNRNQFSRQNGFSRNKSKRCFICRKEGCWSTRHTADERNKAKSKFDEKFRKSADRRFDQYVAEFEGNPGATSDNSDNDIEALVTEIENFELNDTEMFLTEVGAINKADATLIVNQLFNRSATHALLKNLDNNEEVTITTNPTASFLLESRYGCEMFYGIMIDTGAAGKSTAGYNQYLAYCHLFGKTYIDRSNEGAVNATFGIGSTISIGSITINTPIGECTFHILKTRDRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P367</accession>
    <name>A0A0B1P367_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chorismate synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001862">
        <property type="protein sequence ID" value="KHJ32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P367"/>
    <dbReference type="STRING" id="52586.A0A0B1P367"/>
    <dbReference type="HOGENOM" id="CLU_044758_1_0_1"/>
    <dbReference type="OMA" id="YFYYALP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="373" mass="42520" checksum="1CD6BB60AD574BA9" modified="2015-03-04" version="1">MTLIIFHFDKLVSHFALKSFKTMYISWGNIKVLLTFFGPILLPKAISCFQALRRANSSALVRPVPPKVLRALLLLFAAILYFGLQAMPYFSPEEIISLTNSRLQTPNDVLFTRLSALRSTGLTDSDQILKSRFSSLKSRLLYLQYGPTTIIECTFCDPEDPKSYFYYSLPSILFPHLLNLAILGILTSRLFTGRDTSVWRTQVNFAVIGLCALDLYLTFSYSTQLSSPTRPLQKVSFFHWNIRIYRHLTIALLDIIFGGLIYLSSTHRAFFEQLTIPERINSLNSVVDDARSIVTAIGVIQNTIVRDEVLGYNSQQYWRGEGQMIREAMETNEVIESIKNALENRIDMETIVADADSYAQKILMPFYERVNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P375</accession>
    <name>A0A0B1P375_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P375"/>
    <dbReference type="STRING" id="52586.A0A0B1P375"/>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="OMA" id="GTHEYCD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="2"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="343" mass="38053" checksum="E63A8E01F3703C93" modified="2015-03-04" version="1">MLAEFHEAPSALLFNSGFDANTSLFACIPQKGDVIIYDAYIHASVHEGLKLSRATKKCSFNHNSLSHLRNLISDQIQLEPGLVDGSKSIFVAVEALYSMDGDMAPLREIIELVEKSFPQGNSYLIVDEAHSNGIYGENGRGLVHSLGLQGKIFARLHTFGKALACNGAVILCDNLVREYLINYAKPFIYTTSMSYPSLVAIKTVYTLMRQGTTQPLISHLKTLIDYLFDQLSLLSPFTTHPITKDVLLSIPLKIPLSPIFPLLTPNPYDLASHCQAAGYLVRAIMPPTVPIGTQRIRICLHSGNTFKEVDNLVHCILLWLEKQRKKEPSTQKSSERSMIKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P387</accession>
    <name>A0A0B1P387_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">EV44_g0461</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="JNVN01002605">
        <property type="protein sequence ID" value="KHJ31775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P387"/>
    <dbReference type="SMR" id="A0A0B1P387"/>
    <dbReference type="STRING" id="52586.A0A0B1P387"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="66"/>
            <end position="219"/>
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    </feature>
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        <location>
            <begin position="275"/>
            <end position="537"/>
        </location>
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        <location>
            <begin position="72"/>
            <end position="77"/>
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        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
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            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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        <location>
            <begin position="167"/>
            <end position="176"/>
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            <name>FMN</name>
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        </ligand>
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        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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        <location>
            <position position="294"/>
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        <ligand>
            <name>NADP(+)</name>
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        </ligand>
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            <begin position="450"/>
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        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        </ligand>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KHJ31775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="694" mass="78029" checksum="47FE5519099B8A5E" modified="2015-03-04" version="1">MAKLDAVDIIVLIILLAGSIAYFTKGIYWAVPKDPYALNSGSNDIHRKSRKTRDIVEKMAETGKNCVIFYGSQTGTAEDFATRLAKEGKARFGLETMAADLEDYDYENLDHFPEDKVAIFVLSTYGEGEPTDNAVDFYQFITGQPTDSFTLGKEHPLESFNFVAFGLGNNTYEHFNSMVRNVTAALESLGAQRIGKIGEGDDGAGTMEEDFLAWKDPMWAAVAEKLNLVEREAVYEPVFAVNESEVLTGDSHEVFLGEPNKMHLATFAKGPFNAQNPYIAPIVASRELFNDPHRNCLHLELDISDSNLDYQTGDHVAVWPTNSDRDVDQFLKITGLLSKRNTVINVKALDQTSRVPFPTPTTYDAVSRYYMEINAAVSRQFIATLAPFAPTDDVKTEMIKLGNDKDYFQIKVSSRYLNIAQVLEDISGGREWNRIPFSAFIEGLNKLQPRYYSISSSSLVEKKKISITAVVESLEIPGRPTALKGVTTNYLLALKREQSGESFSDTHFLTYQVKGPRNKYDGFRIPIHIRHSNFKLPSDPSKPIIMVGPGTGVAPFRGFIRERAAKAKSRINVGNSLLFFGCRRQTEDFLYKDEWEEYKRDLGDKFTLVTAFSRESTPKAYVQDRLLEHAQVVNQLLLSKAYFYVCGDAANMAKAVLSTLHKVLSEQRNISEEKAEEIVKNMRALNQYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3E4</accession>
    <name>A0A0B1P3E4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001565">
        <property type="protein sequence ID" value="KHJ33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3E4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3E4"/>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21908" checksum="B36D856318BE0CA9" modified="2015-03-04" version="1">MPAYNSIFNEDSSHQTTQNIGKFPLLPLRTRVRGPAFTLPLCDLPAHLSPDPNDESYDVLDEVLSLFRANTFFRNFEIQGPADRLLVYGILWISECLSKIRGSMNVREAQKEIQNIALDVNFSIPGDPSFPLNQLFNSPSSPQEAETLRQYLCQLRQELASRLLARIYAEGPDKPSKWWLSFSKRKFMGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3I3</accession>
    <name>A0A0B1P3I3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003105">
        <property type="protein sequence ID" value="KHJ31229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3I3"/>
    <dbReference type="HOGENOM" id="CLU_797390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="348" mass="39835" checksum="9B5E5853D633D1B9" modified="2015-03-04" version="1">MPNSSNQGEAFEKLPLGSLPQEEEEEKYEDEVKEEFDIDNTTGIKSVKGALVFMQQGLKAHAIKTDEKLNQFRNILRIQSNATTEAMREFKNLINAQNTESKGKSRNNSFKNHHDTEKLKEDNDSNQENYLAALSATIKRLEAKIDSLEITRPSGLNKVKKLAPDNMPGPRRPNNLLNCQDLRPENLSGADTPTFEIYIKSIWPEALSSGEVNEELRLSKNATHKFSCMEELKDASADNWQRLHNIQRSLFNEMTPYRFWPSRIVGNLSGDFDTVAKFIRYKNPSWLLTIEAVLTIMRNYNGVQPPISQLASIRKKSDEGDLQFLRRVRSVFNRMCWNSRLQALVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3V4</accession>
    <name>A0A0B1P3V4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001489">
        <property type="protein sequence ID" value="KHJ33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3V4"/>
    <dbReference type="HOGENOM" id="CLU_018153_7_1_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="10628" checksum="37BC35FA855AF77B" modified="2015-03-04" version="1">MASTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQLKNYRQAGEREFQALLRAKVAEESAAAADNSNSNVISSQDTDLDSNIDNSQASSVGNTMDGAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P479</accession>
    <name>A0A0B1P479_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002871">
        <property type="protein sequence ID" value="KHJ31469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P479"/>
    <dbReference type="HOGENOM" id="CLU_1442078_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="188" mass="21319" checksum="C05EBA26B8E42181" modified="2015-03-04" version="1">MVRMNNLQLESYMKGSVEDFEMKTVQLCKMLEESEKGSKEIKDSVKSNQDNLDSFKKVQIDQTKASQKIAENITESLLSLSRQFEASKQKSKKSEVKQLKAEKRLNLRLEIMQTSLSKQILEALSSNSNTSERTARELVRTSHDESRFRRSSLPPSKHGGSSSTNTSLQLADPQRSNLSILSPNHRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4E0</accession>
    <name>A0A0B1P4E0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phd-finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001602">
        <property type="protein sequence ID" value="KHJ33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4E0"/>
    <dbReference type="STRING" id="52586.A0A0B1P4E0"/>
    <dbReference type="HOGENOM" id="CLU_001648_0_0_1"/>
    <dbReference type="OMA" id="CYYFVPP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="799"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1195" mass="132437" checksum="EF8A6BC8F2EBAB35" modified="2015-03-04" version="1">MFGKVWKIPIIVFPTTIYWRLSFSITESAPWQKYISNILHACRIVQGHTLDSRVVVATAKKGKANDTRAMSNLSTRPTRLRVSNHLVPVSNVVSTESLESAASCSRLSKPFLDGWVEPVVPPPRPSYADAGIERHGVVQNMAPLGSRPSMKILKAATLLDGTESIPRLARSRNTEISKLSIPVRSNDTQEPVEALSSNNFLKSQESQREKVPADDFTEERCSNSSVSEEQASCSKSLSVSTPISQNLGHSAVDINQVTNSTDTNTSDSETFKREFSQSSIVPPALGKDGLPLINIALTDRVVELAIQNAIERKRWPTAYALRTLYDDNRGDITFVRLLEAVYYNYATENDLDEFERLLKPKKFEGKKDRVGECYFSGSGSNTSTRRPIYSAIEAVNPPAPVYVTPYNSLPMSGSSSNVVKSSATRSKSLNILDMPKKQPSSTHALSISSDPGNAHEDLKINCFEKNCLEAVKITNFGTTKVVKGNSKSKSRSSSILSSSSLSSVDESLIDDVSISPIQSIANHGLATLGLFGTRPVFVSPYASANNFKEAASSAESEARNRVKPIVAPQNSRPKTHTFTVLSSNNIVSTDSNNPSKPLSKMVEVASAPEINLSERKRKSLSNYSKKRDSKVEVKNFSSYNYNDEKNIKKLKAREFTNSNTIAKVRESFERLSSQLPIDPNERESKSNNEQVITVIPNLPLRRPQQIRLNHNISQTKIQVPESLTNDQGCRAKITSNAPPVTLISTPMHTNKRNRPFNGLCVKSSLVKKKTGTFAGIPRSSNDHNSPIRNGNYGTYDDNDDFCAACGGNGEVVCCDGDTCRRSFHFKCVDPPIMPDALPETWFCNECRVKQTGHHEEKIGPFRLLLQQLEGKNPGAFSLPLNIRCYFENVKTGPEGEYEEIMIPKPKITNRSGWEETPDNFRKKDSKGKPILCHRCGLQAEAPDRFIIQCSFCNLYWHLDCLDIPLAKEPSAGRPWQCQAHIDDLLSLIPSSLGPAHRFRKIKGAPLIQHELSRGNKNHGHIEIDNDQLDDEADSQSTIYGERPFGRIAKISEQSIKLDFLLRVKKEGGGYTRARFSDARRKKKRSWSEANLCDQQAALNLTALANSDPSLKGIENLISALLIEAPPNVIKIIAQGDAENMISDHPQLSSTDINSLLALRNLINKKLGCLEKAETEQPFRKKLRTSKRASTSPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4L8</accession>
    <name>A0A0B1P4L8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EV44_g4675</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002722">
        <property type="protein sequence ID" value="KHJ31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4L8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4L8"/>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OMA" id="AHAQYMV"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="17">
        <location>
            <begin position="36"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="148"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="18">
        <location>
            <begin position="289"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="513"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KHJ31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="699" mass="78873" checksum="617CF9594F9038E0" modified="2015-03-04" version="1">MSTTPKWVQDLRPSSPQGSELLRAEREKSNLSIDNLSKFLFSADVLNRRQKILKILQAEKVFDKSHNYFDGRVDRFKTALARSKKLRQLEIQHKWTRQDLLDASDLISEPGPYGLHASMFLTTLRDQGTPEQHKLFLEPAQNYKYIGCYAQTELGHGSNVRGLETTATWNPEDRTFTLHSPHLTSSKWWIGSLGRTANYAVVMAQLVIGGKPYGPHPFVCQVRDLNTHQPLDGIYVGDIGPKFGYNTMDNGFLLFNKVKIPHVNLLARFSGVDPDTSTYIRPASASLIYGTLTWVRSTIVLQSGGVLARGVTIALRYTAVRRQFQDRDTHAPAHGENQVLNYTMVQYRLLPLLAATFALHFTGKAMMNLYEISQKNLRQNMGKLADKKHGVGPEEAHPGTDLLSDLHATSCGLKALASSIAAEGLEVARRACGGHGYSSFAGISSWYADYLPTATWEGDNYMLTQQVARYLLKSARAVLSGKSNNNDTSKILRRFLDKQDTGAAHDILSVDSDIVAAFAWRTAYLTFEALKHRDVEKKSWNSLLVDFWRLSTAHSQYLVVKNFYEVLQSTSIEYELDQNTLIVLHAVFRLFALHTLEREASEFFSSGAVTIRQIQLTRAKAVIQLLEHIRPHAIKLVDSWQFPDWQLDSSLGRYDGNVYEDMFHRASELNPLNCLIVDPYPENDTIVKKIDKTAFKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Z8</accession>
    <name>A0A0B1P4Z8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ulp1 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001504">
        <property type="protein sequence ID" value="KHJ33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Z8"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Z8"/>
    <dbReference type="HOGENOM" id="CLU_043678_1_3_1"/>
    <dbReference type="OMA" id="SFMLMQT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="21035" checksum="7BF274540C049D65" modified="2015-03-04" version="1">MAFMLMQTPNPLTVKDALPDFSQTTHVFLPINDARSVTLAEGGSHWSLLLVSIIDGTAFHYDSLMPSNYNEARLATNKLSILIGRNLQFVNLDDSPQQENSNDCGIYVCIQMRYLLLKRILSANSHEKVSMSLGGKLVDANGGRKEILKTIEGYRKEGGKRRNKQDEHHSSLSFGKRKSNSGSPPRIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P544</accession>
    <name>A0A0B1P544_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g1211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01002060">
        <property type="protein sequence ID" value="KHJ32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P544"/>
    <dbReference type="STRING" id="52586.A0A0B1P544"/>
    <dbReference type="HOGENOM" id="CLU_048602_1_2_1"/>
    <dbReference type="OMA" id="SCPVDHK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="304" mass="34790" checksum="78C04ECE24058ED1" modified="2015-03-04" version="1">MSNNDETKSEACPVDSATRAAWLESRATNKPSLPLVDSLKDVTSKSLDKQCDSYTTTLSNTVKMAQATSLRSLWESLTTWPPPPEERGINSERNNYNHTINHIQGPERKATKISLGVDREISTIPRTQSQKLDDGGRDEAKQLLANCERESGMSPEGNWIYPSEKMFFDAMRRKGYSSEVRDMKTIVPIHNAVNEQAWKEIKQWEKPWLNEKCDGPKLHSFKGLPSSMTPKARLNTWLGYTAPFDRHDWLVDRCGKRVEYVIDFYVGRDQQKGDGKLNFYLDVRPKLNTLEGWKMRASRIFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P562</accession>
    <name>A0A0B1P562_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nuclear transport factor 2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001231">
        <property type="protein sequence ID" value="KHJ33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P562"/>
    <dbReference type="STRING" id="52586.A0A0B1P562"/>
    <dbReference type="HOGENOM" id="CLU_112120_1_0_1"/>
    <dbReference type="OMA" id="VPNWDAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019488">
        <property type="entry name" value="Nucl_pore_RNA_shuttling_Mtr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10429">
        <property type="entry name" value="Mtr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="169" mass="18735" checksum="B33B2B9B3D90E62D" modified="2015-03-04" version="1">MATLSEDVKVKAATSTAQDFIETYYPALNSSKGRSALASFYIKSENTKPDIIINGNTISSPTDFQKLFETQVQRAQYEVQSYDAHILNSNYNLLGYSNSSLSDKDGKRASVIVLISGSVKYWKEGEEANLRGFTESVVLVPDPEAIGPKSTKIKPRKWLIASQNFRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P570</accession>
    <name>A0A0B1P570_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002035">
        <property type="protein sequence ID" value="KHJ32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P570"/>
    <dbReference type="STRING" id="52586.A0A0B1P570"/>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="476" mass="52093" checksum="B9B8E572EB8A4469" modified="2015-03-04" version="1">MSGLRFLDLIKPFSPILPEVQQPETKVPFNQKLMWTGLTLLIFLVMSQIPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDINLDLKSDRELYQTAQKLFAIILSMGQATVYVFTGLYGQPSDLGAGVVFLLILQLVVAGLIVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTLNTGRGPEFEGAVIALVHLLFTWPNKQRALQEAFYRQNLPNILNLLATLVVFAAVIYLQGFRVEIPVKSSRQRGSRGSYPVRLFYTSNMPIMLQSALSSNVFLISQMLYSRFSENLLVKLVGTWEPKEGSSQLFAVSGLSYYMSPPFSFTEALLDPIHTAVYIAYMLIACAVFSKTWIEVSGSSPRDVAKQLRDQGLVMAGHREQSMYRELKRIIPTAAAFGGACIGGLSVASDLLGALGSGTGILLAVTIIYGYFEIAAKEGDMAGMNGMIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P587</accession>
    <name>A0A0B1P587_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002019">
        <property type="protein sequence ID" value="KHJ32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P587"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_1_1"/>
    <dbReference type="OMA" id="ARTKLEY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="333" mass="36240" checksum="B07792219EB48F01" modified="2015-03-04" version="1">MPAVRTKRQFTMAVIAKSRAKARLKNKRLAPDLIDINAFESAINDNASPGIEMIDEEIDRLIAKGLEASCWANTPTSSSTSSSISVDTPKPADQTKSTPTPPCSARLINPISKEPIVIDLSTSQENSRTPATNTPQEIPVTTVRKLPCPPELQEVVKVEERRAAQMAANLEVCTVAINGVEDALAHLTSGTRNDFVVSLKVYLKNAIAQFMRSGTSAIPPSLPCRPTGPLPAVPAMKNTARSTPTNKASIYHPAKNQINKTWANIAQKGHQKSPNIINISQNHSTVKISEKIINKKSAPLGGDMRLFLRISKDHDWRLLAPCGVREVLCIHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5B6</accession>
    <name>A0A0B1P5B6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002547">
        <property type="protein sequence ID" value="KHJ31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5B6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5B6"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_2_1"/>
    <dbReference type="OMA" id="EDASHQM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ31829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="20974" checksum="5A9FC344DAEA8765" modified="2015-03-04" version="1">MLALKHLIRYVSRTKSASLFFSSQGTPNLTASSDSSWGSITSSKGTSGILFLINNTPIAWWSNKQTVTAQSTCEAEYAALSKLAVAAQWIKPLYEELFLINSSPIVTEIDNTAALITANSTKIPARNRHFLMREETVRETVKNNIIKLKYTPTNDCKADGLTKALQRLKHNTFCTQIKLDLKHTALRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5E2</accession>
    <name>A0A0B1P5E2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative btb poz domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001994">
        <property type="protein sequence ID" value="KHJ32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5E2"/>
    <dbReference type="STRING" id="52586.A0A0B1P5E2"/>
    <dbReference type="HOGENOM" id="CLU_1020120_0_0_1"/>
    <dbReference type="OMA" id="PCQFHIH"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="273" mass="30842" checksum="05AC9A98EE1F35B2" modified="2015-03-04" version="1">MDASIVTDESKAIVETDAASMKDDVMPMPAPSVPSDYQTLALTTTNITSQDDRLISDDMGSEVVQLLVGADKKLFTIHRDLLLATGDAFVKAFDPKKNTKGRITMSSKNPDVLKLFIDFIYTRHVPGITTSMSENSKIFRIRNLCQLYVFAEELDLQTVIRNQILDQIQDGFLLLDRFPDASLILSIYRNTSIMSQLRKFVAACLIYQVRSLKIEIEAITELFKSNEDVIKDFLAMVHDFVPGQDPRIRNFEGHQDSPKCNNQSNIIERSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5W6</accession>
    <name>A0A0B1P5W6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001296">
        <property type="protein sequence ID" value="KHJ33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5W6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5W6"/>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="360" mass="40049" checksum="B91A164525FA3914" modified="2015-03-04" version="1">MAGFTFSFSGDDIDENLLTEDGSDSQLLSPQNIALERNRRMTTSAFPIAGQDTLKPQVHSLNAMLRDLPSRISYKTLTINCENGTQVVIPRRELWDIRVQLMAEDDDENLKNLGQSDIKTGIYEGGFKSWESSSDLVKVLYQGNLNQSMCSRSVLELGCGTAFPSLFEFQRQLQQSQTSGTVGNLSIGLADYNPTVLRLVTLPNFILSWAQEFRGMLKDEGELEIDESLVEDFKCSIKSCQMTLSFFSGGWSPEFVRLVSENMDINVFYFIVVGAETIYSPFALKSFTEVILSLLMSSNGNNKFALVAAKTFYFGVGGTMEDFCEQVKIHNGAIRLICEERVGVARAVVEVRLVSSNDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P601</accession>
    <name>A0A0B1P601_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">EV44_g1842</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="JNVN01002332">
        <property type="protein sequence ID" value="KHJ32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P601"/>
    <dbReference type="STRING" id="52586.A0A0B1P601"/>
    <dbReference type="HOGENOM" id="CLU_030279_0_0_1"/>
    <dbReference type="OMA" id="KQTVNWP"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KHJ32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="54964" checksum="AAAA983379939B92" modified="2015-03-04" version="1">MKARPIISHQRPIIISLAANKCFINNSCSIPLDLRRYFASSEKRGGLITKYTLNKKYSTKVSNSSHQDTTSSREENPNLPISQASGPPLADIIIDDKLQEILRRTLWHFRAPIRYAFAYGSGVFPQSNQKLSSPDHRPKYFNASATVNNALASAPKMIDFIFGVSHTQHWHSLNLAQHRDHYSALGSLGSGAVSMVQEKLGAGVYFNPYVKVNGITIKYGVVNLDTLCTDLTNWTTLYLAGRLQKPVKILRDDPRVRSANQTNLISALRAALLLLPSEFTEYDLYTTISSISYIGDPRMNFPTENPRKVANIVGCNLPNFRKLYLPLIENLPNVCFKDFRNTGLDWISDPHINLRLIQDMDPVKRGNIVRRLPEAFRKKLYFQCQSKYKIPQIEFDTILEASNVGDEMQIKRYEGGSFEQKIASEPPENLRNELKNAIRRTVRWPSISQSFKGLLTAGVAKTWKYIGEKIRKNRLGRLDAETSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P691</accession>
    <name>A0A0B1P691_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002068">
        <property type="protein sequence ID" value="KHJ32461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P691"/>
    <dbReference type="HOGENOM" id="CLU_1442076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="188" mass="21842" checksum="175A35F7DBB502D5" modified="2015-03-04" version="1">MATKTLKGRRPSFGPTIYHEEDVHMREPSRLNSDDHGCDRFRRTASLNAHPIPSCANKDKYPLDQSDSASLPDLPNKPVFYETLSERRNTSDDDDYDRLGERYFQREKTNVFEGGKNYTEYGHNDPNYHRYTRRTQRFYSPPRHSSPARDVPLNGWSRIRHVLREPLSEFFGVFILVLFGNGQISGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G3</accession>
    <name>A0A0B1P6G3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g1838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="JNVN01001206">
        <property type="protein sequence ID" value="KHJ33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G3"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G3"/>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_1"/>
    <dbReference type="OMA" id="KFADDEW"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="525" mass="56653" checksum="1634F260ED3856C4" modified="2015-03-04" version="1">MTFTSRPAVQTATELIGNTPLVRLNKIPQSLGIEAEVYAKVEFLNAGGSVKDRIALRMIEEAEKSGRIKQGDTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKMSQEKVAVLRALGATIIRTPTQAAFDSPESHIGVANRLHNEIPNSHILDQYVNPDNPLAHEMGTAEEIWSQTNGRIKAIVAGAGTGGTVTGLSRGLKKHNPDIKVIAADPVGSILAVPETLNHKNANHAYKVEGIGYDFVPGVLDRESVDIWYKTEDRESFMFARRLIAEEGLLVGGSSGSAMAAMVKGVNELRLGKEDVVVVVLPDSIRSYLSKFADDDWLAANDLLSPLTNSPLSDSPRNAPITDIYCGATIRSLRLKPITTVLANTYCSEAIEIMREKGFDQLPVLSPNGKKLVGLVTLGNLLNWISRGRGSGNTLVSEVMFDFSHVSEVVTDSKGFGLQKLESNVSRGGYVDKTRGRRNFIEITMDTHLSALGKFFERNSAAIVTDKRSGGEGGLTKPVAIVTKVDLLTWLVKQAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6G8</accession>
    <name>A0A0B1P6G8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative ercc4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g6248</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000974">
        <property type="protein sequence ID" value="KHJ34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6G8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6G8"/>
    <dbReference type="HOGENOM" id="CLU_013160_1_0_1"/>
    <dbReference type="OMA" id="CPHVSAD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="392"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="272"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="708" mass="81173" checksum="F28FAC2E99CEACDE" modified="2015-03-04" version="1">MSNTIIDLCSSPEVGNNLSQKNTNETLLLRSSQRNEFLNPPSFDWYDVSPETSDREIANLRPAIANVTSLPIIPYNSEENEQLIGTQNEFIDLISDETDNTEIRFSPSSKSWLDVEQFDDKREVELDTNIDKNGLKKFLNGHSRNERNFVLDSSTLSDPFVSTPIKNQRSSSAPSVVCSRLSATTEKINSSSKFDTEFETKSTLLIREESPKPIVNNFTFNLGDARLSSSPSIISDQSYKRKEMKRKLTTVISDDEIDEAWITELVRETEKKKGKAKHSCLSKASNKSRRKKVTSLDMGRENGDVTISKSGSANLHAKEDAIKKNEEKLKQKEERRKRKEEKLELKEEKAKMKEAEKLLKIKEKEKISLKKEWENSLNKMNKLKSKVESTPEMIVDIPSCLDEKLADQVRLFLDGVKAKHSTYGNSNNIIKWRRKVQAEWDLVDNHWKPVDERIEDEKHVLYAVKCQELIELIGGLEGHDLNAFLLKLTMKFNDCKIIFLIEGLKSWLSKNKAIRDKDFTNNVRNQILNNGEPSSQSTNPRKQRTKQSHQSVYVDKNKIEDTLLRLHVAHNVLIHHTNNPHETAEWIMRFTQHISTIPYRKQFDTMNTANFCIETGQIDSGKDLKDTYILMLQQMHLVTPSIAWGIESRYGNVQALIRGLEEKGPLALEHCRKSANKNGAFTDTRIGQSISRRVYSVFLGEDAWNAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6J1</accession>
    <name>A0A0B1P6J1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002213">
        <property type="protein sequence ID" value="KHJ32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6J1"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_1_1"/>
    <dbReference type="OMA" id="MEAEERW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="178" mass="19933" checksum="8F986F4D728806BD" modified="2015-03-04" version="1">MICTIVISYLDSSLVNFTNEIEKEEVAAFKAYLRQAIANFAAADSSPSPPQVPIHTRPKKGSGKGIDKNLKIKTTVATPRIILSRAVNREMNNKVDPLKIPQASDKTWMVVARKGHKNARIVNNNQTQVVAGNKNAPKPFNKNNSFTPFSDKRLFVRFPQEHEWRKLSPAGIREVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L2</accession>
    <name>A0A0B1P6L2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitochondrial distribution and morphology protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001965">
        <property type="protein sequence ID" value="KHJ32591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L2"/>
    <dbReference type="HOGENOM" id="CLU_016236_2_1_1"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ32591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="734" mass="84848" checksum="BE1D3CBE815E76EC" modified="2015-03-04" version="1">MLCKHILKTCDQLTASDSPYAVKHHGSTRMSRKIASKMWPYSRLTDNSLNYLLLWPPRSRILEAASLNPNRVFARSQYIPKSKPRVFSNKNISQIFLNHDHLNCSVSNFKFSIRRPWVTSLLDSSRSVSIPYRSTTCFESHRKITRNIHASSCQRSVKENEDKITVDLTTSKSTIRDEDKYIKYEKVGFKDEVNTYFRSQIPKISHRPTKEELLSAATGFWSRLKVRFKWFSIRSVRPWNVDDWSAFVSWFVVGNIVWILVGTTTFFSLVILSINTVVAQETLARWIGDYLTHSSGIKVVFESAVVPKWKDGVITFHNVFISRRPGQGKTKVRKGSSVNAAAEAAAERQNDIDNKKEEEDTNYTQFDLTIATINVTLSFVKWWNGRGLLRDVEVKGVRGVVDRTFVTYSRERVDPQIYLRQRRPGDFEIDSFRLDDLLVTVYQPNGFRPFPVRIFFCDLPKLRKQWLFYDILSADHMSGAYDESLFTIHPHQIYGFAGFKQDEMWDLDKNQWKKHSRLRIDGLNIDHLNRGVAGPFGWIYEGNIDIVADILFPADTDESISKVMSDFYDRMEATVNAHRNQVHTNENTLETIEAISSWESEKHTQKLKDKEDRRFLVMELKLHLNEVKAAVPLFTRDLSYVNQTLIRPIVAYINNRRTFIPISCRIVKDASDFNGSWTIFDSGLMDNLSAETYEAFSKDVVDRQARMRRLKKLGLWSISLAVQALFMGLAGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P1</accession>
    <name>A0A0B1P6P1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative auxin efflux carrier superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001139">
        <property type="protein sequence ID" value="KHJ33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P1"/>
    <dbReference type="STRING" id="52586.A0A0B1P6P1"/>
    <dbReference type="HOGENOM" id="CLU_026460_1_0_1"/>
    <dbReference type="OMA" id="WSWGYHI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="568" mass="63232" checksum="C8C23101D1025D2E" modified="2015-03-04" version="1">MTFPTRLFSLQASSDFQPLIMPSITQYNITHQLNTAMNSHVSLGHLILLIFEASMEVVCVSLPGYILARLGLFNAEHQKFVANLNVMIFTPCLIFTKLASKLTAEKLLDLSIIPVVFLVQTAVSYLVSITVAKCFGFGKKPTNFVTAMGIFGNSNSLPISLVISLSKTLNGLHWSKIPNDNDEEVAARGILYLLIFQQLGQLVRWSWGYHVLLAPERINVVERGNNIEEYSEPPQLYSRLDSRPAHLQINEGCEASETASLRSDNKIVTTKSICTGLSDSEDDSHTMTETYPCFLRRDTPTYNEISSLITSFPRIQTTPTSENQNIPSGLKGVVPLVRIHIYRFIHFIKQKIISGFCFIFTSLPGSLQIFLWKTYSYTKRFLAGAWEFMNPPLWAMLSAIIVASIPTLQHLIFSQGTFISNSFTRAVSQSGGVAVPLILVVLGANLARNTLPHESRDKYSEENQIGKKLLIASLLSRMLFPALIMSPLLALIAKFIPISIVDDPIFVIVCFLLTGAPSAIQLAQICQINGVYENVMSNLLFHSYVIWIFPSTLILVTCALEVVRWASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6W0</accession>
    <name>A0A0B1P6W0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative blumeria specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g1924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002115">
        <property type="protein sequence ID" value="KHJ32389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6W0"/>
    <dbReference type="HOGENOM" id="CLU_1255786_0_0_1"/>
    <dbReference type="OMA" id="PRDIGIC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="27854" checksum="ADC981DD2A272ED0" modified="2015-03-04" version="1">MYISPKTMTKIPHWPIVNFPTHEIYARFAPGTLDTIKQIRNKYTTNLIYPRDIGICLFRGITKNVTTTKTLHGKLTTIASSVAPFQVEVLRPFRNRSAEERNYPASVYYEISNSPFNLLCIDLIILFKKHFTQYLPRPQINKSFKIGITGEVKSYEESDKIVTELKTIEKPNPLLFDAFVLASRPNQNLLSRLDDEIQEFPFTANKETFELYLQNLKAKRDVFFRKKLEKNQQNGGEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7B0</accession>
    <name>A0A0B1P7B0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000800">
        <property type="protein sequence ID" value="KHJ34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7B0"/>
    <dbReference type="HOGENOM" id="CLU_2814337_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="67" mass="7153" checksum="CF539BF3ACC6B191" modified="2015-03-04" version="1">MDDPSNSSEFGDADMEDPSGKAQSEATETVAGEENEKTKIEARGIDVGSQSERLGGRNYIDANSWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7F6</accession>
    <name>A0A0B1P7F6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01001953">
        <property type="protein sequence ID" value="KHJ32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7F6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7F6"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OMA" id="YHYLRWA"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="44"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="597" mass="68401" checksum="154A51A3F269CF7C" modified="2015-03-04" version="1">MIGRFQLRPRSINLLCKNSIKFRRNSIVSRNRKPQSLRERGPARTRFAPSPTGYVHLGSLRTALFNFLIAKATGGQFILRIEDTDQKRTVPDAIQRIYEDLKWAGIHWDEGPDSGGHFGPYQQSDRLQLYREHANKLIESGSAYRCYCTPTRIEALALTQAQQGSSKRYDRCCAHLNLEISNEKAARGDSHVVRLKAPDQYPSFSDLVYGFIKQKVKNVASNFFDDPILLKSDGFPTYHFASVIDDHFMQITDVIRGAEWMSSTHKHIAIYEAFGWEPPKFSHVGLLLDESRRKLSKRKASMEIASLRSEGVFPEALTNFVALLGWSHELQSDVMNMKELIENASMKFTKGDTVVNFNKLYFLQRRHAARYASAPQSDQPLQSLYHLAVIPIVKELNSRLTFEDFSTYSKLALGQPRCTYIQRILEADASNYTTPKDFILRNIYFFVPPSSKALTDSMSKKIKILGPSDEDKKENIKTLLVLFRTINEIDLEDWHMEVLRGRVNWIIEQRTNIISEGQKDKLENSSDIISRYQDIKKAWGKFVHQYLRWALCADKSGPDGITILFLLGKQNVAQRLQRAEEVVSARPEQSVEKLKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P838</accession>
    <name>A0A0B1P838_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P838"/>
    <dbReference type="STRING" id="52586.A0A0B1P838"/>
    <dbReference type="HOGENOM" id="CLU_001650_6_4_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="86" mass="9544" checksum="4220881FD7C25B49" modified="2015-03-04" version="1">MPAGPIPILEDNTGAIKWATDDAMTSGRRHVRIEYHYIVQEVRSKNIILRKVASEDNAADGFTKPLAVESFKQFIEKSGLKNGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C1</accession>
    <name>A0A0B1P8C1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gtp-binding protein ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001745">
        <property type="protein sequence ID" value="KHJ32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C1"/>
    <dbReference type="STRING" id="52586.A0A0B1P8C1"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_7_1"/>
    <dbReference type="OMA" id="IQQKNNC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="141" mass="15509" checksum="84DFA39E3FC18CA7" modified="2015-03-04" version="1">MWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDISDKKVVEYTVAKEFADSLGIPFLETSAKNANNVEQAFLTMARQIKERMGTTTANNKPTVQVGQGQGVQPGSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8H7</accession>
    <name>A0A0B1P8H7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8H7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8H7"/>
    <dbReference type="HOGENOM" id="CLU_131037_1_0_1"/>
    <dbReference type="OMA" id="MDFNCSK"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="97" mass="11137" checksum="8A5D86713A881738" modified="2015-03-04" version="1">MITKFLTEVKSVFNPFSVKAKPARLFLAFLPPSARRSMKIETKILPRESVEPSHLYLKFKDGLELNLKPDTLGLQGIFEEVDRHSRILLRKEELGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Z7</accession>
    <name>A0A0B1P8Z7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000491">
        <property type="protein sequence ID" value="KHJ35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Z7"/>
    <dbReference type="HOGENOM" id="CLU_036943_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="270" mass="30219" checksum="C6F42FFD926FD50A" modified="2015-03-04" version="1">MNLNAESESELESESEIEDVPLLPSIPSLKRSSELASPIDSIHAMTDNQNEDLPLQNSKLMKKARGPLALVGPFLEQMEIDYSRTAAGFLALISEGVSQLPRRPIPPQGQSHEDRRVMIRLNPEYEVRKIEPLLLRQQLQRMIPDPTLVADAILVSSGVAILAPKPAKAATILQYKEDVAQRFGNAVAERQESWTTFVIDPLPIYISNIEGPQDPIDELLLQELGFALIRDEAPIRQMAWTKRSKESTEPLGHIRKHVSKTKVHKFPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P996</accession>
    <name>A0A0B1P996_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g1397</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001145">
        <property type="protein sequence ID" value="KHJ33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P996"/>
    <dbReference type="STRING" id="52586.A0A0B1P996"/>
    <dbReference type="HOGENOM" id="CLU_625697_0_0_1"/>
    <dbReference type="OMA" id="TIQFHIP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="57"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="371" mass="41346" checksum="8464660DFE5C7A38" modified="2015-03-04" version="1">MSSSEIDHNFSRAHAIVNSSILPIVEKYAQHSIAVWEGSQFWKKIFEASANVSLSGVEEQNDHNENLTSVHSPENTAKYTTGLTSVSDDEKHYSAKEDESEPHDDADSFLGHTDFTQSTPRVSESDRTWKDTHHMEYGPSTENSKKDATYNLKNKADNYETTGHDSIIFDETKPPIAALCSPINDLLSLTQNRPGPDPLLHRVLDKNYRLQATPLAVTRKKNISSKISKWSDFELPDSSPLVSAPQLHADLFSSPTRPRNKLPVSRTPRVDDRTPVKTSPENSATKPSKNEISWESDSEEDAEGIYRELGMSPPKTIQFILPQSKILQTPAREASQRIVQDLLATAGVGFNASDTEDTSSLVVRNLIDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J4</accession>
    <name>A0A0B1P9J4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 60s ribosomal protein l35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g2053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001091">
        <property type="protein sequence ID" value="KHJ34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J4"/>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="127" mass="14562" checksum="361AA6EF41EB5F84" modified="2015-03-04" version="1">MSSSKVKAGQLWAKNKADLTKQLGELKTELGQLRTQKIAGGSASKLTKIHDIRKSIARVLTIINSKQRSQLRLFYKGKKYLPLDLRPKQTRAIRRRLTKHESSKILDKTAKRLTHFPQRKFAIKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9M8</accession>
    <name>A0A0B1P9M8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative j-type co-chaperone mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001492">
        <property type="protein sequence ID" value="KHJ33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9M8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9M8"/>
    <dbReference type="HOGENOM" id="CLU_068529_1_1_1"/>
    <dbReference type="OMA" id="TVELKYW"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="229" mass="25924" checksum="67C29759A2D9B2C2" modified="2015-03-04" version="1">MSWSAIHRLYYPPLSLAGLPAIIKTARSRLNFVNKTFITLQHSSSKPNLNNRPDGTYYDLFPKTFALGPPPTGTFNIDLVALRQEFLKLQAQAHPDRHANTSKESAGHESTLINEAFAVLKSPLSRAQYLLSLRQSNIKEEEINRSIAESDILSKVMNIRERIDAARSCSIATLGKLKNEIEQNVKQSETQVAKAFDNDDLQAAKRQTIFLQYWMSVKSSFDELEFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9U6</accession>
    <name>A0A0B1P9U6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001436">
        <property type="protein sequence ID" value="KHJ33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9U6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9U6"/>
    <dbReference type="HOGENOM" id="CLU_058251_0_0_1"/>
    <dbReference type="OMA" id="TYLTALW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37143" checksum="1F84968A64DD2884" modified="2015-03-04" version="1">MRHSIPLKNTRTLSRSTMTIISPRIQFFEITDQEWFPQYLRERIQSCLTLLWTLRIPLLQKSSPAQHVAQMLSRVLDDAGRYRYVDFCAGAGGPTLTIERELNSQLASHRFTGKNNENRPPVQFVLTDLHPHIPEWTKVSKQAENITFIPESVDATCAPSSVKSNYKQKICRFYNLSFHHFDDRLASSILRNSFETADGFGIFELQDRTLSSLIVVILSVVVLLLTTPFYFWRSPLHMFFTYIIPILPFVMLFDGFISCLRTRTPEEILYLTEKCGAPLDDWKIVYGREQHSWPCGYLSWIIAVKKTTKPQPIEFGDKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9X5</accession>
    <name>A0A0B1P9X5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g4368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JNVN01001030">
        <property type="protein sequence ID" value="KHJ34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9X5"/>
    <dbReference type="SMR" id="A0A0B1P9X5"/>
    <dbReference type="STRING" id="52586.A0A0B1P9X5"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_0_1"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="13">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="12">
        <location>
            <begin position="298"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="357"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="440" mass="47661" checksum="9E2F1AFDA436BE59" modified="2015-03-04" version="1">MKVNISTLPLTKLPIITTPHSGFKLQRRALSIHEYLSADLLRKYDVGVPAGSVAKTGAEAEVVAKKIGGDDLVIKAQVLAGGRGKGVFDNGFQKGVRVLYSQSEAKPIAEKMIGHNLITKQTGAKGRPCNSVYICERKFSRREFYLAILMDRASASPIIVSSSQGGMDIETVAKESPEAIKKTRINLHEGVTDDIAREIAKDLGFSERCIGDAMIVIQRLYKLFVEKDATQVEINPLTETIDHQVLAMDAKLSFDDNAEFRQKDIFALRDTTQEDPDEVLAAESGLNFIKLGGDIGCVVNGAGLAMATMDIIKLNGGNPANFLDVGGNATPKAIYNAFSLITSDPKVTAIFVNIFGGIVRCDAIAEGLISIVKQMNLSVPIIVRLKGTNMEIANQMIAESGLRIFSIEDLQSAAEKSVQFSQIVKIARNVDINVMFSQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA28</accession>
    <name>A0A0B1PA28_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dna damage-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001381">
        <property type="protein sequence ID" value="KHJ33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA28"/>
    <dbReference type="STRING" id="52586.A0A0B1PA28"/>
    <dbReference type="HOGENOM" id="CLU_002893_1_1_1"/>
    <dbReference type="OMA" id="HQDFLMR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="12"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="436"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="796"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127345" checksum="9A55628C41FA74F9" modified="2015-03-04" version="1">MAYLAPIHKPSSIRHAVKLNLLDPDESCLVVAKANKIEIWAFSGQGLELCFSDSFYGRVSMLAKIRPIGSTTDHLFIGTLRFSYFTVAWNSELKKLETVNLFENLSDSHMRESQSRDGCLVDPTGQYVMLELFEGVINLIKVTKPRKGRGDDYLDKAEQIRLSELKVRASTFLFTETKQPKIALLYSEGKDGNVRLVTYQIVDDKGHYSSFNPKKDRENELDGLDFSCSHLIPVPKGDRGQKRYMVRNSAVPKALLGGIIVVSESNMTYLDDESNAVIKYNLEEPSIFVAWEKLDGLNYLLADEYARLFALTILVDGPEVVGMKIRKLGKTTKASLMVLLSEGLVFIASHEGDSQLVKVDLNSEHEAIVLIQTFPNIGPILDFAVMDIGGLEGENKLNDYSSGQVQLVTGSGANDCGSVRSVRSGVGLEDEGILENLQGVTGIFSLKSHQESRIMDILMISMPVETRVFEFSSEGSIEEAHYFKDFNLEETTLLAMNTINGQELQVTPSSVILAGEASKRLKSAEWRPPEGQQITAVSGNFENLLLALNGTILVSLDIRYELHEVATREISSGDQVACIFVPDQCLGIGVVGFWRSGSISILDLHNLNLIQSEGLQKNNDASIPRSVALVQVLPANISGPTLFVAMEDGIVLTFKVDPSTFRLSGKKSIALGTQQVQFFILPQKNGLSNIFATSEHPSLIYGSEGRIIYSAVTADNVISVCSFDNKVYADTIIVATEEEVKISRIDTQRRTHIRTLPMGVTVRRIAYSPKERVLGLGCIKRELVRNQETVSCSFVIAEDVLFGQVGREFLLDKSEEVIECVIQSELHTSHTNSLAERFIVGTSFLENNESNERGRILIFGIDQSRSPYLITSLNLKCACRRVAILNGHIVAALIKTVVIYSYHETTTNSAYLTKICAYRCSTCPIDLAINDNIIAVADLQKSLVLLEYQPAKKEGNPDTLVEIARHYHSYWATAVSHLEDSSYLESDQEGNLIILARNMEGVTLEDRRRLELTGEFHLGEMVNRMQKIQVKPTFNAVIIPRAFLATTEGSIYLLSTIAPSAQDLLIRLQSSIAANIKTLGNIEFNSYRSFLNMDREASEPYRFIDGELIERFLDQDENLQNEICKGLGPHVEDIRGLVEELKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA72</accession>
    <name>A0A0B1PA72_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000333">
        <property type="protein sequence ID" value="KHJ35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA72"/>
    <dbReference type="STRING" id="52586.A0A0B1PA72"/>
    <dbReference type="HOGENOM" id="CLU_007859_0_0_1"/>
    <dbReference type="OMA" id="HGTMVAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="803"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="877" mass="99897" checksum="1C9489D3D6F98E61" modified="2015-03-04" version="1">MLHFRSESQPISTNSNGCNRTEITTHSFEYKDVKEDHVDDREKSQKASYDVSTRKNDLINGDSEMDADDENFKKGFTKMRILSTDSKSTRVDLSSTKSGVPSTEGEKISLNDRTLMSSQMIVINRDYGPEVKKNYHQIKKLDYIRKSIEIGMMIFILGLLCIDERVRQVIRFWNKELAYLCVIILILNVSYESRIPNHTRIRKGEIRSMQSTVSTLKDITPILYPSFIPILVSLLVFRNQPHDFGASIILALTSIPASLVPSYDGLNESNTTHWVLSLIPLIWKRETYGVVHLSLDNTPIRLETLALLSPLNQSLCSTLAFFTSTSLLPTELQLLSVALINLLLYARSPQAIILKSLLWGCGITILVSCYHVLNWSIILSRTPKWRFRHSKKEIYLRKRKSNNYSRKLYIKKQRVSGPVENIDQTDSDDASDFIRIVSDPLVLPRSNSLGSLRRNFRINQLLTMQPMPDMAKNPSVGLKIWPVKNRRKKHRSSASISRISKRILMLGRRKKKPSPSERSLYSLSLRQATIRKWLYAAYVYLCVLLIILIGIRKYVEKLALYGSEPIGWALVYLFGDLQIFREFVNSRNLYHWIQFPQPNLEPSILECKGLIEHWRLKYIGEANARIMLVLYWLTTFIIGLTIVLRFFSYVEVDTRRKFYHFLMVAVLLPTTFIDPTFTALALCLALAIFLLLELFRSTRLPPLSKPLANFLAPFVDGRDLKGPIIVSHIFLLVGSAIPFWLTLGSLPRLKSYHLNGWIIETRELSMVSGVICVGLGDAAASLIGRRYGRRKWCWGQDKSLEGSFAFAAAVLLGLVISKVWLKLGGWQSNNNDSYTMTFFKSGIAACVASIAEAAIKGVNDNVIVPLILWLCVKGLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PA99</accession>
    <name>A0A0B1PA99_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g1275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001182">
        <property type="protein sequence ID" value="KHJ33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PA99"/>
    <dbReference type="HOGENOM" id="CLU_032739_0_0_1"/>
    <dbReference type="OMA" id="STIHETW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17080">
        <property type="entry name" value="Ubl_SLD2_Esc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="382"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="459" mass="52376" checksum="AEF8D6DF27E23230" modified="2015-03-04" version="1">MNQIPAKKRSIFSKQAFTKVNVAKDPVDFFSCAKKVYPRLLEEEERKRQDKFKRKERQRSEGYEDSIEKSLDENQTVTNPSDGLVSCTSNESSPQSPFLSSLCKESNRSRSLSNNEDSNSLHSLDLKSSRISSVKKRRLLSLETPSKPIIILESDDEEISQSQLDPFQNDITCPPLRTHLANRQPDKIVEEYPEFIQQAREREKLKAKQRLTAASFHEKTSRPSEENLNDVFDPEPKPALELDPTVELLITSDLEGTRPLRIKRKLSQRLKEARLTWCEKQHIRTDKSGKPLEEVIFFTWRGKRLFDVTTCGSLGLKVRKNGELSPGQDGIGSNGNIHLEAWTEDTLKAKEEKDLENQALVNERDDNERESKSDKENGSTCKLILKAKDMEPCKIVVRPTTTIKKMAEAFRKAMAIPESTKISLHFDGDLLDPNSTIEDTELGDVDNVDTVEVYLKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAC6</accession>
    <name>A0A0B1PAC6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000974">
        <property type="protein sequence ID" value="KHJ34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAC6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAC6"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="240" mass="26494" checksum="A875EFEB3EB3F9F2" modified="2015-03-04" version="1">MLNAGNRLFLTGAKLEPSANWIPMIIPTVPSTIRKVQGQIEVSNSMLTDEFERVCAVRPAHVKLYGGNKAEAPHKTWMAYFSKAPRAGFRVFDESGIARPFKKQQPLEFCKRCNGHHPTKNCSRAPSYGNCGSTNHTEDLCMASTKCRNCGGPHRSDSRRCLARPTRSGAPTKEQMRTYRQIGEREYQAVLRAKAAGESAVFAENNIMDLTSSQDSEVGGDTDNILASPVENSKDCALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAD6</accession>
    <name>A0A0B1PAD6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAD6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAD6"/>
    <dbReference type="HOGENOM" id="CLU_002336_1_0_1"/>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119199" checksum="D14AA3B70E8A58A4" modified="2015-03-04" version="1">MSFKFPISSGPSTPERSFRPNGIENDIDFPSTPGDPFPSVPDDTYTPIGPPPDLSSSLIDIESPVKINSFTAKESVGSDFLRINKSDELNLQNQYEPQYQENRETSRDKSEERDEAEYSESEDHESSDSQHSYEKGDEEIEYYSDDDQENPDSESFNQEVESNLSMRSQNSDDDSKSKALKLLEDNIDGEIEGQEHYGWQEYALFGTSKYREIAQSMYSSMAVHPVEESDDLILATEAITLKLYQQDSNTENENENENENLENILARVSDELVRLWETYNKQTLICRSEEYTTTLGPGPQAPGFSKANFIASLTLRINYPKKITSSFTIREAKLPQTLIEWMDEHHNPYPNQHEEILAHKPSPSNHALFWDSVFNCLIRGKIKAVIDMINNAGWEYSKDVLDNINNIDSQLNNSNATLTNVERAMDVAKHILMKCPATHRDWNSRNNDWKLFRLRALQALEDLKRFNEGRDLDLENDDRMILEPGSFNETAKKARSLIPWNLYQNLVTLYNLLMGDISTILANSQDWCEATIGLVIWWDESKKDQGLILSRFHQPSRLSSKYSTSKFFHQKLRISFEAATSDSTDFQINSADDVQVALASLFQIDYESVIGFLRCWSGPVSCGVVEIASLAGWLPRAEEKSLINMGSLDQGDFELLGLTHSTPKSDDIKDKTLITYANNLSKRRELKSSANPETKLSSWEVSIAILGRLDSTELSVEIIRDFLDQFPLEDSSTVNKLWILLNSIGLTSHAESAAQRYADDLAGNSHKYGEALYYYALAHNNTKVKNVLDLLISSSLAQSSAYPSEKDLDDHLRSLLTNPQIALTEIATMDYEAARLLHSSLSGYATLRKFYDLRDEPLKLQTGKNEINLKSRKIQASVALIAVITSSSDHISGGLHDTEHDAVVHVDFLLALLGEAIVFVNQPDFILTVRQIETLLYAIEDLNSIPPNVYTICSDFFYTVMESSREISLTRPQHHLKMGSNRIGSHAVGNSLLASQLKQLVNVSGKESREMTQRGWDWRDKVSAGTTADELLKLLRLGLAKDLAKAWLLEVDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAQ6</accession>
    <name>A0A0B1PAQ6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001078">
        <property type="protein sequence ID" value="KHJ34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAQ6"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="265" mass="29718" checksum="E1FB1154C0F72AF0" modified="2015-03-04" version="1">MLSPAGLREVIVKRLSISPASIGLIKPVLSGFAISPSNEESRKNLLAAAGGLFMSGATLEAASNWTPLLVPTVPRLITMLEGQVEVTKSMLADEIERVSTIRPTFVKTYGVSNPDAPHRTWMAFFSEIPRTGFRVFDESGVTRNSKKKKQIEFCKRCNGHHNIRTCSRAPSCGNCGSTVHSQDMCIAATKCRNCGGPRRSDSHRFLTRPTRSSKPTKEQLKFYRKAGVMTRKEVALIFYLKLIYKVVVQRERYLLWLARYVYTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAV4</accession>
    <name>A0A0B1PAV4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g5792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000421">
        <property type="protein sequence ID" value="KHJ35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAV4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAV4"/>
    <dbReference type="HOGENOM" id="CLU_556647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="434" mass="49528" checksum="3B7D18E7F08DD92B" modified="2015-03-04" version="1">MGRYMRTKKLFLDDKIMILAIIPLIARMCCETTVVTHGTNNVDTKSLTWSQIRSREWGSKIVLVSRILYIFFLWTTKYSISIFLRTLTSSIWTPLHQTYLVYIHIFLFLTLITTIVTVLAPCRPFNHFWQVVPDPGTQCRQNYVYVFTTGSLNILTNIVLVVFPIPMVLMSGLLLKQKINILLRLSLPLFPITSTVYAIPALCGRDPFATSQIRRTLLVSIDILLTAFSANAVVLFSLLQDKGYKKSKFKHMQERYNTNRLANTQRSHQTGSMEIATVELCDVGNLLHEADLGNIIDVHKIRGVNQLTSKACHHNTRLGEKKKNEPIDISAISISQEHGARREKIRDMRLGMDSYQCQPEFINEANDQIIEISGQESRYWKGVSNKGSYPNRFSDVENEVLHPSPVYCGGIRLDHVKEIHLEDLVARGWGNDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAX6</accession>
    <name>A0A0B1PAX6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000835">
        <property type="protein sequence ID" value="KHJ34510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAX6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAX6"/>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="OMA" id="YYVDWAQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002079886" evidence="1">
        <location>
            <begin position="18"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="392" mass="43459" checksum="7BB4D218AAEB56FF" modified="2015-03-04" version="1">MLLFLTILFILLLKILAASENDFITNSRLANSALKQWYNTTTGVWDTTGWWNSANCLKTTGDLAAIDPRVRSAALDIFANTLEKAPKFNEWAKKEIEPDYMIHSLSNGVLKWPRQDPTGFLNGFYDDEGWWALGWIQAYDVTKNSQYLQTAVDIFNDMNNATTTPCNGGIWWDRDKTYVNAIANELYLSVASHLANRAQGSDRQKYRQIAIKQWNWFNASGMINKDFNINDGLTADCKNNNGTVWSYNQGVILGGLVELSKATSDSSYLRPAQGIALAGIKKLSDKDGVLHDPCEPNCGTDGTQFKGIFMRNLLALQKIAPNGKILSFITMNAASVWKNNRNTDNQFGINWAGPFIGPANASTQSSAMDAIVSASSIQKYFENGIGSNNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB73</accession>
    <name>A0A0B1PB73_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gpi anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000800">
        <property type="protein sequence ID" value="KHJ34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB73"/>
    <dbReference type="HOGENOM" id="CLU_1256865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002062018" description="Gpi anchored serine-rich protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24109" checksum="DB502D90C760049A" modified="2015-03-04" version="1">MRNHLVLSICCTTAAMAIDPTAQPIIMEAAATAEYYFPTATACANSPYYQNSTVNFPKLPSPTGQVPYMPNPDNNDDNDDDDDDDDDDDDDDDDDDDVDVDKKMPYKPDVQEKKPQMPSEHSDRQHFMPDDQLLQTVTMTTTTCIPTVITSVITLKKPGPTSRPVYTSKPDYVYVPKPSASSYNPKPDPNKPQFTGAASMAECSGLLVFLVSAIVLLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB93</accession>
    <name>A0A0B1PB93_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001146">
        <property type="protein sequence ID" value="KHJ33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB93"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="122" mass="13572" checksum="09613BB43BBD514C" modified="2015-03-04" version="1">MISSIDNTLVNFKEVEIEEIVAFKAYLRHAIASFALMDSSSSSSLIPFHTRPNKENVNSRIDDKKAKKVQVETPHIALTSVLNRGKTQEVALPKTSTTNEKTWIIVARNGHKKARAVVGDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBR9</accession>
    <name>A0A0B1PBR9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">EV44_g0759</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="JNVN01000907">
        <property type="protein sequence ID" value="KHJ34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="52586.A0A0B1PBR9"/>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 17 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="20">
        <location>
            <begin position="1242"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="2025"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="21">
        <location>
            <begin position="2400"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2340"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2351"/>
            <end position="2360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KHJ34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="2432" mass="275752" checksum="0CFD0C1E7CC326B5" modified="2015-03-04" version="1">MSSQIAQEALGRIVQELKSRGSEDLRRRAALELRELVNVTARDLPPERFLEFYNVVNTRISQLITHPADPAERLGGIHALDALIDFEGVDSAQKVTRFTQCLRTVLKGKDLAPMQPAAIALGKICRPGGSLISELVESEVKTALEWLQSDRVEERRYSAVLVLRELARNAPTLMYAFVGLVFDQIWVGLRDHRLLIRQTAAEAISASFQIIRDRDQAMRQTWQLKIYDEAVTGVRQGSVENIHGSLLVIKELLQQGGMFMHEHYPEICELVFRLKDHRDVQIRRTVVMLIPELANYSPNEFAKNFLHKFMVFLSGMLKREKDRNDAFLAIGNIANAVKSDIAPYLDGVLIYVREGLSVRSRRSGTVDPVFDCISRLAQAVGQTLSKYMEALLDPIFACELTPKLTQALVDMAFYIPPVKKTIQIRLLDMISKVLCGEPFKPIGAPTSNSISSAPVVPKDSKDPLAFEHRQSEVKLALNTLGSFEFSGYVLNEFVRDVAIKYVEDENPEIRKAAALTCCQLYVRDPVLNQTSYHAIRVVSDVIEKLLTVGVADPDPCIRKTVLAALDERFDRPLAKAENVRTLFFALRDEIFGVREIAIKIIGRLTHVNPAYVIPSLRKVLIQMLTELEFSEFARNKEESAKLLSLLVQNSQDLIKPYVDPMVAVLLPKARDSNPSVSATIITAIGDLAAVGGLEMKPYIEELMPIIIEALQDQGSIVKREAALRTLGQLASNSGYVIKPYLDYPNLLEILQTIVRTEPHRGPLRQETIKLMGILGAIDPYKQQQVIGISSESQQRLEINQVTDISLMMSGINPSNKEYFPTVVINSLLPILKDQSLLQHHAAVVEAIMNIFRTLQLECVPFLEKVIPAFITVIRNAPATKLDSYFSQLSVLVGIVRQHIRKYLDEILVVLQEFWNHPNGLKTNILLLIEAISRSLEGEFKIYLAKILPFMLSALEKDVTTRRITSEKVMHAFLVFGQSAEEYMHLIVPVIVGVFEKPQQPTFIRKYAIETIGKISRQVNLNDFASKIIHPLSRILGGNDVTLRLAALDTLCLLIFQLGKDYLHFAGTVSKILNMHQITHQNYELLVSKLQKGEVLPQDLNADERSRYSVDENLLIEVQNKKLDSNPVHLKAAWDATGKSTKEDWAEWMRKLSVTLLTESPNQALRACASLAANHPPLARELFNSAFISCWGDLFESYQDDLMQNLEMAIQSPQVTPDLLGILLNLAEYMEHDDKAISIDVRLLGRVAGKCHAWAKALHYKELEFLQDQSGSAVEALIHINNQLQQYDAAIGILRRAQLYKDGITLRETWFEKLERWEEALEFYREREEEFPDQSQTFDVIIGKMKCFHALGEWEALSALAQDKWHTSSLDTKRKFAPLATAAAWGLGQWDLMDDYLGVMKANIPDRSFFGAILALHRNQFREATKFIQKAREGLDTELSAGVSESYNRAYTVVVRVQMLAELEEIIVYKQCSNNPEKQGTMRNTWEKRLLGCQRNVEVWQRMLKVRALVISPKENMQMMIKFANLCRKSGRMGLSEKHLKMLIGTDLTLDSVLPTQSTSLGANSNSSRRLDRRDHLVAMRIPPPVQYAVLKFHWANGKQEAALNALQSFTKDLTDHLRAVQIQAQTVESLDIQNSLSTNGDGNIPELNPFIGNTQKFNVKQYAEYYVLLARCYLKQGEWQVALKKGDWSHDSVSEILDSYHAAANFNPNWYKAWHSWALANFEIVQAISKKGEVGNEIAPPHNLTLSYVVAAINGFFKSISLSHGSSLQDTLRLLTLWFTHGGSPEVNLAVTEGFLSVSVDTWLEVIPQLIARINQPNSRVQQSIHNLLGDVGRAHPQALVYPLTVTMKSAPNTRRSRYAMQIMESMRQHSAKLVEQADMVSHELIRVAVLWHELWHEGLEEASRLYFGDRNIDGMFATLAPLHNMLDKGPETLREISFAQTFGRDLQEAREWCDTYRSTGDVADINQAWDLYYQVFRRISRQLPQLNSVDLTYVSPKLLRARDLDLAVPGTYVSGKPIIRISSFDSNFNVISSKQRPRKLSLTGSDGASYTFVLKGHEDIRQDERVMQLFGLCNTLMIHDSESCKRHLNIQRYPAIPLSQNSGLLGWVPNSDTLHVLIREYRESRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYAIDNTTGQDLYRVLWLKSKSSESWLERRTNYTRSLGVMSMVGYILGLGDRHPSNLMLDKVTGMIVHIDFGDCFEIAMHREKYPERVPFRLTRMLTYAMEVSNIEGSFRITCENVMRVLRENKESLMAVLEAFIHDPLLNWRLTAGETSPTGPKINSDIHEPIAAQQGRRISLIESDITPTMRDYVTEPGGPPSSRSRARTNSTAQDYNTQDNFIQETQNARAMQVLHRVKEKLSGTDFKSNEELNFVSQVDRLLIEATKLENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBS0</accession>
    <name>A0A0B1PBS0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g0877</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBS0"/>
    <dbReference type="STRING" id="52586.A0A0B1PBS0"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="52"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="204"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="475" mass="53077" checksum="8FC93BFB23AB31CB" modified="2015-03-04" version="1">MASRRLALNFNRGLNARSRINNITRLKRGLATPTIRNDLKTETTTLTNGFTVATEHSPWAQTSTVGVWIDAGSRAETDRSNGTAHFLEHLAFKGTGKRTQTQLELEIENMGGHLNAYTSRENTVYYAKAFNADVPVTVDILSDILQNSKLEPLAIERERDVILRESEEVDKQLEEVVFDHLHATAFQGQPLGRTILGPAENIRSIQKEDLVNYIKTNYTADRMVLVGAGGVSHAQLVDLAEKHFSNLPSAKLSNTLQENKVKPKFWGSEVRLRDDTLPTANIAIAVEGVSWKDPDYFTALITQAIVGNWDKAMGNAPHLGSSLSSFVHKNELANSFMSFSTSYSDTGLWGIYLVTDKLTRIDDLVHFTLREWSRLCYEVTEAEVERAKAQLKASILLSLDGTTAVAEDIGRQIITTGRRMGPEEIERQINEITEKEVLDFAQRKIWDQDIAVSAVGSIEGLLDYQRIRNDMSRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCD7</accession>
    <name>A0A0B1PCD7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000782">
        <property type="protein sequence ID" value="KHJ34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCD7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCD7"/>
    <dbReference type="HOGENOM" id="CLU_077196_0_0_1"/>
    <dbReference type="OMA" id="YDATIDH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="214" mass="24294" checksum="89F77353A25C575A" modified="2015-03-04" version="1">MSGSQLQNVLLRHCPAILRYQKLITKAAICNITTDSYPTAHDVSIRSQPEAVDNKKIQVGKGQPLYSAEVDQASSPFSPIPKRPNGINQQGDIIPAAVVSGVPVEIQSRTVRIYRPAKPATQSGNWYGDRWRMDWDILSKGHRWENPLMGWQSSGDFMQATHMTFKTKEEAIQFAENQGYEYIVHEPNTRKITPKAYANNFLWSDKKLKHVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCR1</accession>
    <name>A0A0B1PCR1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EV44_g0382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000870">
        <property type="protein sequence ID" value="KHJ34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCR1"/>
    <dbReference type="STRING" id="52586.A0A0B1PCR1"/>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="OMA" id="EMGLFML"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KHJ34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="210" mass="24306" checksum="32B3B241D446DD54" modified="2015-03-04" version="1">MTLYYSMVFLLLVSEMALFVLLIIPLPFTIRRKIFIFISENPTIAKLQYGMKIAFIFILILFIDSVNRVYRVQLELAETNRQQGSAVMGHERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYTLILDVLRLEEKVKKYEGNPKASGKDSQKLANAGSPGEIARLRMSLAEKDRDLETLKKQSEGLSREYNKLSDQFGETEIDSTPKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCS3</accession>
    <name>A0A0B1PCS3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative duf21 and cbs domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g4705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000158">
        <property type="protein sequence ID" value="KHJ36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCS3"/>
    <dbReference type="STRING" id="52586.A0A0B1PCS3"/>
    <dbReference type="HOGENOM" id="CLU_011310_3_1_1"/>
    <dbReference type="OMA" id="TCQPEDE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="116"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="321"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="534" mass="58836" checksum="5AAA45030B820DFB" modified="2015-03-04" version="1">MVPVAPYASYHTKLQNWKSGRTTSFFLKERFNAVKSAKRLLNLTWLRGTLKQIHCVGKTMSFGHSTPFGHTNQIYSRSSIGLLKIVLFVFAQASHAIVIPLTQFYGLDNADESTEEELSLWLYLVIAAVLVLAGGAFAGLTIALMGQDSVYLQVIATSGEGKQQRHAKSVHNLLQKGKHWVLVTLLLSNVIVNETLPIVLDRSLGGGWPAVLGSTVLIVIFGEVIPQSVCVRYGLSIGAFMAPFVLALMWTLAPIAWPIAKLLDKLLGKDHGTVYKKSGLKTLVTLHKTLGSSPTERLNQDEVTIISAVLDLKEKAVSDIMTPIEDVFTMSEDTILNEETMNTILSAGYSRIPIFERGNPNNFVGMLLVKILITYDPEDCKRVGEFALATLPETRPETSCLDIVNFFQEGKSHMVLVSEFPAENYGAIGVVTLEDVIEELIGEEIIDESDVYIDVHKAIRRLAPAPKARARKRHVINQDEVTPQTTLRKFPENKGDIVIKKHLDTGLNENSATSTHAVVNPKVDIVCEGTVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCV2</accession>
    <name>A0A0B1PCV2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000848">
        <property type="protein sequence ID" value="KHJ34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCV2"/>
    <dbReference type="STRING" id="52586.A0A0B1PCV2"/>
    <dbReference type="HOGENOM" id="CLU_032395_0_0_1"/>
    <dbReference type="OMA" id="RPREYHS"/>
    <dbReference type="OrthoDB" id="4463286at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="480" mass="51579" checksum="A1D5AF9357B0667F" modified="2015-03-04" version="1">MSAAVAMTPSPAPHDRSSYMDRANPSSSNTSKSSSASSTTAPPPTNYAGSRPSSRQLKATTKATATKTSPKIPRNESISSVIVKKEPTSPDIRHRPQKLDLSASNNNAKSSNEATNSFPHTGTRPLAGPLTARMDGLGIQEVGLACISPGFNTQDPTKRDHLQRSMSVREQQRTLIESRMNKQSAMENNVSLESTKDHEAGTANASKGPVSSKKKVPPGLSIVAPSHEDFAQERIIQSAPLNHSFTSSRYNTQPLTRHTVNQPSNFSKTSHIHHVNTHNHVRSPIQPISATSANTTIHHVPAIQTSSRLPPIMDIFAGESLALRQSIGQGSSHTNGATSNSAQSNNLPPFPSPGQSGTQTLQSGRSREYRSAEDAQADLSGGRPELLPKIVHYGGHQPPPTPPSPRTTKSIRLSDPNHSGGSRRRTRVEYEEGSTPPLGNGPSTGRRTGPFGESRSSPTNSQKKEQFIRLCADAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCZ7</accession>
    <name>A0A0B1PCZ7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EV44_g2718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01000131">
        <property type="protein sequence ID" value="KHJ36133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCZ7"/>
    <dbReference type="STRING" id="52586.A0A0B1PCZ7"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="81"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="281"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="699"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KHJ36133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="802" mass="91405" checksum="2377B8EAD3762D13" modified="2015-03-04" version="1">MPSATTEHKPKSTIQHVKNARSQKRKRELEKHEDLTRAVEELDIQSSNFNEFSDLPLCQATAAGLEASHFKKLTDIQSKAIPIALKGKDILGSARTGSGKTLAFLIPVLDNLFRLRWTELDGLGALIISPTRELAIQIFDVLRKIGRHHSFSAGLVIGGRSLREERERLGRMNILVCTPGRMLQHMDQTAVFDVGNLQMLVLDEADRIMDMGFQQSVDAILEHLPKQRQTLLFSATQTKKVSDLARLSLHDPEYVAVHEDASSATPAALRQFYVVTPLPEKLNTLYSFIRSNLKSKIIVFLSSGKQVRFVYESFRLLQPGIPLLHLHGRQKQTARLDITSKFSVSKNSCIFATDVVARGLDFPAVDWVIQLDCPEDAETYIHRVGRTARYELDGKAALFLDPSEIDGMLKRLEHKKVPIQQTKPKEKKKQSIESQLQKFCFQNPELKYLGQKAFSSYVKSIYLQKDKEVFKLDEYDLKGFASSLGLPGAPKIKFQKGDDARKIKNTPRLMPLSDDDDEDEDEEVKATRKSKTKEVRTKYDRMFERRNQDVLSSHYSKIIAEDHTVPNQYEDAEEDNEFLTVKRVIPVDDENKNDDVSQMIPDLKPKIITGIGKEQITIDSKRKEKLLKSKKKLLKFKEKGTKLVYDDDGNPHQIYELEDEDAFHKKGAPELQRAKFLEEEASRIKVADFDDKILVKKKKKEKREKLKANRQLAENSEALKNLPILTHGEATDSENEDPLAFLASLPQNVDEVEERPSKRPKKQSKNSSNDEENNRVNDDNTQVNDNQESLENLEKIAAKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDJ3</accession>
    <name>A0A0B1PDJ3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000740">
        <property type="protein sequence ID" value="KHJ34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDJ3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDJ3"/>
    <dbReference type="HOGENOM" id="CLU_1416136_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="192" mass="21389" checksum="01BCCC9D839646C2" modified="2015-03-04" version="1">MIDTGATATSTAGYNQYLAYNKLSNVNLDISTAGQASVRFGIGSAVSIGLVMVHMPLGLVEFHVIKVDTPFPMSIADLDRLGAYYNNVNDILVTKTSESLPVIRHFGHSFLLWKTSPESLIQEHLATNTALLTEIELRRLHKRFDHPFINRLRHILEPSGHTDFDKNAIEKIIKFSMTVNLTVNPLAVFILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDM2</accession>
    <name>A0A0B1PDM2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000554">
        <property type="protein sequence ID" value="KHJ35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDM2"/>
    <dbReference type="HOGENOM" id="CLU_163547_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="73" mass="7970" checksum="8E3DDB21F670B1AF" modified="2015-03-04" version="1">MPVKSKSSPSRGAGVNAQYALHVWDSQEDSHNLFLTSGLPFINAGLNHLRFYFTFPSVPVFMKPSTIGSGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDN9</accession>
    <name>A0A0B1PDN9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gtp-binding protein ypt4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000710">
        <property type="protein sequence ID" value="KHJ34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDN9"/>
    <dbReference type="STRING" id="52586.A0A0B1PDN9"/>
    <dbReference type="HOGENOM" id="CLU_041217_6_0_1"/>
    <dbReference type="OMA" id="HRFVKSE"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="327" mass="35863" checksum="FC68063AD5A70DD6" modified="2015-03-04" version="1">MVRQRSKSGTSNELSRTAGNQELGSMYDYLAKIILLGPSGSGKSCLLHRFVKNEWRVLSSQTIGVEFASKIIKVGSGSRRKRIKFQLWDTAGTERFRSVSRSYYRSAAGALLVYDISSYNTFTSLSSFIHDARALASPNLAILLVGNKLDLADQGDLIDVGSSNQYTDTSEISSFKETENFSNLAVGSLNSNFGLDSKWTASVASDGREVATDEASKWASANNITATVEASALSGENVDEAFNRLARIILTKIELGEINPDDPMSGIQYGDSVWFTDGDGASVVSSMTMQEGTSRRRTRSKWGMGGMREWEEVFRIRGITRRKKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE93</accession>
    <name>A0A0B1PE93_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JNVN01000471">
        <property type="protein sequence ID" value="KHJ35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE93"/>
    <dbReference type="STRING" id="52586.A0A0B1PE93"/>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_1"/>
    <dbReference type="OMA" id="SDWPVME"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="5">
        <location>
            <begin position="47"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="22634" checksum="DF2DDDADA336EBE0" modified="2015-03-04" version="1">MSRSLDNNRVFFMENEAPERNPKGRVLDHAKPTTSLSTATMTATTTALIAVTMGSDSDLPILKPGLELLKTMQIPFSITITSAHRTPQRMIEFASSAESKGIKVIIAAAGGAAHLPGMIASCTCLPVIGIPIKASTLDGTDSLLSIVQMPRGVPVATVAINNSVNAALLAVRILGTSDETIKNKVIQYSKQMSEEVLSKAEKMEKDGFSNYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEA5</accession>
    <name>A0A0B1PEA5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000602">
        <property type="protein sequence ID" value="KHJ34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEA5"/>
    <dbReference type="HOGENOM" id="CLU_752706_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="368" mass="41807" checksum="63C90E2AF815D733" modified="2015-03-04" version="1">MKGLSRKPSDKVEALFHKGMDQKKRDKSQNYESCIFPMIKNEYNNTESQKILLAMQKELNNKNEAKFLNTRKKFETNFSPEESTQHDNCMSVEQDKNNIQPFKHKNKLSRGLINEQRSYSFESPQQQCRYARAESVPHEVAENHAIDKGGARLVEGGTQIFQLTQENLQHKNRTKSGAFREHNAIDTIPTNSQDTTLLTPAKTIPIPSCGLVEEKVKHFEKIRSTGKTGTIPTKRSITRRLNRSLRGFFDFWDSNEKIRVKNENSSKDELNGSRKEFQSVGSQKIKARDILNNDVVSSKNLSKMKNKFLGNSGKSSESSSLDEMDVWIIKKVDCGLKQPKPLRAVEIKSMVLLCSSYGGGNKISSISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEB5</accession>
    <name>A0A0B1PEB5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60s ribosomal protein l30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g1573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000597">
        <property type="protein sequence ID" value="KHJ34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEB5"/>
    <dbReference type="STRING" id="52586.A0A0B1PEB5"/>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="109" mass="11673" checksum="8638B687C46EE5A5" modified="2015-03-04" version="1">MAPKKSKKTADNINNRLALVMKSGKVTLGYKSTLKTLRSGKAKLVIIAGNTPPLRKSELEYYSMLSKTNVHHFAGNNIELGTACGKLFRCSTMAILDAGDSDILSGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEC0</accession>
    <name>A0A0B1PEC0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Mitochondrion inner membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000457">
        <property type="protein sequence ID" value="KHJ35246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEC0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEC0"/>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005678">
        <property type="entry name" value="Tim17"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00980">
        <property type="entry name" value="3a0801so1tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ35246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="159" mass="16572" checksum="528B854515867098" modified="2015-03-04" version="1">MDHTRDPCPWVALNDFGGAFCMGAIGGAVWHGIKGFRNSPYGERRTGAITAIKARAPVLGGNFGVWGGLFSTFDCAVKGIRKKEDPYNAIIAGFFTGGALAIRGGFKAARNSAIGCACLLAVIEGVGIGFQRMMAENTKLVVPQPPPAEVSKGLPAMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PES3</accession>
    <name>A0A0B1PES3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000255">
        <property type="protein sequence ID" value="KHJ35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PES3"/>
    <dbReference type="STRING" id="52586.A0A0B1PES3"/>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="322" mass="35873" checksum="F9F057F5B95DCA3B" modified="2015-03-04" version="1">MMAIRGVFSLMRIRASIATPTTRPLVSQIRAKSTDISPSAPAYKAIYQRINPLKNHDSPPSWSAQEAVSNILYETPTPSSAPAKRHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCHTEIEDLSRMTIVLSGQDSIVEQARRQLEDLVPVWAVLDYTHSALVQRELLLAKINILGPEYFEELQAHHREINMSNGNSNLLEMQQEQLITYSAEQTKFHPRNLPISEALRHKHEHLKSITYLAHQFGGKILDISTNSCIVEISAKPDRIDSFMKLIAPFGILESARTGLMALPRSPLYGPNENEQTKDTDENLDTGLLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF37</accession>
    <name>A0A0B1PF37_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g2449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000366">
        <property type="protein sequence ID" value="KHJ35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF37"/>
    <dbReference type="STRING" id="52586.A0A0B1PF37"/>
    <dbReference type="HOGENOM" id="CLU_057366_0_0_1"/>
    <dbReference type="OMA" id="MLDMNVK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="289" mass="32468" checksum="5E5B36A7A497EE37" modified="2015-03-04" version="1">MPICVECRFPVRTLYTEYSGADDKSSGHGVRLTVCQNCGCFCDKYVEHDHVVLFIDLVLIKPQVYRHLLHNTFMREEDRFDPSIIRLGILLLLFDVYLTWARIEKQTSSSTANPYDSTNFLRLAQKPIIFQYLFFLILCTISNLAFHLSIRFLTSSLHSPLVKTGLLPRYSRPNSVSTALLVSSSTKLFPILMVIWEYDIPAAARSLGWAVVANNVEALNILLDCGYGTAAIIATFGVITRSVIGRSILWATHLDKVDTVGNLSVAVHGKLVYVVIELAKEWGKRLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFV5</accession>
    <name>A0A0B1PFV5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g2625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01000380">
        <property type="protein sequence ID" value="KHJ35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFV5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFV5"/>
    <dbReference type="HOGENOM" id="CLU_001872_1_1_1"/>
    <dbReference type="OMA" id="VKQIKLV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="53"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141729" checksum="4459B0DF973D3FB2" modified="2015-03-04" version="1">MGTNTHVPQDHPPASRSKLGSENIRKEKIPGMLKSDGGIGKEKVAQNLGLRDYHLGECLGKGAFGSVYKAFNWGTGEAVAVKQIKLGDLPKSELKMIEAEIDLLKNLNHDNIVKYLGFVKSSDCLNIILEYCENGSLHSICKSYGKFPENLVGVYMGQVLLGLQYLHDQGVIHRDIKGANILTTKDGKVKLADFGVSTSTLAGADKEAQVVGTPYWMAPEIIQLSGATPASDIWSLGCTVIELLEGKPPYYKLAPMPALFAIVNDDHPPLPEGVSPAARDFLIQCFQKDPNLRVSARKLLKHAWIMGSRRTDAPVAKPPANFNEAVEEVKQWNEALKSPTSAGFKVISKSNFASPMPHRGMIHPLRNVQNEKRELSSNTKPKSLLQFGKPKNSAEAFRSPETKADDNWDDDFASSISPSALHLPQFKPHDNFGGKLSTDRLKAYASFELTPNENENWDHNFEGDLITIKGPQNYEELDSHELETIRPFQFRPAVIKEAKKKIDYKYLSSAQSGSISSPIDIISPLKEKRLSSPAKHSSATREPLVDNYLTQFLENDNSLNKRLSNKDEALSPLLFHPSDLTSIQRPSNSTSNYMNGSLSRQSSTRVQRKQIHRARSVDQIQKFAEDEDDEDFSDIFADDSLIVKDYESDRESEDGGRALLLNSKLSSNSWLGDEDDEDDPFASLEQGFDEMDLQANIARDKHARLCTLVEGLISSLKVTVEHELISDVSAQLLDVLYESEDAKALIISAHGMLPILEILEPCTVKSRQSMILRLLKVVNTIILDNVEIQENLCFVGGIPIITKFAARQYSNEIRLEAAAFVRQMYQTSTLTLQMFVSAGGLNVLVEFLDEDYDESRDLLLIGVNGIWNVFELQGPTPKNDFCRIFSRSKILSPLALVLDRVLHEEDSLSELVEGRIVNIFFLFSQAENYVKEVVADRVVIKRVLKDLSRMTPVHQITMLKFIKNLSMLSTTLDNLHAANAIELLIDLLSSSMKEKSPHFREISNQVLNTMYNLCRLSKVRQEDAAINGIVPLLHRIMKTTDRPPKEFALPILCDLAHSGKVGRKYLWQNKGLEFYVSLLGDQYWQVTALDAIFVWLQEETARVEKYLLEGNFIQAIINCFSPHRANAFDYNLLEPLQKLLRLSSPLAMSLAQPDLYSGLIQKLSHKKAVVRLNLLRIVRSIIDPKDENSLGITDHRLFEAIRRLAESDNAVLVRNMAEELVRTKFKDVSGTETSRSRLGQVNSRSNKTGGLGTQVKPPKMNHIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PG30</accession>
    <name>A0A0B1PG30_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000247">
        <property type="protein sequence ID" value="KHJ35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PG30"/>
    <dbReference type="STRING" id="52586.A0A0B1PG30"/>
    <dbReference type="HOGENOM" id="CLU_000680_4_1_1"/>
    <dbReference type="OMA" id="THIEHAT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23373" checksum="AD5CFD783575389E" modified="2015-03-04" version="1">MAFGFVDDTNLVAWGRSARENCYTLELAHSKCLAWAKRYGAEFAPEKYQLIHFSRKRGSSEDLKEKIELEDITINPRSEIKVLGVLVDSRLRWGPQLANAVQKGEVAFNALSRITSSVWGPSVRSSRLLYTAIVRPTMLYGSQVWGIRPNGGSLVKSLLGKLEKVQNKCLRRITGGYKLTPRAILEREAEILIELDLEIEIVRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGN5</accession>
    <name>A0A0B1PGN5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g6140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGN5"/>
    <dbReference type="STRING" id="52586.A0A0B1PGN5"/>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ36021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="456" mass="52139" checksum="A2361AFE53B32157" modified="2015-03-04" version="1">MKSNNISNKISIGYYLAAIILRIVLLIYGIWQDSYTPLKYTDIDYFVFTDAARFVAQGQSPYMRETYRYTPLLAWILWPTTLFSSSKFHLWLFSLGKIIFASGDIIAGYLTVQILKNSLKISNTRALGYASIWLLNPMVATISTRGSSEGLLGALVITLLWAVLQRKVILAGFLLGLAVHLKIYPFIYGPSIIWWLDDRNITTTTITTTTTAPTTVEKNNVTTETHYKKKRSFIDQRVIWNFFNSSRLTLVGVSLLTFASLNILMYSIYGQPFLQHTYLYHVIRLDHRHNFSPFNTYLYFLSSTTSTSSSSSVTPNVYLVKLAFLPQLFLSAFAIPFLLAKKDLPSTMLAQTYAFVSFNKVCTSQYFIWYIVFIPFYLPKSSLLSRKYLGSLVVILWIVTQAIWLHQAYQLEFLGRSTFIPGLWLSSILFFFVNSWILGIIIKDIGLGLKKKSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PGV6</accession>
    <name>A0A0B1PGV6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 26s proteasome non-atpase regulatory subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g4494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000148">
        <property type="protein sequence ID" value="KHJ36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PGV6"/>
    <dbReference type="STRING" id="52586.A0A0B1PGV6"/>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="265"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="486" mass="56136" checksum="B698F7A1E6BAF630" modified="2015-03-04" version="1">MSAEPAFKTEKDFSKEVDNQIPEAKDLAKSNVQAAIEKLALLEKQTRQASDLSSTSKILTAIVTISKESGDWSLLNEQTLLLSKKHGQLKQAITKMVQVVMSFLDSAPDLETKLSTIETLRTVTDGKIFVEVERARVTKILSDIKRQQGDLKAAAEVLCELQIETFGSMQRREKTEFILSQVALCIENEDWTQAGVLSRKISTKYLSRKPKKTEEQLKKEEKELENKRAVGEDVSEIVDDDVTDLKLRYYEQQITLAKFEDNYLEVCKHYRQVLDTEAVENDPQKLQAVLQRIIYFVILSPYNNEQSDLLYRIYSDSRNLQVPLDGQLLKLFTIHELMRWPEVSKTFGPHLCNTDIFDSHEGQSADKKAFQRWEDLRKRVIEHNVRVVAKYYTRIQVPRLCQLLDLDEDETEKYISHLVTNKTVYAKIDRPARIVNFAKPRDADEVLNEWSANMRNLLGLLERIDHLITKEEMMARIQPAKTIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PH90</accession>
    <name>A0A0B1PH90_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000113">
        <property type="protein sequence ID" value="KHJ36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PH90"/>
    <dbReference type="HOGENOM" id="CLU_018153_3_3_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="342" mass="37600" checksum="6CB52E6346299CC6" modified="2015-03-04" version="1">MICTTVLSNIDSTLANLTEDIEKEEAEAIIACLRLAISNFAAADSSPFPPRVPTHTRPSKDNRNGKSKEIDKNLTKKIAVATPRFILNPGPGREFNINTELPRIPKLSDNSPATVARKGHKKSRIDIITSARVAPAKKTAIRPTNKDKTTSPTKAILDNRLFLRLPQDHEWRKLSPAGICEVIVKKFLISPLMRKIKPVHSGFALSPSSPEAREQILKAENGLFLSGLKLEPATNWLSILVPAVPAFIHMEQGKVEVDKAMLSDEIERVCSVRPNSVNAAMGIMPPKIAQELRPAGTVAQQTMLKTSVWLPRNVEIVEAPIALKAADASLVQLAWEHQLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PI21</accession>
    <name>A0A0B1PI21_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative c2h2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g6245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000126">
        <property type="protein sequence ID" value="KHJ36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PI21"/>
    <dbReference type="STRING" id="52586.A0A0B1PI21"/>
    <dbReference type="HOGENOM" id="CLU_037132_0_1_1"/>
    <dbReference type="OMA" id="NAFQMQQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="494" mass="54240" checksum="59B3FC5BF7E296FE" modified="2015-03-04" version="1">MVAKKKRNHPDIEELLARPWCYYCERDFDDLKILISHQKAKHFKCERCGRRLNTAGGLAVHMNQVHKETLTNVDNSLPNRQGLEVEIFGMEGIPEDIVQAHQQRIIAVYYQAEAERRAVTGNPGPGGSANSGQPKKPKFESPSELKKRLAEHKARKSEQVAAGACSNINNPPVAADQNNLIGLSPNSFNAPAIAQPQVNNTGSQGASYGSFPQEPYTQPAVAYQQPFSQQSPFPGPPGTPYQSQYSPPQQYAGIQPFTSSFNSGQNFANVPQFGSGSLQQVPNQVNGYQQTPLQALPPHNGLPNRPPSLPPAPGLPQRPSFGAPVVPSYQMQQLHQGPHQGVWAGNGLKSHEQKSAYLLPQGYIGDHSNSAMMAKDHNTGPIRETDDIDEIIRMAEAGIKPQKINDGAINKPLSTFQAPNQPQVTDQIDTTKAEKIEKKLKKEKSMKMIYSDNELSPEEKMVMMPRYAFIPDEKSELTPMDTVLVSGDASIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVB0</accession>
    <name>A0A0B1NVB0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative g1 s-specific cyclin cln1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004594">
        <property type="protein sequence ID" value="KHJ30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVB0"/>
    <dbReference type="STRING" id="52586.A0A0B1NVB0"/>
    <dbReference type="HOGENOM" id="CLU_020695_4_0_1"/>
    <dbReference type="OMA" id="QHMRQME"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="88"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="187"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="390" mass="45114" checksum="FA59D4E212BA0859" modified="2015-03-04" version="1">MMGFHQPDETYFTEDYSHPPRSTQEHVKLSGLQRKEALANELSDQARSVYLDDIIQHMHHMESVTLPDVASMDIQHEIQWFMRPYLIDFLVEAHAAYQLLPETFFLTVNLLDRYCSRRVVYKRHYQLVGCAALLIAAKYADRKDRVPMIAELRKMCCKVYDEDMFTQMEWHVLNTLEWVIGHPTVDCFVRLAAENETIGDVQVEHMAWYLCELACYHKEFVSRKPSTMASASLALARGILGRPEAMESQSYEVRQTIYELSQKLESTSHVLFRKYASSHLSRVSNIVDNFLREQEVINRHASQQIIQTEETSIGKQMQTAGSYPGTPQRQNYYSNMSHGYMTPPITPEGEYFINSNNQKDFISGSQCPITPTPIPSHYTFPVGQNILSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NVQ4</accession>
    <name>A0A0B1NVQ4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004253">
        <property type="protein sequence ID" value="KHJ30437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NVQ4"/>
    <dbReference type="STRING" id="52586.A0A0B1NVQ4"/>
    <dbReference type="HOGENOM" id="CLU_015166_4_0_1"/>
    <dbReference type="OMA" id="NRRMYRG"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="143"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ30437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="349" mass="38490" checksum="D28176916B08A48E" modified="2015-03-04" version="1">MPFELNSPGCKSVGKKSDENVAQLQNSRNESSFTSNYRTEIAACIGSVISTFIAFPLDSVKTRMQTCQYKGYADCVRHTYKTEGYRGFIRGVVAPLLSVTIVRTVSFSIYQRSKYNYATWFKQNFGIDPLLHINTPGNYPNISTISCFGVAGATAGSVITLASCPFELTKLSAQVSNLDVDMKTGEYKSSDARKIAATYQNKGTFMTAKNIIKNRGILGLYTGFHLHLLRDTLGTATYFMTYESAKQVLTTVSPNKSSGNPLAIIIAGGVCGIASWALIYPIDSAKSIYQKNSLTTKKGEPVPRPPRIQFRNRRMYRGLGVSMGRSCLVNSVFFSAFEFIKKNVVDVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NW85</accession>
    <name>A0A0B1NW85_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003819">
        <property type="protein sequence ID" value="KHJ30647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NW85"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="17887" checksum="7C7B3C0F857FDEFA" modified="2015-03-04" version="1">MTDSMDISQESQAPSTESSNQPPPITPIPPIPNTPSPFASPSPPLNLQPPTKTTSGRQILKPVAPSKRPVTERISLNNSNQPNIGNAFLPKELAEIVATRQRHERAWHARLMICSTTMSNIESTLVNFKDDVEKEEVEAFKAYLRLAIANFAARRSYTQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYA7</accession>
    <name>A0A0B1NYA7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mitochondrial atpase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003414">
        <property type="protein sequence ID" value="KHJ30958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYA7"/>
    <dbReference type="HOGENOM" id="CLU_008681_7_0_1"/>
    <dbReference type="OMA" id="WMAKKLV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="98"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ30958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="650" mass="74495" checksum="B70D77A69892DAB7" modified="2015-03-04" version="1">MGGNQGSPFPRLAIHLQKVYLRLIDYSPGLDYVDRLRAINRLYENPQSKDDGEQLAVSGHPIRRNPLFSHLFSNEKKSNSLALTRVLTDYEEAINLQSPQGLLVHGEVGSGKSMLINLLADGLPTRKKHKWHFNTFMLETLAKLEQLRRSRSQSNFKDENSEHSLLWLAKDLIERSPILFIDEFQLPDRATSKILSQLLTIFFQLGGVLIATSNRMPDELLKSSGVEFTAPPINGVLNNFLGLSRKSQVSNLSINNEYAGFVEVLKARCEIWNMEGQRDWRRQEAEDMAREASQTIENSNENMVFLAQRDSNSVTQDSEEKRKSFSILPKNFFLKSMITEAEWQSVLKIISESDILTPNSWRTETLRVYARNVVVPRQLNGVTYWKFDELCEGPLGPADYISLASRYHTFVLDGVPVMTLVQKNEARRLITLLDALYEARCKLIVRAEAEPDSLFFPELSIPTQSSEILVENDNRPTIDDNRDSVYSETISEIYQDKILPFRPNISSYAKDSQSDYYSSKININLDSEPKIGCDSKQKPDKLQADFTKTSSFTGEDERFAYKRACSRLWEMCGAKWHSRSSPDWWRPLPTEIRTWEYSTTSRPSTSRELSFVNDIKMGEYLELDKPAGLQGHKHEQKECICNTYCQSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYR1</accession>
    <name>A0A0B1NYR1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003241">
        <property type="protein sequence ID" value="KHJ31123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYR1"/>
    <dbReference type="HOGENOM" id="CLU_056429_0_0_1"/>
    <dbReference type="OMA" id="TKAQFWT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="452" mass="51448" checksum="A0B6AE86747C32E6" modified="2015-03-04" version="1">MPSAYHTFKLVPMDETPSTNLPVSTPQVNQHPPQSSQPSQQVQSLSSPQNAHPPSHQTQPPPNPRPSDLPAQMTTPIQNAIQPMDSNMNPPPIPRNLITPTREMRESSVVSSGGTTRKPRQNLDEHDHLLMVKHCFDQREHYKEGTKAQFWTGVGNAFLRDTGKSLAQMSATVGRLVESRRRQIADWEAGVIPQKPGGELNDLLDKWMEFLKTEDGEAEAERMRQVDARRKLEEARKEARRQTAVTEIPTPPPNLPNPPYQRGQQEPPNYHGPPQSQHTTPTPRVYSGSYPHTPDATTFHSQPQGGEMVVVNGHQVPADINGYRGQKRKRHNESPLSHEMQVDQHQQRWQMQQQPPIIQQHPSSPYYPQVPIESVKRVIVEGQLTKEDWKDIMNNDTRLRALEIKLEKIETLVVQNNKFLFQLLQSRIKDGEGDPNQRPPVHLAAEFERDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NYZ1</accession>
    <name>A0A0B1NYZ1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003135">
        <property type="protein sequence ID" value="KHJ31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NYZ1"/>
    <dbReference type="STRING" id="52586.A0A0B1NYZ1"/>
    <dbReference type="HOGENOM" id="CLU_1548762_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055062">
        <property type="entry name" value="PsV_CP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22408">
        <property type="entry name" value="PsV_CP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PsV capsid protein C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="173" mass="19183" checksum="33F999D1D5BEDDC7" modified="2015-03-04" version="1">MWRIESTFKVGPPPAGNTGYGAQTVQSHETNLARWQFPSSDADVSIGFLFSPAKSFTLHPRLVEYSKKKKGSNNRNKIYAVEESSDELLNIVRHVNISDKYESDDSLCLNVPCDAAYAVPQVIKNPDWYLDTCVSKHNTPNLDVFIAGSLKLHKVSIKCADNNVLLLEGIGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZ75</accession>
    <name>A0A0B1NZ75_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative actin-like protein 6b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g4207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01005934">
        <property type="protein sequence ID" value="KHJ29991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZ75"/>
    <dbReference type="STRING" id="52586.A0A0B1NZ75"/>
    <dbReference type="HOGENOM" id="CLU_027965_9_0_1"/>
    <dbReference type="OMA" id="KSCGIHE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ29991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="110" mass="12269" checksum="252001684CA1E4F3" modified="2015-03-04" version="1">MNLSFADVLFKSISLSDIDLLKVLYSSVVISGGNTLLTGFNDRLLAEITKKTEPQTIRVKLVHPNGLTERIHSPWIGGSILASLGTFQRMWFSKQEYEDGGKMLINKKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZF8</accession>
    <name>A0A0B1NZF8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002988">
        <property type="protein sequence ID" value="KHJ31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZF8"/>
    <dbReference type="HOGENOM" id="CLU_2348244_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="101" mass="11339" checksum="78F0A926B333506B" modified="2015-03-04" version="1">MVEAEIKRVTQASPTTVRPHGKTKAGASLQLWLAHFPRPHAHKVGFRIFDESGLALVYKHRQNILKCKRCLGFHFTRGCSRALACANCASTMYLTFKCKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1NZG3</accession>
    <name>A0A0B1NZG3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g2168</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002607">
        <property type="protein sequence ID" value="KHJ31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1NZG3"/>
    <dbReference type="STRING" id="52586.A0A0B1NZG3"/>
    <dbReference type="HOGENOM" id="CLU_108081_1_2_1"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="99" mass="11575" checksum="04776F2FE0BEA4D9" modified="2015-03-04" version="1">MNNKQIVSSLYRRALKLSLDWAVHRNLWRGQALYIRSLFEANKSIQDPRMQQDLFRETEEILDEWKHPDPYSPPTAPGGSKYERNLPAPILSPPPYVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P000</accession>
    <name>A0A0B1P000_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative high-temperature-induced dauer-formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002453">
        <property type="protein sequence ID" value="KHJ31952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P000"/>
    <dbReference type="STRING" id="52586.A0A0B1P000"/>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="902" mass="101370" checksum="4D9938B7A75B797D" modified="2015-03-04" version="1">MGASDSKLVFKKGIFRLTEESVISADDPYWASFWELPESIEDIFSLFSPVDIRRTRDTALENLETLILAITSRLFILRHHPSFPDTEFAPERDALNCVRVLTRILPYIYEAESLREWEENFFWGVRRKRTRKAALARDVLFDESPEELAKLEAAGEEFEEIKPLAEELIDTLIDLLFFADFTLPRPLNSKLKVTYAIWKSGVGCNTSVGTSKEFESNRTEILRLLLTLTSQSMYLSINLLPVRGVKAISYIVTCPDKQVVLSFLCSLLNTSLKYNPISWRVPYNVQMFKDPKQILVTYALQLLLVILLYPIPENDISQVKKNFFRHFIGRLHRPQDFQFIVDGMTRILNQPLLASTSYIPGNQQQSKLTSEMIMLFWEMTQCNKRFRSFIIDTGRSHDFLVLILFYTIEFKIDSSKQGIVRMCVFILQTLSVEPNFGKNLRKKFEAQETLPPTIRLQNFNGTYADFLIQSIYNIITTSKGKLTAIYPALLAVINNVAAHLEDLSVSTSSKLLHLFASMSSPGFLLANESNHNLLHSLLDSINIILEHKFTENPNLVYAVIVNRKYFDALRSFTLESGQEKISRRSRQRKEFAFSSTNSISNLSCSNSTDSLLSTSMAHSRVPALSNVPEEDAAFAVGSDGEEDTDDEHIASIPAASPPTKDQSRASSVASESDNAVPVQMRRMSEKARGKLPAGMSSFSRQNSFTSLSSYSQKNVNTSGFEPTPAWVSKWVSELPLHTTLQIILQLHHLLSPNTRSTGEDIPSSLSSRLQNATITGVEPSPIRIQYFEWSTLSLGWYESLLWSFIFVSEIQVSKGTVGVWNGTEIKLFRVESTVASGPSLSSPRGAVDAVGNNIVSRIGGLGLRRATSAGVENRREDRPTISRTGTGDGQRFGLVNLRGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P062</accession>
    <name>A0A0B1P062_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01004754">
        <property type="protein sequence ID" value="KHJ30214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P062"/>
    <dbReference type="STRING" id="52586.A0A0B1P062"/>
    <dbReference type="HOGENOM" id="CLU_049841_1_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="212" mass="24381" checksum="54B6EE07B05B1636" modified="2015-03-04" version="1">MLPAKTFQALIAQLRTSISLSLKVQKSQKTAYYTADGYENDSFYTDRQYHEQKRSQTSSSSANNKEQSKTKFGKKACFVCSKEGCWSTRHSPEERMKSMADFKSKTLRLTDRKYTGPEIRQFLNDFEGLEPAQEIPDNFSHFHVTQDGEESDDLEDFFRTGIFFTDSQTETTSEAYSDFFPTLRGNVDGYTTVGSLRDKSIEHLLTQSRHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P087</accession>
    <name>A0A0B1P087_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative mboat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g0854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003734">
        <property type="protein sequence ID" value="KHJ30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P087"/>
    <dbReference type="STRING" id="52586.A0A0B1P087"/>
    <dbReference type="HOGENOM" id="CLU_011340_5_0_1"/>
    <dbReference type="OMA" id="WHGTRPG"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="532" mass="60527" checksum="484B64A038464CC0" modified="2015-03-04" version="1">MLPYISIPFEYVSSILGPSPDELKLMASFFLSFPLAGLLKRIPDNKPSWKNLYIISASLFYLVGLFDLWSGIRTLLISSTFTYCAAKYISGPFMPWIVFIFAMGHLSLNQLTRQFVNDPGVVDITGAQMILTIKLTSFAWNVADGQLPKNSLTGPQKEKALECLPSVLDFAGFIMFFPSLFAGPAFDFVDYKRWIEMEMFDIPIQGTDGNSSKLDSRKIKRVPQNFAPAMLKAASGVMWIILFMKLSTIYYPKFLTEDIYMTYRFPRRVWILHLLCFTTRLKYYGVWALTEAACILSGFGYAGINPATGKASWNNLRHVDPIGVETAQNTRAYLGSWNINTNNWLRNYIYLRVTPRGKKPGFRASLATFISSALWHGFYPGYYLSFILASFVQTVAKNFRRYLRPFFVDPSTSKPTSLKSLYDIFSYIVTQLSFSFITAPFIFLDLESSFLVWSRVYFYGIIGTAVSTIFFASPAKQMLIKKLDEMKRKEKLNTKFKSTSDTIVEPVLGIPSSIENDLKEIVQEFSNKSTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0N3</accession>
    <name>A0A0B1P0N3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003554">
        <property type="protein sequence ID" value="KHJ30825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0N3"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="162" mass="18082" checksum="812033C936297887" modified="2015-03-04" version="1">MSLNQPPLPPSPTATPHQPPPSKTLVNPIVENRPIIKPTPPSKRAAQYEAESEPKNEKNFGHAYLPKELANIIAARQRQERAWHIRLSICASIFSNIDSTLAIYKEDIEKEEADIIRKYLQKAIACLAASDNIPQPPKVPIESKPVKKKLKTTHSSDTNIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0T2</accession>
    <name>A0A0B1P0T2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquitin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003488">
        <property type="protein sequence ID" value="KHJ30890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0T2"/>
    <dbReference type="STRING" id="52586.A0A0B1P0T2"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ30890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="77" mass="8791" checksum="41D2B53DC21C4E8A" modified="2015-03-04" version="1">MLLKVRTLTGKEIELDVELDFTIEQIKERVEEKEGIPPVQQRLIFGGKQMSDDKKAKDYNLEPGCILHLVLALRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0W6</accession>
    <name>A0A0B1P0W6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002533">
        <property type="protein sequence ID" value="KHJ31858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0W6"/>
    <dbReference type="STRING" id="52586.A0A0B1P0W6"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OMA" id="EFWILLK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ31858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="516" mass="56004" checksum="E15BB9BDB0BFDBAB" modified="2015-03-04" version="1">MMDESTIKNLIPSLLPEAPKNCENLPNSSDSADERTTLLPPTLSSAKLSKGKDEFLYLLFEVSLLLRGSIPVVLAYALQNSLQTISVLIVGRLSPEALATASFSYMFAMSTAWLIALGGSTALDTLASSTFTGSKNSHHLGVLLQRAIIVLTVFYIPVAVLWFFSAPIFQILGQEEYISVNSSKFLSALIPGGLGYIYFETMKKYLQAQEIMHAGTYVLILTSPISACLNYIFVHTLGFGLLGAPIATGIAYWLSFALLVLYTRFFTHSNCWGGWSRSCLINIATFSRLAILGVVHIGTEWWAFEIVALAAGRLGTISLAAQSVIMTTDQVMNTIPFGIGVAASSRVGNLLGARNAVGAARAANAAAWLSILMGAIVLCILMLVKNFYAKIFNDDVAVIKLTAEVIPWVALFQIADGLNGSCGGSLRGMGRQHIGAIVNIVSYYMGALPLGIWLAFHGWGLSGLWIGQCIALYLVGICEWIIVSLSDWERQVKMAFERMDSPEVLQEEAQNLWNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P0Y8</accession>
    <name>A0A0B1P0Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mat1-1-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g2269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002210">
        <property type="protein sequence ID" value="KHJ32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P0Y8"/>
    <dbReference type="HOGENOM" id="CLU_967075_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="288" mass="33308" checksum="7B96AB94B953AC67" modified="2015-03-04" version="1">MSSGDDVQFLNTFMGSPQFSYSRWVRKRSTARTNKPVNSWIGFRTFYKKIFPGMPQKEASIHLKALWEQDPFKIKWTIISAAYSKIRDIVTKKDAPLDEFLNLVCPRIGILSVDEYLPQLNWISSVNEDGIIVYKQNKMPNLSNLPENILNTRMTDKDVVRFCAEKGFIDRSTTRKIKDAHPFIELGAIKSYFMTTQGQTPILPTEIGVNNDNSNQLEQDDCDVFYNLDSSILKISDPTKEQRSDQSIESNQDILKDNSFDYEDFFPKEISEYDIPDISYQLFLDNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P1D4</accession>
    <name>A0A0B1P1D4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003845">
        <property type="protein sequence ID" value="KHJ30634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P1D4"/>
    <dbReference type="HOGENOM" id="CLU_018153_5_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ30634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="205" mass="21981" checksum="BF225B132D5198CA" modified="2015-03-04" version="1">MIDSMDTSQESQALSTDSSNKPPPIPPIPPIPISPSPIASPPSPLNLQSLTKNTDGRQILKPVAPSKRPGTERTTLNNSNKINIGNAFLPKKLADIVAIRQRRERAWHARLIICTTAISSLESTLANFKDEIEVEEVAAFKAYLQLAIANFAAVDNSPIPPKIPSHSRPSKGSSHGLGKDKITAKKVAVAIPRSITNTESSLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P252</accession>
    <name>A0A0B1P252_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01003346">
        <property type="protein sequence ID" value="KHJ31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P252"/>
    <dbReference type="HOGENOM" id="CLU_1961205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002058831" evidence="1">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="128" mass="14408" checksum="F4C6371986633596" modified="2015-03-04" version="1">MHFHGFKCILTLLLLNLSSSSALNDLSYDERGLMISSAECSSRKYSADTIYNAVRTGVDAIAYANRIGFEPLVKTYTPKKGEVLGLNGPYYVHRFWNDGTDSQLFLRYALLPTFFNIRISGIEKSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2I1</accession>
    <name>A0A0B1P2I1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001761">
        <property type="protein sequence ID" value="KHJ32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2I1"/>
    <dbReference type="STRING" id="52586.A0A0B1P2I1"/>
    <dbReference type="HOGENOM" id="CLU_022625_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="623" mass="69632" checksum="4702188282298C46" modified="2015-03-04" version="1">MICTTVLSNIECTLANLTEDIEKEDAEAIKAYLRLAISNFAAADSSPSSPRKIDDNLTKKIAVATPQLILNQGPGRELNINAELPRIPKLSDNSWATVARKGQKKSRIDISTSARVAPANKTAIRPTNKDKTTSPTKAISDNRFFLRLPQEHEWHKLSPAGIPEVIVKKLLISPSLMRKIKPVNSGFALSPCSSEAREQILKAENGLFLSGAKLEPATNWVSILVPTDEIERVYSVRPVHLELYGRNNPEAPHRTWMALFAKAPRTGFRVFDESGIGMPFKKQHTLEFCKRCNGHHATKNCSRAPSCGNCGSTNHVENKCMAATKCRNCGGPHRSESRRCLVRPTRLGAPTEEQMKMYRQAGEREYQAIVRAREAETRAEAAMESTFEPIYSQSTVARPQAVTYKKKDPKNIHAMQIFPHSEITGDYCWVVINIITFLNLYKAPQYPAAVQPLLSWTPTGTVAAGDFNSVHWVWQPGVTKSYGQGEEIEIWAEMHNLSSLIIGEPTHLDRDECVTSDHYPISGIVHCQRQKEANKKGPLNVSDDQLPHFAKVVSQWLPSHTSLISIDEIEKATEEICRVIKEAIKAVGRHKNRGKGRSGLWWTSEYKAAYLQYHNAVTKSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2I8</accession>
    <name>A0A0B1P2I8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative f-box and wd domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g6184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002788">
        <property type="protein sequence ID" value="KHJ31555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2I8"/>
    <dbReference type="STRING" id="52586.A0A0B1P2I8"/>
    <dbReference type="HOGENOM" id="CLU_009186_0_0_1"/>
    <dbReference type="OMA" id="GPHPTYE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ31555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118654" checksum="8227A76F04FD6844" modified="2015-03-04" version="1">MQSKSNEISLCESNINLSSSQSTVYNHGTEKVQLRSPPSAISLKDESCLFKIFKDDHQENTSQADDAILLGQPNQVWSDKGITTRSNSMKVNFLLEDELLSSILENDKKAEFGIKSRSKSGRSFIPPFDQLPNEVLTVILSYLPASSITAVALVSKRFNVLVTTPHVWRAAFSRSFQGPSKPSEYANHYSVKCLTYPEESHSELRLFNRLTTRASWRSEYILRTRLLCSLERGKPGQLNSKSNDLSRTYNKPKNLNPILTYSSHLVAAVSHIHAVFDSEKKNPRFIHGASESNSVTMSDSVKGVIGEWRLSESELLSRFSEVWTGNPLFGLGDGPVGVPNSMDISLLHGIIIGEGIPAGRSFYQSCNEMRGRYLHQDKSENHEIGIPRIPESIEGVSAVWIAKSHSIPKMTDGLIGMLRGSTLGVVTAYSSGFDIGQTRLIPKGFATAKWVLSPGVPIIAFDIDDSYNSNRKASGRIWAVALNALGEVFYLSRTPSSKLLDKLLEIDVSDRYAWNVGRTVYWSMIENSRRVLRDDPYHTLEFKATHSPRSSPLHSNLSQAQLKKEALEIEKFFQYTPTQFRKAYDSWDMRRRLHVDFAGDDGSGAGEAVFVIKCGTLPKQKAEVMRMTKIGNKQVFPQPSPAQEIQLYSQTTPLRLDSSHFAASIANSTVEVGKECIFNKPNSEDNSLDPELQFLLDTEKNHETEPPKDFYLWQSTIFCLNDYSNIEITSSAIDMSTYALCTANEDPMSLAKFESEISYLNKERACESWSNSIPGNRARFLVVGTNIGSLIIWNMRGTLSQITSNTNELQPFRKIYTDSPEISSIAVSALYIVHGGSDGLVQAWDPLKLKSQPIRTLHSRSSRTHRRITRNESPSGPGSRTRAAGAIILDHDPLRLRGIVSIGTQLRYWSYSGTNDDITRKKRRQPHEGSSNSGSDRFSKNGRGAMRDYINTEQEYFRRDEIQISRENALLRGRFGVGICGLTEEETIRYAELISAEEFEKSKEHNNHKNSHLSDIDMPSQVSSKDDLANPDSGKRRNSIDNFSQDILEAIRLSLLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2V9</accession>
    <name>A0A0B1P2V9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001665">
        <property type="protein sequence ID" value="KHJ33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2V9"/>
    <dbReference type="STRING" id="52586.A0A0B1P2V9"/>
    <dbReference type="HOGENOM" id="CLU_1504543_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="179" mass="20670" checksum="406ED870B8F067FF" modified="2015-03-04" version="1">MGCQCTTYEVTEYLASFDLIKLKLEWVKSVPMKKRSQDAVNRFGIGVAGYCYLDEAVEIAKSLKAGGYCWDFHPATRSPEIISKYGNTNKNATNLMLECYTTEKLNYLKKIKRLAVYPVFDPAQTVYRTLTISMKYVATHKSLYMRKTSSTLFKFDNQFKFTVETIKPNLLRLKIYLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P2X7</accession>
    <name>A0A0B1P2X7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">EV44_g6164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002677">
        <property type="protein sequence ID" value="KHJ31680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P2X7"/>
    <dbReference type="STRING" id="52586.A0A0B1P2X7"/>
    <dbReference type="HOGENOM" id="CLU_005957_0_0_1"/>
    <dbReference type="OMA" id="HIVEISI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="796" mass="88222" checksum="C7DFE7C6A3A2159A" modified="2015-03-04" version="1">MSSSPLPSLCDLVTNIPHASARSSPVTSSPRIASAYFSGAAILSKTRSLTHAESSDSIESCKVVESKEIIINVESEDKNKKGKEACRQISLKSIDQSGIFTIVDDNLIVDLGENILGSHIADTLQSPSEKVNKSKKTGLRKVNETEAASNLKTRNYSTESKFCKQKHAQKKLKTKVEKTTQSRLRKGKVTKPSTLLTPASKSQETVGFAENLSKKPSNSNIIDVEEQIQECTPSICVKNAAITPFQNHIVEISISPDSSSKVDQNSKEKSKLFEEFVYVRSKKSLVEKKKSKEKVIGKRKLIELVKNCTPVPEKTKGKEKAFKKKSRTLTELSTSLFEEDQRPQPSLLHYLQSQGSEEGLFSNLKLSATSASEATIRMNSVASQSSKSALLSPESALKQVSKQDFVFGTSSQLAREESPTFLRDLQKAMQASNQLSDPFSRSPDLPPTMKCIKSSQSLWKAASRDSNGRLLDVELVDLAISPYKIDTVDSSPIFAGDPFLETENSLHTTNITSSTRLNSNDLIPTNDDQQQGNNNSTSVTPCSSPSKKSGAQSKVKYRQNLSNKISVQTAAEKIPNFASYTNAQLAKEISAYHFKPVKKREQMISLLQKCWEGKQEMKSKSSNTNTRIDVTAICVEKNDTLISSTKSKRETGEILIIEGRPSSSPQTRTPKKIQKKSEVKSLASEVKSEIRNPKNYLSTSELSPNSSSKLLFSHITQAVKNIIPSKEAKNPNWYEKILLYDPIVIEDLTIWLNTGALQKTNWDGEVDTKIVKKWCESKSICCLWRENLRGGARNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P372</accession>
    <name>A0A0B1P372_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001860">
        <property type="protein sequence ID" value="KHJ32723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P372"/>
    <dbReference type="HOGENOM" id="CLU_1161882_0_0_1"/>
    <dbReference type="OMA" id="HAIMACP"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27979" checksum="10B4FD8574A28058" modified="2015-03-04" version="1">MQHTGLANKSPVQRTIEKTSQSIKRQQHQRNTNIGSLSKEKDREEWSGICCGEESITRQKELGRIAAFQEWKDSWPHRHHNVNLRRRATADPVEWKAANIYTDKEGKKRMNLRGTPFSNHRNLKRAQSSVAIQIRSEHIGLKSYLYRRRVPGVDSPQCQCGYLSENVKHAIMACPLRAKGRAEVWRRAKNRSFEAMMNNPEDKARITQWILDQGWLEQCRLAGEVEELIKKRRVRRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3N7</accession>
    <name>A0A0B1P3N7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative developmental regulator flba protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g4943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002451">
        <property type="protein sequence ID" value="KHJ31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3N7"/>
    <dbReference type="STRING" id="52586.A0A0B1P3N7"/>
    <dbReference type="HOGENOM" id="CLU_013365_0_1_1"/>
    <dbReference type="OMA" id="DPGMRYL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="390"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="517"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="691" mass="77392" checksum="007633679DD78300" modified="2015-03-04" version="1">MALISFSRATKTATTSTSDPTLSSSSTTITSLPFNLAFNHWLSIIQAYTNGPESSSSPDPSLGVKLPQSESKVEATRGRSRSSPTRTITTSAIDGFNLSLKFTESLLRELFSSQRCSYDYSIVAPQHPEKFPHAIFQFNSLRLDSDSVSKSQPYTNLNLLSSGKSSESSSSPSNMHQTSSRLLRMTNDDRPFTRDFKDLFATLIVSLPLAPHRIRLTRIEHSFLSEEAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMSREMARSVCQRFLDARFIESADGKHSKDFPMKGALWQLTPKGVFVLERFCGKNGIQQKHVTELINSNRNTMQLVILERDPGSDKLSSDRSTIEVIFRRFVGQNGPNIKTNTSSSTSDSDSLNEYKDSVSGVRMTSERRIGSRMFTMTFTGRATTDWLMECCTTVDRLEATEIATLFLTHGLMTCVHIDRQYLAQFGGSKKEISTIFQPTKNAIYQITSKGKDIVEMKTRDFVPAGEKLASTSKSGACRDSSTQKLEKILNDAALRLLFRENLRETHCEENLSFYLDVDEFIRTCQKVIKFHSKASKSDPNSCSNLDSVKETMASAYGIYNAFLAPGSPNELNIDHMLRNQLATRMTKAVGQNGAMIESLEEVTKLFQEAQNSVFKLMASDSVPKFMKNPKYEQTLKNYDFDSILPKSQLEHNTSRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3T6</accession>
    <name>A0A0B1P3T6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative mitochondrial protein import protein mas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g2825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002402">
        <property type="protein sequence ID" value="KHJ32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3T6"/>
    <dbReference type="STRING" id="52586.A0A0B1P3T6"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_2_1"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140454">
        <property type="term" value="P:protein aggregate center assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="416" mass="46082" checksum="1489167A236E9E1D" modified="2015-03-04" version="1">MAKDTKLYDILQVQPNCTEAELKKAYKINALKHHPDKNRSNPNAAEKFKEISHAYEVLSDPQKRQIYDQYGEEGLEGGGAPNGMNAEDLFSQFFGGGSFGGGLGGMFGGQQQRGPPKARTIHHIHKVSLEDIYRGKVSKLALQKSVICQKCEGRGGKEGAVKKCSGCDGMGMKTMMRQMGPMIQRFQTQCSDCNGEGEIIREKDKCKVCHGKKTVVERKVLHVHVDKGVRSGTRIEFKGEGDQTPGVQPGDVVFEIEQKPHPRFQRKDDDLIYQAEIDLVTALAGGTLYIEHLDEQWLNIEILPGEVISPGSVKMLRGQGMPSHRHHHHGNMFVQFDVKFPEKNFASSPMAYETIKKLIPPSVTPILPPTDTMTETVYFEDVDPNDQARAHGATAMDEDDDDGHPAGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Y3</accession>
    <name>A0A0B1P3Y3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative monooxygenase fad-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EV44_g2989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001682">
        <property type="protein sequence ID" value="KHJ32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Y3"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Y3"/>
    <dbReference type="HOGENOM" id="CLU_009665_20_3_1"/>
    <dbReference type="OMA" id="YPQDRHE"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="177"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KHJ32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="588" mass="66414" checksum="80F261E3B28C2433" modified="2015-03-04" version="1">MDTSVLIVGAGPTGLMLALELSLHGVPFRIIDANVTAKPSYQSRALVIHSRTLELLARHDLAERFMSNGSFSDEVHIFLHRSFLWKIKNTRNLMGDTVYPDPVTVKQPIAEKYLEERLKDYGGKVEKGVSAENIVVDGDGEGVSVWIRRKKLAPGSNEDYKDGGEDKNQNEDQNEDQNEDQNEERLIKCKYVVGCDGMHSVVRSFAGINFEGTSYTDEYILADARVEWDNQIGSYFFIGRGLMAFLPLGGKDLYRIVCKRPSPRRSLFSAFWSHPPTLRQREPEIHEFNSSIAALLPSPIQIHNPTWLSTFRINSRLASTYNVGRLFLAGDAAHVHAPVGGQGMNCGIQDAVNLGWKLARVLRSTAPKSLLNSYEIERRKIADVTVRSTEFMFNIMATTNLLKIWLRDFIWCWILPYFGDSKSADKIRRRISQLSIRYRDSPIVNTSSKWKGKLRGGDRAPDGWLVNSQREQVTLHALCKKPADYLILFIGNESPNCLINKGDIRLLKACCSDLTVLNIYHSKDIQDIEFLDSYADPEGKLHALYQIDKPSYVLTRPDGYISSIGPLSSLTELKSWINTQTQPKNVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P3Y4</accession>
    <name>A0A0B1P3Y4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g3430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002966">
        <property type="protein sequence ID" value="KHJ31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P3Y4"/>
    <dbReference type="STRING" id="52586.A0A0B1P3Y4"/>
    <dbReference type="HOGENOM" id="CLU_687343_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="401" mass="45190" checksum="88A9EA2CC29ECA7E" modified="2015-03-04" version="1">MVAQPENHRSPMEILNDLKQGPLESVMNYFTKSQGVLHQLGVNKSNQQDPNSSTMRSLVIEMITSKFLTGLNDDRLRARSIERGAASAKTLEESFRIIKNVEKSMIDERKQMLLQKKPGNLGDSITVASYHGKNRPRRRQVEPLINTRIKDGPLDYMKILDKTKVEISLKDLAQMSPAARKHWKHGMSRVNDKRSRKKRRQAEISEVALKLPIEETQTDGSKKETRASNLEKSSAPQQIMTYKSFRVNAKVETVIAGKKKIILLDINSTHVDQGADLNLISDYLAKILKFQTIKLPKPILFGTAEGRLTNAIHFTKIRIGVSGVWRFAEALVLPPASGNPCSIILSLPWLFDVCGNLDIPTFTLKIGDITKGEKRVEVQTTQFKLGQNSRLRLMLADQKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4C2</accession>
    <name>A0A0B1P4C2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative importin-beta domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g5391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001369">
        <property type="protein sequence ID" value="KHJ33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4C2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4C2"/>
    <dbReference type="HOGENOM" id="CLU_003886_1_0_1"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1043" mass="118490" checksum="9DEAAF95DEE4FF33" modified="2015-03-04" version="1">MNFVMEFPGEATPLNAEVVSRVLMSATSSEQVKIQTATQQLQEWETQRGYFSLLQAAYLNKSLPTEVRYIAIIQLKNGVDKFWRKSAKNSISSDEKATIRSHLLDGGISEEERNLALQNALLLSKIVRIDYPNEWPEVLPNLIKIIRESRHSNRLRLQRGMLMLLQLVKELASARLRSLRSNFTLIAEELVFLLSEIYVENLVAWSTQKNELALNKDVADCSLISLKILRRLVIAGHEYPNKSSDIQRLWEYSQVQFGQFLEINSNQALKSSNDSKIMVEEHLLQLSKLHMMMAKQHPAAFALLPSSLELVRAYWGLITNFAESYSSHTLNFGMKTRSSENMRDSTTIMEKLCLKGLNILRACIRMVFNPLQSFKYRSPEIKVEQKKATDLIRTQLLSDSLIQQVANLLVTRLLVFRQIDLDAWEEDHEGWELKEEGAGAGSCWEFEIKSCSEKLFTDLVINYKTLLLNPLLSIFNSVANMGQGQDTILTKDAVYTAMGLSAPVIFKDFNFDTFLSSTIVNDVQTTGPGFKILRRRIAILIGQWVTIELSEKGRLMVYKIFQHLLNAEDETNDRVVQITAARNFKCVVDDFNFDAKGFVPFTSDILGRIMALAREVDAIETKIVLLDTIRSVANRLENNILPFADHIISMLASFWELAEEEYLLKQSIFSTLSTIVVSLQSASDRYYSLIIPLIANSISLTQNSKDHLLEDALDLWANVLETTSSTVSPEILSLADAILPLLEIGSDELRNILKVLEIYCILAPQHMLSDKDRRIRTLSYLSSFLGTSKREFIGLVTTIVEILIRAAEKLGGSEGVLLITQDLHSSGFLVEVFASLRDAWEAHQSSGPEKRYPKLDDAVETDYFTIIARLAVADPNVFANMLTSMGTIDETWSWLSTEWFHHFDCMTNMERRKLSCIALTRMLELPSPVLDINLAKLQDFFTIWTQTISELTFGSEDYSDCLIWKAASNANEKENMDVVRRREWAAADIVHKVSLHEFVKAKLAHVVEVCGGEKKFMDDWIINIDESVLKDYRALEITSSQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4G2</accession>
    <name>A0A0B1P4G2_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g5094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001592">
        <property type="protein sequence ID" value="KHJ33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4G2"/>
    <dbReference type="STRING" id="52586.A0A0B1P4G2"/>
    <dbReference type="HOGENOM" id="CLU_085418_2_1_1"/>
    <dbReference type="OMA" id="ITMQAET"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="187" mass="19709" checksum="A167154C4F097908" modified="2015-03-04" version="1">MSNKRASAQPPSLKPPTSLDSALIISEQASLTGKNLISLGSNTVIHPRCKLNSLNGSIIIGNCCIISERCRIGLQSEPTQADAEGVVIENSVVVEPGAIVEARRIGEGSVIEVNSKIGKGAILGKHCKVGPSCEVADGEVVPDYTVIFGSGQRRLDQSGAEAIKLKMLSKQIDVLKKLIPSSLAHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P4Q9</accession>
    <name>A0A0B1P4Q9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative arm repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002686">
        <property type="protein sequence ID" value="KHJ31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P4Q9"/>
    <dbReference type="STRING" id="52586.A0A0B1P4Q9"/>
    <dbReference type="HOGENOM" id="CLU_003417_0_0_1"/>
    <dbReference type="OMA" id="NKLGHPN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="651"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120109" checksum="6965B1D01FAF2D67" modified="2015-03-04" version="1">MGKRKFNSLEDSENLVVQNESSIPKLDEKVLSILTSKIEEGLEKQKLSENSLKSSKGDRTFRSIDLKYESNKELGSKLSKKKKISNTAAKESNRETKKNSTGKRKILDRKSSPSHYTSENVENDQKKILLREILALGGTEDDLELIASVGSHSEDEDKILQNSPPLLQKELQDELQSFINNIGIKTVAEENDEISDNSMANDSGQETSKINDSIDIGKNDRAQPEKNSSKKLVSSLSNEPNRLIFQARPDWHETSLPPLPVNKNFDSSAYNQVLINLKNHALSLLDADNQLYASKNMSSSSSQKFLTTIMASGTLSDKISALTLVVQESPVHTMKSFESLIGLAKKRSRGQAVIALAALKDLLGAGSMLPSNRRLRKFEDQPGLLGTLVENSVRHWNVGQKLPGSLSKVHLISWAYEDWLKDSYFEILKIMESWCNDEIVFARSRVVTYVYELLRDKPEQEANLLRLLVNKIGDPDRKIASRTSYLILQLQNSHPLMKPIIIRSIESEILLRPGQNLHAKYYAITTLNQTILSSKESEVAKTLLNIYFEHFVLVLKNTETPKFVPEESASNFNRDKRIQGGGSLPGKKANAKKIKEQQSKSISEETNEKMISALLTGVNRAFPFSKSDDITLESQMDTLFRITHSSNFNTSIQALILIEQLAISKNISVDRFYRTLYESLLDPRLITSSKHMLYLNLLYRALRSDFDVTRVKAFTKRMVQVITLHQPPFICGILYLLRELEEKFPGIQNLTRQPEQLESDEEVYFDIPENSDSDKEQKLMQTTNLVAKYDGKKRDPRYSNASNSCLWELIPFTTHFHPSVSLFARRLLSGEKMPPKPHLPSHSLSSFLDRFVYRNAKTAALKSKGNSIMQPLAGADGKTIFLSHKAVGVNQQPLNSETFWRQKIEDVAADEVFFHKYFSEIKNSKQATRKTVKSKAKISDGESDDGEDEIWQALVKSNPEIEGQDSDSETAMFDDSHSESSMENLDTDDDLENEGSIVSQLSFVDEYSNGSGVEIGANNVSEQTSDPKDDVKTSSKRKRTRDLPLFASVNDYASLLNDEPDEDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5F1</accession>
    <name>A0A0B1P5F1_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative orf21 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001147">
        <property type="protein sequence ID" value="KHJ33907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5F1"/>
    <dbReference type="STRING" id="52586.A0A0B1P5F1"/>
    <dbReference type="HOGENOM" id="CLU_078568_2_0_1"/>
    <dbReference type="OMA" id="SDWGNRT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="195" mass="22044" checksum="2CF15F855ED8B8D1" modified="2015-03-04" version="1">MLSLKRKNSSLDFHASSPKFTETNTSSVSQSTTWCLHPSRTRKRHRNSRPCDSVVYERTLSLLYSAQQSSSPLPQDPSNYKNRNQAFSHLSSINLSNQKLLSSLWNCPSNYFPQNPSRASPSADNTLTTKTSMLLCLQKVNCEDCDVPLNIEESAIDIREDDYTCATCGKYVCQSCSISYMDMERKCLICVDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5K4</accession>
    <name>A0A0B1P5K4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g2189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001360">
        <property type="protein sequence ID" value="KHJ33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5K4"/>
    <dbReference type="STRING" id="52586.A0A0B1P5K4"/>
    <dbReference type="HOGENOM" id="CLU_010811_4_1_1"/>
    <dbReference type="OMA" id="LPACTCK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="174"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="665" mass="74135" checksum="467770EA464FA658" modified="2015-03-04" version="1">MAHNQPHGRQPLHVKVDFTDRVGVRGGDSPDFIRSDSSPSSMSAPGSSRVLLPQHRSTAGQIQRPSLYSPSTVDSSEKLLPPQRPRGPRSYRDSPIESPSRTFSHLSSRRGSFDSEGSRDTSRHSPFVSIFDDSRAPSRAESDDDNLNTQTVSEKYNIMPSAGLLLFPEDVEKDDWLHNPDPNDKDNDGCDIFTKRGMANVGGLILICLGVLFLFIGYPVLTFVRSIIDPVSSACAADPNCLSDTLPLLKNQRTGLIDPDTPKSAFTKKSNDGKILKLVFSDEFNVDGRTFYEGDDAYFEAVDIWYGVTQDLEWYDPDAVTTSGGTLNLKFDAFQNHNLNYRSGMVQTWNKLCFKGGRLEASISLPGRGDIQGFWPGFWAMGNLGRPGYPATTDGTWPYSYWDKCDAGITANQSQSDGLSHLPGMRLPACTCSHEDHPTPGKSRSSPEIDALEASSGFMGPGEYGGATGLASQSFQAAPFDIFYQPDYEYIEIYDHNITSMNNYRGGPYQEALSGITWLNNEWYDGNAYQKYGFEYKPGPKGDISWFVGDEYTFKVDHRSTRPNGNIGQRIIPEEPMAIIINFGMSNSFATVFLHNLAQLMPATMRVDYIRIYQNENDELTCDPVGFPTTRYINSHPEPYKNPNLTLWSQTGYSWPKNRLLDKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P5U6</accession>
    <name>A0A0B1P5U6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001305">
        <property type="protein sequence ID" value="KHJ33648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P5U6"/>
    <dbReference type="STRING" id="52586.A0A0B1P5U6"/>
    <dbReference type="HOGENOM" id="CLU_016743_1_0_1"/>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="427"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="545" mass="59810" checksum="ADB511F7C37353DF" modified="2015-03-04" version="1">MPHAFSMPATGFQAIILCGPGSSFPTFTTNPDMNPKALLLIANRPMVWYPIEFCYRMGITNITLIAPPSSAPAIMVALNTNRHLTSFGLPKPNLLAPDGLDQNTNTAQIFRLPQVREIIKSDFIVLPCDIVCELGGESLLELWMGKETNIGSVAFTRGKSDRAETLKQKGIKGGLGIWYETKGELVVKGEGPDFIAISPLEVGPTPPSNSSLLRNTFQLVYSMPTDTLQDLIEEAKGFPIRHSLIRAHTQIRMLSSHRDAHIYIFPIWILDIINHNNKMDSIGEDLIGWWAKAGWQVGLGEKLGLKEALNRLELRSSEEKQRESSLGHEIIDPEGLSTTWITDIPKSEESDSNQTLKVPPILAYIHPVSNKLIRRVDSAPLLRSVSLQLAKLESIDMVGKDASSPFAHQSKIAHPQGIAPRTTITKSDCLIAENVIVEEKSVIKECVIGANCQIKSGARLIRCILMEDVIIGKGCKLTGCILGKHSNIGEDSILQDCEVQENLLIEAGTEDKDNKIMSSEGMEDTEETLDNFDGNSATALELGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P639</accession>
    <name>A0A0B1P639_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002297">
        <property type="protein sequence ID" value="KHJ32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P639"/>
    <dbReference type="STRING" id="52586.A0A0B1P639"/>
    <dbReference type="HOGENOM" id="CLU_011243_1_0_1"/>
    <dbReference type="OMA" id="PPGFRRY"/>
    <dbReference type="OrthoDB" id="4202871at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="585" mass="65240" checksum="4C9760DD7E413044" modified="2015-03-04" version="1">MATIEDLEAAFANHPSLNASLQDFEVTDSHSGFGLNARAMHSPKFSNVGRNSGIRSDTESDLVESVSGGLYSPPAWRWEGHSNRGSGFWKQGLSLTEASQLDSRENSPEVDLPNFDEDETLATAARTRLPTGSLSPEKRRSPSPEGIRAVASNFRRTFVDLPTQSENRHRGQRIVTPWEKKNNYIRFSVRAEVQHKTEPLEAGILFMKRKIELLTSSWLSLITSITVVLSSMLIIRSLFQPAAAPHVPDLVKVAGLARAFEPLIFYSENGIRQIGDLQATGIAVWDLGESVRVTNMTSAEMIVTQLDDLSESLKNLAIELSRFFANVDGDVDGILIVMDWARRELSQLQSSPPSSLTTAFDNMHMLLRRCGILETSIGTPTQLGAIAISIFGPSNQQRIEATLQKTFHEFLSVLEEAINTELTHSLALFSLFSAIDHRFHNLARTVARELNDQEDASELELSRLWSKIMGPDSKKLHKFEKNKNLLGNIRNMTFTNKGLLEDHNRKLLTLKANLENLRRKIVSPLLRGNESTIGIMDQIRGLEEVSGYLGGVREKQRGKLMEMLYGAGRNSRAPYKAANLGYDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P674</accession>
    <name>A0A0B1P674_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative translation initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001805">
        <property type="protein sequence ID" value="KHJ32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P674"/>
    <dbReference type="HOGENOM" id="CLU_1147914_0_0_1"/>
    <dbReference type="OMA" id="GTQTKAM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="242" mass="27507" checksum="0AA13C60BA27000D" modified="2015-03-04" version="1">MLNINGLTNRTTNSLRSFTYLIGCRKIKPVSRSTRATFFVSLNAWSHLFSQHHSAALSTSTTIKPKKLRLPRNEEITAESITVVDENGKISGPHQTKNFFEDFDLENKSLVTILEGNPEDGRPPLCRIYDRSLLRKKEINDLKNKGKIKVIPTKTLEISWTVDENDLNIKLRRLKEFLEKGCHVDLFLKAKKRGRPVTLDEGEKIVQRIQNTVKEAGGKENLSPVGDLLGTMEMSFSRKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P695</accession>
    <name>A0A0B1P695_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol phoshorylceramide synthase regulatory subunit kei1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g2448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002063">
        <property type="protein sequence ID" value="KHJ32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P695"/>
    <dbReference type="STRING" id="52586.A0A0B1P695"/>
    <dbReference type="HOGENOM" id="CLU_047267_0_0_1"/>
    <dbReference type="OMA" id="DQPVGFN"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35363" checksum="F04C0F170BFEE373" modified="2015-03-04" version="1">MGLLSRHLRIPRPTRFLGVMSLSTGVEMISIFMIFNKLTGFYGLLAILTGLRLSSLQITMYIYSCLAIVILAYLIPHIRKQSPFQCLLLSYFYLIDTVINTLFTCAFAIDWFLTITNGRSNSPTVAASNNMAKATTFKDHMYNISDIENVAKPTQSVTLVNEAIVYSVVSATATATPGSRFDETVPSVLLVVALTMTRVYFSLIVLAYVRQVLRRHAFLTSTPKLHLHTDGCIDNVPGDNLLTLGNPEKLGWKAKLGQLMIMMGEDYWIGDAKTDEAWAKGLDNRFRTSKMASEPPGTVERERRARSGTGPPMPLIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6C2</accession>
    <name>A0A0B1P6C2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01002033">
        <property type="protein sequence ID" value="KHJ32501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6C2"/>
    <dbReference type="STRING" id="52586.A0A0B1P6C2"/>
    <dbReference type="HOGENOM" id="CLU_1435428_0_0_1"/>
    <dbReference type="OMA" id="MFQNIAC"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="189" mass="20950" checksum="0094C7A8CFF78FB1" modified="2015-03-04" version="1">MFQNIACVLDDAITNNHSLPQHLQRPFREFIKDLNSVAHKHFECHVRGHNRPPLPYSTSTKTEQSANTGLKPQPKQLKVQSFTPSQPAITAATAIKSALPKQRAPLTPVQPCLTTRTQTRHKPKKAQEDNRLLVRVSSGHPALSMSPYAVMLQLNQHLGEKLIREIQVTKTGFAICPSSVAALESLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6D8</accession>
    <name>A0A0B1P6D8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EV44_g0324</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001230">
        <property type="protein sequence ID" value="KHJ33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6D8"/>
    <dbReference type="STRING" id="52586.A0A0B1P6D8"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OMA" id="TYLPQDM"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002080509" description="Probable aspartic-type endopeptidase OPSB" evidence="12">
        <location>
            <begin position="24"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="72"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KHJ33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="533" mass="56099" checksum="520754FDB340B06E" modified="2015-03-04" version="1">MKMSFKMNLLFLLTASLLMPSWCTTSSLHLDIQRNNVVRDAQLQKRATQNFHAKRGDSVVASLSNSLMQGLYFANVTVGTPGQNLALQIDTGSSDTWVPSSSATLCRSPKLGGCPDGSFSATQSSTFSLIGQGDFNISYVDNTGAVGDYFQDSFGIGDATLSGFEMGLALQTTIGIGIMGIGYNTSEANTNTDSGGNGTIYQNLPFALVSQGQVKSPAYSLWLNDLESSTGSILFGGVDTEKYMGKLTTVKVDPISRDYGITSFTVAFTSLSATSKSGTDQLTPPDFAVPAILDSGTTITLLPDKIAALIFEELGATPEDQLGAVLVPCDLAKNDGTLSYGFGGPDGPTIKVAVSDLVLPLTDNRGRSPKYKNGQTACQLGIEPAGSLPVLLGDTFLRSAYVVYDLINNQVALAETKFNVTKSNVVPFPSFGASIPDSKTISNEVQVLPTASSTPTVDDPQNPTGTNPLQVEQSPIPTQLNAKPGFLSTNDSKPNNAKKSLASTSLEPPAWPWTVVTCLSLALISVGGVFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6H0</accession>
    <name>A0A0B1P6H0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001712">
        <property type="protein sequence ID" value="KHJ32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6H0"/>
    <dbReference type="HOGENOM" id="CLU_2198946_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061912" evidence="2">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="108" mass="11825" checksum="D07CFD18224231E8" modified="2015-03-04" version="1">MRISYAISIIVLAIFSKAHEINQATHQTITARQVRNIIIPTVPPISIPTIPPLPTPSIPPIPTHTIPPIPGFPEIPPVPDAPKQPVFPQFPETPKVPNEPIIESEEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6K7</accession>
    <name>A0A0B1P6K7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g0902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001968">
        <property type="protein sequence ID" value="KHJ32586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6K7"/>
    <dbReference type="STRING" id="52586.A0A0B1P6K7"/>
    <dbReference type="HOGENOM" id="CLU_013808_3_0_1"/>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="547"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="546"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ32586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="625" mass="70316" checksum="3E5B37F9B9BD0387" modified="2015-03-04" version="1">MADASARLTALLAKISVIDNEEALDVARKALLSSKYNVDALHTIVVALLKLDRFKDALDALSRVDQKLSALCTLEEAYALYKTGKLSEAEALLQVTNKRGLKHVAAQVAYRAEKFIAALSEYRNLRSEKSIIEGEDNDLMVNISAIDAQLEWQTNGNRTDEEINKLTSGALNIFEISYNNACKYIAHKDFKTACDYLEKARELCEASDEMNEIEKKSEILPIMLQQAYVFTKLGKHDVAKNLLNLININELEPSSKIIAYNNNLVYSEMKNPFMAQRILSSIPSFPSFDQLFWYQTNILERNRIIADIKAQKYLGVARSTSKSILKYMPTISSHHNQLSVLNVAAYAKNNIGKAGIRAIIPLLEKRPNDVGLILTVVQLCVLINKPGHAIFRLENFLNGLEKSSLSEDQDVRFAPGLIALLISLYRLSGRKRPIKSILSKSATYWCQRNKPVNSMLYAACLSLLQSQDSDDLSAANELFKSMRHKKPDDKIALAGYIASCQSESNELASTEIDKLTPISTLISEIDIVALENNGVPSIHIPSIQSCKKRNKGNMDEEKLPAKKRKLSKKRMPKNYEEGKKVDPERWLAKKDRSDYRPRTKKGKKRVLDSMQGRNQSTNSRNKGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6L5</accession>
    <name>A0A0B1P6L5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alpha beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001678">
        <property type="protein sequence ID" value="KHJ33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6L5"/>
    <dbReference type="STRING" id="52586.A0A0B1P6L5"/>
    <dbReference type="HOGENOM" id="CLU_046066_1_3_1"/>
    <dbReference type="OMA" id="PWRDIPC"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="250" mass="26735" checksum="5EBC8322382AE846" modified="2015-03-04" version="1">MGILKPTIIIVPGSWQQVTAFRSFVSKLENEGFPTIAIKLPSVGSTSGPPLPGLDADIAAVREVVTQTIEKSQEVILLCHSYGGLVGSNAAKGLDVHTRSKQGSLGGIKKIIFLSAFVIPSGKSLFDLLGGQPLPWMDVQGDIVCAKKEKIAEIGFNDLSPEDAAKACLEMTHSSASTFLTPSNFEPWKNGISCDYVSTTEDNAIPHFQQEIMAKQLGPKANSVTLKSGHCAFLSIPDQLLKAIIRLSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6P4</accession>
    <name>A0A0B1P6P4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g6429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JNVN01000924">
        <property type="protein sequence ID" value="KHJ34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6P4"/>
    <dbReference type="STRING" id="52586.A0A0B1P6P4"/>
    <dbReference type="HOGENOM" id="CLU_002173_2_4_1"/>
    <dbReference type="OMA" id="HWLMTNR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="794"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1166" mass="134627" checksum="81195C797C909EF8" modified="2015-03-04" version="1">MFQNFTGNSRRPRQVNLSGQNLNPFATATGTRQTIVHAQQERQQRKLERARLNAATLIQRIWRGYKSRQKLSEARREEWDNLEVYNDSDNAHSILVAQLKLIVYFFVPQRKDDLDRIVRLSSKIIKSDSQTILALDEAHILLSKATVIILKALNTFLPEYPPNLLQFLVKIIDYQPFKFSKISKEYYTYLSHLISRNKALSINKSTLITALQTPLVEQDNSYDLVLDAYASFGIYFLTTPELEVFFGYWDDISSIINLNFLSSAIIRELSLDKADRHLDLEGKIWLLGHYTLFSRLQRNSIECSLYMKALLIQLVSLPEGLILKIDQDLETVQKESDSEESPRRLKPLPYFVRKQLLSLVAQESISNLLNRFSDESQNSPIDKEQNISSLACYILTLLRLFPRLEDEIRMWLYLGSMKTRSGAKLPILKYLWKVMRVSNIFSFIKTNSEAALISLRHAIEKHVDRSVFIEEDSEWHIVLLFLELYAFVLRFTDDEEFLNGNIPDVDLEKQSVSRIRQNALPLEDVKQLTEFLKNLSFSMYYNFGELIEGTKSLKDDKIGTHPGASSINSISQTVDSVISTKSILKASFAGILGESFKYVRTIATGVMCMLYERDSRRKFLPKDHWLMVSQFDMDGFIPAVILEEERQHEILENDGDEIDDSEDEILTTENHNSSLSGTSARHNFNSELARTTRSNLIRQRRLETIGSRLEVLQNMPFIIPFDTRVQIFQHFVFYDQIRRRKSYVDPDMWRRSILMRSRGLRDNEQLAHQVLRKHHAKIRRTNMFEDAYHHFYCLGDELKEPIQITFVDQFDTVEAGIDGGGVTKEFLTSVITEALCTKTSPRFFVTNDQNLLYPNPTALDEERENLRQEGYLESSQYWKDRIKDLLQQFEFLGRIIGKCLYEGILIDIGFASFFLLKWAASGLTYRVNINDIRDLDEKLYEGLLQLKNYNGNVESLSLDFTITDTFSDKNGQTIAITRDLIPNGSAVPVTNENRPLYVSYIARHRLQVQPYQQTQAFIKGLSDVINPAWISMFNRSELQILISGDSSEIDLEDLQRNTIYSGVYQIGDDGEEHETIKFFWNVMKALDDSDRRKVLKFITSSPRAPLLGFSKLNPLFSIRDSGGDDDRLPSTSTCVNLLKLPRYSSENILRQKLLYAVNSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P6Z9</accession>
    <name>A0A0B1P6Z9_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g0826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JNVN01001088">
        <property type="protein sequence ID" value="KHJ34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P6Z9"/>
    <dbReference type="STRING" id="52586.A0A0B1P6Z9"/>
    <dbReference type="HOGENOM" id="CLU_018316_0_2_1"/>
    <dbReference type="OMA" id="SAWRFEN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="224" mass="25480" checksum="66CC3EBB47A0FE99" modified="2015-03-04" version="1">MFFAKQTIQNACGTQALLSVLLNKDNEIDVGSQLREFKDFTAALPAEFKGEALSNSQLIRDVHNSFSKSSPFVDETEMPTEDGDAYHFIAYTSINNILYELDGLHSAPISHGFSTAEEFADKVVQVLQRRIARYPAHEIRFNLLAMVKDLRVKAHEIGDQEMLSREEQKRSAWRFENALRRHNFLGFTGELLKEIASAKLKENPDAYGNWLESARQDTIQNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A3</accession>
    <name>A0A0B1P7A3_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g6326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="JNVN01001564">
        <property type="protein sequence ID" value="KHJ33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A3"/>
    <dbReference type="STRING" id="52586.A0A0B1P7A3"/>
    <dbReference type="HOGENOM" id="CLU_029393_1_1_1"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CYTH" evidence="10">
        <location>
            <begin position="401"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="460" mass="52197" checksum="2315E9D74081CDF4" modified="2015-03-04" version="1">MKFKSFLLTVRRPISVNSSLLVITNRNTYGSKRWSSSPSQKPGATGVRFPGALESEFTNKLIFEHPSSYQVIPTFRAMNQDGDIVVDLSSFITSFSDDLALKMYHNMIEISIMDTIMFDAQRQGRISFYITCHGEEGISVGSASVLEKEDVIFSQYRESGVLKQRGFSIEEFMSQLFANRKDSGRGRNMPVHYGSRALNIHTISSPLATQIPHAAGAAYALKMQRLIDPNIPPRVVVCYFGEGAASEGDFHAALNIAATRSCPVLFICRNNGYAISTPTLEQYRGDGIASRGISYGIETIRVDGNDVVAVREVTARARNLALKDNCRPILIEAMSYRVSHHSTSDDSFAYRARVEVEDWKLRDNPITRLRKYLEKRGIWNDEQEENTRIRLKKEILTAFARAEEEKKPSLRYMFEDIYEELTPETRAQMLQLKELLDNYPEEYDISKFEGSKESLRIRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7A8</accession>
    <name>A0A0B1P7A8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g1025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="JNVN01001822">
        <property type="protein sequence ID" value="KHJ32776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7A8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7A8"/>
    <dbReference type="HOGENOM" id="CLU_054611_0_1_1"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ32776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="34508" checksum="FF872284DBBA76DF" modified="2015-03-04" version="1">MALSMHSHSGQFCPGHAKDSLEECINAAILKGFQLFALTEHMPRDSHQDLYPEEILAEDNVSKLHSRHSDYLAEALNLREKYKDQIKILIGFECEWIRASYGPLIKQLAADPAIDYFIGSVHHVHEIPIDYDRSFYFQAREKAGGTDARLFEDYFDAQYQMLIEVQPRVIGHFDLIRLLSDRRDLSLTDLEDVWTRILRNLRVILEKDALLEVNSSGLRKGLKEPYPMRCICEAFLKMGGKLTLSDDSHGIAQVGTCFPEALEYIASLGTKEIWCLDRNDGDKNLSFRSISVQDIQASLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M4</accession>
    <name>A0A0B1P7M4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ppe family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g0547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001517">
        <property type="protein sequence ID" value="KHJ33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7M4"/>
    <dbReference type="STRING" id="52586.A0A0B1P7M4"/>
    <dbReference type="HOGENOM" id="CLU_099565_0_0_1"/>
    <dbReference type="OMA" id="MHYIQIL"/>
    <dbReference type="OrthoDB" id="2118427at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002061946" evidence="2">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="213" mass="21895" checksum="5A5ABCA60024ACAD" modified="2015-03-04" version="1">MHYIQILSFLACAQVAFANPILQQSRAKSAANDATQSVKAASNSTGNNITNDSVQRAADGFAQDAGIVSNAINAMTSMTDQNAIKATAQRAFDAESDEDNQRKVLAAAAGTAGNSANSKIQKYTPTVLNGLKAITKDPSPDSVQKNTQMMEDPRNANILPSITQLSNAALDAMGLAQTAPELKMTTGASGNGDSTNGGSGNNGGNSQKGSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7M6</accession>
    <name>A0A0B1P7M6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g0848</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Preautophagosomal structure membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000742">
        <property type="protein sequence ID" value="KHJ34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7M6"/>
    <dbReference type="STRING" id="52586.A0A0B1P7M6"/>
    <dbReference type="HOGENOM" id="CLU_051894_2_0_1"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000004">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="5 9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="12">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="11">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="10">
        <location>
            <begin position="167"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="281" mass="31340" checksum="83DAD7ABAA02118E" modified="2015-03-04" version="1">MQSFIWGSTIPLCIRHDTSAIPYLVNVPRNSYLPLLLPRLNSFFRHNFGGRGVKEDANVNNKFVNATSFSYDGILLKNLPVGLLYDLYQPLLPWQLSLGNGPLYEMHDTFINSVKEADFVRNGTAKGIMSMSKENSTQLWNSVQDNDFRAFHKIHQVLLNPPTPLKHIPLRLYVPSVPNATTGFSSFNVIQMLVPPITASQEIQSVGSALSLTLPTLFPSRGEEILAQPILHGAPVPFHAPLIDLMKEAAYADGWLHVCIRMLDRQIIVLPKSTVQGSIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7X2</accession>
    <name>A0A0B1P7X2_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g3137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000939">
        <property type="protein sequence ID" value="KHJ34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7X2"/>
    <dbReference type="STRING" id="52586.A0A0B1P7X2"/>
    <dbReference type="HOGENOM" id="CLU_847839_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="328" mass="37924" checksum="7CEB1E7D8EE76A68" modified="2015-03-04" version="1">MSGKQVQQQENMGVSNSTFFSTVLKDNPIRTVALNNVVKLTGQATYETWSIMMITIWRKMGLLELIVDGIKPILNARKDEVRAYTVLYNAAIGTFLQVIHTDILKVLLDKSELHLMWTYLVTEYKRDTAYALVYQLGNLCQLFTAYDSGKTLSEFIQMFKGEWYKVYRLARDSNEEHHQEFANFLLKDLVKRDSLLDFLGRHKKNVVDNLTTKTDLTFAVVKQRLLDIDFEEVSHTALAAGSITSKKPVLTRRSGIRKTITCSYCRKHHPKSNLNHKWYKCLKLKEFNEKKRKNNLNKGQLMNNSNEAMITSTSEENDFQFSRNVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P7Y8</accession>
    <name>A0A0B1P7Y8_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative effector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001835">
        <property type="protein sequence ID" value="KHJ32764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P7Y8"/>
    <dbReference type="STRING" id="52586.A0A0B1P7Y8"/>
    <dbReference type="HOGENOM" id="CLU_1078461_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ32764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="258" mass="28897" checksum="7A7A2FC218FAB0FE" modified="2015-03-04" version="1">MDTFLALPSGIALVAPSHVDAQDLLAAYQIFQPLTGAAQVERQEMRHTFLLDPVPQYGYNTAGLPEPLSLVGIKNELSLVSIDTKSIYAMNWTKRSSESTHNDDTLRIISSVKAISNIPSLVRLFARTARLRLAEERSRIQIGDRCHEFHNINSITRKSRCGLCAEDSHSGTCQKTKKCLNCAEPYSSDHLECPARPISWNGVFIRPNKKRFRTIRNAGHKMWCATNQQPKSTENTPPVQKTAVTEQLVARRDPSNPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P883</accession>
    <name>A0A0B1P883_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative histone acetyltransferase spt10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g2463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000855">
        <property type="protein sequence ID" value="KHJ34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P883"/>
    <dbReference type="STRING" id="52586.A0A0B1P883"/>
    <dbReference type="HOGENOM" id="CLU_013985_42_0_1"/>
    <dbReference type="OMA" id="THEAMSH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="55981" checksum="DD15E630B8DCF509" modified="2015-03-04" version="1">MLDDPFAPVTHRNSGVAPYPHAQDVFVRHVTLRDHITTASIIPFASQHQVPRSLLLFLTEQFNIEISNGDTYPFSELMTVEQFTAYWFENFGAVMFFGSFSSCDELSEERDWPKEVLGTFYIKPNYPGRASHISNAGFFVTPPARNRGVGRLLGEAYVNWAPKLGYTYSVFNLVFETNIASCRIWDSLGFKRIGRIKGAGNLRSYPGKFIDAIIFGRDLGLENEDIVTEERFEKIKFYLKHGRYPAGADRSEKSRLRSAATHYKFEPDTDKLMLKDKEVISDAQQQYEIARDVHLQQHGGINKTTAIINEKYHWVRIKETVSQVIRNCAYCKELGKCHNISPDSASRHVSHRSTPKPVMLAQPYSYTTMDSSSIALIEGPKNSRLQIQGLNDQIYTPGHGTISPLVLNHNPSSNDLDSLKCEKCDSNSSVPSESTTYLTLESQISDSGSLTDKERLRNSNLLDSLEIQDQTNPFIDNEIENVSLDSILGVDNKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8C0</accession>
    <name>A0A0B1P8C0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000840">
        <property type="protein sequence ID" value="KHJ34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8C0"/>
    <dbReference type="HOGENOM" id="CLU_018153_4_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="196" mass="21927" checksum="3457062A38AFEE74" modified="2015-03-04" version="1">MLMNEIERVSSKRPAHVKLYGTTNPEAPHRAWLALFSEAPRCGFRVFDESGIMKIFKKKLPIEFCKRCNGHHNIRNCSRAPSCGNCGSTMHAQDVCKVLTKCRNCGGPHRSDSHRCLARPTRYGKPTKEQLDAYRRAGDREYQAVVRANAAEARAAIAENTEGANETPSRSQETIISVENPNETPVQTQAGEEMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8F7</accession>
    <name>A0A0B1P8F7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000594">
        <property type="protein sequence ID" value="KHJ34977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8F7"/>
    <dbReference type="HOGENOM" id="CLU_056572_0_0_1"/>
    <dbReference type="OMA" id="NIWENID"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="283" mass="31561" checksum="82CAF79923AEE618" modified="2015-03-04" version="1">MSKVTTENVKQSREPPPPLFLGSPSLSTSYVSLSSVNSRHSTDKMKEMSVPRVPFLRQASQFSQQVSFKSSNGTPTSDQSSVMSQHPFPRYKQEMGGKKIVDNPDDAQWLEMQRTLKEVEMSATKGIHVFGTQHSKALEDLRNAQIELANAWARSESEEAIEDGDRLGKGIPGISLNFNSDGKPSRPTASSANVRLGNALDPSESESERTKEKEFDADIIMARKRREANDRYFQRLNDNVLDVVSKLEEVSSSIRAVARESKNIWENIDVEKSNKSVHDSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8Q3</accession>
    <name>A0A0B1P8Q3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mrna cleavage factor complex component pcf11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001651">
        <property type="protein sequence ID" value="KHJ33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8Q3"/>
    <dbReference type="STRING" id="52586.A0A0B1P8Q3"/>
    <dbReference type="HOGENOM" id="CLU_015606_0_0_1"/>
    <dbReference type="OMA" id="ARSDFAN"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="725" mass="81053" checksum="66374B050E43C007" modified="2015-03-04" version="1">MTSSMSDEVAEDYRIALEALTLNSRYEISNLTVIAKENTEHALAISEALKNHIKTTSPNKKLPSFYVLDSVVKNVGTPYTLFFGRQLYATFMEAYALVDNNVRRKMDEMLKTWKEPVPGSMDTRPVFPPEVTRPIENALIKAKTSFLQAHQEHMRTQQQLTGRGRQIPPQIPYRETPTPPNVFRQSQQQQLQNISSGFPKQQYFLPDNQQLSSQPNGHSYPGLPNGHQYPVSNIGQHYPDPRSDQNYPNAQSFPQYPNNGLQYNSQPNIQSYPNIPNSNRPFILPTVPLNQPYIQPTSSHSWQDYASQRFSAGETSIDSLNGDVDRLIMESKAAWARNMQDTAVSTRLKALLDLQSILQNQKLPPDQISLIRTQVAQLSEACKTQSMIQAPRTPTLATSVQTPQTSVDSLLGPGALAALMARQNTIPPITSQSLTQFPSPQAPSSQPSYHPATHITNPNASTDSNVALLEKLRAAGIIGRTPATSVTNSFNFLPTVKVPPLININPSPRIPVVDTANDLVLKSASLKIPRPHLISNLYEKLGAPCSQCGRRFQADVEGKKKKEAHMDWHFRVRRRMEEAELRGQHRSWYVDELDWIKSREIDLECSGAAPDLGTTVAINDTPKDSKLEYIPVPDDAASSNSLCPICQEKFEMNWLDEAQEFVWMDARTIGEKTYHASCYAEVSKNIKSQNIVGTPETTITVLGKRKADDDLSMTIKTKIKNEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P8R7</accession>
    <name>A0A0B1P8R7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative s-adenosyl-l-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g6233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001524">
        <property type="protein sequence ID" value="KHJ33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P8R7"/>
    <dbReference type="SMR" id="A0A0B1P8R7"/>
    <dbReference type="STRING" id="52586.A0A0B1P8R7"/>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OMA" id="SIIEAVW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="517" mass="58043" checksum="EF37435D34878AAF" modified="2015-03-04" version="1">MKIIIRLPRVVFTHRLANGSLKPSRRRSPCQKVNPREWELKSVDCSTSHNYEPAPRIEKVIKPKDNGNISISNFAKSEESASLLLKLAHTISKETTKLDRCLKNDGAPELGFSIDSPLEFPIQSVEVEKSRARIIRATEELSALVMGPADSLRWMAWGHSNSLSLHAIYHYKIVKSFPIHETATFAQISKRVGLSELNVRRFLRHAMTNRIFKEVEPGLVAHTAASRLLAENSKMDDWVGFCVEEMWQAAAMTVSALERNPQADDPKQTGFCLSNSTTDVETMFTTFEKSPFRSARMGGAMHSLTDGPGYELTHLLSSPVWLALNKCQALVVDIGGSHGFVSIALASKFPQLRFIVQDTPATIASASPLSKDLSKRIQFQIHDFHTIQKVKGADVYFFRWIFHNHSDRLAIPMLRNLIPALKNGARVIINDYCLPEPASMATKSSCIDPIEEKILRSMDLAMLSLLNSQERDETEYRMLFKSADKRFRFIGVHNSVGSSMALIEAIWAGQDFCQVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P903</accession>
    <name>A0A0B1P903_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">EV44_g2052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001433">
        <property type="protein sequence ID" value="KHJ33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P903"/>
    <dbReference type="STRING" id="52586.A0A0B1P903"/>
    <dbReference type="HOGENOM" id="CLU_031132_0_0_1"/>
    <dbReference type="OMA" id="NCPWILR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="222"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="429" mass="49766" checksum="9FC40A066F696D14" modified="2015-03-04" version="1">MSCIVKETNLLPKLVCYLDRHLIYPLLQFVADQEEEPSIETIRAMFELLKKTNMTDYVSSLYCQLEGIEEPPKEFNEKKVQIVAELGRFVEESQKITDLLGREDVVNNFRSDKVANMDFLKSQHGVTIEEVNILYDFGNFEYSCGNYQSAADLLYKFRVLSTDNDKVAAATWGKLASDILLTNWESSMEEIQKVKELIDTKLFNNPLAQLIHRTWLIHWALFPFFNYDSARDTICELLFSAPIINTIQTSCPWILRYLTVAVITNRSRTRNIGQYHKRLNDIIQIVEQEIYEYSDPITDFVKALYIDFDFEEAQKKLTEAEEVLRTDFFLALKSDSFIDAARHLISESYCKIHHRIDIKDLSARLGLNQDEGEKWIVNLIRDTRLDAKIDYKEGTVLMNHPPSSVYQQVIERTKGGFFRTQVLSAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P935</accession>
    <name>A0A0B1P935_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative swi snf family dna-dependent atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g5746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001208">
        <property type="protein sequence ID" value="KHJ33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P935"/>
    <dbReference type="STRING" id="52586.A0A0B1P935"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_0_1"/>
    <dbReference type="OMA" id="HRERAIQ"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16564">
        <property type="entry name" value="RING-HC_RNF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="435"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="785"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1156" mass="130951" checksum="0146C69CB2374F40" modified="2015-03-04" version="1">MSLSEQALSTVQERILHVREEINLHLALLESVDASVSNSQALEKELRGQLRELQRQYDNLKQNIDPTGQKTAAPSITSDHILDESAIFNLSREYYPIDSDASQEIKQSENGIGLEVLKHQNRKRQYSEYSEAAALSTRNVAKFQRLTLNSPVNRQKTKSLIVLDSTDESNDHSTELLVRQQKEIEERIQLERLDEQYARRLQSELESNYTDLNDQCHSYMRSPRAKKKITLNSSSSSCSNSKSNYESLKVRQPSIFDFSHQCNGESSNDANNTILIDLDDDSDVKSEITLDSLSSESEAEVEFVRSNTISTGAKINYQDGPKFMFESPKFAMDNVSNGFSHQNSLPSIYQKTPRSLYHFKANNISSKETISNHDGVPLPKSFINTEVKNSEINDECKELAKNIRLDTETRREETPQGLVHPLYEHQKIALFWLKSKEESAIKGGILADDMGLGKTISALALVLSRPSTKSSRKTTLIVGPVALIRQWEREIRVKIRKKWRLSTIVVHGSKKYAWDDISHYDIALTTYGTLSSEFRRLIKWKESHPGQNFDESILKKKFPLVGPKSQFYRIILDEAQSIKNKNTVSAKACFHLNATYRICLTGTPMMNNVTELYSVILFLRVKPYNEWSRFNSDFGILSRPAASESSISSAMKKLQALLKAILLRRTKNTLIDGKPIISLPPKIEKIQHVVFNDDESAFYNALESKSKIQFNNYLAAGSIGKNYSNILVLLLRLRQACCHPHLIYDFDQASGTESHLKKDEMIELAKSLSPDVVERLLNCDGAFECPICYDGVENPRIILPCGHDTCTECLAKITDQQTLLSSSEYESSNEIVSKCPSCRGPLVLSKVIDYASFKNVHGAGNAENQNKKVVSDTESDSETESDDSETEYEDVGNLKGDLRDFIVSGPIDGQGHGKAASDFLILSKRKNKGKGKSSKFFRPENKHNDNEKKIHLSLAMLKQEANKSAINRKRYMKYLKSHWQPSAKITKCMELIRKFLDEKQKILIFSQFVSLLDLLQVPIEEERWNYLRYDGSMSADLRHFAIEKFSDSTTHNIMLLSLKAGNAGLNLISASRVIILDPFWNPFIEMQAVDRAHRIGQQNTVEIHRILIKSTVEDRIVELQERKRKLVDMALDEGAARSLGRLNEAQLVFLFGGGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P938</accession>
    <name>A0A0B1P938_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g5078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01001206">
        <property type="protein sequence ID" value="KHJ33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P938"/>
    <dbReference type="STRING" id="52586.A0A0B1P938"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="461" mass="51997" checksum="0A69904F1B476104" modified="2015-03-04" version="1">MENVANILAGKYPAKLHVQRVIQWMKERNTVTAGIIYLEGQKTKLLEDNDGEAPFRQRRYFYYLTGCPLPDSYFTYDIGSNKSVLYIPPVNPESVMWSGLPLSCTEALSLYDVDEVRTTDVAKDFLLQSEFSSLWTIQNQASDIMKFLELDNRSYIVNDSLLKEAIGECRVIKDEYEIALMKKASTISVAAHHAAIKAAKFAQNERELLGIFLEKCISLGAKEQAYSPIVASGTAAATLHYVKNDQPLSRKLNILLDAGAEYNCYASDITRTFPINGRFTPESKAVYDIVLEMQISSIQQLRKDVLWDQVHLGAHRIVIDGLHKLGIFQGDKTSIYDARTSVAFFPHGLGHYLGMDTHDTGGHPNYNDEDPYFRYLRVRGKLPTGSVITVEPGLYFCRFIIEPYLANPIHAKFINTEVLNKYWEVGGIRIEDNVLITETGHENLTSAVKTVEDMEKIQASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P974</accession>
    <name>A0A0B1P974_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g5566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001383">
        <property type="protein sequence ID" value="KHJ33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P974"/>
    <dbReference type="STRING" id="52586.A0A0B1P974"/>
    <dbReference type="HOGENOM" id="CLU_037769_2_1_1"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="367" mass="42104" checksum="BD49E6B02C5A2C3A" modified="2015-03-04" version="1">MSSDLEELVSFISHGNTQIRQSALELLVPYSCKEPNIFKTDQLLPVKRLAFLVRDYKQISKNALTILMNLSQDSEVQKLLTCNDDFLQTLFKQLANPNEPNIAEITMLLSNLSKNDKFKRKFLNQNLVSKPYLSAGKPIDFILDIFVKGTIDSKDQVSNYDYLSYVFSDLAILPEIRKHLLTPQSYDQIIPFSKLIVFTSHESRIRRLGVAGAIKNVCFEVESHQILLDTSENGLRLLPYLLLPLMDGEEYDTYDSEGMLEECQLLPDSKKREDDPMILSLHLESLLLLTSTRAGRDQLRKIRVYPIIRQLHLAIESHCVKDICDRLVNVLMRDEEDTKEESGNKSAIVNLVEHFPDKDDEDKILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9D6</accession>
    <name>A0A0B1P9D6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dna repair protein rad57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g5539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001350">
        <property type="protein sequence ID" value="KHJ33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9D6"/>
    <dbReference type="STRING" id="52586.A0A0B1P9D6"/>
    <dbReference type="HOGENOM" id="CLU_146827_0_0_1"/>
    <dbReference type="OMA" id="HDWACIS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="137" mass="14686" checksum="6EFB34A04F238615" modified="2015-03-04" version="1">MTDLGAILPSFPVQKYSHLLPSLEKHLVTTVDLITLDSLDIAKRACLPVLDVKKLCSAVLDAFHFNLGITEDSSTSPGYGILRKTGNQIVNNSTKISTLDDGLDNGLRGGIPTGSITEITGERYIDPLTSHCFTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9H4</accession>
    <name>A0A0B1P9H4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative xpg domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g0803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000629">
        <property type="protein sequence ID" value="KHJ34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9H4"/>
    <dbReference type="STRING" id="52586.A0A0B1P9H4"/>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="501"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="748" mass="84276" checksum="55AF2B61F8111C8F" modified="2015-03-04" version="1">MPLNDPEFSFGFQHNNSTPTYASTPLSELKNAVIGVEATAYLQNMIDSGPAHEPLLAALGGDPIGLKYHLELELDKWSDNNLVPLFVFDGQSIVGKDEMTLKSSQAALLKTQLAWNMYGDHQPNQAVKTFGSSGSIRAHELYHLLQDVLCRRGLVFQIAPFSACAQLIYLAELEVSGRAYIDGLMGSKELLLYDRSYEAVIICPPSVDDWENKHFRGIFRSELLEKLGIGSKMLDDALLMCGTSFLPPFPPLQFENTIPHQPFTLVDAVNLLRGSEKSIVGACRQFADILEKHDPKWLDKFWKAKIGILHAIIVQENGQVISRDYANLTSDNNDYLGLRLPPELYYYLSRALVGPRILNYFVSLESIIFPTLDGIVSEEYKRLITKTIIPLKETAAALVASRIHRAFQNKSVSIRFWFDSDLKQSLLHKSVLEQANRKADTWGVENSQLQTWAKMTNTKAGTISFAVVSLLVNGAPAASKSSVKVIGLKSKPEILSNTLYRFLHLRDYVDDLHELTAWGKALAVTLKLVQPIIRKYDDIHHIEEAAFLAFEMIRFGHLNSRNRHPELIGGALRGSEEDKASCMLVGRTACLLKLRHQNLGYTGPLSKNYLAFISLIKTIQEADRDILEAAVVSMFLSNQISREERHDCGDIGRSLPLSHSTNTIFGIAVTTYLDDFIKLNWTKAEREENKPVFAKKFIPHSTKLVEDLTVAFEFFDAVYEGIKSLREEMPIVEKEAWHKAYKYLNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9J1</accession>
    <name>A0A0B1P9J1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EV44_g6392</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000430">
        <property type="protein sequence ID" value="KHJ35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9J1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9J1"/>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="OMA" id="NKAFDCR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="443"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KHJ35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="649" mass="74441" checksum="80C44837E7469C27" modified="2015-03-04" version="1">MVEEKSQVEPGKDASSEPYKAKSIPTRNDDQQENLDRKDKVREKNQSKSKDRRRNFSGGESGRGHGSRHHNGRQYKGEFSRAEWSRDKIGKRKMYDDNNSTQRKKIDRGDEDAEKASQLIKNEVSSEERRPKRKVAVMIGYAGTGYKGMQINVEEKTIEGDIFKAFVASGAISKANADDPKKSSLVRCARTDKGVHAAGNVISLKLIVEDNDIVQKINENLPSQIRVWGYERTSGGFSCYQSCDSRWYEYMIPSYSFLPPHPNSYLGRKLIESATSEGYLEKYLEEQEDVSTFWENAMEIHIKPILDKLDSNIKEAVLLAVHKGINFSSSNIEAETLNTNFSTELDSSHVNIKKMQSSDLNHEEILKTLKEDQNISTQLEDAKVEKFENTEALTLENEALAVKTSHFTLTPLELAIREVKDAYTKARKLYRISSKRRARIQEALNEFLGTHNFYNYTVQKKYNDPSAKRVIKSFDLAVEPVIMNQTEWLSIKVHGQSFMMHQIRKMIAMIALVIRCATPLRIIQESYGPERISIPKAPGLGLLLERPVFNTYNQRAITELHREAIDFDKYKAQMDEFKQKEIYERIFREEERDHQFSSFFNHLDHYQSSHFLWVTASGISAVKNGLVKEKPKVSLVYSEDEGDINEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9Q8</accession>
    <name>A0A0B1P9Q8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EV44_g5756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JNVN01001289">
        <property type="protein sequence ID" value="KHJ33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9Q8"/>
    <dbReference type="STRING" id="52586.A0A0B1P9Q8"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000440">
        <property type="entry name" value="CMGC/DYRK/PRP4 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="485"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KHJ33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="806" mass="92358" checksum="532A82F4D3ED2315" modified="2015-03-04" version="1">MASAESSDEGEIRDSSVEKANLSLFELDDTAVDSKDRKRSSSSSSTSFDYEYRSGDKPSRERSRSPWSYRHSLPTKRNREDKYNDRAQVDPRKFKIHYEDAPYEYQRRSRPQYSGPLNLSTLPYDDGDELYSNKRARTRSQSPLRAPRENRFSHSEYSRKTNRRSDSHYWKNNSHVNRGIRRRDQGQSVSYRGPSPLPTDNSSHEAKYRQGRIQNSDNDTKNQVDGNVLTPQLPAEEECLDEAALIEQRRKRREAIKAKYKASATSLEVQNLQLGDNPNKLSDDSNKKPLNTQQNNSSIKALRNTTNKNDIASPELCGPNTLMESIEPLSPSEFAVSKDEHTIFKEPISETSDEISGQSAADYDPTLHMREDRQRGDQRCNENVLIGERIEVTPKESTKSFKDSEMSAPDSIDKTNDDFDMFAEEDDDMFAEEPTVKQISKANDNIVMPTHIPQAKELDIGMLDNWDDIEGYYKVILGELLNGRYHVQANLGKGMFSGVVRAMDVTTKKLVAIKLIRNNETMRKAGLKEVEILQKLRDADPDDKKHIIRFERQFEHKGHLCMVFENLSINLREVLKKFGRDVGINLRAVRAYAQQMLLGLSLIRKCNILHADLKPDNILVSKNRNLLKICDLGSASDASDNEIAPYLVSRFYRAPEIIIGMPYDFAIDMWSVGCTLYELYTGKILFTGRTNNQMLRSIMDCRGKLTSKMLKRARFAHIHFDEMGNFRSVEQDKATGKDVIKTLFFTKPTRDLRTRLLSTTKGLSETETKEISLFTDFLDRCLALNPEKRITPTEALKHPFIMKTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1P9W1</accession>
    <name>A0A0B1P9W1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g0884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000377">
        <property type="protein sequence ID" value="KHJ35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1P9W1"/>
    <dbReference type="STRING" id="52586.A0A0B1P9W1"/>
    <dbReference type="HOGENOM" id="CLU_015780_1_0_1"/>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="369"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="529" mass="58356" checksum="4C9537952B46BE1A" modified="2015-03-04" version="1">MPPFSEPNNMHNFVTLVKRLEVATCRLEDLATSAIQQPNESGAESFTRLASLPVIPENALDSTTVPEKLPESVEGFDAFISGPVQGFVKISEDLGGSILEQANSLLKAFHGQRKFIYITTKAKKPEMNSPVFMELLKPLQESITAVSEIRDSNRGSPVFNLLSVVSESIGFLAWITVEPKPQKHIEEFYGSAQYWGNRVLIEFKDTDSRKVEWLQQYYQVFNNLSEYVKQTFPHGILWNPQGLTLEEVIKAFDQKTSPSSNKKTDFSQDFAPPPPPGPAPLPIVLDEASKNSPSEKSGGLGAVFSELNKGSDITKGLKKVNSDQMTHKNPSLRAGSSLLGRSDSDSSIRRSKSPVPGTKPKPENMRIKKSAVKKFEGNKWFVENFDDESEPIKIETSISQSILISRCKKTTIIVSGKANAISIDNSPNLSIIIDSLVSSIDIIKSPNFAMQVLGKIPTIMIDTVDGAQIYLSKESLGTEIFSSKSSGINLNILDPTKEDGDYEEVPLPAQIRTWIEDAKVKNEIVEHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAB9</accession>
    <name>A0A0B1PAB9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative calcipressin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g5297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001162">
        <property type="protein sequence ID" value="KHJ33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAB9"/>
    <dbReference type="STRING" id="52586.A0A0B1PAB9"/>
    <dbReference type="HOGENOM" id="CLU_050705_0_0_1"/>
    <dbReference type="OMA" id="RIVCSFH"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="255" mass="28292" checksum="912C317547045168" modified="2015-03-04" version="1">MSSKSSPPTFATSRTREGRSMTIDLSSLPPLNIPSPASNTLIITNIENSLVFRNENLLTVKALIHNLTPIHSWAPLKSFRRIIVSFFDINSAIQIRQLIESEAMLGERCKVYFGHPTPIEAKEAHLNLPDAGKLFFISPPPSPPHGWENRLEDAPNKQVVAEDLAKALKNIRDGNKSCFPDSPISDRGETGYRTRSTSCTTIYRPEEHGGSPNLPAINVEDTTGDNCEPIPMEHEKPIYAHTSRPPLELMDVCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAI6</accession>
    <name>A0A0B1PAI6_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EV44_g4411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="JNVN01001119">
        <property type="protein sequence ID" value="KHJ33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAI6"/>
    <dbReference type="STRING" id="52586.A0A0B1PAI6"/>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OMA" id="ARRCPIM"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902117">
        <property type="term" value="P:positive regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="112"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KHJ33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="535" mass="58729" checksum="1C49C9C39E2D0584" modified="2015-03-04" version="1">MKILLNPTLSRWHKKFVSNLSSLGTHYSKTRTAKLHTFSVKKAQALKVSSNCVDFYNESSSVKPLIEEFDYEGFYQAELEKKHADNSYRYFNNINRLATEFPRAHIPGKTDKVTVWCSNDYLGMSRNPQVLQAIHDTLNVYGAGAGGTRNISGHNQQAVALEETIAKLHAKEAALVFTSCYVANDATLSTLGSKLPDCVFFSDSLNHASMIQGIRHSGAKKLIFAHNNLIDLESKLSSVPHSVPKIIAFESVYSMCGSIAPIKEICDLAEKYNALTFLDEVHAVGMYGPHGAGVAEHLDFYSHAAQKPKGTVMDRVDIISGTLGKAYGSVGGYITGSSRFVDAIRSLAPGFIFTTTLPPAVMSGANKAINYQMQYQGDRCLQQLHTRAIKNELVARDIPVIPNPSHIIPILVGNAMLAKAASDLLLEKHNIYVQSINYPTVPVGQERLRITPTPNHNSALQEHLFDALDSVWKTLNIKYTSDWALDGGLIGVGEKTLIKSKPLWTNQQLGICEDVQKSSKNSVDSICYGLTANLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAL4</accession>
    <name>A0A0B1PAL4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phospholipase a2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000918">
        <property type="protein sequence ID" value="KHJ34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAL4"/>
    <dbReference type="STRING" id="52586.A0A0B1PAL4"/>
    <dbReference type="HOGENOM" id="CLU_016785_6_1_1"/>
    <dbReference type="OMA" id="YWHDMEF"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="139"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="331" mass="38371" checksum="EC93B5F687AB4AA3" modified="2015-03-04" version="1">MQQSEDPLTTLLRDYAEFNPPHIDIFDEPPSALEFMRYVSLNRPFVFRSGASDWEATRCWNVTTLKTILKDQFINVAVTPFGNADSPVWNENEDELLFVKPWIVQQQFSKFIDFIIEQENKKNDDNYELKEVRYCQTQNDNLRDEYVSLFPHVASDIPWARIALQKTPDAINLWLGNSLSVTALHKDNYENIYVQIIGSKHFVLFPPIAYAGISEQTLAPASYIKTPDNKWKIQKENGAKIPFPTWNENKEPDKHSLHKKYSDLIVPIRVTLGKGDILYLPALWYHKVSQSCSEEGICCAVNYWYDMQFNGPLYSLFNFVQNTIISSTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PAZ5</accession>
    <name>A0A0B1PAZ5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative raffinose synthase sip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EV44_g2456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000404">
        <property type="protein sequence ID" value="KHJ35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PAZ5"/>
    <dbReference type="STRING" id="52586.A0A0B1PAZ5"/>
    <dbReference type="HOGENOM" id="CLU_006630_0_0_1"/>
    <dbReference type="OMA" id="AGWSNEV"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KHJ35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="867" mass="97926" checksum="FD8E9425F537A04B" modified="2015-03-04" version="1">MKTIISSYPPLGKVSVIDSTSIVFFVLLEVDNTSQGLEWQVSLSHSDLETEDWIEEPLTFVQNISDQFIAFSGIKSKLELRKLYFTATFSVNHTFKFTIKFRKNIENYWKSSRDLNTSDGIIVIKPKSQENVDLYGLNHYIHGLDPLFQTKKCSEKNHNNFLWYIEAPVEAADGEISRIKDIEIGTPWGKNNVLRWMAIVRNGYPWLAPRQGMSQFELDSEAIICSFLSKLGKHLVLLAISGIDNVTTVFTSNDKGNVVLRVRNDGAKGSLCRVIIGIGDDFESTNAAVLGYARDMATNLEEEILGQEVKQRKSFTDKNITKLSHEDWHDGLTFCTWNSLGQRLTAEKLVSAAKYLAQNNINVTNFIIDDNWQSLDYRGDNQFQHGWIEFEADRNNFPLGLKHTVNCIREQQPSIKNIAVWHAILGYWGGLAPDGKLAKLYSTSKIVRTDTEKQNLPIDGKITVIAKEDVMKFYNEFYRFLSSCGVNAVKTDVQSMLDTFVSAEDRRDLINSYLDAWILNAFNHFGLNVISCMSQTPHSLFYSHMPLNKPRFLIRNSDDFYPEIPTSHPWHIFSNAHNALFTQHLNCLPDWDMFQTVHNYSGFHAAARCVSGGPICITDVPGEHDLKLIDQMTSLGPDGNTIILRPSMIGRSLYQYTNYNDCKLLQIGTCHEGTGIIGCFNISEEYCSELIPLANFPAVKNDMQYIVRVHSTGIISKPLQLSDSDTLICISLETRDFDILSAFPLKRIINENKDNEMLVANLGLLGKITGAAAVIKSRTLHLENEIVLIETRLKALGVLGIYFSSLRKSFNKESFSASILEKTIPADTIKNSDVDAHVIEIDIGMAWQKLGLSYLDRNEIDVKIQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PB56</accession>
    <name>A0A0B1PB56_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative catechol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000377">
        <property type="protein sequence ID" value="KHJ35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PB56"/>
    <dbReference type="STRING" id="52586.A0A0B1PB56"/>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OMA" id="AMGPKTT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="286" mass="31934" checksum="A3827A01321B072A" modified="2015-03-04" version="1">MTSNSKRESSHTQNVIDAIGTGVSLRIRQVMSSLIKHLHDFARENEITFDEMMAAIEFINSAGKMSDEKRNETLLLCDILGLESLLEEIALSKENKDNSSATVGTVLGPFYRHDAPVRENESSISQPADEKDTIYVHGIVSDLNTKKPLAGAWVDVWQANGIGLYEQQDQHQVDYNLRGKFKTDKNGHYGFYSVQPGPYPIPSDGPAGDLLTLLGRPIYRPAHIHIIARCEGYKSLITQIYNRKDPYLKNDAVFAVKDSLIVDFEPMEGNSKAKLEVNFPIILVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBB4</accession>
    <name>A0A0B1PBB4_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000172">
        <property type="protein sequence ID" value="KHJ35987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBB4"/>
    <dbReference type="STRING" id="52586.A0A0B1PBB4"/>
    <dbReference type="HOGENOM" id="CLU_018153_0_2_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="379" mass="42279" checksum="A99B670EB078867B" modified="2015-03-04" version="1">MCSPLEFSQQTKGVKINAISNMNLPKKPTVAATHRINATLKTANALPIVPKTTPMLWTTVVRNGQKKTRLNEPNNKKQLKSTDDMRLFVRLSNEHEWRKLSPAGIREVVFKKLSISPTSIGLIKPVRTGFALSPRNNEAREALLKLSLRLSSFEAKLEPATSWLPVIIPTVPRYIRTEKGQVEVTKELLSDEIERVTSMRPNSIKLYGHGHLEAPHRTWLALFTKAPRPGFRVFDEFGIMSLIKKQPLSDFCKRCNGYHSPKNCSRAPSCGNCGSTMHSEDLCMAPTKCKNCGGPHRSDSRKCLARPTRNGAPAKEQLKIIRQAGDREFQAVLRAKAAEERASVLEGNFDEEPSQPEVVDMENTQASSVEDTAGDAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBK7</accession>
    <name>A0A0B1PBK7_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative benzoate 4-monooxygenase cytochrome p450 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EV44_g0896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001082">
        <property type="protein sequence ID" value="KHJ34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBK7"/>
    <dbReference type="STRING" id="52586.A0A0B1PBK7"/>
    <dbReference type="HOGENOM" id="CLU_022341_0_0_1"/>
    <dbReference type="OMA" id="ALRCCIN"/>
    <dbReference type="OrthoDB" id="3759773at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KHJ34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="613" mass="71524" checksum="07B88A700287E794" modified="2015-03-04" version="1">MKLNKEPSEEEFSLDILYQKLRDLELLEEQVLASIDCFFGRTFFNGMEIYTDESNCQKIRHKSFSDTPFFEDVRDKVIFFKNAIQNINQFRDILRNHINICSRPYLRQLHIFDLPDEILMHICEYVQGREEYYIRYLPEINVGVQEVKNMRLTCRRFCNVSSHLLISCVNLELDTTSLFYLKEISRHPTISLGVEVIRINLLYYDSVLEEDIDNFGDYHAQRLLETTEFIEDMANNDTEFFLNTPKDIVESSIQKARSIGNAWLDFVAEFSNEISNEDLGYRKLLLRAYRKYKRLYARQERLYANDTFPRTIAAAMSRMPNAKRIDIFNSDFTARPKRCRRPDFMTMMSSDESLINSTLYPITWEKGRRFQLGDPPFALLFQIPKAIKEAGIFLTALDIKVPPDDFYKLSSDEGNLQNIIHSTQGLKSFSFDPKVPYCSDLWAADHAHEVEAFGKFLSAHLSSPTLRDIQLSCDFLRADESRPWFSLGFVLTQNSWPKLESISLTGLAFHFSDIEKFISQFDHPIIIWFKRVHLMSGTWESVLDVLHGKVGAYPTLEDLSGAEFDNFSESEKALIMGKQDNSWDMNQAELHLLATFNIPNPFRRRDTEVIIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PBU9</accession>
    <name>A0A0B1PBU9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g6404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01001025">
        <property type="protein sequence ID" value="KHJ34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PBU9"/>
    <dbReference type="STRING" id="52586.A0A0B1PBU9"/>
    <dbReference type="HOGENOM" id="CLU_038732_1_0_1"/>
    <dbReference type="OMA" id="IDDLPSC"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="330" mass="35715" checksum="9DF0EA842960AEC7" modified="2015-03-04" version="1">MPFQTKLTQALGIKIPIVQGGMQWVGYAELAAAVSNAGALGILTALTQPTPEDLRKEIRRCKAMTSNPFGVNITLLPALVPPPYAEYAKVIVEEGIRIVETAGNSPGRIINQLKEAGTIILHKCTTIRHALSAIKLGVDFLSIDGFECAGHVGESDITNFILLSKARQSLSVPFIASGGFADGQGLAAALSLGAEGINMGTRFMCTVEAPIHENIKREIVKADENSTQLVMRRWKNTTRLYKNKVTLQAIKIEKDSPTGKFEEIAPLVSGKRGREVYTTGDPEHGVWTAGQVLGLIHDIPTCDELVKRIEIEAEKTLRKANALIIPTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCB8</accession>
    <name>A0A0B1PCB8_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">EV44_g4772</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="JNVN01000082">
        <property type="protein sequence ID" value="KHJ36302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCB8"/>
    <dbReference type="STRING" id="52586.A0A0B1PCB8"/>
    <dbReference type="HOGENOM" id="CLU_004391_0_0_1"/>
    <dbReference type="OMA" id="CHMTALF"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="1115"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="20">
        <location>
            <begin position="1241"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="377"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="731"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KHJ36302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="1257" mass="141716" checksum="39A96DD39F1B6960" modified="2015-03-04" version="1">MSRASSTSFAQFFPSAPRVAKNKAKERERKSQALEISRSLIDMKVSLTKPRVDIASPVGEIISHTAESSVIHNEDNGSVQGDTLNEVGSASSHASSIFSGLSQPSNLSTLSCSRNVLTPSTNTELSSPNGLMSPNYKRAISTGNDSSTINSKENHKNSKSSQNQNIEAGRNSIQKRVHARDPTKNIKGYICTYDPLRDKKLSSTEKKKLKPIYKEFGSEDDAPQTDPRLAKRGGKLDYINVDYHNPKSRLRHAPYLLKPYIYDAKTSLGPSPPTQIVVTGFDPLHSFANVSAIFSSFGEIAESSNKLHPETGSCLGFATFRYRDSKNLRGGRFISAIEAAKIAVRKGSAMRIGQQNVKVEFDPEGNRSRRMMQNILNKQKPTKSIQKAPVAPTQKSPEPTKAQTTGPPPTAPKGPSSTRPVFRPLPQLNAATVVPIHLRTRWIVENNPILPQIRNQPYLFVPGESVPIMTSTPNHMLKRMKHFHVEELRIDKSGYFIFFPNNGLGRADCEKCWKALNDTLMFSYTMKIQAFLYGNCGPRAVIRQVSGTSHPGSQSNLALQLKSQELNDLSNRLKEEEADFEEEKKERAKNFDPAREAIEVIRRDLKEQLLSNIKSNIATPCLHNFLDPSNHMAKRRKLNIPDPTDMVFKFENEENFDEETTSYTEISNNRIESRRGLLGVSSLPRIRKTKDAGKKINVGFQDPFARARRRNQKKPLYRSLVSLILEDSDDELESRSRVQDTEEPESLPQSRMSSDDEASDEEIDDLSLNKNLLVNNKDEEVSTIDVNSVIDEPISLLNKRKIENEIQTSVKRLKKTDEELFGVDPERIEQEFPLFAEHSDEDTVMQDTESQAQVDEVSIPAGNKKKYTAPKKRKMTKKQSLLEKHLVETIEEETVISETASTLLDDTEEFIMESRPVEATVEWGKSSSEPRSTVVDDFANILDIDGLQSLIRDDEDCMMLKECLNNSDSRSKNWWKTWCWKQKEIKAINMDGYQGPITKEISLDGYYVPNKTGCARTEGTHKILNAEKSLYLPHRIKVQKAREAREEAQALKNGRDLAAEAAEALKVKKDKAAKSNTRAARISNRRYVADLNDQKKTLGGEGDVFSFNQLKKRKKPVKFARSAIHNWGLYAMENIPTNDMIIEYVGERVRQQVADGREMRYLISGIGSSYLFRIDENTVIDATKKGGIARFINHSCVPNCTAKIITVEKTKRIVIYALRDIAQNEELTYDYKFEREIDSTDRIPCLCGTEACKGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCJ9</accession>
    <name>A0A0B1PCJ9_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative abc transporter atp-binding protein arb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000033">
        <property type="protein sequence ID" value="KHJ36407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCJ9"/>
    <dbReference type="STRING" id="52586.A0A0B1PCJ9"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="95"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="406"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KHJ36407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="627" mass="70041" checksum="E9FB3660AC7F0438" modified="2015-03-04" version="1">MVSASKAAREAKRAAEGKTTKKPLSSRSKTNSKNASGNKTPLLDANGNPLPDDQQTENSLKNDEINRLASQMDKQGLSDRVTTGVLSSLKQSRDVKITSVSLVFHGRVLISDTILELTYGRRYGLLGENGCGKSTLLKAIDKREYPIPEHVDIYLLNEGAPPSELGALEWVVKEAENEMERLDKQAEQILEDDGPESPLLMDLYERMENMDPSTFSTRASLILTGLGFNKKTISKKTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWDRSLVLVSHSMDFLNGVCTNMIDMRQKQLTYYGGNYDTYQKTRSELEVNQMKAYHKQQDEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGFIQKVEPDRIFTFRFADVEKLPPPVLSFDDVTFSYSGDPKDDLYRHLDLGVDMDSRTALVGPNGVGKSTLLRLMTGKLSPTSGTISRHTHLKMGVYSQHSSEQLDLTKSALDFVRDKYSEKSQDYQYWRQQLGKYGLSGDAQTALMGTLSEGQKSRIVFALLAIDGPNMLLLDEPTNGLDIPTIDSLADAINAFTGGVVVVSHDFRLLDKIAKDIMVCENQTIRKWSGSIGDYKNHLRKKMKEAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCW0</accession>
    <name>A0A0B1PCW0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mutator-like element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000490">
        <property type="protein sequence ID" value="KHJ35180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCW0"/>
    <dbReference type="STRING" id="52586.A0A0B1PCW0"/>
    <dbReference type="HOGENOM" id="CLU_019832_0_0_1"/>
    <dbReference type="OMA" id="KVFLICD"/>
    <dbReference type="OrthoDB" id="2422440at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="499" mass="54981" checksum="CA43A9D689ECE6D4" modified="2015-03-04" version="1">MSMTPQDSARNAFSAGSAQHVFRLHHVGRPQSLQHRNFGRPGMGVLRPQTQSSSQQTPYSGPYTSNPDSQSNSNNKNSAEQQIAQGILSNASPMTTISPGSNTAQRRSSSLSTAIHIPGSSTPRNQSISLSHAVNPSSVMGHSQSPSQPQQDSSPALHQSRQQSVQQTLISPATNDLGSTTQERSIDSPQDMSLIDPQLGINHQLSPNNSSVTQVSSAEVPTVVQGEMLSPPPLGSFPTFEALFAFAQAHALAHGYAFVIGRSKRDNRGLKKVFLICDRGGTNKEKLHGEQRQRKTKSRKCGCEFGVFGLENKHAWVLRGRMDGEHLIHNHPPSESPTEHPGARKLDPKAIAAVKALEENGVSVKETLEILHRENPSVRYLPRDIYNARAAIKRDPTRVEATAMEELPTFYKKPPMTFEEKLRAELRTEVANAQAEIEKTKEAWRKEVEELKTQLDEKQKMIEKFELFIDICNQRVMVQRELLDDHPPNGSVGGNVGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PCY6</accession>
    <name>A0A0B1PCY6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative eka-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000482">
        <property type="protein sequence ID" value="KHJ35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PCY6"/>
    <dbReference type="HOGENOM" id="CLU_921950_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="302" mass="34277" checksum="C0B905AE5D1991C8" modified="2015-03-04" version="1">MHFDEQFEDVEDMLKVAEALEQMRQGHNQYFEDFQHDFKSQYSLCDVNTWGPTRKIALVHTAINGQLRETLVGIDLSVTRKECSNNEGLALQNAKLVPASDLITYRIATVPVALRTPNGTLIFEETNLAAKITRVTNVIPRMVRQHGKTRVGASYRSWLAHFARDQAPRPGFRLFDESGIAVIFKPRQPIQQCKRCFGFHVTRSCSRAPACENCSSTIHLVTDCKAPTKCRNCGGPHRSDSRNCLARPSRSGPVTKDQLKTIRQMSQREYHAEARLGLKLPLYVQKQQLSMEKRHLSAQKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD02</accession>
    <name>A0A0B1PD02_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">EV44_g5728</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="JNVN01000129">
        <property type="protein sequence ID" value="KHJ36138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD02"/>
    <dbReference type="STRING" id="52586.A0A0B1PD02"/>
    <dbReference type="HOGENOM" id="CLU_011476_0_0_1"/>
    <dbReference type="OMA" id="QYPDCLK"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KHJ36138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="722" mass="80279" checksum="E77602A9C513FED8" modified="2015-03-04" version="1">MSRRCSLEHSRKPNFQGKFPLKPRMLVDFLQAIHPDEAGISHKLYREDRIPPQLHRNHNHSESNQDETHLPSLLKIKKPIPLHSSQQGNYSLASVDRYASEGHRDQALNPSDCNFQLALGAENNYRECVAAQVMENLNTLTQGRQPEKDQDVLRDTSNYVYGTDLPVNSKKSSHSSSHNFLETHSDQFFTSKTPLAKAAMTTGNLTPPSRPANSHSQLSLNYDAYTDIPYRYSRNIDPNLCDFDPRSIEDDGDDGLGYKQHVHRSSVLSFGNSERNSLHTSAISGVSKGSLFGSLGTALGRKPITSASDSQNYDRNNYIKNIDNAANGADGADSTQNTHEKSESEKSEWLSKQSNGRSKLRLLVFLIVTVVALGGITGAIVNTILHKKSLDSADKSAADDRQNNGDLDKNSGEIKKLMNNPHLHKVFPAIDYTPSRSQYPDCLHNPPSQNDVTRDLAVLSQLSNTIRLYGTDCNQTEMLIHSIDQLDLKKKVKIWMGVWLNQNETTNNRQISQMYRILDVYGTDPFVGIIVGNEVLFRQDMSPTELGNRLTSIKSNLSSKGISLPVASSDLGDDWTAQLASKTDILMANIHPFFAGVSADVAASWTWNFWQQHNVILQPDLSKNIISETGWPSSGGISCGGADTCTEGSVASVDAMNTFMNNWVCQALQNGTNYFWFEAFDEPWKTHLNEPGKEWEDKWGLLDAQRNLKPGVIIPSCDGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD43</accession>
    <name>A0A0B1PD43_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mediated genome instability protein rmi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g1945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000805">
        <property type="protein sequence ID" value="KHJ34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD43"/>
    <dbReference type="STRING" id="52586.A0A0B1PD43"/>
    <dbReference type="HOGENOM" id="CLU_093893_0_0_1"/>
    <dbReference type="OMA" id="MTSPDQI"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="1">
        <location>
            <begin position="93"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="282" mass="31858" checksum="85810F72E1DAB968" modified="2015-03-04" version="1">MATLPIQNQITTLMASQGLPILHSSFLNSILTRSSSIRQQPISVIVATVKHRLLCSDINIQNNNNNNNDISNNNNNNINMNNNNILSSTSSYLPTTIINNKQIETSFLNYDIFVQVLDIEDIGQSKWDQLEFLEAEKRGEKMKGREIIRTVVPVSSFDEEENEYSQDHNISDSTMVVKSHKFLSQNNSSEKQGKGPFKLILQDWKGTKTWAIELKRVDKIGAPPVMNIGCKLWLRKGCKVARGILLMEPTTVSVLGGKIDILDTAWKTEREKWLKEVLNGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PD55</accession>
    <name>A0A0B1PD55_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative complex i intermediate-associated protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EV44_g1022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000798">
        <property type="protein sequence ID" value="KHJ34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PD55"/>
    <dbReference type="STRING" id="52586.A0A0B1PD55"/>
    <dbReference type="HOGENOM" id="CLU_059028_1_2_1"/>
    <dbReference type="OMA" id="WIKAVAQ"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="44"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KHJ34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="271" mass="31143" checksum="28204D89590FAC4A" modified="2015-03-04" version="1">MRLTLSLAAKGFWGRSFDEFKRWTTMVLNSEGMRVPTKPYILASFENPTFINDCKIMSDQDIGGFSTSSLEWIPPCKSSNPTLADNLHGHARFHGNISIQLPLNRPEIQRTGFAAWRTKDRGYTIFGKSLWDIDPYTFLALRIKSDGRKYFVNLQTESIVQTDIHQHRLYAKRPGEWETVLIPWSEFVRTNHGVVVEPQREMLRQSLRTIGIGLTDRVPGKFMLCIEKIWATNNLDAECLGQVSQKDNLHLKTKNGNNITWVEVDDNKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDA7</accession>
    <name>A0A0B1PDA7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g5250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JNVN01000444">
        <property type="protein sequence ID" value="KHJ35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDA7"/>
    <dbReference type="STRING" id="52586.A0A0B1PDA7"/>
    <dbReference type="HOGENOM" id="CLU_028491_3_0_1"/>
    <dbReference type="OMA" id="FTEWITL"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="16">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="15">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="337" mass="38237" checksum="69185CD7EA33C3CB" modified="2015-03-04" version="1">MEELVEAFKKARAGVLEYAIKSSRLSISKSPSKRKFEDIGQDGEIISPTKRTRYSKRLEKITKNELISDPEGDNGYKISEACLVQCPICNVQMPNSQVNAHLDRNCKEEVSTSIRPSRTIKNSIDPFWAGIEKPVKRPERLPLLNLSMFKDSQLKKKLGEYGLSQGGSRLVMQRRFTEWITLWNANCDAKIPRPVRELRGELDRWERIQDGKGSTSSSSSISNPSIKIKEKNFDGKAWSNSHNDMFKELTLKAREKFAKSSSRPPETILEPHVDSKAECEENNIALPNSSQYMPSLQECDELNSEISGLISSQKQKYFFDEPPGKLNECNAIISEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDL3</accession>
    <name>A0A0B1PDL3_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative plasma membrane g protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EV44_g5625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000389">
        <property type="protein sequence ID" value="KHJ35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDL3"/>
    <dbReference type="STRING" id="52586.A0A0B1PDL3"/>
    <dbReference type="HOGENOM" id="CLU_017709_1_1_1"/>
    <dbReference type="OMA" id="FWFFRMR"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="430"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KHJ35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="599" mass="68227" checksum="43DFEBF460210C83" modified="2015-03-04" version="1">MASSSLGPITTEVPTTAFERTLEIYLNDASTTTSTLVKSSTDEYRILIFLSFFFASISVISSALAFYWFIKMRRSFRHDLIMLLIQSDMFKALWFMSYPLVFLVSGPVRSESAFCQISGFFLTVGIEQSDIAVLIIAVHSALHIFKNKPFGKEEGLYPYRHTAYTIWCLFPLGMASLAFLGGPHAYVVSEAHCYLPSRPLWYKQTLSWVPRYFIFIIILGTYCSIYYYVRNKFHSFTKDDMEIPRSYLPYSRSRAPTPPLCSNGLTLESSITSRDENEETSSITKNFTQKGSKSHAAHFMMTASFARISDSNIPPVRSPIRSSVGRLSIRNSISIYPLPNNLRSALLSPHHTFAISETSADPPEATSPWFEMCIRRYSTPASNQSIPSPNTENVNITSMIPVTSKIPTTVSVAQIQQSLSHITGRAEMMARRDQIQRQLRFLFIYPLIYMGMWLMPFVSNVIQFDDKYALNPPFPLSCITTVSIGIQAFVDCWLFVSREKPWRHIPGNNGSFWASLKFWTDWSGLAVVNGYNSGPGRTRDEMVREARAAYQRRDDELASRRNQLDESGGKYEYPNPQRCWWDAERSGDFDIISSVEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDM0</accession>
    <name>A0A0B1PDM0_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g4996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000383">
        <property type="protein sequence ID" value="KHJ35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDM0"/>
    <dbReference type="HOGENOM" id="CLU_037771_0_0_1"/>
    <dbReference type="OMA" id="MFATSHH"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36966" checksum="19568E9FC06EC7AC" modified="2015-03-04" version="1">MFATSHHSTERASSVTLPPSSSGYPTPPASASPSQSSFHRKNQSPPTQPKKNKLNEFGENGAARRRCSSLCERFPGDMSHRPLDVLRQETKAANRAPHLKKKHIPGADTIDSLDRSAFGLSYHHAGPYDATLLARNRTRRHAPVEALKSSNNEAIKATPKEFIKASLERHLPLQGTAVIPPGMAGIDGDIMQYEEGADLMREPDAPGGAYKRWPDMKYLPDDLKGKGEPSFSIEKAIKKDKQRHTVSGNINNYEMYPLKSPKSPSYYSHGNNGRTRLGLEPNEFKPTWNSSLYPDYYNSRRRGLSTGQRVGEGLKRRLENLAWIKKTTGTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDM1</accession>
    <name>A0A0B1PDM1_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g4959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000072">
        <property type="protein sequence ID" value="KHJ36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDM1"/>
    <dbReference type="STRING" id="52586.A0A0B1PDM1"/>
    <dbReference type="HOGENOM" id="CLU_003271_0_0_1"/>
    <dbReference type="OMA" id="ATHVYYT"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="125743" checksum="3D74616ACC9B60E1" modified="2015-03-04" version="1">MHAIRQKCRPKHQVLILNCYPRTVKGAVDVKPNSSELSYLLYYATTRRSKIQKVGAFLEKKTASDVWRARIGNVQVTLQIVTSLIEKAPRDLPLYASHVLKLLNIILIAHDITMIESSLSTFESFCQNHDEASLSANQEYLYQYEDIVSKYASLASVYPPITNSTPSTPIALRWKNVGLQAIKSVFSSEALASIVVRLLNLIVPTLLDNLWSESSDYINMLEQKTEVEEKFRSKSFSRRRASVATIHTVETSPSSKAALSGTTADADKVAEEDNTVLSLQCLKLIFAVNNKAQIIGATLATLKYIESCYLSQKEESPPTESRAIQIFQMISHWAPVQDRYTLLVTTLDILLNSSIDGEEFQKQLLYATMIDSLLKSDVNLIGLSVLNVLVGLVQLLLRVLQSSRPPSQETNIISAINTMNDGQWPLKNSTENHFESHSKSKLREMLLEKLQDCIGNLATHIYYADQISDMVSALICRIKPNLSSNMQALASATEASALVDTISNPTGDLEESNSDGVFLLTNAKVSALKAIKSILISASLQKRLSVIGNLARNYVSARVWEGTHWLLRDSDNDVRKAYVAALLTWMKYEVSEANTRVPDSKSIITPRTKNLDTTASSNARSISNTWPKEKSTTKLQPQIAFLDFLHLTIYENALKYSENEEDIILLHILLYDLVDNLGMNAVRFGLPMIFRLQEDISEKLTPLARTHISSLCYGYFWTLSEKFRLKSTPVDIEIHREILRRQKIQLWINKIRCPPPCLEQIRTPDQQDQSQSFSIKNFQPDSLKPFTRRSQMVELILSSYVEGLMAQASSFSASPSRTYFPPLMDLSKNTVEFEIPENIKELMSSEWSPENVAIQQSIKPQSLSGSKTGASTLRHRNFLAVSAHSRSYSPPSYNQSPLACKNGSRSSLNNGLGDSLGALKKTRRASELSTSICRESRRNSITRVEYLKRVLSGQERKVSRGRIVGNMTPSDASSESMVSYAYTTSEISFNPSQSNLSQLEFSASDRESNKLVRSKSHDEEPRCNAPLSSNPVLIDDRFDCLSNSKEVDAVPPIPSIPVLYKDENTAESDLALEDNKSIGVNKSSRPQTRLFSNEPLETLEIFLKEIDIGSETESEYVKRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PDT5</accession>
    <name>A0A0B1PDT5_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EV44_g5850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000523">
        <property type="protein sequence ID" value="KHJ35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PDT5"/>
    <dbReference type="STRING" id="52586.A0A0B1PDT5"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="NVMMKNM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140157">
        <property type="term" value="P:ammonium import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KHJ35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="485" mass="52222" checksum="A9DCC1D295A926D9" modified="2015-03-04" version="1">MSNNEYFTHNATSNLAVLISDDALAAANDVNVLFDSGDIAWVMTSTALVLLMIPGVGFFYSGLARRKSALSLILLSVMASAVVSIQWFLWGYTLVFSRSGGKFIGNFSNFGFLHVLAEPSITSPKIPDLLFAVYQGMFSAITVALTVGAVAERGRMLPAIIFMITWTTVIYDPIAYWTWNPSGWMFQMGALDFAGGTPVHISAGCAALAYSLMLGKRRGHGTGELNYRPHNVMHIVTGTIFLWVGWFGFNAGSANAANLRAVMATVVTNLSACVGGVTWCLLDYRHERKWSTVGFCSGVVAGLVAITPGSGYVPAWSAIVFGAVGAAGANYATKLKFIFDVDDALDIFAEHAIGGLIGNILTGLFATEYIPHLDGVTTVRGGWLSHNWVQLGYQLADSLAGGLYSFCGTCIILFLMNLIPGLSLRVSEKDEISGLDEAEIGEFVYDYVELSHEILKGLTLNGLNVHSNTHGLDSQVQADQEEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PE41</accession>
    <name>A0A0B1PE41_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EV44_g1369</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000631">
        <property type="protein sequence ID" value="KHJ34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PE41"/>
    <dbReference type="STRING" id="52586.A0A0B1PE41"/>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KHJ34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="96" mass="10310" checksum="B7F1665E615E9A0F" modified="2015-03-04" version="1">MFGLGRPQPSSAEKIAAAEQEMDMVTDMFNKLQKICMKKCVPQLYREGELNKGESVCIDRCSAKFFDVQLKVSELLQSEAAAKGASAGGGGMGFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PED6</accession>
    <name>A0A0B1PED6_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g1189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000580">
        <property type="protein sequence ID" value="KHJ34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PED6"/>
    <dbReference type="STRING" id="52586.A0A0B1PED6"/>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="OMA" id="GPIRTNS"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="57"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="422" mass="46552" checksum="E9C1CA4E68467DD1" modified="2015-03-04" version="1">MRNLARIIANTIMTTEAKRVLIPKNGVDYRGKIVLAPMVRSGELPSRILALHYGADLVWGPETVDRSLIGTTRRVNHHLQTVDFTRLPSNGSKIPRVDQKESIIFRLHPEKESKRLIFQIGTSDPVRAVEAARIVARDVAGIDVNAGCPKPFSTSGGMGAALLQTPEKLCAILRALVKDITAEFEIGISVKIRLLDTVESTLSLVNDLCETGITGLTVHCRTTPMRPRERAIRDQLKMITALCREKGVACIMNGDIQNRQEAEKLIAEYGADGAMIASAAEANSSCFRSDLEGGLAPWNEVVRQYLEICLQFENRFGNTKYLLNHLIPGKQSVYREMTASKCYQQVCSYLGLTDFEVRSKQVDESLGINMEERVDGKRQRKQNKSAIAAGGNQGIKQSLEAKGKRNLSERGAPNPTAPVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PED7</accession>
    <name>A0A0B1PED7_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EV44_g6160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000296">
        <property type="protein sequence ID" value="KHJ35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PED7"/>
    <dbReference type="STRING" id="52586.A0A0B1PED7"/>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="OMA" id="AVMITCN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="116"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="312"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KHJ35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="480" mass="51416" checksum="6E53C99DC6AABA56" modified="2015-03-04" version="1">MVVGIHFRQTLRKAATNPRHIENNSNQPETMLSGENIGLLTGRTSNARKSAWRQIYDVLGSKHYSAGKDSDSKIVRAIAPTIQITKITLYSNYVNFLLIFVPLGIIGGYLSWNPSIVFFLNFLAVMPLAAVLSFATEEISMKVGETLGGLLNATFGNAVEMIISIVALKNGELRIVQSSMLGSILSNMLLVLGCCFLAGGIHNRRTGTAAGIEQSFNSTVASTMSSLMTVAAATLIIPATLYAALSTSSENTNNGIQFLSHGTAIILLTLYILYLTFQLSTHSSLFDAESQEQAHNFEAESDDTHMGAWPAAAVLIIVTVAVAICAEYLVDSIDSIVATAHISKTFIGLILLPIVGNAAEHATAIVVAVKDKMDLAMGVAIGSSLQIALLVTPSLVLLGWIIGQPLTLRFETFETMVFFLSVLVVTYVIQDGKSNYLEGAMLLGLYLIIALAFLVYPDDAGTTLPMTSSISKIANNLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PEQ0</accession>
    <name>A0A0B1PEQ0_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ccch zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EV44_g5982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">c</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000419">
        <property type="protein sequence ID" value="KHJ35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PEQ0"/>
    <dbReference type="STRING" id="52586.A0A0B1PEQ0"/>
    <dbReference type="HOGENOM" id="CLU_070360_0_0_1"/>
    <dbReference type="OMA" id="EGLWHLD"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KHJ35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="321" mass="37048" checksum="F7B513738579E19A" modified="2015-03-04" version="1">MFCAENFEDIFDLDQNDFYNDNIIISICDNRKTLQMLFIDRIMKILGIKKPHRLYPPKSSDGLKNLHNAVIETNGTDHYKLSVFFYVLLEFDRVMSTCQSSEVFVQKSFLPKKYQTLIKGLWHMDHQEFEVALQYLAHPSLIPSFPDEIIEVLCKASKDDPTLPIAYYHSVQPALSNQQTVNYLLKQLARKSVTEAFFFTRTRNECFQQATFELLIHLVLDQSPGDVGEKCLELINLPFTSQEEVWFEEYLLLKDGRTLKGAKDVLMMRSIGTCKFNEFLSLNNPNIENINGVNWNLISNAVFSGLGPRVSTEKRNHSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PF70</accession>
    <name>A0A0B1PF70_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative impact protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EV44_g5847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">c</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000352">
        <property type="protein sequence ID" value="KHJ35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PF70"/>
    <dbReference type="STRING" id="52586.A0A0B1PF70"/>
    <dbReference type="HOGENOM" id="CLU_031573_0_0_1"/>
    <dbReference type="OMA" id="ELDKRAW"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF4">
        <property type="entry name" value="IMPACT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="252"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KHJ35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="496" mass="55675" checksum="9E713D37A17259EC" modified="2015-03-04" version="1">MMATEKDVQDLLRLLTTGRNKLPMLDAINLIKTLKSTNLHSISAIATTNFASLKNVIPDEKIAKALLTICKKHIKTEDKVTPKRIAKFSSSAAKRHKSMYEIIDQPQTPAELEASLSLPKPSVDEEAISKSVIYTDRTSLLLAFAFQLIKYTMPSQPLSSRLSLGQAVVSFNTDCKVAGSRIKKPNSSQQISLGPKIRIMTSNISVLKRSGYDWKSDETNNESMIGHDKLYCKENNDPSNNVWKISKSITMKKSTFIARSKHISSSSDAKFSLQQLFLENPSLREASHNVSAWRIHIGNSVNEDSNDDGEENGGQYLLDILRNKNINGVLLVVTRWYGGVLLGPDRWRLMSEVSCDCLSQHLQIIGSIGQDALWGIDYQDETKISMIDRAMPIHKPERARDCLLTSFASTTKFGNFKKKKSSADLNYEKEDNLSLLLGALDLLFASWVNTLTFDELDRRAWAWYIRMRPSNEGGLIGWSENGEVKLSDILNLRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFD5</accession>
    <name>A0A0B1PFD5_UNCNE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EV44_g6494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">c</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000164">
        <property type="protein sequence ID" value="KHJ36025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFD5"/>
    <dbReference type="STRING" id="52586.A0A0B1PFD5"/>
    <dbReference type="HOGENOM" id="CLU_022339_0_0_1"/>
    <dbReference type="OMA" id="IWVPVWG"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KHJ36025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030854"/>
        </source>
    </evidence>
    <sequence length="580" mass="66473" checksum="096C3EDE09E807D0" modified="2015-03-04" version="1">MLIECEYSATEKPHNSFRINKLIPSSIPPATGPSTPANDQPSLHFKSNGSEDNVVPPERPQSTPFPVHEAGDRLIHCTYYNYDNDDMKDVSAQLVTLPIKATESAPLCNLPSEIHEYILDYLLGVRESSALKVTSSGKSKFVRGWGSALRHSRRREVSQLALVSRTWRDIIQERTYRHLKIRGTRNYINDAIDWFEHHPHLKSYIRHIDIWFPVFQQKNITIDPALRVPSNTSERSLFNLPITTEFTLPITYQSPLDNCTLEQVFRFIQDTFDKVCILTLEGGERKKPPMVRYFQQSQTQNQLPVLPSVRTLVCKGQWNIIRSNTDFENLAKALPNLNEWHAFYSKPKSKSYLSMATILPKLPRYLTHLNICLEADYRREAFIPEYAKKVRRKTHFCIEMARAIPTLEYLAYTGRLCHEFFNTAALLSDSRESRLRTVDIVVKNVCRPSVPELGWGDGSSITDMKFITAFENLVVAAICSLGRLAMIELLRIRFIDLESQIPGLNPYFQYNKDKCTGIWSDSIVESLQRNRPAASFVEKPEILDDFKIGQLFASTPFSKSRPLCIKISQYACLVNGINMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-03-04" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0B1PFF4</accession>
    <name>A0A0B1PFF4_UNCNE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EV44_g1250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Uncinula necator</name>
        <name type="common">Grape powdery mildew</name>
        <dbReference type="NCBI Taxonomy" id="52586"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Erysiphales</taxon>
            <taxon>Erysiphaceae</taxon>
            <taxon>Erysiphe</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="BMC Genomics" volume="15" first="1081" last="1081">
            <title>Adaptive genomic structural variation in the grape powdery mildew pathogen, Erysiphe necator.</title>
            <authorList>
                <person name="Jones L."/>
                <person name="Riaz S."/>
                <person name="Morales-Cruz A."/>
                <person name="Amrine K.C."/>
                <person name="McGuire B."/>
                <person name="Gubler W.D."/>
                <person name="Walker M.A."/>
                <person name="Cantu D."/>
            </authorList>
            <dbReference type="PubMed" id="25487071"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">c</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JNVN01000162">
        <property type="protein sequence ID" value="KHJ36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0B1PFF4"/>
    <dbReference type="STRING" id="52586.A0A0B1PFF4"/>
    <dbReference type="HOGENOM" id="CLU_059252_4_0_1"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030854">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017117">
        <property type="term" value="C:single-stranded DNA-dependent ATP-dependent DNA helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000018">
        <property type="term" value="P:regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            
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